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1. Tamura S, Morikawa Y, Senba E: TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience; 2005;130(1):223-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although TRPV2 is expressed in medium- to large-sized dorsal root ganglion (DRG) neurons with myelinated fibers in adult rodents, little is known about the neurotrophin dependence of TRPV2-positive neurons in the developing and adult DRGs of mice.
  • In adult DRGs, TrkC and Ret were expressed in 68% and 25% of TRPV2-positive neurons, respectively.
  • These results suggest that TRPV2 is expressed predominantly in the NT-3-dependent subpopulation of DRG neurons throughout development and in adult mice.
  • [MeSH-major] Calcium Channels / metabolism. Ganglia, Spinal / cytology. Gene Expression Regulation, Developmental / physiology. Motor Neurons / metabolism. Neurotrophin 3 / metabolism
  • [MeSH-minor] Age Factors. Animals. Animals, Newborn. Cell Count / methods. DNA-Binding Proteins / metabolism. Embryo, Mammalian. Female. Immunohistochemistry / methods. Ion Channels / metabolism. Male. Mice. Mice, Inbred C57BL. Neoplasm Proteins / metabolism. Nuclear Proteins / metabolism. Pregnancy. Receptor, trkB / metabolism. Receptor, trkC / metabolism. Skin / embryology. Skin / growth & development. Skin / metabolism. Spinal Cord / embryology. Spinal Cord / growth & development. Spinal Cord / metabolism. TRPM Cation Channels. TRPV Cation Channels

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  • (PMID = 15561438.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels; 0 / DNA-Binding Proteins; 0 / Ion Channels; 0 / Neoplasm Proteins; 0 / Neurotrophin 3; 0 / Nuclear Proteins; 0 / TRPM Cation Channels; 0 / TRPM8 protein, mouse; 0 / TRPV Cation Channels; 0 / Trim27 protein, mouse; 0 / Trpv2 protein, mouse; EC 2.7.10.1 / Receptor, trkB; EC 2.7.10.1 / Receptor, trkC
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2. Aguirre-Quezada DE, Martínez-Anda JJ, Aguilar-Ayala EL, Chávez-Macías L, Olvera-Rabiela JE: [Intracranial and intramedullary peripheral nerve sheath tumours. Case reports from 20 autopsies]. Rev Neurol; 2006 Aug 16-31;43(4):197-200
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  • Histological malignancy of this neoplasm is rare.
  • [MeSH-major] Brain Neoplasms / pathology. Cranial Nerve Neoplasms / pathology. Nerve Sheath Neoplasms / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Autopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neurilemmoma / pathology. Neurofibromatosis 1 / pathology. Neurofibromatosis 2 / pathology. Retrospective Studies

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  • (PMID = 16883507.001).
  • [ISSN] 0210-0010
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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3. Wright JL, Lovelock DM, Bilsky MH, Toner S, Zatcky J, Yamada Y: Clinical outcomes after reirradiation of paraspinal tumors. Am J Clin Oncol; 2006 Oct;29(5):495-502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We evaluated radiation dose to the spinal cord or cauda equina in first and second radiation treatments, time to first recurrence, and clinical outcomes after reirradiation including second recurrence, survival, pain, functional status, and toxicity.
  • Median radiation dose to the planning target volume (PTV) was 2000 cGy; median spinal cord or cauda equina dose was 990 cGy.
  • Median cumulative spinal cord or cauda equina dose was 4198 cGy.
  • [MeSH-major] Neoplasm Recurrence, Local / radiotherapy. Radiotherapy, Intensity-Modulated. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Palliative Care. Radiotherapy Planning, Computer-Assisted. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17023786.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Raco A, Piccirilli M, Landi A, Lenzi J, Delfini R, Cantore G: High-grade intramedullary astrocytomas: 30 years' experience at the Neurosurgery Department of the University of Rome "Sapienza". J Neurosurg Spine; 2010 Feb;12(2):144-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lesions were located in the cervical spinal cord in 12 patients, and in the thoracic cord in 10.
  • [MeSH-major] Astrocytoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Neurosurgical Procedures / mortality. Rome. Spinal Cord / pathology. Spinal Cord / surgery. Thoracic Vertebrae. Time Factors. Treatment Outcome. Young Adult

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  • [CommentIn] J Neurosurg Spine. 2010 Feb;12(2):141-2; discussion 142-3 [20121347.001]
  • (PMID = 20121348.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Zhang J, Hou M, Fei Z, You X, Li J, Luo Y, Liao Z: [Clinical observation about percutaneous vertebroplasty for osteolytic metastatic carcinoma of cervical vertebra]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2009 Feb;23(2):194-7
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  • Among them, 5 patients had primary lung tumor, 1 primary renal tumor, 1 primary breast tumor, 1 primary cervical tumor and 2 unknown primary lesion.
  • All the patients suffered from obviously cervical pain and limitation of activity, including 4 cases of metastatic tumor of the C2 vertebral body, 2 of C3, 2 of C6 and 2 of C7.
  • The general condition of patients was stable before operation, and no blood coagulation dysfunction, radiculalgia and spinal cord compression were detected.
  • Without symptom of spinal cord compression, patients suffered from pain during operation (1 case) and such complications noted by immediate CT or X-rays examination after operation as paravertebral epidural cement leakage (2 cases), transverse foramen cement leakage (1 case) and pinhole reflux (3 cases).
  • During the regular follow-up at 1 week, 3 and 12 months after PVP, all patients had no dislocation of cervical vertebra body, spinal cord compression and paralysis.
  • Five patients died from multiple organ failure due to primary tumor progression, including 3 cases at 6 months after PVP and 2 at 12 months after PVP, and the rest 5 patients' cervical pain were under control, with sound functional recovery.
  • [MeSH-major] Arthroplasty / methods. Cervical Vertebrae. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 19275101.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Rutherford SA, Linton KM, Durnian JM, Cowie RA: Epidural meningioma of the sacral canal. Case report. J Neurosurg Spine; 2006 Jan;4(1):71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spinal meningiomas are reported infrequently as pure epidural tumors, and they are rarely located at the caudal end of the spine.
  • The unique combination of a wholly epidural tumor confined entirely to the sacral canal has not been previously described.
  • Intraoperatively the authors observed an entirely epidural tumor with a small dural attachment at the most caudal end of the thecal sac.
  • Histological examination confirmed that the tumor was an atypical meningioma.
  • A local recurrence developed within 1 year of surgery, and the patient underwent a hemisacrectomy for tumor removal.
  • In addition to the unique nature of this case, the authors also observed a tumor behaving in a far more aggressive fashion than its histological findings would suggest.
  • [MeSH-major] Epidural Space / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / surgery. Prognosis. Sacrococcygeal Region

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  • (PMID = 16506469.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Park HS, Jang KY, Kang MJ, Song KJ, Lee KB: Oncocytoma of the spinal cord causing paraplegia - a case report. Spinal Cord; 2007 Feb;45(2):183-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytoma of the spinal cord causing paraplegia - a case report.
  • OBJECTIVES: To describe a rare case of oncocytoma arising from the spinal cord in a 40-year old woman.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Paraplegia / etiology. Spinal Cord Neoplasms / complications
  • [MeSH-minor] Adult. Antigens, Neoplasm. Female. Humans. Immunohistochemistry / methods. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism

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  • (PMID = 16505829.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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8. Zhong YP, Chen SL, Li X, Hu Y, Zhang JJ, An N: [Multiple myeloma complicated with spinal infiltration]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2010 Apr;18(2):466-8
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  • [Title] [Multiple myeloma complicated with spinal infiltration].
  • This study was aimed to investigate the clinical features of multiple myeloma (MM) complicated by spinal infiltration (extramedullary plasmacytoma) so as to enhance the understanding of this kind of MM and reduce the missed diagnosis for these MM patients.
  • 10 patients with MM complicated by spinal infiltration were enrolled in this study.
  • The involved spinal sites were examined by using magnetic resonance imaging (MRI) or computerized tomography (CT).
  • The results showed that among 10 cases of MM complicated by spinal infiltration, involved pectoral cord was observed in 7 cases, involved lumbar cord in 2 cases and sacral cord in 1 case.
  • In conclusion, the patients with MM complicated by spinal infiltration must be diagnosed and treated as early as possible.

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  • (PMID = 20416190.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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9. Chen HJ, Xiao JR, Yuan W: Loss of p16INK4, alone and with overexpression of osteopontin, correlates with survival of patients with spinal metastasis from hepatocellular carcinoma. Med Oncol; 2010 Sep;27(3):1005-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of p16INK4, alone and with overexpression of osteopontin, correlates with survival of patients with spinal metastasis from hepatocellular carcinoma.
  • Consequently, spinal metastases from HCC are diagnosed more frequently.
  • We investigated the clinical biomarkers of HCC patients presenting with spinal metastasis.
  • Between January 2001 and December 2007, we recruited 30 consecutive HCC patients presenting with spinal metastasis.
  • We found that p16(INK4) and osteopontin might be the biomarkers of patients with spinal metastasis from HCC, a more large-scaled randomized study might be required to confirm the result and study the mechanism.
  • [MeSH-major] Carcinoma, Hepatocellular / secondary. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Gene Expression Regulation, Neoplastic. Liver Neoplasms / pathology. Neoplasm Proteins / analysis. Osteopontin / analysis. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Genes, p16. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Paralysis / etiology. Spinal Cord Compression / etiology. Time Factors

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  • (PMID = 19813107.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; 106441-73-0 / Osteopontin
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10. Gelabert-González M, García-Allut A, Martínez-Rumbo R: [Spinal meningiomas]. Neurocirugia (Astur); 2006 Apr;17(2):125-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal meningiomas].
  • OBJECTIVE: To present the incidence, clinical presentation, radiological features, localization, surgical techniques, and long term results of surgically treated spinal meningiomas.
  • PATIENTS AND METHODS: We review retrospectively 57 spinal meningiomas in 55 patients operated between January 1980 and June 2004.
  • Distribution along the spinal axis was 51 thoracic, 5 cervical and 1 lumbar.
  • CONCLUSIONS: Meningiomas account in our experience, the 46% of spinal cord tumours and account the 7.5% of all meningiomas.
  • Finally we concluded that magnetic resonance imaging is the best imaging technique for diagnosis and total tumour resection improved the surgical results of spinal meningiomas.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 16721479.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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11. Paniago AM, de Oliveira PA, Aguiar ES, Aguiar JI, da Cunha RV, Leme LM, Salgado PR, Domingos JA, Ferraz RL, Chang MR, Bóia MN, Wanke B: Neuroparacoccidioidomycosis: analysis of 13 cases observed in an endemic area in Brazil. Trans R Soc Trop Med Hyg; 2007 Apr;101(4):414-20
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  • Co-morbidity was observed in four patients (malignant neoplasm in three and diabetes mellitus in one).
  • Lesions were seen in the brain hemispheres (nine cases), thalamus (nine cases), cerebellum (four cases), brainstem (four cases) and spinal cord (four cases).
  • These findings emphasize the importance of considering NPCM in the differential diagnosis of brain and spinal cord lesions in endemic areas of paracoccidioidomycosis.
  • [MeSH-minor] Adult. Antifungal Agents / therapeutic use. Follow-Up Studies. Gait Disorders, Neurologic / microbiology. Headache / microbiology. Humans. Male. Middle Aged. Paresis / microbiology

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  • (PMID = 17011605.001).
  • [ISSN] 0035-9203
  • [Journal-full-title] Transactions of the Royal Society of Tropical Medicine and Hygiene
  • [ISO-abbreviation] Trans. R. Soc. Trop. Med. Hyg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents
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12. Longobardi B, De Martin E, Fiorino C, Dell'oca I, Broggi S, Cattaneo GM, Calandrino R: Comparing 3DCRT and inversely optimized IMRT planning for head and neck cancer: equivalence between step-and-shoot and sliding window techniques. Radiother Oncol; 2005 Nov;77(2):148-56
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  • Mean dose, maximum dose and a number of dose-volume parameters regarding CTV1, CTV2, PTV1, PTV2, OARs (spinal and planning spinal cord, parotids, optical structures, brain and temporal mandibular joint) were considered to compare the five modalities (3DCRT, SW, SS5, SS10, SS20); the Conformity Index (CI), the Irradiated Volume (IV) and the Treated Volume (TV) were also considered in the comparison.
  • On the other hand, in some cases SS5 may be slightly sub-effective with respect to SS10-SW when considering PTV coverage and Dmax of the spinal cord.
  • [MeSH-minor] Adult. Aged. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Probability. Radiotherapy Dosage. Radiotherapy, Conformal. Risk Assessment. Sensitivity and Specificity. Survival Analysis. Treatment Outcome

