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1. Song H, Du Y, Sgouros G, Prideaux A, Frey E, Wahl RL: Therapeutic potential of 90Y- and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin's lymphoma with pulmonary involvement: a Monte Carlo-based dosimetric analysis. J Nucl Med; 2007 Jan;48(1):150-7
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  • [Title] Therapeutic potential of 90Y- and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin's lymphoma with pulmonary involvement: a Monte Carlo-based dosimetric analysis.
  • Pulmonary involvement is common in patients with non-Hodgkin's lymphoma (NHL). (90)Y- and (131)I-anti-CD20 antibodies (ibritumomab tiuxetan and tositumomab, respectively) have been approved for the treatment of refractory low-grade follicular NHL.
  • In this work, we used Monte Carlo-based dosimetry to compare the potential of (90)Y and (131)I, based purely on their emission properties, in targeted therapy for NHL lung metastases of various nodule sizes and tumor burdens.
  • METHODS: Lung metastases were simulated as spheres, with radii ranging from 0.2 to 5.0 cm, which were randomly distributed in a voxelized adult male lung phantom.
  • Dosimetric analysis was also performed for a lung-surface distribution of tumor nodules mimicking pleural metastatic disease.
  • CONCLUSION: Monte Carlo-based dosimetry was performed to compare the therapeutic potential of (90)Y and (131)I targeting of lung metastases in NHL patients. (131)I provided a therapeutic advantage over (90)Y, especially in tumors with radii less than 2.0 cm and at lower tumor burdens.
  • For both (90)Y- and (131)I-labeled antibodies, treatment is more efficacious when applied to metastatic NHL cases with lower tumor burdens. (131)I has advantages over (90)Y in treating smaller lung metastases.

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  • (PMID = 17204712.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA116477-01A1; United States / NCI NIH HHS / CA / R01 CA116477; United States / NCI NIH HHS / CA / R01 CA116477-01A1; United States / NCI NIH HHS / CA / R01CA116477
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 0 / Yttrium Radioisotopes
  • [Other-IDs] NLM/ NIHMS246413; NLM/ PMC2967041
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2. Wróel T, Mazur G, Dziegiel P, Jeleń M, Szuba A, Kuliczkowski K, Zabel M: Density of intranodal lymphatics and VEGF-C expression in B-cell lymphoma and reactive lymph nodes. Folia Histochem Cytobiol; 2006;44(1):43-7
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  • [Title] Density of intranodal lymphatics and VEGF-C expression in B-cell lymphoma and reactive lymph nodes.
  • Lymphatic vasculature in solid tumors may serve as the pathway for metastatic spread of the cancer to the regional lymph nodes and to distant organs.
  • The role of lymphangiogenesis in lymphoma spread and proliferation is not clearly established.
  • The aim of the present study was the evaluation of lymph node LYVE-1-positive lymphatic sinus density (LSD) and VEGF-C expression in patients with non-Hodgkin's lymphoma (nHL) and in reactive lymph nodes.
  • Sixty paraffin-embedded lymph nodes from newly diagnosed patients with B-cell nHL were evaluated.
  • Twelve lymph node biopsy specimens from adult patients with reactive lymphonodulitis were used as controls.
  • VEGF-C expression in lymph nodes of nHL patients was low and not significantly different from that in the control (p = 0.6).
  • Similarly we did not find differences in LSD in aggressive nHL and in indolent nHL (p=0.49).
  • The mean LSD in reactive lymph nodes was higher than in nHL (p = 0.03).
  • Higher LSD in reactive lymph nodes as compared to those of nHL patients suggests that lymphoma proliferation leads to the destruction of the existing lymphatics rather than to lymphangiogenesis within lymph nodes.
  • NHL are not associated with increased expression of VEGF-C nor increased LYVE-1-positive lymphatic sinuses density within lymph nodes.

