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1. Gavin Quigley D, Farooqi N, Pigott TJ, Findlay GF, Pillay R, Buxton N, Jenkinson MD: Outcome predictors in the management of spinal cord ependymoma. Eur Spine J; 2007 Mar;16(3):399-404
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  • [Title] Outcome predictors in the management of spinal cord ependymoma.
  • The aim of this study was to determine predictors of functional outcome and survival in a retrospective cohort of spinal cord ependymomas treated at a single institution.
  • Twenty-six patients who underwent treatment of spinal cord ependymoma at a single institution were retrospectively analysed.
  • Extent of resection and the use of adjuvant radiotherapy did not influence PFS or OS; however, early diagnosis and treatment are paramount in the management of spinal ependymoma if a good functional outcome is to be achieved.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Combined Modality Therapy. Data Interpretation, Statistical. Disease-Free Survival. Humans. Middle Aged. Predictive Value of Tests. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 16865377.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2200709
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2. Alkhani A, Blooshi M, Hassounah M: Outcome of surgery for intramedullary spinal ependymoma. Ann Saudi Med; 2008 Mar-Apr;28(2):109-13
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  • [Title] Outcome of surgery for intramedullary spinal ependymoma.
  • BACKGROUND AND OBJECTIVES: Ependymoma is the most frequently encountered intramedullary tumor.
  • This study was designed to define prognostic factors that affect clinical outcome after surgical resection of spinal intramedullary ependymoma.
  • PATIENTS AND METHODS: The medical records, radiological and pathological studies of all patients with intramedullary spinal ependymomas treated surgically in one institution were reviewed retrospectively.
  • Spinal myxopapillary ependymomas were excluded.
  • RESULTS: Surgery was performed on 17 patients (14 males, 3 females, mean age of 42+/-15 years) with spinal ependymoma.
  • CONCLUSIONS: Preoperative neurological status was the only statistically significant factor in determining the postoperative neurological outcome of patients with spinal intramedullary ependymomas.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Neoplasm Recurrence, Local / epidemiology. Neurologic Examination. Prognosis. Regression Analysis. Retrospective Studies. Treatment Outcome

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  • (PMID = 18398287.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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3. Szpak GM, Lewandowska E, Schmidt-Sidor B, Pasennik E, Modzelewska J, Stepień T, Zdaniuk G, Kulczycki J, Wierzba-Bobrowicz T: Giant cell ependymoma of the spinal cord and fourth ventricle coexisting with syringomyelia. Folia Neuropathol; 2008;46(3):220-31
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  • [Title] Giant cell ependymoma of the spinal cord and fourth ventricle coexisting with syringomyelia.
  • This report presents a case of widespread intramedullary giant cell ependymoma arising from the central canal of the C4 segment of the spinal cord in a 28-year-old man admitted to hospital with tetraplegia and signs of increased intracranial pressure, eight months after surgical spinal cervical decompression without tetraplegia improvement.
  • Magnetic resonance imaging and autopsy revealed a tumour extending from segment C3/C4 of the spinal cord to the lower half of the fourth ventricle with coexisting syringomyelia.
  • This slow-growing ependymoma of low-grade malignancy exhibited unusual morphology as well as degenerative and ischaemic changes.
  • The morphological diagnostic criteria of unusual giant-cell variant of ependymoma and tumour-related syringomyelia in adults are discussed, based on the presented case and a review of the literature.

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  • (PMID = 18825598.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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4. Naruse T, Matsuyama Y, Ishiguro N: Cyclooxygenase-2 expression in ependymoma of the spinal cord. J Neurosurg Spine; 2007 Mar;6(3):240-6
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  • [Title] Cyclooxygenase-2 expression in ependymoma of the spinal cord.
  • The expression of COX-2 in spinal ependymomas, however, has not been studied.
  • The authors evaluated COX-2 expression in ependymoma of the spinal cord.
  • METHODS: Sixteen ependymoma samples obtained in patients undergoing surgery between 1995 and 2004 were utilized for immunohistochemical studies to evaluate COX-2 and vascular endothelial growth factor (VEGF) expression.
  • Seven (43.8%) of the 16 ependymoma specimens expressed COX-2.
  • CONCLUSIONS: The results of the present study indicate that COX-2 expression may promote angiogenesis through VEGF expression in ependymomas of the spinal cord.
  • It is suggested that the use of selective COX-2 inhibitors may provide a new therapeutic strategy for spinal cord ependymomas due to their inhibition of the COX-2-mediated angiogenesis.
  • [MeSH-major] Cyclooxygenase 2 / metabolism. Ependymoma / enzymology. Spinal Cord Neoplasms / enzymology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neovascularization, Pathologic / enzymology. Statistics, Nonparametric. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 17355023.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 1.14.99.1 / Cyclooxygenase 2
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5. Barbagallo GM, Caltabiano R, Parisi G, Albanese V, Lanzafame S: Giant cell ependymoma of the cervical spinal cord: case report and review of the literature. Eur Spine J; 2009 Jul;18 Suppl 2:186-90
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  • [Title] Giant cell ependymoma of the cervical spinal cord: case report and review of the literature.
  • They develop from the ependymal cells that line the ventricular cavities of the brain and the central canal of the spinal cord, as well as from ependymal clusters in the filum terminale.
  • Giant cell ependymoma (GCE) is a rare subtype, with few cases reported, mostly in the brain.
  • We describe the case of a cervical spinal cord ependymoma with pleomorphic giant cells and focal calcifications occurring in a 25-year-old woman.
  • This case, the second giant-cell ependymoma to be described in the spinal cord and the first with focal calcifications, highlights the features of GCE and the discrepancy between the worrisome histological appearance, the surgical findings and the clinical relatively good prognosis.
  • [MeSH-major] Cervical Vertebrae. Ependymoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 18820954.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2899556
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6. O'Shaughnessy J, Bussières A: Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. J Can Chiropr Assoc; 2006 Dec;50(4):244-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report.
  • Cervical, thoracic and lumbar spinal radiographs were deemed unremarkable.
  • A magnetic resonance imaging (MRI) study was performed and revealed an expansive intramedullary lesion between C6 and T1 suggesting a differential diagnosis of spinal cord ependymoma or astrocytoma.
  • Pathological report confirmed a diagnosis of ependymoma.
  • In the presence of subtle clinical signs, clinicians should keep a high index of suspicion for spinal cord tumours.

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  • (PMID = 17549184.001).
  • [ISSN] 0008-3194
  • [Journal-full-title] The Journal of the Canadian Chiropractic Association
  • [ISO-abbreviation] J Can Chiropr Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC1840009
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7. Barton VN, Donson AM, Kleinschmidt-DeMasters BK, Birks DK, Handler MH, Foreman NK: Unique molecular characteristics of pediatric myxopapillary ependymoma. Brain Pathol; 2010 May;20(3):560-70
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  • [Title] Unique molecular characteristics of pediatric myxopapillary ependymoma.
  • Myxopapillary ependymoma (MEPN) generally can be cured by gross total surgical resection and usually manifest a favorable prognosis.
  • Unique molecular features of MEPN were investigated by using microarray technology to compare the gene expression of five pediatric MEPN to 24 pediatric intracranial ependymoma (EPN).
  • The upregulation of three genes of interest, homeobox B13 (HOXB13), neurofilament, light polypeptide (NEFL) and PDGFR alpha, was further studied by immunohistochemistry in a larger cohort that included adult MEPN and EPN specimens.
  • Protein expression in MEPN was compared to subependymoma, spinal EPN, intracranial EPN and normal fetal and adult ependyma.
  • Spinal and intracranial EPN generally expressed weak or focal staining.
  • [MeSH-major] Ependymoma / genetics. Ependymoma / metabolism. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Spinal Cord Neoplasms / genetics. Spinal Cord Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Cohort Studies. Female. Humans. Male. Retrospective Studies

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  • (PMID = 19793339.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins
  • [Other-IDs] NLM/ PMC2871180
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8. Shintaku M, Nagata N, Itoh H: Tanycytic ependymoma of the spinal cord with anaplastic cytological features. Brain Tumor Pathol; 2009;26(1):7-10
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  • [Title] Tanycytic ependymoma of the spinal cord with anaplastic cytological features.
  • In a 43-year-old man, an intramedullary spinal cord tumor spreading from the level of the T2 to T5 vertebrae was subtotally resected.
  • This is the first documentation of tanycytic ependymoma in which tumor cells showed anaplastic cytological features.
  • [MeSH-major] Ependymoma / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Anaplasia / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / immunology. Magnetic Resonance Imaging. Male

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  • (PMID = 19408091.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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9. Higgins GS, Smith C, Summers DM, Statham PX, Erridge SC: Myxopapillary ependymoma with intracranial metastases. Br J Neurosurg; 2005 Aug;19(4):356-8
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  • [Title] Myxopapillary ependymoma with intracranial metastases.
  • We report spontaneous seeding within the subarachnoid space from a myxopapillary ependymoma that progressed despite surgery and radiotherapy treatment.
  • [MeSH-major] Brain Neoplasms / secondary. Ependymoma / secondary. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Subarachnoid Space. Thoracic Vertebrae

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  • [CommentIn] Br J Neurosurg. 2006 Apr;20(2):114 [16753632.001]
  • (PMID = 16455546.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Sarikaya S, Acikgöz B, Tekkök IH, Güngen YY: Conus ependymoma with holocord syringohydromyelia and syringobulbia. J Clin Neurosci; 2007 Sep;14(9):901-4
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  • [Title] Conus ependymoma with holocord syringohydromyelia and syringobulbia.
  • We report a 24-year-old woman with an intramedullary conus ependymoma associated with holocord syringohydromyelia and syringobulbia.
  • The cause of syringohydromyelia accompanying intradural spinal cord tumors appears to be either direct blockade of the central canal or secondary interruption of the central canal flow by compression of the perimedullary cerebrospinal fluid flow.
  • [MeSH-major] Brain Stem Neoplasms / complications. Ependymoma / complications. Spinal Neoplasms / complications. Syringomyelia / complications
  • [MeSH-minor] Adult. Decompression, Surgical / methods. Female. Humans. Magnetic Resonance Imaging / methods

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  • (PMID = 17660060.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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11. Schuurmans M, Vanneste JA, Verstegen MJ, van Furth WR: Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases. J Neurooncol; 2006 Aug;79(1):57-9
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  • [Title] Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases.
  • Magnetic resonance imaging (MRI) of the cervical spine revealed an extramedullary tumor with severe spinal cord compression.
  • Further imaging showed a second lumbar spinal tumor.
  • Two years after surgery, an intracranial extracerebral metastasis was found, without evidence of spinal recurrence.
  • [MeSH-major] Brain Neoplasms / secondary. Ependymoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Lumbar Vertebrae. Magnetic Resonance Imaging. S100 Proteins / metabolism

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  • [Cites] J Neurosurg. 2004 Jan;100(1 Suppl Spine):75-9 [14748579.001]
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  • (PMID = 16614942.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / S100 Proteins
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12. Ulrich CT, Beck J, Seifert V, Marquardt G: Ependymoma of conus medullaris presenting as subarachnoid haemorrhage. Acta Neurochir (Wien); 2008 Feb;150(2):185-8
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  • [Title] Ependymoma of conus medullaris presenting as subarachnoid haemorrhage.
  • Subarachnoid haemorrhage (SAH) due to spinal ependymoma is very rare.
  • Lumbar puncture confirmed SAH but cerebral angiography was negative, and further diagnostic work-up revealed an ependymoma of the conus medullaris as the source of the haemorrhage.
  • Only 17 patients with spontaneous SAH due to a spinal ependymoma have been reported since 1958.
  • However, in cases of SAH and negative diagnostic findings for cerebral aneurysms or malformations, this aetiology should be considered and work-up of the spinal axis completed.
  • [MeSH-major] Ependymoma / complications. Ependymoma / diagnosis. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / diagnosis. Subarachnoid Hemorrhage / etiology
  • [MeSH-minor] Adult. Humans. Lumbar Vertebrae. Male

