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1. Suárez Antelo J, Rodríguez García C, Montero Martínez C, Verea Hernando H: [Pulmonary Ewing sarcoma/primitive neuroectodermal tumor: a case report and a review of the literature]. Arch Bronconeumol; 2010 Jan;46(1):44-6
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  • [Title] [Pulmonary Ewing sarcoma/primitive neuroectodermal tumor: a case report and a review of the literature].
  • [Transliterated title] Sarcoma de Ewing pulmonar/tumor neuroectodérmico primitivo (PNET): aportación de un caso y revisión de la bibliografía.
  • The most common intrathoracic variants are synovial sarcoma, angiosarcoma, leiomyosarcoma, rhabdomyosarcoma, and sarcomatoid mesothelioma.
  • Although thoracic Ewing sarcoma/primitive neuroectodermal tumor (PNET) usually develops on the chest wall, there have been reports of primary Ewing sarcoma/PNET of the lung.
  • We present the case of a 22-year-old woman with Ewing sarcoma/PNET diagnosed following histologic, immunohistochemical, and in situ hybridization studies of a bronchial biopsy specimen.
  • [MeSH-major] Lung Neoplasms. Neuroectodermal Tumors, Primitive. Sarcoma, Ewing
  • [MeSH-minor] Female. Humans. Young Adult

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  • [Copyright] Copyright (c) 2009 SEPAR. Published by Elsevier Espana. All rights reserved.
  • (PMID = 19656607.001).
  • [ISSN] 1579-2129
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 13
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2. Atalar AC, Sungur M, Demirhan M, Ozger H: Neuropathic arthropathy of the shoulder associated with syringomyelia: a report of six cases. Acta Orthop Traumatol Turc; 2010;44(4):328-36
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  • Radiographs showed massive osteolysis of humeral head and glenoid process, and magnetic resonance imaging showed periarticular fluid collection, and degeneration at the rotator cuff and shoulder joint, resembling chronic septic arthritis or sarcoma.
  • Biopsy was performed in 4 patients before definitive diagnosis, and synovial hypertrophy and necrotic bone was found.
  • [MeSH-minor] Adult. Arthroplasty, Replacement. Combined Modality Therapy. Female. Humans. Humeral Head / pathology. Humeral Head / surgery. Hypesthesia / etiology. Hypesthesia / pathology. Hypesthesia / physiopathology. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Neurosurgical Procedures. Osteolysis, Essential / etiology. Osteolysis, Essential / pathology. Osteolysis, Essential / physiopathology. Range of Motion, Articular. Rotator Cuff / pathology. Rotator Cuff / surgery. Severity of Illness Index. Shoulder Joint / pathology. Shoulder Joint / surgery. Shoulder Pain / etiology. Shoulder Pain / pathology. Shoulder Pain / physiopathology. Treatment Outcome

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  • (PMID = 21252611.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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3. Hartel PH, Fanburg-Smith JC, Frazier AA, Galvin JR, Lichy JH, Shilo K, Franks TJ: Primary pulmonary and mediastinal synovial sarcoma: a clinicopathologic study of 60 cases and comparison with five prior series. Mod Pathol; 2007 Jul;20(7):760-9
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  • [Title] Primary pulmonary and mediastinal synovial sarcoma: a clinicopathologic study of 60 cases and comparison with five prior series.
  • Primary pulmonary and mediastinal synovial sarcoma is rare and poses a diagnostic challenge particularly when unusual histological features are present.
  • We present 60 cases of primary pulmonary and mediastinal synovial sarcoma (29 male and 27 female subjects; mean age, 42 years) and compare our results with five prior series to better define unusual histological features.
  • Clinically, patients with mediastinal synovial sarcoma were younger with a male gender bias.
  • In total, 92% (36/39) of primary pulmonary and mediastinal synovial sarcomas studied were positive for t(x;18).
  • In conclusion, our study confirms the clinical, histological, immunohistochemical, and molecular data from previous large series of primary pulmonary and mediastinal synovial sarcoma.
  • Compared with soft tissue synovial sarcoma, primary pulmonary and mediastinal synovial sarcoma has less calcification, less obvious mast cell influx, and less radiologic vascularity, but similar magnetic resonance imaging features, percentage of poorly differentiated tumors, and number of t(x;18)-positive tumors.
  • [MeSH-major] Lung Neoplasms / pathology. Mediastinal Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, CD56 / analysis. Calbindin 2. Cell Adhesion Molecules / analysis. Chromosomes, Human, Pair 18 / genetics. Chromosomes, Human, X / genetics. Female. Humans. Immunohistochemistry. Keratins / analysis. Male. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Proteins c-bcl-2 / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Survival Rate. Translocation, Genetic

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  • (PMID = 17464314.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD56; 0 / CALB2 protein, human; 0 / CD99 protein, human; 0 / Calbindin 2; 0 / Cell Adhesion Molecules; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / SYT-SSX fusion protein; 68238-35-7 / Keratins
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4. Mesiha M, Bauer T, Andrish J: Synovial sarcoma presenting as iliotibial band friction syndrome. J Knee Surg; 2009 Oct;22(4):376-8
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  • [Title] Synovial sarcoma presenting as iliotibial band friction syndrome.
  • However, synovial sarcoma is an elusive clinical entity that appears around many joints with variable presentations.
  • This case report is an example of a patient with a classic presentation of iliotibial band friction syndrome that was diagnosed as a synovial sarcoma on further investigation.
  • [MeSH-major] Knee Joint / pathology. Knee Joint / surgery. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / surgery
  • [MeSH-minor] Diagnosis, Differential. Fascia Lata / pathology. Female. Humans. Syndrome. Young Adult

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  • (PMID = 19902739.001).
  • [ISSN] 1538-8506
  • [Journal-full-title] The journal of knee surgery
  • [ISO-abbreviation] J Knee Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Chokesuwattanaskul W, Terrell J, Jenkins LA: Monophasic synovial sarcoma presenting as mitral valve obstruction. Tex Heart Inst J; 2010;37(4):472-5
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  • [Title] Monophasic synovial sarcoma presenting as mitral valve obstruction.
  • Pathologic evaluation confirmed the diagnosis of monophasic synovial sarcoma.To our knowledge, this is only the 3rd report of left atrial invasion and resultant mitral valve obstruction from a synovial sarcoma that infiltrated the pulmonary vein.
  • We believe that this is the 1st documented case of a metastatic left atrial synovial sarcoma in monophasic form.

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  • (PMID = 20844626.001).
  • [ISSN] 1526-6702
  • [Journal-full-title] Texas Heart Institute journal
  • [ISO-abbreviation] Tex Heart Inst J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2929870
  • [Keywords] NOTNLM ; Heart neoplasms/pathology/surgery / neoplasms/epidemiology / sarcoma, synovial/complications/diagnosis/genetics/pathology/radiotherapy/surgery/therapy/ultrasonography / thoracic neoplasms/surgery / tomography, X-ray computed / translocation, genetic/genetics
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6. Schwab JH, Healey JH, Athanasian EA: Wide en bloc extra-articular excision of the elbow for sarcoma with complex reconstruction. J Bone Joint Surg Br; 2008 Jan;90(1):78-83
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  • [Title] Wide en bloc extra-articular excision of the elbow for sarcoma with complex reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Elbow Joint / surgery. Reconstructive Surgical Procedures / methods. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Arthroplasty, Replacement. Bone Transplantation. Elbow / surgery. Female. Histiocytoma, Malignant Fibrous / surgery. Humans. Magnetic Resonance Imaging. Middle Aged. Recovery of Function. Retrospective Studies. Sarcoma, Ewing / surgery. Sarcoma, Synovial / surgery. Surgical Flaps

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  • (PMID = 18160504.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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7. Gavino AC, Spears MD, Peng Y: Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature. Int J Surg Pathol; 2010 Oct;18(5):394-7
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  • [Title] Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature.
  • A diagnosis of monophasic synovial sarcoma was favored initially.
  • Fluorescence in situ hybridization performed on the resection specimen showed no evidence of SYT gene rearrangement in the neoplastic cells, ruling out monophasic synovial sarcoma.
  • This case highlights the utility of skeletal muscle markers and cytogenetic testing in distinguishing SSRMS from its mimic, monophasic synovial sarcoma.
  • It is hoped that this case will expand the literature on adult SSRMS and help clinicians and pathologists better understand this newly described entity.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Diagnosis, Differential. Fatal Outcome. Female. Humans. Leg. MyoD Protein / metabolism. Myogenin / metabolism. Myosins / metabolism. Sarcoma, Synovial / diagnosis. Sclerosis

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  • (PMID = 19017660.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / Myogenin; EC 3.6.4.1 / Myosins
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8. Chew FS: Radiology of the hands: review and self-assessment module. AJR Am J Roentgenol; 2005 Jun;184(6 Suppl):S157-68
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  • CONCLUSION: The conditions illustrated in this article include erosive osteoarthritis, sarcoidosis, metastatic calcification, and synovial sarcoma.
  • [MeSH-minor] Adult. Aged. Bone Neoplasms / diagnosis. Bone Neoplasms / radiography. Calcinosis / diagnosis. Calcinosis / radiography. Education, Medical, Continuing. Female. Hand Deformities / diagnosis. Hand Deformities / radiography. Humans. Osteoarthritis / diagnosis. Osteoarthritis / radiography. Sarcoidosis / diagnosis. Sarcoidosis / radiography

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  • (PMID = 15908517.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. de Almeida-Lawall M, Mosqueda-Taylor A, Bologna-Molina RE, Domínguez-Malagón HR, Cano-Valdéz AM, Luna-Ortiz K, da Cunha IW: Synovial sarcoma of the tongue: case report and review of the literature. J Oral Maxillofac Surg; 2009 Apr;67(4):914-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma of the tongue: case report and review of the literature.
  • [MeSH-major] Sarcoma, Synovial / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Cell Nucleus / pathology. Cytoplasm / pathology. Diagnosis, Differential. Humans. Keratin-7 / analysis. Keratins / analysis. Male. Mucin-1 / analysis. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Proto-Oncogene Proteins c-bcl-2 / analysis. Translocation, Genetic / genetics. Vimentin / analysis

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  • (PMID = 19304058.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 43
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10. Chatzipantelis P, Kafiri G: Retroperitoneal synovial sarcoma: a clinicopathological study of 6 cases. J BUON; 2008 Apr-Jun;13(2):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal synovial sarcoma: a clinicopathological study of 6 cases.
  • PURPOSE: Synovial sarcoma (SS) arising in the retroperitoneum is a rare tumor.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Retroperitoneal Neoplasms / secondary. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Immunoenzyme Techniques. Male. Middle Aged. Prognosis. Survival Rate

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  • (PMID = 18555467.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Kijima Y, Yoshinaka H, Higashi M, Yokouchi M, Komiya S, Hisaoka M, Aikou T: Metastatic breast tumor arising from synovial sarcoma: report of a case. Surg Today; 2007;37(3):230-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic breast tumor arising from synovial sarcoma: report of a case.
  • We report a case of metastatic breast tumor arising from a synovial sarcoma of the lower limb.
  • A 27-year-old Japanese woman was diagnosed to have synovial sarcoma 14 months prior to finding a mass in her left breast.
  • An excisional biopsy was performed and a metastatic synovial sarcoma to the breast was confirmed.
  • To the best of our knowledge, this is only the second reported case of a solitary metastatic breast tumor arising from synovial sarcoma.
  • [MeSH-major] Breast Neoplasms / secondary. Knee. Neoplasm Recurrence, Local / therapy. Sarcoma, Synovial / secondary
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Lung Neoplasms / secondary. Mastectomy. Radiotherapy, Adjuvant