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  • (PMID = 16260056.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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13. Cartenì G, Bordonaro R, Giotta F, Lorusso V, Scalone S, Vinaccia V, Rondena R, Amadori D: Efficacy and safety of zoledronic acid in patients with breast cancer metastatic to bone: a multicenter clinical trial. Oncologist; 2006 Jul-Aug;11(7):841-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Skeletal-related events (SREs) were defined as pathologic bone fractures, spinal cord compression, surgery to bone, radiation therapy to bone, and hypercalcemia of malignancy.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Dose-Response Relationship, Drug. Female. Humans. Infusions, Intravenous. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 16880243.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 0 / Imidazoles; 6XC1PAD3KF / zoledronic acid
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14. van Bueren KL, Bennetts JS, Fowles LF, Berkman JL, Simpson F, Wicking C: Murine embryonic expression of the gene for the UV-responsive protein p15(PAF). Gene Expr Patterns; 2007 Jan;7(1-2):47-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although available data suggest widespread or ubiquitous expression in the adult, here we report highly restricted expression of the p15(PAF) gene in a spatio-temporal manner during mouse embryogenesis.
  • Major sites of expression include the facial prominences, limbs, somites, brain, spinal cord and hair follicles.
  • [MeSH-minor] Animals. Apoptosis / genetics. Apoptosis / radiation effects. Embryonic Development / genetics. Female. Gene Expression Regulation, Developmental. In Situ Hybridization. Male. Mice. Neoplasm Proteins / genetics. Pregnancy. Proliferating Cell Nuclear Antigen / metabolism. Ultraviolet Rays

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  • (PMID = 16815099.001).
  • [ISSN] 1567-133X
  • [Journal-full-title] Gene expression patterns : GEP
  • [ISO-abbreviation] Gene Expr. Patterns
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Neoplasm Proteins; 0 / Proliferating Cell Nuclear Antigen
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15. Qian J, Tian Y, Hu JH, Qiu GX: [Surgical treatment for subaxial cervical spine metastatic tumor]. Zhonghua Yi Xue Za Zhi; 2010 May 4;90(17):1200-3
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  • [Title] [Surgical treatment for subaxial cervical spine metastatic tumor].
  • OBJECTIVE: To explore the surgical treatment method and outcome for subaxial cervical spine metastatic tumor.
  • METHODS: We retrospectively analyzed 7 cases of subaxial cervical spine metastatic tumor treated at our hospital between 2002 and 2007.
  • CONCLUSION: For treating subaxial cervical spine metastatic tumor, anterior vertebrectomy, reconstruction with mesh cage and plate fixation is an effective method to relieve clinical pains and improve neurological functions by complete spinal cord decompression and cervical stability reconstruction.
  • [MeSH-major] Cervical Vertebrae. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Fracture Fixation, Internal. Humans. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies

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  • (PMID = 20646569.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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16. Vural M, Arslantaş A, Ciftçi E, Artan S, Atasoy MA: An unusual case of cervical clear-cell meningioma in pediatric age. Childs Nerv Syst; 2007 Feb;23(2):225-9
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  • Cervical magnetic resonance imaging revealed an intradural-extramedullary tumor at the level of C1-C2.
  • The tumor was resected totally.
  • This report is the first ICCM case at upper cervical region (C1-C2) in both adult and pediatric age populations.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Pediatrics. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Nucleic Acid Hybridization / methods. Retrospective Studies. Review Literature as Topic

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  • [Cites] Am J Surg Pathol. 1995 May;19(5):493-505 [7726360.001]
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  • (PMID = 17021731.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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17. Albayrak BS, Gorgulu A, Kose T: A case of intra-dural malignant peripheral nerve sheath tumor in thoracic spine associated with neurofibromatosis type 1. J Neurooncol; 2006 Jun;78(2):187-90
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  • [Title] A case of intra-dural malignant peripheral nerve sheath tumor in thoracic spine associated with neurofibromatosis type 1.
  • Histopathological diagnosis was malignant peripheral nerve sheath tumor (MPNST), a rare sarcoma with a dismal prognosis.
  • Tumor recurred in its previous site with an adjacent apical mass in the left lung 7 weeks following initial surgery and repeat surgery was performed with complete removal of intra-dural tumor.
  • It must always be considered the possibility of a rare but a devastating tumor, MPNST beside schwannomas and neurofibromas in patients with NF1 when an intra-spinal mass is diagnosed.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurofibromatosis 1 / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Dura Mater / pathology. Humans. Male. Neoplasm Recurrence, Local / surgery. Thoracic Vertebrae. Treatment Outcome


18. Choi CY, Adler JR, Gibbs IC, Chang SD, Jackson PS, Minn AY, Lieberson RE, Soltys SG: Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord. Int J Radiat Oncol Biol Phys; 2010 Oct 1;78(2):499-506
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  • [Title] Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord.
  • PURPOSE: As the spinal cord tolerance often precludes reirradiation with conventional techniques, local recurrence within a previously irradiated field presents a treatment challenge.
  • METHODS AND MATERIALS: We retrospectively reviewed 51 lesions in 42 patients treated from 2002 to 2008 whose spinal metastases recurred in a previous radiation field (median previous spinal cord dose of 40 Gy) and were subsequently treated with stereotactic radiosurgery (SRS).
  • RESULTS: SRS was delivered to a median marginal dose of 20 Gy (range, 10-30 Gy) in 1-5 fractions (median, 2), targeting a median tumor volume of 10.3 cm(3) (range, 0.2-128.6 cm(3)).
  • Converting the SRS regimens with the linear quadratic model (α/β = 3), the median spinal cord maximum single-session equivalent dose (SSED) was 12.1 Gy(3) (range, 4.7-19.3 Gy(3)).
  • CONCLUSION: SRS is safe and effective in the treatment of spinal metastases recurring in previously irradiated fields.
  • Tumor recurrence within 12 months may correlate with biologic aggressiveness and require higher SRS doses (SSED >15 Gy(10)).
  • Further research is needed to define the partial volume retreatment tolerance of the spinal cord and the optimal target dose.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Radiation Tolerance. Radiosurgery / methods. Spinal Cord / radiation effects. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Female. Follow-Up Studies. Humans. Linear Models. Male. Middle Aged. Radiotherapy Dosage. Retreatment. Retrospective Studies. Survival Rate. Tumor Burden. Young Adult

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20133079.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Draper H, Chitayat D, Ein SH, Langer JC: Long-term functional results following resection of neonatal sacrococcygeal teratoma. Pediatr Surg Int; 2009 Mar;25(3):243-6
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  • PURPOSE: Sacrococcygeal teratoma (SCT) is the most common congenital neoplasm in neonates.
  • Median age of respondents was 16.7 years (3-29), and none of the respondents had a recurrent tumor.
  • The remaining patient had all three problems, but his SCT had involved the spinal cord.
  • [MeSH-major] Spinal Neoplasms / surgery. Teratoma / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Humans. Prognosis. Recovery of Function. Retrospective Studies. Sacrococcygeal Region. Surveys and Questionnaires. Treatment Outcome. Young Adult

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  • (PMID = 19189110.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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20. Kwon YM, Kim KS, Kuh SU, Chin DK, Jin BH, Cho YE: Survival rate and neurological outcome after operation for advanced spinal metastasis (Tomita's classification > or = type 4). Yonsei Med J; 2009 Oct 31;50(5):689-96
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  • [Title] Survival rate and neurological outcome after operation for advanced spinal metastasis (Tomita's classification > or = type 4).
  • PURPOSE: We investigated whether primary malignancy entities and the extent of tumor resection have an effect on the survival rate and neurological improvement in patients with spinal metastases that extend beyond the vertebral compartment (Tomita's classification > or = type 4).
  • MATERIALS AND METHODS: We retrospectively reviewed 87 patients with advanced spinal metastasis who underwent surgery.
  • They were subdivided according to the extent of tumor resection: group 1, gross total resection (G1GT); group 1, subtotal resection (G1ST); group 2, gross total resection (G2GT); and group 2, subtotal resection (G2ST).
  • The origin of the tumor, survival rate, extent of resection, and neurological improvement were analyzed.
  • In group 2, the extent of tumor resection (G2GT vs. G2ST) did not affect survival rate.
  • Four out of 13 patients in the G2GT subgroup showed a local recurrence of spinal tumors and progressive worsening of neurological status.
  • CONCLUSION: In patients with spinal metastases (Tomita's classification > or = type 4), individuals who underwent gross total resection of tumors that responded to adjuvant therapy showed a higher survival rate than those who underwent subtotal resection.
  • [MeSH-major] Spinal Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Combined Modality Therapy. Diagnostic Techniques, Neurological. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 19881974.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2768245
  • [Keywords] NOTNLM ; Bone neoplasm / decision making / metastasis / prognosis
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21. Chen ZY, Ma YB, Sheng XG, Zhang XL, Xue L, Song QQ, Liu NF, Miao HQ: [Intensity modulated radiation therapy for patients with gynecological malignancies after hysterectomy and chemotherapy/radiotherapy]. Zhonghua Zhong Liu Za Zhi; 2007 Apr;29(4):305-8
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  • However, The mean dose irradiated to small intestine, bladder, rectum, kidney and spinal cord was 21.3 Gy, 37.8 Gy, 35.3 Gy, 8.5 Gy, 22.1 Gy, respectively.
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Diarrhea / etiology. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy Dosage. Survival Analysis

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  • (PMID = 17760262.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. Paul B, Dhir R, Landsittel D, Hitchens MR, Getzenberg RH: Detection of prostate cancer with a blood-based assay for early prostate cancer antigen. Cancer Res; 2005 May 15;65(10):4097-100
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  • Using an EPCA-based ELISA, the protein was measured in the plasma of 46 individuals, including prostate cancer patients, healthy individuals, other cancer patients, spinal cord injury victims, and patients with prostatitis.
  • Statistical analysis showed a significant difference in EPCA levels between the prostate cancer population and each of the other groups, specifically the healthy donors (P < 0.0001), bladder cancer patients (P = 0.03), and spinal cord injury patients (P = 0.001).
  • [MeSH-major] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Prostatic Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Antibodies, Neoplasm / blood. Antibodies, Neoplasm / immunology. Enzyme-Linked Immunosorbent Assay. Humans. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 15899799.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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23. Horn EM, Deshmukh VR, Lekovic GP, Dickman CA: Durectomy and reconstruction for the treatment of a recurrent spinal meningioma. Case report. J Neurosurg Spine; 2006 Jul;5(1):76-8
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  • [Title] Durectomy and reconstruction for the treatment of a recurrent spinal meningioma. Case report.
  • The management of spinal meningiomas with extensive involvement of the dura mater is controversial.
  • This case illustrates that thoracic spinal meningiomas with extensive dural involvement can be resected safely with a complete durectomy.
  • [MeSH-major] Dura Mater / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Pregnancy Complications, Neoplastic / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Thoracic Vertebrae


24. Amdur RJ, Bennett J, Olivier K, Wallace A, Morris CG, Liu C, Mendenhall WM: A prospective, phase II study demonstrating the potential value and limitation of radiosurgery for spine metastases. Am J Clin Oncol; 2009 Oct;32(5):515-20
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  • METHODS: Twenty-five patients were treated on a prospective phase II protocol of single-fraction stereotactic body radiotherapy or radiosurgery for tumors near the spinal cord (N = 21).
  • Patients received 15 Gy, given a spinal cord limit of 12 Gy to 0.1 mL for patients with no prior spine radiotherapy (N = 9), and 5 Gy to 0.5 mL for patients with prior spine radiotherapy (N = 12).
  • [MeSH-major] Radiosurgery / methods. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Feasibility Studies. Follow-Up Studies. Humans. Neoplasm Metastasis. Pain / etiology. Prospective Studies. Radiotherapy Dosage. Survival Rate. Treatment Outcome

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  • (PMID = 19528790.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
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25. Rodriguez FJ, Crum BA, Krauss WE, Scheithauer BW, Giannini C: Venous congestive myelopathy: a mimic of neoplasia. Mod Pathol; 2005 May;18(5):710-8
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  • By causing diffuse spinal cord enlargement and enhancement on imaging, it may simulate a neoplasm and prompt a biopsy.
  • Preoperative magnetic resonance imaging showed spinal cord enlargement with T2-hyperintensity (86%) and contrast enhancement (57%) at the cervical (14%), thoracolumbar (57%), and/or conus medullaris (57%) level.
  • Prebiopsy spinal angiogram, performed in two patients, was negative.
  • Spinal cord biopsy showed architecturally distorted parenchyma with gliosis and thick hyalinized vessels (100%), variable myelin loss (71%), mild glial atypia (57%), hemosiderin deposition (71%), Rosenthal fibers (43%), vascular thrombosis (29%), and necrosis (29%), features highly suggestive of venous congestive myelopathy.
  • Postbiopsy spinal angiograms were performed in five patients.
  • Histologic changes characteristic of venous congestive myelopathy may be seen in spinal cord biopsies with or without an associated fistula.
  • [MeSH-major] Central Nervous System Vascular Malformations / complications. Spinal Cord Diseases / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Cord / blood supply. Spinal Cord / pathology

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  • (PMID = 15578073.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Rochet N, Jensen AD, Sterzing F, Munter MW, Eichbaum MH, Schneeweiss A, Sohn C, Debus J, Harms W: Adjuvant whole abdominal intensity modulated radiotherapy (IMRT) for high risk stage FIGO III patients with ovarian cancer (OVAR-IMRT-01) - Pilot trial of a phase I/II study: study protocol. BMC Cancer; 2007 Dec 19;7:227
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  • For treatment planning bone marrow, kidneys, liver, spinal cord, vertebral bodies and pelvic bones are defined as organs at risk.
  • [MeSH-minor] Adult. Aged. Clinical Protocols. Dose Fractionation. Endpoint Determination. Feasibility Studies. Female. Humans. Middle Aged. Neoplasm Staging. Organ Specificity. Patient Selection. Pilot Projects. Radiation Injuries / prevention & control. Research Design. Risk

