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1. Kim DH, Cho JH, Lee SH, Kim HK, Bang SM, Song SY, Chung JB, Park SW: [Two cases of pancreatic ductal adenocarcinoma, manifested as solid pseudopapillary tumor and intraductal papillary mucinous neoplasm]. Korean J Gastroenterol; 2008 Feb;51(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two cases of pancreatic ductal adenocarcinoma, manifested as solid pseudopapillary tumor and intraductal papillary mucinous neoplasm].
  • Whereas cystic neoplasm of the pancreas is a rare type of pancreatic tumor, surgical resection provides good prognosis because of its low possibility of local invasion or distant metastasis.
  • In case of pancreatic cystic tumor, radiologic differentiation between benign and malignant lesions is crucial for the selection of appropriate treatment and the prediction of prognosis.
  • And ductal adenocarcinoma of pancreas presenting in cystic form is an uncommon type of cystic tumor, making it extremely rare among all pancreatic malignancies.
  • We report two cases of atypical pancreatic ductal adenocarcinoma presenting as solid pseudopapillary tumor and intraductal papillary mucinous neoplasm, respectively.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Pancreatectomy. Tomography, X-Ray Computed

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  • (PMID = 18349578.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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2. Liu BA, Li ZM, Su ZS, She XL: Pathological differential diagnosis of solid-pseudopapillary neoplasm and endocrine tumors of the pancreas. World J Gastroenterol; 2010 Feb 28;16(8):1025-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological differential diagnosis of solid-pseudopapillary neoplasm and endocrine tumors of the pancreas.
  • AIM: To investigate differential points of solid-pseudopapillary neoplasm (SPN) of the pancreas and pancreatic endocrine tumor (PET).
  • The mean diameter of the tumors was 11.0 cm, 9/10 cases were cystic or a mixture of solid and cystic structures, and there was hemorrhage and necrosis on the cut surface in 8/10 (80%) cases.
  • The mean size of the tumors was 2.9 cm, most of the tumors were solid, only 3/14 (21%) were a mixture of solid and cystic structures, and macroscopic hemorrhage and necrosis were much less common (3/14, 21%).
  • Histologically, tumor cells were arranged in trabecular, acinar or solid patterns and demonstrated no pseudopapillary structure and discohesive appearance in all 14 (100%) cases.
  • [MeSH-minor] Adolescent. Adult. Base Sequence. Cadherins / genetics. Cadherins / metabolism. DNA Mutational Analysis. Female. Humans. Male. Middle Aged. Molecular Sequence Data. Mutation. Pancreas / anatomy & histology. Pancreas / metabolism. Pancreas / pathology. Retrospective Studies. Young Adult. beta Catenin / genetics. beta Catenin / metabolism

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  • (PMID = 20180245.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
  • [Other-IDs] NLM/ PMC2828590
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3. Hav M, Lem D, Chhut SV, Kong R, Pauwels P, Cuvelier C, Piet P: Clear-cell variant of solid-pseudopapillary neoplasm of the pancreas: a case report and review of the literature. Malays J Pathol; 2009 Dec;31(2):137-41
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  • [Title] Clear-cell variant of solid-pseudopapillary neoplasm of the pancreas: a case report and review of the literature.
  • Solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm reported to have a favourable prognosis because of its slow-growing behaviour.
  • Microscopically, the tumour showed an extensive solid growth pattern consisting of cells with abundant clear cytoplasm, and papillary areas containing cells with eosinophilic cytoplasm, indicating a clear-cell solid-papillary neoplasm.
  • Difficulties are recognized in differentiating clear-cell SPN from "sugar" tumours, metastatic renal cell carcinoma, clear-cell variant of pancreatic endocrine neoplasm and ductal adenocarcinoma.
  • Although a rare neoplasm, it is important to recognize this entity for appropriate management.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carcinoma, Islet Cell / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Cell Nucleus / chemistry. Cell Nucleus / pathology. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Perivascular Epithelioid Cell Neoplasms / diagnosis


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4. Foltys D, Moench C, Burck I, Hoppe-Lotichius M, Schad A, Teufel A, Heise M, Otto G: [The solid pseudopapillary tumor (SPT)--a rare neoplasm of the pancreas]. Z Gastroenterol; 2008 Jul;46(7):689-94
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  • [Title] [The solid pseudopapillary tumor (SPT)--a rare neoplasm of the pancreas].
  • [Transliterated title] Der solid pseudopapilläre Pankreastumor (SPT)--eine seltene Raumforderung der Bauchspeicheldrüse.
  • In exceptional cases the tumour presents as solid pseudopapillary carcinoma (SPC) with typical malignant features and even metastases.
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 18618380.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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5. Tognarini I, Tonelli F, Nesi G, Martineti V, Galli G, Gozzini A, Colli E, Zonefrati R, Paglierani M, Marini F, Sorace S, Cavalli T, Cavalli L, Tanini A, Brandi ML: In vitro effects of oestrogens, antioestrogens and SERMs on pancreatic solid pseudopapillary neoplasm-derived primary cell culture. Cell Oncol; 2010;32(5-6):331-43
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  • [Title] In vitro effects of oestrogens, antioestrogens and SERMs on pancreatic solid pseudopapillary neoplasm-derived primary cell culture.
  • BACKGROUND: Solid-pseudopapillary neoplasms of the pancreas (SPNs) are uncommon tumours usually frequent in young women.
  • Expression of ERalpha, ERbeta and progesterone mRNAs was demonstrated in SPNC and tumor tissue.
  • [MeSH-minor] Adult. Antineoplastic Agents, Hormonal / pharmacology. Antineoplastic Agents, Hormonal / therapeutic use. Cell Culture Techniques. Cell Line, Tumor. Cell Proliferation / drug effects. Female. Humans

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  • (PMID = 20364070.001).
  • [ISSN] 1875-8606
  • [Journal-full-title] Cellular oncology : the official journal of the International Society for Cellular Oncology
  • [ISO-abbreviation] Cell. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Estrogen Receptor Modulators; 0 / Estrogens; 0 / Receptors, Estrogen; 0 / Selective Estrogen Receptor Modulators; 094ZI81Y45 / Tamoxifen; 22X328QOC4 / fulvestrant; 4TI98Z838E / Estradiol
  • [Other-IDs] NLM/ PMC4619239
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6. Schönleben F, Qiu W, Ciau NT, Ho DJ, Li X, Allendorf JD, Remotti HE, Su GH: PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res; 2006 Jun 15;12(12):3851-5
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  • [Title] PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas.
  • PURPOSE: Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic-alpha (PIK3CA) gene in various human solid tumors.
  • The mutational status of PIK3CA in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) has not been evaluated previously.

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  • (PMID = 16778113.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K01 CA095434; United States / NCI NIH HHS / CA / R01 CA109525; United States / NCI NIH HHS / CA / CA95434
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human
  • [Other-IDs] NLM/ NIHMS11634; NLM/ PMC1780026
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7. Ahmad Z, Yaqoob N, Muzaffar S, Ahmad N: Solid and cystic epithelial neoplasm of pancreas with metastasis: report of a highly unusual case. J Pak Med Assoc; 2005 Jan;55(1):37-9
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  • [Title] Solid and cystic epithelial neoplasm of pancreas with metastasis: report of a highly unusual case.
  • Solid and cystic papillary epithelial neoplasms of the pancreas are uncommon tumors occurring predominantly in young women.
  • [MeSH-minor] Adult. Female. Humans. Omentum. Tomography, X-Ray Computed

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  • [ErratumIn] J Pak Med Assoc. 2005 Jun;55(6):268. Yaqboob, Nausheed [corrected to Yaqoob, Nausheen]
  • (PMID = 15816695.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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8. Hajdú N, Belágyi T, Gyurus P, Oláh A: [Solid pseudopapillary neoplasm of the pancreas]. Magy Seb; 2008 Apr;61(2):65-70
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  • [Title] [Solid pseudopapillary neoplasm of the pancreas].
  • [Transliterated title] A pancreas solid pseudopapillaris tumora.
  • Solid pseudopapillary neoplasms (SPN) of the pancreas are rare tumours with low malignant potential, usually affecting young women.
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Immunohistochemistry. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18426709.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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9. Tipton SG, Smyrk TC, Sarr MG, Thompson GB: Malignant potential of solid pseudopapillary neoplasm of the pancreas. Br J Surg; 2006 Jun;93(6):733-7
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  • [Title] Malignant potential of solid pseudopapillary neoplasm of the pancreas.
  • BACKGROUND: Solid pseudopapillary neoplasms of the pancreas are rare malignant lesions of the pancreas that typically occur in young women.
  • Solid pseudopapillary neoplasm was suspected in only half of these patients before operation.
  • On computed tomography, ultrasonography and/or magnetic resonance imaging, three lesions were solid, three were largely cystic, and five had solid and cystic components.
  • CONCLUSION: Solid pseudopapillary neoplasm of the pancreas should be considered in the differential diagnosis of any solid or partly cystic pancreatic mass in women aged less than 35 years.
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pancreatectomy / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright (c) 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 16609955.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Kang CM, Kim HG, Kim KS, Choi JS, Lee WJ, Kim BR: Laparoscopic distal pancreatectomy for solid pseudopapillary neoplasm of the pancreas-report of two cases. Hepatogastroenterology; 2007 Jun;54(76):1053-6
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  • [Title] Laparoscopic distal pancreatectomy for solid pseudopapillary neoplasm of the pancreas-report of two cases.
  • Solid pseudopapillary neoplasm of the pancreas is a rare pathologic entity.
  • We present two cases of laparoscopic distal pancreatectomy in female patients of incidentally found pancreatic solid pseudopapapillary neoplasm, with review of disease and technical aspect.
  • This minimal invasive surgery can be safely applied to benign or low-grade malignant tumor of the pancreas especially in young and female patients.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Splenectomy. Treatment Outcome

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  • (PMID = 17629037.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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11. Lee SE, Jang JY, Hwang DW, Park KW, Kim SW: Clinical features and outcome of solid pseudopapillary neoplasm: differences between adults and children. Arch Surg; 2008 Dec;143(12):1218-21
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  • [Title] Clinical features and outcome of solid pseudopapillary neoplasm: differences between adults and children.
  • OBJECTIVES: To delineate the clinical and pathological characteristics of solid pseudopapillary neoplasm (SPN), compare them between adults and children, and determine the predictive features suggesting malignant potential.
  • The mean tumor size in children was significantly larger than in adults (8.0 vs 6.0 cm; P < .03).
  • In children, the tumor was located in the head of the pancreas (10 of 15; 66.7%) and in adults, in the body or tail (38 of 47; 80.9%) (P = .001).
  • Two patients had a tumor recurrence.
  • There were no tumor-related deaths.
  • CONCLUSION: Solid pseudopapillary neoplasm had different clinical features in adults and children.
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 19075175.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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12. Xing BC, Sun Y, Bao Q, Qian HG, Hao CY, Huang XF, Wang Y, Gu J, Ji JF: [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm]. Zhonghua Yi Xue Za Zhi; 2006 Mar 14;86(10):690-2
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  • [Title] [Spleen-preserving distal pancreatectomy in treatment of solid-pseudopapillary neoplasm].
  • METHODS: Four patients with solid-pseudopapillary neoplasm, 1 males and 3 females, aged 30 (17 - 37), underwent laparotomy.
  • The distal pancreas with tumor was cut.
  • [MeSH-minor] Adolescent. Adult. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Spleen / blood supply. Spleen / surgery. Splenic Artery / surgery. Splenic Vein / surgery. Treatment Outcome

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  • (PMID = 16681929.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Darius T, Brouwers J, Van Dijck H, Bernard P: Solid and cystic papillary neoplasm of the pancreas: a rare tumour in young women. Acta Chir Belg; 2006 Nov-Dec;106(6):726-9
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  • [Title] Solid and cystic papillary neoplasm of the pancreas: a rare tumour in young women.
  • In this paper, we present an asymptomatic young patient with solid and cystic papillary neoplasm of the pancreas.
  • In differential diagnosis, any cystic and/or solid pancreatic disease process should be considered.
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Female. Humans

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  • (PMID = 17290708.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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14. Jain R, Joseph M, Joseph S: Solid and papillary epithelial neoplasm of the pancreas--a case report. Indian J Pathol Microbiol; 2006 Jul;49(3):407-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid and papillary epithelial neoplasm of the pancreas--a case report.
  • Solid and papillary epithelial neoplasm (SPENP) of the pancreas is a rare pancreatic tumour of low malignant potential, that is seen mostly in young females.
  • Since SPENP is a low grade malignant neoplasm, it should be treated aggressively with complete resection and metastatectomy.
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Pancreatectomy

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  • (PMID = 17001901.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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15. Liu X, Rauch TM, Siegal GP, Jhala N: Solid-pseudopapillary neoplasm of the pancreas: Three cases with a literature review. Appl Immunohistochem Mol Morphol; 2006 Dec;14(4):445-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid-pseudopapillary neoplasm of the pancreas: Three cases with a literature review.
  • Solid-pseudopapillary neoplasm of the pancreas is a very rare tumor.
  • Previous immunohistochemical studies demonstrated that most solid-pseudopapillary neoplasms were immunoreactive with antibodies directed against vimentin and neuron-specific enolase.
  • Recently, expression of CD10 and CD56 in this tumor has been reported.
  • In this report, we expanded the demographic profile, highlighting 3 cases of solid-pseudopapillary neoplasm of the pancreas that presented in an elderly woman, a young man, and a young woman and further characterized them histologically and immunophenotypically.