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  • (PMID = 18058061.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 17
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13. Sakai Y, Matsuyama Y, Katayama Y, Imagama S, Ito Z, Wakao N, Kanemura T, Yoshida G, Sato K, Ando T, Nakamura H, Kato F, Yukawa Y, Ito K, Ishiguro N: Spinal myxopapillary ependymoma: neurological deterioration in patients treated with surgery. Spine (Phila Pa 1976); 2009 Jul 1;34(15):1619-24
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  • [Title] Spinal myxopapillary ependymoma: neurological deterioration in patients treated with surgery.
  • OBJECTIVE.: To evaluate the postoperative outcomes of patients surgically treated for spinal myxopapillary ependymoma.
  • The heterogeneously enhanced ependymoma not only should be evaluated and treated meticulously, but also surgeons should not stick to total removal in infiltrated and adhering tumors as subtotally resected tumors with postoperative radiotherapy have not always recurred.
  • [MeSH-major] Ependymoma / surgery. Neurosurgical Procedures / adverse effects. Postoperative Complications / etiology. Spinal Cord / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Disease Progression. Female. Humans. Iatrogenic Disease / prevention & control. Magnetic Resonance Imaging. Male. Middle Aged. Polyradiculopathy / etiology. Polyradiculopathy / physiopathology. Polyradiculopathy / prevention & control. Spinal Cord Compression / etiology. Spinal Cord Compression / physiopathology. Spinal Cord Compression / prevention & control. Urinary Bladder, Neurogenic / etiology. Urinary Bladder, Neurogenic / physiopathology. Urinary Bladder, Neurogenic / prevention & control

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  • (PMID = 19564773.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Wahab SH, Simpson JR, Michalski JM, Mansur DB: Long term outcome with post-operative radiation therapy for spinal canal ependymoma. J Neurooncol; 2007 May;83(1):85-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long term outcome with post-operative radiation therapy for spinal canal ependymoma.
  • PURPOSE: A retrospective study was performed to evaluate the long term efficacy and safety of post-operative radiation therapy in the management of spinal canal ependymoma at our institution.
  • METHODS AND MATERIALS: Between 1954 and 1997, 22 patients with spinal canal ependymoma were treated with post-operative radiotherapy at our institution.
  • All patients underwent open biopsy with histologic diagnosis: 13 patients (59%) had ependymoma (WHO Grade II) and 9 patients (41%) had myxopapillary ependymoma (WHO Grade I).
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Canal. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17206474.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Andrade FG, de Aguiar PH, Matushita H, Taricco MA, Oba-Shinjo SM, Marie SK, Teixeira MJ: Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo. Arq Neuropsiquiatr; 2009 Sep;67(3A):626-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo.
  • METHOD: Data of clinical presentation, tumor location, duration of symptoms, degree of resection and complementary treatment of 34 patients with intracranial ependymoma and 31 with intramedullary ependymoma who underwent surgery in the last ten years were collected and correlated with the recurrence time and overall survival.
  • Data analyses of intramedullary ependymoma did not show correlation with overall survival and likelihood of recurrence.
  • [MeSH-major] Brain Neoplasms / surgery. Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Disease-Free Survival. Female. Hospitals, University. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult

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  • (PMID = 19722039.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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16. Spengos K, Vassilopoulou S, Tsivgoulis G, Karachalios G, Vassilopoulos D: Superficial siderosis due to a lumbar ependymoma mimicking adult-onset spinocerebellar ataxia. Clin Neurol Neurosurg; 2007 Oct;109(8):705-7
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  • [Title] Superficial siderosis due to a lumbar ependymoma mimicking adult-onset spinocerebellar ataxia.
  • Superficial siderosis (SS), as a result of chronic subarachnoid haemorrhage and haemosiderin deposition on the leptomeninges and subpial layers of the brain, cerebellum and spinal cord, can cause ataxia, pyramidal tract lesions and hearing deficits.
  • In cases with not pronounced hearing impairment adult-onset spinocerebellar ataxia can be considered as a differential diagnostic alternative.
  • A bleeding lumbar ependymoma was identified as a source of haemorrhage.
  • [MeSH-major] Ependymoma / complications. Siderosis / diagnosis. Siderosis / etiology. Spinal Cord Neoplasms / complications. Spinocerebellar Ataxias / diagnosis

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  • (PMID = 17555872.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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17. Arai T, Tani S, Isoshima A, Nagashima H, Joki T, Takahashi-Fujigasaki J, Abe T: [Intraoperative photodynamic diagnosis for spinal ependymoma using 5-aminolevulinic acid: technical note]. No Shinkei Geka; 2006 Aug;34(8):811-7
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  • [Title] [Intraoperative photodynamic diagnosis for spinal ependymoma using 5-aminolevulinic acid: technical note].
  • However, there is no report on photodynamic diagnosis (PDD) for spinal tumor.
  • In the present study, we evaluated the usefulness of PDD for spinal ependymoma using 5-ALA.
  • METHODS: Three patients with spinal ependymoma received oral doses of 5-ALA (20 mg/kg body weight) 2 hours before anesthesia induction.
  • CONCLUSION: The results of this study indicate the usefulness of 5-ALA-induced tumor fluorescence in guiding resection of spinal ependymoma.
  • 5-ALA-induced porphyrin fluorescence may label spinal ependymomas easily and clearly enough to enhance the completeness of tumor removal.
  • [MeSH-major] Aminolevulinic Acid. Ependymoma / diagnosis. Photosensitizing Agents. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Fluorescence. Humans. Intraoperative Period. Lighting. Magnetic Resonance Imaging. Male. Middle Aged. Porphyrins. Sensitivity and Specificity

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  • (PMID = 16910494.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 88755TAZ87 / Aminolevulinic Acid
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18. Adamson DC, Cummings TJ, Friedman AH: Myxopapillary ependymoma and fatty filum in an adult with tethered cord syndrome: a shared embryological lesion? Case report. Neurosurgery; 2005 Aug;57(2):E373; discussion E373
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxopapillary ependymoma and fatty filum in an adult with tethered cord syndrome: a shared embryological lesion? Case report.
  • OBJECTIVE AND IMPORTANCE: Myxopapillary ependymoma and fatty fila are traditionally thought to arise via completely different pathophysiologies.
  • CLINICAL PRESENTATION: A 28-year-old woman presented with low back pain, bilateral leg radiculopathies, and mild leg weakness suggestive of tethered cord syndrome.
  • Magnetic resonance imaging revealed lesions in the area of the conus medullaris consistent with a myxopapillary ependymoma and fatty filum.
  • CONCLUSION: We report an unusual case of a myxopapillary ependymoma coexisting with a fatty filum in an adult patient.
  • [MeSH-major] Cauda Equina / pathology. Ependymoma / complications. Lipoma / complications. Neural Tube Defects / complications. Spinal Cord Neoplasms / complications


19. Lensgraf AG, Young KJ: Ependymoma of the spinal cord presenting in a chiropractic practice: 2 case studies. J Manipulative Physiol Ther; 2006 Oct;29(8):676-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ependymoma of the spinal cord presenting in a chiropractic practice: 2 case studies.
  • OBJECTIVE: The purpose of this study is to discuss the cases of 2 patients with previously undiagnosed primary spinal cord tumors presenting in a private chiropractic clinical setting.
  • An overview of treatment and outcome for an ependymoma at T12-L1 and L1-L2 is discussed.
  • [MeSH-major] Back Pain / etiology. Chiropractic. Ependymoma / complications. Ependymoma / surgery. Referral and Consultation. Spinal Cord Neoplasms / complications
  • [MeSH-minor] Adult. Female. Humans. Intestines / physiopathology. Magnetic Resonance Imaging. Male. Manipulation, Chiropractic. Middle Aged. Motor Neuron Disease / etiology. Motor Neuron Disease / physiopathology. Neurosurgical Procedures. Radiotherapy, Adjuvant. Urinary Bladder / physiopathology

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  • (PMID = 17045102.001).
  • [ISSN] 1532-6586
  • [Journal-full-title] Journal of manipulative and physiological therapeutics
  • [ISO-abbreviation] J Manipulative Physiol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Karabatsou K, Crooks D, Williams D, Buxton N: Combination of myxopapillary ependymoma and fatty filum in a child with tethered cord syndrome. Case report. J Neurosurg Pediatr; 2008 May;1(5):386-8
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  • [Title] Combination of myxopapillary ependymoma and fatty filum in a child with tethered cord syndrome. Case report.
  • The authors present a case of a child with a tethered spinal cord associated with a myxopapillary ependymoma.
  • Magnetic resonance (MR) imaging demonstrated a fatty terminal filum and tethered cord.
  • The child underwent surgical exploration of the spine with resection of the fatty filum tissue and release of the cord.
  • Histological analysis of the fatty filum suggested the presence of a coexisting myxopapillary ependymoma.
  • This unusual combination has not previously been reported in children, and to the authors' knowledge there is only one reported case in an adult.
  • [MeSH-major] Cauda Equina. Ependymoma / pathology. Lipoma / pathology. Neural Tube Defects / pathology. Peripheral Nervous System Neoplasms / pathology


21. Gallia GL, Burger PC, Suk I, Bagley CA, Wolinsky JP, Garonzik IM, Gokaslan ZL: Concomitant conus medullaris ependymoma and filum terminale lipoma: case report. Neurosurgery; 2006 Jun;58(6):E1214; discussion E1214
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concomitant conus medullaris ependymoma and filum terminale lipoma: case report.
  • In this report, we describe the clinical presentation, radiographic findings, operative details, and pathological features of a patient with a conus medullaris ependymoma and a filum terminale lipoma.
  • Histopathological examination demonstrated a conus medullaris ependymoma and filum terminale lipoma.
  • CONCLUSION: Spinal cord ependymomas are almost exclusively single lesions and their coexistence with other pathological entities is rare.
  • In this report, we describe a patient with a concomitant conus medullaris ependymoma and filum terminale lipoma.
  • [MeSH-major] Cauda Equina / surgery. Ependymoma / surgery. Lipoma / surgery. Lumbar Vertebrae / surgery. Neoplasms, Multiple Primary / surgery. Peripheral Nervous System Neoplasms / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Laminectomy. Magnetic Resonance Imaging

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  • (PMID = 16723873.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Heuer GG, Stiefel MF, Bailey RL, Schuster JM: Acute paraparesis from hemorrhagic spinal ependymoma: diagnostic dilemma and surgical management. Report of two cases and review of the literature. J Neurosurg Spine; 2007 Dec;7(6):652-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute paraparesis from hemorrhagic spinal ependymoma: diagnostic dilemma and surgical management. Report of two cases and review of the literature.
  • Spinal ependymomas are a common type of primary spinal cord neoplasm that frequently occurs in the lumbar spine.
  • The pathological finding in each case was myxopapillary ependymoma.
  • [MeSH-major] Ependymoma / blood supply. Ependymoma / complications. Hemorrhage / etiology. Neurosurgical Procedures. Paraparesis / diagnosis. Spinal Cord Neoplasms / blood supply. Spinal Cord Neoplasms / complications
  • [MeSH-minor] Acute Disease. Adult. Female. Follow-Up Studies. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Nervous System Diseases / etiology. Treatment Outcome

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  • (PMID = 18074691.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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23. Benzagmout M, Boujraf S, Oulali N, Chbani L, Amarti A, Chakour K, Chaoui Mel F: Intradural extramedullary ependymoma: is there constantly a hormonal relationship? Surg Neurol; 2008 Nov;70(5):536-8; discussion 538
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  • [Title] Intradural extramedullary ependymoma: is there constantly a hormonal relationship?
  • BACKGROUND: Ependymoma is a glial tumor that occurs in the central nervous system.
  • The authors report a case of spinal intradural extramedullary ependymoma in a male and discuss its pathogenesis as well as its clinical, radiological, and therapeutical features.
  • Magnetic resonance imaging revealed an enhanced cervical intradural extramedullary tumor extending from the bulbomedullary junction to the C3 level, with severe spinal cord compression.
  • One year and half later, a local recurrence associated to a small cerebellar lesion was noticed justifying a second spinal intervention.
  • Both surgical interventions demonstrated an intradural extramedullary ependymoma without attachment to the spinal cord or to the dura mater.
  • [MeSH-major] Ependymoma / diagnosis. Ependymoma / etiology. Gonadal Steroid Hormones / physiology. Neoplasm Recurrence, Local / etiology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Adult. Cervical Vertebrae. Humans. Male. Sex Factors

