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1. Aulmann S, Longerich T, Schirmacher P, Mechtersheimer G, Penzel R: Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. Histopathology; 2007 Jun;50(7):881-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.
  • AIMS: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, non-reciprocal translocation der(17)t(X;17)(p11.2;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TFE3.
  • The aim of this study was to analyse the chromosomal breakpoints in paraffin-embedded tissue.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Neoplasm Proteins / genetics. Oncogene Fusion. Oncogene Proteins, Fusion / genetics. Sarcoma, Alveolar Soft Part / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Child, Preschool. Chromosomes, Human, Pair 17. Chromosomes, Human, X. DNA, Neoplasm / analysis. Female. Humans. In Situ Hybridization, Fluorescence. Male

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  • (PMID = 17543078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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2. Lin J, Wang J, Yu LJ, Ying XL: [Low-grade fibromyxoid sarcoma: a clinicopathological analysis of 9 cases]. Zhonghua Bing Li Xue Za Zhi; 2009 May;38(5):302-6
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  • [Title] [Low-grade fibromyxoid sarcoma: a clinicopathological analysis of 9 cases].
  • OBJECTIVE: To study the clinicopathological features, immnophenotype and differential diagnosis of low-grade fibromyxoid sarcoma (LGFMS).
  • Three cases presented with recurrent diseases after incomplete resection.
  • CONCLUSIONS: LGFMS is a distinctive low grade fibroblastic sarcoma of young adults.
  • [MeSH-major] Extremities / pathology. Fibrosarcoma / pathology. Soft Tissue Neoplasms / pathology. Vimentin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Diagnosis, Differential. Female. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Myxosarcoma / pathology. Young Adult

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  • (PMID = 19575871.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Vimentin
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3. Jameel A, Jamil SN: Safety of cytotoxic chemotherapy during pregnancy. J Pak Med Assoc; 2007 Sep;57(9):449-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Six patients (33%) had breast cancer, four (22%) had chronic myeloid leukaemia, two (11%) had Hodgkin's disease, two (11%) had acute myeloid leukaemia and one each had recurrent ovarian carcinoma (5.7%), soft-tissue sarcoma (5.7%), acute lymphoblastic leukaemia (5.7%) and non-Hodgkin's lymphoma (5.7%).
  • [MeSH-minor] Adult. Breast Neoplasms / drug therapy. Female. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Neoplasms / drug therapy. Pregnancy. Pregnancy Trimester, Second. Prospective Studies. Time Factors

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  • (PMID = 18072640.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cytotoxins
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4. Nilbert M, Therkildsen C, Nissen A, Akerman M, Bernstein I: Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrum. Fam Cancer; 2009;8(3):209-13
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  • The median age at sarcoma diagnosis was 43 (15-74) years.
  • Soft tissue sarcomas predominated followed by uterine sarcomas and eight histopathological subtypes were represented with recurrent diagnoses of liposarcoma, leiomyosarcoma, and carcinosarcoma.
  • Tumor tissue from eight cases was available for analysis of mismatch-repair (MMR) status using immunohistochemical staining and analysis of microsatellite instability, which revealed MMR defects in six of the eight tumors investigated.
  • This suggests that sarcomas may be part of the HNPCC tumor spectrum and that colorectal cancer should be considered in the family history of sarcoma patients.
  • [MeSH-major] Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. MutS Homolog 2 Protein / genetics. Sarcoma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Colorectal Neoplasms / genetics. DNA Mismatch Repair. DNA Repair Enzymes / genetics. DNA-Binding Proteins / genetics. Endometrial Neoplasms / genetics. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19130300.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; EC 3.6.1.3 / MutS Homolog 2 Protein; EC 6.5.1.- / DNA Repair Enzymes
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5. Raney RB: Synovial sarcoma in young people: background, prognostic factors, and therapeutic questions. J Pediatr Hematol Oncol; 2005 Apr;27(4):207-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma in young people: background, prognostic factors, and therapeutic questions.
  • Synovial sarcoma represents 5% to 10% of all soft tissue sarcomas, with an estimated total of 800 new cases annually in the United States.
  • Anderson Cancer Center's Division of Pediatrics, St. Jude Children's Research Hospital, the German Cooperative Group, and Istituto Nazionale dei Tumori, Milan, found that, as in older people, tumor size larger than 5 cm, residual local tumor or metastases at diagnosis, and progressive or recurrent disease all portended a poor outcome.
  • There are currently no randomized studies of therapy for patients with synovial sarcoma, but such are needed to provide answers to the following questions: Is adjuvant chemotherapy useful in preventing recurrence in patients without visible residual disease after apparently complete surgical removal of localized tumor?
  • [MeSH-major] Sarcoma, Synovial / pathology. Sarcoma, Synovial / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Infant. Male. Neoplasm Recurrence, Local / pathology. Prognosis. Risk Factors. Survival Rate. Treatment Outcome

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  • (PMID = 15838392.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Kneser U, Bach AD, Polykandriotis E, Kopp J, Horch RE: Delayed reverse sural flap for staged reconstruction of the foot and lower leg. Plast Reconstr Surg; 2005 Dec;116(7):1910-7
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  • BACKGROUND: Soft-tissue defects of the foot and lower leg caused by traumatic injury, tumor ablation, or infection associated with osteomyelitis often require coverage by flaps.
  • METHODS: The authors successfully used delayed sural flaps based on a two-step procedure for the treatment of 11 patients (three women and eight men, age 50.1 +/- 20.0 years) with osteomyelitis (n = 3), melanoma (n = 3), sarcoma (n = 1), squamous cell carcinoma (n = 1), posttraumatic defects (n = 2), and recurrent gouty ulcer (n = 1).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Debridement. Female. Heel / surgery. Humans. Male. Middle Aged. Skin Transplantation. Soft Tissue Injuries / surgery. Time Factors

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  • [CommentIn] Plast Reconstr Surg. 2006 Aug;118(2):571-2 [16874261.001]
  • [CommentIn] Plast Reconstr Surg. 2006 Aug;118(2):572; author reply 572-3 [16874263.001]
  • (PMID = 16327603.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Riedel K, Kremer T, Hoffmann H, Pfannschmidt J, Reimer P, Dienemann H, Germann G, Sauerbier M: [Plastic surgical reconstruction of extensive thoracic wall defects after oncologic resection]. Chirurg; 2008 Feb;79(2):164-74
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  • In defect reconstruction following radical oncologic resection of malignant chest wall tumors, adequate soft-tissue reconstruction must be achieved along with function, stability, integrity, and aesthetics of the chest wall.
  • Indications were locally recurrent breast carcinoma (patient n=22), thymoma (n=1), and desmoid tumor (n=1).
  • Primary lesions of the chest wall were spinalioma (n=1), sarcoma (n=7), and non-small-cell lung cancer (n=2).
  • Soft-tissue reconstruction was carried out using primary closure (n=1), external oblique flap (n=1), pectoralis major myocutaneous flap (n=3), latissimus dorsi myocutaneous flap (n=18), vertical or transversal rectus abdominis myocutaneous flap (n=9), free tensor fascia lata- flap (n=6), trapezius flap (n=1), serratus flap (n=1), and one filet flap.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Patient Care Team. Postoperative Complications / etiology. Reoperation. Ribs / surgery. Surgical Mesh. Wound Healing / physiology

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  • (PMID = 17786394.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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8. Chukwuanukwu TO, Anyanwu SN: Giant fibrosarcoma prostuberans of abodominal wall: management problems in resources-constrained country. Niger J Clin Pract; 2009 Sep;12(3):338-40
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  • BACKGROUND: Abdominal wall sarcomas represent less than 1% of adult malignancies.
  • METHODS: Prospective study of patients with abdominal wall soft tissue sarcoma presenting to the authors.
  • Three presented with recurrent fungating masses.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Nigeria. Surgical Mesh

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  • (PMID = 19803041.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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9. Blay JY, von Mehren M, Samuels BL, Fanucchi MP, Ray-Coquard I, Buckley B, Gilles L, Lebedinsky C, Elsayed YA, Le Cesne A: Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma. Clin Cancer Res; 2008 Oct 15;14(20):6656-62
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  • [Title] Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma.
  • PURPOSE: To determine the dose of trabectedin plus doxorubicin with granulocyte colony-stimulating factor support associated with manageable neutropenia and acceptable dose-limiting toxicities (DLT) in patients with recurrent or persistent soft-tissue sarcoma.
  • CONCLUSION: The combination of doxorubicin 60 mg/m(2) followed by trabectedin 1.1 mg/m(2) every 21 days is safe and active in patients with soft-tissue sarcoma.

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  • (PMID = 18927308.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA006927; None / None / / P30 CA006927-46; United States / NCI NIH HHS / CA / P30 CA006927-46
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dioxoles; 0 / Tetrahydroisoquinolines; 114899-77-3 / trabectedin; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 80168379AG / Doxorubicin
  • [Other-IDs] NLM/ NIHMS113333; NLM/ PMC2777645
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10. Wong CH, Tan BK, Koong HN, Lim CH, Chia SJ, Song C: Use of the omentum flap as additional soft-tissue cover for abdominal wall defects reconstructed with Gore-Tex. Plast Reconstr Surg; 2005 Nov;116(6):1715-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of the omentum flap as additional soft-tissue cover for abdominal wall defects reconstructed with Gore-Tex.
  • These defects resulted from tumor resection and recurrent incisional hernia.
  • CONCLUSION: The omentum flap served as an additional soft-tissue cover over the Gore-Tex repair to prevent exposure in the event of infection or flap breakdown.
  • [MeSH-minor] Adult. Female. Hernia, Abdominal / surgery. Humans. Male. Muscle Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Omentum. Prosthesis-Related Infections / surgery. Recurrence. Sarcoma / surgery. Surgical Flaps. Wound Healing

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  • [CommentIn] Plast Reconstr Surg. 2006 Jan;117(1):312-3 [16404285.001]
  • (PMID = 16267436.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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11. Lazzaro G, Lazzari R, Pelosi G, De Pas T, Mariani L, Mazzarol G, Sances D, Tosti G, Baldini F, Mosconi M, Tedeschi I, Viale G, Marsiglia H, Chiappa A, Vavassori A, Orecchia R, Testori A: Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk. Ann Surg Oncol; 2005 Nov;12(11):935-42
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  • [Title] Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk.
  • BACKGROUND: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment.
  • METHODS: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8).
  • CONCLUSIONS: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.
  • [MeSH-major] Brachytherapy. Extremities. Muscle, Skeletal. Sarcoma / radiotherapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Radiotherapy Dosage. Radiotherapy, Adjuvant / adverse effects. Radiotherapy, Adjuvant / utilization. Survival Rate

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  • (PMID = 16195832.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Lashkari A, Chow WA, Valdes F, Leong L, Phan V, Twardowski P, Kapoor N, Molina A, Al-Kadhimi Z, Frankel P, Somlo G: Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma. Anticancer Res; 2009 Aug;29(8):3281-8
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  • [Title] Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma.
  • BACKGROUND: Patients with locally advanced or metastatic/recurrent soft tissue and Ewing's sarcoma (EWS) have few treatment options.
  • CONCLUSION: Our study demonstrates the feasibility and safety of tandem HDCT in patients with high-risk or metastatic/recurrent sarcoma, with some patients achieving long-term PFS and OS.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / therapy. Hematopoietic Stem Cell Transplantation. Neoplasm Recurrence, Local / therapy. Sarcoma / therapy
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Combined Modality Therapy. Disease Progression. Doxorubicin / administration & dosage. Feasibility Studies. Female. Humans. Ifosfamide / administration & dosage. Immunoenzyme Techniques. Male. Melphalan / administration & dosage. Mesna / administration & dosage. Neoplasm Staging. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Neuroectodermal Tumors, Primitive, Peripheral / therapy. Osteosarcoma / pathology. Osteosarcoma / therapy. Prognosis. Prospective Studies. Protective Agents / administration & dosage. Remission Induction. Rhabdomyosarcoma / pathology. Rhabdomyosarcoma / therapy. Safety. Sarcoma, Ewing / pathology. Sarcoma, Ewing / therapy. Survival Rate. Transplantation, Autologous. Treatment Outcome. Young Adult

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  • (PMID = 19661346.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Protective Agents; 80168379AG / Doxorubicin; NR7O1405Q9 / Mesna; Q20Q21Q62J / Cisplatin; Q41OR9510P / Melphalan; UM20QQM95Y / Ifosfamide
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13. Di Filippo F, Giacomini P, Rossi CR, Santinami M, Garinei R, Anzà M, Deraco M, Botti C, Perri P, Cavaliere F, Di Angelo P, Sofra C, Sperduti I, Pasqualoni R, Di Filippo S, Corrias F, Armenti A, Ferraresi V: Hyperthermic isolated perfusion with tumor necrosis factor-alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcoma: the experience of the Italian Society of Integrated Locoregional Treatment in Oncology (SITILO). In Vivo; 2009 Mar-Apr;23(2):363-7
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  • [Title] Hyperthermic isolated perfusion with tumor necrosis factor-alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcoma: the experience of the Italian Society of Integrated Locoregional Treatment in Oncology (SITILO).
  • BACKGROUND: Tumor necrosis factor-alpha (TNFalpha)-based hyperthermic isolated limb perfusion (HILP) is routinely carried out at most oncological institutions in the treatment of locally advanced soft tissue limb sarcoma (STS), employing high TNFalpha dosages.
  • PATIENTS AND METHODS: HILP with TNFalpha (at a dosage of either <or=1 mg or >1 mg) and Dx was administered to 75 patients with limb-threatening STS: 37 males and 38 females; median age 50 years; tumor in the lower and upper limbs in 58 and 17 patients, respectively; primary and recurrent tumors in 45 and 30 patients, respectively.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Doxorubicin / administration & dosage. Hyperthermia, Induced. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy. Tumor Necrosis Factor-alpha / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Cancer, Regional Perfusion / methods. Disease-Free Survival. Extremities / pathology. Female. Humans. Male. Middle Aged. Perfusion. Recurrence. Treatment Outcome

