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1. Gelabert-González M, García-Allut A, Martínez-Rumbo R: [Spinal meningiomas]. Neurocirugia (Astur); 2006 Apr;17(2):125-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal meningiomas].
  • OBJECTIVE: To present the incidence, clinical presentation, radiological features, localization, surgical techniques, and long term results of surgically treated spinal meningiomas.
  • PATIENTS AND METHODS: We review retrospectively 57 spinal meningiomas in 55 patients operated between January 1980 and June 2004.
  • Distribution along the spinal axis was 51 thoracic, 5 cervical and 1 lumbar.
  • CONCLUSIONS: Meningiomas account in our experience, the 46% of spinal cord tumours and account the 7.5% of all meningiomas.
  • Finally we concluded that magnetic resonance imaging is the best imaging technique for diagnosis and total tumour resection improved the surgical results of spinal meningiomas.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 16721479.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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2. Chamberlain MC: Temozolomide for recurrent low-grade spinal cord gliomas in adults. Cancer; 2008 Sep 1;113(5):1019-24
Hazardous Substances Data Bank. DACARBAZINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temozolomide for recurrent low-grade spinal cord gliomas in adults.
  • BACKGROUND: There is no standard therapy for surgery- and radiotherapy-resistant, recurrent, low-grade spinal cord gliomas.
  • Therefore, a retrospective study of temozolomide (TMZ) in adults with recurrent low-grade spinal cord gliomas with a primary objective of determining progression-free survival (PFS) was performed.
  • METHODS: Twenty-two patients (11 men and 11 women) aged 20 years to 55 years (median, 35 years) with recurrent spinal cord gliomas (World Health Organization grade 2 astrocytoma in 19 patients and oligoastrocytoma in 3 patients) were treated.
  • Time to tumor progression ranged from 2 months to 28 months (median, 14.5 months).
  • CONCLUSIONS: TMZ demonstrated modest efficacy with acceptable toxicity in this cohort of adult patients with recurrent low-grade spinal cord gliomas.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Dacarbazine / analogs & derivatives. Glioma / drug therapy. Spinal Cord Neoplasms / drug therapy
  • [MeSH-minor] Adult. Disease-Free Survival. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Retrospective Studies

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18615600.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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3. Taricco MA, Guirado VM, Fontes RB, Plese JP: Surgical treatment of primary intramedullary spinal cord tumors in adult patients. Arq Neuropsiquiatr; 2008 Mar;66(1):59-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of primary intramedullary spinal cord tumors in adult patients.
  • BACKGROUND: Primary spinal cord intramedullary tumors are rare and present with insidious symptoms.
  • The cervical cord was involved in 27% and thoracic in 42% of patients.
  • Ependymoma was the most frequent tumor (66.7%).
  • [MeSH-major] Cervical Vertebrae. Spinal Cord Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Treatment Outcome

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  • (PMID = 18392416.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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4. Brinar M, Rados M, Habek M, Poser CM: Enlargement of the spinal cord: inflammation or neoplasm? Clin Neurol Neurosurg; 2006 Mar;108(3):284-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Enlargement of the spinal cord: inflammation or neoplasm?
  • Intramedullary spinal tumours are uncommon lesions that can cause significant difficulties in the differential diagnosis between inflammatory diseases such as multiple sclerosis and acute disseminated encephalomyelitis, and vascular malformations or neoplasms.
  • We report five cases in which the history and the clinical symptoms suggested an inflammatory process of the spinal cord but the MRI characteristics were those of neoplastic lesions.
  • [MeSH-major] Astrocytoma / diagnosis. Encephalomyelitis, Acute Disseminated / diagnosis. Multiple Sclerosis / diagnosis. Myelitis / etiology. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [CommentIn] Clin Neurol Neurosurg. 2007 Dec;109(10):931-3 [17868981.001]
  • [CommentIn] Clin Neurol Neurosurg. 2006 Dec;108(8):811-2 [16793201.001]
  • (PMID = 16376015.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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5. Ak H, Ulu MO, Sar M, Albayram S, Aydin S, Uzan M: Adult intramedullary mature teratoma of the spinal cord: review of the literature illustrated with an unusual example. Acta Neurochir (Wien); 2006 Jun;148(6):663-9; discussion 669
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult intramedullary mature teratoma of the spinal cord: review of the literature illustrated with an unusual example.
  • In this manuscript the authors have reviewed the adult intramedullary lesions of the spinal cord published in the literature that are harbouring the characteristics of a mature teratoma and analysed the results with respect to histopathology, epidemiology, diagnostic methods and treatment.
  • [MeSH-major] Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / physiopathology. Teratoma / diagnosis. Teratoma / physiopathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Decompression, Surgical. Diagnosis, Differential. Female. Germ Layers / pathology. Humans. Laminectomy. Male. Middle Aged. Neck Pain / diagnosis. Neck Pain / etiology. Neck Pain / physiopathology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / radiotherapy. Neurosurgical Procedures. Paraparesis / diagnosis. Paraparesis / etiology. Paraparesis / physiopathology. Radiotherapy / standards. Sensation Disorders / diagnosis. Sensation Disorders / etiology. Sensation Disorders / physiopathology. Spinal Canal / pathology. Spinal Canal / surgery. Treatment Outcome

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  • (PMID = 16523223.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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6. Armstrong PA, Polley LS: Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia. Int J Obstet Anesth; 2010 Jan;19(1):91-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia.
  • We report a case of an asymptomatic spinal cord neoplasm detected during the placement of a 25-gauge Whitacre spinal needle for spinal anesthesia before elective cesarean delivery.
  • Subarachnoid blood was repeatedly aspirated during otherwise uncomplicated induction of spinal anesthesia.
  • Magnetic resonance imaging revealed a spinal cord ependymoma in the lumbar spine.
  • Asymptomatic spinal cord neoplasms and ependymomas are reviewed.
  • [MeSH-major] Anesthesia, Obstetrical. Anesthesia, Spinal. Ependymoma / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Pregnancy. Subarachnoid Space / physiology. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19700305.001).
  • [ISSN] 1532-3374
  • [Journal-full-title] International journal of obstetric anesthesia
  • [ISO-abbreviation] Int J Obstet Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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7. Gill M, Pathak HC, Madan R, Bhattacharya S, Choudhary GS: Primary spinal pleomorphic xanthoastrocytoma. Neurol India; 2010 Sep-Oct;58(5):771-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal pleomorphic xanthoastrocytoma.
  • Pleomorphic xanthochromic astrocytoma primarily of the spinal cord is a rare entity.
  • [MeSH-major] Astrocytoma / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Complex and Mixed. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Magnetic Resonance Imaging. Young Adult

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  • (PMID = 21045509.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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8. Sung KS, Sung SK, Choi HJ, Song YJ: Spinal intradural extramedullary mature cystic teratoma in an adult. J Korean Neurosurg Soc; 2008 Nov;44(5):334-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal intradural extramedullary mature cystic teratoma in an adult.
  • Spinal intradural extramedullary teratoma is a rare condition that develops more commonly in children than in adults and may be associated with spinal dysraphism.
  • We report a rare case of adult-onset intradural extramedullary teratoma in the thoracolumbar spinal cord with no evidence of spinal dysraphism and without the history of prior spinal surgery.
  • The resected tumor was histopathologically diagnosed as a mature cystic teratoma.

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  • [Cites] Br J Neurosurg. 2000 Oct;14(5):482-8 [11198778.001]
  • [Cites] J Neurosurg Spine. 2007 Jun;6(6):579-84 [17561750.001]
  • [Cites] J Spinal Disord Tech. 2006 May;19(3):213-6 [16770222.001]
  • [Cites] Acta Neurochir (Wien). 2006 Jun;148(6):663-9; discussion 669 [16523223.001]
  • [Cites] Spinal Cord. 2002 Jan;40(1):40-3 [11821970.001]
  • [Cites] J Neurosurg. 1998 Nov;89(5):844-51 [9817426.001]
  • [Cites] Surg Neurol. 1995 May;43(5):466-9; discussion 469-70 [7660285.001]
  • [Cites] Surg Neurol. 1984 Sep;22(3):267-72 [6463837.001]
  • [Cites] Neurocirugia (Astur). 2004 Jun;15(3):290-3 [15239016.001]
  • [Cites] Neurosurgery. 1999 Aug;45(2):379-85 [10449085.001]
  • (PMID = 19119471.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2612572
  • [Keywords] NOTNLM ; Mature teratoma / Spinal cord neoplasm
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9. Tobias ME, McGirt MJ, Chaichana KL, Goldstein IM, Kothbauer KF, Epstein F, Jallo GI: Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst; 2008 Feb;24(2):219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of long intramedullary spinal cord tumors.
  • OBJECT: Spinal cord tumors represent approximately 10-20% of primary central nervous system tumors.
  • MATERIALS AND METHODS: We retrospectively reviewed all patients undergoing surgical resection of longitudinally extensive intramedullary spinal cord tumors involving the majority of the spinal cord between 1990 and 2002.
  • One (8%) patient died from progression of anaplastic oligodendroglioma, and two (15%) underwent reoperation for recurrent tumor (ganglioglioma, grade II astrocytoma).
  • Five (38%) patients required fusion for progressive spinal deformity.
  • CONCLUSION: Gross total resection of holocord and longitudinally extensive intramedullary spinal cord tumors can be achieved with preservation of long-term neurological function in many cases.
  • Serial imaging is recommended to guide subsequent resection for tumor recurrence and stabilization of progressive spinal deformity.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae. Child. Child, Preschool. Female. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 17639420.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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10. Cheng JN, Lawrentschuk N, Gyomber D, Rogerson J, Bolton DM: Cystectomy in patients with spinal cord injury: indications and long-term outcomes. J Urol; 2010 Jul;184(1):92-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystectomy in patients with spinal cord injury: indications and long-term outcomes.
  • PURPOSE: We evaluated indications and outcomes of cystectomy in patients with spinal cord injury in a urology unit attached to a statewide spinal cord injury service.
  • MATERIALS AND METHODS: We performed a review of all patients with spinal cord injury in our database who underwent cystectomy between 1997 and 2008.
  • RESULTS: Of 2,569 acute spinal cord injury presentations there were 14 patients who underwent cystectomy.
  • CONCLUSIONS: In patients with spinal cord injury cystectomy is performed almost as often for nonmalignant as for malignant indications.
  • Centers treating patients with spinal cord injury should consider a lower threshold for the surgical management of bladder cancer where appropriate, especially considering that morbidity, satisfaction and outcome do not appear to be compromised in patients with spinal cord injury.
  • [MeSH-major] Cystectomy / methods. Spinal Cord Injuries / complications. Urinary Bladder Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. BCG Vaccine / administration & dosage. Female. Humans. Length of Stay / statistics & numerical data. Male. Middle Aged. Neoplasm Recurrence, Local. Patient Satisfaction. Postoperative Complications / epidemiology. Quality of Life. Smoking / epidemiology. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20478600.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCG Vaccine
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11. Ramirez C, Delrieu O, Mineo JF, Paradot G, Allaoui M, Dubois F, Blond S: Intracranial dissemination of primary spinal cord anaplastic oligodendroglioma. Eur J Neurol; 2007 May;14(5):578-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial dissemination of primary spinal cord anaplastic oligodendroglioma.
  • We support a hypothesis whereby the anaplastic parts of tumors have spread along the spinal cord and brainstem via the cerebrospinal fluid pathways, a process that could be promoted by surgical manipulation, although the relative contribution of the two factors remains speculative.
  • [MeSH-major] Brain Neoplasms / secondary. Neoplasm Metastasis / physiopathology. Oligodendroglioma / secondary. Spinal Cord Neoplasms / pathology. Subarachnoid Space / physiopathology
  • [MeSH-minor] Adult. Cerebellar Neoplasms / secondary. Fatal Outcome. Humans. Hydrocephalus / etiology. Hydrocephalus / physiopathology. Hydrocephalus / therapy. Lateral Ventricles / pathology. Lateral Ventricles / physiopathology. Male. Neurosurgical Procedures / adverse effects

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  • (PMID = 17437621.001).
  • [ISSN] 1468-1331
  • [Journal-full-title] European journal of neurology
  • [ISO-abbreviation] Eur. J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Horn EM, Nakaji P, Coons SW, Dickman CA: Surgical treatment for intramedullary spinal cord melanocytomas. J Neurosurg Spine; 2008 Jul;9(1):48-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment for intramedullary spinal cord melanocytomas.
  • Spinal meningeal melanocytomas are rare lesions that are histologically benign and can behave aggressively, with local infiltration.
  • The authors present their experience with intramedullary spinal cord melanocytomas consisting of 3 cases, which represents the second largest series in the literature.
  • A retrospective chart review was performed following identification of all spinal melanocytomas treated at the author's institution, based on information obtained from a neuropathology database.
  • The charts were reviewed for patient demographics, surgical procedure, clinical outcome, and long-term tumor progression.
  • Three patients were identified in whom spinal melanocytoma had been diagnosed between 1989 and 2006.
  • The patients' ages were 37, 37, and 48 years, and the location of their tumor was C1-3, T9-10, and T-12, respectively.
  • With these cases added to the available literature, the evidence strongly suggests that complete resection is the treatment of choice for spinal melanocytomas.
  • [MeSH-major] Nevus, Pigmented / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Cervical Vertebrae. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 18590410.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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13. Shin DA, Kim SH, Kim KN, Shin HC, Yoon DH: Surgical management of spinal cord haemangioblastoma. Acta Neurochir (Wien); 2008 Mar;150(3):215-20; discussion 220

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of spinal cord haemangioblastoma.
  • BACKGROUND: The surgical management of spinal cord haemangioblastomas is distinct from that of other benign spinal cord tumours and optimal surgical strategy is still being determined because of the rarity of the condition.
  • PATIENTS AND METHODS: We retrospectively analysed 24 operations for symptomatic spinal cord haemangioblastomas in 20 patients.
  • CONCLUSION: The cystic component of spinal cord haemangioblastomas is responsible for symptom generation and is helpful for dissecting tumours.
  • [MeSH-major] Hemangioblastoma / surgery. Neurosurgical Procedures / methods. Spinal Cord / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiography. Electrocoagulation / methods. Electrocoagulation / standards. Female. Humans. Intraoperative Complications / prevention & control. Magnetic Resonance Imaging. Male. Middle Aged. Monitoring, Physiologic / methods. Neoplasm Recurrence, Local / prevention & control. Paresis / etiology. Paresis / physiopathology. Preoperative Care / methods. Recovery of Function / physiology. Retrospective Studies. Sensation Disorders / etiology. Sensation Disorders / physiopathology. Treatment Outcome

