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1. Koppert LB, van Geel AN, Lans TE, van der Pol C, van Coevorden F, Wouters MW: Sternal resection for sarcoma, recurrent breast cancer, and radiation-induced necrosis. Ann Thorac Surg; 2010 Oct;90(4):1102-1108.e2
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  • [Title] Sternal resection for sarcoma, recurrent breast cancer, and radiation-induced necrosis.
  • METHODS: We performed a 25-year retrospective study of 68 patients who underwent a sternectomy for sarcoma, recurrent breast cancer (BC) or radiation-induced necrosis between 1981 and 2006 in two tertiary referral centres (Erasmus Medical Center/Daniel den Hoed Cancer Center and Netherlands Cancer Center/Antoni van Leeuwenhoek Hospital, Netherlands).
  • RESULTS: Sternal resection was performed in 43 sarcoma patients, 17 recurrent BC and 8 patients with radiation-induced necrosis with additional rib resection in the majority of patients and with clavicle resection in 13% of patients.
  • Radical resection was achieved in 80% and 53% of sarcoma and recurrent BC patients, respectively.
  • Five-year overall survival was 64% and 40% in sarcoma and recurrent BC patients, respectively, with 5-year disease-free survivals of 52% and 15%, respectively.
  • [MeSH-major] Breast Neoplasms / surgery. Necrosis / surgery. Neoplasm Recurrence, Local / surgery. Radiation Injuries / complications. Sarcoma / surgery. Sternum / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bone Neoplasms / surgery. Feasibility Studies. Female. Humans. Male. Middle Aged. Retrospective Studies. Soft Tissue Neoplasms / surgery. Survival Analysis. Treatment Outcome. Young Adult


2. Hanna SA, Whittingham-Jones P, Sewell MD, Pollock RC, Skinner JA, Saifuddin A, Flanagan A, Cannon SR, Briggs TW: Outcome of intralesional curettage for low-grade chondrosarcoma of long bones. Eur J Surg Oncol; 2009 Dec;35(12):1343-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual. Retrospective Studies

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  • (PMID = 19570648.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Penel N, Watelle F, Vanhuyse M, Adenis A: [Treatment of adult patients with metastatic sarcoma: current shift in concepts]. Bull Cancer; 2010 Jun;97(6):687-91
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  • [Title] [Treatment of adult patients with metastatic sarcoma: current shift in concepts].
  • We describe herein the current concepts tested in clinical trials dedicated to patients with metastatic soft tissue sarcomas: identify predictive factors under anthracyclin-based regimens, identify patients beneficing from polychemotherapy, benefit of maintenance treatment, use of non-progression rate rather than response rate for selecting new drugs, histology-tailored or biological target-tailored second-line treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Doxorubicin / administration & dosage. Humans. Sirolimus / administration & dosage. Sirolimus / analogs & derivatives

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  • (PMID = 20462829.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 48Z35KB15K / ridaforolimus; 80168379AG / Doxorubicin; W36ZG6FT64 / Sirolimus
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4. Lachenmayer A, Yang Q, Eisenberger CF, Boelke E, Poremba C, Heinecke A, Ohmann C, Knoefel WT, Peiper M: Superficial soft tissue sarcomas of the extremities and trunk. World J Surg; 2009 Aug;33(8):1641-9
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  • [Title] Superficial soft tissue sarcomas of the extremities and trunk.
  • BACKGROUND: Superficial soft tissue sarcomas (sSTS) are an important and frequent subtype of soft tissue sarcoma (STS).
  • [MeSH-major] Extremities / pathology. Sarcoma / surgery. Thoracic Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Prognosis. Proportional Hazards Models. Risk Factors. Survival Rate

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  • (PMID = 19430830.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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5. Landa J, Schwartz LH: Contemporary imaging in sarcoma. Oncologist; 2009 Oct;14(10):1021-38
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  • [Title] Contemporary imaging in sarcoma.
  • It is imperative to obtain appropriate imaging of these tumors in order to adequately assess, characterize, and stage bone and soft tissue sarcomas.
  • [MeSH-major] Bone Neoplasms / diagnosis. Fluorodeoxyglucose F18. Positron-Emission Tomography. Radiopharmaceuticals. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Metastasis / diagnosis. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19789392.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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6. Dziewirski W, Rutkowski P, Nowecki ZI, Sałamacha M, Morysiński T, Kulik A, Kawczyńska M, Kasprowicz A, Lyczek J, Ruka W: Surgery combined with intraoperative brachytherapy in the treatment of retroperitoneal sarcomas. Ann Surg Oncol; 2006 Feb;13(2):245-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The purpose of this study was to analyze the results of treatment of retroperitoneal soft tissue sarcomas (RSTS) by surgery combined with intraoperative brachytherapy (IOBRT).
  • METHODS: Seventy adult patients with RSTS were considered for combined treatment (surgery plus IOBRT) between June 1998 and February 2004.
  • [MeSH-major] Brachytherapy. Neoplasm Recurrence, Local / radiotherapy. Retroperitoneal Neoplasms / radiotherapy. Sarcoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Humans. Intraoperative Care. Male. Middle Aged. Poland / epidemiology. Prognosis. Radiotherapy Dosage. Survival Rate

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  • (PMID = 16411144.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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7. Bui MM, Bagui TK, Boulware DC, Letson DG, Nasir A, Kaiser HE, Pledger WJ, Coppola D: Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. In Vivo; 2007 Sep-Oct;21(5):729-37
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  • [Title] Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms.
  • Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas.
  • MATERIALS AND METHODS: Twenty-nine human bone and soft tissue sarcomas were evaluated.
  • Tissue sections from each case were subjected to immunostaining for cyclin D1, cyclin D3 and Ki-67 using the avidin-biotin complex method.
  • Cyclin D3, however, was expressed in all of the sarcoma types including 2 out of 5 liposarcomas and 1 out of 4 osteosarcomas.
  • The normal soft tissue adjacent to the tumors when present (10 cases) was negative for cyclin D1 and D3, and expressed Ki-67 in 5% of the cell nuclei.
  • The expression of cyclin D3 was also noted in human sarcoma cell lines (SKLMS, MG63, SaOS-2 and HT1080) by Western blot.
  • CONCLUSION: The higher expression of cyclin D1 and D3 and of Ki-67 in bone and soft tissue sarcomas, as compared to leiomyomas and peritumoral normal soft tissue, suggests that high cyclin expression may contribute to deregulation of the cell cycle in bone and soft tissue tumors.
  • [MeSH-major] Bone Neoplasms / metabolism. Cell Cycle Proteins / metabolism. Cyclin D1 / metabolism. Cyclins / metabolism. Gene Expression Regulation, Neoplastic. Ki-67 Antigen / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line, Tumor. Cyclin D3. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18019405.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CCND3 protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin D3; 0 / Cyclins; 0 / Ki-67 Antigen; 136601-57-5 / Cyclin D1
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8. Alkuwari E, Gravel DH: A 30-year-old man with a soft tissue mass on the right elbow. Inflammatory myxohyaline tumor of the distal extremities with prominent eosinophilic infiltrate. Arch Pathol Lab Med; 2006 Mar;130(3):e35-6
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  • [Title] A 30-year-old man with a soft tissue mass on the right elbow. Inflammatory myxohyaline tumor of the distal extremities with prominent eosinophilic infiltrate.
  • [MeSH-major] Eosinophils / pathology. Fibrosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Elbow / pathology. Extremities / pathology. Hodgkin Disease / diagnosis. Humans. Inflammation / diagnosis. Male. Sarcoma / diagnosis. Vimentin / analysis

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  • (PMID = 16519582.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / Vimentin
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9. Lordick F: [Multidisciplinary treatment for adult soft tissue sarcoma]. Chirurg; 2009 Mar;80(3):209-15
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  • [Title] [Multidisciplinary treatment for adult soft tissue sarcoma].
  • The current standard in local treatment of soft tissue sarcomas has shifted from amputation and similar mutilating resections to more organ- and function-preserving surgery.
  • Progress may occur when the pathogenesis and molecular profile of specific sarcoma subtypes are better understood, allowing more effective new drugs.
  • Presently the most effective measure to improve the prognosis with soft tissue sarcomas is early patient referral to expert centres, where diagnostic workup and therapy decisions are made on a multidisciplinary basis and updated according to the newest guidelines and study results.
  • [MeSH-major] Patient Care Team. Sarcoma / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adult. Child. Combined Modality Therapy. Cooperative Behavior. Disease-Free Survival. Humans. Interdisciplinary Communication. Neoadjuvant Therapy. Neoplasm Staging. Prognosis

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  • (PMID = 19156392.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 50
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10. Sampath S, Hitchcock YJ, Shrieve DC, Randall RL, Schultheiss TE, Wong JY: Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sarcoma: multi-institutional analysis of 261 patients. J Surg Oncol; 2010 Apr 1;101(5):345-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sarcoma: multi-institutional analysis of 261 patients.
  • BACKGROUND AND OBJECTIVE: To examine the impact of adjuvant radiotherapy (RT) and surgical technique on survival in retroperitoneal soft-tissue sarcoma.
  • [MeSH-major] Retroperitoneal Neoplasms / therapy. Sarcoma / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Retrospective Studies. Treatment Failure


11. Gronchi A, Miceli R, Fiore M, Collini P, Lozza L, Grosso F, Mariani L, Casali PG: Extremity soft tissue sarcoma: adding to the prognostic meaning of local failure. Ann Surg Oncol; 2007 May;14(5):1583-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extremity soft tissue sarcoma: adding to the prognostic meaning of local failure.
  • BACKGROUND: We explored the prognostic meaning of local relapse and surgical margins in adult soft tissue sarcoma of the extremities.
  • METHODS: Out of a series of 1017 patients with extremity soft tissue sarcoma treated over 20 years, we picked a group of 238 patients operated on at our institution for their first local relapse: 88 after their primary operation performed at the same center and 150 elsewhere.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Lower Extremity / pathology. Male. Middle Aged. Neoplasm Metastasis / pathology. Prognosis. Survival Rate. Treatment Failure. Upper Extremity / pathology

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  • [CommentIn] Ann Surg Oncol. 2007 May;14(5):1528-9 [17295083.001]
  • (PMID = 17260106.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Rutkowski P, Nowecki ZI, Zdzienicki M, Michej W, Symonides M, Rosinska M, Dziewirski W, Bylina E, Ruka W: Cutaneous melanoma with nodal metastases in elderly people. Int J Dermatol; 2010 Aug;49(8):907-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Incidence. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Prognosis. Sex Distribution. Young Adult

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  • [Copyright] © 2010 The International Society of Dermatology.
  • (PMID = 21174374.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Wang CN, An XJ, Shi QL, Xu Y, Zhou XJ, Li NY, Zhou HB, Ma HH: [Clinicopathological study of 5 cases of proximal-type epithelioid sarcoma]. Zhonghua Bing Li Xue Za Zhi; 2009 May;38(5):298-301
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  • [Title] [Clinicopathological study of 5 cases of proximal-type epithelioid sarcoma].
  • OBJECTIVE: To investigate the clinicopathological characteristics, diagnosis and differential diagnoses of proximal-type epithelioid sarcoma (PES).
  • [MeSH-major] Pelvic Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Vimentin / metabolism. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mucin-1 / metabolism. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Young Adult. beta Catenin / metabolism