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  • (PMID = 17342363.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Cribb GL, Loo SC, Dickinson I: Limb salvage for soft-tissue sarcomas of the foot and ankle. J Bone Joint Surg Br; 2010 Mar;92(3):424-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We evaluated the oncological and functional outcome of 27 patients who had limb salvage for a soft-tissue sarcoma of the foot or ankle between 1992 and 2007, with a mean follow-up of 7.5 years (1.05 to 16.2).
  • Synovial sarcoma was the most frequent histological diagnosis.
  • Four patients have died of their sarcoma and two of other causes.
  • [MeSH-major] Ankle. Foot Diseases / therapy. Limb Salvage / methods. Sarcoma / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications. Reconstructive Surgical Procedures / methods. Recovery of Function. Surgical Flaps. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20190316.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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13. Atanackovic D, Luetkens T, Hildebrandt Y, Arfsten J, Bartels K, Horn C, Stahl T, Cao Y, Zander AR, Bokemeyer C, Kröger N: Longitudinal analysis and prognostic effect of cancer-testis antigen expression in multiple myeloma. Clin Cancer Res; 2009 Feb 15;15(4):1343-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Bone Marrow / pathology. Female. Humans. Immunotherapy. Longitudinal Studies. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 19190130.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MAGEA3 protein, human; 0 / MAGEC1 protein, human; 0 / MAGEC2 protein, human; 0 / Neoplasm Proteins; 0 / Repressor Proteins; 164289-47-8 / synovial sarcoma X breakpoint proteins
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14. Scheithauer BW, Silva AI, Kattner K, Seibly J, Oliveira AM, Kovacs K: Synovial sarcoma of the sellar region. Neuro Oncol; 2007 Oct;9(4):454-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma of the sellar region.
  • To date, no cases of primary synovial sarcoma have been described as occurring at this site.
  • We report an immunohistochemically and molecular genetically confirmed primary synovial sarcoma involving the sellar/parasellar region and cavernous sinus in an adult male.
  • [MeSH-major] Sarcoma, Synovial / pathology. Sarcoma, Synovial / therapy. Sella Turcica / pathology. Skull Base Neoplasms / pathology. Skull Base Neoplasms / therapy

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  • (PMID = 17704363.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
  • [Other-IDs] NLM/ PMC1994103
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15. Khademi B, Mohammadianpanah M, Ashraf MJ, Yeganeh F: Synovial sarcoma of the parapharyngeal space. Auris Nasus Larynx; 2007 Mar;34(1):125-9
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  • [Title] Synovial sarcoma of the parapharyngeal space.
  • Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space.
  • Pathologic report disclosed the diagnosis of synovial sarcoma.
  • [MeSH-major] Pharyngeal Neoplasms / radiotherapy. Pharyngeal Neoplasms / surgery. Sarcoma, Synovial / radiotherapy. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Radiotherapy Dosage

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  • (PMID = 17056221.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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16. Mankin HJ, Hornicek FJ: Diagnosis, classification, and management of soft tissue sarcomas. Cancer Control; 2005 Jan-Feb;12(1):5-21
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  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Fibrosarcoma / diagnosis. Fibrosarcoma / therapy. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / therapy. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / therapy. Liposarcoma / diagnosis. Liposarcoma / therapy. Male. Middle Aged. Neoplasm Staging / methods. Neurofibrosarcoma / diagnosis. Neurofibrosarcoma / therapy. Outcome Assessment (Health Care). Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / therapy. Sarcoma, Clear Cell / diagnosis. Sarcoma, Clear Cell / therapy. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / therapy. Survival Analysis

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  • (PMID = 15668648.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 205
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17. Cheung MC, Zhuge Y, Yang R, Ogilvie MP, Koniaris LG, Rodríguez MM, Sola JE: Incidence and outcomes of extremity soft-tissue sarcomas in children. J Surg Res; 2010 Oct;163(2):282-9
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  • Multivariate analysis identified RMS (HR 2.20, P < 0.001), nerve and muscle (not synovial sarcoma) tissue of origin (HR 2.26, P = 0.002, and HR 1.59, P = 0.036), regional or distant disease (HR 1.65, P = 0.011, and HR 5.96, P < 0.001, respectively), and lack of surgical intervention (HR 2.20, P < 0.001) as independent predictors of poor outcome.
  • [MeSH-major] Extremities. Sarcoma / epidemiology. Soft Tissue Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Incidence. Infant. Infant, Newborn. Male. Multivariate Analysis. Rhabdomyosarcoma / epidemiology. Rhabdomyosarcoma / mortality. SEER Program

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20638678.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Wang JG: Re: Primary cardiac synovial sarcoma. Interact Cardiovasc Thorac Surg; 2010 Oct;11(4):492
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  • [Title] Re: Primary cardiac synovial sarcoma.
  • [MeSH-major] Heart Neoplasms / therapy. Sarcoma, Synovial / therapy
  • [MeSH-minor] Adult. Humans. Male. Pericardium

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  • [CommentOn] Interact Cardiovasc Thorac Surg. 2010 Oct;11(4):490-2 [20603274.001]
  • (PMID = 20858657.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
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19. Naka N, Joyama S, Tsukamoto Y, Yoshioka K, Hashimoto N, Ujiiye T, Hayashi T, Kawase M, Mano M, Ishiguro S, Myoui A, Ueda T, Yoshikawa H, Araki N, Itoh K: Quantification of SSX mRNA expression in human bone and soft tissue tumors using nucleic acid sequence-based amplification. J Mol Diagn; 2005 May;7(2):187-97
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Animals. COS Cells. Child. Female. Gene Expression. Humans. Male. Middle Aged. RNA, Neoplasm / analysis. RNA, Neoplasm / metabolism

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  • (PMID = 15858142.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Repressor Proteins; 164289-47-8 / synovial sarcoma X breakpoint proteins
  • [Other-IDs] NLM/ PMC1867521
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20. Jung SC, Choi JA, Chung JH, Oh JH, Lee JW, Kang HS: Synovial sarcoma of primary bone origin: a rare case in a rare site with atypical features. Skeletal Radiol; 2007 Jan;36(1):67-71
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  • [Title] Synovial sarcoma of primary bone origin: a rare case in a rare site with atypical features.
  • Synovial sarcoma of bone origin is extremely rare and difficult to diagnose.
  • The lesion was confirmed as synovial sarcoma using a combination of histological and molecular genetic studies.
  • [MeSH-major] Bone Neoplasms / diagnostic imaging. Bone Neoplasms / pathology. Sarcoma, Synovial / diagnostic imaging. Sarcoma, Synovial / pathology. Tibia
  • [MeSH-minor] Female. Humans. Radiography. Young Adult

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  • (PMID = 16964492.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Olmos D, Postel-Vinay S, Molife LR, Okuno SH, Schuetze SM, Paccagnella ML, Batzel GN, Yin D, Pritchard-Jones K, Judson I, Worden FP, Gualberto A, Scurr M, de Bono JS, Haluska P: Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol; 2010 Feb;11(2):129-35
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  • [Title] Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study.
  • Preclinical data suggest a dependence on insulin-like growth-factor signalling for sarcoma subtypes, including Ewing's sarcoma, and early reports show antitumour activity of IGF-1R-targeting drugs in these diseases.
  • The first cohort (n=15) included patients with multiple sarcoma subtypes, age 18 years or older, and the second cohort (n=14) consisted of patients with refractory Ewing's sarcoma, age 9 years or older.
  • FINDINGS: 29 patients, 16 of whom had Ewing's sarcoma, were enrolled and received a total of 177 cycles of treatment (median 2, mean 6.1, range 1-24).
  • Pharmacokinetics were comparable between patients with sarcoma and those with other solid tumours.
  • 28 patients were assessed for response; two patients, both with Ewing's sarcoma, had objective responses (one complete response and one partial response) and eight patients had disease stabilisation (six with Ewing's sarcoma, one with synovial sarcoma, and one with fibrosarcoma) lasting 4 months or longer.
  • INTERPRETATION: Figitumumab is well tolerated and has antitumour activity in Ewing's sarcoma, warranting further investigation in this disease.
  • [MeSH-major] Antibodies, Monoclonal / pharmacokinetics. Antineoplastic Agents / pharmacokinetics. Sarcoma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Child. Cohort Studies. Female. Humans. Immunoglobulins, Intravenous. Male. Middle Aged. Receptor, IGF Type 1 / antagonists & inhibitors. Receptor, IGF Type 1 / immunology. Sarcoma, Ewing / drug therapy. Young Adult


22. Ashraf MJ, Azarpira N, Nowroozizadeh B, Shishegar M, Khademi B, Faramarzi A, Hashemi SB, Hakimzadeh A, Abedi E: Fine needle aspiration cytology of palatine tonsils: a study of 112 consecutive adult tonsillectomies. Cytopathology; 2010 Jun;21(3):170-5
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  • [Title] Fine needle aspiration cytology of palatine tonsils: a study of 112 consecutive adult tonsillectomies.
  • RESULTS: In this study, 106 cases were diagnosed as chronic tonsillitis/follicular hyperplasia, four cases as non-Hodgkin's lymphoma, one as Hodgkin's lymphoma and one as monophasic synovial sarcoma.
  • All malignant cases were diagnosed by FNAC, but synovial sarcoma was incorrectly diagnosed as squamous cell carcinoma.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Female. Hodgkin Disease / pathology. Humans. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Sarcoma, Synovial / pathology. Young Adult

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  • (PMID = 19291173.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Chung SD, Huang KH, Chueh SC, Lai MK, Lin WC: Primary synovial sarcoma of the kidney. J Formos Med Assoc; 2008 Apr;107(4):344-7
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  • [Title] Primary synovial sarcoma of the kidney.
  • Primary synovial sarcoma arising from the kidney is extremely rare.
  • We report two cases with primary renal synovial sarcoma.
  • Pathology of the two cases showed histologic and immunochemical features of synovial sarcoma with coexisting spindle and epithelial cells.
  • Physicians should be aware of the possibility of malignancy in cystic renal masses and that synovial sarcoma is one of the possibilities.

