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Items 1 to 64 of about 64
1. Miyai K, Yamamoto S, Asano T, Tamai S, Matsubara O, Tsuda H: Protein overexpression and gene amplification of epidermal growth factor receptor in adult testicular germ cell tumors: potential role in tumor progression. Cancer Sci; 2010 Sep;101(9):1970-6
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  • [Title] Protein overexpression and gene amplification of epidermal growth factor receptor in adult testicular germ cell tumors: potential role in tumor progression.
  • From the primary tumor sites of a cohort of 110 TGCT cases, we obtained 209 histologically distinct components: 53 intratubular germ cell neoplasia unclassified (IGCNU) lesions, 83 seminomas (66 pure-form seminomas and 17 seminoma components in the mixed-form with nonseminomatous TGCTs), 27 embryonal carcinomas, eight choriocarcinomas, 18 yolk sac tumors, and 20 immature teratomas.
  • Overexpression of the EGFR protein was detected in 28% of seminomas (27% in the pure-form and 29% in the mixed-form), 11% of embryonal carcinomas, 88% of choriocarcinomas, 44% of yolk sac tumors, and none of the IGCNU lesions or immature teratomas.
  • A higher copy number (≥4 copies per cell) and amplification of the EGFR gene were detected in 20% and 10% of seminomas, 13% and 0% of embryonal carcinomas, 71% and 60% of choriocarcinomas, 15% and 8% of yolk sac tumors, and none of the IGCNU lesions or immature teratomas, respectively.
  • [MeSH-minor] Adolescent. Adult. Aged. Chi-Square Distribution. Disease Progression. Gene Dosage. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Staging. Tissue Array Analysis. Tumor Burden. Young Adult

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  • [Copyright] © 2010 Japanese Cancer Association.
  • (PMID = 20608935.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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2. Khan A, Sultana K: Presenting signs and symptoms of ovarian cancer at a tertiary care hospital. J Pak Med Assoc; 2010 Apr;60(4):260-2
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  • On histology, papillary serous cystic adenocarcinoma was the most common (54%) type followed by mucinious (22%), endometroid (10.6%), yolk sac (2.6%), dysgerminoma (4%), and adult granulose cell tumour (5.3%).
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Early Detection of Cancer. Female. Humans. Middle Aged. Neoplasm Staging. Pakistan / epidemiology. Social Class

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  • (PMID = 20419965.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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3. Ghaemmaghami F, Hasanzadeh M, Karimi Zarchi M, Fallahi A: Nondysgerminomatous ovarian tumors: clinical characteristics, treatment, and outcome. A case-controlled study. Int J Surg; 2008 Oct;6(5):382-6
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  • Histological type of tumors included the following: immature teratoma (n=7), mixed germ-cell tumor (n=7), yolk sac tumors (n=4), and embryonal carcinoma (n=3).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / pathology. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Case-Control Studies. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness / pathology. Neoplasm Staging. Ovariectomy / methods. Retrospective Studies. Risk Assessment. Survival Analysis. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 18715834.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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4. Sada E, Shiratsuchi M, Kiyasu J, Idutsu K, Ohtsuka R, Nagasawa E, Karube K, Takayanagi R, Abe Y: Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome. J Clin Exp Hematop; 2009 Nov;49(2):117-20
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  • [Title] Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome.
  • A 20-year-old man with a primary non-seminomatous mediastinal germ cell tumor (yolk sac tumor and immature teratoma) developed hemophagocytic syndrome (HPS) three months after surgical resection.
  • Around the same time, the patient was found to have bone metastases of the germ cell tumor.
  • The thrombocytopenia was refractory to corticosteroid therapy but improved after chemotherapy performed for germ cell tumor progression.
  • Only three cases of germ cell tumor associated with reactive hemophagocytosis have been previously reported.
  • Successful treatment of the present case by chemotherapy for HPS suggests a close relationship between this rare complication and germ cell tumor.
  • [MeSH-major] Endodermal Sinus Tumor / therapy. Lymphohistiocytosis, Hemophagocytic / therapy. Mediastinal Neoplasms / therapy. Teratoma / therapy
  • [MeSH-minor] Adult. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Humans. Male. Neoplasm Metastasis. Remission Induction

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  • (PMID = 19907116.001).
  • [ISSN] 1880-9952
  • [Journal-full-title] Journal of clinical and experimental hematopathology : JCEH
  • [ISO-abbreviation] J Clin Exp Hematop
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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5. Soleymani Majd H, Turner SA, Choji K, Lwin K, B-Lynch C: Acute abdomen secondary to rare yolk sac tumour. Arch Gynecol Obstet; 2009 May;279(5):725-7
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  • [Title] Acute abdomen secondary to rare yolk sac tumour.
  • An emergency laparotomy was performed and she required a pelvic clearance for a Stage IIB ovarian tumour, later confirmed as a yolk sac tumour.
  • Accurate staging and tumour-reductive surgery strongly affects the prognosis of yolk sac tumours.
  • [MeSH-major] Abdomen, Acute / etiology. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Centralized Hospital Services. Clinical Competence. Female. Great Britain. Humans. Hysterectomy. Lymph Node Excision. Neoplasm Staging. Omentum / pathology. Omentum / surgery. Ovariectomy. Referral and Consultation. Rupture, Spontaneous / surgery. Tomography, X-Ray Computed

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  • (PMID = 18795306.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Kajo K, Macháleková K, Laca L: [Unusual clinical presentation of hepatic yolk sac tumour in periappendical region. A case report and review of the literature]. Cesk Patol; 2009 Oct;45(4):113-6
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  • [Title] [Unusual clinical presentation of hepatic yolk sac tumour in periappendical region. A case report and review of the literature].
  • [Transliterated title] Nezvycajná klinická prezentácia pecenového yolk sac tumoru v periapendikálnej oblasti. Kazuistika a prehl'ad literatúry.
  • Primary hepatic yolk sac tumour (YST) is a very rare neoplasm.
  • Consequently, there was discovered a tumor in the liver and the patient underwent right hemihepatectomy, hemicolectomy and ovariectomy, from which the YST was disclosed in the liver and in the coecum with spread into regional lymph nodes.
  • It has been suggested that these YSTs might originate from the germ cells that escaped during migration course from the yolk sac to the genital ridge during embryogenesis with subsequent malignant transformation or from persistent pluripotent embryonic cells in the liver, which escaped from the influence of differentiation during embryogenesis.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Appendix / pathology. Female. Humans. Young Adult

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  • (PMID = 20301839.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 39
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7. Chen CH, Chen TC, Huang WC, Chen TY, Liu HC: An unusual successfully treated case of pulmonary yolk sac tumor. Ann Thorac Surg; 2008 Feb;85(2):656-8
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  • [Title] An unusual successfully treated case of pulmonary yolk sac tumor.
  • Extragonadal germ cell tumors are relatively rare, particularly malignant yolk sac tumors arising in the lung parenchyma.
  • We report a case of a huge malignant yolk sac tumor in the right middle lobe.
  • The patient was successfully treated with neoadjuvant chemotherapy followed by complete resection of the tumor.
  • [MeSH-major] Endodermal Sinus Tumor / surgery. Lung Neoplasms / surgery. Neoadjuvant Therapy. Pneumonectomy / methods
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neoplasm Staging. Risk Assessment. Thoracotomy / methods. Treatment Outcome

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  • (PMID = 18222293.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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8. Watanabe IC, Billis A, Guimarães MS, Alvarenga M, de Matos AC, Cardinalli IA, Filippi RZ, de Castro MG, Suzigan S: Renal medullary carcinoma: report of seven cases from Brazil. Mod Pathol; 2007 Sep;20(9):914-20
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  • In spite of a relatively high incidence of sickle cell trait in Brazil, this is a rare tumor.
  • All cases disclosed the characteristic reticular pattern consisting of tumor cell aggregates forming spaces of varied size, reminiscent of yolk sac testicular tumors of reticular type.
  • [MeSH-minor] Abdominal Pain / etiology. Adolescent. Adult. Aged. Brazil. Carcinoembryonic Antigen / analysis. Child. Flank Pain / etiology. Hematuria / etiology. Humans. Immunohistochemistry. Keratins / analysis. Male. Mucin-1 / analysis. Neoplasm Metastasis. Risk Factors. Sickle Cell Trait / complications. Sickle Cell Trait / pathology. Time Factors. Treatment Outcome. Vimentin / analysis

