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71. Wu WX, Yu SZ, Sun CY, Wang Q, Jin SM, An TL: [Detection of chromosomal imbalance in ependymoma by comparative genomic hybridization]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):148-52
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  • [Title] [Detection of chromosomal imbalance in ependymoma by comparative genomic hybridization].
  • Chromosomal +1q and +7p happened predominantly in intracranial EDMs with an averagely onset age of <or= 30 years, and +7 was only detected in spinal EDMs of patients over 30 years old, the differences were statistically significant (P < 0.05).
  • [MeSH-major] Brain Neoplasms / genetics. Chromosome Aberrations. Ependymoma / genetics. Spinal Cord Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Comparative Genomic Hybridization. DNA, Neoplasm / genetics. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19575847.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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72. Ulrich CT, Beck J, Seifert V, Marquardt G: Ependymoma of conus medullaris presenting as subarachnoid haemorrhage. Acta Neurochir (Wien); 2008 Feb;150(2):185-8
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  • [Title] Ependymoma of conus medullaris presenting as subarachnoid haemorrhage.
  • Subarachnoid haemorrhage (SAH) due to spinal ependymoma is very rare.
  • Lumbar puncture confirmed SAH but cerebral angiography was negative, and further diagnostic work-up revealed an ependymoma of the conus medullaris as the source of the haemorrhage.
  • Only 17 patients with spontaneous SAH due to a spinal ependymoma have been reported since 1958.
  • However, in cases of SAH and negative diagnostic findings for cerebral aneurysms or malformations, this aetiology should be considered and work-up of the spinal axis completed.
  • [MeSH-major] Ependymoma / complications. Ependymoma / diagnosis. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / diagnosis. Subarachnoid Hemorrhage / etiology
  • [MeSH-minor] Adult. Humans. Lumbar Vertebrae. Male

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  • (PMID = 18058061.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 17
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73. Rushing EJ, Cooper PB, Quezado M, Begnami M, Crespo A, Smirniotopoulos JG, Ecklund J, Olsen C, Santi M: Subependymoma revisited: clinicopathological evaluation of 83 cases. J Neurooncol; 2007 Dec;85(3):297-305
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  • Tumors arose in the posterior fossa (n = 43), lateral ventricles (n = 37), spinal cord (2) and only one arose in the temporal horn.
  • The most common mixture (13/15) was subependymoma and ependymoma.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Ependymoma / pathology. Glioma, Subependymal / pathology. Infratentorial Neoplasms / pathology. Mixed Tumor, Malignant / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Cohort Studies. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / pathology. Infant. Lateral Ventricles / pathology. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [ISSN] 0167-594X
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  • [ISO-abbreviation] J. Neurooncol.
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4. Morgan RJ, Synold T, Mamelak A, Lim D, Al-Kadhimi Z, Twardowski P, Leong L, Chow W, Margolin K, Shibata S, Somlo G, Yen Y, Frankel P, Doroshow JH: Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors. Cancer Chemother Pharmacol; 2010 Oct;66(5):927-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.
  • The tumors included glioblastoma (6), anaplastic astrocytoma (2), metastatic non-small cell (3), small cell lung (2), and one each with medulloblastoma, ependymoma, and metastatic breast or colon carcinoma.