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  • (PMID = 18207493.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones
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24. Armstrong PA, Polley LS: Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia. Int J Obstet Anesth; 2010 Jan;19(1):91-3
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  • [Title] Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia.
  • We report a case of an asymptomatic spinal cord neoplasm detected during the placement of a 25-gauge Whitacre spinal needle for spinal anesthesia before elective cesarean delivery.
  • Subarachnoid blood was repeatedly aspirated during otherwise uncomplicated induction of spinal anesthesia.
  • Magnetic resonance imaging revealed a spinal cord ependymoma in the lumbar spine.
  • Asymptomatic spinal cord neoplasms and ependymomas are reviewed.
  • [MeSH-major] Anesthesia, Obstetrical. Anesthesia, Spinal. Ependymoma / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Pregnancy. Subarachnoid Space / physiology. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19700305.001).
  • [ISSN] 1532-3374
  • [Journal-full-title] International journal of obstetric anesthesia
  • [ISO-abbreviation] Int J Obstet Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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25. Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutcheon I, Mahajan A, Maor MH, Woo SY: Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol; 2006 Nov;80(2):177-83
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  • [Title] Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center.
  • This study was undertaken to determine the disease outcomes in patients treated with surgery alone or surgery and adjuvant radiotherapy (RT) for myxopapillary ependymoma (MPE) of the spine.
  • [MeSH-major] Ependymoma / drug therapy. Ependymoma / radiotherapy. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neurologic Examination. Prognosis. Retrospective Studies. Salvage Therapy. Survival Analysis. Treatment Failure. Treatment Outcome

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  • [CommentIn] J Neurooncol. 2007 May;82(3):323-5 [17206476.001]
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  • (PMID = 16648988.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Marinovic T, Grahovac G, Habek M, Lambasa S, Tomac D: Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient. Clin Neuropathol; 2009 May-Jun;28(3):173-6
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  • [Title] Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient.
  • We report a patient who had pilocytic astrocytoma in the cerebellum and ependymoma in the cauda equina region, occurring simultaneously.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Ependymoma / pathology. Neoplasms, Multiple Primary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cauda Equina / pathology. Cauda Equina / surgery. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures

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  • (PMID = 19537133.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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27. Shu HK, Sall WF, Maity A, Tochner ZA, Janss AJ, Belasco JB, Rorke-Adams LB, Phillips PC, Sutton LN, Fisher MJ: Childhood intracranial ependymoma: twenty-year experience from a single institution. Cancer; 2007 Jul 15;110(2):432-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood intracranial ependymoma: twenty-year experience from a single institution.
  • BACKGROUND: Because few large studies of pediatric ependymoma treatment are available, the authors believed that a retrospective review of treatment outcomes from a single institution would yield potentially valuable information regarding potential prognostic factors.
  • METHODS: Medical records were reviews of patients with intracranial ependymoma who received their initial treatment at the Children's Hospital of Philadelphia (CHOP)/Hospital of the University of Pennsylvania (HUP) between January 1980 and December 2000.
  • Cervical spinal cord extension resulted in decreased OS primarily caused by failures outside the primary site.
  • Patients who had a favorable prognosis (aged >/=3 years, no dissemination or cord extension, complete resection, and radiation dose >/=54 grays [Gy]) had 5-year OS and PFS rates of 83.1% and 60.6%, respectively.
  • CONCLUSIONS: In this study of patients with pediatric intracranial ependymoma, OS and PFS rates were concordant with the rates published in other modern series.
  • [MeSH-major] Brain Neoplasms / pathology. Ependymoma / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Male. Prognosis. Survival Analysis. Treatment Outcome


28. Azarpira N, Rakei M, Mokhtari M: Cytologic findings in malignant ependymoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):1023-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic findings in malignant ependymoma: a case report.
  • Ependymomas are uncommon glial neoplasms of the CNS, arising from ependymal lining of the ventricular system and central canal of the spinal cord.
  • Anaplastic ependymoma is a rare tumor that causes diagnostic difficulties in imprint cytology because of variable cytomorphologic findings.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Ependymoma / pathology
  • [MeSH-minor] Cell Aggregation. Fatal Outcome. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Rosette Formation. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 21053591.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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29. Matsuyama Y, Sakai Y, Katayama Y, Imagama S, Ito Z, Wakao N, Sato K, Kamiya M, Yukawa Y, Kanemura T, Yanase M, Ishiguro N: Surgical results of intramedullary spinal cord tumor with spinal cord monitoring to guide extent of resection. J Neurosurg Spine; 2009 May;10(5):404-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical results of intramedullary spinal cord tumor with spinal cord monitoring to guide extent of resection.
  • OBJECT: The authors investigated the outcome of intramedullary spinal cord tumor surgery, focusing on the effect of preoperative neurological status on postoperative mobility and the extent of tumor excision guided by intraoperative spinal cord monitoring prospectively.
  • METHODS: Intramedullary spinal cord tumor surgery was performed in 131 patients between 1997 and 2007.
  • The tumor types included astrocytoma (12 cases), ependymoma (46 cases), hemangioblastoma (16 cases), cavernous hemangioma (17 cases), and others (15 cases overall: gangliocytoma, 1; germ cell tumor, 1; lymphoma, 3; neurinoma, 1; meningioma, 1; oligodendroglioma, 1; sarcoidosis, 2; glioma, 1; and unknown, 4).
  • However, the rate of postoperative deterioration was 31.5%, which is relatively high, and patients should be fully informed of this concern prior to intramedullary spinal cord tumor surgery.
  • [MeSH-major] Monitoring, Intraoperative / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / surgery. Child. Ependymoma / surgery. Female. Follow-Up Studies. Hemangioblastoma / surgery. Hemangioma, Cavernous / surgery. Humans. Male. Middle Aged. Postoperative Complications. Prognosis. Prospective Studies. Walking

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  • (PMID = 19442001.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Sangoi AR, Lim M, Dulai M, Vogel H, Chang S: Suprasellar giant cell ependymoma: a rare neoplasm in a unique location. Hum Pathol; 2008 Sep;39(9):1396-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suprasellar giant cell ependymoma: a rare neoplasm in a unique location.
  • Ependymomas are glial tumors that usually present in the posterior fossa in children and in the spinal cord in adults.
  • Giant cell ependymoma, a rare ependymal subtype only recently recognized as a diagnostic entity in the last decade, demonstrates pleomorphic giant cells admixed with features of typical ependymoma.
  • We describe the presentation and pertinent radiologic, histologic, immunologic, and ultrastructural findings in conjunction with relevant clinical implications of the first reported case of a suprasellar giant cell ependymoma occurring in a 34-year-old female 7 years after an initial diagnosis of a medullary ependymoma with rare atypical giant cells, a potential tumor seeding culprit.
  • [MeSH-major] Ependymoma / pathology. Supratentorial Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 18602668.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Yang YM, Jiang HZ, Sha C, Yuan QG, Wang CC, Xie HW, Zhou K, Wang DM: [Treatment of multisegmental intramedullary cervical spinal cord ependymomas]. Zhonghua Wai Ke Za Zhi; 2007 May 15;45(10):705-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of multisegmental intramedullary cervical spinal cord ependymomas].
  • OBJECTIVE: To discuss the possibility of microneurosurgery techniques in the treatment of multisegmental intramedullary cervical spinal cord ependymomas.
  • METHODS: The clinical data of 26 cases of multisegmental intramedullary cervical spinal cord ependymomas patients was reviewed and analyzed.
  • RESULTS: There were 14 cases of cervical spinal cord ependymomas, 12 cases of cervical and thoracic spinal cord ependymomas.
  • 4.5 spinal cord segments were involved in average.
  • CONCLUSIONS: Total resection of intramedullary cervical spinal cord ependymomas can be achieved by microneurosurgery.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cervical Vertebrae. Female. Follow-Up Studies. Humans. Male. Microsurgery / methods. Middle Aged. Neurosurgical Procedures / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 17688827.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Ma YT, Ramachandra P, Spooner D: Case report: primary subcutaneous sacrococcygeal ependymoma: a case report and review of the literature. Br J Radiol; 2006 May;79(941):445-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report: primary subcutaneous sacrococcygeal ependymoma: a case report and review of the literature.
  • We report a 37-year-old woman with a subcutaneous sacrococcygeal ependymoma with iliac lymph nodal metastasis at presentation.
  • [MeSH-major] Ependymoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers / analysis. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Ilium. Immunohistochemistry / methods. Lymphatic Metastasis. Magnetic Resonance Imaging. Radiotherapy, Adjuvant. Reoperation. S100 Proteins / analysis. Sacrococcygeal Region. Vimentin / analysis

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  • (PMID = 16632628.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 12
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33. Sun JJ, Wang ZY, Xie JC, Li ZD, Ma CC, Liu B, Zhao JZ: [Comparative analysis between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas]. Beijing Da Xue Xue Bao; 2010 Apr 18;42(2):183-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comparative analysis between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas].
  • OBJECTIVE: To comparatively analyze the different and common points between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas, such as the patient's age, gender, nervous functions and tumor location, longitudinal extension, and removed extent.
  • METHODS: Data were studied from 12 patients with multi-segments intramedullary spinal cord congenital tumors and 19 patients with multi-segments intramedullary spinal cord benign ependymomas who underwent microsurgery for the tumor using a posterior approach.
  • Those located at the conus accounted for almost 83.3% (10/12) multi-segments intramedullary spinal cord congenital tumors.
  • Because of the stiff adhesion with adjacent neural structures or penetrative growth in surrounding spinal marrow, some congenital tumors could not totally removed by force.
  • 78.9 (15/19) percent of multi-segments intramedullary spinal cord benign ependymomas were located at the cervical and cervicothoracic segments.
  • CONCLUSION: It is known from the clinical files that most multi-segments intramedullary spinal cord congenital tumors are found in young patients and most benign ependymomas in the middle-aged.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / congenital. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Microsurgery / methods. Neurosurgical Procedures / methods. Teratoma / congenital. Teratoma / diagnosis. Teratoma / surgery. Young Adult

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  • (PMID = 20396361.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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34. Vargas MI, Delavelle J, Jlassi H, Rilliet B, Viallon M, Becker CD, Lövblad KO: Clinical applications of diffusion tensor tractography of the spinal cord. Neuroradiology; 2008 Jan;50(1):25-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical applications of diffusion tensor tractography of the spinal cord.
  • The aim of this study was to assess the clinical utility of DTI in patients with diseases of the spinal cord.
  • Preliminary diagnosis of the patients suggested traumatic, tumorous, ischemic or inflammatory lesions of the spinal cord.
  • Diffusion tensor imaging showed a clear displacement and deformation of the white matter tracts at the level of the pathological lesions in the spinal cord.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Image Enhancement. Image Processing, Computer-Assisted. Nerve Fibers / pathology. Spinal Cord / pathology. Spinal Cord Diseases / diagnosis
  • [MeSH-minor] Adolescent. Adult. Anisotropy. Astrocytoma / diagnosis. Cervical Vertebrae. Ependymoma / diagnosis. Female. Humans. Intervertebral Disc Displacement. Male. Middle Aged. Multiple Myeloma / diagnosis. Neuromyelitis Optica / diagnosis. Spinal Cord Injuries / diagnosis. Spinal Cord Ischemia / diagnosis. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / secondary

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  • [Cites] AJNR Am J Neuroradiol. 2006 Jan;27(1):214-6 [16418387.001]
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  • (PMID = 17909776.001).
  • [ISSN] 1432-1920
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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35. Wu WX, Yu SZ, Sun CY, Wang Q, Jin SM, An TL: [Detection of chromosomal imbalance in ependymoma by comparative genomic hybridization]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):148-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection of chromosomal imbalance in ependymoma by comparative genomic hybridization].
  • Chromosomal +1q and +7p happened predominantly in intracranial EDMs with an averagely onset age of <or= 30 years, and +7 was only detected in spinal EDMs of patients over 30 years old, the differences were statistically significant (P < 0.05).
  • [MeSH-major] Brain Neoplasms / genetics. Chromosome Aberrations. Ependymoma / genetics. Spinal Cord Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Comparative Genomic Hybridization. DNA, Neoplasm / genetics. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19575847.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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36. Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M, Toyama Y, Chiba K: Surgical treatment of intramedullary spinal cord tumors: prognosis and complications. Spinal Cord; 2008 Apr;46(4):282-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of intramedullary spinal cord tumors: prognosis and complications.
  • OBJECTIVE: To evaluate our recent treatment strategy for intramedullary spinal cord tumors.
  • METHODS: We reviewed 68 cases of intramedullary tumors (ependymoma, 33; astrocytoma, 23; hemangioblastoma, 12), treated surgically between 1994 and 2003.
  • CONCLUSIONS: Predictors of good surgical outcome for intramedullary spinal cord tumors were histological grades of the tumors, surgical margins, and neurological status of the patient before surgery.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae. Child. Child, Preschool. Cohort Studies. Female. Humans. Male. Middle Aged. Postoperative Complications. Retrospective Studies. Survival Rate. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 17909556.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Volpp PB, Han K, Kagan AR, Tome M: Outcomes in treatment for intradural spinal cord ependymomas. Int J Radiat Oncol Biol Phys; 2007 Nov 15;69(4):1199-204