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  • (PMID = 17643096.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins
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9. Umezu T, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Kikkawa F: Long-term outcome and prognostic factors for yolk sac tumor of the ovary. Nagoya J Med Sci; 2008 Mar;70(1-2):29-34
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  • [Title] Long-term outcome and prognostic factors for yolk sac tumor of the ovary.
  • Yolk sac tumors of the ovary (YST) are rare and highly malignant tumors occurring in children and young adults.
  • Those with an ascites volume of less than 100 ml or a residual tumor measuring less than 1 cm had improved to a relatively good prognosis.
  • In conclusion, the FIGO (International Federation of Gynecology and Obstetrics) stage, ascites volume and residual tumor size tended to affect the prognosis of YST.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Animals. Child. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Neoplasm Staging. Prognosis. Registries / statistics & numerical data. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 18807293.001).
  • [ISSN] 0027-7622
  • [Journal-full-title] Nagoya journal of medical science
  • [ISO-abbreviation] Nagoya J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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10. Cicin I, Saip P, Guney N, Eralp Y, Ayan I, Kebudi R, Topuz E: Yolk sac tumours of the ovary: evaluation of clinicopathological features and prognostic factors. Eur J Obstet Gynecol Reprod Biol; 2009 Oct;146(2):210-4
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  • [Title] Yolk sac tumours of the ovary: evaluation of clinicopathological features and prognostic factors.
  • OBJECTIVE: To evaluate the clinicopathological prognostic features, factors and outcomes of chemotherapy in ovarian yolk sac tumours (YST).
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Child. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Female. Follow-Up Studies. Humans. Hysterectomy. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Ovariectomy. Prognosis. Retrospective Studies. Risk Factors. Treatment Outcome. Young Adult

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  • (PMID = 19419810.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Ireland
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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11. Nogales FF, Buriticá C, Regauer S, González T: Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors. Am J Surg Pathol; 2005 Sep;29(9):1247-51
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  • [Title] Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors.
  • We present, for the first time, two yolk sac tumors (YST) in women 37 and 18 years of age, one with a typical parietovisceral pattern and the other with a glandular pattern, which were associated with extensive areas of mucinous carcinoid (MC).
  • The tumor in the first case had numerous nodules of tubulopapillary YST that merged with well-differentiated MC.
  • The tumor in the second case consisted of an AFP-positive glandular YST, with a glandulopapillary pattern closely resembling fetal lung type adenocarcinoma, coexisting with an AFP-negative, cytokeratin 20-positive, atypical MC; transitional areas between the two components were also seen.
  • We think that, in these cases, MC represented an unusual form of endodermal differentiation of the YST.
  • It is important to differentiate the yolk sac and carcinoid components due to their different responses to chemotherapy and to evaluate the possibility of mucinous carcinoid developing into a highly aggressive carcinoma.
  • [MeSH-major] Carcinoid Tumor / pathology. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Female. Humans. Immunohistochemistry. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis. Treatment Outcome. alpha-Fetoproteins / metabolism

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  • (PMID = 16096416.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / alpha-Fetoproteins
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12. Futagami M, Yokoyama Y, Shigeto T, Mizunuma H: A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall. Eur J Gynaecol Oncol; 2010;31(6):690-3
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  • [Title] A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall.
  • Few studies report on tissue morphology in recurrence of yolk sac tumor.
  • The case of the recurrence of a yolk sac tumor as a spindle cell sarcoma of the abdominal wall is presented.
  • A 27-year-old woman was referred to our hospital due to suspicion of an ovarian tumor.
  • Right salpingo-oophorectomy, partial omentectomy, and extirpation of disseminated foci as fertility-preserving surgery was done since the intraoperative pathological diagnosis was yolk sac tumor.
  • Final pathological examination showed a germ cell tumor of which yolk sac tumor formed the major component including a small area that appeared to be immature nerve tissue.
  • Although residual tumor was not less than 1 cm, clinical complete remission was reached after the sixth course of BEP regimen.
  • However, the recurrence of a yolk sac tumor as an unclassified spindle cell sarcoma of the abdominal wall was found about two years after the initial surgery.
  • The mesenchyme-like component of the yolk sac tumor is characterized by spindle cells originating from epithelial elements, and is likely to give rise to a chemoresistant, diversely differentiated sarcoma.
  • This report suggests that the sarcoma reported in the case here also arose when spindle cells of the mesenchyme-like component underwent sarcomatous change during or after chemotherapy, subsequently relapsed as a chemoresistant tumor, and metastasized.
  • [MeSH-major] Abdominal Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Neoplasm Recurrence, Local / pathology. Sarcoma / pathology
  • [MeSH-minor] Abdominal Wall / pathology. Adult. Fatal Outcome. Female. Humans. Neoplasm Staging

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  • (PMID = 21319519.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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13. Knezević V, Poljak M, Bradamante Z, Serman D, Levak-Svajger B, Svajger A: Yolk sac carcinoma derived from the rat epiblast as a renal isograft. Coll Antropol; 2005 Jun;29(1):189-97
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  • [Title] Yolk sac carcinoma derived from the rat epiblast as a renal isograft.
  • We report the novel observation that a biphasic, parieto-visceral (PYS/VYS) yolk sac carcinoma can develop from the isolated epiblast of the pre-primitive streak rat embryo in a prolonged cultivation in vivo as a renal isograft.
  • From the rest of the cylinder the 4 cell layers were isolated and transplanted separately under the kidney capsule of isogenic adult males.
  • After 4 weeks the hypoblast was resorbed, the extraembryonic ectoderm gave rise to hemorrhagic cysts and trophoblastic giant cells, the extraembryonic (visceral yolk sac) endoderm formed benign cystic PYS/VYS tumors, and the epiblast developed into a benign teratoma.
  • After prolonged (7-30 weeks) development of these teratomas as isografts, a malignant yolk sac carcinoma (YSC) developed in 45% of them.
  • It destroyed the teratoma and the recipient's kidney, metastasized to peritoneum and other sites, and caused abundant ascites containing clustered tumor cells.
  • The primary tumor was retransplantable subcutaneously as well as intraperitoneally, and displayed the characteristics of the mixed or biphasic PVYS carcinoma, with a progressive loss of the VYS component with time.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / veterinary. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / veterinary. Kidney Neoplasms / pathology. Kidney Neoplasms / veterinary. Teratoma / pathology. Teratoma / veterinary
  • [MeSH-minor] Animals. Ascites. Ectoderm. Embryo, Mammalian. Female. Kidney / pathology. Male. Neoplasm Metastasis. Neoplasms, Experimental. Rats. Transplants

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  • (PMID = 16117321.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Croatia
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14. Razzi S, Luisi S, Gabbanini M, Lazzeri L, Mazzini M, Petraglia F: Yolk sac tumor in a young girl: a case report. Gynecol Endocrinol; 2005 Jun;20(6):334-5
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  • [Title] Yolk sac tumor in a young girl: a case report.
  • BACKGROUND: Yolk sac tumor is a rare neoplasm characterized by high malignancy given its premature metastasis, that is frequent in adolescence.
  • Following salpingo-oophorectomy, it was revealed as a yolk sac tumor by histological diagnosis.
  • CONCLUSION: This is an interesting case of yolk sac tumor in a young girl, at an age typical for germ cell tumor.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents. Combined Modality Therapy. Diagnosis, Differential. Fallopian Tubes / surgery. Female. Humans. Ovariectomy

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  • (PMID = 16019383.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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15. Hong DG, Chong GO, Seong WJ, Lee YS, Cho YL, Park JY, Chae JM, Park IS: A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman. Eur J Gynaecol Oncol; 2010;31(4):471-4
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  • [Title] A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman.
  • Ovarian yolk sac tumor (YST) is a malignant ovarian neoplasm differentiated from primordial germ cells that occur in young age, while endometrioid carcinoma (ECA) is a müllerian epithelial tumor that usually occurs in older patients.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry

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  • (PMID = 20882900.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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16. Kan P, Gottfried ON, Blumenthal DT, Liu JK, Salzman KL, Townsend J, Jensen RL: Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature. J Neurooncol; 2006 Jul;78(3):249-53
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  • [Title] Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature.
  • METHODS: We present the unique case of a 25-year-old woman with an intradural, extramedullary primary yolk sac tumor (YST) at and below the level of the conus medullaris.
  • Despite an initial reduction in tumor size and clinical improvement in her neurologic exam, she re-presented a year after surgery with gross enlargement of her spinal tumor and CSF dissemination with metastasis to her brain.
  • When feasible (no evidence of CSF dissemination, metastasis, or multifocal disease), optimal treatment includes as extensive resection of tumor as possible followed by adjuvant chemotherapy and radiation.
  • [MeSH-major] Brain Neoplasms / secondary. Endodermal Sinus Tumor / secondary. Neoplasm Recurrence, Local / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans

