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1. Petit A, Sellers DL, Liebl DJ, Tessier-Lavigne M, Kennedy TE, Horner PJ: Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Proc Natl Acad Sci U S A; 2007 Nov 6;104(45):17837-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.
  • Adult neural progenitor cells (aNPCs) exhibit limited migration in vivo with the exception of the rostral migratory stream and injury-induced movement.
  • These studies demonstrate that aNPCs respond principally to a repulsive cue expressed at the embryonic floor plate (FP) and also the injured adult CNS.
  • Adult spinal cord progenitor cells (aSCPs) were seeded onto organotypic slice preparations of the intact embryonic or injured adult spinal cord.
  • When slices were prepared from injured spinal cord, aSCP migration away from the injury core was Ntn-1-dependent.

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  • (PMID = 17978191.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / PHS HHS / / R01 N546724
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nerve Growth Factors; 0 / Tumor Suppressor Proteins; 147336-22-9 / Green Fluorescent Proteins; 158651-98-0 / netrin-1
  • [Other-IDs] NLM/ PMC2077035
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2. Wu TC, Guo WY, Lirng JF, Wong TT, Chang FC, Luo CB, Teng MM, Chang CY: Spinal cord hemangioblastoma with extensive syringomyelia. J Chin Med Assoc; 2005 Jan;68(1):40-4
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  • [Title] Spinal cord hemangioblastoma with extensive syringomyelia.
  • An incidental magnetic resonance imaging (MRI) finding of one small intramedullary enhancing nodule at spinal cord level T10-11 with long-segment syrinx formation suggested the diagnosis of spinal hemangioblastoma with syringomyelia.
  • Surgical removal of the tumor and decompression of the spinal cord with opening of the syrinx were performed smoothly, and the pathology confirmed the diagnosis of spinal hemangioblastoma.
  • Reviewing the literature, MRI is the examination of choice for spinal hemangioblastomas, and is helpful in preoperative planning and the differential diagnosis of spinal cord neoplasms and vascular lesions.
  • [MeSH-major] Hemangioblastoma / pathology. Spinal Cord Neoplasms / pathology. Syringomyelia / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Spinal Cord / pathology. Spinal Cord / surgery. Treatment Outcome

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  • (PMID = 15742863.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 16
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3. Qin MJ, Peng B, Luo DD, Chen YD: [Microsurgical treatment of intramedullary tumor in the superior cervical spinal cord]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Feb;30(2):368-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microsurgical treatment of intramedullary tumor in the superior cervical spinal cord].
  • OBJECTIVE: To evaluate the curative effect of microsurgery for intramedullary tumor in the superior cervical spinal cord.
  • METHODS: The clinical manifestations, microsurgical methods and results were reviewed retrospectively in 12 patients with intramedullary tumors in the superior cervical spinal cord.
  • The spinal functions of patients, graded by McCormick scale system 3 months after the operations, were improved in 8 cases and remained unchanged in 4 cases.
  • Nine patients were followed up for 1-3 years after the operations, and no tumor recurrence was found in 8 cases with total tumor resection.
  • CONCLUSION: Radical microneurosurgery is currently the best choice for the treatment of intradullary tumor in the superior cervical spinal cord.
  • [MeSH-major] Microsurgery / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Cervical Vertebrae. Ependymoma / diagnosis. Ependymoma / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20159725.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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4. Chamberlain MC: Temozolomide for recurrent low-grade spinal cord gliomas in adults. Cancer; 2008 Sep 1;113(5):1019-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temozolomide for recurrent low-grade spinal cord gliomas in adults.
  • BACKGROUND: There is no standard therapy for surgery- and radiotherapy-resistant, recurrent, low-grade spinal cord gliomas.
  • Therefore, a retrospective study of temozolomide (TMZ) in adults with recurrent low-grade spinal cord gliomas with a primary objective of determining progression-free survival (PFS) was performed.
  • METHODS: Twenty-two patients (11 men and 11 women) aged 20 years to 55 years (median, 35 years) with recurrent spinal cord gliomas (World Health Organization grade 2 astrocytoma in 19 patients and oligoastrocytoma in 3 patients) were treated.
  • Time to tumor progression ranged from 2 months to 28 months (median, 14.5 months).
  • CONCLUSIONS: TMZ demonstrated modest efficacy with acceptable toxicity in this cohort of adult patients with recurrent low-grade spinal cord gliomas.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Dacarbazine / analogs & derivatives. Glioma / drug therapy. Spinal Cord Neoplasms / drug therapy
  • [MeSH-minor] Adult. Disease-Free Survival. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Retrospective Studies

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18615600.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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5. Anan M, Inoue R, Ishii K, Abe T, Fujiki M, Kobayashi H, Goya T, Nakazato Y: A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord. Hum Pathol; 2009 Jun;40(6):898-901

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord.
  • This report presents the first case of a rosette-forming glioneuronal tumors arising from the spinal cord.
  • Magnetic resonance imaging demonstrated a mass in the cervicothoracic spinal cord that suggested an intramedullary spinal tumor.
  • A total gross resection of the tumor was performed.
  • As is typical of rosette-forming glioneuronal tumors of the fourth ventricle, this spinal cord example manifested neurocytic and astrocytic components.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Astrocytoma / pathology. Female. Humans. Rosette Formation

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  • [CommentIn] Hum Pathol. 2009 Oct;40(10):1510; author reply 1510 [19616823.001]
  • (PMID = 19269010.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Grimm S, Chamberlain MC: Adult primary spinal cord tumors. Expert Rev Neurother; 2009 Oct;9(10):1487-95

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult primary spinal cord tumors.
  • Primary spinal cord tumors represent 2-4% of all neoplasms of the CNS.
  • Primary spinal cord tumors are anatomically separable into two broad categories: intradural intramedullary and intradural extramedullary.
  • Resective surgery can usually be accomplished with spinal ependymomas owing to separation of tumor from spinal cord and, when complete, require no further therapy.
  • By contrast, spinal cord gliomas infiltrate the myelon and, consequently, surgery is nearly always incomplete.
  • Chemotherapy is administered for recurrent primary spinal cord tumors without other options, that is, reoperation or re-irradiation.
  • Problematic, however, is the lack of clinical trials in general for these CNS tumors and for spinal cord tumors in particular.
  • Early recognition of the signs and symptoms of primary spinal cord tumors allows for early treatment, potentially minimizes neurologic morbidity and improves outcome.
  • Primary treatment is surgery in essentially all spinal cord tumors, and predictors of outcome include preoperative functional status, histological grade of tumor and extent of surgical resection.
  • [MeSH-major] Spinal Cord Neoplasms / classification. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Neurosurgical Procedures. Young Adult

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  • (PMID = 19831838.001).
  • [ISSN] 1744-8360
  • [Journal-full-title] Expert review of neurotherapeutics
  • [ISO-abbreviation] Expert Rev Neurother
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 82
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7. Mendiratta-Lala M, Kader Ellika S, Gutierrez JA, Patel SC, Jain R: Spinal cord pilomyxoid astrocytoma: an unusual tumor. J Neuroimaging; 2007 Oct;17(4):371-4
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  • [Title] Spinal cord pilomyxoid astrocytoma: an unusual tumor.
  • We present the imaging findings of a case of spinal pilomyxoid astrocytoma in a 29-year-old woman with history of neck and back pain and weakness of bilateral upper extremities.
  • Spinal pilomyxoid astrocytoma is rare with only three reported cases in pediatric population in the literature.
  • This report illustrates the MR findings of an unusual case of intradural extramedullary spinal pilomyxoid tumor in an adult patient.
  • [MeSH-major] Astrocytoma / diagnosis. Magnetic Resonance Imaging. Myxoma / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Contrast Media. Female. Humans

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  • (PMID = 17894633.001).
  • [ISSN] 1051-2284
  • [Journal-full-title] Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • [ISO-abbreviation] J Neuroimaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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8. Kinoshita Y, Akatsuka K, Ohtake M, Kamitani H, Watanabe T: Primary intramedullary spinal cord germinoma. Neurol Med Chir (Tokyo); 2010;50(7):592-4
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  • [Title] Primary intramedullary spinal cord germinoma.
  • A 21-year-old woman presented with an intramedullary spinal cord germinoma and a history of gait disturbance and elimination disorder.
  • After partial reduction of the intramedullary mass, histological findings revealed that the tumor was typical germinoma.
  • No recurrence of the tumor has been detected 3 years after the operation, and no dissemination into the cranial area was detected.
  • Cisplatin and etoposide chemotherapy combined with radiotherapy is recommended for primary spinal germinoma, and is effective for inhibition of both tumor dissemination and recurrence.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Lumbar Vertebrae. Radiotherapy, Adjuvant. Spinal Cord / pathology. Spinal Cord / surgery. Thoracic Vertebrae. Young Adult

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  • (PMID = 20671389.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Youn DH, Wang H, Jeong SJ: Exogenous tumor necrosis factor-alpha rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn. J Neurosci Res; 2008 Oct;86(13):2867-75
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  • [Title] Exogenous tumor necrosis factor-alpha rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn.
  • The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) is involved in the generation of inflammatory and neuropathic pain.
  • This study investigated if TNF-alpha has any effect on spinal synaptic and/or sensory transmission by using whole-cell recordings of substantia gelatinosa (SG) neurons in transverse lumbar spinal cord slices of adult rats and by using behavioral tests.
  • After intrathecal administration of TNF-alpha in adult rats, spontaneous hind paw withdrawal behavior and thermal hyperalgesia were rapidly induced (approximately 30 min), while mechanical allodynia slowly developed.
  • Because this study also found high protein expression of TNFR1 in the adult dorsal root ganglion and no change of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) induced whole-cell currents by TNF-alpha, we conclude that presynaptic TNFR1 at Adelta/C primary afferent terminals contributes to the rapid alteration of synaptic transmission in the spinal SG, and the development of abnormal pain hypersensitivity by exogenous TNF-alpha.
  • [MeSH-major] Pain / physiopathology. Posterior Horn Cells / drug effects. Synaptic Transmission / drug effects. Synaptic Transmission / physiology. Tumor Necrosis Factor-alpha / pharmacology
  • [MeSH-minor] Animals. Blotting, Western. Excitatory Postsynaptic Potentials / drug effects. Excitatory Postsynaptic Potentials / physiology. Hyperalgesia / chemically induced. Hyperalgesia / physiopathology. Male. Neurons, Afferent / drug effects. Neurons, Afferent / metabolism. Organ Culture Techniques. Patch-Clamp Techniques. Rats. Rats, Sprague-Dawley. Receptors, Tumor Necrosis Factor, Type I / metabolism

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18543334.001).
  • [ISSN] 1097-4547
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Tumor Necrosis Factor, Type I; 0 / Tumor Necrosis Factor-alpha
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10. Matsuyama Y, Sakai Y, Katayama Y, Imagama S, Ito Z, Wakao N, Sato K, Kamiya M, Yukawa Y, Kanemura T, Yanase M, Ishiguro N: Surgical results of intramedullary spinal cord tumor with spinal cord monitoring to guide extent of resection. J Neurosurg Spine; 2009 May;10(5):404-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical results of intramedullary spinal cord tumor with spinal cord monitoring to guide extent of resection.
  • OBJECT: The authors investigated the outcome of intramedullary spinal cord tumor surgery, focusing on the effect of preoperative neurological status on postoperative mobility and the extent of tumor excision guided by intraoperative spinal cord monitoring prospectively.
  • METHODS: Intramedullary spinal cord tumor surgery was performed in 131 patients between 1997 and 2007.
  • The tumor types included astrocytoma (12 cases), ependymoma (46 cases), hemangioblastoma (16 cases), cavernous hemangioma (17 cases), and others (15 cases overall: gangliocytoma, 1; germ cell tumor, 1; lymphoma, 3; neurinoma, 1; meningioma, 1; oligodendroglioma, 1; sarcoidosis, 2; glioma, 1; and unknown, 4).
  • However, the rate of postoperative deterioration was 31.5%, which is relatively high, and patients should be fully informed of this concern prior to intramedullary spinal cord tumor surgery.
  • [MeSH-major] Monitoring, Intraoperative / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / surgery. Child. Ependymoma / surgery. Female. Follow-Up Studies. Hemangioblastoma / surgery. Hemangioma, Cavernous / surgery. Humans. Male. Middle Aged. Postoperative Complications. Prognosis. Prospective Studies. Walking

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  • (PMID = 19442001.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Hsu W, Bettegowda C, Jallo GI: Intramedullary spinal cord tumor surgery: can we do it without intraoperative neurophysiological monitoring? Childs Nerv Syst; 2010 Feb;26(2):241-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord tumor surgery: can we do it without intraoperative neurophysiological monitoring?
  • OBJECTIVE: The objective of this review is to discuss the utilization of intraoperative neurophysiological monitoring (IONM) during spinal cord tumor surgery.
  • DISCUSSION: The literature generally supports the use of intraoperative monitoring during surgery for spinal cord lesions.
  • [MeSH-major] Monitoring, Intraoperative / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Practice Guidelines as Topic. Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord / surgery

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  • (PMID = 19902217.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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12. Kolstad F, Rygh OM, Selbekk T, Unsgaard G, Nygaard OP: Three-dimensional ultrasonography navigation in spinal cord tumor surgery. Technical note. J Neurosurg Spine; 2006 Sep;5(3):264-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three-dimensional ultrasonography navigation in spinal cord tumor surgery. Technical note.
  • The authors describe the technical application of three-dimensional (3D) ultrasonography navigation in spinal cord tumor surgery.
  • The spinal cord is a complex neurological structure in which there is the potential for causing neurological morbidity during tumor resection.
  • Standard neuronavigation systems based on computed tomography or C-arm images are not adapted to tumor surgery in the spinal cord.
  • During surgery, two-dimensional ultrasound images were acquired and reconstructed into 3D image data to assist in tumor resection.
  • Spinal cord tumors were visualized using ultrasonography, and 3D ultrasonography-guided tumor biopsy sampling and resection were performed.
  • The practice of attaching the reference frame to a spinous process adjacent to the spinal cord tumor, as well as performing image acquisition just before starting the resection, reduced the possible sources of inaccuracy.
  • The technical application of a navigation system based on intraoperative 3D ultrasound image reconstruction seems feasible and may have the potential of improving functional outcome in association with spinal cord tumor surgery.
  • [MeSH-major] Glioma / surgery. Hemangioma, Cavernous, Central Nervous System / surgery. Imaging, Three-Dimensional. Neuronavigation / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged, 80 and over. Cervical Vertebrae. Female. Humans. Male. Middle Aged. Thoracic Vertebrae

