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1
adult t cell leukemia lymphoma clinical 2005:2010[pubdate] *count=100
1519 results
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Items 1 to 100 of about 1519
1.
Vonderheid EC, Pena J, Nowell P:
Sézary cell counts in erythrodermic cutaneous T-cell lymphoma: implications for prognosis and staging.
Leuk Lymphoma
; 2006 Sep;47(9):1841-56
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[Title]
Sézary
cell
counts in erythrodermic cutaneous T-
cell lymphoma
: implications for prognosis and staging.
In this retrospective study, quantitative Sézary
cell
counts were performed at presentation on 192 patients with erythrodermic cutaneous T-
cell lymphoma
(E-CTCL).
Per recommendation of the International Society of Cutaneous
Lymphomas
(ISCL), the impact on staging of using an absolute Sézary
cell
count of 1.0 K microL-1 or more as equivalent to lymph node involvement was investigated.
Of 132 patients with
disease
initially classified at stage III using the current TNM staging system, 25% were up staged to IVa, resulting in a clearer separation of
associated
survival curves between the stages.
Furthermore, the current ISCL definition of B0, B1 and B2 ratings were improved using Sézary
cell
count levels of < 1.0 K microL-1, > or = 1.0 - 4.99 K microL-1 and > or = 5.0 K microL-1, respectively.
The
clinical
importance of these variables vis-Ã -vis the modified TNBM staging system will need to be clarified in future studies.
[MeSH-major]
Dermatitis, Exfoliative /
diagnosis
.
Lymphoma
, T-
Cell
, Cutaneous /
diagnosis
. Sezary Syndrome / blood. Skin Neoplasms /
diagnosis
[MeSH-minor]
Adult
. Aged. Aged, 80 and over.
Cell
Count. Female. Humans. Lymph Nodes. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies
Genetic Alliance.
consumer health - Cutaneous T-Cell Lymphoma
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MedlinePlus Health Information.
consumer health - Skin Cancer
.
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(PMID = 17064997.001).
[ISSN]
1042-8194
[Journal-full-title]
Leukemia & lymphoma
[ISO-abbreviation]
Leuk. Lymphoma
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
2.
Kim YM, RamÃrez JA, Mick JE, Giebler HA, Yan JP, Nyborg JK:
Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation.
J Biol Chem
; 2007 Jun 29;282(26):18750-7
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[Title]
Molecular characterization of the Tax-containing
HTLV
-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation.
Transcriptional activation of
human
T-
cell leukemia
virus
type 1 (
HTLV
-1) is mediated by the viral oncoprotein Tax, which utilizes cellular transcriptional machinery to perform this function.
The coactivator CREB-binding protein (CBP)/p300 binds to this promoter-bound ternary complex, which promotes the initiation of
HTLV
-1 transcription.
Consonant with a fundamental role for CREB phosphorylation in Tax recruitment to the complex, we found that CREB is highly phosphorylated in a panel of
HTLV
-1-infected
human
T-
cell
lines.
Because pCREB has been implicated in leukemogenesis, enhancement of CREB phosphorylation by the
virus
may play a role in the etiology of
adult T
-
cell leukemia
.
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(PMID = 17449469.001).
[ISSN]
0021-9258
[Journal-full-title]
The Journal of biological chemistry
[ISO-abbreviation]
J. Biol. Chem.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA055035; United States / NCI NIH HHS / CA / CA55035; United States / NCI NIH HHS / CA / CA055035-14S1; United States / NCI NIH HHS / CA / CA055035-14; United States / NCI NIH HHS / CA / R01 CA055035-14S1; United States / NCI NIH HHS / CA / CA55035-S1; United States / NCI NIH HHS / CA / R01 CA055035-14
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / CREB1 protein, human; 0 / Cyclic AMP Response Element-Binding Protein
3.
Pais-Correia AM, Sachse M, Guadagnini S, Robbiati V, Lasserre R, Gessain A, Gout O, Alcover A, Thoulouze MI:
Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.
Nat Med
; 2010 Jan;16(1):83-9
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[Title]
Biofilm-like extracellular viral assemblies mediate
HTLV
-1
cell
-to-
cell
transmission at virological synapses.
Human
T cell leukemia
virus
type 1 (
HTLV
-1) is
a lymphotropic
retrovirus whose
cell
-to-
cell
transmission requires
cell
contacts.
HTLV
-1-infected T lymphocytes form 'virological synapses', but the mechanism of
HTLV
-1 transmission remains poorly understood.
We show here that
HTLV
-1-infected T lymphocytes transiently store viral particles as carbohydrate-rich extracellular assemblies that are held together and attached to the
cell
surface by virally-induced extracellular matrix components, including collagen and agrin, and cellular linker proteins, such as tetherin and galectin-3.
Extracellular viral assemblies rapidly adhere to other cells upon
cell
contact, allowing
virus
spread and infection of target cells.
Their removal strongly reduces the ability of
HTLV
-1-producing cells to infect target cells.
Our findings unveil a novel
virus
transmission mechanism based on the generation of extracellular viral particle assemblies whose structure, composition and function resemble those of bacterial biofilms.
HTLV
-1 biofilm-like structures represent a major route for
virus
transmission from
cell
to
cell
.
[MeSH-major]
CD4-
Positive
T-Lymphocytes / virology. Extracellular Matrix / virology.
HTLV
-I Infections / transmission.
Human
T-
lymphotropic virus
1 / physiology
[MeSH-minor]
Biofilms. Concanavalin A. Gene Products, env / metabolism. Humans. Microscopy, Electron, Transmission.
Virus
Assembly / physiology.
Virus
Attachment.
Virus
Internalization
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[CommentIn]
Nat Med. 2010 Jan;16(1):25-7
[
20057417.001
]
(PMID = 20023636.001).
[ISSN]
1546-170X
[Journal-full-title]
Nature medicine
[ISO-abbreviation]
Nat. Med.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Gene Products, env; 11028-71-0 / Concanavalin A
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4.
Yu Q, Minoda Y, Yoshida R, Yoshida H, Iha H, Kobayashi T, Yoshimura A, Takaesu G:
HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein.
Biochem Biophys Res Commun
; 2008 Jan 4;365(1):189-94
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[Title]
HTLV
-1 Tax-mediated TAK1 activation involves TAB2 adapter protein.
Human
T cell leukemia
virus
type 1 (
HTLV
-1) Tax is an oncoprotein that plays a crucial role in the proliferation and transformation of
HTLV
-1-infected T lymphocytes.
[MeSH-major]
Adaptor Proteins, Signal Transducing / metabolism. Gene Products, tax / metabolism.
Human
T-
lymphotropic virus
1 / metabolism. MAP Kinase Kinase Kinases / metabolism
[MeSH-minor]
Binding Sites.
Cell
Line. Humans. NF-kappa B / metabolism. Ubiquitin-Protein Ligases / metabolism
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(PMID = 17986383.001).
[ISSN]
1090-2104
[Journal-full-title]
Biochemical and biophysical research communications
[ISO-abbreviation]
Biochem. Biophys. Res. Commun.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / Gene Products, tax; 0 / NF-kappa B; 0 / TAB2 protein, human; 0 / tax protein, Human T-lymphotrophic virus 1; EC 2.7.11.25 / MAP Kinase Kinase Kinases; EC 2.7.11.25 / MAP kinase kinase kinase 7; EC 6.3.2.19 / Ubiquitin-Protein Ligases
5.
Kuchinskaya E, Heyman M, Grandér D, Linderholm M, Söderhäll S, Zaritskey A, Nordgren A, Porwit-Macdonald A, Zueva E, Pawitan Y, Corcoran M, Nordenskjöld M, Blennow E:
Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles.
Eur J Haematol
; 2005 Jun;74(6):466-80
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[Title]
Children and adults with
acute
lymphoblastic
leukaemia
have similar gene expression profiles.
OBJECTIVES: To compare the gene expression pattern in children and adults with
acute
lymphoblastic
leukaemia
(ALL) in order to improve our understanding of the difference in
disease
biology and prognosis.
RESULTS: Unsupervised hierarchical cluster analysis revealed that, in spite of differences in outcome, patients clustered irrespective of age, first by T-
cell
or B-precursor immunophenotype, and second by cytogenetic changes within the B-precursor group.
CONCLUSIONS: In spite of the difference in
clinical
outcome, the gene expression pattern in children and adults with ALL is very similar and is primarily dependent on immunophenotype and cytogenetic aberrations.
[MeSH-major]
Gene Expression Regulation, Leukemic. Oligonucleotide Array Sequence Analysis. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ genetics
[MeSH-minor]
Adult
. Child. Child, Preschool. Female. Fusion Proteins, bcr-abl / biosynthesis. Fusion Proteins, bcr-abl / genetics. Gene Deletion. Gene Expression Profiling. Genes, p16. Humans. Male. Philadelphia Chromosome
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(PMID = 15876250.001).
[ISSN]
0902-4441
[Journal-full-title]
European journal of haematology
[ISO-abbreviation]
Eur. J. Haematol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Denmark
[Chemical-registry-number]
EC 2.7.10.2 / Fusion Proteins, bcr-abl
6.
Ohsugi T, Kumasaka T, Okada S, Ishida T, Yamaguchi K, Horie R, Watanabe T, Umezawa K:
Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines.
Cancer Lett
; 2007 Nov 18;257(2):206-15
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[Title]
Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient
adult T
-
cell leukemia
-
derived
cell
lines.
Adult T
-
cell leukemia
(
ATL
) is an aggressive neoplasm caused by
human
T-
cell leukemia
virus
type I (
HTLV
-I), which induces nuclear factor-kappaB (NF-kappaB), a molecule central to the ensuing neoplasia.
The NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) has been shown to inhibit NF-kappaB activation in Tax-expressing
HTLV
-I-infected cells.
In this study, we used NOD/SCID beta2-microglobulin(null) mice to show that intraperitoneal inoculation with Tax-deficient
ATL
cell
lines caused rapid death, whereas DHMEQ-treated mice survived.
Furthermore, DHMEQ treatment after subcutaneous inoculation inhibited the growth of transplanted
ATL
cells.
These results demonstrate that DHMEQ has therapeutic efficacy on
ATL
cells, regardless of Tax expression.
[MeSH-major]
Benzamides / pharmacology. Cyclohexanones / pharmacology. Gene Products, tax / deficiency.
Leukemia
, T-
Cell
/ prevention & control. Xenograft Model Antitumor Assays / methods
[MeSH-minor]
Adult
. Animals. Apoptosis / drug effects.
Cell
Line, Tumor.
Human
T-
lymphotropic virus
1 / genetics.
Human
T-
lymphotropic virus
1 / metabolism. Humans. Mice. Mice, Inbred NOD. Mice, Knockout. Mice, SCID. NF-kappa B / antagonists & inhibitors. NF-kappa B / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Survival Analysis. Tumor Burden. beta 2-Microglobulin / genetics. beta 2-Microglobulin / metabolism
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(PMID = 17764832.001).
[ISSN]
0304-3835
[Journal-full-title]
Cancer letters
[ISO-abbreviation]
Cancer Lett.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Benzamides; 0 / Cyclohexanones; 0 / Gene Products, tax; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / beta 2-Microglobulin; 0 / dehydroxymethylepoxyquinomicin
7.
Raetz EA, Perkins SL, Bhojwani D, Smock K, Philip M, Carroll WL, Min DJ:
Gene expression profiling reveals intrinsic differences between T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
Pediatr Blood Cancer
; 2006 Aug;47(2):130-40
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[Title]
Gene expression profiling reveals intrinsic differences between T-
cell
acute
lymphoblastic
leukemia
and T-
cell
lymphoblastic
lymphoma
.
BACKGROUND: T-
cell
acute
lymphoblastic
leukemia
(T-ALL) and T-
cell
lymphoblastic
lymphoma
(T-LL) and are often thought to represent a spectrum of a single
disease
.
The malignant cells in T-ALL and T-LL are morphologically indistinguishable, and they share the expression of common
cell
surface antigens and cytogenetic characteristics.
However, despite these similarities, differences in the
clinical
behavior of T-ALL and T-LL are observed.
CONCLUSIONS: Despite significant similarities between the malignant T-
cell
precursors, clear differences in the gene expression profiles were observed between T-ALL and T-LL implying underlying differences in the biology of the two entities.
[MeSH-major]
Gene Expression Profiling.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ genetics.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ pathology. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ genetics. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ pathology
Genetic Alliance.
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.
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consumer health - Lymphoblastic lymphoma
.
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(PMID = 16358311.001).
[ISSN]
1545-5009
[Journal-full-title]
Pediatric blood & cancer
[ISO-abbreviation]
Pediatr Blood Cancer
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / U01 CA88361
[Publication-type]
Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
8.
Toulza F, Nosaka K, Tanaka Y, Schioppa T, Balkwill F, Taylor GP, Bangham CR:
Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells.
J Immunol
; 2010 Jul 01;185(1):183-9
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[Title]
Human
T-
lymphotropic virus
type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells.
We recently reported that
human
T-
lymphotropic virus
type 1 (
HTLV
-1) infection is accompanied by a high frequency of CD4(+)FoxP3(+) cells in the circulation.
In asymptomatic carriers of
HTLV
-1 and in patients with
HTLV
-1-
associated
inflammatory and malignant diseases, a high FoxP3(+)
cell
frequency correlated with inefficient cytotoxic
T cell
-mediated killing of
HTLV
-1-infected cells.
In
adult T cell leukemia
/
lymphoma
(
ATLL
), the FoxP3(+) population was distinct from the leukemic
T cell
clones.
However, the cause of the increase in FoxP3(+)
cell
frequency in
HTLV
-1 infection was unknown.
In this study, we report that the plasma concentration of the chemokine CCL22 is abnormally high in
HTLV
-1-infected subjects and that the concentration is strongly correlated with the frequency of FoxP3(+) cells, which express the CCL22 receptor CCR4.
Further, we show that CCL22 is produced by cells that express the
HTLV
-1 transactivator protein Tax, and that the increased CCL22 enhances the migration and survival of FoxP3(+) cells in vitro.
Finally, we show that FoxP3(+) cells inhibit the proliferation of ex vivo, autologous leukemic clones from patients with
ATLL
.
We conclude that
HTLV
-1-induced CCL22 causes the high frequency of FoxP3(+) cells observed in
HTLV
-1 infection; these FoxP3(+) cells may both retard the progression of
ATLL
and
HTLV
-1-
associated
inflammatory diseases and contribute to the immune suppression seen in
HTLV
-1 infection, especially in
ATLL
.
[MeSH-major]
Cell
Proliferation. Chemokine CCL22 / physiology. Forkhead Transcription Factors / physiology.
Human
T-
lymphotropic virus
1 / immunology. T-Lymphocytes, Regulatory / cytology. T-Lymphocytes, Regulatory / immunology
[MeSH-minor]
CD4 Lymphocyte Count.
Cell
Survival / immunology. Cytotoxicity Tests, Immunologic.
HTLV
-I Infections / immunology.
HTLV
-I Infections / pathology. Humans. Jurkat Cells.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ immunology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ pathology. T-Lymphocytes, Cytotoxic / cytology. T-Lymphocytes, Cytotoxic / immunology. T-Lymphocytes, Cytotoxic / virology
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Blood. 2001 Aug 1;98(3):721-6
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]
(PMID = 20525891.001).
[ISSN]
1550-6606
[Journal-full-title]
Journal of immunology (Baltimore, Md. : 1950)
[ISO-abbreviation]
J. Immunol.
[Language]
eng
[Grant]
United Kingdom / Wellcome Trust / / 080871; United Kingdom / Medical Research Council / / G0501974; United Kingdom / Wellcome Trust / /
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / CCL22 protein, human; 0 / Chemokine CCL22; 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors
[Other-IDs]
NLM/ EMS51736; NLM/ PMC3575032
9.
Mori N:
[Molecular targeted therapy in adult T-cell leukemia/lymphoma].
Nihon Rinsho
; 2007 Jan 28;65 Suppl 1:709-18
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[Title]
[Molecular targeted therapy in
adult T
-
cell leukemia
/
lymphoma
].
[MeSH-major]
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ drug therapy
[MeSH-minor]
Adult
. Antigens, Surface / immunology. HSP90 Heat-Shock Proteins / antagonists & inhibitors. Humans. NF-kappa B / antagonists & inhibitors. Phosphatidylinositol 3-Kinases / antagonists & inhibitors. Protein-Tyrosine Kinases / antagonists & inhibitors
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(PMID = 17474481.001).
[ISSN]
0047-1852
[Journal-full-title]
Nihon rinsho. Japanese journal of clinical medicine
[ISO-abbreviation]
Nippon Rinsho
[Language]
jpn
[Publication-type]
Journal Article; Review
[Publication-country]
Japan
[Chemical-registry-number]
0 / Antigens, Surface; 0 / HSP90 Heat-Shock Proteins; 0 / NF-kappa B; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Protein-Tyrosine Kinases
[Number-of-references]
30
10.
Hoshi M, Ito H, Fujigaki H, Takemura M, Takahashi T, Tomita E, Ohyama M, Tanaka R, Saito K, Seishima M:
Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity.
Leuk Res
; 2009 Jan;33(1):39-45
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[Title]
Indoleamine 2,3-dioxygenase is highly expressed in
human
adult T
-
cell leukemia
/
lymphoma
and chemotherapy changes tryptophan catabolism in serum and reduced activity.
Adult T
-
cell leukemia
/
lymphoma
(
ATLL
) is caused by
human
T-
cell
lymphotropic virus
type 1 (
HTLV
-1).
In this study, we investigated the IDO expression in
ATLL
cells and the effect of chemotherapy on IDO-initiating l-TRP catabolism in patients with
ATLL
.
Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in
ATLL
cells were significantly increased in
ATLL
patients compared to those in healthy and
HTLV
-
positive
carrier subjects.
On the other hand, l-TRP level was significantly decreased in
ATLL
patients compared to that in healthy subjects.
In the immunohistochemical staining, IDO was strongly expressed in cytoplasm of
ATLL
cells.
These data provide evidence that IDO is highly expressed in
ATLL
cells, and that IDO-initiating l-TRP catabolism changes with chemotherapy.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ enzymology. Tryptophan / blood
[MeSH-minor]
Adult
. Aged. Base Sequence. DNA Primers. Female. Humans. Immunohistochemistry. Male. Middle Aged. Treatment Outcome
Hazardous Substances Data Bank.
(L)-Tryptophan
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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Cited by Patents in
.
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(PMID = 18639341.001).
[ISSN]
0145-2126
[Journal-full-title]
Leukemia research
[ISO-abbreviation]
Leuk. Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / DNA Primers; 0 / Indoleamine-Pyrrole 2,3,-Dioxygenase; 8DUH1N11BX / Tryptophan
11.
Trageser D, Iacobucci I, Nahar R, Duy C, von Levetzow G, Klemm L, Park E, Schuh W, Gruber T, Herzog S, Kim YM, Hofmann WK, Li A, Storlazzi CT, Jäck HM, Groffen J, Martinelli G, Heisterkamp N, Jumaa H, Müschen M:
Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.
J Exp Med
; 2009 Aug 3;206(8):1739-53
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[Title]
Pre-B
cell
receptor-mediated
cell
cycle arrest in Philadelphia chromosome-
positive acute
lymphoblastic
leukemia
requires IKAROS function.
B
cell
lineage
acute
lymphoblastic
leukemia
(ALL) arises in virtually all cases from B
cell
precursors that are arrested at pre-B
cell
receptor-dependent stages.
The Philadelphia chromosome-
positive
(Ph(+)) subtype of ALL accounts for 25-30% of cases of
adult
ALL, has the most unfavorable
clinical
outcome among all ALL subtypes and is defined by the oncogenic BCR-ABL1 kinase and deletions of the IKAROS gene in >80% of cases.
Here, we demonstrate that the pre-B
cell
receptor functions as a tumor suppressor upstream of IKAROS through induction of
cell
cycle arrest in Ph(+) ALL cells.
Pre-B
cell
receptor-mediated
cell
cycle arrest in Ph(+) ALL cells critically depends on IKAROS function, and is reversed by coexpression of the dominant-negative IKAROS splice variant IK6.