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  • (PMID = 17122644.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 37
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16. Hauser KA, Karafa M, Seyidova-Khoshknabi D, Davis MP, Walsh D: Prevalence and risk factors of vitamin D insufficiency in cancer. J Clin Oncol; 2009 May 20;27(15_suppl):9581

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Electronic medical records of all adult solid tumor patients treated at The Cleveland Clinic in 2006-2007 were reviewed.

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  • (PMID = 27963701.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Machado MC, Machado MA, Bacchella T, Jukemura J, Almeida JL, Cunha JE: Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery; 2008 Jan;143(1):29-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients.
  • BACKGROUND: Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential.
  • METHODS: The medical records of 34 consecutive patients with pancreatic solid pseudopapillary neoplasms between 1990 and 2006 were reviewed.
  • Mean diameter of the tumor was 7 cm.
  • Tumor size tended to be smaller in patients treated in more recent years.
  • Tumor recurred in 2 patients (6%).
  • At the time of diagnosis, age was (x +/- SD) higher among male patients (25 +/- 2 years vs 37 +/- 7 years; P <.05) with no difference in tumor size.
  • There was no correlation between tumor aggressiveness and age of the patient or size of tumor.
  • CONCLUSION: This is the first single center study to demonstrate that solid pseudopapillary neoplasms in male patients have distinct patterns of onset and aggressiveness when compared with female patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Pancreatectomy. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 18154930.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Romics L Jr, Oláh A, Belágyi T, Hajdú N, Gyurus P, Ruszinkó V: Solid pseudopapillary neoplasm of the pancreas--proposed algorithms for diagnosis and surgical treatment. Langenbecks Arch Surg; 2010 Aug;395(6):747-55
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  • [Title] Solid pseudopapillary neoplasm of the pancreas--proposed algorithms for diagnosis and surgical treatment.
  • PURPOSE: The incidence of solid pseudopapillary neoplasm (SPN) of the pancreas is rising.
  • In this paper, therefore, we propose an algorithm for diagnosis and treatment of this rare type of tumor.
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 20155425.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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19. Ji Y, Zhu XZ, Lou WH, Wang DQ, Jin DY, Zeng MS, Zeng HY: [Clinicopathologic analysis of 92 cases of pancreatic cystic neoplasm]. Zhonghua Bing Li Xue Za Zhi; 2007 Mar;36(3):160-5
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  • [Title] [Clinicopathologic analysis of 92 cases of pancreatic cystic neoplasm].
  • METHODS: Ninety-two cases of cystic neoplasm of pancreas were retrieved from the Department archival file during the period from 1999 to 2005.
  • They consisted of intraductal papillary mucinous neoplasm (36/92), serous cystic neoplasm (18/92), solid pseudopapillary tumor (18/92), mucinous cystic neoplasm (14/92), cystic pancreatic ductal adenocarcinoma (4/92) and cystic pancreatic endocrine neoplasm (2/92).
  • Immunohistochemical study revealed variable staining patterns, with frequent overlaps between different tumor types.
  • In general, serous cystic neoplasm expressed MUC1, while mucinous cystic neoplasm was positive for MUC-5AC, intraductal papillary mucinous neoplasm for MUC-2 and cystic pancreatic ductal adenocarcinoma for MUC-1.
  • On the other hand, solid pseudopapillary tumor expressed alpha-antitrypsin, alpha-antichymotrypsin, vimentin and progesterone receptor.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Cystadenocarcinoma, Mucinous / metabolism. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Cystadenoma, Mucinous / metabolism. Cystadenoma, Mucinous / pathology. Cystadenoma, Serous / metabolism. Cystadenoma, Serous / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Mucin 5AC / metabolism. Young Adult

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  • (PMID = 17535681.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1
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20. Audard V, Cavard C, Richa H, Infante M, Couvelard A, Sauvanet A, Terris B, Paye F, Flejou JF: Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas. Pancreas; 2008 Jan;36(1):80-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas.
  • OBJECTIVES: To analyze in solid pseudopapillary neoplasm of the pancreas (SPNP) the consequences of the deregulated Wnt pathway by studying the expression of Wnt target glutamine synthetase (GLUL), cyclin D1, and E-cadherin, which is one of the beta-catenin binding partner in cell adhesion.
  • [MeSH-minor] Adult. Carcinoma, Pancreatic Ductal / chemistry. Carcinoma, Pancreatic Ductal / genetics. Cell Membrane / chemistry. Cyclin D1 / genetics. Cytoplasm / chemistry. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Male. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Wnt Proteins / physiology. beta Catenin / analysis. beta Catenin / physiology

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  • [CommentIn] Pancreas. 2009 Apr;38(3):338; author reply 338-9 [19307928.001]
  • (PMID = 18192886.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / Wnt Proteins; 0 / beta Catenin; 136601-57-5 / Cyclin D1; EC 6.3.1.2 / Glutamate-Ammonia Ligase
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21. Kim LC, Rix U, Haura EB: Dasatinib in solid tumors. Expert Opin Investig Drugs; 2010 Mar;19(3):415-25
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  • [Title] Dasatinib in solid tumors.
  • However, dasatinib is also being explored in solid tumors in ongoing Phase I and II clinical trials.
  • AREAS COVERED IN THIS REVIEW: The clinical efficacy of dasatinib in a wide variety of solid tumors and important Phase I/II studies utilizing dasatinib and the optimal dosage used in solid tumors.
  • TAKE HOME MESSAGE: In reviewing the clinical safety data of dasatinib in its current use as a Src inhibitor in a wide variety of solid malignancies, dasatinib appears to be safe and is a promising agent for the treatment of metastatic solid tumors refractory to standard therapies.
  • [MeSH-minor] Adult. Clinical Trials, Phase I as Topic. Clinical Trials, Phase II as Topic. Dasatinib. Humans. Neoplasm Metastasis. src-Family Kinases / antagonists & inhibitors. src-Family Kinases / metabolism

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  • (PMID = 20113198.001).
  • [ISSN] 1744-7658
  • [Journal-full-title] Expert opinion on investigational drugs
  • [ISO-abbreviation] Expert Opin Investig Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 0 / Thiazoles; EC 2.7.10.2 / src-Family Kinases; RBZ1571X5H / Dasatinib
  • [Number-of-references] 58
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22. Kim MJ, Jang SJ, Yu E: Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas. Hum Pathol; 2008 Feb;39(2):251-8
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  • [Title] Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas.
  • Solid-pseudopapillary neoplasm of the pancreas occurs preferentially in young women and has a favorable prognosis.
  • Differentiation of solid-pseudopapillary neoplasm from pancreatic endocrine neoplasm or adenocarcinoma can be difficult in the small biopsy specimen because they share common morphological features and immunoprofiles.
  • Alterations of adenomatous polyposis coli (APC)/beta-catenin pathway have been identified as a genetic event contributing to the development of solid-pseudopapillary neoplasm.
  • In the present study, to establish the diagnostic utility of beta-catenin and E-cadherin as markers for solid-pseudopapillary neoplasm, we performed immunohistochemical staining in 4 core biopsy specimens diagnosed as solid-pseudopapillary neoplasm and in tissue microarray blocks that contained histologically confirmed samples of 302 cases of adenocarcinoma, 56 cases of pancreatic endocrine neoplasm, and 50 cases of solid-pseudopapillary neoplasm.
  • Of the solid-pseudopapillary neoplasm cases, 51 (94.4%) were positive for nuclear beta-catenin, 45 (83.3%) were positive for CD10, 30 (55.5%) were positive for CD56, 15 (27.8%) were positive for synaptophysin, 3 (5.6%) were positive for cytokeratin (CK), and none was positive for E-cadherin and chromogranin.
  • Of the pancreatic endocrine neoplasm cases, 54 (96.4%) were positive for synaptophysin and E-cadherin, 50 (89.3%) were positive for chromogranin, 26 (46.4%) were positive for CK, 15 (26.8%) were positive for CD56, 6 (10.7%) were positive for CD10, and none was positive for nuclear expression of beta-catenin.
  • In conclusion, nuclear expression of beta-catenin and loss of E-cadherin can be used in the definite diagnosis of solid-pseudopapillary neoplasm on small biopsy specimens.
  • CD10 immunopositivity should be carefully interpreted in the diagnosis of solid-pseudopapillary neoplasm because pancreatic adenocarcinoma or pancreatic endocrine neoplasm can also stain for CD10.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Female. Fluorescent Antibody Technique, Indirect. Humans. Immunoenzyme Techniques. Male. Middle Aged. Tissue Array Analysis

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  • [CommentIn] Hum Pathol. 2008 Sep;39(9):1407-8 [18706351.001]
  • (PMID = 17959228.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / beta Catenin
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23. Albores-Saavedra J, Simpson KW, Bilello SJ: The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm. Am J Surg Pathol; 2006 Oct;30(10):1237-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm.
  • Solid pseudopapillary tumor is a rare but distinctive pancreatic neoplasm whose cell phenotype remains a mystery.
  • We report 3 cases of a previously undescribed variant of solid pseudopapillary tumor of the pancreas composed almost entirely of multivacuolated clear cells (>90%).
  • The tumors displayed prominent trabeculae and a solid growth pattern but lacked the characteristic pseudopapillary pattern of the classical solid pseudopapillary tumor.
  • In contrast, the clinical features, gross characteristics, and immunoprofile were similar to those of classical solid pseudopapillary tumor.
  • Two of the patients were young adult females with well-demarcated tumors involving the body and tail of the pancreas.
  • Tumor cells showed immunoreactivity for vimentin, CD10, CD56, synaptophysin, and nuclear accumulation of beta catenin.
  • Clues to distinguish the clear cell variant of solid pseudopapillary tumor from endocrine pancreatic tumor composed of clear cells, clear and foamy cell variants of ductal carcinoma, metastatic renal cell carcinoma, serous cystadenoma and ectopic adrenocortical nodules are provided.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasmic Structures / ultrastructure. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Incidental Findings. Male. Microscopy, Electron, Transmission. Pancreatectomy. Treatment Outcome

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  • (PMID = 17001153.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Gayol Mdel C, Font A, Casas I, Estrada O, Domínguez MJ, Pedro-Botet ML: [Usefulness of the MASCC scale in the management of neutropenic fever induced by chemotherapy in patients with solid neoplasm]. Med Clin (Barc); 2009 Sep 5;133(8):296-9
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  • [Title] [Usefulness of the MASCC scale in the management of neutropenic fever induced by chemotherapy in patients with solid neoplasm].
  • BACKGROUND AND OBJECTIVES: We aimed to describe chemotherapy-induced neutropenic fever (NF) in patients with solid neoplasms (SN), to validate the Multinational Association of Support Treatment in Cancer (MASCC) scale, and to evaluate whether the use of the MASCC scale was useful for reducing hospital costs for this oncologic emergency and improving the quality of life.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bacterial Infections / microbiology. Epidemiologic Methods. Female. Hospital Costs. Humans. Male. Middle Aged. Quality of Life

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  • (PMID = 19376542.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Validation Studies
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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25. Deshpande A, Munshi M: Cytology of papillary solid-cystic neoplasm of the pancreas presenting as an extrapancreatic mass: a case report. Acta Cytol; 2005 Jan-Feb;49(1):81-6
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  • [Title] Cytology of papillary solid-cystic neoplasm of the pancreas presenting as an extrapancreatic mass: a case report.
  • BACKGROUND: Papillary solid cystic neoplasm (PSCN) of the pancreas is a tumor of low malignant potential and has an excellent prognosis.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Carcinoma, Pancreatic Ductal / diagnosis. Diagnosis, Differential. Female. Humans. Staining and Labeling. Tomography, X-Ray Computed

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  • (PMID = 15717761.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Lin MY, Stabile BE: Solid pseudopapillary neoplasm of the pancreas: a rare and atypically aggressive disease among male patients. Am Surg; 2010 Oct;76(10):1075-8
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  • [Title] Solid pseudopapillary neoplasm of the pancreas: a rare and atypically aggressive disease among male patients.
  • Solid pseudopapillary neoplasm (SPN) of the pancreas is uncommon, has low metastatic potential, typically afflicts young females, and expresses progesterone receptors.
  • Ten patients underwent tumor resection with curative intent.
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Middle Aged. Pancreatectomy. Retrospective Studies. Sex Factors

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  • (PMID = 21105613.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
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27. Burford H, Baloch Z, Liu X, Jhala D, Siegal GP, Jhala N: E-cadherin/beta-catenin and CD10: a limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas. Am J Clin Pathol; 2009 Dec;132(6):831-9
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  • [Title] E-cadherin/beta-catenin and CD10: a limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas.
  • Pancreatic endocrine neoplasm (PEN) and solid pseudopapillary neoplasm of the pancreas (SPN) frequently pose diagnostic challenges.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma, Papillary / diagnosis. Neprilysin / analysis. Pancreatic Neoplasms / diagnosis. beta Catenin / analysis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged

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  • (PMID = 19926573.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cadherins; 0 / beta Catenin; EC 3.4.24.11 / Neprilysin
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28. Deshpande V, Oliva E, Young RH: Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas. Am J Surg Pathol; 2010 Oct;34(10):1514-20
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  • [Title] Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas.
  • We report 3 cases of a hitherto undescribed ovarian tumor histologically and immunohistochemically identical to pancreatic solid pseudopapillary neoplasms.
  • Grossly the neoplasms were solid and cystic.
  • The tumor cells were monotonous and the nuclei were round to oval with pale chromatin and occasional longitudinal nuclear grooves.
  • The morphologic and immunohistochemical similarity to pancreatic solid pseudopapillary neoplasm facilitates the accurate diagnosis of this rare ovarian neoplasm.
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / metabolism. Cadherins / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome. Young Adult. beta Catenin / metabolism