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  • (PMID = 16961090.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. White JB, Miller GM, Layton KF, Krauss WE: Nonenhancing tumors of the spinal cord. J Neurosurg Spine; 2007 Oct;7(4):403-7
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  • [Title] Nonenhancing tumors of the spinal cord.
  • In the brain, the presence or absence of gadolinium enhancement is often an indicator of tumor invasiveness and/or grade.
  • In the spinal cord, however, contrast enhancement has been shown in all tumor types, regardless of grade.
  • In this study the authors explore the incidence of nonenhancing tumors of the spinal cord and the clinical course of patients with these lesions.
  • METHODS: A retrospective analysis was conducted in which investigators examined the patterns of enhancement of histologically proven intramedullary spinal cord tumors that had been evaluated at the Mayo Clinic between 1998 and 2002.
  • Histologically, a majority of tumors were astrocytomas (eight low-grade and two high-grade lesions); one tumor was a subependymoma.
  • Tumors spanned from two to seven levels and were located throughout the spinal cord (four cervical, three cervicothoracic, one thoracic, and three thoracolumbar).
  • CONCLUSIONS: A number of intramedullary spinal cord tumors will not enhance after addition of contrast agents.
  • The absence of enhancement does not imply the absence of tumor.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / radiography. Glioma, Subependymal / pathology. Glioma, Subependymal / radiography. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiography
  • [MeSH-minor] Adult. Aged. Child. Child, Preschool. Contrast Media. Female. Gadolinium DTPA. Humans. Image Enhancement. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17933314.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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14. Guzel A, Tatli M, Belen D, Seckin H: Spinal cord compression of primary extragonadal giant yolk sac tumor. Spinal Cord; 2007 Mar;45(3):254-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord compression of primary extragonadal giant yolk sac tumor.
  • OBJECTIVE: To report an adult male patient with a primary extragonadal giant yolk sac tumor presenting with acute spinal cord compression.
  • Posteriorly, the third lumbar vertebral body was destructed and the tumor was compressing the dural sac.
  • Pathological diagnosis was a yolk sac tumor.
  • CONCLUSION: Yolk sac tumor should be considered in young adult male patients presenting with acute paraparesis even without any signs or medical history of a testis tumor.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery. Spinal Cord Compression / surgery
  • [MeSH-minor] Adult. Decompression, Surgical. Humans. Lumbosacral Region / pathology. Lumbosacral Region / surgery. Magnetic Resonance Imaging. Male. Paraparesis / etiology. Tomography, X-Ray Computed

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  • (PMID = 16733519.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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15. Jang WY, Lee JK, Lee JH, Kim JH, Kim SH, Lee KH, Lee MC: Intramedullary subependymoma of the thoracic spinal cord. J Clin Neurosci; 2009 Jun;16(6):851-3
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  • [Title] Intramedullary subependymoma of the thoracic spinal cord.
  • The patient developed a monoparesis of the right leg after a subtotal resection of the tumor.
  • During the 30 months of follow-up the neurological deficit improved and the patient remained symptom free without progression of the remnant tumor.
  • A complete resection of the tumor is usually curative with improved function.
  • In patients with poor delineation between the tumor and the spinal cord, subtotal removal and close follow-up should be considered.
  • [MeSH-major] Glioma, Subependymal / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Laminectomy. Low Back Pain / etiology. Magnetic Resonance Imaging. Neural Pathways / injuries. Neural Pathways / surgery. Neurosurgical Procedures / methods. Paresis / etiology. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Radiotherapy. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 19297162.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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16. Patil CG, Patil TS, Lad SP, Boakye M: Complications and outcomes after spinal cord tumor resection in the United States from 1993 to 2002. Spinal Cord; 2008 May;46(5):375-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complications and outcomes after spinal cord tumor resection in the United States from 1993 to 2002.
  • OBJECTIVE: Data on patient outcomes after surgery for spinal cord tumors have been derived from single-institution series.
  • METHODS: The National Inpatient Sample (NIS) was used to identify 19,017 admissions for resection of a spinal cord tumor in the United States from 1993 to 2002.
  • CONCLUSION: A national perspective on inpatient outcomes after resection of spinal cord tumors has been provided.
  • [MeSH-major] Neurosurgical Procedures / mortality. Outcome Assessment (Health Care). Postoperative Complications / mortality. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Child. Child, Preschool. Cohort Studies. Comorbidity. Continental Population Groups / statistics & numerical data. Databases, Factual. Female. Hospital Mortality. Humans. Infant. Infant, Newborn. Inpatients / statistics & numerical data. Length of Stay / statistics & numerical data. Lung Diseases / epidemiology. Male. Middle Aged. Postoperative Hemorrhage / epidemiology. Retrospective Studies. United States / epidemiology. Urologic Diseases / epidemiology

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  • (PMID = 18071353.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Kato M, Nakamura H, Terai H, Konishi S, Nagayama R, Takaoka K: Why does delay exist in the diagnosis of intradural spinal cord tumor despite the availability of MRI? J Clin Neurosci; 2008 Aug;15(8):880-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Why does delay exist in the diagnosis of intradural spinal cord tumor despite the availability of MRI?
  • To elucidate the reasons for delay in the diagnosis of spinal cord tumors despite the availability of MRI in Japan, we reviewed the clinical records of 60 patients with tumors with reference to histological diagnosis, initial symptoms, time interval between onset of the initial symptoms and the first visit to a physician, and the subsequent interval to diagnosis using MRI.
  • The possibility of thoracic spinal tumor should be kept in mind when unexplained low back pain persists in response to various treatments.
  • [MeSH-major] Spinal Cord Neoplasms / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Time Factors. Tomography, X-Ray Computed / methods

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  • (PMID = 18539463.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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18. Quiñones-Hinojosa A, Lyon R, Zada G, Lamborn KR, Gupta N, Parsa AT, McDermott MW, Weinstein PR: Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor function. Neurosurgery; 2005 May;56(5):982-93; discussion 982-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor function.
  • OBJECTIVE: Intraoperative monitoring of transcranial motor evoked potentials (TcMEPs) has been investigated recently as a means of preventing motor deficits associated with resection of intramedullary spinal cord tumors (IMSCTs).
  • In this study, we hypothesized that changes in the intraoperative MEPs during tumor resection correlate with postoperative motor function deficits.
  • Attention to such quantitative intraoperative monitoring data may help to minimize postoperative motor deficits by avoiding or correcting excessive spinal cord manipulation and modifying surgical technique during tumor resection.
  • [MeSH-major] Brain / physiopathology. Brain Stem Neoplasms / surgery. Evoked Potentials, Motor / physiology. Motor Activity / physiology. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Electric Stimulation. Female. Follow-Up Studies. Humans. Length of Stay. Male. Monitoring, Intraoperative. Retrospective Studies

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  • (PMID = 15854246.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Donovan DJ, Freeman JH: Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report. Spine (Phila Pa 1976); 2006 Jun 15;31(14):E460-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report.
  • STUDY DESIGN: We present the case of a patient with a solitary neoplasm of the intramedullary spinal cord.
  • OBJECTIVE: The tumor caused findings of Brown-Séquard syndrome and was the initial presentation of widely metastatic renal cell carcinoma (RCC).
  • SUMMARY OF BACKGROUND DATA: Metastasis of the intramedullary spinal cord has been uncommonly reported and is extremely rare as the initial sign of a disseminated carcinoma.
  • METHODS: The tumor was resected, and the patient's neurologic deficits slowly improved.
  • The histopathology suggested an epithelioid neoplasm.
  • However, despite expert review, the diagnosis was nonspecific, and the tumor appeared benign.
  • RESULTS: It soon recurred in the spinal cord, and repeat imaging studies showed numerous new metastases and a primary renal neoplasm.
  • CONCLUSIONS: Despite being uncommon, spinal cord metastases should be considered in some patients before surgery because it may expedite diagnosis, mitigate the need for surgery, and improve the quality of life for these patients.
  • Clinical factors suggesting metastasis include a personal or family history of malignancy or conditions predisposing to it, the presence of multiple tumors in the spinal cord or elsewhere, nonspecific constitutional symptoms, such as weight loss or decreased appetite, and, specifically for RCC, an abnormally increased hematocrit.
  • [MeSH-major] Brown-Sequard Syndrome / etiology. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16778676.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Muñoz E, Prat A, Adamo B, Peralta S, Ramón y Cajal S, Valverde C: A rare case of malignant solitary fibrous tumor of the spinal cord. Spine (Phila Pa 1976); 2008 May 20;33(12):E397-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of malignant solitary fibrous tumor of the spinal cord.
  • OBJECTIVE: We present a case of an ambulatory patient with a solitary fibrous tumor of the spinal cord.
  • SUMMARY OF BACKGROUND DATA: Solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor of the pleural cavity, increasingly recognized at numerous extrathoracic sites, including, among others, prostate, kidney, and thyroid.
  • The spinal cord is an extremely rare localization of SFTs with only 17 cases reported in the literature since 1996.
  • RESULTS: We report the first case of spinal cord SFT with visceral dissemination years after the primary diagnosis, despite benign histologic features of the primary tumor.
  • [MeSH-major] Liver Neoplasms / secondary. Lung Neoplasms / secondary. Solitary Fibrous Tumors / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Antineoplastic Combined Chemotherapy Protocols. Humans. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Male. Orthopedic Procedures. Pneumonectomy. Proto-Oncogene Proteins c-bcl-2 / analysis. Radiotherapy. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Vimentin / analysis

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  • (PMID = 18496336.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Vimentin
  • [Number-of-references] 14
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21. Ahlhelm FJ, Fries P, Nabhan A, Reith W: [Spinal tumors]. Radiologe; 2010 Feb;50(2):165-78; quiz 179-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal tumors].
  • Spinal tumors can be intramedullary, intradural (within the meninges), or extradural (between the meninges and the bones), or they may extend secondary to the spine from other locations.
  • Vertebral hemangioma represents the most common benign tumor of the spine.
  • Metastases, lymphoma, and multiple myeloma are the most frequent malignant spinal tumors.
  • [MeSH-major] Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Spinal Cord Neoplasms / diagnosis. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Angiography, Digital Subtraction. Diagnosis, Differential. Female. Humans. Image Enhancement. Male. Middle Aged. Spinal Cord / pathology. Spine / pathology

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  • (PMID = 19669725.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
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22. Mobley B, Kalani MY, Harsh GR 4th, Edwards MS, Vogel H: Papillary tumor of the spinal cord: report of 2 cases. Am J Surg Pathol; 2009 Aug;33(8):1191-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary tumor of the spinal cord: report of 2 cases.
  • Intramedullary spinal cord tumors constitute a small fraction of central nervous system tumors in the pediatric population; of these, the majority are ependymomas or astrocytomas.
  • We report 2 pediatric spinal cord tumor cases with unique morphologic and immunohistochemical features.
  • The first patient presented at age 7 with an intramedullary tumor of the thoracic spine.
  • The second patient presented at age 17 with an intramedullary tumor of the cervical spine.
  • The tumor recurred locally and in the cerebellum.
  • The clinical features, including propensity for recurrence and remote subarachnoid spread, and the pathologic features of these tumors are reminiscent of papillary tumor of the pineal region, ependymoma, and choroid plexus papilloma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Male. Neurosurgical Procedures. Radiotherapy

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  • (PMID = 19417584.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Shin DA, Kim SH, Yoon DH, Kim TS: A dumbbell-shaped solitary fibrous tumor of the cervical spinal cord. Yonsei Med J; 2008 Feb 29;49(1):167-70
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  • [Title] A dumbbell-shaped solitary fibrous tumor of the cervical spinal cord.
  • MRI revealed an extramedullary, extradural, dumbbell-shaped spinal cord tumor with C6 to C7 iso- and hyperintensity on T1 and T2 weighted imaging, respectively.
  • Immunohistochemistry was positive for CD34, CD99, and negative for EMA, SMA, and S100; solitary fibrous tumor (SFT) was confirmed.
  • [MeSH-major] Cervical Vertebrae / pathology. Solitary Fibrous Tumors / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 18306486.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2615256
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24. Li D, Brennan JW, Buckland M, Parkinson JF: Bronchogenic carcinoid metastasis to the intramedullary spinal cord. J Clin Neurosci; 2010 Sep;17(9):1196-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bronchogenic carcinoid metastasis to the intramedullary spinal cord.
  • Spinal-cord compression from carcinoid metastasis is uncommon, and intradural spinal carcinoid is rare.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Carcinoma, Bronchogenic / diagnosis. Lung Neoplasms / diagnosis. Spinal Cord Compression / diagnosis. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Female. Humans

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  • [Copyright] Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20627579.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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25. Schellinger KA, Propp JM, Villano JL, McCarthy BJ: Descriptive epidemiology of primary spinal cord tumors. J Neurooncol; 2008 Apr;87(2):173-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Descriptive epidemiology of primary spinal cord tumors.
  • OBJECT: There is little population-based data available on primary spinal cord tumors.
  • The objective of this study was to estimate the incidence of both non-malignant and malignant primary spinal cord tumors and to estimate the survival rates for primary malignant spinal cord tumors.
  • METHODS: Incidence of spinal cord tumors was estimated from cases diagnosed between 1998 and 2002 in 16 CBTRUS collaborating state cancer registries.
  • SEER*Stat 6.1.4 software was used to estimate relative survival for malignant spinal cord tumors for cases diagnosed between 1975 and 2002 in nine SEER regions.
  • CONCLUSIONS: Of the spinal cord tumors identified (CBTRUS; n = 3,226), 69% were non-malignant.
  • The overall incidence of spinal cord tumors was 0.74 per 100,000 person-years, with an incidence of 0.77/100,000 in females and 0.70/100,000 in males.
  • The 1-, 5-, and 10-year survival rates following diagnosis of a primary malignant spinal cord tumor were 85%, 71%, and 64%, respectively (SEER; n = 1,220).
  • [MeSH-major] SEER Program. Spinal Cord Neoplasms / epidemiology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. African Continental Ancestry Group. Age Distribution. Aged. Aged, 80 and over. Child. Child, Preschool. European Continental Ancestry Group. Female. Hispanic Americans. Humans. Incidence. Infant. Infant, Newborn. Male. Middle Aged. Sex Distribution

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  • (PMID = 18084720.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Peng L, Qi ST, Chen Z, Fen WF, Fang LX, Huang LJ, Cheng JP: Radical microsurgical treatment of intramedullary spinal cord tumors. Chin Med J (Engl); 2006 Aug 20;119(16):1343-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radical microsurgical treatment of intramedullary spinal cord tumors.
  • BACKGROUND: The surgical treatment of intramedullary spinal cord tumor aims at complete removal and minimal postoperative deficit.
  • This study was undertaken to evaluate the microsurgical features of intramedullary spinal cord tumors and the time for surgery and prognosis.
  • METHODS: Twenty-one patients with intramedullary spinal cord tumor who had been treated at Nanfang Hospital, Guangzhou, China since 2000 were studied retrospectively.
  • Thirteen patients had the tumor in the cervical segments, 4 in medulla-cervical segments, 1 in cervicothoracic segment, and 3 in thoracic spine.
  • All the patients underwent microsurgery for the tumor through posterior approaches by laminectomy.
  • The tumor was exposed through dorsal myelotomy, then tumor plane was removed carefully from the entire rostrocaudal area.
  • In case of tumors occupying too many spinal segments, titanium strip was applied to reconstruct the vertebral plate and keep the spinal column stable.
  • RESULTS: Complete removal of the tumor was made in 15 patients, subtotal removal in 5, and partial resection in 1.
  • The dissection interface between the tumor and normal cord tissue was the most important factor influencing the extent of surgical removal.
  • CONCLUSIONS: Intramedullary spinal cord tumor mostly take place in cervical segments, with glioma as the commonest type.
  • Microsurgery is the major treatment of choice, by which tumor plane could be totally resected.
  • Excellent microsurgical expertise and careful recognition of tumor plane are essential to removal of the tumor while retaining neurological functions.
  • We underscore the importance of early diagnosis and radical microsurgical treatment of intramedullary spinal cord tumor.
  • [MeSH-major] Microsurgery / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae. Child. Child, Preschool. Female. Glioma / radiography. Glioma / surgery. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 16934179.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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27. Sun JJ, Wang ZY, Xie JC, Li ZD, Ma CC, Liu B, Zhao JZ: [Comparative analysis between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas]. Beijing Da Xue Xue Bao; 2010 Apr 18;42(2):183-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comparative analysis between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas].
  • OBJECTIVE: To comparatively analyze the different and common points between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas, such as the patient's age, gender, nervous functions and tumor location, longitudinal extension, and removed extent.
  • METHODS: Data were studied from 12 patients with multi-segments intramedullary spinal cord congenital tumors and 19 patients with multi-segments intramedullary spinal cord benign ependymomas who underwent microsurgery for the tumor using a posterior approach.
  • The tumor was exposed through dorsal myelotomy.
  • Two independent sample Mann-Whitney tests was performed for the patient's gender, stool and urine functions, limbs weakness, and tumor removed extent in the two groups.
  • Those located at the conus accounted for almost 83.3% (10/12) multi-segments intramedullary spinal cord congenital tumors.
  • Because of the stiff adhesion with adjacent neural structures or penetrative growth in surrounding spinal marrow, some congenital tumors could not totally removed by force.
  • 78.9 (15/19) percent of multi-segments intramedullary spinal cord benign ependymomas were located at the cervical and cervicothoracic segments.
  • CONCLUSION: It is known from the clinical files that most multi-segments intramedullary spinal cord congenital tumors are found in young patients and most benign ependymomas in the middle-aged.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / congenital. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Microsurgery / methods. Neurosurgical Procedures / methods. Teratoma / congenital. Teratoma / diagnosis. Teratoma / surgery. Young Adult

