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1. Beer S, Bellovin DI, Lee JS, Komatsubara K, Wang LS, Koh H, Börner K, Storm TA, Davis CR, Kay MA, Felsher DW, Grimm D: Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice. Mol Ther; 2010 Jan;18(1):161-70
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice.
  • As expected, the shRNAs silenced hepatic p53 and accelerated liver tumorigenesis when MYC was concurrently expressed.
  • In MYC-expressing transgenic mice, the marginal shRNA-induced liver injury sufficed to further stimulate hepatocellular division that was in turn associated with markedly increased expression of the mitotic cyclin B1.
  • Hence, even at low doses, shRNAs can cause low-level hepatoxicity that can facilitate the ability of the MYC oncogene to induce liver tumorigenesis.
  • [MeSH-major] Carcinoma, Hepatocellular / chemically induced. Genes, myc / physiology. Liver Neoplasms, Experimental / chemically induced. RNA, Small Interfering / adverse effects

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  • (PMID = 19844192.001).
  • [ISSN] 1525-0024
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01-CA03423; United States / NCI NIH HHS / CA / R01-CA89305; United States / NIDDK NIH HHS / DK / DK078424; United States / NCI NIH HHS / CA / F32-CA132312; United States / NCI NIH HHS / CA / R01 CA089305; United States / NCI NIH HHS / CA / F32 CA132312; United States / NIDDK NIH HHS / DK / R01 DK078424; United States / NCI NIH HHS / CA / P50-CA114747; United States / NCI NIH HHS / CA / R01 CA105102; United States / NCI NIH HHS / CA / R01-CA105102; United States / NCI NIH HHS / CA / P50 CA114747
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Small Interfering
  • [Other-IDs] NLM/ PMC2839214
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2. Lin HT, Liu GJ, Wu D, Lou JY: Metastasis of primary gallbladder carcinoma in lymph node and liver. World J Gastroenterol; 2005 Feb 7;11(5):748-51
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  • [Title] Metastasis of primary gallbladder carcinoma in lymph node and liver.
  • AIM: To evaluate the patterns with metastasis of gallbladder carcinoma in lymph nodes and liver.
  • The patterns with metastasis of primary gallbladder carcinoma in lymph nodes and liver were examined histopathologically and classified as TNM staging of the American Joint Committee on Cancer.
  • RESULTS: Of the 45 patients, 29 (64.4%) had a lymph node positive disease and 20 (44.4%) had a direct invasion of the liver.
  • The frequency of involvement of lymph nodes was strongly influenced by the depth of the primary tumor (P = 0.0001).
  • CONCLUSION: Complete resection of the regional lymph nodes is important in advanced primary gallbladder carcinoma (PGC).
  • The initial sites of liver spread are located mostly in segments IV and V.
  • [MeSH-major] Gallbladder Neoplasms / pathology. Liver Neoplasms / secondary. Lymphatic Metastasis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystectomy. Hepatectomy. Humans. Lymph Nodes / pathology. Lymph Nodes / surgery. Middle Aged. Neoplasm Staging

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  • (PMID = 15655837.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4250754
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3. Kang KF, Wang XW, Chen XW, Tan GM, Kang ZJ: [Expression of Beclin1 in primary hepatocellular carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Jan;29(1):151-3
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  • [Title] [Expression of Beclin1 in primary hepatocellular carcinoma].
  • OBJECTIVE: To detect Beclin1 expression and explore its clinical significance in primary hepatocellular carcinoma (HCC).
  • METHODS: Beclin1 expressions in 10 normal hepatic tissues, 30 hepatitis liver, 30 cirrhotic liver and 50 HCC tissues were detected by immunohistochemical staining.
  • RESULTS: The positivity rates of Beclin1 expression in the HCC, cirrhotic liver, hepatitis liver and normal liver tissues were 78.00% (39/50), 26.67% (8/30), 53.33% (16/30), and 10.00% (1/10), respectively, showing significant differences between them (chi(2)=28.31, P<0.05).
  • Beclin1 expression was significantly higher in HCC tissues than in the cirrhotic, hepatitis and normal liver tissues (chi(2)=20.39, 5.31, and 14.41, respectively, P<0.05), and hepatitis tissues showed significantly higher Beclin1 expression than hepatic cirrhosis tissues and normal hepatic tissues (chi(2)=4.44 and 4.12, respectively, P<0.05).
  • CONCLUSION: The abnormal expression of Beclin1 is closely associated with the pathogenesis and development of primary hepatocellular carcinoma, and may play an important role in this process.
  • [MeSH-major] Apoptosis Regulatory Proteins / metabolism. Carcinoma, Hepatocellular / metabolism. Liver Neoplasms / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 19218137.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BECN1 protein, human; 0 / Membrane Proteins
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4. Hoti E, Adam R: Liver transplantation for primary and metastatic liver cancers. Transpl Int; 2008 Dec;21(12):1107-17
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  • [Title] Liver transplantation for primary and metastatic liver cancers.
  • Liver transplantation for hepatic malignancies has emerged as a well-documented and proven treatment modality.
  • Currently, 15% of all liver transplants performed are for hepatocellular carcinoma (HCC).
  • There is no controversy about the fact that liver transplantation for HCC in the adult population yields good results for patients whose tumour masses do not exceed the Milan criteria.
  • In patients with small HCC at an early stage and preserved liver function, liver resection provides an alternative to transplant.
  • Liver resection may offer similar survival results to orthotopic liver transplantation (OLT) in the short term, and does not carry the long-term effects of immunosuppression; however, long-term and disease-free survival favours liver transplantation.
  • Survival rate in these selected patients can approach that of patients with cholestatic liver disease, and the role of transplantation now requires re-evaluation.
  • Epithelioid hemangioendothelioma is also an appropriate indication for liver transplantation, even in the presence of extrahepatic metastases, unlike angiosarcoma which is associated with a very poor survival and considered as a contraindication.
  • And finally for metastatic liver disease from neuroendocrine tumours, liver transplantation can result in long-term survival and even cure in well selected patients.
  • Conversely, the value of transplantation for colorectal liver metastases (currently a contraindication) requires further evaluation by well-designed trials.
  • [MeSH-major] Liver Neoplasms / pathology. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Bile Duct Neoplasms / surgery. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / surgery. Colorectal Neoplasms / pathology. Hemangioendothelioma / surgery. Hemangiosarcoma / surgery. Humans. Neoplasm Metastasis. Neoplasm Staging. Neuroendocrine Tumors / surgery. Survival Analysis. Survivors. Treatment Outcome

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  • (PMID = 18713148.001).
  • [ISSN] 0934-0874
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 75
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5. Ji SP, Li Q, Dong H: Therapy and prognostic features of primary clear cell carcinoma of the liver. World J Gastroenterol; 2010 Feb 14;16(6):764-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapy and prognostic features of primary clear cell carcinoma of the liver.
  • AIM: To clarify the therapeutic strategies and prognosis factors of primary clear cell carcinoma of the liver (PCCCL).
  • The Kaplan-Meier method showed that capsule formation, preoperative liver function, hepatitis C virus infection, large vascular invasion and multiple tumor occurrences were related to disease-free survival.
  • Cox regression analysis showed that the clear cell ratio, capsule formation, preoperative liver function and large vascular invasion were independent risk factors for overall survival.
  • Clear cell ratio, capsule formation, preoperative liver function, and vascular invasion were independent risk factors for prognosis.
  • [MeSH-major] Adenocarcinoma, Clear Cell / drug therapy. Adenocarcinoma, Clear Cell / surgery. Leucovorin / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / surgery. Tegafur / therapeutic use
  • [MeSH-minor] Adult. Aged. Antimetabolites, Antineoplastic / therapeutic use. Combined Modality Therapy. Female. Hepatectomy. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 20135727.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 1548R74NSZ / Tegafur; Q573I9DVLP / Leucovorin
  • [Other-IDs] NLM/ PMC2817067
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6. Liu ZZ, Huang WY, Lin JS, Li XS, Lan X, Cai XK, Liang KH, Zhou HJ: Cell survival curve for primary hepatic carcinoma cells and relationship between SF(2) of hepatic carcinoma cells and radiosensitivity. World J Gastroenterol; 2005 Nov 28;11(44):7040-3
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  • [Title] Cell survival curve for primary hepatic carcinoma cells and relationship between SF(2) of hepatic carcinoma cells and radiosensitivity.
  • AIM: To establish the cell survival curve for primary hepatic carcinoma cells and to study the relationship between SF(2) of primary hepatic carcinoma cells and radiosensitivity.
  • METHODS: Hepatic carcinoma cells were cultured in vitro using 39 samples of hepatic carcinoma at stages II-IV.
  • After these cells were radiated with different dosages, the cell survival ratio and SF(2) were calculated by clonogenic assay and SF(2) model respectively.
  • After X-ray radiation of the fifth generation cells with 0, 2, 4, 6, 8 Gy, the cell survival rate was 41%, 36.5%, 31.0%, 26.8%, and 19%, respectively.
  • There was a negative correlation between cell survival and irradiation dosage (r = -0.973, P<0.05).
  • SF(2) ranged 0.28-0.78 and correlated with the clinical stage and pathological grade of hepatic carcinoma (P<0.05).
  • CONCLUSION: SF(2) correlates with the clinical stage and pathological grade of hepatic carcinoma and is a marker for predicting the radiosensitivity of hepatic carcinomas.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / radiotherapy. Cell Survival. Liver Neoplasms / pathology. Liver Neoplasms / radiotherapy. Radiation Tolerance
  • [MeSH-minor] Adult. Aged. Animals. Cell Culture Techniques. Dose-Response Relationship, Radiation. Humans. Middle Aged. Neoplasm Staging. Tumor Cells, Cultured

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  • (PMID = 16437614.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4717052
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7. Liang SX, Zhu XD, Lu HJ, Pan CY, Li FX, Huang QF, Wang AY, Chen L, Fu XL, Jiang GL: Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma. Cancer; 2005 May 15;103(10):2181-8
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  • [Title] Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma.
  • BACKGROUND: The purpose of the current study was to evaluate the tolerance and efficacy of hypofractionated three-dimensional conformal radiotherapy (3DCRT) with or without transarterial chemoembolization (TACE) for technically unresectable or medically inoperable primary liver carcinoma (PLC).
  • Liver cirrhosis of Child-Pugh Grade A was found in 108 patients, and Grade B was found in 20 patients.
  • Radiation-induced liver disease (RILD) developed in 19 (15%) patients, of which 12 had Child-Pugh Grade B liver cirrhosis, and 7 had Grade A.
  • GTV and associated liver cirrhosis were identified by Cox regression analysis as independent predictors for survival (P = 0.044 and 0.015).
  • [MeSH-major] Carcinoma / radiotherapy. Liver Neoplasms / radiotherapy. Radiotherapy, Conformal / methods
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Chemoembolization, Therapeutic. Disease Progression. Dose Fractionation. Female. Follow-Up Studies. Gastroenteritis / etiology. Humans. Liver Cirrhosis / pathology. Liver Diseases / etiology. Male. Middle Aged. Radiation Injuries / etiology. Radiation Tolerance. Remission Induction. Survival Rate. Treatment Outcome

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  • (PMID = 15812834.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Tsai S, Gurakar A, Anders R, Lam-Himlin D, Boitnott J, Pawlik TM: Management of large hepatocellular carcinoma in adult patients with Alagille syndrome: a case report and review of literature. Dig Dis Sci; 2010 Nov;55(11):3052-8
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  • [Title] Management of large hepatocellular carcinoma in adult patients with Alagille syndrome: a case report and review of literature.
  • BACKGROUND: Alagille syndrome is a multi-system developmental disorder associated with paucity of interlobular bile ducts and cholestasis, rarely associated with hepatocellular carcinoma.
  • As such, we herein review the modern management of a large hepatocellular carcinoma in an adult patient with Alagille syndrome and review the literature of adult Alagille patients with hepatocellular carcinoma.
  • CASE PRESENTATION: A 29-year-old woman with a history of Alagille syndrome was referred with biopsy-proven 12 × 8 cm hepatocellular carcinoma replacing her right liver.
  • Biopsy of the contralateral liver demonstrated findings consistent with Alagille syndrome, but no underlying cirrhosis.
  • CT volumetrics demonstrated a future liver remnant of 40%.
  • [MeSH-major] Alagille Syndrome / epidemiology. Carcinoma, Hepatocellular / epidemiology. Carcinoma, Hepatocellular / surgery. Hepatectomy / methods. Liver Neoplasms / epidemiology. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Comorbidity. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed


9. Masuda T, Beppu T, Horino K, Komori H, Hayashi H, Okabe H, Ootao R, Horlad H, Baba Y, Miyase S, Takamori H, Baba H: Occurrence of hepatocellular carcinoma after hepatoblastoma resection in an adult with hepatitis C virus. Hepatol Res; 2009 May;39(5):525-30

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  • [Title] Occurrence of hepatocellular carcinoma after hepatoblastoma resection in an adult with hepatitis C virus.
  • In patients with no indication for a hepatic resection, the prognosis of adult hepatoblastoma is quite poor.
  • A 54-year-old man with hepatitis C virus-associated liver cirrhosis was initially treated with a hepatic resection for a hepatic tumor, 3 cm in diameter.
  • The tumor consisted of osteoid-like and cartilaginous foci, myxomatous stroma, and poorly differentiated hepatocellular carcinomatous cells and was diagnosed as a mixed epithelial and mesenchymal hepatoblastoma.
  • Two years after the first operation, multicentric hepatocellular carcinomas developed in the remnant liver and were successfully treated with a secondary hepatic resection combined with radio-frequency ablation.
  • To the best of our knowledge, the primary hepatoblastoma was the smallest such tumor reported and this is the first report of a metachronous hepatoblastoma and hepatocellular carcinoma in an adult hepatitis patient.

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  • (PMID = 19207587.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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10. Salguero FJ, Richard A, Gough J, Long A, Weyer U, Cooley WA, Chambers MA, Lesellier S: Pelioid hepatocellular carcinoma in an adult Eurasian badger (Meles meles). J Comp Pathol; 2010 Feb-Apr;142(2-3):208-12
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  • [Title] Pelioid hepatocellular carcinoma in an adult Eurasian badger (Meles meles).
  • A mass was identified within the left lateral lobe of the liver of a 10-year-old Eurasian badger (Meles meles).
  • The histological appearance was consistent with hepatocellular carcinoma (HCC).
  • [MeSH-major] Carcinoma, Hepatocellular / veterinary. Liver / pathology. Liver Neoplasms / veterinary. Mustelidae

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  • [Copyright] Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19683720.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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11. Wilson FD, Fitzgerald SD, Kiupel M, Walker RL, Williams CB, Todd DJ: Occurrence of hepatocellular carcinoma in an adult male Nile lechwe (Kobus megaceros). J Zoo Wildl Med; 2007 Jun;38(2):329-32
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  • [Title] Occurrence of hepatocellular carcinoma in an adult male Nile lechwe (Kobus megaceros).
  • The liver was grossly enlarged and contained a smooth-surfaced nodular mass that occupied the majority of the right lobe of the liver.
  • The mass had a liver-like appearance exhibiting a tan-red coloration but having a soft consistency.
  • To our knowledge, this is the first report in the scientific literature of a naturally occurring case of hepatocellular carcinoma in a Nile lechwe or in any antelope species.
  • [MeSH-major] Antelopes. Carcinoma, Hepatocellular / veterinary. Liver Neoplasms / veterinary

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  • (PMID = 17679519.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Sviteková M, Minár L, Pacovský Z: [Breast cancer in puerperium]. Klin Onkol; 2008;21(2):71-3
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  • [Transliterated title] Carcinoma mammae v puerperiu.
  • AIM: This case study reports an occurence of a mammary gland carcinoma in woman during her pregnancy and puerperium.
  • The core cut biopsy revealed invasive ductal carcinoma grade 3 and the staging was determinated as T4b N2 M1 (liver).
  • Because of the high clinical stage of the disease, primary sugical therapy (modified radical mastectomy) was not indicated and the patient underwent neoadjuvant chemotherapy followed byradiotherapy.
  • There was a control PET scan after the chemotherapy which confirmed only residual tumor in the area of affected breast and no viable tumor cells in the area of the liver.
  • Additional reduction of the primary tumor lesion occured after the radiotherapy.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Puerperal Disorders / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Pregnancy