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  • (PMID = 19414428.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; 80168379AG / Doxorubicin
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14. Puhaindran ME, Steensma MR, Athanasian EA: Partial hand preservation for large soft tissue sarcomas of the hand. J Hand Surg Am; 2010 Feb;35(2):291-5
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  • [Title] Partial hand preservation for large soft tissue sarcomas of the hand.
  • In patients with large soft tissue sarcomas of the hand, partial hand preservation is extremely challenging for surgeons attempting a complete resection of the tumor with negative resection margins.
  • We conducted this review to examine the oncologic outcome, including local recurrence rate and patient overall survival, and functional outcome after resections for large soft tissue sarcomas with partial hand preservation.
  • METHODS: We performed a retrospective review of all patients with soft tissue sarcomas of the hand treated at our institution from 1995 to 2007.
  • Two patients had myxofibrosarcoma, 2 patients had synovial sarcoma, 2 patients had malignant fibrous histiocytoma, 1 patient had a malignant peripheral nerve sheath tumor, and 1 patient had a liposarcoma.
  • RESULTS: Of the 8 patients, 1 died of distant metastatic disease, 1 developed local tumor recurrence and is alive with locally recurrent disease, and the other 6 patients are completely disease-free.
  • CONCLUSIONS: Partial hand preservation is possible in selected patients with large soft tissue sarcomas of the hand, obtaining low local recurrence rates, good overall survival, and good functional outcome.
  • [MeSH-major] Hand / surgery. Limb Salvage / methods. Neoplasm Recurrence, Local / pathology. Sarcoma / diagnosis. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Amputation / methods. Arm. Artificial Limbs. Child. Cohort Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prosthesis Fitting. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2010 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20141899.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Pawlik TM, Pisters PW, Mikula L, Feig BW, Hunt KK, Cormier JN, Ballo MT, Catton CN, Jones JJ, O'Sullivan B, Pollock RE, Swallow CJ: Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma. Ann Surg Oncol; 2006 Apr;13(4):508-17
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  • [Title] Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma.
  • BACKGROUND: The reported data on surgery plus radiotherapy for retroperitoneal soft tissue sarcomas (RPS) have been mostly from retrospective studies.
  • Fifty-four patients (75%) had primary RPS, whereas 18 (25%) had recurrent disease.
  • [MeSH-major] Neoplasm Recurrence, Local. Preoperative Care. Retroperitoneal Space. Sarcoma / radiotherapy. Sarcoma / surgery. Soft Tissue Neoplasms / radiotherapy. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Survival Analysis

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  • [CommentIn] Ann Surg Oncol. 2006 Apr;13(4):442-3 [16511670.001]
  • (PMID = 16491338.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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16. Brady MS, Brown K, Patel A, Fisher C, Marx W: Isolated limb infusion with melphalan and dactinomycin for regional melanoma and soft-tissue sarcoma of the extremity: final report of a phase II clinical trial. Melanoma Res; 2009 Apr;19(2):106-11
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  • [Title] Isolated limb infusion with melphalan and dactinomycin for regional melanoma and soft-tissue sarcoma of the extremity: final report of a phase II clinical trial.
  • Isolated limb infusion (ILI) is a minimally invasive technique of delivering regional chemotherapy in patients with advanced melanoma or soft-tissue sarcoma of the limb.
  • Eligible patients had recurrent melanoma or unresectable soft-tissue sarcoma of the limb.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Chemotherapy, Cancer, Regional Perfusion. Extremities. Melanoma / drug therapy. Sarcoma / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anesthesia, General. Brachial Artery. Catheterization, Peripheral. Dactinomycin / administration & dosage. Female. Humans. Infusions, Intra-Arterial. Male. Melphalan / administration & dosage. Middle Aged. Popliteal Artery. Radiography, Interventional. Remission Induction


17. Hajdu M, Singer S, Maki RG, Schwartz GK, Keohan ML, Antonescu CR: IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting. J Pathol; 2010 Jul;221(3):300-7
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  • The pathogenesis driving this neoplasm remains unclear, with no recurrent genetic aberrations described to date.
  • The transcriptional signature was compared to a set of 34 soft tissue sarcomas spanning seven subtypes.
  • SFT had a distinct expression signature and clustered in a tight genomic cluster, separate from all other sarcoma subtypes.

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  • [Copyright] (c) 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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  • (PMID = 20527023.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA148260; United States / NCI NIH HHS / CA / P01CA47179; United States / NCI NIH HHS / CA / RC2 CA148260-01; United States / NCI NIH HHS / CA / RC2 CA148260; United States / NCI NIH HHS / CA / P01 CA047179-18; United States / CCR NIH HHS / RC / CA148260-01; United States / NCI NIH HHS / CA / P01 CA047179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / FGFR1OP protein, human; 0 / IGF2 protein, human; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; 67763-97-7 / Insulin-Like Growth Factor II; EC 2.7.10.1 / DDR1 protein, human; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ NIHMS349582; NLM/ PMC3264680
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18. Hui AC, Ngan SY, Wong K, Powell G, Choong PF: Preoperative radiotherapy for soft tissue sarcoma: the Peter MacCallum Cancer Centre experience. Eur J Surg Oncol; 2006 Dec;32(10):1159-64
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  • [Title] Preoperative radiotherapy for soft tissue sarcoma: the Peter MacCallum Cancer Centre experience.
  • AIM: Radiotherapy has been shown to improve local control in combination with limb-sparing or conservative surgery in the management of localised soft tissue sarcoma.
  • METHODS: Consecutive patients with localised extremity or truncal soft tissue sarcoma who presented between January 1996 and December 2000 and treated with preoperative radiotherapy followed by limb-sparing surgery were reviewed.
  • Patients with recurrent disease or metastatic disease at diagnosis and patients below the age of 16years were excluded.
  • CONCLUSION: Preoperative radiotherapy followed by surgery provides effective local control in the management of soft tissue sarcoma.
  • [MeSH-major] Sarcoma / radiotherapy. Sarcoma / surgery. Soft Tissue Neoplasms / radiotherapy. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications. Radiation Injuries. Radiotherapy Dosage. Survival Rate

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  • (PMID = 16765559.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. Manduch M, Oliveira AM, Nascimento AG, Folpe AL: Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature. J Clin Pathol; 2009 Sep;62(9):808-11
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  • 22 morbidly obese adults (mean patient weight 186 kg) presented with unilateral, large soft tissue lesions of longstanding duration.
  • Clinically, most lesions were regarded as representing benign processes, including pedunculated lipoma, lymphocoele or recurrent cellulites, although soft tissue sarcoma was also suspected in two cases.
  • [MeSH-minor] Adult. Aged. Cellulitis / diagnosis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Leg / pathology. Lipoma / diagnosis. Lymphocele / diagnosis. Male. Middle Aged. Obesity, Morbid / complications. Retrospective Studies. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19734477.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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20. Michiels A, Hubens G, Ruppert M, Balliu L, Vaneerdeweg W: Giant liposarcoma of the stomach involving the mediastinum. Acta Chir Belg; 2007 Jul-Aug;107(4):468-71
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  • However 6 months later, the patient died of the recurrent disease.
  • Although liposarcoma is a very common soft tissue sarcoma, it is rarely seen in the stomach.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17966553.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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21. Indelicato DJ, Meadows K, Gibbs CP Jr, Morris CG, Scarborough MT, Zlotecki RA: Effectiveness and morbidity associated with reirradiation in conservative salvage management of recurrent soft-tissue sarcoma. Int J Radiat Oncol Biol Phys; 2009 Jan 1;73(1):267-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness and morbidity associated with reirradiation in conservative salvage management of recurrent soft-tissue sarcoma.
  • PURPOSE: The management of isolated local recurrence of soft-tissue sarcoma is therapeutically complex, and functional conservative management is preferable to radical or amputative salvage surgery.
  • This study reviews the University of Florida experience using conservative resection and reirradiation to manage isolated local recurrences of soft-tissue sarcoma.
  • CONCLUSIONS: Salvage therapy for management of locally recurrent soft-tissue sarcoma is challenging, and the effects of reoperation and reirradiation can be severe.
  • [MeSH-major] Sarcoma / radiotherapy. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Survival. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 18707824.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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22. Bonvalot S, Rimareix F, Causeret S, Le Péchoux C, Boulet B, Terrier P, Le Cesne A, Muret J: Hyperthermic isolated limb perfusion in locally advanced soft tissue sarcoma and progressive desmoid-type fibromatosis with TNF 1 mg and melphalan (T1-M HILP) is safe and efficient. Ann Surg Oncol; 2009 Dec;16(12):3350-7
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  • [Title] Hyperthermic isolated limb perfusion in locally advanced soft tissue sarcoma and progressive desmoid-type fibromatosis with TNF 1 mg and melphalan (T1-M HILP) is safe and efficient.
  • The objective of the present study was to confirm these data on a larger sample size of locally advanced or recurrent extremity soft tissue sarcomas with low-dose TNF-alpha.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Chemotherapy, Cancer, Regional Perfusion. Extremities / pathology. Fibromatosis, Aggressive / therapy. Hyperthermia, Induced. Melphalan / administration & dosage. Sarcoma / therapy. Tumor Necrosis Factor-alpha / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Aged. Drug Therapy, Combination. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Survival Rate. Young Adult

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  • (PMID = 19830495.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Tumor Necrosis Factor-alpha; Q41OR9510P / Melphalan
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23. Maki RG, Kraft AS, Scheu K, Yamada J, Wadler S, Antonescu CR, Wright JJ, Schwartz GK: A multicenter Phase II study of bortezomib in recurrent or metastatic sarcomas. Cancer; 2005 Apr 1;103(7):1431-8
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  • [Title] A multicenter Phase II study of bortezomib in recurrent or metastatic sarcomas.
  • Arm A included patients with osteogenic sarcoma, Ewing sarcoma, and rhabdomyosarcoma.
  • Arm B accrued patients with other types of soft tissue sarcomas.
  • CONCLUSIONS: Bortezomib has minimal activity in soft tissue sarcoma as a single agent.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bone Neoplasms / drug therapy. Boronic Acids / therapeutic use. Proteasome Inhibitors. Pyrazines / therapeutic use. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Bortezomib. Drug Administration Schedule. Fatigue / chemically induced. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / drug therapy. Neoplasm Recurrence, Local / drug therapy. Nervous System Diseases / chemically induced. Treatment Outcome

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 15739208.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CM / N01-CM17105; United States / NCI NIH HHS / CA / P01-CA47179
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Proteasome Inhibitors; 0 / Pyrazines; 69G8BD63PP / Bortezomib
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24. Liebl LS, Elson F, Quaas A, Gawad KA, Izbicki JR: Value of repeat resection for survival in pulmonary metastases from soft tissue sarcoma. Anticancer Res; 2007 Jul-Aug;27(4C):2897-902
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  • [Title] Value of repeat resection for survival in pulmonary metastases from soft tissue sarcoma.
  • BACKGROUND: Pulmonary metastasectomy in soft tissue sarcoma (STS) can lead to long-term survival.
  • The aim of our study was to report on prognostic factors and the value of repeat resection in recurrent disease.
  • CONCLUSION: Patients with repeat resections due to recurrent metastasis show a significantly better prognosis than those with only one resection.
  • Thus, lacking randomised controlled data of the natural course of patients with unresected lung metastases to compare these results, metastasectomy in STS patients is also recommended in recurrent disease.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Sarcoma / secondary. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Humans. Middle Aged. Neoplasm Staging. Reoperation. Survival Rate. Treatment Outcome


25. Hawkins DS, Bradfield S, Whitlock JA, Krailo M, Franklin J, Blaney SM, Adamson PC, Reaman G: Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer; 2006 Nov;47(6):790-4
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  • [Title] Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group study.
  • PURPOSE: The Children's Oncology Group conducted a phase II trial of 21-day continuous infusion topotecan to determine the response rate in pediatric patients with recurrent or refractory malignant solid tumors.
  • PROCEDURE: Patients with Ewing sarcoma family of tumors (ESFT), osteosarcoma (OS), soft tissue sarcomas (STS), medulloblastoma (MB)/primitive neuroectodermal tumor (PNET), astrocytoma, or neuroblastoma (NB) recurrent or refractory to conventional therapy, measurable disease, and adequate organ function were treated with topotecan 0.3 mg/m2/day by continuous intravenous infusion for 21 consecutive days, followed by 7 days without therapy prior to response assessment.
  • CONCLUSION: Intravenous topotecan by 21-day continuous infusion is tolerable in pediatric patients with recurrent or refractory solid tumors.
  • [MeSH-major] Astrocytoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Neuroblastoma / drug therapy. Neuroectodermal Tumors, Primitive / drug therapy. Sarcoma / drug therapy. Topotecan / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Dose-Response Relationship, Drug. Fatigue / chemically induced. Female. Humans. Infusions, Intravenous. Male. Maximum Tolerated Dose. Neutropenia / chemically induced. Recurrence. Survival Rate. Thrombocytopenia / chemically induced. Time Factors. Treatment Outcome


26. Saxena P, Zelei D, Friederich L, Naran A, Newman MA: Recurrent bilateral pneumothoraces associated with metastatic synovial sarcoma. Heart Lung Circ; 2008 Jun;17(3):241-2
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  • [Title] Recurrent bilateral pneumothoraces associated with metastatic synovial sarcoma.
  • [MeSH-major] Hip / pathology. Lung Neoplasms / secondary. Pneumothorax / etiology. Sarcoma, Synovial / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Radiography. Recurrence. Thoracic Surgery, Video-Assisted