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  • (PMID = 20396361.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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28. Simon SL, Auerbach JD, Garg S, Sutton LN, Telfeian AE, Dormans JP: Efficacy of spinal instrumentation and fusion in the prevention of postlaminectomy spinal deformity in children with intramedullary spinal cord tumors. J Pediatr Orthop; 2008 Mar;28(2):244-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of spinal instrumentation and fusion in the prevention of postlaminectomy spinal deformity in children with intramedullary spinal cord tumors.
  • Postlaminectomy spinal deformity is a frequent problem after resection of a pediatric spinal cord tumor.
  • However, the use of spinal fusion done at the time of resection in preventing the development of deformity is unknown.
  • The purpose of our study was to assess the effectiveness of single-stage laminectomy, spinal cord decompression, and fusion for the prevention of postlaminectomy spinal deformity in children with intramedullary spinal cord tumors.
  • Clinical charts and radiographs of 33 children with spinal cord tumors were reviewed for treatment description, preoperative spinal alignment, postoperative spinal alignment, and subsequent medical and surgical treatment.
  • Spinal deformity was graded by predefined criteria.
  • Significant spinal deformity developed in 10 of 17 children with laminectomy only, 3 of 4 children with laminoplasty, and 3 of 12 children with spinal fusion (2/6 with instrumentation, 1/6 with in situ fusion).
  • Excluding patients that progressed to paraplegia, 9 of 16 patients treated with resection without fusion compared with 1 of 10 patients treated with resection and fusion developed a spinal deformity (P = 0.04).
  • Removal of greater than 4 laminae (P = 0.03) was found to be associated with the development of postresection spinal deformity.
  • [MeSH-major] Laminectomy / adverse effects. Postoperative Complications / prevention & control. Spinal Cord Neoplasms / surgery. Spinal Diseases / prevention & control. Spinal Fusion / methods
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Infant. Male. Severity of Illness Index

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  • (PMID = 18388723.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Guppy KH, Akins PT, Moes GS, Prados MD: Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis. J Neurosurg Spine; 2009 Jun;10(6):557-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis.
  • Oligodendroglioma of the spinal cord is a rare tumor that most often presents with spinal cord symptoms.
  • The authors present a case of spinal cord oligodendroglioma that was associated with cerebral rather than spinal cord symptoms.
  • The biopsy findings revealed an abnormal arachnoid thickening without tumor cells.
  • Cerebrospinal fluid cytological findings were negative for tumor cells or infection.
  • She was found to have a cervical cord lesion at C3-4 that was initially nonenhancing but later enhanced after Gd administration.
  • Biopsy of the cord lesion with partial resection showed a WHO Grade II oligodendroglioma with 1p and 19q deletions determined by fluorescence in situ hybridization.
  • Neurooncological treatment with tumor radiation and temozolomide (Temodor) resulted in improvement in radiographic findings, symptoms, and long-term survival.
  • This paper presents an extensive review of the literature, which revealed only 2 other reported cases of cerebral symptoms in adults that preceded spinal cord symptoms in a patient with oligodendroglioma of the spinal cord.
  • It is also the first reported case of oligodendrogliomatosis due to a cervical spinal cord oligodendroglioma with 1p and 19q deletions.
  • [MeSH-major] Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 19. Gene Deletion. Oligodendroglioma / genetics. Spinal Cord Neoplasms / genetics
  • [MeSH-minor] Adult. Cerebrospinal Fluid Shunts. Female. Humans. Hydrocephalus / pathology. Hydrocephalus / surgery. Magnetic Resonance Imaging. Reoperation

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  • (PMID = 19558288.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Hyun SJ, Rhim SC: Combined motor and somatosensory evoked potential monitoring for intramedullary spinal cord tumor surgery: correlation of clinical and neurophysiological data in 17 consecutive procedures. Br J Neurosurg; 2009 Aug;23(4):393-400

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined motor and somatosensory evoked potential monitoring for intramedullary spinal cord tumor surgery: correlation of clinical and neurophysiological data in 17 consecutive procedures.
  • We prospectively evaluated whether the combined use of somatosensory- and motor-evoked potential (SEP/MEP) for intramedullary spinal cord tumor (IMSCT) surgery may be beneficial.
  • [MeSH-major] Evoked Potentials, Motor / physiology. Evoked Potentials, Somatosensory / physiology. Monitoring, Intraoperative / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Anesthesia, Intravenous. Electric Stimulation. Female. Humans. Hypesthesia / prevention & control. Intraoperative Complications / diagnosis. Male. Middle Aged. Paresis / epidemiology. Paresis / prevention & control. Postoperative Complications / diagnosis. Prospective Studies. Sensitivity and Specificity. Treatment Outcome. Young Adult

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  • (PMID = 19637010.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Shintaku M, Nagata N, Itoh H: Tanycytic ependymoma of the spinal cord with anaplastic cytological features. Brain Tumor Pathol; 2009;26(1):7-10
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  • [Title] Tanycytic ependymoma of the spinal cord with anaplastic cytological features.
  • In a 43-year-old man, an intramedullary spinal cord tumor spreading from the level of the T2 to T5 vertebrae was subtotally resected.
  • The tumor predominantly consisted of a fascicular proliferation of spindle cells having bland nuclei and bipolar, long cytoplasmic processes, and a few perivascular pseudo-rosettes were found.
  • This is the first documentation of tanycytic ependymoma in which tumor cells showed anaplastic cytological features.
  • [MeSH-major] Ependymoma / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Anaplasia / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / immunology. Magnetic Resonance Imaging. Male

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  • (PMID = 19408091.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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32. Tobias ME, McGirt MJ, Chaichana KL, Goldstein IM, Kothbauer KF, Epstein F, Jallo GI: Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst; 2008 Feb;24(2):219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of long intramedullary spinal cord tumors.
  • OBJECT: Spinal cord tumors represent approximately 10-20% of primary central nervous system tumors.
  • MATERIALS AND METHODS: We retrospectively reviewed all patients undergoing surgical resection of longitudinally extensive intramedullary spinal cord tumors involving the majority of the spinal cord between 1990 and 2002.
  • One (8%) patient died from progression of anaplastic oligodendroglioma, and two (15%) underwent reoperation for recurrent tumor (ganglioglioma, grade II astrocytoma).
  • Five (38%) patients required fusion for progressive spinal deformity.
  • CONCLUSION: Gross total resection of holocord and longitudinally extensive intramedullary spinal cord tumors can be achieved with preservation of long-term neurological function in many cases.
  • Serial imaging is recommended to guide subsequent resection for tumor recurrence and stabilization of progressive spinal deformity.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae. Child. Child, Preschool. Female. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 17639420.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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33. Abuzallouf S, Wong R, Mintz AP, Provias J: Hemangioendothelioma of the spinal cord with intramedullary extension. Med Princ Pract; 2005 Sep-Oct;14(5):354-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemangioendothelioma of the spinal cord with intramedullary extension.
  • We report a rare case in the literature of intradural HE of the spinal cord with intramedullary extension.
  • Imaging revealed a spinal tumor causing complete blockage at the level of T12.
  • The tumor was resected and postoperative radiotherapy was delivered for residual disease.
  • [MeSH-major] Hemangioendothelioma / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Humans. Low Back Pain / etiology. Magnetic Resonance Imaging. Male. Radiotherapy, Adjuvant. Thoracic Vertebrae / pathology. Thoracic Vertebrae / radiography. Treatment Outcome

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  • (PMID = 16103703.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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34. Sahni D, Harrop JS, Kalfas IH, Vaccaro AR, Weingarten D: Exophytic intramedullary meningioma of the cervical spinal cord. J Clin Neurosci; 2008 Oct;15(10):1176-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exophytic intramedullary meningioma of the cervical spinal cord.
  • Intramedullary spinal cord neoplasms are relatively uncommon.
  • Meningiomas can occur as an intradural tumor; however, they are typically in the extramedullary compartment.
  • At surgery, it was noted that the tumor originated in the cervical spinal cord and extended into the extramedullary region.
  • Spinal meningiomas may occur in locations other than intradural, extramedullary locations, and should be included in the differential diagnosis of intramedullary lesions.
  • [MeSH-major] Meningioma / pathology. Spinal Cord Compression / etiology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Decompression, Surgical. Humans. Male. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 18710810.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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35. Taricco MA, Guirado VM, Fontes RB, Plese JP: Surgical treatment of primary intramedullary spinal cord tumors in adult patients. Arq Neuropsiquiatr; 2008 Mar;66(1):59-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of primary intramedullary spinal cord tumors in adult patients.
  • BACKGROUND: Primary spinal cord intramedullary tumors are rare and present with insidious symptoms.
  • The cervical cord was involved in 27% and thoracic in 42% of patients.
  • Ependymoma was the most frequent tumor (66.7%).
  • [MeSH-major] Cervical Vertebrae. Spinal Cord Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Treatment Outcome

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  • (PMID = 18392416.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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36. Horn EM, Nakaji P, Coons SW, Dickman CA: Surgical treatment for intramedullary spinal cord melanocytomas. J Neurosurg Spine; 2008 Jul;9(1):48-54

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  • [Title] Surgical treatment for intramedullary spinal cord melanocytomas.
  • Spinal meningeal melanocytomas are rare lesions that are histologically benign and can behave aggressively, with local infiltration.
  • The authors present their experience with intramedullary spinal cord melanocytomas consisting of 3 cases, which represents the second largest series in the literature.
  • A retrospective chart review was performed following identification of all spinal melanocytomas treated at the author's institution, based on information obtained from a neuropathology database.
  • The charts were reviewed for patient demographics, surgical procedure, clinical outcome, and long-term tumor progression.
  • Three patients were identified in whom spinal melanocytoma had been diagnosed between 1989 and 2006.
  • The patients' ages were 37, 37, and 48 years, and the location of their tumor was C1-3, T9-10, and T-12, respectively.
  • With these cases added to the available literature, the evidence strongly suggests that complete resection is the treatment of choice for spinal melanocytomas.
  • [MeSH-major] Nevus, Pigmented / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Cervical Vertebrae. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 18590410.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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37. Martínez-Lage JF, Ruiz-Espejo Vilar A, Almagro MJ, Sánchez del Rincón I, Ros de San Pedro J, Felipe-Murcia M, Murcia-García FJ: [Spinal cord tethering in myelomeningocele and lipomeningocele patients: the second operation]. Neurocirugia (Astur); 2007 Aug;18(4):312-9
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  • [Title] [Spinal cord tethering in myelomeningocele and lipomeningocele patients: the second operation].
  • BACKGROUND: Spinal cord rethetering can occur after the primary surgical repair of myelomeningoceles (MMC) and lipomeningoceles (LMC) and produce devastating physical and psychological consequences.
  • OBJECTIVES: To review the incidence of spinal cord tethering following surgery for open and occult spinal dysraphism and to analyze factors that might influence the appearance of this complication.
  • We also aimed to search technical measures at the time of the primary operation that might prevent the occurrence of symptomatic cord retethering.
  • MATERIAL AND METHODS: We reviewed the medical records of patients submitted to surgical repair of MMC (n=162) or occult spinal dysraphism (n= 54) during the period 1975-2005 who developed symptomatic tethered cord syndrome.
  • RESULTS: Eleven of 162 (6.79%) patients with MMC and 2 of 54 (3.7%) with LMC developed clinical symptoms and signs of spinal cord tethering after intervals ranging from 2 to 37 years after the initial surgical repair of their back lesions.
  • Interestingly, 3 of 162 (or 1.85%) myelomeningoceles were found to harbor an intradural epidermoid tumor at the time of spinal cord dethetering, accounting for an incidence of cutaneous inclusion tumors of 27% in cases of post- MMC repair tethering.
  • Early or late clinical deterioration can be due to spinal cord re-tethering and deserves timely investigation and surgical exploration.
  • We also report two infrequent causes of spinal cord deterioration: lumbar canal stenosis and intense foreign-body reactions to implanted materials.
  • [MeSH-major] Meningomyelocele / surgery. Reoperation. Spinal Cord / surgery. Spinal Dysraphism / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Lumbosacral Region. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Postoperative Complications. Retrospective Studies

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  • (PMID = 17882338.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 30
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38. Baek WS, Pytel P, Undevia SD, Rubeiz H: Spinal cord metastasis of a non-neurofibromatosis type-1 malignant peripheral nerve sheath tumor: an unusual manifestation of a rare tumor. J Neurooncol; 2005 Sep;74(2):183-5
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  • [Title] Spinal cord metastasis of a non-neurofibromatosis type-1 malignant peripheral nerve sheath tumor: an unusual manifestation of a rare tumor.
  • They arise from the spinal roots, peripheral nerves, brachial and lumbosacral plexi, cranial nerves and terminal nerve fibers within soft tissue, intestine, lung and bone.
  • Spinal cord metastasis from malignant nerve sheath tumors associated with neurofibromatosis type 1 is very rare.
  • We describe a rare case of near-total spinal cord metastasis in a patient with malignant nerve sheath tumor in the absence of neurofibromatosis, and highlight the microscopic findings and natural history of this disease process.
  • [MeSH-major] Lung Neoplasms / secondary. Nerve Sheath Neoplasms / pathology. Neurofibroma / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Benzenesulfonates / therapeutic use. Chemotherapy, Adjuvant. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Niacinamide / analogs & derivatives. Phenylurea Compounds. Pyridines / therapeutic use


39. Can M, Gul S, Bektas S, Hanci V, Acikgoz S: Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury. Acta Anaesthesiol Scand; 2009 Sep;53(8):1068-72
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  • [Title] Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury.
  • BACKGROUND: The aim of this study was to compare the anti-inflammatory response of methylprednisolone and the alpha2-agonist dexmedetomidine in spinal cord injury (SCI).
  • METHODS: Twenty-four male adult Wistar albino rats, weight 200-250 g, were included in the study.
  • Twenty-four hours after the trauma, spinal cord samples were taken for histopathological examination and serum samples were collected for interleukin-6 (IL-6) and tumor necrosis factor (TNF)-alpha measurement.
  • [MeSH-major] Analgesics, Non-Narcotic / pharmacology. Anti-Inflammatory Agents / pharmacology. Dexmedetomidine / pharmacology. Inflammation / prevention & control. Methylprednisolone / pharmacology. Spinal Cord Injuries / pathology
  • [MeSH-minor] Animals. Edema / pathology. Edema / prevention & control. Interleukin-6 / blood. Male. Neutrophil Infiltration / drug effects. Rats. Rats, Wistar. Tumor Necrosis Factor-alpha / blood