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  • (PMID = 18445550.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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24. Chang JM, Lee HJ, Lee SE, Byun SS, Choe GY, Kim SH, Seong CK, Kim SH: Pictorial review: Unusual tumours involving the prostate: radiological-pathological findings. Br J Radiol; 2008 Nov;81(971):907-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Carcinoid Tumor / diagnosis. Carcinoma, Small Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Transitional Cell / diagnosis. Cystadenocarcinoma, Mucinous / diagnosis. Cystadenoma / diagnosis. Histiocytoma, Malignant Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Leiomyosarcoma / diagnosis. Lymphoma / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Rhabdomyosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Tomography, X-Ray Computed. Ultrasonography, Interventional


25. Bahrami A, Folpe AL: Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am J Surg Pathol; 2010 Oct;34(10):1504-13
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  • [Title] Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period.
  • Adult-type fibrosarcoma (FS) was once considered the most common adult sarcoma, but is now considered a diagnosis of exclusion.
  • One hundred ninety-five cases diagnosed as adult FS in somatic soft tissue were retrieved from our institutional archives for the period 1960 to 2008.
  • Fluorescence in situ hybridization analysis for SYT gene rearrangement was done in 6 putative CK-negative synovial sarcomas (SS).
  • Non-FS (137 cases) were reclassified as: undifferentiated pleomorphic sarcoma (32 cases), SS (21 cases), solitary fibrous tumor (14 cases), myxofibrosarcoma (11 cases), malignant peripheral nerve sheath tumor (8 cases), FS dermatofibrosarcoma protuberans, and desmoplastic melanoma (4 cases each), low-grade fibromyxoid sarcoma, sarcomatoid carcinoma, desmoid-type fibromatosis, rhabdomyosarcoma, myofibroblastic sarcoma, spindle-cell liposarcoma (3 cases each), sclerosing epithelioid FS, fibroma-like epithelioid sarcoma, leiomyosarcoma, cellular fibrous histiocytoma (2 cases each), and others (17 cases).
  • Exclusive of undifferentiated pleomorphic sarcoma, the distinction of which from FS is subjective, 64% of putative FS were reclassified, most commonly as monophasic SS and solitary fibrous tumor.
  • We conclude that true FS is exceedingly rare, accounting for <1% of approximately 10,000 adult soft tissue sarcomas seen at our institution during this time period, and should be diagnosed with great caution.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Minnesota / epidemiology. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Repressor Proteins / genetics. Repressor Proteins / metabolism. Young Adult


26. Sun Y, Sun BC, Zhao XL, Wang J, Chen J, Li XQ, Feng YM, Fang ZW, Hao XS: [Roles of immunohistochemistry and detection of SYT-SSX fusion gene in diagnosis of synovial sarcoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Jul;36(7):480-4
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  • [Title] [Roles of immunohistochemistry and detection of SYT-SSX fusion gene in diagnosis of synovial sarcoma].
  • OBJECTIVE: To assess the diagnostic values of immunohistochemistry and SYT-SSX fusion gene detection for synovial sarcoma.
  • METHODS: Based on clinical features, histological and immunohistochemical profiles, 195 cases of tumors were divided into three diagnostic categories: definitive synovial sarcoma, probable synovial sarcoma and possible synovial sarcoma.
  • RESULTS: There were 62 (31.8%) definite synovial sarcomas, 49 (25.1%) probable synovial sarcomas and 84 cases (43.1%) possible synovial sarcomas.
  • SYT-SSX fusion gene was detected in 140 (78.2%) cases overall, including 94.7% (54/57) definite synovial sarcomas, 86.0% (37/43) probable synovial sarcomas and 62.0% (49/79) possible synovial sarcomas.
  • In tumors in the certain and probable synovial sarcoma categories, the positive rates of epithelial membrane antigen (EMA) were significantly higher in the SYT-SSX positive cases than SYT-SSX-negative cases (P = 0.022, P = 0.010, respectively).
  • In tumors of possible synovial sarcoma category, there were no significant differences of CK, EMA, vimentin or S-100 protein between SYT-SSX-positive and SYT-SSX-negative tumors.
  • EMA positivity has a similar diagnostic value to that of SYT-SSX by RT-PCR for tumors in the probable synovial sarcoma category.
  • However, detection of SYT-SSX is very important for diagnosis of the tumors in the category of possible synovial sarcoma.
  • [MeSH-major] Mucin-1 / metabolism. Oncogene Proteins, Fusion / metabolism. Sarcoma, Synovial / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction. S100 Proteins / metabolism. Vimentin / metabolism. Young Adult

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  • (PMID = 17845763.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Oncogene Proteins, Fusion; 0 / S100 Proteins; 0 / SYT-SSX fusion protein; 0 / Vimentin; 68238-35-7 / Keratins
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27. Singh R, Sharma AK, Magu NK, Kaur KP, Sen R, Magu S: Extraskeletal osteochondroma in the nape of the neck: a case report. J Orthop Surg (Hong Kong); 2006 Aug;14(2):192-5
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  • Differential diagnoses include myositis ossificans, a lipomatous lesion, a pseudomalignant osseous tumour, an ossifying fibromyxoid tumour, an extraskeletal chondroma with endochondral ossification, synovial (osteo) chondromatosis, tumoural calcinosis, a synovial sarcoma, and an extraskeletal osteosarcoma.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed


28. Dubovsky JA, McNeel DG: Inducible expression of a prostate cancer-testis antigen, SSX-2, following treatment with a DNA methylation inhibitor. Prostate; 2007 Dec 1;67(16):1781-90
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  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Neoplasm / blood. Antibody Specificity. Antigens, Neoplasm / immunology. Gene Expression Regulation, Neoplastic / drug effects. Humans. Immunoblotting. Immunoglobulin G / blood. Male. Membrane Proteins / immunology. Middle Aged. Neoplasms, Hormone-Dependent / genetics. Neoplasms, Hormone-Dependent / immunology. Neoplasms, Hormone-Dependent / therapy. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17929270.001).
  • [ISSN] 0270-4137
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K23 RR16489
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Antimetabolites, Antineoplastic; 0 / CTAG1B protein, human; 0 / Immunoglobulin G; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 164289-47-8 / synovial sarcoma X breakpoint proteins; 776B62CQ27 / decitabine; M801H13NRU / Azacitidine
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29. Ford ME, Stevens R, Rosado-de-Christenson ML, Hall NC, Suster S: Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. J Thorac Imaging; 2008 Aug;23(3):178-81
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  • [Title] Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma.
  • We report a case of rebound thymic hyperplasia manifesting as a hypermetabolic mass on fluorodeoxyglucose positron emission tomography-computed tomography after pneumonectomy and chemotherapy for primary pulmonary synovial sarcoma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Pneumonectomy. Sarcoma, Synovial / drug therapy. Sarcoma, Synovial / surgery. Thymus Hyperplasia / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Doxorubicin / therapeutic use. Humans. Ifosfamide / therapeutic use. Male. Neoplasm Recurrence, Local / complications. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Positron-Emission Tomography. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18728544.001).
  • [ISSN] 1536-0237
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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30. Flannery T, Kano H, Niranjan A, Monaco EA 3rd, Flickinger JC, Kofler J, Lunsford LD, Kondziolka D: Gamma knife radiosurgery as a therapeutic strategy for intracranial sarcomatous metastases. Int J Radiat Oncol Biol Phys; 2010 Feb 1;76(2):513-9
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  • The primary pathology was metastatic leiomyosarcoma (4 patients), osteosarcoma (3 patients), soft-tissue sarcoma (5 patients), chondrosarcoma (2 patients), alveolar soft part sarcoma (2 patients), and rhabdomyosarcoma, Ewing's sarcoma, liposarcoma, neurofibrosarcoma, and synovial sarcoma (1 patient each).
  • [MeSH-major] Brain Neoplasms / surgery. Radiosurgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Survival Rate. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19467792.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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31. Just PA, Tissier F, Silvera S, Dousset B, Ballet S, Delattre O, Vacher-Lavenu MC, Goldwasser F, Bertagna X, De Pinieux G: Unexpected diagnosis for an adrenal tumor: synovial sarcoma. Ann Diagn Pathol; 2010 Feb;14(1):56-9
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  • [Title] Unexpected diagnosis for an adrenal tumor: synovial sarcoma.
  • The diagnosis of primitive synovial sarcoma of the left adrenal fossa was confirmed by the presence of the characteristic t(X;18) translocation.
  • To our knowledge, this report constitutes the first described case of synovial sarcoma arising in the adrenal gland.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Magnetic Resonance Imaging. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Biopsy. Fatal Outcome. Female. Humans. Immunohistochemistry

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  • [Copyright] 2010. Published by Elsevier Inc.
  • (PMID = 20123459.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Herbst RS, Eckhardt SG, Kurzrock R, Ebbinghaus S, O'Dwyer PJ, Gordon MS, Novotny W, Goldwasser MA, Tohnya TM, Lum BL, Ashkenazi A, Jubb AM, Mendelson DS: Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol; 2010 Jun 10;28(17):2839-46
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  • Two patients with sarcoma (synovial and undifferentiated) experienced serious AEs associated with rapid tumor necrosis.
  • [MeSH-minor] Adult. Aged. Cohort Studies. Dose-Response Relationship, Drug. Female. Humans. Male. Maximum Tolerated Dose. Middle Aged. Recombinant Proteins / administration & dosage. Recombinant Proteins / adverse effects. Recombinant Proteins / pharmacokinetics

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  • (PMID = 20458040.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Recombinant Proteins; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFSF10 protein, human
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33. Wu LQ, Lu Y, Wang XF, Lv ZH, Zhang B, Yang JY: Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma. Life Sci; 2006 Jul 17;79(8):744-8
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  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Neoplasm / analysis. Antigens, Neoplasm / blood. Antigens, Neoplasm / genetics. Biomarkers, Tumor / blood. Case-Control Studies. Female. Gene Expression Regulation, Neoplastic. Humans. Leukocytes, Mononuclear / chemistry. Male. Middle Aged. RNA, Messenger / analysis. RNA, Messenger / genetics

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  • (PMID = 16546222.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 164289-47-8 / synovial sarcoma X breakpoint proteins
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34. Ayyoub M, Merlo A, Hesdorffer CS, Rimoldi D, Speiser D, Cerottini JC, Chen YT, Old LJ, Stevanovic S, Valmori D: CD4+ T cell responses to SSX-4 in melanoma patients. J Immunol; 2005 Apr 15;174(8):5092-9
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  • Genes of the synovial sarcoma X breakpoint (SSX) family are expressed in different human tumors, including melanomas, but not in adult somatic tissues.
  • [MeSH-minor] Adult. Alleles. Amino Acid Sequence. Cell Line, Tumor. Epitope Mapping. Epitopes / chemistry. Epitopes / genetics. Genes, MHC Class II. Histocompatibility Antigens Class II / metabolism. Humans. In Vitro Techniques. Molecular Sequence Data. Protein Structure, Tertiary

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  • (PMID = 15814740.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Epitopes; 0 / Histocompatibility Antigens Class II; 0 / Neoplasm Proteins; 0 / Repressor Proteins; 164289-47-8 / synovial sarcoma X breakpoint proteins
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35. Alyas F, Lee J, Ahmed M, Connell D, Saifuddin A: Prevalence and diagnostic significance of fluid-fluid levels in soft-tissue neoplasms. Clin Radiol; 2007 Aug;62(8):769-74; discussion 775
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  • One of the 24 (4.1%) was non-neoplastic (one ganglion), 12 (50.0%) were benign neoplasms (nine haemangiomas, two schwannomas, one hamartoma) and 11 (45.9%) were malignant neoplasms (one leiomyosarcoma, one liposarcoma, one malignant fibrous histocytoma, one mxyofibrosarcoma, two primitive neuroectodermal tumours, two synovial sarcomas, one spindle cell sarcoma, and two sarcomas not otherwise specified).
  • [MeSH-minor] Adult. Biopsy. Exudates and Transudates. Female. Humans. Image Enhancement. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies

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  • [CommentIn] Clin Radiol. 2008 May;63(5):610; author reply 610 [18374727.001]
  • (PMID = 17604765.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Jedlicka V, Dolezel J, Vlcek P, Pestál A, Veselý K, Bednarík O, Capov I: [Multiple lung metastasectomy for the poor differentiated metastatic synovial sarcoma]. Rozhl Chir; 2007 Feb;86(2):85-8
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  • [Title] [Multiple lung metastasectomy for the poor differentiated metastatic synovial sarcoma].
  • OBJECTIVES: Synovial sarcoma is the rare indication for the pulmonary metastasectomy due to its aggressive biologic behavior and early dissemination.
  • METHODS: From the group of 7 patients with the lung metastases of the synovial sarcoma operated in our department during the last 5 years we are presenting the case of the 39 years old man with the previous history of the surgical removal of the synovial sarcoma near the cubital fossa one year before.
  • Analysis of the pathologist showed biphasic metastatic synovial sarcoma with the high mitotic activity.
  • CONCLUSION: Lung metastasectomy of the multiple lung metastases of the synovial sarcoma is of value despite of uncertain long-term prognosis.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Sarcoma, Synovial / secondary. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Pneumonectomy. Survival Rate

