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26. Carpentieri DF, Qualman SJ, Bowen J, Krausz T, Marchevsky A, Dickman PS, Cancer Committee, College of American Pathologists: Protocol for the examination of specimens from pediatric and adult patients with osseous and extraosseous ewing sarcoma family of tumors, including peripheral primitive neuroectodermal tumor and ewing sarcoma. Arch Pathol Lab Med; 2005 Jul;129(7):866-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Protocol for the examination of specimens from pediatric and adult patients with osseous and extraosseous ewing sarcoma family of tumors, including peripheral primitive neuroectodermal tumor and ewing sarcoma.
  • [MeSH-major] Bone Neoplasms / classification. Clinical Protocols. Neuroectodermal Tumors, Primitive, Peripheral / classification. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Sarcoma, Ewing / classification. Sarcoma, Ewing / pathology. Soft Tissue Neoplasms / classification
  • [MeSH-minor] Adult. Child. Humans

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  • (PMID = 15974809.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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27. Doglietto GB, Tortorelli AP, Papa V, Rosa F, Bossola M, Prete FP, Covino M, Pacelli F: Giant retroperitoneal sarcomas: a single institution experience. World J Surg; 2007 May;31(5):1047-54
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  • BACKGROUND: Retroperitoneal sarcomas (RS) are a rare group of malignant soft-tissue tumors; due to the flexibility of the retroperitoneum, they generally grow to a large size before becoming symptomatic, often involving surrounding structures.
  • [MeSH-major] Retroperitoneal Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Prognosis. Proportional Hazards Models. Survival Analysis. Treatment Outcome

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  • (PMID = 17345124.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
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28. Rutkowski P, Nowecki ZI, Zurawski Z, Dziewirski W, Nasierowska-Guttmejer A, Switaj T, Ruka W: In transit/local recurrences in melanoma patients after sentinel node biopsy and therapeutic lymph node dissection. Eur J Cancer; 2006 Jan;42(2):159-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16324835.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Zalcberg JR, Verweij J, Casali PG, Le Cesne A, Reichardt P, Blay JY, Schlemmer M, Van Glabbeke M, Brown M, Judson IR, EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group, Australasian Gastrointestinal Trials Group: Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur J Cancer; 2005 Aug;41(12):1751-7
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  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Benzamides. Cross-Over Studies. Disease Progression. Dose-Response Relationship, Drug. Feasibility Studies. Female. Humans. Imatinib Mesylate. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16098458.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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30. Hwang S, Lefkowitz R, Landa J, Akin O, Schwartz LH, Cassie C, Healey JH, Alektiar KM, Panicek DM: Local changes in bone marrow at MRI after treatment of extremity soft tissue sarcoma. Skeletal Radiol; 2009 Jan;38(1):11-9
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  • [Title] Local changes in bone marrow at MRI after treatment of extremity soft tissue sarcoma.
  • OBJECTIVE: To determine the prevalence and appearance of magnetic resonance imaging (MRI) signal changes that occur in local bone marrow after radiation therapy (RT) and/or chemotherapy for extremity soft tissue sarcoma (STS).
  • MATERIALS AND METHODS: Seventy patients with primary STS at the level of a long bone who also had undergone pretreatment MRI and at least one post-treatment MRI of the tumor bed were identified.
  • CONCLUSION: Changes in MRI appearance of long bone marrow frequently are evident after combined RT and chemotherapy for STS and most commonly increase or fluctuate in size over time.
  • [MeSH-major] Bone Marrow / pathology. Magnetic Resonance Imaging / methods. Sarcoma / drug therapy. Sarcoma / radiotherapy. Soft Tissue Neoplasms / drug therapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Contrast Media. Disease Progression. Extremities. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18704399.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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46. Ward E, Doody O, d'Adhemar C, Swan N, Torreggiani WC: Answer to case of the month #149 alveolar soft-part sarcoma. Can Assoc Radiol J; 2009 Jun;60(3):143-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Answer to case of the month #149 alveolar soft-part sarcoma.
  • [MeSH-major] Lung Neoplasms / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Contrast Media. Cough / etiology. Diagnosis, Differential. Fatigue / etiology. Gadolinium. Humans. Image Enhancement / methods. Knee / pathology. Lung / radiography. Magnetic Resonance Imaging. Male. Rare Diseases

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  • (PMID = 19591765.001).
  • [ISSN] 0846-5371
  • [Journal-full-title] Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
  • [ISO-abbreviation] Can Assoc Radiol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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47. Rutkowski P, Nowecki ZI, Michej W, Debiec-Rychter M, Woźniak A, Limon J, Siedlecki J, Grzesiakowska U, Kakol M, Osuch C, Polkowski M, Głuszek S, Zurawski Z, Ruka W: Risk criteria and prognostic factors for predicting recurrences after resection of primary gastrointestinal stromal tumor. Ann Surg Oncol; 2007 Jul;14(7):2018-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Prognosis. Registries. Risk Factors

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  • (PMID = 17473953.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Bode B, Frigerio S, Behnke S, Senn B, Odermatt B, Zimmermann DR, Moch H: Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma. Mod Pathol; 2006 Apr;19(4):541-7
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  • [Title] Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma.
  • To clarify the role of EGFR in synovial sarcoma and to explore the potential for a targeted therapy approach, we have examined 13 of these soft tissue tumors.
  • [MeSH-major] Mutation. Receptor, Epidermal Growth Factor / genetics. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Binding Sites / genetics. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Molecular Sequence Data. Mutation, Missense. Point Mutation. Protein-Tyrosine Kinases / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16514409.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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49. Fletcher CD: The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology; 2006 Jan;48(1):3-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The evolving classification of soft tissue tumours: an update based on the new WHO classification.
  • The new WHO classification of soft tissue tumours was introduced in late 2002 and, because it represents a broad consensus view, it has gained widespread acceptance.
  • (ii) the general acceptance that most pleomorphic sarcomas can be meaningfully subclassified and that so-called malignant fibrous histiocytoma is not a definable entity, but instead represents a wastebasket of undifferentiated pleomorphic sarcomas, accounting for no more than 5% of adult soft tissue sarcomas;.
  • (iii) the acknowledgement that most lesions formerly known as haemangiopericytoma show no evidence of pericytic differentiation and, instead, are fibroblastic in nature and form a morphological continuum with solitary fibrous tumour; and (iv) the increasing appreciation that not only do we not know from which cell type(s) most soft tissue tumours originate (histogenesis) but, for many, we do not recognize their line of differentiation or lineage--hence an increasing number of tumours are placed in the "uncertain differentiation" category.
  • [MeSH-major] Sarcoma / classification. Soft Tissue Neoplasms / classification. World Health Organization


50. Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF: Why do patients with low-grade soft tissue sarcoma die? Ann Surg Oncol; 2008 Dec;15(12):3550-60
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  • [Title] Why do patients with low-grade soft tissue sarcoma die?
  • INTRODUCTION: The patterns of failure and mechanisms of sarcoma-specific death are poorly characterized among the minority of patients with low-grade soft tissue sarcoma (STS) who succumb to disease.
  • METHODS: Between 1982 and 2006, 2,041 patients aged >or=16 years with low-grade STS of all sites were treated with curative intent and prospectively followed at a single institution.
  • In 17 patients (9%), the mechanism of sarcoma-related death could not be verified.
  • CONCLUSION: Among patients with low-grade STS, DOD occurs in approximately 9% of patients.