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  • (PMID = 20871224.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / beta Catenin
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29. Rutland B, Pollock J, Thompson L, Tucker JA, Boudreaux C: Solid-pseudopapillary tumor: a report of three cases in adult males diagnosed utilizing three different modalities. Diagn Cytopathol; 2007 Apr;35(4):234-8
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  • [Title] Solid-pseudopapillary tumor: a report of three cases in adult males diagnosed utilizing three different modalities.
  • Solid-pseudopapillary tumor of the pancreas is a rare neoplasm of uncertain origin with low malignant potential and often indolent behavior occurring predominantly in adolescent and young women.
  • Here we report the cases of three adult males with pancreatic masses, one with metastasis, diagnosed as solid-pseudopapillary tumor by cytology, electron microscopy (EM), and routine histology.
  • This neoplasm is uncommon in both males and adults and uncommonly metastasizes.
  • The cases reported emphasize the utility of different diagnostic modalities, and here we review the diagnostic features by cytology, EM, and routine histology to correctly characterize this neoplasm.
  • It is extremely important to correctly diagnose this indolent neoplasm due to the excellent prognosis with surgical resection.
  • [MeSH-minor] Adult. Humans. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Metastasis / pathology. Tomography, X-Ray Computed

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17351935.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Kuryk OH, Kucher MD, Iakovenko VO, Kriuchyna IeA: [Solid pseudopapillary epithelial pancreatic tumor]. Klin Khir; 2009 May;(5):9-13
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  • [Title] [Solid pseudopapillary epithelial pancreatic tumor].
  • Solid pseudopapillary pancreatic neoplasm-is a tumor, which appears rarely, predominantly in young women, has low malignant potential and unknown histogenesis.
  • Morphological peculiarities of the tumor may be the same as in endocrinal tumors and ductal pancreatic adenocarcinoma, with which it must be differed.
  • Immunohistochemical investigation of the tumor does not permit to obtain information for strict diferential diagnosis conduction; macroscopic and microscopic peculiarities of the tumor while staining with hematoxilin and eosin give more important information for its diagnosis.
  • The treatment is surgical and consists of radical resection of the tumor.

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  • (PMID = 19957740.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] UKR
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Cavard C, Audebourg A, Letourneur F, Audard V, Beuvon F, Cagnard N, Radenen B, Varlet P, Vacher-Lavenu MC, Perret C, Terris B: Gene expression profiling provides insights into the pathways involved in solid pseudopapillary neoplasm of the pancreas. J Pathol; 2009 Jun;218(2):201-9
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  • [Title] Gene expression profiling provides insights into the pathways involved in solid pseudopapillary neoplasm of the pancreas.
  • Solid-pseudopapillary neoplasms (SPNs) are rare human pancreatic neoplasms usually associated with a good prognosis.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Case-Control Studies. Female. Gene Expression. Humans. Male. Middle Aged. Neural Crest / metabolism. Receptors, Notch / genetics. Signal Transduction / genetics. Wnt Proteins / genetics. Young Adult. beta Catenin / genetics

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  • (PMID = 19235837.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Notch; 0 / Wnt Proteins; 0 / beta Catenin
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32. Kang CM, Yang WI, Lee YH, Choi GH, Lee SW, Kim KS, Choi JS, Lee WJ, Kim BR: A case of spleen-preserving laparoscopic distal pancreatectomy and concomitant cholecystectomy in male patient with solid pseudopapillary neoplasm of the pancreas and gallstone. J Laparoendosc Adv Surg Tech A; 2008 Apr;18(2):259-65
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  • [Title] A case of spleen-preserving laparoscopic distal pancreatectomy and concomitant cholecystectomy in male patient with solid pseudopapillary neoplasm of the pancreas and gallstone.
  • Solid pseudopapillary neoplasm is a rare pathologic condition in the pancreas.
  • The origin of this tumor and characteristic biologic behavior are still under investigation.
  • In this paper, we present a case of a 39-year-old male patient with solid pseudopapillary with (SPN) and a gallstone who successfully underwent laparoscopic distal pancreatectomy with preservation of the spleen, as well as a simultaneous cholecystectomy for the gallstone.
  • To our knowledge, this case may be the first report of the spleen preserving distal pancreatectomy in an adult male patient with SPN.
  • [MeSH-minor] Adult. Carcinoma, Papillary / complications. Carcinoma, Papillary / surgery. Humans. Male

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  • (PMID = 18373453.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Kunisaki C, Akiyama H, Nomura M, Matsuda G, Otsuka Y, Ono HA, Nagahori Y, Takahashi M, Kito F, Shimada H: Clinicopathological properties of poorly-differentiated adenocarcinoma of the stomach: comparison of solid- and non-solid-types. Anticancer Res; 2006 Jan-Feb;26(1B):639-46
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  • [Title] Clinicopathological properties of poorly-differentiated adenocarcinoma of the stomach: comparison of solid- and non-solid-types.
  • BACKGROUND: The purpose of this study was to clarify the clinicopathological and biological properties of the poorly-differentiated types of gastric carcinoma (solid-type and non-solid-type).
  • RESULTS: Patients with non-solid-type tumors tended to be younger females with peritoneal or lymph node metastases and lymphatic invasion, and with tumors that were ill-defined, of larger diameter and deeper.
  • Those patients with differentiated tumors tended to have the opposite characteristics of those patients with non-solid-type tumors.
  • Patients with solid-type tumors had intermediate characteristics.
  • The survival in patients with non-solid-type tumors was poor compared to those with differentiated or solid-type tumors.
  • There was a significant difference in the survival of stage III tumors with either solid- or non-solid-type tumors (p=0.0480).
  • CONCLUSION: Therapeutic strategies should be based on the histological type of the tumor in patients with poorly-differentiated gastric adenocarcinoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation / physiology. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis. Treatment Outcome

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  • (PMID = 16739333.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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34. Gulcelik NE, Gulcelik MA, Kuru B: Risk of malignancy in patients with follicular neoplasm: predictive value of clinical and ultrasonographic features. Arch Otolaryngol Head Neck Surg; 2008 Dec;134(12):1312-5
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  • [Title] Risk of malignancy in patients with follicular neoplasm: predictive value of clinical and ultrasonographic features.
  • OBJECTIVE: To identify clinical and ultrasonographic features that may help in predicting malignant tumors in patients with a diagnosis of follicular neoplasm on findings from fine-needle aspiration cytology (FNAC) because FNAC diagnosis of follicular neoplasm does not differentiate a benign tumor from a malignant tumor.
  • DESIGN: Prospective study of 98 patients having a diagnosis of follicular neoplasm on FNAC.
  • PATIENTS: Ninety-eight patients with thyroid nodules diagnosed by FNAC as being a follicular neoplasm.
  • Ultrasonographic features (eg, a solid echo structure, microcalcifications, and a hypoechoic pattern) were predictive for malignant neoplasms.
  • The variable associated with the highest sensitivity was the presence of a solid nodule (88.5%), and the variable associated with the highest specificity was the presence of microcalcifications (94.4%).
  • The combination of the 3 ultrasonographic features (solid echo, hypoechoic pattern, and microcalcifications) resulted in a sensitivity of 95.0% and a specificity of 98.6%.
  • Older age, male sex, solitary nodule, and larger nodule size were not predictive for malignant neoplasms in patients with follicular neoplasm cytologic findings.
  • CONCLUSIONS: We confirmed that the best compromise between the risk of missing carcinomas and the need for reducing unnecessary surgical procedures would consist of submitting to surgery those nodules presenting a solid echo structure, microcalcifications, or a hypoechoic pattern.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Thyroid Gland / pathology. Thyroid Gland / ultrasonography. Thyroid Nodule / pathology. Thyroid Nodule / ultrasonography

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  • (PMID = 19075128.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Kim JY, Lim SJ, Park K, Lee CM, Kim J: Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. Gynecol Oncol; 2005 May;97(2):337-41
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  • [Title] Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays.
  • OBJECTIVES: Cyclooxygenase-2 (COX-2) and c-erbB-2 are involved in the pathogenesis of solid organ tumors.
  • This study evaluated the significance and relationship of COX-2 and c-erbB-2 protein expression in untreated uterine cervical neoplasm.
  • METHODS: This study included 332 patients with uterine cervical neoplasm.
  • We constructed tissue microarray blocks that included two cores from each donor tumor and immunostained them with primary anti-cyclooxygenase-2 and anti-c-erbB-2 monoclonal antibodies.
  • RESULTS: Three hundred and eighteen tumor samples (95.8%) could be interpreted after immunohistochemical staining.
  • COX-2 protein expression was noted in 140 cases of uterine cervical neoplasm (44.0%): In 26.7% of the cervical intraepithelial neoplasia III (16/60 cases), 37.9% of the microinvasive squamous cell carcinoma (39/103 cases), 51.6% of the invasive squamous cell carcinoma (64/124 cases), and 76.2% of the adenocarcinomas (16/21 cases) (P < 0.005).
  • By contrast, except for one case of adenoid cystic carcinoma, none of the uterine cervical neoplasm expressed c-erbB-2 protein.
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / enzymology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / pathology. Cyclooxygenase 2. Female. Humans. Immunohistochemistry. Membrane Proteins. Microarray Analysis. Middle Aged

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  • (PMID = 15863127.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 2.7.10.1 / Receptor, ErbB-2
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36. Bacci G, Ferrari C, Longhi A, Ferrari S, Forni C, Bacchini P, Palmerini E, Briccoli A, Pignotti E, Balladelli A, Picci P: Second malignant neoplasm in patients with osteosarcoma of the extremities treated with adjuvant and neoadjuvant chemotherapy. J Pediatr Hematol Oncol; 2006 Dec;28(12):774-80
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  • [Title] Second malignant neoplasm in patients with osteosarcoma of the extremities treated with adjuvant and neoadjuvant chemotherapy.
  • Twenty-six patients (2.15%) developed a second malignant neoplasm at a median of 7.6 years (1 to 25 y) after primary osteosarcoma treatment.
  • The rate of second neoplasms was significantly higher in female patients, and the latent period shorter in hematologic tumors compared with solid tumors.
  • Our study showed that the risk of second neoplasm within 15 years increased and then leveled off and that although secondary solid tumors could be explained as unrelated cases, leukemias seem to be over represented.
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant / methods. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Incidence. Infant. Male. Neoplasms / drug therapy. Neoplasms / epidemiology. Retrospective Studies. Risk Factors. Sex Factors. Time Factors

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  • (PMID = 17164644.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Han HS, Min SK, Lee HK, Kim SW, Park YH: Laparoscopic distal pancreatectomy with preservation of the spleen and splenic vessels for benign pancreas neoplasm. Surg Endosc; 2005 Oct;19(10):1367-9
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  • [Title] Laparoscopic distal pancreatectomy with preservation of the spleen and splenic vessels for benign pancreas neoplasm.
  • METHODS: From May 2000 to July 2003, five laparoscopic distal pancreatectomies with preservation of the spleen and splenic vessels were performed for benign pancreas neoplasm at Ewha Womans University Mokdong Hospital in Seoul, Korea.
  • RESULTS: The postoperative pathologic diagnoses were two serous cystadenomas, two mucinous cystadenomas, and one solid and papillary epithelial tumor.
  • CONCLUSION: Laparoscopic distal pancreatectomy with preservation of the spleen and splenic vessels is a relatively safe and feasible option for the management of benign tumor or borderline malignancy in the distal pancreas.
  • [MeSH-minor] Adult. Feasibility Studies. Female. Humans. Male. Middle Aged. Spleen / blood supply

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  • (PMID = 16193376.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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38. Hernández-Puente A, Artigas V, Moral A, Magarzo J, Targarona E, Trías M: [Solid-pseudopapillary tumor of pancreas]. Cir Esp; 2005 Apr;77(4):233-5
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  • [Title] [Solid-pseudopapillary tumor of pancreas].
  • [Transliterated title] Tumor sólido seudopapilar del páncreas.
  • Solid-pseudopapillary tumor of pancreas is a very rare neoplasm of low malignant potential and unknown origin.
  • Two cases of solid pseudopapillary tumor with distinct disease duration are reported.
  • [MeSH-minor] Adult. Female. Humans. Middle Aged

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  • (PMID = 16420924.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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39. Shimanovich I, Krahl D, Rose C: Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors. J Am Acad Dermatol; 2010 Feb;62(2):277-83
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  • [Title] Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors.
  • BACKGROUND: Trichoadenoma is a rare benign follicular tumor first described by Nikolowski 50 years ago.
  • In trichoadenoma the cystic component predominates, while desmoplastic trichoepithelioma is a mostly solid neoplasm.
  • Trichoadenoma is a distinct follicular tumor related but not identical to desmoplastic trichoepithelioma.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Head and Neck Neoplasms / pathology. Humans. Immunohistochemistry. Keratin-20 / metabolism. Male. Merkel Cells / pathology. Middle Aged. Neoplasms, Fibroepithelial / pathology. Receptors, Androgen / metabolism. Skin / chemistry