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  • (PMID = 18253694.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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14. Volpp PB, Han K, Kagan AR, Tome M: Outcomes in treatment for intradural spinal cord ependymomas. Int J Radiat Oncol Biol Phys; 2007 Nov 15;69(4):1199-204

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes in treatment for intradural spinal cord ependymomas.
  • PURPOSE: Spinal cord ependymomas are rare tumors, accounting for <2% of all primary central nervous system tumors.
  • This study assessed the treatment outcomes for patients diagnosed with spinal cord ependymomas within the Southern California Kaiser Permanente system.
  • CONCLUSIONS: The results of our study indicate that en bloc gross total resection should be the initial treatment, with radiotherapy reserved primarily for postoperative cases with unfavorable characteristics such as residual tumor, anaplastic histologic features, or piecemeal resection.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Radiotherapy, Adjuvant. Salvage Therapy / methods. Survival Rate. Treatment Outcome

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  • (PMID = 17689025.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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15. Nakamura M, Chiba K, Ishii K, Ogawa Y, Takaishi H, Matsumoto M, Toyama Y: Surgical outcomes of spinal cord astrocytomas. Spinal Cord; 2006 Dec;44(12):740-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcomes of spinal cord astrocytomas.
  • OBJECTIVES: To analyze prognostic factors for patients with spinal cord astrocytomas.
  • Impacts of the tumor histological grade, the level of the tumor, the types of surgical interventions, and the use of adjuvant radiotherapies on the survival and functional outcomes of 30 patients (18 in low-grade and 12 high-grade malignancy tumors) were analyzed.
  • CONCLUSIONS: The tumor grade and the extent of tumor resection were significant prognostic factors for survival rate.
  • [MeSH-major] Astrocytoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • (PMID = 16670687.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Gille O, Pointillart V, Vital JM: Course of spinal solitary osteochondromas. Spine (Phila Pa 1976); 2005 Jan 1;30(1):E13-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Course of spinal solitary osteochondromas.
  • STUDY DESIGN: Six spinal solitary osteochondromas.
  • OBJECTIVES: To evaluate the course of spinal cord compression after surgery, and the risk of local recurrence and malignant transformation, based on the present series and cases reported in the literature.
  • SUMMARY OF BACKGROUND DATA: Spinal cord compression by a solitary osteochondroma is rare.
  • Little is known concerning neurologic improvement after decompression of the spinal cord or the risk of recurrence or malignant transformation of spinal solitary osteochondroma, because most of the cases reported are isolated.
  • The literature was reviewed for solitary osteochondroma with spinal cord compromise, recurrent solitary osteochondroma, or solitary osteochondroma in the process of sarcomatous transformation.
  • RESULTS: In the present study, two of the six patients experienced spinal cord compromise.
  • Including these two patients, the authors found 62 cases of solitary osteochondroma with spinal cord compromise in the literature.
  • CONCLUSIONS: Surgical treatment improves neurologic deficit in more than 80% of cases of spinal cord compromise caused by solitary osteochondroma.
  • [MeSH-major] Osteochondroma / surgery. Spinal Cord Compression / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Risk Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15626967.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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17. Campos WK, Linhares MN: Sporadic intramedullary spinal cord hemangioblastoma in a newborn. Pediatr Neurosurg; 2010;46(5):385-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic intramedullary spinal cord hemangioblastoma in a newborn.
  • BACKGROUND: Hemangioblastomas (HB) are rare lesions accounting for 2% of all spinal cord tumors.
  • Spinal cord HB are usually diagnosed in adult patients and their incidence in early infancy is an extreme rarity.
  • MRI of the spine revealed an intramedullary tumor extending from level T6 to T12.
  • RESULTS: The tumor was excised completely, using standard microsurgical techniques via a posterior approach.
  • The histological diagnosis was spinal cord HB.
  • CONCLUSION: A review of the literature revealed that this neoplasm is composed of 3 major cell types: endothelial cells, pericytes and stromal cells.
  • Complete microsurgical removal is the treatment of choice for spinal cord HB because the tumor is benign.
  • To the best of our knowledge, sporadic spinal cord HB at this age has not been reported so far.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21389752.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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18. von Boxberg Y, Salim C, Soares S, Baloui H, Alterio J, Ravaille-Veron M, Nothias F: Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis. Eur J Neurosci; 2006 Aug;24(4):1031-41
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  • [Title] Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis.
  • To investigate the molecular basis for the poor regenerative capacity of the mammalian central nervous system (CNS) after injury, we searched for genes whose expression was affected by an adult rat spinal cord hemi-section.
  • Differential screening of a rat spinal cord expression library was performed using polyclonal antibodies raised against lesioned spinal cord tissue.
  • Indeed, very early after spinal cord injury (SCI), high levels of membrane-associated AHNAK are observed on non-neuronal cells invading the lesion site.
  • Our study may thus contribute to the elucidation of the precise molecular and cellular events that eventually render traumatic spinal cord tissue non-permissive for regeneration.
  • [MeSH-major] Membrane Proteins / metabolism. Neoplasm Proteins / metabolism. Neovascularization, Physiologic. Nerve Regeneration. Spinal Cord Injuries

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  • (PMID = 16930430.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Ahnak protein, rat; 0 / Membrane Proteins; 0 / Neoplasm Proteins
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19. Polli FM, Salvati M, Miscusi M, Delfini R, Giangaspero F: Neurocytoma of the spinal cord: report of three cases and review of the literature. Acta Neurochir (Wien); 2009 Jun;151(6):569-74; discussion 574

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurocytoma of the spinal cord: report of three cases and review of the literature.
  • The spinal cord is a very rare location for extra-ventricular neurocytomas.
  • To date, eight cases of neurocytoma of the spinal cord have been described.
  • [MeSH-major] Neurocytoma / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age of Onset. Child. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures. Postoperative Complications / etiology. Radiotherapy. Sex Distribution. Syringomyelia / etiology. Syringomyelia / pathology. Syringomyelia / surgery. Treatment Outcome

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  • (PMID = 19387541.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 23
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20. Bhatti SN, Khan SA, Raja RA, Shah R, Aurangzeb A, Khan AA, Alvi N, Pasha MT: Outcome of intramedullary spinal cord tumours: experience with 18 patients operated at Ayub Teaching Hospital, Abbottabad. J Ayub Med Coll Abbottabad; 2010 Jul-Sep;22(3):15-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of intramedullary spinal cord tumours: experience with 18 patients operated at Ayub Teaching Hospital, Abbottabad.
  • BACKGROUND: Intramedullary spinal cord tumours (IMSCT) are among the uncommon lesions at spinal cord.
  • The Objective was to analyse the surgical outcome of the patients with intramedullary Spinal Tumour operated at Ayub Teaching Hospital (ATH). Abbottabad.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Middle Aged. Neoplasm Grading. Pakistan / epidemiology. Treatment Outcome

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  • (PMID = 22338408.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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21. Choi CY, Adler JR, Gibbs IC, Chang SD, Jackson PS, Minn AY, Lieberson RE, Soltys SG: Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord. Int J Radiat Oncol Biol Phys; 2010 Oct 1;78(2):499-506
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord.
  • PURPOSE: As the spinal cord tolerance often precludes reirradiation with conventional techniques, local recurrence within a previously irradiated field presents a treatment challenge.
  • METHODS AND MATERIALS: We retrospectively reviewed 51 lesions in 42 patients treated from 2002 to 2008 whose spinal metastases recurred in a previous radiation field (median previous spinal cord dose of 40 Gy) and were subsequently treated with stereotactic radiosurgery (SRS).
  • RESULTS: SRS was delivered to a median marginal dose of 20 Gy (range, 10-30 Gy) in 1-5 fractions (median, 2), targeting a median tumor volume of 10.3 cm(3) (range, 0.2-128.6 cm(3)).
  • Converting the SRS regimens with the linear quadratic model (α/β = 3), the median spinal cord maximum single-session equivalent dose (SSED) was 12.1 Gy(3) (range, 4.7-19.3 Gy(3)).
  • CONCLUSION: SRS is safe and effective in the treatment of spinal metastases recurring in previously irradiated fields.
  • Tumor recurrence within 12 months may correlate with biologic aggressiveness and require higher SRS doses (SSED >15 Gy(10)).
  • Further research is needed to define the partial volume retreatment tolerance of the spinal cord and the optimal target dose.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Radiation Tolerance. Radiosurgery / methods. Spinal Cord / radiation effects. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Female. Follow-Up Studies. Humans. Linear Models. Male. Middle Aged. Radiotherapy Dosage. Retreatment. Retrospective Studies. Survival Rate. Tumor Burden. Young Adult

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20133079.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Watanabe M, Sakai D, Yamamoto Y, Iwashina T, Sato M, Mochida J: Upper cervical spinal cord tumors: review of 13 cases. J Orthop Sci; 2009 Mar;14(2):175-81
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  • [Title] Upper cervical spinal cord tumors: review of 13 cases.
  • BACKGROUND: Clinical features of upper cervical spinal cord tumors are not clear because there have been too few published reports.
  • METHODS: We reviewed 13 patients who underwent surgery for an upper cervical spinal cord tumor.
  • Tumor recurrence was seen in three patients for reasons thought to be the same as tumors at other levels, being residual meningiomas lying ventral to the cord and extraforaminal neurinomas.
  • CONCLUSIONS: Spinal cord tumors in the upper cervical region tend to progress as dumbbell tumors.
  • As all the neurinomas had this shape (Eden type 2 or 3) at C1/2, this anatomy might favor progression to the extradural and extraforaminal spaces.However, it also allows total removal of the tumor via a posterior approach.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neurilemmoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Female. Follow-Up Studies. Humans. Laminectomy / methods. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 19337809.001).
  • [ISSN] 1436-2023
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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23. Törnwall J, Snäll J, Mesimäki K: A rare case of spinal cord metastases from oral SCC. Br J Oral Maxillofac Surg; 2008 Oct;46(7):594-5
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  • [Title] A rare case of spinal cord metastases from oral SCC.
  • Intramedullary and intradural spinal cord metastases are rare in general.
  • We present a patient case with an aggressive oral SCC which developed intradural and intramedullary multiple spinal cord metastases.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Spinal Cord Neoplasms / secondary. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Neoplasm Recurrence, Local / pathology. Palliative Care. Skull Base Neoplasms / secondary. Thoracic Vertebrae / pathology

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  • (PMID = 18359540.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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24. Hamamoto Y, Kataoka M, Senba T, Uwatsu K, Sugawara Y, Inoue T, Sakai S, Aono S, Takahashi T, Oda S: Vertebral metastases with high risk of symptomatic malignant spinal cord compression. Jpn J Clin Oncol; 2009 Jul;39(7):431-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vertebral metastases with high risk of symptomatic malignant spinal cord compression.
  • OBJECTIVE: To find vertebral metastases with high risk of symptomatic malignant spinal cord compression (MSCC), features of vertebral metastases caused motor deficits of the lower extremities were examined.
  • Assessed factors were age, sex, primary disease (lung, breast, digestive system and other cancer), lamina involvement, main level of tumor location and vertebral-body involvement.
  • [MeSH-major] Cervical Vertebrae / pathology. Spinal Cord Compression / etiology. Spinal Neoplasms / secondary. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19429929.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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25. Donovan DJ, Freeman JH: Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report. Spine (Phila Pa 1976); 2006 Jun 15;31(14):E460-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report.
  • STUDY DESIGN: We present the case of a patient with a solitary neoplasm of the intramedullary spinal cord.
  • OBJECTIVE: The tumor caused findings of Brown-Séquard syndrome and was the initial presentation of widely metastatic renal cell carcinoma (RCC).
  • SUMMARY OF BACKGROUND DATA: Metastasis of the intramedullary spinal cord has been uncommonly reported and is extremely rare as the initial sign of a disseminated carcinoma.
  • METHODS: The tumor was resected, and the patient's neurologic deficits slowly improved.
  • The histopathology suggested an epithelioid neoplasm.
  • However, despite expert review, the diagnosis was nonspecific, and the tumor appeared benign.
  • RESULTS: It soon recurred in the spinal cord, and repeat imaging studies showed numerous new metastases and a primary renal neoplasm.
  • CONCLUSIONS: Despite being uncommon, spinal cord metastases should be considered in some patients before surgery because it may expedite diagnosis, mitigate the need for surgery, and improve the quality of life for these patients.
  • Clinical factors suggesting metastasis include a personal or family history of malignancy or conditions predisposing to it, the presence of multiple tumors in the spinal cord or elsewhere, nonspecific constitutional symptoms, such as weight loss or decreased appetite, and, specifically for RCC, an abnormally increased hematocrit.
  • [MeSH-major] Brown-Sequard Syndrome / etiology. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16778676.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Rades D, Stalpers LJ, Veninga T, Schulte R, Hoskin PJ, Obralic N, Bajrovic A, Rudat V, Schwarz R, Hulshof MC, Poortmans P, Schild SE: Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression. J Clin Oncol; 2005 May 20;23(15):3366-75
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  • [Title] Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression.
  • PURPOSE: To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC).
  • On multivariate analysis, age, performance status, primary tumor, involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits were significantly associated with functional outcome, whereas the RT schedule was not.
  • [MeSH-major] Radiotherapy, Conformal / methods. Spinal Cord Compression / etiology. Spinal Cord Compression / radiotherapy. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Disease Progression. Dose Fractionation. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Motor Activity. Multivariate Analysis. Neoplasm Staging. Probability. Prognosis. Radiotherapy Dosage. Recovery of Function. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 15908648.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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27. Huey KA, Roy RR, Zhong H, Lullo C: Time-dependent changes in caspase-3 activity and heat shock protein 25 after spinal cord transection in adult rats. Exp Physiol; 2008 Mar;93(3):415-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Time-dependent changes in caspase-3 activity and heat shock protein 25 after spinal cord transection in adult rats.
  • Thus, the purpose of the present study was to determine whether there are any changes in Hsp25, pHsp25 and caspase-3 activity among rat muscles having different fibre type compositions and functions [soleus, adductor longus (AL), plantaris and tibialis anterior (TA)] at 0 (control), 1, 8 or 28 days after a complete spinal cord transection (ST).
  • Thus, the effects of ST on Hsp25 and caspase-3 are muscle specific and time dependent, factors that should be considered in developing any intervention to maintain muscle mass after a spinal cord injury.