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes in treatment for intradural spinal cord ependymomas.
  • PURPOSE: Spinal cord ependymomas are rare tumors, accounting for <2% of all primary central nervous system tumors.
  • This study assessed the treatment outcomes for patients diagnosed with spinal cord ependymomas within the Southern California Kaiser Permanente system.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Radiotherapy, Adjuvant. Salvage Therapy / methods. Survival Rate. Treatment Outcome

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  • (PMID = 17689025.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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38. Taricco MA, Guirado VM, Fontes RB, Plese JP: Surgical treatment of primary intramedullary spinal cord tumors in adult patients. Arq Neuropsiquiatr; 2008 Mar;66(1):59-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of primary intramedullary spinal cord tumors in adult patients.
  • BACKGROUND: Primary spinal cord intramedullary tumors are rare and present with insidious symptoms.
  • The cervical cord was involved in 27% and thoracic in 42% of patients.
  • Ependymoma was the most frequent tumor (66.7%).
  • [MeSH-major] Cervical Vertebrae. Spinal Cord Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Treatment Outcome

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  • (PMID = 18392416.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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39. Abdel-Wahab M, Etuk B, Palermo J, Shirato H, Kresl J, Yapicier O, Walker G, Scheithauer BW, Shaw E, Lee C, Curran W, Thomas T, Markoe A: Spinal cord gliomas: A multi-institutional retrospective analysis. Int J Radiat Oncol Biol Phys; 2006 Mar 15;64(4):1060-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord gliomas: A multi-institutional retrospective analysis.
  • PURPOSE: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas.
  • PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01).
  • OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA.
  • [MeSH-major] Glioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Astrocytoma / mortality. Astrocytoma / radiotherapy. Astrocytoma / surgery. Child. Child, Preschool. Disease Progression. Ependymoma / mortality. Ependymoma / radiotherapy. Ependymoma / surgery. Female. Humans. Male. Middle Aged. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 16373081.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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40. Yang S, Yang X, Hong G: Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors. Spine (Phila Pa 1976); 2009 Nov 15;34(24):2705-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors.
  • STUDY DESIGN: A retrospective study of microsurgical treatment of intramedullary spinal cord tumors (IMSCT) was conducted.
  • RESULTS: In this group ependymoma was the commonest tumor (48.9%), the second most often seen being astrocytoma (35.6%).
  • In patients with ependymoma total resection was possible in 92.9% of patients, subtotal in 5.95%, and partial resection in 1.2%.
  • CONCLUSION: Most intramedullary spinal cord tumors need operative treatment as early as possible.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Aged. Child. Child, Preschool. Decompression, Surgical / methods. Disability Evaluation. Early Diagnosis. Female. Humans. Infant. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Outcome Assessment (Health Care). Pain / etiology. Paralysis / etiology. Retrospective Studies. Sensation Disorders / etiology. Treatment Outcome. Urinary Bladder, Neurogenic / etiology. Young Adult

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  • (PMID = 19910775.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Palacio FJ, Fornet I, Morillas P, López MA, Reina MA, López A: [Continuous subarachnoid analgesia and anesthesia for labor and cesarean section in a patient who had previously undergone surgery for ependymoma]. Rev Esp Anestesiol Reanim; 2008 Jun-Jul;55(6):371-4
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  • [Title] [Continuous subarachnoid analgesia and anesthesia for labor and cesarean section in a patient who had previously undergone surgery for ependymoma].
  • We report the case of a 38-year-old primipara who had undergone surgery 2 years earlier for an intradural ependymoma at L2-L3 and who was currently asymptomatic.
  • Continuous subarachnoid anesthesia may be considered the technique of choice where the patient has a history of spinal surgery.
  • [MeSH-major] Analgesia, Obstetrical. Anesthesia, Obstetrical. Anesthesia, Spinal. Cesarean Section
  • [MeSH-minor] Adult. Ependymoma / surgery. Female. Humans. Pregnancy. Spinal Cord Neoplasms / surgery

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  • (PMID = 18693664.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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42. Qin MJ, Peng B, Luo DD, Chen YD: [Microsurgical treatment of intramedullary tumor in the superior cervical spinal cord]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Feb;30(2):368-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microsurgical treatment of intramedullary tumor in the superior cervical spinal cord].
  • OBJECTIVE: To evaluate the curative effect of microsurgery for intramedullary tumor in the superior cervical spinal cord.
  • METHODS: The clinical manifestations, microsurgical methods and results were reviewed retrospectively in 12 patients with intramedullary tumors in the superior cervical spinal cord.
  • The spinal functions of patients, graded by McCormick scale system 3 months after the operations, were improved in 8 cases and remained unchanged in 4 cases.
  • CONCLUSION: Radical microneurosurgery is currently the best choice for the treatment of intradullary tumor in the superior cervical spinal cord.
  • [MeSH-major] Microsurgery / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Cervical Vertebrae. Ependymoma / diagnosis. Ependymoma / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20159725.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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43. Yanni DS, Ulkatan S, Deletis V, Barrenechea IJ, Sen C, Perin NI: Utility of neurophysiological monitoring using dorsal column mapping in intramedullary spinal cord surgery. J Neurosurg Spine; 2010 Jun;12(6):623-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Utility of neurophysiological monitoring using dorsal column mapping in intramedullary spinal cord surgery.
  • OBJECT: Intramedullary spinal cord tumors can displace the surrounding neural tissue, causing enlargement and distortion of the normal cord anatomy.
  • Standard anatomical landmarks may be misleading in patients with intramedullary spinal cord tumors due to cord rotation, edema, neovascularization, or local scar formation.
  • METHODS: A group of 10 patients with cervical and thoracic intramedullary spinal cord lesions underwent dorsal column mapping in which a strip electrode was used to define the midline.
  • After the laminectomy and durotomy, a custom-designed multielectrode grid was placed on the exposed dorsal surface of the spinal cord.
  • This strip electrode maps the amplitude gradient of conducted spinal somatosensory evoked potentials elicited by bilateral tibial nerve stimulation.
  • CONCLUSIONS: Dorsal column mapping is a useful technique for guiding the surgeon in locating the midline for myelotomy in intramedullary spinal cord surgery.
  • [MeSH-major] Evoked Potentials, Somatosensory / physiology. Monitoring, Intraoperative. Spinal Cord / physiopathology. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Electrodes. Ependymoma / surgery. Evoked Potentials, Motor / physiology. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20515347.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Lin YH, Huang CI, Wong TT, Chen MH, Shiau CY, Wang LW, Ming-Tak Ho D, Yen SH: Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy. J Neurooncol; 2005 Jan;71(2):205-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy.
  • PURPOSE: To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas.
  • METHODS AND MATERIALS: We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001.
  • Among them, 13 patients had ependymomas, 6 had myxopapillary ependymomas, and 1 had anaplastic ependymoma.
  • Among those with incomplete resection, 6 patients received postoperative radiotherapy to tumor bed and only one patient with anaplastic ependymoma received surgery alone.
  • One patient with anaplastic ependymoma and no postoperative radiotherapy developed leptomeningeal seeding 9 months after surgery.
  • CONCLUSION: Complete resection alone in spinal cord ependymoma can achieve excellent local control and survival.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / therapy. Nervous System / physiopathology. Retrospective Studies. Salvage Therapy. Survival Analysis. Treatment Outcome

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  • (PMID = 15690140.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Shrivastava RK, Epstein FJ, Perin NI, Post KD, Jallo GI: Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis. J Neurosurg Spine; 2005 Mar;2(3):249-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis.
  • OBJECT: Intramedullary spinal cord tumors (IMSCTs) in the older-age adult population pose complex management issues regarding the extent of resection and functional outcome, especially in terms of quality of life.
  • Historically, IMSCTs in the older adult population were treated with irradiation alone because it was assumed that functional recovery would be poor.
  • Ependymoma was the most common tumor (83%), and 55% were located in the thoracic spine.
  • The longer prodromal period in the older adult population may reflect the fact that their diagnosis and workup is inadequate.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 15796348.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Sun J, Wang Z, Li Z, Liu B: Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors. J Clin Neurosci; 2009 May;16(5):666-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors.
  • We aimed to prospectively analyze correlations between clinical features and histological classification of multi-segment intramedullary spinal cord tumors (MSICTs), and the extent of microsurgical resection and functional outcomes.
  • Correlation analyses were performed between functional outcome (IJOA score) and histological features, age, tumor location, and the longitudinal extent of spinal cord involvement.
  • Ependymoma was the most frequent MSICT type, seen in 22 of 56 patients (39%), followed by low grade astrocytoma (17 patients, 30%) and glioblastoma multiforme (3 patients, 5%).
  • Thus, MSICTs were most commonly seen in the medullo cervical and cervicothoracic regions, with ependymoma and low grade astrocytoma the most common tumour types.
  • [MeSH-major] Laminectomy / methods. Microsurgery / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neurologic Examination / methods. Outcome Assessment (Health Care). Prospective Studies. Spinal Cord / pathology. Spinal Cord / surgery. Young Adult

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  • (PMID = 19303302.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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47. Garcés-Ambrossi GL, McGirt MJ, Mehta VA, Sciubba DM, Witham TF, Bydon A, Wolinksy JP, Jallo GI, Gokaslan ZL: Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases. J Neurosurg Spine; 2009 Nov;11(5):591-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases.
  • OBJECT: With the introduction of electrophysiological spinal cord monitoring, surgeons have been able to perform radical resection of intramedullary spinal cord tumors (IMSCTs).
  • Pathological type included ependymoma in 51 cases, hemangioblastoma in 15, pilocytic astrocytoma in 16, WHO Grade II astrocytoma in 10, and malignant astrocytoma in 9.
  • A GTR resulted in improved PFS for hemangioblastoma (HR 0.004, p = 0.04) and ependymoma (HR 0.2, p = 0.02), but not astrocytoma.
  • A GTR should be attempted for ependymoma and hemangioblastoma, but it may not affect PFS for astrocytoma.
  • [MeSH-major] Hemangioblastoma / mortality. Hemangioblastoma / surgery. Neurosurgical Procedures. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / mortality. Astrocytoma / pathology. Astrocytoma / surgery. Disease Progression. Disease-Free Survival. Ependymoma / mortality. Ependymoma / pathology. Ependymoma / surgery. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Predictive Value of Tests. Prognosis. Recovery of Function. Retrospective Studies. Risk Factors. Therapeutics. Young Adult

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  • [CommentIn] J Neurosurg Spine. 2009 Nov;11(5):588-9; discussion 590 [19929362.001]
  • (PMID = 19929363.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Engelhard HH, Villano JL, Porter KR, Stewart AK, Barua M, Barker FG, Newton HB: Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina. J Neurosurg Spine; 2010 Jul;13(1):67-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina.
  • OBJECT Patients having a primary tumor of the spinal cord, spinal meninges or cauda equina, are relatively rare.
  • Pain was the most common presenting symptom, while the most common tumor types were meningioma (24.4%), ependymoma (23.7%), and schwannoma (21.2%).
  • [MeSH-major] Cauda Equina / pathology. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Chi-Square Distribution. Child. Child, Preschool. Ependymoma / epidemiology. Ependymoma / pathology. Ependymoma / surgery. Female. Humans. Infant. Male. Meningioma / epidemiology. Meningioma / pathology. Meningioma / surgery. Middle Aged. Neurilemmoma / epidemiology. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications / epidemiology. Prospective Studies. Radiotherapy, Adjuvant. Registries. Risk Factors. Treatment Outcome. United States / epidemiology