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  • (PMID = 18830667.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA047179-09; United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA 047179; United States / NCI NIH HHS / CA / P01 CA047179-09
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS75337; NLM/ PMC2605207
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51. Potocki K, Prutki M, Kralik M, Hrabak M, Padovan RS: Ewing's sarcoma of the third metatarsal: a case report and review of the literature. Tumori; 2007 Mar-Apr;93(2):210-2
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  • [Title] Ewing's sarcoma of the third metatarsal: a case report and review of the literature.
  • We report a rare case of Ewing's sarcoma involving the third metatarsal bone and spreading into adjacent bone in a 23-year-old man, with special emphasis on imaging characteristics.
  • Computed tomography and magnetic resonance imaging delineated the osseous and soft tissue extent of the tumor.
  • A large soft-tissue mass around the involved bone was highly indicative of Ewing's sarcoma.
  • An early diagnosis of Ewing's sarcoma, even when it occurs in unusual locations, is necessary for adequate treatment and is of particular importance in terms of prognosis.
  • The optimal imaging modality for the diagnosis of Ewing's sarcoma is magnetic resonance imaging since it allows accurate analysis of the soft-tissue component and visualization of possible local invasion of adjacent structures.
  • [MeSH-major] Diagnostic Imaging / methods. Metatarsal Bones / pathology. Sarcoma, Ewing / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Radiography. Tomography, X-Ray Computed

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  • (PMID = 17557573.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Pollock RE: The seminal role of Cancer in our understanding of sarcoma. Cancer; 2008 Oct 1;113(7 Suppl):1969-79
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  • [Title] The seminal role of Cancer in our understanding of sarcoma.
  • The journal Cancer has played a critical role in advancing our understanding of sarcoma, a remarkable cluster of malignancies that arise from tissues of mesenchymal origin throughout the human body and indeed across the entire vertebrate animal spectrum.
  • Approximately equally divided between soft tissue and bone origin, there are greater than 100 recognized histologic subtypes that collectively account for approximately 2% of adult solid tumors.
  • [MeSH-major] Medical Oncology. Periodicals as Topic. Sarcoma / therapy

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  • (PMID = 18798535.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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53. Schwab JH, Boland PJ, Antonescu C, Bilsky MH, Healey JH: Spinal metastases from myxoid liposarcoma warrant screening with magnetic resonance imaging. Cancer; 2007 Oct 15;110(8):1815-22
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  • BACKGROUND: Myxoid liposarcoma (MLS) has an unusual tendency for extrapulmonary metastasis, particularly to the spine and soft tissues.
  • METHODS: Data from patients with had spinal metastases were obtained from the authors' institutional soft tissue sarcoma database.
  • [MeSH-major] Liposarcoma, Myxoid / secondary. Magnetic Resonance Imaging. Soft Tissue Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Positron-Emission Tomography. Predictive Value of Tests. Radiopharmaceuticals. Sensitivity and Specificity. Survival Rate


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4. Davidson AW, Hong A, McCarthy SW, Stalley PD: En-bloc resection, extracorporeal irradiation, and re-implantation in limb salvage for bony malignancies. J Bone Joint Surg Br; 2005 Jun;87(6):851-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Bone Neoplasms / radiotherapy. Limb Salvage / methods. Replantation / methods. Sarcoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Female. Femur / radiography. Femur / surgery. Follow-Up Studies. Humans. Humerus / radiography. Humerus / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Pelvic Bones / radiography. Pelvic Bones / surgery. Tibia / radiography. Tibia / surgery. Treatment Outcome

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  • (PMID = 15911672.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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55. Moncrieff MD, Kroon HM, Kam PC, Stalley PD, Scolyer RA, Thompson JF: Isolated limb infusion for advanced soft tissue sarcoma of the extremity. Ann Surg Oncol; 2008 Oct;15(10):2749-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated limb infusion for advanced soft tissue sarcoma of the extremity.
  • We report our experience with ILI for the treatment of soft tissue sarcoma (STS).
  • METHODS: From our prospective database, 21 patients with STS of the limb treated with ILI between 1994 and 2007 were identified.
  • ILI is a minimally invasive alternative to isolated limb perfusion for patients with advanced STS of the extremity.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Cancer, Regional Perfusion. Extremities / pathology. Neoplasm Recurrence, Local / drug therapy. Sarcoma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Dactinomycin / administration & dosage. Female. Humans. Male. Melphalan / administration & dosage. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Prognosis. Prospective Studies. Survival Rate

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  • (PMID = 18648882.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; Q41OR9510P / Melphalan
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56. Hawkins DS, Bradfield S, Whitlock JA, Krailo M, Franklin J, Blaney SM, Adamson PC, Reaman G: Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer; 2006 Nov;47(6):790-4
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  • PROCEDURE: Patients with Ewing sarcoma family of tumors (ESFT), osteosarcoma (OS), soft tissue sarcomas (STS), medulloblastoma (MB)/primitive neuroectodermal tumor (PNET), astrocytoma, or neuroblastoma (NB) recurrent or refractory to conventional therapy, measurable disease, and adequate organ function were treated with topotecan 0.3 mg/m2/day by continuous intravenous infusion for 21 consecutive days, followed by 7 days without therapy prior to response assessment.
  • Objective responses were seen in 2/20 patients with ESFT (both partial responses, 4 and 19 courses), 0/10 OS patients, and 0/12 STS patients.
  • [MeSH-major] Astrocytoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Neuroblastoma / drug therapy. Neuroectodermal Tumors, Primitive / drug therapy. Sarcoma / drug therapy. Topotecan / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Dose-Response Relationship, Drug. Fatigue / chemically induced. Female. Humans. Infusions, Intravenous. Male. Maximum Tolerated Dose. Neutropenia / chemically induced. Recurrence. Survival Rate. Thrombocytopenia / chemically induced. Time Factors. Treatment Outcome