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  • (PMID = 18156166.001).
  • [ISSN] 0958-0670
  • [Journal-full-title] Experimental physiology
  • [ISO-abbreviation] Exp. Physiol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR049855-01A1; United States / NIAMS NIH HHS / AR / R03 AR049855-01A1; United States / NINDS NIH HHS / NS / NS 16333; United States / NIAMS NIH HHS / AR / R03 AR 049855; United States / NIAMS NIH HHS / AR / R03 AR049855
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HSP27 Heat-Shock Proteins; 0 / Heat-Shock Proteins; 0 / Hspb1 protein, rat; 0 / Neoplasm Proteins; EC 3.4.22.- / Casp3 protein, rat; EC 3.4.22.- / Caspase 3
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28. Park HS, Jang KY, Kang MJ, Song KJ, Lee KB: Oncocytoma of the spinal cord causing paraplegia - a case report. Spinal Cord; 2007 Feb;45(2):183-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytoma of the spinal cord causing paraplegia - a case report.
  • OBJECTIVES: To describe a rare case of oncocytoma arising from the spinal cord in a 40-year old woman.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Paraplegia / etiology. Spinal Cord Neoplasms / complications
  • [MeSH-minor] Adult. Antigens, Neoplasm. Female. Humans. Immunohistochemistry / methods. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism

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  • (PMID = 16505829.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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29. Lin YH, Huang CI, Wong TT, Chen MH, Shiau CY, Wang LW, Ming-Tak Ho D, Yen SH: Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy. J Neurooncol; 2005 Jan;71(2):205-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy.
  • PURPOSE: To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas.
  • METHODS AND MATERIALS: We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001.
  • All patients received radical surgery for tumor removal with 13 patients achieving complete resection and 7 incomplete resection due to technical difficulty.
  • Among those with incomplete resection, 6 patients received postoperative radiotherapy to tumor bed and only one patient with anaplastic ependymoma received surgery alone.
  • The total tumor dose ranged from 50 to 60 Gy.
  • CONCLUSION: Complete resection alone in spinal cord ependymoma can achieve excellent local control and survival.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / therapy. Nervous System / physiopathology. Retrospective Studies. Salvage Therapy. Survival Analysis. Treatment Outcome

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  • (PMID = 15690140.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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30. Sharma S, Sarkar C, Gaikwad S, Suri A, Sharma MC: Primary neurocytoma of the spinal cord: a case report and review of literature. J Neurooncol; 2005 Aug;74(1):47-52
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  • [Title] Primary neurocytoma of the spinal cord: a case report and review of literature.
  • Most central neurocytomas (CN) and spinal neurocytomas (SN) have a bland well-differentiated histologic picture and uneventful clinical course.
  • Herein we report a case of recurrent spinal neurocytoma in a 24-year-old male who presented with a 2-month history of weakness and numbness of the left upper and lower limbs, and was previously operated at the same site 10 months ago.
  • The tumor showed rare mitoses, focal mild vascular proliferation in both specimens, and necrosis in the initial specimen.
  • However, the presence of histologic atypia and increased MIB1 index in SN appear to more closely correlate with tumor recurrence and a worse overall outcome, in part due to their location in the critical region of cervical spinal cord.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neurocytoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Diagnosis, Differential. Glioma / pathology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male

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  • (PMID = 16078107.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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31. Kiroglu Y, Benek B, Yagci B, Cirak B, Tahta K: Spinal cord compression caused by vertebral hemangioma being symptomatic during pregnancy. Surg Neurol; 2009 Apr;71(4):487-92; discussion 492
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  • [Title] Spinal cord compression caused by vertebral hemangioma being symptomatic during pregnancy.
  • CONCLUSION: According to literature review and our patient's outcome, pregnancy may induce neurologic symptoms and signs in silent spinal hemangiomas.
  • [MeSH-major] Hemangioma / pathology. Pregnancy Complications, Neoplastic / pathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Neoplasms / pathology. Thoracic Vertebrae / pathology
  • [MeSH-minor] Angiography. Back Pain / etiology. Cesarean Section. Embolization, Therapeutic. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / surgery. Paraplegia / etiology. Pregnancy. Reconstructive Surgical Procedures / instrumentation. Reconstructive Surgical Procedures / methods. Reoperation. Spinal Canal / pathology. Spinal Canal / radiography. Treatment Outcome. Vertebroplasty / instrumentation. Vertebroplasty / methods. Young Adult

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  • (PMID = 18295858.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Roser F, Nakamura M, Bellinzona M, Ritz R, Ostertag H, Tatagiba MS: Proliferation potential of spinal meningiomas. Eur Spine J; 2006 Feb;15(2):211-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proliferation potential of spinal meningiomas.
  • OBJECTIVES: The goal of the present study was to quantitatively assess the proliferation index and progesterone receptor status of spinal versus intracranial meningiomas and to determine if these biological indicators can describe the clinical behavior of these tumors.
  • This information could provide the spinal surgeon with important additional information concerning surgical management and follow-up recommendations for the individual patient.
  • METHODS: The study group consisted of 26 patients with spinal and 241 patients with intracranial meningiomas.
  • Proliferation index (Ki-67 Labelling index [LI]) and progesterone-receptor (PR) status of spinal and intracranial meningiomas were compared.
  • Correlations with histological subtype, intratumoral calcifications, tumor vascularity and recurrence-free survival were analyzed.
  • RESULTS: Compared to the spinal group with a mean Ki-67 LI of 2.48% and a positive PR-status of 46%, proliferation rates of intracranial meningiomas were significant higher (Ki-67 LI 3.6%; P-value 0.041).
  • No significant difference in PR status was seen (spinal PR-status 46%, P-value 0.261).
  • Furthermore spinal meningiomas were less vascularized and showed less intratumoral calcifications.
  • Time to recurrence was similar in spinal and intracranial tumors.
  • CONCLUSION: Spinal and intracranial meningiomas differ in their proliferation activity but not in their PR status.
  • However, despite lower proliferation rates, time to recurrence in spinal and cranial meningiomas is comparable in totally excised tumors.
  • Further studies are needed to determine the role of other biological indicators in spinal meningioma growth and response to therapy.
  • [MeSH-major] Meningioma / pathology. Neoplasm Recurrence, Local / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Ki-67 Antigen / metabolism. Male. Middle Aged. Receptors, Progesterone / metabolism

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  • (PMID = 15926055.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC3489402
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33. Perry R, Gonzales I, Finlay J, Zacharoulis S: Primary peripheral primitive neuroectodermal tumors of the spinal cord: report of two cases and review of the literature. J Neurooncol; 2007 Feb;81(3):259-64

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary peripheral primitive neuroectodermal tumors of the spinal cord: report of two cases and review of the literature.
  • The histopathologic diagnosis of this tumor is complex and has led to a variety of treatment approaches.
  • The distinction between central and peripheral type primary spinal cord PNETs has not always been made in the literature, leading to a paucity of data in this disease.
  • [MeSH-major] Neuroectodermal Tumors, Primitive, Peripheral / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / therapy. Neurosurgical Procedures

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  • (PMID = 17203398.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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34. Sandalcioglu IE, Gasser T, Asgari S, Lazorisak A, Engelhorn T, Egelhof T, Stolke D, Wiedemayer H: Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients. Spinal Cord; 2005 Jan;43(1):34-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients.
  • OBJECTIVE: To analyze factors with impact on the functional outcome for patients with surgically treated intramedullary spinal cord tumors (IMSCT) and to point out characteristics of the different histological entities.
  • Functional outcome was analyzed depending on histological features, age, tumor localization and the extension of involved spinal segments.
  • Complete tumor removal was achieved in 65 cases (83.3%) and subtotal resection in nine cases.
  • Although there was no outcome difference with respect to the age and tumor extension, thoracically located IMSCTs proved to harbor an increased risk of postoperative surgical morbidity.
  • [MeSH-major] Astrocytoma / surgery. Dermoid Cyst / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Outcome Assessment (Health Care). Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae / surgery. Child. Child, Preschool. Female. Germany. Humans. Infant. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis / pathology. Postoperative Complications / pathology. Postoperative Complications / physiopathology. Prevalence. Risk Factors. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 15326473.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Clavo B, Robaina F, Montz R, Domper M, Carames MA, Morera J, Pinar B, Hernandez MA, Santullano V, Carreras JL: Modification of glucose metabolism in brain tumors by using cervical spinal cord stimulation. J Neurosurg; 2006 Apr;104(4):537-41
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  • [Title] Modification of glucose metabolism in brain tumors by using cervical spinal cord stimulation.
  • OBJECT: In previous studies the authors have shown potential increases in locoregional blood flow and oxygenation in tumors by using electrical cervical spinal cord stimulation (SCS).
  • In the present report they demonstrate the effect of cervical SCS on brain tumor metabolism, as assessed using [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET).
  • Basal glucose metabolism was higher in the tumor than in the peritumoral areas (p = 0.048).
  • There was a significant increase in glucose uptake during cervical SCS in both the tumor (p = 0.035) and the peritumoral (p = 0.001) areas, with measured increases of 43 and 38%, respectively.
  • [MeSH-major] Blood Glucose / metabolism. Brain Neoplasms / radionuclide imaging. Electric Stimulation Therapy. Glioma / radionuclide imaging. Positron-Emission Tomography. Spinal Cord / physiopathology
  • [MeSH-minor] Adult. Aged. Cerebral Cortex / physiopathology. Cerebral Cortex / radionuclide imaging. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / blood supply. Neoplasm Recurrence, Local / radionuclide imaging. Oxygen Consumption / physiology. Regional Blood Flow / physiology

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  • (PMID = 16619657.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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36. Engelhard HH, Villano JL, Porter KR, Stewart AK, Barua M, Barker FG, Newton HB: Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina. J Neurosurg Spine; 2010 Jul;13(1):67-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina.
  • OBJECT Patients having a primary tumor of the spinal cord, spinal meninges or cauda equina, are relatively rare.
  • Neurosurgeons encounter and treat such patients, and need to be aware of their clinical presentation, tumor types, treatment options, and potential complications.
  • METHODS Extensive information on individuals diagnosed (in the year 2000) as having a primary CNS neoplasm was prospectively collected in a Patient Care Evaluation Study conducted by the Commission on Cancer of the American College of Surgeons.
  • Intraspinal tumor cases were identified based on ICD-O-2 topography codes C70.1, C72.0, and C72.1.
  • RESULTS Patients with primary intraspinal tumors represented 4.5% of the CNS tumor group, and had a mean age of 49.3 years.
  • Pain was the most common presenting symptom, while the most common tumor types were meningioma (24.4%), ependymoma (23.7%), and schwannoma (21.2%).
  • [MeSH-major] Cauda Equina / pathology. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Chi-Square Distribution. Child. Child, Preschool. Ependymoma / epidemiology. Ependymoma / pathology. Ependymoma / surgery. Female. Humans. Infant. Male. Meningioma / epidemiology. Meningioma / pathology. Meningioma / surgery. Middle Aged. Neurilemmoma / epidemiology. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications / epidemiology. Prospective Studies. Radiotherapy, Adjuvant. Registries. Risk Factors. Treatment Outcome. United States / epidemiology

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  • (PMID = 20594020.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Zhong YP, Chen SL, Li X, Hu Y, Zhang JJ, An N: [Multiple myeloma complicated with spinal infiltration]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2010 Apr;18(2):466-8
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  • [Title] [Multiple myeloma complicated with spinal infiltration].
  • This study was aimed to investigate the clinical features of multiple myeloma (MM) complicated by spinal infiltration (extramedullary plasmacytoma) so as to enhance the understanding of this kind of MM and reduce the missed diagnosis for these MM patients.
  • 10 patients with MM complicated by spinal infiltration were enrolled in this study.
  • The involved spinal sites were examined by using magnetic resonance imaging (MRI) or computerized tomography (CT).
  • The results showed that among 10 cases of MM complicated by spinal infiltration, involved pectoral cord was observed in 7 cases, involved lumbar cord in 2 cases and sacral cord in 1 case.
  • In conclusion, the patients with MM complicated by spinal infiltration must be diagnosed and treated as early as possible.