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  • (PMID = 20594020.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Manzano G, Green BA, Vanni S, Levi AD: Contemporary management of adult intramedullary spinal tumors-pathology and neurological outcomes related to surgical resection. Spinal Cord; 2008 Aug;46(8):540-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contemporary management of adult intramedullary spinal tumors-pathology and neurological outcomes related to surgical resection.
  • OBJECTIVES: To present our experience, over an 8-year period, with aggressive microsurgical resection of intramedullary spinal tumors in adults focusing on histology, microsurgical techniques, short-term neurological outcomes, complication avoidance and dorsal column dysfunction (DCD).
  • METHODS: We conducted a retrospective review of a series of adult patients with intramedullary spinal tumors treated with microsurgical excision at the University of Miami/Jackson Memorial Medical Center between January 1997 and September 2005.
  • CONCLUSION: We present a contemporary adult series of intramedullary spinal tumors.
  • [MeSH-major] Ependymoma. Neurosurgery / methods. Spinal Cord Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Microsurgery / methods. Middle Aged. Neurologic Examination. Retrospective Studies. Treatment Outcome

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  • (PMID = 18542096.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
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50. Tredway TL, Santiago P, Hrubes MR, Song JK, Christie SD, Fessler RG: Minimally invasive resection of intradural-extramedullary spinal neoplasms. Neurosurgery; 2006 Feb;58(1 Suppl):ONS52-8; discussion ONS52-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive resection of intradural-extramedullary spinal neoplasms.
  • OBJECTIVE: Spinal intradural-extramedullary neoplasms are uncommon lesions that usually cause pain or neurological deficit secondary to neural compression.
  • Histologically, five tumors were determined to be schwannomas and one was identified as a myxopapillary ependymoma.
  • [MeSH-major] Ependymoma / surgery. Minimally Invasive Surgical Procedures / methods. Spinal Cord Neoplasms / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Laminectomy / methods. Magnetic Resonance Imaging / methods. Male. Middle Aged. Treatment Outcome

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  • [CommentIn] Neurosurgery. 2006 Nov;59(5):E1152 [17143217.001]
  • (PMID = 16479629.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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51. Santamato A, Panza F, Ranieri M, Amoruso MT, Amoruso L, Frisardi V, Solfrizzi V, Fiore P: Effect of intrathecal baclofen, botulinum toxin type A and a rehabilitation programme on locomotor function after spinal cord injury: a case report. J Rehabil Med; 2010 Oct;42(9):891-4
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  • [Title] Effect of intrathecal baclofen, botulinum toxin type A and a rehabilitation programme on locomotor function after spinal cord injury: a case report.
  • OBJECTIVE: A few studies have reported the use of botulinum toxin injections after spinal cord injury, as this is the gold standard to treat focal spasticity.
  • CASE REPORT: A 38-year-old woman who had become paraplegic and care-dependent secondary to cervico-thoracic intramedullary ependymoma, presented 8 months later with painful lower limb spasticity, which was being treated with oral anti-spastic and benzodiazepine drugs with no therapeutic effect.
  • CONCLUSION: The use of botulinum toxin type A may be an important adjunctive therapy to increase the therapeutic effect of baclofen on spasticity in small muscles, resulting in a more focal effect, and improving the use of orthoses and the effectiveness of rehabilitation programmes in patients after spinal cord injury.
  • [MeSH-major] Baclofen / administration & dosage. Botulinum Toxins, Type A / administration & dosage. Neuromuscular Agents / administration & dosage. Spinal Cord Injuries / drug therapy
  • [MeSH-minor] Adult. Drug Therapy, Combination. Ependymoma / complications. Female. Gait. Humans. Injections, Intramuscular. Injections, Spinal. Muscle Relaxants, Central / administration & dosage. Muscle Spasticity / drug therapy. Spinal Neoplasms / complications. Treatment Outcome

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  • (PMID = 20878052.001).
  • [ISSN] 1651-2081
  • [Journal-full-title] Journal of rehabilitation medicine
  • [ISO-abbreviation] J Rehabil Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Muscle Relaxants, Central; 0 / Neuromuscular Agents; EC 3.4.24.69 / Botulinum Toxins, Type A; H789N3FKE8 / Baclofen
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52. Sandalcioglu IE, Gasser T, Asgari S, Lazorisak A, Engelhorn T, Egelhof T, Stolke D, Wiedemayer H: Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients. Spinal Cord; 2005 Jan;43(1):34-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients.
  • OBJECTIVE: To analyze factors with impact on the functional outcome for patients with surgically treated intramedullary spinal cord tumors (IMSCT) and to point out characteristics of the different histological entities.
  • Functional outcome was analyzed depending on histological features, age, tumor localization and the extension of involved spinal segments.
  • [MeSH-major] Astrocytoma / surgery. Dermoid Cyst / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Outcome Assessment (Health Care). Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae / surgery. Child. Child, Preschool. Female. Germany. Humans. Infant. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis / pathology. Postoperative Complications / pathology. Postoperative Complications / physiopathology. Prevalence. Risk Factors. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 15326473.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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53. Mobley B, Kalani MY, Harsh GR 4th, Edwards MS, Vogel H: Papillary tumor of the spinal cord: report of 2 cases. Am J Surg Pathol; 2009 Aug;33(8):1191-7
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  • [Title] Papillary tumor of the spinal cord: report of 2 cases.
  • Intramedullary spinal cord tumors constitute a small fraction of central nervous system tumors in the pediatric population; of these, the majority are ependymomas or astrocytomas.
  • We report 2 pediatric spinal cord tumor cases with unique morphologic and immunohistochemical features.
  • The clinical features, including propensity for recurrence and remote subarachnoid spread, and the pathologic features of these tumors are reminiscent of papillary tumor of the pineal region, ependymoma, and choroid plexus papilloma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Male. Neurosurgical Procedures. Radiotherapy

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  • (PMID = 19417584.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Joaquim AF, Santos MJ, Tedeschi H: Surgical management of intramedullary spinal ependymomas. Arq Neuropsiquiatr; 2009 Jun;67(2A):284-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of intramedullary spinal ependymomas.
  • BACKGROUND: Spinal intramedullary ependymoma is a rare disease with a wide range of clinical presentation, generally requiring surgical treatment.
  • [MeSH-major] Ependymoma / surgery. Microsurgery / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19547824.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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55. Eroes CA, Zausinger S, Kreth FW, Goldbrunner R, Tonn JC: Intramedullary low grade astrocytoma and ependymoma. Surgical results and predicting factors for clinical outcome. Acta Neurochir (Wien); 2010 Apr;152(4):611-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary low grade astrocytoma and ependymoma. Surgical results and predicting factors for clinical outcome.
  • INTRODUCTION: The optimal time point for surgery of intramedullary spinal astrocytomas and ependymomas is often debated on, as predicting factors are poorly defined.
  • MATERIAL AND METHODS: All consecutive adult patients with intramedullary astrocytomas or ependymomas (except filum terminale ependymomas) were included.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 20119838.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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56. Meneses MS, Leal AG, Periotto LB, Milano JB, Coelho-Net M, Sobral AC, Ramina R: Primary filum terminale ependymoma: a series of 16 cases. Arq Neuropsiquiatr; 2008 Sep;66(3A):529-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary filum terminale ependymoma: a series of 16 cases.
  • [MeSH-major] Cauda Equina / surgery. Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Laminectomy / methods. Magnetic Resonance Imaging. Male. Middle Aged. Young Adult

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  • (PMID = 18813713.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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57. Tekkök IH, Sav A: Aggressive spinal germinoma with ascending metastases. J Neurooncol; 2005 Nov;75(2):135-41
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  • [Title] Aggressive spinal germinoma with ascending metastases.
  • Initial spinal MR scans showed a sausage-like lesion that extended between L1 and S2.
  • The initial histopathological diagnosis was ependymoma.
  • After second surgery, 5,100 cGy of local spinal radiation was given since the pathologist believed that the new tumor exhibited anaplastic features.
  • Primary spinal germinomas are exceedingly rare.
  • A review of the literature revealed only 14 biopsy-proven spinal germinoma cases.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / pathology. Neoplasm Recurrence, Local / diagnosis. Reoperation. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Ependymoma / diagnosis. Follow-Up Studies. Humans. Lumbar Vertebrae / anatomy & histology. Magnetic Resonance Imaging. Male. Sacrum / anatomy & histology. Time Factors. Treatment Outcome

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  • (PMID = 16132516.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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58. Sala F, Palandri G, Basso E, Lanteri P, Deletis V, Faccioli F, Bricolo A: Motor evoked potential monitoring improves outcome after surgery for intramedullary spinal cord tumors: a historical control study. Neurosurgery; 2006 Jun;58(6):1129-43; discussion 1129-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Motor evoked potential monitoring improves outcome after surgery for intramedullary spinal cord tumors: a historical control study.
  • OBJECTIVE: The value of intraoperative neurophysiological monitoring (INM) during intramedullary spinal cord tumor surgery remains debated.
  • The historical control group consisted of 50 patients selected from among 301 patients who underwent intramedullary spinal cord tumor surgery, previously operated on by the same team without INM.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Evoked Potentials, Motor. Monitoring, Intraoperative. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Case-Control Studies. Child. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Muscle, Skeletal / physiopathology. Treatment Outcome

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  • (PMID = 16723892.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Milano MT, Johnson MD, Sul J, Mohile NA, Korones DN, Okunieff P, Walter KA: Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. J Neurooncol; 2010 May;98(1):83-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study.
  • To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE).
  • Patients with resected grade 2 spinal cord glioma who did not receive radiotherapy fared well with respect to OS and CSS.
  • For patients with spinal cord glioma, the variables of histology, grade, age and undergoing resection are significant predictors of outcome.
  • [MeSH-major] Glioma / classification. Glioma / epidemiology. SEER Program. Spinal Cord Neoplasms / classification. Spinal Cord Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Child. Child, Preschool. Female. Humans. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19898743.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Fassett DR, Pingree J, Kestle JR: The high incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients. Report of five cases and review of the literature. J Neurosurg; 2005 Jan;102(1 Suppl):59-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The high incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients. Report of five cases and review of the literature.
  • Four (80%) of these five patients suffered from disseminated disease of the central nervous system (CNS) at the time of presentation; this incidence is much higher than that reported in the combined adult and pediatric literature.
  • [MeSH-major] Brain Neoplasms / secondary. Ependymoma / pathology. Ependymoma / secondary. Neoplasm Metastasis. Spinal Cord Neoplasms / pathology


61. Barresi V, Cerasoli S, Vitarelli E, Donati R: Spinal intradural müllerianosis: a case report. Histol Histopathol; 2006 10;21(10):1111-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal intradural müllerianosis: a case report.
  • In this report we describe a case of spinal cord müllerianosis which occurred in a 42-year-old woman.
  • [MeSH-major] Endometriosis / pathology. Ependymoma / pathology. Mixed Tumor, Mullerian / pathology. Mullerian Ducts / pathology. Spinal Cord / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry

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  • (PMID = 16835833.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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62. Timothy J, Hanna SJ, Furtado N, Shanmuganathan M, Tyagi A: The use of titanium non-penetrating clips to close the spinal dura. Br J Neurosurg; 2007 Jun;21(3):268-71
Hazardous Substances Data Bank. TITANIUM .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The use of titanium non-penetrating clips to close the spinal dura.
  • We present the results of our initial experience in the use of non-penetrating titanium clips in the closure of spinal dura.
  • The commonest diagnoses were meningioma, ependymoma and neurofibroma.
  • Our early experience with the use of non-penetrating clips for the closure of the spinal dura is presented.
  • [MeSH-major] Dura Mater / surgery. Postoperative Complications / prevention & control. Spinal Cord / surgery. Surgical Instruments
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Subdural Effusion / etiology. Titanium. Treatment Outcome