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  • (PMID = 19519725.001).
  • [ISSN] 1399-6576
  • [Journal-full-title] Acta anaesthesiologica Scandinavica
  • [ISO-abbreviation] Acta Anaesthesiol Scand
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Non-Narcotic; 0 / Anti-Inflammatory Agents; 0 / Interleukin-6; 0 / Tumor Necrosis Factor-alpha; 67VB76HONO / Dexmedetomidine; X4W7ZR7023 / Methylprednisolone
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40. Kurt G, Ergün E, Cemil B, Börcek AO, Börcek P, Gülbahar O, Ceviker N: Neuroprotective effects of infliximab in experimental spinal cord injury. Surg Neurol; 2009 Mar;71(3):332-6, discussion 336
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  • [Title] Neuroprotective effects of infliximab in experimental spinal cord injury.
  • BACKGROUND: The aim of the study is to assess the effects of infliximab, a TNF-alpha receptor blocker, in a spinal cord clip compression injury model.
  • METHODS: Clip compression injury model was used for producing spinal cord injury on 32 adult, male Wistar rats (Gazi University Animal Research Laboratory, Ankara, Turkey).
  • Spinal cord injury was performed on all rats with application of a 70-g closing force aneurysm clip for 1 minute.
  • All rats were killed 72 hours later, and the level of lipid peroxides in traumatized spinal cord tissue were measured as thiobarbituric acid-reactive material and determined using the method of Mihara and Uchiyama (Determination of malonaldehyde precursor in tissue by thiobarbituric acid test.
  • RESULTS: Treatment with infliximab and methylprednisolone decreased MDA levels in rats with spinal cord injury with a statistically significant difference.
  • CONCLUSIONS: Infliximab is found as effective as methylprednisolone on spinal cord clip compression injury.
  • [MeSH-major] Anti-Inflammatory Agents / pharmacology. Antibodies, Monoclonal / pharmacology. Neuroprotective Agents / pharmacology. Spinal Cord Compression / drug therapy
  • [MeSH-minor] Animals. Biomarkers / metabolism. Disease Models, Animal. Infliximab. Injections, Intraperitoneal. Lipid Peroxidation / drug effects. Male. Malondialdehyde / metabolism. Methylprednisolone / pharmacology. Rats. Rats, Wistar. Recovery of Function / drug effects. Thiobarbituric Acid Reactive Substances / metabolism. Tumor Necrosis Factor-alpha / antagonists & inhibitors

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  • (PMID = 18440605.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies, Monoclonal; 0 / Biomarkers; 0 / Neuroprotective Agents; 0 / Thiobarbituric Acid Reactive Substances; 0 / Tumor Necrosis Factor-alpha; 4Y8F71G49Q / Malondialdehyde; B72HH48FLU / Infliximab; X4W7ZR7023 / Methylprednisolone
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41. Schuurmans M, Vanneste JA, Verstegen MJ, van Furth WR: Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases. J Neurooncol; 2006 Aug;79(1):57-9
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  • [Title] Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases.
  • Magnetic resonance imaging (MRI) of the cervical spine revealed an extramedullary tumor with severe spinal cord compression.
  • During surgery an intradural extramedullary tumor was found.
  • Further imaging showed a second lumbar spinal tumor.
  • Two years after surgery, an intracranial extracerebral metastasis was found, without evidence of spinal recurrence.
  • [MeSH-major] Brain Neoplasms / secondary. Ependymoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Lumbar Vertebrae. Magnetic Resonance Imaging. S100 Proteins / metabolism

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  • [Cites] J Neurosurg. 2004 Jan;100(1 Suppl Spine):75-9 [14748579.001]
  • [Cites] Neurosurgery. 2000 Dec;47(6):1434-7; discussion 1437-8 [11126915.001]
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  • (PMID = 16614942.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / S100 Proteins
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42. Kanno H, Yamamoto I, Nishikawa R, Matsutani M, Wakabayashi T, Yoshida J, Shitara N, Yamasaki I, Shuin T, Clinical VHL Research Group in Japan: Spinal cord hemangioblastomas in von Hippel-Lindau disease. Spinal Cord; 2009 Jun;47(6):447-52
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  • [Title] Spinal cord hemangioblastomas in von Hippel-Lindau disease.
  • OBJECTIVE: To clarify the clinical features and surgical management of spinal cord hemangioblastomas in patients with von Hippel-Lindau disease (VHL).
  • METHODS: Forty-eight out of 66 patients with associated spinal cord hemangioblastoma among 142 VHL patients were retrospectively examined with respect to clinical features, accompanying lesions and outcome of surgical treatment.
  • Twenty-three patients (47.9%) had more than one spinal cord hemangioblastoma.
  • The 48 patients with spinal cord hemangioblastomas collectively had a total of 74 tumors.
  • The tumor was accompanied with a syrinx in 64 and without it in 10 patients.
  • Forty of the 48 patients underwent surgical treatment for their spinal cord hemangioblastomas, and 7 of these 40 underwent surgical treatment twice.
  • CONCLUSION: Von Hippel-Lindau disease patients bearing spinal cord hemangioblastomas mostly had a CNS hemangioblastoma at another site.
  • In these patients, when the timing of treatment for spinal cord hemangioblastoma is determined, the probability of occurrence and treatment of other lesions should be considered.
  • [MeSH-major] Hemangioblastoma / etiology. Hemangioblastoma / surgery. Spinal Cord Neoplasms / etiology. Spinal Cord Neoplasms / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Neurologic Examination. Retrospective Studies. Severity of Illness Index. Treatment Outcome. Young Adult

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  • (PMID = 19030009.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Investigator] Ibayashi Y; Yamaki T; Numagami Y; Jokura E; Kayama Y; Yamada Y; Shiokawa Y; Yamashita J; Hasegawa M; Hatano H; Shinoda J; Sakai N; Taki W; Matsushima S; Murao K; Matsubara T; Takahashi JA; Matsumoto K; Nakajima H; Hashimoto M; Matsumoto S; Ichigizaki K; Murase I; Kashiwabara K; Yamakawa Y; Yamazaki H; Kubo S; Tokuda K; Abiko S; Miyazaki H; Anda T; Shibata S; Miyamoto T; Okawa N; Morimoto S; Inoue M; Miyagami M
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43. Zorlu F, Ozyigit G, Gurkaynak M, Soylemezoglu F, Akyol F, Lale Atahan I: Postoperative radiotherapy results in primary spinal cord astrocytomas. Radiother Oncol; 2005 Jan;74(1):45-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postoperative radiotherapy results in primary spinal cord astrocytomas.
  • BACKGROUND AND PURPOSE: We retrospectively evaluated the therapeutic outcomes of patients with primary spinal cord astrocytomas treated with conventional radiotherapy at our institute.
  • PATIENTS AND METHODS: Between May 1975 and December 1997, 26 patients with histologically proven spinal cord astrocytomas were treated with conventional radiotherapy, and twenty-four eligible patients were evaluated.
  • Patients were treated with 1-2 Gy daily fractions, and given to a median total dose of 49.5 Gy (range 35-60 Gy) external radiotherapy to primary tumor.
  • [MeSH-major] Astrocytoma / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Male. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 15683668.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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44. Soares S, Barnat M, Salim C, von Boxberg Y, Ravaille-Veron M, Nothias F: Extensive structural remodeling of the injured spinal cord revealed by phosphorylated MAP1B in sprouting axons and degenerating neurons. Eur J Neurosci; 2007 Sep;26(6):1446-61
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  • [Title] Extensive structural remodeling of the injured spinal cord revealed by phosphorylated MAP1B in sprouting axons and degenerating neurons.
  • Spinal cord injury (SCI) results in loss of sensory and motor function because injured axons do not regenerate and neurons that die are not replaced.
  • The extent of morphological remodeling after spinal cord injury is, however, not understood.
  • We have previously shown that a phosphorylated form of microtubule-associated protein-1B, MAP1B-P, is expressed by growing axons, but is detected in intact adult SC in fibers exhibiting a somatotopic distribution of myelinated sensory fibers.
  • We now demonstrate that after adult SCI, MAP1B-P is up-regulated in other classes of axons.
  • We used immunohistochemistry to show changing levels and distributions of MAP1B-P after a right thoracic hemisection of adult rat spinal cord.
  • [MeSH-major] Axons / pathology. Microtubule-Associated Proteins / metabolism. Nerve Degeneration / pathology. Neurons / pathology. Spinal Cord Injuries / metabolism. Spinal Cord Injuries / pathology
  • [MeSH-minor] Animals. Cell Line, Tumor. Cells, Cultured. Female. Ganglia, Spinal / cytology. Immunohistochemistry. MAP Kinase Kinase 4 / metabolism. Nerve Fibers / pathology. Nerve Fibers / physiology. Phosphorylation. Rats. Rats, Wistar. Spinal Cord / cytology. Spinal Cord / metabolism. Spinal Cord / pathology

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  • (PMID = 17880387.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Microtubule-Associated Proteins; 0 / microtubule-associated protein 1B; EC 2.7.12.2 / MAP Kinase Kinase 4
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45. Volpp PB, Han K, Kagan AR, Tome M: Outcomes in treatment for intradural spinal cord ependymomas. Int J Radiat Oncol Biol Phys; 2007 Nov 15;69(4):1199-204

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes in treatment for intradural spinal cord ependymomas.
  • PURPOSE: Spinal cord ependymomas are rare tumors, accounting for <2% of all primary central nervous system tumors.
  • This study assessed the treatment outcomes for patients diagnosed with spinal cord ependymomas within the Southern California Kaiser Permanente system.
  • CONCLUSIONS: The results of our study indicate that en bloc gross total resection should be the initial treatment, with radiotherapy reserved primarily for postoperative cases with unfavorable characteristics such as residual tumor, anaplastic histologic features, or piecemeal resection.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Radiotherapy, Adjuvant. Salvage Therapy / methods. Survival Rate. Treatment Outcome

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  • (PMID = 17689025.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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46. Nakamura M, Chiba K, Ishii K, Ogawa Y, Takaishi H, Matsumoto M, Toyama Y: Surgical outcomes of spinal cord astrocytomas. Spinal Cord; 2006 Dec;44(12):740-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcomes of spinal cord astrocytomas.
  • OBJECTIVES: To analyze prognostic factors for patients with spinal cord astrocytomas.
  • Impacts of the tumor histological grade, the level of the tumor, the types of surgical interventions, and the use of adjuvant radiotherapies on the survival and functional outcomes of 30 patients (18 in low-grade and 12 high-grade malignancy tumors) were analyzed.
  • CONCLUSIONS: The tumor grade and the extent of tumor resection were significant prognostic factors for survival rate.
  • [MeSH-major] Astrocytoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • (PMID = 16670687.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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47. Scheinemann K, Bartels U, Huang A, Hawkins C, Kulkarni AV, Bouffet E, Tabori U: Survival and functional outcome of childhood spinal cord low-grade gliomas. Clinical article. J Neurosurg Pediatr; 2009 Sep;4(3):254-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival and functional outcome of childhood spinal cord low-grade gliomas. Clinical article.
  • OBJECT: Intramedullary spinal cord low-grade gliomas (LGGs) are rare CNS neoplasms in pediatric patients, and there is little information on therapy for and outcome of these tumors in this population.
  • Furthermore, most patient series combine adult and pediatric patients or high- and low-grade tumors, resulting in controversial data regarding optimal treatment of these children.
  • To clarify these issues, the authors performed a regional population-based study of spinal cord LGGs in pediatric patients.
  • RESULTS: Spinal cord LGGs in pediatric patients constituted 29 (4.6%) of 635 LGGs.
  • Epidemiological and clinical data in this cohort were different than in patients with other spinal tumors and strikingly similar to data from pediatric patients with intracranial LGGs.
  • Chemotherapy and radiation therapy showed similar efficacy, achieving sustained tumor control in most patients.
  • CONCLUSIONS: This study provides basic data on the incidence, clinical course, and outcome of spinal cord LGGs in pediatric patients.
  • The similarities between spinal and intracranial LGGs in pediatric patients showing excellent survival but high morbidity suggest that a less aggressive approach may be the preferable treatment option for these patients.
  • [MeSH-major] Glioma / mortality. Glioma / therapy. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / therapy

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  • (PMID = 19772410.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Tendulkar RD, Pai Panandiker AS, Wu S, Kun LE, Broniscer A, Sanford RA, Merchant TE: Irradiation of pediatric high-grade spinal cord tumors. Int J Radiat Oncol Biol Phys; 2010 Dec 01;78(5):1451-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Irradiation of pediatric high-grade spinal cord tumors.
  • PURPOSE: To report the outcome using radiation therapy (RT) for pediatric patients with high-grade spinal cord tumors.
  • METHODS AND MATERIALS: A retrospective chart review was conducted that included 17 children with high-grade spinal cord tumors treated with RT at St. Jude Children's Research Hospital between 1981 and 2007.
  • The tumor diagnosis was glioblastoma multiforme (n = 7), anaplastic astrocytoma (n = 8), or anaplastic oligodendroglioma (n = 2).
  • Local tumor progression at 12 months (79% vs. 30%, p = 0.02) and median survival (13.1 vs. 27.2 months, p = 0.09) were worse for patients with glioblastoma multiforme compared with anaplastic astrocytoma or oligodendroglioma.
  • CONCLUSIONS: High-grade spinal cord primary tumors in children have a poor prognosis.
  • [MeSH-major] Astrocytoma / radiotherapy. Oligodendroglioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease-Free Survival. Female. Glioblastoma / mortality. Glioblastoma / pathology. Glioblastoma / radiotherapy. Glioblastoma / surgery. Humans. Male. Prognosis. Radiotherapy Dosage. Retrospective Studies. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20346593.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Watanabe A, Horikoshi T, Naganuma H, Satoh E, Nukui H: Intramedullary spinal cord germinoma expresses the protooncogene c-kit. Acta Neurochir (Wien); 2005 Mar;147(3):303-8; discussion 308
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord germinoma expresses the protooncogene c-kit.
  • Magnetic resonance (MR) imaging demonstrated a mass with moderate and heterogeneous enhancement and peritumoural intramedullary cysts in the spinal cord at the T-1 to T-3 levels.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Germinoma / pathology. Proto-Oncogene Proteins c-kit / biosynthesis. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Neurosurgical Procedures. Paresis / etiology. Paresis / pathology. Paresis / physiopathology. Pregnancy. Pregnancy Complications, Neoplastic. Radiotherapy. Somatosensory Disorders / etiology. Somatosensory Disorders / pathology. Somatosensory Disorders / physiopathology. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 15662572.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 27
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50. Wang XW, Jian FZ, Yuan QG, Wang DM: [Minimally invasive surgery of the spinal cord hemangioblastoma]. Zhonghua Yi Xue Za Zhi; 2005 Jan 26;85(4):229-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Minimally invasive surgery of the spinal cord hemangioblastoma].
  • OBJECTIVE: To clarify and discuss the diagnosis and minimally invasive surgery of spinal cord hemangioblastoma.
  • METHODS: The clinical data of 16 patients with spinal cord hemangioblastoma who were operated on between 1992 and 2001 were analyzed retrospectively with a review of the literature.
  • RESULTS: Twelve patients were subjected to MRI examination, nine to spinal cord angiography, and six to preoperative embolization.
  • Thirteen patients underwent complete excision, and three underwent partial excision due to massive bleeding and anterior location of the tumor in spinal cord.
  • Eleven patients showed improvement of their symptoms, four no change at all, and tumor recurrence was seen in one patient with aggravation.
  • CONCLUSION: MRI and spinal angiography are essential for preoperative diagnosis and surgical planning.
  • [MeSH-major] Hemangioblastoma / surgery. Minimally Invasive Surgical Procedures. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Angiography. Female. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Middle Aged. Neurosurgical Procedures / methods. Spinal Cord / blood supply