IKAROS also promotes tumor suppression through cooperation with downstream molecules of the pre-B
cell
receptor signaling pathway, even if expression of the pre-B
cell
receptor itself is compromised.
In this case, IKAROS redirects oncogenic BCR-ABL1 tyrosine kinase signaling from SRC kinase-activation to SLP65, which functions as a critical tumor suppressor downstream of the pre-B
cell
receptor.
These findings provide a rationale for the surprisingly high frequency of IKAROS deletions in Ph(+) ALL and identify IKAROS-mediated
cell
cycle exit as the endpoint of an emerging pathway of pre-B
cell
receptor-mediated tumor suppression.
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Mouse Genome Informatics (MGI)
.
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NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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(PMID = 19620627.001).
[ISSN]
1540-9538
[Journal-full-title]
The Journal of experimental medicine
[ISO-abbreviation]
J. Exp. Med.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / T32 CA009659-16; None / None / / R01 CA137060-01A1; United States / NCI NIH HHS / CA / T32 CA009659; United States / NCI NIH HHS / CA / R01 CA090321; United States / NCI NIH HHS / CA / R01CA090321; United States / NCI NIH HHS / CA / R21 CA152497; None / None / / R01 CA137060-02; None / None / / R01 CA139032-01; United States / NCI NIH HHS / CA / R01CA137060; United States / NCI NIH HHS / CA / R01 CA139032-02; None / None / / R01 CA139032-02; United States / NCI NIH HHS / CA / R01 CA139032-01; United States / NCI NIH HHS / CA / R21 CA152497-01; United States / NCI NIH HHS / CA / R01 CA137060-02; United States / NCI NIH HHS / CA / R01 CA137060-01A1; None / None / / R21 CA152497-01; United States / NCI NIH HHS / CA / R01 CA139032; United States / NCI NIH HHS / CA / R01CA139032; United States / NCI NIH HHS / CA / R01 CA137060
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / B cell linker protein; 0 / IKZF1 protein, human; 0 / Pre-B Cell Receptors; 148971-36-2 / Ikaros Transcription Factor
[Other-IDs]
NLM/ PMC2722172
12.
Uphoff CC, Denkmann SA, Steube KG, Drexler HG:
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J Biomed Biotechnol
; 2010;2010:904767
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[Title]
Detection of EBV, HBV, HCV, HIV-1,
HTLV
-I and -II, and SMRV in
human
and other primate
cell
lines.
The high prevalence of contaminated
cell
cultures suggests that viral contaminations might be distributed among cultures.
We investigated more than 460 primate
cell
lines for Epstein-Barr (EBV), hepatitis B (HBV), hepatitis C (HCV),
human
immunodeficiency
virus
type 1 (HIV-1),
human
T-
cell leukemia
/
lymphoma
virus I
and II (
HTLV
-I/-II), and squirrel monkey retrovirus (SMRV) infections for risk assessment.
None of the
cell
lines were infected with HCV, HIV-1, or
HTLV
-I/-II.
However, one
cell
line displayed reverse transcriptase activity.
Thirty-nine
cell
lines harbored EBV DNA sequences.
Studies on the lytic phase of EBV revealed that five
cell
lines produce EBV particles and six further
cell
lines produced EBV upon stimulation.
One
cell
line contained an integrated HBV genome fragment but showed
no virus
production.
Six
cell
lines were SMRV-infected.
Newly established
cell
lines should be tested for EBV infections to detect B-lymphoblastoid
cell
lines (B-LCL).
B-LCLs established with EBV from
cell
line B95-8 should be tested for SMRV infections.
[MeSH-major]
Primates / virology.
Viruses
/ genetics.
Viruses
/ isolation & purification
[MeSH-minor]
Animals. Blotting, Southern.
Cell
Line. DNA, Circular / analysis. HIV-1 / genetics. HIV-1 / isolation & purification. Hepacivirus / genetics. Hepacivirus / isolation & purification. Hepatitis B
virus
/ genetics. Hepatitis B
virus
/ isolation & purification. Herpesvirus 4,
Human
/ genetics. Herpesvirus 4,
Human
/ isolation & purification.
Human
T-
lymphotropic virus
1 / genetics.
Human
T-
lymphotropic virus
1 / isolation & purification.
Human
T-
lymphotropic virus
2 / genetics.
Human
T-
lymphotropic virus
2 / isolation & purification. Humans. In Situ Hybridization, Fluorescence. Polymerase Chain Reaction. Retroviruses, Simian / genetics. Retroviruses, Simian / isolation & purification. Saimiri / virology. Viral Proteins / analysis
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(PMID = 20454443.001).
[ISSN]
1110-7251
[Journal-full-title]
Journal of biomedicine & biotechnology
[ISO-abbreviation]
J. Biomed. Biotechnol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Circular; 0 / Viral Proteins
[Other-IDs]
NLM/ PMC2861168
13.
Okudaira T, Hirashima M, Ishikawa C, Makishi S, Tomita M, Matsuda T, Kawakami H, Taira N, Ohshiro K, Masuda M, Takasu N, Mori N:
A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines.
Int J Cancer
; 2007 May 15;120(10):2251-61
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[Title]
A modified version of galectin-9 suppresses
cell
growth and induces apoptosis of
human
T-
cell leukemia
virus
type I-infected T-
cell
lines.
ATL
is a fatal malignancy of T lymphocytes caused by
HTLV
-I infection and remains incurable.
Galectins are a family of animal lectins that function both extracellularly (by interacting with
cell
surface and extracellular matrix glycoproteins and glycolipids) and intracellularly (by interacting with cytoplasmic and nuclear proteins) to modulate signaling pathways.
We found that protease-resistant galectin-9 by modification of its linker peptide, hG9NC(null), prevented
cell
growth of
HTLV
-I-infected T-
cell
lines and primary
ATL
cells.
The suppression of
cell
growth was inhibited by lactose, but not by sucrose, indicating that beta-galactoside binding is essential for hG9NC(null)-induced
cell
growth suppression. hG9NC(null) induced
cell
cycle arrest by reducing the expression of cyclin D1, cyclin D2, cyclin B1, Cdk1, Cdk4, Cdk6, Cdc25C and c-Myc, and apoptosis by reducing the expression of XIAP, c-IAP2 and survivin.
Most of these genes are regulated by NF-kappaB, which plays a critical role in oncogenesis by
HTLV
-I. hG9NC(null) suppressed IkappaBalpha phosphorylation, resulting in suppression of NF-kappaB.
Most importantly, treatment with hG9NC(null) (6.7 mg/kg injected intraperitoneally every day) reduced tumor formation from an
HTLV
-I-infected T-
cell
line when these cells were inoculated subcutaneously into SCID mice.
Our results suggest that hG9NC(null) could be a suitable agent for the management of
ATL
.
[MeSH-major]
Apoptosis / drug effects. Galectins / pharmacology.
HTLV
-I Infections / drug therapy.
Human
T-
lymphotropic virus
1 / growth & development.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ therapy. T-Lymphocytes / pathology. T-Lymphocytes / virology
[MeSH-minor]
Animals. Caspases / metabolism.
Cell
Cycle / drug effects.
Cell
Cycle / physiology.
Cell
Line, Tumor. Female. Galactosides / metabolism. Growth Inhibitors / pharmacology. Humans. Membrane Proteins. Mice. Mice, SCID. NF-kappa B / genetics. NF-kappa B / immunology. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Receptors,
Virus
/ biosynthesis. beta-Galactosidase / metabolism
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[Copyright]
(c) 2007 Wiley-Liss, Inc.
[RetractionIn]
Int J Cancer. 2011 Dec 1;129(11):2762-3
[
21960263.001
]
(PMID = 17278100.001).
[ISSN]
0020-7136
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
[Publication-country]
United States
[Chemical-registry-number]
0 / Galactosides; 0 / Galectins; 0 / Growth Inhibitors; 0 / HAVCR2 protein, human; 0 / LGALS8 protein, human; 0 / LGALS9 protein, human; 0 / Membrane Proteins; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / Receptors, Virus; 0 / beta-galactoside; EC 3.2.1.23 / beta-Galactosidase; EC 3.4.22.- / Caspases
14.
Iino M:
[Severe liver injury following nelarabine chemotherapy for T-cell lymphoblastic lymphoma].
Rinsho Ketsueki
; 2009 Jan;50(1):49-51
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[Title]
[Severe liver injury following nelarabine chemotherapy for T-
cell
lymphoblastic
lymphoma
].
A 41-year-old man received allogeneic hematopoietic stem
cell
transplantation for T-
cell
lymphoblastic
lymphoma
.
[MeSH-major]
Antineoplastic Agents / adverse effects. Arabinonucleosides / adverse effects. Drug-Induced Liver Injury / etiology.
Lymphoma
, T-
Cell
/ drug therapy. Mediastinal Neoplasms / drug therapy. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ drug therapy
[MeSH-minor]
Adult
. Humans. Male. Neoplasm Recurrence, Local. Severity of Illness Index
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(PMID = 19225230.001).
[ISSN]
0485-1439
[Journal-full-title]
[Rinshō ketsueki] The Japanese journal of clinical hematology
[ISO-abbreviation]
Rinsho Ketsueki
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Arabinonucleosides; 60158CV180 / nelarabine
15.
Peloponese JM, Yeung ML, Jeang KT:
Modulation of nuclear factor-kappaB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammation.
Immunol Res
; 2006;34(1):1-12
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[Title]
Modulation of nuclear factor-kappaB by
human
T cell leukemia
virus
type 1 Tax protein: implications for oncogenesis and inflammation.
Human
T cell leukemia
virus
type 1 (
HTLV
-1) is the causative agent of a fatal malignancy known as
adult T cell leukemia
(
ATL
) and an inflammatory
disease
named tropical spastic paraparesis/
HTLV
-
1 associated
myelopathy (TSP/HAM).
HTLV
-1 encodes an oncoprotein, Tax, which plays a significant role in the initiation of cellular transformation and the elicitation of the host's inflammatory responses.
[MeSH-major]
Cell
Transformation, Neoplastic / immunology. Gene Products, tax / immunology.
HTLV
-I Infections / immunology.
Human
T-
lymphotropic virus
1 / immunology. Inflammation / immunology. NF-kappa B / immunology
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(PMID = 16720895.001).
[ISSN]
0257-277X
[Journal-full-title]
Immunologic research
[ISO-abbreviation]
Immunol. Res.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Gene Products, tax; 0 / NF-kappa B
[Number-of-references]
102
16.
Sargent JT, Smith OP:
Haematological emergencies managing hypercalcaemia in adults and children with haematological disorders.
Br J Haematol
; 2010 May;149(4):465-77
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Hypercalcaemia is a common metabolic complication of malignant
disease
often requiring emergency intervention.
Although it is more frequently
associated
with solid tumours, malignancy-
associated
hypercalcaemia (MAH) is seen in a significant number of patients with blood diseases.
Its association with myeloma and
adult T
-
cell
leukaemia
/
lymphoma
is well recognized but the incidence of hypercalcaemia in other haematological neoplasms, affecting adults and children, is less clearly defined.
Haematologists need to be familiar with the
clinical
manifestations of, the differential
diagnosis
to be considered and the most effective management strategies that are currently available for MAH.
[MeSH-minor]
Adult
. Bone Density Conservation Agents / therapeutic use. Child. Diphosphonates / therapeutic use. Fluid Therapy / methods. Humans
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(PMID = 20377591.001).
[ISSN]
1365-2141
[Journal-full-title]
British journal of haematology
[ISO-abbreviation]
Br. J. Haematol.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Bone Density Conservation Agents; 0 / Diphosphonates
[Number-of-references]
96
17.
Marzano AV, Vezzoli P, Fanoni D, Venegoni L, Berti E:
Primary cutaneous T-cell lymphoma expressing FOXP3: a case report supporting the existence of malignancies of regulatory T cells.
J Am Acad Dermatol
; 2009 Aug;61(2):348-55
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[Title]
Primary cutaneous T-
cell lymphoma
expressing FOXP3: a case report supporting the existence of malignancies of regulatory T cells.
Regulatory T (Treg) cells, which represent 5% to 10% of peripheral T cells, regulate the activities of T-
cell
subsets by performing immunosuppressive functions and thus preventing the development of autoimmune responses.
Recently, it has been demonstrated that the tumor cells in
adult T
-
cell leukemia
lymphomas
can function as Treg, raising the question of whether any variant of primary cutaneous T-
cell lymphoma
may also express a regulatory phenotype.
We describe an extraordinary case of primary cutaneous T-
cell lymphoma
clinically characterized by protean cutaneous manifestations and histologically showing a pattern consistent with epidermotropic pleomorphic medium-/large-
cell
primary cutaneous T-
cell lymphoma
.
[MeSH-major]
CD4-
Positive
T-Lymphocytes / immunology. Forkhead Transcription Factors / immunology.
Lymphoma
, T-
Cell
, Cutaneous / pathology. Skin Neoplasms / pathology. T-Lymphocytes, Regulatory / immunology
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.
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(PMID = 19615546.001).
[ISSN]
1097-6787
[Journal-full-title]
Journal of the American Academy of Dermatology
[ISO-abbreviation]
J. Am. Acad. Dermatol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers; 0 / Forkhead Transcription Factors
18.
Miyano-Kurosaki N, Kira J, Barnor JS, Maeda N, Misawa N, Kawano Y, Tanaka Y, Yamamoto N, Koyanagi Y:
Autonomous proliferation of HTLV-CD4+ T cell clones derived from human T cell leukemia virus type I (HTLV-I)-associated myelopathy patients.
Microbiol Immunol
; 2007;51(2):235-42
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[Title]
Autonomous proliferation of
HTLV
-CD4+
T cell
clones
derived
from
human
T cell leukemia
virus
type I (
HTLV
-I)-
associated
myelopathy patients.
That
HTLV
-I infects CD4(+) T cells and enhances their
cell
growth has been shown as successful long-term in vitro proliferation in the presence of IL-2.
It is known that T cells isolated from HAM patients possess strong ability for
cell
proliferation in vitro and mRNA of various cytokines are abundantly expressed in CNS tissues of HAM patients.
In this study, we examined the relationship between
cell
proliferation and ability of in vitro cytokine production of CD4(+)
T cell
clones isolated from HAM patients.
We started a culture from a single
cell
to isolate
cell
clones immediately after drawing blood from the patients using limiting dilution method, which could allow the
cell
to avoid in vitro
HTLV
-I infection after initiation of culture.
Many
cell
clones were obtained and the rate of proliferation efficiency from a single
cell
was as high as 80%, especially in the 4 weeks' culture cells from HAM patients.
Our results indicate that the ability of
cell
proliferation in HAM patients is not restricted in
HTLV
-I-infected T cells.
HTLV
-Iuninfected CD4(+) T cells, mainly Th0 cells, also have a strong ability to respond to IL-2-stimulation, showing that unusual immune activation on T cells has been observed in HAM patients.
[MeSH-major]
CD4-
Positive
T-Lymphocytes / immunology. CD4-
Positive
T-Lymphocytes / virology.
Human
T-
lymphotropic virus
1 / immunology. Paraparesis, Tropical Spastic / immunology
[MeSH-minor]
Adult
. Aged. Clone Cells. Cytokines / genetics. Cytokines / immunology. DNA, Viral / chemistry. DNA, Viral / genetics. Female. Humans. Lymphocyte Activation. Male. Middle Aged. Polymerase Chain Reaction. Receptors, Antigen, T-
Cell
/ immunology
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(PMID = 17310092.001).
[ISSN]
0385-5600
[Journal-full-title]
Microbiology and immunology
[ISO-abbreviation]
Microbiol. Immunol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Japan
[Chemical-registry-number]
0 / Cytokines; 0 / DNA, Viral; 0 / Receptors, Antigen, T-Cell
19.
Kalaycio M, Rybicki L, Pohlman B, Sobecks R, Andresen S, Kuczkowski E, Bolwell B:
Risk factors before autologous stem-cell transplantation for lymphoma predict for secondary myelodysplasia and acute myelogenous leukemia.
J Clin Oncol
; 2006 Aug 1;24(22):3604-10
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[Title]
Risk factors before autologous stem-
cell
transplantation for
lymphoma
predict for secondary myelodysplasia and
acute
myelogenous
leukemia
.
PURPOSE: The risk factors for treatment-related myelodysplastic syndrome (t-MDS) and
acute
myelogenous
leukemia
(AML) after autologous stem-
cell
transplantation (ASCT) are similar to those that increase the risk of difficult stem-
cell
harvests.
We reviewed our experience in 526 patients with
lymphoma
treated by ASCT to determine whether difficult stem-
cell
harvests predict for an increased risk of t-MDS/AML.
Pretransplantation characteristics, including age,
diagnosis
of non-Hodgkin's
lymphoma
or Hodgkin's
disease
, bone marrow involvement, prior radiation therapy, prior exposure to chemotherapy, lactate dehydrogenase at the time of ASCT,
disease
status, and method of stem-
cell
mobilization, were then analyzed with respect to the subsequent development of t-MDS/AML.
[MeSH-major]
Leukemia
, Myeloid,
Acute
/ etiology.
Lymphoma
/ surgery. Myelodysplastic Syndromes / etiology. Peripheral Blood Stem
Cell
Transplantation
[MeSH-minor]
Actuarial Analysis. Adolescent.
Adult
. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Granulocyte Colony-Stimulating Factor / administration & dosage. Hematopoietic Stem
Cell
Mobilization / methods. Humans. Incidence. Male. Middle Aged. Multivariate Analysis. Predictive Value of Tests. Retrospective Studies. Risk Factors. Survival Analysis. Transplantation, Autologous
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.
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NCI CPTC Antibody Characterization Program
.
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(PMID = 16877727.001).
[ISSN]
1527-7755
[Journal-full-title]
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
[ISO-abbreviation]
J. Clin. Oncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
143011-72-7 / Granulocyte Colony-Stimulating Factor
20.
Nobre V, Guedes AC, Martins ML, Barbosa-Stancioli EF, Serufo JC, Proietti FA, Ribas JG, Ferreira CE, Lambertucci JR, GIPH Interdisciplinary Group on HTLV-1/2 Research:
Dermatological findings in 3 generations of a family with a high prevalence of human T cell lymphotropic virus type 1 infection in Brazil.
Clin Infect Dis
; 2006 Nov 15;43(10):1257-63
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[Title]
Dermatological findings in 3 generations of a family with a high prevalence of
human
T cell
lymphotropic virus
type 1 infection in Brazil.
BACKGROUND: Dermatologic manifestations are quite common in patients with
adult T cell leukemia
and
lymphoma
and patients with myelopathy and/or tropical spastic paraparesis
associated
with
human
T cell
lymphotropic virus
type 1 (
HTLV
-1).
The aim of this study was to investigate dermatological findings presented by 30 members of a Brazilian family, half of whom are infected with
HTLV
-1 (as confirmed by enzyme-linked immunosorbent assay and Western blot).
METHODS: The subjects underwent dermatologic examination and laboratory assessment, which included the search for the
HTLV
-1 genome in peripheral blood mononuclear cells (PBMCs) by qualitative and semiquantitative polymerase chain reaction (PCR) and in skin samples by nested qualitative PCR and immunofluorescence assay.
One
HTLV
-1-infected individual presented with concurrently acquired ichthyosis, impetigo, scabies, dermatophytosis, and seborrheic dermatitis.
Additionally, the
HTLV
-1 proviral load was higher in patients with >1 skin lesion.
Finally,
HTLV
-1 could be identified in the skin by immunofluorescence assay, which, by use of PCR as the gold standard, showed a sensitivity and specificity of 61.5% and 100%, respectively.
CONCLUSIONS: Altogether, these
clinical
and laboratory findings point to an
HTLV
-1 tropism toward the skin, even in
HTLV
-1 carriers without
adult T cell leukemia
/
lymphoma
or
HTLV
-1-
associated
myelopathy and/or tropical spastic paraparesis.
[MeSH-major]
HTLV
-I Infections / epidemiology.