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  • (PMID = 17612916.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] D1JT611TNE / Titanium
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63. Aghakhani N, David P, Parker F, Lacroix C, Benoudiba F, Tadie M: Intramedullary spinal ependymomas: analysis of a consecutive series of 82 adult cases with particular attention to patients with no preoperative neurological deficit. Neurosurgery; 2008 Jun;62(6):1279-85; discussion 1285-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal ependymomas: analysis of a consecutive series of 82 adult cases with particular attention to patients with no preoperative neurological deficit.
  • OBJECTIVE: Surgery should be considered for patients with intramedullary spinal ependymomas (ISE), particularly those presenting with a neurological deficit preoperatively.
  • [MeSH-major] Ependymoma / radiography. Ependymoma / surgery. Spinal Cord Neoplasms / radiography. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae. Cohort Studies. Female. Humans. Male. Middle Aged. Neck Pain / etiology. Paresthesia / etiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 18824994.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Rudà R, Gilbert M, Soffietti R: Ependymomas of the adult: molecular biology and treatment. Curr Opin Neurol; 2008 Dec;21(6):754-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ependymomas of the adult: molecular biology and treatment.
  • PURPOSE OF REVIEW: To review state of art and relevant advances in the molecular biology and management of ependymomas of the adult.
  • RECENT FINDINGS: Ependymomas of the adult are uncommon neoplasms of the central nervous system, and may occur either in the brain or the spinal cord.
  • Compared with intracranial ependymomas, spinal ependymomas are less frequent and exhibit a better prognosis.
  • Studies performed on genetic changes in ependymoma provide some insight into the pathogenesis and prognostic markers and yield new therapeutic targets, particularly focused on signal transduction modulators.
  • [MeSH-major] Ependymoma / genetics. Ependymoma / therapy. Molecular Biology / methods

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  • (PMID = 18989122.001).
  • [ISSN] 1350-7540
  • [Journal-full-title] Current opinion in neurology
  • [ISO-abbreviation] Curr. Opin. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 106
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65. Santi M, Quezado M, Ronchetti R, Rushing EJ: Analysis of chromosome 7 in adult and pediatric ependymomas using chromogenic in situ hybridization. J Neurooncol; 2005 Mar;72(1):25-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of chromosome 7 in adult and pediatric ependymomas using chromogenic in situ hybridization.
  • The present study utilizes chromogenic in situ hybridization (CISH), a relatively recent hybridization technique, to retrospectively examine chromosome 7-copy number in pediatric and adult ependymomas.
  • Of the 27 hybridizations, polysomy of chromosome 7 was detected in 10 out of 15 (66%) adult ependymomas, and in only three out of 12 (25%) pediatric lesions.
  • The authors conclude that (1) there are distinct genetic subsets of ependymoma, in particular, increases in copy number of chromosome 7 are almost exclusively found in myxopapillary ependymoma, and that (2) CISH is a rapid and sensitive method of stratifying morphological variants of ependymoma and potentially other central nervous system (CNS) tumors.
  • [MeSH-major] Brain Neoplasms / genetics. Chromosomes, Human, Pair 7 / genetics. Ependymoma / genetics. Ploidies. Spinal Cord Neoplasms / genetics
  • [MeSH-minor] Adult. Age Factors. Child. Child, Preschool. Chromogenic Compounds / analysis. Humans. In Situ Hybridization / methods. Infratentorial Neoplasms / classification. Infratentorial Neoplasms / genetics. Retrospective Studies

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  • (PMID = 15803371.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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66. Park P, Leveque JC, La Marca F, Sullivan SE: Dural closure using the U-clip in minimally invasive spinal tumor resection. J Spinal Disord Tech; 2010 Oct;23(7):486-9

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  • [Title] Dural closure using the U-clip in minimally invasive spinal tumor resection.
  • OBJECTIVE: To report an alternative to suture for dual closure in minimally invasive spinal surgery.
  • SUMMARY OF BACKGROUND DATA: Dural closure in minimally invasive spinal intradural tumor resection can be technically challenging.
  • METHODS: We report the results of 2 cases in which the U-clip device was used for dural closure after minimally invasive spinal resection of an intradural mass.
  • RESULTS: Two patients presented with spinal intradural tumors.
  • Patient 1 presented with severe upper back pain and was found to have an intradural extramedullary mass at T2 causing severe spinal cord compression.
  • CONCLUSIONS: Successful dural closure can be achieved using the U-clip device, thereby eliminating the difficulty associated with suture management and knot tying during minimally invasive spinal procedures.
  • [MeSH-major] Dura Mater / surgery. Ependymoma / surgery. Laminectomy / methods. Meningioma / surgery. Spinal Cord Neoplasms / surgery. Wound Closure Techniques / instrumentation
  • [MeSH-minor] Adult. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging. Surgical Instruments. Treatment Outcome

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  • (PMID = 20075749.001).
  • [ISSN] 1539-2465
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Gomez DR, Missett BT, Wara WM, Lamborn KR, Prados MD, Chang S, Berger MS, Haas-Kogan DA: High failure rate in spinal ependymomas with long-term follow-up. Neuro Oncol; 2005 Jul;7(3):254-9
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  • [Title] High failure rate in spinal ependymomas with long-term follow-up.
  • Data on spinal ependymomas are sparse, and prognostic factors remain controversial.
  • Thirty-seven patients with spinal cord ependymomas received postoperative radiation therapy from 1955 to 2001.
  • Local relapse rates for spinal ependymomas are higher than previously cited, with a large proportion of failures occurring more than five years after diagnosis.

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  • [Cites] Spinal Cord. 1999 Nov;37(11):753-9 [10578245.001]
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  • (PMID = 16053700.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA082103; United States / NCI NIH HHS / CA / U01 CA062399; United States / NCI NIH HHS / CA / CA 82103; United States / NCPDCID CDC HHS / CI / NCI UO1-CA62399
  • [Publication-type] Clinical Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1871913
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68. Han IH, Kuh SU, Kim JH, Chin DK, Kim KS, Yoon YS, Jin BH, Cho YE: Clinical approach and surgical strategy for spinal diseases in pregnant women: a report of ten cases. Spine (Phila Pa 1976); 2008 Aug 1;33(17):E614-9
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  • [Title] Clinical approach and surgical strategy for spinal diseases in pregnant women: a report of ten cases.
  • OBJECTIVE: To present the treatment guideline for spinal diseases in pregnant women.
  • SUMMARY OF BACKGROUND DATA: Treatment for spinal diseases in pregnant women is a special clinical challenge because of complex medical and surgical clinical problems.
  • METHODS: We retrospectively reviewed 10 patients who underwent surgery for spinal diseases, who were diagnosed during pregnancy at our hospital from February 1992 to October 2005.
  • Six patients had herniated lumbar discs, 3 patients had spinal tumors, and 1 patient had spinal tuberculosis.
  • One patient had recurrent intramedullary ependymoma at the C3-T2 level.
  • She had the preterm baby by vaginal delivery before spinal operation in gestational age 33 weeks and underwent tumor removal surgery.
  • CONCLUSION: In most spinal diseases, including HLD and tumors, prepartum surgical treatment can be safely performed maintaining pregnancy.
  • [MeSH-major] Neurosurgical Procedures / methods. Orthopedic Procedures / methods. Pregnancy Complications / surgery. Spinal Diseases / surgery
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Retrospective Studies


69. Katonis P, Kontakis G, Pasku D, Tzermiadianos M, Tzanakakis G, Hadjipavlou A: Intradural tumours of the lumbar spine presenting with low back pain: report of two cases and review of the literature. Acta Orthop Belg; 2008 Apr;74(2):282-8

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  • Two cases of spinal cord tumours (one schwannoma and one ependymoma) of the lumbar spine are reported.
  • The treatment with radical excision and posterolateral fusion, along with adjuvant radiation therapy in the case with ependymoma was successful, with follow-up of six and seven years respectively.
  • [MeSH-major] Ependymoma / surgery. Low Back Pain / etiology. Neurilemmoma / surgery. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Female. Humans. Lumbar Vertebrae. Male. Middle Aged

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  • (PMID = 18564491.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 26
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70. Qi Q, Chen ZQ, Guo ZQ, Li WS: [New type spinal osteotomy with cage inserting anteriorly and closing posteriorly to correct thoracolumbar kyphosis by a single posterior approach]. Zhonghua Wai Ke Za Zhi; 2006 Apr 15;44(8):551-5
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  • [Title] [New type spinal osteotomy with cage inserting anteriorly and closing posteriorly to correct thoracolumbar kyphosis by a single posterior approach].
  • OBJECTIVE: To evaluate the feasibility, safety and efficacy of surgical correction of thoracolumbar kyphosis, using the new type spinal osteotomy with cage inserting into the intervertebral gap anteriorly and closing posteriorly by a single posterior approach.
  • There were 3 cases of congenital kyphosis with scoliosis, 1 case of old spinal tuberculosis kyphosis, 2 cases of post-traumatic kyphosis, 1 case of ankylosing spondylitic kyphosis with old stress fracture and 1 case of iatrogenic kyphosis post-op of laminectomy due to the removal of ependymoma from cauda equina.
  • The main procedures of the new type spinal osteotomy consisted of temporary rod installation, trans-intervertebral spinal osteotomy, circumferential decompression of the spinal cord, dissection and complete cut of the anterior longitudinal ligament, spreading the intervertebral gap with the distraction forceps during the instrumentation correction maneuver and replaced by the cage filled with autograft bone inserting into the intervertebral gap, then the closing maneuver followed.
  • CONCLUSIONS: The new type spinal osteotomy with cage inserting anteriorly and closing posteriorly by a single posterior approach was a safe, reliable and effective surgical procedure for the treatment of the thoracolumbar kyphosis with the Cobb angle from 40 degrees to 90 degrees.
  • Compared with the other common spinal wedge osteotomies, the deformation danger, such as hanging down, kinking or dural buckling could be effectively prevented, a better correction rate is also achieved significantly with this new type procedure.
  • [MeSH-major] Kyphosis / surgery. Lumbar Vertebrae / surgery. Osteotomy / methods. Spinal Fusion / methods. Thoracic Vertebrae / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16784636.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Antoniadis G, Engelhardt M, Börm W, Richter HP, Rath SA: [Spinal intramedullary tumors. When is surgical treatment indicated?]. Nervenarzt; 2005 Feb;76(2):186-92
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  • [Title] [Spinal intramedullary tumors. When is surgical treatment indicated?].
  • Recurrences were observed in two patients with astrocytomas and one patient with ependymoma.
  • [MeSH-major] Nervous System Diseases / diagnosis. Nervous System Diseases / prevention & control. Preoperative Care / methods. Risk Assessment / methods. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Recovery of Function. Retrospective Studies. Risk Factors. Treatment Outcome

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  • [ISSN] 0028-2804
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72. Morgan RJ, Synold T, Mamelak A, Lim D, Al-Kadhimi Z, Twardowski P, Leong L, Chow W, Margolin K, Shibata S, Somlo G, Yen Y, Frankel P, Doroshow JH: Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors. Cancer Chemother Pharmacol; 2010 Oct;66(5):927-33
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  • [Title] Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.
  • The tumors included glioblastoma (6), anaplastic astrocytoma (2), metastatic non-small cell (3), small cell lung (2), and one each with medulloblastoma, ependymoma, and metastatic breast or colon carcinoma.

