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Items 1 to 78 of about 78
1. Al-Hussaini M, Sultan I, Abuirmileh N, Jaradat I, Qaddoumi I: Pineal gland tumors: experience from the SEER database. J Neurooncol; 2009 Sep;94(3):351-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pineal gland tumors: experience from the SEER database.
  • Pineal gland tumors are rare and account for less than 1% of all primary brain tumor diagnoses.
  • We analyzed the available SEER data on pineal gland tumors that were diagnosed during the period 1973-2005.
  • The cohort was subdivided into groups on the basis of tumor histology: germ cell tumors, pineal parenchymal tumors, gliomas, and other pineal tumors.
  • Among the 633 patients with pineal tumors, male sex was predominant, i.e., sex ratio was 3:1 for the whole group and 11.8:1 for those with germ cell tumors.
  • Those with germ cell tumors experienced the best survival (OS = 78.9% +/- 2.3%), followed by those with gliomas (OS = 61% +/- 9.3%), and those with pineal parenchymal tumors (OS = 47.2% +/- 4.2%).
  • Non-germ cell tumors, absence of radiotherapy from treatment regimen, and diagnosis before 1993 were the only factors associated with a negative impact on survival.
  • The extent of surgical tumor resection did not affect survival in any histologic subgroup.
  • We conclude that, although pineal tumors are histologically diverse, they share some similarities due to their unique location.
  • Further studies on different pineal tumors subtypes are needed.

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  • (PMID = 19373436.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; None / None / / P30 CA021765-31; United States / NCI NIH HHS / CA / CA21765; United States / NCI NIH HHS / CA / P30 CA021765-31
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS162516; NLM/ PMC2804886
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2. Chang AH, Fuller GN, Debnam JM, Karis JP, Coons SW, Ross JS, Dean BL: MR imaging of papillary tumor of the pineal region. AJNR Am J Neuroradiol; 2008 Jan;29(1):187-9
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  • [Title] MR imaging of papillary tumor of the pineal region.
  • We report the imaging features of 4 cases of patients with papillary tumor of the pineal region, a tumor newly recognized in the 2007 World Health Organization "Classification of Tumors of the Nervous System."
  • In each case, the tumor was intrinsically hyperintense on T1-weighted images with a characteristic location in the posterior commissure or pineal region.
  • The pathologic hallmarks of the tumor are discussed, including a possible explanation for the MR imaging characteristics in our cases.
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma, Papillary / pathology. Magnetic Resonance Imaging / methods. Pineal Gland / pathology
  • [MeSH-minor] Adult. Female. Humans. Middle Aged

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  • (PMID = 17925365.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Parwani AV, Baisden BL, Erozan YS, Burger PC, Ali SZ: Pineal gland lesions: a cytopathologic study of 20 specimens. Cancer; 2005 Apr 25;105(2):80-6
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  • [Title] Pineal gland lesions: a cytopathologic study of 20 specimens.
  • BACKGROUND: Pineal gland lesions are rare, with only a few cytologic descriptions occurring in the literature, according to the authors' knowledge.
  • The 20 specimens include pineoblastoma (five specimens), pineocytoma (four specimens), astrocytoma (three specimens), germ cell tumor (three specimens), meningioma (one specimen), epidermoid cyst (three specimens), and pineal cyst (one specimen).
  • In selected specimens, immunoperoxidase (IPOX) stains were performed on cell block sections using synaptophysin, neuron-specific enolase, placental alkaline phosphatase, glial fibrillary acidic protein, leukocyte common antigen, cytokeratins, and human chorionic gonadotropin antibodies.
  • The unique features included the following: small, hyperchromatic, round to oval cells with frequent rosetting (pineocytoma), with a few specimens in addition showing hypercellularity, crowding, mitoses, and necrosis (pineoblastoma); pleomorphic round cells in a fibrillary background (astrocytoma); large polygonal cells with prominent nucleoli and clear cytoplasm (germ cell tumor); spindled fibroblastic cells (meningioma); anucleate squames and mature squamous cells (epidermoid cyst); and small uniform polygonal cells (pineal cyst).
  • CONCLUSIONS: FNAB and TI cytology were found to provide a rapid and reliable diagnosis of pineal lesions.
  • IPOX studies played an important complementary role in difficult cases when performed on cell blocks.
  • [MeSH-major] Cysts / pathology. Pineal Gland. Pinealoma / pathology
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / pathology. Biopsy, Fine-Needle. Child. Child, Preschool. Diagnosis, Differential. Epidermal Cyst / pathology. Female. Germinoma / pathology. Humans. Infant. Male. Middle Aged

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  • [Copyright] 2005 American Cancer Society.
  • (PMID = 15662708.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Boco T, Aalaei S, Musacchio M, Byrne R, Cochran E: Papillary tumor of the pineal region. Neuropathology; 2008 Feb;28(1):87-92
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  • [Title] Papillary tumor of the pineal region.
  • Primary pineal gland malignancies are uncommon and seldom have papillary architecture.
  • MRI of the brain showed a lesion in the pineal region.
  • The patient was taken for resection of the lesion which was classified as papillary tumor of pineal region (PTPR).
  • Histologically, the neoplasm was cellular, characterized by eosinophilic cells with indistinct borders, large pleomorphic nuclei, numerous apoptotic figures without necrosis or microvascular proliferation.
  • This is a case report of this rare pineal region neoplasm which only recently has been described as a histopathologic entity.
  • Although the clinicopathological characteristics of this tumor are not entirely understood, a brief review of the literature as well as our contribution suggest an indolent neoplasm with a tendency for local recurrence.
  • The differential diagnosis of papillary neoplasms of the pineal region is reviewed.
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma, Papillary / pathology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Diplopia / etiology. Headache / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Nystagmus, Pathologic / etiology. Radiotherapy

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  • (PMID = 18069972.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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5. Levidou G, Korkolopoulou P, Agrogiannis G, Paidakakos N, Bouramas D, Patsouris E: Low-grade oligodendroglioma of the pineal gland: a case report and review of the literature. Diagn Pathol; 2010;5:59
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  • [Title] Low-grade oligodendroglioma of the pineal gland: a case report and review of the literature.
  • BACKGROUND: Gliomas are a very rare subtype of pineal region tumours, whereas oligodendrogliomas of the pineal region are exceedingly rare, since there have been only 3 cases of anaplastic oligodedrogliomas reported this far.
  • METHODS-RESULTS: We present a case of a low-grade oligodendroglioma arising in the pineal gland of a 37 year-old woman.
  • The patient presented with diplopia associated with a cystic pineal region mass demonstrated on MRI.
  • However, the diagnosis of a low grade oligodendroglioma of the pineal gland was assigned.
  • CONCLUSION: Although the spectrum of tumours arising in the pineal gland is broad, the reports of oligodendrogliomas confined to this location are exceedingly rare, and to the best of our knowledge there is no report of a low-grade oligodendroglioma.
  • However, they should be added in the long list of tumours arising in the pineal gland.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cell Proliferation. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Magnetic Resonance Imaging. Neoplasm Staging

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  • (PMID = 20849631.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2949720
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6. Srinivasan N, Pakala A, Mukkamalla C, Oswal A: Pineal germinoma. South Med J; 2010 Oct;103(10):1031-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pineal germinoma.
  • Newly diagnosed adult cases of pineal gland germinomas are very rare since most of the cases are diagnosed in the mid teens.
  • The estimated incidence of this tumor in western countries is between 0.4-3.4%.
  • Typically, this tumor is diagnosed by its characteristic radiological appearance alone, supported by tumor marker(s) or by stereotactic biopsy of the tumor.
  • We are reporting a very unique case of pineal germinoma diagnosed in an adult at our institute by cerebrospinal fluid cytology with literature review.
  • We analyzed case reports, literature reviews, and therapy and diagnostic articles about pineal germinoma in the English literature from 1983 to 2009 through the national library of medicine, Pubmed, and OVID search engines.
  • We used key words "pineal germinoma," "pineal gland tumor," "CNS germinoma," and "extragonodal germinomas" to search for our articles.
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Pituitary Hormones / blood. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 20818311.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pituitary Hormones
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7. Rothman J, Greenberg RE, Jaffe WI: Nonseminomatous germ cell tumor of the testis 9 years after a germ cell tumor of the pineal gland: case report and review of the literature. Can J Urol; 2008 Jun;15(3):4122-4
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  • [Title] Nonseminomatous germ cell tumor of the testis 9 years after a germ cell tumor of the pineal gland: case report and review of the literature.
  • Extragonadal germ cell tumors are extremely rare and account for only 3%-5% of all germ cell tumors.
  • These tumors are rarely associated with metachronous primary testicular germ cell tumors.
  • We report the fourth case of a primary germ cell tumor occurring after the treatment of a primary CNS germ cell tumor in a 27 year-old male with embryonal cell carcinoma of the testicle 9 years after the treatment of a germ cell tumor of the pineal gland.
  • This represents the first case of a non-seminomatous germ cell tumor of the testicle after a CNS germ cell tumor.
  • This case illustrates the importance of long term follow-up and self-examination in patients with extragonadal germ cell tumors.
  • [MeSH-major] Brain Neoplasms. Carcinoma, Embryonal. Neoplasms, Germ Cell and Embryonal. Neoplasms, Second Primary. Pineal Gland. Testicular Neoplasms
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 18570724.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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8. Srinivas BH, Uppin MS, Panigrahi MK, Vijaya Saradhi M, Jyotsna Rani Y, Challa S: Pleomorphic xanthoastrocytoma of the pineal region. J Clin Neurosci; 2010 Nov;17(11):1439-41
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  • [Title] Pleomorphic xanthoastrocytoma of the pineal region.
  • Pleomorphic xanthoastrocytomas are indolent, astrocytic tumors usually located in the superficial cerebral cortex.
  • They have not been described as occurring in the pineal region.
  • We describe a patient with an astrocytic tumor arising in the pineal region that fulfilled all of the morphologic and immunohistochemical criteria of a pleomorphic xanthoastrocytoma.
  • To our knowledge, this is the first description of a pleomorphic xanthoastrocytoma located in the pineal region.
  • [MeSH-major] Astrocytoma / diagnosis. Pineal Gland / pathology. Pinealoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Headache / diagnosis. Headache / etiology. Humans. Magnetic Resonance Imaging / methods. Male. Ocular Motility Disorders / diagnosis. Ocular Motility Disorders / etiology. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20655751.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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9. Elizondo ZA, Montelongo MR, González JE: [Extragonadal germ cell tumor in mediastinum: case report]. Actas Urol Esp; 2008 Mar;32(3):357-9
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  • [Title] [Extragonadal germ cell tumor in mediastinum: case report].
  • [Transliterated title] Tumor extragonadal de células germinales en mediastino: aportación de un caso.
  • The Germ Cell tumors of extragonadal origin are infrequent cases being described in literature less than 1000 cases.
  • The frequent origin sites are mediastinum, retroperitoneum, sacrococcygeal region, and the pineal gland.
  • Normal tumor markers, testicular ultrasonography reported the presence of bilateral microlitiasis.
  • [MeSH-major] Mediastinal Neoplasms. Neoplasms, Germ Cell and Embryonal
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 18512396.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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10. Ghosal N, Furtado SV, Hegde AS: Rosette forming glioneuronal tumor pineal gland and tectum: an intraoperative diagnosis on smear preparation. Diagn Cytopathol; 2010 Aug;38(8):590-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rosette forming glioneuronal tumor pineal gland and tectum: an intraoperative diagnosis on smear preparation.
  • We present an extremely rare case of newly described entity called rosette forming glioneuronal tumor (RGNT), involving the pineal gland, tectum, and the adjacent thalamus in a 22-year-old male.
  • The tumor was diagnosed intraoperatively on smear preparation on cytomorphology.
  • If sampled adequately, it is fairly easy to diagnose RGNT on smear preparation as it has a very distinctive cytomorphology of being composed of two population of cell.
  • [MeSH-major] Brain Neoplasms / diagnosis. Cytological Techniques / methods. Glioma / diagnosis. Intraoperative Care. Pineal Gland / pathology. Rosette Formation. Tectum Mesencephali / pathology
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Young Adult