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  • (PMID = 17436672.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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37. Gong YL, Li T, Guo H, Sun Y, Chi YK, Ling Y, Shen Q, Liu HJ, Hou L, Zhang B: [Expression of TEIF protein in soft tissue tumors and its significance]. Zhonghua Bing Li Xue Za Zhi; 2006 Nov;35(11):651-5
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  • The positive staining was predominantly in synovial sarcoma 94% (16/17), primitive neuroectodermal tumor (PNET) 91% (21/23), both of which were significantly higher than 43% (6/14) of dermatofibrosarcoma protuberans, 38% (6/16) of myxofibrosarcoma, 36% (8/22) of malignant peripheral nerve sheath tumor, 32% (6/19) of liposarcoma, (P < 0.05, respectively), but not higher than 75% (15/20) of malignant fibrous histiocytoma, 70% (7/10) of rhabdomyosarcoma or 64% (9/14) of leiomyosarcoma.
  • Meanwhile, strong positive staining of TEIF (>or= 2+) was frequently observed in PNET (83%, 19/23) and synovial sarcoma (76%, 13/17).
  • With respect to FNCLCC grading, 19 cases of grade I sarcoma TEIF was 32% (6/19) and strong positive was 11% (2/19), 44 cases of grade II sarcoma was 48% (21/44) and 32% (14/44), and 70 of grade III was 84% (59/70) and 70% (49/70).
  • The rate of either positive or strong positive in grade III sarcoma was significantly different from that of either grade I or II (P < 0.05), but no difference between the latter two groups (P > 0.05).
  • CONCLUSIONS: TEIF protein could be detected in large part of soft tissue sarcomas, and it not only over-expressed in most of PNET, synovial sarcomas, but also correlated with histological grading.
  • [MeSH-major] Sarcoma / metabolism. Soft Tissue Neoplasms / metabolism. Transcription Factors / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Blotting, Western. Cell Line, Tumor. Child. Child, Preschool. Female. HeLa Cells. Histiocytoma, Malignant Fibrous / metabolism. Histiocytoma, Malignant Fibrous / pathology. Humans. Immunohistochemistry. Infant. Leiomyoma / metabolism. Leiomyoma / pathology. Male. Middle Aged. Neuroectodermal Tumors, Primitive / metabolism. Neuroectodermal Tumors, Primitive / pathology. Rhabdomyosarcoma / metabolism. Rhabdomyosarcoma / pathology. Sarcoma, Synovial / metabolism. Sarcoma, Synovial / pathology. Tissue Array Analysis. Young Adult

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  • (PMID = 17374207.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Transcription Factors; EC 2.7.1.- / SCYL1 protein, human
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38. Stejskalová E, Jarosová M, Malis J, Sumerauer D, Urbánková H, Krsková L, Pýcha K, Schovanec J, Balcárková J, Smelhaus V, Kodetová D, Starý J: [Clinical relevance of chromosomal aberrations in bone and soft tissue tumors in children and young adults]. Klin Onkol; 2009;22(2):58-66
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  • PATIENTS ANDMETHODS: We analyzed a cohort of 26 patients with Ewing sarcoma/PNET, 15 patients with rhabdomyosarcoma, 5 with synovial sarcoma and one patient with an undifferentiated sarcoma using the cytogenetic and molecular cytogenetic techniques M-FISH and arrayCGH.
  • Four patients with synovial sarcoma had the diagnostic t(X;18)(p11.2;q11.2), one of them had a complex karyotype with a complex t(X;18;21) (p11.2;q11.2;q11.2) together with t(2;5)(q24-32;p13-14) and t(12;20)(p11;q13).
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Comparative Genomic Hybridization. Female. Humans. In Situ Hybridization, Fluorescence. Male. Young Adult

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  • (PMID = 19522375.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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39. Sato S, Hosaka Y, Togashi K: [Primary pulmonary synovial sarcoma confirmed by gene expression analysis]. Kyobu Geka; 2010 Jun;63(6):459-61
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  • [Title] [Primary pulmonary synovial sarcoma confirmed by gene expression analysis].
  • We report a patient who was diagnosed with synovial sarcoma based on gene expression analysis.
  • Pathological examination showed a mesenchymal tumor consisting of short-spindle, small, round cells, and the differentiation between synovial sarcoma and peripheral neuroectodermal tumor was necessary.
  • RT-PCR to examine the gene expression of cells revealed a SYT-SSX fusion gene, and a diagnosis of primary synovial sarcoma of the lung was made.
  • [MeSH-major] Lung Neoplasms / genetics. Oncogene Proteins, Fusion / analysis. Sarcoma, Synovial / genetics
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20533736.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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40. Ryś J, Kruczak A, Marczyk E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S: Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol; 2009;60(2):98-104; quiz 105
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  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Osteosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Treatment Outcome. Young Adult

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  • (PMID = 19886185.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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41. Zou BH, Zhang L: [Primary pulmonary sarcoma-a study of 8 cases]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2010 Apr;32(2):171-3
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  • [Title] [Primary pulmonary sarcoma-a study of 8 cases].
  • OBJECTIVE: To summarize the diagnosis, pathology, treatment and prognosis of 8 cases of primary pulmonary sarcoma.
  • METHOD: The clinical data of 8 patients with primary pulmonary sarcoma in the PUMC Hospital from 1986 to 2009 were retrospectively analyzed.
  • The pathological diagnoses included leiomyosarcoma (n=1), synovial sarcoma (n=1), malignant fibrous histiocytoma (n=1), and unknown tumors due to poor differentiation (n=5).
  • CONCLUSIONS: The primary pulmonary sarcoma is a rare disease with non-specific clinical manifestations.
  • [MeSH-major] Lung Neoplasms. Sarcoma
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20450547.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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42. Lu Y, Wu LQ, Lü ZH, Wang XJ, Yang JY: Expression of SSX-1 and NY-ESO-1 mRNA in tumor tissues and its corresponding peripheral blood expression in patients with hepatocellular carcinoma. Chin Med J (Engl); 2007 Jun 20;120(12):1042-6
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  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Neoplastic Cells, Circulating. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17637219.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 164289-47-8 / synovial sarcoma X breakpoint proteins
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43. Karplus G, Krasin MJ, Rodriguez-Galindo C, McCarville B, Jenkins J, Rao B, Spyridis G, Spunt SL: Retrospective study of the surgical management and outcome of nonrhabdomyosarcoma soft tissue sarcomas of the groin and axilla in children. J Pediatr Surg; 2009 Oct;44(10):1972-6
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  • RESULTS: Of the 300 patients treated for NRSTSs, only 10 had tumors of the axilla or groin (6 of whom had synovial sarcoma).
  • [MeSH-major] Axilla / surgery. Groin / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Cause of Death. Child. Female. Humans. Longitudinal Studies. Male. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Retrospective Studies. Rhabdomyosarcoma / surgery. Risk Factors. Sarcoma, Synovial / surgery. Soft Tissue Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19853757.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS502476; NLM/ PMC3748624
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44. Boniver V, Moreau P, Lefebvre P: Synovial sarcoma of the larynx: case report and literature review. B-ENT; 2005;1(1):47-51
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  • [Title] Synovial sarcoma of the larynx: case report and literature review.
  • Synovial sarcoma is a rare mesenchymal malignancy which represents 8.5% of all soft tissue sarcomas and usually occurs in the lower extremities of young adults.
  • We present here a case of aryepiglottic synovial sarcoma.
  • [MeSH-major] Laryngeal Neoplasms / epidemiology. Sarcoma, Synovial / epidemiology
  • [MeSH-minor] Adult. Endoscopy. Female. Humans. Laser Therapy

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  • (PMID = 15999676.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 19
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45. Uslu M, Cetik O, Atasoy P, Eksioglu F, Engin M: Localized pigmented villonodular synovitis of the knee: acute onset in pregnancy. Rheumatol Int; 2006 Sep;26(11):1054-6
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  • Arthroscopy demonstrated a local synovial tumor and excision was performed with arthrotomy.
  • [MeSH-minor] Adult. Arthroscopy. Female. Humans. Pregnancy. Sarcoma, Synovial / pathology. Sarcoma, Synovial / surgery


46. Spark JI, Charalabidis P, Laws P, Seben R, Clayer M: Vascular reconstruction in lower limb musculoskeletal tumours. ANZ J Surg; 2009 Sep;79(9):619-23
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  • Four patients had a leiomyosarcoma, and one each of osteosarcoma, synovial chondrosarcoma, synovial sarcoma, liposarcoma and recurrent malignant peripheral nerve sheath tumour.
  • One patient with synovial chondrosarcoma developed a local recurrence and underwent an above-knee amputation.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Limb Salvage. Male. Middle Aged. Saphenous Vein / transplantation. Young Adult

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  • (PMID = 19895517.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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47. Xu J, Sun H, Xiao Y: [Application of medial head gastrocnemius muscle flap to limb-salvage operation of proximal tibial malignant tumor]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Apr;21(4):352-5
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  • Among them, there were 4 patients with osteosarcoma, 6 with malignant fibrous histocytoma, 1 with malignant giant cell tumor, 1 with synovial sarcoma, and 1 with Ewing's sarcoma.
  • The patient with Ewing's sarcoma had a local tumor recurrence 18 months after operation; though treated with the focal cleaning and the bone cement filling, the patient still developed lung metastasis of the tumor 26 months after operation.
  • [MeSH-minor] Adolescent. Adult. Arthroplasty, Replacement, Knee. Bone Transplantation / methods. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome. Young Adult

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  • (PMID = 17546876.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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48. Li J, Li YY, Teng XD, Xu LM: [Clinicopathologic analysis of primary synovial sarcoma of prostate]. Zhonghua Bing Li Xue Za Zhi; 2009 Jul;38(7):479-80
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  • [Title] [Clinicopathologic analysis of primary synovial sarcoma of prostate].
  • [MeSH-major] Prostatic Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Combined Modality Therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Keratins / metabolism. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Prostate-Specific Antigen / metabolism. Prostatectomy. Vimentin / metabolism

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  • (PMID = 19781197.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Vimentin; 68238-35-7 / Keratins; EC 3.4.21.77 / Prostate-Specific Antigen
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49. Li EX, Zhang YT, Shang JT, Xu Z, Geng Y, Li SM, Shi F, Wu YY: [Effect of modified MAID regimen for patients with advanced soft tissue sarcoma]. Ai Zheng; 2006 Aug;25(8):1048-51
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  • [Title] [Effect of modified MAID regimen for patients with advanced soft tissue sarcoma].
  • BACKGROUND & OBJECTIVES: Clinical study suggests that 72-hour continuous infusion (CIV) of MAID regimen is more effective and achieves longer time of no progression than ADR-based two-drug regimen in advanced soft tissue sarcoma (ASTS) treatment, but has no improvement on the long-term survival.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fibrosarcoma / drug therapy. Rhabdomyosarcoma / drug therapy. Sarcoma, Synovial / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Dacarbazine / administration & dosage. Doxorubicin / administration & dosage. Doxorubicin / analogs & derivatives. Female. Follow-Up Studies. Humans. Ifosfamide / administration & dosage. Infusions, Intravenous. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Middle Aged. Nausea / chemically induced. Neoplasm Staging. Neutropenia / chemically induced. Remission Induction. Survival Rate. Thrombocytopenia / chemically induced. Young Adult