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  • (PMID = 16773223.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 16
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17. Tong X, You Q, Li L, Cai L, Wang C, Zheng J: Prognostic factors of patients with ovarian yolk sac tumors: a study in Chinese patients. Onkologie; 2008 Dec;31(12):679-84
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  • [Title] Prognostic factors of patients with ovarian yolk sac tumors: a study in Chinese patients.
  • BACKGROUND: The aim of this study was to investigate the prognostic factors of ovarian yolk sac tumors (YST) and the survival rates in Chinese patients.
  • Age, histologic type, preoperative serum alpha-fetoprotein level, fertility-sparing surgery, tumor size and lymphadenectomy did not affect the prognosis of YST in our study.
  • Multivariate analysis confirmed cisplatin-based chemotherapy (hazard ratio (HR) = 4.945), chemotherapy courses > 3 (HR = 2.954), residual tumor < or = 2 cm (HR = 0.224) and ascites volume < or = 100 ml (HR = 0.389) as independent predictors for overall survival.
  • Cisplatin-based chemotherapy, chemotherapy courses, residual tumor size and ascites volume were independent prognosis factors.
  • [MeSH-major] Endodermal Sinus Tumor / mortality. Endodermal Sinus Tumor / therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / prevention & control. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / mortality
  • [MeSH-minor] Adult. China / epidemiology. Female. Humans. Middle Aged. Prevalence. Prognosis. Proportional Hazards Models. Risk Assessment / methods. Risk Factors. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19060506.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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18. Ulbright TM, Young RH: Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor. Am J Surg Pathol; 2005 Apr;29(4):500-5
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  • [Title] Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor.
  • The spaces often suggested reticular or microcystic patterns of yolk sac tumor, and the solid and hollow tubular patterns often added to the diagnostic confusion.
  • The hollow tubules appeared to result from central discohesion within nests of tumor.
  • The spaces, particularly when large, often contained occasional tumor cells or inflammatory cells within pale edema fluid.
  • The cytologic appearance of the cells lining the spaces, and in the surrounding tumor, retained the typical features of seminoma cells.
  • Distinction from yolk sac tumor is aided by the observation that the spaces of yolk sac tumor are often more irregular in their individual shapes and frequently form anastomosing channels.
  • Additionally, the spaces of yolk sac tumor randomly merge with various other yolk sac tumor patterns.
  • The cells lining spaces in yolk sac tumor are often flattened with compressed nuclei and lack the typical prominent nucleoli of seminoma cells.
  • Paucity of lymphocytes and intracystic edema, however, are not differentially helpful, although basophilic fluid favors yolk sac tumor.
  • A panel of immunostains (AE1/AE3, OCT-3/4, and alpha-fetoprotein) is helpful in the differential with yolk sac tumor in especially problematic cases.
  • The edema and paucity of lymphocytes may suggest spermatocytic seminoma, but the varied cell types of that neoplasm are absent.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Seminoma / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15767805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Petrakakou E, Grapsa D, Stergiou ME, Mikou P, Tsarpalis D, Polyzos A, Giahnaki A, Ioakim-Liossi A: Ascitic fluid cytology of yolk sac tumor of the ovary: a case report. Acta Cytol; 2009 Nov-Dec;53(6):701-3
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  • [Title] Ascitic fluid cytology of yolk sac tumor of the ovary: a case report.
  • BACKGROUND: Yolk sac tumor (YST) of the ovary is a rare neoplasm typically affecting children and young women.
  • We describe the cytomorphology of this tumor in ascitic fluid and discuss its differential diagnosis from other neoplasms.
  • [MeSH-major] Ascitic Fluid / pathology. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Aggregation. Female. Humans. Periodic Acid-Schiff Reaction. alpha-Fetoproteins / metabolism

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  • (PMID = 20014563.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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20. Ceyhan K, Utkan G, Dincol D, Erdogan N, Erekul S, Umudum H: Fine needle aspiration biopsy features with histologic correlation in mediastinal hepatoid yolk sac tumor presenting with sternum metastasis: a case report. Acta Cytol; 2007 Jul-Aug;51(4):610-5
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  • [Title] Fine needle aspiration biopsy features with histologic correlation in mediastinal hepatoid yolk sac tumor presenting with sternum metastasis: a case report.
  • BACKGROUND: The hepatoid variant of yolk sac tumor (H-YST) is an exceedingly rare and highly malignant neoplasm.
  • No tumor was found in the other organ systems.
  • Cytologically, the tumor was composed of monotonous, large, round to polygonal hepatoid cells forming solid sheets and trabeculae entrapped with endothelial cells resembling hepatocellular carcinoma.
  • Histopathologic sections of tumor showed tumor cells with eosinophilic to clear cytoplasm arranged in a solid, trabecular growth pattern, with some acinar formations.
  • CONCLUSION: Fine needle aspiration cytology, together with the characteristic clinical presentations and specific tumor markers, is crucial to the initial diagnosis of H-YST.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Mediastinal Neoplasms / pathology. Sternum / pathology
  • [MeSH-minor] Adult. Antibodies. Biopsy, Fine-Needle. Endothelial Cells / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Metastasis. alpha-Fetoproteins / metabolism

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  • (PMID = 17718136.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / alpha-Fetoproteins
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21. Tinica G, Butcovan D, Cimpeanu C, Târcoveanu E: A mediastinal germ cell tumor of yolk sac type--case report. Chirurgia (Bucur); 2010 Nov-Dec;105(6):831-4
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  • [Title] A mediastinal germ cell tumor of yolk sac type--case report.
  • OBJECTIVE: We report an extremely rare case of germ-cell tumor localized at the level of the anterior mediastinum.
  • Surgical intervention revealed an infiltrative mediastinal tumor involving the left subclavial vein, which was biopsied for morphological examination.
  • Immunohistochemical stains for alpha-fetoprotein were positive in the tumor cells while stains for carcinoembryonic antigen and placental like alkaline phosphatase were negative.
  • This supported the diagnosis of Yolk sac tumor, a rare primary tumor within the mediastinum.
  • CONCLUSION: Primary mediastinal Yolk sac neoplasm is a rare tumor.
  • In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor.
  • The single most important prognostic indicator is whether the tumor mass can be completely excised before or after chemotherapy.
  • [MeSH-major] Endodermal Sinus Tumor. Mediastinal Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Biopsy. Bleomycin / administration & dosage. Carcinoma / diagnosis. Cisplatin / administration & dosage. Diagnosis, Differential. Etoposide / administration & dosage. Humans. Male. Prognosis. alpha-Fetoproteins / metabolism

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  • (PMID = 21351701.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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22. Ui T, Horie H, Sato H, Miyakura Y, Sakuma Y, Hyodo M, Togashi K, Yasuda Y, Nagai H, Matsubara D: [Sigmoid colon cancer in a woman developing 22 years after radiation therapy for a yolk sac tumor]. Nihon Shokakibyo Gakkai Zasshi; 2009 May;106(5):668-73
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  • [Title] [Sigmoid colon cancer in a woman developing 22 years after radiation therapy for a yolk sac tumor].
  • She had undergone surgical resection following chemotherapy for yolk sac tumor at the age of 12 years, and had received additional surgery and radiation therapy for a local recurrence at age 13.
  • Following evaluation, a sigmoid colon tumor was detected and was surgically resected.
  • [MeSH-major] Adenocarcinoma / etiology. Endodermal Sinus Tumor / radiotherapy. Ovarian Neoplasms / radiotherapy. Radiotherapy / adverse effects. Sigmoid Neoplasms / etiology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Chronic Disease. Colitis / etiology. Female. Humans. Neoplasm Recurrence, Local. Ovariectomy. Time Factors

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  • (PMID = 19420871.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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23. de La Motte Rouge T, Pautier P, Duvillard P, Rey A, Morice P, Haie-Meder C, Kerbrat P, Culine S, Troalen F, Lhommé C: Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. Ann Oncol; 2008 Aug;19(8):1435-41
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  • [Title] Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor.
  • BACKGROUND: Ovarian yolk sac tumor (YST) is a very rare malignancy arising in young women.
  • However, given the rarity of this tumor, ovarian YST-specific survival and outcome after such treatment are not precisely known.

