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1. Wahafu W, He ZS, Zhou LQ: [A case of adult Wilms' tumor]. Beijing Da Xue Xue Bao; 2008 Jun 18;40(3):334-8
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  • [Title] [A case of adult Wilms' tumor].
  • Abdominal ultrasound and computed tomography scan revealed a left renal mass.
  • Nephrectomy was performed, and a final diagnosis of adult Wilms' tumor was made based on histopathology and immunohistology.
  • Adult Wilms' tumor is the exceptional malignant renal tumor.
  • Only 1%-2% of Wilms' tumor is diagnosed in adult patients.
  • Because of unspecific tumor symptoms in adults, the diagnosis is frequently made by histology.
  • The diagnosis of adult Wilms' tumor is difficult to make preoperatively because diagnostic imaging only confirms the presence of a renal mass.
  • Having retrospected 6 cases of adult Wilms' tumor between 1950 and 2007 and reviewed related reports, we conclude that the proper strategies of adjuvant treatment as applied to childhood Wilms' tumor patients after surgery can conspicuously improve the outcome in adult patients.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Wilms Tumor / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Nephrectomy

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  • (PMID = 18560467.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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2. Omachi T, Tamada S, Ito T, Sakamoto W, Matsumura K, Nakatani T: [A case of adult Wilms' tumor --review of the Japanese literature]. Hinyokika Kiyo; 2006 Nov;52(11):851-4
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  • [Title] [A case of adult Wilms' tumor --review of the Japanese literature].
  • Right radical nephrectomy was performed with the diagnosis of right renal cancer.
  • Histopathological examination revealed Wilms' tumor of favorable histology, stage I according to the National Wilms Tumor Study classification.
  • Wilms' tumor is rare in adults and has a poor prognosis compared with that in children.
  • No difference was found between the left and right sides in frequency of tumor.
  • Based on these findings, we conclude that the prognosis of adult Wilms' tumor is very poor since many patients have unfavorable histology and no effective treatment guidelines have been established.
  • [MeSH-major] Kidney Neoplasms / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Female. Humans. Male

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  • (PMID = 17176867.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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3. Routh JC, Ashley RA, Sebo TJ, Lohse CM, Husmann DA, Kramer SA, Kwon ED: B7-H1 expression in Wilms tumor: correlation with tumor biology and disease recurrence. J Urol; 2008 May;179(5):1954-9; discussion 1959-60
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  • [Title] B7-H1 expression in Wilms tumor: correlation with tumor biology and disease recurrence.
  • PURPOSE: Despite tremendous gains in improving prognosis, 10% of patients with Wilms tumor will ultimately experience disease recurrence.
  • The identification of novel prognostic markers and tumor associated targets for patients at risk could enable clinicians to treat recurrences more aggressively and, thus, optimize outcomes.
  • We have previously shown that tumor expression of the T cell coregulatory ligand B7-H1 portends a poor prognosis for adults with renal cell carcinoma and represents a promising target to improve therapy.
  • We hypothesize that this finding may be true for Wilms tumor.
  • MATERIALS AND METHODS: We identified 81 patients with Wilms tumor treated at 1 institution between 1968 and 2004.
  • Histopathological features, including Wilms tumor B7-H1 expression, were correlated with clinical observations and outcome.
  • RESULTS: Tumor recurrences were noted in 22% of patients with Wilms tumor and 14% died.
  • B7-H1 was expressed in 11 tumors (14%) and was more likely to occur in anaplastic Wilms tumor (p = 0.03).
  • Tumor B7-H1 expression was associated with a 2.7-fold increased risk of recurrence, although this difference did not achieve statistical significance (p = 0.06).
  • CONCLUSIONS: B7-H1 is expressed by Wilms tumor, correlates with tumor biology and is associated with an increased risk of recurrence in patients with favorable histology tumors.
  • Multi-institutional studies to elucidate the role of B7-H1 in the treatment of Wilms tumor are warranted.
  • [MeSH-major] Antigens, CD / metabolism. Biomarkers, Tumor / analysis. Kidney Neoplasms / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD274. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Prognosis. Recurrence. Survival Rate

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  • (PMID = 18355839.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK100534; United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-01A1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / Biomarkers, Tumor; 0 / CD274 protein, human
  • [Other-IDs] NLM/ NIHMS160066; NLM/ PMC2789396
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4. Reinhard H, Furtwängler R, Siemer S, Wullich B, Graf N: [Wilms' tumor in adults]. Urologe A; 2007 Jul;46(7):748-53
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  • [Title] [Wilms' tumor in adults].
  • [Transliterated title] Wilms-Tumor bei Erwachsenen.
  • BACKGROUND: Wilms' tumor (nephroblastoma) is the most frequent renal tumor in childhood.
  • In contrast nephroblastoma in adults is rare, and the disease used to have a poor prognosis.
  • PATIENTS AND METHODS: Of 1,300 registered patients, a total of 41 patients older than 16 years were enrolled in the pediatric nephroblastoma trial from 1994 to 2005.
  • CONCLUSION: Adults with nephroblastoma have a very good prognosis if treated according to a pediatric protocol.
  • [MeSH-major] Kidney Neoplasms / drug therapy. Kidney Neoplasms / epidemiology. Risk Assessment / methods. Vincristine / therapeutic use. Wilms Tumor / drug therapy. Wilms Tumor / epidemiology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents, Phytogenic / therapeutic use. Female. Germany / epidemiology. Humans. Male. Middle Aged. Prevalence. Risk Factors. Treatment Outcome

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  • (PMID = 17505815.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine
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5. Khattar N, Kumar S, Dorairajan LN, Pal BC, Ram KK: Adult Wilms' tumor masquerading as pyonephrosis: a diagnostic dilemma. Indian J Surg; 2008 Oct;70(5):235-6

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  • [Title] Adult Wilms' tumor masquerading as pyonephrosis: a diagnostic dilemma.
  • In the era of modern imaging, modalities like ultrasonography, computed tomography and magnetic resonance imaging diagnosis of renal mass lesions has become more accurate.
  • Nevertheless, rare cases of renal adenocarcinoma and other primary renal tumors have been rarely reported to mimic pyonephrosis, renal abscess, perinephric abscess or tuberculosis.
  • We report, for the first time in literature, a case of Wilms' tumor mimicking as a case of pyonephrosis.

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  • (PMID = 23133070.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452405
  • [Keywords] NOTNLM ; Imaging / Perinephric abscess / Pyonephrosis / Wilms’ tumor
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6. Cotton CA, Peterson S, Norkool PA, Takashima J, Grigoriev Y, Green DM, Breslow NE: Early and late mortality after diagnosis of wilms tumor. J Clin Oncol; 2009 Mar 10;27(8):1304-9
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  • [Title] Early and late mortality after diagnosis of wilms tumor.
  • PURPOSE: To assess rates and causes of mortality in patients with Wilms tumor (WT).
  • METHODS: Through 2002, 6,185 patients enrolled onto the National Wilms Tumor Study between 1969 and 1995 were actively observed.
  • Deaths were classified on the basis of medical records as the result of original disease, late effects (including second malignant neoplasms [SMNs], cardiac causes, pulmonary disease, and renal failure), or other causes.

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  • (PMID = 19139431.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA054498; United States / NCI NIH HHS / CA / 2R01CA54498
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2667828
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7. Azzarello JT, Lin HK, Gherezghiher A, Zakharov V, Yu Z, Kropp BP, Culkin DJ, Penning TM, Fung KM: Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor. Int J Clin Exp Pathol; 2009 Nov 15;3(2):147-55
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  • [Title] Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor.
  • However, immunohistochemistry has demonstrated AKR1C3 in normal adult kidneys with expression in Bowman' capsule, the mesangial cells, proximal and distal tubules, as well as mature urothelial epithelium.
  • The significance of its spatial distribution and metabolic activities in the kidney remains undefined.
  • In addition to its ability to catalyze steroid hormones (including androgen, desoxycorticosterone, and progesterone) and involvement in prostaglandins metabolism, we suspect that AKR1C3 may function as a chemical barrier in the renal tubules for normal function in mature kidneys.
  • In this study, we demonstrate widespread expression of AKR1C3 in renal neoplasms with a phenotype recapitulating mature kidney (i.e., renal cell carcinoma) and urothelium also known as transitional epithelium (i.e., papillary urothelial carcinoma), but noted limited AKR1C3 expression in renal neoplasms with a phenotype recapitulating embryonic kidneys (i.e., Wilms' tumor).
  • Our results suggest that AKR1C3 may represent a developmental marker that is related to renal epithelium maturity.

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  • (PMID = 20126582.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES013508; United States / NCI NIH HHS / CA / R01 CA090744; United States / NCI NIH HHS / CA / 1R01-CA90744; United States / NIEHS NIH HHS / ES / P30-ES013508
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.- / 3-Hydroxysteroid Dehydrogenases; EC 1.1.1.- / AKR1C3 protein, human; EC 1.1.1.- / Hydroxyprostaglandin Dehydrogenases
  • [Other-IDs] NLM/ PMC2809994
  • [Keywords] NOTNLM ; Aldo-keto reductase / Wilms' tumor / kidney cancer / papillary urothelial carcinoma / renal cell carcinoma
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8. Okasho K, Nishiyama H, Watanabe J, Soda T, Mikami Y, Koyama T, Kamoto T, Ogawa O: Adult wilms tumor in the renal pelvis: case report with review of the literature. Urology; 2008 Nov;72(5):1185.e5-7
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  • [Title] Adult wilms tumor in the renal pelvis: case report with review of the literature.
  • Retroperitoneoscopic nephroureterectomy was performed because of a clinical diagnosis of renal pelvic carcinoma.
  • Pathologic examination led to a final diagnosis of an adult Wilms tumor arising from the renal pelvis.
  • This is the first report of a Wilms tumor in the renal pelvis of an adult patient.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / surgery. Kidney Pelvis. Wilms Tumor / diagnosis. Wilms Tumor / surgery

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  • (PMID = 18329072.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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9. Llarena Ibarguren R, Villafruela Mateos A, Azurmendi Arin I, García Fernández J, Olano Grasa I, Padilla Nieva J, Pertusa Peña C: [Nephroblastoma or Wilms tumor. Adult presentation. Report of two cases]. Arch Esp Urol; 2007 Jun;60(5):539-44
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  • [Title] [Nephroblastoma or Wilms tumor. Adult presentation. Report of two cases].
  • [Transliterated title] Nefroblastoma o tumor de Wilms. Presentación en adultos. Estudio de dos casos.
  • OBJECTIVES: To present to new cases of nephroblastoma or Wilms tumor diagnosed in adult age.
  • METHODS: The first case we report is a 16-year-old female with the diagnosis of stage I nephroblastoma after radical nephrectomy for a right renal mass.
  • The second case is a 33-year-old female with the diagnosis of nephroblastoma after percutaneous biopsy of a right renal mass.
  • CONCLUSIONS: This type of tumor typical of childhood is extremely rare in adult age, and despite worse survivals and more aggressiveness are described, they may be treated with the same protocols used in children, following any of the two big co-operative groups: American NWTS or European SIOP.
  • [MeSH-major] Kidney Neoplasms. Wilms Tumor
  • [MeSH-minor] Adolescent. Adult. Female. Humans

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  • (PMID = 17718208.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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10. Martínez Mansur R, Piana M, Codone J, Díez M, Elizalde F, Reyes E, Villeta M, Lioy Lupis M, Solano F, Serrano A, Proto J, Sicher R: [Wilms tumor in an adult patient: case report]. Arch Esp Urol; 2006 Jul-Aug;59(6):632-4
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  • [Title] [Wilms tumor in an adult patient: case report].
  • [Transliterated title] Tumor de Wilms en paciente adulto presentación de un caso.
  • Nephroblastoma or Wilms tumor is the most common renal neoplasia in children, representing 1/5 of the malignant tumors in this group.
  • Nevertheless, the incidence of such tumor in adults is much rarer with less than 250 cases reported.
  • Currently, the therapeutic options derive from the National Wilms Tumor Study (NWTS).
  • [MeSH-major] Kidney Neoplasms / diagnosis. Wilms Tumor / diagnosis

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  • (PMID = 16933494.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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11. Fischer N, Bastian PJ, Ellinger J, Simon A, Bode U, Biermann K, Hadizadeh D, Müller SC: [Pediatric renal cell carcinoma. A rare differential diagnosis of Wilms' tumor]. Urologe A; 2008 May;47(5):620-3
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  • [Title] [Pediatric renal cell carcinoma. A rare differential diagnosis of Wilms' tumor].
  • [Transliterated title] Das Nierenzellkarzinom beim Kind. Eine seltene Differenzialdiagnose zum Wilms-Tumor.
  • Renal cell carcinoma (RCC) is a very rare pediatric disease and should be treated as an entity of its own because of differences in symptoms, therapy, and prognosis from the adult form of the disease.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Wilms Tumor / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Dactinomycin / administration & dosage. Diagnosis, Differential. Humans. Kidney / pathology. Lymph Node Excision. Lymph Nodes / pathology. Magnetic Resonance Imaging. Male. Neoadjuvant Therapy. Neoplasm Staging. Nephrectomy. Ultrasonography. Vincristine / administration & dosage


12. Karim ME, Momen MA, Akhter S, Haque Z, Islam T, Haque MM, Hossain M: Wilms tumor in adult. Mymensingh Med J; 2010 Apr;19(2):299-302
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  • [Title] Wilms tumor in adult.
  • Wilms Tumor (WT) is a very rare malignancy in adults representing 1% of all renal neoplasms.
  • It is however the most common renal tumor of children and adult patients are treated like pediatric cases.
  • Bilateral tumors occur in 5% of adult cases.
  • As clinical presentation of WT is similar to that of renal cell carcinoma (RCC), it tends to be an unsuspected pathological diagnosis in most cases.
  • The diagnosis of the tumor needs positive sonographic and computed tomography (CT) findings with histopathological confirmation.
  • Prognosis of adult WT is relatively poor and resistant to chemotherapy.
  • We present a case of wilms tumor in a 68 years old male patient with right sided non tender abdominal mass and occasional flank pain.
  • The patient was normotensive but hematuric and radiological findings suggested right renal mass with enlarged lymph node and histopathological analysis revealed nephroblastoma associated with lymph node metastases.

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  • (PMID = 20395930.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
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13. Seo J, Suh YL, Choi HY: Adult teratoid Wilms' tumor with prominent neuroepithelial differentiation. Pathol Int; 2009 Jan;59(1):44-8
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  • [Title] Adult teratoid Wilms' tumor with prominent neuroepithelial differentiation.
  • Teratoid Wilms' tumor is a rare variant of Wilms' tumor (WT) that has been reported exclusively in pediatric patients.
  • The present paper describes a teratoid WT in a 50-year-old Korean man with a giant right renal mass.
  • Radical nephrectomy was performed under the impression that the mass was a renal cell carcinoma.
  • Grossly, the removed kidney contained a giant well-encapsulated mass measuring 24 x 18 x 10 cm with cystic changes, necrosis, and hemorrhage.
  • This is the first reported case of a teratoid WT occurring in an adult kidney.
  • [MeSH-major] Kidney Neoplasms / pathology. Teratoma / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 19121091.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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14. Rodrigues FA, Ribeiro EC, Maroccolo Filho R, Silva EA, Diaz FA: Adult Wilms tumor during gestational period. Urology; 2009 Apr;73(4):929.e1-2
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  • [Title] Adult Wilms tumor during gestational period.
  • Magnetic resonance imaging showed a solid left renal mass.
  • The patient had a radical nephrectomy during the 20th week gestation and the diagnosis was nephroblastoma.
  • Based on the excellent results achieved while treating children with Wilms' tumor using surgery, chemotherapy and radiotherapy, adults with the same disease should be treated similarly.
  • [MeSH-major] Kidney Neoplasms. Pregnancy Complications, Neoplastic. Wilms Tumor
  • [MeSH-minor] Adolescent. Female. Humans. Kidney / injuries. Pregnancy

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  • (PMID = 18722653.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Escudero A, Flo A, Espí C, Moret E, Massó E, Cubells C: [Anesthesia in 2 cases of resection of a renal tumor involving the vena cava]. Rev Esp Anestesiol Reanim; 2006 Jun-Jul;53(6):378-82
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  • [Title] [Anesthesia in 2 cases of resection of a renal tumor involving the vena cava].
  • [Transliterated title] Anestesia en dos casos de resección de un tumor renal con extensión a la vena cava.
  • Renal tumors can be associated with a thrombus that affects the renal vein and even the inferior vena cava.
  • Radical surgery may require a 2-phase approach involving different anesthetic techniques: an abdominal approach for removal of the kidney and a thoracic approach for extraction of the thrombus, with extracorporeal circulation and in some cases cessation of blood circulation.
  • The thrombus was in the renal vein and the inferior vena cava, extending to the outlet to the right atrium in both cases.
  • [MeSH-major] Anesthesia, Inhalation / methods. Carcinoma, Renal Cell / surgery. Hypothermia, Induced. Kidney Neoplasms / surgery. Nephrectomy / methods. Renal Veins / surgery. Thrombectomy / methods. Thrombosis / surgery. Vena Cava, Inferior / surgery. Wilms Tumor / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Blood Loss, Surgical. Combined Modality Therapy. Dactinomycin / administration & dosage. Doxorubicin / administration & dosage. Extracorporeal Circulation. Fatal Outcome. Female. Hemostatic Techniques. Humans. Male. Middle Aged. Multiple Organ Failure / etiology. Neoplasm Invasiveness. Postoperative Hemorrhage / drug therapy. Pulmonary Embolism / etiology. Vincristine / administration & dosage