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  • (PMID = 16965692.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; D58G680W0G / pirarubicin; UM20QQM95Y / Ifosfamide
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50. Sakellariou VI, Mavrogenis AF, Papagelopoulos PJ: Limb salvage surgery using the intramedullary diaphyseal segmental defect fixation system. J Long Term Eff Med Implants; 2008;18(1):59-67
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  • Histological diagnosis included adamantinoma, synovial sarcoma, multiple myeloma, metastatic renal cell carcinoma, myeloid carcinoma of the thyroid gland, and adenocarcinoma of the stomach.
  • [MeSH-minor] Adult. Aged. Diaphyses / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prosthesis Design. Prosthesis Failure. Reoperation. Treatment Outcome. Wound Healing

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  • (PMID = 19348612.001).
  • [ISSN] 1050-6934
  • [Journal-full-title] Journal of long-term effects of medical implants
  • [ISO-abbreviation] J Long Term Eff Med Implants
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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51. Sugawara S, Ehara S, Hitachi S, Okada K: Patterns of soft-tissue tumor extension in and out of the pelvis. AJR Am J Roentgenol; 2010 Mar;194(3):746-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Myositis Ossificans / diagnosis. Myositis Ossificans / pathology. Neoplasm Invasiveness. Neoplasms, Adipose Tissue / diagnosis. Neoplasms, Adipose Tissue / pathology. Neoplasms, Fibrous Tissue / diagnosis. Neoplasms, Fibrous Tissue / pathology. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / pathology. Neurofibromatoses / diagnosis. Neurofibromatoses / pathology. Pelvic Bones / anatomy & histology. Pelvic Bones / pathology. Retrospective Studies. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 20173154.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Lubieniecka JM, Nielsen TO: cDNA microarray-based translational research in soft tissue sarcoma. J Surg Oncol; 2005 Dec 15;92(4):267-71
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  • [Title] cDNA microarray-based translational research in soft tissue sarcoma.
  • The authors discuss application of cDNA microarray technology in translational research to identify diagnostic markers and therapeutic targets in adult soft tissue sarcoma.
  • Recent results in synovial sarcoma are used to highlight the applicability of this technology for marker and target discovery, as well as the need for preclinical validation of putative therapeutic targets.
  • [MeSH-major] Gene Expression Profiling. Oligonucleotide Array Sequence Analysis. Sarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Gastrointestinal Stromal Tumors / genetics. Humans. Molecular Diagnostic Techniques. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / genetics

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 16299802.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Editorial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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53. Guadagnolo BA, Zagars GK, Ballo MT, Patel SR, Lewis VO, Pisters PW, Benjamin RS, Pollock RE: Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy. Int J Radiat Oncol Biol Phys; 2007 Nov 15;69(4):1173-80
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  • [Title] Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy.
  • PURPOSE: To evaluate prognostic factors and treatment outcomes in patients with localized synovial sarcoma treated with conservation surgery and radiotherapy (RT).
  • METHODS AND MATERIALS: Between 1960 and 2003, 150 patients with nonmetastatic synovial sarcoma were treated with conservation surgery and RT.
  • CONCLUSIONS: Synovial sarcoma is adequately controlled at the primary site by conservation surgery and RT.
  • [MeSH-major] Sarcoma, Synovial / radiotherapy. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Regression Analysis. Retrospective Studies. Survival Rate. Treatment Outcome. Tumor Burden

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  • (PMID = 17689031.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Arnold PM, Roh S, Ha TM, Anderson KK: Metastatic synovial sarcoma with cervical spinal cord compression treated with posterior ventral resection: case report. J Spinal Cord Med; 2010;33(1):80-4
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  • [Title] Metastatic synovial sarcoma with cervical spinal cord compression treated with posterior ventral resection: case report.
  • CONTEXT: Synovial sarcomas, which represent 5% to 10% of all adult soft-tissue sarcomas, usually metastasize to the lungs.
  • FINDINGS: A 26-year-old woman presented with neck pain, arm weakness, and a history of metastatic synovial sarcoma originating at the right knee.
  • CONCLUSION AND CLINICAL RELEVANCE: Metastatic spinal cord compression from synovial sarcoma is rare.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Sarcoma, Synovial / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 20397449.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853335
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55. Krsková L, Kalinová M, Brizová H, Mrhalová M, Sumerauer D, Kodet R: Molecular and immunohistochemical analysis of ERBB2 expression in correlation with proliferation rate in synovial sarcoma. Diagn Mol Pathol; 2007 Dec;16(4):211-7
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  • [Title] Molecular and immunohistochemical analysis of ERBB2 expression in correlation with proliferation rate in synovial sarcoma.
  • The aim of the study was to determine whether or not the tyrosine kinase receptor ERBB2 is overexpressed in synovial sarcomas (SSs).
  • [MeSH-major] RNA, Messenger / analysis. Receptor, ErbB-2 / analysis. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Cell Proliferation. Child. Child, Preschool. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Ki-67 Antigen / analysis. Ki-67 Antigen / genetics. Ki-67 Antigen / metabolism. Male. Middle Aged

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  • (PMID = 18043284.001).
  • [ISSN] 1052-9551
  • [Journal-full-title] Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • [ISO-abbreviation] Diagn. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / RNA, Messenger; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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56. ten Heuvel SE, Hoekstra HJ, Bastiaannet E, Suurmeijer AJ: The classic prognostic factors tumor stage, tumor size, and tumor grade are the strongest predictors of outcome in synovial sarcoma: no role for SSX fusion type or ezrin expression. Appl Immunohistochem Mol Morphol; 2009 May;17(3):189-95
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  • [Title] The classic prognostic factors tumor stage, tumor size, and tumor grade are the strongest predictors of outcome in synovial sarcoma: no role for SSX fusion type or ezrin expression.
  • BACKGROUND: The aim of this study was to investigate prognostic factors influencing the survival of synovial sarcoma, including the debated role of SYT-SSX fusion type and the newly suggested immunohistochemical marker ezrin.
  • PATIENTS AND METHODS: From 1984 to 2005, 45 patients-25 men (56%) and 20 women (44%) with a median age of 31 (range: 2 to 81) years-were diagnosed with a synovial sarcoma.
  • Ezrin showed high expression in glandular and nonglandular epithelioid components in biphasic synovial sarcoma.
  • Variable expression was found in the mesenchymal component of monophasic and biphasic synovial sarcoma.
  • Low versus high ezrin expression levels in monophasic and/or biphasic synovial sarcoma did not correlate with patient outcome.
  • CONCLUSIONS: Disease stage at presentation, tumor size, and tumor grade were significant predictors of survival in synovial sarcoma.

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  • (PMID = 18997619.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein; 0 / ezrin
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57. Pazzaglia L, Benassi MS, Ragazzini P, Gamberi G, Ponticelli F, Chiechi A, Hattinger CM, Morandi L, Alberghini M, Zanella L, Picci P, Mercuri M: Molecular alterations of monophasic synovial sarcoma: loss of chromosome 3p does not alter RASSF1 and MLH1 transcriptional activity. Histol Histopathol; 2006 02;21(2):187-95
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  • [Title] Molecular alterations of monophasic synovial sarcoma: loss of chromosome 3p does not alter RASSF1 and MLH1 transcriptional activity.
  • Differential diagnosis of monophasic synovial sarcoma requires the detection of specific biological markers.
  • In this study we evaluated the presence of molecular alterations in 15 monophasic synovial sarcomas.
  • These findings confirm the genetic complexity of monophasic synovial sarcoma and underline the need to integrate different analyses for a better knowledge of this tumour, essential to investigate new diagnostic and prognostic markers.
  • [MeSH-major] Carrier Proteins / genetics. Chromosome Deletion. Chromosomes, Human, Pair 3 / genetics. Neoplasms, Connective Tissue / genetics. Nuclear Proteins / genetics. Sarcoma, Synovial / genetics. Transcription, Genetic. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adult. Aged. Biomarkers, Tumor. DNA, Neoplasm / analysis. DNA, Neoplasm / genetics. Down-Regulation. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Keratins / analysis. Keratins / genetics. Male. Microsatellite Repeats. Middle Aged. Mucin-1 / analysis. Mucin-1 / genetics. MutL Protein Homolog 1. Oligonucleotide Array Sequence Analysis. Prognosis. RNA, Messenger / analysis. Vimentin / analysis. Vimentin / genetics

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  • (PMID = 16329043.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Mucin-1; 0 / Nuclear Proteins; 0 / RASSF1 protein, human; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins; 0 / Vimentin; 68238-35-7 / Keratins; EC 3.6.1.3 / MutL Protein Homolog 1
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58. Shaariyah MM, Mazita A, Masaany M, Razif MY, Isa MR, Asma A: Synovial sarcoma: a rare presentation of parapharyngeal mass. Chin J Cancer; 2010 Jun;29(6):631-3
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  • [Title] Synovial sarcoma: a rare presentation of parapharyngeal mass.
  • Synovial sarcoma is a rare soft tissue sarcoma of the head and neck region involving the parapharyngeal space.
  • The diagnosis of synovial sarcoma can be very challenging to the pathologists.
  • We present a rare case of parapharyngeal synovial sarcoma in a young female patient who had a two-month history of left cervical intumescent mass at level II.
  • Transcervical excision of the mass was performed and the first case of parapharyngeal sarcoma was identified in our center by fluorescence in situ hybridization (FISH) technique.
  • [MeSH-major] Pharyngeal Neoplasms / diagnosis. Pharyngeal Neoplasms / surgery. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Combined Modality Therapy. Female. Humans. In Situ Hybridization, Fluorescence. Neoplasm, Residual. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 20507738.001).
  • [ISSN] 1000-467X
  • [Journal-full-title] Chinese journal of cancer
  • [ISO-abbreviation] Chin J Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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59. Mitsuhashi A, Nagai Y, Suzuka K, Yamazawa K, Nojima T, Nikaido T, Ishikura H, Matsui H, Shozu M: Primary synovial sarcoma in fallopian tube: case report and literature review. Int J Gynecol Pathol; 2007 Jan;26(1):34-7
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  • [Title] Primary synovial sarcoma in fallopian tube: case report and literature review.
  • Synovial sarcoma, a malignant mesenchymal neoplasm, occurs mostly near the joints of the extremities and occasionally outside the joint such as lung.
  • We report a case of soft tissue sarcoma arising in the fallopian tube origin that showed characteristic pathological appearance of biphasic synovial sarcoma.
  • Molecular analysis detected a fusion gene transcript of synovial sarcoma translocation (SYT) gene from chromosome 18 and synovial sarcoma X chromosome breakpoint 1 (SSX1) gene, which is believed to pathognomonic for synovial sarcoma of joint origin.
  • This is the first report of a synovial sarcoma arising in the fallopian tube.
  • [MeSH-major] Fallopian Tube Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Base Sequence. Female. Humans. Oncogene Proteins, Fusion / genetics

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  • (PMID = 17197895.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
  • [Number-of-references] 12
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60. Sternheim A, Jin X, Shmookler B, Jelinek J, Malawer MM: 'Telangiectatic' transformation in soft tissue sarcomas. a clinicopathology analysis of an aggressive feature of high-grade sarcomas. Ann Surg Oncol; 2008 Jan;15(1):345-54
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  • Histological diagnoses were MFH (40%), leiomyosarcoma (15%), synovial sarcoma (10%), and one each of seven other sarcomas (35%).
  • [MeSH-major] Sarcoma / blood supply. Sarcoma / pathology. Telangiectasis / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Retrospective Studies. Soft Tissue Neoplasms / blood supply. Soft Tissue Neoplasms / pathology. Survival Rate