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  • (PMID = 18408223.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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24. Franco R, Esposito F, Fedele M, Liguori G, Pierantoni GM, Botti G, Tramontano D, Fusco A, Chieffi P: Detection of high-mobility group proteins A1 and A2 represents a valid diagnostic marker in post-pubertal testicular germ cell tumours. J Pathol; 2008 Jan;214(1):58-64
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  • They are abundantly expressed during embryogenesis and in most malignant neoplasias, whereas their expression is low or absent in normal adult tissues.
  • In this study we have evaluated, by immunohistochemistry, the expression of HMGA1 and HMGA2 in a series of post-pubertal testicular tumours of different histological types, including 30 seminomas, 15 teratomas, 15 embryonal carcinomas and 10 mixed germinal tumours with a prominent yolk sac tumour component.
  • HMGA1 protein expression was detected in all seminomas and embryonal carcinomas analysed, but not in teratomas or yolk sac carcinomas.
  • Conversely, HMGA2 was present only in embryonal carcinomas and yolk sac carcinomas, but not in seminomas or teratomas.
  • These findings indicate that HMGA1 and HMGA2 are differently expressed with respect to the state of differentiation of testicular germ cell tumours (TGCTs), with over-expression of both proteins in pluripotential embryonal carcinoma cells and loss of expression of HMGA1 in yolk sac tumours and of both proteins in the mature adult tissue of teratoma areas.
  • [MeSH-major] Biomarkers, Tumor / metabolism. HMGA1a Protein / metabolism. HMGA2 Protein / metabolism. Neoplasms, Germ Cell and Embryonal / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Blotting, Western. Gene Expression. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 17935122.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 124544-67-8 / HMGA1a Protein
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25. Amin RM, Kokubo T, Hiroshima K, Narita M, Itou K, Kuroki M, Tanizawa T, Nakatani Y: Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma. Pathol Int; 2005 Oct;55(10):649-54
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  • [Title] Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma.
  • Two years after testicular resection was carried out in a 40-year-old man that revealed mixed germ cell tumor of more than one histological type (seminoma, embryonal cell carcinoma, and yolk sac tumor), he presented with an asymptomatic pulmonary nodule in his left lower lobe.
  • Video-assisted thoracoscopic partial resection of the tumor revealed a 24 x 20 mm teratoma with somatic-type malignancy in which pleomorphic rhabdomyosarcoma was a major element.
  • One year later, asymptomatic tumor recurrence occurred at both edges of the stapler line as 22 x 20 mm and 10 x 5 mm nodules composed only of pleomorphic rhabdomyosarcoma.
  • Throughout the course there was no abdominal lymph node swelling detected by computed tomography (CT) and tumor markers were normal.
  • Adjuvant chemotherapy was started after the tumor recurrence.
  • Currently, the patient is still undergoing chemotherapy 5 months after the tumor recurrence.
  • In conclusion, despite the fact that primary pulmonary rhabdromyosarcoma is a rare neoplasm, metastatic pulmonary germ cell tumor with somatic-type malignancy showing predominantly rhabdomyosarcomatous differentiation should be considered in the differential diagnosis of such lesions of the lung.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 16185296.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. Subramanian VS, Gilligan T, Klein EA: A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. Nat Clin Pract Urol; 2008 Apr;5(4):220-3
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  • A scrotal ultrasound scan showed a right testicular mass, suspicious for neoplasm.
  • The patient underwent right inguinal orchiectomy and was diagnosed with nonseminomatous germ cell tumor of the right testis, composed of yolk sac tumor, teratoma, and embryonal carcinoma with no evidence of metastatic disease.
  • The patient has since remained disease-free, with normal levels of serum tumor markers and no evidence of metastasis on chest X-ray and abdominal CT.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chorionic Gonadotropin / blood. Disease Management. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local / therapy. Orchiectomy. alpha-Fetoproteins / analysis

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  • (PMID = 18268549.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / alpha-Fetoproteins
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27. Hartke DM, Agarwal PK, Palmer JS: Prepubertal male and testicular neoplasms: diagnosis and treatment. Drugs Today (Barc); 2006 Feb;42(2):127-33
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  • Prepubescent testicular tumors are far more likely to be benign than adult tumors.
  • However, malignant yolk sac tumors are still the most commonly reported testicular neoplasms in the literature.
  • Regardless of tumor type, with prompt diagnosis and treatment long-term survival is excellent.
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Neoplasm Staging. Orchiectomy. Puberty. Ultrasonography, Doppler, Duplex

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  • (PMID = 16541189.001).
  • [ISSN] 1699-3993
  • [Journal-full-title] Drugs of today (Barcelona, Spain : 1998)
  • [ISO-abbreviation] Drugs Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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28. Dimov ND, Zynger DL, Luan C, Kozlowski JM, Yang XJ: Topoisomerase II alpha expression in testicular germ cell tumors. Urology; 2007 May;69(5):955-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Primary GCT specimens from 109 patients, including 57 seminomas and 52 mixed GCTs (41 embryonal carcinomas, 23 yolk sac tumors, 19 seminomas, 8 choriocarcinomas, 17 teratomas with immature elements, and 16 teratomas with mature elements), were obtained from our archives.
  • The metastatic lesions from 11 of the patients with mixed GCTs included seven teratomas with mature components, five embryonal carcinomas, one yolk sac tumor, one choriocarcinoma, and one teratoma with immature components.
  • RESULTS: Most embryonal carcinoma (100%), yolk sac tumor (95%), seminoma (88%), and choriocarcinoma (62%) components of the GCTs were TopoIIalpha immunoreactive.
  • CONCLUSIONS: The results of our study have shown that TopoIIalpha is expressed in most seminomas, embryonal carcinomas, yolk sac tumors, and choriocarcinomas, suggesting a possible mechanism of sensitivity of these components to TopoIIalpha inhibitors.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / analysis. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / antagonists & inhibitors. DNA-Binding Proteins / metabolism. Neoplasms, Germ Cell and Embryonal / enzymology. Testicular Neoplasms / enzymology. Topoisomerase II Inhibitors
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / enzymology. Carcinoma, Embryonal / pathology. Choriocarcinoma / drug therapy. Choriocarcinoma / enzymology. Choriocarcinoma / pathology. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / enzymology. Endodermal Sinus Tumor / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Sampling Studies. Seminoma / drug therapy. Seminoma / enzymology. Seminoma / pathology. Sensitivity and Specificity. Teratoma / drug therapy. Teratoma / enzymology. Teratoma / pathology. Treatment Outcome

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  • (PMID = 17482942.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Topoisomerase II Inhibitors; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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29. Zynger DL, Dimov ND, Luan C, Teh BT, Yang XJ: Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol; 2006 Dec;30(12):1570-5
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  • Recently, GPC3 was reported to be one of the over-expressed genes in testicular yolk sac tumors by gene expression microarray analysis.
  • Tumors from 71 patients were examined, including components of 42 seminomas, 37 embryonal carcinomas, 24 yolk sac tumors, 20 teratomas with mature elements, 16 teratomas with immature elements, and 7 choriocarcinomas.
  • All yolk sac tumor (24/24) and choriocarcinoma (7/7) components were immunoreactive for GPC3, whereas only 38% of teratomas with immature elements and 8% of embryonal carcinomas expressed GPC3.
  • Our findings suggest a possible role of GPC3 in tumor cell differentiation.
  • Furthermore, GPC immunostaining may be useful in the pathologic diagnosis of nonseminomatous germ cell tumors, particularly yolk sac tumor, and choriocarcinoma.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Fluorescent Antibody Technique, Indirect. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17122513.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPC3 protein, human; 0 / Glypicans
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30. Shim KW, Kim DS, Choi JU: Mixed or metachronous germ-cell tumor? Childs Nerv Syst; 2007 Jun;23(6):713-8
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  • [Title] Mixed or metachronous germ-cell tumor?
  • OBJECTIVE AND IMPORTANCE: We report the extremely rare occurrence of a second germ-cell tumor at a different site and with different histological types long after total resolution of a pineal germinoma.
  • Neuroradiological studies revealed a tumor in the pineal region.
  • The tumor was biopsied with endoscope, and third ventriculostomy was performed.
  • Histologically, the tumor proved to be a germinoma.
  • The tumor was totally resolute.
  • Neuroradiological studies showed a tumor in the right temporal lobe.
  • INTERVENTION: The second tumor was totally removed.
  • Histologically, the tumor proved to be a mixed germ-cell tumor, which consisted a yolk-sac tumor and a germinoma.
  • After the second course of chemotherapy, magnetic resonance image studies revealed no evidence of the tumor.
  • CONCLUSION: The second tumor was considered to be a metachronous neoplasm rather than a recurrence of the original mixed germ-cell tumor, which consisted a yolk-sac tumor and a germinoma.
  • [MeSH-major] Brain Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Germinoma / pathology. Neoplasms, Multiple Primary / pathology. Pinealoma / pathology. Temporal Lobe / pathology
  • [MeSH-minor] Adult. Humans. Male. Ventriculostomy

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  • (PMID = 17187270.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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31. McKenney JK, Heerema-McKenney A, Rouse RV: Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol; 2007 Mar;14(2):69-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Their morphology varies widely and includes mature teratoma, immature teratoma, seminoma, yolk sac tumor, embryonal carcinoma, choriocarcinoma, and mixed GCTs.
  • This review attempts to dissect these issues by separating the discussion into 3 age groups: neonatal (congenital), children (prepubertal), and adult (postpubertal).
  • [MeSH-minor] Abdominal Neoplasms / pathology. Adult. Age Factors. Child. Child, Preschool. Diagnosis, Differential. Humans. Immunohistochemistry. Infant. Infant, Newborn. Neoplasm Staging. Neoplasms, Multiple Primary. Prognosis. Retroperitoneal Neoplasms / pathology. Sarcoma / pathology

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  • (PMID = 17471115.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 186
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32. Al Masri W, Alhendal A, Al Mishaan M: A ruptured retroperitoneal germ cell tumor with invasion into the duodenum: a case report. Gulf J Oncolog; 2007 Jul;(2):69-72
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  • [Title] A ruptured retroperitoneal germ cell tumor with invasion into the duodenum: a case report.
  • We report a rare case of a retroperitoneal germ cell tumor in a 31 years old male who presented with an acute abdomen.
  • The final pathology revealed a yolk sac tumor.
  • We present this rare case of a primary para-aortic extragonadal yolk sac tumor and the differential diagnosis of a retroperitoneal mass.
  • [MeSH-major] Duodenal Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Neoplasms, Second Primary / pathology. Retroperitoneal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Male. Neoplasm Invasiveness. Rupture, Spontaneous

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  • (PMID = 20084727.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
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33. Lin HC, Clark JY: Testicular teratoma presenting as a transilluminating scrotal mass. Urology; 2006 Jun;67(6):1290.e3-5
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  • Prepubertal testicular neoplasms are uncommon and differ from adult neoplasms in histopathologic features and presentation.
  • Although tumor registries cite yolk sac tumor as the most common prepubertal testis neoplasm, more recent studies have demonstrated benign tumors such as teratomas to be more common.