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19941371.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Arivazhagan A, Anandh B, Santosh V, Chandramouli BA: Pineal parenchymal tumors--utility of immunohistochemical markers in prognostication. Clin Neuropathol; 2008 Sep-Oct;27(5):325-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pineal parenchymal tumors--utility of immunohistochemical markers in prognostication.
  • BACKGROUND AND OBJECTIVE: The pineal parenchymal tumors are rare, comprising 15-30% of all tumors of pineal region.
  • METHODS: A retrospective analysis of 33 pineal parenchymal tumors treated from 1990-2004 was performed.
  • The histological features of the tumors were reviewed and immunohistochemical staining for neurofilament protein (NF), MIB-1, synaptophysin and GFAP were performed.
  • RESULTS: The study comprised 6 pineocytomas (PC), 17 pineoblastomas (PB) and 10 pineal parenchymal tumors with intermediate differentiation (PPT-ID) which included 3 mixed PC/PB.
  • All the tumors stained positive for synaptophysin, although the intensity of the staining varied.
  • NF-positive tumors had a higher chance of disease-free state, irrespective of histological subgroup (p = 0.0036).
  • CONCLUSIONS: Neurofilament immunoreactivity indicates better prognosis in pineal parenchymal tumors.
  • The MIB-1 labeling index can be utilized as an additional tool to differentiate pineal parenchymal tumors into various subgroups.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Pineal Gland / metabolism. Pineal Gland / pathology. Pinealoma / metabolism
  • [MeSH-minor] Adolescent. Adult. Antibodies, Antinuclear / metabolism. Antibodies, Monoclonal / metabolism. Biomarkers, Tumor / analysis. Child. Child, Preschool. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Infant. Kaplan-Meier Estimate. Middle Aged. Mitotic Index. Neurofilament Proteins / biosynthesis. Prognosis. Retrospective Studies. Synaptophysin / metabolism

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  • (PMID = 18808064.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / MIB-1 antibody; 0 / Neurofilament Proteins; 0 / Synaptophysin
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12. Sasaki A, Horiguchi K, Nakazato Y: Pineal parenchymal tumor of intermediate differentiation with cytologic pleomorphism. Neuropathology; 2006 Jun;26(3):212-7
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  • [Title] Pineal parenchymal tumor of intermediate differentiation with cytologic pleomorphism.
  • We report a case of pineal parenchymal tumor in a 33-year-old man incidentally detected by radiological examination.
  • The MRI showed an unhomogeneously enhanced, small tumor (approximately 1 cm in size) in the pineal region.
  • A tumor specimen was obtained at endoscopic biopsy.
  • Routine histology showed a highly cellular tumor characterized by a predominance of small cells showing high nuclear : cytoplasmic ratio and moderate nuclear atypia, pleomorphism including giant cells and an absence of pineocytomatous rosettes.
  • Tumor necrosis was not evident.
  • Thus, the tumor was confirmed as a pineal parenchymal tumor of intermediate differentiation by histology, immunohistochemistry and electron microscopy.
  • This case indicates that marked cytologic pleomorphism can occur in pineal parenchymal tumors of intermediate differentiation.
  • [MeSH-major] Brain Neoplasms / pathology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cell Differentiation. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Microscopy, Electron, Transmission

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  • (PMID = 16771177.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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13. Sorimachi T, Sasaki O, Nakazato S, Koike T, Shibuya H: Myxoid chondrosarcoma in the pineal region. J Neurosurg; 2008 Nov;109(5):904-7
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  • [Title] Myxoid chondrosarcoma in the pineal region.
  • The authors report a case of a myxoid chondrosarcoma of the pineal region in a 37-year-old woman who presented with an intratumoral hemorrhage.
  • Partial removal of the tumor in an initial surgery resulted in failure to establish a definitive diagnosis.
  • The residual tumor enlarged after a second intratumoral hemorrhage 14 months after the onset of the first symptoms, and gross-total resection of the tumor was achieved in a second surgery.
  • Radical excision of a tumor was considered to play an important role in the management of intracranial myxoid chondrosarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Pineal Gland
  • [MeSH-minor] Adult. Female. Hemorrhage / etiology. Humans. Magnetic Resonance Imaging

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  • (PMID = 18976082.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Kim YH, Kim JW, Park CK, Kim DG, Sohn CH, Chang KH, Park SH: Papillary tumor of pineal region presenting with leptomeningeal seeding. Neuropathology; 2010 Dec;30(6):654-60
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  • [Title] Papillary tumor of pineal region presenting with leptomeningeal seeding.
  • Papillary tumor of the pineal region (PTPR) is a recently recognized and rare pineal tumor, presenting as a solitary mass with or without hydrocephalus.
  • MRI showed a large, 4 cm-diameter solid and cystic enhancing mass at the pineal region with associated ventriculomegaly.
  • The specimen was small in quantity but nonetheless, revealed the typical features of PTPR, which were tumor cells with vacuolated cytoplasm forming a pseudopapillary architecture.
  • The tumor cells were diffusely immunoreactive for vimentin, INI-1 and c-Kit, focally immunoreactive for neuronal specific enolase (NSE) and S100 protein but negative for cytokeratin, epithelial membrane antigen (EMA), synaptophysin and GFAP.
  • Ultrastructurally, the tumor cells revealed variably-sized cytoplasmic vacuoles, intermediate filaments and villous cytoplasmic membrane.
  • The lesions at the pineal gland and bilateral IAC were irradiated through gamma knife radiosurgery and a decrease in size of the lesions was noted on follow-up MRI.
  • This case was a c-kit expressing PTPR, which might represent the more primitive nature of this tumor.
  • Ultrastructural examination is useful to differentiate PTPR from other tumors of the pineal gland in addition to immunohistochemistry.
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Radiosurgery. Stem Cell Factor / biosynthesis

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  • [Copyright] © 2010 Japanese Society of Neuropathology.
  • (PMID = 20374498.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Stem Cell Factor
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15. Kern M, Robbins P, Lee G, Watson P: Papillary tumor of the pineal region--a new pathological entity. Clin Neuropathol; 2006 Jul-Aug;25(4):185-92
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  • [Title] Papillary tumor of the pineal region--a new pathological entity.
  • Papillary tumor of the pineal region has recently been proposed as a new, distinct clinicopathological entity.
  • We present the third publication on a papillary pineal tumor and describe the morphological, immunohistochemical and ultrastructural features of this neoplasm.
  • Magnetic resonance imaging revealed a neoplastic lesion in the pineal region.
  • She underwent surgical resection of the tumor through a midline infratentorial-supracerebellar approach.
  • Papillary tumor of the pineal region represents a new, distinct clinicopathological entity.
  • [MeSH-major] Brain Neoplasms / pathology. Papilloma / pathology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Dose Fractionation. Female. Humans. Treatment Outcome

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  • (PMID = 16866300.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Shibui S, Nomura K: Statistical analysis of pineal tumors based on the data of Brain Tumor Registry of Japan. Prog Neurol Surg; 2009;23:1-11
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  • [Title] Statistical analysis of pineal tumors based on the data of Brain Tumor Registry of Japan.
  • In this study, we present statistical analyses of pineal tumors based on the data from Brain Tumor Registry of Japan.
  • The most frequent tumor in the pineal region was germinoma, and it accounted for 49.2% of all pineal tumors; it was followed by pineocytoma (8.5%), glioma (6.5%), pineoblastoma (5.1%), malignant teratoma (5.2%) and teratoma (5.1%).
  • Germinoma is most frequent among patients between 10 and 19 years of age, and there are some patients aged >30 years; however, there are few patients with choriocarcinoma, embryonal carcinoma, and yolk sac tumor who are aged >30 years.
  • The 5-year survival rate of germinoma was 89.4%, while those of embryonal carcinoma, yolk sac tumor and choriocarcinoma were 35.3, 37.3 and 58.1%, respectively.
  • [MeSH-major] Brain Neoplasms / epidemiology. Germinoma / epidemiology. Pineal Gland. Pinealoma / epidemiology. Registries / statistics & numerical data
  • [MeSH-minor] Adult. Age Distribution. Aged. Female. Glioma / epidemiology. Humans. Incidence. Japan / epidemiology. Male. Middle Aged. Sex Distribution. Teratoma / epidemiology. Young Adult

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19329857.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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17. Bookland M, Anderson WS, Biser-Rohrbaugh A, Jallo GI: Primary pineal malignant melanoma. Pediatr Neurosurg; 2007;43(4):303-8
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  • [Title] Primary pineal malignant melanoma.
  • Primary pineal malignant melanomas are a rare subset of primary central nervous system melanomas.
  • This report presents the case of a 20-year-old female patient with a primary pineal region malignant melanoma who underwent endoscopic biopsy and adjuvant therapy.
  • Her treatment consisted of stereotactic radiation to the pineal tumor, conventional whole-brain radiation and Temodar(R) for the disseminated disease.
  • This report details the clinical features of the case and summarizes the literature on a rare but aggressive neoplasm.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Melanoma / diagnosis. Melanoma / therapy. Pineal Gland
  • [MeSH-minor] Adult. Female. Humans

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17627147.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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18. Smith AB, Rushing EJ, Smirniotopoulos JG: From the archives of the AFIP: lesions of the pineal region: radiologic-pathologic correlation. Radiographics; 2010 Nov;30(7):2001-20
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  • [Title] From the archives of the AFIP: lesions of the pineal region: radiologic-pathologic correlation.
  • Lesions of the pineal region include a diverse group of entities.
  • The most common neoplastic lesions are the germ cell tumors.
  • Germ cell tumors may be hormonally active, and evaluation of serum or cerebrospinal fluid levels of oncoproteins assists in making the diagnosis.
  • Neoplasms arising from the pineal parenchyma include the low-grade pineocytoma, pineal parenchymal tumor of intermediate differentiation, and the highly malignant pineoblastoma.
  • Germ cell tumors and pineal parenchymal neoplasms do not have pathognomonic imaging findings, but imaging in combination with laboratory evaluation helps narrow the differential diagnosis.
  • Neoplasms may also arise from the variety of cell types residing in the proximity of the pineal gland.
  • Knowledge of the variety of lesions that occur in the pineal region, their imaging appearances, and their clinical features assists in narrowing the radiologic differential diagnosis and optimizing patient treatment.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 21057132.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Mori Y, Kobayashi T, Hasegawa T, Yoshida K, Kida Y: Stereotactic radiosurgery for pineal and related tumors. Prog Neurol Surg; 2009;23:106-18
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  • [Title] Stereotactic radiosurgery for pineal and related tumors.
  • Radiosurgery is increasingly being used to treat pineal region tumors, either as an additional therapy after conventional treatments or as a primary treatment.
  • We report our experience with Gamma Knife radiosurgery (GKRS) for the treatment of pineal and related tumors.
  • Forty-nine patients underwent GKRS for pineal and related tumors (n = 74) between February 1992 and September 2007.
  • The diagnosis was germ cell tumors (GCTs) in 38 patients (53 tumors), pineal parenchymal tumors (PPTs) in 9 (19 tumors), and unknown in 2 (2 tumors).
  • One patient (one tumor) with pineocytoma was lost to follow-up.
  • We evaluated the treatment results with categorization of GCT cases into 2 groups, i.e. germinoma (group 1), and germinoma with syncytiotrophoblastic giant cell and malignant GCT (group 2).
  • Local tumor control (LTC) rates at 3 and 5 years were 82% in group 1 (n = 18), 72 and 62% in group 2 (n = 35), and 85% in group 3 (n = 13).
  • Intermediate prognosis was obtained in germinoma with syncytiotrophoblastic giant cell and malignant GCT.
  • GKRS is expected to be an effective and safe adjuvant treatment approach to pineal and related tumors.
  • [MeSH-major] Brain Neoplasms / surgery. Pineal Gland / surgery. Pinealoma / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Young Adult