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  • (PMID = 17940825.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Sun BC, Sun Y, Zhao XL, Liu YX, Zhang SW, Liu YX: [Expressions and significance of E-cadherin and beta-catenin in synovial sarcoma]. Zhonghua Zhong Liu Za Zhi; 2005 Dec;27(12):727-30
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  • [Title] [Expressions and significance of E-cadherin and beta-catenin in synovial sarcoma].
  • OBJECTIVE: To explore the expression and significance of E-cadherin (E-cad) and beta-catenin (beta-cat) in synovial sarcoma.
  • METHODS: Expression of E-cad and beta-cat in 72 cases of synovial sarcoma were detected by tissue microarray technique and immunohistochemistry.
  • The background was clear and the contrast was vivid after immunohistochemistry. (2) The expression of E-cad was reduced in 56 patients (77.8%) and that of beta-cat was reduced in 51 patients (70.8%). (3) In patients with synovial sarcoma of monophasic fibrous type, grade III, and in patients with recurrence or metastasis, CK-negative and EMA-negative the rates of reduced expression of E-cad and beta-cat were significantly higher than those with primary sarcoma of biphasic type, grade II, CK-positive and EMA positive (P < 0.05 for all). (4) The survival of synovial sarcoma patients with E-cad and beta-cat expressions preserved was significantly better than those with reduced expressions (P = 0.012, P = 0.047).
  • [MeSH-major] Cadherins / biosynthesis. Extremities. Sarcoma, Synovial / metabolism. Soft Tissue Neoplasms / metabolism. beta Catenin / biosynthesis
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis. Tissue Array Analysis


62. Karalapillai D, Larobina M, Stevenson K, Doolan L: A change of heart: acute cardiac dextroversion with cardiogenic shock after partial lung resection. Crit Care Resusc; 2008 Jun;10(2):140-3
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  • This unusual case of acute right-sided cardiac dextroversion with torsion occurred in a 30-year-old man after radical right lower lobectomy, pericardial resection and a left lower-lobe wedge resection for locally recurrent and metastatic synovial sarcoma.
  • [MeSH-minor] Adult. Cardiac Surgical Procedures / methods. Diagnosis, Differential. Follow-Up Studies. Herniorrhaphy. Humans. Lung Neoplasms / surgery. Male. Postoperative Complications. Radiography, Thoracic

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  • (PMID = 18522529.001).
  • [ISSN] 1441-2772
  • [Journal-full-title] Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
  • [ISO-abbreviation] Crit Care Resusc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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63. Esaka EJ, Celebrezze JU, Golde SH, Chiossi G, Thomas RL: Pulmonary synovial sarcoma presenting as a pneumothorax during pregnancy. Obstet Gynecol; 2008 Feb;111(2 Pt 2):555-8
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  • [Title] Pulmonary synovial sarcoma presenting as a pneumothorax during pregnancy.
  • BACKGROUND: Synovial sarcoma is a clinically rare, but morphologically well-defined neoplasm, which accounts for approximately 10% of all malignant soft-tissue tumors.
  • CASE: We describe a case of primary pulmonary synovial sarcoma presenting as a pneumothorax in a young woman at 34 weeks of gestation.
  • The diagnosis was established by pathology and immunohistochemistry of the cells, which were consistent with primary pulmonary synovial sarcoma.
  • CONCLUSION: Malignancies, even those as uncommon as primary synovial sarcoma, should be considered in the differential diagnosis of pneumothorax during pregnancy.
  • [MeSH-major] Lung Neoplasms / diagnosis. Pneumothorax / etiology. Pregnancy Complications, Neoplastic / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Pregnancy


64. O'Donnell P, Diss TC, Whelan J, Flanagan AM: Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour/Ewing sarcoma: differentiation by molecular genetic studies. Skeletal Radiol; 2006 Apr;35(4):233-9
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  • [Title] Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour/Ewing sarcoma: differentiation by molecular genetic studies.
  • Synovial sarcoma (SS) arises in soft tissues but may invade adjacent bone.
  • Needle biopsy showed a "small round blue cell tumour", and a primitive neuroectodermal tumour (PNET)/Ewing sarcoma was suggested on the basis of the imaging appearances.
  • The definitive diagnosis of synovial sarcoma was made following molecular genetic studies, which demonstrated a fusion product incorporating the genes SYT and SSX1.
  • [MeSH-major] Bone Neoplasms / diagnosis. Neuroectodermal Tumors, Primitive / diagnosis. Sarcoma, Synovial / diagnosis. Ulna
  • [MeSH-minor] Adult. Diagnosis, Differential. Elbow Joint / diagnostic imaging. Elbow Joint / pathology. Humans. Male. Neoplasm Proteins / genetics. Proto-Oncogene Proteins / genetics. Radiography. Repressor Proteins / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16220269.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; 0 / SS18 protein, human; 164289-47-8 / synovial sarcoma X breakpoint proteins
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65. Ngahane BH, Baudrand H, Traverse-Glehen A, Freymond N, Guibert B, Pacheco Y, Devouassoux G: [Assessment of prognostic factors of thoracic synovial sarcoma]. Rev Mal Respir; 2010;27(1):93-7
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  • [Title] [Assessment of prognostic factors of thoracic synovial sarcoma].
  • INTRODUCTION: Synovial sarcoma is an uncommon tumour and thoracic involvement is rare and of varying location.
  • CASE REPORT: We report a case of synovial sarcoma of the chest wall, responsible for chronic local pain for several years, presenting as an acute pleuropneumonitis in a 21-year-old patient.
  • CONCLUSION: This case report reviews synovial sarcoma and underlines the difficulties and requirements of both diagnostic strategy and therapeutic management.
  • [MeSH-major] Sarcoma, Synovial / diagnosis. Thoracic Neoplasms / diagnosis. Thoracic Wall
  • [MeSH-minor] Biomarkers, Tumor / analysis. Combined Modality Therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Pleuropneumonia / diagnosis. Pleuropneumonia / pathology. Pneumonectomy. Prognosis. Radiotherapy, Adjuvant. Smoking / adverse effects. Thoracotomy. Young Adult

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  • (PMID = 20146960.001).
  • [ISSN] 1776-2588
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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66. Guo Z, Wang Z, Li J, Li XD: [Reconstruction with a new type of combined reconstruction following excision of periacetabular tumors]. Zhonghua Wai Ke Za Zhi; 2008 Jun 15;46(12):895-9
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  • Seventeen patients had primary malignant tumors including 7 chondrosarcomas, 4 osteosarcomas, 2 Ewing sarcomas, 2 malignant fibrohistiocytomas, 1 malignant Schwannomas, and 1 synovial sarcoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Arthroplasty, Replacement, Hip. Bone Screws. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19035146.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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67. Puhaindran ME, Athanasian EA: Double ray amputation for tumors of the hand. Clin Orthop Relat Res; 2010 Nov;468(11):2976-9
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  • All five patients had high-grade soft tissue sarcomas of the hand, two synovial sarcomas, two malignant peripheral nerve sheath tumors, and one undifferentiated sarcoma.
  • [MeSH-major] Amputation. Hand / surgery. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Disease-Free Survival. Hand Strength. Humans. Middle Aged. Neoplasm Recurrence, Local. New York City. Recovery of Function. Retrospective Studies. Time Factors. Treatment Outcome. Ulnar Nerve / physiopathology. Young Adult

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  • (PMID = 20490732.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2947675
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68. Aleagha ME, Montaseri A, Tahmasian M, Shobiri E, Torbaghan SS: Recurrent intracranial haemangiopericytoma compatible to synovial sarcoma. J Pak Med Assoc; 2010 Jul;60(7):586-8
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  • [Title] Recurrent intracranial haemangiopericytoma compatible to synovial sarcoma.
  • [MeSH-minor] Adult. Humans. Immunohistochemistry. Male. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Sarcoma, Synovial / diagnosis

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  • (PMID = 20578615.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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69. Makhlouf HR, Ahrens W, Agarwal B, Dow N, Marshalleck JJ, Lee EL, Dotto JE, Hui P, Sobin LH, Oliveira A, Miettinen M: Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases. Am J Surg Pathol; 2008 Feb;32(2):275-81
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  • [Title] Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases.
  • Only a few synovial sarcomas arising in the gastrointestinal tract have been reported, most of them are from the esophagus.
  • We report clinical, histopathologic, and immunohistochemical features of 10 gastric synovial sarcomas.
  • None of the patients had evidence of synovial sarcoma elsewhere.
  • Synovial sarcoma rarely occurs as a gastric primary tumor.
  • [MeSH-major] Sarcoma, Synovial / genetics. Sarcoma, Synovial / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / genetics. Combined Modality Therapy. DNA, Neoplasm. Female. Gastrectomy. Humans. Male. Middle Aged. Molecular Biology. Neoplasm Recurrence, Local. Oncogene Proteins, Fusion / analysis. Polymerase Chain Reaction

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  • (PMID = 18223331.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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70. Bode B, Frigerio S, Behnke S, Senn B, Odermatt B, Zimmermann DR, Moch H: Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma. Mod Pathol; 2006 Apr;19(4):541-7
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  • [Title] Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma.
  • The prognosis of patients with synovial sarcomas is poor.
  • New therapeutic strategies, such as target inhibition of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with erlotinib and gefinitib, could be effective, because most synovial sarcomas overexpress this protein.
  • To clarify the role of EGFR in synovial sarcoma and to explore the potential for a targeted therapy approach, we have examined 13 of these soft tissue tumors.
  • In contrast, several point mutations were identified in exons 18-21 of two synovial sarcomas.
  • In conclusion, strong EGFR expression in synovial sarcomas is not related to gene amplification.
  • The existence of mutations in the tyrosine kinase domain of the EGFR gene in a small subset of synovial sarcomas suggests that only few patients may profit from the tyrosine kinase inhibitor therapy.
  • [MeSH-major] Mutation. Receptor, Epidermal Growth Factor / genetics. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Binding Sites / genetics. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Molecular Sequence Data. Mutation, Missense. Point Mutation. Protein-Tyrosine Kinases / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16514409.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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71. Jun L, Ke S, Zhaoming W, Linjie X, Xinru Y: Primary synovial sarcoma of the prostate: report of 2 cases and literature review. Int J Surg Pathol; 2008 Jul;16(3):329-34
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  • [Title] Primary synovial sarcoma of the prostate: report of 2 cases and literature review.
  • Two cases of primary prostatic synovial sarcoma presenting as a prostatic mass are presented in patients aged 44 and 46 years.
  • To the authors' knowledge, these represent the fifth and sixth reported cases of prostatic synovial sarcoma.
  • [MeSH-major] Prostatic Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chromosomes, Human, Pair 18. Chromosomes, Human, X. DNA, Neoplasm / analysis. Epithelioid Cells / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Oncogene Proteins, Fusion / analysis. Reverse Transcriptase Polymerase Chain Reaction. Translocation, Genetic

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  • (PMID = 18387992.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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72. Davicioni E, Wai DH, Anderson MJ: Diagnostic and prognostic sarcoma signatures. Mol Diagn Ther; 2008;12(6):359-74
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  • [Title] Diagnostic and prognostic sarcoma signatures.
  • Sarcomas are a diverse group of childhood and adult tumors that arise from mesenchymal tissue.
  • Gene expression profiling or microarray analysis is now being used to develop expression signatures that appear to be better than histological features or any single biomarker at discriminating tumor types, identifying clinical variants, and modeling complex tumor behavior.This review examines the current progress in identifying diagnostic and prognostic expression signatures for four sarcomas: rhabdomyosarcoma, Ewing's family of tumors, synovial sarcoma, and osteosarcoma.
  • [MeSH-major] Sarcoma / diagnosis