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  • (PMID = 16910146.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin
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16. Zhuge Y, Cheung MC, Yang R, Perez EA, Koniaris LG, Sola JE: Pediatric non-Wilms renal tumors: subtypes, survival, and prognostic indicators. J Surg Res; 2010 Oct;163(2):257-63
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  • [Title] Pediatric non-Wilms renal tumors: subtypes, survival, and prognostic indicators.
  • BACKGROUND: To determine the outcomes and predictors of survival for pediatric non-Wilms renal tumors (NWRT).
  • The major histologic groups included renal cell carcinoma (RCC) (44%), clear cell sarcoma of the kidney (CCSK) (17%), and malignant rhabdoid tumor (MRT) (12%).
  • [MeSH-major] Carcinoma, Renal Cell / mortality. Kidney Neoplasms / mortality. Rhabdoid Tumor / mortality. Sarcoma, Clear Cell / mortality
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Multivariate Analysis. Prognosis. SEER Program

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20538287.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Auber F, Jeanpierre C, Denamur E, Jaubert F, Schleiermacher G, Patte C, Cabrol S, Leverger G, Nihoul-Fékété C, Sarnacki S: Management of Wilms tumors in Drash and Frasier syndromes. Pediatr Blood Cancer; 2009 Jan;52(1):55-9
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  • [Title] Management of Wilms tumors in Drash and Frasier syndromes.
  • BACKGROUND: Children with WT1 gene-related disorders such as Denys-Drash syndrome (DDS) and Frasier syndrome (FS) are at increased risk of Wilms tumor and end-stage renal disease.
  • We investigated whether Wilms tumors in these patients displayed a specific phenotype or behavior and whether nephron-sparing surgery was beneficial.
  • Wilms tumors occurred in 15 patients, being unilateral in 10 and bilateral in 5 (20 tumors).
  • Median age at Wilms tumor diagnosis was 9 months.
  • According to the International Society of Pediatric Oncology Working Classification, there were 19 intermediate-risk tumors and one high-risk tumor; no tumor was anaplastic.
  • In patients with nephropathy who underwent unilateral nephrectomy for Wilms tumor or nephron-sparing surgery for bilateral Wilms tumor, mean time to dialysis was 11 or 9 months, respectively.
  • Other tumors included three gonadoblastomas (in two patients), one retroperitoneal soft-tissue tumor, and one transitional cell papilloma of the bladder.
  • Two patients, both with stage I Wilms tumor, died from end-stage renal disease-related complications.
  • CONCLUSION: Most Wilms tumors in children with WT1-related disorders were early-stage and intermediate-risk tumors, with a young age at diagnosis.
  • In patients without end-stage renal disease, nephron-sparing surgery should be considered for delaying the onset of renal failure.
  • [MeSH-major] Denys-Drash Syndrome / therapy. Frasier Syndrome / therapy. Wilms Tumor / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease Management. Humans. Kidney Failure, Chronic / prevention & control. Nephrectomy. Retrospective Studies. Young Adult

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  • (PMID = 18816692.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Su MC, Huang WC, Lien HC: Beta-catenin expression and mutation in adult and pediatric Wilms' tumors. APMIS; 2008 Sep;116(9):771-8
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  • [Title] Beta-catenin expression and mutation in adult and pediatric Wilms' tumors.
  • Wilms' tumor is the most common pediatric renal neoplasm, but its occurrence in adults is very rare.
  • In contrast to pediatric Wilms' tumor (PWT), very little is known about the pathogenesis of adult Wilms' tumor (AWT).
  • To investigate the role of dysregulation of the Wnt pathway in AWT, tumor samples from 4 AWTs and 19 PWTs were surveyed for subcellular localization of beta-catenin by immunohistochemistry and potential mutation of the beta-catenin gene by sequencing.
  • [MeSH-major] Kidney Neoplasms / genetics. Kidney Neoplasms / metabolism. Mutation. Wilms Tumor / genetics. Wilms Tumor / metabolism. beta Catenin / genetics. beta Catenin / metabolism
  • [MeSH-minor] Adult. Base Sequence. Cell Nucleus / metabolism. Child, Preschool. DNA, Neoplasm / genetics. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retrospective Studies. Signal Transduction. Wnt Proteins / metabolism. Young Adult

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  • (PMID = 19024596.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / DNA, Neoplasm; 0 / Wnt Proteins; 0 / beta Catenin
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19. Lazarus J, Moolman C: Renal cell carcinoma as second malignancy in patient with previous Wilms tumor. Urology; 2009 Sep;74(3):598-600
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  • [Title] Renal cell carcinoma as second malignancy in patient with previous Wilms tumor.
  • Adult survivors of childhood Wilms tumor are at an increased risk of a second malignancy.
  • Renal cell carcinoma is not thought to be an associated late malignancy.
  • We present a case report of an adult survivor of Wilms tumor who was treated for renal cell carcinoma.
  • Our findings highlight the need for renal surveillance and to consider nephron-sparing surgery in future Wilms tumor treatment protocols.
  • [MeSH-major] Carcinoma, Renal Cell. Kidney Neoplasms / therapy. Neoplasms, Second Primary. Wilms Tumor / therapy

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  • (PMID = 19523667.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Zirn B, Wittmann S, Gessler M: Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy. Am J Kidney Dis; 2005 Jun;45(6):1100-4
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  • [Title] Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy.
  • Wilms tumor gene 1 (WT1) is essential for normal urogenital development.
  • Mutations in WT1 are involved in Wilms tumorigenesis and several associated syndromes, such as Denys-Drash, Frasier, or Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome.
  • The index patient is a 22-year-old woman in whom Wilms tumor and ureter duplex were diagnosed at the age of 9 years and who subsequently developed slow progressive nephropathy.
  • Her mother also had late-onset nephropathy that led to end-stage renal failure, whereas renal function in 1 brother of the index patient was not impaired.
  • We hypothesize that this type of mutation (read-through), which leads to an elongated, but otherwise unchanged, WT1 protein, may be associated with incomplete penetrance and a relatively late onset of both Wilms tumor and nephropathy in this family.
  • [MeSH-major] Genes, Wilms Tumor. Glomerulonephritis / complications. Kidney Neoplasms / genetics. Nephritis, Interstitial / complications. Wilms Tumor / genetics
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Child. DNA Mutational Analysis. DNA, Neoplasm / genetics. Disease Progression. Exons / genetics. Female. Germ-Line Mutation. Humans. Kidney Failure, Chronic / etiology. Kidney Pelvis / abnormalities. Male. Pedigree. Penetrance. Point Mutation. Ureter / abnormalities. WT1 Proteins / chemistry. WT1 Proteins / genetics

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  • (PMID = 15957141.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / WT1 Proteins
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21. Kraushaar G, Wiebe S: Renal cell carcinoma as a second malignant neoplasm in a patient with non-syndromic hemihypertrophy and previous Wilms tumor. Pediatr Radiol; 2005 Dec;35(12):1208-11
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  • [Title] Renal cell carcinoma as a second malignant neoplasm in a patient with non-syndromic hemihypertrophy and previous Wilms tumor.
  • Survivors of childhood Wilms tumors are at an increased risk of second malignant neoplasms.
  • Recently, it has been postulated that renal cell carcinoma is among the malignancies for which this population is at risk.
  • We present the unique case of an adult Wilms tumor survivor with non-syndromic hemihypertrophy (NSHH) who developed renal cell carcinoma.
  • This case highlights the need for close follow-up in two populations: adults who have survived Wilms tumor and those with NSHH.
  • [MeSH-major] Carcinoma, Renal Cell. Kidney Neoplasms. Neoplasms, Second Primary. Wilms Tumor
  • [MeSH-minor] Adult. Female. Humans. Hypertrophy / surgery. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 16010526.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Parambil JG, Aughenbaugh GL, Pereira TC, Gillespie DJ, Ryu JH: Solitary pulmonary metastasis presenting 20 years after primary resection of Wilms tumor. Mayo Clin Proc; 2005 Nov;80(11):1514-6
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  • [Title] Solitary pulmonary metastasis presenting 20 years after primary resection of Wilms tumor.
  • Wilms tumor is the most common renal malignancy of childhood.
  • We describe a 22-year-old man who presented with hemoptysis and a solitary pulmonary lesion 20 years after primary resection of Wilms tumor.
  • Surgical resection revealed a solitary pulmonary metastasis from Wilms tumor.
  • This case shows that late relapse in the form of a solitary pulmonary mass can occur in patients with Wilms tumor.
  • [MeSH-major] Kidney Neoplasms / pathology. Lung Neoplasms / secondary. Wilms Tumor / secondary
  • [MeSH-minor] Adult. Humans. Male. Time Factors

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  • (PMID = 16295032.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Piotrowski Z, Canter DJ, Kutikov A, Al-Saleem T, Pei J, Testa JR, Uzzo RG: Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms' tumor variant. Can J Urol; 2010 Aug;17(4):5309-12
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  • [Title] Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms' tumor variant.
  • PURPOSE: A case of the rare, benign, Wilms' tumor (WT) variant, metanephric adenofibroma (MAF), is presented.
  • MATERIALS AND METHODS: The patient is a 21-year-old female with an incidentally discovered enhancing renal mass.
  • RESULTS: The 19 cm renal mass was ultimately resected via robot-assisted partial nephrectomy.
  • Pathologic diagnosis at our institution was confirmed as a MAF by the National Wilms' Tumor Study Group (NWTSG).
  • CONCLUSION: Difficult to differentiate from WT, it is imperative that MAF be recognized and appropriately diagnosed because unlike adult WT, the natural history of MAF is indolent and adjuvant chemo/radiation therapy is rarely necessary.
  • [MeSH-major] Adenofibroma / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods. Robotics. Wilms Tumor / surgery
  • [MeSH-minor] Female. Humans. Young Adult

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  • (PMID = 20735912.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
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24. Hsiao HL, Chang TH, Wu WJ, Huang CH: Adult Wilms' tumor with hypospadias and cryptorchidism: a case report. Kaohsiung J Med Sci; 2007 Nov;23(11):584-9
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  • [Title] Adult Wilms' tumor with hypospadias and cryptorchidism: a case report.
  • Abdominal ultrasonography and imaging studies showed a left renal mass.
  • Radical nephrectomy was performed on the patient and the pathology report revealed Wilms' tumor (nephroblastoma).
  • The patient underwent chemotherapy after surgery and no tumor recurrence was noted after 8 months of regular follow-up.
  • [MeSH-major] Cryptorchidism / complications. Hypospadias / complications. Kidney Neoplasms / complications. Wilms Tumor / complications

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  • (PMID = 18055308.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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25. Morrison AA, Viney RL, Saleem MA, Ladomery MR: New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes. Am J Physiol Renal Physiol; 2008 Jul;295(1):F12-7
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  • [Title] New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.
  • The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads.
  • In the adult kidney, WT1 expression is limited to the glomerular podocytes.
  • These include WAGR (for Wilms tumor, aniridia, genitourinary anomalies, and mental retardation), and Frasier and Denys-Drash syndromes.
  • [MeSH-major] Genes, Wilms Tumor / physiology. Podocytes / physiology. WT1 Proteins / physiology

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  • (PMID = 18385267.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human; 0 / RNA, Messenger; 0 / WT1 Proteins; 9007-49-2 / DNA
  • [Number-of-references] 80
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26. Yau T, Leong CH, Chan WK, Chan JK, Liang RH, Epstein RJ: A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO). Cancer Chemother Pharmacol; 2008 Apr;61(4):717-20
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  • [Title] A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO).
  • Here we report an unusual case of mixed Wilms' tumour and angiosarcoma in a 38-year-old female patient who presented with haematuria and right lower back pain.
  • A computed tomographic (CT) scan confirmed a massive renal tumour associated with extensive retroperitoneal lymph node involvement, bony metastases and a right hip fracture.
  • Histopathology revealed differentiated adult Wilms' tumour with renal angiosarcoma, whereas the pathology of the para-aortic lymph node and bone metastasis revealed angiosarcoma only.
  • This case suggests that highly angiogenic tumours such as angiosarcoma may be effectively palliated using agents usually reserved for refractory Wilms' tumour, and supports the view that adult Wilms' tumour is more sensitive to such agents.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hemangiosarcoma / drug therapy. Kidney Neoplasms / drug therapy. Wilms Tumor / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Carboplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasm Recurrence, Local. Platelet Count. Tomography, X-Ray Computed. Vincristine / administration & dosage

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  • (PMID = 17571263.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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27. Geethamani V, Kusuma V, Gowda KM, Saini ML: Adult Wilms' tumour: a case report with review of literature. Diagn Pathol; 2006;1:46

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  • [Title] Adult Wilms' tumour: a case report with review of literature.
  • BACKGROUND: Wilms' tumor is the commonest primary malignant renal tumor in childhood.
  • Rarely, it may present in the adult age group.
  • Abdominal ultrasound revealed a right renal mass measuring 11 x 10 cms, and a clinical diagnosis of renal cell carcinoma was made.
  • Nephrectomy was performed, and a final diagnosis of adult Wilms' tumor was made based on the criteria proposed by Kilton et al.
  • CONCLUSION: The possibility of an adult Wilms' tumor should be considered when a patient presents with pain in the flank and a renal mass.
  • Rarity of the tumor favors documentation in literature.

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  • [Cites] J Clin Oncol. 2004 Nov 15;22(22):4500-6 [15542800.001]
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  • (PMID = 17144931.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1702367
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28. Wadhwa N, Mishra K, Agarwal S: Wilms' tumour in adults: a report of three cases. Indian J Pathol Microbiol; 2005 Apr;48(2):235-8
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  • [Title] Wilms' tumour in adults: a report of three cases.
  • Wilms' tumour is the most common pediatric renal neoplasm.
  • We report 3 cases of Wilms' tumour in adults, their clinico-pathological profile and review the literature including the cases reported from India.
  • All cases were stage II (National Wilms' Tumour Study), favourable histology.
  • Although Wilms' tumour in adults is morphologically similar to its childhood counterpart, it often responds poorly to the combination chemotherapy.
  • [MeSH-major] Kidney Neoplasms / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Female. Humans. Male

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  • (PMID = 16758679.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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29. Brown SD, Vansonnenberg E, Morrison PR, Diller L, Shamberger RC: CT-guided radiofrequency ablation of pediatric Wilms tumor in a solitary kidney. Pediatr Radiol; 2005 Sep;35(9):923-8
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  • [Title] CT-guided radiofrequency ablation of pediatric Wilms tumor in a solitary kidney.
  • We describe the treatment of Wilms tumor in a solitary kidney in a 5-year-old girl using percutaneous CT-guided RFA.
  • Although it might only be useful ultimately as a temporizing measure, oncologists and surgeons might wish to consider RFA in children who would otherwise require dialysis and renal transplantation or who are poor surgical candidates.
  • Various specific technical issues differentiate pediatric from adult tumor ablation, including the amount of intra-abdominal fat, need for smaller grounding pads, and potential systemic effects of tissue heating.
  • [MeSH-major] Catheter Ablation. Kidney Neoplasms / surgery. Radiography, Interventional. Tomography, X-Ray Computed. Wilms Tumor / surgery

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  • (PMID = 15928925.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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30. Stefanowicz J, Kosiak M, Kosiak W, Korbus-Kosiak A, Sierota D, Owczuk R: Cystatin C and parenchymal thickness/kidney length ratio in Wilms tumor survivors. Pediatr Blood Cancer; 2010 Jan;54(1):41-6
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  • [Title] Cystatin C and parenchymal thickness/kidney length ratio in Wilms tumor survivors.
  • BACKGROUND: This study presents a clinical, biochemical, and sonographic evaluation of single kidneys in Wilms tumor survivors.
  • PROCEDURE: The function of single kidneys in 26 Wilms tumor survivors (mean age, 11.17 years; mean follow-up, 7.09 years) was evaluated using cystatin C (CysC) levels and compared to serum creatinine concentration and glomerular filtration rate (eGFR), the latter of which was estimated by the Schwartz formula.
  • The length of the kidney, the resistance index (RI) of the renal vessels, and the parenchymal thickness/kidney length ratio (PT/KL) were evaluated by sonographic examination.
  • No differences were observed between the groups in creatinine concentration, age, follow-up evaluation, age at the time of diagnosis, or kidney size.
  • Kidney hypertrophy was observed in 23 children and was correlated with CysC (group A, R = 0.46; group B, R = 0.4; P < 0.05).
  • Hypertrophy of a single kidney increases with deteriorating kidney function.
  • PT/KL should be verified in future studies as a sonographic marker of kidney impairment.
  • [MeSH-major] Cystatin C / blood. Kidney Neoplasms / blood. Wilms Tumor / blood
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Creatinine / blood. Female. Glomerular Filtration Rate. Humans. Kidney Function Tests. Male. Survival Rate. Survivors. Young Adult