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  • (PMID = 20416190.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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38. Makuria AT, Henderson FC, Rushing EJ, Hartmann DP, Azumi N, Ozdemirli M: Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor. J Neurooncol; 2007 Apr;82(2):199-205
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  • [Title] Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor.
  • We report pathologic findings of an unusual spinal cord tumor from a 33-year-old male patient which showed hybrid features of oligodendroglioma and extraventricular neurocytoma.
  • Histologic examination revealed a clear cell neoplasm containing ganglion-like cells and calcifications, prompting the differential diagnosis of oligodendroglioma and extraventricular neurocytoma.
  • The proliferation index (using antibody MIB1) of the tumor was approximately 30%.
  • [MeSH-major] Neurocytoma / pathology. Oligodendroglioma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 17039400.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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39. Ishibashi H, Morioka T, Katsuta T, Suzuki S, Okada Y: Somatosensory and spinal evoked potentials in patients with upper cervical neurinoma. J Clin Neurophysiol; 2007 Aug;24(4):352-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Somatosensory and spinal evoked potentials in patients with upper cervical neurinoma.
  • Scalp somatosensory evoked potentials (SEPs) and spinal evoked potentials (SpEP) were simultaneously recorded from the exposed surface of the upper cervical cord after median nerve stimulation in five patients undergoing surgery for upper cervical neurinomas.
  • In patients with more advanced tumor, the superficial sensation was abnormal but the deep skin sensation was intact.
  • In these patients, the action potential propagation slowed down but continued partially through the tumor site on the relatively less affected side contralateral to the tumor; however, it stopped at the site of the tumor on the ipsilateral side.
  • It is possible that full functional recovery becomes more difficult during the next stage of tumor development when the propagation of action potentials ceases bilaterally.
  • The intraoperative monitoring of both SEP and SpEP thus appears useful for inferring details of functional integrity and prognosis of the spinal cord near a space-occupying tumor during the critical first two stages of neoplasm in which the spinal function is normal, or a sufficiently large fraction of ascending and descending nerve fibers are functionally suppressed, but are capable of recovery after a surgical intervention.
  • [MeSH-major] Evoked Potentials, Somatosensory / physiology. Neurilemmoma / pathology. Spinal Cord / physiopathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged

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  • (PMID = 17938605.001).
  • [ISSN] 0736-0258
  • [Journal-full-title] Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
  • [ISO-abbreviation] J Clin Neurophysiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Kounin GK, Romansky KV, Traykov LD, Shotekov PM, Stoilova DZ: Primary spinal melanoma with bilateral papilledema. Clin Neurol Neurosurg; 2005 Oct;107(6):525-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal melanoma with bilateral papilledema.
  • Primary leptomeningeal melanoma is an extremely rare spinal tumor.
  • Its clinical presentation with signs of increased intracranial pressure but without cord symptoms is unusual.
  • [MeSH-major] Melanoma / diagnosis. Papilledema / etiology. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cerebrospinal Fluid / cytology. Cervical Vertebrae / pathology. Diagnosis, Differential. Erythrocyte Count. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Spinal Cord / pathology. Spinal Cord Compression / diagnosis. Spinal Cord Compression / surgery. Tomography, X-Ray Computed

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  • (PMID = 16202828.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports
  • [Publication-country] Netherlands
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41. Chen YJ, Hsu HC, Chen KH, Li TC, Lee TS: Transpedicular partial corpectomy without anterior vertebral reconstruction in thoracic spinal metastases. Spine (Phila Pa 1976); 2007 Oct 15;32(22):E623-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transpedicular partial corpectomy without anterior vertebral reconstruction in thoracic spinal metastases.
  • STUDY DESIGN: We retrospectively reviewed surgical results of posterolateral transpedicular partial corpectomy without anterior vertebral reconstruction in 23 consecutive patients with symptomatic metastatic spinal cord compression at thoracic spine.
  • METHODS: From November 2001 to November 2006, 23 patients with symptomatic metastatic spinal cord compression at thoracic spine underwent palliative surgery using a transpedicular partial corpectomy without anterior vertebral reconstruction.
  • The indication for surgery was neurologic progression due to spinal cord compression.
  • [MeSH-major] Neurosurgical Procedures / methods. Spinal Cord Compression / surgery. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Decompression, Surgical / instrumentation. Decompression, Surgical / methods. Decompression, Surgical / mortality. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Palliative Care. Postoperative Complications / etiology. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18090069.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Crabtree KL, Arnold PM: Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously. Pediatr Neurosurg; 2010;46(1):66-70
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  • [Title] Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously.
  • Fifteen months after spinal PA resection, the patient is doing well, has regained the ability to stand independently, and has no evidence of any new or enlarging lesions.
  • To our knowledge, this is the longest time reported from initial tumor resection of leptomeningeal dissemination to the distal spinal cord.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Meningeal Neoplasms / secondary. Neoplasm Seeding. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Child. Follow-Up Studies. Humans. Laminectomy. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Thoracic Vertebrae. Time Factors

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516744.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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43. Yakovlev AE, Ellias Y: Spinal cord stimulation as a treatment option for intractable neuropathic cancer pain. Clin Med Res; 2008 Dec;6(3-4):103-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord stimulation as a treatment option for intractable neuropathic cancer pain.
  • Spinal cord stimulation (SCS) has been used with increased frequency for successful treatment of intractable cancer pain.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma, Squamous Cell / therapy. Colonic Neoplasms / therapy. Electric Stimulation Therapy. Neuralgia / therapy. Spinal Cord. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Palliative Care

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  • (PMID = 19325172.001).
  • [ISSN] 1554-6179
  • [Journal-full-title] Clinical medicine & research
  • [ISO-abbreviation] Clin Med Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2670524
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44. Alkhani A, Blooshi M, Hassounah M: Outcome of surgery for intramedullary spinal ependymoma. Ann Saudi Med; 2008 Mar-Apr;28(2):109-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of surgery for intramedullary spinal ependymoma.
  • BACKGROUND AND OBJECTIVES: Ependymoma is the most frequently encountered intramedullary tumor.
  • This study was designed to define prognostic factors that affect clinical outcome after surgical resection of spinal intramedullary ependymoma.
  • PATIENTS AND METHODS: The medical records, radiological and pathological studies of all patients with intramedullary spinal ependymomas treated surgically in one institution were reviewed retrospectively.
  • Spinal myxopapillary ependymomas were excluded.
  • RESULTS: Surgery was performed on 17 patients (14 males, 3 females, mean age of 42+/-15 years) with spinal ependymoma.
  • The cervical spine was the most common tumor location (71%).
  • Total surgical resection of the tumor was achieved in 11 cases (65%).
  • CONCLUSIONS: Preoperative neurological status was the only statistically significant factor in determining the postoperative neurological outcome of patients with spinal intramedullary ependymomas.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Neoplasm Recurrence, Local / epidemiology. Neurologic Examination. Prognosis. Regression Analysis. Retrospective Studies. Treatment Outcome

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  • (PMID = 18398287.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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45. Tekkök IH, Sav A: Aggressive spinal germinoma with ascending metastases. J Neurooncol; 2005 Nov;75(2):135-41
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  • [Title] Aggressive spinal germinoma with ascending metastases.
  • Initial spinal MR scans showed a sausage-like lesion that extended between L1 and S2.
  • At surgery, an encapsulated intradural extramedullary tumor was removed en bloc.
  • The tumor recurred locally to double its original size only 4 months later.
  • After second surgery, 5,100 cGy of local spinal radiation was given since the pathologist believed that the new tumor exhibited anaplastic features.
  • Subsequently tumor recurred at T6-10 levels and later in the right parasellar region.
  • At 11 months after the initial presentation, a new tumor was diagnosed at T11-T12 levels.
  • Primary spinal germinomas are exceedingly rare.
  • A review of the literature revealed only 14 biopsy-proven spinal germinoma cases.
  • Our case is clearly unique in aggressivity of the tumor, a feature often unexpected for germinomas.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / pathology. Neoplasm Recurrence, Local / diagnosis. Reoperation. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Ependymoma / diagnosis. Follow-Up Studies. Humans. Lumbar Vertebrae / anatomy & histology. Magnetic Resonance Imaging. Male. Sacrum / anatomy & histology. Time Factors. Treatment Outcome

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  • (PMID = 16132516.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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46. Ogawa K, Yoshii Y, Shikama N, Nakamura K, Uno T, Onishi H, Itami J, Shioyama Y, Iraha S, Hyodo A, Toita T, Kakinohana Y, Tamaki W, Ito H, Murayama S: Spinal recurrence from intracranial germinoma: risk factors and treatment outcome for spinal recurrence. Int J Radiat Oncol Biol Phys; 2008 Dec 1;72(5):1347-54
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  • [Title] Spinal recurrence from intracranial germinoma: risk factors and treatment outcome for spinal recurrence.
  • PURPOSE: To analyze retrospectively the risk factors of spinal recurrence in patients with intracranial germinoma and clinical outcomes of patients who developed spinal recurrence.
  • METHODS AND MATERIALS: Between 1980 and 2007, 165 patients with no evidence of spinal metastases at diagnosis were treated with cranial radiotherapy without spinal irradiation.
  • RESULTS: After the initial treatment, 15 patients (9.1%) developed spinal recurrences.
  • Multivariate analysis revealed that large intracranial disease (>/=4 cm) and multifocal intracranial disease were independent risk factors for spinal recurrence.
  • Radiation field, total radiation dose, and the use of chemotherapy did not affect the occurrence of spinal recurrences.
  • Of the 15 patients who experienced spinal recurrence, the 3-year actuarial overall survival and disease-free survival (DFS) rates from the beginning of salvage treatments were 65% and 57%, respectively.
  • The 3-year DFS rate in patients with no intracranial recurrence and treated with both spinal radiotherapy and chemotherapy was 100%, whereas only 17% in patients with intracranial recurrence or treated with radiotherapy alone (p = 0.001).
  • CONCLUSION: Large intracranial disease and multifocal intracranial disease were risk factors for spinal recurrence in patients with intracranial germinoma with no evidence of spinal metastases at diagnosis.
  • For patients who developed spinal recurrence alone, salvage treatment combined with spinal radiotherapy and chemotherapy was effective in controlling the recurrent disease.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / radiotherapy. Germinoma / pathology. Germinoma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Spinal Cord Neoplasms / secondary. Spinal Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Chorionic Gonadotropin / blood. Female. Humans. Japan. Magnetic Resonance Imaging. Male. Radiotherapy Dosage. Recurrence. Retrospective Studies. Risk Factors. Young Adult

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  • (PMID = 18513888.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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47. Biondi A, Ricciardi GK, Faillot T, Capelle L, Van Effenterre R, Chiras J: Hemangioblastomas of the lower spinal region: report of four cases with preoperative embolization and review of the literature. AJNR Am J Neuroradiol; 2005 Apr;26(4):936-45

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  • [Title] Hemangioblastomas of the lower spinal region: report of four cases with preoperative embolization and review of the literature.
  • BACKGROUND AND PURPOSE: Hemangioblastomas (HBs) are rare lesions accounting for 1-5% of all spinal cord tumors.
  • Seventy-five percent of spinal HBs are intramedullary.
  • HBs of the lower spinal region are highly vascular tumors requiring surgery that is potentially complicated by excessive bleeding.
  • In the literature, there are few reports concerning preoperative embolization of HBs, and only few cases are reported in spinal location.
  • Presurgical embolization of HBs located in the lower spinal region has not been described.
  • Although lower spinal HBs are predominantly fed by the anterior spinal artery (ASA), embolization of these lesions is possible and can reduce tumor vascular supply, thus facilitating surgery.
  • We report our experience in four rare cases of solitary HBs occurring in the lower spinal region.
  • METHODS: Clinical charts and radiologic studies of four patients with a preoperatively embolized HB of the lower spinal region were retrospectively reviewed.
  • In the conus medullaris case, the neoplasm was associated with a syrinx.
  • Devascularization of the tumor was performed through the ASA in all cases and also through the posterior spinal artery in one by using non reabsorbable calibrated microspheres in three cases and polyvinyl alcohol particles in the other one.
  • At surgery, the tumor was completely removed in all cases.
  • In addition, manipulation and removal of the tumor was reported to be easy in three of four tumors.
  • No tumor recurred during a follow-up period of 1-6 years (mean, 3.5 years).
  • CONCLUSION: Our results indicate that preoperative embolization of HBs of the lower spinal region is an useful procedure in aiding surgical resection of these highly vascular tumors.
  • [MeSH-major] Chemoembolization, Therapeutic. Hemangioblastoma / therapy. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Preoperative Care. Retrospective Studies

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  • (PMID = 15814949.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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48. Zeng J, Liu H, Song Y: [Total spondylectomy and reconstruction for thoracolumbar spinal tumors with neurological deficit]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 May;21(5):445-8
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  • [Title] [Total spondylectomy and reconstruction for thoracolumbar spinal tumors with neurological deficit].
  • OBJECTIVE: To elucidate the surgical indications and treatment outcome of total spondylectomy and reconstruction for thoracolumbar spinal tumors with neurological deficit.
  • METHODS: From January 1999 to December 2005, 16 patients with thoracolumbar spinal tumors with neurological deficit were treated with total spondylectomy and reconstruction.
  • There were 10 cases of primary tumors of spine (4 giant cell tumor of bone, 3 chondrosarcoma, 2 recurrent aneurysmal bone cyst, and 1 osteosarcoma), and 6 cases of solitary metastasis of thoracic or lumbar spine.
  • Among the 10 patients with primary spinal tumor, nine patients survived with tumor-free, and one with osteosarcoma died because of lung metastases 18 months after surgery.
  • Among the 6 patients with spinal metastasis, three patients survived with tumor-free, and lung metastasis occurred in 1 case 10 months after surgery, two died because of multiple metastases of internal organs 10 months and 32 months after surgery.
  • CONCLUSION: Total spondylectomy and reconstruction is a safe and effective surgery for thoracolumbar spinal tumors with neurological deficit, with pain relief, neurological improvement and minimum tumor recurrence.
  • [MeSH-major] Lumbar Vertebrae / surgery. Reconstructive Surgical Procedures / methods. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Transplantation / methods. Chondrosarcoma / mortality. Chondrosarcoma / pathology. Chondrosarcoma / surgery. Decompression, Surgical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / prevention & control. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Young Adult

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  • (PMID = 17578278.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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49. Salehpour F, Zeinali A, Vahedi P, Halimi M: A rare case of intramedullary cervical spinal cord meningioma and review of the literature. Spinal Cord; 2008 Sep;46(9):648-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of intramedullary cervical spinal cord meningioma and review of the literature.
  • [MeSH-major] Meningioma / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Cervical Vertebrae / anatomy & histology. Diagnosis, Differential. Disease Progression. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures. Paresis / etiology. Paresis / pathology. Paresis / physiopathology. Somatosensory Disorders / etiology. Somatosensory Disorders / pathology. Somatosensory Disorders / physiopathology. Treatment Outcome