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  • (PMID = 16750249.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Ahmed HU, Arya M, Muneer A, Mushtaq I, Sebire NJ: Testicular and paratesticular tumours in the prepubertal population. Lancet Oncol; 2010 May;11(5):476-83
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  • Prepubertal testicular and paratesticular tumours are a rare group of tumours, distinct from postpubertal paediatric and adult tumours of this region.
  • Tumours within this group are testicular germ-cell tumours (such as benign teratoma, epidermoid cyst and malignant yolk-sac tumours) and stromal tumours (such as juvenile granulosa-cell, Leydig-cell, and Sertoli-cell tumours).
  • [MeSH-minor] Child. Combined Modality Therapy. Humans. Male. Neoplasm Staging. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / epidemiology. Neoplasms, Germ Cell and Embryonal / therapy. Sex Cord-Gonadal Stromal Tumors / diagnosis. Sex Cord-Gonadal Stromal Tumors / epidemiology. Sex Cord-Gonadal Stromal Tumors / therapy. Testicular Neoplasms / diagnosis. Testicular Neoplasms / epidemiology. Testicular Neoplasms / therapy

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
  • [CommentIn] Lancet Oncol. 2010 Sep;11(9):814 [20816371.001]
  • (PMID = 20434716.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0701302; United Kingdom / Medical Research Council / / G1002509
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 62
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35. De Jong J, Weeda S, Gillis AJ, Oosterhuis JW, Looijenga LH: Differential methylation of the OCT3/4 upstream region in primary human testicular germ cell tumors. Oncol Rep; 2007 Jul;18(1):127-32
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  • Expression regulation of OCT3/4 has been extensively studied in murine and human cell lines, including embryonic stem cell lines and tumor derived cell lines.
  • Normal testis parenchyma, peripheral blood lymphocytes, spermatocytic seminoma, yolk sac tumor and teratoma, and JKT-1 showed a consistent hypermethylation.
  • In contrast, seminoma and embryonal carcinoma were hypomethylated, confirmed by analyses after tumor micro-dissection.
  • In conclusion, the results obtained from this set of adult normal and neoplastic in vivo derived samples is in accordance to the in vitro data that expression of OCT3/4 is associated with specific changes in methylation.
  • [MeSH-major] DNA Methylation. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Neoplasms, Germ Cell and Embryonal / genetics. Octamer Transcription Factor-3 / genetics. Promoter Regions, Genetic / genetics. Testicular Neoplasms / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Carcinoma, Embryonal / genetics. Carcinoma, Embryonal / pathology. Cells, Cultured. Endodermal Sinus Tumor / genetics. Endodermal Sinus Tumor / pathology. Humans. Male. RNA, Messenger / genetics. RNA, Messenger / metabolism. Seminoma / genetics. Seminoma / pathology. Teratoma / genetics. Teratoma / pathology. Testis / metabolism. Testis / pathology

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  • (PMID = 17549357.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Octamer Transcription Factor-3; 0 / RNA, Messenger
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36. Wermann H, Stoop H, Gillis AJ, Honecker F, van Gurp RJ, Ammerpohl O, Richter J, Oosterhuis JW, Bokemeyer C, Looijenga LH: Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance. J Pathol; 2010 Aug;221(4):433-42
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  • We investigated the methylation pattern of normal fetal, infantile, and adult germ cells (n = 103) and GCTs (n = 251) by immunohistochemical staining for 5-(m)cytidine.
  • Undifferentiated GCTs (seminomas, intratubular germ cell neoplasia unclassified, and gonadoblastomas) are hypomethylated, whereas more differentiated GCTs (teratomas, yolk sac tumours, and choriocarcinomas) show a higher degree of methylation.
  • [MeSH-major] DNA Methylation. DNA, Neoplasm / genetics. Drug Resistance, Neoplasm / genetics. Germ Cells / metabolism. Neoplasms, Germ Cell and Embryonal / genetics
  • [MeSH-minor] Adult. Antimetabolites, Antineoplastic / pharmacology. Antineoplastic Agents / pharmacology. Azacitidine / pharmacology. Cell Differentiation / genetics. Cisplatin / pharmacology. DEAD-box RNA Helicases / metabolism. Female. Fetus / cytology. Gene Expression Regulation, Neoplastic / drug effects. Humans. Immunoenzyme Techniques. Infant. Male. Neoplasm Proteins / metabolism. Ovary / embryology. Reverse Transcriptase Polymerase Chain Reaction / methods. Seminoma / genetics. Seminoma / metabolism. Testicular Neoplasms / genetics. Testicular Neoplasms / metabolism. Testis / embryology

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  • (PMID = 20593487.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; EC 3.6.1.- / DDX4 protein, human; EC 3.6.4.13 / DEAD-box RNA Helicases; M801H13NRU / Azacitidine; Q20Q21Q62J / Cisplatin
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37. Mottet N, Berger N, Droz JP: [Diagnosis and staging of germ-cell tumours of the testis]. Rev Prat; 2007 Feb 28;57(4):365-78
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  • Non seminomatous tumours are heterogeneous, different sub-groups are described: embryonal carcinoma, teratoma, choriocarcinoma, yolk sac tumours, but components are often mixed.
  • [MeSH-major] Neoplasm Staging. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology. Testis / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Diagnosis, Differential. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Male. Orchiectomy. Practice Guidelines as Topic. Prognosis. Radiography, Abdominal. Radiography, Thoracic. Seminoma / diagnosis. Seminoma / pathology. Tomography, X-Ray Computed. Ultrasonography, Doppler, Color

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  • (PMID = 17455738.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Jha S, Chan KK, Poole CJ, Rollason TP: Pregnancy following recurrent angiosarcoma of the ovary--a case report and review of literature. Gynecol Oncol; 2005 Jun;97(3):935-7
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  • BACKGROUND: Ovarian angiosarcomas are rare tumors which may to be distinguished from other unusual primary ovarian tumors such as clear cell carcinoma, yolk sac tumor and leiomyosarcoma on the basis of histological appearance and immunohistochemistry.
  • She remains in remission 6 years after treatment of recurrence of the primary tumor and has had a successful pregnancy following treatment.
  • [MeSH-major] Hemangiosarcoma / therapy. Neoplasm Recurrence, Local. Ovarian Neoplasms / therapy. Pregnancy Complications, Neoplastic
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Fertility. Humans. Ifosfamide / administration & dosage. Pregnancy

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  • (PMID = 15943995.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 15
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39. Nakamura H, Takeshima H, Makino K, Kuratsu J: Evaluation of residual tissues after adjuvant therapy in germ cell tumors. Pediatr Neurosurg; 2007;43(2):82-91
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  • We evaluated the pathological findings of these heterogeneous tumors to determine the persistence of residual viable tumor cells after adjuvant therapy.
  • The pathological diagnosis in group 1 patients was mature teratoma, pineal cyst, and fibrous tissue with calcification; in group 2 it was yolk sac tumor (n = 1), immature teratoma (n = 3), mature teratoma (n = 4), and necrosis or fibrous tissue (n = 4).
  • While no group 1 patients manifested tumor cells, MIB-1-positive viable tumor cells were present in resected tissues from one-third of the group 2 patients (3 immature teratomas and 1 yolk sac tumor).
  • CONCLUSION: The absence of viable tumor cells in residual tissue indicates that the combination of cisplatin-based chemo- and radiotherapy was effective in our germinoma patients.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Neoplasm, Residual / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Protocols. Biopsy. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Giant Cells / pathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiotherapy, Adjuvant. Survival Rate. Trophoblasts / pathology