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  • (PMID = 18494096.001).
  • [ISSN] 1444-2892
  • [Journal-full-title] Heart, lung & circulation
  • [ISO-abbreviation] Heart Lung Circ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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27. Elco CP, Mariño-Enríquez A, Abraham JA, Dal Cin P, Hornick JL: Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: report of a case providing further evidence for a pathogenetic link. Am J Surg Pathol; 2010 Nov;34(11):1723-7
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  • [Title] Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: report of a case providing further evidence for a pathogenetic link.
  • Myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor are rare, slow-growing soft tissue tumors of the distal extremities with recurrent potential.
  • Here we report a case of a 42-year-old female with a soft tissue tumor of the ankle showing hybrid morphologic features of myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor, a der(10)t(1;10), and abnormalities of chromosome 3.
  • [MeSH-major] Chromosomes, Human. Fibrosarcoma / genetics. Hemosiderosis / genetics. Lipoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Ankle. Biopsy. Chromosome Aberrations. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 10. Chromosomes, Human, Pair 3. Female. Humans. Karyotyping. Magnetic Resonance Imaging. Neoadjuvant Therapy. Orthopedic Procedures. Radiotherapy, Adjuvant. Translocation, Genetic. Treatment Outcome

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  • (PMID = 20871391.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Kawamura-Saito M, Yamazaki Y, Kaneko K, Kawaguchi N, Kanda H, Mukai H, Gotoh T, Motoi T, Fukayama M, Aburatani H, Takizawa T, Nakamura T: Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet; 2006 Jul 1;15(13):2125-37
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  • Ewing's family tumors (EFTs) are highly malignant tumors arising from bone and soft tissues that exhibit EWS-FLI1 or variant EWS-ETS gene fusions in more than 85% of the cases.
  • Here we show that CIC, a human homolog of Drosophila capicua which encodes a high mobility group box transcription factor, is fused to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation t(4;19)(q35;q13).
  • This translocation was seen in two cases of soft tissue sarcoma diagnosed as Ewing-like sarcoma.
  • [MeSH-major] Bone Neoplasms / genetics. Homeodomain Proteins / genetics. Oncogene Proteins, Fusion / metabolism. Repressor Proteins / genetics. Sarcoma, Ewing / genetics. Transcription Factors / genetics
  • [MeSH-minor] Adult. Animals. Base Sequence. Chromosomes, Human, Pair 19 / genetics. Chromosomes, Human, Pair 4 / genetics. DNA-Binding Proteins / genetics. Female. HeLa Cells. Humans. Male. Mice. Middle Aged. Molecular Sequence Data. NIH 3T3 Cells. Promoter Regions, Genetic / genetics. Translocation, Genetic. Tumor Cells, Cultured. Up-Regulation / genetics

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  • (PMID = 16717057.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CIC protein, human; 0 / CIC-DUX4 fusion protein, human; 0 / DNA-Binding Proteins; 0 / DUX4 protein, human; 0 / ETV1 protein, human; 0 / Homeodomain Proteins; 0 / Oncogene Proteins, Fusion; 0 / Repressor Proteins; 0 / Transcription Factors; 0 / transcription factor PEA3
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29. Kuttesch JF Jr, Krailo MD, Madden T, Johansen M, Bleyer A, Children's Oncology Group: Phase II evaluation of intravenous vinorelbine (Navelbine) in recurrent or refractory pediatric malignancies: a Children's Oncology Group study. Pediatr Blood Cancer; 2009 Oct;53(4):590-3
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  • [Title] Phase II evaluation of intravenous vinorelbine (Navelbine) in recurrent or refractory pediatric malignancies: a Children's Oncology Group study.
  • BACKGROUND: A Phase II trial was developed to determine the efficacy and toxicity of intravenous vinorelbine, a semi-synthetic vinca alkaloid, in children, adolescent, and young adults with recurrent or refractory solid malignancies.
  • PROCEDURES: Fifty patients were enrolled among three strata: soft tissue sarcomas [rhabdomyosarcoma (RMS), non-rhabdomyosarcoma, primitive neuroepithelial tumor] (20 patients); brain tumors [astrocytoma (4 patients), medulloblastoma (2 patients), other (16 patients)] (22 patients); neuroblastoma (8 patients).
  • Four responses (one complete, three partial) occurred within the soft tissue sarcoma strata (all with RMS) and two occurred in the brain tumor group (medulloblastoma and astrocytoma).
  • CONCLUSION: Vinorelbine at dose of 30 mg/m(2) can be safely administered to children with recurrent or refractory solid malignancies.
  • The study design identified vinorelbine to be active in the sarcoma category, with a response rate of 36% (4/11) among RMS patients.


30. Grünhagen DJ, Brunstein F, Graveland WJ, van Geel AN, de Wilt JH, Eggermont AM: Isolated limb perfusion with tumor necrosis factor and melphalan prevents amputation in patients with multiple sarcomas in arm or leg. Ann Surg Oncol; 2005 Jun;12(6):473-9
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  • BACKGROUND: Treatment for extremity soft tissue sarcoma (STS) has shifted in recent years from amputation to local wide excision combined with irradiation.
  • From July 1991 to July 2003, out of 217 ILPs, 64 ILPs were performed for either multifocal primary sarcomas or multiple sarcoma recurrences in 53 patients.
  • The time to local recurrence was 29 months and differed significantly between multiple primary and multiple recurrent STS.
  • [MeSH-major] Chemotherapy, Cancer, Regional Perfusion. Limb Salvage. Neoplasms, Second Primary / drug therapy. Sarcoma / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amputation. Arm / pathology. Disease Progression. Female. Humans. Hyperthermia, Induced. Leg / pathology. Male. Middle Aged. Neoplasm Recurrence, Local. Prospective Studies. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 15864484.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Lucas DR, Shukla A, Thomas DG, Patel RM, Kubat AJ, McHugh JB: Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. Am J Surg Pathol; 2010 Jun;34(6):844-51
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  • In 4 tumors the inflammatory myofibroblastic tumor-like areas were diffuse, whereas in 2 they were combined with noninflammatory myofibroblastic tumor-like high-grade sarcoma.
  • All patients developed locally recurrent or metastatic disease.
  • [MeSH-major] Liposarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20431481.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Savar A, Trent J, Al-Zubidi N, Huh W, Anderson P, Shinder R, Esmaeli B: Efficacy of adjuvant and neoadjuvant therapies for adult orbital sarcomas. Ophthal Plast Reconstr Surg; 2010 May-Jun;26(3):185-9
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  • [Title] Efficacy of adjuvant and neoadjuvant therapies for adult orbital sarcomas.
  • PURPOSE: To report a series of adults with orbital soft tissue sarcoma treated with various combinations of chemotherapy, radiation therapy, and surgery and to report on the efficacy of neoadjuvant therapy in these patients.
  • METHODS: The medical records of adults who presented to our institution with orbital soft tissue sarcoma between 2003 and 2008 were reviewed.
  • Nine had primary orbital lesions, 1 had a locally recurrent orbital lesion, 1 had a secondary tumor extending from the paranasal sinuses, and 2 had metastases in the orbit from primary tumors at other sites.
  • Multidisciplinary care with involvement of medical oncologists and radiation oncologists who are familiar with sarcoma chemotherapy and radiation may benefit these patients.
  • [MeSH-major] Chemotherapy, Adjuvant. Neoadjuvant Therapy. Orbital Neoplasms / therapy. Sarcoma / therapy
  • [MeSH-minor] Adult. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Follow-Up Studies. Humans. Male. Middle Aged. Ophthalmologic Surgical Procedures. Radiotherapy. Survival Rate. Treatment Outcome. Visual Acuity / physiology. Young Adult

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  • [CommentIn] Ophthal Plast Reconstr Surg. 2011 Mar-Apr;27(2):142; author reply 142-3 [20966791.001]
  • (PMID = 20489544.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Schuetze SM, Rubin BP, Vernon C, Hawkins DS, Bruckner JD, Conrad EU 3rd, Eary JF: Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy. Cancer; 2005 Jan 15;103(2):339-48
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  • [Title] Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy.
  • BACKGROUND: Patients with high-grade soft tissue sarcomas are at high risk of developing local disease recurrence and metastatic disease.
  • Patients whose tumors had a >/= 40% decline in the SUVmax in response to chemotherapy were at a significantly lower risk of recurrent disease and death after complete resection and adjuvant radiotherapy.
  • CONCLUSIONS: The FDG-PET scan was found to be a useful method with which to predict the outcomes of patients with high-grade extremity soft tissue sarcomas treated with chemotherapy.
  • The FDG-PET scan showed promise as a tool to identify the patients with sarcoma who are most likely to benefit from chemotherapy.
  • [MeSH-major] Fluorodeoxyglucose F18. Positron-Emission Tomography. Sarcoma / drug therapy. Sarcoma / radionuclide imaging. Soft Tissue Neoplasms / drug therapy. Soft Tissue Neoplasms / radionuclide imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Chemotherapy, Adjuvant. Child. Female. Follow-Up Studies. Humans. Lower Extremity. Male. Middle Aged. Multivariate Analysis. Neoadjuvant Therapy. Neoplasm Staging. Orthopedic Procedures / methods. Probability. Prospective Studies. Risk Assessment. Sensitivity and Specificity. Survival Analysis. Treatment Outcome. Upper Extremity

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  • [Copyright] (c) 2004 American Cancer Society.
  • (PMID = 15578712.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA65537; United States / NCI NIH HHS / CA / CA76930; United States / NCI NIH HHS / CA / CA87721
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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34. Daigeler A, Kuhnen C, Hauser J, Goertz O, Tilkorn D, Steinstraesser L, Steinau HU, Lehnhardt M: Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases. World J Surg Oncol; 2008;6:71
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  • [Title] Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases.
  • BACKGROUND: Alveolar sarcoma of the soft parts (ASPS) represents a very rare entity of soft tissue sarcoma with special features such as young peak age incidence and frequent metastasis to the brain.
  • METHODS: From the database of the BG-University Hospital Bergmannsheil, 1597 soft tissue sarcoma (STS) cases were reviewed and 11 consecutive patients with ASPS were isolated.
  • All patients who developed recurrent disease also suffered from distant metastasis, reflecting the aggressive biology of the tumor.
  • In cases with recurrent disease or metastasis, the prognosis is bad and further treatment will be restricted to palliation in most cases.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / therapy
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Extremities. Female. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Survival Analysis. Thoracic Wall. Treatment Outcome


35. Popov P, Barner-Rasmussen I, Tukiainen E: Microvascular flaps and collateral ligament reconstructions for soft tissue sarcomas at the knee joint. Ann Plast Surg; 2010 Jan;64(1):24-7
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  • [Title] Microvascular flaps and collateral ligament reconstructions for soft tissue sarcomas at the knee joint.
  • We report the suitability of free flap reconstruction in defects around the knee joint caused by soft tissue sarcoma (STS) excisions.
  • Of these, 2 patients with solitary soft tissue metastasis were operated, and they are disease free.
  • One patient with medial collateral reconstruction had recurrent patellar displacement and needed further operations; another with lateral collateral ligament and posterior capsular excision, that was not reconstructed, had lateral instability of the knee and needed orthosis.Free flap for STS of the knee is a reliable method.
  • [MeSH-major] Ligaments / surgery. Microsurgery / methods. Reconstructive Surgical Procedures / methods. Sarcoma / surgery. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Knee Joint. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 20023452.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. Abe T, Kamida T, Goda M, Inoue R, Fujiki M, Kobayashi H, Hatano Y, Shibuya H, Fujiwara S, Terashi H, Mori T: Intracranial infiltration by recurrent scalp dermatofibrosarcoma protuberans. J Clin Neurosci; 2009 Oct;16(10):1358-60
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  • [Title] Intracranial infiltration by recurrent scalp dermatofibrosarcoma protuberans.
  • Dermatofibrosarcoma protuberans (DFSP) of the scalp is a rare soft tissue sarcoma.
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Radiosurgery / methods. Young Adult

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  • (PMID = 19560926.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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37. Krempien R, Roeder F, Oertel S, Weitz J, Hensley FW, Timke C, Funk A, Lindel K, Harms W, Buchler MW, Debus J, Treiber M: Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma. Int J Radiat Oncol Biol Phys; 2006 Jul 1;65(3):773-9
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  • [Title] Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma.
  • PURPOSE: This study assesses the long-term outcome of patients with retroperitoneal soft-tissue sarcomas treated by maximal resection in combination with intraoperative electron-beam therapy (IOERT) and postoperative external-beam radiotherapy.
  • METHODS AND MATERIALS: From 1991 to 2004, 67 patients were treated with curative intent for primary (n = 26) or recurrent (n = 41) retroperitoneal soft-tissue sarcoma.
  • [MeSH-major] Neoplasm Recurrence, Local / radiotherapy. Retroperitoneal Neoplasms / radiotherapy. Sarcoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Intraoperative Period. Male. Middle Aged. Radiotherapy Dosage. Retrospective Studies. Statistics, Nonparametric


38. Koppert LB, van Geel AN, Lans TE, van der Pol C, van Coevorden F, Wouters MW: Sternal resection for sarcoma, recurrent breast cancer, and radiation-induced necrosis. Ann Thorac Surg; 2010 Oct;90(4):1102-1108.e2
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  • [Title] Sternal resection for sarcoma, recurrent breast cancer, and radiation-induced necrosis.
  • METHODS: We performed a 25-year retrospective study of 68 patients who underwent a sternectomy for sarcoma, recurrent breast cancer (BC) or radiation-induced necrosis between 1981 and 2006 in two tertiary referral centres (Erasmus Medical Center/Daniel den Hoed Cancer Center and Netherlands Cancer Center/Antoni van Leeuwenhoek Hospital, Netherlands).
  • RESULTS: Sternal resection was performed in 43 sarcoma patients, 17 recurrent BC and 8 patients with radiation-induced necrosis with additional rib resection in the majority of patients and with clavicle resection in 13% of patients.
  • Radical resection was achieved in 80% and 53% of sarcoma and recurrent BC patients, respectively.
  • Five-year overall survival was 64% and 40% in sarcoma and recurrent BC patients, respectively, with 5-year disease-free survivals of 52% and 15%, respectively.
  • CONCLUSIONS: Sarcomas, recurrent BC, and radiation-induced necrosis can be successfully managed by sternal resection and reconstruction with curative intent.
  • Disease-free survival is poor among recurrent BC patients.
  • [MeSH-major] Breast Neoplasms / surgery. Necrosis / surgery. Neoplasm Recurrence, Local / surgery. Radiation Injuries / complications. Sarcoma / surgery. Sternum / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / surgery. Feasibility Studies. Female. Humans. Male. Middle Aged. Retrospective Studies. Soft Tissue Neoplasms / surgery. Survival Analysis. Treatment Outcome. Young Adult