57. Jambhekar NA, Bagwan IN, Ghule P, Shet TM, Chinoy RF, Agarwal S, Joshi R, Amare Kadam PS: Comparative analysis of routine histology, immunohistochemistry, reverse transcriptase polymerase chain reaction, and fluorescence in situ hybridization in diagnosis of Ewing family of tumors. Arch Pathol Lab Med; 2006 Dec;130(12):1813-8
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  • OBJECTIVE: To do a comparative analysis of 32 cases with EWS-FLI1: Ewing family of tumors (n = 30), desmoplastic small round cell tumor (n = 1), and undifferentiated sarcoma (n = 1).
  • RESULTS: The 19 male and 13 female patients had bone (n = 19) or soft tissue (n = 13) tumors.
  • Histologic groups were typical Ewing sarcoma (n = 15), atypical Ewing sarcoma (n = 4), Askin Rosai tumors (n = 5), desmoplastic small round cell tumor (n = 1), undifferentiated sarcoma (n = 1), and cases diagnosed as malignant small round cell tumors on FNAC (n = 6).
  • All tumors except desmoplastic small round cell tumor and undifferentiated sarcoma were CD99 positive.
  • EWS-FLI1 by reverse transcriptase polymerase chain reaction was noted in 15 cases of typical Ewing sarcoma, 4 cases of atypical Ewing sarcoma, 5 cases of Askin Rosai tumor, and no cases of desmoplastic small round cell tumor or undifferentiated sarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence. Reverse Transcriptase Polymerase Chain Reaction / methods. Sarcoma, Ewing / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Carcinoma, Small Cell / diagnosis. Child. Child, Preschool. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Oncogene Proteins, Fusion / analysis. Proto-Oncogene Protein c-fli-1 / analysis. RNA-Binding Protein EWS

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  • (PMID = 17149955.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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58. Ahlmann ER, Falkinstein Y, Fedenko AN, Menendez LR: Cryoablation and resection influences patient survival for soft tissue sarcomas: impact on survivorship and local recurrence. Clin Orthop Relat Res; 2007 Jun;459:174-81
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  • [Title] Cryoablation and resection influences patient survival for soft tissue sarcomas: impact on survivorship and local recurrence.
  • Cryosurgical ablation has been used successfully for treating various carcinomas and bone tumors; however, few studies report the use of cryosurgery followed by tumor resection for the treatment of soft tissue sarcomas.
  • We retrospectively reviewed 38 patients with no prior treatment for their neoplasm who underwent cryosurgery followed by wide excision of soft tissue sarcomas.
  • Cryosurgical ablation appears a safe and effective method of devitalizing tumor cells of soft tissue sarcomas.
  • [MeSH-major] Cryosurgery. Neoplasm Recurrence, Local / prevention & control. Sarcoma / mortality. Sarcoma / surgery. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Recovery of Function. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17415009.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Gürkan V, Ozger H: [Sarcomas of the hand]. Acta Orthop Traumatol Turc; 2007 Aug-Oct;41(4):286-90
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  • We evaluated patients who underwent surgical treatment for sarcoma of the hand.
  • METHODS: Between 1990 and 2006, eight patients (5 males, 3 females; mean age 39.6 years; range 26 to 67 years) with hand sarcoma received treatment at two centers.
  • The lesions arose from soft tissue in five cases, and from bone in three cases.
  • RESULTS: Mortality occurred in two patients due to multiple metastases, who had synovial sarcoma in the carpal region and clear cell sarcoma in the wrist, respectively.
  • Apart from clear cell sarcoma, diagnoses of other wrist tumors were stage IIB epithelioid sarcoma and malignant fibrous histiocytoma.
  • [MeSH-major] Hand. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Severity of Illness Index. Treatment Outcome. Turkey / epidemiology

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  • (PMID = 18180558.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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60. Flannery T, Kano H, Niranjan A, Monaco EA 3rd, Flickinger JC, Kofler J, Lunsford LD, Kondziolka D: Gamma knife radiosurgery as a therapeutic strategy for intracranial sarcomatous metastases. Int J Radiat Oncol Biol Phys; 2010 Feb 1;76(2):513-9
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  • The primary pathology was metastatic leiomyosarcoma (4 patients), osteosarcoma (3 patients), soft-tissue sarcoma (5 patients), chondrosarcoma (2 patients), alveolar soft part sarcoma (2 patients), and rhabdomyosarcoma, Ewing's sarcoma, liposarcoma, neurofibrosarcoma, and synovial sarcoma (1 patient each).
  • [MeSH-major] Brain Neoplasms / surgery. Radiosurgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Survival Rate. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19467792.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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61. Clark MA, Johnson MB, Thway K, Fisher C, Thomas JM, Hayes AJ: Clear cell sarcoma (melanoma of soft parts): The Royal Marsden Hospital experience. Eur J Surg Oncol; 2008 Jul;34(7):800-4
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  • [Title] Clear cell sarcoma (melanoma of soft parts): The Royal Marsden Hospital experience.
  • INTRODUCTION: Clear cell sarcoma (CCS) is a rare tumour with a propensity for local recurrence and nodal metastasis.
  • METHODS: Patients with a histopathologic diagnosis of CCS were identified from prospective histopathology and sarcoma databases and supplemented with a retrospective analysis of the patients' hospital records.
  • [MeSH-major] Sarcoma, Clear Cell. Soft Tissue Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Combined Modality Therapy. Female. Great Britain / epidemiology. Humans. Lower Extremity. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prognosis. Retrospective Studies. Survival Rate. Upper Extremity

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  • (PMID = 18042498.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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62. Krasin MJ, Davidoff AM, Xiong X, Wu S, Hua CH, Navid F, Rodriguez-Galindo C, Rao BN, Hoth KA, Neel MD, Merchant TE, Kun LE, Spunt SL: Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma. Int J Radiat Oncol Biol Phys; 2010 Mar 1;76(3):874-8
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  • [Title] Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma.
  • PURPOSE: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS).
  • Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 19625137.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; None / None / / P30 CA021765-31; United States / NCI NIH HHS / CA / P30 CA021765-31
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS133810; NLM/ PMC2823850
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63. Evans SM, Fraker D, Hahn SM, Gleason K, Jenkins WT, Jenkins K, Hwang WT, Zhang P, Mick R, Koch CJ: EF5 binding and clinical outcome in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys; 2006 Mar 1;64(3):922-7
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  • [Title] EF5 binding and clinical outcome in human soft tissue sarcomas.
  • PURPOSE: To study the 2-nitroimidazole agent EF5 as a surrogate for measuring hypoxia in a series of patients with soft tissue sarcomas, and to determine whether hypoxia measured with this technique was associated with patient outcome.
  • METHODS AND MATERIALS: Patients with soft tissue sarcomas of the head and neck, extremity, trunk, or retroperitoneum for whom surgical excision was the initial treatment of choice, were given 21 mg/kg EF5 24-48 hours before surgery.
  • [MeSH-major] Cell Hypoxia / physiology. Etanidazole / analogs & derivatives. Hydrocarbons, Fluorinated / metabolism. Indicators and Reagents / metabolism. Neoplasm Recurrence, Local / metabolism. Sarcoma / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Survival Analysis. Treatment Outcome

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  • (PMID = 16458778.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00040; United States / NCI NIH HHS / CA / R01 CA 75285
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; 0 / Hydrocarbons, Fluorinated; 0 / Indicators and Reagents; 30DKA3Q1HL / Etanidazole
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64. Singh RP, Grimer RJ, Bhujel N, Carter SR, Tillman RM, Abudu A: Adult head and neck soft tissue sarcomas: treatment and outcome. Sarcoma; 2008;2008:654987
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  • [Title] Adult head and neck soft tissue sarcomas: treatment and outcome.
  • We have retrospectively analysed the experience of a musculoskeletal oncological unit in the management of adult head and neck soft tissue sarcomas from 1990 to 2005.
  • Adult head and neck soft tissue sarcomas have a high mortality rate with a high risk of local recurrence and metastatic disease.