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  • (PMID = 19102215.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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13. Ikeda S: [Adult-onset citrullinemia]. Brain Nerve; 2007 Jan;59(1):59-66
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  • [Title] [Adult-onset citrullinemia].
  • Adult-onset citrullinemia (CTLN2) is a rare hereditary metabolic disorder characterized by highly increased concentration of citrulline and ammonia in the plasma, which is ascribed to a deficiency of argininosuccinate synthetase (ASS), one of the urea cycle enzymes mainly located in the liver.
  • However, in 1995 the first CTLN2 patient who was successfully treated by living-related liver transplantation was reported and since then more than 30 patients had underwent this operation in our country, showing good outcomes.
  • No primary defect had not been found within ASS gene locus, but the causative gene of this disorder is now identified as the "citrin gene", which might act as a aspartate/glutamate transporter in mitochondria.
  • Different phenotypes are seen in the individuals with a citrin deficiency: neonatal intrahepatic cholestasis, juvenile-onset chronic pancreatitis and hepatocellular carcinoma without cirrhosis can precede the appearance of CTLN2.
  • [MeSH-minor] Administration, Oral. Adult. Age of Onset. Arginine / administration & dosage. Argininosuccinate Synthase. Calcium-Binding Proteins / genetics. Cholestasis, Intrahepatic / etiology. Chronic Disease. Glycerol / contraindications. Humans. Liver Neoplasms / etiology. Liver Transplantation. Mutation. Organic Anion Transporters / genetics. Pancreatitis / etiology. Phenotype

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  • (PMID = 17354380.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Organic Anion Transporters; 1340-08-5 / citrin; 94ZLA3W45F / Arginine; EC 6.3.4.5 / Argininosuccinate Synthase; PDC6A3C0OX / Glycerol
  • [Number-of-references] 34
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14. Ikeda S: [Adult-onset citrullinemia]. No To Shinkei; 2007 Jan;59(1):59-66
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  • [Title] [Adult-onset citrullinemia].
  • Adult-onset citrullinemia (CTLN2) is a rare hereditary metabolic disorder characterized by highly increased concentration of citrulline and ammonia in the plasma, which is ascribed to a deficiency of argininosuccinate synthetase (ASS), one of the urea cycle enzymes mainly located in the liver.
  • However, in 1995 the first CTLN2 patient who was successfully treated by living-related liver transplantation was reported and since then more than 30 patients had underwent this operation in our country, showing good outcomes.
  • No primary defect had not been found within ASS gene locus, but the causative gene of this disorder is now identified as the "citrin gene", which might act as a aspartate/glutamate transporter in mitochondria.
  • Different phenotypes are seen in the individuals with a citrin deficiency: neonatal intrahepatic cholestasis, juvenile-onset chronic pancreatitis and hepatocellular carcinoma without cirrhosis can precede the appearance of CTLN2.
  • [MeSH-minor] Administration, Oral. Age of Onset. Arginine / administration & dosage. Argininosuccinate Synthase. Calcium-Binding Proteins / genetics. Cholestasis, Intrahepatic / etiology. Chronic Disease. Glycerol / contraindications. Liver Neoplasms / etiology. Liver Transplantation. Mutation. Organic Anion Transporters / genetics. Pancreatitis / etiology. Phenotype

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  • (PMID = 17228780.001).
  • [ISSN] 0006-8969
  • [Journal-full-title] Nō to shinkei = Brain and nerve
  • [ISO-abbreviation] No To Shinkei
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Organic Anion Transporters; 1340-08-5 / citrin; 94ZLA3W45F / Arginine; EC 6.3.4.5 / Argininosuccinate Synthase; PDC6A3C0OX / Glycerol
  • [Number-of-references] 34
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15. Hervieu V, Lombard-Bohas C, Dumortier J, Boillot O, Scoazec JY: Primary acinar cell carcinoma of the liver. Virchows Arch; 2008 Mar;452(3):337-41
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  • [Title] Primary acinar cell carcinoma of the liver.
  • We report a case of acinar cell carcinoma primary to the liver.
  • The tumor was diagnosed in a 35-year-old woman complaining of abdominal pain and asthenia; serum alpha-fetoprotein (AFP) levels were increased at 6,000 IU/mL; imaging studies showed a hypervascular mass located in the left lobe of the liver.
  • The final diagnosis, based on histological, immunohistochemical, and ultrastructural arguments, was extra-pancreatic acinar cell carcinoma, primary to the liver.
  • This unusual lesion is likely to be the result of an abnormal differentiation pathway involving a transformed multipotential progenitor cell.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Liver / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Treatment Outcome. alpha 1-Antitrypsin / analysis. alpha-Fetoproteins / analysis

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  • (PMID = 18193278.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / alpha 1-Antitrypsin; 0 / alpha-Fetoproteins
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16. Klein WM, Molmenti EP, Colombani PM, Grover DS, Schwarz KB, Boitnott J, Torbenson MS: Primary liver carcinoma arising in people younger than 30 years. Am J Clin Pathol; 2005 Oct;124(4):512-8
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  • [Title] Primary liver carcinoma arising in people younger than 30 years.
  • Primary liver carcinomas in children and young adults are uncommon and poorly described.
  • We examined primary liver carcinomas in people younger than 30 years and performed immunostains for markers of biliary (cytokeratin [CK] 7, CK19, CD56) and hepatocellular (HepPar) differentiation.
  • We found 23 primary liver carcinomas were found: 13 hepatocellular carcinomas (HCCs), 9 fibrolamellar carcinomas (FLCs), and 1 cholangiocarcinoma.
  • In contrast, a control group of 65 adult HCCs showed less CK7 positivity (24 [37%]; P = .03).
  • No chronic background liver disease was seen, although 3 cases showed foci of altered hepatocytes.
  • HCCs are the most common primary liver carcinoma in children and young adults followed by FLCs.
  • They are morphologically similar to adult HCC, but more likely to be CK7(+).
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Animals. Antigens, CD56 / analysis. Bile Duct Neoplasms / chemistry. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / chemistry. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / analysis. Child. Child, Preschool. Female. Humans. Immunohistochemistry / methods. Keratin-7. Keratins / analysis. Male. Middle Aged. Retrospective Studies

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  • [CommentIn] Am J Clin Pathol. 2005 Oct;124(4):491-3 [16146817.001]
  • (PMID = 16146811.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / KRT7 protein, human; 0 / Keratin-7; 68238-35-7 / Keratins
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17. Liu Y, Sang XT, Gao WS, Mao YL, Liu YW, Liu HF, Yang ZY, Yang SZ, Zhong SX, Huang JF: [The first case of primary epithelial-myoepithelial carcinoma in the liver]. Zhonghua Wai Ke Za Zhi; 2006 Nov 1;44(21):1477-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The first case of primary epithelial-myoepithelial carcinoma in the liver].
  • OBJECTIVE: To report the first case of primary epithelial-myoepithelial carcinoma (EMC) in the liver.
  • A 10 cm lesion was detected in the right liver upon a routine examination.
  • CONCLUSIONS: Primary EMC is difficult to be finally diagnosed prior to the surgery.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis. Myoepithelioma / diagnosis
  • [MeSH-minor] Actins / analysis. Adult. Female. Hepatectomy / methods. Humans. Immunohistochemistry. Muscle, Smooth / chemistry. S100 Proteins / analysis

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  • (PMID = 17349174.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / S100 Proteins
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18. Ramírez Plaza CP, Santoyo Santoyo J, Domínguez López ME, Eloy-García Carrasco C, Cobo Dols M, Suárez Muñoz MA, Fernández Aguilar JL, de la Fuente Perucho A: [Adrenal carcinoma: 7 year disease free survival after complete primary tumor resection and repeated resection of local-regional and distant recurrences. Review after one case with poor initial life expectancy]. Arch Esp Urol; 2005 Mar;58(2):115-9
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  • [Title] [Adrenal carcinoma: 7 year disease free survival after complete primary tumor resection and repeated resection of local-regional and distant recurrences. Review after one case with poor initial life expectancy].
  • [Transliterated title] Carcinoma suprarrenal: supervivencia a 7 años libre de enfermedad tras resección completa del tumor primario y resecciones repetidas de recidivas locorregional y a distancia. Revisión a raiz de un caso con una pobre esperanza de vida inicial.
  • OBJECTIVES: We report the case of a female patient with adrenal carcinoma who had undergone surgery and presented with local-regional and distant recurrences, emphasizing the importance of the aggressive surgical treatment to achieve long-term survival which is unexpected sometimes.
  • METHODS/RESULTS: We report the case of a 29-year-old female patient who consulted for left flank pain, being diagnosed of an adrenal tumor by radiological tests; she underwent surgical excision of a left adrenal carcinoma (stage II).
  • Later on she presented with local-regional recurrences (2 times) and distant metastases (liver) undergoing excision in three procedures.
  • Nevertheless, an aggressive surgical approach of local recurrences and metastasic disease may significantly prolong patient's survival and, sometimes, leave the patient disease free several years after the diagnosis of the primary tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Carcinoma / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Humans. Reoperation. Time Factors

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  • (PMID = 15847268.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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19. Xuan SY, Li N, Shi YX, Sun Y, Zhang J, Jiang WJ, Qiang X: [Association between Helicobacter infection in liver tissue and primary liver carcinoma]. Zhonghua Yi Xue Za Zhi; 2005 Feb 16;85(6):391-5
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  • [Title] [Association between Helicobacter infection in liver tissue and primary liver carcinoma].
  • OBJECTIVE: To investigate the relationship between Helicobacter species and primary liver carcinoma (PLC).
  • METHODS: The liver samples resected during operation from 21 patients with PLC diagnosed by histopathology and 12 patients with other liver diseases as controls were studied.
  • Helicobacter species in liver specimens from the studied subjects were examined by PCR with Helicobacter specific 16SrRNA primers.
  • Qualitative and quantitative studies were used to assess the correlation of liver tissue helicobacter infection with PLC.
  • CONCLUSION: Helicobacter infection may exist in the liver tissues of PLC patients with a high infection rate, suggesting an association between Helicobacter infection and PLC.
  • [MeSH-major] Carcinoma, Hepatocellular / microbiology. Helicobacter. Helicobacter Infections. Liver / microbiology. Liver Neoplasms / microbiology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. RNA, Bacterial / analysis. RNA, Ribosomal, 16S / analysis. Sequence Analysis, DNA

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  • (PMID = 15854528.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Bacterial; 0 / RNA, Ribosomal, 16S
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20. Zhong XG, He S, Yin W, Deng JY, Chen B: [Tropism of adult liver stem cells toward hepatocellular carcinoma cells in vitro]. Zhonghua Gan Zang Bing Za Zhi; 2005 Sep;13(9):644-7
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  • [Title] [Tropism of adult liver stem cells toward hepatocellular carcinoma cells in vitro].
  • OBJECTIVE: To explore the biological behavior of adult liver stem cells in a co-cultured system of them with hepatocellular carcinoma (HCC) cells without direct contact between the two kinds of cells.
  • METHODS: WB-F344, a kind of rat adult liver stem cell, and rat embryonic fibroblasts (REF) from a primary culture were engineered to express enhanced green fluorescent protein (EGFP) by recombinant adenoviral-mediated methods.
  • After the HCC cells grew to 40%-60% confluence in the culture dish with a 10-mm cell-free area, a similar number of WB-EGFP and REF-EGFP were placed in the blank areas respectively.
  • Their appearance was found not only when WB-EGFP cells were seeded into the cell-free area at the center of the dish, but also when seeded into the blank area at the extreme edge of the plate.
  • CONCLUSIONS: The results mean that adult liver stem cells have a biological behavior of selective tropism toward HCC cells in vitro, and suggest a possibility of using migratory liver stem cells as a delivery vehicle for gene therapy for HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver / cytology. Liver Neoplasms / pathology. Stem Cells / cytology

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  • (PMID = 16174449.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Ali S, Shah V: Small-duct primary sclerosing cholangitis with hepatocellular carcinoma requiring liver transplantation. Hepatobiliary Pancreat Dis Int; 2010 Apr;9(2):208-12
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  • [Title] Small-duct primary sclerosing cholangitis with hepatocellular carcinoma requiring liver transplantation.
  • BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease, which usually affects young adults and is diagnosed by cholangiography.
  • METHODS: A 31-year-old man presented with severe hematemesis secondary to liver cirrhosis.
  • Over a course of 8 years, his liver decompensated and required an orthotopic liver transplantation.
  • RESULTS: The patient's explanted liver showed changes of PSC affecting only the small- and medium-sized bile ducts in addition to three incidental nodules of hepatocellular carcinoma.
  • CONCLUSIONS: Small-duct PSC has a substantially better prognosis than the large-duct type, with less chance of developing cirrhosis and an equal risk for developing hepatocellular carcinoma, but no increased risk for developing cholangiocarcinoma.
  • Liver transplantation remains the ultimate cure.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Cholangitis, Sclerosing / surgery. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Adult. Humans. Male


22. Zhang TL, Ma SH, Xiu DR, Song SB, Yuan CH, Jia YM, Gong EC: [The pathological feature of primary hepatic carcinoma on explanted liver and its significance]. Zhonghua Wai Ke Za Zhi; 2010 Jul 1;48(13):964-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The pathological feature of primary hepatic carcinoma on explanted liver and its significance].
  • OBJECTIVE: To investigate the pathological feature of primary hepatic carcinoma and the clinical significance.
  • METHODS: From August 2000 to December 2007, there were 89 patients with cirrhosis and carcinoma of liver who accepted whole liver resection.
  • The whole liver was cut into 10 mm slices to examine the tumor size, number, distribution, capsule, satellite nodes, portal vein tumor thrombi (PVTT).
  • RESULTS: The total of 89 cases included hepatocellular carcinoma in 86 cases and cholangiocarcinoma in 3 cases; 53 cases with multiple tumors and 36 cases with solitary tumor; complete capsule only in 14 cases, no obvious margin in 11 cases, 13 cases had a major tumor in the right lobe and a small tumor in the left lobe; 8 of 25 cases with gross invaded tissue were confirmed by histological examination, 7 of 16 cases with swollen lymph nodes were infiltrated by cancer cells.
  • CONCLUSIONS: The whole explanted liver can completely reflect the characteristics of growth and infiltration of hepatic carcinoma.
  • Attention must be paid to the small cancer lesions in another lobe, distal satellite nodes from major tumor, and tumor thrombi in a small branch of portal vein, which can not be found by imaging, and might influence the curative effectiveness after liver resection or transplantation.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Hepatectomy. Humans. Liver / pathology. Male. Middle Aged. Young Adult

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  • (PMID = 21054976.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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23. Konopke R, Distler M, Ludwig S, Kersting S: Location of liver metastases reflects the site of the primary colorectal carcinoma. Scand J Gastroenterol; 2008;43(2):192-5
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  • [Title] Location of liver metastases reflects the site of the primary colorectal carcinoma.
  • OBJECTIVE: The present study was designed to investigate whether the different venous return of different locations of colorectal carcinomas affects the lobar distribution of metastases to the liver, due to the "streaming" within the portal vein.
  • MATERIAL AND METHODS: The site of the primary colorectal carcinoma was divided into the right- and left hemicolon according to the different venous drainage via the superior and the inferior mesenteric/splenic vein.
  • Both groups were analyzed for the distribution of the metastases in the liver.
  • The anatomic site of the liver metastases was detected by intraoperative exploration and differentiated between the two lobes using the Cantlie line.
  • The ratio of metastases in the right and left hemiliver was 3.6:1 for 35 right-sided primary tumors (p=0.002) compared with 2.1:1 for 143 left-sided primary tumors (p=NS).
  • No significant differences were evident for the sub-analysis of involved liver segments.
  • Right-sided colon carcinomas predominantly involve the right hemiliver, while left-sided colon carcinomas involve the liver homogeneously, considering the size ratio of the right to left liver lobe, which is about 2:1.
  • Knowledge of streaming may help us to understand the spread of abdominal malignancies and may provide a reference concerning the possible primary site depending on metastatic distribution in the liver.
  • [MeSH-major] Carcinoma / secondary. Colorectal Neoplasms / pathology. Liver Circulation. Liver Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cecum / blood supply. Cecum / pathology. Female. Humans. Liver / blood supply. Liver / pathology. Male. Mesenteric Veins. Middle Aged. Neoplastic Cells, Circulating / pathology. Portal Vein