Human
T-
lymphotropic virus
1
[MeSH-minor]
Adult
. Brazil / epidemiology. Carrier State / virology. Family Health. Female. Humans.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ etiology. Male. Paraparesis, Tropical Spastic / etiology. Polymerase Chain Reaction. Skin Diseases / epidemiology. Skin Diseases / physiopathology
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(PMID = 17051489.001).
[ISSN]
1537-6591
[Journal-full-title]
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
[ISO-abbreviation]
Clin. Infect. Dis.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
21.
Nagasaki A, Miyagi T, Taira T, Shinhama A, Kojya S, Suzuki M, Aonahata M, Yoshimi N, Takasu N:
Adult T-cell leukemia/lymphoma with multiple integration of HTLV-1 provirus presenting as an isolated paranasal sinus tumor: a case report.
Head Neck
; 2008 Jun;30(6):815-20
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[Title]
Adult T
-
cell leukemia
/
lymphoma
with multiple integration of
HTLV
-1 provirus presenting as an isolated paranasal sinus tumor: a case report.
BACKGROUND:
Adult T
-
cell leukemia
/
lymphoma
(
ATLL
) is a highly aggressive T-
cell lymphoma
and etiologically
associated
with
human
T-
lymphotropic virus
type 1 (
HTLV
-1).
Patients with
ATLL
commonly present with leukemic changes, systemic lymphadenopathy, and/or extranodal lesion and have very poor prognosis.
METHODS AND RESULTS: We describe a rare case of
ATLL
presenting as an isolated paranasal mass.
Southern blot analysis of the biopsied specimens demonstrated multiple integration bands of
HTLV
-1 provirus of different intensities.
Thereafter, the patient showed an indolent
clinical
course with leukemic changes and pulmonary and cutaneous
ATLL
lesions and remains alive more than 5 years from
diagnosis
.
CONCLUSION:
ATLL
should be included in the differential
diagnosis
of sinonasal
lymphoma
, although the event is rare.
Multiple
HTLV
-1 provirus integrations of different intensities may be indicative of good prognosis for
ATLL
.
[MeSH-major]
Human
T-
lymphotropic virus
1 / physiology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/
diagnosis
. Paranasal Sinus Neoplasms /
diagnosis
. Proviruses / physiology
[MeSH-minor]
Adult
. Humans. Male.
Virus
Integration
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(PMID = 18023035.001).
[ISSN]
1043-3074
[Journal-full-title]
Head & neck
[ISO-abbreviation]
Head Neck
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
22.
Tanaka Y, Nakasone H, Yamazaki R, Sato K, Sato M, Terasako K, Kimura S, Okuda S, Kako S, Oshima K, Tanihara A, Nishida J, Yoshikawa T, Nakatsura T, Sugiyama H, Kanda Y:
Single-cell analysis of T-cell receptor repertoire of HTLV-1 Tax-specific cytotoxic T cells in allogeneic transplant recipients with adult T-cell leukemia/lymphoma.
Cancer Res
; 2010 Aug 1;70(15):6181-92
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[Title]
Single-
cell
analysis of T-
cell
receptor repertoire of
HTLV
-1 Tax-specific cytotoxic T cells in allogeneic transplant recipients with
adult T
-
cell leukemia
/
lymphoma
.
Adult T
-
cell leukemia
(
ATL
) is a lymphoproliferative malignancy
associated
with
human
T-
cell
lymphotropic virus
type 1 (
HTLV
-1) infection.
Recently, it has been shown that allogeneic hematopoietic stem
cell
transplantation (allo-HSCT) is an effective treatment for
ATL
, and that
HTLV
-1 Tax-specific CD8(+) cytotoxic T cells (CTL) contribute to the graft-versus-
ATL
effect.
In the present study, we, for the first time, analyzed the T-
cell
receptor (TCR) repertoire of isolated Tax(301-309) (SFHSLHLLF)-specific CTLs in HLA-A*2402(+)
ATL
patients before and after allo-HSCT by single-
cell
reverse transcription-PCR.
In addition, a unique conserved amino acid motif of "P-D/P-R" in TCR-beta complementarity-determining region 3 in either BV7- or BV18-expressing CTLs was observed not only in all of the samples from
ATL
patients, but also in samples from the same patient before and after HSCT.
Furthermore, the P-D/P-R motif-bearing CTL clones established from peripheral blood samples after HSCT exhibited strong killing activity against the
HTLV
-1-infected T cells of the patient.
Hence, Tax(301-309)-specific CTLs in
ATL
patients might have a preference for TCR construction and induce strong immune responses against the
HTLV
-1-infected T cells of patients, which contribute to the graft-versus-
ATL
effects after allo-HSCT.
[MeSH-major]
Gene Products, tax / immunology. Hematopoietic Stem
Cell
Transplantation.
Human
T-
lymphotropic virus
1 / immunology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ immunology. T-Lymphocytes, Cytotoxic / immunology
[MeSH-minor]
Amino Acid Motifs. HLA-A Antigens / immunology. HLA-A24 Antigen. Humans. Peptide Fragments / immunology. Receptors, Antigen, T-
Cell
/ immunology. Receptors, Antigen, T-
Cell
, alpha-beta / immunology
Immune Epitope Database and Analysis Resource.
gene/protein/disease-specific - Related Immune Epitope Information
.
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Cited by Patents in
.
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(PMID = 20647322.001).
[ISSN]
1538-7445
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Gene Products, tax; 0 / HLA-A Antigens; 0 / HLA-A*24:02 antigen; 0 / HLA-A24 Antigen; 0 / Peptide Fragments; 0 / Receptors, Antigen, T-Cell; 0 / Receptors, Antigen, T-Cell, alpha-beta; 0 / tax protein, Human T-lymphotrophic virus 1
23.
Waldmann TA:
Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey.
J Clin Immunol
; 2007 Jan;27(1):1-18
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[Title]
Anti-Tac (daclizumab, Zenapax) in the treatment of
leukemia
, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey.
In addition, we demonstrated that daclizumab is of value in the treatment of patients with noninfectious uveitis, multiple sclerosis, and the neurological
disease human
T-
cell
lymphotropic virus I associated
myelopathy/tropical spastic paraparesis (HAM/TSP).
Others demonstrated therapeutic efficacy with daclizumab in patients with pure red
cell
aplasia, aplastic anemia, and psoriasis.
Thus, translation of basic insights concerning the IL-2/IL-2 receptor system obtained using the monoclonal antibody daclizumab provided a useful strategy for the prevention of organ allograft rejection and the treatment of patients with select autoimmune diseases or T-
cell leukemia
/
lymphoma
.
[MeSH-major]
Antibodies, Monoclonal / therapeutic use. Autoimmune Diseases / drug therapy. Graft Rejection / prevention & control. Immunoglobulin G / therapeutic use. Immunosuppressive Agents / therapeutic use.
Leukemia
/ drug therapy. Receptors, Interleukin-2 / drug effects
[MeSH-minor]
Animals. Antibodies, Monoclonal, Humanized. Binding, Competitive / immunology. Humans. Interleukin-2 / antagonists & inhibitors. Interleukin-2 / immunology. Interleukin-2 Receptor alpha Subunit / antagonists & inhibitors. Interleukin-2 Receptor alpha Subunit / immunology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ drug therapy. Mice. Paraparesis, Tropical Spastic / drug therapy. Uveitis / drug therapy
Genetic Alliance.
consumer health - Autoimmune Diseases
.
MedlinePlus Health Information.
consumer health - Autoimmune Diseases
.
MedlinePlus Health Information.
consumer health - Leukemia
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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Cited by Patents in
.
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[ISSN]
0271-9142
[Journal-full-title]
Journal of clinical immunology
[ISO-abbreviation]
J. Clin. Immunol.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural; Review
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Immunoglobulin G; 0 / Immunosuppressive Agents; 0 / Interleukin-2; 0 / Interleukin-2 Receptor alpha Subunit; 0 / Receptors, Interleukin-2; CUJ2MVI71Y / daclizumab
[Number-of-references]
94
24.
Goldstone AH, Rowe JM:
Transplantation in adult ALL.
Hematology Am Soc Hematol Educ Program
; 2009;:593-601
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[Title]
Transplantation in
adult
ALL.
The value of the allogeneic graft-versus-
leukemia
effect in
adult
acute
lymphoblastic
leukemia
(ALL) has now been conclusively demonstrated and confirmed.
While this is true for adults in all age groups, it may not be the best
clinical
option for young adults for whom increasingly intensive pediatric protocols are clearly of benefit.
As in childhood ALL minimal residual
disease
studies may be extremely useful in predicting outcome and, therefore, strategy, but at present there are less definite data in adults.
Clinical
indications to harness the allogeneic effect will mature as the true value of pediatric protocols in
adult
patients and the safety and efficacy of a sibling, unrelated and reduced intensity transplant emerge in this
disease
.
Genetic Alliance.
consumer health - Transplantation
.
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(PMID = 20008244.001).
[ISSN]
1520-4383
[Journal-full-title]
Hematology. American Society of Hematology. Education Program
[ISO-abbreviation]
Hematology Am Soc Hematol Educ Program
[Language]
ENG
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Neoplasm Proteins
[Number-of-references]
44
25.
Smith A, Roman E, Howell D, Jones R, Patmore R, Jack A, Haematological Malignancy Research Network:
The Haematological Malignancy Research Network (HMRN): a new information strategy for population based epidemiology and health service research.
Br J Haematol
; 2010 Mar;148(5):739-53
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The Haematological Malignancy Research Network (HMRN) was established in 2004 to provide robust generalizable data to inform
clinical
practice and research.
With an emphasis on primary-source data, prognostic factors, sequential treatment/response history, and socio-demographic details are recorded to
clinical
trial standards.
HMRN captures all diagnoses (
adult
and paediatric) and the diagnostic age ranged from 4 weeks to 99 years (median 70.4 years).
In line with published estimates, first-line
clinical
trial entry varied widely by
disease
subtype and age, falling from 59.5% in those aged <15 years to 1.9% in those aged over 75 years - underscoring the need for contextual population-based treatment and response data of the type collected by HMRN.
The critical importance of incorporating molecular and prognostic markers into comparative survival analyses is illustrated with reference to diffuse-large B-
cell lymphoma
,
acute
myeloid
leukaemia
and myeloma.
[MeSH-minor]
Adolescent.
Adult
. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Health Services Research. Humans. Infant. Infant, Newborn. Male. Middle Aged. Young
Adult
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[ISSN]
1365-2141
[Journal-full-title]
British journal of haematology
[ISO-abbreviation]
Br. J. Haematol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC3066245
[Investigator]
Ackroyd S; Ali S; Allsup D; Ashcroft J; Bashi R; Bond L; Bynoe G; Bowen D; Carter C; Chapple M; Ciepluch H; Cook G; Cuthbert A; Czyz J; Edwards A; Feyler S; Gilleece M; Gilson D; Hall C; Harris E; Hill A; Hill Q; Hillmen P; Howard M; Jalihal S; Johnson R; Kinsey S; Kraemer D; Kwok-Williams M; Mcverry T; Moreton P; Munro L; Newton L; Norfolk D; Parapia L; Patil K; Patmore R; Richards M; Sayala H; Sherton G; Smith G; Speed K; Steed A; Subash C; Thomas E; Williams A; Wieczorek A; Wright D; Barrans S; Blythe D; Burton C; Cullen M; Dickinson H; Evans P; Jack A; Jones R; O'Connor S; Owen R; Rawstron A; Richards S; Swirsky D; Tooze R; Worrillow L; Ansell P; Blase J; Cope I; Cox H; Crouch S; Curson W; Doughty J; Farish J; Griffiths S; Howell D; James B; Johnston T; Kane E; Lewis C; Lightfoot T; Newton R; Oliver S; O'Sullivan J; Painter D; Roman E; Simpson J; Sinclair V; Smith A; Thomson A
26.
Tözsér J, Weber IT:
The protease of human T-cell leukemia virus type-1 is a potential therapeutic target.
Curr Pharm Des
; 2007;13(12):1285-94
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[Title]
The protease of
human
T-
cell leukemia
virus
type-1 is a potential therapeutic target.
Human
T-
cell leukemia
virus
type-1 (
HTLV
-1) is
associated
with a number of
human
diseases.
Although the mechanism by which the
virus
causes diseases is still not known, studies indicate that viral replication is critical for the development of
HTLV
-
1 associated
myelopathy, and initial studies suggested that blocking replication with reverse transcriptase inhibitors had a therapeutic effect.
Therefore, based on the success of HIV-1 protease inhibitors, the
HTLV
-1 protease is also a potential target for chemotherapy.
Furthermore, mutated residues in HIV-1 protease that confer drug resistance are frequently seen in equivalent positions of other retroviral proteases, like
HTLV
-1 protease.
Therefore, comparison of
HTLV
-1 and HIV-1 proteases is expected to aid the rational design of broad spectrum inhibitors effective against various retroviral proteases, including the mutant HIV-1 enzymes appearing in drug resistance.
This review describes the characteristics of
HTLV
-1 protease, makes comparison with HIV-1 protease, and discusses the status of inhibitor development for the
HTLV
-1 protease.
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(PMID = 17504236.001).
[ISSN]
1873-4286
[Journal-full-title]
Current pharmaceutical design
[ISO-abbreviation]
Curr. Pharm. Des.
[Language]
ENG
[Grant]
United States / NIGMS NIH HHS / GM / R01 GM062920; United States / NIGMS NIH HHS / GM / GM 062920; United States / FIC NIH HHS / TW / TW01001
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Protease Inhibitors; EC 3.4.23.- / Aspartic Acid Endopeptidases; EC 3.4.23.- / HTLV-1 protease
[Number-of-references]
45
27.
Kannagi M:
[Immunological aspects of human retrovirus infection].
Nihon Rinsho
; 2005 Apr;63 Suppl 4:508-16
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[Title]
[Immunological aspects of
human
retrovirus infection].
[MeSH-major]
HIV Infections / immunology. HIV-1.
HTLV
-I Infections / immunology
[MeSH-minor]
AIDS Vaccines. Animals. Antiretroviral Therapy, Highly Active.
Human
T-
lymphotropic virus
1 / genetics.
Human
T-
lymphotropic virus
1 / immunology. Humans.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ immunology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ physiopathology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ therapy. Mutation. Paraparesis, Tropical Spastic / immunology. Paraparesis, Tropical Spastic / physiopathology. Paraparesis, Tropical Spastic / therapy. Receptors, CCR5 / genetics. Risk
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(PMID = 15861703.001).
[ISSN]
0047-1852
[Journal-full-title]
Nihon rinsho. Japanese journal of clinical medicine
[ISO-abbreviation]
Nippon Rinsho
[Language]
jpn
[Publication-type]
Journal Article; Review
[Publication-country]
Japan
[Chemical-registry-number]
0 / AIDS Vaccines; 0 / Receptors, CCR5
[Number-of-references]
60
28.
Tsukasaki K:
[ATL].
Rinsho Ketsueki
; 2010 Oct;51(10):1595-606
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[Title]
[
ATL
].
[MeSH-major]
Leukemia
-
Lymphoma
,
Adult T
-
Cell
[MeSH-minor]
Adult
. Humans
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(PMID = 20962495.001).
[ISSN]
0485-1439
[Journal-full-title]
[Rinshō ketsueki] The Japanese journal of clinical hematology
[ISO-abbreviation]
Rinsho Ketsueki
[Language]
jpn
[Publication-type]
Journal Article; Review
[Publication-country]
Japan
29.
Aiello A, Fattorusso E, Luciano P, Menna M, Calzado MA, Muñoz E, Bonadies F, Guiso M, Sanasi MF, Cocco G, Nicoletti R:
Synthesis of structurally simplified analogues of aplidinone A, a pro-apoptotic marine thiazinoquinone.
Bioorg Med Chem
; 2010 Jan 15;18(2):719-27
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The study evidenced one of the synthetic analogues (11) as a potent cytotoxic and pro-apoptotic agent against several tumor
cell
lines which also inhibits the TNFalpha-induced NF-kappaB activation in
a human
leukemia T cell
line.
[MeSH-minor]
Animals.
Cell
Line, Tumor.
Cell
Proliferation / drug effects. Computer Simulation. Drug Screening Assays, Antitumor. Humans. Molecular Structure. NF-kappa B / metabolism. Structure-Activity Relationship. Tumor Necrosis Factor-alpha / antagonists & inhibitors. Tumor Necrosis Factor-alpha / pharmacology
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[Copyright]
Copyright 2009 Elsevier Ltd. All rights reserved.
(PMID = 20031419.001).
[ISSN]
1464-3391
[Journal-full-title]
Bioorganic & medicinal chemistry
[ISO-abbreviation]
Bioorg. Med. Chem.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / NF-kappa B; 0 / Quinones; 0 / Tumor Necrosis Factor-alpha; 0 / aplidinone A
30.
Gómez-Acevedo H, Li MY:
Backward bifurcation in a model for HTLV-I infection of CD4+ T cells.
Bull Math Biol
; 2005 Jan;67(1):101-14
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[Title]
Backward bifurcation in a model for
HTLV
-I infection of CD4+ T cells.
Human
T-
cell
Lymphotropic Virus
Type I (
HTLV
-I) primarily infects CD4+ helper T cells.
HTLV
-I infection is clinically linked to the development of
Adult T
-
cell Leukemia
/
Lymphoma
and of
HTLV
-
I Associated
Myelopathy/Tropical Spastic Paraparesis, among other illnesses.
HTLV
-I transmission can be either horizontal through
cell
-to-
cell
contact, or vertical through mitotic division of infected CD4+ T cells.
It has been observed that
HTLV
-I infection has a high proviral load but a low rate of proviral genetic variation.
We consider and analyze a mathematical model for
HTLV
-I infection of CD4+ T cells that incorporates both horizontal and vertical transmission.
[MeSH-major]
CD4-
Positive
T-Lymphocytes / virology. Computer Simulation.
Human
T-
lymphotropic virus
1 / growth & development. Models, Biological
[MeSH-minor]
Algorithms.
Cell
Death.
Cell
Proliferation. Humans
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(PMID = 15691541.001).
[ISSN]
0092-8240
[Journal-full-title]
Bulletin of mathematical biology
[ISO-abbreviation]
Bull. Math. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
31.
Yoshie O:
Expression of CCR4 in adult T-cell leukemia.
Leuk Lymphoma
; 2005 Feb;46(2):185-90
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[Title]
Expression of CCR4 in
adult T
-
cell leukemia
.
Adult T
-
cell leukemia
(
ATL
) is a malignancy of mature T cells that is etiologically
associated
with
human
T-
cell leukemia
virus
type 1 (
HTLV
-1).
The frequent manifestation of
ATL
is infiltration of leukemic cells into various organs.
Besides certain
cell
adhesion molecules and matrix metalloproteineses, chemokine receptors may play important roles in tissue infiltration of
ATL
.
Identification of a unique set of chemokine receptors expressed by
ATL
would thus provide valuable information about the molecular mechanism of tissue infiltration of
ATL
.
This may also reveal that
ATL
frequently develops from a certain subset of T cells that express a particular set of chemokine receptors.
Since
HTLV
-1 encodes a potent viral transcriptional activator Tax, which is known to induce various cellular genes, expression of some chemokine receptors may be affected by Tax.
This, however, may relate more to
HTLV
-1-infected T cells, since
ATL
cells usually do not express Tax.
Finally, identification of a unique set of chemokine receptors expressed by
ATL
may also provide a new therapeutic target.
These considerations prompted us to examine the chemokine receptor expression in
ATL
.
We found that in the majority of
ATL
cases, leukemic cells consistently express CCR4.
Since CCR4 is known to be involved in
T cell
migration into skin, this may in part explain the frequent skin infiltration in
ATL
.
Thus, the majority of
ATL
may predominantly originate from either Th2 or regulatory T cells.
[MeSH-major]
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ immunology. Receptors, Chemokine / analysis
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(PMID = 15621800.001).