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19329865.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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20. Fèvre-Montange M, Grand S, Champier J, Hoffmann D, Pasquier B, Jouvet A: Bcl-2 expression in a papillary tumor of the pineal region. Neuropathology; 2008 Dec;28(6):660-3
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  • [Title] Bcl-2 expression in a papillary tumor of the pineal region.
  • Neuroepithelial papillary tumor of the pineal region (PTPR) has been described by several groups and recognized by the 2007 World Health Organization Classification of Tumors of the Central Nervous System.
  • It may also be involved in neuroendocrine differentiation in some tumors.
  • Bcl-2 immunostaining was detected in the cytoplasm of the tumoral cells; staining intensity was heterogeneous from cell to cell and more intense in papillary areas.
  • This intense expression of Bcl-2 in one case of PTPR with a high proliferation index (8%) might be related to the malignancy of this neoplasm.
  • [MeSH-major] Brain Neoplasms / metabolism. Neoplasms, Neuroepithelial / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism
  • [MeSH-minor] Adult. Basal Ganglia / pathology. Biopsy. Cerebral Cortex / pathology. Cytoplasm / metabolism. Epithalamus / pathology. Female. Hippocampus / pathology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Pineal Gland

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  • (PMID = 18410278.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
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21. Durko M, Jankowski A, Durko T, Gajewicz W, Pajor A: [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness]. Otolaryngol Pol; 2008;62(2):204-8
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  • [Title] [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness].
  • INTRODUCTION: Acoustic neuroma usually presents as an unilateral tumor, seldom - bilateral and rarely in coexistence with other central nervous system neoplasms.
  • MRI study revealed in the left internal acoustic meatus mass (7 x 7 x 14 mm) suggesting acoustic neuroma and an oval mass (7 x 9 x 14 mm) in the pineal gland presenting radiological features of pinealoma.
  • [MeSH-minor] Adult. Audiometry, Pure-Tone. Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / etiology. Humans. Male. Tinnitus / diagnosis. Tinnitus / etiology. Treatment Outcome. Vertigo / diagnosis. Vertigo / etiology

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  • (PMID = 18637448.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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22. Sharma MC, Jain D, Sarkar C, Suri V, Garg A, Sharma BS, Mehta VS: Papillary tumor of the pineal region--a recently described entity: a report of three cases and review of the literature. Clin Neuropathol; 2009 Jul-Aug;28(4):295-302
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  • [Title] Papillary tumor of the pineal region--a recently described entity: a report of three cases and review of the literature.
  • BACKGROUND: The papillary tumor of the pineal region (PTPR) is a distinct clinicopathologic entity, the exact biological behavior of which is not known.
  • During a study period of 4 years (between January 2003 and December 2006), we diagnosed three cases of papillary tumor of the pineal region (PTPR).
  • CONCLUSION: PTPR is a distinct entity and needs to be differentiated from other tumors of the pineal region as the biological behavior of this tumor is not fully understood.
  • Radiologically this tumor can sometimes be misdiagnosed as tectal glioma.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Pineal Gland / metabolism. Pineal Gland / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male

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  • (PMID = 19642509.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 22
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23. Pontes GN, Cardoso EC, Carneiro-Sampaio MM, Markus RP: Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes. J Pineal Res; 2006 Sep;41(2):136-41
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  • [Title] Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes.
  • A large number of data show that melatonin has immunomodulatory properties and is produced by immunocompetent cells; also, some evidence suggests a 'feedback' of the activated immune system on the pineal gland.
  • In this paper, we studied immune-pineal interactions in colostrum obtained from healthy puerperae and mothers with mastitis taking into account that, (a) melatonin levels in milk reflects pineal activity and (b) colostrum quiescent mononuclear and polymorphonuclear phagocytes from healthy mothers in culture are adequate for evaluating the ability of immunocompetent cells to produce melatonin.
  • Here we compared the diurnal and nocturnal melatonin levels in colostrum from healthy puerperae and mothers with mastitis; this is a unique noninvasive model for determining pineal activity in the proinflammatory phase of a defense response.
  • Suppression of nocturnal melatonin rise in mothers with mastitis was highly correlated with increased tumor necrosis factor-alpha (TNF-alpha) secretion.
  • This result, interpreted taking into account the presence of the transcription factor nuclear factor kappa B in pineal gland, suggest that the proinflammatory cytokine can inhibit nocturnal pineal melatonin production.
  • These results suggest that during the response to an injury the production of melatonin can be transiently shifted from an endocrine (pineal) to a paracrine (immunocompetent cells) source.
  • [MeSH-major] Colostrum / chemistry. Mastitis / metabolism. Melatonin / biosynthesis. Paracrine Communication. Phagocytes / metabolism. Pineal Gland / metabolism
  • [MeSH-minor] Adolescent. Adult. Escherichia coli / immunology. Female. Humans. Infant. Postpartum Period. Pregnancy. Tumor Necrosis Factor-alpha / analysis. Zymosan / immunology

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  • (PMID = 16879319.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; 9010-72-4 / Zymosan; JL5DK93RCL / Melatonin
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24. Khawam E, Fahed D, Khatib L: Isolated inferior rectus paresis with falling eye phenomenon of the contralateral eye in a patient with pineal tumor: a case report. Binocul Vis Strabismus Q; 2010;25(1):31-6
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  • [Title] Isolated inferior rectus paresis with falling eye phenomenon of the contralateral eye in a patient with pineal tumor: a case report.
  • PRUPOSE: To report a patient who developed an isolated inferior rectus paresis due to a pineal gland tumor, and to our knowledge never reported before.
  • CASE REPORT: A patient with pineal gland tumor demonstrated findings characteristic of unilateral isolated inferior rectus paresis.
  • CONCLUSION: Although bilateral sixth nerve paresis and Parinaud's syndrome are commonly reported in pineal gland tumors; in the the presence of an isolated inferior rectus palsy, one should also consider the pineal gland as the causative factor.
  • [MeSH-major] Brain Neoplasms / complications. Germinoma / complications. Ophthalmoplegia / etiology. Pineal Gland / pathology

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  • (PMID = 20361865.001).
  • [ISSN] 1088-6281
  • [Journal-full-title] Binocular vision & strabismus quarterly
  • [ISO-abbreviation] Binocul Vis Strabismus Q
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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25. Leston J, Mottolese C, Champier J, Jouvet A, Brun J, Sindou M, Chazot G, Claustrat B, Fèvre-Montange M: Contribution of the daily melatonin profile to diagnosis of tumors of the pineal region. J Neurooncol; 2009 Jul;93(3):387-94
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  • [Title] Contribution of the daily melatonin profile to diagnosis of tumors of the pineal region.
  • Tumors of the pineal region (TPR) include different entities: germ cell tumors (GCT), pineal parenchymal tumors (PPT), meningiomas, and glial tumors.
  • Before surgery, a melatonin nycthemeral rhythm was observed in patients with TPG and TPR (one cyst, three PPT, one papillary tumor of the pineal region, two meningiomas, six gliomas).
  • Melatonin rhythm was dramatically reduced for undifferentiated or invasive tumors.
  • After surgery, the absence of melatonin variation in some cases could be the consequence of pineal damage by surgery.
  • [MeSH-major] Biomarkers, Tumor / blood. Brain Neoplasms / blood. Melatonin / blood. Pineal Gland / pathology. Pinealoma / blood
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Circadian Rhythm / physiology. Female. Humans. Male. Middle Aged. Neurosurgical Procedures. Radioimmunoassay. Young Adult

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  • (PMID = 19169855.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; JL5DK93RCL / Melatonin
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26. Kano H, Niranjan A, Kondziolka D, Flickinger JC, Lunsford D: Role of stereotactic radiosurgery in the management of pineal parenchymal tumors. Prog Neurol Surg; 2009;23:44-58
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  • [Title] Role of stereotactic radiosurgery in the management of pineal parenchymal tumors.
  • We evaluated 20 pineal parenchymal tumor patients who underwent radiosurgery at our institution over a 20-year period.
  • Thirteen patients had pineocytoma, 5 patients had pineoblastoma and 2 patients had mixed pineal parenchymal tumors.
  • The median radiosurgery prescription dose to the tumor margin was 15.0 (12-20) Gy.
  • In 19 patients who were evaluated with imaging, 5 (26%) demonstrated complete regression, 9 (47%) had partial regression, 2 (11%) had stable tumors and 2 (11%) showed local in-field progression.
  • The progression-free survival after stereotactic radiosurgery for all type of pineal parenchymal tumors was 100, 89.2 and 89.2% at 1, 3, 5 years after radiosurgery, respectively.
  • Stereotactic radiosurgery is an effective and safe alternative to the surgical resection of pineocytomas as well as part of multimodal therapy for more aggressive pineal parenchymal tumors.
  • [MeSH-major] Brain Neoplasms / surgery. Pineal Gland / surgery. Pinealoma / surgery. Radiosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Child. Child, Preschool. Female. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Young Adult

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19329860.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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27. Dagnew E, Langford LA, Lang FF, DeMonte F: Papillary tumors of the pineal region: case report. Neurosurgery; 2007 May;60(5):E953-5; discussion E953-5
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  • [Title] Papillary tumors of the pineal region: case report.
  • OBJECTIVE: The pineal region is a rare intracranial site for metastasis.
  • We report three patients initially considered to have metastatic papillary adenocarcinoma to the pineal region.
  • On review, these papillary, keratin-positive neoplasms meet the criteria for papillary tumor of the pineal region (PTPR).
  • Imaging studies demonstrated well-circumscribed lesions in the pineal region.
  • INTERVENTION: All three patients underwent near total microsurgical resection of the pineal region neoplasm, followed by adjuvant radiotherapy.
  • CONCLUSION: The morphological features of the tumors in our series, along with the clinical presentations, are similar to those in the original description of the PTPR.
  • [MeSH-major] Brain Neoplasms / diagnosis. Pineal Gland / pathology. Pinealoma / diagnosis
  • [MeSH-minor] Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / surgery. Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 17460510.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Fèvre-Montange M, Champier J, Szathmari A, Wierinckx A, Mottolese C, Guyotat J, Figarella-Branger D, Jouvet A, Lachuer J: Microarray analysis reveals differential gene expression patterns in tumors of the pineal region. J Neuropathol Exp Neurol; 2006 Jul;65(7):675-84
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  • [Title] Microarray analysis reveals differential gene expression patterns in tumors of the pineal region.
  • Several types of tumors are known to originate from the pineal region, among them pineal parenchymal tumors (PPTs) and papillary tumors of the pineal region (PTPRs), probably derived from the subcommissural organ.
  • To identify molecular markers, using CodeLink oligonucleotide arrays, gene expression was studied in 3 PPTs (2 pineocytomas and one pineoblastoma), 2 PTPRs, and one chordoid glioma, another rare tumor of the third ventricle.
  • Our results highlight the usefulness of gene expression profiling for classify tumors of the pineal region and identify genes with potential use as diagnostic markers.
  • [MeSH-major] Biomarkers, Tumor / genetics. Brain Neoplasms / genetics. Gene Expression Profiling / utilization. Gene Expression Regulation. Pineal Gland. Pinealoma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cluster Analysis. Female. Humans. Infant. Male. Middle Aged. Molecular Sequence Data. Oligonucleotide Array Sequence Analysis

