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1. Barton VN, Donson AM, Kleinschmidt-DeMasters BK, Birks DK, Handler MH, Foreman NK: Unique molecular characteristics of pediatric myxopapillary ependymoma. Brain Pathol; 2010 May;20(3):560-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clinical trial design requires a better understanding of tumor biology.
  • The upregulation of three genes of interest, homeobox B13 (HOXB13), neurofilament, light polypeptide (NEFL) and PDGFR alpha, was further studied by immunohistochemistry in a larger cohort that included adult MEPN and EPN specimens.
  • Protein expression in MEPN was compared to subependymoma, spinal EPN, intracranial EPN and normal fetal and adult ependyma.
  • Spinal and intracranial EPN generally expressed weak or focal staining.
  • [MeSH-major] Ependymoma / genetics. Ependymoma / metabolism. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Spinal Cord Neoplasms / genetics. Spinal Cord Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Cohort Studies. Female. Humans. Male. Retrospective Studies

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  • (PMID = 19793339.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins
  • [Other-IDs] NLM/ PMC2871180
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2. Kumar S, Jain AK, Dhammi IK, Aggarwal AN: Treatment of intraspinal tuberculoma. Clin Orthop Relat Res; 2007 Jul;460:62-6
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  • Neurological manifestations in spinal tuberculosis often occur secondary to vertebral involvement.
  • However, tuberculoma of the spinal cord or extradural granuloma without radiological evidence of vertebral involvement may be responsible for neurological complications.
  • Only four patients had spinal tenderness, and bone involvement could be seen on plain radiographs in only three patients.
  • Intraspinal tubercular granuloma should be considered in the differential diagnosis when a case of spinal tumor syndrome is encountered in an endemic zone of tuberculosis.
  • [MeSH-major] Tuberculoma / therapy. Tuberculosis, Spinal / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antitubercular Agents / therapeutic use. Combined Modality Therapy. Decompression, Surgical. Female. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Paraplegia / etiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 17452917.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents
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3. Dağli M, Acar A, Eryilmaz A, Göçer C: [Unusual distant metastasis of larynx carcinoma: a case report]. Kulak Burun Bogaz Ihtis Derg; 2007;17(1):37-9
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  • The tumor spread may be by a lymphatic or nonlymphatic route.
  • Indirect laryngoscopic examination showed a vegetable mass extending from the left laryngeal side of the epiglottis to the left vocal cord.
  • Magnetic resonance imaging performed due to complaints of back pain and foot numbness demonstrated aggressive spinal cord metastases.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Neoplasm Metastasis

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  • (PMID = 17483610.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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4. Che XM, Xu QW, Shou JJ, Gu SX, Zhang MG, Sun B, Cui DM: [The diagnosis and surgical management for intramedullary spinal cord cavernous angioma]. Zhonghua Yi Xue Za Zhi; 2008 May 20;88(19):1306-8
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  • [Title] [The diagnosis and surgical management for intramedullary spinal cord cavernous angioma].
  • OBJECTIVE: The clinical diagnosis and surgical management of intramedullary spinal cord cavernous angioma were discussed.
  • RESULT: All the 19 patients pathologically diagnosed with spinal cord cavernous angioma got good surgical results, besides one patient showed loss of proprioception.
  • CONCLUSION: The clinical symptom of most of the patients with spinal cord cavernous angioma presented mildly at onset, but deteriorated gradually because of repeated prehemorrhage.
  • Dissection should be done between the tumor and the gliosis during the surgical procedure, special attention should be paid to avoiding tumor residual.
  • It was not necessary to aggressively evacuate the hematoma derived from tumor hemorrhage, which extended along the central canal up and down, except obvious occupied syndrome exited.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 18956697.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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5. Ito K, Matsuyama Y, Yukawa Y, Kato F, Ishiguro N: Analysis of interleukin-8, interleukin-10, and tumor necrosis factor-alpha in the cerebrospinal fluid of patients with cervical spondylotic myelopathy. J Spinal Disord Tech; 2008 Apr;21(2):145-7
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  • [Title] Analysis of interleukin-8, interleukin-10, and tumor necrosis factor-alpha in the cerebrospinal fluid of patients with cervical spondylotic myelopathy.
  • OBJECTIVE: The expression of interleukin-8 (IL-8), IL-10, and tumor necrosis factor-alpha (TNF-alpha) were measured in the cerebrospinal fluid (CSF) of patients with cervical myelopathy.
  • [MeSH-major] Interleukin-10 / cerebrospinal fluid. Interleukin-8 / cerebrospinal fluid. Spinal Cord Diseases / cerebrospinal fluid. Spinal Osteophytosis / cerebrospinal fluid. Tumor Necrosis Factor-alpha / cerebrospinal fluid
  • [MeSH-minor] Adult. Aged. Cervical Vertebrae. Cohort Studies. Female. Humans. Male. Middle Aged. Ossification of Posterior Longitudinal Ligament / cerebrospinal fluid. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18391721.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-8; 0 / Tumor Necrosis Factor-alpha; 130068-27-8 / Interleukin-10
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6. Feng J, Xu YK, Li L, Yang RM, Ye XH, Zhang N, Yu T, Lin BQ: MRI diagnosis and preoperative evaluation for pure epidural cavernous hemangiomas. Neuroradiology; 2009 Nov;51(11):741-7
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  • INTRODUCTION: The aims of the study were to summarize the characteristics of the spinal epidural cavernous hemangioma, especially for the MRI, and to improve the accurate rate of the preoperative diagnosis.
  • METHODS: The clinical and medical imaging data of six patients with pure spinal epidural cavernous hemangioma proved by operation and pathology were analyzed retrospectively.
  • The tumor showed lobulated contour, and the areas the tumors appeared were dorsal side of spinal cord (n = 2), ventral side (n = 1), and lateral side (n = 3).
  • In all six patients, the lesions were isointense to the spinal cord on T(1)-weighted images and hyperintense on T(2)-weighted images and showed homogeneously strong enhancement on contrast-enhanced T(1)-weighted images.
  • CONCLUSIONS: MRI of the epidural cavernous hemangioma showed the characteristic lobulated contour, which encircled the spinal cord.
  • MR imaging has an important role in the detection and diagnosis of pure spinal epidural cavernous hemangioma.
  • [MeSH-major] Epidural Neoplasms / pathology. Hemangioma, Cavernous, Central Nervous System / pathology. Magnetic Resonance Imaging / methods. Preoperative Care / methods. Spinal Cord / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Lumbar Vertebrae. Male. Middle Aged. Photomicrography. Retrospective Studies. Sacrum. Thoracic Vertebrae

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  • [ISSN] 1432-1920
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7. Jin R, Rock J, Jin JY, Janakiraman N, Kim JH, Movsas B, Ryu S: Single fraction spine radiosurgery for myeloma epidural spinal cord compression. J Exp Ther Oncol; 2009;8(1):35-41
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  • [Title] Single fraction spine radiosurgery for myeloma epidural spinal cord compression.
  • It has been demonstrated that spine radiosurgery can be safely used for treatment of spine metastasis with rapid and durable pain control, but without detrimental effects to the spinal cord.
  • This study was carried out to determine the role of single fraction radiosurgery for epidural spinal cord compression due to multiple myeloma.
  • A total of 31 lesions in 24 patients with multiple myeloma, who presented with epidural spinal cord compression, were treated with spine radiosurgery.
  • Single fraction radiation dose of 10-18 Gy (median of 16 Gy) was administered to the involved spine including the epidural or paraspinal tumor.
  • Primary endpoints of this study were pain control, neurological improvement, and radiographic tumor control.
  • Complete radiographic response of the epidural tumor was noted in 81% at 3 months after radiosurgery.
  • Single fraction radiosurgery achieved an excellent clinical and radiographic response of myeloma epidural spinal cord compression.
  • [MeSH-major] Multiple Myeloma / complications. Radiosurgery / methods. Spinal Cord Compression / surgery. Spine / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Epidural Space. Female. Humans. Male. Middle Aged

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  • (PMID = 19827269.001).
  • [ISSN] 1359-4117
  • [Journal-full-title] Journal of experimental therapeutics & oncology
  • [ISO-abbreviation] J. Exp. Ther. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Mawrin C, Perry A: Pathological classification and molecular genetics of meningiomas. J Neurooncol; 2010 Sep;99(3):379-91
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  • Meningiomas are extremely common adult brain tumors originating from meningeal coverings of the brain and spinal cord.
  • In addition to alterations of CDKN2A, p14(ARF), and CDKN2B tumor suppressor genes on 9p21, a contribution of the wingless (wnt) pathway with alterations of the E-cadherin and beta-catenin proteins, as well as alterations of the hedgehog signaling pathway have been implicated in anaplastic meningiomas.

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  • (PMID = 20809251.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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9. Li D, Brennan JW, Buckland M, Parkinson JF: Bronchogenic carcinoid metastasis to the intramedullary spinal cord. J Clin Neurosci; 2010 Sep;17(9):1196-8
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  • [Title] Bronchogenic carcinoid metastasis to the intramedullary spinal cord.
  • Spinal-cord compression from carcinoid metastasis is uncommon, and intradural spinal carcinoid is rare.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Carcinoma, Bronchogenic / diagnosis. Lung Neoplasms / diagnosis. Spinal Cord Compression / diagnosis. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Female. Humans

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  • [Copyright] Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20627579.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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10. Kułakowska A, Pogorzelski R, Drozdowski W: [Primary central nervous system lymphoma with initial symptoms suggesting herpes encephalitis]. Pol Merkur Lekarski; 2008 Jan;24(139):30-3
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  • Primary central nervous system lymphoma (PCNSL) is rare neoplasm, affecting both immunocompetent and immunodeficient patients.
  • It is usually seen as intracranial tumor, but it can often involve cerebrospinal meninges, eyeballs and spinal cord.
  • We described a case of 43 year old patient with diagnosed PCNSL and discussed clinical signs, diagnostics and treatment of the neoplasm.
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Diagnosis, Differential. Fatal Outcome. Humans. Male

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  • (PMID = 18634249.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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11. Yang S, Yang X, Hong G: Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors. Spine (Phila Pa 1976); 2009 Nov 15;34(24):2705-10
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  • [Title] Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors.
  • STUDY DESIGN: A retrospective study of microsurgical treatment of intramedullary spinal cord tumors (IMSCT) was conducted.
  • The optimum treatment of those tumors is controversial, with the recent advance, the operation of IMSCTs has became safer and total resection of most those tumor is possible.
  • METHODS: Data from 174 IMSCTs operated on in the last 20 years are analyzed retrospectively by the tumors' anatomic locations, histologic types, symptoms and signs, tumor removal rate, and operative outcomes.
  • RESULTS: In this group ependymoma was the commonest tumor (48.9%), the second most often seen being astrocytoma (35.6%).
  • Total resection of the tumor was possible in 60.9% of patients, subtotal resection in 17.2%, and partial resection in 13.8%.
  • On long-term follow-up there was improvement in 70.2%, no change in 19.5%, deterioration in 4%, tumor recurrence in 6.9%, with 6.3% of patients dying.
  • CONCLUSION: Most intramedullary spinal cord tumors need operative treatment as early as possible.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Aged. Child. Child, Preschool. Decompression, Surgical / methods. Disability Evaluation. Early Diagnosis. Female. Humans. Infant. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Outcome Assessment (Health Care). Pain / etiology. Paralysis / etiology. Retrospective Studies. Sensation Disorders / etiology. Treatment Outcome. Urinary Bladder, Neurogenic / etiology. Young Adult

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  • (PMID = 19910775.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Petit A, Sellers DL, Liebl DJ, Tessier-Lavigne M, Kennedy TE, Horner PJ: Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Proc Natl Acad Sci U S A; 2007 Nov 6;104(45):17837-42
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  • [Title] Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.
  • Adult neural progenitor cells (aNPCs) exhibit limited migration in vivo with the exception of the rostral migratory stream and injury-induced movement.
  • These studies demonstrate that aNPCs respond principally to a repulsive cue expressed at the embryonic floor plate (FP) and also the injured adult CNS.
  • Adult spinal cord progenitor cells (aSCPs) were seeded onto organotypic slice preparations of the intact embryonic or injured adult spinal cord.
  • When slices were prepared from injured spinal cord, aSCP migration away from the injury core was Ntn-1-dependent.

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  • (PMID = 17978191.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / PHS HHS / / R01 N546724
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nerve Growth Factors; 0 / Tumor Suppressor Proteins; 147336-22-9 / Green Fluorescent Proteins; 158651-98-0 / netrin-1
  • [Other-IDs] NLM/ PMC2077035
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13. Guan YG, Wang TH, Ni W, Li L, Lu YC, Gao ZY: [Distribution of Fas and FasL in the central nervous system of adult rhesus]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2005 May;36(3):322-4
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  • [Title] [Distribution of Fas and FasL in the central nervous system of adult rhesus].
  • OBJECTIVE: To investigate the distribution of Fas and FasL in the CNS of adult rhesus.
  • Fas immunoreactivity could be seen in the cytoplasm and processes of Purkinje cells and in the brain stem nuclei, including vestibular nucleus, dorsal nucleus of vagus and spinal nucleus of trigeminal nerve.
  • FasL immunopositive neurons were observed in cerebral cortex, especially in pyramidal neurons of lamina I and V, cerebellar nuclei, diencephalon, and brain stem nuclei involving pontine nucleus, vestibular nucleus, cochlear nucleus, spinal nucleus of trigeminal nerve, hypoglossal nucleus, nucleus ambiguous and reticular formation.
  • Fas and FasL immunoreactivity mainly distributed in motor neurons of spinal ventral horn and neural fibers and glia cells in white matter.
  • [MeSH-major] Antigens, CD95 / metabolism. Brain Chemistry. Membrane Glycoproteins / metabolism. Tumor Necrosis Factors / metabolism
  • [MeSH-minor] Animals. Brain Stem / chemistry. Cerebral Cortex / chemistry. Fas Ligand Protein. Macaca mulatta. Male. Spinal Cord / chemistry. Tissue Distribution. Vestibular Nuclei / chemistry