[ISSN]
1042-8194
[Journal-full-title]
Leukemia & lymphoma
[ISO-abbreviation]
Leuk. Lymphoma
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
0 / CCR4 protein, human; 0 / Receptors, CCR4; 0 / Receptors, Chemokine
[Number-of-references]
44
32.
van Imhoff GW, van der Holt B, MacKenzie MA, Ossenkoppele GJ, Wijermans PW, Kramer MH, van 't Veer MB, Schouten HC, van Marwijk Kooy M, van Oers MH, Raemaekers JM, Sonneveld P, Meulendijks LA, Kluin PM, Kluin-Nelemans HC, Verdonck LF, Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON):
Short intensive sequential therapy followed by autologous stem cell transplantation in adult Burkitt, Burkitt-like and lymphoblastic lymphoma.
Leukemia
; 2005 Jun;19(6):945-52
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[Title]
Short intensive sequential therapy followed by autologous stem
cell
transplantation in
adult
Burkitt, Burkitt-like and lymphoblastic
lymphoma
.
The feasibility and efficacy of up-front high-dose sequential chemotherapy followed by autologous stem
cell
transplantation (ASCT) in previously untreated adults (median age 33 years; range 15-64) with Burkitt
lymphoma
(BL), Burkitt-like
lymphoma
(BLL) or lymphoblastic
lymphoma
(LyLy), both without central nervous system or extensive bone marrow involvement was investigated in a multicenter phase II study.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Burkitt
Lymphoma
/ drug therapy. Hematopoietic Stem
Cell
Transplantation. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ drug therapy
[MeSH-minor]
Adolescent.
Adult
. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / adverse effects. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / adverse effects. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Agents, Phytogenic / adverse effects. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Doxorubicin / administration & dosage. Doxorubicin / adverse effects. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mitoxantrone / administration & dosage. Mitoxantrone / adverse effects. Prednisone / administration & dosage. Prednisone / adverse effects. Transplantation, Autologous
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.
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.
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(PMID = 15800666.001).
[ISSN]
0887-6924
[Journal-full-title]
Leukemia
[ISO-abbreviation]
Leukemia
[Language]
eng
[Publication-type]
Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BZ114NVM5P / Mitoxantrone; VB0R961HZT / Prednisone
33.
Hieshima K, Nagakubo D, Nakayama T, Shirakawa AK, Jin Z, Yoshie O:
Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells.
J Immunol
; 2008 Jan 15;180(2):931-9
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[Title]
Tax-inducible production of CC chemokine ligand 22 by
human
T cell leukemia
virus
type 1 (
HTLV
-1)-infected T cells promotes preferential transmission of
HTLV
-1 to CCR4-expressing CD4+ T cells.
Adult T cell leukemia
is a mature CD4+
T cell
malignancy which predominantly expresses CCR4 and is etiologically
associated
with
human
T cell leukemia
virus
type 1 (
HTLV
-1).
Because
HTLV
-1 transmission depends on close
cell
-
cell
contacts,
HTLV
-1-infected T cells may preferentially interact with CCR4+CD4+ T cells for efficient viral transmission.
In terms of gene expression and protein secretion, we found a strong correlation between
HTLV
-1 Tax oncoprotein and CCL22, a CCR4 ligand, in
HTLV
-1-infected T cells.
Transient Tax expression in an
HTLV
-1-negative
T cell
line activated the CCL22 promoter and induced CCL22.
In chemotaxis assays, the culture supernatants of
HTLV
-1-infected T cells selectively attracted CCR4+CD4+ T cells in PBMCs.
Finally, anti-CCL22 Ab treatment also blocked
HTLV
-1 transmission to primary CD4+ T cells in coculture experiments with
HTLV
-1 producer cells.
Thus,
HTLV
-1-infected T cells produce CCL22 through Tax and selectively interact with CCR4+CD4+ T cells, resulting in preferential transmission of
HTLV
-1 to CCR4+CD4+ T cells.
[MeSH-major]
CD4-
Positive
T-Lymphocytes / virology. Chemokine CCL22 / genetics. Gene Expression Regulation, Viral. Gene Products, tax / metabolism.
Human
T-
lymphotropic virus
1 / physiology.
Virus
Internalization
[MeSH-minor]
Cell
Adhesion / drug effects.
Cell
Adhesion / genetics.
Cell
Line. Humans. Pertussis Toxin / pharmacology. RNA, Messenger / metabolism. RNA, Small Interfering / pharmacology. Receptors, CCR4 / antagonists & inhibitors. Receptors, CCR4 / metabolism. T-Lymphocytes / immunology. T-Lymphocytes / virology
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.
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[ErratumIn]
J Immunol. 2008 Jun 15;180(12):8470
(PMID = 18178833.001).
[ISSN]
0022-1767
[Journal-full-title]
Journal of immunology (Baltimore, Md. : 1950)
[ISO-abbreviation]
J. Immunol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / CCL22 protein, human; 0 / CCR4 protein, human; 0 / Chemokine CCL22; 0 / Gene Products, tax; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Receptors, CCR4; EC 2.4.2.31 / Pertussis Toxin
34.
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V:
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
Cell Death Differ
; 2005 Aug;12 Suppl 1:905-15
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[Title]
The
human
T-
cell leukemia
virus
type 1 p13II protein: effects on mitochondrial function and
cell
growth.
p13(II) of
human
T-
cell leukemia
virus
type 1 (
HTLV
-1) is an 87-amino-acid protein that is targeted to the inner mitochondrial membrane. p13(II) alters mitochondrial membrane permeability, producing a rapid, membrane potential-dependent influx of K(+).
At the cellular level, p13(II) has been found to interfere with
cell
proliferation and transformation and to promote apoptosis induced by ceramide and Fas ligand.
Assays carried out in T cells (the major targets of
HTLV
-1 infection in vivo) demonstrate that p13(II)-mediated sensitization to Fas ligand-induced apoptosis can be blocked by an inhibitor of Ras farnesylation, thus implicating Ras signaling as a downstream target of p13(II) function.
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[Cites]
Nat Rev Mol Cell Biol. 2003 May;4(5):373-84
[
12728271.001
]
[Cites]
Biochem Biophys Res Commun. 2003 May 9;304(3):575-81
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12729592.001
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12719519.001
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(PMID = 15761473.001).
[ISSN]
1350-9047
[Journal-full-title]
Cell death and differentiation
[ISO-abbreviation]
Cell Death Differ.
[Language]
ENG
[Grant]
United States / PHS HHS / / 100730; United States / FIC NIH HHS / TW / TW005705-03; United States / FIC NIH HHS / TW / TW 05705; United States / FIC NIH HHS / TW / R03 TW005705; United States / FIC NIH HHS / TW / R03 TW005705-01A1; United States / FIC NIH HHS / TW / TW005705-01A1; United States / FIC NIH HHS / TW / TW005705-02; United States / FIC NIH HHS / TW / R03 TW005705-03; United States / FIC NIH HHS / TW / R03 TW005705-02
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Retroviridae Proteins; 0 / rof protein, Human T-lymphotropic virus 1; 0 / tof protein, Human T-lymphotropic virus 1; SY7Q814VUP / Calcium
[Number-of-references]
84
[Other-IDs]
NLM/ NIHMS183534; NLM/ PMC3057663
35.
Luczyński W, Krawczuk-Rybak M, Stasiak-Barmuta A:
[Experimental and selected clinical aspects of active immunotherapy in leukemia].
Postepy Hig Med Dosw (Online)
; 2006;60:379-86
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[Title]
[Experimental and selected
clinical
aspects of active immunotherapy in
leukemia
].
The aim of the review is to summarize current knowledge concerning active immunotherapy in
leukemia
.
The molecular mechanisms and selected
clinical
implications of different cancer vaccines used in pediatric and
adult
leukemias
are discussed.
Cells of
acute
lymphoblastic
leukemia
and chronic lymphocytic
leukemia
can be induced into antigen-presenting cells with the CD40 ligation system.
In many studies it was confimed that these cells stimulate auto- and/or allogeneic T-
cell
response.
Similar effects using different cytokines such as GM-CSF, TNF-alpha, and IL-4 can be observed in
acute
myeloid
leukemia
and myelodysplastic syndromes.
Clinical
experience with such vaccines is limited, but the results of some preliminary reports are quite promising.
MedlinePlus Health Information.
consumer health - Leukemia
.
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(PMID = 16885908.001).
[ISSN]
1732-2693
[Journal-full-title]
Postepy higieny i medycyny doswiadczalnej (Online)
[ISO-abbreviation]
Postepy Hig Med Dosw (Online)
[Language]
POL
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Poland
[Chemical-registry-number]
0 / Cancer Vaccines
[Number-of-references]
51
36.
Gong SL, Qiu HY, Li JY, Han FL, Song XM, Huang ZX, Wang JM:
[Clinical and laboratory characteristics of two acute lymphoblastic leukemia patients with dicentric (9; 20) (p11 - 13; q11)].
Zhonghua Xue Ye Xue Za Zhi
; 2006 May;27(5):306-9
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[Title]
[
Clinical
and laboratory characteristics of two
acute
lymphoblastic
leukemia
patients with dicentric (9; 20) (p11 - 13; q11)].
OBJECTIVE: To explore the
morphologic
, immunophenotypic, cytogenetic and
clinical
features of
acute
lymphoblastic
leukemia
(ALL) patients with dicentric (9;.
RESULTS: The two ALL patients were
positive
for CD10 and HLA-DR, showing of B
cell
origin.
q11) is a rare recurring chromosome
abnormality associated
with ALL.
Because of the subtle nature of the translocation, FISH is essential for the detection of this
abnormality
.
[MeSH-major]
Chromosomes,
Human
, Pair 20 / genetics. Chromosomes,
Human
, Pair 9 / genetics. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ genetics. Translocation, Genetic
[MeSH-minor]
Adult
. Base Sequence. Chromosome Banding. Female. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Male. Middle Aged. Molecular Sequence Data. Sequence Analysis, DNA
Genetic Alliance.
consumer health - Acute Lymphoblastic Leukemia
.
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(PMID = 16875578.001).
[ISSN]
0253-2727
[Journal-full-title]
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
[ISO-abbreviation]
Zhonghua Xue Ye Xue Za Zhi
[Language]
chi
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
China
37.
Poiré X, Kline J, Grinblatt D, Zimmerman T, Conner K, Muhs C, Gajewski T, Van Besien K, Smith SM:
Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas.
Leuk Lymphoma
; 2010 Jul;51(7):1241-50
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[Title]
Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem
cell
transplant in patients with relapsed or refractory
lymphomas
.
High-dose chemotherapy followed by autologous stem
cell
transplant (ASCT) leads to durable remissions in approximately half of patients with chemosensitive relapsed or refractory aggressive
lymphomas
; however, many will relapse despite ASCT secondary to persistent minimal residual
disease
(MRD) or malignant graft contamination.
Forty-six patients with relapsed non-Hodgkin
lymphoma
(NHL) or Hodgkin
lymphoma
(HL) were enrolled.
Genetic Alliance.
consumer health - Factor II Deficiency
.
MedlinePlus Health Information.
consumer health - Hodgkin Disease
.
Hazardous Substances Data Bank.
RITUXIMAB
.
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(PMID = 20496994.001).
[ISSN]
1029-2403
[Journal-full-title]
Leukemia & lymphoma
[ISO-abbreviation]
Leuk. Lymphoma
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / K24 CA116471; United States / NCI NIH HHS / CA / K23CA133196; United States / NCI NIH HHS / CA / K24CA116471
[Publication-type]
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Interleukin-2; 4F4X42SYQ6 / Rituximab; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
38.
Lyell V, Khatamzas E, Allain T:
Severe hypercalcaemia and lymphoma in an HTLV-1 positive Jamaican woman: a case report.
J Med Case Rep
; 2007;1:56
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[Title]
Severe hypercalcaemia and
lymphoma
in an
HTLV
-
1 positive
Jamaican woman: a case report.
Human
T cell
lymphotrophic virus
type-1 infection is endemic in the Afro-Caribbean community in Britain, with carriage rates of about 3%.
Although there is a long latency, carriers have
a 1
-5% chance of developing
adult T cell
leukaemia
/
lymphoma
, a condition frequently complicated by marked and refractory hypercalcaemia, and with a poor prognosis.
We present the case of an elderly Jamaican woman with severe hypercalcaemia and a raised PTHrP who was found to have
lymphoma
and was
positive
for
HTLV
-1.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[ISSN]
1752-1947
[Journal-full-title]
Journal of medical case reports
[ISO-abbreviation]
J Med Case Rep
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC1950877
39.
Schlecht-Louf G, Renard M, Mangeney M, Letzelter C, Richaud A, Ducos B, Bouallaga I, Heidmann T:
Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses.
Proc Natl Acad Sci U S A
; 2010 Feb 23;107(8):3782-7
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Here, we genetically "switched off' the envelope-mediated immunosuppression of an infectious retrovirus, the Friend murine
leukemia
virus
, while preserving mutant envelope infectivity both ex vivo and in vivo, thus allowing us to test the functional importance of envelope-mediated immunosuppression in retrovirus physiology.
Remarkably, we show, in vivo, that the non-IS mutant
virus
displays the same propagation kinetics as its WT counterpart in irradiated immunocompromised mice but that it is rapidly and totally cleared from normal immunocompetent mice, which become fully protected against a challenge with the WT retrovirus.
Using
cell
depletion strategies, we further establish that envelope-mediated immunosuppression enables the retrovirus to escape innate (natural killer cells) and adaptive (CD8 T cells) antiviral effectors.
In conclusion, our work demonstrates the critical role of Env-induced immunosuppression for retrovirus propagation in vivo and identifies a unique definite target for antiretroviral therapies and vaccine strategies, also characterized in the
human
T-
cell leukemia
virus
(
HTLV
) and xenotropic murine
leukemia
virus
-related
virus
(XMRV) retroviruses, opening unprecedented prospects for the treatment of retroviral diseases.
[MeSH-major]
Friend murine
leukemia
virus
/ immunology. Immune Tolerance.
Leukemia
, Experimental / immunology. Retroviridae Infections / immunology. Tumor
Virus
Infections / immunology. Viral Envelope Proteins / immunology. Virulence Factors / immunology
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
The Lens.
Cited by Patents in
.
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(PMID = 20142478.001).
[ISSN]
1091-6490
[Journal-full-title]
Proceedings of the National Academy of Sciences of the United States of America
[ISO-abbreviation]
Proc. Natl. Acad. Sci. U.S.A.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Viral Envelope Proteins; 0 / Viral Vaccines; 0 / Virulence Factors
[Other-IDs]
NLM/ PMC2840525
40.
Lu B, Li Q, Zou DH, Zhao YZ, Qi JY, Xu Y, Qui LG:
[Analysis of clinical feature and treatment outcome in 42 patients with lymphoblastic lymphoma].
Zhonghua Xue Ye Xue Za Zhi
; 2009 Jul;30(7):446-9
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[Title]
[Analysis of
clinical
feature and treatment outcome in 42 patients with lymphoblastic
lymphoma
].
OBJECTIVE: To investigate the
clinical
features and treatment outcomes of different regimens in Chinese patients with lymphoblastic
lymphoma
(LBL).
The RR and CR rates in patients treated with regimens for ALL (ALL-like group) and those treated with regimens for NHL (NHL-like group) were 94.4%, 68.4% and 83.3%, 52.6%, respectively. (3) The estimated median overall survival (OS) and progression free survival (PFS) of hematopoietic stem
cell
transplantation (HSCT) group were significant longer than those of ALL-like group (P=0.018, P=0.025) and NHL-like group (P=0.016, P=0.011).
[MeSH-major]
Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ therapy
[MeSH-minor]
Adolescent.
Adult
. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young
Adult
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.
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(PMID = 21678570.001).
[ISSN]
0253-2727
[Journal-full-title]
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
[ISO-abbreviation]
Zhonghua Xue Ye Xue Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
41.
Nicot C, Harrod RL, Ciminale V, Franchini G:
Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions.
Oncogene
; 2005 Sep 5;24(39):6026-34
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[Title]
Human
T-
cell leukemia
/
lymphoma
virus
type 1 nonstructural genes and their functions.
The
human
T-
cell leukemia
/
lymphoma
virus
(
HTLV
) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3' end originally designated pX.
To date, we know that this region encodes two essential transcriptional and post-transcriptional
positive
regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue).
[MeSH-major]
Human
T-
lymphotropic virus
1 / genetics. Viral Nonstructural Proteins / genetics
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(PMID = 16155609.001).
[ISSN]
0950-9232
[Journal-full-title]
Oncogene
[ISO-abbreviation]
Oncogene
[Language]
eng
[Grant]
United States / NIAID NIH HHS / AI / R01 AI058944; United States / NCI NIH HHS / CA / R01 CA106258
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Viral Nonstructural Proteins
[Number-of-references]
54
42.
Patronas M, Smith JA, Levy-Clarke GA, Reed GF, Buggage RR:
Hypergammaglobulinemia and corneal opacities in patients with human T-cell lymphotrophic virus type-1.
Am J Ophthalmol
; 2006 Dec;142(6):1088-9
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[Title]
Hypergammaglobulinemia and corneal opacities in patients with
human
T-
cell
lymphotrophic virus
type-1.
PURPOSE: To investigate the relationship between serum immunoglobulin levels and corneal opacities in a cohort of patients with
human
T-
cell
lymphotrophic virus
type-1 (
HTLV
-1).
METHODS: Complete ophthalmologic examination was performed on 44 patients with
HTLV
-1 infection (25 patients with
adult T
-
cell leukemia
/
lymphoma
[
ATL
], 18 patients with
HTLV
-1 that was
associated
myelopathy/tropical spastic paraparesis [HAM/TSP], and one patient who was asymptomatic).
RESULTS: Corneal opacities were identified in 15 of 25 patients (60%) with
ATL
and five of 18 patients (28%) with HAM/TSP.
The prevalence of corneal opacities was
associated
statistically with elevated IgG level (P = .023) in patients with
ATL
, but not in patients with HAM/TSP (P > .99).
CONCLUSION: Although the mechanism remains unclear, hypergammaglobulinemia is
associated
with the development of the corneal opacities in patients of African descent with
ATL
.
[MeSH-major]
Corneal Opacity / etiology.
HTLV
-I Infections / complications. Hypergammaglobulinemia / etiology
[MeSH-minor]
Human
T-
lymphotropic virus
1 / isolation & purification. Humans. Immunoglobulin A / blood. Immunoglobulin G / blood. Immunoglobulin M / blood. Nephelometry and Turbidimetry. Prevalence. Retrospective Studies
NCI CPTAC Assay Portal.
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.
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(PMID = 17157606.001).
[ISSN]
0002-9394
[Journal-full-title]
American journal of ophthalmology
[ISO-abbreviation]
Am. J. Ophthalmol.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Immunoglobulin A; 0 / Immunoglobulin G; 0 / Immunoglobulin M
43.
Wada T, Yoshinaga E, Oiso N, Kawara S, Kawada A, Kozuka T:
Adult T-cell leukemia-lymphoma associated with follicular mucinosis.
J Dermatol
; 2009 Dec;36(12):638-42
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[Title]
Adult T
-
cell leukemia
-
lymphoma
associated
with follicular mucinosis.
Follicular mucinosis (alopecia mucinosa) is often
associated
with malignancies including mycosis fungoides and Sézary syndrome, but not
adult T
-
cell leukemia
-
lymphoma
(
ATLL
).
The patient showed 11% of flower-shaped atypical lymphocytes in blood examination and
positive human
T-
cell leukemia
virus
type 1 antibody in serology, consistent with the chronic type of
ATLL
.
This case seems to be a very rare association of follicular mucinosis and chronic
ATLL
, suggesting that malignant T cells may have a feature of folliculotropism as well as epidermotropism.
[MeSH-major]
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ complications. Mucinosis, Follicular / complications
[MeSH-minor]
DNA, Viral / genetics. DNA, Viral / isolation & purification.
Human
T-
lymphotropic virus
1 / genetics.
Human
T-
lymphotropic virus
1 / isolation & purification. Humans. Male. Middle Aged
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(PMID = 19958447.001).
[ISSN]
1346-8138
[Journal-full-title]
The Journal of dermatology
[ISO-abbreviation]
J. Dermatol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / DNA, Viral
44.