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  • (PMID = 16584091.001).
  • [ISSN] 0239-8508
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / LYVE1 protein, human; 0 / Vascular Endothelial Growth Factor C; 0 / Vesicular Transport Proteins; EC 1.1.1.27 / L-Lactate Dehydrogenase
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3. Bruzzi JF, Macapinlac H, Tsimberidou AM, Truong MT, Keating MJ, Marom EM, Munden RF: Detection of Richter's transformation of chronic lymphocytic leukemia by PET/CT. J Nucl Med; 2006 Aug;47(8):1267-73
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  • Our objective was to evaluate the accuracy of PET/CT for the diagnosis of Richter's transformation of chronic lymphocytic leukemia (CLL) to diffuse large cell lymphoma.
  • Nine patients had false-positive PET/CT findings; in 3 of these patients, alternative malignancies were diagnosed (Hodgkin's disease; metastatic neuroendocrine carcinoma; non-small cell lung cancer).
  • For the specific diagnosis of Richter's transformation of CLL to diffuse large B-cell lymphoma, PET/CT had overall sensitivity, specificity, and positive and negative predictive values of 91%, 80%, and 53% and 97%, respectively.
  • CONCLUSION: PET/CT can detect Richter's transformation of CLL to diffuse large B-cell lymphoma with a high sensitivity and a high negative predictive value.
  • [MeSH-major] Cell Transformation, Neoplastic. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / radionuclide imaging. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large B-Cell, Diffuse / radionuclide imaging. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 16883004.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Hua F, Feng X, Guan Y, Zhao J, Huang Z: Non-Hodgkin's lymphoma of supraclavicular lymph nodes can mimic metastasis of breast cancer during chemotherapy on FDG PET/CT. Clin Nucl Med; 2009 Sep;34(9):594-5
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  • [Title] Non-Hodgkin's lymphoma of supraclavicular lymph nodes can mimic metastasis of breast cancer during chemotherapy on FDG PET/CT.
  • A metastatic lesion from the known breast cancer was considered.
  • However, biopsy results demonstrated that the abnormal activity in the right supraclavicular region is due to T-cell lymphoma.
  • [MeSH-major] Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Clavicle. Fluorodeoxyglucose F18. Lymphoma, Non-Hodgkin / diagnosis. Neoplasm Metastasis / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lymph Nodes / pathology. Lymph Nodes / radiography. Lymph Nodes / radionuclide imaging. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19692820.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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5. Jogai S, Al-Jassar A, Dey P, Adesina AO, Amanguno HG, Francis IM: Fine needle aspiration cytology of Hodgkin's lymphoma: A cytohistologic correlation study from a cancer center in Kuwait. Acta Cytol; 2006 Nov-Dec;50(6):656-62
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  • [Title] Fine needle aspiration cytology of Hodgkin's lymphoma: A cytohistologic correlation study from a cancer center in Kuwait.
  • OBJECTIVE: To assess the diagnostic accuracy offine needle aspiration cytology (FNAC) in the diagnosis of Hodgkin's lymphoma (HL).
  • Of these, 42 were correctly diagnosed as HL, and there was a discorrelation in 4 cases, comprising 3 cases of non-HL (T-cell-rich B-cell lymphoma [TCRBCL]-2, anaplastic large cell lymphoma-1) and 1 case of metastatic carcinoma.
  • Because of morphologic similarities, it is difficult to differentiate HL from anaplastic large cell lymphoma and TCRBCL on FNAC.
  • [MeSH-major] Hodgkin Disease / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Cancer Care Facilities. Child. Child, Preschool. Diagnosis, Differential. Diagnostic Errors. Female. Follow-Up Studies. Humans. Immunohistochemistry. Kuwait. Lymphoma, B-Cell / pathology. Lymphoma, Large-Cell, Anaplastic / pathology. Male. Middle Aged. Reproducibility of Results. T-Lymphocytes / pathology