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  • (PMID = 15931857.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins; 0 / Tumor Necrosis Factors
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14. Acosta FL Jr, Dowd CF, Chin C, Tihan T, Ames CP, Weinstein PR: Current treatment strategies and outcomes in the management of symptomatic vertebral hemangiomas. Neurosurgery; 2006 Feb;58(2):287-95; discussion 287-95
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  • Seven of nine patients undergoing surgical decompression and tumor resection reported pain relief and demonstrated improvement in neurological deficit when present.
  • All three patients undergoing vertebrectomy had cord compression from extraosseous tumor growth.
  • CONCLUSION: Transarterial embolization followed by laminectomy is a safe and effective procedure for the treatment of cord compression by vertebral hemangioma causing stenosis without instability or deformity.
  • Vertebrectomy preceded by embolization and followed by reconstruction can be used to treat cord compression from extraosseous tumor extension.
  • [MeSH-major] Hemangioma / therapy. Lumbar Vertebrae / surgery. Spinal Neoplasms / therapy. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Decompression, Surgical / methods. Disease Management. Embolization, Therapeutic / methods. Female. Follow-Up Studies. Humans. Laminectomy / methods. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 16462482.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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15. Kwon YM, Kim KS, Kuh SU, Chin DK, Jin BH, Cho YE: Survival rate and neurological outcome after operation for advanced spinal metastasis (Tomita's classification > or = type 4). Yonsei Med J; 2009 Oct 31;50(5):689-96
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  • [Title] Survival rate and neurological outcome after operation for advanced spinal metastasis (Tomita's classification > or = type 4).
  • PURPOSE: We investigated whether primary malignancy entities and the extent of tumor resection have an effect on the survival rate and neurological improvement in patients with spinal metastases that extend beyond the vertebral compartment (Tomita's classification > or = type 4).
  • MATERIALS AND METHODS: We retrospectively reviewed 87 patients with advanced spinal metastasis who underwent surgery.
  • They were subdivided according to the extent of tumor resection: group 1, gross total resection (G1GT); group 1, subtotal resection (G1ST); group 2, gross total resection (G2GT); and group 2, subtotal resection (G2ST).
  • The origin of the tumor, survival rate, extent of resection, and neurological improvement were analyzed.
  • In group 2, the extent of tumor resection (G2GT vs. G2ST) did not affect survival rate.
  • Four out of 13 patients in the G2GT subgroup showed a local recurrence of spinal tumors and progressive worsening of neurological status.
  • CONCLUSION: In patients with spinal metastases (Tomita's classification > or = type 4), individuals who underwent gross total resection of tumors that responded to adjuvant therapy showed a higher survival rate than those who underwent subtotal resection.
  • [MeSH-major] Spinal Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Combined Modality Therapy. Diagnostic Techniques, Neurological. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 19881974.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2768245
  • [Keywords] NOTNLM ; Bone neoplasm / decision making / metastasis / prognosis
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16. Bohner G, Masuhr F, Distl R, Katchanov J, Klingebiel R, Zschenderlein R, von Deimling A, van Landeghem FK: Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. Acta Neuropathol; 2005 Sep;110(3):306-11
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  • Spinal magnetic resonance imaging showed extended intradural, extramedullary, contrast-enhancing masses with compression of the myelon.
  • Spinal leptomeningeal biopsy revealed a pilocytic astrocytoma WHO grade I.
  • Sequence analysis of tumor protein 53 gene (TP53) revealed a missense mutation in exon 5, and expression of phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) protein was not detected, which may have contributed to astrocytoma development.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / genetics. Brain / pathology. Brain / physiopathology. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Mutation / genetics. Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Tumor Suppressor Protein p53 / genetics


17. Huang H, Chen L, Wang H, Xi H, Gou C, Zhang J, Zhang F, Liu Y: Safety of fetal olfactory ensheathing cell transplantation in patients with chronic spinal cord injury. A 38-month follow-up with MRI. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2006 Apr;20(4):439-43
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  • [Title] Safety of fetal olfactory ensheathing cell transplantation in patients with chronic spinal cord injury. A 38-month follow-up with MRI.
  • OBJECTIVE: To determine the safety of the fetal olfactory ensheathing cell (OEC) transplantation in patients with chronic spinal cord injury (SCI) by examination of the magnetic resonance imaging (MRI).
  • The suspension (50 microl) containing about 1 x 10(6) fetal OECs was transplanted by an injection into the patients' spinal cords above and below the injury site.
  • The follow-up with MRI did not reveal any development of optic glial tumor, tumor-like mass, new hemorrhage, edema, expanding cyst, new cyst formation, infection or disruption of the neural structure in the transplant site of all the patients.
  • [MeSH-major] Cell Transplantation. Olfactory Mucosa / cytology. Spinal Cord Injuries / diagnosis. Spinal Cord Injuries / surgery
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Olfactory Bulb / cytology. Olfactory Bulb / transplantation

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  • (PMID = 16683452.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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18. Guo L, Quiñones-Hinojosa A, Yingling CD, Weinstein PR: Continuous EMG recordings and intraoperative electrical stimulation for identification and protection of cervical nerve roots during foraminal tumor surgery. J Spinal Disord Tech; 2006 Feb;19(1):37-42
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  • [Title] Continuous EMG recordings and intraoperative electrical stimulation for identification and protection of cervical nerve roots during foraminal tumor surgery.
  • OBJECTIVE: Spinal cord function is now routinely monitored with somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) during surgery for intraspinal cervical dumbbell and foraminal tumors.
  • Anatomic relations are frequently difficult to interpret because the nerve roots may be displaced by the tumor.
  • A handheld monopolar stimulation electrode was used to elicit evoked EMG responses to identify and trace the course of nerves in relation to the tumor.
  • In four patients, the stimulation threshold was tested before and after tumor resection to predict postoperative nerve root function.
  • RESULTS: Electrical stimulation with CMAP recording was successful in localizing nerve roots during tumor resection in all 10 patients.
  • Monitoring predicted postoperative nerve root preservation after tumor removal in each case.
  • The monitoring of spontaneous muscle activity in response to direct or indirect surgical manipulation during tumor resection also provided continuous assessment of nerve root function and identified any physiologic disturbance induced by surgical manipulation.
  • [MeSH-major] Spinal Neoplasms / surgery. Spinal Nerve Roots
  • [MeSH-minor] Action Potentials. Adolescent. Adult. Cervical Vertebrae. Electric Stimulation. Electromyography. Female. Humans. Intraoperative Period. Male. Middle Aged

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  • (PMID = 16462217.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Tsutsumi S, Nonaka Y, Abe Y, Yasumoto Y, Nakazato Y, Ito M: Intramedullary primitive neuroectodermal tumor presenting with rapidly-progressive cauda equina syndrome. Neurol Med Chir (Tokyo); 2010;50(11):1031-5
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  • [Title] Intramedullary primitive neuroectodermal tumor presenting with rapidly-progressive cauda equina syndrome.
  • Magnetic resonance (MR) imaging revealed a fusiform intramedullary tumor at T12-L1 levels with heterogeneous enhancement.
  • The patient underwent microsurgical tumor resection.
  • A myelotomy exposed a highly vascular tumor that was subtotally resected.
  • Histological examination demonstrated hypercellular tumor accompanied by significant cell atypism and mitotic figures.
  • Immunohistochemical staining was positive for glial fibrillary acidic protein, S-100 protein, synaptophysin, and INI-1, consistent with primitive neuroectodermal tumor (PNET).
  • PNET should be considered in the differential diagnosis of an intramedullary spinal cord tumor.
  • [MeSH-major] Neuroectodermal Tumors, Primitive, Peripheral / pathology. Polyradiculopathy / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Fatal Outcome. Gait Disorders, Neurologic / etiology. Humans. Magnetic Resonance Imaging / methods. Male. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology

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  • (PMID = 21123993.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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20. Makuria AT, Henderson FC, Rushing EJ, Hartmann DP, Azumi N, Ozdemirli M: Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor. J Neurooncol; 2007 Apr;82(2):199-205
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  • [Title] Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor.
  • We report pathologic findings of an unusual spinal cord tumor from a 33-year-old male patient which showed hybrid features of oligodendroglioma and extraventricular neurocytoma.
  • Histologic examination revealed a clear cell neoplasm containing ganglion-like cells and calcifications, prompting the differential diagnosis of oligodendroglioma and extraventricular neurocytoma.
  • The proliferation index (using antibody MIB1) of the tumor was approximately 30%.
  • [MeSH-major] Neurocytoma / pathology. Oligodendroglioma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 17039400.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Sharma MC, Sarkar C, Jain D, Suri V, Garg A, Vaishya S: Uterus-like mass of müllerian origin in the lumbosacral region causing cord tethering. Report of two cases. J Neurosurg Spine; 2007 Jan;6(1):73-6
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  • [Title] Uterus-like mass of müllerian origin in the lumbosacral region causing cord tethering. Report of two cases.
  • Spinal dysraphism, tethered cord syndrome (TCS), and diastematomyelia were also present.
  • [MeSH-major] Lumbosacral Region / pathology. Mixed Tumor, Mullerian / pathology. Neural Tube Defects / complications. Neural Tube Defects / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lipoma / complications. Lipoma / pathology. Lipoma / surgery. Meningomyelocele / complications. Meningomyelocele / pathology. Meningomyelocele / surgery. Skin Neoplasms / complications. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Spinal Dysraphism / complications. Spinal Dysraphism / pathology. Spinal Dysraphism / surgery

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  • (PMID = 17233296.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Jang SY, Kong MH, Song KY, Frazee JG: Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult. J Korean Neurosurg Soc; 2009 Jun;45(6):381-5
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  • [Title] Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult.
  • The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report.
  • Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord.
  • The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II).
  • When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

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  • (PMID = 19609424.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2711238
  • [Keywords] NOTNLM ; Astrocytoma / Cranial metastases / Intramedullary / Spinal cord tumor
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23. Voulgaris S, Alexiou GA, Mihos E, Karagiorgiadis D, Zigouris A, Fotakopoulos G, Drosos D, Pahaturidis D: Posterior approach to ventrally located spinal meningiomas. Eur Spine J; 2010 Jul;19(7):1195-9
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  • [Title] Posterior approach to ventrally located spinal meningiomas.
  • Posterior approach is less invasive and demanding; however, it has been associated with increased risk of spinal cord injury.
  • We evaluated ten consecutive patients that underwent surgery for spinal meningiomas.
  • In nine out of ten cases, the tumor was located in the thoracic spine.
  • After a mean follow-up period of 26 months (range 56-16 months), no tumor recurrence and no instability were found.
  • Complete tumor excision can be performed with satisfactory results.
  • [MeSH-major] Lumbar Vertebrae / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Orthopedic Procedures / methods. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Electromyography. Evoked Potentials, Motor. Evoked Potentials, Somatosensory. Female. Humans. Male. Middle Aged. Monitoring, Intraoperative. Neurologic Examination. Treatment Outcome

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  • (PMID = 20127494.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2900010
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24. Karikari IO, Powers CJ, Bagley CA, Cummings TJ, Radhakrishnan S, Friedman AH: Primary intramedullary melanocytoma of the spinal cord: case report. Neurosurgery; 2009 Apr;64(4):E777-8; discussion E778
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  • [Title] Primary intramedullary melanocytoma of the spinal cord: case report.
  • OBJECTIVE: The authors report 2 cases of primary intramedullary spinal melanocytomas in 2 patients who presented with lower extremity numbness and/or weakness.
  • A review of the relevant literature and clinical behavior of this uncommon tumor entity is provided.
  • [MeSH-major] Melanocytes / pathology. Melanoma. Spinal Cord Neoplasms
  • [MeSH-minor] Adult. Female. Humans. Laminectomy. Magnetic Resonance Imaging / methods. Male. Neurologic Examination. Young Adult

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  • (PMID = 19349809.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Dong LQ, Tian JW, Wang CX, Cao GH: [Surgical treatment for the intradural extramedullary tumor in the spinal canal]. Zhongguo Gu Shang; 2008 Jan;21(1):54-5
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  • [Title] [Surgical treatment for the intradural extramedullary tumor in the spinal canal].
  • OBJECTIVE: To study the clinical characteristics of the intradural extramedullary tumor in the spinal canal, as well as the application of internal fixation technique to restore the spinal stability in the surgical treatment of intradural extramedullary tumor in the spinal canal through posterior approach.
  • METHODS: Among 24 patients receiving the tumor resection through posterior approach, 14 patients were male and 10 patients were female, ranging in age from 12 to 68 years, with an average of 40 years.
  • Fourteen patients were treated with internal fixation and autogenous bone graft after tumor resection, and other 10 patients without internal fixation and autogenous bone graft.
  • RESULTS: All the patients underwent one-stage resection of the tumor.
  • During the follow-up period ranged from 6 months to 3 years (average 22 months), no recurrence of the tumor was found and the injury of spine cord did not aggravate, no vascular or nerve-root injury after the operation.
  • CONCLUSION: After the intradural extramedullary tumor is resected, internal fixation and autogenous bone graft can restore the stability of spine.
  • [MeSH-major] Spinal Canal / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Transplantation. Child. Female. Humans. Internal Fixators. Male. Middle Aged

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  • (PMID = 19102278.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Lepore AC, Neuhuber B, Connors TM, Han SS, Liu Y, Daniels MP, Rao MS, Fischer I: Long-term fate of neural precursor cells following transplantation into developing and adult CNS. Neuroscience; 2006 Sep 29;142(1):287-304
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  • [Title] Long-term fate of neural precursor cells following transplantation into developing and adult CNS.
  • Few studies have examined the long-term properties of transplanted neural precursor cells in the CNS, particularly in non-neurogenic regions of the adult.
  • The aim of the present study was to extensively characterize the fate of defined populations of neural precursor cells following transplantation into the developing and adult CNS (brain and spinal cord) for up to 15 months, including integration of graft-derived neurons with the host.
  • Transplanted cells were prepared from embryonic day-13.5 fetal spinal cord of transgenic donor rats that express the marker gene human placental alkaline phosphatase to achieve stable and reliable graft tracking.
  • We found that in both developing and adult CNS grafted cells showed long-term survival, morphological maturation, extensive distribution and differentiation into all mature CNS cell types (neurons, astrocytes and oligodendrocytes).
  • Graft-derived neurons also formed synapses, as identified by electron microscopy, suggesting that transplanted neural precursor cells integrated with adult CNS.
  • We did not detect tumor formation, cells did not localize to unwanted locations and no pronounced immune response was present at the graft sites.