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  • (PMID = 18227848.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 5
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50. Biswas A, Puri T, Goyal S, Gupta R, Eesa M, Julka PK, Rath GK: Spinal intradural primary germ cell tumour--review of literature and case report. Acta Neurochir (Wien); 2009 Mar;151(3):277-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal intradural primary germ cell tumour--review of literature and case report.
  • BACKGROUND: Primary spinal cord germ cell tumour is a rare tumour.
  • METHOD: We conducted a PUBMED search using a combination of keywords such as "spinal germ cell tumor," "germinoma," "extradural," "intradural," "intramedullary," "extramedullary," and identified 19 cases of primary spinal germ cell tumour.
  • Magnetic resonance imaging spine showed an inhomogeneous hyperintense soft tissue mass at L(2)-L(4) spinal level.
  • The patient eventually succumbed to his condition, due to compressive transverse myelitis possibly due to cervical cord metastasis.
  • Omission of radiation therapy from the treatment armamentarium might engender local recurrence and spinal dissemination at first failure.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / therapy. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Chorionic Gonadotropin, beta Subunit, Human / analysis. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Decompression, Surgical. Disease Progression. Fatal Outcome. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Myelitis, Transverse / etiology. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / radiotherapy. Neurosurgical Procedures. Radiotherapy. Subarachnoid Space / pathology. Subarachnoid Space / surgery

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  • [CommentIn] Acta Neurochir (Wien). 2009 Aug;151(8):983-4 [19337687.001]
  • (PMID = 19240975.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 41
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51. Setzer M, Vatter H, Marquardt G, Seifert V, Vrionis FD: Management of spinal meningiomas: surgical results and a review of the literature. Neurosurg Focus; 2007;23(4):E14
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  • [Title] Management of spinal meningiomas: surgical results and a review of the literature.
  • OBJECT: In this report, the authors describe their experience in the surgical management of spinal meningiomas at two neurosurgical centers.
  • METHODS: Eighty consecutive patients (22 men and 58 women) with spinal meningiomas who had undergone an operation at two specific neurosurgical centers were included in this study.
  • A review of the literature yielded an additional 651 patients with spinal meningiomas from 9 large studies.
  • The Cox proportional hazards regression analysis showed three significant predictor variables for recurrence: invasion of the arachnoid/pia (p < 0.05; hazard ratio [HR] 1.8, 95% CI 1.2-3.6), Simpson resection grade (p < 0.012, HR 6.8, 95% CI 1.5-3.0), and histological tumor grade (Grade I; p < 0.001, HR 0.001-0.17).
  • CONCLUSIONS: Because of the excellent outcome of surgery for benign spinal meningiomas and the association between duration of symptoms and neurological compromise with a poor functional outcome, early operation is the treatment of choice.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cervical Vertebrae. Cohort Studies. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Recovery of Function. Treatment Outcome

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  • (PMID = 17961038.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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52. Leithner A, Radl R, Gruber G, Hochegger M, Leithner K, Welkerling H, Rehak P, Windhager R: Predictive value of seven preoperative prognostic scoring systems for spinal metastases. Eur Spine J; 2008 Nov;17(11):1488-95

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of seven preoperative prognostic scoring systems for spinal metastases.
  • Predicting prognosis is the key factor in selecting the proper treatment modality for patients with spinal metastases.
  • Eight parameters were assessed for 69 patients (37 male, 32 female): location, general condition, number of extraspinal bone metastases, number of spinal metastases, visceral metastases, primary tumour, severity of spinal cord palsy, and pathological fracture.
  • The data of the present study emphasize that the original Bauer score and a modified Bauer score without scoring for pathologic fracture seem to be practicable and highly predictive preoperative scoring systems for patients with spinal metastases.
  • [MeSH-major] Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology. Preoperative Care / methods. Spinal Neoplasms / diagnosis. Spinal Neoplasms / secondary. Spine / pathology. Spine / surgery
  • [MeSH-minor] Adult. Aged. Decision Support Techniques. Disease Progression. Female. Humans. Life Expectancy. Male. Middle Aged. Neoplasm Staging. Neurosurgical Procedures / standards. Neurosurgical Procedures / statistics & numerical data. Predictive Value of Tests. Prognosis. Prospective Studies. Severity of Illness Index. Survival Analysis. Survival Rate. Treatment Outcome. Viscera / pathology

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  • [Cites] Spine (Phila Pa 1976). 2001 Feb 1;26(3):298-306 [11224867.001]
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  • [CommentIn] Eur Spine J. 2008 Nov;17(11):1496 [18818957.001]
  • (PMID = 18787846.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2583181
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53. Heuer GG, Stiefel MF, Bailey RL, Schuster JM: Acute paraparesis from hemorrhagic spinal ependymoma: diagnostic dilemma and surgical management. Report of two cases and review of the literature. J Neurosurg Spine; 2007 Dec;7(6):652-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute paraparesis from hemorrhagic spinal ependymoma: diagnostic dilemma and surgical management. Report of two cases and review of the literature.
  • Spinal ependymomas are a common type of primary spinal cord neoplasm that frequently occurs in the lumbar spine.
  • Both patients underwent lumbar laminectomies for tumor resection.
  • [MeSH-major] Ependymoma / blood supply. Ependymoma / complications. Hemorrhage / etiology. Neurosurgical Procedures. Paraparesis / diagnosis. Spinal Cord Neoplasms / blood supply. Spinal Cord Neoplasms / complications
  • [MeSH-minor] Acute Disease. Adult. Female. Follow-Up Studies. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Nervous System Diseases / etiology. Treatment Outcome

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  • (PMID = 18074691.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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54. Wahab SH, Simpson JR, Michalski JM, Mansur DB: Long term outcome with post-operative radiation therapy for spinal canal ependymoma. J Neurooncol; 2007 May;83(1):85-9
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  • [Title] Long term outcome with post-operative radiation therapy for spinal canal ependymoma.
  • PURPOSE: A retrospective study was performed to evaluate the long term efficacy and safety of post-operative radiation therapy in the management of spinal canal ependymoma at our institution.
  • METHODS AND MATERIALS: Between 1954 and 1997, 22 patients with spinal canal ependymoma were treated with post-operative radiotherapy at our institution.
  • The median tumor size was 4.0 cm (range 1.5-15.0 cm).
  • There was no significant correlation between tumor size and OS.
  • CONCLUSIONS: Post-operative radiation after subtotal resection is safe and offers durable tumor control and long term patient survival.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Canal. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17206474.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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55. Chen HJ, Xiao JR, Yuan W: Loss of p16INK4, alone and with overexpression of osteopontin, correlates with survival of patients with spinal metastasis from hepatocellular carcinoma. Med Oncol; 2010 Sep;27(3):1005-9
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  • [Title] Loss of p16INK4, alone and with overexpression of osteopontin, correlates with survival of patients with spinal metastasis from hepatocellular carcinoma.
  • Consequently, spinal metastases from HCC are diagnosed more frequently.
  • We investigated the clinical biomarkers of HCC patients presenting with spinal metastasis.
  • Between January 2001 and December 2007, we recruited 30 consecutive HCC patients presenting with spinal metastasis.
  • We found that p16(INK4) and osteopontin might be the biomarkers of patients with spinal metastasis from HCC, a more large-scaled randomized study might be required to confirm the result and study the mechanism.
  • [MeSH-major] Carcinoma, Hepatocellular / secondary. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Gene Expression Regulation, Neoplastic. Liver Neoplasms / pathology. Neoplasm Proteins / analysis. Osteopontin / analysis. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Genes, p16. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Paralysis / etiology. Spinal Cord Compression / etiology. Time Factors

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  • (PMID = 19813107.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; 106441-73-0 / Osteopontin
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56. Hall ND, Fabinyi G, Gul SM, Cher L, Leibsch NJ: Spinal drop metastasis from grade I skull base chondrosarcoma. J Clin Neurosci; 2010 Jan;17(1):135-7
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  • [Title] Spinal drop metastasis from grade I skull base chondrosarcoma.
  • We describe a patient with low-grade chondrosarcoma of the skull base with intradural extramedullary spinal metastases.
  • MRI showed multiple, intradural extramedullary spinal drop metastases.
  • [MeSH-major] Cervical Vertebrae / pathology. Chondrosarcoma / secondary. Neoplasm Metastasis / pathology. Skull Base / pathology. Skull Base Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Cavernous Sinus / pathology. Cavernous Sinus / surgery. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Cranial Fossa, Posterior / pathology. Cranial Fossa, Posterior / surgery. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures / methods. Paresthesia / etiology. Radiculopathy / etiology. Radiotherapy / methods. Sella Turcica / pathology. Sella Turcica / surgery. Sphenoid Bone / pathology. Sphenoid Bone / surgery. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19864142.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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57. Kyriakides AE, Lalam RK, El Masry WS: Acute spontaneous spinal subdural hematoma presenting as paraplegia: a rare case. Spine (Phila Pa 1976); 2007 Oct 1;32(21):E619-22
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  • [Title] Acute spontaneous spinal subdural hematoma presenting as paraplegia: a rare case.
  • OBJECTIVES: To report an unusual case of spontaneous spinal subdural hematoma and to review relevant literature and discuss the etiology, pathogenesis, clinical features, imaging, and prognosis.
  • SUMMARY OF BACKGROUND DATA: Spontaneous spinal subdural hematoma with no underline pathology is a very rare condition.
  • MRI revealed an anterior subdural hematoma from T2-T6 with cord compression.
  • CONCLUSION: Spinal subdural hematoma (SSDH) is uncommon and can be caused by abnormalities of coagulation, blood dyscrasias, or trauma, underlying neoplasm, and arteriovenous malformation.
  • [MeSH-major] Hematoma, Subdural, Spinal / diagnosis. Paraplegia / diagnosis
  • [MeSH-minor] Acute Disease. Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17906565.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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58. Patil CG, Lad SP, Santarelli J, Boakye M: National inpatient complications and outcomes after surgery for spinal metastasis from 1993-2002. Cancer; 2007 Aug 1;110(3):625-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] National inpatient complications and outcomes after surgery for spinal metastasis from 1993-2002.
  • BACKGROUND: Information regarding patient outcomes, complications, and mortality after surgery for spinal metastasis has previously been derived from single-institution series.
  • METHODS: The National Inpatient Sample (NIS) was utilized to identify 26,233 admissions of surgically managed spinal metastasis in the U.S. from 1993 through 2002.
  • CONCLUSIONS: A national perspective is provided on inpatient complications and outcomes after surgery for spinal metastasis in the U.S.
  • [MeSH-major] Postoperative Complications. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bone Neoplasms / mortality. Bone Neoplasms / secondary. Bone Neoplasms / surgery. Brain Neoplasms / mortality. Brain Neoplasms / secondary. Brain Neoplasms / surgery. Child. Child, Preschool. Comorbidity. Female. Hospital Mortality. Humans. Infant. Infant, Newborn. Length of Stay. Male. Middle Aged. Neoplasm Staging. Risk Assessment. Surgery Department, Hospital / statistics & numerical data. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17577227.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Kurokawa R, Kawase T: Spinal arachnoid cyst causing paraplegia following skull base surgery. Neurol Med Chir (Tokyo); 2006 Jun;46(6):309-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal arachnoid cyst causing paraplegia following skull base surgery.
  • The patient underwent subtotal removal of the tumor via an anterior transpetrosal approach.
  • Preexisting long-tract signs and coincidental hydrocephalus confused the neurological findings and delayed detection of the spinal lesion in this case.
  • Neurosurgeons should be alert to the possibilities of insidious spinal lesion if the patient has progressive neurological disorder which does not match the known cranial lesion.
  • [MeSH-major] Arachnoid Cysts / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Postoperative Complications / surgery. Spinal Cord Compression / surgery
  • [MeSH-minor] Adult. Cerebrospinal Fluid Shunts. Decompression, Surgical. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hydrocephalus / diagnosis. Hydrocephalus / surgery. Laminectomy. Magnetic Resonance Imaging. Neoplasm, Residual / diagnosis. Neurologic Examination. Recurrence. Reoperation. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery

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  • (PMID = 16794354.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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60. Gomez DR, Missett BT, Wara WM, Lamborn KR, Prados MD, Chang S, Berger MS, Haas-Kogan DA: High failure rate in spinal ependymomas with long-term follow-up. Neuro Oncol; 2005 Jul;7(3):254-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High failure rate in spinal ependymomas with long-term follow-up.
  • Data on spinal ependymomas are sparse, and prognostic factors remain controversial.
  • Thirty-seven patients with spinal cord ependymomas received postoperative radiation therapy from 1955 to 2001.
  • The influences of radiation dose, extent of resection, Karnofsky performance score, tumor location, and multifocality were assessed in univariate analyses by using the Cox proportional hazards model.
  • Local relapse rates for spinal ependymomas are higher than previously cited, with a large proportion of failures occurring more than five years after diagnosis.