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  • (PMID = 15854481.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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51. Barami K, Dagnew E: Endoscope-assisted posterior approach for the resection of ventral intradural spinal cord tumors: report of two cases. Minim Invasive Neurosurg; 2007 Dec;50(6):370-3
MedlinePlus Health Information. consumer health - Melanoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscope-assisted posterior approach for the resection of ventral intradural spinal cord tumors: report of two cases.
  • We report our experience with the removal of ventral intradural spinal tumors through a posterior approach with the assistance of an endoscope.
  • The endoscope allowed us to remove the tumor with minimal retraction of the spinal cord and to inspect for involvement of structures that were difficult to visualize with the microscope.
  • This is the second report of the utilization of the endoscope for removal of intradural spinal cord tumors.
  • Our data are discussed in the context of prior reported morphometric studies involving the spinal cord and expand the indications for the endoscope.
  • [MeSH-major] Dura Mater / surgery. Endoscopy / methods. Melanoma / surgery. Meningioma / surgery. Spinal Cord / pathology. Spinal Cord / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged, 80 and over. Cervical Vertebrae / anatomy & histology. Cervical Vertebrae / surgery. Female. Humans. Laminectomy / methods. Magnetic Resonance Imaging. Male. Neurosurgical Procedures / instrumentation. Neurosurgical Procedures / methods. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Thoracic Vertebrae / anatomy & histology. Thoracic Vertebrae / surgery. Treatment Outcome

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  • (PMID = 18210362.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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52. Tsitsopoulos P, Rizos C, Isaakidis D, Liapi G, Zymaris S: Coexistence of spinal intramedullary teratoma and diastematomyelia in an adult. Spinal Cord; 2006 Oct;44(10):632-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of spinal intramedullary teratoma and diastematomyelia in an adult.
  • STUDY DESIGN: A case report of intramedullary spinal cord teratoma with remote diastematomyelia in a female adult.
  • OBJECTIVE: To present a rare case of a dysembryogenic spinal tumor with concurrent split cord malformation and to define the importance of early surgical removal of the tumor.
  • She underwent plain radiographs, CT and MRI scan, which revealed an exophytic intramedullary spinal cord tumor at the level of T8-T10 and distant diastematomyelia in the upper lumbar spine (L2-L3).
  • The tumor was subtotally removed.
  • The histological examination demonstrated mature spinal teratoma consisting of ectodermal, mesodermal and endodermal elements.
  • CONCLUSIONS: In adult patients with intramedullary masses of possible dysembryogenic origin, the whole spine must be examined for additional dysraphic lesions.
  • [MeSH-major] Neural Tube Defects / complications. Spinal Cord Neoplasms / complications. Teratoma / complications
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 16389271.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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53. Chen CT, Foo NH, Liu WS, Chen SH: Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms. Pediatr Neonatol; 2008 Jun;49(3):77-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms.
  • BACKGROUND: Human umbilical cord blood cells (HUCBCs) were used to investigate the mechanisms underlying the beneficial effects of cord blood cells in spinal cord injury (SCI).
  • (2) Laminectomy+SCI+human adult peripheral blood mononucleocytes (PBMCs) (5 x 10(6)/0.3 mL); and (3) Laminectomy+SCi+HUCBCs (5 x 10(6)/0.3 mL).
  • SCI was induced by compressing the spinal cord for 1 minute with an aneurysm clip calibrated to 55 g closing pressure.
  • Serum levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-10, were assayed.
  • Furthermore, to determine if glial cell line-derived neurotrophic factor (GDNF) or vascular endothelial growth factor (VEGF) could be detected in the spinal cord injured area after systemic HUCBC infusion, analysis of these two molecules was conducted by immunofluorescence.
  • Both VEGF and GDNF could be detected in the injured spinal cord after transplantation of HUCBC, but not PBMC, cells.
  • [MeSH-major] Cord Blood Stem Cell Transplantation. Inflammation / prevention & control. Spinal Cord Injuries / therapy
  • [MeSH-minor] Animals. Glial Cell Line-Derived Neurotrophic Factor / analysis. Hindlimb / physiopathology. Humans. Immunohistochemistry. Interleukin-10 / blood. Motor Activity. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / blood. Vascular Endothelial Growth Factor A / blood

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  • (PMID = 18947003.001).
  • [ISSN] 1875-9572
  • [Journal-full-title] Pediatrics and neonatology
  • [ISO-abbreviation] Pediatr Neonatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Tumor Necrosis Factor-alpha; 0 / Vascular Endothelial Growth Factor A; 130068-27-8 / Interleukin-10
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54. Campos WK, Linhares MN: Sporadic intramedullary spinal cord hemangioblastoma in a newborn. Pediatr Neurosurg; 2010;46(5):385-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic intramedullary spinal cord hemangioblastoma in a newborn.
  • BACKGROUND: Hemangioblastomas (HB) are rare lesions accounting for 2% of all spinal cord tumors.
  • Spinal cord HB are usually diagnosed in adult patients and their incidence in early infancy is an extreme rarity.
  • MRI of the spine revealed an intramedullary tumor extending from level T6 to T12.
  • RESULTS: The tumor was excised completely, using standard microsurgical techniques via a posterior approach.
  • The histological diagnosis was spinal cord HB.
  • CONCLUSION: A review of the literature revealed that this neoplasm is composed of 3 major cell types: endothelial cells, pericytes and stromal cells.
  • Complete microsurgical removal is the treatment of choice for spinal cord HB because the tumor is benign.
  • To the best of our knowledge, sporadic spinal cord HB at this age has not been reported so far.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21389752.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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55. Rylova AV, Solenkova AV, Lubnin AIu, Salova EM: [Successful experience with xenon anesthesia in a patient with dilated cardiomyopathy and intramedullary spinal cord tumor]. Anesteziol Reanimatol; 2009 Nov-Dec;(6):54-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Successful experience with xenon anesthesia in a patient with dilated cardiomyopathy and intramedullary spinal cord tumor].
  • The paper describes the first case of xenon anesthesia in a patient with dilated cardiomyopathy with an ejection fraction of less than 30% and rapidly progressing spinal cord tumor.
  • [MeSH-major] Anesthesia, Inhalation. Anesthetics, Inhalation / administration & dosage. Cardiomyopathy, Dilated / complications. Spinal Cord Neoplasms / surgery. Xenon / administration & dosage
  • [MeSH-minor] Adult. Hemodynamics / drug effects. Humans. Male. Stroke Volume / drug effects

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  • (PMID = 20099650.001).
  • [ISSN] 0201-7563
  • [Journal-full-title] Anesteziologiia i reanimatologiia
  • [ISO-abbreviation] Anesteziol Reanimatol
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; 3H3U766W84 / Xenon
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56. Aoyama T, Hida K, Ishii N, Seki T, Ikeda J, Iwasaki Y: Intramedullary spinal cord germinoma--2 case reports. Surg Neurol; 2007 Feb;67(2):177-83; discussion 183
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord germinoma--2 case reports.
  • BACKGROUND: Primary intramedullary spinal cord germinoma is very rare.
  • We encountered 2 patients with primary intramedullary spinal cord germinoma.
  • We describe herein our comprehensive management system for CNS germinoma, including intramedullary spinal cord germinoma, along with a review of the literature.
  • Magnetic resonance imaging demonstrated marked cord swelling between T9 and T12, with slight enhancement in the spinal cord.
  • Astrocytic tumor was initially suspected, and partial removal was performed.
  • Magnetic resonance imaging demonstrated cord swelling between T8 and T10, with slight Gd-DTPA enhancement.
  • Because the lesion did not respond to steroid pulse therapy, spinal cord tumor was suspected and biopsy was performed.
  • CONCLUSION: Correct diagnosis of very rare primary intramedullary spinal cord germinoma is important, because these patients can be treated successfully using chemo- and radiotherapy without neurologic deterioration.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / therapy. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Chorionic Gonadotropin, beta Subunit, Human / analysis. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures. Paraparesis / etiology. Radiotherapy. Treatment Outcome. Urination Disorders / etiology

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  • (PMID = 17254883.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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57. Hargett C, Bassett T: Atypical presentation of sinus histiocytosis with massive lymphadenopathy as an epidural spinal cord tumor: a case presentation and literature review. J Spinal Disord Tech; 2005 Apr;18(2):193-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical presentation of sinus histiocytosis with massive lymphadenopathy as an epidural spinal cord tumor: a case presentation and literature review.
  • Less than 10 of the reported central nervous system tumors have presented as an epidural spinal cord tumor.
  • Magnetic resonance imaging of the thoracic spine revealed a tumor mass from T5 to T9.
  • The tumor was resected, and the spinal column was stabilized with pedicle screw fixation and fusion.
  • [MeSH-major] Epidural Neoplasms / pathology. Epidural Space / pathology. Histiocytosis, Sinus / pathology. Spinal Cord Neoplasms / pathology. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adult. Decompression, Surgical. Female. Humans. Laminectomy. Magnetic Resonance Imaging. Pain / etiology. Pain / pathology. Pain / radiography. Paraplegia / etiology. Paraplegia / pathology. Paraplegia / radiography. Paresis / physiopathology. Recurrence. Spinal Fusion. Treatment Outcome

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  • (PMID = 15800441.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Takahashi M, Koyama H, Matsubara T, Murata H, Miura K, Nagano A: Mixed germinoma and choriocarcinoma in the intramedullary spinal cord: case report and review of the literature. J Neurooncol; 2006 Jan;76(1):71-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed germinoma and choriocarcinoma in the intramedullary spinal cord: case report and review of the literature.
  • Primary germinomas in the spinal cord are very rare with only 15 cases published previously.
  • In this case a 22-year-old woman with urinary incontinence, lumbago, and bilateral leg pain and weakness was found to have a solid tumor in the conus medullaris between the L1 and L2 vertebral bodies.
  • The pathological diagnosis was mixed germinoma and choriocarcinoma of the intramedullary spinal cord.
  • To our knowledge, this is the first case report of a patient with a primary mixed germinoma and choriocarcinoma of the intramedullary spinal cord.
  • The previous 15 cases of primary spinal cord germinoma have been reviewed for comparison.
  • [MeSH-major] Choriocarcinoma / drug therapy. Choriocarcinoma / radiotherapy. Germinoma / drug therapy. Germinoma / radiotherapy. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Muscle Weakness / etiology. Pain / etiology. Treatment Outcome. Urinary Incontinence / etiology

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  • (PMID = 16132500.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Chacko AG, Daniel RT, Chacko G, Babu KS: Pial and arachnoid welding for restoration of normal cord anatomy after excision of intramedullary spinal cord tumors. J Clin Neurosci; 2007 Aug;14(8):764-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pial and arachnoid welding for restoration of normal cord anatomy after excision of intramedullary spinal cord tumors.
  • A significant postoperative problem in patients undergoing excision of intramedullary tumors is painful dysesthesiae, attributed to various causes, including edema, arachnoid scarring and cord tethering.
  • The authors describe a technique of welding the pia and arachnoid after the excision of intramedullary spinal cord tumors used in seven cases.
  • Closing the pia and arachnoid restores normal cord anatomy after tumor excision and may reduce the incidence of postoperative painful dysesthesiae.
  • [MeSH-major] Arachnoid / surgery. Pia Mater / surgery. Spinal Cord Neoplasms / surgery. Welding / methods
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Postoperative Complications. Retrospective Studies. Spinal Cord / anatomy & histology. Ultrasonography, Doppler / methods

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  • (PMID = 17532219.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Technical Report
  • [Publication-country] Scotland
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60. Lei P, Wu Y, Li ZY, Wang Y: Microsurgical resection of tumors lateroventral and ventral to the high cervical spinal cord. Chin Med J (Engl); 2005 May 20;118(10):828-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical resection of tumors lateroventral and ventral to the high cervical spinal cord.
  • BACKGROUND: Since there are a complex anatomic structure and vital function in the high cervical spinal cord, it is difficult to remove the tumors lateroventral and ventral to the high cervical spinal cord.
  • This clinical study was undertaken to analyze surgical approaches, manner of tumor resection and postoperative management.
  • METHODS: Thirty-four patients underwent microsurgical excision of tumors lateroventral and ventral to the high cervical spinal cord by means of three approaches.
  • Tumor volume varied from 3.0 cm x 2.5 cm x 2.0 cm to 12 cm x 3.0 cm x 2.5 cm.
  • Of the 34 patients, 4 had dumbbell-shaped tumors growing outside the spinal canal and 7 tumors growing into the intracranium.
  • RESULTS: The tumor was totally removed in 32 patients (94.1%).
  • CONCLUSION: Modified operative approaches and microsurgical techniques can raise the rate of total tumor removal and reduce the disability of patients.
  • [MeSH-major] Meningioma / surgery. Microsurgery. Neurilemmoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / etiology

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  • (PMID = 15989763.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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61. Che XM, Xu QW, Shou JJ, Gu SX, Zhang MG, Sun B, Cui DM: [The diagnosis and surgical management for intramedullary spinal cord cavernous angioma]. Zhonghua Yi Xue Za Zhi; 2008 May 20;88(19):1306-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The diagnosis and surgical management for intramedullary spinal cord cavernous angioma].
  • OBJECTIVE: The clinical diagnosis and surgical management of intramedullary spinal cord cavernous angioma were discussed.
  • RESULT: All the 19 patients pathologically diagnosed with spinal cord cavernous angioma got good surgical results, besides one patient showed loss of proprioception.
  • CONCLUSION: The clinical symptom of most of the patients with spinal cord cavernous angioma presented mildly at onset, but deteriorated gradually because of repeated prehemorrhage.
  • Dissection should be done between the tumor and the gliosis during the surgical procedure, special attention should be paid to avoiding tumor residual.
  • It was not necessary to aggressively evacuate the hematoma derived from tumor hemorrhage, which extended along the central canal up and down, except obvious occupied syndrome exited.
  • [MeSH-major] Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 18956697.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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62. Yamagata T, Takami T, Tsuyuguchi N, Goto T, Wakasa K, Ohata K: Primary intramedullary spinal cord germinoma: diagnostic challenge and treatment strategy. Neurol Med Chir (Tokyo); 2009 Mar;49(3):128-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intramedullary spinal cord germinoma: diagnostic challenge and treatment strategy.
  • Two patients presented with primary intramedullary spinal cord germinoma (PISCG).
  • Neither diagnosis was correct at initial evaluation, and both underwent surgical verification of the tumor.
  • [MeSH-major] Germinoma / diagnosis. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Paraplegia / etiology. Radiotherapy / methods. Sensation Disorders / etiology. Treatment Outcome. Urinary Incontinence / etiology. Young Adult