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19774637.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CST3 protein, human; 0 / Cystatin C; AYI8EX34EU / Creatinine
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31. Khayyata S, Grignon DJ, Aulicino MR, Al-Abbadi MA: Metanephric adenoma vs. Wilms' tumor: a report of 2 cases with diagnosis by fine needle aspiration and cytologic comparisons. Acta Cytol; 2007 May-Jun;51(3):464-7
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  • [Title] Metanephric adenoma vs. Wilms' tumor: a report of 2 cases with diagnosis by fine needle aspiration and cytologic comparisons.
  • BACKGROUND: Metanephric adenoma (MA) is a rare benign renal neoplasm that can occur at any age, whereas, Wilms' tumor (WT) is the most common malignant renal neoplasm in children and is occasionally seen in adults.
  • CASES: In case 1, a 26-year-old male had a left renal mass.
  • The cytologic differential diagnosis included Wilms' tumor, neuroectodermal tumor and metanephric adenoma.
  • Nephrectomy revealed Wilms' tumor.
  • In case 2, a 24-year-old female presented with erythrocytosis and a right renal mass.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Wilms Tumor / diagnosis. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Cell Nucleolus / pathology. Cell Nucleus Shape. Diagnosis, Differential. Female. Humans. Kidney / pathology. Kidney / surgery. Male. Nephrectomy


32. Geenen MM, Bakker PJ, Kremer LC, Kastelein JJ, van Leeuwen FE: Increased prevalence of risk factors for cardiovascular disease in long-term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy. Pediatr Blood Cancer; 2010 Oct;55(4):690-7
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  • [Title] Increased prevalence of risk factors for cardiovascular disease in long-term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy.
  • We determined the prevalence of CRFs in long-term survivors of acute lymphoblastic leukemia (ALL) and Wilms tumor.
  • PROCEDURE: Adult survivors of ALL and Wilms tumor treated with radiotherapy and chemotherapy (RT + CT) or treated with chemotherapy alone (CT) were compared with sibling controls.
  • CRFs (hypertension, diabetes mellitus, hypercholesterolemia, obesity, renal insufficiency) and hormonal deficiencies were assessed in each participant.
  • RESULTS: Seventy-nine ALL, 62 Wilms tumor survivors, and 69 control subjects (mean ages 24.5, 25.9, and 26 years, respectively) were enrolled.
  • In the Wilms RT + CT group significantly more survivors had hypertension (21.6% vs. 1.4%, P < 0.001) and renal insufficiency (8.1% vs. 0%, P = 0.016) compared to controls.
  • There were also more patients with multiple CRFs in the Wilms RT + CT group (16.2% vs. 2.9% in controls, P = 0.019).
  • Hypogonadism was seen in 18.9% of survivors in the Wilms RT + CT group.
  • CONCLUSIONS: Long-term survivors of ALL and Wilms tumor have unfavorable CRFs due to previous RT not CT.
  • [MeSH-major] Cardiovascular Diseases / etiology. Kidney Neoplasms / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Wilms Tumor / complications
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Humans. Infant. Infant, Newborn. Lipids / blood. Prevalence. Risk Factors. Survivors

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  • [Copyright] Copyright 2010 Wiley-Liss, Inc.
  • (PMID = 20589650.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipids
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33. Ellison DA, Parham DM, Bridge J, Beckwith JB: Immunohistochemistry of primary malignant neuroepithelial tumors of the kidney: a potential source of confusion? A study of 30 cases from the National Wilms Tumor Study Pathology Center. Hum Pathol; 2007 Feb;38(2):205-11
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  • [Title] Immunohistochemistry of primary malignant neuroepithelial tumors of the kidney: a potential source of confusion? A study of 30 cases from the National Wilms Tumor Study Pathology Center.
  • Ewing sarcoma/peripheral primitive neuroectodermal tumor (pPNET) is a rare primary tumor of the kidney with morphologic features similar to those of other primitive tumors.
  • Previous studies have shown that these tumors frequently stain positively with immunostains against CD99 and FLI-1 and negatively with stains against WT-1, suggesting that these markers may be used for the distinction between Wilms tumor and pPNET.
  • We present 30 cases of primary malignant neuroepithelial tumor with immunohistochemical profiles and reverse transcriptase polymerase chain reaction (RT-PCR) analysis and show that immunophenotypic overlap exists between Wilms tumor and pPNET.
  • A subset of 30 neuroepithelial tumors from the National Wilms Tumor Study originally categorized as putative pPNETs of the kidney was stained with FLI-1, WT-1, and thyroid transcription factor-1.
  • Reliance upon immunohistochemistry as the sole means of ancillary diagnosis in renal pPNET can lead to confusing results.
  • We recommend molecular fusion studies for clarification of primitive renal tumors with unexpected immunophenotypic results.
  • [MeSH-major] Immunohistochemistry / methods. Kidney Neoplasms / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology
  • [MeSH-minor] Adult. Child. Diagnosis, Differential. Humans. In Situ Hybridization, Fluorescence. Microfilament Proteins / analysis. Microfilament Proteins / genetics. Nuclear Proteins / analysis. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. RNA-Binding Protein EWS. Receptors, Cytoplasmic and Nuclear / analysis. Receptors, Cytoplasmic and Nuclear / genetics. Reproducibility of Results. Transcription Factors / analysis. WT1 Proteins / analysis. WT1 Proteins / genetics. Wilms Tumor / genetics. Wilms Tumor / metabolism. Wilms Tumor / pathology

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  • (PMID = 17134738.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / FLII protein, human; 0 / Microfilament Proteins; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Transcription Factors; 0 / WT1 Proteins; 0 / thyroid nuclear factor 1
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34. Gallagher DJ, Duffy A, McCaffrey J: Wilms' tumour in adults: a case report and review of the literature. Ir J Med Sci; 2007 Mar;176(1):49-51
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  • [Title] Wilms' tumour in adults: a case report and review of the literature.
  • BACKGROUND: Wilms' tumour is a very rare adult malignancy representing 1% of adult renal tumours.
  • It is however the most common renal tumour of childhood, and adult patients are treated in accordance with paediatric protocols.
  • AIM: To review modern day management of adult Wilms' tumour.
  • METHODS: We report a case of adult Wilms' tumour and discuss the management including the use of newer treatment modalities.
  • CONCLUSION: In the absence of randomised controlled data, central reporting of cases of adult Wilms' Tumour may help improve management.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Wilms Tumor / diagnosis
  • [MeSH-minor] Adult. Carboplatin / therapeutic use. Cyclophosphamide / therapeutic use. Etoposide / therapeutic use. Humans. Male. Nephrectomy. Positron-Emission Tomography

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  • (PMID = 17849525.001).
  • [ISSN] 0021-1265
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
  • [Number-of-references] 7
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35. Blish KR, Clausen KA, Hawkins GA, Garvin AJ, Willingham MC, Turner JC, Torti FM, Torti SV: Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors. J Exp Clin Cancer Res; 2010 Nov 16;29:147
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  • [Title] Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors.
  • BACKGROUND: Deletions within the short arm of chromosome 7 are observed in approximately 25% of adult and 10% of Wilms pediatric renal tumors.
  • Within Wilms tumors, the region of interest has been delineated to a 2-Mb minimal region that includes ten known genes.
  • Two of these ten candidate genes, SOSTDC1 and MEOX2, are particularly relevant to tumor development and maintenance.
  • This finding, coupled with evidence that SOSTDC1 is frequently downregulated in adult renal cancer and regulates both Wingless-Int (Wnt)- and bone morphogenetic protein (BMP)-induced signaling, points to a role for SOSTDC1 as a potential tumor suppressor.
  • METHODS: To investigate this hypothesis, we interrogated the Oncomine database to examine the SOSTDC1 levels in adult renal clear cell tumors and pediatric Wilms tumors.
  • We then performed single nucleotide polymorphism (SNP) and sequencing analyses of SOSTDC1 in 25 pediatric and 36 adult renal tumors.
  • RESULTS: Within the Oncomine database, we found that SOSTDC1 levels were reduced in adult renal clear cell tumors and pediatric Wilms tumors.
  • Through SNP and sequencing analyses of 25 Wilms tumors, we identified four with loss of heterozygosity (LOH) at 7p and three that affected SOSTDC1.
  • Of 36 adult renal cancers, we found five with LOH at 7p, two of which affected SOSTDC1.
  • CONCLUSIONS: This study shows that genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors.
  • Although our conclusions are limited by sample size, we suggest that an alternative mechanism such as epigenetic silencing of SOSTDC1 may be a key contributor to the reduced SOSTDC1 mRNA and protein levels observed in renal cancer.

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  • (PMID = 21080955.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA079448; United States / NCI NIH HHS / CA / R21CA119181; United States / NCI NIH HHS / CA / T32CA079448
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proteins; 0 / SOSTDC1 protein, human; 0 / Wnt Proteins
  • [Other-IDs] NLM/ PMC3002326
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36. Yakoushina TV, Morotti RA, Strauchen JA, Unger PD: Renal benign epithelial nodal inclusions. Ann Diagn Pathol; 2008 Jun;12(3):181-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal benign epithelial nodal inclusions.
  • The majority of these inclusions were observed in perinephric lymph nodes removed during nephrectomies from pediatric patients with Wilms' tumors.
  • We report 2 cases of benign renal tubular epithelial inclusions located in the perinephric hilar lymph nodes.
  • One of our cases is, to our knowledge, the first case of benign renal epithelial inclusions reported in an adult patient.
  • [MeSH-major] Epithelial Cells / pathology. Inclusion Bodies / pathology. Kidney Diseases / pathology. Kidney Tubules / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Biomarkers / metabolism. Child, Preschool. Female. Humans. Hydronephrosis / pathology. Immunohistochemistry. Kidney Neoplasms / pathology. Male. Nephrectomy. Pyelonephritis / pathology. Retrospective Studies. Wilms Tumor / pathology

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  • (PMID = 18486893.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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37. Di Renzo F, Doneda L, Menegola E, Sardella M, De Vecchi G, Collini P, Spreafico F, Fossati-Bellani F, Giavini E, Radice P, Perotti D: The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors. J Pediatr Hematol Oncol; 2006 Dec;28(12):791-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors.
  • We have previously suggested the transcription factor gene POU6F2 as a novel tumor suppressor involved in Wilms tumor (WT) predisposition.
  • Since WT arises from pluripotent embryonic renal precursors, in this study we analyzed the expression of the murine homolog Pou6f2 during kidney embryogenesis and compared it to that of Wt1, the homolog of WT1, a known WT related gene involved in mesenchyme to epithelium conversion.
  • Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) performed for Pou6f2 on kidney specimens from embryos, pups, and adult mice, showed that the Pou6f2 mRNA was more abundant in the earliest analyzed phase of kidney organogenesis (E13) than in more advanced fetal stages and in adult animal.
  • In situ RT-PCR demonstrated that Pou6f2 expression parallels the centripetal differentiation of renal morphogenesis.
  • In addition, in E18 kidney, most structures exhibiting Pou6f2 expression stained positively in immunohistochemistry for the Wt1 protein.
  • Finally, quantitative real-time RT-PCR revealed an overexpression (>/=80 times) of POU6F2 compared with normal kidney in 5 of 22 (23%) WTs.
  • The finding of a highly regulated temporal and spatial Pou6f2 expression during renal organogenesis, of its coexpression with Wt1 and of POU6F2 overexpression in a subset of WTs are consistent with a role of POU6F2 in kidney development and provide further support to its involvement in WT.
  • [MeSH-major] Gene Expression Regulation, Developmental. Gene Expression Regulation, Neoplastic. Kidney / embryology. POU Domain Factors / biosynthesis. WT1 Proteins / biosynthesis. Wilms Tumor / metabolism
  • [MeSH-minor] Adult. Aged. Animals. Cell Differentiation / genetics. Female. Genetic Predisposition to Disease. Humans. Male. Mesoderm / metabolism. Mesoderm / pathology. Mice. Neoplastic Stem Cells / metabolism. Neoplastic Stem Cells / pathology. Organogenesis / genetics

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  • (PMID = 17164647.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / POU Domain Factors; 0 / POU6F2 protein, human; 0 / WT1 Proteins
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38. Hancock AL, Brown KW, Moorwood K, Moon H, Holmgren C, Mardikar SH, Dallosso AR, Klenova E, Loukinov D, Ohlsson R, Lobanenkov VV, Malik K: A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. Hum Mol Genet; 2007 Feb 01;16(3):343-54
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  • [Title] A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis.
  • We have shown previously that AWT1 and WT1-AS are functionally imprinted in human kidney.
  • In the adult kidney, expression of both transcripts is restricted to the paternal allele, with the silent maternal allele retaining methylation at the WT1 antisense regulatory region (WT1 ARR).
  • We also report assessment of WT1 ARR methylation in developmental and tumour tissues, including the first analysis of Wilms' tumour precursor lesions, nephrogenic rests.
  • Nephrogenic rests show increases in methylation levels relative to foetal kidney and reductions relative to the adult kidney, together with biallelic expression of AWT1 and WT1-AS.
  • Our data suggest that failure of methylation spreading at the WT1 ARR early in renal development, followed by imprint erasure, occurs during Wilms' tumourigenesis.
  • We propose a model wherein imprinting defects at chromosome 11p13 may contribute to Wilms' tumourigenesis.
  • [MeSH-major] DNA-Binding Proteins / metabolism. Epigenesis, Genetic. Genes, Wilms Tumor. Genomic Imprinting. Kidney Neoplasms / genetics. Repressor Proteins / metabolism. Silencer Elements, Transcriptional / physiology. Wilms Tumor / genetics
  • [MeSH-minor] Cells, Cultured. DNA Methylation. Gene Expression Regulation, Developmental. Humans. Kidney / embryology. Kidney / metabolism. Models, Biological. Protein Isoforms / genetics. Protein Isoforms / metabolism

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  • (PMID = 17210670.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0401088
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CCCTC-binding factor; 0 / DNA-Binding Proteins; 0 / Protein Isoforms; 0 / Repressor Proteins
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39. Portugal R, Barroca H: Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour. Cytopathology; 2008 Apr;19(2):80-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour.
  • Wilms' Tumour (WT) is the most common kidney tumour in childhood, this fact and the embryonic complexity of WT create, whenever one of its three classical components predominates in cytologic smears, difficulties in the differential diagnoses with other less common entities.
  • In the present study, we review the cytological and immunohistochemical characteristics of three children renal tumours, a Clear Cell Sarcoma of the Kidney (CCSK-case1), a Cellular Mesoblastic Nephroma (CMN-case2) and a Metanephric Adenoma (MA-case3) and compare them, for differential diagnostic purposes, with smears of blastematous, mesenchymal and epithelial predominant WTs, previously diagnosed in our Department.
  • Summing up, these three cases demonstrate that cytopathologists should be aware of the occurrence of uncommon renal neoplasms in childhood and should be acquainted with their characteristics, in order to avoid false diagnoses.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology. Sarcoma, Clear Cell / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Biopsy, Fine-Needle. Child. Child, Preschool. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Inclusion Bodies / chemistry. Inclusion Bodies / pathology. Infant, Newborn. Male. Pregnancy

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  • (PMID = 17681013.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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40. Stewénius Y, Jin Y, Ora I, Panagopoulos I, Möller E, Mertens F, Sandstedt B, Alumets J, Akerman M, Merks JH, de Kraker J, Gisselsson D: High-resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic difficulties among small round cell kidney tumors. Genes Chromosomes Cancer; 2008 Oct;47(10):845-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic difficulties among small round cell kidney tumors.
  • In Wilms tumor (WT, nephroblastoma) no fusions genes or recurrent balanced translocations have been described thus far.
  • To screen for cryptic balanced translocations, we have analyzed 17 renal neoplasms, histopathologically classified as WT, by a combination of G-banding, multicolor FISH, and subtelomeric FISH.
  • As EWSR1 rearrangements are known to be a characteristic of Ewing tumors (ET), our findings illustrate the diagnostic problems regarding small cell kidney tumors and strongly argue for the need of adjuvant diagnostic techniques in this group of neoplasms.
  • [MeSH-major] Chromosome Aberrations. Kidney Neoplasms / genetics. Translocation, Genetic. Wilms Tumor / genetics
  • [MeSH-minor] Adult. Child. Child, Preschool. Chromosome Banding. Chromosomes, Human / genetics. Diagnosis, Differential. Humans. In Situ Hybridization, Fluorescence. Infant. Karyotyping. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA-Binding Protein EWS. Reverse Transcriptase Polymerase Chain Reaction. Telomere / genetics. Transcription Factors / genetics. Tumor Cells, Cultured. Ubiquitin-Protein Ligases / genetics