Shahnaz S, Reich D, Arévalo-Valencia D, Kucinska S, Tulczynska J, Fleischman J:
HTLV-1-associated adult T cell leukemia lymphoma presenting as granulomatous pneumocystis jiroveci pneumonia (PJP) and hypercalcemia.
J Gen Intern Med
; 2007 Mar;22(3):420-3
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[Title]
HTLV
-1-
associated
adult T cell leukemia lymphoma
presenting as granulomatous pneumocystis jiroveci pneumonia (PJP) and hypercalcemia.
BACKGROUND: Since the initial description of
human
T cell
lymphotropic virus
(
HTLV
-1), clusters of this infection have been detected globally.
Unlike HIV infection, most patients infected with
HTLV
-1 remain asymptomatic throughout their lifetime.
CASE REPORT: We report the case of a 39-year-old Afro-Caribbean man with
HTLV
-1 infection presenting as hypercalcemia and granulomatous pneumocystis jiroveci pneumonia.
HTLV
-1-
associated
adult T cell leukemia lymphoma
(
ATLL
) was diagnosed in this patient by bone marrow and lymph node biopsy.
This is believed to be the first description of this type of reaction to pneumocystis jiroveci in
a HTLV
-1-infected
ATLL
patient.
[MeSH-major]
HTLV
-I Infections /
diagnosis
. Hypercalcemia /
diagnosis
.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/
diagnosis
. Pneumocystis jirovecii. Pneumonia, Pneumocystis /
diagnosis
[MeSH-minor]
Aged.
Diagnosis
, Differential. Female. Humans
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[
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]
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[
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]
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[
8393873.001
]
[Cites]
Clin Infect Dis. 1995 Oct;21(4):1014-6
[
8645790.001
]
(PMID = 17356979.001).
[ISSN]
1525-1497
[Journal-full-title]
Journal of general internal medicine
[ISO-abbreviation]
J Gen Intern Med
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC1824742
45.
Ishii T, Ishida T, Utsunomiya A, Inagaki A, Yano H, Komatsu H, Iida S, Imada K, Uchiyama T, Akinaga S, Shitara K, Ueda R:
Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma.
Clin Cancer Res
; 2010 Mar 1;16(5):1520-31
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[Title]
Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for
adult T
-
cell leukemia
/
lymphoma
.
PURPOSE:
Adult T
-
cell leukemia
/
lymphoma
(
ATLL
) has a very poor prognosis.
The first aim of the present study was to evaluate whether the antitumor activity of KW-0761 would likely be sufficient for therapeutic
clinical
application against
ATLL
.
EXPERIMENTAL DESIGN: The antitumor activity of KW-0761 against
ATLL
cell
lines was evaluated in vitro using
human
cells and in mice in vivo.
Primary
ATLL
cells from 23 patients were evaluated for susceptibility to autologous ADCC with KW-0761 by two independent methods.
RESULTS: KW-0761 showed potent antitumor activity against
ATLL
cell
lines both in vitro and in the
ATLL
mouse model in vivo.
In addition, KW-0761 showed potent antitumor activity mediated by highly enhanced ADCC against primary
ATLL
cells both in vitro and ex vivo in an autologous setting.
The degree of KW-0761 ADCC against primary
ATLL
cells in an autologous setting was mainly determined by the amount of effector natural killer cells present, but not the amount of the target molecule CCR4 on the
ATLL
cell
surface.
CONCLUSION: KW-0761 should be sufficiently active for therapeutic
clinical
application for
ATLL
.
In addition, combination treatment strategies that augment natural killer
cell
activity should be promising for amplifying the effect of KW-0761.
In the near future, the actual efficacy of KW-0761 will be established in pivotal
clinical
trials.
[MeSH-major]
Antibodies, Monoclonal / pharmacology. Antineoplastic Agents / pharmacology. Immunotherapy / methods.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ drug therapy
[MeSH-minor]
Adult
. Animals. Antibodies, Monoclonal, Humanized. Antibody-Dependent
Cell
Cytotoxicity / drug effects. Antibody-Dependent
Cell
Cytotoxicity / immunology. Biosensing Techniques.
Cell
Separation. Flow Cytometry. Humans. Male. Mice. Mice, SCID. Receptors, CCR4 / immunology
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(PMID = 20160057.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / CCR4 protein, human; 0 / Receptors, CCR4; 0 / mogamulizumab
46.
Zhao J, Yin YM, Zhao YL, Sun Y, Wang JB, Zhong J, Zhang X, Fei XH, Shan FX, Liu HX, Wang T, Wang H, Tong CR, Wu T, Lu DP:
[Clinical and molecular biologic characteristics of 36 cases of leukemia with 11q23/mll].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 2010 Dec;18(6):1381-5
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[Title]
[
Clinical
and molecular biologic characteristics of 36 cases of
leukemia
with 11q23/mll].
This study was aimed to analyze the
clinical
and cytogenetic characteristics of
acute
leukemia
with 11q23/mll rearrangement and explore the reasonable therapeutic principles.
Characteristics in general situation, morphology, immunology, molecular biology, cytogenetics, treatment and overall survival of 36 cases of
acute leukemias
with mll gene rearrangement were studied and analyzed.
The results showed that 36 cases with mll gene rearrangement were found
positive
(7.2%) in 494 patients with
acute
leukemia
.
Among the 36 cases of mll rearrangement
positive
, 32 cases were diagnosed as
acute
myeloid
leukemia
(AML) with myeloid antigen expression, of which 5 cases expressed lymphoblastic differentiation antigen; 4 cases were classified as B-lineage
acute
lymphoblastic
leukemia
(ALL), of which non-lineage myeloid expression pattern were found in 3 cases.
Of the responded patients, 10 cases relapsed within 6 months, with a recurrence rate of 40%; 9 cases received hematopoietic stem
cell
transplantation (HSCT), 7 cases of which survived after transplantation.
It is concluded that
acute
leukemia
patients with mll gene rearrangement show poor response to chemotherapy, high recurrence rate and poor prognosis.
Hematopoietic stem
cell
transplantation may be a reasonable treatment principle to improve these patients' survival situation.
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(PMID = 21176334.001).
[ISSN]
1009-2137
[Journal-full-title]
Zhongguo shi yan xue ye xue za zhi
[ISO-abbreviation]
Zhongguo Shi Yan Xue Ye Xue Za Zhi
[Language]
CHI
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
[Chemical-registry-number]
0 / MLL protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase
47.
Basu D, Siddaraju N, Murugan P, Badhe BA, Akkarappatty C, Dutta TK:
Cytologic aspects of T-cell acute lymphoblastic leukemia presenting as a massive pericardial effusion: a case report.
Acta Cytol
; 2009 May-Jun;53(3):337-40
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[Title]
Cytologic aspects of T-
cell
acute
lymphoblastic
leukemia
presenting as a massive pericardial effusion: a case report.
BACKGROUND:
Acute
lymphoblastic
leukemia
(ALL) with a
clinical
presentation of cardiac tamponade and the presence of blasts in the pericardial fluid is an uncommon event.
A cytopathologist needs to adopt a cautious interpretive approach while dealing with a lymphoid-rich pericardial effusion in order to prevent a false negative
diagnosis
.
On detailed
clinical
examination,
a diagnosis
of anemia with cardiac tamponade was made.
A hematologic workup was carried out to exclude
leukemia
/
lymphoma
.
A diagnosis
of T-
cell
acute
lymphoblastic
leukemia
(FAB L1) was offered, and the patient was started on a remission and induction regimen.
The abnormal lymphoid cells found in the pericardial fluid in such situations need to be interpreted cautiously, as their presence is of
clinical
significance.
[MeSH-major]
Cardiac Tamponade / pathology. Pericardial Effusion / pathology. Precursor T-
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ pathology
[MeSH-minor]
Adult
. Antigens, CD3 / analysis. Antineoplastic Combined Chemotherapy Protocols. Biomarkers, Tumor / analysis. Bone Marrow Cells / chemistry. Bone Marrow Cells / pathology. DNA Nucleotidylexotransferase / analysis. Fatal Outcome. Humans. Lymphocytes / chemistry. Lymphocytes / pathology. Male. Periodic Acid-Schiff Reaction. Radiography, Thoracic
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.
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(PMID = 19534280.001).
[ISSN]
0001-5547
[Journal-full-title]
Acta cytologica
[ISO-abbreviation]
Acta Cytol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, CD3; 0 / Biomarkers, Tumor; EC 2.7.7.31 / DNA Nucleotidylexotransferase
48.
Ohkura S, Yamashita M, Ishida T, Babu PG, Koyanagi Y, Yamamoto N, Miura T, Hayami M:
Phylogenetic heterogeneity of new HTLV type 1 isolates from southern India in subgroup A.
AIDS Res Hum Retroviruses
; 2005 Apr;21(4):325-30
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[Title]
Phylogenetic heterogeneity of new
HTLV
type 1 isolates from southern India in subgroup A.
Seven isolates of
human
T cell leukemia
virus
type 1 (
HTLV
-1) were taken in southern India and phylogenetically analyzed to gain new insights into the origin and dissemination of
HTLV
-1 in the subcontinent.
The new Indian
HTLV
-1s were found to be members of subgroup A (Transcontinental subgroup) of the Cosmopolitan group.
These results demonstrate that Indian
HTLV
-1s are genetically heterogeneous and include the most divergent strain of subgroup A.
On the basis of these results, we speculate that subgroup
A HTLV
- 1s may have been present for thousands of years in India.
[MeSH-major]
HTLV
-I Infections / virology.
Human
T-
lymphotropic virus
1 / genetics. Polymorphism, Genetic
[MeSH-minor]
Adult
. Child. DNA, Viral / chemistry. Female. Humans. India. Male. Middle Aged. Molecular Sequence Data. Phylogeny. Sequence Analysis, DNA. Terminal Repeat Sequences / genetics
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(PMID = 15943577.001).
[ISSN]
0889-2229
[Journal-full-title]
AIDS research and human retroviruses
[ISO-abbreviation]
AIDS Res. Hum. Retroviruses
[Language]
eng
[Databank-accession-numbers]
GENBANK/ AY607576/ AY607577/ AY607578/ AY607579/ AY607580/ AY607581/ AY607582
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Viral
49.
Kataoka K, Seo S, Sugawara Y, Ota S, Imai Y, Takahashi T, Fukayama M, Kokudo N, Kurokawa M:
Post-transplant lymphoproliferative disorder after adult-to-adult living donor liver transplant: case series and review of literature.
Leuk Lymphoma
; 2010 Aug;51(8):1494-501
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[Title]
Post-transplant lymphoproliferative
disorder
after
adult
-to-
adult
living donor liver transplant: case series and review of literature.
Post-transplant lymphoproliferative
disorder
(PTLD) is a serious complication of solid organ transplant.
We aimed to determine the
clinical
characteristics of PTLD after LDLT.
We investigated 323 consecutive patients undergoing
adult
-to-
adult
LDLT and identified three patients who developed biopsy-proven PTLD.
All of them were seropositive for Epstein-Barr
virus
(EBV) and had hepatitis
C virus
-related cirrhosis at transplant.
All three patients developed late-onset and monomorphic PTLD, including one diffuse large B-
cell lymphoma
and two Burkitt
lymphomas
with c-myc rearrangement.
We showed a relatively low incidence and distinct clinicopathological features of PTLD after
adult
-to-
adult
LDLT, which might reflect the unique nature of LDLT.
[MeSH-minor]
Adolescent.
Adult
. Aged. Epstein-Barr
Virus
Infections /
diagnosis
. Epstein-Barr
Virus
Infections / virology. Female. Herpesvirus 4,
Human
/ isolation & purification. Humans. Male. Middle Aged. Positron-Emission Tomography. Retrospective Studies. Review Literature as Topic. Survival Rate. Treatment Outcome. Young
Adult
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.
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.
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[CommentIn]
Leuk Lymphoma. 2010 Aug;51(8):1393-4
[
20497000.001
]
(PMID = 20578817.001).
[ISSN]
1029-2403
[Journal-full-title]
Leukemia & lymphoma
[ISO-abbreviation]
Leuk. Lymphoma
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
50.
Linderoth J, Ehinger M, Jerkeman M, Bendahl PO, Akerman M, Berglund M, Enblad G, Erlanson M, Roos G, Cavallin-Ståhl E:
CD40 expression identifies a prognostically favourable subgroup of diffuse large B-cell lymphoma.
Leuk Lymphoma
; 2007 Sep;48(9):1774-9
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[Title]
CD40 expression identifies a prognostically favourable subgroup of diffuse large B-
cell lymphoma
.
In order to confirm our earlier findings of the prognostic effects of CD23 and CD40 expression in diffuse large B-
cell lymphoma
(DLBCL), possibly due to association with the germinal center (GC) phenotype and/or an increased autologous tumour response, tumour specimens from 125 patients with
de
novo DLBCL were investigated for immunohistochemical expression of CD23, CD40, BCL6, CD10, MUM1, CD4 and CD8.
CD40 was
positive
in 64% and was
associated
with improved overall survival (p = 0.03).
A GC phenotype was present in 47%, and was also
associated
with a better overall survival (p = 0.006) but did not correlate with CD40-expression.
CD23 was
positive
in 10% and expression did not correlate with prognosis.
In conclusion, the prognostic effect of CD40 expression was confirmed, but did not correlate with GC-phenotype or T-
cell
infiltration.
[MeSH-major]
Antigens, CD40 / analysis.
Lymphoma
, B-
Cell
/ mortality
[MeSH-minor]
Adolescent.
Adult
. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis
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(PMID = 17786713.001).
[ISSN]
1042-8194
[Journal-full-title]
Leukemia & lymphoma
[ISO-abbreviation]
Leuk. Lymphoma
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antigens, CD40
51.
Quintás-Cardama A, Kantarjian H, Manshouri T, Luthra R, Estrov Z, Pierce S, Richie MA, Borthakur G, Konopleva M, Cortes J, Verstovsek S:
Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera.
J Clin Oncol
; 2009 Nov 10;27(32):5418-24
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Median time from
diagnosis
to PEG-IFN-alpha-2a was 54 months in patients with PV and 33 months in patients with ET.
CONCLUSION: PEG-IFN-alpha-2a resulted in remarkable
clinical
activity, high rates of molecular response, and acceptable toxicity in patients with advanced ET or PV.
[MeSH-minor]
Adolescent.
Adult
. Aged. Humans. Janus Kinase 2 / genetics. Middle Aged. Mutation. Neutropenia / chemically induced. Recombinant Proteins. Treatment Outcome. Young
Adult
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(PMID = 19826111.001).
[ISSN]
1527-7755
[Journal-full-title]
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
[ISO-abbreviation]
J. Clin. Oncol.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / P30 CA016672
[Publication-type]
Clinical Trial, Phase II; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Interferon-alpha; 0 / Recombinant Proteins; 30IQX730WE / Polyethylene Glycols; 47RRR83SK7 / interferon alfa-2a; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2; Q46947FE7K / peginterferon alfa-2a
[Other-IDs]
NLM/ PMC4881362
52.
Phillips AA, Shapira I, Willim RD, Sanmugarajah J, Solomon WB, Horwitz SM, Savage DG, Bhagat G, Soff G, Zain JM, Alobeid B, Seshan VE, O'Connor OA:
A critical analysis of prognostic factors in North American patients with human T-cell lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma: a multicenter clinicopathologic experience and new prognostic score.
Cancer
; 2010 Jul 15;116(14):3438-46
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[Title]
A critical analysis of prognostic factors in North American patients with
human
T-
cell
lymphotropic virus
type-1-
associated
adult T
-
cell leukemia
/
lymphoma
: a multicenter clinicopathologic experience and new prognostic score.
BACKGROUND: To define the clinicopathologic and prognostic features of patients with
human
T-
cell
lymphotropic virus
type-1 (
HTLV
-1)-
associated
adult T
-
cell leukemia
/
lymphoma
(
ATLL
) in North America, standard criteria were used to identify patients with
ATLL
.
The
acute
subtype predominated (68.5%).
Although the International Prognostic Index and Prognostic Index for peripheral T-
cell lymphoma
unspecified identified subsets of patients, these models were not completely predictive.
A recursive partitioning analysis was performed on the data, which successfully identified 3 prognostic categories based on Eastern Cooperative Oncology Group performance status, stage, age, and calcium level at
diagnosis
.
CONCLUSIONS: This series proposed a new prognostic model for patients with
HTLV
-1-
associated ATLL
and confirmed a poor outcome for these patients in North America.
[MeSH-major]
Human
T-
lymphotropic virus
1.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
[MeSH-minor]
Adult
. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Male. Middle Aged. Prognosis. United States
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[Copyright]
Copyright (c) 2010 American Cancer Society.
(PMID = 20564100.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
United States
53.
Hidaka T, Nakahata S, Hatakeyama K, Hamasaki M, Yamashita K, Kohno T, Arai Y, Taki T, Nishida K, Okayama A, Asada Y, Yamaguchi R, Tsubouchi H, Yokota J, Taniwaki M, Higashi Y, Morishita K:
Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma.
Blood
; 2008 Jul 15;112(2):383-93
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[Title]
Down-regulation of TCF8 is involved in the leukemogenesis of
adult T
-
cell leukemia
/
lymphoma
.
Adult T
-
cell leukemia
/
lymphoma
(
ATLL
) is caused by latent
human
T-
lymphotropic virus
-1 (
HTLV
-1) infection.
To clarify the molecular mechanism underlying leukemogenesis after viral infection, we precisely mapped 605 chromosomal breakpoints in 61
ATLL
cases by spectral karyotyping and identified frequent chromosomal breakpoints in 10p11, 14q11, and 14q32.
Single nucleotide polymorphism (SNP) array-comparative genomic hybridization (CGH), genetic, and expression analyses of the genes mapped within a common breakpoint cluster region in 10p11.2 revealed that in
ATLL
cells, transcription factor 8 (TCF8) was frequently disrupted by several mechanisms, including mainly epigenetic dysregulation.
TCF8 mutant mice frequently developed invasive CD4(+) T-
cell
lymphomas
in the
thymus
or in ascitic fluid in vivo.
Down-regulation of TCF8 expression in
ATLL
cells in vitro was
associated
with resistance to transforming growth factor beta1 (TGF-beta1), a well-known characteristic of
ATLL
cells, suggesting that escape from TGF-beta1-mediated growth inhibition is important in the pathogenesis of
ATLL
.
These findings indicate that TCF8 has a tumor suppressor role in
ATLL
.
[MeSH-major]
Homeodomain Proteins / physiology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ etiology. Transcription Factors / physiology. Transforming Growth Factor beta1 / physiology
[MeSH-minor]
Animals. Chromosome Breakage. Chromosomes,
Human
, Pair 10. Chromosomes,
Human
, Pair 14. Down-Regulation / genetics. Humans. Karyotyping. Mice. Tumor Cells, Cultured
KOMP Repository.
gene/protein/disease-specific - KOMP Repository
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Mouse Genome Informatics (MGI).
Mouse Genome Informatics (MGI)
.
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(PMID = 18467597.001).
[ISSN]
1528-0020
[Journal-full-title]
Blood
[ISO-abbreviation]
Blood
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Homeodomain Proteins; 0 / Transcription Factors; 0 / Transforming Growth Factor beta1; 0 / ZEB1 protein, human
54.
Javier RT:
Cell polarity proteins: common targets for tumorigenic human viruses.
Oncogene
; 2008 Nov 24;27(55):7031-46
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[Title]
Cell
polarity proteins: common targets for tumorigenic
human viruses
.
Loss of polarity and disruption of
cell
junctions are common features of epithelial-
derived
cancer cells, and mounting evidence indicates that such defects have a direct function in the pathology of cancer.
Supporting this idea, results with several different
human
tumor
viruses
indicate that their oncogenic potential depends in part on a common ability to inactivate key
cell
polarity proteins.
For example, adenovirus (Ad) type 9 is unique among
human
Ads by causing exclusively estrogen-dependent mammary tumors in experimental animals and in having E4 region-encoded open reading frame 1 (E4-ORF1) as its primary oncogenic determinant.