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  • (PMID = 19318740.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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63. Zhao H, Zhu Y, Qiu GX, Zhang JG, Tian Y, Li SG: [Single-stage posterior vertebrectomy with reconstruction in treatment of spinal tumor]. Zhonghua Yi Xue Za Zhi; 2009 Mar 10;89(9):597-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Single-stage posterior vertebrectomy with reconstruction in treatment of spinal tumor].
  • OBJECTIVE: To investigate the feasibility and clinical significance of single-stage posterior vertebrectomy with reconstruction for the treatment of spinal tumor.
  • METHODS: Twenty-six consecutive patients with spinal tumor, 5 with giant cell tumor, 6 with metastatic tumor of breast cancer, 8 with metastatic tumor of lung cancer, 2 with plasmacytoma, 3 with metastatic tumor of renal carcinoma, and 2 with lymphoma, 12 males and 14 females, aged 49 (20-74), underwent single-stage posterior vertebrectomy through bilateral transpedicular route via posterior midline approach.
  • 11 patients with functional disorders of spinal cord or nerves (Frankel grade D) preoperatively showed improvement to Frankel grade E postoperatively.
  • CONCLUSION: A safe and effective technique for the treatment of spinal tumor, single-stage posterior vertebrectomy with reconstruction fully decompresses the neurological structures, corrects kyphosis, and achieves early weight-bearing, thus significantly improving the quality of life of the patients with spinal tumor.
  • [MeSH-major] Decompression, Surgical / methods. Orthopedic Procedures. Reconstructive Surgical Procedures. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19595158.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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64. Choi CY, Adler JR, Gibbs IC, Chang SD, Jackson PS, Minn AY, Lieberson RE, Soltys SG: Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord. Int J Radiat Oncol Biol Phys; 2010 Oct 1;78(2):499-506
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  • [Title] Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord.
  • PURPOSE: As the spinal cord tolerance often precludes reirradiation with conventional techniques, local recurrence within a previously irradiated field presents a treatment challenge.
  • METHODS AND MATERIALS: We retrospectively reviewed 51 lesions in 42 patients treated from 2002 to 2008 whose spinal metastases recurred in a previous radiation field (median previous spinal cord dose of 40 Gy) and were subsequently treated with stereotactic radiosurgery (SRS).
  • RESULTS: SRS was delivered to a median marginal dose of 20 Gy (range, 10-30 Gy) in 1-5 fractions (median, 2), targeting a median tumor volume of 10.3 cm(3) (range, 0.2-128.6 cm(3)).
  • Converting the SRS regimens with the linear quadratic model (α/β = 3), the median spinal cord maximum single-session equivalent dose (SSED) was 12.1 Gy(3) (range, 4.7-19.3 Gy(3)).
  • CONCLUSION: SRS is safe and effective in the treatment of spinal metastases recurring in previously irradiated fields.
  • Tumor recurrence within 12 months may correlate with biologic aggressiveness and require higher SRS doses (SSED >15 Gy(10)).
  • Further research is needed to define the partial volume retreatment tolerance of the spinal cord and the optimal target dose.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Radiation Tolerance. Radiosurgery / methods. Spinal Cord / radiation effects. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Female. Follow-Up Studies. Humans. Linear Models. Male. Middle Aged. Radiotherapy Dosage. Retreatment. Retrospective Studies. Survival Rate. Tumor Burden. Young Adult

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20133079.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Makuria AT, Henderson FC, Rushing EJ, Hartmann DP, Azumi N, Ozdemirli M: Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor. J Neurooncol; 2007 Apr;82(2):199-205
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  • [Title] Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor.
  • We report pathologic findings of an unusual spinal cord tumor from a 33-year-old male patient which showed hybrid features of oligodendroglioma and extraventricular neurocytoma.
  • Histologic examination revealed a clear cell neoplasm containing ganglion-like cells and calcifications, prompting the differential diagnosis of oligodendroglioma and extraventricular neurocytoma.
  • The proliferation index (using antibody MIB1) of the tumor was approximately 30%.
  • [MeSH-major] Neurocytoma / pathology. Oligodendroglioma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 17039400.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Deng C, Gorrie C, Hayward I, Elston B, Venn M, Mackay-Sim A, Waite P: Survival and migration of human and rat olfactory ensheathing cells in intact and injured spinal cord. J Neurosci Res; 2006 May 15;83(7):1201-12
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  • [Title] Survival and migration of human and rat olfactory ensheathing cells in intact and injured spinal cord.
  • Increasing evidence indicates the potential of olfactory ensheathing cells (OECs) for treating spinal cord injuries.
  • The present study compared proliferation and migration of adult rat and human OECs transplanted into the spinal cord of athymic (immunodeficient) rats.
  • After OEC injection into the thoracic spinal cord, animals were perfused 4 hr, 24 hr, and 7 days later.
  • Cells were seen leaving the injection site after 4 hr, and by 7 days both rat and human OECs had migrated approximately 1 mm rostrally and caudally within the cord (rat: 1,400 +/- 241 microm rostral, 1,134 +/- 262 microm caudal, n = 5; human: 1,337 +/- 192 microm rostral, 1,205 +/- 148 microm caudal, n = 6).
  • In 10 animals, the spinal cord was injured by a contralateral hemisection made 5 mm rostral to the transplantation site at the time of OEC transplantation.
  • In the injured cord, rat and human OECs migrated for shorter distances, in both rostral and caudal directions (rat: 762 +/- 118 microm rostral, 554 +/- 142 microm caudal, n = 4; human: 430 +/- 55 microm rostral, 399 +/- 161 microm caudal, n = 3).
  • The results show that rat and human OECs rapidly stop dividing after transplantation and have a similar ability to survive and migrate within the spinal cord of immunocompromised hosts.
  • [MeSH-major] Neuroglia / physiology. Olfactory Mucosa / physiology. Spinal Cord / physiology. Spinal Cord Injuries / therapy
  • [MeSH-minor] Animals. Biomarkers / metabolism. Cell Differentiation / physiology. Cell Division / physiology. Cell Movement / physiology. Cell Survival / physiology. Ectodysplasins. Female. Humans. Immunocompromised Host / physiology. Macrophages / cytology. Macrophages / physiology. Male. Membrane Proteins / metabolism. Proliferating Cell Nuclear Antigen / metabolism. Rats. Rats, Nude. Rats, Sprague-Dawley. Tissue Transplantation / methods. Tumor Necrosis Factors / metabolism

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16498634.001).
  • [ISSN] 0360-4012
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / EDA protein, human; 0 / Ectodysplasins; 0 / Membrane Proteins; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Necrosis Factors
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67. Lee CH, Moon KY, Chung CK, Kim HJ, Chang KH, Park SH, Jahng TA: Primary intradural extramedullary melanoma of the cervical spinal cord: case report. Spine (Phila Pa 1976); 2010 Apr 15;35(8):E303-7
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  • [Title] Primary intradural extramedullary melanoma of the cervical spinal cord: case report.
  • OBJECTIVE: We report a case of primary intradural extramedullary melanoma of the cervical spinal cord in a nonwhite patient.
  • Primary malignant melanoma of the spinal cord is a rare disease entity that predominately affects the middle or lower thoracic spine.
  • RESULTS: A standard posterior midline approach was used under the impression that the subacute subdural hematoma was caused by a hidden vascular anomaly or a rare, intradural, pigmented tumor.
  • CONCLUSION: Unlike most cases of primary intradural melanoma, this patient presented with unusual radiologic findings in the cervical spinal cord.
  • The case described in the present study illustrates that primary spinal cord melanoma is rare and must be diagnosed with caution due to its variable clinical and radiologic presentation.
  • [MeSH-major] Melanoma / pathology. Melanoma / therapy. Spinal Cord Compression / etiology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Activities of Daily Living. Adult. Asian Continental Ancestry Group. Biomarkers, Tumor. Combined Modality Therapy. Decompression, Surgical. Diagnosis, Differential. Drug Therapy. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Muscle Weakness / etiology. Neurosurgical Procedures. Paresthesia / etiology. Positron-Emission Tomography. Radiotherapy. Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord / surgery. Treatment Outcome

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  • (PMID = 20308942.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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68. Thariat J, Castelli J, Chanalet S, Marcie S, Mammar H, Bondiau PY: CyberKnife stereotactic radiotherapy for spinal tumors: value of computed tomographic myelography in spinal cord delineation. Neurosurgery; 2009 Feb;64(2 Suppl):A60-6
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  • [Title] CyberKnife stereotactic radiotherapy for spinal tumors: value of computed tomographic myelography in spinal cord delineation.
  • OBJECTIVE: For para- and intraspinal tumors, precise spinal cord delineation is critical for CyberKnife (Accuray, Inc., Sunnyvale, CA) stereotactic radiotherapy.
  • We evaluated whether computed tomographic (CT) myelography is superior to magnetic resonance imaging (MRI) for accurate spinal cord delineation.
  • The contrast between cerebrospinal fluid and spinal cord was excellent with CT myelography.
  • The mean gross tumor volume was 51.1 mL.
  • The mean prescribed dose was 34 Gy in 4 fractions (range, 2-7 fractions) with 147 beams (range, 79-232 beams) to the 75% reference isodose line (range, 68-80%), covering 95% (range, 86-99%) of the gross tumor volume with a mean conformity index of 1.4 (range, 1.1-1.8).
  • No short-term toxicity on the spinal cord was noted at 1- to 6-months of follow-up.
  • CONCLUSION: CT myelography was more accurate for spinal cord delineation than 3D-fast imaging employing steady-state acquisition MRI (used for its myelographic effect), particularly in the presence of ferromagnetic artifacts in heavily pretreated patients or in patients with severe spinal compression.
  • Because other MRI sequences (T2 and gadolinium-enhanced T1) provide excellent tumor characterization, we suggest trimodality imaging for spinal tumor treatment to yield submillimetric delineation accuracy.
  • Combined with CyberKnife technology, CT myelography can improve the feasibility of dose escalation or reirradiation of spinal tumors in selected patients, thereby increasing local control while avoiding myelopathy.
  • [MeSH-major] Myelography / methods. Radiosurgery. Radiotherapy Planning, Computer-Assisted / methods. Spinal Neoplasms / radionuclide imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 19165075.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Makary R, Wolfson D, Dasilva V, Mohammadi A, Shuja S: Intramedullary mature teratoma of the cervical spinal cord at C1-2 associated with occult spinal dysraphism in an adult. Case report and review of the literature. J Neurosurg Spine; 2007 Jun;6(6):579-84
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  • [Title] Intramedullary mature teratoma of the cervical spinal cord at C1-2 associated with occult spinal dysraphism in an adult. Case report and review of the literature.
  • There is a well-recognized association between dysontogenetic tumors of the spinal cord (including teratomas and enterogenous cysts) and dysraphic congenital spinal malformations.
  • The authors present a case of an adult with an intramedullary mature teratoma (IMMT) at the level of C1-2 of the cord associated with dysraphic congenital spinal malformations.
  • Intramedullary mature teratomas of the cervical region of the spinal cord are very rare in adults; only four such lesions have been reported, two of which involved upper cervical segments.
  • Despite the potentially critical location of the tumor, monitored microsurgery resulted in complete removal of the tumor with an intact surrounding capsule, associated fibrous tract, and ellipse of skin with a central dimple.
  • [MeSH-major] Spinal Cord Neoplasms / complications. Spinal Dysraphism / complications. Teratoma / complications

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  • (PMID = 17561750.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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70. Jin R, Rock J, Jin JY, Janakiraman N, Kim JH, Movsas B, Ryu S: Single fraction spine radiosurgery for myeloma epidural spinal cord compression. J Exp Ther Oncol; 2009;8(1):35-41
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  • [Title] Single fraction spine radiosurgery for myeloma epidural spinal cord compression.
  • It has been demonstrated that spine radiosurgery can be safely used for treatment of spine metastasis with rapid and durable pain control, but without detrimental effects to the spinal cord.
  • This study was carried out to determine the role of single fraction radiosurgery for epidural spinal cord compression due to multiple myeloma.
  • A total of 31 lesions in 24 patients with multiple myeloma, who presented with epidural spinal cord compression, were treated with spine radiosurgery.
  • Single fraction radiation dose of 10-18 Gy (median of 16 Gy) was administered to the involved spine including the epidural or paraspinal tumor.
  • Primary endpoints of this study were pain control, neurological improvement, and radiographic tumor control.
  • Complete radiographic response of the epidural tumor was noted in 81% at 3 months after radiosurgery.
  • Single fraction radiosurgery achieved an excellent clinical and radiographic response of myeloma epidural spinal cord compression.
  • [MeSH-major] Multiple Myeloma / complications. Radiosurgery / methods. Spinal Cord Compression / surgery. Spine / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Epidural Space. Female. Humans. Male. Middle Aged

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  • (PMID = 19827269.001).
  • [ISSN] 1359-4117
  • [Journal-full-title] Journal of experimental therapeutics & oncology
  • [ISO-abbreviation] J. Exp. Ther. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Manitt C, Wang D, Kennedy TE, Howland DR: Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury. J Neurosci Res; 2006 Dec;84(8):1808-20
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  • [Title] Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury.
  • Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS.
  • To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats.
  • This lesion targets spinal commissural projections, which respond to netrin-1 during development.
  • The dominant expression of UNC5H on axons and neurons in the spinal cord after injury and the persistent expression of netrin-1 by oligodendrocytes surrounding the lesion are consistent with the hypothesis that netrin-1 is a myelin-associated inhibitor of axonal regeneration after spinal cord injury.
  • [MeSH-major] Gene Expression Regulation / physiology. Nerve Growth Factors / metabolism. Receptors, Cell Surface / metabolism. Spinal Cord Injuries / metabolism. Spinal Cord Injuries / physiopathology. Tumor Suppressor Proteins / metabolism

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  • (PMID = 16998900.001).
  • [ISSN] 0360-4012
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Nerve Growth Factors; 0 / Receptors, Cell Surface; 0 / Tumor Suppressor Proteins; 0 / netrin receptors; 158651-98-0 / netrin-1
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72. Sung KS, Sung SK, Choi HJ, Song YJ: Spinal intradural extramedullary mature cystic teratoma in an adult. J Korean Neurosurg Soc; 2008 Nov;44(5):334-7

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  • [Title] Spinal intradural extramedullary mature cystic teratoma in an adult.
  • Spinal intradural extramedullary teratoma is a rare condition that develops more commonly in children than in adults and may be associated with spinal dysraphism.
  • We report a rare case of adult-onset intradural extramedullary teratoma in the thoracolumbar spinal cord with no evidence of spinal dysraphism and without the history of prior spinal surgery.
  • The resected tumor was histopathologically diagnosed as a mature cystic teratoma.