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  • [Copyright] Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20115950.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AR protein, human; 0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Receptors, Androgen; 0 / human epithelial antigen-125
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40. Kawamoto S, Lawler LP, Horton KM, Eng J, Hruban RH, Fishman EK: MDCT of intraductal papillary mucinous neoplasm of the pancreas: evaluation of features predictive of invasive carcinoma. AJR Am J Roentgenol; 2006 Mar;186(3):687-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MDCT of intraductal papillary mucinous neoplasm of the pancreas: evaluation of features predictive of invasive carcinoma.
  • OBJECTIVE: The purpose of our study was to evaluate factors predictive of the presence of invasive carcinoma associated with intraductal papillary mucinous neoplasm (IPMN) of the pancreas on MDCT.
  • Type of ductal involvement, location, tumor size in branch duct type and combined type lesions, caliber of the main pancreatic duct, caliber of the common bile duct or common hepatic duct, and solid appearance of the lesion were assessed on CT and correlated with pathologic findings for invasive carcinoma.
  • With invasive carcinoma, the size of the tumor in branch duct type and combined type, and the caliber of the main pancreatic duct were significantly larger compared with the lesions without invasive carcinoma (4.7 +/- 1.7 cm vs 2.6 +/- 1.4 cm [p = 0.0007] and 9.3 +/- 5.5 mm vs 4.6 +/- 4.1 mm [p = 0.006], respectively).
  • A solid mass (p < 0.001), dilatation of the common bile duct or common hepatic duct (> or = 15 mm), and the presence of a stent (p = 0.0004) were correlated with the presence of associated invasive carcinoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16498096.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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41. Souweidane MM, Luther N: Endoscopic resection of solid intraventricular brain tumors. J Neurosurg; 2006 Aug;105(2):271-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of solid intraventricular brain tumors.
  • It is generally expected that endoscopic removal of solid brain tumors from the intraventricular compartment would impose additional technical demands.
  • In this paper, the feasibility and safety of endoscopic removal of solid intraventricular brain tumors is evaluated.
  • METHODS: Eighty-one patients who underwent endoscopic management of an intraventricular brain tumor were identified from a prospective database.
  • Of these patients, seven underwent attempted endoscopic surgical removal of a solid primary brain tumor.
  • Five patients underwent complete resection of a solid intraventricular brain tumor, a treatment option that was based on intraoperative assessment and confirmed by postoperative imaging.
  • Maximum tumor diameter ranged from 0.5 to 1.8 cm for patients who underwent complete resection, whereas maximum tumor diameter measured 2.4 and 2.5 cm in the two patients in whom a subtotal excision was performed.
  • CONCLUSIONS: In select patients, complete endoscopic removal of solid intraventricular brain tumors is possible and safe.
  • Factors that influence the ability of a surgeon to perform a complete endoscopic resection include tumor size, composition, and vascularity.
  • [MeSH-minor] Adult. Cerebral Ventricles / pathology. Cerebral Ventricles / surgery. Cohort Studies. Feasibility Studies. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm, Residual / diagnosis. Postoperative Complications / diagnosis. Prospective Studies. Surgical Instruments. Treatment Outcome

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  • (PMID = 17219833.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. De Sio L, Milano GM, Castellano A, Jenkner A, Fidani P, Dominici C, Donfrancesco A: Temozolomide in resistant or relapsed pediatric solid tumors. Pediatr Blood Cancer; 2006 Jul;47(1):30-6
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  • [Title] Temozolomide in resistant or relapsed pediatric solid tumors.
  • PURPOSE: We report the off-label study aimed at investigating the use of temozolomide (TMZ) as single agent in relapsed or resistant pediatric solid tumors.
  • PATIENTS AND METHODS: Fifty two patients, median age 127.6 months, with resistant or relapsed solid tumors were enrolled.
  • Tumor types were: neuroblastoma (NB; n = 17), medulloblastoma (MB; 8), brain stem glioma (BSG; 8), extraosseous Ewing's sarcoma/peripheral neuroectodermal tumor (EOES; 4), Ewing's sarcoma (ES; 4), anaplastic astrocytoma (AA; 3), rhabdomyosarcoma (RMS; 2), ependymoma (EP; 2), cerebral primitive neuroectodermal tumor (cPNET; 2), hepatocarcinoma (HC; 1), and osteosarcoma (OS; 1).
  • CONCLUSION: Oral TMZ was well tolerated in children with resistant or relapsed solid tumors and showed activity in NB and CNS tumours refractory to standard chemotherapy.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Dacarbazine / analogs & derivatives. Drug Resistance, Neoplasm. Neoplasm Recurrence, Local / drug therapy. Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Dose-Response Relationship, Drug. Female. Humans. Male. Survival Analysis

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • [ErratumIn] Pediatr Blood Cancer. 2006 Oct 15;47(5):647-8
  • (PMID = 16047361.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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43. Seo HE, Lee MK, Lee YD, Jeon SW, Cho CM, Tak WY, Kweon YO, Kim SK, Choi YH, Bae HI, Kim SG, Yoon YK: Solid-pseudopapillary tumor of the pancreas. J Clin Gastroenterol; 2006 Nov-Dec;40(10):919-22
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  • [Title] Solid-pseudopapillary tumor of the pancreas.
  • BACKGROUND: Solid-pseudopapillary tumor (SPT) of the pancreas is a low-grade malignancy, which has been infrequently observed in adolescent and young adult females since first report by Frantz in 1959.
  • CONCLUSIONS: SPT of the pancreas is an unusual neoplasm and typically occurs in young females presenting well-demarcated pancreatic masses, which are amenable to cure by complete surgical resection.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / blood. Child. Colectomy. Diagnostic Errors. Endoscopy, Gastrointestinal. Female. Follow-Up Studies. Humans. Korea. Leiomyosarcoma / diagnosis. Male. Medical Records. Middle Aged. Pancreatectomy. Peritoneal Neoplasms / diagnosis. Retrospective Studies. Splenectomy. Stomach Neoplasms / diagnosis. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Interventional

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  • (PMID = 17063112.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Koo L, Hatton MP, Rubin PA: "Pseudo-pseudochalazion": giant chalazion mimicking eyelid neoplasm. Ophthal Plast Reconstr Surg; 2005 Sep;21(5):391-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Pseudo-pseudochalazion": giant chalazion mimicking eyelid neoplasm.
  • A 33-year-old man presented with a solid lesion encompassing the entire left upper eyelid.
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Glucocorticoids / therapeutic use. Granuloma / diagnosis. Granuloma / drug therapy. Humans. Male. Retreatment. Triamcinolone Acetonide / therapeutic use

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  • (PMID = 16234710.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; F446C597KA / Triamcinolone Acetonide
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45. Vajtai I, Sahli R, Kappeler A, Christ ER, Seiler RW: Leiomyomatoid angiomatous neuroendocrine tumor (LANT) of the pituitary: a distinctive biphasic neoplasm with primitive secretory phenotype and smooth muscle-rich stroma. Acta Neuropathol; 2006 Mar;111(3):278-83
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  • [Title] Leiomyomatoid angiomatous neuroendocrine tumor (LANT) of the pituitary: a distinctive biphasic neoplasm with primitive secretory phenotype and smooth muscle-rich stroma.
  • We describe a hitherto undocumented variant of dimorphic pituitary neoplasm composed of an admixture of neurosecretory cells and profuse leiomyomatous stroma around intratumoral vessels.
  • Histologically, solid sheets, nests and cords of epithelial-looking, yet cytokeratin-negative cells were seen growing in a richly vascularized stroma of spindle cells.
  • Except for alpha-subunit, anterior pituitary hormones tested negative in tumor cells, as did a panel of peripheral endocrine markers, including serotonin, somatostatin, calcitonin, parathormone and vasoactive intestinal polypeptide.
  • While assignment of this lesion to any established neoplastic entity is not forthcoming, we propose it is being considered as a low-grade neuroendocrine tumor possibly related to null cell adenoma.
  • [MeSH-minor] Actins / metabolism. Adult. Female. Hemangioma / pathology. Humans. Leiomyoma / pathology. Muscle, Smooth / pathology. Phenotype. Vimentin / metabolism

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  • (PMID = 16520966.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Vimentin
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46. Kim JY, Lim SJ, Kim HJ, Shin E, Park K, Lee CM: Clinical significance of p27 and Skp2 protein expression in uterine cervical neoplasm. Int J Gynecol Pathol; 2007 Jul;26(3):242-7
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  • [Title] Clinical significance of p27 and Skp2 protein expression in uterine cervical neoplasm.
  • The loss of p27 indicates a poor prognosis in various solid tumors, and a decrease in p27 level is the result of increased degradation by Skp2.
  • We evaluated the relationship of p27 and Skp2 protein expression to various clinicopathologic factors in 332 cases of untreated uterine cervical neoplasm using tissue microarray method.
  • After immunohistochemical staining, 313 and 300 tumor samples were retrieved for interpretation for p27 and Skp2, respectively.
  • High p27 protein expression (nuclear staining in more than 30% of the tumor cells) was seen in 39.9% (125/313 cases), including 32 cervical intraepithelial neoplasia (CIN) III (55.2%), 58 microinvasive squamous cell carcinoma (SCC) (56.9%), 21 invasive SCC (17.1%), 11 adenocarcinoma (55.0%), and 3 cases of other tumors (30.0%).
  • Low p27 protein expression was correlated with large tumor size (P < 0.005), depth of invasion in squamous lesion (P < 0.0005), high stage (P < 0.0005), and poor survival (P < 0.005).
  • High Skp2 protein expression was correlated with large tumor size (P < 0.05), depth of invasion in squamous lesion (P < 0.05), and high stage (P < 0.005), but not with patient survival.
  • Only tumor stage had prognostic significance in the multivariate analysis (P = 0.041).
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Cervical Intraepithelial Neoplasia / metabolism. Cervical Intraepithelial Neoplasia / pathology. Female. Humans. Immunohistochemistry. Middle Aged. Prognosis

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  • (PMID = 17581405.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S-Phase Kinase-Associated Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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47. Irving JA, Young RH: Microcystic stromal tumor of the ovary: report of 16 cases of a hitherto uncharacterized distinctive ovarian neoplasm. Am J Surg Pathol; 2009 Mar;33(3):367-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcystic stromal tumor of the ovary: report of 16 cases of a hitherto uncharacterized distinctive ovarian neoplasm.
  • On the basis of our extensive experience with ovarian tumors, the neoplasm is unique and warrants separate categorization; we have elected to designate it "microcystic stromal tumor" because of its most striking feature.
  • The tumors were solid-cystic (11 cases), solid (3 cases), or predominantly cystic (2 cases).
  • The solid component was usually firm and tan or white-tan, but in 1 case was yellowish; soft foci were present in 3 cases and small foci of hemorrhage, necrosis, or both, in 3.
  • On microscopic examination the appearance of the tumors varied according to the relative prominence of their 3 fundamental components: microcysts, solid cellular regions, and fibrous stroma.
  • The solid cellular areas were usually focally intersected by fibrous bands and hyaline plaques reminiscent of thecoma.
  • For tumors which have been well sampled and exhibit (1) a microcystic pattern and regions with lobulated cellular masses with intervening, sometimes hyalinized fibrous stroma, (2) an absence of morphologic features enabling any other specific diagnosis in the sex cord-stromal category, (3) an absence of epithelial elements, and (4) an absence of teratomatous or other germ cell elements, we propose the designation "microcystic stromal tumor."
  • They represent, in addition to the sclerosing stromal tumor (segregated out 3 decades ago), a distinctive subtype of ovarian tumor, likely also belonging to the stromal category based on current evidence.
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 18971779.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Alexandrescu DT, O'Boyle K, Feliz A, Fueg A, Wiernik PH: Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management. Clin Oncol (R Coll Radiol); 2005 Aug;17(5):358-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management.
  • Solid-pseudopapillary tumour of the pancreas is a rare neoplasm of young women, currently categorised in the World Health Organization classification under exocrine pancreatic tumours.
  • We describe two patients with solid-pseudopapillary tumour of the pancreas.
  • A literature review was carried out, and the main clinico-pathological features and strategies of treatment of solid-pseudopapillary tumour of the pancreas are presented.
  • Pathological, genetic and molecular features distinguish solid-pseudopapillary tumours from pancreatic ductal adenocarcinoma.
  • Furthermore, neuroendocrine differentiation can be found focally in occasional cases of solid-pseudopapillary tumour.
  • However, the indolent clinical progression of solid-pseudopapillary tumours is similar to that of pancreatic neuroendocrine tumour.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16097567.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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49. Shchegolev AI, Dubova EA, Mishnev OD: [Clinical and morphological characteristics of solid pseudopapillary tumors of the pancreas]. Arkh Patol; 2009 Jan-Feb;71(1):23-8
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  • [Title] [Clinical and morphological characteristics of solid pseudopapillary tumors of the pancreas].
  • The paper presents the results of a comprehensive morphological study of the surgical material from 9 patients (females aged 19 to 67 years) with solid pseudopapillary tumors of the pancreas.
  • Microscopically, the tumor appears predominantly as solid structure areas and pseudopapillae.
  • [MeSH-major] Neoplasm Proteins / metabolism. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry / methods. Male. Middle Aged