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  • (PMID = 18093313.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2212657
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27. Tobias ME, McGirt MJ, Chaichana KL, Goldstein IM, Kothbauer KF, Epstein F, Jallo GI: Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst; 2008 Feb;24(2):219-23
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  • [Title] Surgical management of long intramedullary spinal cord tumors.
  • OBJECT: Spinal cord tumors represent approximately 10-20% of primary central nervous system tumors.
  • MATERIALS AND METHODS: We retrospectively reviewed all patients undergoing surgical resection of longitudinally extensive intramedullary spinal cord tumors involving the majority of the spinal cord between 1990 and 2002.
  • One (8%) patient died from progression of anaplastic oligodendroglioma, and two (15%) underwent reoperation for recurrent tumor (ganglioglioma, grade II astrocytoma).
  • Five (38%) patients required fusion for progressive spinal deformity.
  • CONCLUSION: Gross total resection of holocord and longitudinally extensive intramedullary spinal cord tumors can be achieved with preservation of long-term neurological function in many cases.
  • Serial imaging is recommended to guide subsequent resection for tumor recurrence and stabilization of progressive spinal deformity.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cervical Vertebrae. Child. Child, Preschool. Female. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 17639420.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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28. Scorsetti M, Navarria P, Mancosu P, Alongi F, Castiglioni S, Cavina R, Cozzi L, Fogliata A, Pentimalli S, Tozzi A, Santoro A: Large volume unresectable locally advanced non-small cell lung cancer: acute toxicity and initial outcome results with rapid arc. Radiat Oncol; 2010;5:94
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  • In particular: for GTV D1% = 105.6 ± 1.7%, D99% = 96.7 ± 1.8%, D5%-D95% = 6.3 ± 1.4%; contra-lateral lung mean dose resulted in 13.7 ± 3.9Gy, for spinal cord D1% = 39.5 ± 4.0Gy, for heart V45Gy = 9.0 ± 7.0Gy, for esophagus D1% = 67.4 ± 2.2Gy.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Organs at Risk / radiation effects

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  • (PMID = 20950469.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2972299
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29. Gomez DR, Missett BT, Wara WM, Lamborn KR, Prados MD, Chang S, Berger MS, Haas-Kogan DA: High failure rate in spinal ependymomas with long-term follow-up. Neuro Oncol; 2005 Jul;7(3):254-9
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  • [Title] High failure rate in spinal ependymomas with long-term follow-up.
  • Data on spinal ependymomas are sparse, and prognostic factors remain controversial.
  • Thirty-seven patients with spinal cord ependymomas received postoperative radiation therapy from 1955 to 2001.
  • The influences of radiation dose, extent of resection, Karnofsky performance score, tumor location, and multifocality were assessed in univariate analyses by using the Cox proportional hazards model.
  • Local relapse rates for spinal ependymomas are higher than previously cited, with a large proportion of failures occurring more than five years after diagnosis.

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  • (PMID = 16053700.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA082103; United States / NCI NIH HHS / CA / U01 CA062399; United States / NCI NIH HHS / CA / CA 82103; United States / NCPDCID CDC HHS / CI / NCI UO1-CA62399
  • [Publication-type] Clinical Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1871913
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30. von Boxberg Y, Salim C, Soares S, Baloui H, Alterio J, Ravaille-Veron M, Nothias F: Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis. Eur J Neurosci; 2006 Aug;24(4):1031-41
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  • [Title] Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis.
  • To investigate the molecular basis for the poor regenerative capacity of the mammalian central nervous system (CNS) after injury, we searched for genes whose expression was affected by an adult rat spinal cord hemi-section.
  • Differential screening of a rat spinal cord expression library was performed using polyclonal antibodies raised against lesioned spinal cord tissue.
  • Indeed, very early after spinal cord injury (SCI), high levels of membrane-associated AHNAK are observed on non-neuronal cells invading the lesion site.
  • Our study may thus contribute to the elucidation of the precise molecular and cellular events that eventually render traumatic spinal cord tissue non-permissive for regeneration.
  • [MeSH-major] Membrane Proteins / metabolism. Neoplasm Proteins / metabolism. Neovascularization, Physiologic. Nerve Regeneration. Spinal Cord Injuries

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  • (PMID = 16930430.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Ahnak protein, rat; 0 / Membrane Proteins; 0 / Neoplasm Proteins
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31. Ma YT, Ramachandra P, Spooner D: Case report: primary subcutaneous sacrococcygeal ependymoma: a case report and review of the literature. Br J Radiol; 2006 May;79(941):445-7
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  • [MeSH-major] Ependymoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers / analysis. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Ilium. Immunohistochemistry / methods. Lymphatic Metastasis. Magnetic Resonance Imaging. Radiotherapy, Adjuvant. Reoperation. S100 Proteins / analysis. Sacrococcygeal Region. Vimentin / analysis

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  • (PMID = 16632628.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 12
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32. Alkhani A, Blooshi M, Hassounah M: Outcome of surgery for intramedullary spinal ependymoma. Ann Saudi Med; 2008 Mar-Apr;28(2):109-13
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  • [Title] Outcome of surgery for intramedullary spinal ependymoma.
  • BACKGROUND AND OBJECTIVES: Ependymoma is the most frequently encountered intramedullary tumor.
  • This study was designed to define prognostic factors that affect clinical outcome after surgical resection of spinal intramedullary ependymoma.
  • PATIENTS AND METHODS: The medical records, radiological and pathological studies of all patients with intramedullary spinal ependymomas treated surgically in one institution were reviewed retrospectively.
  • Spinal myxopapillary ependymomas were excluded.
  • RESULTS: Surgery was performed on 17 patients (14 males, 3 females, mean age of 42+/-15 years) with spinal ependymoma.
  • The cervical spine was the most common tumor location (71%).
  • Total surgical resection of the tumor was achieved in 11 cases (65%).
  • CONCLUSIONS: Preoperative neurological status was the only statistically significant factor in determining the postoperative neurological outcome of patients with spinal intramedullary ependymomas.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Neoplasm Recurrence, Local / epidemiology. Neurologic Examination. Prognosis. Regression Analysis. Retrospective Studies. Treatment Outcome

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  • (PMID = 18398287.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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33. Zhang WD, Xie CM, Mo YX, Li JY: [CT and MRI features of peripheral primitive neuroectodermal tumor]. Ai Zheng; 2007 Jun;26(6):643-6
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  • [Title] [CT and MRI features of peripheral primitive neuroectodermal tumor].
  • BACKGROUND & OBJECTIVE: It's difficult to distinguish peripheral primitive neuroectodermal tumor (PNET) from other small round cell tumors such as Ewing's sarcoma by histological examination.
  • RESULTS: The tumors were located in the left ala nasi, right lower jaw bone, left chest wall, right chest wall, left spermatic cord, paraspinal, and lumbar vertebral canal.
  • The tumors in the paraspinal and vertebral canal showed well-defined soft tissue masses without involving cord and cauda equine on MRI, and showed isointensity or hypointensity on T1WI and isointensity or hyperintensity on T2WI.
  • [MeSH-major] Jaw Neoplasms / radiography. Neuroectodermal Tumors, Primitive, Peripheral / diagnosis. Neuroectodermal Tumors, Primitive, Peripheral / radiography. Spinal Neoplasms / diagnosis. Thoracic Neoplasms / radiography
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Genital Neoplasms, Male / radiography. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Retrospective Studies. Spermatic Cord / radiography. Spinal Canal. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 17562273.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Mawrin C, Schneider T, Firsching R, Wiedemann FR, Dietzmann K, Bornemann A, Romeike BF, Sellhaus B, von Deimling A: Assessment of tumor cell invasion factors in gliomatosis cerebri. J Neurooncol; 2005 Jun;73(2):109-15
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  • [Title] Assessment of tumor cell invasion factors in gliomatosis cerebri.
  • Gliomatosis cerebri (GC) is a rare brain tumor characterized by widespread infiltration of large parts of the brain and sometimes even the spinal cord.
  • To determine the cause of this extraordinary degree of brain invasion, we studied immunoexpression of factors associated with brain infiltration in low-grade and high-grade tumor samples from nine GC cases.
  • We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele.
  • Immunohistochemical analyses showed that tumor samples from three GC cases expressed Tenascin-C, whereas six cases had CD44 - immunopositive tumor samples.
  • In tumor-free control DNA, the Arg(388) phenotype was present in 60%.
  • These data indicate that CD44 expression might be related to the tumor infiltration in GC, and that patients suffering from GC or other common astrocytomas do not have a significantly increased frequency of the tumor cell motility-favoring Arg(388) FGFR4 allele.
  • [MeSH-minor] Adolescent. Adult. Aged. Alleles. Arginine / genetics. Female. Humans. Immunohistochemistry. Male. Matrix Metalloproteinase 9 / metabolism. Middle Aged. Neoplasm Invasiveness. Receptor, Fibroblast Growth Factor, Type 4. Severity of Illness Index. Tenascin / metabolism

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  • (PMID = 15981099.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Receptors, Fibroblast Growth Factor; 0 / Tenascin; 94ZLA3W45F / Arginine; EC 2.7.10.1 / FGFR4 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 4; EC 3.4.24.35 / Matrix Metalloproteinase 9
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35. Kawahara N, Tomita K, Murakami H, Demura S, Yoshioka K, Miyazaki T: Total excision of a recurrent chondrosarcoma of the thoracic spine: a case report of a seven-year-old boy with fifteen years follow-up. Spine (Phila Pa 1976); 2010 May 15;35(11):E481-7
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  • OBJECTIVE: To describe the surgical procedure for removal of the recurrent tumor.
  • RESULTS.: A 7-year-old boy had difficulty with ambulation because of a tumor recurrence 18 months after posterior curettage of the primary chondrosarcoma of the T6 and T7.
  • The spinal cord was severely compressed by the epidural mass, which was located anterior and to the left side of the spinal canal.
  • The epidural tumor including the tumor capsule on the left side of the dural tube was excised piecemeal fashion.
  • En bloc corpectomy of T6 and T7 including the capsulated epidural tumor that was located ventrally to the spinal cord was performed.
  • His spinal alignment was maintained.
  • CONCLUSION: Total excision (en bloc corpectomy with partially piecemeal removal) including the tumor margin has given local control and survival for 15 years in this patient who had recurrent chondrosarcoma.
  • Anteroposterior biologic spinal reconstruction has maintained spinal alignment.
  • [MeSH-major] Chondrosarcoma / surgery. Neoplasm Recurrence, Local / surgery. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adolescent. Child. Humans. Male. Treatment Outcome. Young Adult

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  • (PMID = 20421855.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Zhou J, Li NY, Zhou XJ, Zhou HB, Wu B, Jiang SJ, Ma HH, Zhang RS: [Clinicopathologic study of von Hippel-Lindau syndrome-related and sporadic hemangioblastomas of central nervous system]. Zhonghua Bing Li Xue Za Zhi; 2010 Mar;39(3):145-50
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  • There were 10 patients presenting other lesions related to VHL, including 6 retinal HBs, 4 pancreatic tumors (endocrine tumor and microcystic cystadenoma), 1 clear renal cell carcinoma, 4 renal cysts and 1 endolymphatic sac tumor.
  • Tumor cells of HB stained positive for vimentin, EGFR, Inhibin alpha and D2-40, but negative for CD34 and CD68.
  • The most common tumor is CNS-HB, which occurs predominantly in the cerebellum.
  • Patients with VHL syndrome tend to present at a younger age than patients with sporadic CNS-HBs, and VHL related HB occurs more predominantly in the brain stem and spinal cord.
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Child. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / metabolism. Humans. Inhibins / metabolism. Ki-67 Antigen / metabolism. Male. Middle Aged. Neoplasm Recurrence, Local. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Receptor, Epidermal Growth Factor / metabolism. Retinal Neoplasms / metabolism. Retinal Neoplasms / pathology. Retinal Neoplasms / surgery. Survival Analysis. Vimentin / metabolism. Young Adult

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  • (PMID = 20450758.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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37. Gatcombe H, Lawson J, Phuphanich S, Crocker I: Treatment related myelitis in Hodgkin's lymphoma following stem cell transplant, chemotherapy and radiation: a case report and review of the literature. J Neurooncol; 2006 Sep;79(3):293-8
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  • We report here a case of a 25-year-old Middle Eastern man with progressive myelopathy 21 months following low dose irradiation of the cord in the context of high dose chemotherapy and stem cell rescue and a review of the literature.
  • [MeSH-major] Hodgkin Disease / therapy. Myelitis / etiology. Radiation Injuries. Radiotherapy / adverse effects. Spinal Cord / radiation effects
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / therapy. Stem Cell Transplantation. Tomography, X-Ray Computed

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  • (PMID = 16617406.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Hanse MC, Franssen JH, Sleeboom HP, Hoffmann CF, Taal W: Two exceptional phenomena in an anaplastic oligo-astrocytoma. J Neurooncol; 2006 Jun;78(2):197
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Neoplasm Recurrence, Local / complications. Sagittal Sinus Thrombosis / etiology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Cervical Vertebrae. Female. Functional Laterality. Humans