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  • (PMID = 17152278.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. El-Sayed GM, Mohamed WS, Nouh MA, Moneer MM, El-Mahallawy HA: Viral genomes and antigen detection of hepatitis B and C viruses in involved lymph nodes of Egyptian non-Hodgkin's lymphoma patients. Egypt J Immunol; 2006;13(1):105-14
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  • [Title] Viral genomes and antigen detection of hepatitis B and C viruses in involved lymph nodes of Egyptian non-Hodgkin's lymphoma patients.
  • Several studies have suggested an association between Hepatitis C and B viruses (HCV and HBV) and non-Hodgkin's lymphoma (NHL).
  • In the present study we have searched for viral genomes and antigens in the malignant lymphoma tissues as well as their seroprevalence.
  • Antibodies against Hepatitis C as well as HCV RNA and hepatitis B surface antigen (HBsAg) were determined for 29 newly diagnosed non-Hodgkin's lymphoma patients using an enzyme linked immunosorbent assay (ELISA), as well as RT-PCR and compared with 36 apparently healthy individuals as a control group for viral markers.
  • Ten non-metastatic lymph nodes (LN) from cancer cases other than NHL were used as a control for IHC and molecular studies.
  • HCV was significantly more encountered in patients with NHL when compared to controls for both antibodies (27.6% versus 8.3% of serum controls; p = 0.04), and antigens studied by IHC in the involved LN (41% versus 10% of tissue controls; p = 0.06).
  • Although HBsAg positivity was not different in NHL patients when compared to controls (6.9% and 2.7%); yet it was significantly more encountered in LN of NHL patients (p = 0.04).
  • In conclusion, overall our findings confirm the presence of HBV and HCV antigens and viral sequences in the involved LNs of NHL patients, except for HCV RNA which perhaps necessitates fresh and not paraffin embedded tissues.
  • These results strengthen the assumption that these viruses may be involved in the development of NHL.

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  • (PMID = 17974155.001).
  • [ISSN] 1110-4902
  • [Journal-full-title] The Egyptian journal of immunology
  • [ISO-abbreviation] Egypt J Immunol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / Hepatitis B Surface Antigens; 0 / Hepatitis C Antibodies; 0 / NS3 protein, hepatitis C virus; 0 / Viral Nonstructural Proteins
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7. Olu-Eddo AN, Ohanaka CE: Peripheral lymphadenopathy in Nigerian adults. J Pak Med Assoc; 2006 Sep;56(9):405-8
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  • Tuberculosis lymphadenitis and metastatic disease were the major causes of lymph node enlargement constituting 114 (26.7%) and 113 (26.5%) cases respectively.
  • While tuberculosis was commonest in young adult females (15-24 years old) and rare above the age of 45 years, metastatic disease was the predominant cause of lymph node enlargement above 45 years.
  • Non Hodgkin's lymphoma and Hodgkin's lymphoma (HL) constituted 69 (16.2%) and 43 (10.1%) cases respectively.
  • HL occurred mostly in young adult males presenting with cervical lymphadenopathy (peak-age = 15-24 years).
  • Non specific lymphadenitis and onchocerciasis comprised 81 (19.0%) and 4 (0.9%) cases respectively.
  • [MeSH-minor] Adolescent. Adult. Developing Countries. Female. Humans. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies

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  • (PMID = 17091753.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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8. Pasqualotto AC, Rosa DD, Medeiros LR, Severo LC: Candidaemia and cancer: patients are not all the same. BMC Infect Dis; 2006;6:50
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  • Most of solid cancers were non-metastatic (71.9%).
  • Major diagnoses in patients with haematological neoplasia were acute leukaemia (n = 13), high grade non-Hodgkin lymphoma (n = 5) and Hodgkin's disease (n = 1).
  • Non-Candida albicans species caused 57.8% of the episodes of candidaemia in patients with cancer, mainly in patients with haematological malignancies (p = 0.034).
  • We then compared 2 groups of adult patients with candidaemia.
  • The first was composed of non-neutropenic patients with solid tumours, and the second group included patients without cancer.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antifungal Agents / therapeutic use. Child. Child, Preschool. Cohort Studies. Female. Humans. Infant. Male. Middle Aged. Odds Ratio. Retrospective Studies. Risk Factors

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  • (PMID = 16542444.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents
  • [Other-IDs] NLM/ PMC1431538
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9. Smymiotis V, Theodosopoulos T, Marinis A, Goula K, Psychogios J, Kondi-Pafiti A: Metastatic disease in the breast from nonmammary neoplasms. Eur J Gynaecol Oncol; 2005;26(5):547-50
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  • [Title] Metastatic disease in the breast from nonmammary neoplasms.
  • The metastatic involvement of the breast from nonmammary neoplasms is a relatively rare condition.
  • The primary malignancies were equally distributed between non-hematological (1 renal adenocarcinoma, 1 melanoma, 1 leiomyosarcoma) and hematological (1 non-Hodgkin's, 2 Hodgkin's lymphomas and 1 leukemia).
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adolescent. Adult. Aged. Breast Neoplasms, Male / diagnosis. Breast Neoplasms, Male / secondary. Diagnosis, Differential. Female. Hodgkin Disease / diagnosis. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / secondary. Leiomyosarcoma / diagnosis. Leiomyosarcoma / secondary. Leukemia / diagnosis. Lymphoma, Non-Hodgkin / diagnosis. Male. Melanoma / diagnosis. Melanoma / secondary. Neoplasm Metastasis. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Uterine Neoplasms / diagnosis. Uterine Neoplasms / secondary