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  • (PMID = 18615675.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EWS-ERG fusion protein, human; 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / RNA-Binding Protein EWS; 0 / Transcription Factors; EC 6.3.2.19 / HACE1 protein, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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41. Shet T, Viswanathan S: The cytological diagnosis of paediatric renal tumours. J Clin Pathol; 2009 Nov;62(11):961-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The cytological diagnosis of paediatric renal tumours.
  • Fine needle aspiration cytology (FNAC) is used for preoperative diagnosis of paediatric renal tumours, especially in centres where preoperative chemotherapy is advocated in Wilms' tumour.
  • This review focuses on salient cytological features in specific paediatric renal tumours, the approach to resolving a differential diagnosis and the role of ancillary methods in diagnosis of paediatric renal tumours.
  • Crucial differential diagnoses include distinguishing: Wilms' tumour from benign tumours in the kidney like multicystic nephroma or congenital mesoblastic nephroma; aggressive non-Wilms' tumours of kidney like rhabdoid tumour of kidney; and Wilms' tumour from other paediatric round cell sarcomas like neuroblastoma, non-Hodgkin lymphoma etc.
  • An approach based on classifying smears according to their cellular patterns as triphasic, round cell, spindle cell or epithelioid cell type assists in classifying paediatric renal tumours on cytology.
  • Immunocytochemistry for WT1, cytokeratin, synaptophysin, leucocyte common antigen and MIC2 will aid in evaluating round cell tumours in the renal region, while WT1, bcl2, vimentin and desmin will be useful for spindle cell tumours in that region.
  • Used judiciously, FNAC is as effective a tool as a core biopsy for preoperative diagnosis of paediatric renal tumours, and with experience a 92% accuracy rate can be achieved.
  • [MeSH-major] Kidney Neoplasms / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adolescent. Age Distribution. Biopsy, Fine-Needle / methods. Carcinoma, Renal Cell / pathology. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Infant, Newborn. Nephroma, Mesoblastic / pathology. Rhabdoid Tumor / pathology. Sarcoma, Clear Cell / pathology. Sarcoma, Ewing / pathology. Young Adult

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  • (PMID = 19700411.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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42. Schedl A: Renal abnormalities and their developmental origin. Nat Rev Genet; 2007 Oct;8(10):791-802
MedlinePlus Health Information. consumer health - Kidney Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal abnormalities and their developmental origin.
  • Congenital abnormalities of the kidney and urinary tract (CAKUT) occur in 1 out of 500 newborns, and constitute approximately 20-30% of all anomalies identified in the prenatal period.
  • CAKUT has a major role in renal failure, and there is increasing evidence that certain abnormalities predispose to the development of hypertension and cardiovascular disease in adult life.
  • Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children.
  • To understand the basis of human renal diseases, it is essential to consider how the kidney develops.
  • [MeSH-major] Kidney / abnormalities. Kidney / embryology. Kidney Diseases / congenital
  • [MeSH-minor] Body Patterning. Gene Expression Regulation, Developmental. Humans. Intercellular Signaling Peptides and Proteins / metabolism. Models, Biological. Nephrons / growth & development. Signal Transduction. Stem Cells / metabolism. Ureter / abnormalities. Ureter / anatomy & histology. Ureter / growth & development. Wilms Tumor / metabolism. Wnt Proteins / metabolism

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  • (PMID = 17878895.001).
  • [ISSN] 1471-0064
  • [Journal-full-title] Nature reviews. Genetics
  • [ISO-abbreviation] Nat. Rev. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Wnt Proteins
  • [Number-of-references] 113
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43. Metsuyanim S, Pode-Shakked N, Schmidt-Ott KM, Keshet G, Rechavi G, Blumental D, Dekel B: Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Stem Cells; 2008 Jul;26(7):1808-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes.
  • Their elevation in our previous human kidney microarray screen led us examine whether they participate in processes involving normal and malignant renal progenitors.
  • We therefore analyzed the expression of the PcG genes (EZH2, BMI-1, EED, SUZ12) in relation to that of the nephric-progenitor genes (WT1, PAX2, SALL1, SIX2, CITED1) using real-time polymerase chain reaction and methylation assays during renal development, regeneration, and tumorigenesis.
  • Although all of the nephric-progenitor genes were shown to be developmentally regulated, analysis of polycomb gene expression during murine nephrogenesis and in an in vitro induction model of the nephrogenic mesenchyme indicated dynamic regulation only for EZH2 in the normal renal progenitor population.
  • In contrast, induction of adult kidney regeneration by ischemia/reperfusion injury resulted primarily in rapid elevation of BMI-1, whereas EZH2 was silenced.
  • Analysis of renal tumorigenesis in stem cell-like tumor xenografts established by serial passage of Wilms' tumor (WT) in immunodeficient mice showed cooperative upregulation of all PcG genes.
  • Accordingly, methylation-specific quantitative polymerase chain reaction demonstrated promoter hypomethylation of WT1, PAX2, and SIX2 in primary WT and fetal kidneys, whereas progressive WT xenografts showed hypermethylation of SIX2, possibly leading to loss of renal differentiation.
  • PcG genes vary in expression during renal development, regeneration, and tumorigenesis.
  • We suggest a link between polycomb activation and epigenetic alterations of the renal progenitor population in initiation and progression of renal cancer.
  • [MeSH-major] Epigenesis, Genetic. Gene Expression Regulation. Kidney / cytology. Stem Cells / cytology
  • [MeSH-minor] Adult. Animals. DNA Methylation. Disease Progression. Humans. Mesoderm / metabolism. Mice. Mice, SCID. Neoplasm Transplantation. Rats. Wilms Tumor / genetics

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  • (PMID = 18467665.001).
  • [ISSN] 1549-4918
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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44. Su J, Li SJ, Chen ZH, Zeng CH, Zhou H, Li LS, Liu ZH: Evaluation of podocyte lesion in patients with diabetic nephropathy: Wilms' tumor-1 protein used as a podocyte marker. Diabetes Res Clin Pract; 2010 Feb;87(2):167-75
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  • [Title] Evaluation of podocyte lesion in patients with diabetic nephropathy: Wilms' tumor-1 protein used as a podocyte marker.
  • Forty patients were enrolled with type 2 diabetes and proven to have DN by renal biopsy analysis.
  • [MeSH-minor] Adult. Albuminuria / metabolism. Albuminuria / pathology. Biomarkers / metabolism. Biopsy. Blood Glucose / metabolism. Cell Count. Creatinine / blood. Cytoplasm / metabolism. Cytoplasm / pathology. Diabetes Mellitus, Type 2 / complications. Diabetes Mellitus, Type 2 / metabolism. Diabetes Mellitus, Type 2 / pathology. Hemoglobin A, Glycosylated / metabolism. Humans. Kidney Glomerulus / metabolism. Kidney Glomerulus / pathology. Middle Aged. Proteinuria / metabolism. Proteinuria / pathology. WT1 Proteins / genetics. WT1 Proteins / metabolism

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  • [Copyright] 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19969384.001).
  • [ISSN] 1872-8227
  • [Journal-full-title] Diabetes research and clinical practice
  • [ISO-abbreviation] Diabetes Res. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Blood Glucose; 0 / Hemoglobin A, Glycosylated; 0 / Nuclear Proteins; 0 / WT1 Proteins; 0 / WTAP protein, human; AYI8EX34EU / Creatinine
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45. Negoro H, Kawakita M, Koda Y: Renal artery pseudoaneurysm after laparoscopic partial nephrectomy for renal cell carcinoma in a solitary kidney. Int J Urol; 2005 Jul;12(7):683-5
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  • [Title] Renal artery pseudoaneurysm after laparoscopic partial nephrectomy for renal cell carcinoma in a solitary kidney.
  • Renal artery pseudoaneurysms are a well-documented complication following trauma or percutaneous urological procedures, but are rare after partial nephrectomy.
  • We present the case of a 34-year-old woman who, after undergoing a left nephrectomy in childhood due to Wilms' tumor, had a pseudoaneurysm in a solitary kidney after laparoscopic right partial nephrectomy with extraperitoneal approach for a renal cell carcinoma.
  • The segmental renal artery feeding the pseudoaneurysm was embolized with coils without significant loss of residual renal function.
  • [MeSH-major] Aneurysm, False / etiology. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / surgery. Laparoscopy. Nephrectomy / adverse effects. Renal Artery
  • [MeSH-minor] Adult. Female. Humans. Wilms Tumor / surgery

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  • (PMID = 16045563.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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46. Grabowski J, Silberstein J, Saltzstein SL, Saenz N: Renal tumors in the second decade of life: results from the California Cancer Registry. J Pediatr Surg; 2009 Jun;44(6):1148-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal tumors in the second decade of life: results from the California Cancer Registry.
  • BACKGROUND: Renal tumors are rare in adolescents and young adults.
  • The aim of this study was to characterize the histologic condition, epidemiology, and survival of renal tumors in patients aged 11 to 20 years old using a large, population-based database.
  • All renal tumors in patients aged 11 to 20 years old were identified.
  • The data were analyzed with relation to patient age, sex and ethnicity, tumor histologic examination, and actuarial mortality rates.
  • RESULTS: Seventy-seven primary renal malignancies were identified.
  • Thirty-nine (51%) were renal cell carcinoma, 23 (30%) were Wilms' tumor, and 15 (20%) were other tumor types.
  • The mean age of the patients with renal cell carcinoma was 16.7 years old, which was significantly older than the Wilms' tumor patients (13.9 years; P < .01).
  • The 5-year cumulative survival rate of patients with renal cell carcinoma was 54%, which was worse than that of Wilms' tumor patients (77%).
  • CONCLUSION: Primary renal malignancies are uncommon in the second decade of life.
  • The most common tumor type in this age-group is renal cell carcinoma followed by Wilms' tumor.
  • Patients with renal cell carcinoma tend to be older and have a lower survival than patients with other kidney tumors.
  • [MeSH-major] Carcinoma, Renal Cell / epidemiology. Kidney Neoplasms / epidemiology. Registries. Wilms Tumor / epidemiology
  • [MeSH-minor] Adolescent. California / epidemiology. Female. Humans. Male. Survival Analysis. Young Adult

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  • (PMID = 19524731.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 2 R25 CA65745; United States / NCI NIH HHS / CA / CA8564; United States / NIMHD NIH HHS / MD / P60MD00220; United States / NCI NIH HHS / CA / U56 CA92079; United States / NCI NIH HHS / CA / U56 CA92081
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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47. Hora M, Hes O, Michal M, Boudová L, Chudácek Z, Kreuzberg B, Klecka J: Extensively cystic renal neoplasms in adults (Bosniak classification II or III)--possible "common" histological diagnoses: multilocular cystic renal cell carcinoma, cystic nephroma, and mixed epithelial and stromal tumor of the kidney. Int Urol Nephrol; 2005;37(4):743-50
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  • [Title] Extensively cystic renal neoplasms in adults (Bosniak classification II or III)--possible "common" histological diagnoses: multilocular cystic renal cell carcinoma, cystic nephroma, and mixed epithelial and stromal tumor of the kidney.
  • OBJECTIVE(S): To give an algorithm for resolution of extensively cystic renal neoplasms, preoperatively classified in the Bosniak classification as a category II and III.
  • METHODS: From 1991 to 6/2004, 701 patients with 727 renal tumours were surgically treated at our hospital.
  • RESULTS: Seven multilocular cystic renal cell carcinomas, three mixed epithelial and stromal tumour of the kidney and one cystic nephroma were diagnosed on histology.
  • CONCLUSION(S): Extensively cystic renal tumours classified as the Bosniak type II or III correspond histologically to the entities mentioned above (multilocular cystic renal cell carcinoma, cystic nephroma, mixed epithelial and stromal tumour of the kidney).
  • In such cases, the nephron sparing surgery is indicated, whenever technically feasible, as almost all extensively cystic renal tumours have a good prognosis.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Nephrectomy. Retrospective Studies. Wilms Tumor / pathology

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  • (PMID = 16362592.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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48. Radhika S, Bakshi A, Rajwanshi A, Nijhawan R, Das A, Kakkar N, Joshi K, Marwaha RK, Rao KL: Cytopathology of uncommon malignant renal neoplasms in the pediatric age group. Diagn Cytopathol; 2005 May;32(5):281-6
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  • [Title] Cytopathology of uncommon malignant renal neoplasms in the pediatric age group.
  • Malignant renal neoplasms are common solid tumors in pediatric oncology practice.
  • These include the common Wilms' tumor/nephroblastoma and the uncommon neoplasms such as clear-cell sarcoma of the kidney (CCSK), rhabdoid tumor, renal-cell carcinoma, and others.
  • The aim of this study was to describe in detail the cytopathological features of the histopathologically proven uncommon pediatric renal tumors.
  • Aspirates from Wilms' tumor, which are mesenchyme predominant, show clusters of spindle cells associated with the matrix material.
  • Renal-cell carcinoma of childhood shows similar cytological features as its adult counterpart.
  • Rhabdoid tumor of the kidney is characterized by a monomorphic population of cells with abundant cytoplasm, eccentric nuclei with prominent nucleoli.
  • Intrarenal yolk sac tumor is a rare neoplasm and shows severely pleomorphic cells on aspiration.
  • Further, non-Wilms' renal malignant neoplasms must be distinguished from the common Wilms' tumor so that appropriate chemotherapy protocols may be instituted in cases where the tumor is in an advanced stage of malignancy.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Renal Cell / pathology. Endodermal Sinus Tumor / pathology. Kidney Neoplasms / pathology. Rhabdoid Tumor / pathology. Sarcoma, Clear Cell / pathology
  • [MeSH-minor] Adolescent. Cell Nucleus / pathology. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Staining and Labeling. Wilms Tumor / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15830360.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Locali RF, Matsuoka PK, Cherbo T, Gabriel EA, Buffolo E: Renal and adrenal tumors with cardiac invasion: immediate surgical results in 14 patients. Arq Bras Cardiol; 2009 Mar;92(3):168-76
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  • [Title] Renal and adrenal tumors with cardiac invasion: immediate surgical results in 14 patients.
  • BACKGROUND: The resection of tumor thrombus of the inferior vena cava (IVC) and right atrium (RA) increases the survival rate of patients with renal/adrenal cancer.
  • OBJECTIVE: To evaluate the surgical procedure in cases of IVC and RA in the treatment of renal and adrenal tumors.
  • METHODS: Fourteen patients undergoing surgical intervention (during the period) between January 1997 and June 2007, for resection of IVC and/or RA thrombus due to renal or adrenal tumors, were retrospectively evaluated.
  • The patients (64.2% male) presented with Wilms' tumor, clear cell carcinoma and adrenal adenocarcinoma, and had mean age of 4.5, 60.5 and 2.5 years, respectively.
  • RESULTS: Suprahepatic IVC tumor thrombus were observed in all the patients, and in 62.4% of them the thrombus invaded the RA.
  • The duration of orotracheal intubation and length of hospital stay were different, according to the tumor type.
  • CONCLUSION: IVC and RA tumor thrombi are more frequent in patients with Wilms' tumor.
  • More postoperative complications are seen in patients with adrenal adenocarcinoma, and the postoperative prognosis is better for patients with Wilms' tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Heart Neoplasms / surgery. Kidney Neoplasms / pathology. Thrombectomy / methods. Vena Cava, Inferior. Venous Thrombosis / surgery
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Child. Child, Preschool. Circulatory Arrest, Deep Hypothermia Induced / methods. Extracorporeal Circulation / methods. Female. Heart Atria / surgery. Humans. Infant. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Time Factors. Wilms Tumor / pathology. Wilms Tumor / surgery. Young Adult

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  • (PMID = 19390703.001).
  • [ISSN] 1678-4170
  • [Journal-full-title] Arquivos brasileiros de cardiologia
  • [ISO-abbreviation] Arq. Bras. Cardiol.
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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50. Linam LE, Yu X, Calvo-Garcia MA, Rubio EI, Crombleholme TM, Bove K, Kline-Fath BM: Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature. Fetal Diagn Ther; 2010;28(2):100-8
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  • [Title] Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature.
  • Enlargement of a kidney on prenatal imaging is usually due to hydronephrosis or cystic renal disease, and much less often results from solid tumors such as mesoblastic nephroma, Wilms' tumor, nephroblastomatosis, renal sarcoma, and angiomyolipoma.
  • Magnetic resonance imaging is useful not only in confirming the presence of a renal mass, but also in the evaluation of the contralateral kidney for subtle abnormalities.
  • We present one case each of Wilms' tumor and mesoblastic nephroma, both detected on antenatal ultrasound and further studied with fetal magnetic resonance imaging.
  • [MeSH-major] Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology. Prenatal Diagnosis / methods. Wilms Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Pregnancy