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  • (PMID = 20107803.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA033572; United States / NCI NIH HHS / CA / P30 CA033572-26; United States / NCI NIH HHS / CA / CA 33572
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 094ZI81Y45 / Tamoxifen; 7M7YKX2N15 / Topotecan; BG3F62OND5 / Carboplatin
  • [Other-IDs] NLM/ NIHMS335377; NLM/ PMC3265324
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75. Shem KL: Neuroarthropathy of the wrist in paraplegia: A case report. J Spinal Cord Med; 2006;29(4):436-9
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  • BACKGROUND/OBJECTIVE: Neuroarthropathy, also known as Charcot joint, is most commonly seen in the spine and other weight-bearing joints in individuals with spinal cord injury (SCI).
  • METHODS: Case report of neuroarthropathy in the wrist of a 46-year-old man with a 30-year history of T4 paraplegia caused by ependymoma.
  • A magnetic resonance image of the spine showed spinal cord atrophy at the cervicothoracic junction.
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17044396.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1864861
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76. Shintaku M, Nagata N, Itoh H: Tanycytic ependymoma of the spinal cord with anaplastic cytological features. Brain Tumor Pathol; 2009;26(1):7-10
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  • [Title] Tanycytic ependymoma of the spinal cord with anaplastic cytological features.
  • In a 43-year-old man, an intramedullary spinal cord tumor spreading from the level of the T2 to T5 vertebrae was subtotally resected.
  • This is the first documentation of tanycytic ependymoma in which tumor cells showed anaplastic cytological features.
  • [MeSH-major] Ependymoma / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Anaplasia / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / immunology. Magnetic Resonance Imaging. Male


77. Palacio FJ, Fornet I, Morillas P, López MA, Reina MA, López A: [Continuous subarachnoid analgesia and anesthesia for labor and cesarean section in a patient who had previously undergone surgery for ependymoma]. Rev Esp Anestesiol Reanim; 2008 Jun-Jul;55(6):371-4
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  • [Title] [Continuous subarachnoid analgesia and anesthesia for labor and cesarean section in a patient who had previously undergone surgery for ependymoma].
  • We report the case of a 38-year-old primipara who had undergone surgery 2 years earlier for an intradural ependymoma at L2-L3 and who was currently asymptomatic.
  • Continuous subarachnoid anesthesia may be considered the technique of choice where the patient has a history of spinal surgery.
  • [MeSH-major] Analgesia, Obstetrical. Anesthesia, Obstetrical. Anesthesia, Spinal. Cesarean Section
  • [MeSH-minor] Adult. Ependymoma / surgery. Female. Humans. Pregnancy. Spinal Cord Neoplasms / surgery

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  • (PMID = 18693664.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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78. Volpp PB, Han K, Kagan AR, Tome M: Outcomes in treatment for intradural spinal cord ependymomas. Int J Radiat Oncol Biol Phys; 2007 Nov 15;69(4):1199-204
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes in treatment for intradural spinal cord ependymomas.
  • PURPOSE: Spinal cord ependymomas are rare tumors, accounting for <2% of all primary central nervous system tumors.
  • This study assessed the treatment outcomes for patients diagnosed with spinal cord ependymomas within the Southern California Kaiser Permanente system.
  • [MeSH-major] Ependymoma / radiotherapy. Ependymoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Radiotherapy, Adjuvant. Salvage Therapy / methods. Survival Rate. Treatment Outcome

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  • (PMID = 17689025.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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79. Idowu MO, Rosenblum MK, Wei XJ, Edgar MA, Soslow RA: Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. Am J Surg Pathol; 2008 May;32(5):710-8
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  • [Title] Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein.
  • The adult extra-axial cases demonstrated more architectural variability than the CNS cases.
  • We observed that both the CNS and adult extra-axial ependymomas expressed GFAP diffusely, whereas only 9 stage III, high-grade ovarian serous papillary carcinomas stained with GFAP (2 strongly and diffusely and 7 exhibiting focally weak expression).
  • There were significant immunophenotypic differences between adult extra-axial and CNS ependymomas, with extra-axial cases preferentially expressing 34betaE12 (60% vs. 0%), CK18 (100% vs. 20%), CAM 5.2 (60% vs. 10%), CK7 (80% vs. 10%), ER (100% vs. 10%), and PR (80% vs. 20%).
  • Two spinal cord ependymomas expressed CK18, 1 expressed CK7, and 1 expressed CAM 5.2.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Central Nervous System Neoplasms / metabolism. Ependymoma / metabolism. Glial Fibrillary Acidic Protein / metabolism. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Immunoenzyme Techniques. Infant. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging