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  • (PMID = 16825954.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Senft C, Raabe A, Hattingen E, Sommerlad D, Seifert V, Franz K: Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity. Neurosurg Rev; 2008 Apr;31(2):231-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pineal parenchymal tumor of intermediate differentiation: diagnostic pitfalls and discussion of treatment options of a rare tumor entity.
  • Tumors of the pineal region are uncommon, comprising approximately 0.4-1% of all intracranial tumors in adults in European and American series.
  • Histopathologically, they are a very heterogeneous group of tumors.
  • Of genuine pineal tumors, pineal parenchymal tumors of intermediate differentiation (PPTIDs) are the least frequently found type.
  • There was no clear connection of the tumor to the pineal gland.
  • Differential diagnosis included all intraventricular and midline tumors, therefore a biopsy was taken.
  • Preliminary histopathological diagnosis was germinoma or primitive neuroectodermal tumor, and the tissue sample was reexamined by a referential neuropathological institute.
  • The tumor was then resected through a transventricular/transchoroidal approach.
  • Histopathological examination of tumor specimen confirmed the diagnosis of a PPTID.
  • At 1-year follow-up, there are no signs of tumor regrowth.
  • Diagnosis of pineal parenchymal tumors in general and PPTIDs in particular can be troublesome.
  • Their histopathological features are still being defined, as is the biological behavior of the different tumor entities.
  • We recommend surgical removal of PPTID, preferably in toto whenever the size of the tumor permits that kind of excision.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / surgery. Neuroectodermal Tumors, Primitive / diagnosis. Neuroectodermal Tumors, Primitive / surgery. Pinealoma / diagnosis. Pinealoma / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Gait Disorders, Neurologic / etiology. Headache / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Paraffin Embedding. Radionuclide Imaging. Radiosurgery. Third Ventricle / diagnostic imaging. Third Ventricle / pathology. Tomography, X-Ray Computed. alpha-Fetoproteins / metabolism

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  • (PMID = 18266015.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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30. Endo H, Kumabe T, Jokura H, Tominaga T: Stereotactic radiosurgery followed by whole ventricular irradiation for primary intracranial germinoma of the pineal region. Minim Invasive Neurosurg; 2005 Jun;48(3):186-90
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  • [Title] Stereotactic radiosurgery followed by whole ventricular irradiation for primary intracranial germinoma of the pineal region.
  • Three patients with pineal germinoma were treated with stereotactic radiosurgery using the gamma knife (10 - 12 Gy) to the tumors followed by whole ventricular irradiation (24 Gy).
  • All patients had solitary pineal tumor measuring less than 3 cm, clinically compatible with germinoma, normal cerebrospinal fluid (CSF) and serum levels of alpha-fetoprotein and beta-human chorionic gonadotropin, no disseminated disease on spinal magnetic resonance (MR) imaging, and no abnormal CSF cytology.
  • All patients showed complete response to the combined radiotherapy, and MR imaging has shown no recurrence of the tumor.
  • Combined radiotherapy using gamma knife radiosurgery is effective for pineal germinoma, and reduced the cost of treatment with less need for hospitalization.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Brain Neoplasms / surgery. Germinoma / radiotherapy. Germinoma / surgery. Pineal Gland. Radiosurgery
  • [MeSH-minor] Adult. Humans. Male. Third Ventricle. Treatment Outcome

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  • (PMID = 16015498.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 25
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31. Qiu BH, Fang LX, Zhang XA, Qi ST: [Clinical study of pineal region tumors: experience with 132 patients]. Zhonghua Zhong Liu Za Zhi; 2010 Jun;32(6):441-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study of pineal region tumors: experience with 132 patients].
  • OBJECTIVE: To review the clinical manifestations, imaging, tumor markers, treatment methods, pathology results and clinical curative effects of pineal region tumors and to evaluate the characteristics and intervention strategies for those tumors.
  • METHODS: The clinicopathological data of 132 patients with pineal region tumor treated in our department between January 2000 and May 2008 were retrospectively studied.
  • 114 cases had pathology results including 56 germ cell tumors.
  • CONCLUSION: Pineal region tumors are often associated with hydrocephalus and this makes preoperative diagnosis difficult.
  • Germ cell tumors may diagnosed by some tumor markers.
  • Other types of pineal region tumors should receive surgical treatment.
  • Postoperative adjuvant treatment based on pathology can provide a good prognosis in pineal region tumor.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Pineal Gland / pathology. Pinealoma / diagnosis. Pinealoma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Chorionic Gonadotropin / blood. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Hydrocephalus / etiology. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Sex Factors. Survival Rate. Tomography, X-Ray Computed. Young Adult. alpha-Fetoproteins / metabolism

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  • (PMID = 20819486.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / alpha-Fetoproteins
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32. Kim DS, Shim KW, Kim TG, Chang JH, Park YG, Choi JU: Pineal cavernous malformations: report of two cases. Yonsei Med J; 2005 Dec 31;46(6):851-8

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  • [Title] Pineal cavernous malformations: report of two cases.
  • Pineal hemorrhage only occurs in rare cases, and this known to have several different causes such as germ cell tumors, pineal cysts and vascular malformations, including the cavernous malformations.
  • Pineal cavernous malformations are extremely rare: to date only fifteen cases have been reported worldwide.
  • Although the diagnosis of pineal cavernous malformation is not easy because of the extreme rareness of this condition, the presence of this lesion can be suspected based on its typical radiological findings. Case 1.
  • Radiologic examinations showed acute hemorrhage in the pineal region.
  • We operated and totally removed the tumor and the hemorrhages via an occipital-transtentorial approach. Case 2.
  • We operated and totally removed the tumor and the hemorrhages via an occipital-transtentorial approach.
  • If there is no doubt about the pineal cavernous malformation on MR imaging, we strongly recommend early surgical intervention without performing a risky biopsy.
  • In this study, we describe our experiences for the diagnosis of cavernous malformations in the pineal region with special emphasis on the radiological aspects and the clinical course of this disease.
  • [MeSH-major] Central Nervous System Vascular Malformations / radiography. Hematoma / radiography. Intracranial Hemorrhages / radiography. Pineal Gland
  • [MeSH-minor] Adult. Angiography. Diplopia / diagnosis. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 16385664.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2810602
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33. Zajac A, Skowronek-Bała B, Wesołowska E, Kaciński M: [The pineal cyst in children with different central nervous system diseases]. Przegl Lek; 2010;67(11):1136-9
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  • [Title] [The pineal cyst in children with different central nervous system diseases].
  • BACKGROUND: In the group of adult patients being diagnosed from different neurological complaints frequency of pineal cyst occurrence is estimated at 0,1-4,9%.
  • However, neoplastic lesions may also localize in pineal cyst.
  • AIM OF THE STUDY: Characterization of pineal cysts found in children diagnosed from different neurological diseases.
  • MR examination with contrast (with the use of Siemens device 1,5 T) revealed lesions in pineal gland defined as pineal cysts.
  • In 24/45 children serum tumor markers AFP and betaHCG were determined.
  • RESULTS: The diameter of pineal cyst was between 3-10 mm in 40/45 children, 13 mm in 2 children and 11 mm in 3 children (most often 4-5 mm in 18 children).
  • In 1/3 of children included to the study, headaches were cause of brain MR examination.
  • In 15 children brain MR examination was performed due to epileptic paroxysmal events.
  • No positive values of tumor markers were found in any of examined children.
  • Pineal cysts are common structural lesions in children hospitalized from different neurological symptoms.
  • 2. Pineal cysts were usually found in children diagnosed because of headaches and epilepsy, and these were the most often final diagnosis.
  • 4. It is suspected that in majority of hospitalized patients pineal cyst was an incidental finding, with no association with clinical symptoms.
  • [MeSH-major] Biomarkers, Tumor / blood. Brain Diseases / epidemiology. Cysts / diagnosis. Cysts / epidemiology. Epilepsy / epidemiology. Headache / epidemiology. Pineal Gland

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  • (PMID = 21442964.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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34. Cipri S, Gangemi A, Cafarelli F, Messina G, Iacopino P, Al Sayyad S, Capua A, Comi M, Musitano A: Neuroendoscopic management of hydrocephalus secondary to midline and pineal lesions. J Neurosurg Sci; 2005 Sep;49(3):97-106
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendoscopic management of hydrocephalus secondary to midline and pineal lesions.
  • AIM: In patients with space-occupying lesions of the pineal region, increased intracranial pressure is due to direct compression of the sylvian aqueduct.
  • Based on results of the recent literature, neuroendoscopic management of obstructive hydrocephalus, secondary to tumors of the pineal gland, has gained a preeminent role respect to shunting procedures.
  • METHODS: In 14 select cases, hydrocephalus was secondary to midline and pineal lesions.
  • RESULTS: In our series, obstructive hydrocephalus secondary to midline and pineal lesions, was successful treated by neuroendoscopic approach alone in 9 cases, with an unremarkable course and good outcome, except in 1 case.
  • CONCLUSIONS: Neuroendoscopic approach affords a minimally invasive way to obtain 4 objectives by one-step surgical approach, such as resolution of obstructive hydrocephalus by endoscopic third ventriculostomy (ETV), cerebrospinal fluid sample to detect tumor markers and to perform cytological analysis, biopsy specimens and tissue diagnosis, associated to absence of shunt-related complications.
  • Therefore, in experienced hands, ETV should be the treatment of first choice, in cases of hydrocephalus secondary to lesions of the pineal gland.
  • [MeSH-major] Brain Neoplasms / complications. Hydrocephalus / etiology. Hydrocephalus / surgery. Neuroendoscopy. Pinealoma / complications
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Radiotherapy. Treatment Outcome. Ventriculoperitoneal Shunt. Ventriculostomy


35. Bednarek-Tupikowska G, Kuliczkowska-Płaksej J, Filus A, Bucyk B, Sokolska V: [A case of hypophyseal and pineal germinoma]. Endokrynol Pol; 2007 Sep-Oct;58(5):448-52
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  • [Title] [A case of hypophyseal and pineal germinoma].
  • MRI examination revealed an advanced hypophyseal and pineal gland tumor--germinoma.
  • The case puts on the necessity of a strict endocrinologic and radiologic follow-up in patients with idiopathic diabetes insipidus due to the possibility of existing potentially curable disease ie. intracranial tumor.
  • [MeSH-minor] Adult. Diabetes Insipidus / etiology. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18058742.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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36. Rejlekova K, Mego M, Rajec J, Sycova-Mila Z, Obertova J, Mardiak J: A rare case of malignant extragonadal germ cell tumor in the pineal region with an aggressive behaviour. Bratisl Lek Listy; 2009;110(5):296-7
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  • [Title] A rare case of malignant extragonadal germ cell tumor in the pineal region with an aggressive behaviour.
  • Though germ cell cancer is rare, it is the most common cancer in males between 20 and 40 years.
  • The primary site for the development of germ cell tumor is testes, but it can be seen in extragonadal locations as well.
  • Herein, we present a rare case of a 19-year-old patient with non/seminomatous extragonadal germ cell tumor in the pineal region with an aggressive behaviour, refractory to the combined therapy (surgery, radio- and chemotherapy).
  • [MeSH-major] Brain Neoplasms. Neoplasms, Germ Cell and Embryonal. Pineal Gland
  • [MeSH-minor] Adult. Humans. Male. Young Adult

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  • (PMID = 19507665.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovakia
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37. Martin-Blondel G, Rousseau A, Boch AL, Cacoub P, Sène D: Primary pineal melanoma with leptomeningeal spreading: case report and review of the literature. Clin Neuropathol; 2009 Sep-Oct;28(5):387-94
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  • [Title] Primary pineal melanoma with leptomeningeal spreading: case report and review of the literature.
  • OBJECTIVE: Primary melanomas of the pineal region are exceedingly rare and may be difficult to diagnose.
  • Magnetic resonance imaging revealed a pineal mass hyperintense on T1-weighted and isointense on T2-weighted sequences with diffuse leptomeningeal involvement and intense homogeneous contrast enhancement after gadolinium administration.
  • Histological examination showed a malignant melanocytic tumor cell proliferation expressing Melan-A, but not HMB-45 or S100 protein.
  • Even if we have no proof that the tumor actually arose in the pineal gland, based on the radiological and histological findings, and on the unremarkable dermatologic and ophthalmologic examinations, a primary pineal melanoma with leptomeningeal dissemination was diagnosed.
  • The patient received temozolomide-based chemotherapy followed by whole brain irradiation.
  • CONCLUSION: A diagnosis of pineal melanoma should be considered in the presence of a pineal mass that appears hyperintense on T1-weighted images and hypo- to isointense on T2-weighted images.
  • The diagnosis is provided by pathological examination of tumor specimens obtained at surgical resection or at leptomeningeal biopsy.
  • The prognosis of primary pineal melanoma is variable but meningeal spreading carries a dismal prognosis.
  • [MeSH-minor] Adult. Antigens, Neoplasm / metabolism. Brain / pathology. Brain / radiography. Brain / radionuclide imaging. Diagnosis, Differential. Fatal Outcome. Humans. MART-1 Antigen. Magnetic Resonance Imaging. Male. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. Prognosis. S100 Proteins / metabolism