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  • (PMID = 19119471.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2612572
  • [Keywords] NOTNLM ; Mature teratoma / Spinal cord neoplasm
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73. Harrington JF, Messier AA, Levine A, Szmydynger-Chodobska J, Chodobski A: Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury. J Neurotrauma; 2005 Aug;22(8):919-28
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  • [Title] Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury.
  • In a number of stress conditions, the biological effects of tumor necrosis factor-alpha (TNF-alpha), such as the induction of neuronal apoptosis, are presumably attenuated by the soluble fragments of TNF receptors (sTNFRs).
  • Within 1 h after spinal cord injury, increased synthesis and/or secretion of TNF-alpha is detectable at the injury site.
  • However, the shedding of ectodomains of TNFRs in the traumatized spinal cord has not yet been reported.
  • In the present study, adult Sprague-Dawley rats were subjected to acute spinal cord injury (ASCI) by applying a 25-g Walsh-Tator aneurysm clip at the C8-T1 level.
  • The spinal cord tissue was analyzed by immunohistochemistry for the expression of TNF-alpha, TNFR1, and TNFR2, and by the TUNEL technique for the occurrence of neuronal death.
  • [MeSH-major] Apoptosis / physiology. Nerve Degeneration / physiopathology. Receptors, Tumor Necrosis Factor, Type I / metabolism. Spinal Cord / metabolism. Spinal Cord Injuries / cerebrospinal fluid. Tumor Necrosis Factor-alpha / metabolism
  • [MeSH-minor] Animals. Caspase 3. Caspases / metabolism. Cerebrospinal Fluid / chemistry. Cerebrospinal Fluid / metabolism. Disease Models, Animal. Female. Rats. Rats, Sprague-Dawley. Receptors, Tumor Necrosis Factor, Type II / metabolism. Time Factors. Up-Regulation / physiology

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  • (PMID = 16083358.001).
  • [ISSN] 0897-7151
  • [Journal-full-title] Journal of neurotrauma
  • [ISO-abbreviation] J. Neurotrauma
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS39921; United States / NINDS NIH HHS / NS / NS49479
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Tumor Necrosis Factor, Type I; 0 / Receptors, Tumor Necrosis Factor, Type II; 0 / Tumor Necrosis Factor-alpha; EC 3.4.22.- / Casp3 protein, rat; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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74. Yao KC, McGirt MJ, Chaichana KL, Constantini S, Jallo GI: Risk factors for progressive spinal deformity following resection of intramedullary spinal cord tumors in children: an analysis of 161 consecutive cases. J Neurosurg; 2007 Dec;107(6 Suppl):463-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors for progressive spinal deformity following resection of intramedullary spinal cord tumors in children: an analysis of 161 consecutive cases.
  • OBJECT: Gross-total resection of pediatric intramedullary spinal cord tumors (IMSCTs) can be achieved in the majority of cases, with preservation of long-term neurological function.
  • However, progressive spinal deformity requiring subsequent fusion occurs in many cases.
  • It remains unknown which subgroups of patients have the greatest risk for progressive spinal deformity.
  • METHODS: Data for 161 patients undergoing resection of IMSCTs at a single institution were retrospectively collected and analyzed with regard to the development of progressive spinal deformity requiring fusion and patient functional status (based on the modified McCormick Scale [mMS] and Karnofsky Performance Scale [KPS]) by conducting telephone interviews corroborated by medical records.
  • The independent association of all clinical, radiographic, and operative variables to subsequent progressive spinal deformity was assessed using multivariate logistic regression analysis.
  • The tumor spanned a mean of six +/- three spinal levels.
  • A median of 9 years (range 1-21) after surgery, progressive spinal deformity requiring fusion developed in 43 patients (27%).
  • An age less than 13 years, preoperative scoliotic deformity (Cobb angle > 10 degrees), involvement of the thoracolumbar junction, and tumor-associated syrinx independently increased the odds of a postoperative progressive deformity requiring fusion 4.4-, 3.2-, 2.6-, and 3.4-fold, respectively (p < 0.05).
  • Symptoms lasting less than 1 month before resection decreased the odds of spinal deformity requiring fusion ninefold (p < 0.05).
  • CONCLUSIONS: Progressive spinal deformity requiring fusion occurred in 27% of children undergoing resection of an IMSCT and was associated with a decreased functional status.
  • Preoperative scoliotic deformity, an increasing number of resections, an age less than 13 years, tumor-associated syrinx, and surgery spanning the thoracolumbar junction increased the risk for progressive spinal deformity.
  • Patients possessing one or more of these characteristics should be monitored closely for progressive spinal deformity following surgery.
  • [MeSH-major] Neurosurgical Procedures / adverse effects. Postoperative Complications / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / surgery. Spinal Diseases / etiology
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Child. Child, Preschool. Disease Progression. Female. Humans. Infant. Laminectomy. Logistic Models. Male. Prognosis. Reoperation. Retrospective Studies. Risk Factors. Spinal Fusion

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  • [CommentIn] J Neurosurg. 2007 Dec;107(6 Suppl):460-2; discussion 462 [18154013.001]
  • (PMID = 18154014.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Mehta GU, Asthagiri AR, Bakhtian KD, Auh S, Oldfield EH, Lonser RR: Functional outcome after resection of spinal cord hemangioblastomas associated with von Hippel-Lindau disease. J Neurosurg Spine; 2010 Mar;12(3):233-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional outcome after resection of spinal cord hemangioblastomas associated with von Hippel-Lindau disease.
  • OBJECT: Spinal cord hemangioblastomas are a common protean manifestation of von Hippel-Lindau (VHL) disease and can be associated with significant morbidity.
  • To better define expected outcome and optimal management of these tumors in the context of this neoplasia syndrome, the authors analyzed the findings from patients with VHL disease who underwent resection of spinal cord hemangioblastomas.
  • METHODS: Consecutive patients with VHL disease who underwent surgery for spinal cord hemangioblastomas with > 6 months follow-up were included in the study.
  • RESULTS: One hundred eight patients (57 male, 51 female) underwent 156 operations for resection of 218 spinal cord hemangioblastomas.
  • CONCLUSIONS: Resection of symptomatic spinal cord hemangioblastomas is a safe and effective means of preserving neurological function in patients with VHL disease.
  • Tumor location (ventral or completely intramedullary) can be used to assess functional risk associated with surgery.
  • [MeSH-major] Hemangioblastoma / surgery. Spinal Cord / surgery. Spinal Cord Neoplasms / surgery. von Hippel-Lindau Disease / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Neurosurgical Procedures / methods. Postoperative Complications. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20192620.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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76. Robinson CG, Prayson RA, Hahn JF, Kalfas IH, Whitfield MD, Lee SY, Suh JH: Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord. Int J Radiat Oncol Biol Phys; 2005 Sep 1;63(1):91-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord.
  • PURPOSE: To determine survival and changes in neurologic function and Karnofsky performance status (KPS) in a series of patients treated for low-grade astrocytoma of the spinal cord during the past two decades.
  • METHODS: This study consisted of 14 patients with pathologically confirmed low-grade astrocytoma of the spinal cord who were treated between 1980 and 2003.
  • Neither overall survival nor progression-free survival was clearly correlated with any patient, tumor, or treatment factors.
  • CONCLUSION: Patients who undergo gross total resection of their tumor may be followed closely.
  • [MeSH-major] Astrocytoma / mortality. Spinal Cord Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Child, Preschool. Female. Humans. Karnofsky Performance Status. Laminectomy. Male. Middle Aged. Postoperative Complications / etiology. Radiotherapy / adverse effects. Survival Rate. Treatment Failure

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  • (PMID = 16111576.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M, Toyama Y, Chiba K: Surgical treatment of intramedullary spinal cord tumors: prognosis and complications. Spinal Cord; 2008 Apr;46(4):282-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of intramedullary spinal cord tumors: prognosis and complications.
  • OBJECTIVE: To evaluate our recent treatment strategy for intramedullary spinal cord tumors.
  • The tumor malignancy grade according to the WHO classification was astrocytoma grade I, 3; grade II, 8 (low-grade: 11 cases); grade III, 10; grade IV, 2 (high-grade: 12 cases).
  • CONCLUSIONS: Predictors of good surgical outcome for intramedullary spinal cord tumors were histological grades of the tumors, surgical margins, and neurological status of the patient before surgery.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae. Child. Child, Preschool. Cohort Studies. Female. Humans. Male. Middle Aged. Postoperative Complications. Retrospective Studies. Survival Rate. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 17909556.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Watanabe M, Sakai D, Yamamoto Y, Iwashina T, Sato M, Mochida J: Upper cervical spinal cord tumors: review of 13 cases. J Orthop Sci; 2009 Mar;14(2):175-81
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  • [Title] Upper cervical spinal cord tumors: review of 13 cases.
  • BACKGROUND: Clinical features of upper cervical spinal cord tumors are not clear because there have been too few published reports.
  • METHODS: We reviewed 13 patients who underwent surgery for an upper cervical spinal cord tumor.
  • Tumor recurrence was seen in three patients for reasons thought to be the same as tumors at other levels, being residual meningiomas lying ventral to the cord and extraforaminal neurinomas.
  • CONCLUSIONS: Spinal cord tumors in the upper cervical region tend to progress as dumbbell tumors.
  • As all the neurinomas had this shape (Eden type 2 or 3) at C1/2, this anatomy might favor progression to the extradural and extraforaminal spaces.However, it also allows total removal of the tumor via a posterior approach.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neurilemmoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Female. Follow-Up Studies. Humans. Laminectomy / methods. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 19337809.001).
  • [ISSN] 1436-2023
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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79. Sun J, Wang Z, Li Z, Liu B: Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors. J Clin Neurosci; 2009 May;16(5):666-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors.
  • We aimed to prospectively analyze correlations between clinical features and histological classification of multi-segment intramedullary spinal cord tumors (MSICTs), and the extent of microsurgical resection and functional outcomes.
  • Fifty-six patients with MSICTs underwent microsurgery for tumor removal using a posterior approach.
  • The tumor was exposed through a dorsal myelotomy.
  • Correlation analyses were performed between functional outcome (IJOA score) and histological features, age, tumor location, and the longitudinal extent of spinal cord involvement.
  • Gross total tumor removal was achieved in 33 cases (58%), subtotal resection in 4 (7%), and partial resection in 16 (28%).
  • The histological classification of the tumor was the most important factor influencing the extent of surgical removal (chi2=22.17, p=0.00).
  • [MeSH-major] Laminectomy / methods. Microsurgery / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neurologic Examination / methods. Outcome Assessment (Health Care). Prospective Studies. Spinal Cord / pathology. Spinal Cord / surgery. Young Adult

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  • (PMID = 19303302.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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80. Rodesch G, Gaillard S, Loiseau H, Brotchi J: Embolization of intradural vascular spinal cord tumors : report of five cases and review of the literature. Neuroradiology; 2008 Feb;50(2):145-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Embolization of intradural vascular spinal cord tumors : report of five cases and review of the literature.
  • INTRODUCTION: Spinal cord tumors (SCT) are best treated by surgery.
  • RESULTS: Intranidal deposition of the glue was successful in all four patients, resulting in significant devascularization of the tumor.
  • Surgery became possible in each case under improved conditions with minimal blood loss, thereby allowing total (four cases of hemangioblastomas) or subtotal (one case of paraganglioma) removal of the tumor.
  • Despite its solid aspect after deposition, glue does not hinder surgery but facilitates the manipulation and eradication of the tumor.
  • [MeSH-major] Embolization, Therapeutic. Spinal Cord / blood supply. Spinal Cord Neoplasms / therapy. Vascular Neoplasms / therapy
  • [MeSH-minor] Adult. Humans. Male. Middle Aged

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  • (PMID = 17932665.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 33
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81. Howard MJ, Liu S, Schottler F, Joy Snider B, Jacquin MF: Transplantation of apoptosis-resistant embryonic stem cells into the injured rat spinal cord. Somatosens Mot Res; 2005 Mar-Jun;22(1-2):37-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transplantation of apoptosis-resistant embryonic stem cells into the injured rat spinal cord.
  • Approximately one million cells were transplanted into the lesion site in the spinal cords of adult rats which had received moderate contusion injuries 9 days previously.
  • At the conclusion of the 6-week survival period, the spinal cords were examined.
  • These results suggest that transplanting KD3 ES cells, or apoptosis-resistant cells derived from the KD3 line, into the injured spinal cord does not improve locomotor recovery and can lead to tumor-like growth of cells, accompanied by increased debilitation, morbidity and mortality.
  • [MeSH-major] Apoptosis. Spinal Cord Injuries / pathology. Spinal Cord Injuries / therapy. Stem Cell Transplantation. Stem Cells / pathology
  • [MeSH-minor] Animals. Cell Division. Female. Graft Survival / physiology. Motor Activity. Proto-Oncogene Proteins c-bcl-2 / genetics. Rats. Rats, Long-Evans. Recovery of Function. Spinal Cord / pathology. Spinal Cord / physiology. Treatment Failure

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  • (PMID = 16191756.001).
  • [ISSN] 0899-0220
  • [Journal-full-title] Somatosensory & motor research
  • [ISO-abbreviation] Somatosens Mot Res
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS10892; United States / NINDS NIH HHS / NS / NS38577
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
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82. Woodworth GF, Chaichana KL, McGirt MJ, Sciubba DM, Jallo GI, Gokaslan Z, Wolinsky JP, Witham TF: Predictors of ambulatory function after surgical resection of intramedullary spinal cord tumors. Neurosurgery; 2007 Jul;61(1):99-105; discussion 105-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictors of ambulatory function after surgical resection of intramedullary spinal cord tumors.
  • BACKGROUND: Contemporary treatment of intramedullary spinal cord tumors (IMSCTs) involves radical or subtotal tumor resection with adjuvant radiation and/or chemotherapy, depending on the tumor's histological type and grade as well as the extent of resection.
  • Although previous research is limited, identifying reliable predictors of functional status after tumor resection would be clinically useful for perioperative modification strategies.
  • [MeSH-major] Gait Disorders, Neurologic / etiology. Gait Disorders, Neurologic / prevention & control. Outcome Assessment (Health Care) / methods. Risk Assessment / methods. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Risk Factors. Treatment Outcome

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  • (PMID = 17621024.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Liu ZH, Lee ST, Jung SM, Tu PH: Primary spinal angiosarcoma. J Clin Neurosci; 2010 Mar;17(3):387-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal angiosarcoma.
  • Neuroimaging showed a large dorsal extradural tumor compressing the spinal cord at the T11 level with bony destruction of the left foramen and posterior elements.
  • Spinal angiography revealed a hypervascular tumor in the left T11 region.
  • Successful preoperative endovascular embolization, laminectomy and removal of the tumor were performed.
  • [MeSH-major] Hemangiosarcoma. Spinal Neoplasms
  • [MeSH-minor] Adult. Embolization, Therapeutic / methods. Humans. Magnetic Resonance Imaging / methods. Male. Neurosurgical Procedures / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20074966.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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84. Karabekir HS, Balci C, Tokyol C: Primary spinal anaplastic ganglioglioma. Pediatr Neurosurg; 2006;42(6):374-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal anaplastic ganglioglioma.
  • Gangliogliomas of the spinal cord are very unusual and the anaplastic variant of these tumors is extremely rare.
  • In spinal anaplastic gangliogliomas, malignant changes (hypercellularity, vascular proliferation, necrosis, high numbers of mitotic figures) are typically evident in the glial element of the tumor.
  • Gangliogliomas can arise in any part of the central nervous system and the features of adult and pediatric cases differ significantly.
  • We describe the case of a pediatric patient who had a spinal anaplastic ganglioglioma extending from the T9 to the L3 level.
  • The tumor was partially resected with an ultrasonic aspirator, but the patient's neurological status deteriorated as a result and adjuvant radiotherapy did not resolve the deficit.
  • [MeSH-major] Ganglioglioma / pathology. Spinal Cord Neoplasms / pathology

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 17047418.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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85. Perez-Bouza A, Glaser T, Brüstle O: ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions. Brain Pathol; 2005 Jul;15(3):208-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions.
  • Microinjection of an antibody to myelin oligodendrocyte glycoprotein (MOG) and complement was employed to generate circumscribed areas of demyelination in the adult rat spinal cord.
  • The engrafted cells remained largely confined to the lesion site and showed no evidence of tumor formation up until 4 weeks after transplantation.
  • [MeSH-minor] Animals. Antibodies / toxicity. Cell Differentiation. Disease Models, Animal. Female. Immunohistochemistry. In Situ Hybridization. Mice. Microscopy, Electron, Transmission. Myelin Proteins. Myelin-Associated Glycoprotein / immunology. Myelin-Oligodendrocyte Glycoprotein. Oligodendroglia / cytology. Oligodendroglia / ultrastructure. Rats. Spinal Cord / pathology