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  • (PMID = 19514354.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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50. Machado MC, Machado MA: Solid serous adenoma of the pancreas: an uncommon but important entity. Eur J Surg Oncol; 2008 Jul;34(7):730-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid serous adenoma of the pancreas: an uncommon but important entity.
  • Serous cystic neoplasms of the pancreas have currently five recognized subtypes: serous microcystic adenoma, serous oligocystic ill-demarcated adenoma, solid serous adenoma, von Hippel-Lindau-associated cystic neoplasm, and serous cystadenocarcinoma.
  • Solid serous adenoma of the pancreas is by far the rarest subtype with only nine cases published thus far.
  • After analyzing the literature, including one case from our Department, we can conclude that there is enough evidence to support that solid serous adenomas of the pancreas is a solid variant of serous cystadenomas.
  • Given benign nature of this solid variant conservative surgery is recommended.
  • It is definitively a rare entity but oncologic surgeons should be aware of this neoplasm in order to make a correct preoperative diagnosis that will ultimately result in more conservative surgeries.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18440191.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 12
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51. Hernandez JM, Centeno BA, Kelley ST: Solid pseudopapillary tumors of the pancreas: case presentation and review of the literature. Am Surg; 2007 Mar;73(3):290-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid pseudopapillary tumors of the pancreas: case presentation and review of the literature.
  • Solid-pseudopapillary tumors of the pancreas are a rare pancreatic neoplasm that carries a 95 per cent 5-year survival rate.
  • However, despite the excellent overall prognosis, aggressive variants been described that likely represent malignant degeneration in an otherwise indolent tumor.
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17375791.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Choi JY, Kim MJ, Kim JH, Kim SH, Lim JS, Oh YT, Chung JJ, Yoo HS, Lee JT, Kim KW: Solid pseudopapillary tumor of the pancreas: typical and atypical manifestations. AJR Am J Roentgenol; 2006 Aug;187(2):W178-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid pseudopapillary tumor of the pancreas: typical and atypical manifestations.
  • OBJECTIVE: The purpose of this pictorial essay is to illustrate the various appearances of solid pseudopapillary tumor of the pancreas.
  • CONCLUSION: Solid pseudopapillary tumor of the pancreas is a rare neoplasm usually found in young women.
  • Typical solid pseudopapillary tumor is characterized by a well-encapsulated mass with varying amounts of intratumoral hemorrhage.
  • However, the tumor can have an atypical appearance, such as metastasis, ductal obstruction, parenchymal and extracapsular invasion, simulation of islet cell tumor, intratumoral calcification, and occurrence in a male patient.
  • The typical and atypical manifestations of solid pseudopapillary tumor can be visualized with cross-sectional imaging.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16861508.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Herbst RS, Hong D, Chap L, Kurzrock R, Jackson E, Silverman JM, Rasmussen E, Sun YN, Zhong D, Hwang YC, Evelhoch JL, Oliner JD, Le N, Rosen LS: Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol; 2009 Jul 20;27(21):3557-65
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  • [Title] Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors.
  • This first-in-human study evaluated the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of AMG 386 in adults with advanced solid tumors.
  • One occurrence of dose-limiting toxicity was seen at 30 mg/kg: respiratory arrest, which likely was caused by tumor burden that was possibly related to AMG 386.
  • One patient with refractory ovarian cancer achieved a confirmed partial response (ie, 32.5% reduction by Response Evaluation Criteria in Solid Tumors) and withdrew from the study with a partial response after 156 weeks of treatment; four patients experienced stable disease for at least 16 weeks.
  • AMG 386 also appeared to impact tumor vascularity and showed antitumor activity in this patient population.
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal, Humanized. Antimetabolites, Antineoplastic / adverse effects. Antimetabolites, Antineoplastic / pharmacokinetics. Bevacizumab. Dose-Response Relationship, Drug. Drug-Related Side Effects and Adverse Reactions. Female. Humans. Infusions, Intravenous. Male. Maximum Tolerated Dose. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 19546406.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Angiopoietins; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antimetabolites, Antineoplastic; 2S9ZZM9Q9V / Bevacizumab
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54. Jacobs JF, Coulie PG, Figdor CG, Adema GJ, de Vries IJ, Hoogerbrugge PM: Targets for active immunotherapy against pediatric solid tumors. Cancer Immunol Immunother; 2009 Jun;58(6):831-41
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  • [Title] Targets for active immunotherapy against pediatric solid tumors.
  • In the last decennia new strategies have been developed for the use of tumor-specific T cells and antibodies in cancer therapy.
  • Effective anti-tumor immunotherapy requires the identification of suitable target antigens.
  • The expression of tumor-specific antigens has been extensively studied for most types of adult tumors.
  • So far, these patients do not benefit enough from the progresses in cancer immunotherapy, and one of the reasons is the paucity of tumor-specific antigens identified on pediatric tumors.
  • In this review we discuss the current status of cancer immunotherapy in children, focusing on the identification of tumor-specific antigens on pediatric solid tumors.
  • [MeSH-minor] Antigens, Neoplasm / immunology. Child. Clinical Trials as Topic. Humans

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  • (PMID = 19009292.001).
  • [ISSN] 1432-0851
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
  • [Number-of-references] 139
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55. Goh BK, Tan YM, Cheow PC, Chung AY, Chow PK, Wong WK, Ooi LL: Solid pseudopapillary neoplasms of the pancreas: an updated experience. J Surg Oncol; 2007 Jun 15;95(8):640-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid pseudopapillary neoplasms of the pancreas: an updated experience.
  • METHODS: Sixteen consecutive patients who underwent surgery for a pathologically confirmed solid pseudopapillary neoplasm (SPPN) were retrospectively reviewed.
  • The tumors appeared on cross-sectional imaging as solid and cystic (n = 14) or cystic (n = 2) masses.
  • The median tumor size was 9.5 cm (range, 5.0-24.0 cm).
  • CONCLUSION: SPPNs should be considered in young women presenting with a large solid-cystic pancreatic mass.
  • [MeSH-minor] Adolescent. Adult. Colectomy. Female. Humans. Male. Middle Aged. Omentum / surgery. Portal Vein / surgery. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright 2007 Wiley-Liss, Inc.
  • (PMID = 17477365.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Tang WW, Stelter AA, French S, Shen S, Qiu S, Venegas R, Wen J, Wang HQ, Xie J: Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. Mod Pathol; 2007 May;20(5):509-13
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  • [Title] Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas.
  • Solid pseudopapillary tumor of pancreas (SPT) is a rare neoplasm that occurs most often in young females with the two distinct features, the 'solid-cystic' gross appearance, and the 'solid-pseudopapillary' microscopic pattern.
  • It has been reported that almost all SPT tumors contain a mutation in the beta-catenin gene; however, the histogenetic origin of this tumor remains largely a mystery.
  • In this study, we examined the expression of E-cadherin and beta-catenin from SPT in an attempt to determine the molecular basis for the unusual morphology of this tumor.
  • Immunostains showed that, in both solid and pseudopapillary areas, all the tumor cells lost expression of E-cadherin, and beta-catenin nuclear expression was observed in all cases.
  • Our findings suggest that loss of cytoplasmic beta-catenin protein in the cell adhesion complex due to beta-catenin gene mutation, results in instability of the complex, loss of E-cadherin in cell membrane, and eventually dissociation of the tumor cells to form the pseudopapillary pattern.
  • [MeSH-minor] Adult. Cadherins / genetics. Cadherins / metabolism. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mutation. Reverse Transcriptase Polymerase Chain Reaction. beta Catenin / genetics. beta Catenin / metabolism

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  • (PMID = 17334348.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / R01-94160
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / Cell Adhesion Molecules; 0 / beta Catenin
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57. Palazzo FF, Sebag F, Sierra M, Ippolito G, Souteyrand P, Henry JF: Long-term outcome following laparoscopic adrenalectomy for large solid adrenal cortex tumors. World J Surg; 2006 May;30(5):893-8

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  • [Title] Long-term outcome following laparoscopic adrenalectomy for large solid adrenal cortex tumors.
  • Patients who underwent LA for solid cortical tumors > or = 60 mm in diameter without preoperative or intraoperative evidence of malignancy were reviewed.
  • Among them, 19 were solid cortical tumors > or = 60 mm in diameter with no overt malignant preoperative or intraoperative characteristics: 9 nonsecreting tumors, 8 Cushing's syndrome tumors (including 2 virilizing variants), 1 virilizing tumor, and 1 aldosteronoma.
  • The mean age of the patients was 49.9 years (range 22-77 years), and the mean tumor size was 69.0 mm (range 60-80 mm).
  • CONCLUSIONS: Laparoscopic adrenalectomy for large solid cortical tumors without pre- or intraoperative evidence of malignancy is not contraindicated, and it is unlikely to have a deleterious effect on long-term outcome.
  • [MeSH-minor] Adult. Aged. Algorithms. Humans. Laparoscopy. Middle Aged. Neoplasm Staging. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 16680605.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Reichelt O, Gajda M, Chyhrai A, Wunderlich H, Junker K, Schubert J: Ultrasound-guided biopsy of homogenous solid renal masses. Eur Urol; 2007 Nov;52(5):1421-6
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  • [Title] Ultrasound-guided biopsy of homogenous solid renal masses.
  • OBJECTIVES: We evaluated the reliability of sonographic criteria in selecting solid renal masses for percutaneous fine-needle biopsy.
  • The main tumor was intraoperatively evaluated by B-mode and power Doppler sonography.
  • By applying these results to 30 patients of study 2 (18 men, 12 women; aged 63+/-7.7 yr, tumor size 29+/-11.3mm) who met these sonographic criteria on preoperative transabdominal ultrasound, we bioptically diagnosed 8 (26.7%) benign tumors; 25 of 30 (83.3%) patients were accurately diagnosed.
  • Ultrasound-guided percutaneous biopsy of these solid renal masses could determine renal tumor patients for whom surveillance might be an option.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Nephrectomy / methods. Prospective Studies. Reproducibility of Results

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  • [CommentIn] Eur Urol. 2007 Nov;52(5):1426-7 [17306923.001]
  • (PMID = 17306920.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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59. Vargas-Serrano B, Domínguez-Ferreras E, Chinchón-Espino D: Four cases of solid pseudopapillary tumors of pancreas: imaging findings and pathological correlations. Eur J Radiol; 2006 Apr;58(1):132-9
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  • [Title] Four cases of solid pseudopapillary tumors of pancreas: imaging findings and pathological correlations.
  • OBJECTIVE: Solid pseudopapillary tumor of the pancreas (SPTP tumor) is a rare pancreatic neoplasm with low malignant potential, which usually affects female patients in the second or third decades of life.
  • It is a non-functional, slow-growing neoplasm that very often reaches considerable size before the first symptoms appear.
  • Symptomatology is frequently related to tumor size.
  • Infrequently the tumor can appear in male patients or in aged women, which can make the diagnosis more difficult.
  • RESULTS: Four cases of solid pseudopapillary tumor of the pancreas were diagnosed and treated in our institution in the study period.
  • CONCLUSION: Solid pseudopapillary tumors are well-encapsulated neoplasms that usually have a good prognosis after surgical excision.
  • [MeSH-minor] Adult. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16377114.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
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60. di Pietro A, Vries EG, Gietema JA, Spierings DC, de Jong S: Testicular germ cell tumours: the paradigm of chemo-sensitive solid tumours. Int J Biochem Cell Biol; 2005 Dec;37(12):2437-56
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  • [Title] Testicular germ cell tumours: the paradigm of chemo-sensitive solid tumours.
  • Testicular germ cell tumours (TGCTs) are the most frequent solid malignant tumour in men 20-40 years of age and the most frequent cause of death from solid tumours in this age group.
  • The majority of metastatic testicular cancer patients, in contrast to most other metastatic solid tumours, can be cured with highly effective cisplatin-based chemotherapy.
  • From a genetic point of view, almost all TGCTs in contrast to solid tumours are characterised by the presence of wild type p53.
  • Taken together, this provides TGCT as a tumour type model to investigate and understand the molecular determinants of chemotherapy sensitivity of solid tumours.
  • [MeSH-minor] Adult. Animals. Apoptosis. Carcinoma in Situ / physiopathology. Cell Cycle / physiology. Cell Line, Tumor. DNA-Binding Proteins / physiology. Genes, Neoplasm. Genes, Tumor Suppressor / physiology. Humans. Male. Membrane Proteins / physiology. Mice. Nuclear Proteins / physiology. Testis / cytology. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Tumor Suppressor Proteins

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  • (PMID = 16099193.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / DNA-Binding Proteins; 0 / Membrane Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 202
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61. Chung YE, Kim MJ, Choi JY, Lim JS, Hong HS, Kim YC, Cho HJ, Kim KA, Choi SY: Differentiation of benign and malignant solid pseudopapillary neoplasms of the pancreas. J Comput Assist Tomogr; 2009 Sep-Oct;33(5):689-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiation of benign and malignant solid pseudopapillary neoplasms of the pancreas.
  • OBJECTIVE: The aim of this study was to investigate differential imaging features between benign and malignant solid pseudopapillary neoplasms (SPN) of the pancreas on computed tomographic and magnetic resonance imagings.
  • Each tumor was analyzed for the following categories: location of tumor, tumor margin, proportion of solid component, morphology of capsule, growth pattern, calcification, and presence of upstream pancreatic ductal dilatation.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Calcinosis / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Logistic Models. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness / diagnosis. Pancreatectomy. Pancreatic Diseases / diagnosis. Pancreatic Diseases / pathology. Treatment Outcome. Young Adult

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  • (PMID = 19820493.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Salvia R, Bassi C, Festa L, Falconi M, Crippa S, Butturini G, Brighenti A, Capelli P, Pederzoli P: Clinical and biological behavior of pancreatic solid pseudopapillary tumors: report on 31 consecutive patients. J Surg Oncol; 2007 Mar 15;95(4):304-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and biological behavior of pancreatic solid pseudopapillary tumors: report on 31 consecutive patients.
  • BACKGROUND: Solid pseudopapillary tumors (SPTs) represent one of the most uncommon histotypes of all exocrine pancreatic neoplasms.
  • RESULTS: Tumor detection was incidental in the 55% of cases.
  • The neoplasm was localized in the pancreatic head in 10 patients and in the body-tail in 20 cases; the main diameter ranged from 2 to 20 cm (mean 5.4).
  • At the radiological work-up, the neoplasm was solid in 87% of cases and delimited by a capsule in 39%.
  • CONCLUSIONS: Solid pseudopapillary tumor (SPT) is an indolent neoplasm with low-grade biological aggressiveness, making surgical treatment successful despite its large size.
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17326131.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Génébès C, Brouchet L, Kamar N, Lepage B, Prévot G, Rostaing L, Didier A, Mazières J: Characteristics of thoracic malignancies that occur after solid-organ transplantation. J Thorac Oncol; 2010 Nov;5(11):1789-95
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  • [Title] Characteristics of thoracic malignancies that occur after solid-organ transplantation.
  • BACKGROUND: Chronic immunosuppression after solid-organ transplantation is associated with increased risk of developing malignancies.
  • The purpose of this study was to determine the clinical characteristics and the outcome of thoracic malignancies in patients who have undergone solid-organ transplantation.
  • CONCLUSION: Solid-organ transplantation is associated with a high risk of lung cancer and may have an important synergetic part with other risk factors for lung cancer (tobacco).
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Survival Rate

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  • (PMID = 20975378.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Benesch M, Windelberg M, Sauseng W, Witt V, Fleischhack G, Lackner H, Gadner H, Bode U, Urban C: Compassionate use of bevacizumab (Avastin) in children and young adults with refractory or recurrent solid tumors. Ann Oncol; 2008 Apr;19(4):807-13
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  • [Title] Compassionate use of bevacizumab (Avastin) in children and young adults with refractory or recurrent solid tumors.
  • PATIENTS AND METHODS: Fifteen patients (male: n = 8; female: n = 7; median age, 14.6 years) received bevacizumab for recurrent or progressive solid tumors (carcinoma: n = 3; neuroblastoma: n = 2; astrocytoma grade III: n = 2; rhabdomyosarcoma: n = 2; nephroblastoma: n = 2; benign vascular tumors: n = 2; synovial sarcoma: n = 1; and malignant hemangiopericytoma: n = 1) on a compassionate basis.
  • CONCLUSIONS: Bevacizumab seems to have a good acute safety profile and some antitumor activity in heavily pretreated children and young adults with recurrent solid tumors.