14. Chung PW, Deheshi BM, Ferguson PC, Wunder JS, Griffin AM, Catton CN, Bell RS, White LM, Kandel RA, O'Sullivan B: Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a comparison with other soft tissue sarcomas. Cancer; 2009 Jul 15;115(14):3254-61
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  • [Title] Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a comparison with other soft tissue sarcomas.
  • BACKGROUND: Myxoid liposarcoma has been reported to be more radiosensitive compared with other soft tissue sarcomas (STS).
  • The authors report the results of multidisciplinary treatment of extremity myxoid liposarcoma compared with a contemporary cohort of other STS subtypes with an emphasis on the role of radiotherapy (RT) in improving local control.
  • METHODS: Between 1989 and 2004, 691 patients were identified from a prospective STS database who underwent combined management for localized extremity STS and were followed for a minimum of 12 months or until death.
  • Demographics and outcomes were compared between patients with myxoid liposarcoma and other STS subtypes (other-STS).
  • RESULTS: Of 691 patients, 88 patients had myxoid liposarcoma and 603 had other STS subtypes (other-STS).
  • Median age was 48 and 60 years for the myxoid liposarcoma and other-STS groups, respectively.
  • For myxoid liposarcoma and other-STS groups, preoperative RT was used in 57% versus 61% of patients and postoperative RT in 43% versus 39%, respectively.
  • The 5-year local recurrence-free survival was 97.7% for patients with myxoid liposarcoma compared with 89.6% for patients with other-STS tumors (P = .008).
  • High-grade tumors were present in 7% and 59% of myxoid liposarcoma and other-STS patients, respectively (P = .0003).
  • Two myxoid liposarcoma patients with local recurrence had positive resection margins, whereas only 33% of patients in the other-STS group who developed a local recurrence had positive resection margins.
  • No patients with myxoid liposarcoma required amputation as primary management, whereas 8 (1.3%) required amputation as primary management in the other-STS group.
  • Systemic disease control was superior in myxoid liposarcoma compared with other-STS patients, with 5-year overall and metastasis-free survival rates of 93.9% versus 76.4% (P = .0008) and 89.1% versus 66.0% (P = .0001) respectively.
  • In comparison, 205 (34%) patients with other-STS tumors developed systemic disease but 78% had pulmonary metastases.
  • CONCLUSIONS: Multidisciplinary management of extremity STS achieves high rates of local control.
  • Myxoid liposarcoma is associated with higher rates of local control compared with other STS subtypes, after combined surgery and radiation, suggesting a particular radiosensitivity that can be exploited to improve oncologic outcome in appropriate cases.
  • [MeSH-major] Extremities. Liposarcoma, Myxoid / radiotherapy. Sarcoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis. Treatment Outcome


15. Campanacci DA, Scoccianti G, Beltrami G, Mugnaini M, Capanna R: Ankle arthrodesis with bone graft after distal tibia resection for bone tumors. Foot Ankle Int; 2008 Oct;29(10):1031-7
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  • BACKGROUND: Treatment of distal tibial tumors is challenging due to the scarce soft tissue coverage of this area.
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Nails. Bone Plates. Female. Fibula / transplantation. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Hemangioendothelioma / surgery. Histiocytoma, Benign Fibrous / surgery. Humans. Ilium / transplantation. Limb Salvage. Male. Middle Aged. Pain Measurement. Postoperative Complications. Retrospective Studies. Sarcoma / surgery. Transplantation, Autologous. Transplantation, Homologous. Treatment Outcome

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  • (PMID = 18851821.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Ivanov SM, Tkachev SI, Bokhian BIu, Petrovichev NN, Karapetian RM, Machak GN, Nazarenko AV: [Thermoradiochemotherapy of inoperable soft-tissue sarcoma]. Vopr Onkol; 2005;51(3):350-4
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  • [Title] [Thermoradiochemotherapy of inoperable soft-tissue sarcoma].
  • Three groups of patients with inoperable soft-tissue sarcoma received preoperative radiotherapy (57), thermoradiotherapy (102) and thermoradiochemotherapy (16) (n=175).
  • [MeSH-major] Hyperthermia, Induced. Neoadjuvant Therapy / methods. Sarcoma / drug therapy. Sarcoma / radiotherapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant / methods. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Radiotherapy, Adjuvant / methods. Treatment Outcome

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  • (PMID = 16279101.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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17. Cahlon O, Spierer M, Brennan MF, Singer S, Alektiar KM: Long-term outcomes in extremity soft tissue sarcoma after a pathologically negative re-resection and without radiotherapy. Cancer; 2008 Jun 15;112(12):2774-9
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  • [Title] Long-term outcomes in extremity soft tissue sarcoma after a pathologically negative re-resection and without radiotherapy.
  • BACKGROUND: The purpose was to define the rate of local recurrence (LR) and identify prognostic factors for LR in patients with extremity soft-tissue sarcoma (STS) treated with limb-sparing surgery and a pathologically negative re-resection specimen without radiotherapy (RT).
  • METHODS: A review of the prospective sarcoma database identified 200 patients with primary, nonmetastatic, extremity STS treated with limb-sparing surgery between June 1982 and December 2002 who had a pathologically confirmed negative re-resection.
  • [MeSH-major] Extremities / surgery. Neoplasm Recurrence, Local / pathology. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Disease-Free Survival. Feasibility Studies. Humans. Middle Aged. Radiotherapy, Adjuvant. Reoperation. Survival Rate

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  • [Copyright] Copyright (c) 2008 American Cancer Society.
  • (PMID = 18429001.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Niimi R, Matsumine A, Kusuzaki K, Kuratsu S, Araki N, Aoki Y, Ueda T, Kudawara I, Myoui A, Ieguchi M, Hashimoto N, Yoshikawa H, Uchida A: Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg. J Cancer Res Clin Oncol; 2008 Oct;134(10):1087-95
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  • [Title] Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg.
  • PURPOSE: The usefulness of limb salvage surgery for distal lower leg sarcoma remains controversial.
  • We analyzed the long-term prognosis, limb function, and complications after limb salvage treatment of patients with distal lower leg sarcoma.
  • METHODS: Ten patients treated with limb salvage surgery for primary distal lower leg sarcoma were retrospectively reviewed.
  • CONCLUSIONS: Despite the high rate of complications, patients treated with limb salvage surgery for the distal lower leg sarcoma revealed excellent final functional results without impairing the oncologic results.
  • Limb salvage surgery is therefore considered to be an effective treatment option for distal lower leg sarcoma when adequate informed consent can be obtained from the patient.
  • [MeSH-major] Bone Neoplasms / surgery. Leg / surgery. Limb Salvage. Postoperative Complications. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis

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  • (PMID = 18386057.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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19. Morii T, Yoshiyama A, Morioka H, Anazawa U, Mochizuki K, Yabe H: Clinical significance of magnetic resonance imaging in the preoperative differential diagnosis of calcifying aponeurotic fibroma. J Orthop Sci; 2008 May;13(3):180-6
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  • CONCLUSIONS: MRI revealed several features that can contribute to the preoperative differential diagnosis of calcifying aponeurotic fibroma from other fibrous tumors, giant cell tumor of the tendon sheath, or soft tissue sarcoma.
  • [MeSH-major] Calcinosis / pathology. Fibroma / pathology. Magnetic Resonance Imaging. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Ankle / pathology. Child. Child, Preschool. Cohort Studies. Female. Hand / pathology. Humans. Male

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  • (PMID = 18528649.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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20. Matthews A, Tang M, Cooper K: Cytogenetic aberrations in soft tissue tumors harvested from fresh tissue submitted for surgical pathology: a single institutional experience. Int J Surg Pathol; 2010 Aug;18(4):260-7
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  • [Title] Cytogenetic aberrations in soft tissue tumors harvested from fresh tissue submitted for surgical pathology: a single institutional experience.
  • AIMS: Recurrent cytogenetic abnormalities have been reported in many types of soft tissue neoplasms, and the detection of these aberrations imparts diagnostic utility.
  • The aim of this study is to demonstrate that classical karyotyping may be performed with minimal effort as an adjunct to surgical pathology on fresh tissue submitted for histopathological examination.
  • To the authors' knowledge, there are no recently published reviews in the literature in English of cytogenetic abnormalities in soft tissue tumors from a single institution.
  • METHODS: Conventional metaphase cytogenetics was performed in the authors' cytogenetics laboratory on fresh tissue from mesenchymal tumors from their surgical pathology laboratory over a period of 4 years.
  • Cytogenetics reports, clinical history, and histopathology were reviewed for 48 soft tissue tumors.
  • RESULTS: The authors reviewed 48 cases of benign and malignant soft tissue tumors, which included 28 distinct morphologies.
  • [MeSH-major] Chromosome Aberrations. Pathology, Surgical / methods. Sarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Karyotyping. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult

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  • (PMID = 19776087.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Thway K, Fisher C, Debiec-Rychter M, Calonje E: Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum Pathol; 2009 Nov;40(11):1586-90
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  • [Title] Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma.
  • Low-grade fibromyxoid sarcoma is a soft tissue sarcoma with recurrent and low metastatic potential, which has characteristic FUS-CREB3L2 or FUS-CREB3L1 fusions.
  • Low-grade fibromyxoid sarcoma and perineurioma can appear morphologically similar, particularly in small biopsy specimens, and distinction between the 2 entities is important for appropriate treatment.
  • Low-grade fibromyxoid sarcoma is negative for most immunohistochemical markers, whereas perineuriomas stain variably for epithelial membrane antigen, CD34 and claudin-1, a tight-junction associated protein.
  • We studied 15 cases of genetically proven low-grade fibromyxoid sarcoma that at least focally resembled perineurioma, with antibodies to claudin-1 and epithelial membrane antigen.
  • This has implications toward the accurate diagnosis of both tumors, and, as positivity for claudin-1 in low-grade fibromyxoid sarcoma is not previously documented, suggests that there might be underdiagnosis of low-grade fibromyxoid sarcoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Fibrosarcoma / pathology. Membrane Proteins / biosynthesis. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Claudin-1. Diagnosis, Differential. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Mucin-1 / biosynthesis. Young Adult

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  • (PMID = 19540561.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Membrane Proteins; 0 / Mucin-1
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22. Hartmann JT, Patel S: Recent developments in salvage chemotherapy for patients with metastatic soft tissue sarcoma. Drugs; 2005;65(2):167-78
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  • [Title] Recent developments in salvage chemotherapy for patients with metastatic soft tissue sarcoma.
  • The number of effective cytotoxic agents for the treatment of patients with metastatic adult soft tissue sarcoma is limited, especially when patients have failed anthracycline- and ifosfamide-based chemotherapy.
  • Small round cell tumours (SRCTs), such as Ewing's sarcoma/primitive neuroectodermal tumour, desmoplastic SRCT and rhabdomyosarcoma, are chemotherapy-sensitive and potentially curable malignancies, which are treated with multimodality, dose-intensive, neoadjuvant protocols regardless of size or overt metastatic disease.
  • Most other high-grade (grading >I), so-called 'adult type', soft tissue sarcomas such as fibrosarcoma, liposarcoma, pleomorphic and synovial sarcomas are treated with an anthracycline-based regimen with or without ifosfamide as front-line therapy.
  • In relapsed 'adult type' soft tissue sarcomas, trofosfamide, gemcitabine and trabectedin (ecteinascidin 743) appear to be drugs associated with some activity and an acceptable toxicity profile.
  • A high activity has been reported for the taxanes, in particular for paclitaxel, in vascular sarcomas located in the scalp or face and in Kaposi's sarcoma.
  • It is interesting to note that the different drugs have particular effects in distinct subtypes of soft tissue sarcoma; however, it should be taken into account that the number of patients included in the phase II trials is limited.
  • Targeted therapy inhibiting vascular endothelial growth factor receptor, epidermal growth factor receptor, RAF kinase, c-KIT or platelet-derived growth factor receptors will continue to be tested in GIST patients refractory to imatinib and in other sarcoma histologies.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Neoplasm Metastasis / drug therapy. Salvage Therapy. Sarcoma / drug therapy. Sarcoma / pathology