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  • [Cites] Spinal Cord. 1999 Nov;37(11):753-9 [10578245.001]
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  • (PMID = 16053700.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA082103; United States / NCI NIH HHS / CA / U01 CA062399; United States / NCI NIH HHS / CA / CA 82103; United States / NCPDCID CDC HHS / CI / NCI UO1-CA62399
  • [Publication-type] Clinical Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1871913
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61. Gwak HS, Youn SM, Chang U, Lee DH, Cheon GJ, Rhee CH, Kim K, Kim HJ: Usefulness of (18)F-fluorodeoxyglucose PET for radiosurgery planning and response monitoring in patients with recurrent spinal metastasis. Minim Invasive Neurosurg; 2006 Jun;49(3):127-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Usefulness of (18)F-fluorodeoxyglucose PET for radiosurgery planning and response monitoring in patients with recurrent spinal metastasis.
  • INTRODUCTION: With the advancement and successful treatment of metastatic spinal cord disease, newer treatments are needed for the long-term survivors of recurrent disease.
  • The lack of a standardized re-treatment regimen and the difficulty in delineating the tumor margins among patients who have received the treatment with metallic spinal fixation and conventional radiation are two of the challenges to be faced in recurrent metastatic spinal cord disease.
  • In these patients, we applied hypofractionated stereotactic radiosurgery by defining the tumor margin with (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET).
  • PATIENTS AND METHODS: Three consecutive recurrent spinal metastasis patients underwent the CyberKnife treatment (Accuray, Inc., Sunnyvale, CA) from March 2004 to July 2004.
  • The tumor volume on CT-based planning was 2.2 times larger than that of the CT-PET combined planning in case 1 of paraspinal muscle invasion.
  • But the tumor volumes showed minimal changes in the other cases, in which the metastatic tumors were confined to the vertebral bodies.
  • One patient showed marginal failure and the other two patients showed local control of the tumor, as their RI values were 0.65 and 0.87, respectively.
  • CONCLUSION: To our knowledge, this is the first report using FDG-PET with radiosurgery in patients with recurrent spinal metastases hidden under metallic artifacts.
  • [MeSH-major] Cervical Vertebrae. Neoplasm Recurrence, Local / radionuclide imaging. Neoplasm Recurrence, Local / surgery. Radiosurgery. Spinal Neoplasms / radionuclide imaging. Spinal Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Breast Neoplasms / pathology. Female. Fluorodeoxyglucose F18. Humans. Middle Aged. Positron-Emission Tomography. Radiopharmaceuticals. Radiotherapy Planning, Computer-Assisted. Sarcoma / secondary

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  • (PMID = 16921451.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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62. Giebel S, Krawczyk-Kuliś M, Adamczyk-Cioch M, Czyz A, Lech-Marańda E, Piatkowska-Jakubas B, Paluszewska M, Pałynyczko G, Piszcz J, Hołowiecki J, Polish Adult Leukemia Group: Prophylaxis and therapy of central nervous system involvement in adult acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group. Pol Arch Med Wewn; 2008 Jun;118(6):356-61
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  • [Title] Prophylaxis and therapy of central nervous system involvement in adult acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group.
  • The central nervous system (CNS) is one of the most frequent extramedullary locations of adult acute lymphoblastic leukemia (ALL), affecting approximately 5% of patients at diagnosis.
  • The treatment comprises intrathecal cytostatics, cranial and spinal cord irradiation, as well as systemic chemotherapy including agents penetrating to the CNS.
  • Compliance to the prophylactic protocols should be one of the principles in the treatment of adult ALL.
  • [MeSH-major] Central Nervous System Neoplasms / prevention & control. Central Nervous System Neoplasms / therapy. Neoplasm Recurrence, Local. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Quality of Life

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  • (PMID = 18619191.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 28
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63. Sangoi AR, Lim M, Dulai M, Vogel H, Chang S: Suprasellar giant cell ependymoma: a rare neoplasm in a unique location. Hum Pathol; 2008 Sep;39(9):1396-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suprasellar giant cell ependymoma: a rare neoplasm in a unique location.
  • Ependymomas are glial tumors that usually present in the posterior fossa in children and in the spinal cord in adults.
  • We describe the presentation and pertinent radiologic, histologic, immunologic, and ultrastructural findings in conjunction with relevant clinical implications of the first reported case of a suprasellar giant cell ependymoma occurring in a 34-year-old female 7 years after an initial diagnosis of a medullary ependymoma with rare atypical giant cells, a potential tumor seeding culprit.
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 18602668.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Horn EM, Deshmukh VR, Lekovic GP, Dickman CA: Durectomy and reconstruction for the treatment of a recurrent spinal meningioma. Case report. J Neurosurg Spine; 2006 Jul;5(1):76-8
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  • [Title] Durectomy and reconstruction for the treatment of a recurrent spinal meningioma. Case report.
  • The management of spinal meningiomas with extensive involvement of the dura mater is controversial.
  • This case illustrates that thoracic spinal meningiomas with extensive dural involvement can be resected safely with a complete durectomy.
  • [MeSH-major] Dura Mater / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Pregnancy Complications, Neoplastic / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Thoracic Vertebrae

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  • (PMID = 16850962.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Akhaddar A, Ennouali H, Gazzaz M, Naama O, Elmostarchid B, Boucetta M: Idiopathic spinal epidural lipomatosis without obesity: a case with relapsing and remitting course. Spinal Cord; 2008 Mar;46(3):243-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Idiopathic spinal epidural lipomatosis without obesity: a case with relapsing and remitting course.
  • STUDY DESIGN: Case report of a rare form of idiopathic spinal epidural lipomatosis (SEL) manifesting with relapsing and remitting course.
  • Spinal magnetic resonance imaging revealed a fatty epidural mass extending from T4 to T9.
  • RESULTS: Pathological examination of the surgical specimen revealed nodules of mature fat cells without neoplasm.
  • [MeSH-major] Lipomatosis / diagnosis. Lipomatosis / pathology. Spinal Cord Diseases / diagnosis. Spinal Cord Diseases / pathology
  • [MeSH-minor] Adult. Decompression, Surgical. Demyelinating Diseases / diagnosis. Demyelinating Diseases / pathology. Diagnosis, Differential. Epidural Space. Humans. Magnetic Resonance Imaging. Male. Recurrence. Remission, Spontaneous. Thoracic Vertebrae / pathology

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  • (PMID = 17607308.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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66. Zarovnaya EL, Pallatroni HF, Hug EB, Ball PA, Cromwell LD, Pipas JM, Fadul CE, Meyer LP, Park JP, Biegel JA, Perry A, Rhodes CH: Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature. J Neurooncol; 2007 Aug;84(1):49-55
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  • [Title] Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature.
  • There have been only 17 cases of AT/RT in adults reported in the medical literature and the rarity of this tumor makes the diagnosis in adults difficult.
  • We describe a case of an AT/RT of the spinal cord in an adult.
  • An MRI demonstrated a mass lesion in the dorsal spinal cord extending from C4 to C6.
  • The patient underwent three additional surgical procedures for recurrent disease throughout the neuraxis secondary to leptomeningeal spread of the tumor.
  • To our knowledge, this is the first case of a spinal atypical teratoid/rhabdoid tumor in an adult fully documented with molecular, immunohistochemical, cytogenetic and autopsy findings.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. Chromosomes, Human, Pair 22 / genetics. DNA-Binding Proteins / genetics. Neoplasm Recurrence, Local / pathology. Rhabdoid Tumor / pathology. Spinal Cord Neoplasms / pathology. Teratoma / pathology. Transcription Factors / genetics
  • [MeSH-minor] Adult. Cervical Vertebrae. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Monosomy / diagnosis. Monosomy / genetics

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  • (PMID = 17377740.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Number-of-references] 34
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67. Poelen J, Bernsen HJ, Prick MJ: Metastatic medulloblastoma in an adult; treatment with temozolomide. Acta Neurol Belg; 2007 Jun;107(2):51-4
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  • [Title] Metastatic medulloblastoma in an adult; treatment with temozolomide.
  • A medulloblastoma at adult age is extremely rare, and there is no overall accepted treatment, especially not in the case of a relapse.
  • This observation encouraged us to decide to treat an adult patient with a recurrent medulloblastoma with temozolomide.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Cerebellar Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / secondary

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  • (PMID = 17710841.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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68. van der Linden YM, Dijkstra SP, Vonk EJ, Marijnen CA, Leer JW, Dutch Bone Metastasis Study Group: Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer; 2005 Jan 15;103(2):320-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy.
  • BACKGROUND: Adequate prediction of survival is important in deciding on treatment for patients with symptomatic spinal metastases.
  • The authors reviewed 342 patients with painful spinal metastases without neurologic impairment who were treated conservatively within a large, prospectively randomized radiotherapy trial.
  • In 3% of patients, spinal cord compression was reported a mean of 3.5 months after randomization.
  • The median OS was 7 months, and significant predictors for survival were Karnofsky performance score, primary tumor (multivariate analysis; both P < 0.001), and the absence of visceral metastases (multivariate analysis; P = 0.02).
  • CONCLUSIONS: Most patients with spinal metastases have a limited life expectancy and should be treated with caution regarding surgical procedures.
  • [MeSH-major] Cause of Death. Spinal Neoplasms / mortality. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Dose Fractionation. Female. Humans. Male. Middle Aged. Neoplasm Staging. Netherlands. Palliative Care / methods. Predictive Value of Tests. Probability. Prognosis. Proportional Hazards Models. Radiotherapy Dosage. Reference Values. Risk Assessment. Survival Analysis. Treatment Outcome

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  • [Copyright] (c) 2004 American Cancer Society.
  • (PMID = 15593360.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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69. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD: Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine; 2007 Aug;7(2):151-60
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  • [Title] Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure.
  • OBJECT: The authors report data concerning the safety, effectiveness, and patterns of failure obtained in a Phase I/II study of stereotactic body radiotherapy (SBRT) for spinal metastatic tumors.
  • Spinal magnetic resonance imaging was conducted at baseline and at each follow-up visit.
  • RESULTS: The median tumor volume of 74 spinal metastatic lesions was 37.4 cm3 (range 1.6-358 cm3).
  • The actuarial 1-year tumor progression-free incidence was 84% for all tumors.
  • 1) recurrence in the bone adjacent to the site of previous treatment, and 2) recurrence in the epidural space adjacent to the spinal cord.
  • CONCLUSIONS: Analysis of the data obtained in the present study supports the safety and effectiveness of SBRT in cases of spinal metastatic cancer.
  • For patients without a history of radiotherapy, more liberal spinal cord dose constraints than those used in this study could be applied to help reduce failures in the epidural space.
  • [MeSH-major] Radiosurgery. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chest Pain / etiology. Disease Progression. Epidural Space / pathology. Female. Follow-Up Studies. Gastrointestinal Diseases / etiology. Humans. Magnetic Resonance Imaging. Male. Medical Records. Middle Aged. Neoplasm Recurrence, Local. Radiation Injuries. Survival Analysis. Tomography, X-Ray Computed. Treatment Failure. Treatment Outcome

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  • (PMID = 17688054.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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70. Cramer P, Thomale UW, Okuducu AF, Lemke AJ, Stockhammer F, Woiciechowsky C: An atypical spinal meningioma with CSF metastasis: fatal progression despite aggressive treatment. Case report. J Neurosurg Spine; 2005 Aug;3(2):153-8
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  • [Title] An atypical spinal meningioma with CSF metastasis: fatal progression despite aggressive treatment. Case report.
  • The authors report the case of a 23-year-old man who presented with a C1-3 spinal mass.
  • Following intraspinal decompression the tumor was histologically classified as an atypical meningioma (World Health Organization grade II).
  • During the 1.5-year follow-up period the diagnostic examinations identified a local tumor recurrence, an intraspinal C-6 metastasis, and a segmental instability with anterior C2-3 slippage and C3-4 kyphosis.
  • The tumor was resected and occipitocervical stabilization was performed.
  • Despite additional hydroxyurea-based chemotherapy, the patient presented 4 months later with a hemiparesis and a massive recurrence of the tumor mass involving the posterior fossa and the upper thoracic spine.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Cervical Vertebrae. Decompression, Surgical. Disease Progression. Fatal Outcome. Humans. Hydroxyurea / therapeutic use. Joint Instability / etiology. Magnetic Resonance Imaging. Male. Myelography. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neurosurgical Procedures / adverse effects. Radiotherapy, Adjuvant. Reoperation. Spinal Diseases / etiology

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  • (PMID = 16370305.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; X6Q56QN5QC / Hydroxyurea
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71. Selch MT, Lin K, Agazaryan N, Tenn S, Gorgulho A, DeMarco JJ, DeSalles AA: Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors. Surg Neurol; 2009 Dec;72(6):668-74; discussion 674-5
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  • [Title] Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors.
  • A similar approach should be successful for histologically identical spinal nerve sheath tumors.
  • METHODS: The preliminary results of linear accelerator-based spinal radiosurgery were retrospectively reviewed for a group of 25 nerve sheath tumors.
  • Tumor location was cervical 11, lumbar 10, and thoracic 4.
  • Tumor size varied from 0.9 to 4.1 cm (median, 2.1 cm).
  • Tumor size remained stable in 18 cases, and 7 (28%) demonstrated more than 2 mm reduction in tumor size.
  • There has been no clinical or imaging evidence for spinal cord injury.
  • CONCLUSIONS: Results of this limited experience indicate linear accelerator-based spinal radiosurgery is feasible for treatment of benign nerve sheath tumors.
  • Further follow-up is necessary, but our results imply spinal radiosurgery may represent a therapeutic alternative to surgery for nerve sheath tumors.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery. Radiosurgery / instrumentation. Spinal Nerves / surgery. Surgery, Computer-Assisted / instrumentation
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / surgery. Neurologic Examination. Postoperative Complications / diagnosis. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608232.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Kwon YM, Kim KS, Kuh SU, Chin DK, Jin BH, Cho YE: Survival rate and neurological outcome after operation for advanced spinal metastasis (Tomita's classification &gt; or = type 4). Yonsei Med J; 2009 Oct 31;50(5):689-96
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  • [Title] Survival rate and neurological outcome after operation for advanced spinal metastasis (Tomita's classification > or = type 4).
  • PURPOSE: We investigated whether primary malignancy entities and the extent of tumor resection have an effect on the survival rate and neurological improvement in patients with spinal metastases that extend beyond the vertebral compartment (Tomita's classification > or = type 4).
  • MATERIALS AND METHODS: We retrospectively reviewed 87 patients with advanced spinal metastasis who underwent surgery.
  • They were subdivided according to the extent of tumor resection: group 1, gross total resection (G1GT); group 1, subtotal resection (G1ST); group 2, gross total resection (G2GT); and group 2, subtotal resection (G2ST).
  • The origin of the tumor, survival rate, extent of resection, and neurological improvement were analyzed.
  • In group 2, the extent of tumor resection (G2GT vs. G2ST) did not affect survival rate.
  • Four out of 13 patients in the G2GT subgroup showed a local recurrence of spinal tumors and progressive worsening of neurological status.
  • CONCLUSION: In patients with spinal metastases (Tomita's classification > or = type 4), individuals who underwent gross total resection of tumors that responded to adjuvant therapy showed a higher survival rate than those who underwent subtotal resection.
  • [MeSH-major] Spinal Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Combined Modality Therapy. Diagnostic Techniques, Neurological. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 19881974.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2768245
  • [Keywords] NOTNLM ; Bone neoplasm / decision making / metastasis / prognosis
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73. Rades D, Schild SE: Dose-response relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: a review of the literature. J Neurooncol; 2006 May;77(3):311-4
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  • [Title] Dose-response relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: a review of the literature.
  • CTR is less frequent with spinal melanocytomas than with cerebral melanocytomas.
  • This study of 49 spinal melanocytoma patients was performed to define an appropriate radiation dose after ITR.
  • All reported spinal melanocytoma cases were reviewed for extent of surgery, radiotherapy (total dose, dose per fraction), and outcome.
  • The recurrence rates after CTR would mandate the use of post-operative radiotherapy in all spinal meningeal melanocytoma cases.
  • [MeSH-major] Dose Fractionation. Melanoma / radiotherapy. Meningeal Neoplasms / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Cohort Studies. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Survival Analysis