39. Dhillon MS, Mootha AK, Kumar V, Saini R, Bharti S: Low-grade fibromyxoid sarcoma of the talus: a case report. J Foot Ankle Surg; 2010 Jul-Aug;49(4):400.e5-8
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  • [Title] Low-grade fibromyxoid sarcoma of the talus: a case report.
  • Low-grade fibromyxoid sarcoma is a rare tumor, which most commonly arises from the deep soft tissues of the lower extremities in young men.
  • Like many soft tissue tumors, low-grade fibromyxoid sarcoma is also characterized by strong immunoreactivity to the human proto-oncogene BCL-2.
  • In this report, we describe the rare case of a low-grade fibromyxoid sarcoma that appeared to develop as a primary malignancy in the neck of the talus of a young man who presented with recurrent ankle pain after a previous surgery for a cystic lesion at the same site.
  • [MeSH-major] Bone Neoplasms / pathology. Sarcoma / pathology. Talus
  • [MeSH-minor] Adult. Humans. Male

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  • [Copyright] Copyright 2010 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20510633.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Chim H, Tan BK, Tan MH, Tan KC, Song C: Optimizing the use of local muscle flaps for knee megaprosthesis coverage. Ann Plast Surg; 2007 Oct;59(4):398-403
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  • Primary muscle flap cover of megaprostheses following limb salvage surgery for tumors around the knee serves to decrease infection rates, provide additional soft tissue cover over the implant, and act as a bed for split-skin grafting.
  • Between August 1999 and August 2006, 10 patients underwent resection of distal femur (n = 5) or proximal tibia (n = 5) sarcomas, followed by bone reconstruction with a modular megaprosthesis and soft tissue coverage with local pedicled flaps.
  • The average age was 31 years (range, 13 to 47), with pathologic diagnoses inclusive of osteosarcoma (n = 7), chondrosarcoma (n = 2), and recurrent giant cell tumor (n = 1).
  • For proximal tibial tumors, both bellies of the gastrocnemius with hemisoleus for additional soft tissue cover were used.
  • For distal femoral tumors, 1 gastrocnemius belly sutured to the extensor mechanism and gracilis or semimembranosus provided adequate soft tissue cover.
  • [MeSH-major] Bone Neoplasms / surgery. Femoral Neoplasms / surgery. Knee Prosthesis. Sarcoma / surgery
  • [MeSH-minor] Adult. Chondrosarcoma / surgery. Female. Humans. Male. Middle Aged. Osteosarcoma / surgery. Prosthesis Design. Prosthesis Fitting. Surgical Flaps. Tibia


41. Kalra S, Gupta R, Singh S, Gupta K, Kudesia M: Primary cutaneous ewing's sarcoma/primitive neuroectodermal tumor: report of the first case diagnosed on aspiration cytology. Acta Cytol; 2010 Mar-Apr;54(2):193-6
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  • [Title] Primary cutaneous ewing's sarcoma/primitive neuroectodermal tumor: report of the first case diagnosed on aspiration cytology.
  • BACKGROUND: Extraskeletal Ewing's sarcoma (ES) was first recognized as a soft tissue tumor in 1975.
  • Primacy cutaneous occurrence of Ewing's sarcoma/primitive neuroectodermnal tumor (ES/PNET) has been reported in only 31 cases so far.
  • CASE: A young adult presented with a recurrent swelling on the medial aspect of the left leg that had been present for the past 5 years.
  • [MeSH-major] Neuroectodermal Tumors, Primitive / pathology. Sarcoma, Ewing / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Biopsy, Fine-Needle. Cell Adhesion Molecules / metabolism. Humans. Immunohistochemistry. Male. Phosphopyruvate Hydratase / metabolism. S100 Proteins / metabolism. Skin / metabolism. Skin / pathology. Young Adult

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  • (PMID = 20391978.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / S100 Proteins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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42. Jannasch O, Dombrowski F, Lippert H, Meyer F: Rare coincidence of familial adenomatous polyposis and a retroperitoneal fibromyxoid sarcoma: report of a case. Dis Colon Rectum; 2008 Apr;51(4):477-81
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  • [Title] Rare coincidence of familial adenomatous polyposis and a retroperitoneal fibromyxoid sarcoma: report of a case.
  • RESULTS: Histopathologic findings after complete tumor resection showed a low-grade fibromyxoid sarcoma.
  • CT scan and clinical follow-up through 15 months postoperatively revealed no recurrent tumor growth.
  • CONCLUSIONS: To our knowledge, this is the first reported case of familial adenomatous polyposis with metachronous retroperitoneal fibromyxoid sarcoma.
  • In addition to more common semimalignant retroperitoneal desmoid tumors in familial adenomatous polyposis patients, a malignant soft-tissue tumor also has to be considered for differential diagnosis.
  • [MeSH-minor] Adult. Anastomosis, Surgical / methods. Colonic Pouches. Colonoscopy. Diagnosis, Differential. Follow-Up Studies. Humans. Laparotomy. Male. Proctocolectomy, Restorative / methods. Rectum / surgery. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18180996.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Mocellin S, Rossi CR, Brandes A, Nitti D: Adult soft tissue sarcomas: conventional therapies and molecularly targeted approaches. Cancer Treat Rev; 2006 Feb;32(1):9-27
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  • [Title] Adult soft tissue sarcomas: conventional therapies and molecularly targeted approaches.
  • The therapeutic approach to soft tissue sarcomas (STS) has evolved over the past two decades based on the results from randomized controlled trials, which are guiding physicians in the treatment decision-making process.
  • Despite significant improvements in the control of local disease, a significant number of patients ultimately die of recurrent/metastatic disease following radical surgery due to a lack of effective adjuvant treatments.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Sarcoma / metabolism. Sarcoma / therapy
  • [MeSH-minor] Adult. Aged. Angiogenesis Inhibitors / therapeutic use. Cancer Vaccines / therapeutic use. Chemotherapy, Adjuvant. Enzyme Inhibitors / therapeutic use. Genetic Therapy. Growth Substances / metabolism. Humans. Matrix Metalloproteinase Inhibitors. Middle Aged. Radiotherapy, Adjuvant. Randomized Controlled Trials as Topic

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  • (PMID = 16338075.001).
  • [ISSN] 0305-7372
  • [Journal-full-title] Cancer treatment reviews
  • [ISO-abbreviation] Cancer Treat. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Cancer Vaccines; 0 / Enzyme Inhibitors; 0 / Growth Substances; 0 / Matrix Metalloproteinase Inhibitors
  • [Number-of-references] 234
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44. Postovsky S, Barzilai M, Meller I, Kollander Y, Futerman B, Ben Arush MW: Does regular follow-up influence the survival of patients with sarcoma after recurrence? The Miri Shitrit pediatric oncology department experience. J Pediatr Hematol Oncol; 2008 Mar;30(3):189-95
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  • [Title] Does regular follow-up influence the survival of patients with sarcoma after recurrence? The Miri Shitrit pediatric oncology department experience.
  • This study was undertaken to evaluate whether regular follow-up improves overall survival of children with recurrent sarcomas.
  • The medical charts of 107 children diagnosed with soft tissue and bone sarcomas were reviewed, of whom 29 relapsed.
  • (3) other diagnostic and treatment approaches are needed to improve the survival of children with recurrent sarcomas.
  • [MeSH-major] Bone Neoplasms / mortality. Neoplasm Recurrence, Local / mortality. Oncology Service, Hospital / statistics & numerical data. Outcome Assessment (Health Care) / statistics & numerical data. Sarcoma / mortality. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Bone Marrow Examination. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Israel. Magnetic Resonance Imaging. Male. Positron-Emission Tomography. Predictive Value of Tests. Prognosis. Recurrence. Retrospective Studies. Survival Analysis. Survival Rate. Time. Tomography, X-Ray Computed

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  • (PMID = 18376279.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Absalon MJ, McCarville MB, Liu T, Santana VM, Daw NC, Navid F: Pulmonary nodules discovered during the initial evaluation of pediatric patients with bone and soft-tissue sarcoma. Pediatr Blood Cancer; 2008 Jun;50(6):1147-53
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  • [Title] Pulmonary nodules discovered during the initial evaluation of pediatric patients with bone and soft-tissue sarcoma.
  • BACKGROUND: Recent technical advances in CT imaging and data processing have improved the ability to detect small pulmonary nodules in children with bone and soft-tissue sarcoma undergoing radiologic imaging of the chest.
  • PROCEDURE: We retrospectively studied medical records and CT chest scans at initial diagnosis of 210 children and young adults presenting to a single pediatric tertiary care hospital specialized in oncology for evaluation of bone or soft-tissue sarcoma.
  • Having more than three nodules and a bilateral distribution were associated with histology-proven metastasis (P = 0.002 and P = 0.011, respectively) and an increased frequency of recurrent or progressive metastatic disease in the lung (P < 0.001 and P = 0.023, respectively).
  • CONCLUSIONS: Pulmonary nodules were commonly detected during the initial evaluation of pediatric cases of sarcoma.
  • [MeSH-major] Bone Neoplasms / pathology. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Radiography, Thoracic. Sarcoma / pathology. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Male. Solitary Pulmonary Nodule / radiography


46. Akan M, Eker Uluçay G, Kargi B, Yildirim S, Aköz T: Combined reconstruction of complex defects of the chest wall. Scand J Plast Reconstr Surg Hand Surg; 2006;40(2):93-100
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  • Three had had recurrent breast carcinoma, seven relapse after excision of a sarcoma, two had had lesions of the chest wall after irradiation, and one had a sternal fistula.
  • Local skin, musculocutaneous and free latissimus dorsi and anterolateral thigh flaps were done to cover soft tissue.
  • The use of Marlex mesh-methylmethacrylate sandwich prostheses for the stabilisation of the skeleton and local musculocutaneous flaps for covering soft tissues after resection of three or more ribs is effective.

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  • (PMID = 16537256.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Polypropylenes; 196OC77688 / Methylmethacrylate
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47. Bölke E, Ruf L, Budach W, Reinecke P, Röhrborn A, Pape H, Schwarz A, Schmitt G, Aul C: Tandem high-dose chemotherapy supported by autologous peripheral blood stem-cell transplantation and radiotherapy for recurrent malignant fibrous histiocytoma. Wien Klin Wochenschr; 2005 Dec;117(23-24):833-6
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  • [Title] Tandem high-dose chemotherapy supported by autologous peripheral blood stem-cell transplantation and radiotherapy for recurrent malignant fibrous histiocytoma.
  • Malignant fibrous histiocytoma (MFH) is a soft-tissue sarcoma created from fibroblast cells and characterized by a high rate of metastasis or recurrence with poor prognosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Hematopoietic Stem Cell Transplantation. Histiocytoma, Malignant Fibrous / therapy. Radiotherapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Thoracic Surgery. Transplantation, Autologous. Treatment Outcome


48. Schramm N, Schlemmer M, Rist C, Issels R, Reiser MF, Berger F: [Combined functional and morphological imaging of sarcomas: significance for diagnostics and therapy monitoring]. Radiologe; 2010 Apr;50(4):339-48
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  • (18)F-fluorodeoxyglucose positron-emission tomography (FDG-PET) and especially hybrid FDG-PET/CT is becoming more and more accepted for the clinical management of adult and pediatric patients with sarcomas.
  • For patients with primary bone and soft tissue sarcomas FDG-PET/CT is utilized for diagnosis, staging and restaging, metabolic tumor grading, guidance of biopsies, detection of tumor recurrence and therapy monitoring.
  • Contrast-enhanced MRI remains a key tool in the diagnosis of recurrent disease, especially in tumors which are not hypermetabolic.
  • More research is necessary to prospectively compare dynamic contrast-enhanced MRI and FDG-PET/CT for evaluation of local and recurrent diseases.
  • [MeSH-major] Fluorodeoxyglucose F18. Magnetic Resonance Imaging / trends. Positron-Emission Tomography / trends. Sarcoma / diagnosis. Sarcoma / therapy. Subtraction Technique / trends. Tomography, X-Ray Computed / trends
  • [MeSH-minor] Adult. Germany. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Neoplasm Staging. Prognosis. Radiopharmaceuticals. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 20221579.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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49. Tanaka H, Sasayama T, Nishihara M, Arai A, Kawamura A, Kanomata N, Itoh T, Kohmura E: Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report. Neurol Med Chir (Tokyo); 2010;50(8):689-93
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  • [Title] Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report.
  • A 33-year-old woman presented with rare brain metastases from undifferentiated high-grade sarcoma manifesting as headache and vomiting.
  • Magnetic resonance (MR) imaging demonstrated multiple tumors in the brain, subcutaneous soft tissue, and mediastinum.
  • The histological diagnosis was undifferentiated high-grade sarcoma.
  • Promoter hypermethylation in the O(6)-methylguanine-deoxyribonucleic acid methyltransferase (MGMT) genes was detected and MGMT protein expression was negative in the recurrent tumor, so temozolomide (TMZ) salvage chemotherapy was given, and follow-up MR imaging showed tumor reduction.
  • This case suggests that TMZ may be effective for brain metastasis of undifferentiated sarcoma without MGMT protein expression.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Brain Neoplasms / therapy. Dacarbazine / analogs & derivatives. Neoplasm Recurrence, Local / therapy. Sarcoma / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. DNA Modification Methylases / genetics. DNA Modification Methylases / metabolism. DNA Repair Enzymes / genetics. DNA Repair Enzymes / metabolism. Female. Gene Silencing. Humans. Salvage Therapy. Soft Tissue Neoplasms / enzymology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / therapy. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism

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  • (PMID = 20805657.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Tumor Suppressor Proteins; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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50. Petera J, Soumarová R, Růzicková J, Neumanová R, Dusek L, Sirák I, Macingová Z, Paluska P, Kasaová L, Hodek M, Vosmik M: Perioperative hyperfractionated high-dose rate brachytherapy for the treatment of soft tissue sarcomas: multicentric experience. Ann Surg Oncol; 2010 Jan;17(1):206-10
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  • [Title] Perioperative hyperfractionated high-dose rate brachytherapy for the treatment of soft tissue sarcomas: multicentric experience.
  • BACKGROUND: Low-dose rate brachytherapy is a well-established adjuvant treatment for soft tissue sarcomas (STS).
  • METHODS: Forty-five patients with primary (17 cases) or recurrent (28 cases) STS were treated with resection and HDR BT between 1998 and 2007.
  • [MeSH-major] Brachytherapy. Neoplasm Recurrence, Local / radiotherapy. Sarcoma / radiotherapy
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Perioperative Care. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 19711130.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Santaella Y, Borrego I, López J, Ortiz MJ, Vázquez R: [18-FDG-PET in a case of recurrent malignant schwannoma]. Rev Esp Med Nucl; 2005 Mar-Apr;24(2):127-30
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  • [Title] [18-FDG-PET in a case of recurrent malignant schwannoma].
  • The peripheral nerve sarcoma, also called malignant schwannoma, is originally a soft tissue sarcoma.
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 15745683.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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52. Eyesan SU, Obalum DC, Onovo DO, Ketiku KK, Abdulkareem FB: Clinico-pathologic patterns of extremity liposarcoma. Niger Postgrad Med J; 2010 Mar;17(1):27-9
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  • RESULTS: Liposarcoma accounted for 6 [27.3%] of 22 cases of soft tissue sarcomas seen within the study period.
  • Survival and recurrent rates could not be determined as all patients were lost to follow-up soon after surgery.
  • CONCLUSION: Liposarcoma is the commonest extremity soft tissue sarcoma seen in our centre, the myxoid type being the commonest histologic subtype.
  • [MeSH-major] Liposarcoma / pathology. Liposarcoma / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Extremities. Follow-Up Studies. Hospitals, Special. Humans. Male. Middle Aged. Neoplasm Staging. Nigeria. Orthopedics. Prospective Studies. Radiotherapy, Adjuvant. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 20348979.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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53. van Akkooi AC, Verhoef C, van Geel AN, Kliffen M, Eggermont AM, de Wilt JH: Sentinel node biopsy for clear cell sarcoma. Eur J Surg Oncol; 2006 Nov;32(9):996-9
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  • [Title] Sentinel node biopsy for clear cell sarcoma.
  • Clear cell sarcoma (CCS), also known as clear cell sarcoma of tendons and aponeuroses or malignant melanoma of soft tissue, is a rare malignant tumor and is histogenitically related to melanoma.
  • Only the patients with tumor positive SNs developed recurrent disease during an average follow-up of 33 months.
  • None of the negative SN patients developed recurrent disease and all were alive after an average follow-up of 39 months.
  • SN status seems to predict additional nodal involvement and recurrent disease as well as survival.
  • [MeSH-major] Lymphatic Metastasis / radionuclide imaging. Sarcoma, Clear Cell / pathology. Sentinel Lymph Node Biopsy. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Lymph Node Excision. Male. Middle Aged. Radiopharmaceuticals. Technetium Tc 99m Aggregated Albumin. Treatment Outcome

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  • (PMID = 16672185.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Technetium Tc 99m Aggregated Albumin; 0 / technetium Tc 99m nanocolloid
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54. Bestic JM, Peterson JJ, Bancroft LW: Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions [corrected]. Radiographics; 2009 Sep-Oct;29(5):1487-500
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  • Ewing sarcoma family tumors account for approximately 3% of all pediatric cancers, making them the second most common bone malignancies in children and adolescents.
  • Advances in the treatment of localized disease have dramatically prolonged the survival of patients in whom Ewing sarcoma is diagnosed, but the prognosis for patients with metastatic or recurrent disease remains poor.
  • Radiologic evaluation of Ewing sarcoma can help (a) detect and accurately assess the extent of disease prior to treatment, (b) determine whether metastatic or recurrent disease is present, and (c) monitor therapy response.
  • Standard imaging evaluation of bone and soft-tissue sarcomas typically consists of conventional radiography, magnetic resonance (MR) imaging, computed tomography (CT), and bone scintigraphy.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / therapy. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods. Sarcoma, Ewing / radionuclide imaging. Sarcoma, Ewing / therapy
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Neoplasm Staging. Prognosis. Radiopharmaceuticals. Treatment Outcome. Young Adult

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  • [Copyright] (c) RSNA, 2009.
  • [CommentIn] Radiographics. 2009 Sep-Oct;29(5):1500-1; discussion 1501 [19764110.001]
  • [ErratumIn] Radiographics. 2010 Jan-Feb;30(1):301
  • (PMID = 19755607.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 21
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55. Rossi CR, Mocellin S, Pilati P, Foletto M, Campana L, Quintieri L, De Salvo GL, Lise M: Hyperthermic isolated perfusion with low-dose tumor necrosis factor alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcomas. Ann Surg Oncol; 2005 May;12(5):398-405
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  • [Title] Hyperthermic isolated perfusion with low-dose tumor necrosis factor alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcomas.
  • BACKGROUND: Tumor necrosis factor (TNF)-alpha-based hyperthermic isolated limb perfusion (HILP) is one of the most active available approaches for locally advanced soft tissue sarcomas (STS) of the limbs.
  • METHODS: HILP with low-dose TNF-alpha (1 mg) and DXR (8.5 mg/L of limb volume) was given to 21 patients with limb-threatening STS: 14 had primary and 7 had recurrent STS, most of which were high grade (grade 1, n = 3; grade 2, n = 6; grade 3, n = 12).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Chemotherapy, Cancer, Regional Perfusion. Doxorubicin / administration & dosage. Hyperthermia, Induced. Sarcoma / drug therapy. Tumor Necrosis Factor-alpha / administration & dosage
  • [MeSH-minor] Adult. Aged. Female. Humans. Male

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  • (PMID = 15915374.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; 80168379AG / Doxorubicin
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56. Thway K, Fisher C, Debiec-Rychter M, Calonje E: Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum Pathol; 2009 Nov;40(11):1586-90
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  • [Title] Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma.
  • Low-grade fibromyxoid sarcoma is a soft tissue sarcoma with recurrent and low metastatic potential, which has characteristic FUS-CREB3L2 or FUS-CREB3L1 fusions.
  • Low-grade fibromyxoid sarcoma and perineurioma can appear morphologically similar, particularly in small biopsy specimens, and distinction between the 2 entities is important for appropriate treatment.
  • Low-grade fibromyxoid sarcoma is negative for most immunohistochemical markers, whereas perineuriomas stain variably for epithelial membrane antigen, CD34 and claudin-1, a tight-junction associated protein.
  • We studied 15 cases of genetically proven low-grade fibromyxoid sarcoma that at least focally resembled perineurioma, with antibodies to claudin-1 and epithelial membrane antigen.
  • This has implications toward the accurate diagnosis of both tumors, and, as positivity for claudin-1 in low-grade fibromyxoid sarcoma is not previously documented, suggests that there might be underdiagnosis of low-grade fibromyxoid sarcoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Fibrosarcoma / pathology. Membrane Proteins / biosynthesis. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Claudin-1. Diagnosis, Differential. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Mucin-1 / biosynthesis. Young Adult

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  • (PMID = 19540561.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Membrane Proteins; 0 / Mucin-1
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57. Germain MA, Bonvalot S, Rimareix F, Missana CM: [Locally advanced soft-tissue sarcomas. An innovating triad to avoid amputation: isolated limb perfusion, TNFalpha, and free microsurgical flap]. Bull Acad Natl Med; 2010 Jan;194(1):51-65; discussion 65-7
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  • [Title] [Locally advanced soft-tissue sarcomas. An innovating triad to avoid amputation: isolated limb perfusion, TNFalpha, and free microsurgical flap].
  • We retrospectively studied the benefits of isolated limb perfusion combined with TNFalpha administration and free flap reconstruction in locally advanced soft-tissue sarcomas of the limbs.
  • Between 2000 and 2008, we treated 37 patients (22 women and 15 men) with locally advanced soft tissue sarcomas.
  • They were multifocal in 8 cases and recurrent in 15 cases.
  • Sarcoma excision was combined with a complementary procedure in 10 patients (vascular graft or nerve anastomosis).
  • Three major improvements were made in recent years, namely isolated limb perfusion, TNFalpha administration, and free flap reconstruction two months after resection of residual sarcoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Cancer, Regional Perfusion. Extremities / surgery. Sarcoma / drug therapy. Sarcoma / surgery. Soft Tissue Neoplasms / drug therapy. Soft Tissue Neoplasms / surgery. Tumor Necrosis Factor-alpha / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lung Neoplasms / mortality. Lung Neoplasms / secondary. Male. Middle Aged. Muscle, Skeletal / transplantation. Neoadjuvant Therapy. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / surgery. Neoplasms, Radiation-Induced / drug therapy. Neoplasms, Radiation-Induced / surgery. Neoplasms, Second Primary / drug therapy. Neoplasms, Second Primary / surgery. Radiotherapy, Adjuvant. Reconstructive Surgical Procedures. Reoperation. Retrospective Studies. Skin Transplantation. Surgical Flaps. Treatment Outcome. Young Adult

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  • (PMID = 20669559.001).
  • [ISSN] 0001-4079
  • [Journal-full-title] Bulletin de l'Académie nationale de médecine
  • [ISO-abbreviation] Bull. Acad. Natl. Med.
  • [Language] fre
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha
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58. Eilber FC, Brennan MF, Riedel E, Alektiar KM, Antonescu CR, Singer S: Prognostic factors for survival in patients with locally recurrent extremity soft tissue sarcomas. Ann Surg Oncol; 2005 Mar;12(3):228-36
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  • [Title] Prognostic factors for survival in patients with locally recurrent extremity soft tissue sarcomas.
  • BACKGROUND: Factors prognostic for survival in patients with locally recurrent extremity soft tissue sarcomas (STS) are poorly defined, thus making it difficult to identify high-risk patients who may benefit from adjuvant therapy.
  • CONCLUSIONS: Histological grade, local recurrence size, and local recurrence-free interval are independently predictive of survival in patients with locally recurrent extremity STS.
  • [MeSH-major] Extremities. Neoplasm Recurrence, Local. Sarcoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Lower Extremity / pathology. Lower Extremity / surgery. Male. Middle Aged. Prognosis. Risk Factors. Upper Extremity / pathology. Upper Extremity / surgery

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  • (PMID = 15827815.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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59. Llácer C, Delannes M, Minsat M, Stoeckle E, Votron L, Martel P, Bonnevialle P, Nguyen Bui B, Chevreau C, Kantor G, Daly-Schveitzer N, Thomas L: Low-dose intraoperative brachytherapy in soft tissue sarcomas involving neurovascular structure. Radiother Oncol; 2006 Jan;78(1):10-6
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  • [Title] Low-dose intraoperative brachytherapy in soft tissue sarcomas involving neurovascular structure.
  • BACKGROUND AND PURPOSE: To evaluate intraoperative brachytherapy in the management of soft tissue sarcomas involving neurovascular structures, its impact on local control and complications.
  • Brachytherapy was part of the initial treatment (79 cases) or performed in recurrent disease (19 cases).
  • CONCLUSIONS: Intraoperative brachytherapy is efficient with excellent local control rates in soft tissue sarcomas presenting with neurovascular involvement and offers an acceptable conservative option.
  • [MeSH-major] Brachytherapy. Sarcoma / radiotherapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Intraoperative Period. Iridium Radioisotopes / therapeutic use. Male. Middle Aged. Survival Analysis

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  • (PMID = 16376446.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Iridium Radioisotopes
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60. Goel V, Goel A, Gupta N, Bhamre S: Flap reconstruction and interstitial brachytherapy in nonextremity soft tissue sarcoma. J Cancer Res Ther; 2007 Apr-Jun;3(2):105-7
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  • [Title] Flap reconstruction and interstitial brachytherapy in nonextremity soft tissue sarcoma.
  • Radiotherapy is an integral component of management of high-grade soft tissue sarcomas.
  • We preset our initial experience with interstitial brachytherapy in two patients of recurrent high-grade non-extremity sarcomas treated with surgical excision and soft tissue reconstruction of surgical defect.
  • [MeSH-major] Brachytherapy. Sarcoma / therapy. Scapula. Surgical Flaps
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17998734.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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61. Rehders A, Peiper M, Stoecklein NH, Alexander A, Boelke E, Knoefel WT, Rogiers X: Hepatic metastasectomy for soft-tissue sarcomas: is it justified? World J Surg; 2009 Jan;33(1):111-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic metastasectomy for soft-tissue sarcomas: is it justified?
  • BACKGROUND: Except for patients with gastrointestinal stromal tumors (GIST), systemic chemotherapy in patients with liver metastasis of soft-tissue sarcoma (STS) is not effective.
  • Repeated resection for recurrent tumor was performed in eight patients, which yielded a median survival of 76 months.
  • [MeSH-major] Liver Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Sarcoma / surgery. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Kaplan-Meier Estimate. Longitudinal Studies. Male. Middle Aged. Neoplasm Staging. Reoperation. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 18949511.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Lehnert T, Cardona S, Hinz U, Willeke F, Mechtersheimer G, Treiber M, Herfarth C, Buechler MW, Schwarzbach MH: Primary and locally recurrent retroperitoneal soft-tissue sarcoma: local control and survival. Eur J Surg Oncol; 2009 Sep;35(9):986-93
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  • [Title] Primary and locally recurrent retroperitoneal soft-tissue sarcoma: local control and survival.
  • AIM: To evaluate local control for long-term prognosis in retroperitoneal soft-tissue sarcoma (primary tumors (PT) and local recurrence (LR)).
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Retroperitoneal Neoplasms / surgery. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Proportional Hazards Models. Survival Analysis. Treatment Outcome