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  • (PMID = 19788056.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
  • [Number-of-references] 20
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38. Winston AP, Barnard D, D'Souza G, Shad A, Sherlala K, Sidhu J, Singh SP: Pineal germinoma presenting as anorexia nervosa: Case report and review of the literature. Int J Eat Disord; 2006 Nov;39(7):606-8
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  • [Title] Pineal germinoma presenting as anorexia nervosa: Case report and review of the literature.
  • OBJECTIVE: Tumors of the hypothalamic-pineal region may present with a wide variety of symptoms, including disturbed eating.
  • We present a case where such a tumor was misdiagnosed as anorexia nervosa.
  • METHOD: We describe a case of pineal germinoma invading the hypothalamus, which was initially diagnosed as anorexia nervosa.
  • [MeSH-major] Anorexia Nervosa / diagnosis. Brain Neoplasms / pathology. Germinoma / pathology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Errors. Humans. Hypothalamus / pathology. Hypothalamus / radiation effects. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology

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  • [Copyright] (c) 2006 by Wiley Periodicals, Inc.
  • (PMID = 17041920.001).
  • [ISSN] 0276-3478
  • [Journal-full-title] The International journal of eating disorders
  • [ISO-abbreviation] Int J Eat Disord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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39. Pusztaszeri M, Pica A, Janzer R: Pineal parenchymal tumors of intermediate differentiation in adults: case report and literature review. Neuropathology; 2006 Apr;26(2):153-7
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  • [Title] Pineal parenchymal tumors of intermediate differentiation in adults: case report and literature review.
  • Pineal parenchymal tumors (PPT), including pineoblastomas, are very uncommon, especially in adults.
  • Because of the small number of reported cases, the histological and biological features of these tumors are still being defined, as is their optimal management.
  • Also, the pathological variability of these tumors makes it difficult to draw general conclusions about their behavior.
  • A 3.2 cm tumor in the pineal and tectal region with obstructive hydrocephalus was found in a 28-year-old female complaining of headaches and hypoesthesia of the right side of the face.
  • Stereotactic biopsy revealed a highly cellular tumor composed of small cells that contained little cytoplasm that were arranged in a diffuse pattern.
  • This paper discusses the pathological and biological features of these tumors and the treatment options available.
  • [MeSH-major] Brain Neoplasms / pathology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Cell Differentiation. Female. Humans. Immunohistochemistry. Neoadjuvant Therapy. Radiotherapy

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  • (PMID = 16708548.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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40. Lekovic GP, Gonzalez LF, Shetter AG, Porter RW, Smith KA, Brachman D, Spetzler RF: Role of Gamma Knife surgery in the management of pineal region tumors. Neurosurg Focus; 2007;23(6):E12
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  • [Title] Role of Gamma Knife surgery in the management of pineal region tumors.
  • OBJECT: Increasingly, radiosurgery is used to treat pineal region tumors, either as a primary treatment or as an adjunct to conventional radiation therapy.
  • The authors report their experience with Gamma Knife surgery (GKS) for the treatment of pineal region tumors.
  • Seventeen patients underwent GKS for nonmetastatic tumors of the pineal region.
  • In 2 of these 16 patients (one with an anaplastic astrocytoma, the other with a primitive neuroectodermal tumor), leptomeningeal and spinal spread of tumor developed despite control of the pineal lesions.
  • Conclusions Excellent control of pineal region brain tumors can be obtained with GKS when it is used in conjunction with surgery, conventional radiation therapy, or both.
  • [MeSH-major] Brain Neoplasms / surgery. Pineal Gland / surgery. Pinealoma / surgery. Radiosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Radiotherapy Dosage. Retrospective Studies

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  • (PMID = 18081477.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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41. Ida CM, Rodríguez FJ, Scheithauer BW, Kois N, Vanefsky M, Andersen BJ, Erickson B: Infiltrative chordoid meningioma of the pineal region: a study of 2 cases. Clin Neuropathol; 2007 May-Jun;26(3):111-8
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  • [Title] Infiltrative chordoid meningioma of the pineal region: a study of 2 cases.
  • OBJECTIVE: Meningiomas involving the pineal region are rare.
  • Herein we describe two cases of chordoid meningioma with histologic evidence of pineal gland infiltration.
  • RESULTS: the patients included a 44-year-old male and a 37-year-old female who presented with symptoms of intracranial tumor referable to the pineal region.
  • Histologically, the tumors were characterized by strands and cords ofmeningothelial cells arranged in a mucinous stroma.
  • Tumor cells demonstrated EMA and focal S100 protein immunoreactivity, but lacked cytokeratin AE1/AE3 and glial fibrillary acidic protein (GFAP) staining.
  • Synaptophysin and neurofilament protein highlighted the overrun pineal gland parenchyma.
  • CONCLUSIONS: Chordoid meningioma, although rare, may occur in the pineal region.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Pineal Gland / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male

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  • (PMID = 19157002.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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42. Chernov MF, Kamikawa S, Yamane F, Ishihara S, Kubo O, Hori T: Neurofiberscopic biopsy of tumors of the pineal region and posterior third ventricle: indications, technique, complications, and results. Neurosurgery; 2006 Aug;59(2):267-77; discussion 267-77
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  • [Title] Neurofiberscopic biopsy of tumors of the pineal region and posterior third ventricle: indications, technique, complications, and results.
  • OBJECTIVE: Evaluation of results of the neurofiberscopic biopsy of tumors of the pineal region and posterior third ventricle.
  • METHODS: From 2001 to 2004, 23 patients (mean age, 30.6 yr) with tumors located in the pineal region or posterior third ventricle underwent neurofiberscopic biopsy with simultaneous third ventriculostomy.
  • The procedure was indicated for verification of the histological diagnosis of the neoplasm, which was planned to be treated by radiotherapy and/or chemotherapy without open surgery (eight patients), establishment of the pathological diagnosis for further choice of the most appropriate treatment strategy (11 patients), differentiation of the recurrent neoplasm and radiation necrosis (two patients), and decompression of the large tumor-associated cyst (two patients).
  • On the long-term follow-up, delayed third ventricular stoma failure caused by tumor regrowth and scar formation was found in one patient, and dissemination of the malignant glioma through the subarachnoid space was found in another patient.
  • CONCLUSION: Neurofiberscopic biopsy represents a useful method for sampling of tumors of the pineal region and posterior third ventricle, which can be effectively used in both previously shunted and shunt-free patients.
  • [MeSH-major] Brain Neoplasms / diagnosis. Endoscopy / methods. Pineal Gland / pathology. Pinealoma / diagnosis. Third Ventricle / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy / adverse effects. Biopsy / instrumentation. Biopsy / methods. Female. Fever / etiology. Fever / physiopathology. Fiber Optic Technology / instrumentation. Fiber Optic Technology / methods. Fiber Optic Technology / standards. Germinoma / diagnosis. Germinoma / physiopathology. Germinoma / therapy. Glioma / diagnosis. Glioma / physiopathology. Glioma / therapy. Humans. Intraoperative Complications / etiology. Intraoperative Complications / physiopathology. Intraoperative Complications / prevention & control. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Predictive Value of Tests. Ventriculoperitoneal Shunt. Ventriculostomy / instrumentation. Ventriculostomy / methods

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  • (PMID = 16883167.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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43. Reyns N, Hayashi M, Chinot O, Manera L, Péragut JC, Blond S, Régis J: The role of Gamma Knife radiosurgery in the treatment of pineal parenchymal tumours. Acta Neurochir (Wien); 2006 Jan;148(1):5-11; discussion 11
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  • [Title] The role of Gamma Knife radiosurgery in the treatment of pineal parenchymal tumours.
  • OBJECT: The aim of this study was to document the possible role of Gamma Knife radiosurgery, suitable for the treatment of deep and well limited tumors, in the management of pineal parenchymal tumors (PPT).
  • The marginal dose to these tumors ranged from 11 to 20 Gy (mean 15 Gy).
  • RESULTS: With a mean follow-up of 34 months (range 6 to 88), all tumors responded to treatment and disappeared or ceased growing.
  • Two patients with pineoblastoma had tumor size progression out of the initial target requiring several radiosurgery procedures.
  • Two patients with pineoblastoma died because of carcinomatous meningitis or tumor size progression.
  • It should have a role in multimodality therapy which includes microsurgical resection, fractionated radiotherapy and chemotherapy for the management of malignant pineal tumors.
  • [MeSH-major] Brain Neoplasms / surgery. Pineal Gland. Pinealoma / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 16172830.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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44. Stoiber EM, Schaible B, Herfarth K, Schulz-Ertner D, Huber PE, Debus J, Oertel S: Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003--a single institution's experience. Radiat Oncol; 2010;5:122
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  • [Title] Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003--a single institution's experience.
  • BACKGROUND: To evaluate the effectivity of fractionated radiotherapy in adolescent and adult patients with pineal parenchymal tumors (PPT).
  • All patients underwent radiotherapy on the primary tumor site with a median total dose of 54 Gy.
  • In 9 patients with primary PB treatment included whole brain irradiation (3 patients) or irradiation of the craniospinal axis (6 patients) with a median total dose of 35 Gy.
  • Among 5 PB patients treated with radiotherapy without chemotherapy, 3 developed local or spinal tumor recurrence.
  • As PPT are very rare tumors, treatment within multi-institutional trials remains necessary.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Pineal Gland / pathology. Pinealoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Male. Middle Aged. Radiation Injuries / epidemiology. Radiotherapy / adverse effects. Radiotherapy / methods. Recurrence. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 21184689.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3019157
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45. Pontes GN, Cardoso EC, Carneiro-Sampaio MM, Markus RP: Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production. J Pineal Res; 2007 Nov;43(4):365-71
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  • [Title] Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production.
  • Previous works suggest that, in the beginning of a defense response, the increase in circulating tumor necrosis factor-alpha (TNF-alpha) leads to a transient block of nocturnal melatonin production and promotes a disruption of internal time organization.
  • The present paper supports the hypothesis of a cross-talk between the pineal gland and the immune system, which could represent a putative immune-pineal axis.
  • [MeSH-major] Cytokines / metabolism. Melatonin / metabolism. Pineal Gland / immunology. Tumor Necrosis Factor-alpha / metabolism
  • [MeSH-minor] Adolescent. Adult. Cesarean Section. Circadian Rhythm. Colostrum / immunology. Colostrum / metabolism. Female. Humans. Interferon-gamma / immunology. Interferon-gamma / metabolism. Interleukin-10 / immunology. Interleukin-10 / metabolism. Interleukin-12 / immunology. Interleukin-12 / metabolism. Interleukin-2 / immunology. Interleukin-2 / metabolism. Interleukin-4 / immunology. Interleukin-4 / metabolism. Interleukin-5 / immunology. Interleukin-5 / metabolism. Milk, Human / immunology. Milk, Human / metabolism. Pregnancy