23. Indelicato DJ, Keole SR, Shahlaee AH, Shi W, Morris CG, Gibbs CP Jr, Scarborough MT, Marcus RB Jr: Impact of local management on long-term outcomes in Ewing tumors of the pelvis and sacral bones: the University of Florida experience. Int J Radiat Oncol Biol Phys; 2008 Sep 1;72(1):41-8
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  • The patients who received RT alone were more likely to be older men with larger tumors exhibiting soft-tissue extension.
  • [MeSH-major] Pelvic Bones. Sacrum. Sarcoma, Ewing / radiotherapy. Sarcoma, Ewing / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy / methods. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 18234436.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Gortzak Y, Lockwood GA, Mahendra A, Wang Y, Chung PW, Catton CN, O'Sullivan B, Deheshi BM, Wunder JS, Ferguson PC: Prediction of pathologic fracture risk of the femur after combined modality treatment of soft tissue sarcoma of the thigh. Cancer; 2010 Mar 15;116(6):1553-9
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  • [Title] Prediction of pathologic fracture risk of the femur after combined modality treatment of soft tissue sarcoma of the thigh.
  • BACKGROUND: The objective of the current study was to formulate a scoring system to enable decision making for prophylactic stabilization of the femur after surgical resection of a soft tissue sarcoma (STS) of the thigh.
  • The study group included 22 patients who developed a radiation-related pathological fracture of the femur after surgery and radiotherapy for an STS of the thigh.
  • CONCLUSIONS: Radiation-related fractures of the femur after combined surgery and radiotherapy for STS are uncommon, but are difficult to manage and their nonunion rate is extremely high.
  • [MeSH-major] Combined Modality Therapy / adverse effects. Femur. Fractures, Spontaneous / complications. Sarcoma / complications. Thigh
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Logistic Models. Male. Middle Aged. Nomograms. Prognosis. Radiotherapy Dosage. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 20108335.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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25. Eyesan SU, Obalum DC, Onovo DO, Ketiku KK, Abdulkareem FB: Clinico-pathologic patterns of extremity liposarcoma. Niger Postgrad Med J; 2010 Mar;17(1):27-9
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  • RESULTS: Liposarcoma accounted for 6 [27.3%] of 22 cases of soft tissue sarcomas seen within the study period.
  • CONCLUSION: Liposarcoma is the commonest extremity soft tissue sarcoma seen in our centre, the myxoid type being the commonest histologic subtype.
  • [MeSH-major] Liposarcoma / pathology. Liposarcoma / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Extremities. Follow-Up Studies. Hospitals, Special. Humans. Male. Middle Aged. Neoplasm Staging. Nigeria. Orthopedics. Prospective Studies. Radiotherapy, Adjuvant. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 20348979.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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26. Carpentieri DF, Qualman SJ, Bowen J, Krausz T, Marchevsky A, Dickman PS, Cancer Committee, College of American Pathologists: Protocol for the examination of specimens from pediatric and adult patients with osseous and extraosseous ewing sarcoma family of tumors, including peripheral primitive neuroectodermal tumor and ewing sarcoma. Arch Pathol Lab Med; 2005 Jul;129(7):866-73
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  • [Title] Protocol for the examination of specimens from pediatric and adult patients with osseous and extraosseous ewing sarcoma family of tumors, including peripheral primitive neuroectodermal tumor and ewing sarcoma.
  • [MeSH-major] Bone Neoplasms / classification. Clinical Protocols. Neuroectodermal Tumors, Primitive, Peripheral / classification. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Sarcoma, Ewing / classification. Sarcoma, Ewing / pathology. Soft Tissue Neoplasms / classification
  • [MeSH-minor] Adult. Child. Humans

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  • (PMID = 15974809.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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27. Doglietto GB, Tortorelli AP, Papa V, Rosa F, Bossola M, Prete FP, Covino M, Pacelli F: Giant retroperitoneal sarcomas: a single institution experience. World J Surg; 2007 May;31(5):1047-54
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  • BACKGROUND: Retroperitoneal sarcomas (RS) are a rare group of malignant soft-tissue tumors; due to the flexibility of the retroperitoneum, they generally grow to a large size before becoming symptomatic, often involving surrounding structures.
  • [MeSH-major] Retroperitoneal Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Prognosis. Proportional Hazards Models. Survival Analysis. Treatment Outcome

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  • (PMID = 17345124.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Rutkowski P, Nowecki ZI, Zurawski Z, Dziewirski W, Nasierowska-Guttmejer A, Switaj T, Ruka W: In transit/local recurrences in melanoma patients after sentinel node biopsy and therapeutic lymph node dissection. Eur J Cancer; 2006 Jan;42(2):159-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16324835.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Zalcberg JR, Verweij J, Casali PG, Le Cesne A, Reichardt P, Blay JY, Schlemmer M, Van Glabbeke M, Brown M, Judson IR, EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group, Australasian Gastrointestinal Trials Group: Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur J Cancer; 2005 Aug;41(12):1751-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Benzamides. Cross-Over Studies. Disease Progression. Dose-Response Relationship, Drug. Feasibility Studies. Female. Humans. Imatinib Mesylate. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16098458.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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30. Hwang S, Lefkowitz R, Landa J, Akin O, Schwartz LH, Cassie C, Healey JH, Alektiar KM, Panicek DM: Local changes in bone marrow at MRI after treatment of extremity soft tissue sarcoma. Skeletal Radiol; 2009 Jan;38(1):11-9
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  • [Title] Local changes in bone marrow at MRI after treatment of extremity soft tissue sarcoma.
  • OBJECTIVE: To determine the prevalence and appearance of magnetic resonance imaging (MRI) signal changes that occur in local bone marrow after radiation therapy (RT) and/or chemotherapy for extremity soft tissue sarcoma (STS).
  • MATERIALS AND METHODS: Seventy patients with primary STS at the level of a long bone who also had undergone pretreatment MRI and at least one post-treatment MRI of the tumor bed were identified.
  • CONCLUSION: Changes in MRI appearance of long bone marrow frequently are evident after combined RT and chemotherapy for STS and most commonly increase or fluctuate in size over time.
  • [MeSH-major] Bone Marrow / pathology. Magnetic Resonance Imaging / methods. Sarcoma / drug therapy. Sarcoma / radiotherapy. Soft Tissue Neoplasms / drug therapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Contrast Media. Disease Progression. Extremities. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18704399.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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31. Lucas DR, Kshirsagar MP, Biermann JS, Hamre MR, Thomas DG, Schuetze SM, Baker LH: Histologic alterations from neoadjuvant chemotherapy in high-grade extremity soft tissue sarcoma: clinicopathological correlation. Oncologist; 2008 Apr;13(4):451-8
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  • [Title] Histologic alterations from neoadjuvant chemotherapy in high-grade extremity soft tissue sarcoma: clinicopathological correlation.
  • Histologic response to chemotherapy is generally regarded as an independent prognostic variable in bone sarcomas, both osteosarcoma and Ewing's sarcoma.
  • In soft tissue sarcomas, however, descriptions of histologic alterations from chemotherapy and correlative outcome studies are much more limited.
  • Herein we report clinicopathological findings from a homogeneously treated group of 31 patients with tumor stage T2 grade 3 extremity soft tissue sarcomas treated with the same neoadjuvant chemotherapy followed by surgical excision, treated by the same medical oncologist and orthopedic surgeon.
  • Chemotherapy induces profound tissue alterations in soft tissue sarcomas.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoadjuvant Therapy. Sarcoma / drug therapy. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Disease-Free Survival. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Male. Middle Aged. Prognosis. Prospective Studies. Treatment Outcome


32. Ben Hamida KS, Bouhaouala MH, Derbel F, Ksontini I, Rahali H, Ennouri K, Dougui MH: Clear cell sarcoma: a rare entity within melanoma. Joint Bone Spine; 2009 Jul;76(4):430-1
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  • [Title] Clear cell sarcoma: a rare entity within melanoma.
  • [MeSH-major] Melanoma / diagnosis. Sarcoma, Clear Cell / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Ankle Joint. Fatal Outcome. Foot. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19560955.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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33. Petera J, Neumanová R, Odrazka K, Ondrak M, Prochazka E: Perioperative hyperfractionated high-dose rate brachytherapy combined with external beam radiotherapy in the treatment of soft tissue sarcomas. Tumori; 2005 Jul-Aug;91(4):331-4
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  • [Title] Perioperative hyperfractionated high-dose rate brachytherapy combined with external beam radiotherapy in the treatment of soft tissue sarcomas.
  • AIMS AND BACKGROUND: Low-dose rate brachytherapy alone or in combination with external beam radiotherapy represents a well-established adjuvant treatment in soft tissue sarcomas following surgical resection.
  • The purpose of our study was an evaluation of the viability of perioperative hyperfractionated high-dose rate brachytherapy in combination with external beam radiotherapy for primary and recurrent soft tissue sarcomas.
  • PATIENTS AND METHODS: From February 1998 through June 2002, 10 adult patients with soft tissue sarcomas were treated by interstitial perioperative high-dose rate brachytherapy and external beam radiotherapy.
  • CONCLUSIONS: Our study on a small number of patients suggests that perioperative hyperfractionated high-dose rate brachytherapy with doses 8 x 3 Gy in combination with external beam radiotherapy 40-50 Gy is a promising method to achieve high biological doses in the postoperative radiotherapy of soft tissue sarcomas without severe late morbidity and warrants further research.
  • [MeSH-major] Brachytherapy / methods. Neoplasm Recurrence, Local / radiotherapy. Sarcoma / radiotherapy
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Humans. Iridium Radioisotopes / therapeutic use. Male. Middle Aged. Perioperative Care / methods. Radiotherapy Dosage. Radiotherapy, Adjuvant / methods. Treatment Outcome

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  • (PMID = 16277099.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iridium Radioisotopes
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34. Ramseier LE, Dumont CE, Bode-Lesniewska B, Lombriser N, Exner GU: Results of treatment of malignant soft tissue tumours in the groin. Scand J Plast Reconstr Surg Hand Surg; 2008;42(5):241-5
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  • [Title] Results of treatment of malignant soft tissue tumours in the groin.
  • Soft tissue sarcomas of the inguinal region are a challenge with regard to achieving clear margins, reconstruction of the femoral vessels, and soft tissue coverage.
  • Six men aged 39 to 48 years and one woman of 56 were treated for soft tissue sarcomas of the groin.
  • In two patients the soft tissue defect was covered primarily with an ipsilateral rectus abdominis muscle flap, in two others (because of wound dehiscence) coverage was achieved with the opposite rectus abdominis muscle pedicle flap as we were afraid of closure of the ipsilateral deep epigastric vessels.
  • A high rate of local tumour control in soft tissue sarcomas of the inguinal region can be achieved with the combination of surgical resection and radiotherapy.
  • No compromise should be made with aggressive soft tissue coverage to protect the vascular reconstruction, control wound healing after neoadjuvant radiotherapy, or allow immediate adjuvant radiotherapy.

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  • (PMID = 18821449.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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35. Grünhagen DJ, de Wilt JH, Verhoef C, van Geel AN, Eggermont AM: TNF-based isolated limb perfusion in unresectable extremity desmoid tumours. Eur J Surg Oncol; 2005 Oct;31(8):912-6
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  • BACKGROUND: Desmoid tumours are soft tissue sarcomas with local aggressive behaviour and a high rate of local recurrence after treatment.
  • As isolated limb perfusion (ILP) with TNF and melphalan has proven to be extremely effective in the treatment of soft tissue sarcoma, we studied its potential in locally advanced extremity desmoid tumours.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Chemotherapy, Cancer, Regional Perfusion. Dermoid Cyst / drug therapy. Lower Extremity / pathology. Melphalan / administration & dosage. Soft Tissue Neoplasms / drug therapy. Tumor Necrosis Factor-alpha / administration & dosage. Upper Extremity / pathology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease Progression. Female. Humans. Limb Salvage. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Prospective Studies. Remission Induction. Treatment Outcome