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20587988.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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51. Shimakage M, Kawahara K, Harada S, Sasagawa T, Shinka T, Oka T: Expression of Epstein-Barr virus in renal cell carcinoma. Oncol Rep; 2007 Jul;18(1):41-6
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  • [Title] Expression of Epstein-Barr virus in renal cell carcinoma.
  • There have been few studies regarding the etiology of renal cell carcinoma.
  • To examine the possible involvement of Epstein-Barr virus (EBV) in this disease, 9 renal cell carcinoma (RCC), 2 nephroblastoma (Wilms' tumor) and 2 RCC cell lines were subjected to mRNA in situ hybridization and indirect immunofluorescence staining.
  • EBV infected all the RCC and nephroblastoma irrespective of the histological or clinical stage.
  • These results suggest that the expression of EBV may be involved in the pathogenesis of RCC and nephroblastoma.
  • [MeSH-major] Carcinoma, Papillary / virology. Carcinoma, Renal Cell / virology. Epstein-Barr Virus Infections / virology. Kidney Neoplasms / virology. Urinary Bladder Neoplasms / virology. Wilms Tumor / virology
  • [MeSH-minor] Adult. Aged. Child, Preschool. Epstein-Barr Virus Nuclear Antigens / genetics. Epstein-Barr Virus Nuclear Antigens / metabolism. Female. Fluorescent Antibody Technique. Fluorescent Antibody Technique, Indirect. Herpesvirus 4, Human / isolation & purification. Humans. In Situ Hybridization. Infant. Male. Middle Aged. Polymerase Chain Reaction. RNA Probes. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Viral / analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17549343.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Epstein-Barr Virus Nuclear Antigens; 0 / RNA Probes; 0 / RNA, Messenger; 0 / RNA, Viral
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52. Bonsib SM, Pei Y: The non-neoplastic kidney in tumor nephrectomy specimens: what can it show and what is important? Adv Anat Pathol; 2010 Jul;17(4):235-50
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  • [Title] The non-neoplastic kidney in tumor nephrectomy specimens: what can it show and what is important?
  • In the presence of a normal contralateral kidney, such as in a renal transplant donor or child with Wilms tumor, it is a benign procedure without deleterious consequences on the remaining kidney.
  • However, many adults and some children postnephrectomy will develop chronic kidney disease.
  • The non-neoplastic kidney in tumor resections may harbor a large number of developmental and acquired diseases predictive of this outcome or that convey other medically significant information.
  • Examination of the non-neoplastic kidney is a fertile opportunity to identify these unsuspected conditions that may ultimately dictate the subsequent clinical course and influence the medical care provided.
  • [MeSH-major] Kidney / pathology. Kidney Diseases / etiology. Kidney Neoplasms / surgery. Nephrectomy / adverse effects
  • [MeSH-minor] Adult. Arteriosclerosis / complications. Child. Chronic Disease. Diabetes Complications / complications. Diabetes Complications / pathology. Humans. Kidney Diseases, Cystic / etiology. Kidney Diseases, Cystic / pathology. Lymphangiogenesis. Nephrosclerosis / etiology. Nephrosclerosis / pathology. Wilms Tumor / pathology. Wilms Tumor / surgery

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  • [CommentIn] Adv Anat Pathol. 2011 Mar;18(2):173; author reply 174 [21326015.001]
  • (PMID = 20574169.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 134
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53. Shiroyanagi Y, Suzuki M, Matsuno D, Mochizuki K, Kitagawa N, Tanaka M, Tanaka Y, Yamazaki Y: Asymmetric development of tumor-like cysts in a child with autosomal dominant polycystic kidney disease. J Pediatr Surg; 2008 Nov;43(11):e21-3
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  • [Title] Asymmetric development of tumor-like cysts in a child with autosomal dominant polycystic kidney disease.
  • We report a case of asymmetric development of tumor-like cysts in a child with autosomal dominant polycystic kidney disease (ADPKD).
  • The preliminary considerations were renal cell carcinoma and Wilms' tumor.
  • After open biopsy, the patient was diagnosed with ADPKD with atypical renal cyst development.
  • The development pattern of renal cysts in children with ADPKD is varied, and open biopsy is sometimes needed.
  • [MeSH-major] Polycystic Kidney, Autosomal Dominant / diagnosis
  • [MeSH-minor] Adult. Arachnoid Cysts / complications. Biopsy. Carcinoma, Renal Cell / radiography. Child. Diagnosis, Differential. Frozen Sections. Hematuria / etiology. Humans. Kidney Neoplasms / radiography. Male. Wilms Tumor / radiography

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  • (PMID = 18970915.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Rehman J, Chughtai B, Guru K, Khan SA, Adler HL, Miller F: Wilm's tumor during pregnancy: report of laparoscopic removal and review of literature. Can J Urol; 2008 Aug;15(4):4180-3
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  • [Title] Wilm's tumor during pregnancy: report of laparoscopic removal and review of literature.
  • Wilm's tumor, or nephroblastoma, is a common renal tumor among children.
  • Few cases of Wilm's tumor have been reported in women during pregnancy.
  • The authors present a rare case of a pregnant female, who underwent laparoscopic excision of a large Wilm's tumor.
  • [MeSH-major] Kidney Neoplasms / surgery. Laparoscopy / methods. Nephrectomy / methods. Pregnancy Complications, Neoplastic. Wilms Tumor / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Pregnancy Outcome. Tomography, X-Ray Computed


55. Tabibi A, Parvin M, Abdi H, Bashtar R, Zamani N, Abadpour B: Correlation between size of renal cell carcinoma and its grade, stage, and histological subtype. Urol J; 2007;4(1):10-3
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  • [Title] Correlation between size of renal cell carcinoma and its grade, stage, and histological subtype.
  • INTRODUCTION: The aim of this study was to determine the correlation between histological subtype, size, grade, and stage of the kidney tumors and to investigate whether a correlation exists between the size of the kidney tumor and its behavior.
  • MATERIALS AND METHODS: Between 1996 and 2004, we had 212 patients with radical or partial nephrectomy due to a kidney tumor at Shaheed Labbafinejad Medical Center.
  • Their pathologic blocks were re-evaluated with consideration of their tumor size and pathologic features.
  • RESULTS: Of 212 pathologic blocks, 17 (8%) were benign and 195 (92%) were malignant masses including 179 renal cell carcinoma (RCC) tumors.
  • There was no significant relation between the size of tumor and the histological subtype.
  • Significant relations between the size of the kidney tumor and the nuclear grade (P=.007), clinical symptoms (P=.02), and extracapsular extension (P<.001) were observed.
  • CONCLUSION: Tumor size is not an independent predictor for the histological subtype of the tumors; however, larger malignant tumors may have higher grades, higher stages, and clinical symptoms.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Tumor Burden
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / surgery. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Staging. Nephrectomy. Sarcoma / pathology. Sarcoma / surgery. Wilms Tumor / pathology. Wilms Tumor / surgery

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  • (PMID = 17514604.001).
  • [ISSN] 1735-1308
  • [Journal-full-title] Urology journal
  • [ISO-abbreviation] Urol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
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56. Körner M, Waser B, Reubi JC: Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas. Int J Cancer; 2005 Jul 10;115(5):734-41
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  • [Title] Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas.
  • Numerous peptide receptors are overexpressed in human cancer, permitting in vivo tumor targeting.
  • Since NPY can play a role in the kidney, NPY receptor expression and/or endogenous production of peptides of the NPY family (NPY, PYY, PP) were evaluated in 40 renal cell carcinomas (RCCs) and 18 nephroblastomas.
  • In selected cases, NPY was observed in nerve fibers in close association with intratumoral blood vessels and in the vicinity of tumor cells, while no PYY or PP was detected immunohistochemically in these sites.
  • NPY receptors on renal tumor cells and tumor blood vessels may therefore be the molecular targets of endogenous NPY released by intratumoral nerve fibers.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Gene Expression Profiling. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology. Receptors, Neuropeptide Y / biosynthesis. Wilms Tumor / genetics. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Nerve Fibers / chemistry

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15704095.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Neuropeptide Y
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57. Sinescu I, Manu MA, Hârza M, Serbãnescu B, Stefan B, Cerempei V, Tacu D, Kerezsy E, Bucşa C, Domnişor L, Daia D, Constantinescu I: Renal transplantation--substitution therapy in advanced stage uremia. J Med Life; 2008 Apr-Jun;1(2):108-17
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  • [Title] Renal transplantation--substitution therapy in advanced stage uremia.
  • Advanced stage chronic renal failure (CRF) uremia represents one of the most severe metabolic "catastrophes" of the organism.
  • The current therapeutic possibilities consist in: hemodialysis, peritoneal dialysis and renal transplantation.
  • This paper presents the experience of the Urological Surgery, Dialysis and Renal Transplantation Center of the "Fundcni" Clinical Institute in renal transplantation, the single complete morphological and functional therapeutic option in CRF.
  • During the last 10 years, renal transplantations with kidneys from brain dead donors (multiorgan harvesting) to an adult (1997), a child (1999), a diabetic recipient (1998) and an unephric child due to bilateral Wilms' tumor (2005) were performed at "Fundeni" Renal Transplantation Center as a national première.
  • A number of 870 renal transplantations with 82% functionality rate of the grati at 10 years were performed and reported.
  • Owing to obtained results (60% of all transplanted and functional orgmans in Romania on December 2007) and to its achieved performances, the Fundeni Center represents a reference point on the European map of renal transplant.
  • [MeSH-major] Graft Rejection / drug therapy. Immunosuppressive Agents / therapeutic use. Kidney Failure, Chronic / surgery. Kidney Transplantation. Uremia / surgery

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  • [Cites] Am J Kidney Dis. 1995 Aug;26(2):387-98 [7645548.001]
  • (PMID = 20108457.001).
  • [ISSN] 1844-122X
  • [Journal-full-title] Journal of medicine and life
  • [ISO-abbreviation] J Med Life
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  • [Number-of-references] 20
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58. Imam JS, Buddavarapu K, Lee-Chang JS, Ganapathy S, Camosy C, Chen Y, Rao MK: MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. Oncogene; 2010 Sep 2;29(35):4971-9
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  • [Title] MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers.
  • In this study, we investigate the mechanism by which the Six1 homeobox protein, which has a crucial role during development, is frequently deregulated in several poor outcome, aggressive, metastatic adult human cancers, including breast cancer, ovarian cancer, hepatocellular carcinoma and pediatric malignancies such as rhabdomyosarcoma and Wilms' tumor.
  • Analyses of ovarian cancers, pediatric renal tumors and multiple breast cancer cell lines showed decreased miR-185 expression, paralleling an increase in Six1 levels.
  • Further investigation revealed that miR-185 impedes anchorage-independent growth and cell migration, in addition to suppressing tumor growth in vivo, implicating it to be a potent tumor suppressor.
  • Our results indicate that miR-185 mediates its tumor suppressor function by regulating cell-cycle proteins and Six1 transcriptional targets c-myc and cyclin A1.
  • Furthermore, we show that miR-185 sensitizes Six1-overexpressing resistant cancer cells to apoptosis in general and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in particular.
  • Together, our findings suggest that the altered expression of the novel tumor suppressor miR-185 may be one of the central events that leads to dysregulation of oncogenic protein Six1 in human cancers.
  • [MeSH-minor] 3' Untranslated Regions / genetics. Adult. Animals. Apoptosis / genetics. Cell Cycle / genetics. Cell Line, Tumor. Cell Proliferation. Gene Expression Regulation, Neoplastic / genetics. Humans. Male. Mice. TNF-Related Apoptosis-Inducing Ligand / metabolism

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  • (PMID = 20603620.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / Homeodomain Proteins; 0 / MIRN185 microRNA, human; 0 / MicroRNAs; 0 / SIX1 protein, human; 0 / TNF-Related Apoptosis-Inducing Ligand
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59. Sessa A, Esposito A, Giliberti A, Bergallo M, Costa C, Rossano R, Lettieri E, Capuano M: BKV reactivation in renal transplant recipients: diagnostic and therapeutic strategy--case reports. Transplant Proc; 2008 Jul-Aug;40(6):2055-8
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  • [Title] BKV reactivation in renal transplant recipients: diagnostic and therapeutic strategy--case reports.
  • In renal transplant recipients, BKV replication may cause tubulointerstitial nephropathy (BKVAN) with increasing prevalence rates--1% in 1995, 8% in 2007--leading to the loss of the transplanted organ in 30% to 80% of cases.
  • With the availability of diagnostic programs (decoy cells in urine, amplification of viral DNA by polymerase chain reaction (PCR) on serum and urine, real time (RT)-PCR test for mRNA VP1 urine (mRNA-VP1), and renal biopsy accompanied by reduction in immunosuppression, administration of leflunomide, cidofovir (after hydration), and N-acetylcysteine, as well as immunoglobulin by intravenous injection (IVIg), the incidence of renal loss caused by BKVAN infection has been reduced by 10% to 80%.
  • Early diagnosis and therapeutic intervention (cidofovir + IVIg) led to reduction in the viral load, with improvement and stabilization in renal function.
  • Considering the high positive predictive value (98%) of mRNA VP1, it should be possible to avoid renal biopsy.
  • [MeSH-major] Antiviral Agents / therapeutic use. BK Virus / isolation & purification. Kidney Transplantation / adverse effects. Polyomavirus Infections / diagnosis. Tumor Virus Infections / diagnosis
  • [MeSH-minor] Adult. Creatinine / blood. Female. Glomerular Filtration Rate. Humans. Kidney Diseases / complications. Kidney Diseases / surgery. Kidney Failure, Chronic / etiology. Kidney Failure, Chronic / surgery. Kidney Neoplasms / surgery. Male. Middle Aged. Reoperation. Treatment Outcome. Viral Load. Virus Activation. Wilms Tumor / surgery

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  • (PMID = 18675128.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; AYI8EX34EU / Creatinine
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60. Löwik MM, van den Berkmortel FW, Noordam C, van Hamersvelt HW, van den Heuvel LP, Levtchenko EN: [A genetic childhood disease with consequences in adult life: the Denys-Drash syndrome]. Ned Tijdschr Geneeskd; 2005 Jul 30;149(31):1751-5
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  • [Title] [A genetic childhood disease with consequences in adult life: the Denys-Drash syndrome].
  • In a 17-year-old woman with absent sexual development and a congenital nephrotic syndrome leading to renal failure, the Denys-Drash syndrome was diagnosed after development of an ovarian dysgerminoma.
  • The Denys-Drash syndrome is characterised by the triad: progressive nephropathy due to diffuse mesangial sclerosis, male pseudo-hermaphroditism (XY karyotype with ambiguous or female genital organs) and an increased risk of developing Wilms' tumour and gonadoblastoma.
  • The syndrome is generally caused by a genetic defect in the Wilms' tumour suppressor 1 gene (WT1 gene).
  • The WT1 gene encodes a transcription factor playing an important role in renal and genital development.
  • [MeSH-major] Denys-Drash Syndrome / genetics. Disorders of Sex Development / genetics. Genes, Wilms Tumor. Ovarian Neoplasms / genetics. Urogenital Abnormalities / genetics

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  • [ErratumIn] Ned Tijdschr Geneeskd. 2005 Oct 1;149(40):2260
  • (PMID = 16114294.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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61. Dekel B, Metsuyanim S, Schmidt-Ott KM, Fridman E, Jacob-Hirsch J, Simon A, Pinthus J, Mor Y, Barasch J, Amariglio N, Reisner Y, Kaminski N, Rechavi G: Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney. Cancer Res; 2006 Jun 15;66(12):6040-9
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  • [Title] Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney.
  • Wilms' tumor (WT), the embryonic kidney malignancy, is suggested to evolve from a progenitor cell population of uninduced metanephric blastema, which typically gives rise to nephrons.
  • However, apart from blastema, WT specimens frequently contain cells that have differentiated into renal tubular or stromal phenotypes, complicating their analysis.
  • We aimed to define tumor-progenitor genes that function in normal kidney development using WT xenografts (WISH-WT), in which the blastema accumulates with serial passages at the expense of differentiated cells.
  • Herein, we did transcriptional profiling using oligonucleotide microarrays of WISH-WT, WT source, human fetal and adult kidneys, and primary and metastatic renal cell carcinoma.
  • Interestingly, ischemic/reperfusion injury to adult mouse kidneys reinduced the expression of PEG3, PEG10, DLK1, and MEIS1, hence simulating embryogenesis.
  • Thus, multiple imprinted and stemness genes that function to expand the renal progenitor cell population may lead to evolution and maintenance of WT.
  • [MeSH-major] Genomic Imprinting. Kidney Neoplasms / genetics. Wilms Tumor / genetics
  • [MeSH-minor] Animals. Gene Expression Profiling. Homeodomain Proteins / biosynthesis. Homeodomain Proteins / genetics. Humans. Kidney / embryology. Kidney / growth & development. Mice. Mice, Inbred BALB C. Mice, Nude. Mice, SCID. Multigene Family. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. Neoplasm Transplantation. Neoplastic Stem Cells. Oligonucleotide Array Sequence Analysis. Rats. Transplantation, Heterologous