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  • (PMID = 16328723.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 12
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74. Rushing EJ, Smith AB, Smirniotopoulos JG, Douglas AF, Zeng W, Azumi N: Occult leptomeningeal large cell medulloblastoma in an adult. Clin Neuropathol; 2009 May-Jun;28(3):188-92
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  • [Title] Occult leptomeningeal large cell medulloblastoma in an adult.
  • We report the first case of this entity in an adult that proved to be an unsuspected primary leptomeningeal tumor.
  • Cervical spine MRI performed the day prior to admission confirmed the diagnosis of Chiari I malformation and C3-4 disk herniation without spinal cord compression.
  • CONCLUSIONS: Our experience with this unique case illustrates the challenges of diagnosing a primary leptomeningeal neoplasm.
  • [MeSH-minor] Adult. Arnold-Chiari Malformation / complications. Fatal Outcome. Humans. Intervertebral Disc Displacement / complications. Magnetic Resonance Imaging. Male

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  • (PMID = 19537136.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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75. Jost G, Zimmerer S, Frank S, Cordier D, Merlo A: Intradural spinal metastasis of renal cell cancer. Report of a case and review of 26 published cases. Acta Neurochir (Wien); 2009 Jul;151(7):815-21; discussion 821
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  • [Title] Intradural spinal metastasis of renal cell cancer. Report of a case and review of 26 published cases.
  • A literature search for intradural spinal metastases of renal cell carcinoma yielded a total of 26 further cases.
  • 18 patients had sporadic renal cell carcinoma, and 9 patients had von Hippel-Lindau disease (VHL) in which the metastases of the renal cell carcinoma were embedded within spinal haemangioblastomas.
  • Intradural spinal metastases were diagnosed at an earlier age in VHL patients than in sporadic cases (mean 43 +/- 5 years vs. 60 +/- 14.5 years).
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Neoplasm Metastasis / pathology. Spinal Cord / pathology. Spinal Cord Compression / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Back Pain / etiology. Female. Hemangioblastoma / secondary. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Paraparesis / etiology. Secondary Prevention. Subdural Space / pathology. Subdural Space / physiopathology. Subdural Space / surgery. Survival Rate. Urinary Bladder, Neurogenic / etiology. von Hippel-Lindau Disease / complications

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  • (PMID = 19415167.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 46
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76. Gong Y, Wang J, Bai S, Jiang X, Xu F: Conventionally-fractionated image-guided intensity modulated radiotherapy (IG-IMRT): a safe and effective treatment for cancer spinal metastasis. Radiat Oncol; 2008;3:11
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  • [Title] Conventionally-fractionated image-guided intensity modulated radiotherapy (IG-IMRT): a safe and effective treatment for cancer spinal metastasis.
  • BACKGROUND: Treatments for cancer spinal metastasis were always palliative.
  • In the original IMRT plans, the average dose of the planning target volume (PTV) was 61.9 Gy, with the spinal cord dose less than 49 Gy.
  • CONCLUSION: IG-IMRT provides a new approach to treat cancer spinal metastasis.
  • The precise positioning ensures the implementation of optimal IMRT plan, satisfying both the dose escalation of tumor targets and the radiation tolerance of spinal cord.
  • It might benefit the cancer patient with spinal metastasis.
  • [MeSH-major] Dose Fractionation. Radiotherapy / methods. Spinal Neoplasms / radiotherapy. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Safety. Treatment Outcome

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  • (PMID = 18426607.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2373792
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77. Nagamine CM, Jackson CN, Beck KA, Marini RP, Fox JG, Nambiar PR: Acute paraplegia in a young adult long-evans rat resulting from T-cell lymphoma. Contemp Top Lab Anim Sci; 2005 Nov;44(6):53-6
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  • [Title] Acute paraplegia in a young adult long-evans rat resulting from T-cell lymphoma.
  • We describe an unusual case of acute paraplegia in a young adult (7.5-month-old) Long-Evans rat that resulted from a spontaneous T-cell lymphoma.
  • Radiographs did not identify any obvious spinal abnormality or osseous trauma, although the liver and spleen were prominent.
  • Impression smears of the mass revealed a monocytic cell population with cells averaging 7 to 10 microm in diameter and having scant cytoplasm and pleomorphic nuclei, characteristics consistent with a lymphoid neoplasm.
  • Histologically, the neoplasm was unencapsulated, poorly demarcated and highly infiltrative, invading and effacing the bone marrow and epidural space of the vertebral column.
  • Immunophenotyping showed the neoplasm to be of T-cell origin.
  • Although the lymphoma did not invade the meninges of the spinal cord, its impingement on the central and peripheral nervous systems resulted in foci of Wallerian degeneration that contributed to the paraplegia.

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  • (PMID = 16370582.001).
  • [ISSN] 1060-0558
  • [Journal-full-title] Contemporary topics in laboratory animal science
  • [ISO-abbreviation] Contemp Top Lab Anim Sci
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / T32-RR07036
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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78. Andrade FG, de Aguiar PH, Matushita H, Taricco MA, Oba-Shinjo SM, Marie SK, Teixeira MJ: Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo. Arq Neuropsiquiatr; 2009 Sep;67(3A):626-32
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  • [Title] Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo.
  • METHOD: Data of clinical presentation, tumor location, duration of symptoms, degree of resection and complementary treatment of 34 patients with intracranial ependymoma and 31 with intramedullary ependymoma who underwent surgery in the last ten years were collected and correlated with the recurrence time and overall survival.
  • RESULTS: There was statistically significant correlation between the degree of resection and intracranial tumor location, although it is not a hallmark of recurrence.
  • CONCLUSION: The location of the intracranial tumor is connected with the degree of resection; however it is not a predictive factor to overall survival.
  • [MeSH-major] Brain Neoplasms / surgery. Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Disease-Free Survival. Female. Hospitals, University. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult

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  • (PMID = 19722039.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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79. Morgan RJ, Synold T, Mamelak A, Lim D, Al-Kadhimi Z, Twardowski P, Leong L, Chow W, Margolin K, Shibata S, Somlo G, Yen Y, Frankel P, Doroshow JH: Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors. Cancer Chemother Pharmacol; 2010 Oct;66(5):927-33
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  • [Title] Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.

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  • (PMID = 20107803.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA033572; United States / NCI NIH HHS / CA / P30 CA033572-26; United States / NCI NIH HHS / CA / CA 33572
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 094ZI81Y45 / Tamoxifen; 7M7YKX2N15 / Topotecan; BG3F62OND5 / Carboplatin
  • [Other-IDs] NLM/ NIHMS335377; NLM/ PMC3265324
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80. Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutcheon I, Mahajan A, Maor MH, Woo SY: Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol; 2006 Nov;80(2):177-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center.
  • Regardless of the extent of resection, adjuvant RT appears to significantly reduce the rate of tumor progression.
  • [MeSH-major] Ependymoma / drug therapy. Ependymoma / radiotherapy. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neurologic Examination. Prognosis. Retrospective Studies. Salvage Therapy. Survival Analysis. Treatment Failure. Treatment Outcome

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  • [CommentIn] J Neurooncol. 2007 May;82(3):323-5 [17206476.001]
  • (PMID = 16648988.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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81. Idowu MO, Rosenblum MK, Wei XJ, Edgar MA, Soslow RA: Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. Am J Surg Pathol; 2008 May;32(5):710-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein.
  • The adult extra-axial cases demonstrated more architectural variability than the CNS cases.
  • We observed that both the CNS and adult extra-axial ependymomas expressed GFAP diffusely, whereas only 9 stage III, high-grade ovarian serous papillary carcinomas stained with GFAP (2 strongly and diffusely and 7 exhibiting focally weak expression).
  • There were significant immunophenotypic differences between adult extra-axial and CNS ependymomas, with extra-axial cases preferentially expressing 34betaE12 (60% vs. 0%), CK18 (100% vs. 20%), CAM 5.2 (60% vs. 10%), CK7 (80% vs. 10%), ER (100% vs. 10%), and PR (80% vs. 20%).
  • Two spinal cord ependymomas expressed CK18, 1 expressed CK7, and 1 expressed CAM 5.2.
  • The ependymal elements of the sacrococcygeal tumor failed to express 34betaE12, CK18, CAM 5.2, and CK7, like most CNS ependymomas.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Central Nervous System Neoplasms / metabolism. Ependymoma / metabolism. Glial Fibrillary Acidic Protein / metabolism. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Immunoenzyme Techniques. Infant. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging

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  • (PMID = 18360284.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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82. Weber DC, Rutz HP, Bolsi A, Pedroni E, Coray A, Jermann M, Lomax AJ, Hug EB, Goitein G: Spot scanning proton therapy in the curative treatment of adult patients with sarcoma: the Paul Scherrer institute experience. Int J Radiat Oncol Biol Phys; 2007 Nov 1;69(3):865-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spot scanning proton therapy in the curative treatment of adult patients with sarcoma: the Paul Scherrer institute experience.
  • Tumor histology varied with the most common histologic subtypes including liposarcoma and peripheral nerve sheet tumor.
  • All tumors were located in vicinity of critical structures, such as the spinal cord, optic apparatus, bowel, kidney, or bowel.
  • [MeSH-major] Neoplasm Recurrence, Local / radiotherapy. Protons / therapeutic use. Sarcoma / radiotherapy
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Radiotherapy, Adjuvant / adverse effects. Switzerland. Tomography, X-Ray Computed

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  • (PMID = 17606333.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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83. D'Haene N, Coen N, Neugroschl C, Balériaux D, Salmon I: Leptomeningeal dissemination of low-grade intramedullary gliomas: about one case and review. Clin Neurol Neurosurg; 2009 May;111(4):390-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Few cases of LM dissemination of spinal cord low-grade gliomas have been reported in children.
  • Here, we report a case of an intramedullary spinal cord low-grade glioma occurring in an adult presenting by LM dissemination.
  • Lumbar puncture showed low CSF glucose, high CSF protein and no tumor cells.
  • Spinal MRI revealed an intramedullary spinal lesion with a diffuse leptomeningeal enhancement.
  • A spinal meningeal biopsy showed arachnoiditis with isolated atypical cells which were cytokeratin immunopositive.
  • Histological examination revealed a low-grade glial neoplasm composed of monomorphous spindle "piloid" cells with diffuse dissemination to leptomeninges.
  • Spinal low-grade gliomas with LM dissemination may represent a possible distinctive clinico-pathological entity.
  • [MeSH-major] Glioma / secondary. Meningeal Neoplasms / secondary. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 19128871.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 24
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84. Ali Y, Rahme R, Moussa R, Abadjian G, Menassa-Moussa L, Samaha E: Multifocal meningeal melanocytoma: a new pathological entity or the result of leptomeningeal seeding? J Neurosurg; 2009 Sep;111(3):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Meningeal melanocytoma is a rare benign CNS tumor derived from the leptomeningeal melanocytes.
  • Although unusual, malignant transformation with leptomeningeal seeding into the brain or spinal cord may occur years after the initial diagnosis.
  • The authors report a unique case of multifocal benign meningeal melanocytoma involving both cerebellopontine angles and the thoracic spinal cord, with associated diffuse leptomeningeal hyperpigmentation.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle. Melanocytes / pathology. Melanoma / pathology. Meningeal Neoplasms / pathology. Neoplasm Seeding. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19361258.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Benzagmout M, Boujraf S, Oulali N, Chbani L, Amarti A, Chakour K, Chaoui Mel F: Intradural extramedullary ependymoma: is there constantly a hormonal relationship? Surg Neurol; 2008 Nov;70(5):536-8; discussion 538
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ependymoma is a glial tumor that occurs in the central nervous system.
  • The intradural extramedullary location of this neoplasm is very rare.
  • The authors report a case of spinal intradural extramedullary ependymoma in a male and discuss its pathogenesis as well as its clinical, radiological, and therapeutical features.
  • Magnetic resonance imaging revealed an enhanced cervical intradural extramedullary tumor extending from the bulbomedullary junction to the C3 level, with severe spinal cord compression.
  • One year and half later, a local recurrence associated to a small cerebellar lesion was noticed justifying a second spinal intervention.
  • Both surgical interventions demonstrated an intradural extramedullary ependymoma without attachment to the spinal cord or to the dura mater.
  • CONCLUSION: The insufficiency of hormonal theory to explain solely the pathogenesis of this tumor might reveal other potential factors that have not been discussed in earlier literature.
  • [MeSH-major] Ependymoma / diagnosis. Ependymoma / etiology. Gonadal Steroid Hormones / physiology. Neoplasm Recurrence, Local / etiology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Adult. Cervical Vertebrae. Humans. Male. Sex Factors

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  • (PMID = 18207493.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones
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86. Murphy BG, Shivaprasad HL: Ganglioneuroma of the brachial plexus in two cockatiels (Nymphicus hollandicus). Vet Pathol; 2008 Sep;45(5):690-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ganglioneuroma involving the brachial plexus, paraspinal ganglia, and cervical-thoracic spinal cord was diagnosed in 2 adult cockatiels (Nymphicus hollandicus).
  • At necropsy, each bird had a unilateral, firm, gelatinous white to tan multilobular mass at the thoracic inlet expanding and partially obliterating the brachial plexus and cervical spinal cord.
  • Histologically, the masses were characterized by a locally infiltrative neoplasm comprised of spindloid cells forming streams and sheets with interspersed distinct neuron cell bodies consistent with ganglion cells.
  • [MeSH-major] Bird Diseases / pathology. Brachial Plexus / pathology. Cockatoos. Ganglioneuroma / veterinary. Peripheral Nervous System Neoplasms / veterinary. Spinal Cord Neoplasms / veterinary

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  • (PMID = 18725475.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Sheedy SP, Welker KM, DeLone DR, Gilbertson JR: CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol; 2006 Aug;27(7):1483-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This case report presents the clinical and radiographic features of a rare case of biopsy proved brain and spinal cord metastases arising from carcinoma ex PA of the parotid gland.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma, Pleomorphic / pathology. Brain Neoplasms / secondary. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Staging