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  • (PMID = 17918001.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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24. Xu L, Zhou Y, Qiu D: Correlation between calcified liver metastases and histopathology of primary colorectal carcinoma in Chinese. J Huazhong Univ Sci Technolog Med Sci; 2010 Dec;30(6):815-8
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  • [Title] Correlation between calcified liver metastases and histopathology of primary colorectal carcinoma in Chinese.
  • The study examined the association between calcified liver metastases and the histopathology of the primary colorectal carcinoma in Chinese.
  • The clinical, pathological and CT data were retrospectively analyzed in 210 patients (mean age: 54.2 years) with liver metastases from colorectal carcinoma.
  • All patients had no history of chronic liver diseases and had never received interventional treatments.
  • χ(2)-test was used to analyze the rate of calcification in the liver metastasis from colorectal cancer of different differentiation degrees.
  • Among the 210 cases of liver metastases, 22 patients (10.5%) were found to have calcified liver metastases on CT scan.
  • Two patients with calcified liver metastasis received lumpectomy and developed calcification in recurrent tumors.
  • And the calcification in the newly developed masses was similar to that of their primary counterparts in terms of morphology and distribution.
  • Histopathologically, the primary tumors were well-differentiated adenocarcinoma in 6 cases, moderately-differentiated adenocarcinoma in 10, poorly-differentiated adenocarcinoma in 4 and mucinous adenocarcinoma in 2 among the 22 cases.
  • No statistical correlation was noted between the incidence of calcified liver metastasis and the pathological subtypes and differentiation degrees of the primary colorectal carcinoma.
  • It was concluded that calcified liver metastases may result from colorectal adenocarcinomata of different differentiation degrees or mucinous adenocarcinomata in Chinese population.
  • There is no correlation between calcification of liver metastases and the pathological subtype of the primary colorectal carcinoma in Chinese, which is different from the findings that calcified metastases were associated with colorectal mucinous adenocarcinoma in other ethnic groups.
  • [MeSH-major] Calcinosis / pathology. Colorectal Neoplasms / pathology. Liver / pathology. Liver Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Adult. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 21181378.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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25. Roman S: Adrenocortical carcinoma. Curr Opin Oncol; 2006 Jan;18(1):36-42
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  • [Title] Adrenocortical carcinoma.
  • PURPOSE OF REVIEW: Adrenocortical carcinoma is a rare malignancy, accounting for 0.02% of all annual cancers reported.
  • While older studies purported an improved outcome for functional tumors in adult patients, this has not been borne out in more recent studies.
  • RECENT FINDINGS: Recent studies focusing on the tumorigenesis of adrenocortical carcinoma have focused on onco-developmental genes present in the fetal adrenal cortex, as well as local adrenal paracrine and autocrine effects of cellular peptides.
  • No significant advances in the treatment of adrenocortical carcinoma have been developed.
  • Surgery remains the mainstay for primary and recurrent disease, including select patients with isolated liver metastases.
  • [MeSH-major] Adrenal Cortex Neoplasms. Adrenocortical Carcinoma

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  • (PMID = 16357562.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Vascular Endothelial Growth Factor A; 104625-48-1 / Activins; 57285-09-3 / Inhibins; 78E4J5IB5J / Mitotane
  • [Number-of-references] 38
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26. Balta Z, Sauerbruch T, Hirner A, Büttner R, Fischer HP: [Primary neuroendocrine carcinoma of the liver. From carcinoid tumor to small-cell hepatic carcinoma: case reports and review of the literature]. Pathologe; 2008 Feb;29(1):53-60
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  • [Title] [Primary neuroendocrine carcinoma of the liver. From carcinoid tumor to small-cell hepatic carcinoma: case reports and review of the literature].
  • Primary hepatic neuroendocrine tumors are rare neoplasms.
  • While primary hepatic carcinoid tumors (PHCT) are well-differentiated tumors, primary hepatic small-cell carcinomas (PHSCC) represent the poorly differentiated end of the spectrum of neuroendocrine carcinomas.
  • The second patient suffered from small-cell carcinoma of the liver.
  • There were no risk factors for a hepatocellular carcinoma.
  • An extensive preoperative and postoperative diagnostic investigation could rule out an extrahepatic primary site.
  • After neoadjuvant cytostatic treatment the carcinoma was completely extirpated and 18 months after treatment the patient is healthy.PHCT and PHSCC have to be clearly separated from hepatocellular and cholangiocellular carcinomas.
  • Exclusion of an extrahepatic primary site requires an accurate and synoptic analysis of clinical, radiologic and pathologic findings.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoid Tumor / pathology. Carcinoma / drug therapy. Carcinoma / pathology. Carcinoma, Neuroendocrine / pathology. Liver Neoplasms / drug therapy. Liver Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Carboplatin / administration & dosage. Cell Differentiation. Etoposide / administration & dosage. Female. Follow-Up Studies. Humans. Rectal Neoplasms / pathology. Risk Factors. Treatment Outcome


27. Otegbayo JA, Yakubu A, Akere A, Igetei R, Aje AO: Quality of life among primary liver cell carcinoma patients in Ibadan, Nigeria. Afr J Med Med Sci; 2005 Mar;34(1):51-4
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  • [Title] Quality of life among primary liver cell carcinoma patients in Ibadan, Nigeria.
  • A descriptive prospective study was conducted to evaluate the quality of life of patients with primary liver cell carcinoma at the University College Hospital, Ibadan, Nigeria.
  • [MeSH-major] Carcinoma / psychology. Liver Neoplasms / psychology. Quality of Life. Sickness Impact Profile
  • [MeSH-minor] Adult. Aged. Female. Hospitals, University. Humans. Male. Middle Aged. Nigeria. Patient Satisfaction. Prognosis. Prospective Studies. Surveys and Questionnaires

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  • (PMID = 15971554.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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28. Zhang K, Tang W, Qu X, Guo Q, Inagaki Y, Seyama Y, Abe H, Gai R, Kokudo N, Sugawara Y, Nakata M, Makuuchi M: KL-6 mucin in metastatic liver cancer tissues from primary colorectal carcinoma. Hepatogastroenterology; 2009 Jul-Aug;56(93):960-3
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  • [Title] KL-6 mucin in metastatic liver cancer tissues from primary colorectal carcinoma.
  • This study aimed to assess subcellular localization of KL-6 mucin in liver metastatic tissues from colorectal carcinoma and hepatocellular carcinoma tissues.
  • METHODOLOGY: Tissue samples were collected from 56 patients with liver metastasis of colorectal carcinoma and 92 patients with hepatocellular carcinoma who underwent a hepatectomy.
  • RESULTS: All 56 cases with metastatic liver cancer showed positive staining for KL-6 mucin in cancer tissues but not in non-cancerous tissues.
  • In contrast, no staining for KL-6 mucin was observed in either cancerous or non-cancerous tissues of the 92 patients with hepatocellular carcinoma.
  • CONCLUSIONS: KL-6 mucin may be an indicator for liver metastasis of colorectal carcinoma.
  • Additionally, detection of KL-6 mucin may be helpful in distinguishing hepatocellular carcinoma from metastatic liver cancer.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Carcinoma, Hepatocellular / metabolism. Colorectal Neoplasms / pathology. Liver Neoplasms / metabolism. Liver Neoplasms / secondary. Mucin-1 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged


29. Ye XP, Li LQ, Peng T, Xiao KY, Su ZX, Shang LM, Su M, Xu BH: [Diagnosis and treatment of primary clear cell carcinoma of the liver]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):64-6
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  • [Title] [Diagnosis and treatment of primary clear cell carcinoma of the liver].
  • OBJECTIVE: To investigate the clinicopathological features, diagnosis, treatment and prognosis of primary clear cell carcinoma of the liver (PCCCL).
  • Liver cirrhosis was found in 75.0% of the patients.
  • CONCLUSION: The clinical characteristics of primary clear cell carcinoma of the liver are similar to that of common hepatocellular carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / surgery. Hepatectomy. Liver Neoplasms / pathology. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hepatitis B. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Survival Rate. alpha-Fetoproteins / analysis

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  • (PMID = 20211073.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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30. Lao XM, Zhang YQ, Jin X, Lin XJ, Guo RP, Li GH, Li JQ: Primary clear cell carcinoma of liver--clinicopathologic features and surgical results of 18 cases. Hepatogastroenterology; 2006 Jan-Feb;53(67):128-32
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  • [Title] Primary clear cell carcinoma of liver--clinicopathologic features and surgical results of 18 cases.
  • BACKGROUND/AIMS: Primary clear cell carcinoma of the liver (PCCCL) is a subgroup of hepatocellular carcinoma.
  • The differentiation degree ranged from grade 1 to 3, liver cirrhosis or/and chronic hepatitis was present in paratumorous tissues.
  • The clinical characteristics of the PCCCL are similar to those of conventional hepatocellular carcinoma.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Liver Neoplasms / pathology. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 16506391.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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31. Schiel KA: An etiologic model proposing that sporadic adult-onset carcinoma is extramedullary hematopoiesis. Med Hypotheses; 2006;67(1):93-109
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  • [Title] An etiologic model proposing that sporadic adult-onset carcinoma is extramedullary hematopoiesis.
  • This model proposes that primary carcinomatous tumors and almost all metastases are extramedullary hematopoietic tissue formed to compensate for reduced hematopoietic activity in the bone marrow.
  • Specific carcinoma morphologies are equated to stages in endochondral bone and marrow formation and, as such, cancer cell identity varies with morphology.
  • Tubular breast carcinoma, with its single layer of osteoblast-like carcinoma cells encircling small lumens and long branching tubules, is equated to the trabecular stage of marrow formation during which osteoblasts surround small pieces of calcified cartilage and begin secreting osteoid that will form the trabeculae.
  • Lobular carcinoma in situ consists of cancer cell clusters separated by narrow clear spaces that, under high magnification, appear vascular.
  • If this model is correct it necessitates a change in the treatment of carcinoma.
  • [MeSH-major] Carcinoma / etiology. Hematopoiesis, Extramedullary. Liver Neoplasms / etiology
  • [MeSH-minor] Adult. Bone Marrow Cells. Granulocytes / metabolism. Hematopoietic Stem Cells / cytology. Humans. Leukemia / metabolism. Models, Biological. Neoplasm Metastasis. Primary Myelofibrosis / pathology

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  • (PMID = 16540257.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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32. Gruttadauria S, Marsh JW, Cintorino D, Biondo D, Luca A, Arcadipane A, Vizzini G, Volpes R, Marcos A, Gridelli B: Adult to adult living-related liver transplant: report on an initial experience in Italy. Dig Liver Dis; 2007 Apr;39(4):342-50
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  • [Title] Adult to adult living-related liver transplant: report on an initial experience in Italy.
  • INTRODUCTION: Living-related liver transplantation has become the treatment of choice for many liver diseases.
  • We present our initial analysis of 53 cases of adult to adult living-related liver transplantation performed in a single institute in Italy.
  • MATERIALS AND METHODS: From January 2002 to September 2006, we performed 53 adult to adult living-related liver transplantations.
  • Recipients (ages 18-68) suffered from cirrhosis secondary to viral etiology (18), hepatocellular carcinoma with viral cirrhosis (24), cystic fibrosis (2), primary biliary cirrhosis (2), hepatocellular carcinoma with non-viral cirrhosis (2), alcoholic cirrhosis (1), ornithine transcarbamylase deficiency (OTC), (1) criptogenic cryptogenic cirrhosis, (1) primary sclerosing cholangitis, (1) biliary atresia and metastatic carcinoid (1).
  • Donor liver resection resulted in 51 right hepatectomies and two left hepatectomies.
  • CONCLUSION: Adult to adult living-related liver transplantation represents a resource to be used in confronting organ shortage, and is a valuable option for decreasing mortality and drop out from the waiting list.
  • [MeSH-major] Liver Transplantation / statistics & numerical data. Living Donors
  • [MeSH-minor] Adolescent. Adult. Donor Selection. Female. Graft Rejection / epidemiology. Graft Survival. Humans. Italy / epidemiology. Liver Diseases / mortality. Liver Diseases / surgery. Male. Middle Aged. Recurrence. Reoperation / statistics & numerical data. Treatment Outcome

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  • (PMID = 17337259.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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33. Yan LN, Li B, Zeng Y, Wen TF, Wang WT, Yang JY, Xu MQ, Chen ZY, Zhao JC, Ma YK, Wu H: [Analysis of fifty adult to adult living donor liver transplantation]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2007 Jun;38(3):513-7
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  • [Title] [Analysis of fifty adult to adult living donor liver transplantation].
  • OBJECTIVE: To investigate the safety of adult-to-adult living donor liver transplantation (AALDLT), which means how to make the life safeties of both adult donor and recipient who are transplanted with the right lobe of liver.
  • METHODS: From January 2002 to July 2006, 50 A-ALDLT were performed at West China Hospital, Sichuan University, which consisted of 47 cases with right lobe graft without middle hepatic vein (MHV) and 3 cases with the dual graft of liver lobes (one cases with two left lobes, 2 with one right and one left lobe).
  • The majority of adult liver recipients suffered originally from the hepatitis B with liver cirrhosis (60%), hepatocellular carcinoma (30%) as primary diseases, and 10 cases among them had the model of end-stage liver disease (MELD) score more than 25.
  • RESULTS: From 52 living donors, 49 right liver lobes and 3 left lobes were obtained.
  • All of the donor remnant liver volumes were larger 35% of the whole liver volume.
  • 69% of donors undergoing complications in 50 adult recipients.
  • CONCLUSION When preoperative CT volume showed the volume of remnant liver is greater than 35% of whole liver volume, and the ratio of right lobe graft volume to recipient's standard live volume is more than 40% , A-ALDLT using right lobe graft should be very safe procedure for both donors and recipients, otherwise the dual graft liver transplantation should be considered.
  • [MeSH-major] Liver Transplantation / methods. Living Donors
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Liver / pathology. Liver / radiography. Male. Middle Aged. Organ Size. Survival Rate. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 17593845.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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34. Vitale A, Boccagni P, Brolese A, Neri D, Srsen N, Zanus G, Pagano D, Pauletto A, Bonsignore P, Scopelliti M, D'Amico FE, Ometto G, Polacco M, Burra P, Gambato M, Feltracco P, Romano A, Cillo U: Progression of hepatocellular carcinoma before liver transplantation: dropout or liver transplantation? Transplant Proc; 2009 May;41(4):1264-7
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  • [Title] Progression of hepatocellular carcinoma before liver transplantation: dropout or liver transplantation?
  • BACKGROUND: Tumor progression before liver transplantation (OLT) is the main cause of dropout from the waiting list (WL) of patients with hepatocellular carcinoma (HCC).
  • Adult patients with benign chronic liver disease enlisted for primary OLT in the same period represented the control group.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Patient Dropouts
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Waiting Lists. Young Adult

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  • (PMID = 19460534.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Xu ZY, Liang SX, Zhu J, Zhu XD, Zhao JD, Lu HJ, Yang YL, Chen L, Wang AY, Fu XL, Jiang GL: Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma. Int J Radiat Oncol Biol Phys; 2006 May 1;65(1):189-95
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  • [Title] Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma.
  • PURPOSE: To describe the probability of RILD by application of the Lyman-Kutcher-Burman normal-tissue complication (NTCP) model for primary liver carcinoma (PLC) treated with hypofractionated three-dimensional conformal radiotherapy (3D-CRT).
  • Of these patients, 93 were in liver cirrhosis of Child-Pugh Grade A, and 16 were in Child-Pugh Grade B.
  • [MeSH-major] Liver / radiation effects. Liver Neoplasms / radiotherapy. Models, Biological. Radiation Injuries / etiology. Radiotherapy, Conformal / adverse effects
  • [MeSH-minor] Adult. Aged. Chemoembolization, Therapeutic / methods. Dose Fractionation. Female. Follow-Up Studies. Humans. Likelihood Functions. Male. Middle Aged. Models, Statistical. Radiation Tolerance