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  • (PMID = 16778176.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 0 / myeloid ecotropic viral integration site 1 protein
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62. Singam P, Ho C, Hong GE, Mohd A, Tamil AM, Cheok LB, Zainuddin Z: Clinical characteristics of renal cancer in Malaysia : a ten year review. Asian Pac J Cancer Prev; 2010;11(2):503-6
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  • [Title] Clinical characteristics of renal cancer in Malaysia : a ten year review.
  • Renal cancer is rare and its incidence is 1.9 per 100,000 in the Malaysian population, which consists of three major ethnic groups (Malay, Chinese and Indians).
  • The study included all renal cancer patients from a single medical institution over ten years, with a total of 75 cases.
  • Tumour histology were clear cell (72%), urothelial cell (13.3%), sarcomatoid cell and nephroblastoma each contributed 2.7%.
  • In conclusion we observed significant influences of age and race in the clinical presentation of renal cancer in our institution based population.
  • [MeSH-major] Carcinoma, Papillary / therapy. Carcinoma, Renal Cell / therapy. Carcinoma, Squamous Cell / therapy. Kidney Neoplasms / therapy. Wilms Tumor / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Female. Humans. Incidence. Malaysia. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Risk Factors. Survival Rate. Time Factors. Young Adult

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  • (PMID = 20843141.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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63. Silberstein J, Grabowski J, Saltzstein SL, Kane CJ: Renal cell carcinoma in the pediatric population: Results from the California Cancer Registry. Pediatr Blood Cancer; 2009 Feb;52(2):237-41
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  • [Title] Renal cell carcinoma in the pediatric population: Results from the California Cancer Registry.
  • BACKGROUND: Renal cell carcinoma (RCC) is a rare disease in children and adolescents.
  • RESULTS: From 1988 to 2004, 43 cases of RCC were identified in patients younger than 21 years, accounting for 4.3% of all renal tumors in this age group.
  • The overall annual age-adjusted incidence was 0.01/100,000 with the tumor more common in non-Hispanic blacks (0.03/100,000) compared to non-Hispanic whites (0.01/100,000), Hispanics (<0.01/100,000), and non-Hispanic Asians/Pacific Islanders (<0.01/100,000).
  • CONCLUSION: Pediatric RCC is an uncommon and aggressive tumor that occurs most frequently in children in the second decade of life, more often in females and blacks.
  • The epidemiological characteristics of this tumor differ from adult RCC and Wilms tumor, suggesting its distinctive biology and potential need for alternative treatment strategies.
  • [MeSH-major] Carcinoma, Renal Cell / epidemiology
  • [MeSH-minor] Adolescent. Age Distribution. California / epidemiology. Child. Child, Preschool. Ethnic Groups. Female. Humans. Incidence. Infant. Infant, Newborn. Male. Neoplasm Staging. Registries. Sex Factors. Survival Analysis. Young Adult

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18937317.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Derouiche A, Ouni A, Kourda N, Hentati H, Ben Slama MR, Chebil M: Cystic nephroma in the adult: pathological aspects and therapeutic implications. Pathologica; 2007 Dec;99(6):446-9
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  • [Title] Cystic nephroma in the adult: pathological aspects and therapeutic implications.
  • Cystic nephroma is a benign renal neoplasm.
  • The differential diagnoses of Cystic nephroma are recently described mixed epithelial and stromal tumours of the kidney and cystic renal cell carcinoma.
  • The Authors report three cases of Cystic nephroma and illustrate the clinical, radiological and histological features of this renal neoplasm.
  • [MeSH-major] Diagnostic Errors. Kidney Diseases, Cystic / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Cystadenocarcinoma / diagnosis. Echinococcosis / diagnosis. Female. Humans. Male. Middle Aged. Neoplasms, Germ Cell and Embryonal / diagnosis. Nephrectomy. Wilms Tumor / classification. Wilms Tumor / pathology

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  • (PMID = 18416340.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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65. Sambuis C, Albouy B, Riopel C, Gobet F, Grise P, Pfister C: [Multilocular cystic nephroma in an adult: diagnostic and therapeutic strategy]. Prog Urol; 2005 Apr;15(2):315-8
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  • [Title] [Multilocular cystic nephroma in an adult: diagnostic and therapeutic strategy].
  • Only histological examination can confirm the diagnosis and eliminate multilocular cystic renal carcinoma or necrotic pseudocystic carcinoma.
  • [MeSH-major] Kidney Neoplasms. Wilms Tumor

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  • (PMID = 15999616.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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66. Zhou H, Cheruvanky A, Hu X, Matsumoto T, Hiramatsu N, Cho ME, Berger A, Leelahavanichkul A, Doi K, Chawla LS, Illei GG, Kopp JB, Balow JE, Austin HA 3rd, Yuen PS, Star RA: Urinary exosomal transcription factors, a new class of biomarkers for renal disease. Kidney Int; 2008 Sep;74(5):613-21
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  • [Title] Urinary exosomal transcription factors, a new class of biomarkers for renal disease.
  • Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers.
  • To study whether they contain transcription factors, we collected urine from two acute kidney injury models (cisplatin or ischemia-reperfusion), two podocyte injury models (puromycin-treated rats or podocin-Vpr transgenic mice) and from patients with focal segmental glomerulosclerosis, acute kidney injury and matched controls.
  • Exosomes were isolated by differential centrifugation and found to contain activating transcription factor 3 (ATF3) and Wilms Tumor 1 (WT-1) proteins detected by Western blot.
  • ATF3 was found in exosomes isolated from patients with acute kidney injury but not from patients with chronic kidney disease or controls.
  • Our findings suggest that transcription factor ATF3 may provide a novel renal tubular cell biomarker for acute kidney injury while WT-1 may detect early podocyte injury.
  • [MeSH-major] Kidney Diseases / urine. Transcription Factors / urine
  • [MeSH-minor] Activating Transcription Factor 3 / urine. Acute Kidney Injury / chemically induced. Acute Kidney Injury / urine. Adult. Aged. Animals. Biomarkers / urine. Case-Control Studies. Cisplatin / toxicity. Gene Products, vpr / genetics. Glomerulosclerosis, Focal Segmental / urine. Humans. Intracellular Signaling Peptides and Proteins / genetics. Kidney / injuries. Male. Membrane Proteins / genetics. Mice. Mice, Transgenic. Middle Aged. Podocytes / drug effects. Podocytes / pathology. Podocytes / physiology. Rats. Rats, Sprague-Dawley. Reperfusion Injury / urine. WT1 Proteins / urine

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  • (PMID = 18509321.001).
  • [ISSN] 1523-1755
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DK043400-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Activating Transcription Factor 3; 0 / Biomarkers; 0 / Gene Products, vpr; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / NPHS2 protein; 0 / Transcription Factors; 0 / WT1 Proteins; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ NIHMS43564; NLM/ PMC2562924
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67. Paner GP, Turk TM, Clark JI, Lindgren V, Picken MM: Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes. Arch Pathol Lab Med; 2005 Oct;129(10):1317-21
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  • Lymph node involvement derived from a discrete neoplastic process fundamentally implies tumor malignancy.
  • We describe a 10-cm right renal metanephric adenoma incidentally discovered in a 30-year-old woman during cesarean section for a triplet pregnancy.
  • Necrosis present in this lesion appeared to be secondary to tumor physical disruption.
  • The tumor cells were positive for Wilms tumor 1 (WT1) antigen, pankeratin, and CD57, focally positive for epithelial membrane antigen, and negative for cytokeratin 7, cytokeratin 34betaE12, and CD56.
  • Electron microscopy confirmed the tumor's epithelial nature, and cytogenetics revealed a diploid 46XX karyotype.
  • The tumor proliferation index with Ki-67 was only 3% to 5% and the proliferating cell nuclear antigen index was 0%.
  • These cells were highlighted by pankeratin but were nonreactive to WT1 antigen, similar to the nonviable cells in the primary tumor.
  • We postulate that the lymph node inclusions found in this case represent passive transport of neoplastic cells to the lymph node following manipulation of the renal mass.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Lymph Nodes / pathology. Neoplasm Seeding
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Cytogenetic Analysis. Diagnosis, Differential. Female. Humans. Kidney / pathology. Neoplasm Metastasis / diagnosis. Pregnancy. Wilms Tumor / diagnosis

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  • (PMID = 16196523.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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68. Nelson MB, Meeske K: Recognizing health risks in childhood cancer survivors. J Am Acad Nurse Pract; 2005 Mar;17(3):96-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To provide information about the special health needs of childhood cancer survivors through a discussion of Wilms' tumor, a common childhood renal tumor, and case studies of two survivors of Wilms' tumor, who encountered significant health problems as adults.
  • CONCLUSIONS: Adult healthcare practitioners may help to decrease morbidity of childhood cancer survivors in adulthood when they are knowledgeable about the risks of this population.
  • IMPLICATIONS FOR PRACTICE: With well-established success in the treatment of childhood cancer, there are many young and middle-aged adult survivors of the disease.
  • Most survivors eventually discontinue follow-up with their pediatric oncologists and receive primary health care from adult providers, many of whom are unaware of survivors' health risks.
  • [MeSH-major] Aftercare / organization & administration. Antineoplastic Agents / adverse effects. Primary Health Care / organization & administration. Radiotherapy / adverse effects. Survivors. Wilms Tumor / therapy
  • [MeSH-minor] Adult. Child. Female. Health Services Needs and Demand. Humans. Kidney Diseases / etiology. Kidney Diseases / prevention & control. Los Angeles / epidemiology. Male. Morbidity. Musculoskeletal Diseases / etiology. Musculoskeletal Diseases / prevention & control. Neoplasm Staging. Neoplasms, Second Primary / etiology. Neoplasms, Second Primary / prevention & control. Nurse Practitioners / organization & administration. Nursing Assessment. Oncology Nursing / organization & administration. Patient Education as Topic. Risk Assessment

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  • (PMID = 15748222.001).
  • [ISSN] 1041-2972
  • [Journal-full-title] Journal of the American Academy of Nurse Practitioners
  • [ISO-abbreviation] J Am Acad Nurse Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 30
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69. Lerut E, Roskams T, Joniau S, Oyen R, Achten R, Van Poppel H, Debiec-Rychter M: Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics. Hum Pathol; 2006 Sep;37(9):1227-32
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  • Metanephric adenoma is a rare benign tumor of the kidney.
  • It is considered to be derived from embryonic renal tissue and to be the benign counterpart of the Wilms tumor.
  • At renal ultrasonography and magnetic resonance imaging, a hemorrhagic tumor of 10 cm in diameter originating from the right kidney was seen.
  • Based on the imaging findings, the diagnosis of a cystic renal cell carcinoma with recent hemorrhage was suggested, and a radical nephrectomy was performed.
  • The karyotype of the tumor was 46,XX,t(1;22)(q22;q13),t(15;16)(q21;p13).
  • [MeSH-major] Adenoma / genetics. Adenoma / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology. Pregnancy Complications / genetics. Pregnancy Complications / pathology
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / pathology. Chromosome Aberrations. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Kidney / embryology. Kidney / pathology. Magnetic Resonance Imaging. Nephrectomy. Pregnancy. Ultrasonography. Wilms Tumor / pathology


70. Patel NP, Geisinger KR, Zagoria RJ, Bergman S: Fine needle aspiration biopsy of metanephric adenoma: a case report. Acta Cytol; 2009 May-Jun;53(3):327-31
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  • BACKGROUND: Metanephric adenoma (MA) is a rare, benign renal neoplasm.
  • Regarding treatment, radioflrequency ablation (RFA) is an emerging alternative to surgical resection of renal neoplasms in appropriately selected patients.
  • CASE: A 49-year-old woman had a 3.3-cm cortical mass in the left kidney.
  • Although the differential diagnosis included adult Wilms' tumor and papillary renal cell carcinoma, the bland morphology and IHC staining pattern strongly favored a neoplasm consistent with MA.
  • CONCLUSION: FNAB can be used to diagnose most renal neoplasms.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, CD57 / analysis. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Catheter Ablation / methods. Diagnosis, Differential. Female. Humans. Middle Aged. Minimally Invasive Surgical Procedures. Treatment Outcome. WT1 Proteins / analysis. Wilms Tumor / diagnosis

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  • (PMID = 19534278.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / WT1 Proteins
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71. Castellino SM, Martinez-Borges AR, McLean TW: Pediatric genitourinary tumors. Curr Opin Oncol; 2009 May;21(3):278-83
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  • RECENT FINDINGS: Newly identified constitutional epigenetic defects in Wilms tumor genes extend the understanding of Wilms tumor risk in children lacking syndromic features, and add to the complexity of the pathogenesis of these tumor suppressor genes.
  • Pediatric renal cell carcinoma has distinct molecular characteristics and clinical associations from the adult counterpart.
  • [MeSH-minor] Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / genetics. Kidney Neoplasms / therapy. Male. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / genetics. Rhabdomyosarcoma / therapy. Testicular Neoplasms / diagnosis. Testicular Neoplasms / genetics. Testicular Neoplasms / therapy. Wilms Tumor / diagnosis. Wilms Tumor / genetics. Wilms Tumor / therapy

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  • (PMID = 19295433.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA122061
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
  • [Other-IDs] NLM/ NIHMS595581; NLM/ PMC4086793
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72. Cambio AJ, Evans CP, Kurzrock EA: Non-surgical management of multicystic dysplastic kidney. BJU Int; 2008 Apr;101(7):804-8
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  • [Title] Non-surgical management of multicystic dysplastic kidney.
  • OBJECTIVES: To better define the outcome and association of multicystic dysplastic kidney (MCDK) with hypertension, vesico-ureteric reflux (VUR), infection and cancer, as there is no consensus on the management of patients born with MCDK.
  • METHODS: The Medline database was searched for articles published between 1965 and 2006 and written in the English language, and containing the keywords 'multicystic dysplastic kidney'.
  • About 25% of patients will have VUR into the contralateral kidney, of which 90% is grade <or=3.
  • The overall risk of Wilms' tumour developing in a MCDK is <1 in 2000.
  • All reported Wilms' tumours were identified before 4 years of age and 70% presented as a palpable mass.
  • In theory, ultrasonographic surveillance until 4 years old might allow the earlier detection of a Wilms' tumour, and decrease the intensity of chemotherapy and improve prognosis.
  • [MeSH-major] Multicystic Dysplastic Kidney / therapy
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Renal Cell / etiology. Humans. Hypertension, Renovascular / etiology. Kidney Neoplasms / etiology. Risk Factors. Wilms Tumor / etiology

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  • (PMID = 18190645.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 36
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73. Benetti E, Caridi G, Malaventura C, Dagnino M, Leonardi E, Artifoni L, Ghiggeri GM, Tosatto SC, Murer L: A novel WT1 gene mutation in a three-generation family with progressive isolated focal segmental glomerulosclerosis. Clin J Am Soc Nephrol; 2010 Apr;5(4):698-702
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  • BACKGROUND AND OBJECTIVES: Wilms tumor-suppressor gene-1 (WT1) plays a key role in kidney development and function.
  • RESULTS: Three family members reached end-stage renal disease in full adulthood.
  • None had genital abnormalities or Wilms tumor.
  • CONCLUSIONS: The lack of Wilms tumor or other related phenotypes suggests the expansion of WT1 gene analysis in patients with focal segmental glomerulosclerosis, regardless of age or presence of typical Denys-Drash or Frasier syndrome clinical features.
  • [MeSH-major] Genes, Wilms Tumor. Glomerulosclerosis, Focal Segmental / genetics. Kidney Failure, Chronic / genetics. Mutation. WT1 Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Aged. Amino Acid Substitution. Biopsy. Computational Biology. DNA Mutational Analysis. Disease Progression. Exons. Genetic Predisposition to Disease. Humans. Italy. Male. Middle Aged. Models, Molecular. Pedigree. Phenotype. Podocytes / metabolism. Podocytes / pathology. Protein Conformation. Proteinuria / genetics. Risk Factors. Structure-Activity Relationship