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  • [RepublishedFrom] Neuroscience. 2006 May 12;139(2):513-30 [16458439.001]
  • (PMID = 17120358.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS 37515; United States / NINDS NIH HHS / NS / NS24707
  • [Publication-type] Comparative Study; Corrected and Republished Article; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gangliosides; 0 / Immunosuppressive Agents; 0 / Nerve Tissue Proteins; 0 / Neural Cell Adhesion Molecules; 0 / ganglioside A2B5
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27. Serarslan Y, Melek IM, Duman T, Eraslan T, Akdemir G, Yalçin F: The co-occurrence of Chiari type 1 malformation with syringomyelia and total situs inversus. Med Sci Monit; 2007 Sep;13(9):CS110-113
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringomyelia (SM) is an uncommon disease of the spinal cord and is known as the occurrence of a cystic space in the middle of the spinal cord.
  • SM occurs due to spinal cord injury, a primary tumor of the spinal cord, or an extramedullary lesion at the foramen magnum such as a Chiari type 1 malformation (CM1).
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Tomography Scanners, X-Ray Computed


28. Selch MT, Lin K, Agazaryan N, Tenn S, Gorgulho A, DeMarco JJ, DeSalles AA: Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors. Surg Neurol; 2009 Dec;72(6):668-74; discussion 674-5
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  • [Title] Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors.
  • A similar approach should be successful for histologically identical spinal nerve sheath tumors.
  • METHODS: The preliminary results of linear accelerator-based spinal radiosurgery were retrospectively reviewed for a group of 25 nerve sheath tumors.
  • Tumor location was cervical 11, lumbar 10, and thoracic 4.
  • Tumor size varied from 0.9 to 4.1 cm (median, 2.1 cm).
  • Tumor size remained stable in 18 cases, and 7 (28%) demonstrated more than 2 mm reduction in tumor size.
  • There has been no clinical or imaging evidence for spinal cord injury.
  • CONCLUSIONS: Results of this limited experience indicate linear accelerator-based spinal radiosurgery is feasible for treatment of benign nerve sheath tumors.
  • Further follow-up is necessary, but our results imply spinal radiosurgery may represent a therapeutic alternative to surgery for nerve sheath tumors.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery. Radiosurgery / instrumentation. Spinal Nerves / surgery. Surgery, Computer-Assisted / instrumentation
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / surgery. Neurologic Examination. Postoperative Complications / diagnosis. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608232.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Deng C, Gorrie C, Hayward I, Elston B, Venn M, Mackay-Sim A, Waite P: Survival and migration of human and rat olfactory ensheathing cells in intact and injured spinal cord. J Neurosci Res; 2006 May 15;83(7):1201-12
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  • [Title] Survival and migration of human and rat olfactory ensheathing cells in intact and injured spinal cord.
  • Increasing evidence indicates the potential of olfactory ensheathing cells (OECs) for treating spinal cord injuries.
  • The present study compared proliferation and migration of adult rat and human OECs transplanted into the spinal cord of athymic (immunodeficient) rats.
  • After OEC injection into the thoracic spinal cord, animals were perfused 4 hr, 24 hr, and 7 days later.
  • Cells were seen leaving the injection site after 4 hr, and by 7 days both rat and human OECs had migrated approximately 1 mm rostrally and caudally within the cord (rat: 1,400 +/- 241 microm rostral, 1,134 +/- 262 microm caudal, n = 5; human: 1,337 +/- 192 microm rostral, 1,205 +/- 148 microm caudal, n = 6).
  • In 10 animals, the spinal cord was injured by a contralateral hemisection made 5 mm rostral to the transplantation site at the time of OEC transplantation.
  • In the injured cord, rat and human OECs migrated for shorter distances, in both rostral and caudal directions (rat: 762 +/- 118 microm rostral, 554 +/- 142 microm caudal, n = 4; human: 430 +/- 55 microm rostral, 399 +/- 161 microm caudal, n = 3).
  • The results show that rat and human OECs rapidly stop dividing after transplantation and have a similar ability to survive and migrate within the spinal cord of immunocompromised hosts.
  • [MeSH-major] Neuroglia / physiology. Olfactory Mucosa / physiology. Spinal Cord / physiology. Spinal Cord Injuries / therapy
  • [MeSH-minor] Animals. Biomarkers / metabolism. Cell Differentiation / physiology. Cell Division / physiology. Cell Movement / physiology. Cell Survival / physiology. Ectodysplasins. Female. Humans. Immunocompromised Host / physiology. Macrophages / cytology. Macrophages / physiology. Male. Membrane Proteins / metabolism. Proliferating Cell Nuclear Antigen / metabolism. Rats. Rats, Nude. Rats, Sprague-Dawley. Tissue Transplantation / methods. Tumor Necrosis Factors / metabolism

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16498634.001).
  • [ISSN] 0360-4012
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / EDA protein, human; 0 / Ectodysplasins; 0 / Membrane Proteins; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Necrosis Factors
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30. Dinomais M, Stana L, Egon G, Richard I, Menei P: Significant recovery of motor function in a patient with complete T7 paraplegia receiving etanercept. J Rehabil Med; 2009 Mar;41(4):286-8
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  • RESULTS: During the first year sensory-motor recovery occurred, and the American Spinal Injury Association Impairment Scale (AIS) improved from A to D.
  • CONCLUSION: Initial spinal cord injury is a direct consequence of the trauma.
  • Tumour necrosis factor alpha is a key inflammatory mediator that is increasingly expressed after spinal cord injury.
  • It has shown an immunomodulatory effect in mice after traumatic spinal cord injury.
  • It significantly reduced the post-traumatic spinal cord inflammation and the perilesional area.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Immunoglobulin G / therapeutic use. Immunologic Factors / therapeutic use. Paraplegia / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use. Spinal Cord Injuries / drug therapy
  • [MeSH-minor] Adult. Etanercept. Female. Humans. Magnetic Resonance Imaging. Neurologic Examination. Recovery of Function. Spinal Cord / pathology. Spinal Cord / radiography. Spondylitis, Ankylosing / drug therapy. Treatment Outcome

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  • (PMID = 19247551.001).
  • [ISSN] 1651-2081
  • [Journal-full-title] Journal of rehabilitation medicine
  • [ISO-abbreviation] J Rehabil Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Immunoglobulin G; 0 / Immunologic Factors; 0 / Receptors, Tumor Necrosis Factor; OP401G7OJC / Etanercept
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31. Clavo B, Robaina F, Catalá L, Lloret M, Pinar B, Caramés MA, Ruiz A, Cabezón A, González G, Lara P, Ruiz-Egea E, Hernández MA: Cerebral blood flow increase in cancer patients by applying cervical spinal cord stimulation. Neurocirugia (Astur); 2007 Feb;18(1):28-32; discussion 33-5
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  • [Title] Cerebral blood flow increase in cancer patients by applying cervical spinal cord stimulation.
  • The aim of this study was to analyze the effect of cervical spinal cord electrical stimulation (cSCS) on cerebral blood flow in patients with those tumors.
  • PATIENTS AND METHODS: We have evaluated 27 cancer patients with 12 with high grade gliomas and 15 with advanced head and neck tumors, who had cSCS devices placed after tumor diagnoses and before the commencement initiating of radio-chemotherapy.
  • RESULTS: During cSCS there was a significant (p<0.001) increase in systolic (mean > 22%) and diastolic (> 29%) blood-flow velocities in both, healthy and tumor middle cerebral arteries.
  • CONCLUSIONS: The results suggest that neuro-stimulation spinal cord electrical stimulation can increase cerebral blood flow in cancer patients.
  • [MeSH-major] Brain Neoplasms / blood supply. Cerebrovascular Circulation. Electric Stimulation Therapy. Glioma / blood supply. Head and Neck Neoplasms / blood supply. Middle Cerebral Artery / physiopathology. Spinal Cord / physiopathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / pharmacokinetics. Blood Flow Velocity. Female. Hemoglobins / analysis. Humans. Male. Middle Aged. Neck. Radiation Tolerance. Research Design. Treatment Outcome. Ultrasonography, Doppler, Transcranial

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  • (PMID = 17393043.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Hemoglobins
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32. Nagarajan R, Mogil R, Neglia JP, Robison LL, Ness KK: Self-reported global function among adult survivors of childhood lower-extremity bone tumors: a report from the Childhood Cancer Survivor Study (CCSS). J Cancer Surviv; 2009 Mar;3(1):59-65
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  • [Title] Self-reported global function among adult survivors of childhood lower-extremity bone tumors: a report from the Childhood Cancer Survivor Study (CCSS).
  • INTRODUCTION: Adult survivors of childhood lower-extremity bone tumors may experience physical and psychosocial late effects that impact physical performance, global function and quality of life.
  • Adult survivors (n = 629) of either childhood onset osteosarcoma or Ewing's sarcoma, with a primary tumor location in the lower-extremity were identified and contacted via mail to complete an additional questionnaire.

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  • [Cites] Med Pediatr Oncol. 2002 Apr;38(4):229-39 [11920786.001]
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  • (PMID = 19030995.001).
  • [ISSN] 1932-2267
  • [Journal-full-title] Journal of cancer survivorship : research and practice
  • [ISO-abbreviation] J Cancer Surviv
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA055727-14; United States / NCI NIH HHS / CA / U24 CA055727; United States / NCI NIH HHS / CA / CA 55727; United States / NCI NIH HHS / CA / U24 CA055727-14
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS91224; NLM/ PMC2657188
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33. Arnold PM, Roh S, Ha TM, Anderson KK: Metastatic synovial sarcoma with cervical spinal cord compression treated with posterior ventral resection: case report. J Spinal Cord Med; 2010;33(1):80-4
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  • [Title] Metastatic synovial sarcoma with cervical spinal cord compression treated with posterior ventral resection: case report.
  • CONTEXT: Synovial sarcomas, which represent 5% to 10% of all adult soft-tissue sarcomas, usually metastasize to the lungs.
  • Spinal cord compression due to spinal metastasis occurs in approximately 3% of patients with extraspinal soft-tissue sarcomas.
  • Magnetic resonance imaging revealed tumor in the posterior elements of C2 and in the ventral epidural space from C2-C5.
  • CONCLUSION AND CLINICAL RELEVANCE: Metastatic spinal cord compression from synovial sarcoma is rare.
  • [MeSH-major] Laminectomy / methods. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / surgery. Spinal Fusion / methods
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Sarcoma, Synovial / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 20397449.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853335
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34. Hamamoto Y, Kataoka M, Senba T, Uwatsu K, Sugawara Y, Inoue T, Sakai S, Aono S, Takahashi T, Oda S: Vertebral metastases with high risk of symptomatic malignant spinal cord compression. Jpn J Clin Oncol; 2009 Jul;39(7):431-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vertebral metastases with high risk of symptomatic malignant spinal cord compression.
  • OBJECTIVE: To find vertebral metastases with high risk of symptomatic malignant spinal cord compression (MSCC), features of vertebral metastases caused motor deficits of the lower extremities were examined.
  • Assessed factors were age, sex, primary disease (lung, breast, digestive system and other cancer), lamina involvement, main level of tumor location and vertebral-body involvement.
  • [MeSH-major] Cervical Vertebrae / pathology. Spinal Cord Compression / etiology. Spinal Neoplasms / secondary. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19429929.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Chen HF, Yang KY, Ju Y, Li GP, Huang SQ: [Clinical analysis of 542 intraspinal tumors microsurgically resected by hemilaminectomy]. Zhonghua Yi Xue Za Zhi; 2010 Apr 6;90(13):874-7
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  • No tumor recurrence was reported in the totally removed cases.
  • The stability of vertebral column was excellent and there was no spinal deformity in these patients.
  • CONCLUSION: With many advantages of minimal trauma, milder postoperative reaction, shorter length of recovery and better spinal stabilization, hemilaminectomy can be used for microsurgical resection of all lateralized epidural, subdural-extramedullary and some benign intramedullary tumors.
  • [MeSH-major] Laminectomy / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Microsurgery. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20646503.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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36. Alkhani A, Blooshi M, Hassounah M: Outcome of surgery for intramedullary spinal ependymoma. Ann Saudi Med; 2008 Mar-Apr;28(2):109-13
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  • [Title] Outcome of surgery for intramedullary spinal ependymoma.
  • BACKGROUND AND OBJECTIVES: Ependymoma is the most frequently encountered intramedullary tumor.
  • This study was designed to define prognostic factors that affect clinical outcome after surgical resection of spinal intramedullary ependymoma.
  • PATIENTS AND METHODS: The medical records, radiological and pathological studies of all patients with intramedullary spinal ependymomas treated surgically in one institution were reviewed retrospectively.
  • Spinal myxopapillary ependymomas were excluded.
  • RESULTS: Surgery was performed on 17 patients (14 males, 3 females, mean age of 42+/-15 years) with spinal ependymoma.
  • The cervical spine was the most common tumor location (71%).
  • Total surgical resection of the tumor was achieved in 11 cases (65%).
  • CONCLUSIONS: Preoperative neurological status was the only statistically significant factor in determining the postoperative neurological outcome of patients with spinal intramedullary ependymomas.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Neoplasm Recurrence, Local / epidemiology. Neurologic Examination. Prognosis. Regression Analysis. Retrospective Studies. Treatment Outcome

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  • (PMID = 18398287.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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37. Manitt C, Wang D, Kennedy TE, Howland DR: Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury. J Neurosci Res; 2006 Dec;84(8):1808-20
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  • [Title] Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury.
  • Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS.
  • To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats.
  • This lesion targets spinal commissural projections, which respond to netrin-1 during development.
  • The dominant expression of UNC5H on axons and neurons in the spinal cord after injury and the persistent expression of netrin-1 by oligodendrocytes surrounding the lesion are consistent with the hypothesis that netrin-1 is a myelin-associated inhibitor of axonal regeneration after spinal cord injury.
  • [MeSH-major] Gene Expression Regulation / physiology. Nerve Growth Factors / metabolism. Receptors, Cell Surface / metabolism. Spinal Cord Injuries / metabolism. Spinal Cord Injuries / physiopathology. Tumor Suppressor Proteins / metabolism

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  • (PMID = 16998900.001).
  • [ISSN] 0360-4012
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Nerve Growth Factors; 0 / Receptors, Cell Surface; 0 / Tumor Suppressor Proteins; 0 / netrin receptors; 158651-98-0 / netrin-1
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38. Barrey C, Kalamarides M, Polivka M, George B: Cervical dumbbell intra-extradural hemangioblastoma: total removal through the lateral approach: technical case report. Neurosurgery; 2005 Mar;56(3):E625; discussion E625
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  • OBJECTIVE AND IMPORTANCE: Extradural hemangioblastomas account for 8 to 12% of all spinal hemangioblastomas.
  • A computed tomographic scan and magnetic resonance imaging demonstrated a dumbbell tumor that had developed through the C5-C6 intervertebral foramen.
  • INTERVENTION: The tumor was totally removed through the lateral approach, with control of the vertebral artery and sacrifice of the C6 cervical nerve root.
  • [MeSH-major] Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Cervical Vertebrae. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Nerve Compression Syndromes / etiology. Spinal Cord Compression / etiology. Spinal Nerve Roots / pathology. Spinal Nerve Roots / surgery. Tomography, X-Ray Computed

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  • (PMID = 15730592.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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39. Song KW, Shin SI, Lee JY, Kim GL, Hyun YS, Park DY: Surgical results of intradural extramedullary tumors. Clin Orthop Surg; 2009 Jun;1(2):74-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Orthopedic Procedures / methods. Young Adult

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  • (PMID = 19885058.001).
  • [ISSN] 2005-4408
  • [Journal-full-title] Clinics in orthopedic surgery
  • [ISO-abbreviation] Clin Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2766757
  • [Keywords] NOTNLM ; Extramedullary / Intradural / Tumor
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40. Baehring JM, Henchcliffe C, Ledezma CJ, Fulbright R, Hochberg FH: Intravascular lymphoma: magnetic resonance imaging correlates of disease dynamics within the central nervous system. J Neurol Neurosurg Psychiatry; 2005 Apr;76(4):540-4
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  • RESULTS: MRI revealed multiple lesions scattered throughout the cerebral hemispheres; the brainstem, cerebellum, and spinal cord were less frequently involved.
  • [MeSH-minor] Adult. Aged. Antigens, CD / immunology. Biopsy. Brain / pathology. Cervical Vertebrae / pathology. Cognition Disorders / diagnosis. Cognition Disorders / etiology. Diagnosis, Differential. Disease Progression. Female. Functional Laterality. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Paraparesis / diagnosis. Paraparesis / etiology. Psychotic Disorders / diagnosis. Psychotic Disorders / etiology. Retrospective Studies. Thoracic Vertebrae / pathology