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  • [CommentIn] Int J Radiat Oncol Biol Phys. 2006 Nov 15;66(4):1272; author reply 1272-3 [17145543.001]
  • (PMID = 16542787.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. Soeda J, Yazaki M, Nakata T, Miwa S, Ikeda S, Hosoda W, Iijima M, Kobayashi K, Saheki T, Kojiro M, Miyagawa S: Primary liver carcinoma exhibiting dual hepatocellular-biliary epithelial differentiations associated with citrin deficiency: a case report. J Clin Gastroenterol; 2008 Aug;42(7):855-60
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  • [Title] Primary liver carcinoma exhibiting dual hepatocellular-biliary epithelial differentiations associated with citrin deficiency: a case report.
  • We report a 50-year-old male patient with primary liver carcinoma exhibiting dual hepatocellular and biliary epithelial differentiations associated with citrin deficiency (asymptomatic adult-onset type II citrullinemia, CTLN2).
  • Although so far 14 CTLN2 patients with hepatocellular carcinoma have been reported, this report describes a unique case of liver carcinoma showing the features of both hepatocellular and cholangiocellular carcinoma.
  • In addition to the clinical data of the 14 patients reported previously, the findings in our patient suggest that the citrin deficiency might be one of the key disorders causing hepatocellular carcinoma especially at younger ages and can also play an important role in hepatocarcinogenesis of the hepatic progenitor cells, which have the bipotential to differentiate into both hepatocytes and cholangiocytes.
  • [MeSH-major] Bile Duct Neoplasms. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular. Cholangiocarcinoma. Citrullinemia / complications. Liver Neoplasms
  • [MeSH-minor] Cell Differentiation. Hepatectomy. Humans. Liver / cytology. Liver / pathology. Liver Failure / etiology. Male. Middle Aged

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  • (PMID = 18385606.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Kulig J, Skuciński J, Gach T, Hodorowicz-Zaniewska D, Nowak W, Kołodziejczyk P, Sierzega M: [Radiofrequency ablation of the primary and secondary liver malignancies]. Przegl Lek; 2005;62(5):287-91
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  • [Title] [Radiofrequency ablation of the primary and secondary liver malignancies].
  • For primary liver tumors and selected cases of colorectal liver metastases, surgical resection with preserved oncological margins of healthy tissue has been a method of choice.
  • The criteria that decide about qualifying the patients to surgical resections include the number of nodules, size, localization, infiltrations to vessels or neighboring organs, liver functions, and patient's general condition.
  • These low rates encourage the search for the effective methods of primary and secondary liver tumors destruction with low complication rates.
  • The authors review the results of radiofrequency thermal ablation (RFA) used to treat hepatocellular carcinoma and colorectal metastases in 65 patients, who underwent 178 RFA procedures (143 percutaneous and 35 during laparotomy).
  • RFA is recommended as effective method with low rates of complications to be used for palliative treatment of unresectable primary and secondary liver malignancies.
  • [MeSH-major] Carcinoma, Hepatocellular / secondary. Carcinoma, Hepatocellular / surgery. Catheter Ablation. Liver Neoplasms / secondary. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Female. Humans. Male. Middle Aged. Poland. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 16334534.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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38. Burri E, Steuerwald M, Cathomas G, Mentha G, Majno P, Rubbia-Brandt L, Meier R: Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver. Eur J Gastroenterol Hepatol; 2006 Apr;18(4):437-41
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  • [Title] Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver.
  • Liver-cell adenomas are benign lesions of the liver occurring predominantly in young women.
  • Hepatocellular carcinomas in most of the cases arise in a cirrhotic liver during the fifth or sixth decade.
  • Tests for chronic liver diseases were negative.
  • The tumour was surgically removed and a hepatocellular carcinoma arising within a liver-cell adenoma in a non-cirrhotic liver was found.
  • Malignant transformation of liver-cell adenoma has only been reported in a few case reports.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 16538118.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 42
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39. Liu XB, Yuan ZY, Song YC, Li FT, Dong Y, Wang JS, Li XY, Wang P: [An initial report of cyberknife radiosurgery for primary hepatic carcinoma]. Zhonghua Zhong Liu Za Zhi; 2010 Mar;32(3):229-33
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  • [Title] [An initial report of cyberknife radiosurgery for primary hepatic carcinoma].
  • OBJECTIVE: To study the efficacy and toxicity of cyberknife radiosurgery for primary hepatic carcinoma.
  • METHODS: From September 2006 to March 2008, 17 patients with clinical stage I-III primary hepatic carcinoma were treated with cyberknife at Tianjin Cancer Hospital.
  • Totally 23 lesions in the liver were treatment.
  • All the lesions in liver treated by the cyberknife radiosurgery achieved local control.
  • CONCLUSION: The cyberknife radiosurgery for primary hepatic carcinoma showed a high rate of local control and minimal toxicity.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Female. Fiducial Markers. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Remission Induction. Survival Rate

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  • (PMID = 20450595.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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40. Fan YZ, Sun W, Zhang WZ, Ge CY: [Vasculogenic mimicry in human primary gallbladder carcinoma and clinical significance thereof]. Zhonghua Yi Xue Za Zhi; 2007 Jan 16;87(3):145-9
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  • [Title] [Vasculogenic mimicry in human primary gallbladder carcinoma and clinical significance thereof].
  • OBJECTIVE: To investigate if there is vasculogenic mimicry (VM) in human primary gallbladder carcinoma and clinical significance thereof.
  • METHODS: Seventy-four specimens of primary gallbladder carcinoma obtained from operation underwent HE staining and double staining of CD(31) and PAS to observe the existence of VM.
  • Cox analysis showed that existence of VM, invasion depth, lymph node metastasis, hepatic metastasis, and operational method were independent risk factors of the prognosis of primary gallbladder carcinoma.
  • CONCLUSION: VM exists in human primary gallbladder carcinoma.
  • Those cases of human primary gallbladder carcinoma with VM have a poorer prognosis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD31 / analysis. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Prognosis. Survival Analysis

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  • (PMID = 17425842.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31
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41. Malik SM, Gupte PA, de Vera ME, Ahmad J: Liver transplantation in patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma. Clin Gastroenterol Hepatol; 2009 Jul;7(7):800-6
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  • [Title] Liver transplantation in patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma.
  • BACKGROUND & AIMS: The increasing incidence of hepatocellular carcinoma in the United States is only partially accounted for by hepatitis C virus (HCV) infections.
  • The prevalence of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis (NASH) is not known; guidelines from the American Association for the Study of Liver Diseases do not recommend surveillance imaging.
  • We sought to determine the prevalence of hepatocellular carcinoma among patients undergoing liver transplantation for NASH-related cirrhosis and their outcome after surgery, compared with controls.
  • METHODS: We reviewed the records of adult patients with NASH cirrhosis who underwent liver transplantation by using a prospectively collected database from a single center.
  • Data from patients with NASH cirrhosis were compared with matched controls who received transplantation for primary biliary cirrhosis/primary sclerosing cholangitis, alcoholic liver disease, or HCV.
  • RESULTS: Seventeen of 98 patients (17%) with NASH cirrhosis were diagnosed with hepatocellular carcinoma.
  • Six patients were diagnosed with hepatocellular carcinoma incidentally on explant.
  • Survival after liver transplantation was 88% after mean follow-up of 2.5 years.
  • The number of NASH patients known to have hepatocellular carcinoma before liver transplantation was greater than the number of patients with primary biliary cirrhosis/primary sclerosing cholangitis and comparable to the number of patients with alcoholic liver disease and HCV.
  • CONCLUSIONS: Patients with NASH cirrhosis are at risk for developing hepatocellular carcinoma; patients with NASH cirrhosis, especially men older than 50 years, should undergo surveillance imaging.
  • Patients with NASH and hepatocellular carcinoma have good outcomes after liver transplantation.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Carcinoma, Hepatocellular / surgery. Fatty Liver / complications. Fatty Liver / epidemiology. Liver Transplantation
  • [MeSH-minor] Adult. Age Factors. Aged. Case-Control Studies. Female. Humans. Male. Middle Aged. Risk Factors. Sex Factors. Survival Analysis. Treatment Outcome. United States

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  • [CommentIn] Liver Transpl. 2009 Oct;15(10):1367-8 [19806686.001]
  • (PMID = 19281869.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Achneck HE, Pradhan SK, Kavic SM, Longo WE: Primary signet-ring cell carcinoma mimicking segmental Crohn's colitis. Dig Liver Dis; 2005 Jul;37(7):537-41
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  • [Title] Primary signet-ring cell carcinoma mimicking segmental Crohn's colitis.
  • Primary signet-ring cell carcinoma of the colon is a rare entity with a dismal prognosis, mainly due to a delay in diagnosis.
  • A subsequent biopsy revealed poorly differentiated signet-ring cell carcinoma of the colon.
  • She was treated surgically with a left hemi-colectomy and primary repair.
  • A high degree of suspicion is necessary to correctly diagnose these, often young, patients with primary signet-ring cell carcinoma early and have a positive impact on survival.
  • The literature on primary signet-ring cell carcinoma is reviewed.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Colonic Neoplasms / diagnosis. Crohn Disease / diagnosis
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Barium Sulfate. Colectomy. Colonoscopy. Enema. Female. Humans. Recurrence

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  • (PMID = 15975543.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 25BB7EKE2E / Barium Sulfate
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43. Morise Z, Sugioka A, Fujita J, Hoshimoto S, Kato T, Ikeda M: S-1 plus cisplatin combination therapy for the patients with primary liver carcinomas. Hepatogastroenterology; 2007 Dec;54(80):2315-8
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  • [Title] S-1 plus cisplatin combination therapy for the patients with primary liver carcinomas.
  • BACKGROUND/AIMS: 5-FU plus Cisplatin combination therapy had been employed against primary liver carcinomas for years.
  • We herein examined the effect and adverse effects of S-1 plus Cisplatin combination therapy for primary liver carcinomas.
  • METHODOLOGY: 4 patients with hepatocellular carcinoma (HCC) and 3 with cholangiocellular carcinoma (CCC) were employed for this study.
  • They all had far-advanced diseases in and/or out of the liver at the time of the therapy initiation.
  • CONCLUSIONS: S-1 plus Cisplatin combination therapy is a potential therapy for advanced primary liver carcinomas.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Liver Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Drug Combinations. Female. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Oxonic Acid / administration & dosage. Prognosis. Tegafur / administration & dosage. Tomography, X-Ray Computed

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  • (PMID = 18265655.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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44. Bao ST, Gui SQ, Lin MS: Relationship between expression of Smac and Survivin and apoptosis of primary hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int; 2006 Nov;5(4):580-3
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  • [Title] Relationship between expression of Smac and Survivin and apoptosis of primary hepatocellular carcinoma.
  • However, little is known about the clinical significance of Smac/DIABLO in various cancers including hepatocellular carcinoma (HCC).
  • This study was undertaken to investigate the expression of Smac and Survivin and their relationship with the apoptosis in primary HCC.
  • The mRNA expression of Smac and Survivin was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) in HCC tissues of 50 patients, para-carcinoma tissues of 20 patients, and normal liver tissues of 15 patients.
  • RESULTS: Smac mRNA was detected by RT-PCR in HCC tissues of 21 (42.0%) of the 50 patients, para-carcinoma tissues of 19 (95.0%) of the 20 patients, and normal liver tissues of 15 (100%) of the 15 patients.
  • Survivin mRNA was found in HCC tissues of 46 of the 50 patients, para-carcinoma tissues of 2 of the 20 patients, and normal liver tissues of 0 of 15 patients.
  • Immunohistochemistry revealed Smac protein in HCC tissues of 20 patients (40.0%), in para-carcinoma tissues of 18 patients (90.0%), and normal liver tissues of 15 patients (100.0%).
  • Survivin protein was found in HCC tissues in 45 patients, para-carcinoma tissues in 2 patients, and normal liver tissues in none of the patients.
  • [MeSH-major] Apoptosis / physiology. Carcinoma, Hepatocellular / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Liver Neoplasms / metabolism. Microtubule-Associated Proteins / metabolism. Mitochondrial Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Liver / metabolism. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17085346.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / DIABLO protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Microtubule-Associated Proteins; 0 / Mitochondrial Proteins; 0 / Neoplasm Proteins
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45. Huang YQ, Xu F, Yang JM, Huang B: Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. Hepatobiliary Pancreat Dis Int; 2010 Feb;9(1):44-8
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  • [Title] Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases.
  • BACKGROUND: Primary hepatic neuroendocrine carcinoma (PHNEC) is extremely rare, and fewer than 300 cases have been reported in the English/Chinese-language literature, therefore it is difficult to make a proper diagnosis and determine a therapeutic approach.
  • All patients received liver resection.
  • CONCLUSIONS: Since PHNEC is easy to confuse with hepatocellular carcinoma, careful screening of symptoms is needed to avoid misdiagnosis.
  • [MeSH-major] Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy
  • [MeSH-minor] Adult. Carcinoma, Hepatocellular / diagnosis. Chemoembolization, Therapeutic. Diagnosis, Differential. Ethanol / administration & dosage. Ethanol / therapeutic use. Female. Humans. Injections. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / therapy. Positron-Emission Tomography. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20133228.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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46. Deutsch M, Papatheodoridis GV, Tzakou A, Hadziyannis SJ: Risk of hepatocellular carcinoma and extrahepatic malignancies in primary biliary cirrhosis. Eur J Gastroenterol Hepatol; 2008 Jan;20(1):5-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of hepatocellular carcinoma and extrahepatic malignancies in primary biliary cirrhosis.
  • OBJECTIVES: In primary biliary cirrhosis (PBC), the development of hepatocellular carcinoma (HCC) was thought to represent a rare complication.
  • The risk of extrahepatic malignancies is higher than that of HCC, but it is not influenced by the histologic stage of the liver disease.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Liver Cirrhosis, Biliary / complications. Liver Neoplasms / etiology
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / etiology. Cohort Studies. Disease Progression. Female. Follow-Up Studies. Genital Neoplasms, Female / etiology. Greece / epidemiology. Humans. Incidence. Male. Middle Aged. Retrospective Studies. Risk Factors

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  • [CommentIn] Eur J Gastroenterol Hepatol. 2008 Jan;20(1):1-4 [18090981.001]
  • (PMID = 18090982.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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47. Nan KJ, Guo H, Ruan ZP, Jing Z, Liu SX: Expression of p57(kip2) and its relationship with clinicopathology, PCNA and p53 in primary hepatocellular carcinoma. World J Gastroenterol; 2005 Feb 28;11(8):1237-40
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  • [Title] Expression of p57(kip2) and its relationship with clinicopathology, PCNA and p53 in primary hepatocellular carcinoma.
  • AIM: To investigate the expression of p57(kip2) and its relationship with clinicopathology, PCNA and p53 in primary hepatocellular carcinoma (HCC).
  • METHODS: Expression of p57(kip2), PCNA and p53 in tumor tissues from 32 patients with HCC and 10 liver tissues of normal persons was detected with Elivision immunohistochemical technique.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Liver Neoplasms / metabolism. Nuclear Proteins / metabolism. Proliferating Cell Nuclear Antigen / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adult. Aged. Apoptosis / physiology. Cyclin-Dependent Kinase Inhibitor p57. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15754413.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CDKN1C protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p57; 0 / Nuclear Proteins; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC4250722
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48. Hwang S, Lee SG, Moon DB, Ahn CS, Kim KH, Lee YJ, Ha TY, Song GW: Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma. Liver Transpl; 2007 May;13(5):741-6
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  • [Title] Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma.
  • Salvage liver transplantation has been performed for recurrent hepatocellular carcinoma (HCC) or deterioration of liver function after primary liver resection.
  • Because prior liver resection per se is an unfavorable condition for living donor liver transplantation (LDLT), we assessed the technical feasibility of LDLT after prior hepatectomy, and we compared the outcome of salvage LDLT with that of primary LDLT in HCC patients.
  • Of 342 patients with HCC, 17 (5%) underwent salvage LDLT, with 5 having undergone prior major liver resection and 12 prior minor resection.
  • Recipient operation time was not prolonged in patients undergoing salvage LDLT, but bleeding complications occurred more frequently than in patients undergoing primary LDLT.
  • Overall survival rates after salvage LDLT were similar to those after primary LDLT, especially when the extent of recurrent tumor was within the Milan criteria.
  • These results indicate that every combination of prior hepatectomy and living donor liver graft is feasible for patients undergoing salvage LDLT, and the acceptable extent of HCC for salvage LDLT is equivalent to that for primary LDLT.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatectomy. Liver Neoplasms / surgery. Liver Transplantation. Living Donors. Salvage Therapy
  • [MeSH-minor] Adult. Feasibility Studies. Female. Hemorrhage / etiology. Humans. Male. Middle Aged. Postoperative Complications. Reoperation