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  • (PMID = 16575535.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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39. Brinar M, Rados M, Habek M, Poser CM: Enlargement of the spinal cord: inflammation or neoplasm? Clin Neurol Neurosurg; 2006 Mar;108(3):284-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Enlargement of the spinal cord: inflammation or neoplasm?
  • Intramedullary spinal tumours are uncommon lesions that can cause significant difficulties in the differential diagnosis between inflammatory diseases such as multiple sclerosis and acute disseminated encephalomyelitis, and vascular malformations or neoplasms.
  • We report five cases in which the history and the clinical symptoms suggested an inflammatory process of the spinal cord but the MRI characteristics were those of neoplastic lesions.
  • [MeSH-major] Astrocytoma / diagnosis. Encephalomyelitis, Acute Disseminated / diagnosis. Multiple Sclerosis / diagnosis. Myelitis / etiology. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [CommentIn] Clin Neurol Neurosurg. 2007 Dec;109(10):931-3 [17868981.001]
  • [CommentIn] Clin Neurol Neurosurg. 2006 Dec;108(8):811-2 [16793201.001]
  • (PMID = 16376015.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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40. Patel YJ, Payne Smith MD, de Belleroche J, Latchman DS: Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells. Brain Res Mol Brain Res; 2005 Apr 4;134(2):256-74
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  • Amyotrophic lateral sclerosis (ALS) is an adult-onset degenerative disorder characterised by the death of motor neurons in the cortex, brainstem, and spinal cord; resulting in progressive muscle weakness, atrophy, and death from respiratory paralysis, usually within 3-5 years of symptom onset.
  • [MeSH-major] Amyotrophic Lateral Sclerosis / prevention & control. Ganglia, Spinal / cytology. HSP70 Heat-Shock Proteins / administration & dosage. Heat-Shock Proteins / administration & dosage. Neoplasm Proteins / administration & dosage. Neurons / drug effects

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  • (PMID = 15836922.001).
  • [ISSN] 0169-328X
  • [Journal-full-title] Brain research. Molecular brain research
  • [ISO-abbreviation] Brain Res. Mol. Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acid Chloromethyl Ketones; 0 / Culture Media, Serum-Free; 0 / Drug Combinations; 0 / Enzyme Inhibitors; 0 / HSP27 Heat-Shock Proteins; 0 / HSP70 Heat-Shock Proteins; 0 / Heat-Shock Proteins; 0 / Hspb1 protein, rat; 0 / Neoplasm Proteins; 0 / Neuroprotective Agents; 0 / benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; 147336-22-9 / Green Fluorescent Proteins; EC 1.15.1.- / superoxide dismutase 1; EC 1.15.1.1 / Superoxide Dismutase; H88EPA0A3N / Staurosporine
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41. Selch MT, Lin K, Agazaryan N, Tenn S, Gorgulho A, DeMarco JJ, DeSalles AA: Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors. Surg Neurol; 2009 Dec;72(6):668-74; discussion 674-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Initial clinical experience with image-guided linear accelerator-based spinal radiosurgery for treatment of benign nerve sheath tumors.
  • A similar approach should be successful for histologically identical spinal nerve sheath tumors.
  • METHODS: The preliminary results of linear accelerator-based spinal radiosurgery were retrospectively reviewed for a group of 25 nerve sheath tumors.
  • Tumor location was cervical 11, lumbar 10, and thoracic 4.
  • Tumor size varied from 0.9 to 4.1 cm (median, 2.1 cm).
  • Tumor size remained stable in 18 cases, and 7 (28%) demonstrated more than 2 mm reduction in tumor size.
  • There has been no clinical or imaging evidence for spinal cord injury.
  • CONCLUSIONS: Results of this limited experience indicate linear accelerator-based spinal radiosurgery is feasible for treatment of benign nerve sheath tumors.
  • Further follow-up is necessary, but our results imply spinal radiosurgery may represent a therapeutic alternative to surgery for nerve sheath tumors.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery. Radiosurgery / instrumentation. Spinal Nerves / surgery. Surgery, Computer-Assisted / instrumentation
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / surgery. Neurologic Examination. Postoperative Complications / diagnosis. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608232.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Li FM, Luo W, He ZC, Zhang L, Sun Y, Qin WJ, Lu LX, Han F, Liu XQ, Liu MZ: [Dosimetric analysis of radiotherapy with middle shielding blocks of different widths at the lower cervical supraclavicular field for stage N2-3 nasopharyngeal carcinoma]. Ai Zheng; 2007 Oct;26(10):1127-32
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  • There was no significant difference in high dose coverage (V95 and V90) of PTV for the primary gross tumor region (PTVnx), PTV for the cervical metastatic nodes (PTVnd), PTV for the high risk region around primary gross tumor (PTVnx60), PTV for the high risk region around metastatic nodes (PTVnd60), and subclinical lesion region above cricoid cartilage (PTV50b) among the 4 plans.
  • There was no difference in the doses for the spinal cord and larynx among the 4 plans.
  • There were no difference in the doses for the spinal cord and larynx among the 4 plans.
  • [MeSH-minor] Adult. Esophagus / radiation effects. Female. Humans. Lead. Lymph Nodes / radiation effects. Male. Middle Aged. Neck. Neoplasm Staging. Radiotherapy Dosage. Thyroid Gland / radiation effects. Tomography, X-Ray Computed. Trachea / radiation effects

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  • (PMID = 17927886.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 2P299V784P / Lead
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43. Habermann CR, Gossrau P, Graessner J, Arndt C, Cramer MC, Reitmeier F, Jaehne M, Adam G: Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors? Rofo; 2005 Jul;177(7):940-5
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  • MATERIAL AND METHODS: Fifty consecutive patients with a suspected primary tumor of the parotid gland were examined with a DW EPI sequence (TR 1,500 msec, TE 77 msec, field of view 250 x 250 mm, pixel size 2.10 x 1.95 mm, section thickness 5 mm).
  • Apparent diffusion coefficient (ADC) maps were digitally transferred to MRIcro (Chris Rorden, University of Nottingham, Great Britain) and evaluated with a manually placed irregular region of interest (ROI) containing the entire tumor.
  • Additionally, the contralateral, non affected parotid gland was measured and a circular ROI containing 100 - 200 pixels was placed in the cerebrospinal fluid (CSF) next to the spinal cord in every patient.
  • RESULTS: In 45 patients, a primary neoplasm of the parotid gland could be histologically verified.
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Feasibility Studies. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • [ErratumIn] Rofo. 2005 Sep;177(9):1312
  • (PMID = 15973595.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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44. Junming M, Cheng Y, Dong C, Jianru X, Xinghai Y, Quan H, Wei Z, Mesong Y, Dapeng F, Wen Y, Bin N, Lianshun J, Huimin L: Giant cell tumor of the cervical spine: a series of 22 cases and outcomes. Spine (Phila Pa 1976); 2008 Feb 1;33(3):280-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the cervical spine: a series of 22 cases and outcomes.
  • STUDY DESIGN: A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003.
  • Though surgical resection of GCT arising in the cervical spine is commonly regarded as a recommended treatment method, it is still a challenge to achieve satisfactory results, especially for the late or recurrent cases, and there are few large series of cases reported with long-term follow-up of this tumor that are found in special segments in the literature.
  • RESULTS: One patient with C1-C2 GCT (vertebral body and posterior element involvement) who received subtotal resection of the tumor showed aggravation of neurologic deficit and died shortly after the surgery.
  • The symptom of radicular pain almost disappeared, and patients suffering from spinal cord compression recovered well with at least 1 or 2 levels based on Frankel grading system when re-evaluated at 3 months after operation.
  • As a kind of benign but local aggressive or low potential malignancy tumor, we should take an aggressive attitude to excise the tumor as much as possible while reserving the neural function as a precondition.
  • [MeSH-major] Bone Neoplasms / surgery. Cervical Vertebrae / surgery. Giant Cell Tumor of Bone / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Diskectomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Staging. Postoperative Complications. Spinal Fusion. Survival Rate. Treatment Outcome


45. Ketter R, Rahnenführer J, Henn W, Kim YJ, Feiden W, Steudel WI, Zang KD, Urbschat S: Correspondence of tumor localization with tumor recurrence and cytogenetic progression in meningiomas. Neurosurgery; 2008 Jan;62(1):61-9; discussion 69-70
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  • [Title] Correspondence of tumor localization with tumor recurrence and cytogenetic progression in meningiomas.
  • OBJECTIVE: Meningiomas are mostly benign tumors that originate from the coverings of the brain and spinal cord.
  • METHODS: Statistical analyses were performed for the karyotypes of 661 meningiomas with respect to localization, progression, and recurrence of the tumor.
  • A mathematical mixture model estimates typical pathogenetic routes in terms of the accumulation of somatic chromosome changes in tumor cells.
  • The model generates a genetic progression score (GPS) that estimates the prognosis as related to the cytogenetic properties of a given tumor.
  • This corresponds to a total rate of recurrence of 8.0% after macroscopically complete tumor extirpation.
  • Higher GPS values were shown to be strongly correlated with tumor recurrence (P = 2.9 x 10(-7)).
  • [MeSH-minor] Adult. Aged. Cytogenetics. Disease Progression. Female. Follow-Up Studies. Humans. Karyotyping. Male. Middle Aged. Models, Theoretical. Neoplasm Recurrence, Local. Proportional Hazards Models. Retrospective Studies

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  • [CommentIn] Neurosurgery. 2009 Jun;64(6):E1206; author reply E1206 [19487876.001]
  • (PMID = 18300892.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD: Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine; 2007 Aug;7(2):151-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure.
  • OBJECT: The authors report data concerning the safety, effectiveness, and patterns of failure obtained in a Phase I/II study of stereotactic body radiotherapy (SBRT) for spinal metastatic tumors.
  • Spinal magnetic resonance imaging was conducted at baseline and at each follow-up visit.
  • RESULTS: The median tumor volume of 74 spinal metastatic lesions was 37.4 cm3 (range 1.6-358 cm3).
  • The actuarial 1-year tumor progression-free incidence was 84% for all tumors.
  • 1) recurrence in the bone adjacent to the site of previous treatment, and 2) recurrence in the epidural space adjacent to the spinal cord.
  • CONCLUSIONS: Analysis of the data obtained in the present study supports the safety and effectiveness of SBRT in cases of spinal metastatic cancer.
  • For patients without a history of radiotherapy, more liberal spinal cord dose constraints than those used in this study could be applied to help reduce failures in the epidural space.
  • [MeSH-major] Radiosurgery. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chest Pain / etiology. Disease Progression. Epidural Space / pathology. Female. Follow-Up Studies. Gastrointestinal Diseases / etiology. Humans. Magnetic Resonance Imaging. Male. Medical Records. Middle Aged. Neoplasm Recurrence, Local. Radiation Injuries. Survival Analysis. Tomography, X-Ray Computed. Treatment Failure. Treatment Outcome

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  • (PMID = 17688054.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Sciubba DM, Burdette EC, Cheng JJ, Pennant WA, Noggle JC, Petteys RJ, Alix C, Diederich CJ, Fichtinger G, Gokaslan ZL, Murphy KP: Percutaneous computed tomography fluoroscopy-guided conformal ultrasonic ablation of vertebral tumors in a rabbit tumor model. Laboratory investigation. J Neurosurg Spine; 2010 Dec;13(6):773-9
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  • [Title] Percutaneous computed tomography fluoroscopy-guided conformal ultrasonic ablation of vertebral tumors in a rabbit tumor model. Laboratory investigation.
  • The major challenge of using RFA for spinal tumors is difficulty protecting the spinal cord and nerves from damage.
  • However, conforming ultrasound energy to match the exact anatomy of the tumor may provide successful ablation in such sensitive locations.
  • In a rabbit model of vertebral body tumor, the authors have successfully ablated tumors using an acoustic ablator placed percutaneously via computed tomography fluoroscopic (CTF) guidance.
  • METHODS: Using CTF guidance, 12 adult male New Zealand White rabbits were injected with VX2 carcinoma cells in the lowest lumbar vertebral body.
  • Three multisensor thermocouple arrays were placed around the lesion to provide measurement of tissue temperature during ablation, at thermal doses ranging from 100 to 1,000,000 TEM (thermal equivalent minutes at 43°C), and tumor volumes were given a tumoricidal dose of acoustic energy.
  • Pathological specimens were obtained to determine the extent of tumor death and surrounding tissue damage.
  • Measured temperature distributions were used to reconstruct volumetric doses of energy delivered to tumor tissue, and such data were correlated with pathological findings.
  • RESULTS: All rabbits were successfully implanted with VX2 cells, leading to a grossly apparent spinal and paraspinal tissue mass.
  • Significant tumor death was noted in all specimens without collateral damage to nearby nerve tissue.
  • Tissue destruction just beyond the margin of the tumor was noted in some but not all specimens.
  • CONCLUSIONS: Using a rabbit intravertebral tumor model, the authors have successfully delivered tumoricidal doses of acoustic energy via a therapeutic ultrasound ablation probe placed percutaneously with CTF guidance.
  • The authors have thus established the first technical and preclinical feasibility study of controlled ultrasound ablation of spinal tumors in vivo.