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  • (PMID = 15774442.001).
  • [ISSN] 0022-3050
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD
  • [Other-IDs] NLM/ PMC1739607
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41. Fernández Carballal C, González Rodrigalvarez R, López De La Riva M, Ares C: Dumbbell-shaped thoracic chondroid chordoma mimicking a neurinoma. Acta Neurochir (Wien); 2010 Feb;152(2):325-6
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  • Magnetic resonance imaging disclosed a homogeneously enhanced mass occupying the spinal canal at the T1-T2 level and extending to the apical pleural space through the right intervertebral foramen.
  • Chondroid chordoma is a subtype of chordomas with better prognosis, and it may appear as a dumbbell-shaped tumor as previously described in classical chordomas.
  • [MeSH-major] Chordoma / pathology. Spinal Canal / surgery. Spinal Cord Compression / surgery. Spinal Neoplasms / pathology. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adult. Decompression, Surgical. Diagnosis, Differential. Female. Humans. Laminectomy. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Radiotherapy / methods. Treatment Outcome. Zygapophyseal Joint / pathology. Zygapophyseal Joint / surgery

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  • (PMID = 19415177.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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42. Donovan DJ, Freeman JH: Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report. Spine (Phila Pa 1976); 2006 Jun 15;31(14):E460-3
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  • [Title] Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report.
  • STUDY DESIGN: We present the case of a patient with a solitary neoplasm of the intramedullary spinal cord.
  • OBJECTIVE: The tumor caused findings of Brown-Séquard syndrome and was the initial presentation of widely metastatic renal cell carcinoma (RCC).
  • SUMMARY OF BACKGROUND DATA: Metastasis of the intramedullary spinal cord has been uncommonly reported and is extremely rare as the initial sign of a disseminated carcinoma.
  • METHODS: The tumor was resected, and the patient's neurologic deficits slowly improved.
  • The histopathology suggested an epithelioid neoplasm.
  • However, despite expert review, the diagnosis was nonspecific, and the tumor appeared benign.
  • RESULTS: It soon recurred in the spinal cord, and repeat imaging studies showed numerous new metastases and a primary renal neoplasm.
  • CONCLUSIONS: Despite being uncommon, spinal cord metastases should be considered in some patients before surgery because it may expedite diagnosis, mitigate the need for surgery, and improve the quality of life for these patients.
  • Clinical factors suggesting metastasis include a personal or family history of malignancy or conditions predisposing to it, the presence of multiple tumors in the spinal cord or elsewhere, nonspecific constitutional symptoms, such as weight loss or decreased appetite, and, specifically for RCC, an abnormally increased hematocrit.
  • [MeSH-major] Brown-Sequard Syndrome / etiology. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16778676.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Rabo CS, Hashimoto N, Kagawa N, Fujita T, Hirayama R, Otsuki H, Kinoshita M, Yoshimine T: A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma. Brain Tumor Pathol; 2010 Oct;27(2):117-20
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  • [Title] A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma.
  • Spinal magnetic resonance imaging (MRI) revealed a solitary, well-defined intramedullary mass at the L1-L2 level typical of a primary spinal cord germinoma.
  • This article describes a rare case of simultaneously detected intracranial and intramedullary spinal cord germinoma and its possible etiopathology.
  • [MeSH-major] Germinoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Fluorodeoxyglucose F18. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Positron-Emission Tomography. Radiopharmaceuticals. Spinal Cord / pathology

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  • (PMID = 21046314.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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44. Salpietro FM, Alafaci C, Collufio D, Lucerna S, Adorno A, Raudino G, Pecora C: Five-level one-piece laminoplasty for extensive tumors of the lumbar spine. J Neurosurg Sci; 2008 Sep;52(3):75-8
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  • The authors describe the surgical method and results of nonexpansive one-piece multivel laminoplasty of the whole lumbar spine, for microsurgical resection of extensive spinal tumors.
  • This technique allows a very comfortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the spinal anatomy.
  • A spinal magnetic resonance imaging (MRI) documented an intradural tumor extending from L2 to S1.
  • The authors believe that multilevel laminoplasty rather than laminectomy is the technique of choice as a posterior procedure for extensive lumbar spinal tumors.
  • With this technique, it is possible to obtain a very confortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the normal spine.
  • [MeSH-major] Ependymoma / surgery. Laminectomy / methods. Lumbar Vertebrae / surgery. Reconstructive Surgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Dura Mater / anatomy & histology. Dura Mater / surgery. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications / prevention & control. Spinal Canal / anatomy & histology. Spinal Canal / surgery. Spinal Cord / pathology. Spinal Cord / surgery. Subarachnoid Space / anatomy & histology. Subarachnoid Space / surgery. Treatment Outcome. Young Adult

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  • (PMID = 18636051.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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45. Schefter TE, Kavanagh BD, Timmerman RD, Cardenes HR, Baron A, Gaspar LE: A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases. Int J Radiat Oncol Biol Phys; 2005 Aug 1;62(5):1371-8
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  • Eligible patients had one to three liver metastases, tumor diameter <6 cm, and adequate liver function.
  • RESULTS: Eighteen patients were enrolled (10 male, 8 female): median age, 55 years (range, 26-83 years); most common primary site, colorectal (6 patients); median aggregate gross tumor volume, 18 ml (range, 3-98 ml).
  • [MeSH-minor] Adult. Aged. Antiemetics / therapeutic use. Cohort Studies. Dose Fractionation. Female. Humans. Kidney. Liver. Male. Maximum Tolerated Dose. Middle Aged. Radiotherapy Planning, Computer-Assisted / methods. Spinal Cord

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  • (PMID = 16029795.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiemetics
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46. Guckenberger M, Baier K, Richter A, Wilbert J, Flentje M: Evolution of surface-based deformable image registration for adaptive radiotherapy of non-small cell lung cancer (NSCLC). Radiat Oncol; 2009;4:68
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  • All CT images were manually [gross tumor volume (GTV)] and automatically [organs-at-risk (OAR) lung, spinal cord, vertebral spine, trachea, aorta, outline] segmented.
  • RESULTS: A progressive tumor shrinkage was observed with median GTV volumes of 170 cm(3) (range 42 cm(3) - 353 cm(3)), 124 cm(3) (19 cm(3) - 325 cm(3)) and 100 cm(3) (10 cm(3) - 270 cm(3)) at treatment planning, mid-way and at the end of treatment.
  • Severe deformation artefacts were observed in patients with resolving atelectasis and pleural effusion, in one patient, where the tumor was located around large bronchi and separate segmentation of the GTV and OARs was not possible, and in one patient, where no clear shrinkage but more a decay of the tumor was observed.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Humans. Middle Aged. Neoplasm Staging. Radiotherapy Planning, Computer-Assisted / methods

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  • (PMID = 20025753.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2804595
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47. Guzel A, Tatli M, Belen D, Seckin H: Spinal cord compression of primary extragonadal giant yolk sac tumor. Spinal Cord; 2007 Mar;45(3):254-7
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  • [Title] Spinal cord compression of primary extragonadal giant yolk sac tumor.
  • OBJECTIVE: To report an adult male patient with a primary extragonadal giant yolk sac tumor presenting with acute spinal cord compression.
  • Posteriorly, the third lumbar vertebral body was destructed and the tumor was compressing the dural sac.
  • Pathological diagnosis was a yolk sac tumor.
  • CONCLUSION: Yolk sac tumor should be considered in young adult male patients presenting with acute paraparesis even without any signs or medical history of a testis tumor.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery. Spinal Cord Compression / surgery
  • [MeSH-minor] Adult. Decompression, Surgical. Humans. Lumbosacral Region / pathology. Lumbosacral Region / surgery. Magnetic Resonance Imaging. Male. Paraparesis / etiology. Tomography, X-Ray Computed

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  • (PMID = 16733519.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Hansen EK, Bucci MK, Quivey JM, Weinberg V, Xia P: Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys; 2006 Feb 1;64(2):355-62
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  • PURPOSE: Many patients with head-and-neck (H&N) cancer have tumor shrinkage and/or weight loss during the course of radiotherapy.
  • Because of tumor shrinkage or weight loss during radiotherapy, a second CT scan was acquired, and a new plan was generated and used to complete the course of IMRT.
  • The doses to 95% (D95) of the planning target volumes of the gross tumor volume (PTVGTV) and the clinical target volume (PTVCTV) were reduced in 92% of patients, by 0.8-6.3 Gy (p=0.02) and 0.2-7.4 Gy (p=0.003), respectively.
  • The maximum dose (Dmax) to the spinal cord increased in all patients (range, 0.2-15.4 Gy; p=0.003) and the brainstem Dmax increased in 85% of patients without replanning (range, 0.6-8.1 Gy; p=0.007).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Brain Stem. Female. Humans. Male. Middle Aged. Nasopharyngeal Neoplasms / radiography. Nasopharyngeal Neoplasms / radiotherapy. Oropharyngeal Neoplasms / radiography. Oropharyngeal Neoplasms / radiotherapy. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Retrospective Studies. Spinal Cord. Statistics, Nonparametric. Weight Loss

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  • (PMID = 16256277.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Tsao YT, Chen WL, Tsai WC: Steroids for acute spinal cord injury: revealing silent pathology. Lancet; 2009 Aug 8;374(9688):500
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  • [Title] Steroids for acute spinal cord injury: revealing silent pathology.
  • [MeSH-major] Glucocorticoids / adverse effects. Lymphoma, Large B-Cell, Diffuse. Methylprednisolone / adverse effects. Spinal Cord Injuries / drug therapy. Tumor Lysis Syndrome / etiology
  • [MeSH-minor] Accidents, Traffic. Acute Disease. Adult. Female. Humans. Whiplash Injuries / complications

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  • (PMID = 19665648.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucocorticoids; X4W7ZR7023 / Methylprednisolone
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50. Girinsky T, Pichenot C, Beaudre A, Ghalibafian M, Lefkopoulos D: Is intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin's disease, and is there a role for beam orientation optimization and dose constraints assigned to virtual volumes? Int J Radiat Oncol Biol Phys; 2006 Jan 1;64(1):218-26
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  • The gross tumor volume was determined according to the prechemotherapy length and the postchemotherapy width of the mediastinal tumor mass.
  • The best compromise in terms of PTV coverage and protection of normal tissues was obtained with five equally spaced beams (5FEQ IMRT plan) using dose constraints assigned to Vvs. When IMRT treatment plans were compared with conventional treatment and 3D-CRT, dose conformation with IMRT was significantly better, with greater protection of the heart, coronary arteries, esophagus, and spinal cord.
  • [MeSH-minor] Adolescent. Adult. Breast. Combined Modality Therapy. Confidence Intervals. Female. Heart. Humans. Lung. Male. Middle Aged. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Radiotherapy, Conformal

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  • (PMID = 16169675.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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51. Sandalcioglu IE, Gasser T, Asgari S, Lazorisak A, Engelhorn T, Egelhof T, Stolke D, Wiedemayer H: Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients. Spinal Cord; 2005 Jan;43(1):34-41
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  • [Title] Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients.
  • OBJECTIVE: To analyze factors with impact on the functional outcome for patients with surgically treated intramedullary spinal cord tumors (IMSCT) and to point out characteristics of the different histological entities.
  • Functional outcome was analyzed depending on histological features, age, tumor localization and the extension of involved spinal segments.
  • Complete tumor removal was achieved in 65 cases (83.3%) and subtotal resection in nine cases.
  • Although there was no outcome difference with respect to the age and tumor extension, thoracically located IMSCTs proved to harbor an increased risk of postoperative surgical morbidity.
  • [MeSH-major] Astrocytoma / surgery. Dermoid Cyst / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Outcome Assessment (Health Care). Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae / surgery. Child. Child, Preschool. Female. Germany. Humans. Infant. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis / pathology. Postoperative Complications / pathology. Postoperative Complications / physiopathology. Prevalence. Risk Factors. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 15326473.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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52. Muñoz E, Prat A, Adamo B, Peralta S, Ramón y Cajal S, Valverde C: A rare case of malignant solitary fibrous tumor of the spinal cord. Spine (Phila Pa 1976); 2008 May 20;33(12):E397-9
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  • [Title] A rare case of malignant solitary fibrous tumor of the spinal cord.
  • OBJECTIVE: We present a case of an ambulatory patient with a solitary fibrous tumor of the spinal cord.
  • SUMMARY OF BACKGROUND DATA: Solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor of the pleural cavity, increasingly recognized at numerous extrathoracic sites, including, among others, prostate, kidney, and thyroid.
  • The spinal cord is an extremely rare localization of SFTs with only 17 cases reported in the literature since 1996.
  • RESULTS: We report the first case of spinal cord SFT with visceral dissemination years after the primary diagnosis, despite benign histologic features of the primary tumor.
  • [MeSH-major] Liver Neoplasms / secondary. Lung Neoplasms / secondary. Solitary Fibrous Tumors / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Antineoplastic Combined Chemotherapy Protocols. Humans. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Male. Orthopedic Procedures. Pneumonectomy. Proto-Oncogene Proteins c-bcl-2 / analysis. Radiotherapy. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Vimentin / analysis

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  • (PMID = 18496336.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Vimentin
  • [Number-of-references] 14
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53. Swanger R, Maldjian C, Murali R, Tenner M: Three cases of benign giant cell tumor with unusual imaging features. Clin Imaging; 2008 Sep-Oct;32(5):407-10
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  • [Title] Three cases of benign giant cell tumor with unusual imaging features.
  • [MeSH-major] Fractures, Spontaneous / diagnosis. Giant Cell Tumor of Bone / diagnosis. Spinal Cord Compression / diagnosis. Spinal Fractures / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Low Back Pain / diagnosis. Low Back Pain / etiology. Magnetic Resonance Imaging / methods. Retrospective Studies. Risk Assessment. Sampling Studies. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 18760733.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Kanno H, Yamamoto I, Nishikawa R, Matsutani M, Wakabayashi T, Yoshida J, Shitara N, Yamasaki I, Shuin T, Clinical VHL Research Group in Japan: Spinal cord hemangioblastomas in von Hippel-Lindau disease. Spinal Cord; 2009 Jun;47(6):447-52
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  • [Title] Spinal cord hemangioblastomas in von Hippel-Lindau disease.
  • OBJECTIVE: To clarify the clinical features and surgical management of spinal cord hemangioblastomas in patients with von Hippel-Lindau disease (VHL).
  • METHODS: Forty-eight out of 66 patients with associated spinal cord hemangioblastoma among 142 VHL patients were retrospectively examined with respect to clinical features, accompanying lesions and outcome of surgical treatment.
  • Twenty-three patients (47.9%) had more than one spinal cord hemangioblastoma.
  • The 48 patients with spinal cord hemangioblastomas collectively had a total of 74 tumors.
  • The tumor was accompanied with a syrinx in 64 and without it in 10 patients.
  • Forty of the 48 patients underwent surgical treatment for their spinal cord hemangioblastomas, and 7 of these 40 underwent surgical treatment twice.
  • CONCLUSION: Von Hippel-Lindau disease patients bearing spinal cord hemangioblastomas mostly had a CNS hemangioblastoma at another site.
  • In these patients, when the timing of treatment for spinal cord hemangioblastoma is determined, the probability of occurrence and treatment of other lesions should be considered.
  • [MeSH-major] Hemangioblastoma / etiology. Hemangioblastoma / surgery. Spinal Cord Neoplasms / etiology. Spinal Cord Neoplasms / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Neurologic Examination. Retrospective Studies. Severity of Illness Index. Treatment Outcome. Young Adult