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  • (PMID = 18382622.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2276692
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65. Canter RJ, Beal S, Borys D, Martinez SR, Bold RJ, Robbins AS: Interaction of histologic subtype and histologic grade in predicting survival for soft-tissue sarcomas. J Am Coll Surg; 2010 Feb;210(2):191-198.e2
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  • [Title] Interaction of histologic subtype and histologic grade in predicting survival for soft-tissue sarcomas.
  • BACKGROUND: Histologic grade is considered the paramount prognostic factor in predicting survival for soft-tissue sarcomas (STS).
  • Increasing data suggest that histologic type substantially impacts STS behavior.
  • STUDY DESIGN: The Surveillance, Epidemiology, and End Results program was used to identify 17,364 cases of STS diagnosed between 1988 and 2004.
  • Using death from STS as 1 of the outcomes variables, histologic types were grouped into 3 categories: favorable (survival >or= 20% above the mean), neutral (survival within 20% of the mean), and unfavorable (survival >or= 20% below the mean).
  • RESULTS: Among 73 histologic types, malignant fibrous histiocytoma (24.1%); leiomyosarcoma, not otherwise specified (14.8%); sarcoma, not otherwise specified (12.8%); and myxoid liposarcoma (5.9%) were the most prevalent.
  • Risk of death from STS increased with increasing grade: 8.0% for low, 25.9% for intermediate, and 38.3% for high.
  • Among low-grade tumors, risk of death from STS ranged from 4.3% for favorable types to 15.3% for unfavorable types.
  • Among intermediate-grade tumors, risk of death from STS ranged from 6.0% for favorable types to 45.4% for unfavorable types.
  • Among high-grade tumors, risk of death from STS ranged from 24.3% for favorable types to 58.9% for unfavorable types.
  • CONCLUSIONS: Within categories of STS grade, there are substantial differences in survival, depending on histologic type.
  • Histologic type is an important predictor of biologic behavior in STS.
  • [MeSH-major] Sarcoma / mortality. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Cohort Studies. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Retrospective Studies. Risk Factors. SEER Program. Survival Rate. United States

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  • (PMID = 20113939.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Hartmann JT, Oechsle K, Huober J, Jakob A, Azemar M, Horger M, Kanz L, Bokemeyer C: An open label, non-comparative phase II study of gemcitabine as salvage treatment for patients with pretreated adult type soft tissue sarcoma. Invest New Drugs; 2006 May;24(3):249-53
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  • [Title] An open label, non-comparative phase II study of gemcitabine as salvage treatment for patients with pretreated adult type soft tissue sarcoma.
  • BACKGROUND: The number of effective cytotoxic agents for the treatment of patients with metastatic adult type soft tissue sarcoma (STS) is limited, when patients have failed anthracyline-based chemotherapy.
  • CONCLUSIONS: Considering response and progression-free rate as the primary endpoints for phase II trials in pretreated STS, gemcitabine has moderate efficacy.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Male. Middle Aged


67. Abatzoglou S, Turcotte RE, Adoubali A, Isler MH, Roberge D: Local recurrence after initial multidisciplinary management of soft tissue sarcoma: is there a way out? Clin Orthop Relat Res; 2010 Nov;468(11):3012-8
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  • [Title] Local recurrence after initial multidisciplinary management of soft tissue sarcoma: is there a way out?
  • BACKGROUND: Multimodality treatment of primary soft tissue sarcoma by expert teams reportedly affords a low incidence of local recurrence.
  • QUESTIONS/PURPOSES: We (1) determined the incidence of local recurrence from soft tissue sarcoma;.
  • METHODS: From our prospective database, we identified 618 soft tissue sarcomas.
  • CONCLUSIONS: Patients with a local recurrence of a soft tissue sarcoma have a poor prognosis.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Orthopedic Procedures. Patient Care Team. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Amputation. Chi-Square Distribution. Databases as Topic. Female. Humans. Incidence. Kaplan-Meier Estimate. Limb Salvage. Male. Middle Aged. Neoplasm Staging. Quebec. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Risk Assessment. Risk Factors. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20700676.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2947683
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68. Saito N, Tsutsumida A, Furukawa H, Sekido M, Oyama A, Funayama E, Saito A, Yamamoto Y: Reconstructive considerations in the treatment of soft tissue sarcomas of the cheek. Acta Otorhinolaryngol Ital; 2010 Apr;30(2):103-6
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  • [Title] Reconstructive considerations in the treatment of soft tissue sarcomas of the cheek.
  • Soft tissue sarcomas of the head and neck region are rare, and very little has been described about the reconstructive methods used after sarcoma resection of cheek soft tissue sarcomas.
  • Reconstructive methods for cheek defects after sarcoma resection are presented and the possibilities, advantages, disadvantages, and expected results are described.
  • A series of 3 patients with cheek soft tissue sarcomas were examined.
  • [MeSH-major] Cheek. Facial Neoplasms / surgery. Reconstructive Surgical Procedures. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Middle Aged

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  • (PMID = 20559481.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2882148
  • [Keywords] NOTNLM ; Cervicofacial flap / Cheek / Soft tissue sarcoma / Surgical treatment
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69. Altan E, Bitik B, Kalpakci Y, Dogan E, Altundag K: Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee. J Altern Complement Med; 2009 Feb;15(2):113
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  • [Title] Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee.
  • [MeSH-major] Drug-Induced Liver Injury / etiology. Nerium / adverse effects. Plant Extracts / adverse effects. Sarcoma, Synovial. Soft Tissue Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Fatal Outcome. Female. Humans. Injections, Intramuscular. Knee Joint. Lung Neoplasms / secondary