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  • (PMID = 21121752.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA112852-03; United States / NCI NIH HHS / CA / R44 CA112852; United States / NCI NIH HHS / CA / R44 CA112852-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Fadul CE, Kominsky AL, Meyer LP, Kingman LS, Kinlaw WB, Rhodes CH, Eskey CJ, Simmons NE: Long-term response of pituitary carcinoma to temozolomide. Report of two cases. J Neurosurg; 2006 Oct;105(4):621-6
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  • Pituitary carcinoma is a rare tumor characterized by poor responsiveness to therapy, leading to early death.
  • The second patient was a 26-year-old man with hyperprolactinemia from a prolactin-secreting pituitary tumor.
  • Spine magnetic resonance images obtained to search for causes of neck pain showed a vertebral tumor, which was later confirmed through pathological analysis to be a metastatic pituitary carcinoma.
  • [MeSH-major] Adenoma / drug therapy. Luteinizing Hormone / secretion. Neoplasm Recurrence, Local / drug therapy. Pituitary Neoplasms / drug therapy. Prolactinoma / drug therapy
  • [MeSH-minor] Adult. Drug Administration Schedule. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Radiosurgery. Retreatment. Spinal Cord / pathology. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / secondary. Treatment Failure

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  • (PMID = 17044568.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-67-9 / Luteinizing Hormone
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49. Glotsos D, Georgiadis P, Kostopoulos S, Daskalakis A, Kalatzis I, Ravazoula P, Cavouras D: A pilot study investigating the minimum requirements necessary for grading astrocytomas remotely. Anal Quant Cytol Histol; 2009 Oct;31(5):262-8
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  • Next, the grade of each tumor was assessed based on the set of 5 images and the World Health Organization (WHO) description of 8 histologic characteristics defined as crucial in grading astrocytomas.

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  • (PMID = 20701092.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Ohba S, Akiyama T, Kanai R, Onozuka S, Kawase T: Endodermal cyst of the cranio-cervical junction. Acta Neurochir (Wien); 2008 Mar;150(3):257-63; discussion 263
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  • [MeSH-major] Central Nervous System Cysts / pathology. Neurosurgical Procedures / methods. Skull Base Neoplasms / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Axis, Cervical Vertebra / pathology. Axis, Cervical Vertebra / surgery. Cervical Atlas / pathology. Cervical Atlas / surgery. Child, Preschool. Cranial Fossa, Posterior / pathology. Cranial Fossa, Posterior / surgery. Decompression, Surgical / methods. Endoderm / pathology. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Occipital Bone / pathology. Occipital Bone / surgery. Spinal Canal / pathology. Spinal Canal / surgery. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Treatment Outcome

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  • (PMID = 18213442.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 41
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51. Andrychowski J, Taraszewska A, Czernicki Z, Jurkiewicz J, Netczuk T, Dabrowski P: Ten years observation and treatment of multifocal pilocytic astrocytoma. Folia Neuropathol; 2009;47(4):362-70
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  • Consecutive MRI studies revealed a spinal canal tumours localized at the thoracic level and next at sacral level.
  • The spinal tumour was surgically treated in both locations; the last operation was done 10 years after surgery of the primary temporal lobe tumour.
  • Histopathological examinations of the excised foci from spinal canal revealed neoplasm consistent with WHO grade I pilocytic astrocytoma.

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  • (PMID = 20054789.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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52. Furák J, Troján I, Szöke T, Agócs L, Csekeö A, Kas J, Svastics E, Eller J, Tiszlavicz L: Lung cancer and its operable brain metastasis: survival rate and staging problems. Ann Thorac Surg; 2005 Jan;79(1):241-7; discussion 241-7
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  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Neoplasm Staging / methods
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Combined Modality Therapy. Cranial Irradiation. Craniotomy. Disease-Free Survival. Female. Humans. Hungary / epidemiology. Life Tables. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Pneumonectomy. Radiotherapy, Adjuvant. Reoperation. Spinal Cord Neoplasms / secondary. Spinal Cord Neoplasms / surgery. Survival Analysis. Survival Rate


53. Koenig MA, Geocadin RG, Kulesza P, Olivi A, Brem H: Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report. J Neurosurg; 2005 Feb;102(2):371-5
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  • Despite aggressive measures, including tumor resection, ventriculoperitoneal shunt placement, and the initiation of conventional radiation therapy, the ensuing leptomeningeal carcinomatosis proved to be rapidly fatal.
  • [MeSH-minor] Adult. Combined Modality Therapy. Cranial Irradiation. Fatal Outcome. Female. Humans. Ki-67 Antigen / analysis. Neoplasm Invasiveness. Neoplasm, Residual / pathology. Neoplasm, Residual / radiotherapy. Neoplasm, Residual / surgery. Radiotherapy, Adjuvant. Reoperation. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / secondary

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  • (PMID = 15739568.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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54. Crabtree KL, Arnold PM: Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously. Pediatr Neurosurg; 2010;46(1):66-70
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  • [Title] Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously.
  • Fifteen months after spinal PA resection, the patient is doing well, has regained the ability to stand independently, and has no evidence of any new or enlarging lesions.
  • To our knowledge, this is the longest time reported from initial tumor resection of leptomeningeal dissemination to the distal spinal cord.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Meningeal Neoplasms / secondary. Neoplasm Seeding. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Child. Follow-Up Studies. Humans. Laminectomy. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Thoracic Vertebrae. Time Factors

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516744.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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55. Chiewvit P, Danchaivijitr N, Sirivitmaitrie K, Chiewvit S, Thephamongkhol K: Does magnetic resonance imaging give value-added than bone scintigraphy in the detection of vertebral metastasis? J Med Assoc Thai; 2009 Jun;92(6):818-29
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  • The MR imaging findings were studied: location (cervical or thoracic or lumbar or sacrum spine), number of lesions (solitary or multiple lesions), pattern of enhancement (homogeneous or inhomogeneous), involvement of spinal canal, compression of spinal cord, extradural extension, other incidental findings such as pulmonary metastasis, pleural effusion, lymphadenopathy The final diagnosis was confirmed clinically and followed-up for further management (radiation or surgery) or followed-up by MR imaging (1 month-16 months) and bone scintigraphy (5 months-12 months).
  • MR imaging demonstrated metastatic cord compression in 16 cases.
  • Extradural extension causes spinal canal narrowing in 30 cases.
  • [MeSH-major] Lumbar Vertebrae / pathology. Magnetic Resonance Imaging. Spinal Neoplasms / radionuclide imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Diphosphonates. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / radionuclide imaging. Organotechnetium Compounds. Radionuclide Imaging. Retrospective Studies. Spinal Cord Compression. Young Adult

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  • (PMID = 19530588.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Organotechnetium Compounds; 0 / technetium 99m methylene bisphosphonate
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56. Ak H, Ulu MO, Sar M, Albayram S, Aydin S, Uzan M: Adult intramedullary mature teratoma of the spinal cord: review of the literature illustrated with an unusual example. Acta Neurochir (Wien); 2006 Jun;148(6):663-9; discussion 669
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  • [Title] Adult intramedullary mature teratoma of the spinal cord: review of the literature illustrated with an unusual example.
  • In this manuscript the authors have reviewed the adult intramedullary lesions of the spinal cord published in the literature that are harbouring the characteristics of a mature teratoma and analysed the results with respect to histopathology, epidemiology, diagnostic methods and treatment.
  • [MeSH-major] Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / physiopathology. Teratoma / diagnosis. Teratoma / physiopathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Decompression, Surgical. Diagnosis, Differential. Female. Germ Layers / pathology. Humans. Laminectomy. Male. Middle Aged. Neck Pain / diagnosis. Neck Pain / etiology. Neck Pain / physiopathology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / radiotherapy. Neurosurgical Procedures. Paraparesis / diagnosis. Paraparesis / etiology. Paraparesis / physiopathology. Radiotherapy / standards. Sensation Disorders / diagnosis. Sensation Disorders / etiology. Sensation Disorders / physiopathology. Spinal Canal / pathology. Spinal Canal / surgery. Treatment Outcome

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  • (PMID = 16523223.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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57. Wu P, Davies FE, Boyd K, Thomas K, Dines S, Saso RM, Potter MN, Ethell ME, Shaw BE, Morgan GJ: The impact of extramedullary disease at presentation on the outcome of myeloma. Leuk Lymphoma; 2009 Feb;50(2):230-5
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  • [MeSH-major] Multiple Myeloma / complications. Multiple Myeloma / drug therapy. Spinal Cord Diseases / complications. Spinal Cord Diseases / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Female. Humans. Male. Middle Aged. Neoplasm Staging. Risk Factors. Survival Rate. Treatment Outcome

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  • [CommentIn] Leuk Lymphoma. 2014 Jul;55(7):1687-90 [24134777.001]
  • (PMID = 19197724.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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58. Zeng J, Liu H, Song Y: [Total spondylectomy and reconstruction for thoracolumbar spinal tumors with neurological deficit]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 May;21(5):445-8
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  • [Title] [Total spondylectomy and reconstruction for thoracolumbar spinal tumors with neurological deficit].
  • OBJECTIVE: To elucidate the surgical indications and treatment outcome of total spondylectomy and reconstruction for thoracolumbar spinal tumors with neurological deficit.
  • METHODS: From January 1999 to December 2005, 16 patients with thoracolumbar spinal tumors with neurological deficit were treated with total spondylectomy and reconstruction.
  • There were 10 cases of primary tumors of spine (4 giant cell tumor of bone, 3 chondrosarcoma, 2 recurrent aneurysmal bone cyst, and 1 osteosarcoma), and 6 cases of solitary metastasis of thoracic or lumbar spine.
  • Among the 10 patients with primary spinal tumor, nine patients survived with tumor-free, and one with osteosarcoma died because of lung metastases 18 months after surgery.
  • Among the 6 patients with spinal metastasis, three patients survived with tumor-free, and lung metastasis occurred in 1 case 10 months after surgery, two died because of multiple metastases of internal organs 10 months and 32 months after surgery.
  • CONCLUSION: Total spondylectomy and reconstruction is a safe and effective surgery for thoracolumbar spinal tumors with neurological deficit, with pain relief, neurological improvement and minimum tumor recurrence.
  • [MeSH-major] Lumbar Vertebrae / surgery. Reconstructive Surgical Procedures / methods. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Transplantation / methods. Chondrosarcoma / mortality. Chondrosarcoma / pathology. Chondrosarcoma / surgery. Decompression, Surgical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / prevention & control. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Young Adult

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  • (PMID = 17578278.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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59. Rushing EJ, Smith AB, Smirniotopoulos JG, Douglas AF, Zeng W, Azumi N: Occult leptomeningeal large cell medulloblastoma in an adult. Clin Neuropathol; 2009 May-Jun;28(3):188-92
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  • [Title] Occult leptomeningeal large cell medulloblastoma in an adult.
  • We report the first case of this entity in an adult that proved to be an unsuspected primary leptomeningeal tumor.
  • Cervical spine MRI performed the day prior to admission confirmed the diagnosis of Chiari I malformation and C3-4 disk herniation without spinal cord compression.
  • CONCLUSIONS: Our experience with this unique case illustrates the challenges of diagnosing a primary leptomeningeal neoplasm.
  • [MeSH-minor] Adult. Arnold-Chiari Malformation / complications. Fatal Outcome. Humans. Intervertebral Disc Displacement / complications. Magnetic Resonance Imaging. Male

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  • (PMID = 19537136.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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60. Luther N, Stetler WR Jr, Dunkel IJ, Christos PJ, Wellons JC 3rd, Souweidane MM: Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy. J Neurosurg Pediatr; 2010 Jan;5(1):61-7
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  • OBJECT: Endoscopic biopsy with concomitant third ventriculostomy (ETV) is a well-established diagnostic and therapeutic maneuver in patients presenting with noncommunicating hydrocephalus resulting from a tumor of the pineal region or posterior third ventricle.
  • Fenestration of the floor of the third ventricle theoretically provides a conduit for the subarachnoid dissemination of an intraventricular tumor.
  • METHODS: The authors conducted a review of all patients for whom an ETV and simultaneous endoscopic biopsy procedure or tumor resection had been performed at their institutions between 1995 and 2008.
  • All available postoperative clinical and radiographic data, including MR imaging of the brain and spinal cord, as well as CSF sampling were evaluated when available.
  • New leptomeningeal disease (1 yolk sac tumor and 1 pineoblastoma) occurred in 2 patients.
  • [MeSH-major] Biopsy / adverse effects. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / surgery. Endoscopy. Meningeal Neoplasms / secondary. Neoplasm Seeding. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Pinealoma / pathology. Pinealoma / surgery. Subarachnoid Space / pathology. Third Ventricle / pathology. Third Ventricle / surgery. Ventriculostomy / adverse effects
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20043737.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Akhaddar A, Ennouali H, Gazzaz M, Naama O, Elmostarchid B, Boucetta M: Idiopathic spinal epidural lipomatosis without obesity: a case with relapsing and remitting course. Spinal Cord; 2008 Mar;46(3):243-4
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  • [Title] Idiopathic spinal epidural lipomatosis without obesity: a case with relapsing and remitting course.
  • STUDY DESIGN: Case report of a rare form of idiopathic spinal epidural lipomatosis (SEL) manifesting with relapsing and remitting course.
  • Spinal magnetic resonance imaging revealed a fatty epidural mass extending from T4 to T9.
  • RESULTS: Pathological examination of the surgical specimen revealed nodules of mature fat cells without neoplasm.
  • [MeSH-major] Lipomatosis / diagnosis. Lipomatosis / pathology. Spinal Cord Diseases / diagnosis. Spinal Cord Diseases / pathology
  • [MeSH-minor] Adult. Decompression, Surgical. Demyelinating Diseases / diagnosis. Demyelinating Diseases / pathology. Diagnosis, Differential. Epidural Space. Humans. Magnetic Resonance Imaging. Male. Recurrence. Remission, Spontaneous. Thoracic Vertebrae / pathology