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  • (PMID = 16908563.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Rodriguez FJ, Crum BA, Krauss WE, Scheithauer BW, Giannini C: Venous congestive myelopathy: a mimic of neoplasia. Mod Pathol; 2005 May;18(5):710-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • By causing diffuse spinal cord enlargement and enhancement on imaging, it may simulate a neoplasm and prompt a biopsy.
  • Preoperative magnetic resonance imaging showed spinal cord enlargement with T2-hyperintensity (86%) and contrast enhancement (57%) at the cervical (14%), thoracolumbar (57%), and/or conus medullaris (57%) level.
  • Prebiopsy spinal angiogram, performed in two patients, was negative.
  • Spinal cord biopsy showed architecturally distorted parenchyma with gliosis and thick hyalinized vessels (100%), variable myelin loss (71%), mild glial atypia (57%), hemosiderin deposition (71%), Rosenthal fibers (43%), vascular thrombosis (29%), and necrosis (29%), features highly suggestive of venous congestive myelopathy.
  • Postbiopsy spinal angiograms were performed in five patients.
  • Histologic changes characteristic of venous congestive myelopathy may be seen in spinal cord biopsies with or without an associated fistula.
  • [MeSH-major] Central Nervous System Vascular Malformations / complications. Spinal Cord Diseases / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Cord / blood supply. Spinal Cord / pathology

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  • (PMID = 15578073.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Costa J, Ruivo J, Miguéns J, Pimentel J: Ganglioglioma of conus medullaris. Acta Neurochir (Wien); 2006 Sep;148(9):977-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Among those uncommon cases in the spinal cord, the conus medullaris is an extremely rare site.
  • As for the supratentorial locations, the extent of surgical resection is the main prognostic factor for gangliogliomas of the spinal cord, and they should be considered in the differential diagnosis of intramedullar neoplasm.
  • [MeSH-major] Ganglioglioma / pathology. Spinal Cord / pathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Decompression, Surgical. Diagnosis, Differential. Disease Progression. Female. Humans. Leg / innervation. Leg / physiopathology. Lumbar Vertebrae / anatomy & histology. Lumbar Vertebrae / surgery. Male. Middle Aged. Muscle Weakness / etiology. Muscle Weakness / physiopathology. Neurosurgical Procedures. Paresis / etiology. Paresis / physiopathology. Prognosis. Sensation Disorders / etiology. Sensation Disorders / physiopathology. Treatment Outcome

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  • (PMID = 16855813.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 16
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90. Santhosh K, Kesavadas C, Radhakrishnan VV, Thomas B, Kapilamoorthy TR, Gupta AK: Rhabdoid and papillary meningioma with leptomeningeal dissemination. J Neuroradiol; 2008 Oct;35(4):236-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although this tumor is known for its aggressive behavior, dissemination into cerebral spinal fluid (CSF) is extremely rare.
  • We report here a case of rhabdoid meningioma in a young man, operated on twice previously, who presented with multiple CSF areas of seeding in the brain and spinal cord.
  • The imaging findings for this tumor, including diffusion and perfusion MR sequences, are highlighted.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Rhabdoid Tumor / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Spinal Cord Neoplasms / secondary

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  • (PMID = 18325590.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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91. Arnold PM, Gust TD, Newell K: Intramedullary leiomyolipoma of the thoracic spine. Case report. J Neurosurg Spine; 2007 May;6(5):438-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The authors report a rare case of spinal intramedullary leiomyolipoma.
  • The histological characteristics and location of the neoplasm are unique, and the presentation, surgical management, and pathological characteristics of the lesion are discussed.
  • [MeSH-major] Leiomyoma / diagnosis. Leiomyoma / surgery. Lipoma / diagnosis. Lipoma / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Thoracic Vertebrae

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  • (PMID = 17542510.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Colnat-Coulbois S, Klein O, Braun M, Thouvenot P, Marchal JC: Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. Neurosurgery; 2010 May;66(5):E1023-4; discussion E1024
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: We report a case of cystic spinal cord pilocytic astrocytoma treated with surgical resection and 2 intracavitary injections of rhenium.
  • Spinal cord magnetic resonance showed a large, cystic, intramedullary tumor extending from T9 to T12.
  • CONCLUSION: Interstitial intracavitary rhenium brachytherapy of recurrent spinal cord cystic astrocytomas achieved excellent stabilization of the cyst with minor side-effects and dramatic improvement of neurological deficits.
  • [MeSH-major] Astrocytoma / radiotherapy. Brachytherapy / methods. Radioisotopes / therapeutic use. Rhenium / therapeutic use. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Cauda Equina / pathology. Combined Modality Therapy. Cysts / pathology. Humans. Male. Neoplasm Recurrence, Local / physiopathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Young Adult

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  • (PMID = 20404673.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radioisotopes; 7440-15-5 / Rhenium
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93. Mangels KJ, Johnson MD, Weil RJ: 35-year-old woman with progressive bilateral leg weakness. Brain Pathol; 2006 Apr;16(2):183-4, 187

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MRI demonstrated a T4-5 intradural mass ventral to the spinal cord, with an enhancing dural tail, consistent with meningioma.
  • At surgery an intradural, extramedullary, firm, black neoplasm was encountered, which invaded the ventral dura and elevated and distorted the spinal cord.
  • Serial sections revealed a homogeneous black tumor without necrosis.
  • H&E stained sections showed an occasionally fascicular tumor of melanocytes and small round blue tumor spindle cells with melanin pigmentation and 1-2 mitotic figures per 10 high-powered fields.
  • A diagnosis of primary meningeal melanocytic tumor was made.
  • IGMS occur in the spinal leptomeninges and intracranially in approximately equal proportions.
  • For primary CNS melanocytic neoplasms, complete tumor resection is preferred, as it leads to cure of well-differentiated and intermediate-grade melanocytomas and most melanomas.
  • [MeSH-major] Meningioma / pathology. Paresis / etiology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Functional Laterality. Humans. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 16768759.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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94. Lekoubou Looti AZ, Kengne AP, Djientcheu Vde P, Kuate CT, Njamnshi AK: Patterns of non-traumatic myelopathies in Yaounde (Cameroon): a hospital based study. J Neurol Neurosurg Psychiatry; 2010 Jul;81(7):768-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aetiologies were dominated by primary and secondary spinal tumours (mainly prostate carcinoma, lymphoma and liver carcinoma) that each accounted for 24.5% of cases.
  • Other causes included spinal tuberculosis (12.9%), tropical spastic paraparesis (five positive for human T cell lymphotrophic virus (HTLV)-I and one for HTLV-II) (4.8%), spinal degenerative disease (4.1%), acute transverse myelitis (4.1%), HIV myelopathy (1.4%), vitamin B12 deficiency myelopathy and multiple sclerosis (0.7%).
  • CONCLUSIONS: Myelopathies in our setting are dominated by spinal compressions.
  • Metastasis is a leading cause of spinal cord compression with liver carcinoma being more frequent than reported elsewhere.
  • Infections nevertheless remain a major cause of spinal cord disease and both cancers and infections constitute public health targets for reducing the incidence of myelopathies.
  • [MeSH-major] Spinal Cord Diseases / pathology
  • [MeSH-minor] Adult. Anal Canal / pathology. Cameroon / epidemiology. Female. Hospitals. Humans. Infection / complications. Infection / epidemiology. Liver Neoplasms / complications. Liver Neoplasms / pathology. Male. Middle Aged. Neoplasm Metastasis. Paraplegia / etiology. Paraplegia / pathology. Quadriplegia / etiology. Quadriplegia / pathology. Sensation. Sex Factors. Spinal Cord Compression / complications. Spinal Cord Compression / pathology

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  • (PMID = 20581141.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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95. Dağli M, Acar A, Eryilmaz A, Göçer C: [Unusual distant metastasis of larynx carcinoma: a case report]. Kulak Burun Bogaz Ihtis Derg; 2007;17(1):37-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor spread may be by a lymphatic or nonlymphatic route.
  • Indirect laryngoscopic examination showed a vegetable mass extending from the left laryngeal side of the epiglottis to the left vocal cord.
  • Magnetic resonance imaging performed due to complaints of back pain and foot numbness demonstrated aggressive spinal cord metastases.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Neoplasm Metastasis

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  • (PMID = 17483610.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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96. Medhkour A, Chan M: Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: a case report and review of the literature. Surg Neurol; 2005 Jun;63(6):576-82; discussion 582-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Spinal glioblastoma multiforme (GBM) is an uncommon entity and metastases are extremely rare.
  • Proper diagnosis via histopathologic and immunochemical staining with close clinical and radiological follow-up is important for the management of this very aggressive tumor.
  • CASE DESCRIPTION: The authors report the clinical features, histopathologic and immunochemical staining characteristics, as well as the radiographic evidence of a case of primary GBM of the conus medullaris with metastases to the whole spinal cord and brain in a 20-year-old man who presented with low back pain and bilateral lower extremity weakness and numbness.
  • Serial magnetic resonance scans, performed after the initial surgery, demonstrated enlargement of the primary GBM in the conus medullaris with metastases to the thoracic and cervical spinal cord as well as to the brain.
  • [MeSH-major] Brain Stem Neoplasms / secondary. Glioblastoma / secondary. Spinal Cord Compression / pathology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Brain Stem / pathology. Brain Stem / physiopathology. Cranial Nerve Diseases / etiology. Cranial Nerve Diseases / pathology. Cranial Nerve Diseases / physiopathology. Disease Progression. Fatal Outcome. Glial Fibrillary Acidic Protein / metabolism. Humans. Low Back Pain / etiology. Low Back Pain / pathology. Low Back Pain / physiopathology. Magnetic Resonance Imaging. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / physiopathology. Paresis / etiology. Paresis / pathology. Paresis / physiopathology. Rare Diseases. Respiratory Insufficiency / etiology. Respiratory Insufficiency / pathology. Respiratory Insufficiency / physiopathology. Spinal Cord / pathology. Spinal Cord / physiopathology

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  • (PMID = 15936395.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
  • [Number-of-references] 13
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97. Kimura H, Nagatomi A, Ochi M, Kurisu K: Intracranial neurenteric cyst with recurrence and extensive craniospinal dissemination. Acta Neurochir (Wien); 2006 Mar;148(3):347-52; discussion 352
MedlinePlus Health Information. consumer health - Neural Tube Defects.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a unique intracranial neurenteric cyst with recurrence and dissemination to the spinal cord.
  • [MeSH-major] Brain Neoplasms / pathology. Neoplasm Metastasis / diagnosis. Neoplasm Recurrence, Local / diagnosis. Neural Tube Defects / diagnosis. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Medulla Oblongata / pathology. Medulla Oblongata / physiopathology. Pons / pathology. Pons / physiopathology. Radiotherapy / methods. Spinal Cord / pathology. Spinal Cord / physiopathology. Subarachnoid Space / pathology. Subarachnoid Space / physiopathology. Treatment Outcome

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  • (PMID = 16421766.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 23
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98. Tsutsumi S, Nonaka Y, Abe Y, Yasumoto Y, Nakazato Y, Ito M: Intramedullary primitive neuroectodermal tumor presenting with rapidly-progressive cauda equina syndrome. Neurol Med Chir (Tokyo); 2010;50(11):1031-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary primitive neuroectodermal tumor presenting with rapidly-progressive cauda equina syndrome.
  • Magnetic resonance (MR) imaging revealed a fusiform intramedullary tumor at T12-L1 levels with heterogeneous enhancement.
  • The patient underwent microsurgical tumor resection.
  • A myelotomy exposed a highly vascular tumor that was subtotally resected.
  • Histological examination demonstrated hypercellular tumor accompanied by significant cell atypism and mitotic figures.
  • Immunohistochemical staining was positive for glial fibrillary acidic protein, S-100 protein, synaptophysin, and INI-1, consistent with primitive neuroectodermal tumor (PNET).
  • PNET should be considered in the differential diagnosis of an intramedullary spinal cord tumor.
  • [MeSH-major] Neuroectodermal Tumors, Primitive, Peripheral / pathology. Polyradiculopathy / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Fatal Outcome. Gait Disorders, Neurologic / etiology. Humans. Magnetic Resonance Imaging / methods. Male. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology

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  • (PMID = 21123993.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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99. Andrychowski J, Taraszewska A, Czernicki Z, Jurkiewicz J, Netczuk T, Dabrowski P: Ten years observation and treatment of multifocal pilocytic astrocytoma. Folia Neuropathol; 2009;47(4):362-70
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Consecutive MRI studies revealed a spinal canal tumours localized at the thoracic level and next at sacral level.
  • The spinal tumour was surgically treated in both locations; the last operation was done 10 years after surgery of the primary temporal lobe tumour.
  • Histopathological examinations of the excised foci from spinal canal revealed neoplasm consistent with WHO grade I pilocytic astrocytoma.

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  • (PMID = 20054789.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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100. James G, Crocker M, King A, Bodi I, Ibrahim A, Chitnavis BP: Malignant triton tumors of the spine. J Neurosurg Spine; 2008 Jun;8(6):567-73
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The authors report on 2 new cases of spinal MTTs, and analyze the 8 previously reported cases found via database search.
  • The patients include a 15-year-old girl with thoracic MTT, and a 24-year-old man with lumbosacral MTT; both patients underwent radical resection with spinal stabilization.
  • Nine patients presented with symptoms related to the spinal cord, cauda equina, or nerve root compression.
  • Seven patients had intradural extension of tumor.
  • Malignant triton tumors are rare but should be included in the differential diagnosis of spinal tumors, particularly in patients who have undergone previous radiotherapy or who have neurofibromatosis.
  • [MeSH-major] Neurilemmoma / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Desmin / analysis. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / analysis. Lumbar Vertebrae / pathology. Male. Neoplasm Recurrence, Local / diagnosis. S100 Proteins / analysis. Sacrum / pathology. Spinal Canal / pathology. Spinal Cord Compression / diagnosis. Thoracic Vertebrae / pathology. Vimentin / analysis

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  • (PMID = 18518679.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Desmin; 0 / Ki-67 Antigen; 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 13
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