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  • (PMID = 18360284.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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80. Andrade FG, de Aguiar PH, Matushita H, Taricco MA, Oba-Shinjo SM, Marie SK, Teixeira MJ: Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo. Arq Neuropsiquiatr; 2009 Sep;67(3A):626-32
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  • [Title] Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo.
  • METHOD: Data of clinical presentation, tumor location, duration of symptoms, degree of resection and complementary treatment of 34 patients with intracranial ependymoma and 31 with intramedullary ependymoma who underwent surgery in the last ten years were collected and correlated with the recurrence time and overall survival.
  • Data analyses of intramedullary ependymoma did not show correlation with overall survival and likelihood of recurrence.
  • [MeSH-major] Brain Neoplasms / surgery. Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Disease-Free Survival. Female. Hospitals, University. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult


81. Shimizu S, Utsuki S, Sato K, Oka H, Fujii K, Mii K: Photodynamic diagnosis in surgery for spinal ependymoma. Case illustration. J Neurosurg Spine; 2006 Oct;5(4):380
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic diagnosis in surgery for spinal ependymoma. Case illustration.
  • [MeSH-major] Aminolevulinic Acid. Ependymoma / diagnosis. Ependymoma / surgery. Photosensitizing Agents. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Spectrometry, Fluorescence

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  • (PMID = 17048778.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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82. Cosnard G, Duprez T, Grandin C, Hernalsteen D: [Intramedullary tumours and pseudotumours]. J Radiol; 2010 Sep;91(9 Pt 2):988-97
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  • Swelling of the spinal cord and/or enhancement after intravenous gadolinium administration are not always specific features of intramedullary tumour.
  • A tumour is characterized by its sagittal location, axial topography: central, lateral or exophytic, its size and size of the spinal canal, macroscopic components: calcium, fat, methemoglobin, melanin, hemosiderin, vascular pedicle, cystic component, enhancement after intravenous gadolinium administration, effect on the spinal cord tracts and edema.
  • Characteristics: astrocytoma is lateral and infiltrative, ependymoma is central with white matter tract displacement and hemosiderin cap, hemangioblastoma is postero-lateral and shows enhancement with a vascular pedicle, metastases are very edematous or leptomeningeal in location.
  • [MeSH-major] Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Spinal Cord Diseases / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Astrocytoma / diagnosis. Contrast Media / administration & dosage. Diagnosis, Differential. Ependymoma / diagnosis. Female. Hemangioblastoma / diagnosis. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / etiology. Humans. Lymphoma / diagnosis. Myelitis / diagnosis. Myelitis / etiology. Sensitivity and Specificity

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  • (PMID = 20814390.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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83. Timothy J, Hanna SJ, Furtado N, Shanmuganathan M, Tyagi A: The use of titanium non-penetrating clips to close the spinal dura. Br J Neurosurg; 2007 Jun;21(3):268-71
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  • [Title] The use of titanium non-penetrating clips to close the spinal dura.
  • We present the results of our initial experience in the use of non-penetrating titanium clips in the closure of spinal dura.
  • The commonest diagnoses were meningioma, ependymoma and neurofibroma.
  • Our early experience with the use of non-penetrating clips for the closure of the spinal dura is presented.
  • [MeSH-major] Dura Mater / surgery. Postoperative Complications / prevention & control. Spinal Cord / surgery. Surgical Instruments
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Subdural Effusion / etiology. Titanium. Treatment Outcome

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  • (PMID = 17612916.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] D1JT611TNE / Titanium
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84. Song KW, Shin SI, Lee JY, Kim GL, Hyun YS, Park DY: Surgical results of intradural extramedullary tumors. Clin Orthop Surg; 2009 Jun;1(2):74-80
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  • RESULTS: The histopathological results are as follows: 4 cases of a meningioma, 4 cases of a schwannoma, 2 cases of an epidermoid cyst, 1 case of an arachnoid cyst, and 1 case of an ependymoma.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Orthopedic Procedures / methods. Young Adult