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17337917.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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40. Luo LM, Huang HF, Pan LY, Shen K, Wu M, Xu L: [Clinical analysis of 42 cases of primary malignant tumor in vagina]. Zhonghua Fu Chan Ke Za Zhi; 2008 Dec;43(12):923-7
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  • [Title] [Clinical analysis of 42 cases of primary malignant tumor in vagina].
  • OBJECTIVE: To analyze the clinical characters, treatment and prognosis of primary malignant tumor in vagina.
  • METHODS: A retrospective analysis of 42 patients diagnosed with primary malignant tumor in vagina in Peking Union Medical College Hospital (PUMCH) between Jan 1984 and Aug 2006 was performed.
  • RESULTS: Primary malignant tumor accounted for 0.98% (42/4286) in the total gynecological malignant tumors during that period in PUMCH.
  • Thirteen cases were squamous carcinoma, 13 cases were malignant melanoma, 8 cases were adenocarcinoma, 3 cases were yolk sac tumor and 5 cases were other types.
  • The 2-year survival rate of patients with squamous carcinoma was 46.8%, malignant melanoma 72.9%, adenocarcinoma 20.0% and patients with yolk sac tumor were all alive tumor-free after 6 - 10 years' follow up.
  • CONCLUSIONS: The prognosis of primary malignant tumor in vagina is affected by clinical stage and histological type.
  • Patients with yolk sac tumor can be cured only with chemotherapy.
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Infant. Melanoma / mortality. Melanoma / pathology. Melanoma / surgery. Melanoma / therapy. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Vagina / pathology. Vagina / surgery. Young Adult

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  • (PMID = 19134332.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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41. Sano M, Nakanishi Y, Yagasaki H, Honma T, Oinuma T, Obana Y, Suzuki A, Nemoto N: Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours. Histopathology; 2005 May;46(5):532-9
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  • By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma.
  • [MeSH-major] Germinoma / pathology. Neoplasm Proteins / genetics. Proto-Oncogene Proteins c-bcl-2 / genetics. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Myeloid Cell Leukemia Sequence 1 Protein. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15842635.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Myeloid Cell Leukemia Sequence 1 Protein; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Messenger
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42. Ushiku T, Shinozaki A, Shibahara J, Iwasaki Y, Tateishi Y, Funata N, Fukayama M: SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol; 2010 Apr;34(4):533-40
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  • The novel stem cell marker SALL4 has been identified as a diagnostic marker of germ cell tumors, especially yolk sac tumors, in gonadal organs.
  • To clarify the significance of SALL4 as an oncofetal protein, we investigated SALL4 expression by immunohistochemistry in non-neoplastic stomach and gastric carcinoma with particular emphasis on á-fetoprotein (AFP)-producing gastric carcinoma, as AFP-producing gastric carcinoma shares expression of AFP and glypican 3 (GPC3) with yolk sac tumors and hepatic neoplasms.
  • In addition, more detailed whole tissue section immunohistochemistry was performed on non-neoplastic gastric tissue from 5 adult and 8 fetal specimens, 6 hepatoblastomas, and 31 cases of AFP-producing gastric carcinomas.
  • [MeSH-minor] Aged. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / metabolism. Diagnosis, Differential. Female. Fetus / embryology. Fetus / metabolism. Gestational Age. Glypicans / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Stomach / embryology. Stomach / metabolism. Tissue Array Analysis. alpha-Fetoproteins / metabolism

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  • (PMID = 20182341.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glypicans; 0 / SALL4 protein, human; 0 / Transcription Factors; 0 / alpha-Fetoproteins
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43. Agnarsson BA, Gudbjartsson T, Einarsson GV, Magnusson K, Thoroddsen A, Bergthorsson JT, Amundadottir L, Barkardottir RB, Björnsson J: Testicular germ cell tumours in Iceland: a nationwide clinicopathological study. APMIS; 2006 Nov;114(11):779-83
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  • Non-seminomas were diagnosed in 45%, and these were further classified as mixed germ cell tumours (33%), embryonal carcinoma (8%), teratoma (3%), and yolk sac tumour (n=1).
  • [MeSH-minor] Adult. Child, Preschool. Humans. Iceland / epidemiology. Incidence. Male. Neoplasm Staging

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  • (PMID = 17078858.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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44. Agarwal PK, Palmer JS: Testicular and paratesticular neoplasms in prepubertal males. J Urol; 2006 Sep;176(3):875-81
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  • RESULTS: There is still a predominance of yolk sac tumors in prepubertal males, although some studies suggest that teratomas are more common but underreported due to their benign course in children.
  • Prepubertal males are diagnosed in a fashion similar to that in adult patients with an appropriate history and physical examination.
  • A palpable, nontender mass suggests the diagnosis and prompts scrotal ultrasound and tumor markers.
  • The addition of radiation, chemotherapy and/or retroperitoneal lymph node dissection depends on tumor stage and histological type.
  • CONCLUSIONS: Although it is rare in children, any solid scrotal mass in prepubertal males warrants evaluation for possible testicular or paratesticular neoplasm.

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  • (PMID = 16890643.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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45. Topuz S, Iyibozkurt AC, Akhan SE, Keskin N, Yavuz E, Salihoglu Y, Bengisu E, Berkman S: Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence. Eur J Gynaecol Oncol; 2008;29(6):635-7
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  • RESULTS: Twenty-three (56%) had dysgerminomas, eight (19.5%) had mixed germ cell tumors, three (7.3%) had yolk sac tumors, three (7.3%) had immature teratomas, two (4.8%) had squamous cell carcinoma arising from a mature teratoma, one (2.4%) had embryonal carcinoma and one choriocarcinoma.
  • Non-dysgerminoma histologic type, being operated on suboptimally and radically, and advanced tumor stage have been found to be risk factors for recurrence.
  • [MeSH-major] Dysgerminoma / surgery. Neoplasm Recurrence, Local. Neoplasms, Germ Cell and Embryonal / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cohort Studies. Female. Humans. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Factors. Young Adult

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  • (PMID = 19115694.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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46. Göbel U, Calaminus G, Schneider DT, Koch S, Teske C, Harms D: The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol. Klin Padiatr; 2006 Nov-Dec;218(6):309-14
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  • Patients were registered in the epidemiologic German Childrens Cancer Registry and the GPOH Childrens Tumor Registry for pathological review.
  • 1) EFS after complete tumor resection has been estimated to 0.96 +/- 0.01 in both observation periods.
  • 2) Incomplete tumor resection remains the main risk factor for relapse (EFS 0.55 +/- 0.09).
  • 4) In MAKEI 83/86/89 four newborns with teratoma died due to perioperative complications and nine children as a result of tumor progression, whereas in MAKEI 96 no newborn died, only one child died from tumor progression, and another child died during long time observation for another reason (meningitis).
  • 5) In accordance to the experience of the MAKEI 83/86/89 studies, no child of the MAKEI 96 study presented with yolk sac tumor at recurrence if adjuvant chemotherapy was administered during first-line treatment because of immaturity.
  • In contrast, more than half of the children with tumor recurrence after watch and wait strategy had yolk sac tumor in addition to teratoma.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Chi-Square Distribution. Child. Child, Preschool. Data Interpretation, Statistical. Disease Progression. Female. Humans. Infant. Infant, Newborn. Male. Neoplasm Recurrence, Local. Neoplasm Staging. Neoplasms, Germ Cell and Embryonal / pathology. Ovary / pathology. Prospective Studies. Randomized Controlled Trials as Topic. Sacrococcygeal Region. Sex Factors. Treatment Outcome. World Health Organization

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  • (PMID = 17080332.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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47. Malagón HD, Valdez AM, Moran CA, Suster S: Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol; 2007 Sep;31(9):1356-62
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  • The germ cell component consisted of pure mature or immature teratoma (23 cases), teratoma mixed with other seminomatous or nonseminomatous components (17), pure seminoma (2), intratubular germ cell neoplasia (1), and yolk sac tumor (1).
  • The SC included embryonal rhabdomyosarcoma (29), angiosarcoma (6), leiomyosarcoma (4), undifferentiated sarcoma (3), myxoid liposarcoma (1), malignant peripheral nerve sheath tumor (1), malignant "triton" tumor (1), and epithelioid hemangioendothelioma (1).
  • Thirty-two of 40 patients either died of tumor (25/40; 62.5%) or were alive with advanced, progressive disease (7/40; 17.5%), and only 8/40 (20%) were alive and free of disease between 5 to 40 months (mean=18 mo).
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Orchiectomy. Ovariectomy. Time Factors. Treatment Outcome