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  • (PMID = 20150449.001).
  • [ISSN] 1555-905X
  • [Journal-full-title] Clinical journal of the American Society of Nephrology : CJASN
  • [ISO-abbreviation] Clin J Am Soc Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / WT1 Proteins
  • [Other-IDs] NLM/ PMC2849688
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74. Grieco V, Riccardi E, Belotti S, Scanziani E: Immunohistochemical study of porcine nephroblastoma. J Comp Pathol; 2006 Feb-Apr;134(2-3):143-51
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  • [Title] Immunohistochemical study of porcine nephroblastoma.
  • Nephroblastoma, a relatively common renal neoplasm of young swine, represents the animal counterpart of Wilms' tumour of children.
  • The kidney originates from mesenchymal blastema, which changes to epithelium, losing VIM and acquiring CK expression.
  • In the adult mammalian kidney, CK 19 is expressed only by the parietal epithelium of Bowman's capsule and the distal tubules.
  • This finding, together with the co-expression of VIM detected in some tubules, demonstrates the embryonic origin of nephroblastoma.
  • [MeSH-major] Immunoenzyme Techniques / veterinary. Kidney Neoplasms / veterinary. Swine Diseases / pathology. Wilms Tumor / veterinary
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Kidney / metabolism. Kidney / pathology. Mesoderm / metabolism. Mesoderm / pathology. Mitotic Index. Swine. Vimentin / metabolism

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  • (PMID = 16540114.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin
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75. Schumacher V, Gueler B, Looijenga LH, Becker JU, Amann K, Engers R, Dotsch J, Stoop H, Schulz W, Royer-Pokora B: Characteristics of testicular dysgenesis syndrome and decreased expression of SRY and SOX9 in Frasier syndrome. Mol Reprod Dev; 2008 Sep;75(9):1484-94
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  • Frasier syndrome (FS) is characterized by chronic renal failure in early adulthood, varying degrees of gonadal dysgenesis, and a high risk for gonadal germ cell malignancies, particularly gonadoblastoma.
  • Although it is known to arise from heterozygous splice mutations in intron 9 of the Wilms' tumor gene 1 (WT1), the mechanisms by which these mutations result in gonadal dysgenesis in humans remain obscure.
  • [MeSH-minor] Adult. Cells, Cultured. Child. DNA Mutational Analysis. Down-Regulation. Genes, Wilms Tumor. Humans. Lysine / genetics. Male. Mutation. RNA, Messenger / metabolism. SOX9 Transcription Factor. Serine / genetics. Spermatogenesis / genetics. Threonine / genetics

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  • (PMID = 18271004.001).
  • [ISSN] 1098-2795
  • [Journal-full-title] Molecular reproduction and development
  • [ISO-abbreviation] Mol. Reprod. Dev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / High Mobility Group Proteins; 0 / RNA, Messenger; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / SRY protein, human; 0 / Sex-Determining Region Y Protein; 0 / Sox9 protein, mouse; 0 / Transcription Factors; 2ZD004190S / Threonine; 452VLY9402 / Serine; K3Z4F929H6 / Lysine
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76. Nggada HA, Eni UE, Nwankwo EA: Histopathological findings in nephrectomy specimens--A review of 42 cases. Niger Postgrad Med J; 2006 Sep;13(3):244-6
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  • Nephroblastoma, the second commonest, accounted for 23.8% of all cases and is the major malignant indication for nephrectomies.
  • Renal cell carcinoma and hydronephrosis accounted for 7(16.7%) cases each; polycystic kidney, transitional cell carcinoma and non-Hodgkin's lymphoma.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Nephrectomy. Pyelonephritis / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Hydronephrosis / pathology. Male. Middle Aged. Polycystic Kidney Diseases / pathology. Retrospective Studies

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  • (PMID = 17278316.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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77. Dokmak S, Cabral C, Couvelard A, Aussilhou B, Belghiti J, Sauvanet A: Pancreatic metastasis from nephroblastoma: an unusual entity. JOP; 2009;10(4):396-9
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  • [Title] Pancreatic metastasis from nephroblastoma: an unusual entity.
  • CONTEXT: Pancreatic metastasis from renal cell carcinoma is a well-known entity.
  • A nephroblastoma is a frequent childhood cancer but can also occur in adults.
  • A metastatic nephroblastoma mainly affects the lung and the liver.
  • Pancreatic metastases from a nephroblastoma are very rare.
  • CASE REPORT: We report an extremely rare case of pancreatic metastases in a 20-year-old man who had a right nephroblastoma resected at 9 years of age and liver metastases treated by right hepatectomy at 18 years of age.
  • Pathological examination confirmed pancreatic and liver metastases from a nephroblastoma composed of blastematous cells mixed with embryonic tubular structures without lymph node metastases.
  • CONCLUSION: This is probably the first case of pancreatic metastasis from a nephroblastoma reported in a living patient.
  • A nephroblastoma, like clear cell renal carcinoma, can be considered a possible etiology of pancreatic metastasis from a primary renal tumor.
  • [MeSH-major] Kidney Neoplasms / pathology. Pancreatic Neoplasms / secondary. Wilms Tumor / pathology
  • [MeSH-minor] Combined Modality Therapy. Drug Therapy / methods. Humans. Male. Pancreaticoduodenectomy / methods. Treatment Outcome. Young Adult

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  • (PMID = 19581742.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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78. Tsukamoto Y, Namikawa T, Tatesaki R, Kotani T, Tanaka H: Expression and adhesive activity of SC1, an Ig superfamily cell adhesion molecule, in sporadic nephroblastomas of chicken. Oncol Rep; 2006 Jan;15(1):137-41
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  • Western blot analysis showed SC1 to be recognized as approximately 100 kDa and enriched in embryonic metanephros with a lower level in the adult kidney, while it was overexpressed in nephroblastomas.
  • In contrast, it had almost completely disappeared in the adult kidney; parts of the distal convoluted and intermediated tubules, collecting ducts, and Bowman's capsule slightly expressed SC1.
  • In all 32 cases of nephroblastoma, SC1 was overexpressed in most characteristic components in tumors such as neoplastic epithelia with various types of differentiation, blastemal cell condensations, and glomeruloid bodies.
  • Primary culture cells from a nephroblastoma expressed SC1 on the cell surface, whereas cells from the adult kidney showed only weak expression.
  • A cell aggregation assay revealed that the dissociated cells from a nephroblastoma have strong aggregation activity, which was inhibited by anti-SC1 antibody.
  • In contrast, the self-aggregation of adult chicken kidney cells was weaker than that of the tumor and not inhibited by the antibody.
  • These findings suggest that the expression of SC1 might play a potential role in both the structural formation of nephroblastomas, based on its adhesive activity, and normal renal development.
  • [MeSH-major] Activated-Leukocyte Cell Adhesion Molecule / metabolism. Chickens. Kidney Neoplasms / veterinary. Poultry Diseases / metabolism. Wilms Tumor / veterinary
  • [MeSH-minor] Animals. Cell Adhesion. Immunoglobulins / immunology. Immunohistochemistry. Kidney / chemistry. Kidney / metabolism. Kidney / pathology

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  • (PMID = 16328046.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Activated-Leukocyte Cell Adhesion Molecule; 0 / Immunoglobulins
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79. Wiesbauer P: [Nephrogenic tumors]. Radiologe; 2008 Oct;48(10):932-9
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  • Nephroblastomas are the most common malignant renal tumors in childhood.
  • [MeSH-major] Kidney Neoplasms. Wilms Tumor
  • [MeSH-minor] Adult. Age Factors. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Incidence. Kidney / pathology. Liver Neoplasms / secondary. Magnetic Resonance Imaging. Male. Neoplasm Staging. Practice Guidelines as Topic. Randomized Controlled Trials as Topic. Tomography, X-Ray Computed. Ultrasonography

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  • [Cites] Pediatr Radiol. 2006 Jul;36(7):714-7 [16770676.001]
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  • (PMID = 18854965.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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80. Stefanowicz J, Owczuk R, Sierota D, Kaczorowska-Hać B, Balcerska A: Does antineoplasm treatment decrease the glomerular filtration rate in children? Kidney Blood Press Res; 2009;32(3):194-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • BACKGROUND: The aim of this cross-sectional study was to test the hypothesis that children diagnosed with nephroblastoma experience increased disturbance in renal filtration even after prompt treatment compared to patients treated for other neoplastic childhood diseases.
  • PROCEDURES: Our study included 127 children and young adults, who were successfully treated for nephroblastoma (n = 34), oncohaematological childhood diseases (n = 58), and other solid tumours (n = 35).
  • RESULTS: Our studies show that patients who were successfully treated for nephroblastoma and other solid tumours have lower GFR (GFR(Sch) 118 +/- 20, p = 0.00006, and 117 +/- 22, p = 0.00003; GFR(Filler) 99 +/- 17, p = 0.0001, and 104 +/- 21 ml/min/1.73 m(2), p = 0.0002) than children treated for oncohaematological diseases (GFR(Sch) 137 +/- 19, GFR(Filler) 121 +/- 18 ml/min/1.73 m(2)).
  • CONCLUSIONS: Patients diagnosed with nephroblastoma and other solid tumours have lower eGFR than children with oncohaematological childhood diseases and are at higher risk for developing CKD.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Glomerular Filtration Rate / drug effects. Wilms Tumor / drug therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cross-Sectional Studies. Female. Hematologic Neoplasms. Humans. Kidney Function Tests. Male. Neoplasms. Remission Induction. Treatment Outcome. Young Adult

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19521109.001).
  • [ISSN] 1423-0143
  • [Journal-full-title] Kidney & blood pressure research
  • [ISO-abbreviation] Kidney Blood Press. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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81. Taskinen S, Lohi J, Kivisaari R, Fagerholm R, Rintala R, Taskinen M: Segmental cystic kidney tumours in children. Scand J Urol Nephrol; 2009;43(6):476-81
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  • [Title] Segmental cystic kidney tumours in children.
  • OBJECTIVE: Segmental cystic tumours in the kidney are extremely rare in children.
  • MATERIAL AND METHODS: The operative database from 1993 to 2008 of the Hospital for Children and Adolescents, University of Helsinki, was evaluated for segmental cystic renal tumours without any solid component.
  • All patients underwent kidney-preserving surgery with resection of the cystic tumour.
  • Two patients had neoplasias: one cystic nephroma and one cystic partially differentiated nephroblastoma.
  • Two patients had a non-neoplastic tumour; localized cystic disease of the kidney and segmental adult type autosomal dominant polycystic kidney disease.
  • CONCLUSIONS: Preoperative and perioperative diagnosis is difficult in cases of segmental cystic kidney tumours in a child.
  • [MeSH-major] Kidney / pathology. Kidney Diseases, Cystic / diagnosis. Kidney Diseases, Cystic / pathology
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Female. Humans. Incidence. Infant. Infant, Newborn. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Magnetic Resonance Imaging. Male. Polycystic Kidney, Autosomal Dominant / diagnosis. Polycystic Kidney, Autosomal Dominant / pathology. Polycystic Kidney, Autosomal Dominant / surgery. Wilms Tumor / diagnosis. Wilms Tumor / pathology. Wilms Tumor / surgery

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  • (PMID = 19968582.001).
  • [ISSN] 1651-2065
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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82. Zhou W, Boucher RC, Bollig F, Englert C, Hildebrandt F: Characterization of mesonephric development and regeneration using transgenic zebrafish. Am J Physiol Renal Physiol; 2010 Nov;299(5):F1040-7
ZFIN. ZFIN .

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  • The zebrafish is a valuable vertebrate model for kidney research.
  • The majority of previous studies focused on the zebrafish pronephros, which comprises only two nephrons and is structurally simpler than the mesonephros of adult fish and the metanephros of mammals.
  • To evaluate the zebrafish system for more complex studies of kidney development and regeneration, we investigated the development and postinjury regeneration of the mesonephros in adult zebrafish.
  • We found that mesonephrogenesis continues throughout the life of zebrafish, with a rapid growth phase during the juvenile period and a slower phase in adulthood such that the total nephron number of juvenile and adult fish linearly correlates with body mass.
  • Following gentamicin-induced renal injury, the zebrafish mesonephros can undergo de novo regeneration of mesonephric nephrons, a process known as neonephrogenesis.
  • This suggests that wt1b may serve as an early marker of fated renal progenitor cells.

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  • (PMID = 20810610.001).
  • [ISSN] 1522-1466
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK088767; United States / NIDDK NIH HHS / DK / P30-DK-079312; United States / NIDDK NIH HHS / DK / R01-DK-088767
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDH17 protein, zebrafish; 0 / Cadherins; 0 / Genetic Markers; 0 / Gentamicins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / NPHS2 protein; 0 / Protein Synthesis Inhibitors; 0 / Zebrafish Proteins; 147336-22-9 / Green Fluorescent Proteins
  • [Other-IDs] NLM/ PMC2980409
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83. Radvanský J, Slabý K, Radvanská J, Malis J, Eckschalger T, Sulc J, Safárová M, Kolský A, Procházka M, Gilík J: [Late effect of treatment of nephroblastoma in patients treated in 1980-2001 in a single centre]. Klin Onkol; 2010;23(4):245-55
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  • [Title] [Late effect of treatment of nephroblastoma in patients treated in 1980-2001 in a single centre].
  • BACKGROUNDS: The aim of the study was to describe the late effects in a cohort of patients in long-term remission (> 5 years from end of treatment) diagnosed and treated for nephroblastoma at the single paediatric centre during 1980- 2001.
  • PATIENTS AND METHODS: 151 patients were examined for renal function, lipid profile, sonography, echocardiography, exercise capacity and postural status.
  • It should include clinical examination, kidney function and blood pressure monitoring, sonographic and echocardiography examination, long-term physiotherapeutic care and prevention of cardiovascular diseases.
  • [MeSH-major] Kidney Neoplasms / therapy. Wilms Tumor / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / adverse effects. Blood Pressure. Child. Child, Preschool. Echocardiography. Female. Follow-Up Studies. Humans. Infant. Kidney / physiology. Lipids / blood. Male. Physical Fitness. Quality of Life. Remission Induction. Young Adult

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  • (PMID = 20806823.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Lipids
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84. Sigauke E, Rakheja D, Maddox DL, Hladik CL, White CL, Timmons CF, Raisanen J: Absence of expression of SMARCB1/INI1 in malignant rhabdoid tumors of the central nervous system, kidneys and soft tissue: an immunohistochemical study with implications for diagnosis. Mod Pathol; 2006 May;19(5):717-25
MedlinePlus Health Information. consumer health - Kidney Cancer.

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  • The histologic diagnosis of malignant rhabdoid tumor depends on identification of characteristic rhabdoid cells-large cells with eccentrically located nuclei and abundant, eosinophilic cytoplasm-and immunohistochemistry with antibodies to vimentin, keratin and epithelial membrane antigen.
  • We assessed SMARCB1/INI1 expression in 17 rhabdoid tumors and 57 other tumors of the CNS, kidney or soft tissue using immunohistochemistry.
  • In total, 12 brain, three renal and two soft tissue rhabdoid tumors were examined along with four glioblastomas, four pilocytic astrocytomas, four oligodendrogliomas, two ependymomas, two choroid plexus papillomas, five pituitary adenomas, four germinomas, four renal carcinomas with Xp11.2 translocations, two clear cell sarcomas, two Wilms' tumors, one renal medullary carcinoma, two desmoplastic small round cell tumors, two alveolar rhabdomyosarcomas, two embryonal rhabdomyosarcomas, one low-grade chondrosarcoma, two extraskeletal myxoid chondrosarcomas, one mesenchymal chondrosarcoma, four malignant peripheral nerve sheath tumors, five metastatic carcinomas and four epithelioid sarcomas, two primary and two metastatic.
  • The neoplastic cells of all rhabdoid tumors, the four epithelioid sarcomas and the renal medullary carcinoma did not express SMARCB1/INI1 by immunohistochemistry; neoplastic cells of all other tumors expressed SMARCB1/INI1.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. DNA-Binding Proteins / biosynthesis. Kidney Neoplasms / pathology. Rhabdoid Tumor / pathology. Soft Tissue Neoplasms / pathology. Transcription Factors / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Child. Child, Preschool. Chromosomal Proteins, Non-Histone. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Middle Aged

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  • (PMID = 16528370.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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85. Argani P, Laé M, Ballard ET, Amin M, Manivel C, Hutchinson B, Reuter VE, Ladanyi M: Translocation carcinomas of the kidney after chemotherapy in childhood. J Clin Oncol; 2006 Apr 1;24(10):1529-34
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  • [Title] Translocation carcinomas of the kidney after chemotherapy in childhood.
  • Renal cell carcinoma (RCC) occurring as a secondary malignancy is uncommon.
  • The indications for the antecedent chemotherapy were varied and included acute promyelocytic leukemia, acute myeloid leukemia with t(9;11), bilateral Wilms' tumor, systemic lupus erythematosus, and conditioning regimen of bone marrow transplant for Hurler's syndrome.
  • CONCLUSION: Cytotoxic chemotherapy may predispose to the development of renal translocation carcinomas.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Carcinoma, Renal Cell / genetics. Kidney Neoplasms / genetics. Neoplasm Proteins / genetics. Neoplasms, Second Primary / genetics. Translocation, Genetic
  • [MeSH-minor] Adolescent. Adult. Child. Humans