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  • [CommentIn] Liver Transpl. 2007 May;13(5):636-8 [17457856.001]
  • (PMID = 17457860.001).
  • [ISSN] 1527-6465
  • [Journal-full-title] Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • [ISO-abbreviation] Liver Transpl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Neff R, Abdel-Misih R, Khatri J, Dignazio M, Garcia M, Petrelli N, Wilson P: The toxicity of liver directed yttrium-90 microspheres in primary and metastatic liver tumors. Cancer Invest; 2008 Mar;26(2):173-7
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  • [Title] The toxicity of liver directed yttrium-90 microspheres in primary and metastatic liver tumors.
  • The yttrium-90 radiation dose was dependent upon the percentage of tumor involvement of the liver, with a dose modification (reduction) adjusted for macroaggregated albumin (MAA) shunted to the lung.
  • RESULTS: Twenty-one patients underwent twenty-five treatments with SIR microsphere therapy for primary and metastatic liver tumors.
  • CONCLUSIONS: The application of SIR microspheres has been utilized for a variety of liver tumors.
  • [MeSH-major] Carcinoma, Hepatocellular / radiotherapy. Liver Neoplasms / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Yttrium Radioisotopes / therapeutic use
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adenocarcinoma / secondary. Adult. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Breast Neoplasms / radiotherapy. Colorectal Neoplasms / pathology. Colorectal Neoplasms / radiotherapy. Female. Hepatic Artery / radiation effects. Humans. Male. Microspheres. Middle Aged. Neoplasm, Residual / radiotherapy. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / radiotherapy. Retrospective Studies. Survival Rate

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  • (PMID = 18259948.001).
  • [ISSN] 1532-4192
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Yttrium Radioisotopes
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50. Fujimoto Y, Nakanishi Y, Sekine S, Yoshimura K, Akasu T, Moriya Y, Shimoda T: CD10 expression in colorectal carcinoma correlates with liver metastasis. Dis Colon Rectum; 2005 Oct;48(10):1883-9
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  • [Title] CD10 expression in colorectal carcinoma correlates with liver metastasis.
  • PURPOSE: If it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis.
  • METHODS: From January 1995 to December 1997, 648 consecutive cases of colorectal carcinoma were recorded at the Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • We evaluated clinicopathologic and immunohistochemical factors (age, gender, tumor location, gross type, size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and expression of CD10, MUC2, and human gastric mucin) in 505 of these patients who had undergone resection of T2/T3/T4 colorectal carcinomas to clarify the correlation between these factors and liver metastasis.
  • RESULTS: Liver metastases, including unresectable, were detected in 122 patients (24 percent), all of whom had been followed for at least five years.
  • Univariate analysis revealed that liver metastasis was significantly associated with tumor size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and CD10 expression.
  • Multivariate analysis revealed that invasion deeper than the subserosa, venous invasion, lymph-node metastasis, and CD10 expression were significantly associated with liver metastases.
  • CONCLUSIONS: CD10 expression in colorectal carcinoma is a good predictor of liver metastasis.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Colorectal Neoplasms / chemistry. Liver Neoplasms / chemistry. Neprilysin / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Gastric Mucins / analysis. Humans. Male. Middle Aged. Mucin-2. Mucins / analysis. Neoplasm Metastasis. Predictive Value of Tests

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  • (PMID = 16175325.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gastric Mucins; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / Mucins; EC 3.4.24.11 / Neprilysin
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51. Lee HL, Liu YY, Yeh CN, Chiang KC, Chen TC, Jan YY: Primary squamous cell carcinoma of the liver: a successful surgically treated case. World J Gastroenterol; 2006 Sep 7;12(33):5419-21
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  • [Title] Primary squamous cell carcinoma of the liver: a successful surgically treated case.
  • Primary squamous cell carcinoma (SCC) of the liver is rare.
  • Primary SCC of the liver has been reported to be associated with hepatic teratoma, hepatic cyst, or hepatolithiasis.
  • Complete remission of poorly differentiated SCC of the liver could be achieved by systemic chemotherapy followed by surgery or remarkably respond to hepatic arterial injection of low dose chemotherapeutic drugs.
  • Here we report the first case of primary SCC of the liver presenting as a solid tumor and receiving successful hepatic resection with 9-mo disease free survival.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Humans. Liver / pathology. Liver / ultrasonography. Male. Remission Induction. Treatment Outcome. Ultrasonography

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  • (PMID = 16981283.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4088220
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52. Liang WC, Guo RP, Chen MS, Long H, Shi M, Wei W, Zhang YQ: [Efficacy of pulmonary resection for primary hepatocellular carcinoma patients with pulmonary metastasis]. Ai Zheng; 2008 Mar;27(3):319-22
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  • [Title] [Efficacy of pulmonary resection for primary hepatocellular carcinoma patients with pulmonary metastasis].
  • This study was to evaluate the efficacy of pulmonary resection for primary hepatocellular carcinoma (HCC) patients with pulmonary metastasis.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Pneumonectomy
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Survival Rate

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  • (PMID = 18334126.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Tischendorf JJ, Meier PN, Strassburg CP, Klempnauer J, Hecker H, Manns MP, Krüger M: Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis. Scand J Gastroenterol; 2006 Oct;41(10):1227-34
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  • [Title] Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis.
  • OBJECTIVE: Primary sclerosing cholangitis (PSC) confers a high risk of development of hepatobiliary carcinoma (HBC).
  • MATERIAL AND METHODS: Thirty-nine PSC patients with HBC at time of HBC diagnosis were compared with 101 PSC patients without HBC at time of acceptance for liver transplantation.
  • [MeSH-major] Biliary Tract Neoplasms / etiology. Cholangitis, Sclerosing / complications. Inflammatory Bowel Diseases / complications. Liver Neoplasms / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Biliary Tract Diseases / complications. Body Weight. CA-19-9 Antigen / analysis. Female. Humans. Male. Middle Aged. Risk Factors. Sex Factors. Smoking / adverse effects

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  • (PMID = 16990210.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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54. Lee KK, Kim DG, Moon IS, Lee MD, Park JH: Liver transplantation versus liver resection for the treatment of hepatocellular carcinoma. J Surg Oncol; 2010 Jan 1;101(1):47-53
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  • [Title] Liver transplantation versus liver resection for the treatment of hepatocellular carcinoma.
  • PURPOSE: Liver resection (LR) and liver transplantation (LT) are considered the only two potentially curative treatments for hepatocellular carcinoma (HCC).
  • HCC recurred more frequently after resection (51.5%) than it did after transplantation (29.5%) (P < 0.001), and HCC recurrence developed in the liver more frequently after LR than it did after LT (P = 0.002).
  • CONCLUSION: LT should be considered as the primary treatment in patients with HCC within the Milan criteria.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatectomy. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Survival Rate


55. Li SY, An P, Cai HY, Bai X, Zhang YN, Yu B, Zuo FY, Chen G: Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma. Hepatobiliary Pancreat Dis Int; 2010 Apr;9(2):149-53
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  • [Title] Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma.
  • BACKGROUND: Early diagnosis of liver metastasis of colorectal carcinoma is very important for the appropriate treatment of such patients.
  • The present study aimed to investigate the differential expression of proteins in patients with liver metastasis of colorectal carcinomas using proteomic analysis and evaluate its potentiality in clinical diagnosis.
  • METHODS: Fluorescence two-dimensional differential in-gel electrophoresis (2-D DIGE) was used to analyze and compare the protein expression between normal mucosa, the primary focus, and liver metastases.
  • Immunohistological staining was used to confirm the expression of differentially expressed proteins in colorectal carcinomas and areas of liver metastasis.
  • In 20 differentially expressed proteins, 3 were down-regulated and 17 up-regulated in liver metastases.
  • Proteomic analysis showed that the S-adenosylmethionine transgelin variant was down-regulated in liver metastasis tissues.
  • Zinc finger protein 64 homolog (Zfp64), guanine nucleotide exchange factor 4 (GEF4), human arginase, glutathione S-transferases (GSTs) A3, and tumor necrosis factor alpha (TNF-alpha)-induced protein 9 were up-regulated in liver metastasis tissues.
  • Immunohistochemical staining confirmed that human arginase expression was higher in liver metastases than in the primary focus.
  • CONCLUSIONS: There was a significant difference in protein expression between the primary focus of colorectal carcinoma and liver metastases.
  • The differentially regulated proteins were closely related to liver metastasis of colorectal carcinoma.
  • Elevated human arginase may be an important molecular marker for liver metastasis from colorectal carcinoma.
  • [MeSH-major] Colorectal Neoplasms / pathology. Liver Neoplasms / secondary. Neoplasm Proteins / analysis. Proteomics
  • [MeSH-minor] Adult. Aged. Electrophoresis, Gel, Two-Dimensional. Female. Humans. Immunohistochemistry. Male. Mass Spectrometry. Middle Aged

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  • (PMID = 20382585.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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56. D'Arrigo A, Belluco C, Ambrosi A, Digito M, Esposito G, Bertola A, Fabris M, Nofrate V, Mammano E, Leon A, Nitti D, Lise M: Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. Int J Cancer; 2005 Jun 10;115(2):256-62
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  • [Title] Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma.
  • Metastatic spread to the liver is the major contributor to mortality in patients with colorectal carcinoma (CRC).
  • In order to seek for gene expression patterns associated with metastatic potential in primary CRC, we compared the transcriptional profiles of 10 radically resected primary CRCs from patients who did not develop distant metastases within a 5-year follow-up period with those of 10 primary/metastatic tumor pairs from patients with synchronous liver metastases.
  • While a striking transcriptional similarity was observed between the primary tumors and their distant metastases, the nonmetastasizing primary tumors were clearly distinct from the primary/metastatic tumor pairs.
  • Of 37 gene expression differences found between the 2 groups of primary tumors, 29 also distinguished nonmetastasizing tumors from metastases.
  • The gene encoding for mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetyl-glucosaminyl-transferase (GnT-IV) became significantly upregulated in primary/metastatic tumor pairs (p < 0.001).
  • These data support the existence of a specific transcriptional signature distinguishing primary colon adenocarcinomas with different metastatic potential, the further pursuit of which may lead to relevant clinical and therapeutic applications.
  • [MeSH-minor] Adult. Aged. Female. Humans. Lasers. Male. Middle Aged. Neoplasm Staging. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. Transcription, Genetic

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 15688387.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.145 / alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase
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57. Kwon JE, Kim SH, Cho NH: No ancillary finding is valid to distinguish a primary ovarian hepatoid carcinoma from metastatic hepatocellular carcinoma. Int J Gynecol Cancer; 2006 Jul-Aug;16(4):1691-4
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  • [Title] No ancillary finding is valid to distinguish a primary ovarian hepatoid carcinoma from metastatic hepatocellular carcinoma.
  • Primary ovarian hepatoid carcinomas (POHC) are extremely rare.
  • Especially rare are those with phenotypic properties of hepatocellular carcinoma (HCC) and an absence of clinical evidence of hepatic tumor.
  • We report a case of a POHC with a common microscopic, immunophenotypic, and ultrastructural property of HCC in the absence of a liver mass.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. alpha-Fetoproteins / metabolism

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  • (PMID = 16884387.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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58. Choi BO, Jang HS, Kang KM, Lee SW, Kang YN, Chai GY, Choi IB: Fractionated stereotactic radiotherapy in patients with primary hepatocellular carcinoma. Jpn J Clin Oncol; 2006 Mar;36(3):154-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fractionated stereotactic radiotherapy in patients with primary hepatocellular carcinoma.
  • OBJECTIVE: The purpose of our study was to evaluate the feasibility and treatment outcomes of fractionated stereotactic radiotherapy (SRT) for primary hepatocellular carcinoma (HCC).
  • CONCLUSION: These results suggest that fractionated SRT is a relatively safe and effective method for treating small primary HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / radiotherapy. Dose Fractionation. Liver Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Feasibility Studies. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Remission Induction. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 16520355.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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59. Chen B, Gao L, Xu GZ, Li SY, Huang XD, Yi JL: [Postoperative radiotherapy for primary intraosseous carcinoma of the jaws]. Zhonghua Zhong Liu Za Zhi; 2007 Jul;29(7):540-4

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  • [Title] [Postoperative radiotherapy for primary intraosseous carcinoma of the jaws].
  • OBJECTIVE: To investigate the indication, location and dose of postoperative radiotherapy for primary intraosseous carcinoma (PIOC) of the jaws.
  • It seemed that surgery plus postoperative radiotherapy could not improve the survival of PIOC patients with involvement of adjacent soft-tissues or positive neck nodes or partial excision of primary tumor when compared with surgery alone, if the bias of selection in the patients for postoperative radiotherapy was neglected.
  • CONCLUSION: Postopreative radiotherapy may improve the survival for the patient with primary intraosseous carcinoma of the jaws.
  • Our suggestion is that postoperative radiotherapy should be applied to the patient with any of the following items: positive operative margin; tumor involvement of adjacent soft-tissues; positive neck nodes; partial excision of primary tumor.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Mandibular Neoplasms / radiotherapy. Maxillary Neoplasms / radiotherapy. Radiotherapy, High-Energy
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Mandible / surgery. Maxilla / surgery. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Radiotherapy, Adjuvant. Survival Rate. Young Adult

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  • (PMID = 18069638.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 8
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60. Ikegami T, Shimada M, Imura S, Yoshizumi T, Arakawa Y, Tokunaga T, Morine Y, Kanemura H: The timing of liver transplantation after primary hepatectomy for hepatocellular carcinoma: a special reference to recurrence pattern and Milan criteria. Transplantation; 2008 Sep 15;86(5):641-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The timing of liver transplantation after primary hepatectomy for hepatocellular carcinoma: a special reference to recurrence pattern and Milan criteria.
  • INTRODUCTION: Hepatic resection (HR) is commonly applied as first-line treatment of hepatocellular carcinoma (HCC) even in the era of liver transplantation (LT).
  • CONCLUSIONS: For HCCs not meeting Milan criteria, secondary LT after primary HR could be applied for a proportion of cases with less aggressiveness.
  • For those meeting Milan criteria, primary LT should be the first therapeutic option.
  • However, secondary LT could be offered for those with re-recurrence within criteria after primary HR.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatectomy / methods. Liver Neoplasms / surgery. Liver Transplantation / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Humans. Italy. Middle Aged. Patient Selection. Recurrence. Survival Analysis. Time Factors

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  • (PMID = 18791443.001).
  • [ISSN] 1534-6080
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Kirchner GI, Tischendorf JJ, Bleck J, Wagner S, Caselitz M, Klempnauer J, Manns MP, Gebel M: Perihilar lymph nodes in patients with primary sclerosing cholangitis with and without cholangiocellular carcinoma. Scand J Gastroenterol; 2008;43(11):1366-70
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  • [Title] Perihilar lymph nodes in patients with primary sclerosing cholangitis with and without cholangiocellular carcinoma.
  • OBJECTIVE: Enlarged perihilar lymph nodes have been described in patients with primary sclerosing cholangitis (PSC).
  • The aim of the study was to determine the clinical relevance of perihilar lymph nodes in PSC patients with and without cholangiocellular carcinoma (CCC).
  • Since perihilar lymph nodes are not predictive of the presence of complicating CCC, such patients should not be excluded from liver transplantation.
  • [MeSH-minor] Adult. Bile Ducts, Intrahepatic / ultrasonography. Female. Humans. Inflammatory Bowel Diseases / complications. Lymph Nodes / ultrasonography. Male. Middle Aged