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  • [Cites] Surg Neurol. 1999 Dec;52(6):552-62 [10660020.001]
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  • (PMID = 19885058.001).
  • [ISSN] 2005-4408
  • [Journal-full-title] Clinics in orthopedic surgery
  • [ISO-abbreviation] Clin Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2766757
  • [Keywords] NOTNLM ; Extramedullary / Intradural / Tumor
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85. Gül S, Kalayci M, Edebali N, Yurdakan G, Açikgöz B: A multilevel thoracolumbar meningioma in a young woman. Acta Neurochir (Wien); 2008 Aug;150(8):843-4
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  • Spinal meningiomas of five or more vertebral segment long are very rare and also less common in younger patients.
  • Interestingly, magnetic resonance imaging of this patient might easily be confused with ependymoma.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Spinal Cord Compression / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Laminectomy. Lumbar Vertebrae / pathology. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Spinal Fusion. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery

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  • (PMID = 18548187.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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86. Mobley B, Kalani MY, Harsh GR 4th, Edwards MS, Vogel H: Papillary tumor of the spinal cord: report of 2 cases. Am J Surg Pathol; 2009 Aug;33(8):1191-7
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  • [Title] Papillary tumor of the spinal cord: report of 2 cases.
  • Intramedullary spinal cord tumors constitute a small fraction of central nervous system tumors in the pediatric population; of these, the majority are ependymomas or astrocytomas.
  • We report 2 pediatric spinal cord tumor cases with unique morphologic and immunohistochemical features.
  • The clinical features, including propensity for recurrence and remote subarachnoid spread, and the pathologic features of these tumors are reminiscent of papillary tumor of the pineal region, ependymoma, and choroid plexus papilloma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Male. Neurosurgical Procedures. Radiotherapy

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  • (PMID = 19417584.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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87. Sakai Y, Matsuyama Y, Katayama Y, Imagama S, Ito Z, Wakao N, Kanemura T, Yoshida G, Sato K, Ando T, Nakamura H, Kato F, Yukawa Y, Ito K, Ishiguro N: Spinal myxopapillary ependymoma: neurological deterioration in patients treated with surgery. Spine (Phila Pa 1976); 2009 Jul 1;34(15):1619-24
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  • [Title] Spinal myxopapillary ependymoma: neurological deterioration in patients treated with surgery.
  • OBJECTIVE.: To evaluate the postoperative outcomes of patients surgically treated for spinal myxopapillary ependymoma.
  • The heterogeneously enhanced ependymoma not only should be evaluated and treated meticulously, but also surgeons should not stick to total removal in infiltrated and adhering tumors as subtotally resected tumors with postoperative radiotherapy have not always recurred.
  • [MeSH-major] Ependymoma / surgery. Neurosurgical Procedures / adverse effects. Postoperative Complications / etiology. Spinal Cord / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Disease Progression. Female. Humans. Iatrogenic Disease / prevention & control. Magnetic Resonance Imaging. Male. Middle Aged. Polyradiculopathy / etiology. Polyradiculopathy / physiopathology. Polyradiculopathy / prevention & control. Spinal Cord Compression / etiology. Spinal Cord Compression / physiopathology. Spinal Cord Compression / prevention & control. Urinary Bladder, Neurogenic / etiology. Urinary Bladder, Neurogenic / physiopathology. Urinary Bladder, Neurogenic / prevention & control


88. Adamson DC, Cummings TJ, Friedman AH: Myxopapillary ependymoma and fatty filum in an adult with tethered cord syndrome: a shared embryological lesion? Case report. Neurosurgery; 2005 Aug;57(2):E373; discussion E373
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  • [Title] Myxopapillary ependymoma and fatty filum in an adult with tethered cord syndrome: a shared embryological lesion? Case report.
  • OBJECTIVE AND IMPORTANCE: Myxopapillary ependymoma and fatty fila are traditionally thought to arise via completely different pathophysiologies.
  • CLINICAL PRESENTATION: A 28-year-old woman presented with low back pain, bilateral leg radiculopathies, and mild leg weakness suggestive of tethered cord syndrome.
  • Magnetic resonance imaging revealed lesions in the area of the conus medullaris consistent with a myxopapillary ependymoma and fatty filum.
  • CONCLUSION: We report an unusual case of a myxopapillary ependymoma coexisting with a fatty filum in an adult patient.
  • [MeSH-major] Cauda Equina / pathology. Ependymoma / complications. Lipoma / complications. Neural Tube Defects / complications. Spinal Cord Neoplasms / complications