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  • (PMID = 17607308.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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62. Shono T, Natori Y, Morioka T, Torisu R, Mizoguchi M, Nagata S, Suzuki SO, Iwaki T, Inamura T, Fukui M, Oka K, Sasaki T: Results of a long-term follow-up after neuroendoscopic biopsy procedure and third ventriculostomy in patients with intracranial germinomas. J Neurosurg; 2007 Sep;107(3 Suppl):193-8
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  • All patients received chemotherapy and radiotherapy postoperatively, according to the regimen promulgated by the Japanese Pediatric Brain Tumor Study Group.
  • Only one patient had a recurrent lesion in the spinal cord 6 years after the initial treatment; however, this patient had undergone only the neuroendoscopic biopsy procedure without ETV.
  • The risk of tumor dissemination due to the neuroendoscopic procedures appears to be minimal when the appropriate chemotherapy and radiotherapy are provided postoperatively.
  • [MeSH-minor] Adolescent. Adult. Biopsy. Combined Modality Therapy. Endoscopy. Female. Follow-Up Studies. Humans. Hydrocephalus / pathology. Hydrocephalus / surgery. Magnetic Resonance Imaging. Male. Neoplasm Seeding. Postoperative Complications. Retrospective Studies. Third Ventricle / pathology. Third Ventricle / surgery. Treatment Outcome

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  • (PMID = 17918523.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Hiraoka M, Matsuo Y, Nagata Y: Stereotactic body radiation therapy (SBRT) for early-stage lung cancer. Cancer Radiother; 2007 Jan-Feb;11(1-2):32-5
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  • 1) solitary tumor less than 4 cm (T1-3N0M);.
  • 5) the peripheral tumor which dose constraints of mediastinal organs are maintained.
  • No grade II toxicities for spinal cord, bronchus, pulmonary artery, or esophagus were observed.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Dose Fractionation. Follow-Up Studies. Humans. Lung / radiation effects. Mediastinum / radiation effects. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Radiotherapy Planning, Computer-Assisted. Retrospective Studies. Survival Rate

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  • (PMID = 17158081.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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64. Arnold PM, Gust TD, Newell K: Intramedullary leiomyolipoma of the thoracic spine. Case report. J Neurosurg Spine; 2007 May;6(5):438-40
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  • The authors report a rare case of spinal intramedullary leiomyolipoma.
  • The histological characteristics and location of the neoplasm are unique, and the presentation, surgical management, and pathological characteristics of the lesion are discussed.
  • [MeSH-major] Leiomyoma / diagnosis. Leiomyoma / surgery. Lipoma / diagnosis. Lipoma / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Thoracic Vertebrae

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  • (PMID = 17542510.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Kiroglu Y, Benek B, Yagci B, Cirak B, Tahta K: Spinal cord compression caused by vertebral hemangioma being symptomatic during pregnancy. Surg Neurol; 2009 Apr;71(4):487-92; discussion 492
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  • [Title] Spinal cord compression caused by vertebral hemangioma being symptomatic during pregnancy.
  • CONCLUSION: According to literature review and our patient's outcome, pregnancy may induce neurologic symptoms and signs in silent spinal hemangiomas.
  • [MeSH-major] Hemangioma / pathology. Pregnancy Complications, Neoplastic / pathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Neoplasms / pathology. Thoracic Vertebrae / pathology
  • [MeSH-minor] Angiography. Back Pain / etiology. Cesarean Section. Embolization, Therapeutic. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / surgery. Paraplegia / etiology. Pregnancy. Reconstructive Surgical Procedures / instrumentation. Reconstructive Surgical Procedures / methods. Reoperation. Spinal Canal / pathology. Spinal Canal / radiography. Treatment Outcome. Vertebroplasty / instrumentation. Vertebroplasty / methods. Young Adult


66. Gong Y, Wang J, Bai S, Jiang X, Xu F: Conventionally-fractionated image-guided intensity modulated radiotherapy (IG-IMRT): a safe and effective treatment for cancer spinal metastasis. Radiat Oncol; 2008;3:11
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  • [Title] Conventionally-fractionated image-guided intensity modulated radiotherapy (IG-IMRT): a safe and effective treatment for cancer spinal metastasis.
  • BACKGROUND: Treatments for cancer spinal metastasis were always palliative.
  • In the original IMRT plans, the average dose of the planning target volume (PTV) was 61.9 Gy, with the spinal cord dose less than 49 Gy.
  • CONCLUSION: IG-IMRT provides a new approach to treat cancer spinal metastasis.
  • The precise positioning ensures the implementation of optimal IMRT plan, satisfying both the dose escalation of tumor targets and the radiation tolerance of spinal cord.
  • It might benefit the cancer patient with spinal metastasis.
  • [MeSH-major] Dose Fractionation. Radiotherapy / methods. Spinal Neoplasms / radiotherapy. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Safety. Treatment Outcome

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  • (PMID = 18426607.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2373792
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67. Medhkour A, Chan M: Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: a case report and review of the literature. Surg Neurol; 2005 Jun;63(6):576-82; discussion 582-3
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  • BACKGROUND: Spinal glioblastoma multiforme (GBM) is an uncommon entity and metastases are extremely rare.
  • Proper diagnosis via histopathologic and immunochemical staining with close clinical and radiological follow-up is important for the management of this very aggressive tumor.
  • CASE DESCRIPTION: The authors report the clinical features, histopathologic and immunochemical staining characteristics, as well as the radiographic evidence of a case of primary GBM of the conus medullaris with metastases to the whole spinal cord and brain in a 20-year-old man who presented with low back pain and bilateral lower extremity weakness and numbness.
  • Serial magnetic resonance scans, performed after the initial surgery, demonstrated enlargement of the primary GBM in the conus medullaris with metastases to the thoracic and cervical spinal cord as well as to the brain.
  • [MeSH-major] Brain Stem Neoplasms / secondary. Glioblastoma / secondary. Spinal Cord Compression / pathology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Brain Stem / pathology. Brain Stem / physiopathology. Cranial Nerve Diseases / etiology. Cranial Nerve Diseases / pathology. Cranial Nerve Diseases / physiopathology. Disease Progression. Fatal Outcome. Glial Fibrillary Acidic Protein / metabolism. Humans. Low Back Pain / etiology. Low Back Pain / pathology. Low Back Pain / physiopathology. Magnetic Resonance Imaging. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / physiopathology. Paresis / etiology. Paresis / pathology. Paresis / physiopathology. Rare Diseases. Respiratory Insufficiency / etiology. Respiratory Insufficiency / pathology. Respiratory Insufficiency / physiopathology. Spinal Cord / pathology. Spinal Cord / physiopathology

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  • (PMID = 15936395.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
  • [Number-of-references] 13
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68. Murphy BG, Shivaprasad HL: Ganglioneuroma of the brachial plexus in two cockatiels (Nymphicus hollandicus). Vet Pathol; 2008 Sep;45(5):690-2
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  • Ganglioneuroma involving the brachial plexus, paraspinal ganglia, and cervical-thoracic spinal cord was diagnosed in 2 adult cockatiels (Nymphicus hollandicus).
  • At necropsy, each bird had a unilateral, firm, gelatinous white to tan multilobular mass at the thoracic inlet expanding and partially obliterating the brachial plexus and cervical spinal cord.
  • Histologically, the masses were characterized by a locally infiltrative neoplasm comprised of spindloid cells forming streams and sheets with interspersed distinct neuron cell bodies consistent with ganglion cells.
  • [MeSH-major] Bird Diseases / pathology. Brachial Plexus / pathology. Cockatoos. Ganglioneuroma / veterinary. Peripheral Nervous System Neoplasms / veterinary. Spinal Cord Neoplasms / veterinary

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  • (PMID = 18725475.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Makuria AT, Henderson FC, Rushing EJ, Hartmann DP, Azumi N, Ozdemirli M: Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor. J Neurooncol; 2007 Apr;82(2):199-205
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  • [Title] Oligodendroglioma with neurocytic differentiation versus atypical extraventricular neurocytoma: a case report of unusual pathologic findings of a spinal cord tumor.
  • We report pathologic findings of an unusual spinal cord tumor from a 33-year-old male patient which showed hybrid features of oligodendroglioma and extraventricular neurocytoma.
  • Histologic examination revealed a clear cell neoplasm containing ganglion-like cells and calcifications, prompting the differential diagnosis of oligodendroglioma and extraventricular neurocytoma.
  • The proliferation index (using antibody MIB1) of the tumor was approximately 30%.
  • [MeSH-major] Neurocytoma / pathology. Oligodendroglioma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 17039400.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Gong HY, Yu JM, Fu Z, Li BS, Li JB, Liu TH: [Impact of PET/CT on precise radiotherapy planning for non-small cell lung cancer]. Zhonghua Zhong Liu Za Zhi; 2006 Jan;28(1):54-7
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  • The gross tumor volume (GTV) was delineated and three-dimensional conformal radiotherapy (3D-CRT) planning was established with identical parameters based on CT image and PET/CT fused image, respectively.
  • The indexes including volume of GTV (V(GTV)), percentage of the total lung volume which received more than 20 Gy (V(20)), mean lung dose (MLD), tumor control probability (TCP), normal tissue complication probability (NTCP), and dose to spinal cord (Ds) were selected and evaluated.
  • 3. The differences of indexes including V(GTV) (P = 0.004), V(20) (P = 0.000) and MLD (P = 0.004) between the two radiotherapy plannings were statistically significant, whereas, the Ds, TCP and NTCP (left lung, right lung, skin and spinal cord) was not.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Tomography, X-Ray Computed


71. Sung KS, Sung SK, Choi HJ, Song YJ: Spinal intradural extramedullary mature cystic teratoma in an adult. J Korean Neurosurg Soc; 2008 Nov;44(5):334-7
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  • [Title] Spinal intradural extramedullary mature cystic teratoma in an adult.
  • Spinal intradural extramedullary teratoma is a rare condition that develops more commonly in children than in adults and may be associated with spinal dysraphism.
  • We report a rare case of adult-onset intradural extramedullary teratoma in the thoracolumbar spinal cord with no evidence of spinal dysraphism and without the history of prior spinal surgery.
  • The resected tumor was histopathologically diagnosed as a mature cystic teratoma.

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  • (PMID = 19119471.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2612572
  • [Keywords] NOTNLM ; Mature teratoma / Spinal cord neoplasm
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72. Perry R, Gonzales I, Finlay J, Zacharoulis S: Primary peripheral primitive neuroectodermal tumors of the spinal cord: report of two cases and review of the literature. J Neurooncol; 2007 Feb;81(3):259-64
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  • [Title] Primary peripheral primitive neuroectodermal tumors of the spinal cord: report of two cases and review of the literature.
  • The histopathologic diagnosis of this tumor is complex and has led to a variety of treatment approaches.
  • The distinction between central and peripheral type primary spinal cord PNETs has not always been made in the literature, leading to a paucity of data in this disease.
  • [MeSH-major] Neuroectodermal Tumors, Primitive, Peripheral / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / therapy. Neurosurgical Procedures

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  • (PMID = 17203398.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Mergan F, Jaubert F, Sauvat F, Hartmann O, Lortat-Jacob S, Révillon Y, Nihoul-Fékété C, Sarnacki S: Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus 8 detection analysis. J Pediatr Surg; 2005 Oct;40(10):1581-6
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  • [Title] Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus 8 detection analysis.
  • BACKGROUND/PURPOSE: Inflammatory myofibroblastic tumor (IMT) is considered as an intermediate neoplasm that may present malignant features.
  • Differential diagnosis with other tumor processes is sometimes difficult.
  • Human herpesvirus 8 (HHV-8) DNA sequences have been described in adult pulmonary IMTs and Epstein-Barr virus (EBV) has been reported in splenic and hepatic IMTs, suggesting the importance of both viruses in IMT development.
  • RESULTS: Tumors were located in the pulmonary lobe (n = 4), urinary tract (n = 4), mesentery or bowel (n = 4), hepatic lobe (n = 1), vena cava (n = 1), spinal cord (n = 1), and soft tissue (n = 1).
  • ALK was positive in 3 (18.8%) cases and EBV in 1 pulmonary and 1 bladder tumor, all of them without recurrence or metastasis.
  • Larger multicentric studies would be necessary to understand the prognostic significance of ALK, EBV, and HHV-8 and their relationships with the origins of the tumor.