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  • (PMID = 19030009.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Investigator] Ibayashi Y; Yamaki T; Numagami Y; Jokura E; Kayama Y; Yamada Y; Shiokawa Y; Yamashita J; Hasegawa M; Hatano H; Shinoda J; Sakai N; Taki W; Matsushima S; Murao K; Matsubara T; Takahashi JA; Matsumoto K; Nakajima H; Hashimoto M; Matsumoto S; Ichigizaki K; Murase I; Kashiwabara K; Yamakawa Y; Yamazaki H; Kubo S; Tokuda K; Abiko S; Miyazaki H; Anda T; Shibata S; Miyamoto T; Okawa N; Morimoto S; Inoue M; Miyagami M
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55. Wowra B, Zausinger S, Drexler C, Kufeld M, Muacevic A, Staehler M, Tonn JC: CyberKnife radiosurgery for malignant spinal tumors: characterization of well-suited patients. Spine (Phila Pa 1976); 2008 Dec 15;33(26):2929-34
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  • [Title] CyberKnife radiosurgery for malignant spinal tumors: characterization of well-suited patients.
  • OBJECTIVE: To provide clinical results of CyberKnife fiducial-free spinal radiosurgery.
  • The study focused on patients with no more than 2 malignant spinal tumors.
  • Fiducial-free spinal radiosurgery with the CyberKnife has recently become possible, but until now clinical results obtained with this method had been limited.
  • METHODS: From August 2005 until October 2007, a consecutive series of 102 patients with a total of 134 malignant spinal tumors were selected for single-fraction, fiducial-free CyberKnife radiosurgery (CKRS).
  • Patients with spinal cord compression or evidence of myelopathy were excluded.
  • Tumor-associated spinal pain was prospectively scored according to the visual analogue scale (VAS).
  • Median survival after initial tumor diagnosis was 18.4 years (CI: 15.1-23.4).
  • Two (2%) patients suffered complications after radiosurgery; a tumor hemorrhage occurred in one, and another developed spinal instability.
  • Local tumor control 15 months after CKRS was 98% (95% CI: 89-99%).
  • Tumor-associated pain was observed in 52 (51%) patients.
  • Pain recurrence in correlation with tumor recurrence was observed for 3 (6%) patients.
  • CONCLUSION: Spinal radiosurgery with the CyberKnife technology is a nonivasive, safe, and effective treatment method for patients with 1 or 2 small spinal malignant tumors.
  • The best benefit of the treatment can be expected in patients with good to excellent clinical condition and patients with severe tumor associated pain.
  • [MeSH-major] Patient Selection. Radiosurgery / instrumentation. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pain Measurement / methods. Prospective Studies. Young Adult

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  • (PMID = 19092627.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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56. Duprez TP, Jankovski A, Grandin C, Hermoye L, Cosnard G, Raftopoulos C: Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite. AJNR Am J Neuroradiol; 2008 Nov;29(10):1991-4
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  • [Title] Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite.
  • We assessed feasibility, safety, and timing of an original intraoperative MR procedure in 3 cases of resection of spinal cord glioma by using a clinical 3T MR system connected to an adjacent operating room in a design being coined "twin" or "dual" MR-operating room suite.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Operating Rooms / methods. Operating Rooms / organization & administration. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Belgium. Female. Humans. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 18617591.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Li FM, Luo W, He ZC, Zhang L, Sun Y, Qin WJ, Lu LX, Han F, Liu XQ, Liu MZ: [Dosimetric analysis of radiotherapy with middle shielding blocks of different widths at the lower cervical supraclavicular field for stage N2-3 nasopharyngeal carcinoma]. Ai Zheng; 2007 Oct;26(10):1127-32
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  • There was no significant difference in high dose coverage (V95 and V90) of PTV for the primary gross tumor region (PTVnx), PTV for the cervical metastatic nodes (PTVnd), PTV for the high risk region around primary gross tumor (PTVnx60), PTV for the high risk region around metastatic nodes (PTVnd60), and subclinical lesion region above cricoid cartilage (PTV50b) among the 4 plans.
  • There was no difference in the doses for the spinal cord and larynx among the 4 plans.
  • There were no difference in the doses for the spinal cord and larynx among the 4 plans.
  • [MeSH-minor] Adult. Esophagus / radiation effects. Female. Humans. Lead. Lymph Nodes / radiation effects. Male. Middle Aged. Neck. Neoplasm Staging. Radiotherapy Dosage. Thyroid Gland / radiation effects. Tomography, X-Ray Computed. Trachea / radiation effects

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  • (PMID = 17927886.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 2P299V784P / Lead
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58. Sheil AT, Collins KA: Fatal birth trauma due to an undiagnosed abdominal teratoma: case report and review of the literature. Am J Forensic Med Pathol; 2007 Jun;28(2):121-7
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  • Such injuries include intracranial hemorrhage, spinal cord lesions, cephalhematoma, cranial or peripheral nerve palsies, intraabdominal organ rupture, or bony fractures.
  • The authors present a case of a term gestation neonate who sustained a cervical spine dislocation fracture of C5-7, with subtotal transection of the spinal cord and resultant paralysis.
  • The pathology of teratomas, the most common neonatal tumor and occasionally implicated in cases of birth trauma, will be addressed, followed by a review of the literature concerning birth trauma.
  • [MeSH-minor] Adult. Cervical Vertebrae / injuries. Cesarean Section. Emergencies. Fatal Outcome. Female. Forensic Pathology. Humans. Infant, Newborn. Obstetric Labor Complications / etiology. Paralysis / etiology. Pregnancy. Spinal Cord Injuries / etiology. Spinal Fractures / etiology

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  • (PMID = 17525561.001).
  • [ISSN] 0195-7910
  • [Journal-full-title] The American journal of forensic medicine and pathology
  • [ISO-abbreviation] Am J Forensic Med Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Bi XB, Deng YB, Gan DH, Wang YZ: Salvianolic acid B promotes survival of transplanted mesenchymal stem cells in spinal cord-injured rats. Acta Pharmacol Sin; 2008 Feb;29(2):169-76
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  • [Title] Salvianolic acid B promotes survival of transplanted mesenchymal stem cells in spinal cord-injured rats.
  • AIM: Stem cells hold great promise for brain and spinal cord injuries (SCI), but cell survival following transplantation to adult central nervous system has been poor.
  • CONCLUSION: Sal B provides neuroprotection to SCI and promotes the survival of MSC in vitro and after cell transplantation to the injured spinal cord in vivo.
  • [MeSH-major] Antioxidants / pharmacology. Benzofurans / pharmacology. Mesenchymal Stem Cell Transplantation. Mesenchymal Stromal Cells / drug effects. Spinal Cord Injuries / therapy
  • [MeSH-minor] Animals. Behavior, Animal / physiology. Cell Survival / drug effects. Male. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / pharmacology

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  • (PMID = 18215345.001).
  • [ISSN] 1671-4083
  • [Journal-full-title] Acta pharmacologica Sinica
  • [ISO-abbreviation] Acta Pharmacol. Sin.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Benzofurans; 0 / Tumor Necrosis Factor-alpha; 115939-25-8 / salvianolic acid B
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60. Porensky P, Muro K, Ganju A: Adult presentation of spinal dysraphism and tandem diastematomyelia. Spine J; 2007 Sep-Oct;7(5):622-6
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  • [Title] Adult presentation of spinal dysraphism and tandem diastematomyelia.
  • BACKGROUND CONTEXT: Diastematomyelia is a split-cord malformation often accompanied by other cord or column anomalies.
  • PURPOSE: To report on an adult patient with diastematomyelia and discuss the embryological basis and related developmental sequelae of this split-cord malformation.
  • METHODS: A summary of the management of a 54-year-old woman with recent clinical symptomatology related to an undiagnosed split-cord malformation is presented with accompanying literature review.
  • RESULTS: A rare adult presentation of diastematomyelia with accompanying intradural extramedullary epidermoid tumor was repaired with resection of the soft-tissue mass and excision of the fibro-osseous septum.
  • CONCLUSION: Initial presentation of diastematomyelia is rarely seen in adults; accompanying pathology includes scoliosis, tethered cord, and intradural tumors.
  • [MeSH-major] Epidermal Cyst / radiography. Neural Tube Defects / radiography. Spinal Dysraphism / radiography
  • [MeSH-minor] Age Factors. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Preoperative Care. Spinal Canal / pathology. Spinal Canal / radiography. Tomography, X-Ray Computed

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  • (PMID = 17905326.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Jackson W, Sethi A, Carp J, Talpos G, Vaidya R: Unusual spinal manifestation in secondary hyperparathyroidism: a case report. Spine (Phila Pa 1976); 2007 Sep 1;32(19):E557-60
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  • [Title] Unusual spinal manifestation in secondary hyperparathyroidism: a case report.
  • OBJECTIVES: To describe an unusual spinal manifestation of secondary hyperparathyroidism in a 29-year-old woman and discuss the pathologic basis of the disease and evaluate the response to treatment.
  • Involvement of the cervical spine with this tumor causing neural compression is extremely rare.
  • A cervicothoracic decompression and spinal stabilization from the front and back was performed.
  • An early spinal decompression followed with parathyroidectomy leads to remission of symptoms.
  • [MeSH-major] Calcinosis / diagnosis. Cervical Vertebrae / pathology. Hyperparathyroidism, Secondary / complications. Lumbar Vertebrae / pathology. Spinal Cord Compression / etiology. Spinal Neoplasms / diagnosis. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adult. Decompression, Surgical. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Parathyroidectomy. Spinal Fusion. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17762798.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Rajaram V, Gutmann DH, Prasad SK, Mansur DB, Perry A: Alterations of protein 4.1 family members in ependymomas: a study of 84 cases. Mod Pathol; 2005 Jul;18(7):991-7
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  • Ependymomas are common pediatric and adult CNS malignancies with a wide biologic spectrum that is often hard to predict using classic prognostic variables.
  • The most common genetic alteration has been the loss of the Protein 4.1 family member, NF2, predominantly in spinal ependymomas.
  • These findings prompted us to study Protein 4.1 family members (NF2, 4.1B, 4.1R, 4.1G) in a larger cohort of 84 ependymomas (51 intracranial and 33 spinal; 11 WHO grade I, 43 grade II, 30 grade III).
  • Additionally, frozen tissue from nine ependymomas (four intracranial and five spinal) was obtained for Western blot analysis for merlin, 4.1B and 4.1R expression.
  • The majority of cases harbored one or more detectable genetic alterations, but we found that 4.1B gene deletions and 4.1R loss of expression were statistically more common in the pediatric vs adult, intracranial vs spinal, and grade III vs grade I/II subsets (P-values of 0.038 to <0.001).
  • Also, 4.1G deletions were seen in 11/27 (41%) patients who either died of disease or had residual/recurrent tumor vs 5/41 patients with no evidence of disease at last follow-up (P=0.009).
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Proteins / analysis. Blood Proteins / genetics. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Child. Child, Preschool. Cohort Studies. Cytoskeletal Proteins / analysis. Cytoskeletal Proteins / genetics. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Microfilament Proteins. Microtubule-Associated Proteins / analysis. Microtubule-Associated Proteins / genetics. Middle Aged. Neurofibromin 2 / analysis. Neurofibromin 2 / genetics. Spinal Cord Neoplasms / genetics. Spinal Cord Neoplasms / metabolism. Spinal Cord Neoplasms / pathology. Tumor Suppressor Proteins / analysis. Tumor Suppressor Proteins / genetics

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  • (PMID = 15731777.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Cytoskeletal Proteins; 0 / EPB41L3 protein, human; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / Microtubule-Associated Proteins; 0 / Neurofibromin 2; 0 / Tumor Suppressor Proteins; 0 / erythrocyte membrane band 4.1 protein
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63. Matsuo K, Kakita A, Ishizu N, Endo K, Watanabe Y, Morita T, Takahashi H: Venous congestive myelopathy: three autopsy cases showing a variety of clinicopathologic features. Neuropathology; 2008 Jun;28(3):303-8
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  • We describe three patients with progressive myelopathy, in whom autopsy revealed spinal cord pathology compatible with that of venous congestive myelopathy (VCM) associated with dural arteriovenous fistula (AVF), formerly known as angiodysgenetic necrotizing myelopathy (Foix-Alajournine syndrome).
  • The clinical diagnoses varied and included spinal cord intramedullary tumor, cervical spondylosis and multiple sclerosis.
  • At autopsy, all the patients showed enlarged, tortuous venous vessels on the dorsal surfaces of the spinal cord at the affected levels.
  • In the affected spinal cord parenchyma, necrotic lesions manifested by various degrees of neuronal loss and gliosis, with increased numbers of hyalinized vessels, were evident.
  • The presence or absence of associated spinal dural AVF could not be identified histopathologically.
  • [MeSH-major] Spinal Cord Diseases / pathology. Spinal Cord Diseases / physiopathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Autopsy. Central Nervous System Vascular Malformations / complications. Diagnosis, Differential. Female. Humans. Male. Multiple Sclerosis / pathology. Spinal Cord / blood supply. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology. Spinal Osteophytosis / pathology

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  • (PMID = 18179409.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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64. Amato VG, Assietti R, Morosi M, Arienta C: Acute brainstem dissection of syringomyelia associated with cervical intramedullary neurinoma. Neurosurg Rev; 2005 Apr;28(2):163-7
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  • The acute onset of syringomyelia is most likely attributable to an acute increase in cerebrospinal fluid and epidural venous pressure that results in impulsive fluid movement and, ultimately, in the rupture of the syrinx and dissection into the spinal cord or brainstem.
  • (1) how can a small tumor produce a large syrinx?
  • The authors examined the pathophysiology of syrinx formation and enlargement in intramedullary tumors and reviewed the literature, emphasizing the relationship between spinal cord movements and intramedullary pressure.
  • On the basis of current pathogenetic concepts, the authors concluded that tumor-related syringomyelia might be caused by an association of mechanisms, both from within (obstruction of perivascular spaces; increase in extracellular fluid viscosity due to the tumor itself; intramedullary pressure gradients among different cord levels and between the cord and the subarachnoid space) and from without (the cerebrospinal fluid entering the tissue).
  • All these factors may be amplified, as in the reported case, by a tumor located dorsally at the cervical level.
  • [MeSH-major] Brain Stem. Neurilemmoma / complications. Spinal Cord Neoplasms / complications. Syringomyelia / etiology
  • [MeSH-minor] Acute Disease. Adult. Cervical Vertebrae. Female. Humans. Rupture, Spontaneous / etiology. Rupture, Spontaneous / physiopathology. Rupture, Spontaneous / surgery