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  • (PMID = 17910605.001).
  • [ISSN] 0742-3098
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-2; 0 / Interleukin-5; 0 / Tumor Necrosis Factor-alpha; 130068-27-8 / Interleukin-10; 187348-17-0 / Interleukin-12; 207137-56-2 / Interleukin-4; 82115-62-6 / Interferon-gamma; JL5DK93RCL / Melatonin
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46. Desai KI, Nadkarni TD, Fattepurkar SC, Goel AH: Pineal epidermoid cysts: a study of 24 cases. Surg Neurol; 2006 Feb;65(2):124-9
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  • [Title] Pineal epidermoid cysts: a study of 24 cases.
  • BACKGROUND: A retrospective analysis of clinical features and management strategy in 24 cases of epidermoids in the pineal region is done.
  • METHODS: Twenty-four patients having epidermoids in the pineal region were surgically treated in our department during an 11-year period (1992 up to 2003).
  • In one patient, the tumor was removed in 2 stages, first by the infratentorial-supracerebellar approach and subsequently by the interhemispheric posterior parietooccipital surgical approach.
  • Total excision of the solid part of the tumor and the capsule was achieved in 6 patients.
  • In 13 cases, the solid part of the tumor was completely resected, but at least, a part of the tumor capsule was left behind.
  • In 5 cases, a part of the solid portion of the tumor was either deliberately or inadvertently left behind.
  • Incomplete tumor resection was primarily due to adhesions of the capsule to large veins in the region, dissection around which was considered hazardous, and extensive and invasive nature of extension of the tumor.
  • During the period of follow-up, one patient had asymptomatic growth of the residual tumor after 6 years of surgery.
  • One patient with residual tumor continued to get generalized seizures.
  • CONCLUSION: Radical surgery for pineal region epidermoid tumors is associated with an excellent immediate postoperative and long-term outcome.
  • [MeSH-major] Brain Diseases / radiography. Brain Diseases / surgery. Epidermal Cyst / radiography. Epidermal Cyst / surgery. Pineal Gland / radiography. Pineal Gland / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Recurrence. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16427400.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Kanamori M, Kumabe T, Tominaga T: Is histological diagnosis necessary to start treatment for germ cell tumours in the pineal region? J Clin Neurosci; 2008 Sep;15(9):978-87
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  • [Title] Is histological diagnosis necessary to start treatment for germ cell tumours in the pineal region?
  • The significance of histological diagnosis was retrospectively investigated in the treatment of 79 consecutive patients with pineal region tumours.
  • Histological diagnoses were consistent with clinical diagnoses in 38 out of 39 patients with germ cell tumours and in all eight patients with non-germ cell tumours.
  • Forty-one patients were treated under a clinical diagnosis of pineal germ cell tumour using neoadjuvant chemotherapy and radiation therapy without histological verification.
  • Most cases of pineal germ cell tumour could be identified on the basis of clinical findings only, and could be treated appropriately using neoadjuvant chemotherapy and radiation therapy without histological diagnosis.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / therapy. Pineal Gland / pathology. Pinealoma / diagnosis. Pinealoma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Antineoplastic Protocols / standards. Biomarkers, Tumor / analysis. Child. Child, Preschool. Decision Support Techniques. Female. Humans. Infant. Male. Middle Aged. Neurosurgical Procedures. Predictive Value of Tests. Radiotherapy / methods. Retrospective Studies. Teratoma / diagnosis. Teratoma / metabolism. Teratoma / therapy. Treatment Outcome

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  • (PMID = 18617412.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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48. Kumar P, Tatke M, Sharma A, Singh D: Histological analysis of lesions of the pineal region: a retrospective study of 12 years. Pathol Res Pract; 2006;202(2):85-92
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  • [Title] Histological analysis of lesions of the pineal region: a retrospective study of 12 years.
  • Various types of tumors and non-tumor lesions arise in the pineal region.
  • This study summarizes the experience the authors have gained with 54 lesions of the pineal region over the last 12 years.
  • Out of these 54 cases, four were non-tumor lesions.
  • Of the 50 tumors, pineal parenchymal tumors (PPTs) were most common (42% (21/54)), followed by gliomas (40% (20/54)).
  • The other tumors included germ cell tumors (4/54), meningiomas (2/54), craniopharyngiomas (2/54), and choroid plexus papilloma (1/54).
  • The non-tumor lesions were epidermoid cysts (2/54), tuberculous abscess (1/54), and cysticercosis (1/54).
  • Glial fibrillary acidic protein (GFAP) stained only the reactive astrocytes in these tumors except two cases of pineoblastoma, which showed GFAP positivity in some tumor cells, indicating glial differentiation.
  • There are very few studies of pineal lesions, and there is no study from India in the indexed literature.
  • [MeSH-major] Brain Neoplasms / pathology. Pinealoma / pathology
  • [MeSH-minor] Adolescent. Adult. Cell Differentiation. Child. Child, Preschool. Epidermal Cyst / pathology. Glioma / pathology. Humans. Infant. Male. Middle Aged. Neoplasms, Germ Cell and Embryonal / pathology. Pineal Gland. Retrospective Studies

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  • (PMID = 16413691.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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49. Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, Komori T, Tanaka Y, Nakazato Y, Akimoto J, Tanaka M, Okada Y, Saito S: Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors. J Neuropathol Exp Neurol; 2010 May;69(5):498-510
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  • [Title] Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.
  • Pineal parenchymal tumor (PPT) cells usually show immunoreactivity for synaptophysin, neuron-specific enolase, neurofilament protein, class III beta-tubulin, tau protein, PGP9.5, chromogranin, serotonin, retinal S-antigen, and rhodopsin, but these markers are not specific for PPTs.
  • Melatonin is produced and secreted mainly bypineal parenchymal cells; hydroxyindole-O-methyltransferase (HIOMT) catalyzes the final reaction in melatonin biosynthesis.
  • We hypothesized that HIOMT could serve as a tumor marker of PPTs, and we investigated HIOMT localization and HIOMT expression in samples of normal human tissue and in PPTs, primitive neuroectodermal tumors, and medulloblastomas.
  • In normal tissue, HIOMT was expressed in retinal cells, pineal parenchymal cells, neurons of the Edinger-Westphal nucleus, microglia, macrophages, thyroid follicular epithelium, principal and oxyphil cells of parathyroid gland, adrenal cortical cells, hepatic parenchymal cells, renal tubule epithelium, and enteroendocrine cells of stomach and duodenum.
  • The proportions of HIOMT-immunoreactive cells successively decreased in the following tumors: pineocytoma, pineal parenchymal tumor of intermediate differentiation, and pineoblastoma.
  • A few HIOMT-immunoreactive cells were observed in one of 6 primitive neuroectodermal tumors and 23 of 42 medulloblastomas.
  • [MeSH-major] Acetylserotonin O-Methyltransferase / metabolism. Brain Neoplasms / pathology. Central Nervous System / enzymology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Animals. Arrestin / metabolism. Cell Line, Tumor. Child. Child, Preschool. Eye Proteins / genetics. Eye Proteins / metabolism. Female. Green Fluorescent Proteins / genetics. Humans. Infant. Male. Middle Aged. Nerve Tissue Proteins / metabolism. Neurons / metabolism. Plant Lectins / metabolism. RNA, Messenger / metabolism. Retina / pathology. Transfection / methods

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  • (PMID = 20418777.001).
  • [ISSN] 1554-6578
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arrestin; 0 / Eye Proteins; 0 / Nerve Tissue Proteins; 0 / Plant Lectins; 0 / RNA, Messenger; 0 / Ricinus communis agglutinin-1; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 2.1.1.4 / Acetylserotonin O-Methyltransferase
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50. Nayar VV, Benveniste RJ, Lang FF: A novel technique for planning surgical approaches to the pineal region by using external cranial landmarks. J Neurosurg; 2010 Nov;113(5):1000-3

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  • [Title] A novel technique for planning surgical approaches to the pineal region by using external cranial landmarks.
  • OBJECT: The infratentorial supracerebellar approach to the pineal region presents special challenges during patient positioning.
  • Therefore, a reliable method of positioning based on external, easily identifiable landmarks to estimate the surgical trajectory along the straight sinus toward the pineal region is needed.
  • The distance from the intersection point to the bregma was not statistically significantly different in younger or older patients, or in patients with or without tumors involving the pineal region.
  • [MeSH-major] Neurosurgical Procedures / methods. Patient Positioning. Pineal Gland / surgery. Skull / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 20397897.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Lissoni P, Brivio F, Fumagalli L, Messina G, Vigoré L, Parolini D, Colciago M, Rovelli F: Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors. Anticancer Res; 2008 Mar-Apr;28(2B):1377-81
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  • [Title] Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors.
  • BACKGROUND: Anticancer immunity is under psychoneuroendocrine regulation, mainly via the pineal gland and brain opioid system, which may stimulate and inhibit antitumor immunity respectively.
  • Cancer-related immuno-suppression does not depend only on functional damage of immune cells, but also on alterations of systems responsible for the neuroimmunomodulation, the most frequent of wich is a decline in blood levels of the pineal hormone melatonin (MLT).
  • PATIENTS AND METHODS: A study was performed to evaluate the influence of an exogenous administration of MLT alone or MLT plus subcutaneous (SC) low-dose interleukin-2 on tumor progression and survival time in patients with untreatable metastatic solid tumors.
  • The study included 846 patients with metastatic solid tumor (non-small cell lung cancer or gastrointestinal tract tumors) randomized to receive the best supportive care only, supportive care plus MLT (20 mg/day, orally in the evening), or MLT plus SC low-dose IL-2 (3 MIU/day for 5 days/week, for 4 consecutive weeks).
  • The association of lL-2 with MLT provided a further improvement in the percentage of tumor regressions and of 3-year survival with respect to MLT alone.
  • CONCLUSION: The administration of IL-2 and the pineal hormone MLT may induce control of neolplastic growth and a prolonged survival time in patients with metastatic solid tumors, for whom no other conventional anticancer therapy is available.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Gastrointestinal Neoplasms / drug therapy. Interleukin-2 / administration & dosage. Lung Neoplasms / drug therapy. Melatonin / administration & dosage. Palliative Care / methods
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 18505083.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Interleukin-2; JL5DK93RCL / Melatonin
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52. Kamoshima Y, Sawamura Y, Iwasaki M, Iwasaki Y, Sugiyama K: Metachronous mature teratoma in the corpus callosum occurring 12 years after a pineal germinoma. J Neurosurg; 2008 Jul;109(1):126-9
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  • [Title] Metachronous mature teratoma in the corpus callosum occurring 12 years after a pineal germinoma.
  • The authors report a metachronous germ cell tumor with different histological type occurring 12 years after resection of a pineal germinoma.
  • Histological examination of the original tumor revealed germinoma without any other component of germ cell tumor, and the patient underwent chemotherapy followed by 24 Gy of localized irradiation.
  • Two courses of chemotherapy were administered, but the tumor size remained stable.
  • A second operation was performed and this second tumor was completely removed.
  • The second tumor was considered as a metachronous mature teratoma rather than a recurrence of the original germinoma.
  • To the authors' knowledge, this combination of metachronous germ cell tumor has not previously been reported in the literature.
  • [MeSH-major] Brain Neoplasms / pathology. Corpus Callosum. Neoplasms, Second Primary / pathology. Pineal Gland. Pinealoma / pathology. Teratoma / pathology
  • [MeSH-minor] Adult. Humans. Male. Time Factors

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  • (PMID = 18590442.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Pastel DA, Mamourian AC, Duhaime AC: Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy. J Neurosurg Pediatr; 2009 Jul;4(1):81-4
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  • [Title] Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy.
  • OBJECT: In this paper, the authors' goal was to determine whether benign pineal cysts have smooth walls or internal structure on high-resolution MR imaging and to evaluate their imaging characteristics on FLAIR images.
  • METHODS: The authors retrospectively reviewed the MR imaging findings in 60 consecutive patients who were reported to have pineal cysts over a 19-month period.
  • Of these 60 patients, 24 with stable follow-up imaging or pathological proof of a pineal cyst were included in this study.
  • Of the 10 cases with FIESTA, 6 had evidence of internal structure within the pineal cyst.
  • CONCLUSIONS: Although the presence of a thin wall supports the diagnosis of a benign pineal cyst, fine internal septations or small internal cysts are common on high-resolution MR imaging and this finding should not be considered evidence of an underlying tumor.
  • It is typical for pineal cysts to have relaxation times that differ from CSF as determined by FLAIR imaging.
  • [MeSH-major] Brain Neoplasms / pathology. Cysts / pathology. Magnetic Resonance Imaging. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Image Processing, Computer-Assisted. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 19569915.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Cho SH, Hong SC, Lee JH, Cho GJ, Park HT, Kim T, Kim YT, Lee KW, Kim SH: Total laparoscopic resection of primary large retroperitoneal teratoma resembling an ovarian tumor in an adult. J Minim Invasive Gynecol; 2008 May-Jun;15(3):384-6
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  • [Title] Total laparoscopic resection of primary large retroperitoneal teratoma resembling an ovarian tumor in an adult.
  • Whereas most teratomas occur in the ovaries and testes of adolescents, they can be found in midline structures such as sacrococcygeum (congenitally), anterior mediastinum, retroperitoneum, and the pineal gland.
  • A 27-year-old woman was referred to our hospital because of an incidentally found pelvic mass, considered to be an ovarian tumor by ultrasonography.
  • Computed tomography strongly suggested a retroperitoneal cystic tumor because of anterior displacement of retroperitoneal organs.
  • In this case, despite a large tumor size and its approaching the rectum, total laparoscopic resection was the most feasible surgical choice.
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18439519.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Ghosal N, Furtado SV, Hegde AS: Pinealoblastoma with prominent retinoblastic differentiation: an unusual case in an adult. Neuropathology; 2010 Aug;30(4):439-42
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  • [Title] Pinealoblastoma with prominent retinoblastic differentiation: an unusual case in an adult.
  • Paraffin section of the tumor showed a primitive neuroectodermal tumor with numerous Flexner-Wintersteiner rosettes and the tumor cells were strongly positive for synaptophysin and negative for GFAP, S-100 protein and epithelial membrane antigen.
  • This is the first case in the literature of a sporadic case of pinealoblastoma with prominent retinoblastic differentiation as evidenced histomorphologically by the presence of numerous Flexner-Wintersteiner rosettes in an adult female.
  • [MeSH-major] Brain Neoplasms / pathology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Synaptophysin / biosynthesis