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  • (PMID = 19216656.001).
  • [ISSN] 1557-7708
  • [Journal-full-title] Journal of alternative and complementary medicine (New York, N.Y.)
  • [ISO-abbreviation] J Altern Complement Med
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Plant Extracts
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70. Schreiber D, Bell RS, Wunder JS, O'Sullivan B, Turcotte R, Masri BA, Davis AM: Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma. Qual Life Res; 2006 Nov;15(9):1439-46
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  • [Title] Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma.
  • OBJECTIVE: To evaluate how functional disability impacts on health related quality of life (HRQOL) of patients with extremity soft tissue sarcoma (STS) at 1 year post-surgery.
  • DESIGN AND SETTING: Survey of extremity STS patients pre-surgery and one-year post-treatment.
  • PARTICIPANTS: 100 participants who were treated for extremity STS between 2001 and 2003 at four Canadian hospitals.
  • [MeSH-major] Activities of Daily Living. Quality of Life. Sarcoma / psychology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Canada. Databases, Factual. Disability Evaluation. Female. Humans. Linear Models. Male. Middle Aged. Multicenter Studies as Topic. Postoperative Period. Severity of Illness Index. Surveys and Questionnaires

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  • (PMID = 16732468.001).
  • [ISSN] 0962-9343
  • [Journal-full-title] Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
  • [ISO-abbreviation] Qual Life Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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71. Penel N, Grosjean J, Robin YM, Vanseymortier L, Clisant S, Adenis A: Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases. Sarcoma; 2008;2008:459386
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  • [Title] Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases.
  • Soft tissue sarcomas are rare tumours with infrequent identified aetiological factors.
  • Several genetic syndromes as well as previous radiation therapy and/or chronic lymphoedema have been suspected to predispose to some soft tissue sarcomas.
  • Between January 1997 and September 2005, we carried out a prospective descriptive study to estimate the frequency of some particular etiological factors among 658 patients with soft tissue sarcomas.
  • Finally, most of the adult soft tissue sarcomas are not related to any classical clinically identified genetic disease or previous radiation therapy and/or chronic lymphoedema risk factors.
  • Frequency of underlying genetic syndrome which may predispose to soft tissue sarcomas could be higher than previously reported.

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  • (PMID = 18497869.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2386887
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72. Ohmiya N, Taguchi A, Mabuchi N, Itoh A, Hirooka Y, Niwa Y, Goto H: MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis. J Clin Oncol; 2006 Sep 20;24(27):4434-40
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  • PURPOSE: Recently, a single-nucleotide polymorphism in the MDM2 promoter (SNP309) has been found to lower the age of onset of tumors and increase the occurrence of multiple primary tumors in Li-Fraumeni syndrome, and accelerate the development of sporadic adult soft tissue sarcoma.
  • Tumor tissue was immunostained with p53 and examined for mutations in exons 5 to 8 of p53 using polymerase chain reaction-based single strand conformational polymorphism analysis and direct sequencing.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Genes, p53. Genetic Markers / genetics. Genetic Predisposition to Disease. Genotype. Humans. Male. Middle Aged. Mutation. Odds Ratio. Polymerase Chain Reaction. Polymorphism, Single Nucleotide. Polymorphism, Single-Stranded Conformational. Predictive Value of Tests. Prognosis. Promoter Regions, Genetic. Risk Assessment. Risk Factors. Survival Analysis

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  • (PMID = 16983111.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Genetic Markers; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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73. Armstrong AV Jr, Aedo A, Phelps S: Synovial sarcoma: a case report. Clin Podiatr Med Surg; 2008 Apr;25(2):167-81, vi
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  • [Title] Synovial sarcoma: a case report.
  • Synovial sarcoma most commonly affects adults in the third to fifth decades of life, and is the most common sarcoma of the foot.
  • This article discusses the case of a young patient who presented to the foot and ankle clinic with soft tissue swelling in the right foot, and the imaging protocol for such a patient.
  • A literature review of synovial sarcoma is also presented.
  • [MeSH-major] Foot Diseases / diagnosis. Sarcoma, Synovial / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Amputation. Artificial Limbs. Chemotherapy, Adjuvant. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18346589.001).
  • [ISSN] 0891-8422
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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74. Fiore M, Casali PG, Miceli R, Mariani L, Bertulli R, Lozza L, Collini P, Olmi P, Mussi C, Gronchi A: Prognostic effect of re-excision in adult soft tissue sarcoma of the extremity. Ann Surg Oncol; 2006 Jan;13(1):110-7
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  • [Title] Prognostic effect of re-excision in adult soft tissue sarcoma of the extremity.
  • BACKGROUND: We explored the outcome of patients with primary adult soft tissue sarcoma (STS) of the extremities undergoing re-excision after previous unplanned surgery.
  • METHODS: A total of 597 consecutive adult patients with primary extremity STS were treated with conservative surgery at our institution over a 20-year time span.
  • The assessed end points were sarcoma-specific mortality, local recurrence, and distant metastasis.
  • CONCLUSIONS: At a referral center with a liberal policy of re-excisions in adult primary STS of the extremities, the outcome of patients who underwent re-excision was similar to that of patients who had primary resections.
  • [MeSH-major] Neoplasm, Residual / surgery. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Combined Modality Therapy. Extremities. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Radiotherapy, Adjuvant. Regression Analysis. Reoperation. Treatment Outcome

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  • (PMID = 16372156.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Nicolas M, Moran CA, Suster S: Pulmonary metastasis from liposarcoma: a clinicopathologic and immunohistochemical study of 24 cases. Am J Clin Pathol; 2005 Feb;123(2):265-75
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  • Most PLs (6/8) were nonlipogenic and resembled an undifferentiated pleomorphic sarcoma.
  • [MeSH-major] Liposarcoma / secondary. Lung Neoplasms / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 15842053.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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76. Gallia GL, Sciubba DM, Hann CL, Raman SP, Westra WH, Tufaro AP, Olivi A: Synovial sarcoma of the frontal sinus. Case report. J Neurosurg; 2005 Dec;103(6):1077-80
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  • [Title] Synovial sarcoma of the frontal sinus. Case report.
  • Synovial sarcoma is a soft-tissue lesion occurring predominantly in the extremities of young adults.
  • Although the head and neck region is the second most common site of involvement, synovial sarcoma has rarely been reported in the paranasal sinus.
  • The authors present a case of synovial sarcoma arising from the frontal sinus and review the literature of synovial sarcomas arising from the paranasal sinuses.
  • [MeSH-major] Frontal Sinus. Paranasal Sinus Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 16381195.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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77. Nascimento AF, Bertoni F, Fletcher CD: Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. Am J Surg Pathol; 2007 Jan;31(1):99-105
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  • Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas of elderly patients and has a predilection for the limbs.
  • In 10 cases, the tumor was located in subcutaneous tissue and in 6 cases it was subfascial.
  • [MeSH-major] Epithelioid Cells / pathology. Fibrosarcoma / secondary. Sarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Extremities. Fatal Outcome. Female. Humans. Immunoenzyme Techniques. Liposarcoma / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Myoepithelioma / diagnosis. Rhabdomyosarcoma / diagnosis