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  • (PMID = 18056650.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab
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65. Waki F, Ando M, Takashima A, Yonemori K, Nokihara H, Miyake M, Tateishi U, Tsuta K, Shimada Y, Fujiwara Y, Tamura T: Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors. J Neurooncol; 2009 Jun;93(2):205-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors.
  • BACKGROUND: Leptomeningeal metastasis (LM) occurs in 4-15% of patients with solid tumors.
  • The purpose of this study was to identify the prognostic factors in patients with solid tumors with cytologically proven LM.
  • [MeSH-major] Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / secondary. Neoplasm Metastasis / pathology. Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brain Neoplasms / mortality. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Breast Neoplasms / mortality. Breast Neoplasms / pathology. Female. Humans. Lung Neoplasms / mortality. Lung Neoplasms / pathology. Male. Middle Aged. Prognosis. Retrospective Studies. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / secondary. Stomach Neoplasms / mortality. Stomach Neoplasms / pathology. Survival Analysis. Time Factors. Young Adult

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  • (PMID = 19043775.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Zhang YW, Yan DL, Sun L, Zheng SW, Xue HZ, Wang XH, Wang TH: [Clinical features and prognosis of solid-pseudopapillary tumor of the pancreas]. Zhonghua Zhong Liu Za Zhi; 2010 Jun;32(6):444-7
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  • [Title] [Clinical features and prognosis of solid-pseudopapillary tumor of the pancreas].
  • OBJECTIVE: To study the clinicopathological and immunohistochemical features, histogenesis and biological behavior, clinical treatment and prognosis of solid pseudopapillary tumor of the pancreas (SPT).
  • Tumors were encapsulated and mixed with solid and cystic tissues.
  • A Kaplan-Meier analysis revealed that patient's age, tumor size, pathologic features, metastasis were major prognostic factors for SPT.
  • CONCLUSION: SPT is a tumor of low-grade malignancy and may be derived from multipotent stem cells.
  • [MeSH-major] Carcinoma, Papillary. Neoplasm Recurrence, Local / surgery. Pancreatectomy / methods. Pancreatic Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Reoperation. Retrospective Studies. Survival Rate. Vimentin / metabolism. Young Adult. alpha 1-Antichymotrypsin / metabolism. alpha 1-Antitrypsin / metabolism

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  • (PMID = 20819487.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Vimentin; 0 / alpha 1-Antichymotrypsin; 0 / alpha 1-Antitrypsin
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67. Dapprich DC, Weenig RH, Rohlinger AL, Weaver AL, Quan KK, Keeling JH, Walsh JS, Otley CC, Christenson LJ: Outcomes of melanoma in recipients of solid organ transplant. J Am Acad Dermatol; 2008 Sep;59(3):405-17
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  • [Title] Outcomes of melanoma in recipients of solid organ transplant.
  • BACKGROUND: There is concern that the immunologic tumor malignant melanoma (MM) may have worse outcomes in immunosuppressed hosts than in the general population.
  • OBJECTIVE: We sought to describe outcomes of MM in immunosuppressed solid organ transplant recipients and compare them with the general population.
  • METHODS: We conducted a retrospective review of medical charts and pathology slides of cases of MM and solid organ transplantation between 1978 and 2007, with comparison of outcomes.
  • [MeSH-minor] Adult. Aged. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Retrospective Studies. Time Factors. United States

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  • (PMID = 18556089.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Schulte M, von Baer A, Schultheiss M, Scheil-Bertram S: [Classification of solid soft tissue tumours by ultrasonography]. Ultraschall Med; 2010 Apr;31(2):182-90
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  • [Title] [Classification of solid soft tissue tumours by ultrasonography].
  • MATERIALS AND METHODS: In a prospective study over a period of 8 years 224 histologically ascertained solid soft tissue tumours, thereof 120 sarcomas and 27 aggressive benign lesions were investigated by B-mode and colour Doppler sonography.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Lymphoma, Non-Hodgkin / classification. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / ultrasonography. Male. Middle Aged. Neoplasm Staging. Neovascularization, Pathologic / classification. Neovascularization, Pathologic / pathology. Neovascularization, Pathologic / ultrasonography. Prospective Studies. Sensitivity and Specificity. Young Adult

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  • [Copyright] Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20306381.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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69. Yang F, Fu DL, Jin C, Long J, Yu XJ, Xu J, Ni QX: Clinical experiences of solid pseudopapillary tumors of the pancreas in China. J Gastroenterol Hepatol; 2008 Dec;23(12):1847-51
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  • [Title] Clinical experiences of solid pseudopapillary tumors of the pancreas in China.
  • AIMS: To discuss the clinical experiences of solid pseudopapillary tumors (SPTs) of the pancreas by summarizing clinical information of patients with this disease in China.
  • The mean diameter of the tumor was 8.4 cm (range, 2 cm-25 cm).
  • There was no significant difference in patient age and tumor size between male and female.
  • Sex, age, symptoms, tumor size and tumor markers were not significant clinical factors to predict SPTs with malignant potential.
  • Three patients developed local recurrence, and one patient developed hepatic metastasis, all within four years after tumor resection.
  • Five patients with malignant SPTs died due to tumor progression within 25 months after surgery.
  • CONCLUSIONS: Surgical resection is the most effective means for curing this rare tumor.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Child. Child, Preschool. China / epidemiology. Diagnostic Errors / prevention & control. Female. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Sex Distribution. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 18752561.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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70. Rütten A, Kutzner H, Mentzel T, Hantschke M, Eckert F, Angulo J, Rodríguez Peralto JL, Requena L: Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm. J Am Acad Dermatol; 2009 Oct;61(4):644-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm.
  • BACKGROUND: Cribriform carcinoma is the histopathologic variant of cutaneous apocrine carcinoma characterized by interconnected solid aggregations of neoplastic cells that are punctuated by small round spaces.
  • OBJECTIVE: To describe the histopathologic and immunohistochemical characteristics of this under-recognized cutaneous adnexal neoplasm.
  • Histopathologically, the neoplasms consisted of well-circumscribed dermal nodules composed of multiple, interconnected, solid aggregations of basophilic epithelial cells that were punctuated by small round spaces.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Adult. Aged. Apocrine Glands / pathology. Biopsy. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cytoplasm / pathology. Cytoplasm / ultrastructure. Diagnosis, Differential. Epithelial Cells / pathology. Epithelial Cells / ultrastructure. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Microvilli / pathology. Microvilli / ultrastructure. Middle Aged. Young Adult

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  • [CommentIn] J Am Acad Dermatol. 2011 Mar;64(3):599-601 [21315957.001]
  • (PMID = 19751882.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. López-Bonet E, Alonso-Ruano M, Barraza G, Vazquez-Martin A, Bernadó L, Menendez JA: Solid neuroendocrine breast carcinomas: incidence, clinico-pathological features and immunohistochemical profiling. Oncol Rep; 2008 Dec;20(6):1369-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid neuroendocrine breast carcinomas: incidence, clinico-pathological features and immunohistochemical profiling.
  • In 2003, the World Health Organization (WHO) classification of breast tumors definitely established that the immunohistochemical expression of NE markers in more than 50% of the tumor cell population is the unique requisite for NEBC diagnosis.
  • The criterion inclusion was the presence of more than 50% tumor immunoreactivity for one of NE markers including chromogranin, synaptophysin and CD56.
  • All the NECB were grade 2 ductal carcinoma infiltrating (DCI) with tumor sizes ranging from 7 to 55 mm.
  • These findings revealed that: a) Pure solid NEBC do not significantly differ from other breast carcinomas in terms of general clinical features;.
  • Although it remains to be elucidated whether the good prognosis of NEBC relates to the intrinsic nature of the tumor and/or to a high rate of treatment responses, their immunohistochemical profile strongly suggest that NEBC belong to the Luminal A BC subtype.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Neoplasm. Cell Differentiation. Chemotherapy, Adjuvant / methods. Female. Humans. Incidence. Middle Aged. Prognosis

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  • (PMID = 19020716.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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72. Burkadze G, Turashvili G: A case of osteoclast-like giant cell tumor of the pancreas associated with borderline mucinous cystic neoplasm. Pathol Oncol Res; 2009 Mar;15(1):129-31
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  • [Title] A case of osteoclast-like giant cell tumor of the pancreas associated with borderline mucinous cystic neoplasm.
  • An irregular solid lobulation at the lateral aspect of the cyst was visible, measuring 3 cm in the largest dimension.
  • Histologically, there were two distinct components: a mucinous, neoplastic epithelial cyst with few foci of moderate atypia, and nodular spindle cell areas containing multinucleated tumor giant cells.
  • The histological diagnosis "osteoclast-like giant cell tumor of the pancreas associated with borderline mucinous cystic neoplasm" was made.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques

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  • (PMID = 18493871.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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73. Nassar H, Qureshi H, Adsay NV, Visscher D: Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. Am J Surg Pathol; 2006 Apr;30(4):501-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas.
  • Solid papillary carcinomas (SPCs) are uncommon tumors composed of circumscribed large cellular nodules separated by bands of dense fibrosis.
  • The total size of the tumor measured 0.3 to 15 cm.
  • Axillary nodes were involved in 13% of the cases (6 of 46); all of these had an invasive component in the primary tumor.
  • Overall, 11.7% died of their tumor, 1 to 4 years after diagnosis (mean, 2.3 years); none of them belongs to the group of noninvasive SPC.
  • Five of the 6 patients who died of tumor had invasive components.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymph Node Excision. Male. Middle Aged. Mucins / metabolism. Neoplasm Invasiveness

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  • [ErratumIn] Am J Surg Pathol. 2011 Dec;35(12):1908. Volkanadsay, N [corrected to Adsay, N Volkan]
  • (PMID = 16625097.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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74. Shaikh S, Arya S, Ramadwar M, Barreto SG, Shukla PJ, Shrikhande SV: Three cases of unusual solid pseudopapillary tumors. Can radiology and histology aid decision-making? JOP; 2008;9(2):150-9
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  • [Title] Three cases of unusual solid pseudopapillary tumors. Can radiology and histology aid decision-making?
  • CONTEXT: Solid pseudopapillary tumors of the pancreas are generally considered to be of low malignant potential despite their often large size at presentation.
  • The diagnosis of a solid pseudopapillary tumor depends on the characteristic histomorphology supported by immunohistochemistry.
  • METHODS: The hospital database including the radiological records and histopathology of patients with metastatic solid pseudopapillary tumors, treated at the Tata Memorial Hospital between January 2006 and May 2007 were retrospectively reviewed.
  • RESULTS: The clinical details, radiological features and histopathology of three cases of unusually aggressive solid pseudopapillary tumors are presented.
  • CONCLUSIONS: It is important to recognize that solid pseudopapillary tumors may present or recur as locally invasive as well as widely metastatic lesions.
  • [MeSH-minor] Adult. Female. Humans. Middle Aged. Neoplasm Metastasis. Tomography, X-Ray Computed

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  • (PMID = 18326922.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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75. Kandpal H, Sharma R, Das CJ, Sahni P, Das AK, Neyaz Z: Solid pseudopapillary tumor of the pancreas with portal vein compression presenting as portal hypertension. Australas Radiol; 2007 Dec;51 Suppl:B287-91
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  • [Title] Solid pseudopapillary tumor of the pancreas with portal vein compression presenting as portal hypertension.
  • Solid pseudopapillary tumour (SPT) of the pancreas is a rare neoplasm, which occurs predominantly in young females and is usually amenable to cure by surgical resection.
  • [MeSH-minor] Adult. Constriction, Pathologic / diagnosis. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 17991087.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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76. Danzi M, Grimaldi L, Reggio S, Giordano M, Caterino M, Danzi R: [Solid pseudo papillary tumor of the pancreas: case report and literature review]. G Chir; 2008 Jun-Jul;29(6-7):271-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Solid pseudo papillary tumor of the pancreas: case report and literature review].
  • Solid pseudopapillary neoplasm (SPT) of the pancreas is a rare exocrine tumor, for the first time described from Frantz et al. in 1959.
  • Despite the increasing recognition of the tumor in this last year, its pathogenesis remain unclear.
  • [MeSH-minor] Adult. Female. Humans. Treatment Outcome