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  • (PMID = 16098709.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Tumor Necrosis Factor-alpha; Q41OR9510P / Melphalan
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36. Friedrichs N, Küchler J, Endl E, Koch A, Czerwitzki J, Wurst P, Metzger D, Schulte JH, Holst MI, Heukamp LC, Larsson O, Tanaka S, Kawai A, Wardelmann E, Buettner R, Pietsch T, Hartmann W: Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. J Pathol; 2008 Dec;216(4):428-39
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  • [Title] Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma.
  • Synovial sarcomas account for 5-10% of all soft tissue sarcomas and the majority of synovial sarcomas display characteristic t(X;18) translocations that result in enhanced transcription of the insulin-like growth factor-2 (IGF-2) gene.
  • To analyse the functional and potential therapeutic relevance of IGF-1R signalling, synovial sarcoma cell lines were treated with the IGF-1R inhibitor NVP-AEW541.
  • Finally, synovial sarcoma cell migration was found to be dependent on signals transmitted by the IGF-1R.
  • [MeSH-major] Receptor, IGF Type 1 / physiology. Sarcoma, Synovial / metabolism. Signal Transduction / physiology
  • [MeSH-minor] Adult. Antineoplastic Agents / pharmacology. Apoptosis. Blotting, Western / methods. Cell Line, Tumor. Cell Movement / drug effects. Cell Proliferation / drug effects. Female. Fluorescent Antibody Technique. Humans. Insulin-Like Growth Factor II / genetics. Insulin-Like Growth Factor II / metabolism. MAP Kinase Signaling System / physiology. Male. Middle Aged. Phosphatidylinositol 3-Kinases / metabolism. Phosphorylation. Proto-Oncogene Proteins c-akt / metabolism. Pyrimidines / pharmacology. Pyrroles / pharmacology. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 18855347.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / NVP-AEW541; 0 / Pyrimidines; 0 / Pyrroles; 0 / RNA, Messenger; 67763-97-7 / Insulin-Like Growth Factor II; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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37. Blaes AH, Lindgren B, Mulrooney DA, Willson L, Cho LC: Pathologic femur fractures after limb-sparing treatment of soft-tissue sarcomas. J Cancer Surviv; 2010 Dec;4(4):399-404
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  • [Title] Pathologic femur fractures after limb-sparing treatment of soft-tissue sarcomas.
  • METHODS: Patients treated for a soft tissue sarcoma of the thigh with limb-sparing surgery and radiation therapy between 1986 and 2000 at the University of Minnesota Masonic Cancer Center (n=89) were identified.
  • IMPLICATIONS FOR CANCER SURVIVORS: Survivors of soft tissue sarcomas of the femur may be at risk for the development of femur fractures and warrant close observation.
  • [MeSH-major] Bone Neoplasms / therapy. Femoral Fractures / etiology. Sarcoma / complications. Sarcoma / therapy. Soft Tissue Neoplasms / complications. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures / methods. Minimally Invasive Surgical Procedures / rehabilitation. Radiotherapy, Conformal / methods. Retrospective Studies. Risk Factors. Thigh / pathology. Thigh / radiation effects. Thigh / surgery. Young Adult

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  • (PMID = 20827514.001).
  • [ISSN] 1932-2267
  • [Journal-full-title] Journal of cancer survivorship : research and practice
  • [ISO-abbreviation] J Cancer Surviv
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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38. Bedre G, Gupta T, Rajasekharan P, Munshi A, Jalali R: Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns? JOP; 2007;8(4):444-9
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  • [Title] Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns?
  • CONTEXT: Soft tissue sarcomas generally first metastasize to the lungs followed by the involvement of other sites such as lymph nodes and bones as part of the disseminated disease.
  • Cerebellar and pancreatic metastases from tumors of mesenchymal origin such as soft tissue sarcomas are exceptional, more so in the absence of pulmonary metastases.
  • CASE REPORT: A previously treated case of chest wall sarcoma presented with the sudden onset of neurological symptoms.
  • A metastasectomy of the solitary brain lesion confirmed a deposit from a previously treated sarcoma.
  • A CT-guided biopsy was suggestive of high-grade sarcoma.
  • CONCLUSION: Cerebellar, pancreatic, and paraspinal metastases from soft tissue sarcomas are rare, especially in the absence of pulmonary metastases.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Pancreatic Neoplasms / secondary. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17625297.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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39. Bhurgri Y, Bhurgri H, Pervez S, Kayani N, Usman A, Bashir I, Bhurgri A, Hasan SH, Zaidi SM: Epidemiology of soft tissue sarcomas in Karachi South, Pakistan (1995-7). Asian Pac J Cancer Prev; 2008 Oct-Dec;9(4):709-14
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  • [Title] Epidemiology of soft tissue sarcomas in Karachi South, Pakistan (1995-7).
  • INTRODUCTION: The present study was conducted with the objective of examining epidemiological characteristics of soft tissue sarcomas (STSs) in Karachi.
  • PATIENTS AND METHODS: Epidemiological data of 96 (63 male and 33 female) incident STS cases registered at Karachi Cancer Registry (KCR) for Karachi South (KS), from 1st January 1995 to 31st December 1997, were reviewed.
  • In males, 8 (12.7%) STS cases were diagnosed in the pediatric age group (0-14), 12 (19.1%) in adolescents and young adults (15-24 years), 19 (30.1%) in adults 25-49 years of age and 24 (38.1%) in the 50 years+ age group.
  • CONCLUSION: Karachi falls into a high risk region for STS, observed in a relatively younger population, with a male predominance, high frequency of rhabdomyosarcoma and advanced stage at diagnosis.
  • [MeSH-major] Sarcoma / epidemiology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Developing Countries. Female. Humans. Male. Middle Aged. Neoplasm Staging. Pakistan / epidemiology. Prevalence. Prognosis. Registries. Retrospective Studies. Sex Distribution. Survival Analysis. Young Adult

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  • (PMID = 19256764.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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40. Kawai A, Hosono A, Nakayama R, Matsumine A, Matsumoto S, Ueda T, Tsuchiya H, Beppu Y, Morioka H, Yabe H, Japanese Musculoskeletal Oncology Group: Clear cell sarcoma of tendons and aponeuroses: a study of 75 patients. Cancer; 2007 Jan 1;109(1):109-16
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  • [Title] Clear cell sarcoma of tendons and aponeuroses: a study of 75 patients.
  • BACKGROUND: Clear cell sarcoma (CCS) of tendons and aponeuroses (malignant melanoma of soft parts) is a rare melanocytic soft tissue sarcoma.
  • [MeSH-major] Sarcoma, Clear Cell / pathology. Sarcoma, Clear Cell / therapy. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / therapy. Tendons
  • [MeSH-minor] Adult. Female. Humans. Male. Melanoma / mortality. Melanoma / pathology. Melanoma / therapy. Multivariate Analysis. Neoplasm Metastasis. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 17133413.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Fernebro J, Carneiro A, Rydholm A, Domanski HA, Karlsson A, Borg A, Nilbert M: Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma. Sarcoma; 2008;2008:431019
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  • [Title] Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma.
  • Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult.
  • Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients.
  • In an unsupervised hierarchical cluster analysis, similar genomic profiles and close clustering between the first and subsequent STS were identified in 5 cases, suggesting metastatic disease, whereas the tumors from the remaining 8 patients did not cluster and showed only weak pairwise correlation, suggesting development of second primary STS.
  • Discussion. The similarities and dissimilarities identified in the first and second STS suggest that genetic profiles can be used to distinguish soft tissue metastases from second primary STS.
  • The demonstration of genetically different soft tissue sarcomas in the same patient suggests independent tumor origin and serves as a reminder to consider development of second primary STS, which has prognostic and therapeutic implications.

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  • (PMID = 19197386.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2634844
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42. Billings SD, Giblen G, Fanburg-Smith JC: Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population. Am J Surg Pathol; 2005 Feb;29(2):204-10
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  • [Title] Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population.
  • Low-grade fibromyxoid sarcoma (LGFMS), usually a deeply situated mass in adults, is uncommon in superficial soft tissue and in children.
  • Clinical and histologic submitting diagnoses were mainly benign except for 3 cases, submitted as low-grade sarcoma, with only one as superficial LGFMS.
  • [MeSH-major] Fibroma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15644777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Pfannschmidt J, Geisbüsch P, Muley T, Dienemann H, Hoffmann H: Surgical treatment of primary soft tissue sarcomas involving the chest: experiences in 25 patients. Thorac Cardiovasc Surg; 2006 Apr;54(3):182-7
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  • [Title] Surgical treatment of primary soft tissue sarcomas involving the chest: experiences in 25 patients.
  • BACKGROUND: Primary soft tissue sarcomas of the chest wall are uncommon and data concerning treatment and results are sparse.
  • METHODS: Retrospective review of our database identified 25 patients (12 men, 13 women) who underwent chest wall resection for primary soft tissue sarcoma during the 18-year study period (January 1984 through to January 2002).
  • CONCLUSIONS: Chest wall resections in primary soft tissue sarcomas can be accomplished safely with a low mortality rate.
  • Long-term survival can be achieved for primary soft tissue sarcomas but histological grading is of prognostic significance.
  • [MeSH-major] Sarcoma / surgery. Thoracic Neoplasms / surgery. Thoracic Surgical Procedures. Thoracic Wall / pathology. Thoracic Wall / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Forced Expiratory Volume. Humans. Length of Stay. Male. Middle Aged. Neoplasm Staging. Patient Selection. Retrospective Studies. Ribs / surgery. Spirometry. Sternum / surgery. Surgical Flaps. Survival Analysis. Treatment Outcome. Tumor Burden. Vital Capacity

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  • (PMID = 16639680.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Lahl M, Fisher VL, Laschinger K: Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship. Clin J Oncol Nurs; 2008 Feb;12(1):89-97
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  • [Title] Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship.
  • The Ewing's sarcoma family of tumors (ESFT) is a malignant primary bone tumor often involving soft tissue that affects not only children but also young adults.
  • ESFT, which includes Ewing's sarcoma, extraosseous Ewing's sarcoma, Askin tumor, and primitive neuroectodermal tumor, is the second most common primary malignant bone tumor in children and adolescents.
  • Children and young adults with Ewing's sarcoma face many physical challenges from their illness and the complications of their treatments.
  • [MeSH-major] Bone Neoplasms. Sarcoma, Ewing
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy / adverse effects. Combined Modality Therapy / nursing. Humans. Incidence. Nurse's Role. Oncology Nursing / organization & administration. Prognosis. Radiotherapy, Adjuvant. Risk Factors. Stem Cell Transplantation. Survival Rate. Treatment Outcome

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  • (PMID = 18258578.001).
  • [ISSN] 1092-1095
  • [Journal-full-title] Clinical journal of oncology nursing
  • [ISO-abbreviation] Clin J Oncol Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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45. Kalebi AY, Hale MJ: Pulmonary metastasis from a deltoid subcutaneous low-grade fibromyxoid sarcoma with giant collagen rosettes. Hum Pathol; 2008 Oct;39(10):1553-4; author reply 1554
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  • [Title] Pulmonary metastasis from a deltoid subcutaneous low-grade fibromyxoid sarcoma with giant collagen rosettes.
  • [MeSH-minor] Adult. Collagen. Female. Humans. Muscle, Skeletal / pathology. Soft Tissue Neoplasms / pathology

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  • [CommentOn] Hum Pathol. 2008 Apr;39(4):623-8 [18275982.001]
  • (PMID = 18774378.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
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46. Ward E, Doody O, d'Adhemar C, Swan N, Torreggiani WC: Answer to case of the month #149 alveolar soft-part sarcoma. Can Assoc Radiol J; 2009 Jun;60(3):143-5
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  • [Title] Answer to case of the month #149 alveolar soft-part sarcoma.
  • [MeSH-major] Lung Neoplasms / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Contrast Media. Cough / etiology. Diagnosis, Differential. Fatigue / etiology. Gadolinium. Humans. Image Enhancement / methods. Knee / pathology. Lung / radiography. Magnetic Resonance Imaging. Male. Rare Diseases

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  • (PMID = 19591765.001).
  • [ISSN] 0846-5371
  • [Journal-full-title] Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
  • [ISO-abbreviation] Can Assoc Radiol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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47. Rutkowski P, Nowecki ZI, Michej W, Debiec-Rychter M, Woźniak A, Limon J, Siedlecki J, Grzesiakowska U, Kakol M, Osuch C, Polkowski M, Głuszek S, Zurawski Z, Ruka W: Risk criteria and prognostic factors for predicting recurrences after resection of primary gastrointestinal stromal tumor. Ann Surg Oncol; 2007 Jul;14(7):2018-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Prognosis. Registries. Risk Factors