Most notably, the E4-ORF1 PBM mediates interactions with a selected group of cellular PDZ proteins, three of which include the
cell
polarity proteins Dlg1, PATJ and ZO-2.
Data further indicate that these interactions promote disruption of
cell
junctions and a loss of
cell
polarity.
In addition, one or more of the E4-ORF1-interacting
cell
polarity proteins, as well as the
cell
polarity protein Scribble, are common targets for the high-risk
human
papillomavirus (HPV) E6 or
human
T-
cell leukemia
virus
type 1 (
HTLV
-1) Tax oncoproteins.
Underscoring the significance of these observations, in humans, high-risk HPV and
HTLV
-1 are causative agents for cervical cancer and
adult T
-
cell leukemia
, respectively.
Consequently,
human
tumor
viruses
should serve as powerful tools for deciphering mechanisms whereby disruption of
cell
junctions and loss of
cell
polarity contribute to the development of many
human
cancers.
This review article discusses evidence supporting this hypothesis, with an emphasis on the
human
Ad E4-ORF1 oncoprotein.
[MeSH-major]
Cell
Polarity. Membrane Proteins / physiology. Neoplasms / etiology.
Virus
Attachment.
Virus
Diseases / complications
[MeSH-minor]
Adenovirus Infections,
Human
/ virology. Adenoviruses,
Human
/ physiology. Animals.
Cell
Transformation, Viral / physiology. Gene Products, tax / physiology.
Human
T-
lymphotropic virus
1 / metabolism.
Human
T-
lymphotropic virus
1 / physiology.
Human
papillomavirus 6 / metabolism.
Human
papillomavirus 6 / physiology. Humans. Models, Biological. Oncogene Proteins, Viral / metabolism. Oncogene Proteins, Viral / physiology. Protein Binding
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(PMID = 19029943.001).
[ISSN]
1476-5594
[Journal-full-title]
Oncogene
[ISO-abbreviation]
Oncogene
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / R01 CA058541
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
0 / E4 protein, Adenovirus 9; 0 / Gene Products, tax; 0 / Membrane Proteins; 0 / Oncogene Proteins, Viral; 0 / tax protein, Human T-lymphotrophic virus 1
[Number-of-references]
233
[Other-IDs]
NLM/ NIHMS411909; NLM/ PMC3501650
55.
Sugita S, Takase H, Yoshida T, Sugamoto Y, Watanabe T, Mochizuki M:
Intraocular soluble IL-2 receptor alpha in a patient with adult T cell leukaemia with intraocular invasion.
Br J Ophthalmol
; 2006 Sep;90(9):1204-6
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[Title]
Intraocular soluble IL-2 receptor alpha in a patient with
adult T cell
leukaemia
with intraocular invasion.
[MeSH-major]
Biomarkers, Tumor / analysis. Eye / pathology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ pathology. Leukemic Infiltration / immunology. Receptors, Interleukin-2 / analysis
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.
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[Cites]
Am J Ophthalmol. 2002 Oct;134(4):616-8
[
12383828.001
]
[Cites]
J Lab Clin Med. 1989 Oct;114(4):407-10
[
2794753.001
]
[Cites]
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[
7860769.001
]
[Cites]
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[
8031276.001
]
[Cites]
Rinsho Ketsueki. 1992 Apr;33(4):537-41
[
1318431.001
]
(PMID = 16929066.001).
[ISSN]
0007-1161
[Journal-full-title]
The British journal of ophthalmology
[ISO-abbreviation]
Br J Ophthalmol
[Language]
eng
[Publication-type]
Case Reports; Letter; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / IL2RA protein, human; 0 / Interleukin-2 Receptor alpha Subunit; 0 / Receptors, Interleukin-2
[Other-IDs]
NLM/ PMC1857395
56.
Semmes OJ:
Adult T cell leukemia: a tale of two T cells.
J Clin Invest
; 2006 Apr;116(4):858-60
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[Title]
Adult T cell leukemia
: a tale of two T cells.
Human
T cell leukemia
virus
type 1 (
HTLV
-1) is the etiologic agent for the development of an aggressive hematologic neoplasia termed
adult T cell leukemia
/
lymphoma
(
ATLL
).
Although the
virus
infects
T cell
subsets that display either CD4 or CD8
cell
surface markers, the leukemic
cell
is exclusively of the CD4+ subtype.
In the article by Sibon et al. in this issue of the JCI, the authors demonstrate that the molecular basis for clonal expansion differs between these 2 infected
T cell
populations (see the related article beginning on page 974).
The molecular events
associated
with a preleukemic state, such as genomic instability, polynucleation, and
cell
cycle redistribution, were only observed in CD4+ T cells.
This
finding
provides a molecular-based mechanism for the restriction of the leukemic phenotype to the CD4+
T cell
subtype.
[MeSH-major]
CD4-
Positive
T-Lymphocytes / metabolism. CD8-
Positive
T-Lymphocytes / metabolism.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ pathology
[MeSH-minor]
Adult
. Gene Products, tax / metabolism. Humans. Models, Biological. Phenotype
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[Cites]
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[CommentOn]
J Clin Invest. 2006 Apr;116(4):974-83
[
16585963.001
]
(PMID = 16585953.001).
[ISSN]
0021-9738
[Journal-full-title]
The Journal of clinical investigation
[ISO-abbreviation]
J. Clin. Invest.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / R01 CA076595
[Publication-type]
Comment; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Gene Products, tax
[Other-IDs]
NLM/ PMC1421364
57.
Eckerle S, Brune V, Döring C, Tiacci E, Bohle V, Sundström C, Kodet R, Paulli M, Falini B, Klapper W, Chaubert AB, Willenbrock K, Metzler D, Bräuninger A, Küppers R, Hansmann ML:
Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma.
Leukemia
; 2009 Nov;23(11):2129-38
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[Title]
Gene expression profiling of isolated tumour cells from anaplastic large
cell
lymphomas
: insights into its cellular origin, pathogenesis and relation to Hodgkin
lymphoma
.
Anaplastic large
cell lymphoma
(ALCL) is a main type of T-
cell
lymphomas
and comprises three distinct entities: systemic anaplastic
lymphoma
kinase (ALK)
positive
, systemic ALK(-) and cutaneous ALK(-) ALCL (cALCL).
Little is known about their pathogenesis and their cellular origin, and morphological and immunophenotypical overlap exists between ALK(-) ALCL and classical Hodgkin
lymphoma
(cHL).
We conducted gene expression profiling of microdissected
lymphoma
cells of five ALK(+) and four ALK(-) systemic ALCL, seven cALCL and sixteen cHL, and of eight subsets of normal T and NK cells.
The analysis supports a derivation of ALCL from activated T cells, but the
lymphoma
cells acquired a gene expression pattern hampering an assignment to a CD4(+), CD8(+) or CD30(+) T-
cell
origin.
Indeed, ALCL display a down-modulation of many T-
cell
characteristic molecules.
Surprisingly, few genes are differentially expressed between systemic and cALCL despite their different
clinical
behaviour, and between ALK(-) ALCL and cHL despite their different cellular origin.
[MeSH-major]
Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Hodgkin
Disease
/ genetics.
Lymphoma
, Large-
Cell
, Anaplastic / genetics
[MeSH-minor]
Adolescent.
Adult
. Aged.
Cell
Line. Female. Humans. Immunohistochemistry. Killer Cells, Natural / cytology. Killer Cells, Natural / physiology. Male. Microdissection. Middle Aged. NF-kappa B / metabolism. Phenotype. Protein-Tyrosine Kinases / genetics. Receptor Protein-Tyrosine Kinases. Reverse Transcriptase Polymerase Chain Reaction. T-Lymphocytes / cytology. T-Lymphocytes / physiology. Young
Adult
Genetic Alliance.
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Genetic Alliance.
consumer health - Anaplastic Large Cell Lymphoma
.
Genetic Alliance.
consumer health - Lymphoma, large-cell
.
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.
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(PMID = 19657361.001).
[ISSN]
1476-5551
[Journal-full-title]
Leukemia
[ISO-abbreviation]
Leukemia
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / NF-kappa B; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
58.
Zhang J, Yamada O, Matsushita Y, Chagan-Yasutan H, Hattori T:
Transactivation of human osteopontin promoter by human T-cell leukemia virus type 1-encoded Tax protein.
Leuk Res
; 2010 Jun;34(6):763-8
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[Title]
Transactivation of
human
osteopontin promoter by
human
T-
cell leukemia
virus
type 1-encoded Tax protein.
We report here that OPN gene is transactivated by Tax protein of
human
T-
cell leukemia
virus
type 1 (
HTLV
-1).
This study suggests that OPN is one of the downstream mediators of aberrantly activated PI3K/AKT signaling by Tax, which may partially contribute to
HTLV
-1-
associated
leukemogenesis.
[MeSH-minor]
Base Sequence. Binding Sites. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology.
Cell
Line, Tumor.
Cell
Transformation, Viral / genetics. Gene Expression Regulation, Neoplastic.
Human
T-
lymphotropic virus
1 / genetics.
Human
T-
lymphotropic virus
1 / physiology. Humans. Liver Neoplasms / genetics. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Phosphatidylinositol 3-Kinases / metabolism. Phosphatidylinositol 3-Kinases / physiology. Promoter Regions, Genetic / physiology. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-akt / physiology. Signal Transduction / genetics. Transcription Factor AP-1 / metabolism
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.
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.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[Copyright]
Copyright 2009 Elsevier Ltd. All rights reserved.
(PMID = 19767100.001).
[ISSN]
1873-5835
[Journal-full-title]
Leukemia research
[ISO-abbreviation]
Leuk. Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Gene Products, tax; 0 / Transcription Factor AP-1; 0 / tax protein, Human T-lymphotrophic virus 1; 106441-73-0 / Osteopontin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
59.
Peloponese JM Jr, Yeung ML, Jeang KT:
Modulation of nuclear factor-ϰB by human T cell leukemia virus type 1 tax protein : Implications for oncogenesis and inflammation.
Immunol Res
; 2006 Jan;34(1):1-12
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[Title]
Modulation of nuclear factor-ϰB by
human
T cell leukemia
virus
type 1 tax protein : Implications for oncogenesis and inflammation.
Human
T cell leukemia
virus
type 1 (
HTLV
-1) is the causative agent of a fatal malignancy known as
adult T cell leukemia
(
ATL
) and an inflammatory
disease
named tropical spastic paraparesis/
HTLV
-
1 associated
myelopathy (TSP/HAM).
HTLV
-1 encodes an oncoprotein, Tax, which plays a significant role in the initiation of cellular transformation and the elicitation of the host's inflammatory responses.
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(PMID = 27519575.001).
[ISSN]
0257-277X
[Journal-full-title]
Immunologic research
[ISO-abbreviation]
Immunol. Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Keywords]
NOTNLM ; Adult T cell leukemia (ATL) / HTLV-1 Tax / Human T cell leukemia virus (HTLV-1) / IKK / Inflammation / NF-ϰB / NIK
60.
Tojo A, Usuki K, Urabe A, Maeda Y, Kobayashi Y, Jinnai I, Ohyashiki K, Nishimura M, Kawaguchi T, Tanaka H, Miyamura K, Miyazaki Y, Hughes T, Branford S, Okamoto S, Ishikawa J, Okada M, Usui N, Tanii H, Amagasaki T, Natori H, Naoe T:
A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL.
Int J Hematol
; 2009 Jun;89(5):679-88
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A Phase I/II dose-escalation study was designed to evaluate the efficacy, safety, and pharmacokinetics of nilotinib in Japanese patients with imatinib-resistant or -intolerant Philadelphia chromosome-
positive
(Ph+) chronic myelogenous
leukemia
(CML) or relapsed/refractory Ph+
acute
lymphoblastic
leukemia
(ALL).
[MeSH-major]
Leukemia
, Myelogenous, Chronic, BCR-ABL
Positive
/ drug therapy. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ drug therapy. Pyrimidines / administration & dosage
[MeSH-minor]
Adult
. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Asian Continental Ancestry Group. Benzamides. Drug Resistance, Neoplasm. Female. Fusion Proteins, bcr-abl / antagonists & inhibitors. Humans. Imatinib Mesylate. Male. Middle Aged. Piperazines / pharmacokinetics. Piperazines / toxicity. Protein-Tyrosine Kinases / antagonists & inhibitors. Salvage Therapy. Treatment Outcome
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.
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.
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[Cites]
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Leukemia. 2009 Jun;23(6):1054-61
[
19282833.001
]
(PMID = 19449194.001).
[ISSN]
1865-3774
[Journal-full-title]
International journal of hematology
[ISO-abbreviation]
Int. J. Hematol.
[Language]
eng
[Publication-type]
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide; 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Fusion Proteins, bcr-abl
61.
Tobinai K:
Clinical trials for human T-cell lymphotropic virus type I-associated peripheral T-cell lymphoma in Japan.
Semin Hematol
; 2010 Apr;47 Suppl 1:S5-7
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[Title]
Clinical
trials for
human
T-
cell
lymphotropic virus
type I-
associated
peripheral T-
cell lymphoma
in Japan.
The most common subtype of T-/natural killer (NK)
cell lymphoma
in Japan is
adult T
-
cell leukemia
-
lymphoma
(
ATL
), which is
associated
with the
human
T-
cell
lymphotropic virus
type I (
HTLV
-1).
The investigators in Japan have conducted several
clinical
trials on multi-agent chemotherapy and stem
cell
transplantation for patients with
ATL
.
They have also initiated several new
clinical
trials with a number of agents: an anti-CCR4 antibody, KW-0761; forodesine, a purine nucleoside phosphorylase inhibitor; and lenalidomide, an immunomodulatory agent.
Clinical
trials with pralatrexate, a folate analog, and denileukin diftitox, an immunoconjugate, are under discussion for patients with
ATL
and peripheral T-
cell lymphoma
(PTCL).
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Clinical
Trials as Topic. Hematopoietic Stem
Cell
Transplantation.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ drug therapy
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THALIDOMIDE
.
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[Copyright]
Copyright 2010 Elsevier Inc. All rights reserved.
(PMID = 20359583.001).
[ISSN]
1532-8686
[Journal-full-title]
Seminars in hematology
[ISO-abbreviation]
Semin. Hematol.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Drugs, Investigational; 0 / Immunologic Factors; 0 / Purine Nucleosides; 0 / Pyrimidinones; 0 / mogamulizumab; 426X066ELK / forodesine; 4Z8R6ORS6L / Thalidomide; F0P408N6V4 / lenalidomide
[Number-of-references]
9
62.
Kluin-Nelemans HC, Coenen JL, Boers JE, van Imhoff GW, Rosati S:
EBV-positive immunodeficiency lymphoma after alemtuzumab-CHOP therapy for peripheral T-cell lymphoma.
Blood
; 2008 Aug 15;112(4):1039-41
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[Title]
EBV-
positive
immunodeficiency
lymphoma
after alemtuzumab-CHOP therapy for peripheral T-
cell lymphoma
.
Chemotherapy with alemtuzumab and the combination of cyclophosphamide, adriamycin, oncovin, and prednisone (CHOP) has become experimental trial therapy for aggressive T-
cell lymphoma
.
As part of an ongoing phase 2 trial in which we recently treated 20 patients with 8 cycles of CHOP every 2 weeks with 3 additional doses of 30 mg alemtuzumab per cycle, we observed the development of Epstein-Barr
virus
(EBV)-
positive
lymphoproliferative
disease
, after completion of the immunochemotherapy in 3 patients with peripheral T-
cell lymphoma
.
Because the occurrence of EBV-
positive
lymphoproliferative
disease
is rare after alemtuzumab monotherapy, such as is given for chronic lymphocytic
leukemia
, we think that early reporting of this potential side effect is warranted.
It may be caused by intrinsic T-
cell
defects in patients with T-
cell lymphoma
, or by the combination of alemtuzumab with CHOP chemotherapy.
[MeSH-major]
Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Neoplasm / administration & dosage. Antibodies, Neoplasm / adverse effects. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Herpesvirus 4,
Human
.
Lymphoma
/ chemically induced.
Lymphoma
/ virology.
Lymphoma
, T-
Cell
, Peripheral / drug therapy
[MeSH-minor]
Adult
. Antibodies, Monoclonal, Humanized. Cyclophosphamide. Doxorubicin. Female. Humans. Immunologic Deficiency Syndromes / chemically induced. Male. Middle Aged. Prednisone. Vincristine
Genetic Alliance.
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.
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.
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.
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PREDNISONE
.
Hazardous Substances Data Bank.
VINCRISTINE
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 18502831.001).
[ISSN]
1528-0020
[Journal-full-title]
Blood
[ISO-abbreviation]
Blood
[Language]
eng
[Publication-type]
Case Reports; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antibodies, Neoplasm; 3A189DH42V / alemtuzumab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone
63.
Kuzel TM, Li S, Eklund J, Foss F, Gascoyne R, Abramson N, Schwerkoske JF, Weller E, Horning SJ:
Phase II study of denileukin diftitox for previously treated indolent non-Hodgkin lymphoma: final results of E1497.
Leuk Lymphoma
; 2007 Dec;48(12):2397-402
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[Title]
Phase II study of denileukin diftitox for previously treated indolent non-Hodgkin
lymphoma
: final results of E1497.
Denileukin diftitox (DD) is approved for treatment of CD-25 expressing cutaneous T-
cell
lymphomas
(CTCL).
Initial studies of DD demonstrated responses in patients with B-
cell
non-Hodgkin
lymphoma
(NHL).
This report is on 29 patients (18 males) with indolent B-
cell
NHL (11 IL-2R+ and 18 IL-2R-).
Histologic subtypes included small lymphocytic (SLL) (8 patients) and follicular grade I/II
lymphoma
(21 patients).
[MeSH-major]
Antineoplastic Agents / therapeutic use. Diphtheria Toxin / therapeutic use. Interleukin-2 / therapeutic use.
Lymphoma
, Non-Hodgkin / drug therapy
[MeSH-minor]
Adult
. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Receptors, Interleukin-2 / analysis. Recombinant Fusion Proteins / adverse effects. Recombinant Fusion Proteins / therapeutic use
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.
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.
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.
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.
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.
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.
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(PMID = 17943599.001).
[ISSN]
1042-8194
[Journal-full-title]
Leukemia & lymphoma
[ISO-abbreviation]
Leuk. Lymphoma
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Diphtheria Toxin; 0 / Interleukin-2; 0 / Receptors, Interleukin-2; 0 / Recombinant Fusion Proteins; 25E79B5CTM / denileukin diftitox
64.
Fahim S, Prokopetz R, Jackson R, Faught C, McCarthy AE, Andonov A, Coulthart M, Daw Z, Olberg B, Giulivi A, Padmore R:
Human T-cell lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma in the Inuit people of Nunavut.
CMAJ
; 2006 Sep 12;175(6):579
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[Title]
Human
T-
cell
lymphotropic virus
type 1-
associated
adult T
-
cell leukemia
/
lymphoma
in the Inuit people of Nunavut.
[MeSH-major]
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ ethnology
[MeSH-minor]
Adult
. Aged. Fatal Outcome. Female. Humans. Indians, North American. Lymphocytosis / blood. Medical History Taking. Middle Aged. Physical Examination. Practice Guidelines as Topic
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[Cites]
Tissue Antigens. 1998 Nov;52(5):444-51
[
9864034.001
]
[Cites]
CMAJ. 2006 Jan 17;174(2):150-1
[
16415454.001
]
[Cites]
Am J Hematol. 2005 Mar;78(3):232-9
[
15726602.001
]
(PMID = 16966657.001).
[ISSN]
1488-2329
[Journal-full-title]
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
[ISO-abbreviation]
CMAJ
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Canada
[Other-IDs]
NLM/ PMC1559419
65.
Mesnard JM, Barbeau B, Devaux C:
HBZ, a new important player in the mystery of adult T-cell leukemia.
Blood
; 2006 Dec 15;108(13):3979-82
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[Title]
HBZ, a new important player in the mystery of
adult T
-
cell leukemia
.