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  • (PMID = 16226988.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
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74. Gómez-Esteban JC, Berganzo K, Tijero B, Barcena J, Zarranz JJ: Orthostatic hypotension associated with an epidermoid tumor of the IV ventricle. J Neurol; 2009 Aug;256(8):1357-9
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  • [Title] Orthostatic hypotension associated with an epidermoid tumor of the IV ventricle.
  • We report the case of a 32-year-old man with an epidermoid tumor of the fourth ventricle.
  • About 14 years later, he showed a tumor recurrence which was removed.
  • [MeSH-minor] Adult. Autonomic Pathways / physiopathology. Baroreflex / physiology. Blood Pressure / physiology. Brain Stem / physiopathology. Fourth Ventricle / pathology. Fourth Ventricle / physiopathology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / complications. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurologic Examination. Neurosurgical Procedures. Treatment Outcome. Ventriculoperitoneal Shunt. Ventriculostomy

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  • (PMID = 19353231.001).
  • [ISSN] 1432-1459
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
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75. Melcher I, Disch AC, Khodadadyan-Klostermann C, Tohtz S, Smolny M, Stöckle U, Haas NP, Schaser KD: Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: results by management with total en bloc spondylectomy. Eur Spine J; 2007 Aug;16(8):1193-202
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  • Primary malignant spinal tumors and solitary vertebral metastases of selected tumor entities in the thoracolumbar spine are indications for total en bloc spondylectomy (TES).
  • This study aimed to describe our oncological and surgical management and to analyze the treatment results by management with TES for extra- and intracompartmental solitary spinal metastases and primary malignant vertebral bone tumors.
  • [MeSH-major] Lumbar Vertebrae / surgery. Orthopedic Procedures / methods. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Quality of Life. Retrospective Studies. Treatment Outcome

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  • (PMID = 17252218.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2200785
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76. Salehpour F, Zeinali A, Vahedi P, Halimi M: A rare case of intramedullary cervical spinal cord meningioma and review of the literature. Spinal Cord; 2008 Sep;46(9):648-50
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  • [Title] A rare case of intramedullary cervical spinal cord meningioma and review of the literature.
  • [MeSH-major] Meningioma / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Cervical Vertebrae / anatomy & histology. Diagnosis, Differential. Disease Progression. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures. Paresis / etiology. Paresis / pathology. Paresis / physiopathology. Somatosensory Disorders / etiology. Somatosensory Disorders / pathology. Somatosensory Disorders / physiopathology. Treatment Outcome

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  • (PMID = 18227848.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 5
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77. Zarovnaya EL, Pallatroni HF, Hug EB, Ball PA, Cromwell LD, Pipas JM, Fadul CE, Meyer LP, Park JP, Biegel JA, Perry A, Rhodes CH: Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature. J Neurooncol; 2007 Aug;84(1):49-55
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  • [Title] Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature.
  • There have been only 17 cases of AT/RT in adults reported in the medical literature and the rarity of this tumor makes the diagnosis in adults difficult.
  • We describe a case of an AT/RT of the spinal cord in an adult.
  • An MRI demonstrated a mass lesion in the dorsal spinal cord extending from C4 to C6.
  • The patient underwent three additional surgical procedures for recurrent disease throughout the neuraxis secondary to leptomeningeal spread of the tumor.
  • To our knowledge, this is the first case of a spinal atypical teratoid/rhabdoid tumor in an adult fully documented with molecular, immunohistochemical, cytogenetic and autopsy findings.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. Chromosomes, Human, Pair 22 / genetics. DNA-Binding Proteins / genetics. Neoplasm Recurrence, Local / pathology. Rhabdoid Tumor / pathology. Spinal Cord Neoplasms / pathology. Teratoma / pathology. Transcription Factors / genetics
  • [MeSH-minor] Adult. Cervical Vertebrae. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Monosomy / diagnosis. Monosomy / genetics. SMARCB1 Protein

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  • (PMID = 17377740.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 Protein; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Number-of-references] 34
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78. Ziadi A, Saliba I: Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review. Auris Nasus Larynx; 2010 Oct;37(5):539-45
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  • [Title] Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review.
  • OBJECTIVES: The incidence of malignant peripheral nerve sheath tumor (MPNST) is approximately 0.001%.
  • We used the following Keywords: "malignant peripheral nerve sheath tumor", "cranial nerve", "neurosarcoma", "malignant schwannoma", "neurofibroma", "malignant neurofibroma" and "nerve tumor".
  • 13 cases were treated with radiotherapy for tumor recurrence and metastasis.
  • Metastasis to the spinal cord is the most frequent one.
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Transformation, Neoplastic / pathology. Child. Child, Preschool. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / radiotherapy. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / radiotherapy. Neurofibroma / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / radiotherapy. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / radiotherapy. Neurofibromatosis 2 / surgery. Radiotherapy, Adjuvant. Spinal Neoplasms / mortality. Spinal Neoplasms / pathology. Spinal Neoplasms / secondary. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20399579.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
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79. Orford M, Mean R, Lapathitis G, Genethliou N, Panayiotou E, Panayi H, Malas S: Generation of an ABCG2(GFPn-puro) transgenic line--a tool to study ABCG2 expression in mice. Biochem Biophys Res Commun; 2009 Jun 26;384(2):199-203
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  • We show that ABCG2 is expressed in neural progenitors of the developing forebrain and spinal cord and in embryonic and adult endothelial cells of the brain.
  • [MeSH-minor] ATP Binding Cassette Transporter, Sub-Family G. Alleles. Animals. Antimetabolites, Antineoplastic / pharmacology. Cell Nucleus / metabolism. Drug Resistance, Neoplasm / genetics. Enhancer Elements, Genetic. Green Fluorescent Proteins / biosynthesis. Green Fluorescent Proteins / genetics. Mice. Promoter Regions, Genetic. Puromycin / pharmacology

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  • (PMID = 19393620.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATP Binding Cassette Transporter, Sub-Family G; 0 / ATP-Binding Cassette Transporters; 0 / Abcg3 protein, mouse; 0 / Antimetabolites, Antineoplastic; 147336-22-9 / Green Fluorescent Proteins; 4A6ZS6Q2CL / Puromycin
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80. Raz E, Antonelli M, Pichierri A, Consoli A, Giangaspero F, Fiorelli M: 35 year-old man with falcine tumor. Brain Pathol; 2010 Sep;20(5):987-8
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  • [Title] 35 year-old man with falcine tumor.
  • Macroscopically, the surgical specimen was whitish, soft, well circumscribed and measured 1.6 cm in diameter; microscopic features showed a neoplasm with high cellularity, presence of mitotic figures, without necrosis or microvascular proliferation; the neoplasm was reactive for glial fibrillary acidic protein and MIB-1 index was about 15%.
  • PLA is a very rare lesion that arises in the leptomeninges of the brain or spinal cord with no involvement of intraparenchymatous tissue.
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 20695870.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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81. Pakasa NM, Pasquier B, Chambonnière ML, Morrison AL, Khaddage A, Perret AG, Dumollard JM, Barral FG, Péoc'h M: Atypical presentations of solitary fibrous tumors of the central nervous system: an analysis of unusual clinicopathological and outcome patterns in three new cases with a review of the literature. Virchows Arch; 2005 Jul;447(1):81-6
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  • The intraspinal tumor occurred at T5-T7 in a patient with multiple café-au-lait spots, was predominantly myxoid and developed a second similar lesion at S3-S5 14 years later.
  • The MiB 1 index was lower in the second tumor.
  • [MeSH-major] Brain Neoplasms / pathology. Fibroma / pathology. Sella Turcica / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Second Primary

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  • (PMID = 15926073.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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82. Uff CE, Galloway M, Bradford R: Metastatic atypical choroid plexus papilloma: a case report. J Neurooncol; 2007 Mar;82(1):69-74
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  • Choroid plexus papillomas (CPPs) are rare adult tumours and metastatic disease is even less common, more typically associated with choroid plexus carcinoma.
  • [MeSH-major] Brain Neoplasms / pathology. Glioma / secondary. Neoplasm Recurrence, Local / pathology. Papilloma, Choroid Plexus / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / surgery. Fatal Outcome. Fourth Ventricle / pathology. Humans. Male. Neoplasm Metastasis / pathology

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  • (PMID = 16955222.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Chamberlain MC, Johnston SK, Glantz MJ: Neoplastic meningitis-related prognostic significance of the Karnofsky performance status. Arch Neurol; 2009 Jan;66(1):74-8
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  • MAIN OUTCOME MEASURES: Groups were matched on age, primary tumor, site of NM disease (cranial nerves or spinal cord), treatment (radiotherapy and chemotherapy; systemic and intraventricular), and absence of cerebrospinal fluid compartmentalization, NM-related encephalopathy, and neuroradiographic bulky central nervous system disease.
  • Primary tumor histologic diagnoses included breast cancer (20 patients), non-Hodgkin lymphoma (10 patients), lung cancer (10 patients), melanoma (8 patients), and others (12 patients).
  • At presentation, NM revealed cranial neuropathy (30 patients) or spinal cord dysfunction (39 patients).
  • All the patients received intraventricular chemotherapy, and 49 received concurrent tumor-specific systemic chemotherapy.
  • [MeSH-minor] Adult. Aged. Cohort Studies. Decision Support Techniques. Drug Therapy / standards. Female. Humans. Male. Meningeal Neoplasms / mortality. Meningeal Neoplasms / secondary. Meningeal Neoplasms / therapy. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Patient Selection. Predictive Value of Tests. Prognosis. Radiotherapy / standards. Retrospective Studies. Survival Rate. Treatment Failure. Withholding Treatment / standards

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  • (PMID = 19139302.001).
  • [ISSN] 1538-3687
  • [Journal-full-title] Archives of neurology
  • [ISO-abbreviation] Arch. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Narayana A, Yamada J, Berry S, Shah P, Hunt M, Gutin PH, Leibel SA: Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results. Int J Radiat Oncol Biol Phys; 2006 Mar 1;64(3):892-7
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  • A comparative dosimetric analysis revealed that regardless of tumor location, IMRT did not significantly improve target coverage compared with three-dimensional planning.
  • However, IMRT resulted in a decreased maximum dose to the spinal cord, optic nerves, and eye by 16%, 7%, and 15%, respectively, owing to its improved dose conformality.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brain / radiation effects. Disease Progression. Female. Glioblastoma / radiotherapy. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Oligodendroglioma / radiotherapy. Radiotherapy Dosage. Retrospective Studies

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  • (PMID = 16458777.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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85. Ulrich CT, Sommerlad D, Szelenyi A, Seifert V, Marquardt G: Concurrent schwannoma and intradural neuroma after resection of a cauda equina schwannoma. A case report and first description. Acta Neurochir (Wien); 2010 Jun;152(6):1061-3; discussion 1063
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  • CONCLUSIONS: Neuroma should be considered in the differential diagnosis of spinal lesions, particularly in the assumption of recurrence.
  • [MeSH-major] Cauda Equina / surgery. Neoplasms, Multiple Primary / surgery. Neurilemmoma / surgery. Neuroma / surgery. Peripheral Nervous System Neoplasms / surgery. Postoperative Complications / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Microsurgery. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / diagnosis. Neoplasm, Residual / surgery. Reoperation

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  • (PMID = 19834641.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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86. Sandalcioglu IE, Gasser T, Asgari S, Lazorisak A, Engelhorn T, Egelhof T, Stolke D, Wiedemayer H: Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients. Spinal Cord; 2005 Jan;43(1):34-41
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  • [Title] Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients.
  • OBJECTIVE: To analyze factors with impact on the functional outcome for patients with surgically treated intramedullary spinal cord tumors (IMSCT) and to point out characteristics of the different histological entities.
  • Functional outcome was analyzed depending on histological features, age, tumor localization and the extension of involved spinal segments.
  • Complete tumor removal was achieved in 65 cases (83.3%) and subtotal resection in nine cases.
  • Although there was no outcome difference with respect to the age and tumor extension, thoracically located IMSCTs proved to harbor an increased risk of postoperative surgical morbidity.
  • [MeSH-major] Astrocytoma / surgery. Dermoid Cyst / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Outcome Assessment (Health Care). Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae / surgery. Child. Child, Preschool. Female. Germany. Humans. Infant. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis / pathology. Postoperative Complications / pathology. Postoperative Complications / physiopathology. Prevalence. Risk Factors. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 15326473.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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87. Tseng HM, Kuo LT, Lien HC, Liu KL, Liu MT, Huang CY: Prolonged survival of a patient with cervical intramedullary glioblastoma multiforme treated with total resection, radiation therapy, and temozolomide. Anticancer Drugs; 2010 Nov;21(10):963-7
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  • Total resection of the tumor was performed at the C2-C6 level by laminoplasty with miniplate, followed by chemoradiotherapy (focal irradiation dose of 5000, at 200 cGy per fraction for over a period of 5 weeks) with concomitant temozolomide (75 mg/m2).
  • Histologic examination of the resected tumor confirmed GBM.
  • The tumor consisted of a markedly pleomorphic neoplasm measuring 4.6 cm×2.6 cm×1.7 cm and characterized by necrosis, atypical mitotic figures, and endothelial proliferation.
  • Recurrence in the cervical spine without brain GBM metastasis was identified 25 months after operation, and temozolomide chemotherapy was reinitiated; however, the tumor progressed, and the patient died 33 months after operation.
  • We suggest that, in addition to potential factors of tumor biology, multimodal treatment consisting of total resection of intramedullary GBM coupled with radiation therapy and temozolomide may have prolonged the survival of this patient.
  • [MeSH-major] Cervical Vertebrae. Dacarbazine / analogs & derivatives. Glioblastoma. Neurosurgical Procedures. Radiotherapy. Spinal Cord Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / adverse effects. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Disease-Free Survival. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging