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  • (PMID = 19138832.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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63. Gronchi A, Casali PG, Mariani L, Miceli R, Fiore M, Lo Vullo S, Bertulli R, Collini P, Lozza L, Olmi P, Rosai J: Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution. J Clin Oncol; 2005 Jan 1;23(1):96-104
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  • [Title] Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution.
  • PURPOSE: To explore the prognostic effect of microscopic marginal status after surgery for extremity soft tissue sarcomas.
  • Six hundred forty-two were first seen with a primary tumor, and 269, with a locally recurrent tumor.
  • This would seem to justify a policy of surgical adequacy in adult soft tissue sarcomas, though clinical decision making in borderline presentations for conservative surgery might be reasonably flexible and shared with the patient.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Arm. Female. Follow-Up Studies. Humans. Leg. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 15625364.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Leibl S, Moinfar F: Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation. Am J Surg Pathol; 2006 Apr;30(4):450-6
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  • [Title] Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation.
  • We present an extensive immunohistochemical analysis of 7 mammary sarcomas that did not fit into any specific soft tissue sarcoma category.
  • Other myoepithelial markers and steroid receptors were absent, except androgen receptors, which were expressed in one sarcoma.
  • The distinction of specific, histogenetically defined sarcoma entities (such as leiomyosarcoma, angiosarcoma, liposarcoma) from NOS-type sarcoma with CD10 expression is usually clear-cut because the former exhibit a characteristic histomorphology and immunoprofile.
  • Phyllodes tumors with stromal overgrowth or recurrent phyllodes tumors lacking epithelial structures as well as periductal stromal sarcomas can be ruled out by their frequent expression of CD34 and negativity for myoepithelial markers.
  • The immunophenotype of NOS-type sarcomas with CD10 expression suggests that these neoplasms represent a mammary sarcoma variant with myoepithelial features.
  • [MeSH-major] Breast Neoplasms / pathology. Myoepithelioma / pathology. Neprilysin / metabolism. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinosarcoma / diagnosis. Cell Transformation, Neoplastic. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged


65. Yang P, Yang LH, Gu LJ, Wang JY: [Feasibility of thoracoscopic pulmonary metastasectomy]. Ai Zheng; 2005 Oct;24(10):1249-51
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  • Postoperative locoregional relapse occurred in 5 patients, in which 4 patients had multiple metastases, the rest 1 patient with soft tissue sarcoma underwent a second thoracoscopic resection of recurrent pulmonary lesion.
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / pathology. Colorectal Neoplasms / pathology. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies. Survival Rate

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  • (PMID = 16219142.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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66. Serizawa I, Kagei K, Kamada T, Imai R, Sugahara S, Okada T, Tsuji H, Ito H, Tsujii H: Carbon ion radiotherapy for unresectable retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys; 2009 Nov 15;75(4):1105-10
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  • PURPOSE: To evaluate the applicability of carbon ion radiotherapy (CIRT) for unresectable retroperitoneal sarcomas with regard to normal tissue morbidity and local tumor control.
  • METHODS AND MATERIALS: From May 1997 to February 2006, 24 patients (17 male and 7 female) with unresectable retroperitoneal sarcoma received CIRT.
  • Of the patients, 16 had primary disease and 8 recurrent disease.
  • [MeSH-major] Carbon Radioisotopes / therapeutic use. Neoplasm Recurrence, Local / radiotherapy. Retroperitoneal Neoplasms / radiotherapy. Sarcoma / radiotherapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Carbon. Female. Follow-Up Studies. Humans. Magnetic Resonance Spectroscopy. Male. Middle Aged. Radiodermatitis / pathology. Radiotherapy Dosage. Relative Biological Effectiveness. Survival Rate. Tomography, X-Ray Computed. Tumor Burden. Young Adult

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  • (PMID = 19467578.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Radioisotopes; 7440-44-0 / Carbon
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67. Gupta AA, Pappo AS: New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children. Future Oncol; 2006 Oct;2(5):675-85
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  • [Title] New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children.
  • Children with relapsed, recurrent or metastatic sarcomas represent a therapeutic challenge for the pediatric oncologist.
  • For example, drug development in rhabdomyosarcoma has relied upon the preclinical xenograft model, whereas therapies for pediatric nonrhabdomyosarcomatous soft tissue sarcomas have mostly been derived from adult trials.
  • [MeSH-major] Camptothecin / analogs & derivatives. Drug Design. Sarcoma / drug therapy. Sarcoma / secondary. Topotecan / therapeutic use

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  • (PMID = 17026459.001).
  • [ISSN] 1479-6694
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Topoisomerase I Inhibitors; 7673326042 / irinotecan; 7M7YKX2N15 / Topotecan; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 82
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68. Wang WL, Mayordomo E, Zhang W, Hernandez VS, Tuvin D, Garcia L, Lev DC, Lazar AJ, López-Terrada D: Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts). Mod Pathol; 2009 Sep;22(9):1201-9
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  • [Title] Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts).
  • Unlike melanoma, clear cell sarcoma harbors either a t(12;22)(q13;q12) recurrent translocation, resulting in an EWSR1/ATF1 chimeric gene, or less commonly a t(2;22)(q34;q12) translocation fusing EWSR1 and CREB1.
  • Fluorescence in situ hybridization (FISH) analysis using the LSI EWSR1 break-apart probe and a reverse transcription polymerase chain reaction (RT-PCR) assay optimized for formalin-fixed paraffin-embedded tissue to detect all four reported EWSR1/ATF1 clear cell sarcoma chimeric types and the EWSR1/CREB1 variant was performed.
  • Consequently, both techniques are equally effective in assessing for an EWSR1 rearrangement and are useful ancillary diagnostic tests for clear cell sarcoma.
  • In addition, EWSR1-CREB1 was identified in a clear cell sarcoma of soft tissue providing further evidence that this chimeric variant is not exclusive to gastrointestinal clear cell sarcomas and should be included in RT-PCR assays of soft tissue clear cell sarcomas.
  • [MeSH-major] CREB-Binding Protein / genetics. Calmodulin-Binding Proteins / genetics. Oncogene Proteins, Fusion / genetics. RNA-Binding Proteins / genetics. Sarcoma, Clear Cell / genetics. Soft Tissue Neoplasms / genetics. Transcription Factors / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction. Young Adult

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  • (PMID = 19561568.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CREBBP protein, human; 0 / Calmodulin-Binding Proteins; 0 / EWS-ATF1 fusion protein, human; 0 / EWSR1 protein, human; 0 / EWSR1-CREB1 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Proteins; 0 / Transcription Factors; EC 2.3.1.48 / CREB-Binding Protein
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69. Lasithiotakis K, Economou G, Gogas H, Ioannou C, Perisynakis K, Filis D, Kastana O, Bafaloukos D, Decatris M, Catodritis N, Frangia K, Papadakis G, Magarakis M, Tsoutsos D, Chrysos E, Chalkiadakis G, Zoras O: Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: feasibility and reproducibility in a multi-institutional Hellenic collaborative study. Oncol Rep; 2010 Apr;23(4):1077-83
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  • [Title] Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: feasibility and reproducibility in a multi-institutional Hellenic collaborative study.
  • Herein, we present the experience of the Hellenic collaborating centers with TM-HILP for inoperable in-transit melanoma and soft tissue sarcoma (STS) of the extremities to examine safety and feasibility of collaborating as a multi-institutional group for future research studies.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Chemotherapy, Cancer, Regional Perfusion / methods. Hyperthermia, Induced / methods. Melanoma / drug therapy. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Greece. Humans. Leg. Male. Melphalan / administration & dosage. Melphalan / adverse effects. Middle Aged. Reproducibility of Results. Retrospective Studies. Tumor Necrosis Factor-alpha / administration & dosage. Tumor Necrosis Factor-alpha / adverse effects

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  • (PMID = 20204294.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; Q41OR9510P / Melphalan
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70. Chiappa A, Zbar AP, Bertani E, Biffi R, Luca F, Crotti C, Testori A, Lazzaro G, De Pas T, Pace U, Andreoni B: Primary and recurrent retroperitoneal soft tissue sarcoma: prognostic factors affecting survival. J Surg Oncol; 2006 May 1;93(6):456-63
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  • [Title] Primary and recurrent retroperitoneal soft tissue sarcoma: prognostic factors affecting survival.
  • BACKGROUND AND OBJECTIVES: To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS).
  • RESULTS: Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration.
  • CONCLUSIONS: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival.
  • [MeSH-major] Neoplasm Recurrence, Local / mortality. Retroperitoneal Neoplasms / mortality. Retroperitoneal Neoplasms / surgery. Sarcoma / mortality. Sarcoma / surgery
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Prognosis. Survival Analysis. Survivors

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16615149.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. Waters B, Panicek DM, Lefkowitz RA, Antonescu CR, Healey JH, Athanasian EA, Brennan MF: Low-grade myxofibrosarcoma: CT and MRI patterns in recurrent disease. AJR Am J Roentgenol; 2007 Feb;188(2):W193-8
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  • [Title] Low-grade myxofibrosarcoma: CT and MRI patterns in recurrent disease.
  • This study was undertaken to determine and show patterns of recurrent low-grade myxofibrosarcoma at CT and MRI.
  • CONCLUSION: Unlike in most other histologic types of low-grade soft-tissue sarcoma, recurrent low-grade myxofibrosarcoma often is infiltrative; shows a tapering, tail-like margin and superficial spreading configuration; and metastasizes to various distant sites, including lungs, pleura, bone, adrenal gland, soft tissue, and mesentery.
  • Knowledge of these unusual characteristics is important in assessing the presence and extent of recurrent low-grade myxofibrosarcoma before surgical reexcision.
  • [MeSH-major] Fibrosarcoma / diagnosis. Magnetic Resonance Imaging / methods. Neoplasm Recurrence, Local / diagnosis. Soft Tissue Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Image Enhancement / methods. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17242227.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Fréneaux P: [Soft tissue non lymphoid malignant round cell tumors in childhood and adolescence: morphological, immunophenotypic, and molecular features of diagnosis]. Ann Pathol; 2006 Apr;26(2):97-109
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  • [Title] [Soft tissue non lymphoid malignant round cell tumors in childhood and adolescence: morphological, immunophenotypic, and molecular features of diagnosis].
  • Soft tissue non lymphoid malignant round cell tumors observed in children and adolescents are rare and are very different from adult tumors.
  • They are often undifferentiated and distinctive key morphologic features are often lacking, but, on the other hand, specific recurrent genetic alterations, mostly translocations, are distinctive.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Chromosome Mapping. Diagnosis, Differential. Humans. Immunophenotyping. Lung Neoplasms / pathology. Neuroblastoma / pathology. Neuroectodermal Tumors, Primitive / pathology. Paraganglioma / pathology. Rhabdoid Tumor / pathology. Rhabdomyosarcoma / pathology. Sarcoma, Ewing / pathology

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  • (PMID = 16791121.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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73. van Ginkel RJ, Thijssens KM, Pras E, van der Graaf WT, Suurmeijer AJ, Hoekstra HJ: Isolated limb perfusion with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma: three time periods at risk for amputation. Ann Surg Oncol; 2007 Apr;14(4):1499-506
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  • [Title] Isolated limb perfusion with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma: three time periods at risk for amputation.
  • BACKGROUND: The aim of this study was to investigate the long-term limb salvage rate and overall survival after isolated limb perfusion (ILP) with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma (STS).
  • The first was within a year after perfusion, mainly as a result of massive necrosis of the tumor and overlying skin, resulting in soft tissue deficit or recurrent disease (n = 17).
  • [MeSH-major] Amputation. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Cancer, Regional Perfusion. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melphalan / administration & dosage. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Risk Factors. Survival Rate. Tumor Necrosis Factor-alpha / administration & dosage

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  • (PMID = 17253101.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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  • [Other-IDs] NLM/ PMC1914273
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74. Abbott DE, Halverson AL, Wayne JD, Kim JY, Talamonti MS, Dumanian GA: The oblique rectus abdominal myocutaneous flap for complex pelvic wound reconstruction. Dis Colon Rectum; 2008 Aug;51(8):1237-41
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  • Compared to other flaps, the oblique rectus abdominal myocutaneous flap provides increased soft tissue to fill pelvic dead space, with the further advantage of intact skin to close perineal defects.
  • Indications for flap reconstruction included abdominal perineal resection for anal/rectal cancer, pelvic sarcoma/sacral resection/exenteration, small bowel/colonic fistula resection, and total proctocolectomy with vaginal reconstruction.
  • A single recurrent fistula required operative resection three months postoperatively.
  • This technique provides ample tissue for large pelvic wounds, including skin for perineal defects.
  • Comparing our results to existing literature, the oblique rectus abdominal myocutaneous flap displays a favorable morbidity profile, providing a safe means of delivering well-vascularized tissue to the pelvic cavity and perineal floor.
  • [MeSH-minor] Adult. Aged. Female. Humans. Intestinal Fistula / surgery. Male. Middle Aged. Pelvic Exenteration. Perineum / surgery. Postoperative Complications / surgery. Retrospective Studies. Treatment Outcome. Vagina / surgery

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  • (PMID = 18481146.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Park JO, Qin LX, Prete FP, Antonescu C, Brennan MF, Singer S: Predicting outcome by growth rate of locally recurrent retroperitoneal liposarcoma: the one centimeter per month rule. Ann Surg; 2009 Dec;250(6):977-82
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  • [Title] Predicting outcome by growth rate of locally recurrent retroperitoneal liposarcoma: the one centimeter per month rule.
  • OBJECTIVE: To identify the prognostic variables that predict disease-specific survival and second local recurrence-free survival in patients with recurrent retroperitoneal liposarcoma so as to guide clinical management.
  • METHODS: From a prospective sarcoma database we selected 105 patients who had at least one local recurrence following complete resection of a primary retroperitoneal liposarcoma between July 1982 and December 2005.
  • CONCLUSIONS: Local recurrence growth rate is strongly associated with disease-specific survival and local control for patients with completely resected locally recurrent retroperitoneal liposarcoma.