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  • (PMID = 20051015.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Synaptophysin
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56. DeBoer R, Batjer H, Marymont M, Goldman S, Walker M, Gottardi-Littell N, Raizer J: Response of an adult patient with pineoblastoma to vorinostat and retinoic acid. J Neurooncol; 2009 Nov;95(2):289-292
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  • [Title] Response of an adult patient with pineoblastoma to vorinostat and retinoic acid.
  • We report the case of an adult patient with pineoblastoma (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid.
  • This regimen was used to treat bulky residual tumor that persisted despite radiation therapy (RT) and two cycles of cytotoxic chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Pineal Gland. Pinealoma / drug therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Hydroxamic Acids / administration & dosage. Male. Prognosis. Radiotherapy Dosage. Treatment Outcome. Tretinoin / administration & dosage

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  • [Cites] Neurosurgery. 2002 Jul;51(1):44-55; discussion 55-6 [12182434.001]
  • [Cites] Oncol Rep. 2006 Nov;16(5):1047-52 [17016591.001]
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  • (PMID = 19506816.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydroxamic Acids; 5688UTC01R / Tretinoin; 58IFB293JI / vorinostat
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57. Lee JY, Wakabayashi T, Yoshida J: Management and survival of pineoblastoma: an analysis of 34 adults from the brain tumor registry of Japan. Neurol Med Chir (Tokyo); 2005 Mar;45(3):132-41; discussion 141-2
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  • [Title] Management and survival of pineoblastoma: an analysis of 34 adults from the brain tumor registry of Japan.
  • Pineoblastoma is a rare tumor in adults, and factors influencing survival are poorly understood.
  • Data from the Brain Tumor Registry of Japan (BTRJ) was analyzed to examine patient, tumor, and treatment characteristics associated with increased survival in adults with pineoblastomas.
  • Data were extracted on demographics, presentation, tumor characteristics, treatments, and outcomes.
  • Adult pineoblastoma patients have poor survival prognosis.
  • [MeSH-major] Brain Neoplasms / mortality. Brain Neoplasms / therapy. Pineal Gland / pathology. Pinealoma / mortality. Pinealoma / therapy. Registries
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Cohort Studies. Female. Humans. Japan / epidemiology. Male. Middle Aged. Models, Statistical. Neurosurgical Procedures / statistics & numerical data. Prognosis. Radiotherapy / statistics & numerical data. Regression Analysis. Retrospective Studies. Sex Factors. Survival Rate. Treatment Outcome

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  • (PMID = 15782004.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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58. Delmaire C, Gauvrit JY, Hajj E, Ares GS, Ayachi M, Reyns N, Dubois F, Pruvo JP: [Midline tumors of the central nervous system]. J Radiol; 2006 Jun;87(6 Pt 2):764-78
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  • [Title] [Midline tumors of the central nervous system].
  • The anatomy of the supratentoriel midline structures of the brain is complex: corpus callosum, third ventricle, trigone, choroid plexus, pineal gland, falx cerebri.
  • Different types of tumors can arise from these structures including tumors of the trigone and septum, tumors of the falx, third ventricular tumors and pinal region tumors.
  • These tumors share similar features: minimal clinical symptoms despite their occasional large size, mild non-specific intracranial hypertension syndrome, value of MRI for depiction of tumor location, stereotactic biopsy, relative difficulty of surgical management.
  • [MeSH-major] Brain Neoplasms / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Cerebral Ventricle Neoplasms / diagnosis. Female. Humans. Pineal Gland

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  • (PMID = 16778746.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 30
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59. Gomes FL, França LR, Zymberg ST, Cavalheiro S: Central neurocytomas of uncommon locations: report of two cases. Arq Neuropsiquiatr; 2006 Dec;64(4):1015-8
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  • We report two patients with central neurocytomas at an uncommon location in the brain.
  • The first, a 58-year-old man presenting with signs and symptoms of increased intracranial pressure, had a tumor located at the pineal region.
  • The second, a 21-year-old woman with tumor in the aqueductal region had worsening migraine-like headaches and diplopia.
  • Both patients had obstructive hydrocephalus treated by neuroendoscopic third ventriculostomy and biopsy of the tumors.
  • We conclude that neurocytomas should be considered in the differential diagnosis of tumors located in the pineal and aqueductal regions.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebral Aqueduct / pathology. Neurocytoma / pathology. Pineal Gland / pathology
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Ventriculostomy

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  • (PMID = 17221015.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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60. Birbilis TA, Matis GK, Eleftheriadis SG, Theodoropoulou EN, Sivridis E: Spinal metastasis of glioblastoma multiforme: an uncommon suspect? Spine (Phila Pa 1976); 2010 Apr 1;35(7):E264-9
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  • SUMMARY OF BACKGROUND DATA: GBM constitutes the most common adult malignant brain tumor with poor prognosis.
  • METHODS: We hereby present a case of a 57-year-old woman with a history of pineal GBM treated by stereotactic biopsy, chemotherapy, and radiotherapy, readmitted 38 months later due to gait disturbance, spastic paraparesis, edema of lower limbs, bilateral positive Babinski response, and loss of bladder control.
  • CONCLUSION: Spinal metastases should be commonly suspected in patients with a history of intracranial GBM who complain about symptoms not explained by the primary lesion.Glioblastoma multiforme (GBM) was first described by Rudolph Virchow in 1863 and represents the most common and most malignant tumor of the cerebral hemispheres, usually arising between the ages of 40 and 60 years.
  • [MeSH-major] Brain Neoplasms / pathology. Glioblastoma / secondary. Pineal Gland / pathology. Spinal Neoplasms / secondary

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  • (PMID = 20195200.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Lv XF, Qiu YW, Zhang XL, Han LJ, Qiu SJ, Xiong W, Wen G, Zhang YZ, Zhang J: Primary intracranial choriocarcinoma: MR imaging findings. AJNR Am J Neuroradiol; 2010 Nov;31(10):1994-8
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  • All tumors were located within the pineal (n = 6) or suprasellar (n = 1) regions.
  • These MR imaging findings, combined with patient age and serum β-HCG levels, may prove helpful in distinguishing PICCC from the more common primary brain tumors, thereby avoiding biopsy of this highly vascular tumor.
  • [MeSH-minor] Adolescent. Calcinosis / radiography. Cerebral Hemorrhage / pathology. Child. Chorionic Gonadotropin, beta Subunit, Human / blood. Cysts / pathology. Female. Fibrosis. Humans. Male. Necrosis. Pineal Gland / pathology. Retrospective Studies. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20616180.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
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62. Sugiyama K, Yamasaki F, Kurisu K, Kenjo M: Quality of life of extremely long-time germinoma survivors mainly treated with radiotherapy. Prog Neurol Surg; 2009;23:130-9
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  • They were 41 males and 11 females; the tumor location was pineal in 20, neurohypophyseal in 15, pineal and neurohypophyseal in 11 patients; in 6 it was located in another region.
  • RESULTS: In 6 patients, the tumor recurred; 6 other patients developed second tumors while in complete remission from the first tumor.
  • The main cause of 12 deaths was complications due to primary tumor invasion, the initial treatment, or tumor recurrence rather than tumor progression.
  • Of 44 patients, 6 were married and 3 males with solitary pineal tumors were fathers.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Germinoma / radiotherapy. Pineal Gland. Pinealoma / radiotherapy. Quality of Life
  • [MeSH-minor] Adolescent. Adult. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local / mortality. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19329867.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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63. Song JH, Kong DS, Shin HJ: Feasibility of neuroendoscopic biopsy of pediatric brain tumors. Childs Nerv Syst; 2010 Nov;26(11):1593-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Feasibility of neuroendoscopic biopsy of pediatric brain tumors.
  • PURPOSE: The purpose of this study was to investigate the potential value of neuroendoscopic biopsies in pediatric patients with peri- or intraventricular tumors.
  • METHODS: From 2001 to 2008, 49 pediatric patients (mean age, 12.16 years) with tumors located in the intraventricular or paraventricular areas underwent neuroendoscopic biopsy, with or without simultaneous endoscopic third ventriculostomy.
  • The tumor location included the pineal gland (n = 28), thalamus (n = 7), intraventricle (n = 3), hypothalamus (n = 3), suprasellar area (n = 2), and diffuse multifocal area (n = 3).
  • Tumor tissue specimens were undiagnostic in two patients (4.1%).
  • One patient experienced postoperative tumor bleeding requiring emergent operation.
  • CONCLUSION: Neuroendoscopic biopsy can be considered as the first choice for tissue sampling of periventricular and intraventricular tumors with acceptable risks.
  • [MeSH-major] Biopsy / methods. Brain Neoplasms / pathology. Cerebral Ventricle Neoplasms / pathology. Hypothalamic Neoplasms / pathology. Neuroendoscopy / methods. Pinealoma / pathology. Thalamic Diseases / pathology
  • [MeSH-minor] Adolescent. Cerebral Ventricles / pathology. Child. Child, Preschool. Feasibility Studies. Female. Humans. Hypothalamus / pathology. Infant. Male. Pineal Gland / pathology. Postoperative Complications / etiology. Thalamus / pathology. Young Adult

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  • (PMID = 20390421.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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64. Broggi M, Darbar A, Teo C: The value of endoscopy in the total resection of pineocytomas. Neurosurgery; 2010 Sep;67(3 Suppl Operative):ons159-65
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  • BACKGROUND: Pineocytomas are rare pineal region tumors.
  • The endoscope was used at various times throughout the case and consistently at the end to evaluate any possible residual tumor.
  • In 6 cases (40%), the endoscope was able to detect residual tumor located either behind the Vein of Galen or attached to the undersurface of the corpus callosum.
  • Residual tumor was then resected using a 30 degrees endoscope and dedicated angled endoscopic instruments.
  • With total removal of these histologically benign tumors patients may enjoy extended progression-free survival without adjuvant radiotherapy.
  • [MeSH-major] Brain Neoplasms / surgery. Endoscopy / methods. Neurosurgery / methods. Pineal Gland / surgery. Pinealoma / surgery. Ventriculostomy / methods
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Longitudinal Studies. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Third Ventricle / surgery