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  • (PMID = 17473953.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Bode B, Frigerio S, Behnke S, Senn B, Odermatt B, Zimmermann DR, Moch H: Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma. Mod Pathol; 2006 Apr;19(4):541-7
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  • [Title] Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma.
  • To clarify the role of EGFR in synovial sarcoma and to explore the potential for a targeted therapy approach, we have examined 13 of these soft tissue tumors.
  • [MeSH-major] Mutation. Receptor, Epidermal Growth Factor / genetics. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Binding Sites / genetics. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Molecular Sequence Data. Mutation, Missense. Point Mutation. Protein-Tyrosine Kinases / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16514409.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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49. Fletcher CD: The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology; 2006 Jan;48(1):3-12
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  • [Title] The evolving classification of soft tissue tumours: an update based on the new WHO classification.
  • The new WHO classification of soft tissue tumours was introduced in late 2002 and, because it represents a broad consensus view, it has gained widespread acceptance.
  • (ii) the general acceptance that most pleomorphic sarcomas can be meaningfully subclassified and that so-called malignant fibrous histiocytoma is not a definable entity, but instead represents a wastebasket of undifferentiated pleomorphic sarcomas, accounting for no more than 5% of adult soft tissue sarcomas;.
  • (iii) the acknowledgement that most lesions formerly known as haemangiopericytoma show no evidence of pericytic differentiation and, instead, are fibroblastic in nature and form a morphological continuum with solitary fibrous tumour; and (iv) the increasing appreciation that not only do we not know from which cell type(s) most soft tissue tumours originate (histogenesis) but, for many, we do not recognize their line of differentiation or lineage--hence an increasing number of tumours are placed in the "uncertain differentiation" category.
  • [MeSH-major] Sarcoma / classification. Soft Tissue Neoplasms / classification. World Health Organization


50. Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF: Why do patients with low-grade soft tissue sarcoma die? Ann Surg Oncol; 2008 Dec;15(12):3550-60
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  • [Title] Why do patients with low-grade soft tissue sarcoma die?
  • INTRODUCTION: The patterns of failure and mechanisms of sarcoma-specific death are poorly characterized among the minority of patients with low-grade soft tissue sarcoma (STS) who succumb to disease.
  • METHODS: Between 1982 and 2006, 2,041 patients aged >or=16 years with low-grade STS of all sites were treated with curative intent and prospectively followed at a single institution.
  • In 17 patients (9%), the mechanism of sarcoma-related death could not be verified.
  • CONCLUSION: Among patients with low-grade STS, DOD occurs in approximately 9% of patients.

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  • (PMID = 18830667.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA047179-09; United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA 047179; United States / NCI NIH HHS / CA / P01 CA047179-09
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS75337; NLM/ PMC2605207
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51. Potocki K, Prutki M, Kralik M, Hrabak M, Padovan RS: Ewing's sarcoma of the third metatarsal: a case report and review of the literature. Tumori; 2007 Mar-Apr;93(2):210-2
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  • [Title] Ewing's sarcoma of the third metatarsal: a case report and review of the literature.
  • We report a rare case of Ewing's sarcoma involving the third metatarsal bone and spreading into adjacent bone in a 23-year-old man, with special emphasis on imaging characteristics.
  • Computed tomography and magnetic resonance imaging delineated the osseous and soft tissue extent of the tumor.
  • A large soft-tissue mass around the involved bone was highly indicative of Ewing's sarcoma.
  • An early diagnosis of Ewing's sarcoma, even when it occurs in unusual locations, is necessary for adequate treatment and is of particular importance in terms of prognosis.
  • The optimal imaging modality for the diagnosis of Ewing's sarcoma is magnetic resonance imaging since it allows accurate analysis of the soft-tissue component and visualization of possible local invasion of adjacent structures.
  • [MeSH-major] Diagnostic Imaging / methods. Metatarsal Bones / pathology. Sarcoma, Ewing / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Radiography. Tomography, X-Ray Computed

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  • (PMID = 17557573.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Pollock RE: The seminal role of Cancer in our understanding of sarcoma. Cancer; 2008 Oct 1;113(7 Suppl):1969-79
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  • [Title] The seminal role of Cancer in our understanding of sarcoma.
  • The journal Cancer has played a critical role in advancing our understanding of sarcoma, a remarkable cluster of malignancies that arise from tissues of mesenchymal origin throughout the human body and indeed across the entire vertebrate animal spectrum.
  • Approximately equally divided between soft tissue and bone origin, there are greater than 100 recognized histologic subtypes that collectively account for approximately 2% of adult solid tumors.
  • [MeSH-major] Medical Oncology. Periodicals as Topic. Sarcoma / therapy

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  • (PMID = 18798535.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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53. Schwab JH, Boland PJ, Antonescu C, Bilsky MH, Healey JH: Spinal metastases from myxoid liposarcoma warrant screening with magnetic resonance imaging. Cancer; 2007 Oct 15;110(8):1815-22
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  • BACKGROUND: Myxoid liposarcoma (MLS) has an unusual tendency for extrapulmonary metastasis, particularly to the spine and soft tissues.
  • METHODS: Data from patients with had spinal metastases were obtained from the authors' institutional soft tissue sarcoma database.
  • [MeSH-major] Liposarcoma, Myxoid / secondary. Magnetic Resonance Imaging. Soft Tissue Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Positron-Emission Tomography. Predictive Value of Tests. Radiopharmaceuticals. Sensitivity and Specificity. Survival Rate


54. Davidson AW, Hong A, McCarthy SW, Stalley PD: En-bloc resection, extracorporeal irradiation, and re-implantation in limb salvage for bony malignancies. J Bone Joint Surg Br; 2005 Jun;87(6):851-7
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  • [MeSH-major] Bone Neoplasms / radiotherapy. Limb Salvage / methods. Replantation / methods. Sarcoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Female. Femur / radiography. Femur / surgery. Follow-Up Studies. Humans. Humerus / radiography. Humerus / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Pelvic Bones / radiography. Pelvic Bones / surgery. Tibia / radiography. Tibia / surgery. Treatment Outcome

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  • (PMID = 15911672.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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55. Moncrieff MD, Kroon HM, Kam PC, Stalley PD, Scolyer RA, Thompson JF: Isolated limb infusion for advanced soft tissue sarcoma of the extremity. Ann Surg Oncol; 2008 Oct;15(10):2749-56
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  • [Title] Isolated limb infusion for advanced soft tissue sarcoma of the extremity.
  • We report our experience with ILI for the treatment of soft tissue sarcoma (STS).
  • METHODS: From our prospective database, 21 patients with STS of the limb treated with ILI between 1994 and 2007 were identified.
  • ILI is a minimally invasive alternative to isolated limb perfusion for patients with advanced STS of the extremity.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Cancer, Regional Perfusion. Extremities / pathology. Neoplasm Recurrence, Local / drug therapy. Sarcoma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Dactinomycin / administration & dosage. Female. Humans. Male. Melphalan / administration & dosage. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Prognosis. Prospective Studies. Survival Rate

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  • (PMID = 18648882.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; Q41OR9510P / Melphalan
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56. Hawkins DS, Bradfield S, Whitlock JA, Krailo M, Franklin J, Blaney SM, Adamson PC, Reaman G: Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer; 2006 Nov;47(6):790-4
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  • PROCEDURE: Patients with Ewing sarcoma family of tumors (ESFT), osteosarcoma (OS), soft tissue sarcomas (STS), medulloblastoma (MB)/primitive neuroectodermal tumor (PNET), astrocytoma, or neuroblastoma (NB) recurrent or refractory to conventional therapy, measurable disease, and adequate organ function were treated with topotecan 0.3 mg/m2/day by continuous intravenous infusion for 21 consecutive days, followed by 7 days without therapy prior to response assessment.
  • Objective responses were seen in 2/20 patients with ESFT (both partial responses, 4 and 19 courses), 0/10 OS patients, and 0/12 STS patients.
  • [MeSH-major] Astrocytoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Neuroblastoma / drug therapy. Neuroectodermal Tumors, Primitive / drug therapy. Sarcoma / drug therapy. Topotecan / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Dose-Response Relationship, Drug. Fatigue / chemically induced. Female. Humans. Infusions, Intravenous. Male. Maximum Tolerated Dose. Neutropenia / chemically induced. Recurrence. Survival Rate. Thrombocytopenia / chemically induced. Time Factors. Treatment Outcome


57. Jambhekar NA, Bagwan IN, Ghule P, Shet TM, Chinoy RF, Agarwal S, Joshi R, Amare Kadam PS: Comparative analysis of routine histology, immunohistochemistry, reverse transcriptase polymerase chain reaction, and fluorescence in situ hybridization in diagnosis of Ewing family of tumors. Arch Pathol Lab Med; 2006 Dec;130(12):1813-8
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  • OBJECTIVE: To do a comparative analysis of 32 cases with EWS-FLI1: Ewing family of tumors (n = 30), desmoplastic small round cell tumor (n = 1), and undifferentiated sarcoma (n = 1).
  • RESULTS: The 19 male and 13 female patients had bone (n = 19) or soft tissue (n = 13) tumors.
  • Histologic groups were typical Ewing sarcoma (n = 15), atypical Ewing sarcoma (n = 4), Askin Rosai tumors (n = 5), desmoplastic small round cell tumor (n = 1), undifferentiated sarcoma (n = 1), and cases diagnosed as malignant small round cell tumors on FNAC (n = 6).
  • All tumors except desmoplastic small round cell tumor and undifferentiated sarcoma were CD99 positive.
  • EWS-FLI1 by reverse transcriptase polymerase chain reaction was noted in 15 cases of typical Ewing sarcoma, 4 cases of atypical Ewing sarcoma, 5 cases of Askin Rosai tumor, and no cases of desmoplastic small round cell tumor or undifferentiated sarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence. Reverse Transcriptase Polymerase Chain Reaction / methods. Sarcoma, Ewing / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Carcinoma, Small Cell / diagnosis. Child. Child, Preschool. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Oncogene Proteins, Fusion / analysis. Proto-Oncogene Protein c-fli-1 / analysis. RNA-Binding Protein EWS

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  • (PMID = 17149955.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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58. Ahlmann ER, Falkinstein Y, Fedenko AN, Menendez LR: Cryoablation and resection influences patient survival for soft tissue sarcomas: impact on survivorship and local recurrence. Clin Orthop Relat Res; 2007 Jun;459:174-81
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  • [Title] Cryoablation and resection influences patient survival for soft tissue sarcomas: impact on survivorship and local recurrence.
  • Cryosurgical ablation has been used successfully for treating various carcinomas and bone tumors; however, few studies report the use of cryosurgery followed by tumor resection for the treatment of soft tissue sarcomas.
  • We retrospectively reviewed 38 patients with no prior treatment for their neoplasm who underwent cryosurgery followed by wide excision of soft tissue sarcomas.
  • Cryosurgical ablation appears a safe and effective method of devitalizing tumor cells of soft tissue sarcomas.
  • [MeSH-major] Cryosurgery. Neoplasm Recurrence, Local / prevention & control. Sarcoma / mortality. Sarcoma / surgery. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Recovery of Function. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17415009.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Gürkan V, Ozger H: [Sarcomas of the hand]. Acta Orthop Traumatol Turc; 2007 Aug-Oct;41(4):286-90
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  • We evaluated patients who underwent surgical treatment for sarcoma of the hand.
  • METHODS: Between 1990 and 2006, eight patients (5 males, 3 females; mean age 39.6 years; range 26 to 67 years) with hand sarcoma received treatment at two centers.
  • The lesions arose from soft tissue in five cases, and from bone in three cases.
  • RESULTS: Mortality occurred in two patients due to multiple metastases, who had synovial sarcoma in the carpal region and clear cell sarcoma in the wrist, respectively.
  • Apart from clear cell sarcoma, diagnoses of other wrist tumors were stage IIB epithelioid sarcoma and malignant fibrous histiocytoma.
  • [MeSH-major] Hand. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Severity of Illness Index. Treatment Outcome. Turkey / epidemiology