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  • (PMID = 19035623.001).
  • [ISSN] 1177-1062
  • [Journal-full-title] Molecular diagnosis & therapy
  • [ISO-abbreviation] Mol Diagn Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Number-of-references] 200
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73. Vogel U, Wehrmann M, Eichhorn W, Bültmann B, Stiegler M, Wagner W: Molecular and clinicopathological findings in a tonsillar synovial sarcoma. A case study and review of the literature. Head Neck Pathol; 2010 Sep;4(3):257-60
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  • [Title] Molecular and clinicopathological findings in a tonsillar synovial sarcoma. A case study and review of the literature.
  • Synovial sarcoma (SS), 3-5% of which occurs in the head and neck region, has generally been regarded as high grade sarcoma.
  • [MeSH-major] Sarcoma, Synovial / pathology. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Disease-Free Survival. Humans. Male. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neoplasm Staging. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Repressor Proteins / genetics. Repressor Proteins / metabolism. Translocation, Genetic

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  • (PMID = 20625862.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; 0 / SS18 protein, human; 0 / SYT-SSX fusion protein; 164289-47-8 / synovial sarcoma X breakpoint proteins
  • [Other-IDs] NLM/ PMC2923310
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74. Katabathina VS, Vikram R, Nagar AM, Tamboli P, Menias CO, Prasad SR: Mesenchymal neoplasms of the kidney in adults: imaging spectrum with radiologic-pathologic correlation. Radiographics; 2010 Oct;30(6):1525-40
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  • Malignant renal tumors of mesenchymal origin include leiomyosarcoma, rhabdomyosarcoma, angiosarcoma, osteosarcoma, synovial sarcoma, fibrosarcoma, malignant fibrous histiocytoma, and solitary fibrous tumor.
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans

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  • [Copyright] © RSNA, 2010.
  • (PMID = 21071373.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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75. Jacobs S, Fox E, Krailo M, Hartley G, Navid F, Wexler L, Blaney SM, Goodwin A, Goodspeed W, Balis FM, Adamson PC, Widemann BC: Phase II trial of ixabepilone administered daily for five days in children and young adults with refractory solid tumors: a report from the children's oncology group. Clin Cancer Res; 2010 Jan 15;16(2):750-4
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  • PURPOSE: Ixabepilone is a microtubule-stabilizing agent with activity in adult solid tumors and in pediatric tumor xenograft models that are resistant to paclitaxel.
  • EXPERIMENTAL DESIGN: We conducted a phase II trial of ixabepilone (8 mg/m(2)/dose for 5 days every 21 days) using a two-stage design in taxane-naïve children and young adults with treatment-refractory, measurable rhabdomyosarcoma, Ewing sarcoma family tumors, osteosarcoma, synovial sarcoma, or malignant peripheral nerve sheath tumor, neuroblastoma, and Wilms tumor.
  • Seven patients received >or=3 cycles, and two had prolonged stable disease (Wilms' tumor, 38 cycles; synovial sarcoma, 8 cycles).

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  • (PMID = 20068084.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA098413; United States / NCI NIH HHS / CA / U10 CA 98543; United States / Intramural NIH HHS / / ; United States / NCI NIH HHS / CA / U10 CA098543-08; None / None / / U10 CA098543-08; United States / NCI NIH HHS / CA / U10 CA098543; United States / NCI NIH HHS / CA / U10 CA098413-08; None / None / / U10 CA098413-08
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Epothilones; K27005NP0A / ixabepilone
  • [Other-IDs] NLM/ NIHMS160304; NLM/ PMC3086796
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76. Du P, Yu LZ, Ma M, Geng L, Wang XS, Xin DQ, Na YQ: [Expression of SSX2 gene in human urologic neoplasms]. Zhonghua Wai Ke Za Zhi; 2005 Mar 15;43(6):379-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Gene Expression. Humans. Male. Middle Aged. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15854347.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 164289-47-8 / synovial sarcoma X breakpoint proteins
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77. Aljubran A, Tulba A, Akhtar S: Metastatic synovial sarcoma of the foot to the throat. Am J Clin Oncol; 2008 Apr;31(2):205-6
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  • [Title] Metastatic synovial sarcoma of the foot to the throat.
  • [MeSH-major] Bone Neoplasms / pathology. Calcaneus. Lung Neoplasms / secondary. Sarcoma, Synovial / secondary. Tonsillar Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 18391608.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Horvai AE, Kramer MJ, O'Donnell R: Beta-catenin nuclear expression correlates with cyclin D1 expression in primary and metastatic synovial sarcoma: a tissue microarray study. Arch Pathol Lab Med; 2006 Jun;130(6):792-8
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  • [Title] Beta-catenin nuclear expression correlates with cyclin D1 expression in primary and metastatic synovial sarcoma: a tissue microarray study.
  • In synovial sarcoma (SS), aberrant beta-catenin expression has prognostic relevance, but the association with cyclin D1 has not been established.
  • [MeSH-major] Cyclin D1 / metabolism. Sarcoma, Synovial / metabolism. Soft Tissue Neoplasms / metabolism. Tissue Array Analysis. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / chemistry. Cell Nucleus / metabolism. Cell Nucleus / pathology. Chromosomes, Human, Pair 18 / genetics. Chromosomes, Human, X / genetics. Extremities. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Male. Middle Aged. Survival Rate. Translocation, Genetic


79. Block KI, Gyllenhaal C, Newman RA: Response to 'Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee'. J Altern Complement Med; 2009 Dec;15(12):1269; author reply 1271
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  • [Title] Response to 'Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee'.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Drug-Induced Liver Injury / etiology. Nerium / toxicity. Plant Extracts / adverse effects. Plant Poisoning. Sarcoma, Synovial / drug therapy
  • [MeSH-minor] Adult. Animals. Female. Humans. Knee Joint. Lung Neoplasms / secondary

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  • (PMID = 19958106.001).
  • [ISSN] 1557-7708
  • [Journal-full-title] Journal of alternative and complementary medicine (New York, N.Y.)
  • [ISO-abbreviation] J Altern Complement Med
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Plant Extracts
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80. Duband S, Morrison AL, Pasquier D, Coindre JM, Pasquier B, Péoc'h M: First case report of a fetal synovial sarcoma confirmed by molecular detection of SYT-SSX fusion gene transcripts. Am J Perinatol; 2008 Sep;25(8):517-20
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  • [Title] First case report of a fetal synovial sarcoma confirmed by molecular detection of SYT-SSX fusion gene transcripts.
  • Synovial sarcomas are aggressive malignant soft tissue tumors typically observed in adolescents and young adults.
  • We describe the first case of synovial sarcoma observed in a human fetus.
  • The positive detection of the SYT-SSX1 fusion transcripts with reverse-transcription polymerase chain reaction in formalin-fixed and paraffin-embedded tissue confirmed the synovial sarcoma diagnosis.
  • [MeSH-major] Biomarkers, Tumor / genetics. Fetal Diseases / diagnosis. Oncogene Proteins, Fusion / genetics. Sarcoma, Synovial / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Arm. Fatal Outcome. Female. Humans. Immunohistochemistry. Keratins / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Translocation, Genetic

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  • (PMID = 18720326.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein; 68238-35-7 / Keratins
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81. Sefiani S, Amarti A, Boulaadas M, Maher M, Saidi A: [Synovial sarcoma of the head and neck: two cases report]. Rev Laryngol Otol Rhinol (Bord); 2005;126(1):53-6
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  • [Title] [Synovial sarcoma of the head and neck: two cases report].
  • Synovial sarcomas are soft tissue tumors that rarely occur in the head and neck The purpose of this report is to accrue data on this sarcoma at a rare site, and to highlight the histopathological differential diagnosis with other cervical tumors.
  • DISCUSSION: Synovial sarcomas are a rare soft tissue malignancies and the head and neck region location accounts for 3-5% of them.
  • The poor prognosis of this sarcoma justified a radical surgery with post-operative radiotherapy.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Fibrosarcoma / pathology. Humans. Mouth Floor / pathology. Mouth Neoplasms / diagnosis. Mouth Neoplasms / pathology. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16080650.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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82. Zhao Q, Geha AS, Devries SR, Tshibaka C, Wu SJ, Lavi N, Massad M, Chomka EV: Biatrial primary synovial sarcoma of the heart. J Am Soc Echocardiogr; 2007 Feb;20(2):197.e1-4
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  • [Title] Biatrial primary synovial sarcoma of the heart.
  • Synovial sarcomas that primarily arise from the heart and pericardium are extremely rare, especially the ones involving both sides of the heart.
  • Our patient was a 36-year-old man who presented with primary biatrial synovial sarcoma that also involved the tricuspid annulus, heart valves, and interatrial septum.
  • Molecular analysis confirmed the diagnosis of synovial sarcoma with positive t (X;18) SYT-SSX gene fusion.
  • [MeSH-major] Heart Neoplasms / pathology. Heart Neoplasms / ultrasonography. Sarcoma, Synovial / pathology. Sarcoma, Synovial / ultrasonography
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17275707.001).
  • [ISSN] 1097-6795
  • [Journal-full-title] Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
  • [ISO-abbreviation] J Am Soc Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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83. Iwasaki T, Koibuchi N, Chin WW: Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Endocrinology; 2005 Sep;146(9):3892-9
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  • [Title] Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator.
  • A database search revealed that CoAA is identical with synovial sarcoma translocation (SYT)-interacting protein.
  • However, we could not detect SYT-L in adult tissues.


84. Jiang J, Zhou J, Ding W: Primary pulmonary synovial sarcoma, a rare primary lung neoplasm: two case reports and review of the current literature. Respirology; 2008 Sep;13(5):748-50
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  • [Title] Primary pulmonary synovial sarcoma, a rare primary lung neoplasm: two case reports and review of the current literature.
  • This report describes the clinical, histological and immunohistochemical features of two patients with primary pulmonary synovial sarcoma in the context of the literature.
  • [MeSH-major] Lung Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Chest Pain / etiology. Cough / etiology. Humans. Keratins / metabolism. Male. Middle Aged. Vimentin / metabolism

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  • (PMID = 18713096.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 10
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85. Parfitt JR, Xu J, Kontozoglou T, Oluwafemi AR, Driman DK: Primary monophasic synovial sarcoma of the colon. Histopathology; 2007 Mar;50(4):521-3
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  • [Title] Primary monophasic synovial sarcoma of the colon.
  • [MeSH-major] Colonic Neoplasms / pathology. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17448034.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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86. Rekhi B, Desai SB, Arya S, Kane SV, Jambhekar NA: Metastatic synovial sarcoma, masquerading a carcinoma from a tonsillar primary: a rare case presentation. Indian J Pathol Microbiol; 2010 Jul-Sep;53(3):582-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic synovial sarcoma, masquerading a carcinoma from a tonsillar primary: a rare case presentation.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / pathology. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / secondary. Tonsillar Neoplasms / diagnosis. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Head / radiography. Histocytochemistry. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Microscopy. Mucin-1 / analysis. Neck / radiography. Proto-Oncogene Proteins c-bcl-2 / analysis. Reticulin / analysis

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  • (PMID = 20699542.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Reticulin
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87. Nakagawa Y, Numoto K, Yoshida A, Kunisada T, Ohata H, Takeda K, Wai D, Poremba C, Ozaki T: Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization. J Cancer Res Clin Oncol; 2006 Jul;132(7):444-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization.
  • PURPOSE: To analyze the relationship between chromosomal instabilities and clinicopathological factors in synovial sarcoma (SS).
  • [MeSH-major] Chromosomal Instability. Microarray Analysis. Nucleic Acid Hybridization. Sarcoma, Synovial / genetics. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Metaphase. Middle Aged. Predictive Value of Tests. Prognosis. Survival Analysis