62. Shah S, Gupta S, Shet T, Maheshwari A, Wuntkal R, Mohandas KM: Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary. Hepatobiliary Pancreat Dis Int; 2005 May;4(2):306-7
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  • [Title] Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary.
  • Metastatic clear cell carcinomas are commonly seen in the kidney and lung.
  • Clear cell variant of hepatocellular carcinoma is an uncommon tumour.
  • In this unusual case of metastatic clear cell carcinoma presenting as Sister Mary Joseph's nodule, no primary evidence was observed radiologically in the liver, but the level of alfa fetoprotein was markedly elevated.
  • Metastatic clear cell carcinoma of the liver with an occult hepatic primary was diagnosed by immunohistochemical profile of the tumour.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Neoplasms, Second Primary / pathology. alpha-Fetoproteins / analysis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 15908336.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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63. Lao Y: [Clinical study on effect of matrine injection to protect the liver function for patients with primary hepatic carcinoma after trans-artery chemo-embolization (TAE)]. Zhong Yao Cai; 2005 Jul;28(7):637-8
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  • [Title] [Clinical study on effect of matrine injection to protect the liver function for patients with primary hepatic carcinoma after trans-artery chemo-embolization (TAE)].
  • OBJECTIVE: To study effect of Matrine injection to prevent the liver function of patients with primary hepatic carcinoma (PHC) after trans-artery chemo-embolization.
  • CONCLUSIONS: Matrine injection may be used to protect the liver function for patients with PHC after TAE, to relieve the liver cells damage, and to improve the tolerance of TAE, so as to perform the next TAE in time.
  • [MeSH-major] Alkaloids / therapeutic use. Drugs, Chinese Herbal / therapeutic use. Liver / physiopathology. Liver Neoplasms / therapy. Phytotherapy. Plants, Medicinal / chemistry. Quinolizines / therapeutic use
  • [MeSH-minor] Adult. Aged. Chemoembolization, Therapeutic / methods. Female. Humans. Injections, Intravenous. Male. Middle Aged

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  • (PMID = 16252735.001).
  • [ISSN] 1001-4454
  • [Journal-full-title] Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  • [ISO-abbreviation] Zhong Yao Cai
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Drugs, Chinese Herbal; 0 / Quinolizines; 519-02-8 / matrine
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64. Man XB, Tang L, Zhang BH, Li SJ, Qiu XH, Wu MC, Wang HY: Upregulation of Glypican-3 expression in hepatocellular carcinoma but downregulation in cholangiocarcinoma indicates its differential diagnosis value in primary liver cancers. Liver Int; 2005 Oct;25(5):962-6
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  • [Title] Upregulation of Glypican-3 expression in hepatocellular carcinoma but downregulation in cholangiocarcinoma indicates its differential diagnosis value in primary liver cancers.
  • BACKGROUND/AIM: Expression alteration of Glypican-3 (GPC3) is associated with several malignancies and has been identified as an overexpressed gene in hepatocellular carcinoma (HCC).
  • The average expression level of GPC3 was significantly higher in HCC than that in adjacent liver tissues (P<0.0001).
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Carcinoma, Hepatocellular / metabolism. Cholangiocarcinoma / metabolism. Liver Neoplasms / metabolism. Membrane Proteins / genetics. Neoplasm Proteins / genetics
  • [MeSH-minor] Adult. Aged. Bile Ducts, Intrahepatic. Diagnosis, Differential. Female. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Glypicans. Humans. Male. Middle Aged

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  • (PMID = 16162153.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GPC3 protein, human; 0 / Glypicans; 0 / Membrane Proteins; 0 / Neoplasm Proteins
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65. Liang SX, Zhu XD, Xu ZY, Zhu J, Zhao JD, Lu HJ, Yang YL, Chen L, Wang AY, Fu XL, Jiang GL: Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance. Int J Radiat Oncol Biol Phys; 2006 Jun 1;65(2):426-34
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  • [Title] Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance.
  • PURPOSE: To identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation.
  • METHODS AND MATERIALS: The data of 109 primary liver carcinomas (PLC) treated with hypofractionated three-dimensional conformal radiation therapy (3D-CRT) were analyzed.
  • (1) Mean dose to normal liver (MDTNL) of 23 Gy was tolerable. (2) For cumulative dose-volume histogram, the tolerable volume percentages would be less than: V5 of 86%, V10 of 68%, V15 of 59%, V20 of 49%, V25 of 35%, V30 of 28%, V35 of 25%, and V40 of 20%. (3) Tolerable MDTNL could be estimated by MDTNL (Gy) = -1.686 + 0.023 * normal liver volume (cm3).
  • [MeSH-major] Liver / radiation effects. Liver Neoplasms / radiotherapy. Radiation Injuries / etiology. Radiation Tolerance / physiology. Radiotherapy, Conformal / adverse effects
  • [MeSH-minor] Adult. Aged. Carcinoma, Hepatocellular. Dose Fractionation. Female. Humans. Liver Cirrhosis / etiology. Liver Cirrhosis / pathology. Logistic Models. Male. Maximum Tolerated Dose. Middle Aged. Multivariate Analysis. Neoplasm Staging. ROC Curve. Risk Factors

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  • (PMID = 16690430.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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66. Fan ZH, Chen MH, Dai Y, Wang YB, Yan K, Wu W, Yang W, Yin SS: Evaluation of primary malignancies of the liver using contrast-enhanced sonography: correlation with pathology. AJR Am J Roentgenol; 2006 Jun;186(6):1512-9
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  • [Title] Evaluation of primary malignancies of the liver using contrast-enhanced sonography: correlation with pathology.
  • OBJECTIVE: Our purpose was to investigate the correlation of contrast-enhanced sonographic patterns with the histopathology of primary malignancies of the liver.
  • RESULTS: All 65 moderately to poorly differentiated hepatocellular carcinomas (HCCs) enhanced in the arterial phase, and 96.9% (63 lesions) of them quickly washed out in the portal venous phase.
  • Seventy-five percent of the clear cell carcinomas (12/16) enhanced in the arterial phase, 25% (4/16) did not enhance until the portal venous phase, and 31.3% (5/16) of the clear cell carcinomas washed out slowly during the late phase.
  • The enhancement and washout times of clear cell carcinomas were significantly different than those of moderately to poorly differentiated HCCs (p < 0.05).
  • CONCLUSION: Our study showed that the enhancement manifestations of primary malignancies of the liver are related to pathologic types and grades.
  • Contrast-enhanced sonograms may provide the histopathologic information for malignant tumors of the liver.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / ultrasonography. Contrast Media. Liver Neoplasms / pathology. Liver Neoplasms / ultrasonography. Phospholipids. Sulfur Hexafluoride
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged

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  • (PMID = 16714638.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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67. Abe K, Thung SN, Wu HC, Tran TT, Le Hoang P, Truong KD, Inui A, Jang JJ, Su IJ: Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children. Cancer Sci; 2009 Dec;100(12):2249-54
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  • Although many studies on the risk factors and their carcinogenesis in adult hepatocellular carcinoma (HCC) have been reported, they remain poorly understood in childhood HCC.
  • The HBV pre-S2 deletion mutant at nt 4-57 which has a CD8 T-cell epitope could be responsible for the emergence and aggressive outcome of childhood HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Gene Deletion. Hepatitis B Surface Antigens / genetics. Hepatitis B virus / genetics. Liver Neoplasms / etiology. Protein Precursors / genetics

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  • (PMID = 19719772.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hepatitis B Surface Antigens; 0 / Protein Precursors; 0 / presurface protein 2, hepatitis B surface antigen
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68. Scatton O, Liddo G, Belghiti J: Liver transplantation for hepatocellular carcinoma: current topics in France. J Hepatobiliary Pancreat Sci; 2010 Sep;17(5):567-73
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  • [Title] Liver transplantation for hepatocellular carcinoma: current topics in France.
  • BACKGROUND: Excellent survival obtained with liver transplantation (LT) for limited hepatocellular carcinoma (HCC) in patients with chronic liver disease is still challenged by the increasing discrepancy between candidates and grafts available.
  • RESULTS: Although the vast majority of cirrhotic patients with HCC are transplanted within the Milan criteria; the number of candidates is continually rising, while the number of grafts available is stable with a disappearance of adult LDLTs.
  • Moreover, the new rules for organ allocations, mainly based on the MELD score, minimize the accessibility to liver grafts for patients with HCC and compensated liver disease.
  • Moreover, the use of liver resection (LR) as a bridge therapy, showing that initial resection does not impair short- and long-term survival, led French surgeons to develop the concept of LR as a way to select patients who might benefit from LT and to use it, in selected cases, as a primary therapy, considering LT as salvage treatment in case of recurrence.
  • Moreover, the country of égalité is actually modifying the rules of graft attribution in order to reduce the inequality between the HCC patients with poor and good liver function.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. France / epidemiology. Humans. Incidence. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19760361.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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69. Silveira MG, Suzuki A, Lindor KD: Surveillance for hepatocellular carcinoma in patients with primary biliary cirrhosis. Hepatology; 2008 Oct;48(4):1149-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surveillance for hepatocellular carcinoma in patients with primary biliary cirrhosis.
  • Hepatocellular carcinoma (HCC) occurs with increased frequency in patients with primary biliary cirrhosis (PBC).
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / epidemiology. Liver Cirrhosis, Biliary / complications. Liver Neoplasms / diagnosis. Liver Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Female. Humans. Kaplan-Meier Estimate. Male. Mass Screening / methods. Middle Aged. Models, Theoretical. Prognosis. Retrospective Studies. Risk Factors. Severity of Illness Index. Treatment Outcome

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  • (PMID = 18785621.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Liu YM, Qin H, Wang CB, Fang XH, Ma QY: [Comparision of different interventional therapies for primary liver cancer]. Zhonghua Zhong Liu Za Zhi; 2007 Mar;29(3):232-5
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  • [Title] [Comparision of different interventional therapies for primary liver cancer].
  • OBJECTIVE: To investigate the efficacy of different interventional therapies for primary hepatic cell cancer (HCC).
  • The results of liver function, alpha-fetoprotein, imaging, color-ultrasonography and survival rate were reviewed.
  • The Child grade of liver function, color-ultrasonography and alpha-fetoprotein of TACE + RFA group, TACE and TAI were compared.
  • CONCLUSION: Compared with other modalities, transcatheter arterial chemoembolization (TACE) before or after hepatectomy is more effective than other interventional therapies for primary hepatocellular cancer, whereas, if combined with radiofrequency ablation (TAI), it is much more effective than TACE alone.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic / methods. Liver Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Catheter Ablation. Combined Modality Therapy. Female. Follow-Up Studies. Hepatectomy. Humans. Infusions, Intra-Arterial. Male. Middle Aged. Survival Analysis. Treatment Outcome. alpha-Fetoproteins / metabolism

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  • (PMID = 17649645.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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71. Arista-Nasr J, Fernández-Amador JA, Martínez-Benítez B, de Anda-González J, Bornstein-Quevedo L: Neuroendocrine metastatic tumors of the liver resembling hepatocellular carcinoma. Ann Hepatol; 2010 Apr-Jun;9(2):186-91
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  • [Title] Neuroendocrine metastatic tumors of the liver resembling hepatocellular carcinoma.
  • Certain neuroendocrine tumors (NET) metastasized to the liver can resemble hepatocellular carcinoma (HCC) in cytological needle biopsy.
  • From a total of 285 needle biopsies with primary or metastasized hepatic neoplasms, seven cases were selected originally diagnosed as HCC or HCC vs. NET metastasized to the liver.
  • Fourteen needle biopsies of hepatocellular carcinomas were also studied for comparative purposes.
  • In all of these neoplasms the diagnosis of endocrine tumor was confirmed by immunohistochemical studies and the following information was recorded: age, sex, radiological alterations, primary site of the NET, and follow-up.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver / pathology. Liver Neoplasms / secondary. Neuroendocrine Tumors / secondary
  • [MeSH-minor] Aged, 80 and over. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Mexico. Middle Aged. Predictive Value of Tests. Retrospective Studies. Young Adult

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  • (PMID = 20526014.001).
  • [ISSN] 1665-2681
  • [Journal-full-title] Annals of hepatology
  • [ISO-abbreviation] Ann Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Mexico
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72. Kinoshita Y, Tajiri T, Souzaki R, Tatsuta K, Higashi M, Izaki T, Takahashi Y, Taguchi T: Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. J Pediatr Hematol Oncol; 2008 Jun;30(6):447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study.
  • BACKGROUND AND PURPOSE: The serum alpha-fetoprotein (AFP) level has been used as a tumor marker for hepatoblastoma, and malignant germ cell tumors in pediatric patients.
  • The AFP has 3 isoforms (L1, L2, L3), and the usefulness of the L3 fraction as a diagnostic marker for the adult hepatocellular carcinoma is well known.
  • MATERIALS AND METHODS: From 2003 to 2006, two cases of hepatoblastoma, and 5 cases of germ cell tumor, all of which were neoinfantile, were treated in our department.
  • DISCUSSION: Our results indicated that the level of the L3 fraction accurately confirmed the existence, or the malignant potential of hepatic tumor or germ cell tumor.
  • [MeSH-major] Biomarkers, Tumor / blood. Hepatoblastoma / blood. Liver Neoplasms / blood. Neoplasms, Germ Cell and Embryonal / blood. alpha-Fetoproteins / analysis

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  • (PMID = 18525461.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Lectins; 0 / Protein Isoforms; 0 / alpha-Fetoproteins
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73. Ribeiro MA Jr, Rodrigues JJ, Habr-Gama A, Chaib E, D'Ipolitto G, Fonseca AZ, Saad WA Jr, Saad WA: Radiofrequency ablation of primary and metastatic liver tumors--4 years experience. Hepatogastroenterology; 2007 Jun;54(76):1170-5
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  • [Title] Radiofrequency ablation of primary and metastatic liver tumors--4 years experience.
  • BACKGROUND/AIMS: Radiofrequency ablation of primary and metastatic liver tumors has been shown to be one of the promising new modalities to treat or to palliate liver tumors.
  • It has been used as a bridge to liver transplantation as well as an approach to recurrent tumors after resection.
  • There were 32 cases of hepatocellular carcinoma, 35 metastases of colorectal cancer and 11 cases of other tumors.
  • All liver segments were compromised specially IV, VII, VIII.
  • CONCLUSIONS: The RFA procedure is safe, can be performed by different ways and in the group of patients who are candidates to liver transplantation, while waiting for the organ.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Catheter Ablation. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17629064.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Greece
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74. Tan SK, Qiu XQ, Yu HP, Zeng XY, Zhao YN, Hu L: [Evaluation of the risk of clonorchiasis inducing primary hepatocellular carcinoma]. Zhonghua Gan Zang Bing Za Zhi; 2008 Feb;16(2):114-6
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  • [Title] [Evaluation of the risk of clonorchiasis inducing primary hepatocellular carcinoma].
  • OBJECTIVE: To explore the relationship between clonorchiasis and primary hepatocellular carcinoma (HCC) and analyze the synergistic actions of HBV infection, alcohol consumption and clonorchiasis on HCC development.
  • [MeSH-major] Carcinoma, Hepatocellular / parasitology. Clonorchiasis. Liver Neoplasms / parasitology
  • [MeSH-minor] Adolescent. Adult. Aged. Animals. Case-Control Studies. Clonorchis sinensis / isolation & purification. Female. Humans. Male. Middle Aged. Prevalence. Risk Factors. Young Adult

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  • (PMID = 18304427.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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75. Suzuki A, Lymp J, Donlinger J, Mendes F, Angulo P, Lindor K: Clinical predictors for hepatocellular carcinoma in patients with primary biliary cirrhosis. Clin Gastroenterol Hepatol; 2007 Feb;5(2):259-64
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  • [Title] Clinical predictors for hepatocellular carcinoma in patients with primary biliary cirrhosis.
  • BACKGROUND & AIMS: Although hepatocellular carcinoma (HCC) occurs with increased frequency in patients with primary biliary cirrhosis (PBC), the exact frequency is relatively low.
  • [MeSH-major] Carcinoma, Hepatocellular / epidemiology. Liver Cirrhosis, Biliary / complications. Liver Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Factors. Aged. Blood Transfusion. Case-Control Studies. Female. Humans. Hypertension, Portal / etiology. Male. Middle Aged. Risk Factors. Sex Factors