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  • (PMID = 17197925.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Wakulińska A, Dembowska-Bagińska B, Cienciała M, Bothur-Nowacka J, Kościesza A, Pakuła-Kościesza I, Perek D: [Results of the treatment of paediatric non-rhabdomyosarcoma. One centre experience]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 1):819-29
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  • Non-rhabdomyosarcoma soft tissue sarcomas (NR STS) are a rare group of neoplasms of mesenchymal origin.
  • THE AIM of our study was to analyze methods and treatment results of patients with NR STS treated in our centre.
  • MATERIALS AND METHODS: Between 1996 and 2004, 64 patients with NR-STS, aged 2.5-21.5 yrs, were treated in our institution.
  • High number of patients with stage IV disease at diagnosis, occurrence of distant relapses and good response to chemotherapy indicate the necessity for the use of chemotherapy in patients with NR STS.
  • [MeSH-major] Sarcoma / epidemiology. Sarcoma / therapy. Soft Tissue Neoplasms / epidemiology. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Male. Poland / epidemiology. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 17317913.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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79. Van Damme JP, Schmitz S, Machiels JP, Galant C, Grégoire V, Lengelé B, Hamoir M: Prognostic factors and assessment of staging systems for head and neck soft tissue sarcomas in adults. Eur J Surg Oncol; 2010 Jul;36(7):684-90
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  • [Title] Prognostic factors and assessment of staging systems for head and neck soft tissue sarcomas in adults.
  • OBJECTIVES: The primary objectives of this study were to analyse the outcome of patients diagnosed with head and neck soft tissue sarcomas (HNSTS) and to identify relevant prognostic factors.
  • METHODS: From 07/1988 to 01/2008, the charts of 42 adult patients were retrospectively reviewed.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Risk Assessment. Risk Factors

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  • (PMID = 20542404.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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80. Pfannschmidt J, Klode J, Muley T, Dienemann H, Hoffmann H: Pulmonary metastasectomy in patients with soft tissue sarcomas: experiences in 50 patients. Thorac Cardiovasc Surg; 2006 Oct;54(7):489-92
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  • [Title] Pulmonary metastasectomy in patients with soft tissue sarcomas: experiences in 50 patients.
  • BACKGROUND: Pulmonary resection of metastatic soft tissue sarcomas is an accepted method of treatment.
  • METHODS: Between 1996 and 2001, 50 patients (27 men, 23 women) with pulmonary metastases from a soft tissue sarcoma underwent surgical resection.
  • CONCLUSION: We conclude that pulmonary resection of metastatic soft tissue sarcomas is a safe and effective treatment, which offers an improved survival benefit.
  • [MeSH-major] Lung Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 17089318.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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81. Kayton ML, Delgado R, Busam K, Cody HS 3rd, Athanasian EA, Coit D, La Quaglia MP: Experience with 31 sentinel lymph node biopsies for sarcomas and carcinomas in pediatric patients. Cancer; 2008 May 1;112(9):2052-9
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  • No other patients had positive sentinel lymph nodes, and among those with nonrhabdomyosarcoma soft-tissue sarcomas there were no lymph node basin recurrences despite a lack of lymph node basin irradiation or formal lymph node dissection.
  • CONCLUSIONS: Sentinel lymph node biopsy for pediatric soft-tissue tumors can be performed safely, and the results can alter treatment decisions both for children with rhabdomyosarcoma and adolescents with breast cancer.
  • In patients with nonrhabdomyosarcoma soft-tissue sarcoma, we observed no positive sentinel lymph nodes and no lymph node basin recurrences; these data should prompt the prospective study of sentinel lymph node biopsy as a modality that might help guide the administration or withholding of regional therapy among pediatric patients with nonrhabdomyosarcoma soft-tissue sarcoma.
  • [MeSH-major] Carcinoma / pathology. Sarcoma / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adolescent. Adult. Breast Neoplasms / pathology. Child. Child, Preschool. Female. Humans. Lymphography. Male. Middle Aged. Retrospective Studies. Rhabdomyosarcoma / pathology. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Clear Cell / pathology

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  • (PMID = 18338809.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Yang J, Yang D, Cogdell D, Du X, Li H, Pang Y, Sun Y, Hu L, Sun B, Trent J, Chen K, Zhang W: APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival. Technol Cancer Res Treat; 2010 Apr;9(2):161-9
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  • We sought to gain insight into the role of APEX1 in human osteosarcoma by evaluation of gene copy number alterations and its protein expression in osteosarcoma patients treated at the Sarcoma Center of Tianjin Cancer Hospital (Tianjin, China).
  • To evaluate the gene copy number alterations of APEX1, we acquired 10 fresh tissue samples from 9 patients and performed whole-genome array-based comparative genomic hybridization (aCGH).
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Disease-Free Survival. Female. Gene Amplification. Gene Dosage. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Male. Neoplasm Staging. Prognosis. Young Adult


83. Ruka W, Rutkowski P, Morysiński T, Nowecki Z, Zdzienicki M, Makula D, Ptaszyński K, Bylina E, Grzesiakowska U: The megavoltage radiation therapy in treatment of patients with advanced or difficult giant cell tumors of bone. Int J Radiat Oncol Biol Phys; 2010 Oct 1;78(2):494-8
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  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Radiotherapy Dosage. Treatment Outcome. Tumor Burden. Young Adult

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20004531.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Khademi B, Mohammadianpanah M, Ashraf MJ, Yeganeh F: Synovial sarcoma of the parapharyngeal space. Auris Nasus Larynx; 2007 Mar;34(1):125-9
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  • [Title] Synovial sarcoma of the parapharyngeal space.
  • Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space.
  • Pathologic report disclosed the diagnosis of synovial sarcoma.
  • [MeSH-major] Pharyngeal Neoplasms / radiotherapy. Pharyngeal Neoplasms / surgery. Sarcoma, Synovial / radiotherapy. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Radiotherapy Dosage