89. Ma YT, Ramachandra P, Spooner D: Case report: primary subcutaneous sacrococcygeal ependymoma: a case report and review of the literature. Br J Radiol; 2006 May;79(941):445-7
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  • [Title] Case report: primary subcutaneous sacrococcygeal ependymoma: a case report and review of the literature.
  • We report a 37-year-old woman with a subcutaneous sacrococcygeal ependymoma with iliac lymph nodal metastasis at presentation.
  • [MeSH-major] Ependymoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers / analysis. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Ilium. Immunohistochemistry / methods. Lymphatic Metastasis. Magnetic Resonance Imaging. Radiotherapy, Adjuvant. Reoperation. S100 Proteins / analysis. Sacrococcygeal Region. Vimentin / analysis

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  • (PMID = 16632628.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 12
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90. Salpietro FM, Alafaci C, Collufio D, Lucerna S, Adorno A, Raudino G, Pecora C: Five-level one-piece laminoplasty for extensive tumors of the lumbar spine. J Neurosurg Sci; 2008 Sep;52(3):75-8
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  • The authors describe the surgical method and results of nonexpansive one-piece multivel laminoplasty of the whole lumbar spine, for microsurgical resection of extensive spinal tumors.
  • This technique allows a very comfortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the spinal anatomy.
  • A spinal magnetic resonance imaging (MRI) documented an intradural tumor extending from L2 to S1.
  • The authors believe that multilevel laminoplasty rather than laminectomy is the technique of choice as a posterior procedure for extensive lumbar spinal tumors.
  • With this technique, it is possible to obtain a very confortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the normal spine.
  • [MeSH-major] Ependymoma / surgery. Laminectomy / methods. Lumbar Vertebrae / surgery. Reconstructive Surgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Dura Mater / anatomy & histology. Dura Mater / surgery. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications / prevention & control. Spinal Canal / anatomy & histology. Spinal Canal / surgery. Spinal Cord / pathology. Spinal Cord / surgery. Subarachnoid Space / anatomy & histology. Subarachnoid Space / surgery. Treatment Outcome. Young Adult