88. Pelosi G, Luzzatto F, Landoni F, Staffa N, Maggioni A, Braidotti P, Cabras A, Aiello A, Del Curto B, Viale G: Poorly differentiated synovial sarcoma of the vagina: first reported case with immunohistochemical, molecular and ultrastructural data. Histopathology; 2007 May;50(6):808-10
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  • [Title] Poorly differentiated synovial sarcoma of the vagina: first reported case with immunohistochemical, molecular and ultrastructural data.
  • [MeSH-major] Sarcoma, Synovial / diagnosis. Vagina / metabolism. Vagina / ultrastructure. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Adult. DNA, Neoplasm / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Mucin-1 / genetics. Mucin-1 / metabolism. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Repressor Proteins / genetics. Repressor Proteins / metabolism. Vimentin / genetics. Vimentin / metabolism

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  • (PMID = 17355275.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Mucin-1; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; 0 / SS18 protein, human; 0 / Vimentin
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89. Harb WJ, Luna MA, Patel SR, Ballo MT, Roberts DB, Sturgis EM: Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck; 2007 Aug;29(8):731-40
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  • [Title] Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension.
  • BACKGROUND: The medical literature on synovial sarcoma (SS) of the head and neck region is limited.
  • [MeSH-major] Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / surgery. Neoplasm Recurrence, Local / epidemiology. Sarcoma, Synovial / mortality. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Linear Models. Male. Medical Records. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Texas / epidemiology. Treatment Outcome

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  • (PMID = 17274049.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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90. Bond M, Bernstein ML, Pappo A, Schultz KR, Krailo M, Blaney SM, Adamson PC: A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer; 2008 Feb;50(2):254-8
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  • Ewing sarcoma, osteosarcoma, neuroblastoma, desmoplastic small round cell, and synovial sarcomas often overexpress KIT or the PDGF receptor.
  • PROCEDURE: Patients less than 30 years of age with refractory or recurrent Ewing sarcoma, osteosarcoma, neuroblastoma, desmoplastic small round cell, synovial sarcomas or GIST were eligible.
  • Only one partial response was seen among 24 patients with Ewing sarcoma.
  • CONCLUSION: Imatinib as a single agent at a dose of 440 mg/m(2)/day demonstrated little or no activity as a single agent in children with relapsed or refractory Ewing sarcoma, osteosarcoma, neuroblastoma, or desmoplastic small round cell tumors.
  • [MeSH-minor] Adolescent. Adult. Benzamides. Bone Neoplasms / drug therapy. Carcinoma, Small Cell / drug therapy. Child. Child, Preschool. Female. Gastrointestinal Stromal Tumors / drug therapy. Humans. Imatinib Mesylate. Male. Neuroblastoma / drug therapy. Osteosarcoma / drug therapy. Sarcoma, Ewing / drug therapy. Sarcoma, Synovial / drug therapy

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17262795.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U10 CA 98543
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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91. Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, Rosenberg AE, Nielsen GP, DeLaney TF, Chen YL, Ott MJ, Yoon SS: Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol; 2009 May;16(5):1356-63
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  • [Title] Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas.
  • BACKGROUND: Soft tissue sarcomas generally have a </=5% risk of lymph node metastasis, but synovial, epithelioid, and clear cell subtypes reportedly have a much higher risk.
  • The utility of sentinel lymph node biopsy (SLNB) for patients with these sarcoma subtypes is unknown.
  • METHODS: 29 patients with nonmetastatic synovial, epithelioid, and clear cell sarcomas who underwent SLNB were examined.
  • The histological subtypes were synovial sarcoma in 16 patients, epithelioid sarcoma in 10, and clear cell sarcoma in 3.
  • CONCLUSION: For patients with these sarcoma subtypes without radiological evidence of nodal or distant metastases, the incidence of occult lymph node metastasis is relatively low.
  • [MeSH-major] Sarcoma / pathology. Sarcoma, Clear Cell / pathology. Sarcoma, Synovial / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Extremities. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Young Adult

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  • (PMID = 19259743.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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92. Stacy GS, Nair L: Magnetic resonance imaging features of extremity sarcomas of uncertain differentiation. Clin Radiol; 2007 Oct;62(10):950-8
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  • The purpose of this review is to illustrate the pertinent clinical and imaging features of extremity sarcomas of uncertain differentiation, including synovial sarcoma, epithelioid sarcoma, clear-cell sarcoma, and alveolar soft part sarcoma.
  • These tumours should be considered in the differential diagnosis when a soft-tissue mass is encountered in the extremity of an adolescent or young adult.
  • [MeSH-major] Forearm. Leg. Magnetic Resonance Imaging. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Clin Radiol. 2007 Oct;62(10):959-60 [17765460.001]
  • (PMID = 17765459.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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93. Zhang HY, Ke Q, Zhang Z, Zhang R, Fu J, Chen HJ, Wei B, Bu H: [Expression of beta-catenin and estrogen receptor in desmoid-type fibromatosis]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2010 Jan;41(1):101-5
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  • METHODS: Nuclear beta-catenin expression was detected by immunohistochemistry in 77 lesions with desmoid-type fibromatosis and 171 other spindle cell lesions, including superficial fibromatosis (n = 18), nodular fasciitis (n = 36), keloid (n = 16), scar (n = 10), granulation tissue (n = 9), synovial sarcoma (n = 38), neufibroma (n = 13), solitary fibrous tumor (n =12), gastrointestinal stromal tumor (n = 10), low-grade myxofibrosarcoma (n = 3), low-grade fibromyxoid sarcoma (n = 3), and smooth muscle tumor (n = 10).
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Young Adult

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  • (PMID = 20369480.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / beta Catenin
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94. Nishiyama N, Iwata T, Izumi N, Tsukioka T, Nagano K, Suehiro S: Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura. Ann Thorac Cardiovasc Surg; 2009 Feb;15(1):46-9
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  • [Title] Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura.
  • Pleural synovial sarcomas are an extremely rare disease entity, and only 21 surgical cases, including this one, have been reported.
  • We present a case of synovial sarcoma that underwent pneumonectomy for a recurrence of the disease.
  • A 31-year-old female, who in June 2005 had undergone surgical resection of a monophasic synovial sarcoma in the left pleural cavity combined with the affected left diaphragm, was admitted to our hospital in January 2007 and underwent chemotherapy with ifosfamide, pirarubicin, and methotrexate for a recurrent synovial sarcoma in the left pleural cavity.
  • Pathological examination revealed dense proliferation of atypical spindle cells, the same findings as in the initial operation, and a diagnosis of synovial sarcoma was made.
  • Although optimal strategies for synovial sarcoma have yet to be established, aggressive repeat surgery could be considered in selected cases even when response to chemotherapy is insufficient and complete resection is difficult.
  • [MeSH-major] Neoplasm Recurrence, Local. Pleural Neoplasms / surgery. Pneumonectomy. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Radiotherapy, Adjuvant. Reoperation. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19262450.001).
  • [ISSN] 2186-1005
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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95. Drozenová J, Povýsil C, Tvrdík D, Babjuk M, Hanus T: [Primary synovial sarcoma of the kidney]. Cesk Patol; 2008 Jan;44(1):20-2
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  • [Title] [Primary synovial sarcoma of the kidney].
  • The authors present two cases of primary synovial sarcoma of the kidney.
  • In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.
  • [MeSH-major] Kidney Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 18333330.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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96. Taylor CA, Barnhart A, Pettenati MJ, Geisinger KR: Primary pleuropulmonary synovial sarcoma diagnosed by fine needle aspiration with cytogenetic confirmation: a case report. Acta Cytol; 2005 Nov-Dec;49(6):673-6
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  • [Title] Primary pleuropulmonary synovial sarcoma diagnosed by fine needle aspiration with cytogenetic confirmation: a case report.
  • BACKGROUND: Pleuropulmonary synovial sarcomas (PPSSs) are rare neoplasins that have been well described in recent years, although there are only very infrequent reports within the cytology literature.
  • [MeSH-major] Cytogenetic Analysis / methods. Lung Neoplasms / diagnosis. Pleural Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Humans. Male. Sensitivity and Specificity. Tomography, X-Ray Computed / methods

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  • (PMID = 16450912.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Long JA, Dinia EM, Saada-Sebag G, Cyprien J, Pasquier D, Thuillier C, Terrier N, Boillot B, Descotes JL, Rambeaud JJ: [Primitive renal synovial sarcoma: a cystic tumor in young patients]. Prog Urol; 2009 Jul;19(7):474-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primitive renal synovial sarcoma: a cystic tumor in young patients].
  • INTRODUCTION: The study of the clinical, histological and immunohistochemical aspects of three kidney tumors corresponding to synovial sarcomas operated on in our center over three years.
  • PATIENTS AND METHOD: Three patients aged between 27 and 33 had an enlarged nephrectomy for kidney tumors corresponding to a histological examination of a synovial sarcoma.
  • The histology found a mesenchymal fusocellular monotone proliferation corresponding to a sarcoma.
  • CONCLUSION: Primitive synovial sarcoma of the kidney occured in young patients.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cysts / diagnosis. Kidney Neoplasms / diagnosis. Oncogene Proteins, Fusion / analysis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Back Pain / etiology. Female. Hematoma / etiology. Humans. Immunohistochemistry. Male. Nephrectomy / methods. Prognosis. Retrospective Studies. Reverse Transcriptase Polymerase Chain Reaction. Rupture, Spontaneous. Survival Analysis. Translocation, Genetic. Treatment Outcome

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  • [CommentIn] Prog Urol. 2009 Jul;19(7):479-80 [19559378.001]
  • (PMID = 19559377.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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98. Herzog CE: Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol; 2005 Apr;27(4):215-8
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  • [Title] Overview of sarcomas in the adolescent and young adult population.
  • However, there are numerous different histologic types, and any given type of sarcoma is extremely rare.
  • In an effort to estimate the frequency and absolute numbers of different sarcomas in the adolescent and young adult population, the University of Texas M. D.
  • Based on this query, an overview of sarcomas that occur predominantly in the adolescent and young adult (AYA) population is presented.
  • These sarcomas include rhabdomyosarcoma, synovial sarcoma, neurogenic sarcoma, epithelioid sarcomas, alveolar soft parts sarcoma, Ewing sarcoma, and osteosarcoma.
  • Using the percentages for occurrence of each histologic type determined from the MDACC database, and the SEER estimate of overall sarcoma incidence, an estimate of the number of new cases in 2004 for the predominant histologic types occurring in the AYA population are presented.
  • [MeSH-major] Bone Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Humans. Middle Aged. SEER Program

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  • (PMID = 15838394.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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99. Qubbany AW, Kinsara AJ: Metastatic synovial sarcoma to the left atrium. A management dilemma. Saudi Med J; 2007 Dec;28(12):1904-6
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  • [Title] Metastatic synovial sarcoma to the left atrium. A management dilemma.
  • We present a rare case of synovial sarcoma with minimal symptoms that metastasized and threatened to embolize the heart in a 26-year-old male admitted to our hospital for evaluation of low back pain.
  • [MeSH-major] Heart Neoplasms / secondary. Heart Neoplasms / therapy. Sarcoma, Synovial / secondary. Sarcoma, Synovial / therapy
  • [MeSH-minor] Adult. Heart Atria. Humans. Male. Prognosis

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  • (PMID = 18060227.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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100. Ammar A, El Hammami S, Sellami Kamoun N: [Unusual site of primary synovial sarcoma: the lung]. Rev Mal Respir; 2006 Jun;23(3 Pt 1):285-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Unusual site of primary synovial sarcoma: the lung].
  • [MeSH-major] Lung Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 16788532.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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