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  • (PMID = 18544263.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 19
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77. Zhao YP, Hu Y, Liao Q, Dai MH, Wu WW, Cai LX, Zhu Y: [The diagnosis and treatment of solid-pseudopapillary tumor of pancreas]. Zhonghua Wai Ke Za Zhi; 2005 Jan 1;43(1):53-5
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  • [Title] [The diagnosis and treatment of solid-pseudopapillary tumor of pancreas].
  • OBJECTIVE: To summarize the experience of diagnosis and treatment in solid-pseudopapillary tumor of pancreas (SPT).
  • The tumors of 6 cases were located in the pancreatic head, one tumor was in the neck of pancreas and 5 tumors were in the body and tail of pancreas.
  • Solid and solid-cystic masses of low echo were found in pancreas in ultrasonic examinations.
  • Tumor markers in patients' serum were all negative.
  • Simple resection of tumor was performed in 1 case.
  • CONCLUSION: Solid-pseudopapillary tumor of pancreas was one of rare pancreatic neoplasm with low malignant potential, affecting primarily young women.
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Pancreatectomy. Pancreaticoduodenectomy. Retrospective Studies. Splenectomy. Tomography, X-Ray Computed

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  • (PMID = 15774175.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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78. Miettinen M, Makhlouf HR, Sobin LH, Lasota J: Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST. Am J Surg Pathol; 2009 Nov;33(11):1624-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST.
  • A great majority of gastric mesenchymal tumors are gastrointestinal stromal tumor (GIST).
  • In this report, we describe 12 cases of a distinctive gastric tumor, named here as plexiform fibromyxoma.
  • Extramural components included subserosal nodules, and sometimes more cellular, solid nonplexiform spindle cell proliferation.
  • The tumor cells varied from oval to spindled and had limited atypia and mitotic activity < 5/50 high-power fields.
  • Immunohistochemically, the tumor cells were positive for alpha smooth muscle actin, and variably for CD10, and were consistently negative for KIT, DOG1, CD34, desmin, and S100 protein.
  • Additional 3 patients survived 14 to 25 years with unknown tumor status.
  • Plexiform fibromyxoma is a distinctive benign gastric antral neoplasm that should be separated from GIST, nerve sheath tumors, and other fibromyxoid neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19675452.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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79. Reshetov AV, Iablonskiĭ PK, Orlova RV, Markin FM, Pishchik VG: [The possibility and prognostic value of secondary lymphatic cancer spread in intrapulmonic metastases of solid tumors]. Vestn Khir Im I I Grek; 2008;167(3):36-42
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  • [Title] [The possibility and prognostic value of secondary lymphatic cancer spread in intrapulmonic metastases of solid tumors].
  • In the period from 1996 to 2007 operations were fulfilled in 120 patients with isolated pulmonary metastases of solid tumors (68 men and 52 women aged from 22 through 77 years): 46 patients with metastases of colorectal cancer, 28 - with cancer of the kidney, 23 - with non-small cell carcinoma of lung, 7 - with breast cancer, 9 - with endometrium cancer, 7 - with melanoma.
  • A conclusion is made of possible secondary lymphatic cancer spread from intrapulmonary metastases of solid tumors and its negative influence on results of treatment that allows recommendation of revision of the lymphatic system of the lungs and mediastinum in all cases of surgical treatment of intrapulmonary metastases, and in a number of cases recommendation of anatomical resections of the lung tissue as operation of choice.
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery

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  • (PMID = 18652211.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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80. Aydiner F, Erinanç H, Savaş B, Erden E, Karayalçin K: Solid pseudopapillary tumor of the pancreas: emphasis on differential diagnosis from aggressive tumors of the pancreas. Turk J Gastroenterol; 2006 Sep;17(3):219-22
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  • [Title] Solid pseudopapillary tumor of the pancreas: emphasis on differential diagnosis from aggressive tumors of the pancreas.
  • Solid pseudopapillary tumor is an unusual primary tumor of the pancreas with a low potential for malignancy and unknown cell origin, seen mostly in young women.
  • Three cases (2 female, 1 male, aged 24, 45 and 50 years, respectively) of solid pseudopapillary tumor localized in the pancreas are presented.
  • All cases displayed a well-circumscribed tumor, with an average diameter of 6 cm and a red-brown colored, hemorrhagic, cystic cut surface.
  • Microscopically they were encapsulated with large areas composed of thin papillary formations and solid areas focally.
  • Tumor cells were dyscohesive with small, round- to-oval, central nuclei, and vacuolated, clear or eosinophilic cytoplasm without mitotic activity.
  • Morphologic features of solid pseudopapillary tumor may be confused with pancreatic endocrine neoplasm and ductal adenocarcinoma.
  • We conclude that immunohistochemistry is incapable of giving additional information for the diagnosis of solid pseudopapillary tumor due to different lines of differentiation of tumor cells.
  • We believe that macroscopic and microscopic features (using hematoxylin and eosin stain) are more important for the diagnosis and differential diagnosis of this tumor.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16941259.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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81. Sievers S, Fritzsch C, Kuhnen C, Müller O: SPMSP: a solid-phase PCR with colorimetric read-out for quantitative methylation analysis. Anticancer Res; 2008 Jul-Aug;28(4B):2055-60
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  • [Title] SPMSP: a solid-phase PCR with colorimetric read-out for quantitative methylation analysis.
  • MATERIALS AND METHODS: In this work, we introduce the solid-phase methylation-specific PCR (SPMSP) as a method for quantitative methylation analysis.
  • SPMSP combines methylation-specific DNA amplification on a solid phase with subsequent colorimetric detection in an ELISA-based format.
  • [MeSH-major] Colorimetry / methods. DNA Methylation. DNA, Neoplasm / analysis. DNA, Neoplasm / genetics. Polymerase Chain Reaction / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. Colorectal Neoplasms / genetics. Humans. Middle Aged

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  • (PMID = 18751375.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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82. Camacho-Aguilera JF, Romero-Mejía C, Valenzuela-Espinoza A: Solid pseudopapillary tumor of the pancreas: case report and literature review. Cir Cir; 2010 Jan-Feb;78(1):73-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid pseudopapillary tumor of the pancreas: case report and literature review.
  • BACKGROUND: Solid pseudopapillary tumor of the pancreas is an epithelial tumor of low malignancy that primarily affects young women and represents approximately 1-2% of all pancreatic neoplasms.
  • We present a case of this type of tumor treated in the General Hospital of Tijuana, Mexico, as well as a review of the literature.
  • During open cholecystectomy we found a tumor in the body of the pancreas.
  • Biopsy was done, establishing the diagnosis of solid pseudopapillary tumor of the pancreas.
  • DISCUSSION: Solid pseudopapillary tumor of the pancreas is a rare neoplasm.
  • CONCLUSIONS: One may conclude that the solid pseudopapillary tumor is a differential diagnosis in the presence of pancreatic tumors, although due to its rarity it is not the first option to discard.
  • [MeSH-minor] Adult. Biopsy. Cholecystectomy. Cholelithiasis / complications. Cholelithiasis / surgery. Female. Humans. Incidental Findings. Pancreatectomy. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 20226131.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 39
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83. Cantley R, Gattuso P, Cimbaluk D: Solid variant of papillary renal cell carcinoma with spindle cell and tubular components. Arch Pathol Lab Med; 2010 Aug;134(8):1210-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid variant of papillary renal cell carcinoma with spindle cell and tubular components.
  • The solid variant of papillary renal cell carcinoma, when strictly defined as a tumor in which no true papillae can be identified, is extremely rare, with only a few cases reported in the literature.
  • This tumor is characterized histologically by solid sheets of cells without true papillae; nevertheless, immunohistochemical and genetic analysis supports the classification of this tumor as a variant of papillary renal cell carcinoma.
  • We report a case of solid variant of papillary renal cell carcinoma affecting a young man and provide histologic and clinical follow-up data, adding an additional case of this extremely rare pathology to the literature.
  • In addition, we describe the first case, to our knowledge, of a solid variant of papillary renal cell carcinoma to contain a high-grade (sarcomatoid) spindle cell component.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Chromosomes, Human, Pair 17. DNA, Neoplasm / analysis. Disease-Free Survival. Humans. In Situ Hybridization, Fluorescence. Male. Nephrectomy. Treatment Outcome. Trisomy

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  • (PMID = 20670145.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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84. Yoshida A, Sen C, Asa SL, Rosenblum MK: Composite pituitary adenoma and craniopharyngioma?: an unusual sellar neoplasm with divergent differentiation. Am J Surg Pathol; 2008 Nov;32(11):1736-41
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  • [Title] Composite pituitary adenoma and craniopharyngioma?: an unusual sellar neoplasm with divergent differentiation.
  • We report a young man who presented with atrial fibrillation and was subsequently found to have a markedly elevated serum thyroid stimulating hormone level and a solid, noncalcified intrasellar mass on imaging.
  • The patient was treated with thyroid radioablation and hormone replacement and followed for 7 years, during which time the tumor grew to 4.6 cm.
  • At transsphenoidal surgery, a tumor consisting of a pituitary adenoma and adamantinomatous craniopharyngiomalike components was resected.
  • This lesion may represent an unusual composite tumor attributable to divergent differentiation of a common precursor.
  • [MeSH-minor] Adult. Atrial Fibrillation / etiology. Humans. Hyperthyroidism / etiology. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Thyrotropin / secretion

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  • (PMID = 18769335.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin
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85. Kallichanda N, Tsai S, Stabile BE, Buslon V, Delgado DL, French SW: Histogenesis of solid pseudopapillary tumor of the pancreas: the case for the centroacinar cell of origin. Exp Mol Pathol; 2006 Oct;81(2):101-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histogenesis of solid pseudopapillary tumor of the pancreas: the case for the centroacinar cell of origin.
  • Solid pseudopapillary tumor (SPT) is an unusual pancreatic neoplasm of low malignant potential that most frequently occurs in young women.
  • The tumor is indolent, with long patient survival, even in the presence of extension into adjacent organs and metastases.
  • Histologically, it is a solid and cystic tumor with a prominent vascular network and degenerative pseudopapillae formation.
  • Herein, we report a case of solid pseudopapillary tumor in a 41-year-old female in which the tumor cells immunohistochemically and ultrastructurally suggest a centroacinar cell origin.
  • The tumor cells and the normal centroacinar cells stained positive for alpha-antitrypsin (alpha-AT), CD10, cyclin D1 and NSE.
  • [MeSH-minor] Adult. Cyclin D1 / analysis. Female. Humans. Neprilysin / analysis. Phosphopyruvate Hydratase / analysis. alpha 1-Antitrypsin / analysis

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  • (PMID = 16916512.001).
  • [ISSN] 0014-4800
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / P50-019991
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha 1-Antitrypsin; 136601-57-5 / Cyclin D1; EC 3.4.24.11 / Neprilysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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86. Chen SQ, Zou SQ, Dai QB, Li H: Clinical analysis of solid-pseudopapillary tumor of the pancreas: report of 15 cases. Hepatobiliary Pancreat Dis Int; 2008 Apr;7(2):196-200
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  • [Title] Clinical analysis of solid-pseudopapillary tumor of the pancreas: report of 15 cases.
  • BACKGROUND: Solid-pseudopapillary tumor of the pancreas (SPTP) is an uncommon and enigmatic pancreatic neoplasm that occurs mainly in young women.
  • This study was designed to stimulate consideration of this tumor.
  • Almost all SPTPs demonstrated a solid structure with hypo- or iso-attenuation, cystic structure with hypo-attenuation on pre-contrast CT scan, and enhancement of solid portions on post-contrast CT scan.
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pancreatectomy / methods. Prognosis. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 18397858.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] China
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87. Watanabe D, Miura K, Goto T, Nanjo H, Yamamoto Y, Ohnishi H: Solid pseudopapillary tumor of the pancreas with concomitant pancreas divisum. A case report. JOP; 2010;11(1):45-8
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  • [Title] Solid pseudopapillary tumor of the pancreas with concomitant pancreas divisum. A case report.
  • CONTEXT: Solid pseudopapillary tumor of the pancreas is a rare neoplasm which affects young women.
  • Here, we report a case of a solid pseudopapillary tumor of the pancreas with concomitant pancreas divisum.
  • CASE REPORT: A 26-year-old woman was diagnosed as having a pancreatic tumor with solid and cystic components in the pancreatic head.
  • Microscopically, the resected tumor had solid and cystic components.
  • Immunohistochemical study demonstrated that the tumor cells were positive for alpha-1-antitrypsine, vimentin and progesterone receptors but negative for estrogen receptors, NSE, insulin or glucagon.
  • The tumor was diagnosed as a solid pseudopapillary tumor of the pancreas.
  • Although more than 700 cases of solid pseudopapillary tumors of the pancreas have been reported in the English literature, a search of PubMed turned up no reports of concomitant solid pseudopapillary tumor and pancreas divisum.
  • CONCLUSION: Solid pseudopapillary tumors of the pancreas with concomitant pancreas divisum are extremely rare.
  • [MeSH-minor] Adult. Female. Humans. Pancreatic Diseases / complications. Pancreatic Diseases / congenital. Pancreatic Diseases / diagnosis