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  • (PMID = 16285577.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 24
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10. Wood B, Sterrett G, Frost F, Swarbrick N: Diagnosis of extramammary malignancy metastatic to the breast by fine needle biopsy. Pathology; 2008 Jun;40(4):345-51
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  • [Title] Diagnosis of extramammary malignancy metastatic to the breast by fine needle biopsy.
  • The clinical data, with particular attention to the history of a known primary malignancy, previous systemic metastatic disease in other sites and presentation with extramammary disease in addition to a breast mass were examined.
  • The morphological appearances were reviewed and are illustrated, focusing on those features which allow the pathologist to recognise the possibility of metastatic disease and undertake appropriate steps to investigate this.
  • RESULTS: The 32 cases included metastases from a wide range of sites, including cutaneous melanoma (10), lung (8), non-Hodgkin's lymphoma (5), soft tissue (4), colon (2), endometrium, ovary and bladder.
  • The cytological features allow metastatic disease to be suspected in half of the cases, although in the others, particularly patients with metastatic adenocarcinoma, diagnosis without recourse to immunohistochemistry is difficult or impossible.
  • A combination of complete clinical history, attention to the cytological features and suspicion in cases with metastatic disease beyond the axilla should allow most cases of MMB to be suspected, and suitable material for ancillary confirmatory testing to be obtained.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / secondary. Lung Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology. Melanoma / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Female. Humans. Male. Middle Aged


11. Lien WC, Huang SP, Liu KL, Chang JH, Lai TI, Liu YP, Wang HP: The sandwich sign of non-lymphomatous origin. J Clin Ultrasound; 2009 May;37(4):212-4
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  • [Title] The sandwich sign of non-lymphomatous origin.
  • PURPOSE: To investigate the etiologies of the sandwich sign other than lymphoma.
  • The etiology was based on the pathologic report of mesenteric lymph nodes, or the presence of extensive metastatic disease in case of known advanced primary cancer or disappearance of the sign after specific treatments.
  • RESULTS: Malignancy accounted for the majority of cases (91%), and was divided into non-Hodgkin's lymphoma (50%) and metastatic carcinomas (41%).
  • The sandwich sign was 1 of the initial presentations in 11 cases with newly diagnosed malignancies, including 6 cases of non-Hodgkin's lymphoma and 5 cases of metastatic carcinomas.
  • CONCLUSION: Metastatic carcinomas, M. avium-complex, and M. tuberculosis infection may produce the sandwich sign.
  • Searching for etiologies other than lymphoma is important in patients presenting with the sandwich sign.
  • [MeSH-major] Lymph Nodes / ultrasonography. Lymphoma / ultrasonography. Mesentery / ultrasonography. Neoplasms / ultrasonography. Tuberculosis / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Lymphatic Metastasis / pathology. Lymphatic Metastasis / ultrasonography. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / ultrasonography. Male. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / ultrasonography. Retrospective Studies. Sensitivity and Specificity. Ultrasonography, Doppler / methods

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  • (PMID = 19065640.001).
  • [ISSN] 1097-0096
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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12. Ali TZ, Zakowski MF, Yung RC, Burroughs FH, Ali SZ: Exfoliative sputum cytology of cancers metastatic to the lung. Diagn Cytopathol; 2005 Sep;33(3):147-51
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  • [Title] Exfoliative sputum cytology of cancers metastatic to the lung.
  • Thirty-five cases of secondary/metastatic tumors involving the lung and diagnosed on sputum were retrospectively reviewed from our cytopathology files for a period of 22 yr (1980-2001).
  • Cytological diagnoses included colonic adenocarcinoma (7 cases); non-Hodgkin's lymphoma (NHL; 5 cases); malignant melanoma (MM; 5 cases); breast carcinoma (5 cases); Hodgkin's lymphoma (HL; 3 cases); pancreatic adenocarcinoma (2 cases); prostatic adenocarcinoma (2 cases); and 1 case each of urothelial carcinoma, endometrial carcinoma, renal cell carcinoma, hepatic small-cell carcinoma, squamous-cell carcinoma (cervix), and leiomyosarcoma (LMS).
  • In non-lymphoid tumors (27 cases), isolated single malignant cells were seen in 7 (26%) cases (all cases of MM and prostatic adenocarcinoma), whereas 20 (74%) cases displayed fragments with intact tumor architecture.
  • Exfoliation of cancer cells in sputum from secondary tumors in the lung is a rare phenomenon in current-day practice, with metastatic colonic adenocarcinoma seen most commonly.
  • [MeSH-minor] Adult. Aged. Cytodiagnosis / methods. Female. Humans. Male. Middle Aged