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  • (PMID = 15789252.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 41
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65. Rushing EJ, Smith AB, Smirniotopoulos JG, Douglas AF, Zeng W, Azumi N: Occult leptomeningeal large cell medulloblastoma in an adult. Clin Neuropathol; 2009 May-Jun;28(3):188-92
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  • [Title] Occult leptomeningeal large cell medulloblastoma in an adult.
  • We report the first case of this entity in an adult that proved to be an unsuspected primary leptomeningeal tumor.
  • Cervical spine MRI performed the day prior to admission confirmed the diagnosis of Chiari I malformation and C3-4 disk herniation without spinal cord compression.
  • CONCLUSIONS: Our experience with this unique case illustrates the challenges of diagnosing a primary leptomeningeal neoplasm.
  • [MeSH-minor] Adult. Arnold-Chiari Malformation / complications. Fatal Outcome. Humans. Intervertebral Disc Displacement / complications. Magnetic Resonance Imaging. Male

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  • (PMID = 19537136.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Hasegawa M, Fujisawa H, Hayashi Y, Tachibana O, Kida S, Yamashita J: Surgical pathology of spinal schwannoma: has the nerve of its origin been preserved or already degenerated during tumor growth? Clin Neuropathol; 2005 Jan-Feb;24(1):19-25
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  • [Title] Surgical pathology of spinal schwannoma: has the nerve of its origin been preserved or already degenerated during tumor growth?
  • OBJECTIVE: This study was aimed to understand ultrastructural pathology of nerves of tumor origin of spinal schwannomas, which has not been reported so far, in order to understand the mechanism of the postoperative functional restoration after the nerve transection.
  • METHODS: From 13 patients who underwent sacrifice of an affected nerve root at total removal of spinal schwannomas (C2 conus), the proximal (spinal cord side, n = 12) and distal (dorsal root ganglion side, n = 10) stumps of the nerves of the tumor origin were collected and examined by light and electron microscope, followed by morphometric analysis (n = 9).
  • CONCLUSIONS: This data combined with no permanent deficits after nerve transection suggest that the nerves of tumor origin are in the processes of slowly progressed deterioration with repeated degeneration and regeneration/remyelination, and the postoperative rapid recovery from the transient neurological deficit may be explained by functional compensation by the adjacent non-affected nerves with slow tumor growth.
  • [MeSH-major] Nerve Degeneration. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology. Spinal Nerve Roots / pathology. Spinal Nerve Roots / physiopathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Microscopy, Electron. Middle Aged. Myelin Sheath. Nerve Regeneration. Postoperative Period. Recovery of Function

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  • (PMID = 15696780.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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67. Ewelt C, Stummer W, Klink B, Felsberg J, Steiger HJ, Sabel M: Cordectomy as final treatment option for diffuse intramedullary malignant glioma using 5-ALA fluorescence-guided resection. Clin Neurol Neurosurg; 2010 May;112(4):357-61
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  • BACKGROUND: We present a case of an anaplastic astrocytoma (WHO-grade III, AA III) in a 27-year-old woman treated by spinal cordectomy.
  • To assess tumor invasion intraoperatively, we used tumor fluorescence derived from 5-aminolevulinic acid (5-ALA).
  • PATIENTS COURSE: The spinal cord was amputated caudally to the root entry zones of the T10 sensory roots.
  • Additional cordectomy was performed because of tumor infiltration at the cut end to T9 as identified by intraoperative tumor fluorescence, and as verified histologically.
  • The final transected level was between T8 and T9, and the cut end did not reveal any tumor invasion intraoperatively by tumor fluorescence and postoperatively by MRI and with regard to the pathological result.
  • CONCLUSION: Our observation suggests 5-ALA fluorescence-guided resections to be useful in the context of malignant spinal cord gliomas.
  • Furthermore, our particular case indicates that palliative spinal cordectomy with a wide margin and intraoperative resection using fluorescence guidance may be a final option for patients with recurrent spinal malignant glioma presenting with complete deficit below the lesion.
  • [MeSH-major] Aminolevulinic Acid. Astrocytoma / surgery. Cordotomy / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Pain / drug therapy. Pain / etiology. Paraplegia / etiology. Spine / pathology

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20061079.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 88755TAZ87 / Aminolevulinic Acid
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68. Bohl D, Liu S, Blanchard S, Hocquemiller M, Haase G, Heard JM: Directed evolution of motor neurons from genetically engineered neural precursors. Stem Cells; 2008 Oct;26(10):2564-75
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  • Stem cell-based therapies hold therapeutic promise for degenerative motor neuron diseases, such as amyotrophic lateral sclerosis, and for spinal cord injury.
  • Fetal neural progenitors present less risk of tumor formation than embryonic stem cells but inefficiently differentiate into motor neurons, in line with their low expression of motor neuron-specific transcription factors and poor response to soluble external factors.
  • To overcome this limitation, we genetically engineered fetal rat spinal cord neurospheres to express the transcription factors HB9, Nkx6.1, and Neurogenin2.
  • When transplanted in the injured adult rat spinal cord, a model of acute motor neuron degeneration, the engineered precursors transiently proliferated, colonized the ventral horn, expressed motor neuron-specific differentiation markers, and projected cholinergic axons in the ventral root.
  • We conclude that genetic engineering can drive the differentiation of fetal neural precursors into motor neurons that efficiently engraft in the spinal cord.
  • [MeSH-minor] Animals. Axons / metabolism. Biomarkers / metabolism. Cell Communication. Cell Differentiation. Cell Movement. Choline / metabolism. Coculture Techniques. Humans. Mice. Muscle Fibers, Skeletal / cytology. Muscle Fibers, Skeletal / metabolism. Organ Specificity. Rats. Spinal Cord Injuries / pathology. Spinal Nerve Roots / pathology. Stem Cell Transplantation. Transcription Factors / metabolism

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  • (PMID = 18635866.001).
  • [ISSN] 1549-4918
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Transcription Factors; N91BDP6H0X / Choline
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69. MacDonald TJ, Arenson EB, Ater J, Sposto R, Bevan HE, Bruner J, Deutsch M, Kurczynski E, Luerssen T, McGuire-Cullen P, O'Brien R, Shah N, Steinbok P, Strain J, Thomson J, Holmes E, Vezina G, Yates A, Phillips P, Packer R: Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933. Cancer; 2005 Dec 15;104(12):2862-71
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  • The authors conclude that these commonly used HDCT regimens provide no additional clinical benefit to conventional treatment in HGA, regardless of the amount of measurable residual tumor.
  • [MeSH-minor] Adolescent. Adult. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / radiotherapy. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Humans. Male. Neoplasm Staging. Probability. Prognosis. Prospective Studies. Radiotherapy, High-Energy. Reference Values. Risk Assessment. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiotherapy. Survival Analysis. Time Factors. Treatment Outcome

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16315242.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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70. Kashiwazaki D, Hida K, Yano S, Seki T, Iwasaki Y: Subpial hemangiopericytoma with marked extramedullary growth: case report. Neurosurgery; 2007 Dec;61(6):E1336-7; discussion E1337
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  • Central nervous system hemangiopericytomas occur primarily in the epidural space of the brain and spinal cord.
  • INTERVENTION: Magnetic resonance imaging revealed an intradural tumor at the T4-T6 level of the thoracic spine.
  • Because the patient's symptoms progressed, he underwent resection of the tumor, which had arisen in the spinal cord subpially without attachment to the dura mater.
  • Differential diagnoses include hemangioblastoma, meningioma, schwannoma, and solitary fibrous tumor, the clinical course and prognosis of which are different from hemangiopericytoma.
  • [MeSH-major] Dura Mater / pathology. Hemangiopericytoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Disease Progression. Humans. Magnetic Resonance Imaging / methods. Male

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  • (PMID = 18162866.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Vadikolias K, Kouklakis G, Heliopoulos I, Argyropoulou P, Papanas N, Tzilonidou M, Prassopoulos P, Piperidou H: Acute paraplegia after the initiation of anti-tumour necrosis factor-alpha therapy for Crohn's disease. Eur J Gastroenterol Hepatol; 2007 Feb;19(2):159-62
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  • Two months later, no abnormal signal intensity was observed in the spinal cord and after 4 months, the patient presented improvement of motor function.
  • [MeSH-major] Antibodies, Monoclonal / adverse effects. Crohn Disease / drug therapy. Gastrointestinal Agents / adverse effects. Paraplegia / chemically induced. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Acute Disease. Adult. Humans. Infliximab. Magnetic Resonance Imaging. Male. Myelitis / chemically induced. Myelitis / diagnosis

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  • (PMID = 17273002.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Gastrointestinal Agents; 0 / Tumor Necrosis Factor-alpha; B72HH48FLU / Infliximab
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72. Deniaud-Alexandre E, Touboul E, Lerouge D, Grahek D, Foulquier JN, Petegnief Y, Grès B, El Balaa H, Keraudy K, Kerrou K, Montravers F, Milleron B, Lebeau B, Talbot JN: [Impact of computed tomography (CT) and 18F-deoxyglucose-coincidence detection emission tomography (FDG-CDET) image fusion for optimisation of conformal radiotherapy in non-small-cell lung cancers]. Cancer Radiother; 2005 Sep;9(5):304-15
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  • The gross tumor volume (GTV) was decreased by CT/PET image fusion in 21 patients (23%) and was increased in 24 patients (26%).
  • The spinal cord volume receiving at least 45 Gy (2 patients) decreased.
  • After multivariate analysis, one single independent factor made significant effect of FDG/PET on the modification of the size of the GTV: tumor with atelectasis (P = 0.0001).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Pulmonary Atelectasis / pathology. Radiopharmaceuticals. Radiotherapy Dosage. Retrospective Studies

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  • (PMID = 16087377.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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73. Ohtonari T, Nishihara N, Ota T, Ota S, Koyama T: Intramedullary schwannoma of the conus medullaris complicated by dense adhesion to neural tissue. Neurol Med Chir (Tokyo); 2009 Nov;49(11):536-8
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  • Subtotal removal of the lesion was achieved, as part of the tumor showed dense adhesion to the rostral neural tissue, with only postoperative transient deterioration of bladder dysfunction.
  • Intramedullary schwannoma, especially involving the conus medullaris and the proximal spinal cord, is relatively rare and the pathogenesis and pathophysiology are unclear.
  • Complete resection is often advised to avoid recurrence, but tumor adhesion to neural tissue sometimes renders complete resection difficult, and may create the risk of unacceptable operative morbidity.
  • [MeSH-major] Neurilemmoma / pathology. Spinal Cord / pathology. Spinal Cord Compression / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Decompression, Surgical. Disease Progression. Erectile Dysfunction / etiology. Humans. Laminectomy. Lumbar Vertebrae / pathology. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neurosurgical Procedures. Paresthesia / etiology. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Spinal Canal / pathology. Spinal Canal / surgery. Treatment Outcome. Urinary Bladder, Neurogenic / etiology

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  • (PMID = 19940405.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Kurokawa R, Kawase T: Spinal arachnoid cyst causing paraplegia following skull base surgery. Neurol Med Chir (Tokyo); 2006 Jun;46(6):309-12
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  • [Title] Spinal arachnoid cyst causing paraplegia following skull base surgery.
  • The patient underwent subtotal removal of the tumor via an anterior transpetrosal approach.
  • Preexisting long-tract signs and coincidental hydrocephalus confused the neurological findings and delayed detection of the spinal lesion in this case.
  • Neurosurgeons should be alert to the possibilities of insidious spinal lesion if the patient has progressive neurological disorder which does not match the known cranial lesion.
  • [MeSH-major] Arachnoid Cysts / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Postoperative Complications / surgery. Spinal Cord Compression / surgery
  • [MeSH-minor] Adult. Cerebrospinal Fluid Shunts. Decompression, Surgical. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hydrocephalus / diagnosis. Hydrocephalus / surgery. Laminectomy. Magnetic Resonance Imaging. Neoplasm, Residual / diagnosis. Neurologic Examination. Recurrence. Reoperation. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery

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  • (PMID = 16794354.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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75. Kinoshita Y, Akatsuka K, Ohtake M, Kamitani H, Watanabe T: Primary intramedullary spinal cord germinoma. Neurol Med Chir (Tokyo); 2010;50(7):592-4
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  • [Title] Primary intramedullary spinal cord germinoma.
  • A 21-year-old woman presented with an intramedullary spinal cord germinoma and a history of gait disturbance and elimination disorder.
  • After partial reduction of the intramedullary mass, histological findings revealed that the tumor was typical germinoma.
  • No recurrence of the tumor has been detected 3 years after the operation, and no dissemination into the cranial area was detected.
  • Cisplatin and etoposide chemotherapy combined with radiotherapy is recommended for primary spinal germinoma, and is effective for inhibition of both tumor dissemination and recurrence.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Lumbar Vertebrae. Radiotherapy, Adjuvant. Spinal Cord / pathology. Spinal Cord / surgery. Thoracic Vertebrae. Young Adult

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  • (PMID = 20671389.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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76. Shono T, Natori Y, Morioka T, Torisu R, Mizoguchi M, Nagata S, Suzuki SO, Iwaki T, Inamura T, Fukui M, Oka K, Sasaki T: Results of a long-term follow-up after neuroendoscopic biopsy procedure and third ventriculostomy in patients with intracranial germinomas. J Neurosurg; 2007 Sep;107(3 Suppl):193-8
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  • All patients received chemotherapy and radiotherapy postoperatively, according to the regimen promulgated by the Japanese Pediatric Brain Tumor Study Group.
  • Only one patient had a recurrent lesion in the spinal cord 6 years after the initial treatment; however, this patient had undergone only the neuroendoscopic biopsy procedure without ETV.
  • The risk of tumor dissemination due to the neuroendoscopic procedures appears to be minimal when the appropriate chemotherapy and radiotherapy are provided postoperatively.
  • [MeSH-minor] Adolescent. Adult. Biopsy. Combined Modality Therapy. Endoscopy. Female. Follow-Up Studies. Humans. Hydrocephalus / pathology. Hydrocephalus / surgery. Magnetic Resonance Imaging. Male. Neoplasm Seeding. Postoperative Complications. Retrospective Studies. Third Ventricle / pathology. Third Ventricle / surgery. Treatment Outcome

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  • (PMID = 17918523.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Pizzi MA, Crowe MJ: Transplantation of fibroblasts that overexpress matrix metalloproteinase-3 into the site of spinal cord injury in rats. J Neurotrauma; 2006 Dec;23(12):1750-65
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  • [Title] Transplantation of fibroblasts that overexpress matrix metalloproteinase-3 into the site of spinal cord injury in rats.
  • Growth-inhibitory chondroitin sulfate proteoglycans (CSPGs) are upregulated during glial scar formation at the site of spinal cord injury (SCI) in adult mammals.
  • Increased MMP synthesis and secretion are observed in fibroblasts adjacent to tumor cells that express the protein EMMPRIN (Extracellular Matrix MetalloPRoteinase INducer).
  • Decreased CSPG immunoreactivity was observed in injured spinal cord sections when they were incubated with media from EMMPRIN-transduced fibroblasts.
  • EMMPRIN, and consequently MMP, delivery to the injured spinal cord may prove to be beneficial in reducing some of the physical barriers to axonal growth after SCI.
  • [MeSH-major] Antigens, CD147 / administration & dosage. Fibroblasts / transplantation. Spinal Cord Injuries / therapy