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  • (PMID = 20107803.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA033572; United States / NCI NIH HHS / CA / P30 CA033572-26; United States / NCI NIH HHS / CA / CA 33572
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 094ZI81Y45 / Tamoxifen; 7M7YKX2N15 / Topotecan; BG3F62OND5 / Carboplatin
  • [Other-IDs] NLM/ NIHMS335377; NLM/ PMC3265324
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73. Cosnard G, Duprez T, Grandin C, Hernalsteen D: [Intramedullary tumours and pseudotumours]. J Radiol; 2010 Sep;91(9 Pt 2):988-97
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  • Swelling of the spinal cord and/or enhancement after intravenous gadolinium administration are not always specific features of intramedullary tumour.
  • A tumour is characterized by its sagittal location, axial topography: central, lateral or exophytic, its size and size of the spinal canal, macroscopic components: calcium, fat, methemoglobin, melanin, hemosiderin, vascular pedicle, cystic component, enhancement after intravenous gadolinium administration, effect on the spinal cord tracts and edema.
  • Characteristics: astrocytoma is lateral and infiltrative, ependymoma is central with white matter tract displacement and hemosiderin cap, hemangioblastoma is postero-lateral and shows enhancement with a vascular pedicle, metastases are very edematous or leptomeningeal in location.
  • [MeSH-major] Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Spinal Cord Diseases / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Astrocytoma / diagnosis. Contrast Media / administration & dosage. Diagnosis, Differential. Ependymoma / diagnosis. Female. Hemangioblastoma / diagnosis. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / etiology. Humans. Lymphoma / diagnosis. Myelitis / diagnosis. Myelitis / etiology. Sensitivity and Specificity

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  • (PMID = 20814390.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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74. Bagley CA, Wilson S, Kothbauer KF, Bookland MJ, Epstein F, Jallo GI: Long term outcomes following surgical resection of myxopapillary ependymomas. Neurosurg Rev; 2009 Jul;32(3):321-34; discussion 334
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  • Myxopapillary ependymomas, a specific tumor variant of spinal cord ependymomas, occur most commonly in the lumbosacral region.
  • During the study period, 1,013 patients underwent surgery for spinal cord tumors.
  • Fifty-two of the patients had a myxopapillary ependymoma.
  • Fourteen pediatric patients were diagnosed with myxopapillary ependymoma.
  • The adult mean age was 38.7 years.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Arthritis, Experimental / etiology. Arthritis, Experimental / pathology. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Postoperative Complications / epidemiology. Postoperative Complications / pathology. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19221818.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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75. Dimopoulos VG, Fountas KN, Robinson JS: Familial intracranial ependymomas. Report of three cases in a family and review of the literature. Neurosurg Focus; 2006;20(1):E8
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  • A 54-year-old man with fourth ventricular ependymoma underwent resection of the tumor followed by radiation therapy.
  • His son presented at age 36 years with a fourth ventricular tanycytic ependymoma and underwent total resection of the ependymoma with postoperative radiation therapy.
  • The father's sister had been treated at another institution for a posterior fossa ependymoma.The association of ependymomas with molecular genetic alterations in chromosome 22 has been previously described.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Ependymoma / surgery. Family Health. Radiotherapy / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Review Literature as Topic

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  • (PMID = 16459998.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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76. Idowu MO, Rosenblum MK, Wei XJ, Edgar MA, Soslow RA: Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. Am J Surg Pathol; 2008 May;32(5):710-8
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  • [Title] Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein.
  • The adult extra-axial cases demonstrated more architectural variability than the CNS cases.
  • We observed that both the CNS and adult extra-axial ependymomas expressed GFAP diffusely, whereas only 9 stage III, high-grade ovarian serous papillary carcinomas stained with GFAP (2 strongly and diffusely and 7 exhibiting focally weak expression).
  • There were significant immunophenotypic differences between adult extra-axial and CNS ependymomas, with extra-axial cases preferentially expressing 34betaE12 (60% vs. 0%), CK18 (100% vs. 20%), CAM 5.2 (60% vs. 10%), CK7 (80% vs. 10%), ER (100% vs. 10%), and PR (80% vs. 20%).
  • Two spinal cord ependymomas expressed CK18, 1 expressed CK7, and 1 expressed CAM 5.2.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Central Nervous System Neoplasms / metabolism. Ependymoma / metabolism. Glial Fibrillary Acidic Protein / metabolism. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Immunoenzyme Techniques. Infant. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging

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  • (PMID = 18360284.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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77. Ginguené C, Champier J, Maallem S, Strazielle N, Jouvet A, Fèvre-Montange M, Ghersi-Egea JF: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) localize in the microvessels forming the blood-tumor barrier in ependymomas. Brain Pathol; 2010 Sep;20(5):926-35
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ependymomas are neuroepithelial tumors that arise from the ependymal layer bordering the cerebral ventricles and spinal canal.
  • Intracranial ependymoma represents a major encephalic tumor in children, while spinal ependymoma develops more frequently in adults.
  • The MRP1 transcript was expressed at a significantly higher level in spinal tumors than in intracranial tumors.
  • [MeSH-major] ATP-Binding Cassette Transporters / metabolism. Blood-Testis Barrier / metabolism. Cerebral Ventricle Neoplasms / pathology. Ependymoma / pathology. Microvessels / metabolism. Neoplasm Proteins / metabolism. P-Glycoprotein / metabolism. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Humans. Infant. Laminin / metabolism. Middle Aged. Models, Biological. P-Glycoproteins. Young Adult. von Willebrand Factor / metabolism

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  • (PMID = 20406235.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / ABCB1 protein, human; 0 / ABCG2 protein, human; 0 / Laminin; 0 / Neoplasm Proteins; 0 / P-Glycoprotein; 0 / P-Glycoproteins; 0 / von Willebrand Factor
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78. Gilbert MR, Ruda R, Soffietti R: Ependymomas in adults. Curr Neurol Neurosci Rep; 2010 May;10(3):240-7
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  • They occur most commonly in the spinal cord, where histopathologic evaluation is critical to differentiate the grade I myxopapillary ependymoma from the grade II ependymoma or grade III anaplastic ependymoma.
  • For myxopapillary ependymoma, complete removal while maintaining capsule integrity may be curative.
  • [MeSH-major] Central Nervous System Neoplasms. Ependymoma
  • [MeSH-minor] Adult. Epigenesis, Genetic. Humans

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  • (PMID = 20425040.001).
  • [ISSN] 1534-6293
  • [Journal-full-title] Current neurology and neuroscience reports
  • [ISO-abbreviation] Curr Neurol Neurosci Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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79. Parker W, Brodeur M, Roberge D, Freeman C: Standard and nonstandard craniospinal radiotherapy using helical TomoTherapy. Int J Radiat Oncol Biol Phys; 2010 Jul 1;77(3):926-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS AND MATERIALS: We first present a standard case of craniospinal irradiation in a patient with recurrent myxopapillary ependymoma (MPE) and follow this with 2 cases requiring differential dosing to multiple target volumes.
  • The final case presented is a patient with pronounced scoliosis who required spinal irradiation for recurrent MPE.
  • [MeSH-major] Ependymoma / radiotherapy. Medulloblastoma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Child. Humans. Neurofibromatosis 1 / complications. Radiation Injuries / prevention & control. Scoliosis / complications. Tomography, Spiral Computed / methods. Young Adult

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  • [Copyright] (c) 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1280; author reply 1280 [20970036.001]
  • (PMID = 20231076.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] United States
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80. Merchant TE, Pollack IF, Loeffler JS: Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol; 2010 Jan;20(1):58-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this review of glioma, ependymoma, and medulloblastoma, we highlight the differences between adults and children, including the higher incidence of spinal cord ependymoma and supratentorial high-grade glioma in the adult and a higher incidence of medulloblastoma in the child.
  • An effort is underway to better characterize adult and pediatric brain tumors biologically with an emphasis on improving our understanding of tumor genesis, malignant transformation, and some of the similarities and differences between tumor types and their response to conventional therapy.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Child. Child, Preschool. Combined Modality Therapy / methods. Disease Progression. Ependymoma / epidemiology. Ependymoma / therapy. Humans. Incidence. Infant. Infant, Newborn. Medulloblastoma / epidemiology. Medulloblastoma / therapy. Radiation Injuries. Young Adult

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  • (PMID = 19959032.001).
  • [ISSN] 1532-9461
  • [Journal-full-title] Seminars in radiation oncology
  • [ISO-abbreviation] Semin Radiat Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
  • [Other-IDs] NLM/ NIHMS425593; NLM/ PMC3529408
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81. Nakamura M, Ishii K, Watanabe K, Tsuji T, Matsumoto M, Toyama Y, Chiba K: Long-term surgical outcomes for myxopapillary ependymomas of the cauda equina. Spine (Phila Pa 1976); 2009 Oct 1;34(21):E756-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY OF BACKGROUND DATA: Some patients with myxopapillary ependymoma develop cerebrospinal fluid (CSF) dissemination leading to poor prognosis.
  • RESULTS: In 15 patients, total resection achieved (6 cases of en bloc resection without postoperative radiation, and in 9 cases piecemeal resection) was followed by whole brain and spinal cord radiation or local irradiation.
  • Of these, 2 patients who received radiation (24 Gy) only to the whole brain and spinal cord developed recurrence, and 2 who received whole brain and spinal cord radiation (24 Gy) supplemented with local radiation (46 Gy) developed no recurrence.
  • CONCLUSION: The results of the present study indicate that the surgical margin obtained at the initial surgery and the extent and amount of postoperative radiation can be crucial factors determining the prognosis of patients with myxopapillary ependymoma.
  • [MeSH-major] Cauda Equina. Ependymoma / surgery. Neurosurgical Procedures. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Incidence. Longitudinal Studies. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Prognosis. Radiotherapy, Adjuvant / methods. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19934795.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Rushing EJ, Cooper PB, Quezado M, Begnami M, Crespo A, Smirniotopoulos JG, Ecklund J, Olsen C, Santi M: Subependymoma revisited: clinicopathological evaluation of 83 cases. J Neurooncol; 2007 Dec;85(3):297-305
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumors arose in the posterior fossa (n = 43), lateral ventricles (n = 37), spinal cord (2) and only one arose in the temporal horn.
  • The most common mixture (13/15) was subependymoma and ependymoma.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Ependymoma / pathology. Glioma, Subependymal / pathology. Infratentorial Neoplasms / pathology. Mixed Tumor, Malignant / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Cohort Studies. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / pathology. Infant. Lateral Ventricles / pathology. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17569000.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Terezakis SA, Lovelock DM, Bilsky MH, Hunt MA, Zatcky J, Yamada Y: Image-guided intensity-modulated photon radiotherapy using multifractionated regimen to paraspinal chordomas and rare sarcomas. Int J Radiat Oncol Biol Phys; 2007 Dec 1;69(5):1502-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Image-guided intensity-modulated radiotherapy enables delivery of high-dose radiation to tumors close to the spinal cord.
  • We report our experience with multifractionated regimens using image-guided intensity-modulated radiotherapy to treat gross paraspinal disease to doses beyond cord tolerance.
  • CONCLUSIONS: The dose to paraspinal tumors has traditionally been limited to respect cord tolerance.
  • [MeSH-major] Chordoma / radiotherapy. Ependymoma / radiotherapy. Photons / therapeutic use. Radiotherapy, Intensity-Modulated / methods. Sarcoma / radiotherapy. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Humans. Male. Middle Aged. Retrospective Studies. Spinal Cord

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  • (PMID = 17689028.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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84. Palm T, Figarella-Branger D, Chapon F, Lacroix C, Gray F, Scaravilli F, Ellison DW, Salmon I, Vikkula M, Godfraind C: Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesis. Cancer; 2009 Sep 1;115(17):3955-68
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  • BACKGROUND: Ependymomas derive from ependymal cells that cover the cerebral ventricles and the central canal of the spinal cord.
  • CONCLUSIONS: Taken together, the tumor localization-related gene sets mainly implicated in stem cell maintenance, renewal, and differentiation suggest the dysregulation of localized cancer stem cells during ependymoma development.
  • [MeSH-major] Brain Neoplasms / genetics. Brain Neoplasms / pathology. Ependymoma / genetics. Ependymoma / pathology. Gene Expression Profiling
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Transformation, Neoplastic. Child. Child, Preschool. Humans. Infant. Middle Aged

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  • (PMID = 19536879.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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85. Mangels KJ, Johnson MD, Weil RJ: 35-year-old woman with progressive bilateral leg weakness. Brain Pathol; 2006 Apr;16(2):183-4, 187

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  • MRI demonstrated a T4-5 intradural mass ventral to the spinal cord, with an enhancing dural tail, consistent with meningioma.
  • At surgery an intradural, extramedullary, firm, black neoplasm was encountered, which invaded the ventral dura and elevated and distorted the spinal cord.
  • IGMS occur in the spinal leptomeninges and intracranially in approximately equal proportions.
  • Once metastasis, including drop metastasis from pigmented medulloblastomas, have been excluded, the differential includes pigmented meningiomas and schwannomas (solitary or as part of Carney complex), as well as other pigmented CNS tumors such as ependymoma and pineoblastoma and systemic diseases such as lymphoma . . .
  • [MeSH-major] Meningioma / pathology. Paresis / etiology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Functional Laterality. Humans. Thoracic Vertebrae. Treatment Outcome