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  • (PMID = 18636051.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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91. Azarpira N, Rakei M, Mokhtari M: Cytologic findings in malignant ependymoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):1023-6
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  • [Title] Cytologic findings in malignant ependymoma: a case report.
  • Ependymomas are uncommon glial neoplasms of the CNS, arising from ependymal lining of the ventricular system and central canal of the spinal cord.
  • Anaplastic ependymoma is a rare tumor that causes diagnostic difficulties in imprint cytology because of variable cytomorphologic findings.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Ependymoma / pathology
  • [MeSH-minor] Cell Aggregation. Fatal Outcome. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Rosette Formation. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 21053591.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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92. Shrivastava RK, Epstein FJ, Perin NI, Post KD, Jallo GI: Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis. J Neurosurg Spine; 2005 Mar;2(3):249-55
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  • [Title] Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis.
  • OBJECT: Intramedullary spinal cord tumors (IMSCTs) in the older-age adult population pose complex management issues regarding the extent of resection and functional outcome, especially in terms of quality of life.
  • Historically, IMSCTs in the older adult population were treated with irradiation alone because it was assumed that functional recovery would be poor.
  • Ependymoma was the most common tumor (83%), and 55% were located in the thoracic spine.
  • The longer prodromal period in the older adult population may reflect the fact that their diagnosis and workup is inadequate.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 15796348.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Sun JJ, Wang ZY, Xie JC, Li ZD, Ma CC, Liu B, Zhao JZ: [Comparative analysis between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas]. Beijing Da Xue Xue Bao; 2010 Apr 18;42(2):183-7
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  • [Title] [Comparative analysis between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas].
  • OBJECTIVE: To comparatively analyze the different and common points between multi-segments intramedullary spinal cord congenital tumors and benign ependymomas, such as the patient's age, gender, nervous functions and tumor location, longitudinal extension, and removed extent.
  • METHODS: Data were studied from 12 patients with multi-segments intramedullary spinal cord congenital tumors and 19 patients with multi-segments intramedullary spinal cord benign ependymomas who underwent microsurgery for the tumor using a posterior approach.
  • Those located at the conus accounted for almost 83.3% (10/12) multi-segments intramedullary spinal cord congenital tumors.
  • Because of the stiff adhesion with adjacent neural structures or penetrative growth in surrounding spinal marrow, some congenital tumors could not totally removed by force.
  • 78.9 (15/19) percent of multi-segments intramedullary spinal cord benign ependymomas were located at the cervical and cervicothoracic segments.
  • CONCLUSION: It is known from the clinical files that most multi-segments intramedullary spinal cord congenital tumors are found in young patients and most benign ependymomas in the middle-aged.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / congenital. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Microsurgery / methods. Neurosurgical Procedures / methods. Teratoma / congenital. Teratoma / diagnosis. Teratoma / surgery. Young Adult

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  • (PMID = 20396361.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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94. Jacob A, Das K, Boggild M, Buxton N: Inflammation or neoplasm? Another side to the story. Clin Neurol Neurosurg; 2006 Dec;108(8):811-2
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  • [MeSH-major] Ependymoma / diagnosis. Myelitis, Transverse / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnostic Errors. Humans. Magnetic Resonance Imaging. Male. Methylprednisolone / administration & dosage. Oligoclonal Bands / cerebrospinal fluid. Spinal Cord / pathology. Treatment Outcome

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  • [CommentOn] Clin Neurol Neurosurg. 2006 Mar;108(3):284-9 [16376015.001]
  • (PMID = 16793201.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Oligoclonal Bands; X4W7ZR7023 / Methylprednisolone
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95. Szpak GM, Lewandowska E, Schmidt-Sidor B, Pasennik E, Modzelewska J, Stepień T, Zdaniuk G, Kulczycki J, Wierzba-Bobrowicz T: Giant cell ependymoma of the spinal cord and fourth ventricle coexisting with syringomyelia. Folia Neuropathol; 2008;46(3):220-31
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  • [Title] Giant cell ependymoma of the spinal cord and fourth ventricle coexisting with syringomyelia.
  • This report presents a case of widespread intramedullary giant cell ependymoma arising from the central canal of the C4 segment of the spinal cord in a 28-year-old man admitted to hospital with tetraplegia and signs of increased intracranial pressure, eight months after surgical spinal cervical decompression without tetraplegia improvement.
  • Magnetic resonance imaging and autopsy revealed a tumour extending from segment C3/C4 of the spinal cord to the lower half of the fourth ventricle with coexisting syringomyelia.
  • This slow-growing ependymoma of low-grade malignancy exhibited unusual morphology as well as degenerative and ischaemic changes.
  • The morphological diagnostic criteria of unusual giant-cell variant of ependymoma and tumour-related syringomyelia in adults are discussed, based on the presented case and a review of the literature.