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078247.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Das P, Iyer VK, Mathur SR, Ray R: Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases. Cytopathology; 2010 Aug;21(4):251-8
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  • [Title] Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases.
  • OBJECTIVE: Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin's lymphoma that is difficult to diagnose on fine needle aspiration cytology (FNAC).
  • CONCLUSIONS: The morphological spectrum of ALCL is wide and it may be misdiagnosed as a metastatic poorly differentiated malignant tumour on FNAC.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / pathology
  • [MeSH-minor] Activin Receptors, Type II / metabolism. Adolescent. Adult. Biopsy, Fine-Needle. Female. Humans. Immunohistochemistry. Male. Middle Aged. Young Adult

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  • (PMID = 19744187.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.11.30 / ACVRL1 protein, human; EC 2.7.11.30 / Activin Receptors, Type II
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14. Kneile JR, Tan G, Suster S, Wakely PE Jr: Expression of CD30 (Ber-H2) in nasopharyngeal carcinoma, undifferentiated type and lymphoepithelioma-like carcinoma. A comparison study with anaplastic large cell lymphoma. Histopathology; 2006 Jun;48(7):855-61
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  • [Title] Expression of CD30 (Ber-H2) in nasopharyngeal carcinoma, undifferentiated type and lymphoepithelioma-like carcinoma. A comparison study with anaplastic large cell lymphoma.
  • AIMS: Undifferentiated nasopharyngeal non-keratinizing carcinoma (UNPC), formerly known as lymphoepithelioma, frequently metastasizes at an early stage to regional lymph nodes and, thus, may be difficult to distinguish from Hodgkin's lymphoma (HL) or anaplastic large cell lymphoma (ALCL).
  • METHODS AND RESULTS: CD30 immunoreactivity was examined in 38 cases of primary or metastatic UNPC, six cases of LELC, 10 cases of SCC and seven cases of ALCL.
  • [MeSH-major] Antigens, CD30 / biosynthesis. Carcinoma / pathology. Carcinoma, Squamous Cell / pathology. Lymphoma, Large-Cell, Anaplastic / pathology. Nasopharyngeal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged


15. Mondin V, Ferlito A, Devaney KO, Woolgar JA, Rinaldo A: A survey of metastatic central nervous system tumors to cervical lymph nodes. Eur Arch Otorhinolaryngol; 2010 Nov;267(11):1657-66
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  • [Title] A survey of metastatic central nervous system tumors to cervical lymph nodes.
  • Less often, both adults and children may present with cervical masses caused by either non-Hodgkin's lymphoma or Hodgkin's disease.
  • The present review examines the published experience with 128 tumors that gave rise to cervical node metastases in both adult and in pediatric patients.
  • Cervical node metastases may arise from glial tumors (including glioblastoma multiforme, in both adult and pediatric patients) and non-glial tumors (such as medulloblastoma in pediatric patients).

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  • (PMID = 20694730.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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16. Arotiba JT, Akadiri OA, Okeke LI, Obimakinde OS, Fasola AO, Okoje VN, Kolude B: Multiple malignant lesions involving the orofacial region: a case report. Afr J Med Med Sci; 2006 Sep;35(3):375-9
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  • While the co-existence of paraplegia and mental nerve neuropathy is a possible feature of metastatic prostate cancer involving the spine and mandible, the concomitant occurrence of multiple facial swellings involving the anterior mandible with its related gingival and lip mucosa, frontal bone and parotid glands is a rare finding.
  • Fine needle aspiration cytology (FNAC) of the parotid lesion and incisional biopsy of the gingival lesion were reported as Lymphoblastic lymphoma and Non Hodgkin's Lymphoma respectively.
  • [MeSH-major] Adenocarcinoma / pathology. Lymphoma, Non-Hodgkin / pathology. Neoplasms, Multiple Primary / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Gingiva / pathology. Humans. Male. Parotid Gland / pathology