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  • (PMID = 17056221.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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85. Balkan İ, Ozaras R, Mert A: Infected Kaposi's sarcoma. Intern Med; 2010;49(23):2649
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  • [Title] Infected Kaposi's sarcoma.
  • [MeSH-major] Enterococcus faecalis. Gram-Positive Bacterial Infections / diagnosis. Sarcoma, Kaposi / diagnosis. Soft Tissue Infections / diagnosis
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 21139313.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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86. Comin CE, Novelli L, Tornaboni D, Messerini L: Clear cell sarcoma of the ileum: report of a case and review of literature. Virchows Arch; 2007 Oct;451(4):839-45
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  • [Title] Clear cell sarcoma of the ileum: report of a case and review of literature.
  • Clear cell sarcoma (CCS) is a high grade soft tissue sarcoma with a distinct molecular profile and with morphological features resembling those of melanoma.
  • CCS has been rarely described in other locations other than the soft tissues, including the gastrointestinal tract.
  • Fluorescence in situ hybridization analysis demonstrated the presence of a t(12;22)(q13;q12) translocation, the diagnostic hallmark of CCS of soft parts.
  • The present case, together with a detailed review of the literature on this topic, demonstrates that the gastrointestinal tract is a possible site of CCS of soft tissues and that making a reliable diagnosis of this tumor requires cytogenetic or molecular diagnostic investigations.
  • [MeSH-major] Ileal Neoplasms / diagnosis. Sarcoma, Clear Cell / diagnosis
  • [MeSH-minor] Adult. Female. Humans. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 17636326.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 30
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87. Kumar R, Rekhi B, Shirazi N, Pais A, Amare P, Gawde D, Jambhekar N: Spectrum of cytomorphological features, including literature review, of an extraskeletal myxoid chondrosarcoma with t(9;22)(q22;q12) (TEC/EWS) results in one case. Diagn Cytopathol; 2008 Dec;36(12):868-75
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  • Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon soft tissue sarcoma with evolving literature on its cytomorphological features and limited documentation of its molecular analysis.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18925568.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA-Binding Protein EWS
  • [Number-of-references] 29
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88. Kasper B, Ho AD, Egerer G: Dose-intensive chemotherapy with stem cell support as a treatment strategy for bone and soft-tissue sarcomas. Curr Stem Cell Res Ther; 2006 Jan;1(1):29-35
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  • [Title] Dose-intensive chemotherapy with stem cell support as a treatment strategy for bone and soft-tissue sarcomas.
  • Whether high-dose chemotherapy with stem cell support improves the long-term outcome for patients with bone and soft-tissue sarcoma is debatable and controversial.
  • Prognosis of patients with unresectable or advanced metastatic sarcoma remains poor with a disease-free survival at 5 years less than 10%; treatment is generally considered to be palliative.
  • However, all studies were not randomized, comprised small patient numbers and included heterogeneous histological subtypes of soft-tissue sarcomas.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bone Neoplasms / therapy. Sarcoma / therapy. Stem Cell Transplantation
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Humans. Middle Aged. Neoplasm Metastasis. Sarcoma, Ewing / therapy. Survival Analysis

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  • (PMID = 18220851.001).
  • [ISSN] 1574-888X
  • [Journal-full-title] Current stem cell research & therapy
  • [ISO-abbreviation] Curr Stem Cell Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United Arab Emirates
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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89. Hussein R, Smith MA: Soft tissue sarcomas: are current referral guidelines sufficient? Ann R Coll Surg Engl; 2005 May;87(3):171-3
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  • [Title] Soft tissue sarcomas: are current referral guidelines sufficient?
  • INTRODUCTION: To investigate the adequacy of current early referral guidelines for patients with extremity soft tissue sarcomas.
  • PATIENTS & METHODS: 365 patients with confirmed soft tissue sarcomas were evaluated.
  • CONCLUSION: Although the majority of soft tissue sarcomas in our patients had one or more of the clinical guideline features, there was still an unacceptable delay in referring these patients to a specialist unit.
  • This combined with increased awareness of these guidelines and a well-advertised, open-access clinic linked to a specialist unit should allow for a more rapid evaluation of soft tissue tumours.
  • [MeSH-major] Practice Guidelines as Topic / standards. Referral and Consultation / standards. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. London. Male. Middle Aged. Pain / etiology. Prospective Studies. Time Factors

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  • (PMID = 15901376.001).
  • [ISSN] 0035-8843
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1963892
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90. Mulrooney DA, Yeazel MW, Kawashima T, Mertens AC, Mitby P, Stovall M, Donaldson SS, Green DM, Sklar CA, Robison LL, Leisenring WM: Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ; 2009 Dec 08;339:b4606
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  • [Title] Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort.
  • OBJECTIVES: To assess the incidence of and risks for congestive heart failure, myocardial infarction, pericardial disease, and valvular abnormalities among adult survivors of childhood and adolescent cancers.
  • PARTICIPANTS: 14,358 five year survivors of cancer diagnosed under the age of 21 with leukaemia, brain cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, kidney cancer, neuroblastoma, soft tissue sarcoma, or bone cancer between 1970 and 1986.
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Case-Control Studies. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Prognosis. Retrospective Studies. United States. Young Adult

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  • (PMID = 19996459.001).
  • [ISSN] 1756-1833
  • [Journal-full-title] BMJ (Clinical research ed.)
  • [ISO-abbreviation] BMJ
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U24 CA 55727; United States / NCI NIH HHS / CA / U24 CA055727; United States / NCRR NIH HHS / RR / 1K12RR023247; United States / NCI NIH HHS / CA / U24 CA055727-17; United States / NCRR NIH HHS / RR / K12 RR023247-05; United States / NCRR NIH HHS / RR / K12 RR023247
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3266843
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91. Thanakit V, Nelson SD, Udomsawaengsup S: Round cell liposarcoma of scrotum with indolent course in young adult. J Med Assoc Thai; 2005 Sep;88(9):1302-7
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  • [Title] Round cell liposarcoma of scrotum with indolent course in young adult.
  • Round cell liposarcoma is highly metastatic and is classified as high grade and poorly differentiated myxoid sarcoma.
  • Most masses within the scrotal sac arise from the testis proper, and less likely from the extratesticular tissue.
  • Myxoid/round cell liposarcoma and round cell liposarcoma are rarely encounter in extratesticular soft tissue.
  • We reported a rare case of round cell liposarcoma (high grade myxoid liposarcoma) of extratesticular tissue.
  • To our knowledge, this is the first case of a large size (> 5cm) round cell liposarcoma arising from soft tissue within the scrotal sac of young adult with indolent course.
  • Simple excision or enucleation are inadequate therapies and wide excision of the hemiscrotum including inguinal soft tissue and nodes is recommended.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Prognosis. Scrotum / pathology. Testicular Hydrocele / pathology