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  • (PMID = 19953716.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA047179-17; United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS344379; NLM/ PMC3248745
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76. Okamoto Y, Minami M, Ueda T, Inadome Y, Tatsumura M, Sakane M: Extraskeletal mesenchymal chondrosarcoma of the cervical meninx. Radiat Med; 2007 Aug 01;25(7):355-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case of recurrent mesenchymal chondrosarcoma in the cervical paravertebral region that was diagnosed preoperatively by imaging studies.
  • However, it appeared as a soft tissue sarcoma of lower intensity than common cartilaginous tumors on T2-weighted magnetic resonance imaging (MRI).
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 17705006.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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77. Lahat G, Dhuka AR, Lahat S, Smith KD, Pollock RE, Hunt KK, Ravi V, Lazar AJ, Lev D: Outcome of locally recurrent and metastatic angiosarcoma. Ann Surg Oncol; 2009 Sep;16(9):2502-9
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  • [Title] Outcome of locally recurrent and metastatic angiosarcoma.
  • BACKGROUND: Angiosarcoma (AS) is a rare soft tissue sarcoma with an enhanced propensity for local and systemic failure.
  • The outcome of locally recurrent and metastatic AS treated at a single institution was evaluated.
  • RESULTS: Forty-four patients were treated for locally recurrent AS; the majority (59%) were <or=5 cm; the most common sites were skin (48%) and breast (32%).
  • Multivariable analysis identified size >5 cm as the only independent adverse prognosticator of recurrent AS-specific survival [hazard ratio (HR): 3.26, P = 0.04].
  • CONCLUSION: Locally recurrent AS is often treatable; complete resection can potentially prolong survival.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19551444.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Mertens F, Fletcher CD, Antonescu CR, Coindre JM, Colecchia M, Domanski HA, Downs-Kelly E, Fisher C, Goldblum JR, Guillou L, Reid R, Rosai J, Sciot R, Mandahl N, Panagopoulos I: Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. Lab Invest; 2005 Mar;85(3):408-15
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  • [Title] Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene.
  • Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that is often mistaken for either more benign or more malignant tumor types.
  • Cytogenetic analyses have identified a recurrent balanced translocation t(7;16) (q32-34;p11), later shown by molecular genetic approaches to result in a FUS/CREB3L2 fusion gene.
  • For this purpose, a series of potential LGFMS were obtained from nine different soft-tissue tumor centres and subjected to molecular analysis as well as careful histopathologic review.
  • [MeSH-major] Biomarkers, Tumor / genetics. Chromosomes, Human, Pair 16 / genetics. Chromosomes, Human, Pair 7 / genetics. Fibrosarcoma / genetics. Nerve Tissue Proteins / genetics. RNA-Binding Protein FUS / genetics. Soft Tissue Neoplasms / genetics. Transcription Factors / genetics. Translocation, Genetic
  • [MeSH-minor] Adolescent. Adult. Aged. Amino Acid Sequence. Base Sequence. Child. Cyclic AMP Response Element-Binding Protein. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Molecular Sequence Data. Recombinant Fusion Proteins / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15640831.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CREB3L1 protein, human; 0 / Cyclic AMP Response Element-Binding Protein; 0 / Nerve Tissue Proteins; 0 / RNA-Binding Protein FUS; 0 / Recombinant Fusion Proteins; 0 / Transcription Factors
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79. Mondaini N, Palli D, Saieva C, Nesi G, Franchi A, Ponchietti R, Tripodi S, Miracco C, Meliani E, Carini M, Livi L, Zanna I, Trovarelli S, Marino V, Vignolini G, Pomara G, Orlando V, Giubilei G, Selli C, Rizzo M: Clinical characteristics and overall survival in genitourinary sarcomas treated with curative intent: a multicenter study. Eur Urol; 2005 Apr;47(4):468-73
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  • OBJECTIVES: Adult soft tissue sarcomas in general, and those arising from the urological organs in particular, are a group of rare tumours with a generally poor prognosis, only a few studies are available.
  • METHODS: Pre-treatment and follow-up data were obtained from 22 adult patients, all residing in Tuscany, treated consecutively between 1984 and 2002 for primary or locally recurrent genito-urinary sarcomas in 8 urology departments in the area.
  • All cases were classified according to the French Federation of Cancer Center System Grading Scheme for Adult Sarcomas (FFCC) and Broders System.
  • CONCLUSIONS: In our representative series, 3 tumor parameters (site, size and grade) appeared to represent the most important prognostic factors in adult genitourinary sarcomas.
  • [MeSH-major] Sarcoma / mortality. Urogenital Neoplasms / mortality
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Survival Rate

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  • (PMID = 15774243.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Netherlands
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80. Balke M, Campanacci L, Gebert C, Picci P, Gibbons M, Taylor R, Hogendoorn P, Kroep J, Wass J, Athanasou N: Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone. BMC Cancer; 2010;10:462
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  • [Title] Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone.
  • METHOD: In this study, we have examined clinical and radiological outcomes of treatment with aminobisphosphonates on 25 cases of aggressive primary, recurrent and metastatic GCTB derived from four European centres.
  • Most inoperable sacral/pelvic tumours did not increase in size and no further recurrence was seen in GCTBs that had repeatedly recurred in bone and soft tissues.
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Resorption. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Osteoclasts / drug effects. Osteoclasts / pathology. Treatment Outcome. Tumor Cells, Cultured. Young Adult

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  • (PMID = 20799989.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Diphosphonates; 0 / Imidazoles; 6XC1PAD3KF / zoledronic acid
  • [Other-IDs] NLM/ PMC2940802
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81. Mierzwa ML, McCluskey CM, Barrett WL, Lowy A, Sussman J, Sorger J: Interstitial brachytherapy for soft tissue sarcoma: A single institution experience. Brachytherapy; 2007 Oct-Dec;6(4):298-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interstitial brachytherapy for soft tissue sarcoma: A single institution experience.
  • PURPOSE: Soft tissue sarcomas (STSs) are an uncommon, histologically diverse group of malignancies, which are primarily treated with surgery.
  • METHODS AND MATERIALS: Forty-three patients were treated from 1997 to 2005 with adjuvant BTX for primary or recurrent STS.
  • Thirty-four patients were treated for primary and nine for recurrent disease in locations including upper and lower extremity, pelvis, superficial trunk, and retroperitoneum.
  • No patient with low-grade sarcoma developed distant metastasis.
  • [MeSH-major] Brachytherapy / methods. Sarcoma / radiotherapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17959424.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Chen F, Fujinaga T, Sato K, Sonobe M, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H: Significance of tumor recurrence before pulmonary metastasis in pulmonary metastasectomy for soft tissue sarcoma. Eur J Surg Oncol; 2009 Jun;35(6):660-5
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  • [Title] Significance of tumor recurrence before pulmonary metastasis in pulmonary metastasectomy for soft tissue sarcoma.
  • BACKGROUND: Resection for pulmonary metastasis from soft tissue sarcomas is an accepted method for treatment, but it is still debatable which patients will benefit from surgical intervention.
  • METHODS: Between 1990 and 2007, 23 patients with pulmonary metastases from soft tissue sarcomas underwent complete pulmonary resection.
  • In addition, repeat metastasectomy for recurrent pulmonary metastasis also provided a favorable overall survival (P=0.041).
  • CONCLUSIONS: Our data suggested that patients most likely to benefit from pulmonary metastasectomy for soft tissue sarcoma have no tumor recurrence before pulmonary metastasis.
  • Furthermore, patients with repeat metastasectomy for recurrent pulmonary metastasis also presented a significantly longer survival.
  • [MeSH-major] Lung Neoplasms / surgery. Neoplasm Recurrence, Local / mortality. Pneumonectomy / mortality. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Survival Analysis. Young Adult

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  • (PMID = 18774675.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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83. Erzen D, Novak J, Spiler M, Sencar M: Aggressive surgical treatment of retroperitoneal sarcoma: long-term experience of a single institution. Surg Technol Int; 2007;16:97-106
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  • [Title] Aggressive surgical treatment of retroperitoneal sarcoma: long-term experience of a single institution.
  • Surgery is the main modality in the therapy of retroperitoneal soft-tissue sarcomas (RSTS).
  • A retrospective study was undertaken to evaluate the results of aggressive surgical treatment in a series of patients of primary and recurrent retroperitoneal sarcomas.
  • The five- and ten-year survival rates of patients with localized sarcoma were 52% and 38%, respectively.
  • When only R0 resection was considered, referral status (primary, residual, recurrent RSTS) influenced survival (p = 0.004).
  • Unless no other treatment modalities are available, aggressive surgery for recurrent sarcoma is recommended.
  • [MeSH-major] Postoperative Complications / surgery. Retroperitoneal Neoplasms / mortality. Retroperitoneal Neoplasms / surgery. Sarcoma / mortality. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Longitudinal Studies. Male. Middle Aged. Risk Assessment / methods. Risk Factors. Slovenia / epidemiology. Young Adult

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  • (PMID = 17429776.001).
  • [ISSN] 1090-3941
  • [Journal-full-title] Surgical technology international
  • [ISO-abbreviation] Surg Technol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Rehders A, Hosch SB, Scheunemann P, Stoecklein NH, Knoefel WT, Peiper M: Benefit of surgical treatment of lung metastasis in soft tissue sarcoma. Arch Surg; 2007 Jan;142(1):70-5; discission 76
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  • [Title] Benefit of surgical treatment of lung metastasis in soft tissue sarcoma.
  • HYPOTHESIS: Patients with pulmonary metastatic soft tissue sarcoma benefit from resection, with long-term cure possible.
  • PATIENTS: Between January 1, 1991, and December 31, 2002, 61 patients (33 men and 28 women; median age at initial diagnosis, 42 years [age range, 18-74 years]) were surgically treated for pulmonary metastases of soft tissue sarcoma at University Hospital, Hamburg-Eppendorf, Germany.
  • CONCLUSIONS: Patients with lung metastasis from soft tissue sarcomas benefit from surgical excision.
  • Long-term survival is possible even when recurrent pulmonary disease is resected.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Sarcoma / secondary
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Histiocytoma / secondary. Histiocytoma / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Proportional Hazards Models. Sternum / surgery. Survival Analysis. Thoracotomy


85. Leow AM, Halim AS, Wan Z: Reconstructive treatment following resection of high-grade soft-tissue sarcomas of the lower limb. J Orthop Surg (Hong Kong); 2005 Apr;13(1):58-63
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  • [Title] Reconstructive treatment following resection of high-grade soft-tissue sarcomas of the lower limb.
  • PURPOSE: To review the role of free tissue transfer in reconstructive surgery following resection of high-grade soft-tissue sarcomas of the lower limb.
  • METHODS: Medical records of all consecutive patients with high-grade soft-tissue sarcomas of the lower limbs between August 1997 and September 2003 were reviewed.
  • RESULTS: Of 8 patients (6 women and 2 men) aged between 19 and 65 years, 4 had malignant fibrous histiocytoma, one had malignant peripheral nerve sheath tumour, one had synovial sarcoma, one had recurrent liposarcoma, and one had epitheloid sarcoma.
  • The soft-tissue defects following tumour extirpation ranged from 153 cm(2) to 896 cm(2).
  • CONCLUSION: Tissue transfer allows early adjuvant therapy facilitating the multimodal approach for the high-grade soft-tissue sarcomas of the lower extremity.
  • [MeSH-major] Lower Extremity. Reconstructive Surgical Procedures / methods. Sarcoma / surgery. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Female. Humans. Limb Salvage. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 15872402.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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86. Dziewirski W, Rutkowski P, Nowecki ZI, Sałamacha M, Morysiński T, Kulik A, Kawczyńska M, Kasprowicz A, Lyczek J, Ruka W: Surgery combined with intraoperative brachytherapy in the treatment of retroperitoneal sarcomas. Ann Surg Oncol; 2006 Feb;13(2):245-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The purpose of this study was to analyze the results of treatment of retroperitoneal soft tissue sarcomas (RSTS) by surgery combined with intraoperative brachytherapy (IOBRT).
  • METHODS: Seventy adult patients with RSTS were considered for combined treatment (surgery plus IOBRT) between June 1998 and February 2004.
  • There were 64 (91%) recurrent tumors, and 93% of tumors exceeded 5 cm.
  • [MeSH-major] Brachytherapy. Neoplasm Recurrence, Local / radiotherapy. Retroperitoneal Neoplasms / radiotherapy. Sarcoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Humans. Intraoperative Care. Male. Middle Aged. Poland / epidemiology. Prognosis. Radiotherapy Dosage. Survival Rate