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  • (PMID = 16768759.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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86. Rajaram V, Gutmann DH, Prasad SK, Mansur DB, Perry A: Alterations of protein 4.1 family members in ependymomas: a study of 84 cases. Mod Pathol; 2005 Jul;18(7):991-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ependymomas are common pediatric and adult CNS malignancies with a wide biologic spectrum that is often hard to predict using classic prognostic variables.
  • The most common genetic alteration has been the loss of the Protein 4.1 family member, NF2, predominantly in spinal ependymomas.
  • These findings prompted us to study Protein 4.1 family members (NF2, 4.1B, 4.1R, 4.1G) in a larger cohort of 84 ependymomas (51 intracranial and 33 spinal; 11 WHO grade I, 43 grade II, 30 grade III).
  • Additionally, frozen tissue from nine ependymomas (four intracranial and five spinal) was obtained for Western blot analysis for merlin, 4.1B and 4.1R expression.
  • The majority of cases harbored one or more detectable genetic alterations, but we found that 4.1B gene deletions and 4.1R loss of expression were statistically more common in the pediatric vs adult, intracranial vs spinal, and grade III vs grade I/II subsets (P-values of 0.038 to <0.001).
  • [MeSH-major] Ependymoma / pathology. Membrane Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Proteins / analysis. Blood Proteins / genetics. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Child. Child, Preschool. Cohort Studies. Cytoskeletal Proteins / analysis. Cytoskeletal Proteins / genetics. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Microfilament Proteins. Microtubule-Associated Proteins / analysis. Microtubule-Associated Proteins / genetics. Middle Aged. Neurofibromin 2 / analysis. Neurofibromin 2 / genetics. Spinal Cord Neoplasms / genetics. Spinal Cord Neoplasms / metabolism. Spinal Cord Neoplasms / pathology. Tumor Suppressor Proteins / analysis. Tumor Suppressor Proteins / genetics

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  • (PMID = 15731777.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Cytoskeletal Proteins; 0 / EPB41L3 protein, human; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / Microtubule-Associated Proteins; 0 / Neurofibromin 2; 0 / Tumor Suppressor Proteins; 0 / erythrocyte membrane band 4.1 protein
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87. Salpietro FM, Alafaci C, Collufio D, Lucerna S, Adorno A, Raudino G, Pecora C: Five-level one-piece laminoplasty for extensive tumors of the lumbar spine. J Neurosurg Sci; 2008 Sep;52(3):75-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The authors describe the surgical method and results of nonexpansive one-piece multivel laminoplasty of the whole lumbar spine, for microsurgical resection of extensive spinal tumors.
  • This technique allows a very comfortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the spinal anatomy.
  • A spinal magnetic resonance imaging (MRI) documented an intradural tumor extending from L2 to S1.
  • The authors believe that multilevel laminoplasty rather than laminectomy is the technique of choice as a posterior procedure for extensive lumbar spinal tumors.
  • With this technique, it is possible to obtain a very confortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the normal spine.
  • [MeSH-major] Ependymoma / surgery. Laminectomy / methods. Lumbar Vertebrae / surgery. Reconstructive Surgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Dura Mater / anatomy & histology. Dura Mater / surgery. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications / prevention & control. Spinal Canal / anatomy & histology. Spinal Canal / surgery. Spinal Cord / pathology. Spinal Cord / surgery. Subarachnoid Space / anatomy & histology. Subarachnoid Space / surgery. Treatment Outcome. Young Adult

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  • (PMID = 18636051.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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88. Shem KL: Neuroarthropathy of the wrist in paraplegia: A case report. J Spinal Cord Med; 2006;29(4):436-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/OBJECTIVE: Neuroarthropathy, also known as Charcot joint, is most commonly seen in the spine and other weight-bearing joints in individuals with spinal cord injury (SCI).
  • METHODS: Case report of neuroarthropathy in the wrist of a 46-year-old man with a 30-year history of T4 paraplegia caused by ependymoma.
  • A magnetic resonance image of the spine showed spinal cord atrophy at the cervicothoracic junction.
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17044396.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1864861
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89. Lehman NL: Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumors. J Neuropathol Exp Neurol; 2008 Sep;67(9):900-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most occur in the posterior fossa or spinal cord.
  • The 3 cortical ependymal tumors show a spectrum of features ranging from conventional and clear-cell ependymoma-like patterns to more angiocentric glioma-like histology.

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  • (PMID = 18716554.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS045077; United States / NINDS NIH HHS / NS / NS045077-05; United States / NINDS NIH HHS / NS / K08 NS045077-05; United States / NINDS NIH HHS / NS / K08 NS45077
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS131630; NLM/ PMC2805172
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90. Christ G, Denninger D, Dohm OS, Weigel B, Hönes A, Paulsen F: Craniospinal radiotherapy in an advanced technique. Strahlenther Onkol; 2008 Oct;184(10):530-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Using an extended source-skin distance of 160 cm only one dorsal field is necessary to cover the whole spinal axis.
  • For visual verification of field matching an additional line laser was first adjusted to the caudal edge of one lateral light field and then checked against the light field of the spinal field under the table.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted / instrumentation. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Cerebellar Neoplasms / radiography. Cerebellar Neoplasms / radiotherapy. Child. Child, Preschool. Computer Simulation. Ependymoma / radiography. Ependymoma / radiotherapy. Female. Germinoma / radiography. Germinoma / radiotherapy. Humans. Lasers. Male. Medulloblastoma / radiography. Medulloblastoma / radiotherapy. Middle Aged. Neuroectodermal Tumors, Primitive / radiography. Neuroectodermal Tumors, Primitive / radiotherapy. Pineal Gland / radiation effects. Pineal Gland / radiography. Pinealoma / radiography. Pinealoma / radiotherapy. Radiation Injuries / etiology. Radiotherapy. Tomography, X-Ray Computed

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  • (PMID = 19016043.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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91. Shigematsu N, Shinmoto H, Ito N, Kunieda E, Takeda A, Ohashi T, Kawaguchi O, Kawata T, Ito H, Kuribayashi S, Kubo A: Successful pregnancy and normal delivery after whole craniospinal irradiation in two patients. Anticancer Res; 2005 Sep-Oct;25(5):3481-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The lower border of the spinal field in WCSI should be the caudal border of the thecal sac, i.e., S2-S4.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Fertility / radiation effects. Ovary / radiation effects. Radiation Protection / methods. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Ependymoma / radiotherapy. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Pregnancy. Pregnancy Outcome

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  • (PMID = 16101166.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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92. Gül S, Kalayci M, Edebali N, Yurdakan G, Açikgöz B: A multilevel thoracolumbar meningioma in a young woman. Acta Neurochir (Wien); 2008 Aug;150(8):843-4
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  • Spinal meningiomas of five or more vertebral segment long are very rare and also less common in younger patients.
  • Interestingly, magnetic resonance imaging of this patient might easily be confused with ependymoma.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Spinal Cord Compression / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Laminectomy. Lumbar Vertebrae / pathology. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Spinal Fusion. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery

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  • (PMID = 18548187.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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93. Quraishi NA, Wolinsky JP, Bydon A, Witham T, Gokaslan ZL: Giant destructive myxopapillary ependymomas of the sacrum. J Neurosurg Spine; 2010 Feb;12(2):154-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Ependymoma / surgery. Sacrum. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Laminectomy. Lumbar Vertebrae / radiography. Lumbar Vertebrae / surgery. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Osteolysis / etiology. Osteolysis / radiography. Osteolysis / surgery. Pelvis / radiography. Pelvis / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20121349.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Plans G, Brell M, Cabiol J, Villà S, Torres A, Acebes JJ: Intracranial retrograde dissemination in filum terminale myxopapillary ependymomas. Acta Neurochir (Wien); 2006 Mar;148(3):343-6; discussion 346
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Brain Neoplasms / secondary. Cauda Equina / pathology. Ependymoma / secondary. Meningeal Neoplasms / secondary. Neoplasm Metastasis / physiopathology. Spinal Cord Neoplasms / pathology. Subarachnoid Space / physiopathology
  • [MeSH-minor] Adult. Decompression, Surgical. Disease Progression. Headache / diagnosis. Headache / etiology. Headache / physiopathology. Humans. Hypothalamic Neoplasms / radiotherapy. Hypothalamic Neoplasms / secondary. Hypothalamus / pathology. Hypothalamus / physiopathology. Hypothalamus / surgery. Laminectomy. Low Back Pain / etiology. Low Back Pain / physiopathology. Low Back Pain / surgery. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Pituitary Gland, Posterior / pathology. Pituitary Gland, Posterior / physiopathology. Pituitary Gland, Posterior / surgery. Radiotherapy / methods. Third Ventricle / pathology. Third Ventricle / physiopathology. Third Ventricle / surgery. Treatment Outcome

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  • (PMID = 16362177.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 35
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95. Fukudome N, Ohno E, Mochizuki M, Eguchi H, Kojima H: Three-dimensional reconstructive analysis of intracytoplasmic lumina found in ependymomas. Rinsho Byori; 2009 Apr;57(4):345-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Cytoplasm / pathology. Cytoplasm / radiography. Ependymoma / diagnosis. Image Processing, Computer-Assisted / methods. Imaging, Three-Dimensional / methods. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Male. Microscopy, Electron. Tomography, X-Ray Computed

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  • (PMID = 19489436.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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96. Tseng HM, Kuo LT, Lien HC, Liu KL, Liu MT, Huang CY: Prolonged survival of a patient with cervical intramedullary glioblastoma multiforme treated with total resection, radiation therapy, and temozolomide. Anticancer Drugs; 2010 Nov;21(10):963-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MRI showed an intramedullary mass lesion in the C2-C6 level, which was considered to be an ependymoma or astrocytoma.
  • [MeSH-major] Cervical Vertebrae. Dacarbazine / analogs & derivatives. Glioblastoma. Neurosurgical Procedures. Radiotherapy. Spinal Cord Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / adverse effects. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Disease-Free Survival. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 20838208.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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97. Järvelä S, Nordfors K, Jansson M, Haapasalo J, Helén P, Paljärvi L, Kalimo H, Kinnula V, Soini Y, Haapasalo H: Decreased expression of antioxidant enzymes is associated with aggressive features in ependymomas. J Neurooncol; 2008 Dec;90(3):283-91
MedlinePlus Health Information. consumer health - Antioxidants.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MnSOD, GLCL-C and TrxR expressions were significantly higher in tumors located in the spinal cord compared to those in the brain (P = 0.044, 0.046 and 0.004, respectively).
  • [MeSH-major] Antioxidants / metabolism. Central Nervous System Neoplasms / metabolism. Ependymoma / metabolism. Oxidoreductases / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Chi-Square Distribution. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Retrospective Studies. Statistics, Nonparametric. Superoxide Dismutase. Survival Analysis. Thioredoxin-Disulfide Reductase. Thioredoxins. Young Adult

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  • (PMID = 18682894.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 52500-60-4 / Thioredoxins; EC 1.- / Oxidoreductases; EC 1.15.1.1 / Superoxide Dismutase; EC 1.8.1.9 / Thioredoxin-Disulfide Reductase
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98. Song KW, Shin SI, Lee JY, Kim GL, Hyun YS, Park DY: Surgical results of intradural extramedullary tumors. Clin Orthop Surg; 2009 Jun;1(2):74-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The histopathological results are as follows: 4 cases of a meningioma, 4 cases of a schwannoma, 2 cases of an epidermoid cyst, 1 case of an arachnoid cyst, and 1 case of an ependymoma.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Orthopedic Procedures / methods. Young Adult

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  • (PMID = 19885058.001).
  • [ISSN] 2005-4408
  • [Journal-full-title] Clinics in orthopedic surgery
  • [ISO-abbreviation] Clin Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2766757
  • [Keywords] NOTNLM ; Extramedullary / Intradural / Tumor
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99. Borkar SA, Satyarthee GD, Sharma BS: Conus ependymoma with holocord syringomyelia. Neurol India; 2009 May-Jun;57(3):353-4
Hazardous Substances Data Bank. GADOLINIUM, ELEMENTAL .

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  • [Title] Conus ependymoma with holocord syringomyelia.
  • [MeSH-major] Ependymoma / complications. Spinal Cord Neoplasms / complications. Syringomyelia / complications
  • [MeSH-minor] Adult. Gadolinium. Humans. Magnetic Resonance Imaging / methods. Male

  • Genetic Alliance. consumer health - Ependymoma.
  • Genetic Alliance. consumer health - Syringomyelia.
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  • (PMID = 19587487.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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100. Shimizu S, Utsuki S, Sato K, Oka H, Fujii K, Mii K: Photodynamic diagnosis in surgery for spinal ependymoma. Case illustration. J Neurosurg Spine; 2006 Oct;5(4):380
Genetic Alliance. consumer health - Ependymoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic diagnosis in surgery for spinal ependymoma. Case illustration.
  • [MeSH-major] Aminolevulinic Acid. Ependymoma / diagnosis. Ependymoma / surgery. Photosensitizing Agents. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Spectrometry, Fluorescence

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  • (PMID = 17048778.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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