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  • (PMID = 20679933.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Terra R, Luo H, Qiao X, Wu J: Tissue-specific expression of B-cell translocation gene 2 (BTG2) and its function in T-cell immune responses in a transgenic mouse model. Int Immunol; 2008 Mar;20(3):317-26
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  • [Title] Tissue-specific expression of B-cell translocation gene 2 (BTG2) and its function in T-cell immune responses in a transgenic mouse model.
  • B-cell translocation gene 2 (BTG2) belongs to the anti-proliferative gene family.
  • According to previous in vitro studies, BTG2 overexpression leads to delayed cell cycling.
  • In situ hybridization showed that BTG2 was expressed at high levels in the central nervous system, liver, stomach, thymus, spleen, skin, adrenal gland, pituitary gland and salivary glands during embryonic days (E10-E17), postnatal days (P1 and P10) and adult stages.
  • Expression was observed in organs and tissues from adult mice with and without a robust proliferation program.
  • BTG2 expression was induced after in vitro T-cell receptor stimulation in T cells using anti-CD3 antibodies.
  • However, transgenic (Tg) mice with actin promoter-driven expression of BTG2 showed normal in vitro and in vivo T-cell responses, such as thymus development, T-cell activation marker expression, T-cell proliferation and migration, as well as in vivo delayed-type hypersensitivity reactions.
  • Although BTG2 was expressed in the suprachiasmatic nucleus and pineal gland in the brain, BTG2 Tg mice had no abnormal circadian behavior.
  • [MeSH-minor] Animals. Apoptosis. Circadian Rhythm. Genes, Tumor Suppressor. Lymph Nodes / cytology. Mice. Mice, Transgenic. RNA, Messenger / metabolism. Spleen / cytology. Thymus Gland / cytology. Tumor Suppressor Proteins

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  • (PMID = 18195048.001).
  • [ISSN] 1460-2377
  • [Journal-full-title] International immunology
  • [ISO-abbreviation] Int. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immediate-Early Proteins; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins; 141490-22-4 / BTG2 protein, human
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66. Ohta Y, Suzuki T, Tonoike T, Hamatani S, Ohike N, Shiokawa A, Kushima M, Ota H: Two cases of intracranial germinoma showing a cell arrangement mimicking carcinoma. Diagn Cytopathol; 2010 Feb;38(2):132-6
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  • [Title] Two cases of intracranial germinoma showing a cell arrangement mimicking carcinoma.
  • Tumors of germ cell origin uncommonly arise in extragonadal sites.
  • Cytologically, not only single tumor cells or loosely connective tumor cells but also closely packed clusters of cells and pair cells were recognized.
  • Immunocytochemically, almost all tumor cells were immunoreactive for M2A, placental alkaline phosphatase, and c-kit.
  • Therefore, Cytopathologists should be aware that tumor cell clusters, mimicking carcinoma might appear in cytological specimens of intracranial germinomas.
  • Although immunocytochemical analysis assists in correct diagnosis, some cell clusters showing cytokeratin immunoreactivity does not become the basis for the diagnosis of metastatic carcinoma.
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma / pathology. Germinoma / pathology. Pineal Gland / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 20073098.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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67. Lee D, Suh YL: Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute. Virchows Arch; 2010 Sep;457(3):347-57
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  • [Title] Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute.
  • This study was undertaken to document the clinicopathologic characteristics of histologically verified, primary intracranial germ cell tumors (GCTs), determine treatment outcomes, and to identify prognostic factors.
  • Germinomas and malignant non-germinomatous germ cell tumors were most prevalent in the pineal gland, suprasellar region, and basal ganglia, whereas teratomas dominated at other sites.
  • Five-year OSs in patients with normal tumor marker (alphaFP or betaHCG) and patients with elevated marker were 85.26% and 66.96%, respectively (P = 0.0568).
  • Patients with elevated tumor marker levels may appear to have poorer OS independent of histology.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Kaplan-Meier Estimate. Korea. Male. Middle Aged. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 20652714.001).
  • [ISSN] 1432-2307
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  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
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68. Oztekin E, Mogulkoc R, Baltaci AK, Tiftik AM: The influence of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized rats. Acta Biol Hung; 2006 Sep;57(3):275-81
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  • The study was carried out on 42 adult, Spraque-Dawley strain female rats aged 6 months and weighing 200-250 grams.
  • [MeSH-major] Dietary Supplements. Estradiol / pharmacology. Melatonin / pharmacology. Ovary / physiology. Pineal Gland / physiology. Progesterone / pharmacology. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17048691.001).
  • [ISSN] 0236-5383
  • [Journal-full-title] Acta biologica Hungarica
  • [ISO-abbreviation] Acta. Biol. Hung.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Hormones; 0 / Tumor Necrosis Factor-alpha; 4G7DS2Q64Y / Progesterone; 4TI98Z838E / Estradiol; JL5DK93RCL / Melatonin
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69. Lewerenz J, Zurowski B, Jenicke L, Bäumer T, Lees AJ, Münchau A: Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy. Mov Disord; 2005 Aug;20(8):1071-5
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  • We report on a patient with a residual dorsorostral midbrain lesion after resection of a pineal gland tumor.
  • [MeSH-minor] Adult. Dopamine / metabolism. Humans. Magnetic Resonance Imaging / methods. Male. Neurosurgery / methods. Pinealoma / surgery. Substantia Nigra / metabolism. Substantia Nigra / pathology. Substantia Nigra / radionuclide imaging. Tomography, Emission-Computed, Single-Photon / methods

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  • [Copyright] Copyright 2005 Movement Disorder Society
  • (PMID = 15838851.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] VTD58H1Z2X / Dopamine
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70. Hinkes BG, von Hoff K, Deinlein F, Warmuth-Metz M, Soerensen N, Timmermann B, Mittler U, Urban C, Bode U, Pietsch T, Schlegel PG, Kortmann RD, Kuehl J, Rutkowski S: Childhood pineoblastoma: experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91. J Neurooncol; 2007 Jan;81(2):217-23
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  • The only patient with tumor progression during initial chemotherapy achieved complete remission with radiotherapy and is alive.
  • In contrast, all five young children died of tumor progression after a median OS of 0.9 years (PFS 0.6 years).
  • They had either metastatic disease (M1) and/or postoperative residual tumor.
  • Tumor biology may be more aggressive in younger children with PB, who presented more frequently with high-risk features at diagnosis and had poorer response rates to neoadjuvant postoperative chemotherapy.
  • [MeSH-major] Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy. Pineal Gland / pathology. Pinealoma / drug therapy. Pinealoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Prospective Studies. Treatment Outcome

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  • (PMID = 16941074.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. South M, Chiu JK, Teh BS, Bloch C, Schroeder TM, Paulino AC: Supine craniospinal irradiation using intrafractional junction shifts and field-in-field dose shaping: early experience at Methodist Hospital. Int J Radiat Oncol Biol Phys; 2008 Jun 1;71(2):477-83
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  • No failures occurred in the junctions of the spine-spine or brain-spine fields.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Cranial Irradiation / methods. Spinal Neoplasms / radiotherapy. Supine Position
  • [MeSH-minor] Adolescent. Adult. Atlanto-Occipital Joint. Cerebellar Neoplasms / radiotherapy. Child. Child, Preschool. Female. Humans. Male. Mechanics. Medulloblastoma / radiotherapy. Neoplasms, Germ Cell and Embryonal / radiotherapy. Particle Accelerators / instrumentation. Pineal Gland. Pinealoma / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Rhabdoid Tumor / radiotherapy. Spine. Teratoma / radiotherapy. Treatment Failure

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  • (PMID = 18164864.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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72. Jain N, Sood N, Wade P, Bandyopadhyay T: An unusual case of headache. Conn Med; 2008 Oct;72(9):525-6
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  • Pinealgland tumors comprise 0.5%-1% of adult brain tumors.
  • Pineoblastomas constitute less than half of these pineal gland tumors.
  • Due to the key anatomic location, these tumors produce hydrocephalus by pressing on the aqueduct of Sylvius.
  • These tumors can be detected by MRI and diagnosed on cytology of cerebrospinal fluid (CSF) showing blue round tumor cells with specific tumormarkers.
  • Combined chemo radiation therapy is the treatment for these tumors.
  • New onset persistent headaches are present in 50%-60% of intracranial tumors.
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18833868.001).
  • [ISSN] 0010-6178
  • [Journal-full-title] Connecticut medicine
  • [ISO-abbreviation] Conn Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Osuka S, Tsuboi K, Takano S, Ishikawa E, Matsushita A, Tokuuye K, Akine Y, Matsumura A: Long-term outcome of patients with intracranial germinoma. J Neurooncol; 2007 May;83(1):71-9
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  • Recurrence occurred in 5 patients, and 1 patient died of tumor.
  • Radiotherapy administered to the field encompassing the whole ventricle was essential for long-term tumor control.
  • [MeSH-major] Basal Ganglia. Brain Neoplasms / therapy. Germinoma / therapy. Pineal Gland. Pituitary Gland, Posterior
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Female. Humans. Incidence. Karnofsky Performance Status. Longitudinal Studies. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / mortality. Neurosurgical Procedures. Surveys and Questionnaires. Survival Analysis. Treatment Outcome

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  • (PMID = 17245622.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Douglas JG, Rockhill JK, Olson JM, Ellenbogen RG, Geyer JR: Cisplatin-based chemotherapy followed by focal, reduced-dose irradiation for pediatric primary central nervous system germinomas. J Pediatr Hematol Oncol; 2006 Jan;28(1):36-9
Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor location was suprasellar in four, the pineal region in three, and the third ventricle in one.
  • Two patients suffered marginal (at field edge) failures and both were salvaged using reinduction platinum-based chemotherapy followed by cranial spinal irradiation and a boost to the primary tumor.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy. Cisplatin / administration & dosage. Germinoma / drug therapy. Germinoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Pituitary Gland / physiology. Radiation Dosage. Retrospective Studies. Salvage Therapy. Survival Rate. Treatment Outcome

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  • (PMID = 16394891.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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75. Reisch N, Kühne-Eversmann L, Franke D, Beuschlein F, Mueller-Lisse UG, Reincke M, Seissler J: Intracranial germinoma as a very rare cause of panhypopituitarism in a 23-year old man. Exp Clin Endocrinol Diabetes; 2009 Jul;117(7):320-3
MedlinePlus Health Information. consumer health - Brain Tumors.

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  • MR imaging demonstrated contrast-enhancing mass lesions at the pineal gland, hypothalamus, and anterior horn of lateral ventricles bilaterally.
  • After radiotherapy with cranio-spinal radiation therapy with 24 Gy followed by two weeks of local tumor boost with 16 Gy, the posttherapy MRI scan indicated complete tumor removal.
  • This case demonstrates a very rare and potentially curable tumor as the cause of panhypopituitarism in adults.
  • [MeSH-major] Brain Neoplasms / complications. Germinoma / complications. Hypopituitarism / etiology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Nocturia / diagnosis. Polyuria / diagnosis. Young Adult

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  • (PMID = 19053025.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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76. Arita K, Hirano H, Sugiyama K, Kurisu K, Mamitsuka K: [Occipital transtentorial approach to pineal and juxta-pineal tumors: guidance for safe surgery of the pineal region tumor]. No Shinkei Geka; 2008 Mar;36(3):207-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Occipital transtentorial approach to pineal and juxta-pineal tumors: guidance for safe surgery of the pineal region tumor].
  • [MeSH-major] Neurosurgical Procedures / methods. Occipital Bone / surgery. Pineal Gland / surgery. Pinealoma / surgery
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Embryonal / surgery. Female. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18341010.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 18
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77. Coello AF, Torres A, Acebes JJ, Boluda S: Papillary tumor of the pineal region. Neurology; 2009 Aug 11;73(6):486
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary tumor of the pineal region.
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma, Papillary / pathology. Pineal Gland / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 19667327.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Murali R, Scheithauer BW, Chaseling RW, Owler BK, Ng T: Papillary tumour of the pineal region: cytological features and implications for intraoperative diagnosis. Pathology; 2010;42(5):474-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary tumour of the pineal region: cytological features and implications for intraoperative diagnosis.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Brain Neoplasms / diagnosis. Pineal Gland / pathology. Pinealoma / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Cell Nucleus / ultrastructure. Cytodiagnosis. Disease-Free Survival. Humans. Intraoperative Period. Magnetic Resonance Imaging. Male. Microscopy, Electron, Transmission. Microvilli / ultrastructure. Middle Aged

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  • (PMID = 20632826.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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