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  • (PMID = 17312748.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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17. Krishna NB, Gardner L, Collins BT, Agarwal B: Periportal lymphadenopathy in patients without identifiable pancreatobiliary or hepatic malignancy. Clin Gastroenterol Hepatol; 2006 Nov;4(11):1373-7
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  • Malignant infiltration and enlargement of periportal nodes occur in patients with cancers of the liver, gallbladder, biliary tree, and pancreas and lymphoma.
  • Twelve of the 64 patients (18.8%; 95% confidence interval, 9.2%-28.4%) had a malignant cause of enlarged periportal lymph nodes: 5 with metastatic carcinoma and 7 with non-Hodgkin's lymphoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Comorbidity. Endosonography. Female. Humans. Lymphatic Metastasis. Lymphoma, Non-Hodgkin / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17059897.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Postema EJ, McEwan AJ, Riauka TA, Kumar P, Richmond DA, Abrams DN, Wiebe LI: Initial results of hypoxia imaging using 1-alpha-D: -(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole ( 18F-FAZA). Eur J Nucl Med Mol Imaging; 2009 Oct;36(10):1565-73
The Lens. Cited by Patents in .

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  • The safety and general biodistribution patterns of this radiopharmaceutical in patients with squamous cell carcinoma of the head and neck (HNSCC), small-cell lung cancer (SCLC) or non-small-cell lung cancer (NSCLC), malignant lymphoma, and high-grade gliomas, were demonstrated in this study.
  • METHODS: Patients with known primary or suspected metastatic HNSCC, SCLC or NSCLC, malignant lymphoma or high-grade gliomas were dosed with 5.2 MBq/kg of (18)F-FAZA, then scanned 2-3 h after injection using a PET or PET/CT scanner.
  • Of the 21 lymphoma patients (15 with non-Hodgkin's lymphoma and 6 with Hodgkin's disease), 3 demonstrated moderate lymphoma-related uptake.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Carcinoma, Small Cell / radionuclide imaging. Carcinoma, Squamous Cell / radionuclide imaging. Female. Fluorine Radioisotopes. Glioma / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Humans. Lung Neoplasms / radionuclide imaging. Lymphoma / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography. Young Adult

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  • (PMID = 19430784.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Nitroimidazoles; 0 / Radiopharmaceuticals; 0 / fluoroazomycin arabinoside
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19. Khademi B, Taraghi A, Mohammadianpanah M: Anatomical and histopathological profile of head and neck neoplasms in Persian pediatric and adolescent population. Int J Pediatr Otorhinolaryngol; 2009 Sep;73(9):1249-53
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  • Orbital and skin tumors and neoplasms with secondary (metastatic) involvement of the head and neck were excluded from the study.
  • Lymphomas [Non-Hodgkin's lymphomas (30%), Hodgkin's disease (25%)], carcinomas (20%), and sarcomas (10.5%) were the most frequent histopathological types.
  • [MeSH-major] Carcinoma / epidemiology. Head and Neck Neoplasms / epidemiology. Lymphoma / epidemiology. Sarcoma / epidemiology
  • [MeSH-minor] Adolescent. Age Factors. Child. Child, Preschool. Female. Hospitals, Teaching / statistics & numerical data. Humans. Incidence. Infant. Iran / epidemiology. Male. Registries. Young Adult

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  • (PMID = 19525017.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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20. Zurada JM, Ward KM, Grossman ME: Henoch-Schönlein purpura associated with malignancy in adults. J Am Acad Dermatol; 2006 Nov;55(5 Suppl):S65-70
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  • A total of 31 cases have been reported in the world literature of adult malignancy-associated HSP.
  • The most frequent tumors were lung (nonsmall-cell) (n = 8), multiple myeloma (n = 5), prostate (n = 5), and non-Hodgkin's lymphoma (n = 3).
  • We also advise that patients with a known history of malignancy who present with HSP be evaluated for metastatic disease.