96. Bagley CA, Wilson S, Kothbauer KF, Bookland MJ, Epstein F, Jallo GI: Long term outcomes following surgical resection of myxopapillary ependymomas. Neurosurg Rev; 2009 Jul;32(3):321-34; discussion 334
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  • Myxopapillary ependymomas, a specific tumor variant of spinal cord ependymomas, occur most commonly in the lumbosacral region.
  • During the study period, 1,013 patients underwent surgery for spinal cord tumors.
  • Fifty-two of the patients had a myxopapillary ependymoma.
  • Fourteen pediatric patients were diagnosed with myxopapillary ependymoma.
  • The adult mean age was 38.7 years.
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Arthritis, Experimental / etiology. Arthritis, Experimental / pathology. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Postoperative Complications / epidemiology. Postoperative Complications / pathology. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19221818.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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97. Gallia GL, Burger PC, Suk I, Bagley CA, Wolinsky JP, Garonzik IM, Gokaslan ZL: Concomitant conus medullaris ependymoma and filum terminale lipoma: case report. Neurosurgery; 2006 Jun;58(6):E1214; discussion E1214
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concomitant conus medullaris ependymoma and filum terminale lipoma: case report.
  • In this report, we describe the clinical presentation, radiographic findings, operative details, and pathological features of a patient with a conus medullaris ependymoma and a filum terminale lipoma.
  • Histopathological examination demonstrated a conus medullaris ependymoma and filum terminale lipoma.
  • CONCLUSION: Spinal cord ependymomas are almost exclusively single lesions and their coexistence with other pathological entities is rare.
  • In this report, we describe a patient with a concomitant conus medullaris ependymoma and filum terminale lipoma.
  • [MeSH-major] Cauda Equina / surgery. Ependymoma / surgery. Lipoma / surgery. Lumbar Vertebrae / surgery. Neoplasms, Multiple Primary / surgery. Peripheral Nervous System Neoplasms / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Laminectomy. Magnetic Resonance Imaging

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  • (PMID = 16723873.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Tredway TL, Santiago P, Hrubes MR, Song JK, Christie SD, Fessler RG: Minimally invasive resection of intradural-extramedullary spinal neoplasms. Neurosurgery; 2006 Feb;58(1 Suppl):ONS52-8; discussion ONS52-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive resection of intradural-extramedullary spinal neoplasms.
  • OBJECTIVE: Spinal intradural-extramedullary neoplasms are uncommon lesions that usually cause pain or neurological deficit secondary to neural compression.
  • Histologically, five tumors were determined to be schwannomas and one was identified as a myxopapillary ependymoma.
  • [MeSH-major] Ependymoma / surgery. Minimally Invasive Surgical Procedures / methods. Spinal Cord Neoplasms / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Laminectomy / methods. Magnetic Resonance Imaging / methods. Male. Middle Aged. Treatment Outcome

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  • [CommentIn] Neurosurgery. 2006 Nov;59(5):E1152 [17143217.001]
  • (PMID = 16479629.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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99. Terezakis SA, Lovelock DM, Bilsky MH, Hunt MA, Zatcky J, Yamada Y: Image-guided intensity-modulated photon radiotherapy using multifractionated regimen to paraspinal chordomas and rare sarcomas. Int J Radiat Oncol Biol Phys; 2007 Dec 1;69(5):1502-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Image-guided intensity-modulated radiotherapy enables delivery of high-dose radiation to tumors close to the spinal cord.
  • We report our experience with multifractionated regimens using image-guided intensity-modulated radiotherapy to treat gross paraspinal disease to doses beyond cord tolerance.
  • CONCLUSIONS: The dose to paraspinal tumors has traditionally been limited to respect cord tolerance.
  • [MeSH-major] Chordoma / radiotherapy. Ependymoma / radiotherapy. Photons / therapeutic use. Radiotherapy, Intensity-Modulated / methods. Sarcoma / radiotherapy. Spinal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Humans. Male. Middle Aged. Retrospective Studies. Spinal Cord

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  • (PMID = 17689028.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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100. Gormley KM, Gutowski NJ: Recurrent headache and sixth nerve palsy associated with lumbar ependymoma. J Neurol; 2005 Mar;252(3):359-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent headache and sixth nerve palsy associated with lumbar ependymoma.
  • [MeSH-major] Abducens Nerve Diseases / complications. Ependymoma / complications. Headache / etiology. Spinal Cord Neoplasms / complications
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male

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