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  • (PMID = 18180558.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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60. Flannery T, Kano H, Niranjan A, Monaco EA 3rd, Flickinger JC, Kofler J, Lunsford LD, Kondziolka D: Gamma knife radiosurgery as a therapeutic strategy for intracranial sarcomatous metastases. Int J Radiat Oncol Biol Phys; 2010 Feb 1;76(2):513-9
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  • The primary pathology was metastatic leiomyosarcoma (4 patients), osteosarcoma (3 patients), soft-tissue sarcoma (5 patients), chondrosarcoma (2 patients), alveolar soft part sarcoma (2 patients), and rhabdomyosarcoma, Ewing's sarcoma, liposarcoma, neurofibrosarcoma, and synovial sarcoma (1 patient each).
  • [MeSH-major] Brain Neoplasms / surgery. Radiosurgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Survival Rate. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19467792.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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61. Clark MA, Johnson MB, Thway K, Fisher C, Thomas JM, Hayes AJ: Clear cell sarcoma (melanoma of soft parts): The Royal Marsden Hospital experience. Eur J Surg Oncol; 2008 Jul;34(7):800-4
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  • [Title] Clear cell sarcoma (melanoma of soft parts): The Royal Marsden Hospital experience.
  • INTRODUCTION: Clear cell sarcoma (CCS) is a rare tumour with a propensity for local recurrence and nodal metastasis.
  • METHODS: Patients with a histopathologic diagnosis of CCS were identified from prospective histopathology and sarcoma databases and supplemented with a retrospective analysis of the patients' hospital records.
  • [MeSH-major] Sarcoma, Clear Cell. Soft Tissue Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Combined Modality Therapy. Female. Great Britain / epidemiology. Humans. Lower Extremity. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prognosis. Retrospective Studies. Survival Rate. Upper Extremity

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  • (PMID = 18042498.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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62. Krasin MJ, Davidoff AM, Xiong X, Wu S, Hua CH, Navid F, Rodriguez-Galindo C, Rao BN, Hoth KA, Neel MD, Merchant TE, Kun LE, Spunt SL: Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma. Int J Radiat Oncol Biol Phys; 2010 Mar 1;76(3):874-8
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  • [Title] Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma.
  • PURPOSE: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS).
  • Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 19625137.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; None / None / / P30 CA021765-31; United States / NCI NIH HHS / CA / P30 CA021765-31
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS133810; NLM/ PMC2823850
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63. Evans SM, Fraker D, Hahn SM, Gleason K, Jenkins WT, Jenkins K, Hwang WT, Zhang P, Mick R, Koch CJ: EF5 binding and clinical outcome in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys; 2006 Mar 1;64(3):922-7
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  • [Title] EF5 binding and clinical outcome in human soft tissue sarcomas.
  • PURPOSE: To study the 2-nitroimidazole agent EF5 as a surrogate for measuring hypoxia in a series of patients with soft tissue sarcomas, and to determine whether hypoxia measured with this technique was associated with patient outcome.
  • METHODS AND MATERIALS: Patients with soft tissue sarcomas of the head and neck, extremity, trunk, or retroperitoneum for whom surgical excision was the initial treatment of choice, were given 21 mg/kg EF5 24-48 hours before surgery.
  • [MeSH-major] Cell Hypoxia / physiology. Etanidazole / analogs & derivatives. Hydrocarbons, Fluorinated / metabolism. Indicators and Reagents / metabolism. Neoplasm Recurrence, Local / metabolism. Sarcoma / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Survival Analysis. Treatment Outcome

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  • (PMID = 16458778.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00040; United States / NCI NIH HHS / CA / R01 CA 75285
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; 0 / Hydrocarbons, Fluorinated; 0 / Indicators and Reagents; 30DKA3Q1HL / Etanidazole
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64. Singh RP, Grimer RJ, Bhujel N, Carter SR, Tillman RM, Abudu A: Adult head and neck soft tissue sarcomas: treatment and outcome. Sarcoma; 2008;2008:654987
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  • [Title] Adult head and neck soft tissue sarcomas: treatment and outcome.
  • We have retrospectively analysed the experience of a musculoskeletal oncological unit in the management of adult head and neck soft tissue sarcomas from 1990 to 2005.
  • Adult head and neck soft tissue sarcomas have a high mortality rate with a high risk of local recurrence and metastatic disease.

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  • (PMID = 18382622.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2276692
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65. Canter RJ, Beal S, Borys D, Martinez SR, Bold RJ, Robbins AS: Interaction of histologic subtype and histologic grade in predicting survival for soft-tissue sarcomas. J Am Coll Surg; 2010 Feb;210(2):191-198.e2
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  • [Title] Interaction of histologic subtype and histologic grade in predicting survival for soft-tissue sarcomas.
  • BACKGROUND: Histologic grade is considered the paramount prognostic factor in predicting survival for soft-tissue sarcomas (STS).
  • Increasing data suggest that histologic type substantially impacts STS behavior.
  • STUDY DESIGN: The Surveillance, Epidemiology, and End Results program was used to identify 17,364 cases of STS diagnosed between 1988 and 2004.
  • Using death from STS as 1 of the outcomes variables, histologic types were grouped into 3 categories: favorable (survival >or= 20% above the mean), neutral (survival within 20% of the mean), and unfavorable (survival >or= 20% below the mean).
  • RESULTS: Among 73 histologic types, malignant fibrous histiocytoma (24.1%); leiomyosarcoma, not otherwise specified (14.8%); sarcoma, not otherwise specified (12.8%); and myxoid liposarcoma (5.9%) were the most prevalent.
  • Risk of death from STS increased with increasing grade: 8.0% for low, 25.9% for intermediate, and 38.3% for high.
  • Among low-grade tumors, risk of death from STS ranged from 4.3% for favorable types to 15.3% for unfavorable types.
  • Among intermediate-grade tumors, risk of death from STS ranged from 6.0% for favorable types to 45.4% for unfavorable types.
  • Among high-grade tumors, risk of death from STS ranged from 24.3% for favorable types to 58.9% for unfavorable types.
  • CONCLUSIONS: Within categories of STS grade, there are substantial differences in survival, depending on histologic type.
  • Histologic type is an important predictor of biologic behavior in STS.
  • [MeSH-major] Sarcoma / mortality. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Cohort Studies. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Retrospective Studies. Risk Factors. SEER Program. Survival Rate. United States

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  • (PMID = 20113939.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Hartmann JT, Oechsle K, Huober J, Jakob A, Azemar M, Horger M, Kanz L, Bokemeyer C: An open label, non-comparative phase II study of gemcitabine as salvage treatment for patients with pretreated adult type soft tissue sarcoma. Invest New Drugs; 2006 May;24(3):249-53
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  • [Title] An open label, non-comparative phase II study of gemcitabine as salvage treatment for patients with pretreated adult type soft tissue sarcoma.
  • BACKGROUND: The number of effective cytotoxic agents for the treatment of patients with metastatic adult type soft tissue sarcoma (STS) is limited, when patients have failed anthracyline-based chemotherapy.
  • CONCLUSIONS: Considering response and progression-free rate as the primary endpoints for phase II trials in pretreated STS, gemcitabine has moderate efficacy.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Male. Middle Aged


67. Abatzoglou S, Turcotte RE, Adoubali A, Isler MH, Roberge D: Local recurrence after initial multidisciplinary management of soft tissue sarcoma: is there a way out? Clin Orthop Relat Res; 2010 Nov;468(11):3012-8
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  • [Title] Local recurrence after initial multidisciplinary management of soft tissue sarcoma: is there a way out?
  • BACKGROUND: Multimodality treatment of primary soft tissue sarcoma by expert teams reportedly affords a low incidence of local recurrence.
  • QUESTIONS/PURPOSES: We (1) determined the incidence of local recurrence from soft tissue sarcoma;.
  • METHODS: From our prospective database, we identified 618 soft tissue sarcomas.
  • CONCLUSIONS: Patients with a local recurrence of a soft tissue sarcoma have a poor prognosis.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Orthopedic Procedures. Patient Care Team. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Amputation. Chi-Square Distribution. Databases as Topic. Female. Humans. Incidence. Kaplan-Meier Estimate. Limb Salvage. Male. Middle Aged. Neoplasm Staging. Quebec. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Risk Assessment. Risk Factors. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20700676.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2947683
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68. Saito N, Tsutsumida A, Furukawa H, Sekido M, Oyama A, Funayama E, Saito A, Yamamoto Y: Reconstructive considerations in the treatment of soft tissue sarcomas of the cheek. Acta Otorhinolaryngol Ital; 2010 Apr;30(2):103-6
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  • [Title] Reconstructive considerations in the treatment of soft tissue sarcomas of the cheek.
  • Soft tissue sarcomas of the head and neck region are rare, and very little has been described about the reconstructive methods used after sarcoma resection of cheek soft tissue sarcomas.
  • Reconstructive methods for cheek defects after sarcoma resection are presented and the possibilities, advantages, disadvantages, and expected results are described.
  • A series of 3 patients with cheek soft tissue sarcomas were examined.
  • [MeSH-major] Cheek. Facial Neoplasms / surgery. Reconstructive Surgical Procedures. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Middle Aged

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  • (PMID = 20559481.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2882148
  • [Keywords] NOTNLM ; Cervicofacial flap / Cheek / Soft tissue sarcoma / Surgical treatment
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69. Altan E, Bitik B, Kalpakci Y, Dogan E, Altundag K: Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee. J Altern Complement Med; 2009 Feb;15(2):113
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  • [Title] Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee.
  • [MeSH-major] Drug-Induced Liver Injury / etiology. Nerium / adverse effects. Plant Extracts / adverse effects. Sarcoma, Synovial. Soft Tissue Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Fatal Outcome. Female. Humans. Injections, Intramuscular. Knee Joint. Lung Neoplasms / secondary

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  • (PMID = 19216656.001).
  • [ISSN] 1557-7708
  • [Journal-full-title] Journal of alternative and complementary medicine (New York, N.Y.)
  • [ISO-abbreviation] J Altern Complement Med
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Plant Extracts
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70. Schreiber D, Bell RS, Wunder JS, O'Sullivan B, Turcotte R, Masri BA, Davis AM: Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma. Qual Life Res; 2006 Nov;15(9):1439-46
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  • [Title] Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma.
  • OBJECTIVE: To evaluate how functional disability impacts on health related quality of life (HRQOL) of patients with extremity soft tissue sarcoma (STS) at 1 year post-surgery.
  • DESIGN AND SETTING: Survey of extremity STS patients pre-surgery and one-year post-treatment.
  • PARTICIPANTS: 100 participants who were treated for extremity STS between 2001 and 2003 at four Canadian hospitals.
  • [MeSH-major] Activities of Daily Living. Quality of Life. Sarcoma / psychology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Canada. Databases, Factual. Disability Evaluation. Female. Humans. Linear Models. Male. Middle Aged. Multicenter Studies as Topic. Postoperative Period. Severity of Illness Index. Surveys and Questionnaires

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  • (PMID = 16732468.001).
  • [ISSN] 0962-9343
  • [Journal-full-title] Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
  • [ISO-abbreviation] Qual Life Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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71. Penel N, Grosjean J, Robin YM, Vanseymortier L, Clisant S, Adenis A: Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases. Sarcoma; 2008;2008:459386
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  • [Title] Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases.
  • Soft tissue sarcomas are rare tumours with infrequent identified aetiological factors.
  • Several genetic syndromes as well as previous radiation therapy and/or chronic lymphoedema have been suspected to predispose to some soft tissue sarcomas.
  • Between January 1997 and September 2005, we carried out a prospective descriptive study to estimate the frequency of some particular etiological factors among 658 patients with soft tissue sarcomas.
  • Finally, most of the adult soft tissue sarcomas are not related to any classical clinically identified genetic disease or previous radiation therapy and/or chronic lymphoedema risk factors.
  • Frequency of underlying genetic syndrome which may predispose to soft tissue sarcomas could be higher than previously reported.