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  • (PMID = 17174610.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Ryu HS, Hwang ET, Choi CS, Kim TH, Kim HC, Yun KJ, Park DE: [A case of hepatocellular carcinoma invading the gallbladder misdiagnosed as a primary gallbladder carcinoma]. Korean J Hepatol; 2009 Mar;15(1):80-4
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  • [Title] [A case of hepatocellular carcinoma invading the gallbladder misdiagnosed as a primary gallbladder carcinoma].
  • Extrahepatic metastasis of hepatocellular carcinoma (HCC) is occasionally seen in the lung, bone, adrenal gland, and lymph nodes.
  • Since there is no peritoneum between the gallbladder and the liver fossa, a gallbladder cancer easily invades the liver; however, HCC seldom invades the gallbladder because it rarely destroys the muscle layer or the collagen fibers of the gallbladder wall.
  • We report here a case of HCC that directly invaded the gallbladder, and that resembled gallbladder carcinoma invading the liver.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Gallbladder Neoplasms / secondary. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 19346788.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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77. Yasumoto T, Murakami T, Katsumoto Y, Hashimoto T, Noda S, Murata K, Kinuta M, Nakamura H: [Radiofrequency ablation for hepatocellular carcinoma and liver metastases]. Gan To Kagaku Ryoho; 2005 Oct;32(11):1596-9
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  • [Title] [Radiofrequency ablation for hepatocellular carcinoma and liver metastases].
  • We evaluated the efficacy of radiofrequency ablation (RFA) therapy for 29 patients with 36 hepatocellular carcinoma (HCC) nodules and 16 patients with 38 metastatic hepatic nodules.
  • The primary lesions of patients with metastatic liver tumors were 9 colon cancer, 2 rectal cancer, 2 breast cancer, 2 gastric cancer, and 1 esophageal cancer.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Catheter Ablation. Liver Neoplasms / secondary. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged

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  • (PMID = 16315881.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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78. Sun B, Luo M, Lu Z, Meng Y, Wu S, Wu M: Clinical studies of laser ablation in treatment of primary liver carcinoma-associated portal vein tumor thrombus. Clin Appl Thromb Hemost; 2010 Dec;16(6):694-7
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  • [Title] Clinical studies of laser ablation in treatment of primary liver carcinoma-associated portal vein tumor thrombus.
  • METHODS: A total of 43 male patients with primary liver carcinoma (PLC)-associated PVTT were randomized into a laser ablation group and a radiotherapy group.
  • [MeSH-major] Carcinoma, Hepatocellular / complications. Carcinoma, Hepatocellular / surgery. Laser Therapy / methods. Liver Neoplasms / complications. Liver Neoplasms / surgery. Venous Thrombosis / etiology. Venous Thrombosis / surgery
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Combined Modality Therapy. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Mitomycin / administration & dosage. Portal Vein / pathology. Portal Vein / surgery. Quality of Life. Radiotherapy, Conformal. Survival Analysis

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  • (PMID = 19833619.001).
  • [ISSN] 1938-2723
  • [Journal-full-title] Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
  • [ISO-abbreviation] Clin. Appl. Thromb. Hemost.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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79. Kasper HU, Drebber U, Stippel DL, Dienes HP, Gillessen A: Liver tumor infiltrating lymphocytes: comparison of hepatocellular and cholangiolar carcinoma. World J Gastroenterol; 2009 Oct 28;15(40):5053-7
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  • [Title] Liver tumor infiltrating lymphocytes: comparison of hepatocellular and cholangiolar carcinoma.
  • AIM: To investigate the role of tumor infiltrating lymphocytes (TIL) in primary hepatocellular and cholangiolar carcinomas of the liver.
  • METHODS: Immunohistochemical analysis was performed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-fixed and paraffin-embedded tissue of 35 liver resection specimens of hepatocellular or cholangiocellular carcinomas.
  • Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface.
  • RESULTS: All hepatocellular carcinomas showed infiltration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power fields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF).
  • There was no significant difference between hepatocellular or cholangiolar carcinoma.
  • CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells independent of histogenetic origin.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology. Lymphocytes, Tumor-Infiltrating / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immune System. Immunohistochemistry / methods. Lymphocyte Activation. Lymphocytes / cytology. Male. Middle Aged

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  • (PMID = 19859998.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2768884
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80. Li CX, Zhang Y, Gao L: [Analysis of combinated transcatheter hepatic artery chemoembolization and factors affecting the prognosis in patients with primary hepatic carcinoma]. Zhonghua Zhong Liu Za Zhi; 2006 Dec;28(12):942-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of combinated transcatheter hepatic artery chemoembolization and factors affecting the prognosis in patients with primary hepatic carcinoma].
  • OBJECTIVE: To evaluate the combinated transcatheter hepatic artery chemoembolization (TACE) and analyse the factors affecting prognosis in patients with primary hepatic carcinoma.
  • METHODS: 141 consecutive patients with primary hepatic carcinoma were treated, including 125 men and 16 women (mean age, 52 years; age range, 21 - 76 years).
  • The factors included sex, age, ALT, AFP, HBsAg, liver function (Child's system), the way of treatment, tumor size and number, serum albumin, portal cancerous thrombus, pathological type of tumors, and HBeAg.
  • Multivariable analysis revealed significant prognostic factors as follows: age, liver function, the way of treatment, portal cancerous thrombus and pathological types of tumors (chi2 = 45.993, P = 0.0001).
  • In this study, 5 factors directly influencing the prognosis are age, liver function, portal cancerous thrombus and pathological types of tumors are risk prognostic factors, and the way of treatment is a protective factor (chi2 = 45.993, chi2 = 0.0001).
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic. Liver Neoplasms / therapy
  • [MeSH-minor] Acetaldehyde / administration & dosage. Adult. Age Factors. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy / statistics & numerical data. Female. Follow-Up Studies. Hepatectomy / methods. Humans. Infusions, Intra-Arterial. Injections, Intradermal. Male. Middle Aged. Neoplastic Cells, Circulating / pathology. Portal Vein. Prognosis. Proportional Hazards Models. Survival Analysis

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  • (PMID = 17533749.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] GO1N1ZPR3B / Acetaldehyde
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81. Yan LN, Chen XL, Li ZH, Li B, Lu SC, Wen TF, Zeng Y, Yiao HH, Yang JY, Wang WT, Xu MQ: Perioperative management of primary liver cancer. World J Gastroenterol; 2007 Apr 7;13(13):1970-4
MedlinePlus Health Information. consumer health - Liver Cancer.

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  • [Title] Perioperative management of primary liver cancer.
  • AIM: To minimize the complications and mortality and improve the survival in primary liver cancer (PLC) patients undergoing hepatic resection.
  • The half liver vascular occlusion protocol (n = 523) versus the Pringle method (n = 476) showed that the former significantly reduced the postoperative complications (25.8% vs 11.9%) and mortality (2.3% vs 0.6%) respectively, and cut mean hospital stay was 3.5 d.
  • CONCLUSION: RTI is of value in predicting hepatic functional reserve, half liver occlusion could protect the residual liver function, and AKBR measurement is a simple and accurate means of assessing the state of postoperative metabolism.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / surgery. Liver Neoplasms / surgery. Perioperative Care / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Energy Metabolism / physiology. Female. Humans. Ketone Bodies / blood. Liver / metabolism. Liver / physiopathology. Liver / surgery. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17461499.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ketone Bodies
  • [Other-IDs] NLM/ PMC4146975
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82. Takada Y, Uemoto S: Liver transplantation for hepatocellular carcinoma: the Kyoto experience. J Hepatobiliary Pancreat Sci; 2010 Sep;17(5):527-32
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  • [Title] Liver transplantation for hepatocellular carcinoma: the Kyoto experience.
  • BACKGROUND/PURPOSE: The results of living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) at Kyoto University were analyzed.
  • Survival rates did not differ between pretreated and primary groups, and recurrence rates were similarly low when limited to patients who met the Kyoto criteria.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery. Liver Transplantation / methods
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hospitals, University. Humans. Incidence. Japan / epidemiology. Living Donors. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome. Young Adult


83. Treska V, Skalický T, Sutnar A, Liska V, Ferda J, Mírka H, Slauf F, Duras P, Kreuzberg B: [Portal vein branch embolization in patients with primary inoperable liver tumors]. Rozhl Chir; 2010 Sep;89(9):456-60
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  • [Title] [Portal vein branch embolization in patients with primary inoperable liver tumors].
  • INTRODUCTION: Portal vein embolization (PVE) is indicated in patients with insufficient liver remnants following liver resections for tumor disorders.
  • Therefore, due to PVE, the number of primary operable patients is higher.
  • Insufficient growth of the liver parenchyma or malignant progression remain the PVE cons.
  • METHODS: 40 patients (35 with colorectal carcinoma metastases, 2 with breast carcinoma metastases and one with ovarian carcinoma metastases, 2 with hepatocellular carcinoma) were indicated for PVE due to insufficient liver reserve following planned liver resection.
  • RESULTS: Liver resections were completed in 22 subjects, 42.6 days (mean value) after PVE.
  • In 14 (35%) subjects, the liver resection could not be performed (11x tumor progression, 3x insufficient liver tissue growth).
  • CONCLUSION: PVE has become an established procedure in stage liver procedures, due to its potential to facilitate operability of primary and secondary liver tumors.
  • In order to improve the outcomes, attention must be paid to the post- PVE growth of the liver parenchyma and further assessment of oncological treatment approaches during the pre- and post- PVE period, with the aim to reduce liver and extra-liver malignant progression rates prior to the liver resection procedure.
  • [MeSH-major] Embolization, Therapeutic. Liver Neoplasms / therapy. Portal Vein
  • [MeSH-minor] Adult. Aged. Cone-Beam Computed Tomography. Female. Hepatectomy. Humans. Liver / pathology. Liver / radiography. Liver Function Tests. Male. Middle Aged. Survival Rate

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  • (PMID = 21121156.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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84. Huang JH, Wu PH, Gu YK, Zhang FJ, Li CX, Gao F, Zhang L, Fan WJ, Li CJ: [Study on primary hepatocellular carcinoma associated with hypersplenism treated by partial splenic embolization combined with hepatic arterial chemoembolization]. Ai Zheng; 2006 Aug;25(8):1003-6
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  • [Title] [Study on primary hepatocellular carcinoma associated with hypersplenism treated by partial splenic embolization combined with hepatic arterial chemoembolization].
  • BACKGROUND & OBJECTIVE: 70-90% of patients of primary hepatocellular carcinoma (PHC) are associated with liver cirrhosis, portal hypertension and hypersplenism.
  • The treatment of PHC is usually hampered by low or slow recovery of blood cell counts.
  • RESULTS: Satisfactory effects were achieved in PSE combined with TACE group in terms of correction of blood cell counts compared with cases treated with TACE alone.
  • CONCLUSION: PSE associated with TACE is safe and effective for the treatment of patients with PHC associated with liver cirrhosis, portal hypertension and hypersplenism.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic. Hypersplenism / therapy. Liver Neoplasms / therapy
  • [MeSH-minor] Adult. Blood Cell Count. Embolization, Therapeutic / methods. Female. Hepatic Artery. Humans. Iodized Oil. Male. Splenic Artery

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  • (PMID = 16965683.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 8001-40-9 / Iodized Oil
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85. Somorácz A, Tátrai P, Horváth G, Kiss A, Kupcsulik P, Kovalszky I, Schaff Z: Agrin immunohistochemistry facilitates the determination of primary versus metastatic origin of liver carcinomas. Hum Pathol; 2010 Sep;41(9):1310-9
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  • [Title] Agrin immunohistochemistry facilitates the determination of primary versus metastatic origin of liver carcinomas.
  • In our earlier work, we demonstrated that agrin, a multifunctional heparan sulfate proteoglycan, accumulates in hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC).
  • Here, we have examined the expression of agrin in metastatic liver carcinomas in comparison with primary liver tumors.
  • Immunohistochemistry for agrin was performed on 25 HCC, 16 intrahepatic CCC, 20 colorectal cancer metastasis (CRCm), and 18 pancreatic ductal carcinoma metastasis (PDCm) samples and evaluated with both quantitative and qualitative methods.
  • Agrin mRNA expression was measured in 11 HCC, 7 CCC, 11 CRCm, and 12 normal liver tissues.
  • As opposed to HCC, agrin immunostaining was faint or nearly absent from the CD34-positive microvessels of CCC, CRCm, and PDCm; rather, it was detected in the basement membranes surrounding tumor cell pseudoglandules.
  • Thus, agrin immunohistochemistry may facilitate determination of primary versus metastatic origin in problematic liver cancer cases.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Agrin / metabolism. Carcinoma, Hepatocellular / pathology. Colorectal Neoplasms / secondary. Liver Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / metabolism. Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Carcinoma, Pancreatic Ductal / genetics. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / secondary. Cholangiocarcinoma / genetics. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. DNA, Neoplasm / analysis. Diagnosis, Differential. Endothelium, Vascular / metabolism. Endothelium, Vascular / pathology. Female. Gene Expression Regulation, Neoplastic. Hepatectomy. Humans. Male. Microvessels / metabolism. Microvessels / pathology. Middle Aged. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. RNA, Messenger / metabolism. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20471664.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Agrin; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / RNA, Messenger
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86. Homayounfar K, Gunawan B, Cameron S, Haller F, Baumhoer D, Uecker S, Sander B, Ramadori G, Lorf T, Füzesi L: Pattern of chromosomal aberrations in primary liver cancers identified by comparative genomic hybridization. Hum Pathol; 2009 Jun;40(6):834-42
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  • [Title] Pattern of chromosomal aberrations in primary liver cancers identified by comparative genomic hybridization.
  • Little is known about the molecular cytogenetic changes in cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma, and on the prognostic significance of chromosomal imbalances in hepatocellular carcinoma.
  • Seventy-eight cases of primary liver cancer with available median follow-up of 16.5 months, including 49 hepatocellular carcinomas, 22 cholangiocarcinomas, and 7 combined hepatocellular-cholangiocarcinomas, were examined by comparative genomic hybridization.
  • In hepatocellular carcinoma, the most frequent changes were +8q (54%), -8p (54%), and +1q (42%), followed by -6q (35%), -4q (33%), -13q (29%), -14q (25%), -16q (19%), -17p (19%), +17q (17%), and +20q (15%).
  • In comparison, cholangiocarcinoma had more gains, losses, and breakpoints than hepatocellular carcinoma or combined hepatocellular-cholangiocarcinoma, specifically more frequently -6q (91%), -3p (68%), -9p (55%), -14q (55%), -13q (45%), +1q (41%), +7q (36%), +7p (32%), and +8q (32%).
  • In contrast, combined hepatocellular-cholangiocarcinoma shared frequent +1q (71%), +8q (57%), and -8p (57%) with hepatocellular carcinoma, but a tendency for higher numbers of imbalances with cholangiocarcinoma.
  • Overall, higher numbers of changes, breakpoints, or gains appeared to carry unfavorable prognostic value among hepatocellular carcinomas, with higher numbers of gains retaining prognostic value among R0-resected hepatocellular carcinomas.
  • On the other hand, combined hepatocellular-cholangiocarcinoma may share similar chromosomal changes with both hepatocellular carcinoma and cholangiocarcinoma, as reflected by common hepatocellular carcinoma-like +8q, +1q, and -8p and a tendency for cholangiocarcinoma-like chromosomal instability.
  • In hepatocellular carcinoma, higher number of gains may prove an adverse prognostic parameter.
  • [MeSH-major] Chromosome Aberrations. Liver Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / genetics. Cholangiocarcinoma / pathology. Comparative Genomic Hybridization. Female. Humans. Male. Middle Aged