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  • (PMID = 17184186.001).
  • [ISSN] 0897-7151
  • [Journal-full-title] Journal of neurotrauma
  • [ISO-abbreviation] J. Neurotrauma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 136894-56-9 / Antigens, CD147; EC 3.4.24.17 / Matrix Metalloproteinase 3
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78. Atkin N, Jackson KA, Danks RA: Bilateral open thoracic cordotomy for refractory cancer pain: a neglected technique? J Pain Symptom Manage; 2010 May;39(5):924-9
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  • Of these techniques, spinal analgesia is most commonly used in Australia and the United Kingdom, and neurosurgical procedures, such as open cordotomy with sectioning of the spinothalamic tract, are rarely used.
  • We describe a case illustrating the successful use of bilateral open thoracic cordotomy in a patient with refractory mixed nociceptive and neuropathic pain secondary to a lumbosacral tumor.
  • [MeSH-major] Cordotomy. Neurofibroma, Plexiform / complications. Pain, Intractable / surgery. Spinal Cord Neoplasms / complications
  • [MeSH-minor] Humans. Male. Thoracic Vertebrae / surgery. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20471552.001).
  • [ISSN] 1873-6513
  • [Journal-full-title] Journal of pain and symptom management
  • [ISO-abbreviation] J Pain Symptom Manage
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Bagley CA, Wilson S, Kothbauer KF, Bookland MJ, Epstein F, Jallo GI: Long term outcomes following surgical resection of myxopapillary ependymomas. Neurosurg Rev; 2009 Jul;32(3):321-34; discussion 334
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  • Myxopapillary ependymomas, a specific tumor variant of spinal cord ependymomas, occur most commonly in the lumbosacral region.
  • During the study period, 1,013 patients underwent surgery for spinal cord tumors.
  • The adult mean age was 38.7 years.
  • Overall, the pediatric patients had a much more aggressive clinical course with a much higher rate of local recurrence and dissemination of the tumor within the neural axis (64% versus 32%).
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Arthritis, Experimental / etiology. Arthritis, Experimental / pathology. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Postoperative Complications / epidemiology. Postoperative Complications / pathology. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19221818.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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80. Mobley B, Kalani MY, Harsh GR 4th, Edwards MS, Vogel H: Papillary tumor of the spinal cord: report of 2 cases. Am J Surg Pathol; 2009 Aug;33(8):1191-7
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  • [Title] Papillary tumor of the spinal cord: report of 2 cases.
  • Intramedullary spinal cord tumors constitute a small fraction of central nervous system tumors in the pediatric population; of these, the majority are ependymomas or astrocytomas.
  • We report 2 pediatric spinal cord tumor cases with unique morphologic and immunohistochemical features.
  • The first patient presented at age 7 with an intramedullary tumor of the thoracic spine.
  • The second patient presented at age 17 with an intramedullary tumor of the cervical spine.
  • The tumor recurred locally and in the cerebellum.
  • The clinical features, including propensity for recurrence and remote subarachnoid spread, and the pathologic features of these tumors are reminiscent of papillary tumor of the pineal region, ependymoma, and choroid plexus papilloma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Male. Neurosurgical Procedures. Radiotherapy

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  • (PMID = 19417584.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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81. Küsters-Vandevelde HV, Klaasen A, Küsters B, Groenen PJ, van Engen-van Grunsven IA, van Dijk MR, Reifenberger G, Wesseling P, Blokx WA: Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system. Acta Neuropathol; 2010 Mar;119(3):317-23
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  • These GNAQ-mutated tumors were predominantly located around the spinal cord (6/7).
  • One melanoma carried a BRAF point mutation that is frequently found in cutaneous melanomas (c.1799 T>A, p.V600E), raising the question whether this is a metastatic rather than a primary tumor.
  • [MeSH-minor] Adult. Aged. Codon / genetics. DNA, Neoplasm / genetics. DNA, Neoplasm / isolation & purification. Female. Genes, ras / genetics. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Proto-Oncogene Proteins B-raf / genetics. Retrospective Studies. Tissue Fixation

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  • (PMID = 19936769.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Codon; 0 / DNA, Neoplasm; 0 / GNAQ protein, human; 0 / GTP-Binding Protein alpha Subunits; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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82. Yao KC, McGirt MJ, Chaichana KL, Constantini S, Jallo GI: Risk factors for progressive spinal deformity following resection of intramedullary spinal cord tumors in children: an analysis of 161 consecutive cases. J Neurosurg; 2007 Dec;107(6 Suppl):463-8
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  • [Title] Risk factors for progressive spinal deformity following resection of intramedullary spinal cord tumors in children: an analysis of 161 consecutive cases.
  • OBJECT: Gross-total resection of pediatric intramedullary spinal cord tumors (IMSCTs) can be achieved in the majority of cases, with preservation of long-term neurological function.
  • However, progressive spinal deformity requiring subsequent fusion occurs in many cases.
  • It remains unknown which subgroups of patients have the greatest risk for progressive spinal deformity.
  • METHODS: Data for 161 patients undergoing resection of IMSCTs at a single institution were retrospectively collected and analyzed with regard to the development of progressive spinal deformity requiring fusion and patient functional status (based on the modified McCormick Scale [mMS] and Karnofsky Performance Scale [KPS]) by conducting telephone interviews corroborated by medical records.
  • The independent association of all clinical, radiographic, and operative variables to subsequent progressive spinal deformity was assessed using multivariate logistic regression analysis.
  • The tumor spanned a mean of six +/- three spinal levels.
  • A median of 9 years (range 1-21) after surgery, progressive spinal deformity requiring fusion developed in 43 patients (27%).
  • An age less than 13 years, preoperative scoliotic deformity (Cobb angle > 10 degrees), involvement of the thoracolumbar junction, and tumor-associated syrinx independently increased the odds of a postoperative progressive deformity requiring fusion 4.4-, 3.2-, 2.6-, and 3.4-fold, respectively (p < 0.05).
  • Symptoms lasting less than 1 month before resection decreased the odds of spinal deformity requiring fusion ninefold (p < 0.05).
  • CONCLUSIONS: Progressive spinal deformity requiring fusion occurred in 27% of children undergoing resection of an IMSCT and was associated with a decreased functional status.
  • Preoperative scoliotic deformity, an increasing number of resections, an age less than 13 years, tumor-associated syrinx, and surgery spanning the thoracolumbar junction increased the risk for progressive spinal deformity.
  • Patients possessing one or more of these characteristics should be monitored closely for progressive spinal deformity following surgery.
  • [MeSH-major] Neurosurgical Procedures / adverse effects. Postoperative Complications / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / surgery. Spinal Diseases / etiology
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Child. Child, Preschool. Disease Progression. Female. Humans. Infant. Laminectomy. Logistic Models. Male. Prognosis. Reoperation. Retrospective Studies. Risk Factors. Spinal Fusion

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  • [CommentIn] J Neurosurg. 2007 Dec;107(6 Suppl):460-2; discussion 462 [18154013.001]
  • (PMID = 18154014.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Yoon SH, Shim YS, Park YH, Chung JK, Nam JH, Kim MO, Park HC, Park SR, Min BH, Kim EY, Choi BH, Park H, Ha Y: Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells; 2007 Aug;25(8):2066-73
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  • [Title] Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial.
  • To assess the safety and therapeutic efficacy of autologous human bone marrow cell (BMC) transplantation and the administration of granulocyte macrophage-colony stimulating factor (GM-CSF), a phase I/II open-label and nonrandomized study was conducted on 35 complete spinal cord injury patients.
  • The BMCs were transplanted by injection into the surrounding area of the spinal cord injury site within 14 injury days (n = 17), between 14 days and 8 weeks (n = 6), and at more than 8 weeks (n = 12) after injury.
  • The patients underwent preoperative and follow-up neurological assessment using the American Spinal Injury Association Impairment Scale (AIS), electrophysiological monitoring, and magnetic resonance imaging (MRI).
  • At 4 months, the MRI analysis showed the enlargement of spinal cords and the small enhancement of the cell implantation sites, which were not any adverse lesions such as malignant transformation, hemorrhage, new cysts, or infections.
  • Increasing neuropathic pain during the treatment and tumor formation at the site of transplantation are still remaining to be investigated.
  • [MeSH-major] Bone Marrow Cells / drug effects. Bone Marrow Transplantation / methods. Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use. Spinal Cord Injuries / therapy. Transplantation Conditioning / methods
  • [MeSH-minor] Adolescent. Adult. Algorithms. Cervical Vertebrae. Female. Follow-Up Studies. Humans. Leukocytes / cytology. Leukocytes / drug effects. Leukocytosis / blood. Leukocytosis / etiology. Male. Middle Aged. Models, Biological. Pain Measurement. Transplantation, Autologous


84. Wu B, You C, Cai BW, He M, Shuai KG: [Therapeutic effect of far lateral approach on the lesions located ventral to cranial-cervical junction]. Zhonghua Wai Ke Za Zhi; 2005 May 1;43(9):612-5
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  • OBJECTIVE: To investigate the administration of far-lateral approach in lesions located anterior or anterolateral to brain stem and upper cervical spinal cord.
  • RESULTS: Total tumor removal was achieved in 15 patients, subtotal removal in 5 patients, 3 vertibral artery aneurysms were clipped successfully, 3 patients were given occipitalcervical fusion.
  • The most frequent complications were lower cranial nerve deficit, CSF leakage, injury to vertibral artery, and ischemia of brain stem, cerebellum or spinal cord.
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Male. Microsurgery. Middle Aged. Treatment Outcome

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  • (PMID = 15938939.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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85. Bhatia K, Frydenberg E, Steel T, Ow-Yang M, Ho K, Grainger E: Spinal epidural lipomatosis due to a bronchial ACTH-secreting carcinoid tumour. J Clin Neurosci; 2010 Nov;17(11):1461-2
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  • [Title] Spinal epidural lipomatosis due to a bronchial ACTH-secreting carcinoid tumour.
  • Spinal epidural lipomatosis (SEL) is a rare condition characterized by abnormal deposits of fat in the epidural space.
  • Our patient was a 34-year-old Caucasian male farm worker presenting with acute spinal cord compression.
  • MRI demonstrated posterior epidural lipomatosis, with cord compression from T3 to T8.
  • Urgent spinal cord decompression was performed.
  • [MeSH-major] Adrenocorticotropic Hormone / blood. Carcinoid Tumor / complications. Cushing Syndrome / etiology. Lipomatosis / etiology. Lung Neoplasms / complications. Spinal Cord Compression / etiology
  • [MeSH-minor] Adult. Humans. Male. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20709555.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
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86. Rosemberg S, Fujiwara D: Epidemiology of pediatric tumors of the nervous system according to the WHO 2000 classification: a report of 1,195 cases from a single institution. Childs Nerv Syst; 2005 Nov;21(11):940-4
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  • In the whole series, 58.7% were supratentorial, 31.4% infratentorial, and 9.9% spinal (44% intra- and 56% extramedullary).
  • [MeSH-major] Brain Neoplasms / epidemiology. Spinal Cord Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Brain / pathology. Brazil / epidemiology. Child. Child, Preschool. Cross-Sectional Studies. Female. Humans. Incidence. Infant. Male. Sex Factors. Spinal Cord / pathology. World Health Organization

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  • (PMID = 16044344.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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87. Zhang WD, Xie CM, Mo YX, Li JY: [CT and MRI features of peripheral primitive neuroectodermal tumor]. Ai Zheng; 2007 Jun;26(6):643-6
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  • [Title] [CT and MRI features of peripheral primitive neuroectodermal tumor].
  • BACKGROUND & OBJECTIVE: It's difficult to distinguish peripheral primitive neuroectodermal tumor (PNET) from other small round cell tumors such as Ewing's sarcoma by histological examination.
  • RESULTS: The tumors were located in the left ala nasi, right lower jaw bone, left chest wall, right chest wall, left spermatic cord, paraspinal, and lumbar vertebral canal.
  • The tumors in the paraspinal and vertebral canal showed well-defined soft tissue masses without involving cord and cauda equine on MRI, and showed isointensity or hypointensity on T1WI and isointensity or hyperintensity on T2WI.
  • [MeSH-major] Jaw Neoplasms / radiography. Neuroectodermal Tumors, Primitive, Peripheral / diagnosis. Neuroectodermal Tumors, Primitive, Peripheral / radiography. Spinal Neoplasms / diagnosis. Thoracic Neoplasms / radiography
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Genital Neoplasms, Male / radiography. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Retrospective Studies. Spermatic Cord / radiography. Spinal Canal. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 17562273.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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88. Tan AM, Colletti M, Rorai AT, Skene JH, Levine JM: Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. J Neurosci; 2006 May 3;26(18):4729-39
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  • [Title] Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord.
  • To determine the functions of NG2, we infused mixtures of neutralizing or non-neutralizing anti-NG2 monoclonal antibodies into the dorsally transected adult rat spinal cord and analyzed the regeneration of ascending mechanosensory axons anatomically.
  • The low intrinsic growth capacity of adult neurons may also limit the ability of damaged axons to regenerate.
  • These axons did not grow past the rostral border of the lesion; rather, they grew along the dorsal surface of the spinal cord and within any remaining pieces of the dorsal roots.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antigens / immunology. Axons / drug effects. Nerve Regeneration / drug effects. Neurons, Afferent / pathology. Proteoglycans / immunology. Spinal Cord Injuries / drug therapy
  • [MeSH-minor] Analysis of Variance. Animals. Antigens, CD11b / metabolism. Blotting, Western / methods. Disease Models, Animal. Ectodysplasins. Female. Fibronectins / metabolism. Fluorescent Antibody Technique / methods. Glial Fibrillary Acidic Protein / metabolism. Immunoprecipitation / methods. Laminectomy / methods. Membrane Proteins / metabolism. Myelin Proteins / metabolism. Neuroglia / drug effects. Neuroglia / pathology. Peripheral Nervous System Diseases / drug therapy. Peripheral Nervous System Diseases / pathology. Rats. Rats, Sprague-Dawley. Time Factors. Tumor Necrosis Factors / metabolism

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  • (PMID = 16672645.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens; 0 / Antigens, CD11b; 0 / Ectodysplasins; 0 / Fibronectins; 0 / Glial Fibrillary Acidic Protein; 0 / Membrane Proteins; 0 / Myelin Proteins; 0 / Nogo protein; 0 / Proteoglycans; 0 / Tumor Necrosis Factors; 0 / chondroitin sulfate proteoglycan 4
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89. Tschernatsch M, Dierkes C, Gerriets T, Hosch J, Stolz E, Kaps M, Krasenbrink I, Claus D, Blaes F: Paraneoplastic neurological syndromes in patients with carcinoid. Eur J Neurol; 2008 Dec;15(12):1390-4
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  • [MeSH-major] Carcinoid Tumor / complications. Paraneoplastic Syndromes / etiology
  • [MeSH-minor] Aged. Autoantibodies / immunology. Biomarkers / analysis. Biomarkers / metabolism. ELAV Proteins / immunology. Encephalitis / etiology. Encephalitis / pathology. Encephalitis / physiopathology. Female. Humans. Limbic Encephalitis / pathology. Limbic Encephalitis / physiopathology. Male. Middle Aged. Nerve Tissue Proteins / immunology. Paraneoplastic Polyneuropathy / pathology. Paraneoplastic Polyneuropathy / physiopathology. Spinal Cord Diseases / etiology. Spinal Cord Diseases / pathology. Spinal Cord Diseases / physiopathology. Young Adult