88. Campos WK, Linhares MN: Sporadic intramedullary spinal cord hemangioblastoma in a newborn. Pediatr Neurosurg; 2010;46(5):385-9
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  • [Title] Sporadic intramedullary spinal cord hemangioblastoma in a newborn.
  • BACKGROUND: Hemangioblastomas (HB) are rare lesions accounting for 2% of all spinal cord tumors.
  • Spinal cord HB are usually diagnosed in adult patients and their incidence in early infancy is an extreme rarity.
  • MRI of the spine revealed an intramedullary tumor extending from level T6 to T12.
  • RESULTS: The tumor was excised completely, using standard microsurgical techniques via a posterior approach.
  • The histological diagnosis was spinal cord HB.
  • CONCLUSION: A review of the literature revealed that this neoplasm is composed of 3 major cell types: endothelial cells, pericytes and stromal cells.
  • Complete microsurgical removal is the treatment of choice for spinal cord HB because the tumor is benign.
  • To the best of our knowledge, sporadic spinal cord HB at this age has not been reported so far.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21389752.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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89. Chen KW, Yang HL, Lu J, Liu JY, Chen XQ: Prognostic factors of sacral chordoma after surgical therapy: a study of 36 patients. Spinal Cord; 2010 Feb;48(2):166-71
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  • Data regarding age, gender, tumor size, tumor location, and type of surgery, surgical margins, surrounding muscle invasion, radiation therapy, and recurrences were reviewed and analyzed statistically.
  • CDFS was found statistically longer in patients whose tumor highest level at or below S3 compared with above S3 (P=0.047).
  • CONCLUSIONS: The higher level of tumor involvement, invasion into the surrounding muscle, incomplete excision, and inadequate surgical margins are poor prognostic factors.
  • Resecting the tumor completely with wide surgical margins may provide a better prognosis for these patients.
  • [MeSH-major] Chordoma / diagnosis. Chordoma / surgery. Sacrum. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prognosis. Regression Analysis. Reoperation. Retrospective Studies. Young Adult

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  • (PMID = 19621022.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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90. Rades D, Schild SE: Dose-response relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: a review of the literature. J Neurooncol; 2006 May;77(3):311-4
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  • [Title] Dose-response relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: a review of the literature.
  • CTR is less frequent with spinal melanocytomas than with cerebral melanocytomas.
  • This study of 49 spinal melanocytoma patients was performed to define an appropriate radiation dose after ITR.
  • All reported spinal melanocytoma cases were reviewed for extent of surgery, radiotherapy (total dose, dose per fraction), and outcome.
  • The recurrence rates after CTR would mandate the use of post-operative radiotherapy in all spinal meningeal melanocytoma cases.
  • [MeSH-major] Dose Fractionation. Melanoma / radiotherapy. Meningeal Neoplasms / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Cohort Studies. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Survival Analysis

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  • (PMID = 16328723.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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91. Horn EM, Nakaji P, Coons SW, Dickman CA: Surgical treatment for intramedullary spinal cord melanocytomas. J Neurosurg Spine; 2008 Jul;9(1):48-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment for intramedullary spinal cord melanocytomas.
  • Spinal meningeal melanocytomas are rare lesions that are histologically benign and can behave aggressively, with local infiltration.
  • The authors present their experience with intramedullary spinal cord melanocytomas consisting of 3 cases, which represents the second largest series in the literature.
  • A retrospective chart review was performed following identification of all spinal melanocytomas treated at the author's institution, based on information obtained from a neuropathology database.
  • The charts were reviewed for patient demographics, surgical procedure, clinical outcome, and long-term tumor progression.
  • Three patients were identified in whom spinal melanocytoma had been diagnosed between 1989 and 2006.
  • The patients' ages were 37, 37, and 48 years, and the location of their tumor was C1-3, T9-10, and T-12, respectively.
  • With these cases added to the available literature, the evidence strongly suggests that complete resection is the treatment of choice for spinal melanocytomas.
  • [MeSH-major] Nevus, Pigmented / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Cervical Vertebrae. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 18590410.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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92. Iványi JL, Marton E, Plander M, Gyánó G, Czumbil L, Tóth C: [Therapeutic management of central nervous system lymphomas in a single hematological institute]. Orv Hetil; 2009 Oct 18;150(42):1937-44
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  • PATIENTS AND METHODS: During this period (mean follow-up of 13.2 months) from 427 patients with newly diagnosed non-Hodgkin's lymphomas, 22 primary central nervous system lymphoma was diagnosed (5.15%, 16 cerebral and 6 spinal cord lymphoma cases).
  • In case of partial response, boost irradiation for the tumor bed was also given.
  • RESULTS: Complete remission has been achieved in 9 patients with cerebral and in 4 patients with spinal cord lymphoma (13/22; 59.0%), however, one relapsed patient became resistant and later expired, despite salvage therapy.
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy. Chemotherapy, Adjuvant. Cyclophosphamide / administration & dosage. Cytarabine / administration & dosage. Dexamethasone / administration & dosage. Disease Progression. Doxorubicin / administration & dosage. Drug Administration Schedule. Epidural Space. Female. Humans. Hungary / epidemiology. Male. Methotrexate / administration & dosage. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Positron-Emission Tomography. Prednisone / administration & dosage. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Rituximab. Salvage Therapy / methods. Survival Analysis. Tomography, X-Ray Computed. Treatment Outcome. Vincristine / administration & dosage

  • Hazardous Substances Data Bank. CYTARABINE .
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  • Hazardous Substances Data Bank. DOXORUBICIN .
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  • (PMID = 19812012.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 04079A1RDZ / Cytarabine; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; CHOP protocol
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93. Polli FM, Salvati M, Miscusi M, Delfini R, Giangaspero F: Neurocytoma of the spinal cord: report of three cases and review of the literature. Acta Neurochir (Wien); 2009 Jun;151(6):569-74; discussion 574
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  • [Title] Neurocytoma of the spinal cord: report of three cases and review of the literature.
  • The spinal cord is a very rare location for extra-ventricular neurocytomas.
  • To date, eight cases of neurocytoma of the spinal cord have been described.
  • [MeSH-major] Neurocytoma / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age of Onset. Child. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures. Postoperative Complications / etiology. Radiotherapy. Sex Distribution. Syringomyelia / etiology. Syringomyelia / pathology. Syringomyelia / surgery. Treatment Outcome

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  • (PMID = 19387541.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 23
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94. Schor NF: Pharmacotherapy for adults with tumors of the central nervous system. Pharmacol Ther; 2009 Mar;121(3):253-64
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  • Tumors of the adult central nervous system are among the most common and most chemoresistant neoplasms.
  • Malignant tumors of the brain and spinal cord collectively account for approximately 1.3% of all cancers and 2.2% of all cancer-related deaths.

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  • (PMID = 19091301.001).
  • [ISSN] 0163-7258
  • [Journal-full-title] Pharmacology & therapeutics
  • [ISO-abbreviation] Pharmacol. Ther.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS038569; United States / NINDS NIH HHS / NS / NS038569-10; United States / NCI NIH HHS / CA / CA074289-09; United States / NCI NIH HHS / CA / R01 CA074289-09; United States / NCI NIH HHS / CA / R01 CA074289; United States / NINDS NIH HHS / NS / R01 NS038569-10
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 132
  • [Other-IDs] NLM/ NIHMS103661; NLM/ PMC2782733
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95. Ceresoli GL, Cattaneo GM, Castellone P, Rizzos G, Landoni C, Gregorc V, Calandrino R, Villa E, Messa C, Santoro A, Fazio F: Role of computed tomography and [18F] fluorodeoxyglucose positron emission tomography image fusion in conformal radiotherapy of non-small cell lung cancer: a comparison with standard techniques with and without elective nodal irradiation. Tumori; 2007 Jan-Feb;93(1):88-96
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  • METHODS: CT-based gross tumor volume (GTVCT) was first contoured by a single observer without knowledge of PET results.
  • Rival plans were compared for each patient with respect to dose to the normal tissues (spinal cord, healthy lungs, heart and esophagus).
  • RESULTS: The addition of PET-modified TNM staging in 10/21 enrolled patients (48%); 3/21 were shifted to palliative treatment due to detection of metastatic disease or large tumor not amenable to high-dose radiotherapy.
  • Comparing no ENI and PET plans, no statistically significant difference was observed, except for maximum point dose to the spinal cord Dmax, which was significantly lower in PET plans.
  • [MeSH-minor] Adult. Aged. Female. Fluorodeoxyglucose F18. Humans. Image Processing, Computer-Assisted. Lymph Nodes / diagnostic imaging. Lymph Nodes / radiation effects. Male. Mediastinum / diagnostic imaging. Middle Aged. Neoplasm Staging. Radiation Dosage


96. MacDonald TJ, Arenson EB, Ater J, Sposto R, Bevan HE, Bruner J, Deutsch M, Kurczynski E, Luerssen T, McGuire-Cullen P, O'Brien R, Shah N, Steinbok P, Strain J, Thomson J, Holmes E, Vezina G, Yates A, Phillips P, Packer R: Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933. Cancer; 2005 Dec 15;104(12):2862-71
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  • The authors conclude that these commonly used HDCT regimens provide no additional clinical benefit to conventional treatment in HGA, regardless of the amount of measurable residual tumor.
  • [MeSH-minor] Adolescent. Adult. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / radiotherapy. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Humans. Male. Neoplasm Staging. Probability. Prognosis. Prospective Studies. Radiotherapy, High-Energy. Reference Values. Risk Assessment. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiotherapy. Survival Analysis. Time Factors. Treatment Outcome

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16315242.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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97. Passarin MG, Vattemi E, Musso AM, Romito S, Moretto G, Ghimenton C, Iuzzolino P, Doglioni C, Pedersini R: Intracranial granulocytic sarcoma after chemotherapy for pineal germinoma and testicular cancer. J Clin Oncol; 2008 Sep 20;26(27):4507-9
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  • [MeSH-major] Brain Neoplasms / diagnosis. Meningeal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / therapy. Pinealoma / therapy. Sarcoma, Myeloid / diagnosis. Spinal Cord Neoplasms / secondary. Testicular Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Germinoma / diagnosis. Germinoma / therapy. Humans. Male. Neoplasm Staging. Orchiectomy. Remission Induction


98. Tekkök IH: Addendum to "aggressive spinal germinoma with ascending metastases". J Neurooncol; 2006 Jul;78(3):327
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  • [Title] Addendum to "aggressive spinal germinoma with ascending metastases".
  • [MeSH-major] Brain Neoplasms / secondary. Germinoma / secondary. Neoplasm Seeding. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cervical Vertebrae. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 16575533.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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99. Huey KA, Roy RR, Zhong H, Lullo C: Time-dependent changes in caspase-3 activity and heat shock protein 25 after spinal cord transection in adult rats. Exp Physiol; 2008 Mar;93(3):415-25
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  • [Title] Time-dependent changes in caspase-3 activity and heat shock protein 25 after spinal cord transection in adult rats.
  • Thus, the purpose of the present study was to determine whether there are any changes in Hsp25, pHsp25 and caspase-3 activity among rat muscles having different fibre type compositions and functions [soleus, adductor longus (AL), plantaris and tibialis anterior (TA)] at 0 (control), 1, 8 or 28 days after a complete spinal cord transection (ST).
  • Thus, the effects of ST on Hsp25 and caspase-3 are muscle specific and time dependent, factors that should be considered in developing any intervention to maintain muscle mass after a spinal cord injury.

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  • (PMID = 18156166.001).
  • [ISSN] 0958-0670
  • [Journal-full-title] Experimental physiology
  • [ISO-abbreviation] Exp. Physiol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR049855-01A1; United States / NIAMS NIH HHS / AR / R03 AR049855-01A1; United States / NINDS NIH HHS / NS / NS 16333; United States / NIAMS NIH HHS / AR / R03 AR 049855; United States / NIAMS NIH HHS / AR / R03 AR049855
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HSP27 Heat-Shock Proteins; 0 / Heat-Shock Proteins; 0 / Hspb1 protein, rat; 0 / Neoplasm Proteins; EC 3.4.22.- / Casp3 protein, rat; EC 3.4.22.- / Caspase 3
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100. Kyriakides AE, Lalam RK, El Masry WS: Acute spontaneous spinal subdural hematoma presenting as paraplegia: a rare case. Spine (Phila Pa 1976); 2007 Oct 1;32(21):E619-22
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  • [Title] Acute spontaneous spinal subdural hematoma presenting as paraplegia: a rare case.
  • OBJECTIVES: To report an unusual case of spontaneous spinal subdural hematoma and to review relevant literature and discuss the etiology, pathogenesis, clinical features, imaging, and prognosis.
  • SUMMARY OF BACKGROUND DATA: Spontaneous spinal subdural hematoma with no underline pathology is a very rare condition.
  • MRI revealed an anterior subdural hematoma from T2-T6 with cord compression.
  • CONCLUSION: Spinal subdural hematoma (SSDH) is uncommon and can be caused by abnormalities of coagulation, blood dyscrasias, or trauma, underlying neoplasm, and arteriovenous malformation.
  • [MeSH-major] Hematoma, Subdural, Spinal / diagnosis. Paraplegia / diagnosis
  • [MeSH-minor] Acute Disease. Adult. Diagnosis, Differential. Humans. Male

  • Genetic Alliance. consumer health - Paraplegia.
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  • (PMID = 17906565.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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