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  • (PMID = 17721191.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Radhika S, Bakshi A, Rajwanshi A, Nijhawan R, Das A, Kakkar N, Joshi K, Marwaha RK, Rao KL: Cytopathology of uncommon malignant renal neoplasms in the pediatric age group. Diagn Cytopathol; 2005 May;32(5):281-6
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  • These include the common Wilms' tumor/nephroblastoma and the uncommon neoplasms such as clear-cell sarcoma of the kidney (CCSK), rhabdoid tumor, renal-cell carcinoma, and others.
  • Aspirates from Wilms' tumor, which are mesenchyme predominant, show clusters of spindle cells associated with the matrix material.
  • Renal-cell carcinoma of childhood shows similar cytological features as its adult counterpart.
  • Rhabdoid tumor of the kidney is characterized by a monomorphic population of cells with abundant cytoplasm, eccentric nuclei with prominent nucleoli.
  • Intrarenal yolk sac tumor is a rare neoplasm and shows severely pleomorphic cells on aspiration.
  • Further, non-Wilms' renal malignant neoplasms must be distinguished from the common Wilms' tumor so that appropriate chemotherapy protocols may be instituted in cases where the tumor is in an advanced stage of malignancy.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Renal Cell / pathology. Endodermal Sinus Tumor / pathology. Kidney Neoplasms / pathology. Rhabdoid Tumor / pathology. Sarcoma, Clear Cell / pathology
  • [MeSH-minor] Adolescent. Cell Nucleus / pathology. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Staining and Labeling. Wilms Tumor / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15830360.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Abood G, Bowen M, Potkul R, Aranha G, Shoup M: Hepatic resection for recurrent metastatic ovarian cancer. Am J Surg; 2008 Mar;195(3):370-3; discussion 373
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  • Primary tumor type included serous cystadenocarcinoma (n = 8), granulosa cell (n = 1), and yolk sac (n = 1).
  • [MeSH-major] Hepatectomy. Liver Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cystadenocarcinoma / secondary. Cystadenocarcinoma / surgery. Endodermal Sinus Tumor / secondary. Endodermal Sinus Tumor / surgery. Female. Granulosa Cell Tumor / secondary. Granulosa Cell Tumor / surgery. Humans. Middle Aged. Retrospective Studies

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  • (PMID = 18207130.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] United States
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50. Matsuura Y, Kitajima M, Hachisuga T, Tanimoto A, Okura N, Kihara I: Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings. J Obstet Gynaecol Res; 2010 Aug;36(4):907-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings.
  • Malignant mixed müllerian tumor (MMMT) or carcinosarcoma of the female genital tract is a rare neoplasm.
  • Malignant ovarian tumor composed of müllerian epithelial tumor and malignant germ cell tumor is also rare, with most cases composed of endometrioid adenocarcinoma and yolk sac tumor.
  • The resected tumor measuring over 20 cm in diameter consisted of cystic and solid components and was very fragile.
  • Microscopic examination showed a heterogenous mixed tumor composed of malignant epithelial, malignant mesodermal and malignant neuroectodermal components.
  • There was no tumor immunoreactivity to alpha-fetoprotein, carcinoembryonic antigen, human chorionic gonadotropin, and inhibin.
  • This quite rare ovarian tumor closely resembled nasopharyngeal tumors described as 'teratoid carcinosarcoma' is biologically aggressive.
  • [MeSH-major] Carcinosarcoma / pathology. Mixed Tumor, Mullerian / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Ovary / pathology. Ovary / surgery

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  • (PMID = 20666968.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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51. Ikeda K, Tate G, Suzuki T, Mitsuya T: Cytomorphologic features of immature ovarian teratoma in peritoneal effusion: a case report. Diagn Cytopathol; 2005 Jul;33(1):39-42
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  • Immunohistochemical analysis revealed that immature gastrointestinal elements and yolk sac elements were positive for alpha-fetoprotein.
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Intermediate Filament Proteins / analysis. Keratin-20. Keratin-7. Keratins / analysis. Neoplasm Staging. alpha-Fetoproteins / analysis

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  • [Copyright] 2005 Wiley-Liss, Inc
  • (PMID = 15945092.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / alpha-Fetoproteins; 68238-35-7 / Keratins
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52. Salonen J, Leminen A, Stenman UH, Butzow R, Heikinheimo M, Heikinheimo O: Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. Tumour Biol; 2008;29(1):50-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Serum levels of alpha-fetoprotein, human chorionic gonadotropin and CA 125 were determined, and immunohistochemistry for CA 125 as well as the pluripotent stem cell markers AP-2gamma and Oct-3/4 was performed in tumor specimens and the NCC-IT human germinoma cell line.
  • Immunohistochemical evaluation revealed that in most cases the elevated CA 125 levels originated from the tumor tissue.
  • Most dysgerminomas as well as the germinoma cell line were positive for AP-2gamma and Oct-3/4, whereas the majority of yolk sac tumors and immature teratomas were negative.
  • [MeSH-major] Biomarkers, Tumor / metabolism. CA-125 Antigen / blood. Neoplasms, Germ Cell and Embryonal / metabolism. Octamer Transcription Factor-3 / metabolism. Ovarian Neoplasms / metabolism. Transcription Factor AP-2 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Chorionic Gonadotropin / blood. Female. Humans. Middle Aged. Neoplasm Staging. Prognosis. alpha-Fetoproteins / metabolism

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18497549.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / Chorionic Gonadotropin; 0 / Octamer Transcription Factor-3; 0 / Transcription Factor AP-2; 0 / alpha-Fetoproteins
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53. Iczkowski KA, Butler SL, Shanks JH, Hossain D, Schall A, Meiers I, Zhou M, Torkko KC, Kim SJ, MacLennan GT: Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. Hum Pathol; 2008 Feb;39(2):275-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 93 germ cell tumors (41 seminoma, 22 embryonal carcinoma, 18 teratoma, and 12 yolk sac tumor) were obtained from the central nervous system (30), mediastinum (23), retroperitoneum/abdomen (31), and other locations (9).
  • Epithelial membrane antigen discriminated teratoma from other nonseminomas with a sensitivity of 1 but reacted occasionally in embryonal carcinoma (3/15) and yolk sac tumor (2/7).
  • [MeSH-major] Biomarkers, Tumor / analysis. Germinoma / chemistry. Neoplasm Proteins / analysis. Ovarian Neoplasms / chemistry. Testicular Neoplasms / chemistry
  • [MeSH-minor] Adolescent. Adult. Antibodies, Monoclonal / analysis. Antibodies, Monoclonal, Murine-Derived. Female. Fluorescent Antibody Technique, Indirect. Humans. Male. Octamer Transcription Factor-3 / analysis. Sensitivity and Specificity. Transcription Factor AP-2 / analysis

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  • [ErratumIn] Hum Pathol. 2013 Dec;44(12):2873
  • (PMID = 18045648.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / Transcription Factor AP-2; 0 / monoclonal antibody D2-40
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54. Batistatou A, Scopa CD, Ravazoula P, Nakanishi Y, Peschos D, Agnantis NJ, Hirohashi S, Charalabopoulos KA: Involvement of dysadherin and E-cadherin in the development of testicular tumours. Br J Cancer; 2005 Dec 12;93(12):1382-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • In this study, we examined immunohistochemically the expression of E-cadherin and dysadherin in 120 testicular neoplasms (37 seminomas-26 classic, five spermatocytic and six anaplastic-, 45 embryonal carcinomas, 10 mixed germ cell tumours, two yolk sac tumours, 10 mature and eight immature teratomas and eight non-Hodgkin B-cell lymphomas), clinical stage I.
  • [MeSH-major] Cadherins / biosynthesis. Carcinoma, Embryonal / genetics. Carcinoma, Embryonal / physiopathology. Lymphoma, Non-Hodgkin / genetics. Lymphoma, Non-Hodgkin / physiopathology. Membrane Glycoproteins / biosynthesis. Neoplasm Proteins / biosynthesis. Testicular Neoplasms / genetics. Testicular Neoplasms / physiopathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Adhesion. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness

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55. Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP, Schneider DT, Nicholson JC, Coleman N: Malignant germ cell tumours of childhood: new associations of genomic imbalance. Br J Cancer; 2007 Feb 26;96(4):667-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Genomic imbalances have been described in these tumours but, largely because of the paucity of cases reported in the literature, it is unclear how they relate to abnormalities in adult MGCTs and impact on potential systems for classifying GCTs.
  • We have used metaphase-based comparative genomic hybridisation to analyse the largest series of paediatric MGCTs reported to date, representing 34 primary tumours (22 yolk sac tumours (YSTs), 11 germinomatous tumours and one metastatic embryonal carcinoma) occurring in children from birth to age 16, including 17 ovarian MGCTs.
  • Gain of 12p, which is invariably seen in adult MGCTs, was present in 53% of primary MGCTs of children aged 5-16 and was also observed in four of 14 YSTs affecting children less than 5.
  • Two of these cases (14% of MGCTs in children less than 5) showed gain of the 12p11 locus considered to be particularly relevant in adult MGCTs.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Follow-Up Studies. Humans. Infant. Infant, Newborn. Neoplasm Staging