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  • (PMID = 19049559.001).
  • [ISSN] 1468-1331
  • [Journal-full-title] European journal of neurology
  • [ISO-abbreviation] Eur. J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Biomarkers; 0 / CDR2 protein, human; 0 / ELAV Proteins; 0 / Nerve Tissue Proteins
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90. Dodd RL, Ryu MR, Kamnerdsupaphon P, Gibbs IC, Chang SD Jr, Adler JR Jr: CyberKnife radiosurgery for benign intradural extramedullary spinal tumors. Neurosurgery; 2006 Apr;58(4):674-85; discussion 674-85
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  • [Title] CyberKnife radiosurgery for benign intradural extramedullary spinal tumors.
  • OBJECTIVE: Microsurgical resection of benign intradural extramedullary spinal tumors is generally safe and successful, but patients with neurofibromatosis, recurrent tumors, multiple lesions, or medical problems that place them at higher surgical risk may benefit from alternatives to surgery.
  • In this prospective study, we analyzed our preliminary experience with image-guided radiosurgical ablation of selected benign spinal neoplasms.
  • METHODS: Since 1999, CyberKnife (Accuray, Inc., Sunnyvale, CA) radiosurgery was used to manage 51 patients (median age, 46 yr; range, 12-86 yr) with 55 benign spinal tumors (30 schwannomas, nine neurofibromas, 16 meningiomas) at Stanford University Medical Center.
  • Total treatment doses ranged from 1600 to 3000 cGy delivered in consecutive daily sessions (1-5) to tumor volumes that varied from 0.136 to 24.6 cm.
  • RESULTS: Less than 1 year postradiosurgery, three of the 51 patients in this series (one meningioma, one schwannoma, and one neurofibroma) required surgical resection of their tumor because of persistent or worsening symptoms; only one of these lesions was larger radiographically.
  • CONCLUSION: Although more patients studied over an even longer follow-up period are needed to determine the long-term efficacy of spinal radiosurgery for benign extra-axial neoplasms, short-term clinical benefits were observed in this prospective analysis.
  • [MeSH-major] Radiosurgery / methods. Spinal Cord Neoplasms / radiography. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 16575331.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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91. Al-Habib A, Lach B, Al Khani A: Intracerebral rhabdoid and papillary meningioma with leptomeningeal spread and rapid clinical progression. Clin Neuropathol; 2005 Jan-Feb;24(1):1-7
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  • OBJECTIVE AND IMPORTANCE: Rhabdoid meningioma (RM) is a relatively new, Grade III tumor entity according to the latest WHO classification.
  • We report rhabdoid and partly papillary, highly anaplastic, intracerebral meningioma with diffuse leptomeningeal spread and distant SCF metastasis to the cervical cord.
  • CLINICAL PRESENTATION: This 27-year-old female was admitted to the hospital with radiological findings suggestive of a primary brain tumor or a metastasis.
  • After subtotal resection and during radiotherapy, follow-up MRI revealed recurrence, metastasis to meninges at the high cervical level, and diffuse basal leptomeningeal enhancement indicating infiltrating tumor.
  • The recurrent tumor diffusely infiltrated leptomeninges and subarachnoid space.
  • The combination of the histological anaplasia with the highest reported proliferation rate, and loss of the cohesion of neoplastic cells led to diffused infiltration of the leptomeninges and metastasis to the spinal cord.
  • [MeSH-minor] Adult. Brain / pathology. Disease Progression. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Time Factors

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  • (PMID = 15696777.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 34
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92. Nishimura M, Suzuki S, Satoh T, Naito S: Tissue-specific mRNA expression profiles of human solute carrier 35 transporters. Drug Metab Pharmacokinet; 2009;24(1):91-9
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  • The mRNA expression level of each target transporter was analyzed in total RNA from single and pooled specimens of adult human tissues (adipose tissue, adrenal gland, bladder, bone marrow, brain, cerebellum, colon, heart, kidney, liver, lung, mammary gland, ovary, pancreas, peripheral leukocytes, placenta, prostate, retina, salivary gland, skeletal muscle, small intestine, smooth muscle, spinal cord, spleen, stomach, testis, thymus, thyroid gland, tonsil, trachea, and uterus), from pooled specimens of fetal human tissues (brain, heart, kidney, liver, spleen, and thymus), and from three human cell lines (HeLa cell line ATCC#: CCL-2, human cell line Hep G2, and human breast carcinoma cell line MDA-435) by real-time reverse transcription PCR using an Applied Biosystems 7500 Fast Real-Time PCR System.
  • The mRNA expression of SLC35As, SLC35Bs, SLC35Cs, SLC35D1, SLC35D2, SLC35Es, and SLC35F5 was found to be ubiquitous in both adult and fetal tissues.
  • SLC35D3 mRNA was expressed at the highest levels in the adult retina.
  • SLC35F1 mRNA was expressed at high levels in the adult and fetal brain.
  • SLC35F2 mRNA was expressed at the highest levels in the adult salivary gland.
  • Both SLC35F3 and SLC35F4 mRNAs were expressed at the highest levels in the adult cerebellum.
  • Our newly determined expression profiles were used to study the gene expression in 31 adult human tissues, 6 fetal human tissues, and 3 cell lines, and tissues with high transcriptional activity for human SLC35 transporters were identified.
  • [MeSH-minor] Adult. Cell Line, Tumor. Humans. Organ Specificity. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19252338.001).
  • [ISSN] 1880-0920
  • [Journal-full-title] Drug metabolism and pharmacokinetics
  • [ISO-abbreviation] Drug Metab. Pharmacokinet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Monosaccharide Transport Proteins; 0 / Nucleotide Transport Proteins; 0 / RNA, Messenger
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93. Brahmanday GR, Gheorghe G, Jaiyesimi IA, Orazi A, Zekman R, Parikh R, Wills SM, Einhorn LH: Primary mediastinal germ cell tumor evolving into an extramedullary acute megakaryoblastic leukemia causing cord compression. J Clin Oncol; 2008 Oct 1;26(28):4686-8
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  • [Title] Primary mediastinal germ cell tumor evolving into an extramedullary acute megakaryoblastic leukemia causing cord compression.
  • [MeSH-major] Leukemia, Megakaryoblastic, Acute / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Spinal Cord Compression / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Tomography, Emission-Computed. Tomography, X-Ray Computed

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  • (PMID = 18824716.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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94. Iplikcioglu AC, Hatiboglu MA, Ozek E, Dinc C, Erdal M: Surgical removal of spinal mass lesions with open door laminoplasty. Cent Eur Neurosurg; 2010 Nov;71(4):213-8
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  • [Title] Surgical removal of spinal mass lesions with open door laminoplasty.
  • We adapted this technique for the removal of spinal tumors all along the spinal axis.
  • Location of the tumor was intradural-intramedullary in 7, intradural-extramedullary in 6 and extradural in 4 patients.
  • Neither spinal malalignment on the coronal plane nor displacement of bone flap (laminoplasty flap) were observed on postoperative CT and MR examinations.
  • CONCLUSION: Open door laminoplasty is a simple procedure and has two main advantages over the classical laminectomy procedure; a lower incidence of spinal deformities with or without neurological deficits and an absence of epidural scar tissue.
  • This procedure can be used in all spinal cases with intraspinal mass lesions.
  • [MeSH-major] Laminectomy / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Kyphosis / etiology. Kyphosis / prevention & control. Magnetic Resonance Imaging. Male. Middle Aged. Muscle Weakness / etiology. Neurologic Examination. Postoperative Complications / epidemiology. Postoperative Complications / therapy. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20458672.001).
  • [ISSN] 1868-4912
  • [Journal-full-title] Central European neurosurgery
  • [ISO-abbreviation] Cent Eur Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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95. Mohindra S, Gupta SK: Cervicobulbar intramedullary lipoma. Spine J; 2009 Mar;9(3):e12-6
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  • BACKGROUND CONTEXT: Spinal lipomas not associated with spinal dysraphism are rare entities.
  • STUDY DESIGN/SETTING: An extremely rare case of medullary lipoma extending into posterior fossa is described in an adult, not associated with spinal dysraphism.
  • METHODS: A young male presented with high cord myelopathy in the form of spastic quadriparesis.
  • RESULTS: Surgical excision of tumor provided satisfactory resolution of symptoms.
  • CONCLUSIONS: Medullary lipomas may present with features of high cord compression and myelopathy.
  • Even when total tumor excision is not feasible, subtotal removal and decompression provides long lasting symptom-free survival.
  • [MeSH-major] Lipoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures

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  • (PMID = 18619912.001).
  • [ISSN] 1878-1632
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Scottish Bone Tumor Registry, Sharma H, Mehdi SA, MacDuff E, Reece AT, Jane MJ, Reid R: Paget sarcoma of the spine: Scottish Bone Tumor Registry experience. Spine (Phila Pa 1976); 2006 May 20;31(12):1344-50
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  • [Title] Paget sarcoma of the spine: Scottish Bone Tumor Registry experience.
  • STUDY DESIGN: Retrospective case study of 13 cases of Paget sarcoma of the spine accrued from a prospectively collected Tumor Registry database.
  • METHODS: Between January 1944 and December 2003, 89 patients were registered with a diagnosis of Paget sarcoma in the Scottish Bone Tumor Registry.
  • [MeSH-major] Lumbar Vertebrae. Osteitis Deformans. Sacrum. Sarcoma. Spinal Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Nerve Compression Syndromes / complications. Nerve Compression Syndromes / etiology. Nervous System Diseases / etiology. Registries. Retrospective Studies. Spinal Cord Compression / complications. Spinal Cord Compression / etiology. Spinal Nerve Roots. Survival Analysis. Tomography, X-Ray Computed


97. Choi YL, Kim CJ, Matsuo T, Gaetano C, Falconi R, Suh YL, Kim SH, Shin YK, Park SH, Chi JG, Thiele CJ: HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. J Neurooncol; 2005 May;73(1):19-27
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  • HUlip is highly expressed only in the fetal brain and spinal cord, and is undetected in the adult brain.
  • Ten human brains at different developmental stages and 118 cases of nervous system tumor tissues were examined by immunohistochemistry.
  • Twelve related tumor cell lines were also analyzed by northern blotting and immunoblotting.
  • Among tumors, hUlip expression was easily detected in tumor cells undergoing neuronal differentiation such as ganglioneuroblastomas and ganglioneuromas.
  • Furthermore, hUlip immunoreactivity was also found in various brain tumors showing neuronal differentiation: central neurocytomas (6 of 6 cases were positive), medulloblastomas (5/11), atypical teratoid rhabdoid tumor (1/1) and gangliogliomas (4/7).
  • [MeSH-minor] Astrocytes / cytology. Astrocytes / metabolism. Cell Differentiation / genetics. Cell Differentiation / physiology. Cell Line, Tumor. Female. Gestational Age. Humans. Immunohistochemistry. Male. Neuroblastoma / genetics. Neuroblastoma / metabolism. Neurons / cytology. Neurons / metabolism

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  • (PMID = 15933812.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DPYSL3 protein, human; 0 / Muscle Proteins
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98. Benzagmout M, Boujraf S, Oulali N, Chbani L, Amarti A, Chakour K, Chaoui Mel F: Intradural extramedullary ependymoma: is there constantly a hormonal relationship? Surg Neurol; 2008 Nov;70(5):536-8; discussion 538
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ependymoma is a glial tumor that occurs in the central nervous system.
  • The intradural extramedullary location of this neoplasm is very rare.
  • The authors report a case of spinal intradural extramedullary ependymoma in a male and discuss its pathogenesis as well as its clinical, radiological, and therapeutical features.
  • Magnetic resonance imaging revealed an enhanced cervical intradural extramedullary tumor extending from the bulbomedullary junction to the C3 level, with severe spinal cord compression.
  • One year and half later, a local recurrence associated to a small cerebellar lesion was noticed justifying a second spinal intervention.
  • Both surgical interventions demonstrated an intradural extramedullary ependymoma without attachment to the spinal cord or to the dura mater.
  • CONCLUSION: The insufficiency of hormonal theory to explain solely the pathogenesis of this tumor might reveal other potential factors that have not been discussed in earlier literature.
  • [MeSH-major] Ependymoma / diagnosis. Ependymoma / etiology. Gonadal Steroid Hormones / physiology. Neoplasm Recurrence, Local / etiology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Adult. Cervical Vertebrae. Humans. Male. Sex Factors

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  • (PMID = 18207493.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones
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99. Bernal-García LM, Cabezudo-Artero JM, Ortega-Martínez M, Porras-Estrada LF, Fernández-Portales I, Ugarriza-Echebarrieta LF, Molina-Orozco M, Pimentel-Leo JJ: [Intramedullary schwannomas. Report of two cases]. Neurocirugia (Astur); 2010 Jun;21(3):232-8; discussion 238-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Neurinomas intramedulares. Presentación de dos casos de un tumor infrecuente.
  • They are very rare and account for 0.3 to 1.5 % of all spinal schwannomas.
  • We are presenting two patients in whom an intramedullary tumor was removed.
  • [MeSH-major] Neurilemmoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 20571727.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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100. Chen CT, Foo NH, Liu WS, Chen SH: Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms. Pediatr Neonatol; 2008 Jun;49(3):77-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms.
  • BACKGROUND: Human umbilical cord blood cells (HUCBCs) were used to investigate the mechanisms underlying the beneficial effects of cord blood cells in spinal cord injury (SCI).
  • (2) Laminectomy+SCI+human adult peripheral blood mononucleocytes (PBMCs) (5 x 10(6)/0.3 mL); and (3) Laminectomy+SCi+HUCBCs (5 x 10(6)/0.3 mL).
  • SCI was induced by compressing the spinal cord for 1 minute with an aneurysm clip calibrated to 55 g closing pressure.
  • Serum levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-10, were assayed.
  • Furthermore, to determine if glial cell line-derived neurotrophic factor (GDNF) or vascular endothelial growth factor (VEGF) could be detected in the spinal cord injured area after systemic HUCBC infusion, analysis of these two molecules was conducted by immunofluorescence.
  • Both VEGF and GDNF could be detected in the injured spinal cord after transplantation of HUCBC, but not PBMC, cells.
  • [MeSH-major] Cord Blood Stem Cell Transplantation. Inflammation / prevention & control. Spinal Cord Injuries / therapy
  • [MeSH-minor] Animals. Glial Cell Line-Derived Neurotrophic Factor / analysis. Hindlimb / physiopathology. Humans. Immunohistochemistry. Interleukin-10 / blood. Motor Activity. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / blood. Vascular Endothelial Growth Factor A / blood

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  • (PMID = 18947003.001).
  • [ISSN] 1875-9572
  • [Journal-full-title] Pediatrics and neonatology
  • [ISO-abbreviation] Pediatr Neonatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Tumor Necrosis Factor-alpha; 0 / Vascular Endothelial Growth Factor A; 130068-27-8 / Interleukin-10
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