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  • (PMID = 17052537.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Wu JM, Sheth S, Ali SZ: Cytopathologic analysis of paraspinal masses: a study of 59 cases with clinicoradiologic correlation. Diagn Cytopathol; 2005 Sep;33(3):157-61
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  • Of the malignant cases, 22 (76%) were metastatic tumors from various sites, while 7 (24%) were cancers from local spread, which included non-Hodgkin's lymphoma (NHL, 5) and myeloma (2).
  • Metastatic tumors consisted of adenocarcinoma, 9; squamous-cell carcinoma, 3; renal-cell carcinoma, 1; and non-small-cell carcinoma/not otherwise specified (NOS), 9.
  • The most common lesion encountered is metastatic adenocarcinoma, followed by NHL.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Sensitivity and Specificity

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078252.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Wang Z, Tong ZH, Li HJ, Zhao TT, Li XY, Xu LL, Luo J, Jin ML, Li RS, Wang C: Semi-rigid thoracoscopy for undiagnosed exudative pleural effusions: a comparative study. Chin Med J (Engl); 2008 Aug 5;121(15):1384-9

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  • RESULTS: Medical thoracoscopy revealed tuberculous pleurisy in 6 patients, adenocarcinoma in 7, squamous-cell carcinoma in 2, metastatic carcinoma in 3, mesothelioma in 2, non-Hodgkin's lymphoma in 1, and others in 4.
  • Only 21% patients were diagnosed after routine examinations, including parapneumonic effusion in 2 patients, lung cancer in 2 and undetermined metastatic malignancy in 1.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18959114.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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23. Pires NF, Morais A, Queiroga H: Superior vena cava syndrome as tumour presentation. Rev Port Pneumol; 2010 Jan-Feb;16(1):73-88
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  • It is noticeable that 10% were diagnosed with non- Hodgkin's lymphoma.
  • In terms of prognostic factors analysed, the absence of metastasis, the lymphoma's histological diagnosis, good performance status and non-smoker status were positively correlated with the survival rate.
  • CONCLUSIONS: In our analysis we concluded that SCLC, smokers and a poorer performance status as well as metastatic disease were unfavourable prognostic factors to SVCS as tumour presentation.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 20054509.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Portugal
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24. Dragovich T, Gordon M, Mendelson D, Wong L, Modiano M, Chow HH, Samulitis B, O'Day S, Grenier K, Hersh E, Dorr R: Phase I trial of imexon in patients with advanced malignancy. J Clin Oncol; 2007 May 1;25(13):1779-84
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  • PATIENTS AND METHODS: Forty-nine patients with metastatic cancer received intravenous imexon over 30 to 45 minutes for 5 consecutive days (one course) every other week (days 1 through 5 and 15 through 19) monthly.
  • One partial response was obtained in a heavily pretreated patient with non-Hodgkin's lymphoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Area Under Curve. Female. Half-Life. Humans. Infusions, Intravenous. Male. Maximum Tolerated Dose. Middle Aged

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  • (PMID = 17470869.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-17094
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Hexanones; 59643-91-3 / 4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one
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25. Bailey AA, Debinski HS, Appleyard MN, Remedios ML, Hooper JE, Walsh AJ, Selby WS: Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience. Am J Gastroenterol; 2006 Oct;101(10):2237-43

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  • Two lesions were non-neoplastic: heterotopic gastric mucosa and inflammatory fibroid polyp.
  • Seventeen tumors were malignant: five adenocarcinomas, six carcinoids, two melanoma metastases, two gastrointestinal stromal tumors (GIST), one colon carcinoma metastasis, one non-Hodgkin's lymphoma.
  • Even in malignant lesions, treatment is potentially curative in the absence of metastatic disease.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Australia. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17032187.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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26. Holzapfel K, Duetsch S, Fauser C, Eiber M, Rummeny EJ, Gaa J: Value of diffusion-weighted MR imaging in the differentiation between benign and malignant cervical lymph nodes. Eur J Radiol; 2009 Dec;72(3):381-7
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  • RESULTS: Cervical lymph node enlargement was secondary to metastases from squamous cell carcinomas [n=25], non-Hodgkin's lymphoma [n=6], reactive lymphadenitis [n=20], cat scratch lymphadenitis [n=2] and sarcoidosis [n= 2].
  • The mean ADC values (x10(-3) mm(2)/s) were 0.78+/-0.09 for metastatic lymph nodes, 0.64+/-0.09 for lymphomatous nodes and 1.24+/-0.16 for benign cervical lymph nodes.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neck / pathology. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 18995981.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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