Adult T
-
cell leukemia
(
ATL
) was first described in 1977.
A link between
ATL
and
human
T-
cell leukemia
virus
type 1 (
HTLV
-1) was clearly established in the early 1980s.
Over the years, many aspects of
HTLV
-1-induced cellular dysfunctions have been clarified.
However, the detailed mechanism behind
ATL
occurrence remains unsolved.
Presently, we are still unable to explain the absence of viral Tax protein (thought to play a central role in T-
cell
transformation) in more than 50% of
ATL
cells.
A novel
HTLV
-1 HBZ protein, encoded on the negative strand, was characterized by our group and is currently the subject of intensive research efforts to determine its function in viral replication and/or pathophysiology.
Recently, 4 studies reported on the existence of different HBZ isoforms and have investigated on their function in both
ATL
cells or animal models.
[MeSH-major]
Basic-Leucine Zipper Transcription Factors / genetics.
Cell
Transformation, Viral / genetics.
Human
T-
lymphotropic virus
1 / genetics.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ genetics. Viral Proteins / genetics.
Virus
Replication / genetics
[MeSH-minor]
Animals.
Cell
Proliferation.
Disease
Models, Animal. Gene Products, tax / deficiency. Gene Products, tax / immunology. Humans. Protein Isoforms / genetics. Protein Isoforms / immunology. RNA, Messenger / genetics. RNA, Messenger / immunology. RNA, Viral / genetics. RNA, Viral / immunology. T-Lymphocytes / immunology. T-Lymphocytes / pathology. T-Lymphocytes / virology
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(PMID = 16917009.001).
[ISSN]
0006-4971
[Journal-full-title]
Blood
[ISO-abbreviation]
Blood
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Basic-Leucine Zipper Transcription Factors; 0 / Gene Products, tax; 0 / HBZ protein, human T-cell leukemia virus type I; 0 / Protein Isoforms; 0 / RNA, Messenger; 0 / RNA, Viral; 0 / Viral Proteins
[Number-of-references]
102
66.
Ariumi Y, Trono D:
Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function.
J Virol
; 2006 Mar;80(5):2445-52
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[Title]
Ataxia-telangiectasia-mutated (ATM) protein can enhance
human
immunodeficiency
virus
type 1 replication by stimulating Rev function.
The ataxia-telangiectasia-mutated (ATM) kinase plays a central role in responses to various forms of DNA damage and has been suggested to facilitate
human
immunodeficiency
virus
type 1 (HIV-1) integration.
Notably, ATM overexpression did not stimulate the HIV-1 late gene expression within the context of Rev-independent constructs or the Rex-dependent production of capsid from
human
T-
cell leukemia
virus
type 1 proviral constructs.
[MeSH-major]
Cell
Cycle Proteins / physiology. DNA-Binding Proteins / physiology. Gene Expression Regulation, Viral. Gene Products, rev / physiology. HIV-1 / physiology. Protein-Serine-Threonine Kinases / physiology. Tumor Suppressor Proteins / physiology.
Virus
Replication
[MeSH-minor]
Ataxia Telangiectasia Mutated Proteins. Caffeine.
Cell
Line. Gene Silencing. Genes, Reporter. HIV Core Protein p24 / analysis. Humans. Luciferases / analysis. Luciferases / genetics. rev Gene Products,
Human
Immunodeficiency
Virus
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.
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NCI CPTAC Assay Portal
.
eagle-i research resources.
PMID 16474151 (Special Collections)
.
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EMBO J. 1997 Dec 15;16(24):7500-10
[
9405378.001
]
(PMID = 16474151.001).
[ISSN]
0022-538X
[Journal-full-title]
Journal of virology
[ISO-abbreviation]
J. Virol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Gene Products, rev; 0 / HIV Core Protein p24; 0 / Tumor Suppressor Proteins; 0 / rev Gene Products, Human Immunodeficiency Virus; 3G6A5W338E / Caffeine; EC 1.13.12.- / Luciferases; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
[Other-IDs]
NLM/ PMC1395391
67.
Mwakigonja AR, Kaaya EE, Mgaya EM:
Malignant lymphomas (ML) and HIV infection in Tanzania.
J Exp Clin Cancer Res
; 2008;27:9
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[Title]
Malignant
lymphomas
(ML) and HIV infection in Tanzania.
BACKGROUND: HIV infection is reported to be
associated
with some malignant
lymphomas
(ML) so called AIDS-related
lymphomas
(ARL), with an aggressive behavior and poor prognosis.
The ML frequency, pathogenicity,
clinical
patterns and possible association with AIDS in Tanzania, are not well documented impeding the development of preventive and therapeutic strategies.
METHODS: Sections of 176 archival formalin-fixed paraffin-embedded biopsies of ML patients at Muhimbili National Hospital (MNH)/Muhimbili University of Health and Allied Sciences (MUHAS), Tanzania from 1996-2001 were stained for hematoxylin and eosin and selected (70) cases for expression of pan-leucocytic (CD45), B-
cell
(CD20), T-
cell
(CD3), Hodgkin/RS
cell
(CD30), histiocyte (CD68) and proliferation (Ki-67) antigen markers.
Corresponding
clinical
records were also evaluated.
RESULTS: The proportion of ML out of all diagnosed tumors at MNH during the 6 year period was 4.2% (176/4200) comprising 77.84% non-Hodgkin (NHL) including 19.32% Burkitt's (BL) and 22.16% Hodgkin's
disease
(HD).
The ML tumors frequency increased from 0.42% (1997) to 0.70% (2001) and 23.7% of tested sera from these patients were HIV
positive
.
Supra-diaphragmatic presentation was commonest and histological sub-types were mostly aggressive B-
cell
lymphomas
however, no clear cases of primary effusion
lymphoma
(PEL) and primary central nervous system
lymphoma
(PCNSL) were diagnosed.
CONCLUSION: Malignant
lymphomas
apparently, increased significantly among diagnosed tumors at MNH between 1996 and 2001, predominantly among the young, HIV infected and AIDS patients.
The frequent aggressive
clinical
and histological presentation as well as the dominant B-immunophenotype and the HIV serology indicate a pathogenic association with AIDS.
Therefore, routine HIV screening of all malignant
lymphoma
patients at MNH is necessary to enable comprehensive ARL
diagnosis
and formulation of preventive and therapeutic protocols.
[MeSH-major]
HIV Infections / complications.
Lymphoma
, AIDS-Related / epidemiology
[MeSH-minor]
Adolescent.
Adult
. Aged. Aged, 80 and over. Burkitt
Lymphoma
/ epidemiology. Burkitt
Lymphoma
/ etiology. Burkitt
Lymphoma
/ virology. Child. Child, Preschool. Female. HIV Seropositivity. Hodgkin
Disease
/ epidemiology. Hodgkin
Disease
/ etiology. Hodgkin
Disease
/ virology. Humans. Immunohistochemistry.
Lymphoma
, Non-Hodgkin / epidemiology.
Lymphoma
, Non-Hodgkin / etiology.
Lymphoma
, Non-Hodgkin / virology. Male. Middle Aged. Tanzania / epidemiology
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.
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[ISSN]
1756-9966
[Journal-full-title]
Journal of experimental & clinical cancer research : CR
[ISO-abbreviation]
J. Exp. Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Italy
[Other-IDs]
NLM/ PMC2438337
68.
Yoshida M, Satou Y, Yasunaga J, Fujisawa J, Matsuoka M:
Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZIP factor (HBZ) gene.
J Virol
; 2008 Oct;82(19):9359-68
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[Title]
Transcriptional control of spliced and unspliced
human
T-
cell leukemia
virus
type 1 bZIP factor (HBZ) gene.
The
human
T-
cell leukemia
virus
type 1 (
HTLV
-1) basic leucine zipper factor (HBZ) gene is encoded by the minus strand of the
HTLV
-1 provirus and transcribed from the 3' long terminal repeat (LTR).
We compared the functions of the proteins
derived
from the sHBZ and usHBZ transcripts. sHBZ showed a stronger suppression of Tax-mediated transcriptional activation through the 5' LTR than did usHBZ; the level of suppression correlated with the level of protein produced.
The expression of sHBZ had a growth-promoting function in a T-
cell
line, while usHBZ expression did not.
[MeSH-major]
Basic-Leucine Zipper Transcription Factors / chemistry.
Human
T-
lymphotropic virus
1 / genetics. Sp1 Transcription Factor / metabolism. Transcription, Genetic. Viral Proteins / genetics. Viral Proteins / physiology
[MeSH-minor]
Alternative Splicing. Base Sequence.
Cell
Proliferation. Gene Expression Regulation, Viral. Gene Products, tax / metabolism. Humans. Molecular Sequence Data. Promoter Regions, Genetic. RNA, Viral / metabolism. Terminal Repeat Sequences
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Oncogene. 2005 Sep 5;24(39):5976-85
[
16155604.001
]
[Cites]
Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):720-5
[
16407133.001
]
[Cites]
J Virol. 2006 Mar;80(5):2495-505
[
16474156.001
]
[Cites]
Gene. 2006 Feb 1;366(2):335-42
[
16288839.001
]
[Cites]
Blood. 2006 May 15;107(10):3976-82
[
16424388.001
]
[Cites]
Retrovirology. 2006;3:15
[
16512901.001
]
[Cites]
J Virol. 2006 Aug;80(15):7427-38
[
16840323.001
]
[Cites]
J Virol. 2007 Feb;81(4):1543-53
[
17151132.001
]
[Cites]
Nat Rev Cancer. 2007 Apr;7(4):270-80
[
17384582.001
]
[Cites]
Nat Med. 2004 Feb;10(2):197-201
[
14730358.001
]
(PMID = 18653454.001).
[ISSN]
1098-5514
[Journal-full-title]
Journal of virology
[ISO-abbreviation]
J. Virol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Basic-Leucine Zipper Transcription Factors; 0 / Gene Products, tax; 0 / HBZ protein, human T-cell leukemia virus type I; 0 / RNA, Viral; 0 / Sp1 Transcription Factor; 0 / Viral Proteins
[Other-IDs]
NLM/ PMC2546946
69.
Norén-Nyström U, Roos G, Bergh A, Botling J, Lönnerholm G, Porwit A, Heyman M, Forestier E:
Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome.
Leukemia
; 2008 Mar;22(3):504-10
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[Title]
Bone marrow fibrosis in childhood
acute
lymphoblastic
leukemia
correlates to biological factors, treatment response and outcome.
We retrospectively evaluated reticulin fiber density (RFD) in 166 diagnostic bone marrow (BM) biopsies and 62 biopsies obtained at treatment day 29 from children with
acute
lymphoblastic
leukemia
(ALL).
Patients with B-
cell
precursor (BCP)-ALL showed higher RFD as compared to patients with T-
cell
ALL (P<0.001).
RFD correlated negatively with white blood
cell
count (P=0.008) in BCP-ALL patients.
In BCP-ALL patients, RFD at
diagnosis
correlated to the levels of minimal residual
disease
(MRD) analyzed by flow cytometry on treatment day 29 (P=0.001).
Accordingly, patients with MRD > or = 10(-4) presented higher RFD at
diagnosis
compared to patients with MRD < 10(-4) (P=0.003).
BCP-ALL patients with low RFD at
diagnosis
and a rapid reduction of RFD on day 29 had a favorable outcome compared to patients with the same baseline RFD level at
diagnosis
but a slow RFD reduction (P=0.041).
Expanded use of BM biopsy both at
diagnosis
and during follow-up is suggested.
[MeSH-major]
Bone Marrow Examination. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ pathology. Primary Myelofibrosis / pathology. Reticulin / analysis
[MeSH-minor]
Adolescent. Aneuploidy. Biopsy. Child. Child, Preschool. Female. Humans. Infant.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ pathology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ therapy. Male. Neoplasm, Residual. Precursor B-
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ pathology. Precursor B-
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ therapy. Prognosis. Retrospective Studies. Risk Assessment. Survival Analysis. Sweden / epidemiology. Treatment Outcome
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(PMID = 18094715.001).
[ISSN]
1476-5551
[Journal-full-title]
Leukemia
[ISO-abbreviation]
Leukemia
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Reticulin
70.
Han X, Bueso-Ramos CE:
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias.
Am J Clin Pathol
; 2007 Apr;127(4):528-44
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[Title]
Precursor T-
cell
acute
lymphoblastic
leukemia
/lymphoblastic
lymphoma
and
acute
biphenotypic
leukemias
.
Session 4 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop focused on case presentations of precursor T-
cell
acute
lymphoblastic
leukemia
/lymphoblastic
lymphoma
(pre-T ALL/LBL) and
acute
biphenotypic
leukemia
.
Pre-T ALL represents approximately 15% of childhood and 25% of
adult
ALL cases.
HOX11 overexpression may correlate with a good prognosis in
adult
pre-T ALL.
Acute
biphenotypic
leukemias
are characterized by a single population of blasts that express myeloid, T- or B-lineage antigens in various combinations and account for fewer than 4% of
all acute leukemias
.
An accurate
diagnosis
of pre-T ALL/LBL and
acute
biphenotypic
leukemia
requires a multiparametric approach, including examination of
morphologic
features, immunophenotype,
clinical
characteristics, and cytogenetic and molecular findings.
[MeSH-major]
Biomarkers, Tumor / analysis.
Leukemia
, Lymphoid /
diagnosis
. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/
diagnosis
[MeSH-minor]
Chromosome Aberrations.
Diagnosis
, Differential. Gene Expression Profiling. Humans. Immunohistochemistry
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.
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.
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.
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.
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(PMID = 17369128.001).
[ISSN]
0002-9173
[Journal-full-title]
American journal of clinical pathology
[ISO-abbreviation]
Am. J. Clin. Pathol.
[Language]
eng
[Publication-type]
Congresses
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
71.
Patil S, Spencer A, Schwarer A, Lewis I, Hertzberg M, Avery S, Wei A, Noutsos T, Paul E, Taouk Y, Muirhead J:
Reduced-intensity conditioned allogeneic haematopoietic stem cell transplantation results in durable disease-free and overall survival in patients with poor prognosis myeloid and lymphoid malignancies: eighty-month follow-up.
Bone Marrow Transplant
; 2010 Jul;45(7):1154-60
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[Title]
Reduced-intensity conditioned allogeneic haematopoietic stem
cell
transplantation results in durable
disease
-free and overall survival in patients with poor prognosis myeloid and lymphoid malignancies: eighty-month follow-up.
The long-term outcome of patients with haematological malignancies treated with reduced-intensity conditioned allogeneic peripheral blood stem
cell
transplantation is not known.
The diagnoses include AML/myelodysplastic syndrome (n=43), non Hodgkin's
lymphoma
(n=30), Hodgkin's
lymphoma
(n=3), ALL (n=2) and CML (n=1).
For the entire cohort, the
disease
-free survival (DFS) and OS were 61.2 and 35.7%, respectively.
Twenty patients relapsed, 18 within the first three years, and 14 patients succumbed to progressive
disease
.
Day 100 non-relapse mortality correlated with a higher total nucleated
cell
dose in the graft (odds ratio: 3.9).
Furthermore, of 43 patients with active
disease
at the time of transplantation, 16 remained in CR after 3 years.
No post-transplant lymphoproliferative
disorder
was seen.
In conclusion, durable
disease
control was achieved after RIC allogeneic stem
cell
transplantation for patients with advanced myeloid and lymphoid malignancies.
[MeSH-major]
Hematologic Neoplasms / therapy. Hematopoietic Stem
Cell
Transplantation / methods. Transplantation Conditioning / methods
[MeSH-minor]
Adult
. Cause of Death.
Cell
Count. Cohort Studies.
Disease
-Free Survival. Female. Follow-Up Studies. Humans.
Leukemia
, Myeloid / complications.
Leukemia
, Myeloid / mortality.
Leukemia
, Myeloid / therapy. Lymphoproliferative Disorders / complications. Lymphoproliferative Disorders / mortality. Lymphoproliferative Disorders / therapy. Male. Middle Aged. Prognosis. Remission Induction. Survival Analysis. Survival Rate. Treatment Outcome
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(PMID = 19898502.001).
[ISSN]
1476-5365
[Journal-full-title]
Bone marrow transplantation
[ISO-abbreviation]
Bone Marrow Transplant.
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
England
72.
Masutani H, Ueda S, Yodoi J:
The thioredoxin system in retroviral infection and apoptosis.
Cell Death Differ
; 2005 Aug;12 Suppl 1:991-8
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Human
thioredoxin (TRX) was first identified in
human
T-
cell leukemia
virus
type I (
HTLV
-I)-
positive
T-
cell
lines and is
associated
with the pathophysiology of retroviral infections.
Thioredoxin binding protein-2/vitamin D(3) upregulated protein 1 is a growth suppressor and its expression is suppressed in
HTLV
-I-transformed cells.
Studies of these molecules of the TRX system provide novel insights into the apoptosis
associated
with retroviral diseases.
[MeSH-minor]
Animals. Glutathione / metabolism. HIV Infections / metabolism.
HTLV
-I Infections / metabolism. Humans. MAP Kinase Kinase Kinase 5 / metabolism. Membrane Proteins / metabolism. Peroxidases / metabolism. Peroxiredoxins
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(PMID = 15818395.001).
[ISSN]
1350-9047
[Journal-full-title]
Cell death and differentiation
[ISO-abbreviation]
Cell Death Differ.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Membrane Proteins; 52500-60-4 / Thioredoxins; EC 1.11.1.- / Peroxidases; EC 1.11.1.15 / Peroxiredoxins; EC 2.7.11.25 / MAP Kinase Kinase Kinase 5; GAN16C9B8O / Glutathione
[Number-of-references]
93
73.
Candoni A, Michelutti A, Simeone E, Damiani D, Baccarani M, Fanin R:
Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed acute lymphoblastic leukaemia despite expression of multidrug resistance-related proteins.
Eur J Haematol
; 2006 Oct;77(4):293-9
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[Title]
Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed
acute
lymphoblastic
leukaemia
despite expression of multidrug resistance-related proteins.
The treatment of relapsed
adult
acute
lymphoblastic
leukaemia
(ALL) is frequently unsuccessful with current chemotherapy regimens, and often there is an overexpression of multidrug resistance (MDR)-related proteins.
Liposomal encapsulation makes daunorubicin (DNR) less sensitive to the efflux effect of P-glycoprotein (PGP), and in vitro data indicate that liposomal-encapsulated DNR (Daunoxome-DNX) is more toxic than DNR against ALL
cell
lines.
Before the start of DNX therapy, 18/25 (72%) cases overexpressed at least one MDR-related protein compared with 9/25 (36%) cases with MDR overexpression at
diagnosis
(P = 0.01).
Taking into account the small number of cases, the response rate was not affected by MDR expression and the in vitro results also showed a higher uptake and apoptotic
cell
death by DNX compared with DNR.
Moreover, the high rate of remissions and the good
clinical
tolerance in heavily pretreated pts suggest a promising role of DNX in ALL chemotherapy regimens.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Multidrug Resistance-
Associated
Proteins / metabolism. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ drug therapy
[MeSH-minor]
Adolescent.
Adult
. Cytarabine / administration & dosage. Daunorubicin / administration & dosage. Female. Humans. Liposomes. Male. Middle Aged. Recurrence
Hazardous Substances Data Bank.
CYTARABINE
.
Hazardous Substances Data Bank.
DAUNORUBICIN
.
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(PMID = 16856922.001).
[ISSN]
0902-4441
[Journal-full-title]
European journal of haematology
[ISO-abbreviation]
Eur. J. Haematol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Denmark
[Chemical-registry-number]
0 / Liposomes; 0 / Multidrug Resistance-Associated Proteins; 04079A1RDZ / Cytarabine; ZS7284E0ZP / Daunorubicin
74.
Mukherjee S, Negi VS, Keitany G, Tanaka Y, Orth K:
In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax.
J Biol Chem
; 2008 May 30;283(22):15127-33
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[Title]
In vitro activation of the IkappaB kinase complex by
human
T-
cell leukemia
virus
type-1 Tax.
Human
T-
cell leukemia
virus
type-I expresses Tax, a 40-kDa oncoprotein that activates IkappaB kinase (IKK), resulting in constitutive activation of NFkappaB.