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  • (PMID = 16575003.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA95785
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Neoplasm Proteins; 0 / TFE3 protein, human; 0 / TFEB protein, human
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86. Lee AH: The histological diagnosis of metastases to the breast from extramammary malignancies. J Clin Pathol; 2007 Dec;60(12):1333-41
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  • Two-thirds of tumours had features raising the possibility of metastasis, such as clear cell carcinoma suggestive of renal origin and small cell carcinoma suggestive of pulmonary origin.
  • Immunohistochemical panels to distinguish mammary carcinoma (oestrogen receptor, gross cystic fluid protein-15) from common metastases to the breast, including carcinoma of the lung (thyroid transcription factor-1), malignant melanoma (S100, HMB45, melan-A) and ovarian serous papillary carcinoma (Wilms' tumour 1), are discussed.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Breast. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Female. Humans. Immunophenotyping. Kidney Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Male. Melanoma / diagnosis. Melanoma / secondary. Middle Aged. Ovarian Neoplasms / diagnosis

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  • (PMID = 18042689.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 93
  • [Other-IDs] NLM/ PMC2095576
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87. Hsiao HL, Wu WJ, Chang MY, Ke HL, Huang CH: Unusual case of multilocular cystic nephroma treated with nephron sparing technique: a case report. Kaohsiung J Med Sci; 2006 Oct;22(10):515-8
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  • This lesion is believed to be part of a spectrum of renal cystic disorders with multilocular cyst and cystic Wilms' tumor representing the two extremes and usually presents with a benign character.
  • We report a 22-year-old female who presented with a painful right renal mass and gross hematuria.
  • [MeSH-major] Kidney Diseases, Cystic / surgery. Kidney Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Nephrectomy

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  • (PMID = 17098684.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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88. Stefanowicz J, Grabiec-Wiśniewska A, Stachowicz-Stencel T, Adamkiewicz-Drozyńska E, Bień E, Kaczorowska-Hać B, Połczyńska K, Szołkiewicz A, Sierota D, Maciejka-Kapuścińska L, Płoszyńska A, Izycka-Swieszewska E, Szutowicz E, Czauderna P, Reiter M, Hennig M, Balcerska A: [Second neoplasms in children with solid tumours in the years 1992-2007. Experiences of Gdańsk medical academy]. Med Wieku Rozwoj; 2008 Oct-Dec;12(4 Pt 2):1141-7
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  • They were treated for nephroblastoma - 3 cases, soft tissue sarcoma - 2, Ewing's sarcoma - 1, medulloblastoma - 1, retinoblastoma - 1 and neuroblastoma - 1 case.
  • The second neoplasms were: acute non lymphoblastic leukaemia - 2, soft tissue sarcoma - 2, osteosarcoma - 2, chondrosarcoma - 1, renal cell carcinoma - 1 and glioblastoma multiforme - 1 case.
  • [MeSH-major] Leukemia, Myeloid, Acute / epidemiology. Neoplasms, Neuroepithelial / epidemiology. Neoplasms, Second Primary / epidemiology. Sarcoma / epidemiology. Wilms Tumor / epidemiology
  • [MeSH-minor] Adolescent. Adult. Child. Disease Progression. Female. Humans. Incidence. Male. Poland / epidemiology. Prognosis. Young Adult


89. Vujanić GM, Kelsey A, Perlman EJ, Sandstedt B, Beckwith JB: Anaplastic sarcoma of the kidney: a clinicopathologic study of 20 cases of a new entity with polyphenotypic features. Am J Surg Pathol; 2007 Oct;31(10):1459-68
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  • [Title] Anaplastic sarcoma of the kidney: a clinicopathologic study of 20 cases of a new entity with polyphenotypic features.
  • We report 20 cases of a distinct, previously unrecognized renal neoplasm, anaplastic sarcoma of the kidney with polyphenotypic features.
  • The tumors were identified by re-reviewing tumors with unusual anaplastic features from the National Wilms Tumor Study Pathology Center, the International Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group trials.
  • Twelve tumors presented in the right kidney, and 5 in the left (laterality was unknown in 3 cases).
  • The most common presentation was a renal mass.
  • The nodules of cartilage showed both benign and malignant features, often within the same tumor.
  • Cytokeratin, using the antibody CAM5.2, was uniformly negative within the tumor cells.
  • Tumor stage was known in 15 patients including 7 stage I, 4 stage II, 3 stage III, and 1 stage IV tumors.
  • They were usually diagnosed as anaplastic Wilms tumors and treated accordingly.
  • One patient with stage I tumor developed widespread metastases and died.
  • Five stage I patients were alive and free of tumor at last follow-up.
  • In the differential diagnosis, anaplastic Wilms tumor, primary renal synovial sarcoma, malignant mesenchymoma, ectomesenchymoma, and mesenchymal chondrosarcomas have been considered but none of these tumors shared the same features as the 20 cases described here which represent a distinct clinicopathologic entity with morphologic features of a polyphenotypic anaplastic sarcoma of the kidney.
  • [MeSH-major] Kidney Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Child, Preschool. Desmin / analysis. Disease-Free Survival. Female. Gene Expression. Humans. Immunoenzyme Techniques. Infant. Male. Neoplasm Recurrence, Local. Neoplasm Staging. Nephrectomy. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Phenotype. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Vimentin / analysis

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  • (PMID = 17895746.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / SYT-SSX fusion protein; 0 / Vimentin
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90. Ramos KS, Nanez A: Genetic regulatory networks of nephrogenesis: deregulation of WT1 splicing by benzo(a)pyrene. Birth Defects Res C Embryo Today; 2009 Jun;87(2):192-7
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  • Recent studies have identified AHR as a master regulator of Wilms' tumor suppressor gene (WT1) signaling in the developing kidney.
  • Activation of AHR signaling by environmental chemical is associated with proteasome-mediated degradation of AHR protein, disruption of WT1 alternative splicing, and marked alterations in the regulation of genetic programs of developmental progression in the developing kidney.
  • The complexity of genetic regulatory networks of nephrogenesis controlled by AHR-WT1 interactions will be discussed here with particular emphasis given to the biological and medical consequences that may result from deficits in nephrogenesis that compromise reserve capacity and renal function later in life.
  • [MeSH-major] Benzo(a)pyrene / toxicity. Carcinogens / toxicity. Gene Expression Regulation, Developmental / genetics. Gene Regulatory Networks. Kidney / embryology. WT1 Proteins / genetics
  • [MeSH-minor] Adult. Alternative Splicing / drug effects. Alternative Splicing / genetics. Animals. Female. Humans. Mice. Mice, Knockout. Morphogenesis. Pregnancy. Rats. Receptor Cross-Talk / drug effects. Receptor Cross-Talk / physiology. Receptors, Aryl Hydrocarbon / drug effects. Receptors, Aryl Hydrocarbon / genetics. Receptors, Aryl Hydrocarbon / metabolism. Signal Transduction / drug effects. Signal Transduction / physiology. Young Adult

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  • (PMID = 19530133.001).
  • [ISSN] 1542-9768
  • [Journal-full-title] Birth defects research. Part C, Embryo today : reviews
  • [ISO-abbreviation] Birth Defects Res. C Embryo Today
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Receptors, Aryl Hydrocarbon; 0 / WT1 Proteins; 3417WMA06D / Benzo(a)pyrene
  • [Number-of-references] 69
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91. Pan CC, Epstein JI: Detection of chromosome copy number alterations in metanephric adenomas by array comparative genomic hybridization. Mod Pathol; 2010 Dec;23(12):1634-40
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  • Metanephric adenoma is a rare benign renal tumor typically found in adults.
  • We did not observe consistent gains of chromosomes 7 and 17, which are common in papillary renal cell carcinoma, neither did we find chromosomal alterations frequently present in Wilms' tumors, including chromosome gains of 1q, 7q, and 12, and losses of 11p and 16q.
  • Our series demonstrates that the genetic profile of metanephric adenoma is fundamentally distinct from those of papillary renal cell carcinoma and Wilms' tumor.
  • [MeSH-major] Adenoma / genetics. Kidney Neoplasms / genetics
  • [MeSH-minor] Adult. Comparative Genomic Hybridization. Female. Gene Dosage. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20802469.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Schumacher VA, Jeruschke S, Eitner F, Becker JU, Pitschke G, Ince Y, Miner JH, Leuschner I, Engers R, Everding AS, Bulla M, Royer-Pokora B: Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome. J Am Soc Nephrol; 2007 Mar;18(3):719-29
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  • Individuals with Denys-Drash syndrome (DDS) develop diffuse mesangial sclerosis, ultimately leading to renal failure.
  • The disease is caused by mutations that affect the zinc finger structure of the Wilms' tumor protein (WT1), but the mechanisms whereby these mutations result in glomerulosclerosis remain largely obscure.
  • Herein is described that in DDS podocytes, the ratio of both WT1 +KTS isoforms C to D differs considerably from that of normal child and adult control podocytes and more closely resembles fetal profiles.
  • The VEGF165/VEGF165b ratio in DDS resembles that of fetal S-shaped bodies, rather than that of normal child or adult control subjects.
  • [MeSH-major] Denys-Drash Syndrome / metabolism. Kidney Glomerulus / metabolism. Vascular Endothelial Growth Factor A / metabolism. WT1 Proteins / metabolism

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  • (PMID = 17267748.001).
  • [ISSN] 1046-6673
  • [Journal-full-title] Journal of the American Society of Nephrology : JASN
  • [ISO-abbreviation] J. Am. Soc. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / WT1 Proteins
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93. Becker JU, Hoerning A, Schmid KW, Hoyer PF: Immigrating progenitor cells contribute to human podocyte turnover. Kidney Int; 2007 Dec;72(12):1468-73
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  • We examined eight paraffin-embedded renal biopsies from six male recipients of female transplant kidneys for receiver-derived podocytes.
  • Fluorescent in situ hybridization for the Y chromosome was combined with immunofluorescence for the podocyte marker, Wilms tumor-1 antigen.
  • [MeSH-minor] Adult. Aged, 80 and over. Biopsy. Cell Count. Chromosomes, Human, Y. Female. Humans. In Situ Hybridization, Fluorescence. Kidney Transplantation. Male. Middle Aged

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  • (PMID = 17898701.001).
  • [ISSN] 0085-2538
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Wang G, Lai FM, Lai KB, Chow KM, Li KT, Szeto CC: Messenger RNA expression of podocyte-associated molecules in the urinary sediment of patients with diabetic nephropathy. Nephron Clin Pract; 2007;106(4):c169-79
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  • The mRNA expression of nephrin, podocin, synaptopodin, Wilms' tumor-1 (WT-1) and alpha-actinin-4 in urinary sediment were measured by real-time quantitative polymerase chain reaction.
  • Urinary nephrin and synaptopodin expressions are correlated with baseline clinical parameters such as proteinuria or renal function, while WT-1 expression is related to the degree of histological damage.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17596726.001).
  • [ISSN] 1660-2110
  • [Journal-full-title] Nephron. Clinical practice
  • [ISO-abbreviation] Nephron Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / RNA, Messenger
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95. Giannico G, Yang H, Neilson EG, Fogo AB: Dystroglycan in the diagnosis of FSGS. Clin J Am Soc Nephrol; 2009 Nov;4(11):1747-53
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  • DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We studied renal biopsies with FSGS, not otherwise specified (NOS), tip lesion, or collapsing variants (COLL), versus secondary FSGS or cases without segmental sclerotic lesions where a diagnosis of MCD versus FSGS could not be established (undefined [UNDEF]) and compared the expression of DG, FSP1, and podocyte Wilms' tumor antigen (WT1).

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  • (PMID = 19808230.001).
  • [ISSN] 1555-905X
  • [Journal-full-title] Clinical journal of the American Society of Nephrology : CJASN
  • [ISO-abbreviation] Clin J Am Soc Nephrol
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK-44757; United States / NIDDK NIH HHS / DK / DK-56942; United States / NIDDK NIH HHS / DK / P50 DK044757; United States / NIDDK NIH HHS / DK / DK-46282; United States / NIDDK NIH HHS / DK / R01 DK046282; United States / NIDDK NIH HHS / DK / R01 DK056942
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / WT1 Proteins; 146888-27-9 / Dystroglycans
  • [Other-IDs] NLM/ PMC2774958
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96. Zugor V, Zenker M, Schrott KM, Schott GE: [Frasier syndrome: a rare syndrome with WT1 gene mutation in pediatric urology]. Aktuelle Urol; 2006 Jan;37(1):64-6
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  • A Wilms tumor is seen only rarely in this clinical entity.
  • The patient became dependent on dialysis due to nethropathy in the form of focal sclerosing glomerulonephritis and terminal renal insufficiency.
  • A kidney transplantation in the left iliac fossa together with new implantation of the ureter according to Dodson.
  • [MeSH-minor] Adolescent. Adult. Atrophy. Child. Female. Germ-Line Mutation. Humans. Introns. Kidney Failure, Chronic / genetics. Male. Phenotype. Testis / pathology

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  • (PMID = 16440249.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / RNA Splice Sites; 0 / WTAP protein, human
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97. Sakairi T, Abe Y, Kajiyama H, Bartlett LD, Howard LV, Jat PS, Kopp JB: Conditionally immortalized human podocyte cell lines established from urine. Am J Physiol Renal Physiol; 2010 Mar;298(3):F557-67
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  • The expression of nephrin, Wilms' tumor 1 (WT1), and podocalyxin mRNA varied among the clones, which may be due to transformation and/or cloning.

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  • (PMID = 19955187.001).
  • [ISSN] 1522-1466
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Polyomavirus Transforming; 0 / Biomarkers; 0 / Genetic Markers; 0 / RNA, Messenger; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC2838606
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98. Ghavamzadeh A, Alimoghaddam K, Jahani M, Mousavi SA, Iravani M, Bahar B, Khodabandeh A, Khatami F, Ghaffari F, Jalali A: Stem cell transplantation; Iranian experience. Arch Iran Med; 2009 Jan;12(1):69-72
Genetic Alliance. consumer health - Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Stem cell transplantation was performed for various diseases including acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphoblastic leukemia, thalassemia major, sickle cell thalassemia, sickle cell disease, multiple myeloma, myelodysplasia, mucopolysaccharidosis, paroxysmal nocturnal hemoglobinuria, non-Hodgkin's lymphoma, Hodgkin's disease, severe aplastic anemia, plasma cell leukemia, Niemann-Pick disease, Fanconi anemia, severe combine immunodeficiency, congenital neutropenia, leukocyte adhesion deficiencies, Chediak-Higashi syndrome, osteopetrosis, histiocytosis X, Hurler syndrome, amyloidosis, systemic sclerosis, breast cancer, Ewing's sarcoma, testicular cancer, germ cell tumors, neuroblastoma, medulloblastoma, renal cell carcinoma, nasopharyngeal carcinoma, ovarian cancer, Wilms' tumor, rhabdomyosarcoma, pancreatoblastoma, and multiple sclerosis.
  • We had 105 cellular therapies for postmyocardial infarction, multiple sclerosis, cirrhosis, head of femur necrosis, and renal cell carcinoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Iran / epidemiology. Male. Middle Aged. Retrospective Studies. Survival Rate / trends. Treatment Outcome. Young Adult

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  • [ErratumIn] Arch Iran Med. 2009 May;12(3):329. Alimogaddam, Kamran [corrected to Alimoghaddam, Kamran]; Mousavi, Seyed Asadollah [corrected to Mousavi, Seied Asadollah]
  • [ErratumIn] Arch Iran Med. 2012 Aug;15(8):524
  • (PMID = 19111033.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Iran
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99. Badeloe S, van Spaendonck-Zwarts KY, van Steensel MA, van Marion AM, van Essen AJ, Jonkman MF, Steijlen PM, Poblete-Gutiérrez P, van Geel M, Frank J: Wilms tumour as a possible early manifestation of hereditary leiomyomatosis and renal cell cancer? Br J Dermatol; 2009 Mar;160(3):707-9
MedlinePlus Health Information. consumer health - Wilms Tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Wilms tumour as a possible early manifestation of hereditary leiomyomatosis and renal cell cancer?
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Kidney Neoplasms / genetics. Leiomyomatosis / genetics. Neoplastic Syndromes, Hereditary / genetics. Wilms Tumor / genetics
  • [MeSH-minor] Adult. DNA Mutational Analysis / methods. Female. Fumarate Hydratase / genetics. Humans. Mutation, Missense. Pedigree

  • Genetic Alliance. consumer health - Hereditary Cancer.
  • Genetic Alliance. consumer health - Kidney cancer.
  • MedlinePlus Health Information. consumer health - Kidney Cancer.
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  • (PMID = 19183174.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 4.2.1.2 / Fumarate Hydratase
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