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  • (PMID = 18497869.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2386887
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72. Ohmiya N, Taguchi A, Mabuchi N, Itoh A, Hirooka Y, Niwa Y, Goto H: MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis. J Clin Oncol; 2006 Sep 20;24(27):4434-40
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  • PURPOSE: Recently, a single-nucleotide polymorphism in the MDM2 promoter (SNP309) has been found to lower the age of onset of tumors and increase the occurrence of multiple primary tumors in Li-Fraumeni syndrome, and accelerate the development of sporadic adult soft tissue sarcoma.
  • Tumor tissue was immunostained with p53 and examined for mutations in exons 5 to 8 of p53 using polymerase chain reaction-based single strand conformational polymorphism analysis and direct sequencing.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Genes, p53. Genetic Markers / genetics. Genetic Predisposition to Disease. Genotype. Humans. Male. Middle Aged. Mutation. Odds Ratio. Polymerase Chain Reaction. Polymorphism, Single Nucleotide. Polymorphism, Single-Stranded Conformational. Predictive Value of Tests. Prognosis. Promoter Regions, Genetic. Risk Assessment. Risk Factors. Survival Analysis

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  • (PMID = 16983111.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Genetic Markers; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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73. Armstrong AV Jr, Aedo A, Phelps S: Synovial sarcoma: a case report. Clin Podiatr Med Surg; 2008 Apr;25(2):167-81, vi
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  • [Title] Synovial sarcoma: a case report.
  • Synovial sarcoma most commonly affects adults in the third to fifth decades of life, and is the most common sarcoma of the foot.
  • This article discusses the case of a young patient who presented to the foot and ankle clinic with soft tissue swelling in the right foot, and the imaging protocol for such a patient.
  • A literature review of synovial sarcoma is also presented.
  • [MeSH-major] Foot Diseases / diagnosis. Sarcoma, Synovial / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Amputation. Artificial Limbs. Chemotherapy, Adjuvant. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18346589.001).
  • [ISSN] 0891-8422
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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74. Fiore M, Casali PG, Miceli R, Mariani L, Bertulli R, Lozza L, Collini P, Olmi P, Mussi C, Gronchi A: Prognostic effect of re-excision in adult soft tissue sarcoma of the extremity. Ann Surg Oncol; 2006 Jan;13(1):110-7
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  • [Title] Prognostic effect of re-excision in adult soft tissue sarcoma of the extremity.
  • BACKGROUND: We explored the outcome of patients with primary adult soft tissue sarcoma (STS) of the extremities undergoing re-excision after previous unplanned surgery.
  • METHODS: A total of 597 consecutive adult patients with primary extremity STS were treated with conservative surgery at our institution over a 20-year time span.
  • The assessed end points were sarcoma-specific mortality, local recurrence, and distant metastasis.
  • CONCLUSIONS: At a referral center with a liberal policy of re-excisions in adult primary STS of the extremities, the outcome of patients who underwent re-excision was similar to that of patients who had primary resections.
  • [MeSH-major] Neoplasm, Residual / surgery. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Combined Modality Therapy. Extremities. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Radiotherapy, Adjuvant. Regression Analysis. Reoperation. Treatment Outcome

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  • (PMID = 16372156.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Nicolas M, Moran CA, Suster S: Pulmonary metastasis from liposarcoma: a clinicopathologic and immunohistochemical study of 24 cases. Am J Clin Pathol; 2005 Feb;123(2):265-75
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  • Most PLs (6/8) were nonlipogenic and resembled an undifferentiated pleomorphic sarcoma.
  • [MeSH-major] Liposarcoma / secondary. Lung Neoplasms / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 15842053.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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76. Gallia GL, Sciubba DM, Hann CL, Raman SP, Westra WH, Tufaro AP, Olivi A: Synovial sarcoma of the frontal sinus. Case report. J Neurosurg; 2005 Dec;103(6):1077-80
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  • [Title] Synovial sarcoma of the frontal sinus. Case report.
  • Synovial sarcoma is a soft-tissue lesion occurring predominantly in the extremities of young adults.
  • Although the head and neck region is the second most common site of involvement, synovial sarcoma has rarely been reported in the paranasal sinus.
  • The authors present a case of synovial sarcoma arising from the frontal sinus and review the literature of synovial sarcomas arising from the paranasal sinuses.
  • [MeSH-major] Frontal Sinus. Paranasal Sinus Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 16381195.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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77. Nascimento AF, Bertoni F, Fletcher CD: Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. Am J Surg Pathol; 2007 Jan;31(1):99-105
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  • Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas of elderly patients and has a predilection for the limbs.
  • In 10 cases, the tumor was located in subcutaneous tissue and in 6 cases it was subfascial.
  • [MeSH-major] Epithelioid Cells / pathology. Fibrosarcoma / secondary. Sarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Extremities. Fatal Outcome. Female. Humans. Immunoenzyme Techniques. Liposarcoma / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Myoepithelioma / diagnosis. Rhabdomyosarcoma / diagnosis

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  • (PMID = 17197925.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Wakulińska A, Dembowska-Bagińska B, Cienciała M, Bothur-Nowacka J, Kościesza A, Pakuła-Kościesza I, Perek D: [Results of the treatment of paediatric non-rhabdomyosarcoma. One centre experience]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 1):819-29
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  • Non-rhabdomyosarcoma soft tissue sarcomas (NR STS) are a rare group of neoplasms of mesenchymal origin.
  • THE AIM of our study was to analyze methods and treatment results of patients with NR STS treated in our centre.
  • MATERIALS AND METHODS: Between 1996 and 2004, 64 patients with NR-STS, aged 2.5-21.5 yrs, were treated in our institution.
  • High number of patients with stage IV disease at diagnosis, occurrence of distant relapses and good response to chemotherapy indicate the necessity for the use of chemotherapy in patients with NR STS.
  • [MeSH-major] Sarcoma / epidemiology. Sarcoma / therapy. Soft Tissue Neoplasms / epidemiology. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Male. Poland / epidemiology. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 17317913.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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79. Van Damme JP, Schmitz S, Machiels JP, Galant C, Grégoire V, Lengelé B, Hamoir M: Prognostic factors and assessment of staging systems for head and neck soft tissue sarcomas in adults. Eur J Surg Oncol; 2010 Jul;36(7):684-90
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  • [Title] Prognostic factors and assessment of staging systems for head and neck soft tissue sarcomas in adults.
  • OBJECTIVES: The primary objectives of this study were to analyse the outcome of patients diagnosed with head and neck soft tissue sarcomas (HNSTS) and to identify relevant prognostic factors.
  • METHODS: From 07/1988 to 01/2008, the charts of 42 adult patients were retrospectively reviewed.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Risk Assessment. Risk Factors

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  • (PMID = 20542404.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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80. Pfannschmidt J, Klode J, Muley T, Dienemann H, Hoffmann H: Pulmonary metastasectomy in patients with soft tissue sarcomas: experiences in 50 patients. Thorac Cardiovasc Surg; 2006 Oct;54(7):489-92
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  • [Title] Pulmonary metastasectomy in patients with soft tissue sarcomas: experiences in 50 patients.
  • BACKGROUND: Pulmonary resection of metastatic soft tissue sarcomas is an accepted method of treatment.
  • METHODS: Between 1996 and 2001, 50 patients (27 men, 23 women) with pulmonary metastases from a soft tissue sarcoma underwent surgical resection.
  • CONCLUSION: We conclude that pulmonary resection of metastatic soft tissue sarcomas is a safe and effective treatment, which offers an improved survival benefit.
  • [MeSH-major] Lung Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 17089318.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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81. Kayton ML, Delgado R, Busam K, Cody HS 3rd, Athanasian EA, Coit D, La Quaglia MP: Experience with 31 sentinel lymph node biopsies for sarcomas and carcinomas in pediatric patients. Cancer; 2008 May 1;112(9):2052-9
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  • No other patients had positive sentinel lymph nodes, and among those with nonrhabdomyosarcoma soft-tissue sarcomas there were no lymph node basin recurrences despite a lack of lymph node basin irradiation or formal lymph node dissection.
  • CONCLUSIONS: Sentinel lymph node biopsy for pediatric soft-tissue tumors can be performed safely, and the results can alter treatment decisions both for children with rhabdomyosarcoma and adolescents with breast cancer.
  • In patients with nonrhabdomyosarcoma soft-tissue sarcoma, we observed no positive sentinel lymph nodes and no lymph node basin recurrences; these data should prompt the prospective study of sentinel lymph node biopsy as a modality that might help guide the administration or withholding of regional therapy among pediatric patients with nonrhabdomyosarcoma soft-tissue sarcoma.
  • [MeSH-major] Carcinoma / pathology. Sarcoma / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adolescent. Adult. Breast Neoplasms / pathology. Child. Child, Preschool. Female. Humans. Lymphography. Male. Middle Aged. Retrospective Studies. Rhabdomyosarcoma / pathology. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Clear Cell / pathology

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  • (PMID = 18338809.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Yang J, Yang D, Cogdell D, Du X, Li H, Pang Y, Sun Y, Hu L, Sun B, Trent J, Chen K, Zhang W: APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival. Technol Cancer Res Treat; 2010 Apr;9(2):161-9
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  • We sought to gain insight into the role of APEX1 in human osteosarcoma by evaluation of gene copy number alterations and its protein expression in osteosarcoma patients treated at the Sarcoma Center of Tianjin Cancer Hospital (Tianjin, China).
  • To evaluate the gene copy number alterations of APEX1, we acquired 10 fresh tissue samples from 9 patients and performed whole-genome array-based comparative genomic hybridization (aCGH).
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Disease-Free Survival. Female. Gene Amplification. Gene Dosage. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Male. Neoplasm Staging. Prognosis. Young Adult


83. Ruka W, Rutkowski P, Morysiński T, Nowecki Z, Zdzienicki M, Makula D, Ptaszyński K, Bylina E, Grzesiakowska U: The megavoltage radiation therapy in treatment of patients with advanced or difficult giant cell tumors of bone. Int J Radiat Oncol Biol Phys; 2010 Oct 1;78(2):494-8
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  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Radiotherapy Dosage. Treatment Outcome. Tumor Burden. Young Adult

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20004531.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Khademi B, Mohammadianpanah M, Ashraf MJ, Yeganeh F: Synovial sarcoma of the parapharyngeal space. Auris Nasus Larynx; 2007 Mar;34(1):125-9
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  • [Title] Synovial sarcoma of the parapharyngeal space.
  • Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space.
  • Pathologic report disclosed the diagnosis of synovial sarcoma.
  • [MeSH-major] Pharyngeal Neoplasms / radiotherapy. Pharyngeal Neoplasms / surgery. Sarcoma, Synovial / radiotherapy. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Radiotherapy Dosage

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  • (PMID = 17056221.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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85. Balkan İ, Ozaras R, Mert A: Infected Kaposi's sarcoma. Intern Med; 2010;49(23):2649
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  • [Title] Infected Kaposi's sarcoma.
  • [MeSH-major] Enterococcus faecalis. Gram-Positive Bacterial Infections / diagnosis. Sarcoma, Kaposi / diagnosis. Soft Tissue Infections / diagnosis
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 21139313.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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86. Comin CE, Novelli L, Tornaboni D, Messerini L: Clear cell sarcoma of the ileum: report of a case and review of literature. Virchows Arch; 2007 Oct;451(4):839-45
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  • [Title] Clear cell sarcoma of the ileum: report of a case and review of literature.
  • Clear cell sarcoma (CCS) is a high grade soft tissue sarcoma with a distinct molecular profile and with morphological features resembling those of melanoma.
  • CCS has been rarely described in other locations other than the soft tissues, including the gastrointestinal tract.
  • Fluorescence in situ hybridization analysis demonstrated the presence of a t(12;22)(q13;q12) translocation, the diagnostic hallmark of CCS of soft parts.
  • The present case, together with a detailed review of the literature on this topic, demonstrates that the gastrointestinal tract is a possible site of CCS of soft tissues and that making a reliable diagnosis of this tumor requires cytogenetic or molecular diagnostic investigations.
  • [MeSH-major] Ileal Neoplasms / diagnosis. Sarcoma, Clear Cell / diagnosis
  • [MeSH-minor] Adult. Female. Humans. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 17636326.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 30
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87. Kumar R, Rekhi B, Shirazi N, Pais A, Amare P, Gawde D, Jambhekar N: Spectrum of cytomorphological features, including literature review, of an extraskeletal myxoid chondrosarcoma with t(9;22)(q22;q12) (TEC/EWS) results in one case. Diagn Cytopathol; 2008 Dec;36(12):868-75
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  • Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon soft tissue sarcoma with evolving literature on its cytomorphological features and limited documentation of its molecular analysis.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18925568.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA-Binding Protein EWS
  • [Number-of-references] 29
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88. Kasper B, Ho AD, Egerer G: Dose-intensive chemotherapy with stem cell support as a treatment strategy for bone and soft-tissue sarcomas. Curr Stem Cell Res Ther; 2006 Jan;1(1):29-35
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  • [Title] Dose-intensive chemotherapy with stem cell support as a treatment strategy for bone and soft-tissue sarcomas.
  • Whether high-dose chemotherapy with stem cell support improves the long-term outcome for patients with bone and soft-tissue sarcoma is debatable and controversial.
  • Prognosis of patients with unresectable or advanced metastatic sarcoma remains poor with a disease-free survival at 5 years less than 10%; treatment is generally considered to be palliative.
  • However, all studies were not randomized, comprised small patient numbers and included heterogeneous histological subtypes of soft-tissue sarcomas.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bone Neoplasms / therapy. Sarcoma / therapy. Stem Cell Transplantation
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Humans. Middle Aged. Neoplasm Metastasis. Sarcoma, Ewing / therapy. Survival Analysis