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  • (PMID = 19200581.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Zhu Lz, Yang Rj: [Digital subtraction angiography manifestation and interventional therapy of arteriovenous shunting in primary hepatocellular carcinoma of advanced stage]. Beijing Da Xue Xue Bao; 2008 Apr;40(2):129-34
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  • [Title] [Digital subtraction angiography manifestation and interventional therapy of arteriovenous shunting in primary hepatocellular carcinoma of advanced stage].
  • OBJECTIVE: To explore the appearances of digital subtraction angiography (DSA) and therapeutic efficacy of interventional therapy of hepatic carcinoma accompanied with arteriovenous shunting (AVS).
  • METHODS: To retrospectively analyze clinical material of 97 patients with hepatocellular carcinoma with hepatic artery-portal vein shunting(HA-PVS), of whom, 16 had upper gastrointestinal hemorrhage, 51 had middle to large amounts of ascites, and 53 had varices of esophagus and fundus gastricus.
  • CONCLUSION: Primary hepatic carcinoma with AVS increases difficulty of interventional therapyìbut as long as we take active and proper treating measureìwe could acquire satisfactory curative effect without serious syndrome.
  • DSA can demonstrate the type, the site and the degree of AVS completely and directly, thus having important value in treating primary hepatic carcinoma and improving prognosis.
  • [MeSH-major] Angiography, Digital Subtraction. Arteriovenous Fistula / radiography. Arteriovenous Fistula / therapy. Chemoembolization, Therapeutic / methods. Liver Neoplasms / radiography
  • [MeSH-minor] Adult. Aged. Carcinoma, Hepatocellular / complications. Carcinoma, Hepatocellular / radiography. Female. Hepatic Artery / abnormalities. Humans. Male. Middle Aged. Portal Vein / abnormalities. Retrospective Studies

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  • (PMID = 18458684.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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88. Granov DA, Ten VP, Rasskazov AK, Pozharskiĭ KM: [Angiogenetic features in liver carcinoma and their prognostic value: clinical and immunohistochemical study]. Arkh Patol; 2006 Nov-Dec;68(6):6-10
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  • [Title] [Angiogenetic features in liver carcinoma and their prognostic value: clinical and immunohistochemical study].
  • Survival rates were studied in 57 patients with primary liver carcinoma (including 32 with hepatocellular carcinoma [HCC] and 25 with cholangiocellular carcinoma [CCC] in relation to the histological type of a tumor and its microcirculatory bed.
  • In all the patients, tumor resection was performed, followed by chemoemlolization of the liver.
  • [MeSH-major] Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Liver Neoplasms / mortality. Liver Neoplasms / pathology. Neovascularization, Pathologic / mortality. Neovascularization, Pathologic / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17290884.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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89. Yu L, Sloane DA, Guo C, Howell CD: Risk factors for primary hepatocellular carcinoma in black and white Americans in 2000. Clin Gastroenterol Hepatol; 2006 Mar;4(3):355-60
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  • [Title] Risk factors for primary hepatocellular carcinoma in black and white Americans in 2000.
  • BACKGROUND & AIMS: The incidence of primary hepatocellular carcinoma (HCC) is greater in black Americans compared with white Americans.
  • There was no racial difference in the frequency of alcoholic and cryptogenic liver diseases and diabetes.
  • [MeSH-major] African Americans. Carcinoma, Hepatocellular / ethnology. Carcinoma, Hepatocellular / etiology. European Continental Ancestry Group. Liver Neoplasms / ethnology. Liver Neoplasms / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Prevalence. Risk Factors. United States / epidemiology

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  • (PMID = 16527700.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Liang SN, Liu LL, Su HY, Feng B, Zhao GS, Xu K: [Analysis of severe complications after transcatheter arterial chemoembolization for primary hepatocellular carcinoma]. Zhonghua Zhong Liu Za Zhi; 2008 Oct;30(10):790-2
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  • [Title] [Analysis of severe complications after transcatheter arterial chemoembolization for primary hepatocellular carcinoma].
  • OBJECTIVE: To investigate the cause and treatment as well as prevention measures of rarely occurring severe complications after transcatheter arterial chemoembolization (TACE) for primary hepatic carcinoma.
  • METHODS: 573 consecutive patients with primary hepatic carcinoma underwent a total of 1252 TACE procedures from January 2005 to July 2007.
  • CONCLUSION: The rarely occurring severe complications after transcatheter arterial chemoembolization for primary hepatic carcinoma is correlated with poor hepatic function and portal hypertension before therapy, overdose and reflux of chemotherapeutic agents or allotopic chemoembolism, etc.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic / methods. Gastrointestinal Hemorrhage / etiology. Liver Failure / etiology. Liver Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Epirubicin / administration & dosage. Epirubicin / adverse effects. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Hepatic Encephalopathy / etiology. Humans. Iodized Oil / administration & dosage. Iodized Oil / adverse effects. Male. Middle Aged. Mitomycin / administration & dosage. Mitomycin / adverse effects. Pulmonary Embolism / etiology. Young Adult

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  • (PMID = 19173817.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 3Z8479ZZ5X / Epirubicin; 50SG953SK6 / Mitomycin; 8001-40-9 / Iodized Oil; U3P01618RT / Fluorouracil
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91. Xu J, Chen X: Expression of twist gene in primary liver cancer. J Huazhong Univ Sci Technolog Med Sci; 2007 Dec;27(6):668-70
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  • [Title] Expression of twist gene in primary liver cancer.
  • In order to investigate the possibility of overexpression of Twist in primary liver cancer (PLC), the Twist expression was detected by using immunohistochemical analysis and RT-PCR assay in 45 patients with PLC.
  • Control tissues were obtained from 9 patients with liver hemangioma.
  • In noncancerous adjacent areas and control liver tissues, the expression of Twist was 57.8% and 22.2% respectively.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Liver Neoplasms / genetics. Nuclear Proteins / genetics. Twist Transcription Factor / genetics
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation. Young Adult

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  • (PMID = 18231738.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / TWIST1 protein, human; 0 / Twist Transcription Factor
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92. Tezuka M, Hayashi K, Kubota K, Sekine S, Okada Y, Ina H, Irie T: Growth rate of locally recurrent hepatocellular carcinoma after transcatheter arterial chemoembolization: comparing the growth rate of locally recurrent tumor with that of primary hepatocellular carcinoma. Dig Dis Sci; 2007 Mar;52(3):783-8
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  • [Title] Growth rate of locally recurrent hepatocellular carcinoma after transcatheter arterial chemoembolization: comparing the growth rate of locally recurrent tumor with that of primary hepatocellular carcinoma.
  • We compared the growth rate of locally recurrent hepatocellular carcinoma (HCC) with that of primary HCC.
  • The tumor volume doubling time (DT) of locally recurrent HCC was significantly shorter than that of primary HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bromhexine. Chemoembolization, Therapeutic. Female. Humans. Male. Middle Aged. Radiographic Image Enhancement

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  • (PMID = 17268830.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q1J152VB1P / Bromhexine
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93. Obed A, Tsui TY, Schnitzbauer AA, Obed M, Schlitt HJ, Becker H, Lorf T: Liver transplantation as curative approach for advanced hepatocellular carcinoma: is it justified? Langenbecks Arch Surg; 2008 Mar;393(2):141-7
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  • [Title] Liver transplantation as curative approach for advanced hepatocellular carcinoma: is it justified?
  • BACKGROUND: Liver transplantation is considered as one of therapeutic approaches to hepatocellular carcinoma (HCC).
  • Patients were treated either with primary tumour resection, transarterial chemoembolisation (TACE) or liver transplantation (LTx) by an interdisciplinary team.
  • RESULTS: The overall 1-year and 5-year survivals of patients in LTx group were 95 and 57%, respectively, which were significantly higher than those in primary tumour resection group (65 and 33%, P < 0.01) and those in TACE group (44 and 4%, P < 0.01).
  • In parallel, 1-year and 5-year tumour-free survivals of patients in LTx group (75 and 62%) were significantly higher than those in primary tumour resection group (50 and 11%, P < 0.01).
  • There were no significant differences in 1- and 5-year survivals of patients with early tumour stage received LTx or primary tumour resection, whereas patients in advanced tumour stage based on pathological findings of explanted liver significantly benefited from LTx as compared to primary resection.

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  • (PMID = 18043937.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3085731
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94. Kim BW, Park YK, Kim YB, Wang HJ, Kim MW: Salvage liver transplantation for recurrent hepatocellular carcinoma after liver resection: feasibility of the Milan criteria and operative risk. Transplant Proc; 2008 Dec;40(10):3558-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salvage liver transplantation for recurrent hepatocellular carcinoma after liver resection: feasibility of the Milan criteria and operative risk.
  • INTRODUCTION: Although the Milan criteria are widely accepted for liver transplantation (OLT) for hepatocellular carcinoma (HCC), they have not been fully evaluated as feasible for salvage liver transplantation (SLT) of recurrent HCC after hepatic resection.
  • PATIENTS AND METHODS: From March 2005 to November 2007, 46 HCC patients received OLT including 15 SLTs after prior partial hepatectomy (SLT group) and 31 primary OLTs (PLT group).
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery. Liver Transplantation / methods. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Adult. Feasibility Studies. Female. Humans. Male. Middle Aged. Patient Selection. Postoperative Complications / epidemiology. Retrospective Studies. Risk Factors. Salvage Therapy / methods

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  • (PMID = 19100437.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Zhan XK, Sun YK, Zhang W, Wang JW: [Clinical analysis of 81 cases with primary small cell carcinoma of the esophagus]. Zhonghua Zhong Liu Za Zhi; 2008 Dec;30(12):926-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 81 cases with primary small cell carcinoma of the esophagus].
  • OBJECTIVE: To evaluate the clinical characteristics, treatment and prognostic factors in patients with primary small cell carcinoma (SmCC) of the esophagus.
  • CONCLUSION: Esophageal small cell carcinoma is a rare but highly aggressive malignant tumor.
  • [MeSH-major] Carcinoma, Small Cell / therapy. Esophageal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / therapeutic use. Combined Modality Therapy. Esophagectomy. Etoposide / therapeutic use. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Neoplastic Cells, Circulating. Proportional Hazards Models. Retrospective Studies. Survival Rate

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  • (PMID = 19173995.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; JET protocol
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96. Tan SK, Qiu XQ, Yu HP, Zeng XY, Xiao ZM, Hu L: [Etiologic fraction and interaction of risk factors for primary hepatic carcinoma in Guangxi, China]. Zhonghua Yu Fang Yi Xue Za Zhi; 2008 Mar;42(3):169-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Etiologic fraction and interaction of risk factors for primary hepatic carcinoma in Guangxi, China].
  • OBJECTIVE: To explore etiologic fraction (EF) and interaction of hepatitis B virus (HBV) infection and other risk factors for primary hepatocellular carcinoma (PHC) in Guangxi, China.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Liver Neoplasms / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. China / epidemiology. Data Interpretation, Statistical. Female. Humans. Male. Middle Aged. Risk Factors

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  • (PMID = 18788580.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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97. Chen WJ, Kuo JY, Chen KK, Lin AT, Chang YH, Chang LS: Primary urothelial carcinoma of the ureter: 11-year experience in Taipei Veterans General Hospital. J Chin Med Assoc; 2005 Nov;68(11):522-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary urothelial carcinoma of the ureter: 11-year experience in Taipei Veterans General Hospital.
  • BACKGROUND: Urothelial carcinoma of the upper urinary tract is relatively rare, occurring in 5% of all urothelial tumors.
  • Ureteral urothelial carcinoma is even less common than that of the renal pelvis, accounting for about 25% of all upper urinary tract tumors.
  • The aim of this study was to evaluate the clinical behavior, survival, recurrence and prognostic information of primary ureteral urothelial carcinoma from our 11 years of experience at the Taipei Veterans General Hospital.
  • METHODS: We retrospectively reviewed 111 patients with ureteral urothelial carcinoma who had been treated in our hospital between January 1993 and December 2003.
  • Disease recurrence in the nephroureterectomy group occurred in 36 patients (46.2%), with 17 (21.8%) at the urinary bladder, 2 (2.6%) at the retroperitoneum, 1 (1.3%) at the contralateral ureter, 6 (7.7%) with distant metastases to the lung, bone, distant lymph nodes or liver, and 10 (12.8%) at multiple sites.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Survival Rate

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  • (PMID = 16323396.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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98. Malouf G, Falissard B, Azoulay D, Callea F, Ferrell LD, Goodman ZD, Hayashi Y, Hsu HC, Hubscher SG, Kojiro M, Ng IO, Paterson AC, Reynes M, Zafrani ES, Emile JF: Is histological diagnosis of primary liver carcinomas with fibrous stroma reproducible among experts? J Clin Pathol; 2009 Jun;62(6):519-24
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is histological diagnosis of primary liver carcinomas with fibrous stroma reproducible among experts?
  • Little is known about the reproducibility of the pathological diagnosis of primary liver carcinomas.
  • Therefore, this study aimed to evaluate the worldwide variation in the pathological expert diagnoses of primary liver carcinomas with fibrous stroma in patients who did not have cirrhosis.
  • METHODS: A single set of slides was selected from 25 tumours, and this set was reviewed independently by 12 pathologists who have worldwide expertise in liver tumours.
  • RESULTS: The interobserver reproducibility for diagnosis of hepatocellular carcinoma subtypes and cholangiocarcinomas was poor (kappa 0.23-0.52), even when the experts considered that the diagnosis required no additional stains or clinical information.
  • Interestingly, multidimensional scaling revealed three main clusters of tumours: hepatocellular carcinoma with no other specifications (n = 13), fibrolamellar hepatocellular carcinoma (n = 3) and cholangiocarcinoma (n = 9).
  • CONCLUSIONS: The results demonstrate the poor reproducibility among experts of the pathological diagnosis of primary liver carcinomas with fibrous stroma in patients who did not have cirrhosis, and highlight that the systematic use of immunohistochemistry may improve the diagnostic accuracy.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology. Medical Oncology / standards
  • [MeSH-minor] Adolescent. Adult. Aged. Antibodies / analysis. Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / immunology. Child. Cluster Analysis. Diagnosis, Differential. Female. Hepatocytes / pathology. Humans. Immunohistochemistry. Keratin-19 / immunology. Keratin-7 / immunology. Keratins / analysis. Male. Middle Aged. Reproducibility of Results. Young Adult

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  • (PMID = 19155239.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / Keratin-7; 68238-35-7 / Keratins
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99. Uchiyama K, Ueno M, Hama T, Kawai M, Tani M, Terasawa H, Ozawa S, Uemura R, Nakase T, Yamaue H: Recurrence of primary hepatocellular carcinoma after hepatectomy--differences related to underlying hepatitis virus species. Hepatogastroenterology; 2005 Mar-Apr;52(62):591-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of primary hepatocellular carcinoma after hepatectomy--differences related to underlying hepatitis virus species.
  • METHODOLOGY: The patients who had undergone hepatectomy for primary hepatocellular carcinoma (HCC) over the past 10 years at our hospital were divided into three groups based on their underlying causal diseases: hepatitis B (B type), hepatitis C (C type), and non-viral hepatitis including alcoholic hepatitis, and their backgrounds and long-term results after hepatectomy were comparatively investigated.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatectomy. Hepatitis B / complications. Hepatitis C / complications. Liver Neoplasms / surgery. Neoplasm Recurrence, Local
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Risk Factors


100. Zhang GQ, Wang HB, Gao P, Fang CH, Chen GH: [Relationship of extrahepatic metastasis of primary hepatocellular carcinoma between circulative tumor cells in the blood of hepatoma patients]. Zhonghua Wai Ke Za Zhi; 2009 Dec 15;47(24):1857-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Relationship of extrahepatic metastasis of primary hepatocellular carcinoma between circulative tumor cells in the blood of hepatoma patients].
  • OBJECTIVE: To study the relationship between extrahepatic metastasis of primary hepatocellular carcinoma and circulative tumor cells in the blood of hepatoma patients.
  • METHODS: The immunomagnetic bead technique was employed to enrich and separate the hepatoma cells in the peripheral blood of preoperative and postoperative hepatoma patients.
  • The relationship between postoperative extrahepatic metastasis and hepatoma cells in peripheral blood cancer cells were analyzed.
  • The circulative tumor cells in the peripheral blood of hepatoma patients were enriched and separated by immunomagnetic bead technique.
  • They were identified as hepatoma cells by AFP immunohistochemistry.
  • Among 30 cases of hepatoma patients, the positive rate of hepatoma cells in the peripheral blood of preoperation and postoperation were 53.3% and 83.3% respectively.
  • CONCLUSIONS: Extrahepatic metastasis of primary hepatocellular carcinoma is obviously correlated to the positive tumor cells and the concentration in the peripheral blood of preoperative patients.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging

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  • (PMID = 20193401.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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