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  • (PMID = 16536120.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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92. Zamani F, Jabbari M, Alimohamadi SM, Shakeri R, Rostami Z, Abedi B, Hormazdi M, Malekzadeh R: Primary alveolar soft part sarcoma of chest wall: a case report and review of the literature. MedGenMed; 2006;8(3):2
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  • [Title] Primary alveolar soft part sarcoma of chest wall: a case report and review of the literature.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Soft Tissue Neoplasms / diagnosis. Thoracic Wall
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Fatal Outcome. Female. Humans. Lung Neoplasms / secondary. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 17406145.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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93. Georgalas C, Kapoor L, Chau H, Bhattacharyya A: Inflammatory focal myositis of the sternomastoid muscle: is there an absolute indication for biopsy? A case report and review of the literature. Eur Arch Otorhinolaryngol; 2006 Feb;263(2):149-51
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  • Focal myositis is a localised inflammatory process affecting skeletal muscles belonging to the pathological group of inflammatory pseudo tumours of soft tissue that includes myositis ossificans, proliferative myositis and nodular pseudosarcomatous fasciitis.
  • Very rarely, it may affect one of the neck muscles and present as a neck lump, in which case both the clinical and pathological picture can mimic a sarcoma.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 16362267.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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94. Maurel J, López-Pousa A, de Las Peñas R, Fra J, Martín J, Cruz J, Casado A, Poveda A, Martínez-Trufero J, Balañá C, Gómez MA, Cubedo R, Gallego O, Rubio-Viqueira B, Rubió J, Andrés R, Sevilla I, de la Cruz JJ, Del Muro XG, Buesa JM: Efficacy of sequential high-dose doxorubicin and ifosfamide compared with standard-dose doxorubicin in patients with advanced soft tissue sarcoma: an open-label randomized phase II study of the Spanish group for research on sarcomas. J Clin Oncol; 2009 Apr 10;27(11):1893-8
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  • [Title] Efficacy of sequential high-dose doxorubicin and ifosfamide compared with standard-dose doxorubicin in patients with advanced soft tissue sarcoma: an open-label randomized phase II study of the Spanish group for research on sarcomas.
  • PURPOSE: To assess the progression-free survival (PFS) and antitumor response to standard-dose doxorubicin compared with sequential dose-dense doxorubicin and ifosfamide in first-line treatment of advanced soft tissue sarcoma.
  • PATIENTS AND METHODS: Patients with measurable advanced soft tissue sarcoma, Eastern Cooperative Oncology Group (ECOG) performance status (PS) < 2, between the ages 18 and 65 years, and with adequate bone marrow, liver, and renal function were entered in the study.
  • CONCLUSION: Single-agent doxorubicin remains the standard treatment in fit patients with advanced soft tissue sarcoma.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Doxorubicin / administration & dosage. Ifosfamide / administration & dosage. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Disease Progression. Dose-Response Relationship, Drug. Female. Humans. Male. Middle Aged. Remission Induction. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 19273704.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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95. Hantschke M, Mentzel T, Rütten A, Palmedo G, Calonje E, Lazar AJ, Kutzner H: Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma. Am J Surg Pathol; 2010 Feb;34(2):216-22
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  • [Title] Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma.
  • Clear cell sarcoma (CCS) of tendons and aponeuroses/malignant melanoma (MM) of soft parts is a rare tumor and in the majority of cases presents a characteristic reciprocal translocation t(12;22)(q13;q12) that results in fusion of the EWS and ATF1 genes.
  • CCS is classically regarded as a deep soft tissue tumor associated with tendons or aponeuroses.


96. Tsakonas GP, Kallistratos MS, Balamoti EK, Gassiamis A, Zizi-Sermpetzoglou A, Mylonakis N, Karabelis A, Kosmas C: Rare and aggressive metastatic, axial multifocal local epithelioid sarcoma associated with paraneoplastic granulocytosis and hypoglycaemia. Lancet Oncol; 2007 Jan;8(1):82-4
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  • [Title] Rare and aggressive metastatic, axial multifocal local epithelioid sarcoma associated with paraneoplastic granulocytosis and hypoglycaemia.
  • [MeSH-major] Granulocytes / pathology. Hypoglycemia. Paraneoplastic Syndromes. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / therapy


97. Riggi N, Stamenkovic I: The Biology of Ewing sarcoma. Cancer Lett; 2007 Aug 28;254(1):1-10
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  • [Title] The Biology of Ewing sarcoma.
  • They constitute some of the most aggressive adult and childhood cancers in that they have a high metastatic proclivity and are typically refractory to conventional chemo- and radiation therapy.
  • Ewing's sarcoma is a member of Ewing's family tumors (ESFT) and the second most common solid bone and soft tissue malignancy of children and young adults.
  • This review will highlight some of the most recent discoveries in the field of Ewing sarcoma biology and origins.
  • [MeSH-major] Sarcoma, Ewing / genetics. Sarcoma, Ewing / pathology

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  • (PMID = 17250957.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
  • [Number-of-references] 74
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98. Al Yami A, Griffin AM, Ferguson PC, Catton CN, Chung PW, Bell RS, Wunder JS, O'Sullivan B: Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary? Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):1191-7
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  • [Title] Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary?
  • PURPOSE: For patients with an extremity soft tissue sarcoma (STS) treated with preoperative radiotherapy and surgically excised with positive margins, we retrospectively reviewed whether a postoperative radiation boost reduced the risk of local recurrence (LR).
  • METHODS AND MATERIALS: A total of 216 patients with positive margins after resection of an extremity STS treated between 1986 and 2003 were identified from our institution's prospectively collected database.
  • [MeSH-major] Sarcoma / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amputation. Female. Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Benign Fibrous / prevention & control. Histiocytoma, Benign Fibrous / radiotherapy. Histiocytoma, Benign Fibrous / surgery. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / prevention & control. Leiomyosarcoma / radiotherapy. Leiomyosarcoma / surgery. Limb Salvage. Liposarcoma / pathology. Liposarcoma / prevention & control. Liposarcoma / radiotherapy. Liposarcoma / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm, Residual. Postoperative Care. Radiotherapy Dosage. Retreatment. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):959; author reply 959-60 [21621120.001]
  • (PMID = 20056340.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Saito R, Kumabe T, Watanabe M, Jokura H, Shibuya M, Nakazato Y, Tominaga T: Low-grade fibromyxoid sarcoma of intracranial origin. J Neurosurg; 2008 Apr;108(4):798-802
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  • [Title] Low-grade fibromyxoid sarcoma of intracranial origin.
  • The authors report on a 21-year-old man who presented with a low-grade fibromyxoid sarcoma primarily located in the right parietal lobe with diffuse infiltration.
  • The low-grade fibromyxoid sarcoma is a rare sarcoma of the deep soft tissue that is characterized as an indolent but metastasizing soft-tissue neoplasm with a deceptively benign histological appearance.
  • A high rate of local recurrence and eventual metastasis has been demonstrated for this tumor in deep soft tissue.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Sarcoma / diagnosis. Sarcoma / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Radiosurgery. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 18377261.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Baratti D, Pennacchioli E, Casali PG, Bertulli R, Lozza L, Olmi P, Collini P, Radaelli S, Fiore M, Gronchi A: Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol; 2007 Dec;14(12):3542-51
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  • [Title] Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution.
  • BACKGROUND: Epithelioid sarcoma (ES) is a rare subtype of soft-tissue sarcoma of unknown histogenesis.
  • [MeSH-major] Epithelioid Cells / pathology. Sarcoma / mortality. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17909905.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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