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  • (PMID = 18220851.001).
  • [ISSN] 1574-888X
  • [Journal-full-title] Current stem cell research & therapy
  • [ISO-abbreviation] Curr Stem Cell Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United Arab Emirates
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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89. Hussein R, Smith MA: Soft tissue sarcomas: are current referral guidelines sufficient? Ann R Coll Surg Engl; 2005 May;87(3):171-3
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  • [Title] Soft tissue sarcomas: are current referral guidelines sufficient?
  • INTRODUCTION: To investigate the adequacy of current early referral guidelines for patients with extremity soft tissue sarcomas.
  • PATIENTS & METHODS: 365 patients with confirmed soft tissue sarcomas were evaluated.
  • CONCLUSION: Although the majority of soft tissue sarcomas in our patients had one or more of the clinical guideline features, there was still an unacceptable delay in referring these patients to a specialist unit.
  • This combined with increased awareness of these guidelines and a well-advertised, open-access clinic linked to a specialist unit should allow for a more rapid evaluation of soft tissue tumours.
  • [MeSH-major] Practice Guidelines as Topic / standards. Referral and Consultation / standards. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. London. Male. Middle Aged. Pain / etiology. Prospective Studies. Time Factors

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  • (PMID = 15901376.001).
  • [ISSN] 0035-8843
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1963892
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90. Mulrooney DA, Yeazel MW, Kawashima T, Mertens AC, Mitby P, Stovall M, Donaldson SS, Green DM, Sklar CA, Robison LL, Leisenring WM: Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ; 2009 Dec 08;339:b4606
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  • [Title] Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort.
  • OBJECTIVES: To assess the incidence of and risks for congestive heart failure, myocardial infarction, pericardial disease, and valvular abnormalities among adult survivors of childhood and adolescent cancers.
  • PARTICIPANTS: 14,358 five year survivors of cancer diagnosed under the age of 21 with leukaemia, brain cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, kidney cancer, neuroblastoma, soft tissue sarcoma, or bone cancer between 1970 and 1986.
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Case-Control Studies. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Prognosis. Retrospective Studies. United States. Young Adult

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  • [CommentIn] BMJ. 2009;339:b4691 [19996460.001]
  • (PMID = 19996459.001).
  • [ISSN] 1756-1833
  • [Journal-full-title] BMJ (Clinical research ed.)
  • [ISO-abbreviation] BMJ
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U24 CA 55727; United States / NCI NIH HHS / CA / U24 CA055727; United States / NCRR NIH HHS / RR / 1K12RR023247; United States / NCI NIH HHS / CA / U24 CA055727-17; United States / NCRR NIH HHS / RR / K12 RR023247-05; United States / NCRR NIH HHS / RR / K12 RR023247
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3266843
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91. Thanakit V, Nelson SD, Udomsawaengsup S: Round cell liposarcoma of scrotum with indolent course in young adult. J Med Assoc Thai; 2005 Sep;88(9):1302-7
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  • [Title] Round cell liposarcoma of scrotum with indolent course in young adult.
  • Round cell liposarcoma is highly metastatic and is classified as high grade and poorly differentiated myxoid sarcoma.
  • Most masses within the scrotal sac arise from the testis proper, and less likely from the extratesticular tissue.
  • Myxoid/round cell liposarcoma and round cell liposarcoma are rarely encounter in extratesticular soft tissue.
  • We reported a rare case of round cell liposarcoma (high grade myxoid liposarcoma) of extratesticular tissue.
  • To our knowledge, this is the first case of a large size (> 5cm) round cell liposarcoma arising from soft tissue within the scrotal sac of young adult with indolent course.
  • Simple excision or enucleation are inadequate therapies and wide excision of the hemiscrotum including inguinal soft tissue and nodes is recommended.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Prognosis. Scrotum / pathology. Testicular Hydrocele / pathology

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  • (PMID = 16536120.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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92. Zamani F, Jabbari M, Alimohamadi SM, Shakeri R, Rostami Z, Abedi B, Hormazdi M, Malekzadeh R: Primary alveolar soft part sarcoma of chest wall: a case report and review of the literature. MedGenMed; 2006;8(3):2
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  • [Title] Primary alveolar soft part sarcoma of chest wall: a case report and review of the literature.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Soft Tissue Neoplasms / diagnosis. Thoracic Wall
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Fatal Outcome. Female. Humans. Lung Neoplasms / secondary. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 17406145.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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93. Georgalas C, Kapoor L, Chau H, Bhattacharyya A: Inflammatory focal myositis of the sternomastoid muscle: is there an absolute indication for biopsy? A case report and review of the literature. Eur Arch Otorhinolaryngol; 2006 Feb;263(2):149-51
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  • Focal myositis is a localised inflammatory process affecting skeletal muscles belonging to the pathological group of inflammatory pseudo tumours of soft tissue that includes myositis ossificans, proliferative myositis and nodular pseudosarcomatous fasciitis.
  • Very rarely, it may affect one of the neck muscles and present as a neck lump, in which case both the clinical and pathological picture can mimic a sarcoma.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 16362267.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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94. Maurel J, López-Pousa A, de Las Peñas R, Fra J, Martín J, Cruz J, Casado A, Poveda A, Martínez-Trufero J, Balañá C, Gómez MA, Cubedo R, Gallego O, Rubio-Viqueira B, Rubió J, Andrés R, Sevilla I, de la Cruz JJ, Del Muro XG, Buesa JM: Efficacy of sequential high-dose doxorubicin and ifosfamide compared with standard-dose doxorubicin in patients with advanced soft tissue sarcoma: an open-label randomized phase II study of the Spanish group for research on sarcomas. J Clin Oncol; 2009 Apr 10;27(11):1893-8
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  • [Title] Efficacy of sequential high-dose doxorubicin and ifosfamide compared with standard-dose doxorubicin in patients with advanced soft tissue sarcoma: an open-label randomized phase II study of the Spanish group for research on sarcomas.
  • PURPOSE: To assess the progression-free survival (PFS) and antitumor response to standard-dose doxorubicin compared with sequential dose-dense doxorubicin and ifosfamide in first-line treatment of advanced soft tissue sarcoma.
  • PATIENTS AND METHODS: Patients with measurable advanced soft tissue sarcoma, Eastern Cooperative Oncology Group (ECOG) performance status (PS) < 2, between the ages 18 and 65 years, and with adequate bone marrow, liver, and renal function were entered in the study.
  • CONCLUSION: Single-agent doxorubicin remains the standard treatment in fit patients with advanced soft tissue sarcoma.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Doxorubicin / administration & dosage. Ifosfamide / administration & dosage. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Disease Progression. Dose-Response Relationship, Drug. Female. Humans. Male. Middle Aged. Remission Induction. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 19273704.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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95. Hantschke M, Mentzel T, Rütten A, Palmedo G, Calonje E, Lazar AJ, Kutzner H: Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma. Am J Surg Pathol; 2010 Feb;34(2):216-22
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  • [Title] Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma.
  • Clear cell sarcoma (CCS) of tendons and aponeuroses/malignant melanoma (MM) of soft parts is a rare tumor and in the majority of cases presents a characteristic reciprocal translocation t(12;22)(q13;q12) that results in fusion of the EWS and ATF1 genes.
  • CCS is classically regarded as a deep soft tissue tumor associated with tendons or aponeuroses.


96. Tsakonas GP, Kallistratos MS, Balamoti EK, Gassiamis A, Zizi-Sermpetzoglou A, Mylonakis N, Karabelis A, Kosmas C: Rare and aggressive metastatic, axial multifocal local epithelioid sarcoma associated with paraneoplastic granulocytosis and hypoglycaemia. Lancet Oncol; 2007 Jan;8(1):82-4
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  • [Title] Rare and aggressive metastatic, axial multifocal local epithelioid sarcoma associated with paraneoplastic granulocytosis and hypoglycaemia.
  • [MeSH-major] Granulocytes / pathology. Hypoglycemia. Paraneoplastic Syndromes. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / therapy


97. Riggi N, Stamenkovic I: The Biology of Ewing sarcoma. Cancer Lett; 2007 Aug 28;254(1):1-10
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  • [Title] The Biology of Ewing sarcoma.
  • They constitute some of the most aggressive adult and childhood cancers in that they have a high metastatic proclivity and are typically refractory to conventional chemo- and radiation therapy.
  • Ewing's sarcoma is a member of Ewing's family tumors (ESFT) and the second most common solid bone and soft tissue malignancy of children and young adults.
  • This review will highlight some of the most recent discoveries in the field of Ewing sarcoma biology and origins.
  • [MeSH-major] Sarcoma, Ewing / genetics. Sarcoma, Ewing / pathology

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  • (PMID = 17250957.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
  • [Number-of-references] 74
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98. Al Yami A, Griffin AM, Ferguson PC, Catton CN, Chung PW, Bell RS, Wunder JS, O'Sullivan B: Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary? Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):1191-7
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  • [Title] Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary?
  • PURPOSE: For patients with an extremity soft tissue sarcoma (STS) treated with preoperative radiotherapy and surgically excised with positive margins, we retrospectively reviewed whether a postoperative radiation boost reduced the risk of local recurrence (LR).
  • METHODS AND MATERIALS: A total of 216 patients with positive margins after resection of an extremity STS treated between 1986 and 2003 were identified from our institution's prospectively collected database.
  • [MeSH-major] Sarcoma / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amputation. Female. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / prevention & control. Histiocytoma, Benign Fibrous / radiotherapy. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / prevention & control. Leiomyosarcoma / radiotherapy. Leiomyosarcoma / surgery. Limb Salvage. Liposarcoma / pathology. Liposarcoma / prevention & control. Liposarcoma / radiotherapy. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm, Residual. Postoperative Care. Radiotherapy Dosage. Retreatment. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):959; author reply 959-60 [21621120.001]
  • (PMID = 20056340.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Saito R, Kumabe T, Watanabe M, Jokura H, Shibuya M, Nakazato Y, Tominaga T: Low-grade fibromyxoid sarcoma of intracranial origin. J Neurosurg; 2008 Apr;108(4):798-802
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  • [Title] Low-grade fibromyxoid sarcoma of intracranial origin.
  • The authors report on a 21-year-old man who presented with a low-grade fibromyxoid sarcoma primarily located in the right parietal lobe with diffuse infiltration.
  • The low-grade fibromyxoid sarcoma is a rare sarcoma of the deep soft tissue that is characterized as an indolent but metastasizing soft-tissue neoplasm with a deceptively benign histological appearance.
  • A high rate of local recurrence and eventual metastasis has been demonstrated for this tumor in deep soft tissue.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Sarcoma / diagnosis. Sarcoma / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Radiosurgery. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 18377261.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Baratti D, Pennacchioli E, Casali PG, Bertulli R, Lozza L, Olmi P, Collini P, Radaelli S, Fiore M, Gronchi A: Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol; 2007 Dec;14(12):3542-51
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  • [Title] Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution.
  • BACKGROUND: Epithelioid sarcoma (ES) is a rare subtype of soft-tissue sarcoma of unknown histogenesis.
  • [MeSH-major] Epithelioid Cells / pathology. Sarcoma / mortality. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17909905.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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