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  • (PMID = 16196387.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibodies; 0 / Mog protein, mouse; 0 / Mog protein, rat; 0 / Myelin Proteins; 0 / Myelin-Associated Glycoprotein; 0 / Myelin-Oligodendrocyte Glycoprotein
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86. Yang S, Yang X, Hong G: Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors. Spine (Phila Pa 1976); 2009 Nov 15;34(24):2705-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors.
  • STUDY DESIGN: A retrospective study of microsurgical treatment of intramedullary spinal cord tumors (IMSCT) was conducted.
  • The optimum treatment of those tumors is controversial, with the recent advance, the operation of IMSCTs has became safer and total resection of most those tumor is possible.
  • METHODS: Data from 174 IMSCTs operated on in the last 20 years are analyzed retrospectively by the tumors' anatomic locations, histologic types, symptoms and signs, tumor removal rate, and operative outcomes.
  • RESULTS: In this group ependymoma was the commonest tumor (48.9%), the second most often seen being astrocytoma (35.6%).
  • Total resection of the tumor was possible in 60.9% of patients, subtotal resection in 17.2%, and partial resection in 13.8%.
  • On long-term follow-up there was improvement in 70.2%, no change in 19.5%, deterioration in 4%, tumor recurrence in 6.9%, with 6.3% of patients dying.
  • CONCLUSION: Most intramedullary spinal cord tumors need operative treatment as early as possible.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Aged. Child. Child, Preschool. Decompression, Surgical / methods. Disability Evaluation. Early Diagnosis. Female. Humans. Infant. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Outcome Assessment (Health Care). Pain / etiology. Paralysis / etiology. Retrospective Studies. Sensation Disorders / etiology. Treatment Outcome. Urinary Bladder, Neurogenic / etiology. Young Adult

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  • (PMID = 19910775.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Duprez TP, Jankovski A, Grandin C, Hermoye L, Cosnard G, Raftopoulos C: Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite. AJNR Am J Neuroradiol; 2008 Nov;29(10):1991-4
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  • [Title] Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite.
  • We assessed feasibility, safety, and timing of an original intraoperative MR procedure in 3 cases of resection of spinal cord glioma by using a clinical 3T MR system connected to an adjacent operating room in a design being coined "twin" or "dual" MR-operating room suite.
  • [MeSH-major] Image Enhancement / methods. Magnetic Resonance Imaging / methods. Operating Rooms / methods. Operating Rooms / organization & administration. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Belgium. Female. Humans. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 18617591.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Abdel-Wahab M, Etuk B, Palermo J, Shirato H, Kresl J, Yapicier O, Walker G, Scheithauer BW, Shaw E, Lee C, Curran W, Thomas T, Markoe A: Spinal cord gliomas: A multi-institutional retrospective analysis. Int J Radiat Oncol Biol Phys; 2006 Mar 15;64(4):1060-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord gliomas: A multi-institutional retrospective analysis.
  • PURPOSE: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas.
  • PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01).
  • [MeSH-major] Glioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Astrocytoma / mortality. Astrocytoma / radiotherapy. Astrocytoma / surgery. Child. Child, Preschool. Disease Progression. Ependymoma / mortality. Ependymoma / radiotherapy. Ependymoma / surgery. Female. Humans. Male. Middle Aged. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 16373081.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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89. Maranzano E, Trippa F, Pacchiarini D, Chirico L, Basagni ML, Rossi R, Bellavita R, Schiavone C, Italiani M, Muti M: Re-irradiation of brain metastases and metastatic spinal cord compression: clinical practice suggestions. Tumori; 2005 Jul-Aug;91(4):325-30
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  • [Title] Re-irradiation of brain metastases and metastatic spinal cord compression: clinical practice suggestions.
  • So, the number of cases with brain metastases and metastatic spinal cord compression has increased, as has the possibility of developing a recurrence in areas of the central nervous system already treated with radiotherapy.
  • The absence of extracranial disease was the most significant factor in conditioning survival, and maximum tumor diameter was the only variable associated with an increased risk of unacceptable acute and/or chronic neurotoxicity.
  • In general, the incidence of an "in-field" recurrence of spinal metastasis varies from 2.5-11% of cases and can occur 2-40 months after the first radiotherapy cycle.
  • Experimental data indicate that also the total dose of the first and second radiotherapy, interval to re-treatment, length of the irradiated spinal cord, and age of the treated animals influence the risk of radiation-induced myelopathy.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Brain Neoplasms / secondary. Cranial Irradiation / methods. Spinal Cord Compression / etiology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Bone Marrow / radiation effects. Dose Fractionation. Female. Humans. Incidence. Male. Middle Aged. Necrosis / etiology. Practice Guidelines as Topic. Radiation Injuries / etiology. Radiosurgery. Radiotherapy / adverse effects. Retreatment. Stereotaxic Techniques

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  • (PMID = 16277098.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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90. Chaichana KL, Pendleton C, Wolinsky JP, Gokaslan ZL, Sciubba DM: Vertebral compression fractures in patients presenting with metastatic epidural spinal cord compression. Neurosurgery; 2009 Aug;65(2):267-74; discussion 274-5
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  • [Title] Vertebral compression fractures in patients presenting with metastatic epidural spinal cord compression.
  • OBJECTIVE: Metastatic epidural spinal cord compression (MESCC) is a relatively common and debilitating complication of metastatic disease that often results in neurological deficits.
  • This was independent of age, preoperative ambulatory status, preoperative motor deficit, duration of preoperative symptoms, immediate postoperative motor deficit, and lytic tumor appearance.
  • [MeSH-major] Fractures, Compression / etiology. Spinal Cord Compression / etiology. Spinal Fractures / etiology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / secondary. Causality. Decompression, Surgical. Drug Therapy / statistics & numerical data. Epidural Space / pathology. Epidural Space / physiopathology. Epidural Space / surgery. Female. Humans. Laminectomy. Male. Middle Aged. Paralysis / etiology. Paralysis / prevention & control. Paralysis / surgery. Radiotherapy / statistics & numerical data. Regression Analysis. Retrospective Studies. Spinal Canal / pathology. Spinal Canal / radiography. Spinal Canal / surgery. Spine / pathology. Spine / physiopathology. Spine / surgery. Thoracic Vertebrae / pathology

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  • (PMID = 19625904.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Berhouma M, Bahri K, Houissa S, Zemmel I, Khouja N, Aouidj L, Jemel H, Khaldi M: [Management of intramedullary spinal cord tumors: surgical considerations and results in 45 cases]. Neurochirurgie; 2009 Jun;55(3):293-302

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of intramedullary spinal cord tumors: surgical considerations and results in 45 cases].
  • BACKGROUND AND PURPOSE: Intramedullary spinal cord tumors (IMSCT) are relatively rare neoplasms, accounting for less than 5% of all central nervous system tumors.
  • The cervical location of the tumor was the most common (20 cases).
  • Determinant predictors for a good outcome after surgery of IMSCT are histological type of lesion, total removal of the tumor and a satisfactory neurological status before surgery.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Biopsy. Child. Child, Preschool. Disease Progression. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Microsurgery. Middle Aged. Spinal Cord / pathology. Treatment Outcome

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  • (PMID = 18538355.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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92. Hamamoto Y, Kataoka M, Senba T, Uwatsu K, Sugawara Y, Inoue T, Sakai S, Aono S, Takahashi T, Oda S: Vertebral metastases with high risk of symptomatic malignant spinal cord compression. Jpn J Clin Oncol; 2009 Jul;39(7):431-4
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  • [Title] Vertebral metastases with high risk of symptomatic malignant spinal cord compression.
  • OBJECTIVE: To find vertebral metastases with high risk of symptomatic malignant spinal cord compression (MSCC), features of vertebral metastases caused motor deficits of the lower extremities were examined.
  • Assessed factors were age, sex, primary disease (lung, breast, digestive system and other cancer), lamina involvement, main level of tumor location and vertebral-body involvement.
  • [MeSH-major] Cervical Vertebrae / pathology. Spinal Cord Compression / etiology. Spinal Neoplasms / secondary. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19429929.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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93. Jacob JT, Cohen-Gadol AA, Scheithauer BW, Krauss WE: Intramedullary spinal cord gangliocytoma: case report and a review of the literature. Neurosurg Rev; 2005 Oct;28(4):326-9
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  • [Title] Intramedullary spinal cord gangliocytoma: case report and a review of the literature.
  • We present a case of intramedullary spinal gangliocytoma in a 19-year-old woman who presented with a long history of hyperhidrosis of the face and neck areas and intermittent pain of the hands.
  • The tumor involved the cervico-thoracic region of the spinal cord from C7-T3.
  • [MeSH-major] Ganglioneuroma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Hyperhidrosis / etiology. Neurosurgical Procedures. Pain / etiology

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  • (PMID = 15739067.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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94. Katoh N, Shirato H, Aoyama H, Onimaru R, Suzuki K, Hida K, Miyasaka K, Iwasaki Y: Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. J Neurooncol; 2006 May;78(1):63-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor.
  • PURPOSE: To retrospectively analyze the outcome of post-operative radiotherapy for spinal cord glioma with the emphasis on the hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumors.
  • MATERIALS AND METHODS: Forty-one patients with spinal cord glioma received post-operative radiotherapy between 1979 and 2003.
  • [MeSH-major] Dose Fractionation. Glioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Survival Analysis

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  • (PMID = 16314938.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Kwon JY, Chung KW, Park EK, Park SW, Choi BO: Charcot-Marie-Tooth 1A concurrent with schwannomas of the spinal cord and median nerve. J Korean Med Sci; 2009 Aug;24(4):763-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Charcot-Marie-Tooth 1A concurrent with schwannomas of the spinal cord and median nerve.
  • We identified Charcot-Marie-Tooth disease type 1A (CMT1A) in a family with schwannomas in the spinal cord and median nerve.
  • A schwannoma is a benign encapsulated tumor originating from a Schwann cell.
  • [MeSH-major] Charcot-Marie-Tooth Disease / diagnosis. Median Neuropathy / diagnosis. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Chromosomes, Human, Pair 17. Female. Genetic Predisposition to Disease. Humans. Magnetic Resonance Imaging. Male. Myelin Proteins / genetics. Pedigree

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  • (PMID = 19654968.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Myelin Proteins; 0 / PMP22 protein, human
  • [Other-IDs] NLM/ PMC2719205
  • [Keywords] NOTNLM ; Charcot-Marie-Tooth Disease / Neurilemmoma / PMP22 Duplication
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96. Hida K, Iwasaki Y, Seki T, Yano S: two-stage operation for resection of spinal cord astrocytomas: technical case report of three cases. Neurosurgery; 2006 Apr;58(4 Suppl 2):ONS-E373; discussion ONS-E373

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] two-stage operation for resection of spinal cord astrocytomas: technical case report of three cases.
  • OBJECTIVE AND IMPORTANCE: Surgery for excision of intramedullary spinal cord tumors without increasing neurological deficit is one of the more difficult operations in spinal surgery.
  • In particular, infiltrating astrocytomas without a clear cleavage between the tumor and normal spinal cord parenchyma are difficult to remove totally without producing additional neurological impairment.
  • CLINICAL PRESENTATION: Three cases of spinal cord astrocytomas were treated using a two-staged method.
  • A thin expanded polytetrafluoroethylene sheet was placed between the dorsal surface of the spinal cord and dura mater to prevent adhesions.
  • Two or 3 weeks after surgery, a second surgery was performed to remove the now exophytic tumor.
  • RESULTS: Magnetic resonance imaging scans showed exophytic extrusion of the tumor in all three cases before the second operation.
  • All three patients remain neurologically stable without evidence of tumor recurrence more than 3 years after surgery.
  • CONCLUSION: A two-stage operation may enhance the surgeon's ability to completely resect extensive low-grade spinal cord astrocytomas and, at the same time preserve neurological function.
  • [MeSH-major] Astrocytoma / surgery. Laminectomy / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Child. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Reoperation / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 16575295.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Rabo CS, Hashimoto N, Kagawa N, Fujita T, Hirayama R, Otsuki H, Kinoshita M, Yoshimine T: A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma. Brain Tumor Pathol; 2010 Oct;27(2):117-20
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  • [Title] A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma.
  • Spinal magnetic resonance imaging (MRI) revealed a solitary, well-defined intramedullary mass at the L1-L2 level typical of a primary spinal cord germinoma.
  • This article describes a rare case of simultaneously detected intracranial and intramedullary spinal cord germinoma and its possible etiopathology.
  • [MeSH-major] Germinoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Fluorodeoxyglucose F18. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Positron-Emission Tomography. Radiopharmaceuticals. Spinal Cord / pathology

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  • (PMID = 21046314.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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98. Porensky P, Muro K, Ganju A: Adult presentation of spinal dysraphism and tandem diastematomyelia. Spine J; 2007 Sep-Oct;7(5):622-6
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  • [Title] Adult presentation of spinal dysraphism and tandem diastematomyelia.
  • BACKGROUND CONTEXT: Diastematomyelia is a split-cord malformation often accompanied by other cord or column anomalies.
  • PURPOSE: To report on an adult patient with diastematomyelia and discuss the embryological basis and related developmental sequelae of this split-cord malformation.
  • METHODS: A summary of the management of a 54-year-old woman with recent clinical symptomatology related to an undiagnosed split-cord malformation is presented with accompanying literature review.
  • RESULTS: A rare adult presentation of diastematomyelia with accompanying intradural extramedullary epidermoid tumor was repaired with resection of the soft-tissue mass and excision of the fibro-osseous septum.
  • CONCLUSION: Initial presentation of diastematomyelia is rarely seen in adults; accompanying pathology includes scoliosis, tethered cord, and intradural tumors.
  • [MeSH-major] Epidermal Cyst / radiography. Neural Tube Defects / radiography. Spinal Dysraphism / radiography
  • [MeSH-minor] Age Factors. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Preoperative Care. Spinal Canal / pathology. Spinal Canal / radiography. Tomography, X-Ray Computed

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  • MedlinePlus Health Information. consumer health - Neural Tube Defects.
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  • (PMID = 17905326.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Gao B, Wang X: An extramedullary plasmacytoma originating from the thoracic spinal cord: magnetic resonance imaging findings. Case report. J Neurosurg Spine; 2007 Jan;6(1):57-9
MedlinePlus Health Information. consumer health - MRI Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An extramedullary plasmacytoma originating from the thoracic spinal cord: magnetic resonance imaging findings. Case report.
  • Extramedullary plasmacytoma (EMP) is a rare tumor.
  • The authors report a case of an EMP originating in the thoracic spinal cord.
  • [MeSH-major] Magnetic Resonance Imaging. Plasmacytoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Humans. Male. Thorax

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  • (PMID = 17233292.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Acharya S, Ratra GS: Posterior spinal cord compression: outcome and results. Spine (Phila Pa 1976); 2006 Aug 1;31(17):E574-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Posterior spinal cord compression: outcome and results.
  • STUDY DESIGN: Prospective, comparative study of neurologic outcome in patients with posterior extradural cord compression.
  • SUMMARY OF BACKGROUND DATA: Posterior cord compression is a relatively uncommon entity with not much literature published on it.
  • METHODS: Over a period of 5 years, 14 patients with extradural posterior cord compression with neurologic deficit were divided into two etiologic groups: 9 patients had Koch's and 5 had other pathologies.
  • RESULTS: While results of surgery in patients with Koch's were good, with 7 of the 9 patients showing full recovery, outcome in patients with compression due to other causes (tumor/pyogenic infection) was not very satisfactory even after adequate mechanical decompression, with 3 of the 5 cases remaining paraplegic even after surgery.
  • CONCLUSION: Posterior cord compression due to nontuberculous causes frequently mimics the picture of Koch's both clinically and radiologically.
  • [MeSH-major] Spinal Cord Compression / surgery
  • [MeSH-minor] Abscess / complications. Adolescent. Adult. Aged. Child. Child, Preschool. Decompression, Surgical. Female. Humans. Laminectomy. Lymphoma, Non-Hodgkin / complications. Male. Middle Aged. Neuroblastoma / complications. Paranasal Sinus Diseases / complications. Paraplegia / etiology. Paraplegia / physiopathology. Prospective Studies. Severity of Illness Index. Spinal Cord Diseases / complications. Treatment Outcome. Tuberculosis, Spinal / complications

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  • (PMID = 16924194.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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