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  • (PMID = 16411144.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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87. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • Sclerosing epithelioid fibrosarcoma (SEF) has distinctive morphology and occurs mainly in deep soft tissue of adult extremities.
  • Inclusion required OMFR location, an abundantly sclerotic sarcoma with epithelioid features, and lack of other phenotype by immunohistochemistry.
  • Tumor location included the infra-temporal fossa, buccal mucosa (recurrence extending into bone), anterior mandible (intraosseous primary, focally extending into soft tissue), and left parotid and submandibular gland (with metaplastic bone) regions.
  • One case had no recurrent/residual disease at 3 months.
  • OMFRSEF occur in adults in various locations, but with a common propensity to involve bone; there is recurrent potential and morbidity with higher grade lesions.
  • [MeSH-major] Facial Bones / pathology. Fibrosarcoma / pathology. Maxilla / pathology. Mouth Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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88. Lans TE, Grünhagen DJ, de Wilt JH, van Geel AN, Eggermont AM: Isolated limb perfusions with tumor necrosis factor and melphalan for locally recurrent soft tissue sarcoma in previously irradiated limbs. Ann Surg Oncol; 2005 May;12(5):406-11
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  • [Title] Isolated limb perfusions with tumor necrosis factor and melphalan for locally recurrent soft tissue sarcoma in previously irradiated limbs.
  • BACKGROUND: Recurrent extremity soft tissue sarcoma (STS) in a previously operated and irradiated area can usually be managed only by amputation.
  • Out of 342 TNF-based ILPs between 1991 and 2003, 30 ILPs were performed in 26 patients with recurrent STS in the irradiated field after prior surgery and radiotherapy.
  • CONCLUSIONS: TNF-based ILP can avoid amputations in most patients with recurrent extremity STS in a prior operated and irradiated field.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Chemotherapy, Cancer, Regional Perfusion. Limb Salvage / methods. Melphalan / administration & dosage. Neoplasm Recurrence, Local / drug therapy. Sarcoma / drug therapy. Tumor Necrosis Factor-alpha / administration & dosage
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Arm. Combined Modality Therapy. Female. Humans. Leg. Male. Middle Aged

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  • (PMID = 15915375.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Tumor Necrosis Factor-alpha; Q41OR9510P / Melphalan
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89. Baratti D, Pennacchioli E, Casali PG, Bertulli R, Lozza L, Olmi P, Collini P, Radaelli S, Fiore M, Gronchi A: Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol; 2007 Dec;14(12):3542-51
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  • [Title] Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution.
  • BACKGROUND: Epithelioid sarcoma (ES) is a rare subtype of soft-tissue sarcoma of unknown histogenesis.
  • Thirty-six patients presented with a primary and 18 with a recurrent tumor.
  • Thirty patients relapsed; in detail, local and distant failure occurred in 14 (25.9%) and 24 (44.4%) patients, respectively.
  • [MeSH-major] Epithelioid Cells / pathology. Sarcoma / mortality. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17909905.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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90. Mitsuhashi A, Nagai Y, Suzuka K, Yamazawa K, Nojima T, Nikaido T, Ishikura H, Matsui H, Shozu M: Primary synovial sarcoma in fallopian tube: case report and literature review. Int J Gynecol Pathol; 2007 Jan;26(1):34-7
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  • [Title] Primary synovial sarcoma in fallopian tube: case report and literature review.
  • Synovial sarcoma, a malignant mesenchymal neoplasm, occurs mostly near the joints of the extremities and occasionally outside the joint such as lung.
  • We report a case of soft tissue sarcoma arising in the fallopian tube origin that showed characteristic pathological appearance of biphasic synovial sarcoma.
  • Molecular analysis detected a fusion gene transcript of synovial sarcoma translocation (SYT) gene from chromosome 18 and synovial sarcoma X chromosome breakpoint 1 (SSX1) gene, which is believed to pathognomonic for synovial sarcoma of joint origin.
  • Recurrent abdominal tumor, observed at 12 month after the initial surgery and following chemotherapy using doxorubicin, cisplatin and ifosfamide, partially responded to chemotherapy using paclitaxel and carboplatin and, then, optimal surgery was performed.
  • This is the first report of a synovial sarcoma arising in the fallopian tube.
  • [MeSH-major] Fallopian Tube Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Base Sequence. Female. Humans. Oncogene Proteins, Fusion / genetics

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  • (PMID = 17197895.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
  • [Number-of-references] 12
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91. Navid F, Willert JR, McCarville MB, Furman W, Watkins A, Roberts W, Daw NC: Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer; 2008 Jul 15;113(2):419-25
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  • [Title] Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma.
  • METHODS: A retrospective case review of 22 patients with recurrent or refractory bone or soft-tissue sarcomas who received gemcitabine (at a dose of 675 mg/m(2) intravenously on Days 1 and 8) and docetaxel (at a dose of 75-100 mg/m(2) intravenously on Day 8) was undertaken.
  • Seventeen patients had osteosarcoma, 2 patients had Ewing sarcoma family of tumors (ESFT), 1 patient had a malignant fibrous histiocytoma (MFH), 1 patient had a chondrosarcoma, and 1 patient had an undifferentiated sarcoma.
  • CONCLUSIONS: In the current study, gemcitabine in combination with docetaxel was found to be well tolerated and demonstrated antitumor activity in children and adolescents with recurrent or refractory osteosarcoma and MFH.
  • [MeSH-minor] Adolescent. Adult. Child. Dose-Response Relationship, Drug. Female. Humans. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18484657.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA21765; United States / NCI NIH HHS / CA / CA23099
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids; 0W860991D6 / Deoxycytidine; 15H5577CQD / docetaxel; B76N6SBZ8R / gemcitabine
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92. Hanna SA, David LA, Gikas PD, Tindall AJ, Cannon SR, Briggs TW: Very late local recurrence of Ewing's sarcoma--can you ever say 'cured'? A report of two cases and literature review. Ann R Coll Surg Engl; 2008 Oct;90(7):W12-5
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  • [Title] Very late local recurrence of Ewing's sarcoma--can you ever say 'cured'? A report of two cases and literature review.
  • We report two rare cases of very late local recurrence of Ewing's sarcoma, occurring 16 years and 19 years after treatment of the primary tumour.
  • The two patients were eventually referred back to our institution after the diagnosis of recurrent Ewing's sarcoma was established.
  • [MeSH-major] Bone Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Sarcoma, Ewing / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 18831863.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC2728314
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93. Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M: Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol; 2009 May;33(5):705-19
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  • Cases harboring a sarcomatoid carcinoma featured a malignant epithelial component composed of varying combinations of BCAC-HG, BCAC-LG, IAC-NOS, or squamous cell carcinoma, whereas the sarcomatoid component appeared as either a pleomorphic or spindle-cell sarcoma.
  • V654E), whereas a living descendant of another deceased patient demonstrated a recurrent nonsense germline mutation in exon 20 (c. 2806C>T, p. R936X).
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Australia. Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Cell Differentiation. Chromosomes, Human, Pair 16. Europe. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged. Mutation. Neoplasm Invasiveness. South Africa. Syndrome. Treatment Outcome. Tumor Suppressor Proteins / genetics


94. Ballo MT, Zagars GK, Pollock RE, Benjamin RS, Feig BW, Cormier JN, Hunt KK, Patel SR, Trent JC, Beddar S, Pisters PW: Retroperitoneal soft tissue sarcoma: an analysis of radiation and surgical treatment. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):158-63
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  • [Title] Retroperitoneal soft tissue sarcoma: an analysis of radiation and surgical treatment.
  • PURPOSE: To evaluate the clinical outcomes of patients with localized retroperitoneal soft tissue sarcoma (STS) treated with complete surgical resection and radiation.
  • Multivariate analysis also indicated an inferior 5-year LC rate for patients presenting with recurrent disease, positive or uncertain resection margins, and age greater than 65 years.
  • [MeSH-major] Retroperitoneal Neoplasms / radiotherapy. Retroperitoneal Neoplasms / surgery. Sarcoma / radiotherapy. Sarcoma / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local. Radiotherapy Dosage. Retrospective Studies

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  • (PMID = 17084545.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 06294
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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95. Evans SM, Fraker D, Hahn SM, Gleason K, Jenkins WT, Jenkins K, Hwang WT, Zhang P, Mick R, Koch CJ: EF5 binding and clinical outcome in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys; 2006 Mar 1;64(3):922-7
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  • [Title] EF5 binding and clinical outcome in human soft tissue sarcomas.
  • PURPOSE: To study the 2-nitroimidazole agent EF5 as a surrogate for measuring hypoxia in a series of patients with soft tissue sarcomas, and to determine whether hypoxia measured with this technique was associated with patient outcome.
  • METHODS AND MATERIALS: Patients with soft tissue sarcomas of the head and neck, extremity, trunk, or retroperitoneum for whom surgical excision was the initial treatment of choice, were given 21 mg/kg EF5 24-48 hours before surgery.
  • RESULTS: Two patients with recurrent and 14 patients with de novo sarcomas were studied.
  • [MeSH-major] Cell Hypoxia / physiology. Etanidazole / analogs & derivatives. Hydrocarbons, Fluorinated / metabolism. Indicators and Reagents / metabolism. Neoplasm Recurrence, Local / metabolism. Sarcoma / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Survival Analysis. Treatment Outcome

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  • (PMID = 16458778.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00040; United States / NCI NIH HHS / CA / R01 CA 75285
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; 0 / Hydrocarbons, Fluorinated; 0 / Indicators and Reagents; 30DKA3Q1HL / Etanidazole
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96. Tran PT, Hara W, Su Z, Lin HJ, Bendapudi PK, Norton J, Teng N, King CR, Kapp DS: Intraoperative radiation therapy for locally advanced and recurrent soft-tissue sarcomas in adults. Int J Radiat Oncol Biol Phys; 2008 Nov 15;72(4):1146-53
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  • [Title] Intraoperative radiation therapy for locally advanced and recurrent soft-tissue sarcomas in adults.
  • PURPOSE: To analyze the outcomes of and identify prognostic factors for patients treated with surgery and intraoperative radiotherapy (IORT) for locally advanced and recurrent soft-tissue sarcoma in adults from a single institution.
  • Seventy percent of patients had recurrent disease failing prior surgery (70%) and/or radiation (32%).
  • [MeSH-major] Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Sarcoma / radiotherapy. Sarcoma / surgery. Soft Tissue Neoplasms / radiotherapy. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. California / epidemiology. Humans. Incidence. Intraoperative Care / methods. Male. Middle Aged. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Survival Rate

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  • (PMID = 18394818.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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97. Noel KE, Mardirossian G, Schneider L: Primary intraosseous Kaposi's sarcoma presenting as an asymptomatic periapical radiolucency: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):e65-70
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  • [Title] Primary intraosseous Kaposi's sarcoma presenting as an asymptomatic periapical radiolucency: a case report.
  • Kaposi's sarcoma (KS) is a common mucocutaneous manifestation of acquired immunodeficiency syndrome (AIDS).
  • Excision of the lesion revealed a fleshy, pink-red soft tissue mass with a uniform consistency.
  • One year after surgical procedure, the surgical defect showed radiographic evidence of repair and there was no sign of recurrent tumor.
  • [MeSH-major] HIV Infections / complications. Mandibular Neoplasms / complications. Sarcoma, Kaposi / complications
  • [MeSH-minor] Adult. Fatal Outcome. Herpesvirus 8, Human / isolation & purification. Humans. Immunoenzyme Techniques. Male

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  • (PMID = 17317238.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Cranshaw IM, Gikas PD, Fisher C, Thway K, Thomas JM, Hayes AJ: Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol; 2009 Sep;35(9):994-8
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  • Locoregional recurrent disease was more common in those with malignant histopathological findings compared to those with benign histopathology (6/18 vs 0/15 p 0.021).
  • Those tumours with atypical or malignant features on histological examination have poor prognosis and should be managed and followed up in the same manner as other high-grade soft tissue tumours.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. London. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19345055.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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99. Idbaih A, Coindre JM, Derré J, Mariani O, Terrier P, Ranchère D, Mairal A, Aurias A: Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. Lab Invest; 2005 Feb;85(2):176-81
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  • Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma.
  • Losses found in the chromosomal arms 1q, 2q, 3p, 4q, 10q, 11q and 13q were also recurrent.
  • Moreover, pLPS-mMFH represented, according to the clustering software results, an entity clearly distinguished from other soft tissue sarcomas, LMS in particular, with which they share common genetic aberrations.
  • The characterization of common gene alterations in both tumor groups would suggest a closer relationship between these two types of soft tissue sarcomas.
  • [MeSH-major] Chromosome Deletion. Chromosomes, Human. Histiocytoma, Benign Fibrous / genetics. Liposarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosome Mapping. Female. Humans. In Situ Hybridization. Karyotyping. Male. Middle Aged


100. Bilici A, Ustaalioglu BB, Seker M, Kayahan S: Case report: soft tissue metastasis from immature teratoma of the testis: second case report and review of the literature. Clin Orthop Relat Res; 2010 Sep;468(9):2541-4
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  • [Title] Case report: soft tissue metastasis from immature teratoma of the testis: second case report and review of the literature.
  • Spread to soft tissue, however, is rare with only four cases with seminoma reported.
  • However, one case with metastasis of testicular immature teratoma to soft tissue was documented previously.
  • CASE DESCRIPTION: We report the case of a 38-year-old man with recurrent immature teratoma of the testis who presented with a painless soft tissue mass in the left thigh previously treated with standard chemotherapy.
  • After removal of the soft tissue mass, his serum alpha-fetoprotein level had returned to the normal range.
  • LITERATURE REVIEW: To our knowledge, this is the second case of immature teratoma of the testis metastasized to soft tissue.
  • PURPOSES AND CLINICAL RELEVANCE: We suggest that for a man with testicular cancer who has a soft tissue mass, metastasis of soft tissue from testicular cancer and other solid malignancies should be considered in the differential diagnosis of a soft tissue mass together with primary soft tissue sarcoma.
  • [MeSH-major] Soft Tissue Neoplasms / secondary. Teratoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Brain Neoplasms / therapy. Chorionic Gonadotropin, beta Subunit, Human / blood. Cranial Irradiation. Humans. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Magnetic Resonance Imaging. Male. Orchiectomy. Thigh. Treatment Outcome. alpha-Fetoproteins / metabolism

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  • (PMID = 19937408.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
  • [Number-of-references] 17
  • [Other-IDs] NLM/ PMC2919860
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