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  • (PMID = 17285132.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2360055
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56. Cicin I, Eralp Y, Saip P, Ayan I, Kebudi R, Iyibozkurt C, Tuzlali S, Gorgun O, Topuz E: Malignant ovarian germ cell tumors: a single-institution experience. Am J Clin Oncol; 2009 Apr;32(2):191-6
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  • The histologic subtypes included 36 dysgerminomas, 11 yolk sac tumors, 3 immature teratomas, 1 embryonal carcinomas, and 19 mixed types.
  • Nondysgerminoma histology and residual tumor after surgery were unfavorable prognostic factors (P < 0.001 and P = 0.015).
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Humans. Medical Records. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19307952.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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57. Ataergin S, Ozet A, Arpaci F, Kilic S, Beyzadeoglu M, Komurcu S: Outcome of patients with stage II and III nonseminomatous germ cell tumors: results of a single center. Indian J Cancer; 2007 Jan-Mar;44(1):6-11

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  • MATERIALS AND METHODS: Biopsy specimens of 58 patients with stage II and III nonseminomatous germ cell tumors were analyzed by means of tumor histopathology, primary localization site of the tumor, relapse sites, initial serum tumor marker levels, the presence of persistent serum tumor marker elevation and the patients' outcome.
  • Analysis of the prognostic factors revealed that the localization site of the primary tumor (P<0.001), the initial beta-HCG level (p:0.0048), the presence of yolk sac and choriocarcinoma components in tumor (p:0.003 and p:0.004), relapse sites of tumor (lung versus other than lung) (p:0.003), persistent elevation of serum tumor markers (P<0.001) were significant prognostic factors in univariate analysis.
  • However, in multivariate analysis, only the localization site of tumor (p:0.049) and the relapse site (p:0.003) were found statistically significant.
  • CONCLUSIONS: This retrospective study revealed that in advanced stage of nonseminomatous germ cell tumors, the outcome is essentially related with the localization site of the tumor and the relapse site.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Adult. Carcinoma, Embryonal / metabolism. Carcinoma, Embryonal / pathology. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Disease-Free Survival. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Retroperitoneal Neoplasms / metabolism. Retroperitoneal Neoplasms / pathology. Retrospective Studies. Survival Rate. Testicular Neoplasms / metabolism. Testicular Neoplasms / pathology. Treatment Outcome. alpha-Fetoproteins / metabolism

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  • (PMID = 17401218.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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58. Parenti GC, Zago S, Lusa M, Campioni P, Mannella P: Association between testicular microlithiasis and primary malignancy of the testis: our experience and review of the literature. Radiol Med; 2007 Jun;112(4):588-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: The aims of this study were to evaluate the association of testicular microlithiasis with testicular neoplasm, to assess the accuracy of ultrasonography (US) in comparison with histology in detecting microlithiasis, and to identify the prevalent cytohistological features that accompany testicular cancer.
  • Histological evaluation identified nine seminomas, two mixed germ-cell tumours, one embryonal carcinoma, one yolk-sac tumour and one benign Sertoli-cell tumour.
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Reproducibility of Results

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  • (PMID = 17563846.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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59. Balzer BL, Ulbright TM: Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol; 2006 Jul;30(7):858-65
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  • Metastases in 31 cases were: pure seminoma (17, 3 with residual testicular seminoma), mixed GCT with seminoma (4, 3 with residual testicular seminoma), mixed nonseminomatous GCT (4, 3 with residual testicular GCT), pure embryonal carcinoma (2), pure teratoma (2, 1 with residual testicular teratoma), and pure yolk sac tumor (2).
  • In 5 cases with clinically diagnosed metastases, there was no histologic documentation of the nature of the metastatic tumor.
  • [MeSH-major] Neoplasm Regression, Spontaneous / pathology. Neoplasms, Germ Cell and Embryonal / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Chorionic Gonadotropin / blood. Cicatrix / pathology. Humans. Male. Middle Aged

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  • (PMID = 16819328.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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60. Contreras AL, Punar M, Tamboli P, Tu SM, Pisters L, Moran C, Czerniak BA, Guo CC: Mediastinal germ cell tumors with an angiosarcomatous component: a report of 12 cases. Hum Pathol; 2010 Jun;41(6):832-7
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  • No patient had a documented testicular germ cell tumor.
  • Microscopically, all tumors were composed of germ cell tumor.
  • The most common germ cell tumor component was teratoma (n = 10); and other germ cell tumor components included seminoma (n = 3), yolk sac tumor (n = 3), embryonal carcinoma (n = 2), and choriocarcinoma (n = 1).
  • The angiosarcomatous component was present in primary mediastinal tumors (n = 6), metastasis (n = 3), or both primary mediastinal tumor and metastasis (n = 3).
  • The angiosarcomatous component accounted for an average of 30% (range, 5%-95%) of the primary mediastinal tumor.
  • Our findings suggest that the presence of an angiosarcomatous component in mediastinal germ cell tumor, even in a small amount, is associated with a poor clinical outcome.
  • [MeSH-minor] Adult. Carcinoma / mortality. Carcinoma / pathology. Humans. Leiomyosarcoma / mortality. Leiomyosarcoma / pathology. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local. Rhabdomyosarcoma / mortality. Rhabdomyosarcoma / pathology. Survival Rate. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20153508.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA091846
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS614200; NLM/ PMC4163004
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61. Divrik RT, Akdoğan B, Ozen H, Zorlu F: Outcomes of surveillance protocol of clinical stage I nonseminomatous germ cell tumors-is shift to risk adapted policy justified? J Urol; 2006 Oct;176(4 Pt 1):1424-29; discussion 1429-30
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  • Risk factors evaluated were presence of vascular invasion, proportion of embryonal carcinoma, age, tumor size, preoperatively increased serum alpha-fetoprotein and the absence of yolk sac component.
  • The first evidence of relapse was most commonly the increase in serum tumor markers alone (28.8%) or in combination with other modalities (66.7%, overall 95.5%).
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Orchiectomy. Program Evaluation. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 16952649.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Luther N, Stetler WR Jr, Dunkel IJ, Christos PJ, Wellons JC 3rd, Souweidane MM: Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy. J Neurosurg Pediatr; 2010 Jan;5(1):61-7
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  • OBJECT: Endoscopic biopsy with concomitant third ventriculostomy (ETV) is a well-established diagnostic and therapeutic maneuver in patients presenting with noncommunicating hydrocephalus resulting from a tumor of the pineal region or posterior third ventricle.
  • Fenestration of the floor of the third ventricle theoretically provides a conduit for the subarachnoid dissemination of an intraventricular tumor.
  • METHODS: The authors conducted a review of all patients for whom an ETV and simultaneous endoscopic biopsy procedure or tumor resection had been performed at their institutions between 1995 and 2008.
  • New leptomeningeal disease (1 yolk sac tumor and 1 pineoblastoma) occurred in 2 patients.
  • [MeSH-major] Biopsy / adverse effects. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / surgery. Endoscopy. Meningeal Neoplasms / secondary. Neoplasm Seeding. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Pinealoma / pathology. Pinealoma / surgery. Subarachnoid Space / pathology. Third Ventricle / pathology. Third Ventricle / surgery. Ventriculostomy / adverse effects
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20043737.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Young RH: Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol; 2005 Feb;18 Suppl 2:S81-98
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  • One variant of Sertoli cell tumor, the large cell calcifying form, appears to be restricted to the male gonad and in contrast to other sex cord tumors is much more frequently bilateral and is associated in many cases with unusual clinical manifestations.
  • In females, it is in the form of the sex cord with annular tubules whereas in males, the lesion has features that are often intermediate between those of a sex cord tumor with annular tubules and a large cell calcifying Sertoli cell tumor.
  • Granulosa cell tumors are much more common in females and in both gonads are divided into adult and juvenile forms.
  • The juvenile granulosa cell tumor of the testis tends to occur in the first 6 months of life and should be carefully distinguished from the yolk sac tumor of the testis, which usually occurs in a slightly older age group.
  • In females, this is a relatively common placement for a neoplasm in a pregnant patient.
  • Unclassified tumors are overall more common in males and may entrap residual normal germ cells potentially leading to the erroneous placement of the tumor in the category of a mixed germ cell sex cord-stromal tumor.
  • [MeSH-minor] Diagnosis, Differential. Female. Granulosa Cell Tumor / pathology. Humans. Male. Sertoli Cell Tumor / pathology

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  • (PMID = 15502809.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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64. Verma M, Al Hakim A, Berney D: Late recurrence of an ovarian yolk sac tumour as a carcinosarcoma. Pathology; 2007 Dec;39(6):601-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late recurrence of an ovarian yolk sac tumour as a carcinosarcoma.
  • [MeSH-major] Carcinosarcoma / pathology. Endodermal Sinus Tumor / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Fallopian Tubes / pathology. Fallopian Tubes / surgery. Fatal Outcome. Female. Humans

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  • (PMID = 18027268.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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