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.
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]
[Cites]
Cell. 2000 Oct 13;103(2):351-61
[
11057907.001
]
(PMID = 18223255.001).
[ISSN]
0021-9258
[Journal-full-title]
The Journal of biological chemistry
[ISO-abbreviation]
J. Biol. Chem.
[Language]
ENG
[Grant]
United States / NIAID NIH HHS / AI / R01 AI 056404; United States / NIDDK NIH HHS / DK / R21 DK 072134
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Bacterial Proteins; 0 / Gene Products, tax; 0 / HSP90 Heat-Shock Proteins; 0 / Multiprotein Complexes; 0 / NF-kappa B; 0 / Recombinant Proteins; 0 / YopP protein, Yersinia; EC 2.7.11.10 / I-kappa B Kinase; EC 3.1.3.16 / Phosphoprotein Phosphatases
[Other-IDs]
NLM/ PMC2397464
75.
Chiba K, Hashino S, Izumiyama K, Toyoshima N, Suzuki S, Kurosawa M, Asaka M:
Multiple osteolytic bone lesions with high serum levels of interleukin-6 and CCL chemokines in a patient with adult T cell leukemia.
Int J Lab Hematol
; 2009 Jun;31(3):368-71
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[Title]
Multiple osteolytic bone lesions with high serum levels of interleukin-6 and CCL chemokines in a patient with
adult T cell leukemia
.
A 37-year-old woman was diagnosed as having chronic
adult T
-
cell leukemia
(
ATL
) of the skin by a skin biopsy and
human
T-
cell leukemia
virus
type-1 serology at our hospital in August 1992.
The skin lesions of
ATL
were improved by treatment with psoralen ultraviolet ray A.
[MeSH-major]
Chemokines / blood. Interleukin-6 / blood.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ blood.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ complications. Osteolysis / blood. Osteolysis / etiology
[MeSH-minor]
Adult
. Chronic
Disease
. Fatal Outcome. Female. Humans
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(PMID = 18177436.001).
[ISSN]
1751-553X
[Journal-full-title]
International journal of laboratory hematology
[ISO-abbreviation]
Int J Lab Hematol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Chemokines; 0 / Interleukin-6
76.
Fan J, Ma G, Nosaka K, Tanabe J, Satou Y, Koito A, Wain-Hobson S, Vartanian JP, Matsuoka M:
APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo.
J Virol
; 2010 Jul;84(14):7278-87
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[Title]
APOBEC3G generates nonsense mutations in
human
T-
cell leukemia
virus
type 1 proviral genomes in vivo.
Human
T-
cell leukemia
virus
type 1 (
HTLV
-1) induces
cell
proliferation after infection, leading to efficient transmission by
cell
-to-
cell
contact.
After a long latent period, a fraction of carriers develop
adult T
-
cell leukemia
(
ATL
).
Genetic changes in the tax gene in
ATL
cells were reported in about 10% of
ATL
cases.
To determine genetic changes that may occur throughout the provirus, we determined the entire sequence of the
HTLV
-1 provirus in 60
ATL
cases.
Abortive genetic changes, including deletions, insertions, and nonsense mutations, were frequent in all viral genes except the HBZ gene, which is transcribed from the minus strand of the
virus
.
G-to-A base substitutions were the most frequent mutations in
ATL
cells.
The sequence context of G-to-A mutations was in accordance with the preferred target sequence of
human
APOBEC3G (hA3G).
The target sequences of hA3G were less frequent in the plus strand of the HBZ coding region than in other coding regions of the
HTLV
-1 provirus.
HTLV
-1-infected cells likely take advantage of hA3G to escape from the host immune system by losing expression of viral proteins.
[MeSH-major]
Cytidine Deaminase / metabolism. Genome, Viral.
HTLV
-I Infections / virology.
Human
T-
lymphotropic virus
1 / genetics.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ virology. Mutation. Proviruses / genetics
[MeSH-minor]
Base Sequence.
Cell
Line. Genes, Reporter. Genetic Variation. Genetic Vectors. Humans. Molecular Sequence Data. Mutagenesis
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(PMID = 20463074.001).
[ISSN]
1098-5514
[Journal-full-title]
Journal of virology
[ISO-abbreviation]
J. Virol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
EC 3.5.4.- / AICDA (activation-induced cytidine deaminase); EC 3.5.4.5 / APOBEC3G protein, human; EC 3.5.4.5 / Cytidine Deaminase
[Other-IDs]
NLM/ PMC2898234
77.
Mizobe T, Tsukada J, Higashi T, Mouri F, Matsuura A, Tanikawa R, Minami Y, Yoshida Y, Tanaka Y:
Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells.
Exp Hematol
; 2007 Dec;35(12):1812-22
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[Title]
Constitutive association of MyD88 to IRAK in
HTLV
-I-transformed T cells.
OBJECTIVE: Constitutive activation of nuclear factor (NF)-kappaB is a common feature of
human
T-
cell leukemia
virus
type I (
HTLV
-I)-transformed T cells.
Inhibition of NF-kappaB activity reduces
cell
growth and induces apoptosis of
HTLV
-I-transformed T cells, suggesting a central role of NF-kappaB in their proliferation and survival.
In this study, we investigated whether MyD88, an adaptor protein of Toll-like receptor (TLR) signaling, contributes to constitutive NF-kappaB activation in
HTLV
-I-transformed T cells.
MATERIALS AND METHODS: Activation status of MyD88 and interleukin (IL)-1R-
associated
kinase 1 (IRAK1) in
HTLV
-I-transformed
human
T cells, MT2, MT4, and HUT102 was examined by using Western blot and immunoprecipitation.
An expression vector encoding a dominant negative MyD88 with a deletion of its death domain (MyD88dn) was transfected into MT2 cells to evaluate roles of MyD88 in spontaneous activation of cytokine gene promoters and transcription factors, proliferation, and apoptosis in
HTLV
-I-transformed T cells.
RESULTS: Constitutive association of MyD88 with IRAK1 was observed in all three of
HTLV
-I-transformed T cells, but not in
HTLV
-I-negative T cells, such as Jurkat, HUT78, and MOLT4.
HTLV
-I Tax enhanced TLR expression and synergistically activated NF-kappaB with wild-type MyD88.
CONCLUSION: Our results show a novel pathway in NF-kappaB activation in
HTLV
-I-transformed T cells and further demonstrate a critical role of MyD88 in their dysregulated gene activation, survival, and proliferation.
[MeSH-major]
Human
T-
lymphotropic virus
1 / physiology. Interleukin-1 Receptor-
Associated
Kinases / metabolism. Myeloid Differentiation Factor 88 / metabolism
[MeSH-minor]
Base Sequence.
Cell
Line, Transformed.
Cell
Transformation, Viral. DNA Primers. Humans. Protein Binding. Reverse Transcriptase Polymerase Chain Reaction. T-Lymphocytes / metabolism
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 17920759.001).
[ISSN]
0301-472X
[Journal-full-title]
Experimental hematology
[ISO-abbreviation]
Exp. Hematol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / DNA Primers; 0 / MYD88 protein, human; 0 / Myeloid Differentiation Factor 88; EC 2.7.11.1 / Interleukin-1 Receptor-Associated Kinases
78.
Mustjoki S, Ekblom M, Arstila TP, Dybedal I, Epling-Burnette PK, Guilhot F, Hjorth-Hansen H, Höglund M, Kovanen P, Laurinolli T, Liesveld J, Paquette R, Pinilla-Ibarz J, Rauhala A, Shah N, Simonsson B, Sinisalo M, Steegmann JL, Stenke L, Porkka K:
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy.
Leukemia
; 2009 Aug;23(8):1398-405
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Clonality and immunophenotype were analyzed and related
clinical
information was collected.
Fifteen patients had a cytotoxic T-
cell
and seven patients had an NK-
cell
phenotype.
All T-
cell
expansions were clonal.
Responses to dasatinib were good and included complete, unexpectedly long-lasting remissions in patients with advanced
leukemia
.
In a phase II
clinical
study on 46 Philadelphia chromosome-
positive acute
lymphoblastic
leukemia
, patients with lymphocytosis had superior survival compared with patients without lymphocytosis.
By inhibiting immunoregulatory kinases, dasatinib may induce a reversible state of aberrant immune reactivity
associated
with good
clinical
responses and a distinct adverse effect profile.
[MeSH-major]
Antineoplastic Agents / pharmacology. Killer Cells, Natural / drug effects.
Leukemia
, Myelogenous, Chronic, BCR-ABL
Positive
/ drug therapy. Lymphocytosis / chemically induced. Precursor
Cell
Lymphoblastic
Leukemia
-
Lymphoma
/ drug therapy. Protein Kinase Inhibitors / pharmacology. Pyrimidines / pharmacology. T-Lymphocyte Subsets / drug effects. T-Lymphocytes, Cytotoxic / drug effects. Thiazoles / pharmacology
[MeSH-minor]
Adult
. Aged.
Clinical
Trials, Phase II as Topic / statistics & numerical data. Cohort Studies. Colitis / chemically induced. Dasatinib. Female. Humans. Immunophenotyping. Male. Middle Aged. Multicenter Studies as Topic. Neoplasm Proteins / antagonists & inhibitors. Pleurisy / chemically induced
MedlinePlus Health Information.
consumer health - Chronic Myeloid Leukemia
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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[CommentIn]
Acta Haematol. 2016;136(4):219-228
[
27656875.001
]
(PMID = 19295545.001).
[ISSN]
1476-5551
[Journal-full-title]
Leukemia
[ISO-abbreviation]
Leukemia
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Neoplasm Proteins; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 0 / Thiazoles; RBZ1571X5H / Dasatinib
79.
Okamura J, Uike N, Utsunomiya A, Tanosaki R:
Allogeneic stem cell transplantation for adult T-cell leukemia/lymphoma.
Int J Hematol
; 2007 Aug;86(2):118-25
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[Title]
Allogeneic stem
cell
transplantation for
adult T
-
cell leukemia
/
lymphoma
.
Adult T
-
cell leukemia
/
lymphoma
(
ATLL
) develops in elderly individuals who have been infected with
human
T-
cell leukemia
virus
type 1 (
HTLV
-1), and the prognosis for patients with
ATLL
has been extremely poor.
Retrospective studies of allogeneic stem
cell
transplantation (alloSCT) for selected populations of patients have achieved several encouraging results; however, the reported incidence of transplantation-related mortality (TRM) have been high, even though more than 80% of patients received stem cells from related donors and the patients were relatively young for
ATLL
.
This report documents a prospective feasibility study of alloSCT with reduced-intensity conditioning (RIST) for elderly
ATLL
patients (>50 years).
The
HTLV
-1 proviral load became undetectable in 8 of 15 patients, suggesting that RIST has potential as an antiviral treatment.
It is clear that a graft-versus-
ATLL
effect is present after alloSCT, regardless of the conditioning regimen or the stem
cell
source.
[MeSH-major]
Hematopoietic Stem
Cell
Transplantation / methods.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ therapy
Genetic Alliance.
consumer health - Transplantation
.
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author profiles
.
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Leukemia. 2005 May;19(5):829-34
[
15744352.001
]
(PMID = 17875524.001).
[ISSN]
0925-5710
[Journal-full-title]
International journal of hematology
[ISO-abbreviation]
Int. J. Hematol.
[Language]
eng
[Publication-type]
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
Japan
[Number-of-references]
19
80.
Shia AK, Gan GG, Jairaman S, Peh SC:
High frequency of germinal centre derivation in diffuse large B cell lymphoma from Asian patients.
J Clin Pathol
; 2005 Sep;58(9):962-7
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[Title]
High frequency of germinal centre derivation in diffuse large B
cell lymphoma
from Asian patients.
BACKGROUND: Recent reports have divided diffuse large B
cell lymphoma
(DLBCL) into germinal centre B
cell
-like and activated B
cell
-like subgroups with implicated differences in prognosis.
AIMS: To delineate the germinal centre B
cell
derivation group from an Asian series of DLBCLs.
Using the minimally acceptable criteria of t(14;18) rearrangement and/or CD10 expression, 26 of 54 cases were probably germinal centre
derived
, in agreement with other reports.
A higher proportion of cases had t(14;18) translocation, suggesting that they may be
derived
from transformed follicular
lymphomas
.
CONCLUSIONS: It may be possible to stratify patients for treatment using markers for specific lineages of B
cell
differentiation.
[MeSH-major]
Germinal Center / pathology.
Lymphoma
, B-
Cell
/ pathology.
Lymphoma
, Large B-
Cell
, Diffuse / pathology
[MeSH-minor]
Adolescent.
Adult
. Aged. Aged, 80 and over. Asian Continental Ancestry Group / genetics. Child. Chromosomes,
Human
, Pair 14 / genetics. Chromosomes,
Human
, Pair 18 / genetics. Female. Gene Rearrangement, B-Lymphocyte. Genes, bcl-2 / genetics. Humans. Immunophenotyping. Male. Middle Aged. Polymerase Chain Reaction / methods. Translocation, Genetic
Genetic Alliance.
consumer health - Large B cell diffuse lymphoma
.
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(PMID = 16126878.001).
[ISSN]
0021-9746
[Journal-full-title]
Journal of clinical pathology
[ISO-abbreviation]
J. Clin. Pathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC1770829
81.
Park CW, Kim A, Cha SW, Jung SH, Yang HW, Lee YJ, Lee HIe, Kim SH, Kim YH:
A case of phlegmonous gastritis associated with marked gastric distension.
Gut Liver
; 2010 Sep;4(3):415-8
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[Title]
A case of phlegmonous gastritis
associated
with marked gastric distension.
Phlegmonous gastritis is an
acute
and severe infectious
disease
that is occasionally fatal if the
diagnosis
is delayed.
Alcohol consumption, an immunocompromised state (e.g., due to HIV infection, rheumatoid arthritis, diabetes mellitus, or
adult T
-
cell lymphoma
), and mucosal injury of the stomach are reported to be predisposing factors.
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(PMID = 20981225.001).
[ISSN]
2005-1212
[Journal-full-title]
Gut and liver
[ISO-abbreviation]
Gut Liver
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Korea (South)
[Other-IDs]
NLM/ PMC2956360
[Keywords]
NOTNLM ; Gastric outlet obstruction / Phlegmonous gastritis
82.
Arisawa K, Soda M, Ono M, Uemura H, Hiyoshi M, Suyama A:
Trends of incidence rate of adult T-cell leukemia/lymphoma in an HTLV-1 endemic area in Japan.
Int J Cancer
; 2009 Aug 1;125(3):737-8
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[Title]
Trends of incidence rate of
adult T
-
cell leukemia
/
lymphoma
in an
HTLV
-1 endemic area in Japan.
[MeSH-major]
Endemic Diseases.
HTLV
-I Infections / epidemiology.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ epidemiology
[MeSH-minor]
Adult
. Age Distribution. Aged. Aged, 80 and over. Female. Humans. Incidence. Japan / epidemiology. Male. Middle Aged. Odds Ratio. Registries. Risk Assessment. Risk Factors. Time Factors
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(PMID = 19437534.001).
[ISSN]
1097-0215
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Comparative Study; Letter
[Publication-country]
United States
83.
Venkitaraman R, Sagar TG, George MK:
Adult T-cell lymphoma with HTLV-I and HTLV-II infection.
South Med J
; 2007 Nov;100(11):1178-9
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[Title]
Adult T
-
cell lymphoma
with
HTLV
-I and
HTLV
-II infection.
[MeSH-major]
HTLV
-I Infections /
diagnosis
.
HTLV
-II Infections /
diagnosis
.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/
diagnosis
.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ virology
[MeSH-minor]
Diagnosis
, Differential. Fatal Outcome. Humans. Male. Middle Aged
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(PMID = 17984755.001).
[ISSN]
0038-4348
[Journal-full-title]
Southern medical journal
[ISO-abbreviation]
South. Med. J.
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
United States
84.
Hensel M, Villalobos M, Kornacker M, Krasniqi F, Ho AD:
Pentostatin/cyclophosphamide with or without rituximab: an effective regimen for patients with Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma.
Clin Lymphoma Myeloma
; 2005 Sep;6(2):131-5
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[Title]
Pentostatin/cyclophosphamide with or without rituximab: an effective regimen for patients with Waldenstrom's macroglobulinemia/lymphoplasmacytic
lymphoma
.
BACKGROUND: Pentostatin has demonstrated significant activity as a single agent in patients with low-grade B-
cell
and T-
cell
lymphomas
and is less myelosuppressive than other purine analogues.
PATIENTS AND METHODS: We conducted a phase II trial with the combination regimen of PC-R (pentostatin/cyclophosphamide with or without rituximab) in 14 patients with Waldenstrom's macroglobulinemia (WM) and 3 patients with lymphoplasmacytic
lymphoma
(LL) without monoclonal serum immunoglobulin M (IgM), followed by a maintenance regimen with rituximab (375 mg/m2 every 3 months) for patients exhibiting a complete response (CR) or a partial response (PR) after 4-6 cycles.
No patients have had
disease
relapse to date, and all exhibited stable IgM serum levels.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / administration & dosage.
Leukemia
, Lymphocytic, Chronic, B-
Cell
/ drug therapy. Waldenstrom Macroglobulinemia / drug therapy
[MeSH-minor]
Adult
. Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Monoclonal, Murine-
Derived
. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / adverse effects. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects.
Disease
-Free Survival. Female. Humans. Immunoglobulin M / blood. Male. Middle Aged. Pentostatin / administration & dosage. Pentostatin / adverse effects. Remission Induction. Rituximab
Hazardous Substances Data Bank.
RITUXIMAB
.
Hazardous Substances Data Bank.
CYCLOPHOSPHAMIDE
.
Hazardous Substances Data Bank.
PENTOSTATIN
.
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(PMID = 16231851.001).
[ISSN]
1557-9190
[Journal-full-title]
Clinical lymphoma & myeloma
[ISO-abbreviation]
Clin Lymphoma Myeloma
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Immunoglobulin M; 395575MZO7 / Pentostatin; 4F4X42SYQ6 / Rituximab; 8N3DW7272P / Cyclophosphamide
85.
Bernasconi P, Calatroni S, Giardini I, Inzoli A, Castagnola C, Cavigliano PM, Rocca B, Boni M, Quarna J, Zappatore R, Caresana M, Bianchessi C, Pallavicini EB, Lazzarino M:
ABL1 amplification in T-cell acute lymphoblastic leukemia.
Cancer Genet Cytogenet
; 2005 Oct 15;162(2):146-50
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[Title]
ABL1 amplification in T-
cell
acute
lymphoblastic
leukemia
.
ABL1 amplification, due to a cryptic episomal translocation NUP214/ABL1, is a novel
finding
in T-
cell
acute
lymphoblastic
leukemia
(ALL).
Here we report on the incidence and
clinical
features of this genetic defect in a series of 30 consecutive
adult T
-
cell
ALL patients.
Multiple copies of the ABL1 gene were detected in two patients (6.6%), one with the karyotype 46,XY,t(1;3)(p36;p21),
del
(6)(q23)/46,XY and the other without analyzable metaphases.
(1) FISH is the only technique that promptly identifies T-
cell
ALL patients with ABL1 amplification, (2) quick identification with FISH is fundamental in the clinic because this T-
cell
ALL subset is imatinib sensitive but may become resistant due to development of additional mutations, and (3) ABL1 quantitative RT-PCR may be easily applied to monitor minimal residual
disease
.
[MeSH-major]
Genes, abl.
Leukemia
-
Lymphoma
,
Adult T
-
Cell
/ genetics
[MeSH-minor]
Aged. Child. Gene Amplification. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Male. Neoplasm, Residual /
diagnosis
. Neoplasm, Residual / genetics. Reverse Transcriptase Polymerase Chain Reaction
Genetic Alliance.
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NCI CPTAC Assay Portal.
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.
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(PMID = 16213363.001).
[ISSN]
0165-4608
[Journal-full-title]
Cancer genetics and cytogenetics
[ISO-abbreviation]
Cancer Genet. Cytogenet.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States