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  • (PMID = 20065552.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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88. Go JH: A spindle cell predominant pancreatic solid-pseudopapillary tumor. Yonsei Med J; 2008 Aug 30;49(4):672-5
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  • [Title] A spindle cell predominant pancreatic solid-pseudopapillary tumor.
  • A hitherto unrecognized variant of solid-pseudopapillary tumor (SPT) of the pancreas is reported.
  • The tumor presented in the pancreatic tail of a 44-year-old female patient.
  • It was a well-defined, solid nodule measuring 25 mm in diameter, with homogenous tan gray cut surface.
  • Histologically, the neoplasm was mostly composed of sheets of spindle cells.
  • The periphery of the tumor showed typical feature of SPT.
  • Immunohistochemically, the tumor cells were positive for vimentin, CD10, CD56, beta-catenin, and alpha1-antichymotrypsin, but negative for cytokeratin, chromogranin, synaptophysin and S-100 protein.
  • Ultrastructurally, the tumor showed a few acinar spaces with microvilli between tumor cells.
  • This case is peculiar in that the tumor did not show gross cystic change and predominantly consists of spindle shaped tumor cells, so may cause difficult diagnostic problem.
  • [MeSH-minor] Adult. Female. Humans

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  • [Cites] Am J Surg Pathol. 2000 Oct;24(10):1361-71 [11023097.001]
  • [Cites] Am J Surg Pathol. 2002 Jun;26(6):818-20 [12023593.001]
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  • (PMID = 18729314.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2615298
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89. Paulino AC, Fowler BZ: Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol; 2005 Mar;22(2):89-101
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  • [Title] Secondary neoplasms after radiotherapy for a childhood solid tumor.
  • This study was conducted to determine the outcome of patients who develop a second neoplasm after radiotherapy (RT) for a childhood solid tumor.
  • From 1956 to 1998, 429 children with a malignant solid tumor were treated at a single radiation oncology facility.
  • The medical records and radiotherapy charts were reviewed to determine if the patient developed a secondary neoplasm after treatment for malignancy.
  • Twenty-three (5.4%) patients developed a secondary neoplasm.
  • The types of initial solid tumors treated with RT were Ewing sarcoma in 6, Wilms tumor in 6, medulloblastoma in 5, neuroblastoma in 3, and other in 3.
  • For the 14 malignant neoplasms, the median time interval from initial tumor to second malignancy was 10.1 years.
  • The 14 benign neoplasms appeared at a median time of 16.9 years and included cervical intraepithelial neoplasia in 3, osteochondroma in 3, thyroid adenoma in 1, duodenal adenoma in 1, lipoma in 1, cherry angioma in 1, uterine leiomyoma in 1, ovarian cystadenofibroma in 1, and giant cell tumor in 1.
  • [MeSH-minor] Adolescent. Adult. Cause of Death. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Radiation Dosage. Retrospective Studies. Survival Rate

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  • (PMID = 15804994.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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90. Jacobs JF, Brasseur F, Hulsbergen-van de Kaa CA, van de Rakt MW, Figdor CG, Adema GJ, Hoogerbrugge PM, Coulie PG, de Vries IJ: Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR. Int J Cancer; 2007 Jan 1;120(1):67-74
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  • [Title] Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR.
  • We measured the levels of expression of 12 CGGs in various pediatric solid tumors to identify targets for therapeutic cancer vaccines.
  • Pediatric solid tumors express several CGGs, which encode antigens that could be targeted in therapeutic vaccination trials.
  • [MeSH-major] Antigens, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Neoplasm Proteins / genetics. Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / genetics. Bone Neoplasms / metabolism. Child. Child, Preschool. Humans. Immunoenzyme Techniques. Infant. Infant, Newborn. Male. Membrane Proteins / genetics. Membrane Proteins / metabolism. Neuroblastoma / genetics. Neuroblastoma / metabolism. Osteosarcoma / genetics. Osteosarcoma / metabolism. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Rhabdomyosarcoma / genetics. Rhabdomyosarcoma / metabolism. Sarcoma, Ewing / genetics. Sarcoma, Ewing / metabolism. Testis / metabolism

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  • (PMID = 17019710.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / GAGE2A protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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91. Dummer R, Rochlitz C, Velu T, Acres B, Limacher JM, Bleuzen P, Lacoste G, Slos P, Romero P, Urosevic M: Intralesional adenovirus-mediated interleukin-2 gene transfer for advanced solid cancers and melanoma. Mol Ther; 2008 May;16(5):985-94
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  • [Title] Intralesional adenovirus-mediated interleukin-2 gene transfer for advanced solid cancers and melanoma.
  • We have conducted a phase I/II, multicenter, open-label, dose-escalating study to evaluate the safety, efficacy, and biological effects of repeated intratumoral injections of adenovirus-IL-2 (TG1024) in patients with advanced solid tumors and melanoma.
  • Thirty five patients (twenty-five with metastatic melanoma and ten with other solid tumors) were treated in eight successive cohorts at dose levels ranging from 3 x 10(8) to 3 x 10(11) viral particles (vp).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / therapy. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 18388930.001).
  • [ISSN] 1525-0024
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-2; 7GR28W0FJI / Dacarbazine
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92. Barbot AC, Mussault P, Ingrand P, Tourani JM: Assessing 2-month clinical prognosis in hospitalized patients with advanced solid tumors. J Clin Oncol; 2008 May 20;26(15):2538-43

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  • [Title] Assessing 2-month clinical prognosis in hospitalized patients with advanced solid tumors.
  • PURPOSE: The aim of this study was to assess clinical, laboratory, and subjective (patient's preferences) prognostic factors in hospitalized patients with advanced solid tumors.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Health Surveys. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis. Prospective Studies. Risk Factors. Survival Rate. Time Factors

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  • (PMID = 18487571.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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93. Campara M, Tzvetanov IG, Oberholzer J: Interleukin-2 receptor blockade with humanized monoclonal antibody for solid organ transplantation. Expert Opin Biol Ther; 2010 Jun;10(6):959-69
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  • [Title] Interleukin-2 receptor blockade with humanized monoclonal antibody for solid organ transplantation.
  • AREAS COVERED IN THIS REVIEW: This review will update the reader on recently published daclizumab studies in adult solid organ transplant recipients, focusing on comparative studies with other induction agents.
  • [MeSH-minor] Animals. Antibodies, Monoclonal, Humanized. Antibodies, Neoplasm / therapeutic use. Heart Transplantation / immunology. Humans. Immunoglobulin G / therapeutic use. Intestines / transplantation. Kidney Transplantation / immunology. Liver Transplantation / immunology. Lung Transplantation / immunology. Recombinant Fusion Proteins / therapeutic use

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  • (PMID = 20415630.001).
  • [ISSN] 1744-7682
  • [Journal-full-title] Expert opinion on biological therapy
  • [ISO-abbreviation] Expert Opin Biol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antibodies, Neoplasm; 0 / Immunoglobulin G; 0 / Immunosuppressive Agents; 0 / Receptors, Interleukin-2; 0 / Recombinant Fusion Proteins; 0 / basiliximab; 3A189DH42V / alemtuzumab; CUJ2MVI71Y / daclizumab
  • [Number-of-references] 49
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94. Fusaroli P, Spada A, Mancino MG, Caletti G: Contrast harmonic echo-endoscopic ultrasound improves accuracy in diagnosis of solid pancreatic masses. Clin Gastroenterol Hepatol; 2010 Jul;8(7):629-34.e1-2
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  • [Title] Contrast harmonic echo-endoscopic ultrasound improves accuracy in diagnosis of solid pancreatic masses.
  • We assessed whether CHE-EUS increases the accuracy of diagnosis of pancreatic solid lesions.
  • METHODS: At a tertiary-care EUS center, we examined 90 patients who were suspected of having pancreatic solid neoplasm.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Animals. Biopsy, Fine-Needle. Female. Histocytochemistry. Humans. Male. Middle Aged

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  • [Copyright] Copyright (c) 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20417721.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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95. Kim SH, Cho YT, Kwon HJ, An CM, Kim IH, Kim SW, Lee ST, Lee SO: [A case of atypical Solid-pseudopapillary tumor of the pancreas]. Korean J Gastroenterol; 2009 Oct;54(4):252-6
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  • [Title] [A case of atypical Solid-pseudopapillary tumor of the pancreas].
  • Solid-psudopapillary tumor is an uncommon pancreatic neoplasm of low malignant potential that most frequently affect young woman.
  • Solid-psudopapillary tumor are histologically, clinically, and prognostically quite distinct from the more common ductal adenocarcinoma.
  • Recently, we experienced a 36-year-old male who was suspected to have extrapancreatic tumor based on atypical radiologic imaging study, young age, and male sex, and finally diagnosed as solid-psudopapillary tumor on immunohistochemical stain examination.
  • [MeSH-minor] Adult. Antigens, CD56 / metabolism. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Humans. Male. Neprilysin / metabolism. Tomography, X-Ray Computed. Vimentin / metabolism

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  • (PMID = 19844146.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Vimentin; EC 3.4.24.11 / Neprilysin
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96. Mita M, Mita A, Sarantopoulos J, Takimoto CH, Rowinsky EK, Romero O, Angiuli P, Allievi C, Eisenfeld A, Verschraegen CF: Phase I study of paclitaxel poliglumex administered weekly for patients with advanced solid malignancies. Cancer Chemother Pharmacol; 2009 Jul;64(2):287-95
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  • [Title] Phase I study of paclitaxel poliglumex administered weekly for patients with advanced solid malignancies.
  • This study was designed to determine the MTD and pharmacology of PPX administered weekly to patients with solid malignancies.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Drug Resistance, Neoplasm. Female. Humans. Male. Maximum Tolerated Dose. Middle Aged. Neoplasm Staging. Prognosis. Salvage Therapy. Survival Rate. Treatment Outcome

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  • (PMID = 19034451.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / paclitaxel poliglumex; 25513-46-6 / Polyglutamic Acid; P88XT4IS4D / Paclitaxel
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97. Demetri GD, Lo Russo P, MacPherson IR, Wang D, Morgan JA, Brunton VG, Paliwal P, Agrawal S, Voi M, Evans TR: Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors. Clin Cancer Res; 2009 Oct 1;15(19):6232-40
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  • [Title] Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors.
  • PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and recommended phase II dose of dasatinib in metastatic solid tumors refractory to standard therapies or for which no effective standard therapy exists.
  • Although no objective tumor responses were seen, durable stable disease was observed in 16% of patients.
  • Doses of 120 mg twice daily (5D2) or 70 mg twice daily (CDD) are recommended for further studies in patients with solid tumors.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / adverse effects. Antineoplastic Agents / pharmacokinetics. Dasatinib. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Resistance, Neoplasm / drug effects. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19789325.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Pyrimidines; 0 / Thiazoles; RBZ1571X5H / Dasatinib
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98. Bostanoglu S, Otan E, Akturan S, Hamamci EO, Bostanoglu A, Gokce A, Albayrak L: Frantz's tumor (solid pseudopapillary tumor) of the pancreas. A case report. JOP; 2009;10(2):209-11
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  • [Title] Frantz's tumor (solid pseudopapillary tumor) of the pancreas. A case report.
  • CONTEXT: A solid pseudopapillary tumor of the pancreas is a rare neoplasm which, for the most part, affects young women and has a relatively favorable prognosis with a low malignant potential.
  • CASE REPORT: We report the case of a 29-year-old woman who underwent complete resection of the tumor using a distal pancreatectomy and splenectomy procedure.
  • CONCLUSIONS: A solid pseudopapillary tumor of the pancreas is a rare condition with a low potential for malignancy and favorable prognosis; surgical resection is generally curative.
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Pancreatectomy / methods. Prognosis. Splenectomy / methods. Treatment Outcome

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  • (PMID = 19287121.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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99. Busca A, Novarino A, de Fabritiis P, Picardi A, Zeuli M, Locatelli F, Bertetto O, Falda M: Nonmyeloablative allogeneic blood stem cell transplantation in patients with metastatic solid tumors. Hematology; 2006 Jun;11(3):171-7
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  • [Title] Nonmyeloablative allogeneic blood stem cell transplantation in patients with metastatic solid tumors.
  • BACKGROUND: The aim of the study was to evaluate the feasibility and efficacy of a non-myeloablative regimen to achieve complete donor chimerism after stem cell transplantation (SCT) in patients with metastatic solid tumors.
  • Regression of tumor metastases has been observed in 1 patient with RCC.
  • CONCLUSIONS: Our preliminary results suggest that non-myeloablative SCT for metastatic solid tumors is feasible, although may lead to durable responses in a minority of patients.
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Feasibility Studies. Female. Graft Survival. Graft vs Host Disease / epidemiology. Graft vs Host Disease / etiology. Graft vs Host Disease / prevention & control. Graft vs Tumor Effect. Humans. Immunosuppressive Agents / therapeutic use. Kidney Neoplasms / surgery. Male. Middle Aged. Neoplasm Metastasis. Postoperative Complications. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery. Sarcoma / secondary. Sarcoma / surgery. Survival Analysis. Transplantation, Homologous / adverse effects. Transplantation, Homologous / statistics & numerical data

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  • (PMID = 17325957.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; FA2DM6879K / Vidarabine; P2K93U8740 / fludarabine
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100. Troisi R, Montalti R, Smeets P, Van Huysse J, Van Vlierberghe H, Colle I, De Gendt S, de Hemptinne B: The value of laparoscopic liver surgery for solid benign hepatic tumors. Surg Endosc; 2008 Jan;22(1):38-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of laparoscopic liver surgery for solid benign hepatic tumors.
  • The indication was solid benign liver tumor in 56 (8.9%) patients.
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Laparotomy / adverse effects. Laparotomy / methods. Length of Stay. Male. Middle Aged. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Pain, Postoperative / physiopathology. Probability. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • (PMID = 17705077.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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