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1. Fleming FJ, Vytopil M, Chaitow J, Jones HR Jr, Darras BT, Ryan MM: Thalidomide neuropathy in childhood. Neuromuscul Disord; 2005 Feb;15(2):172-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • More recently, however, thalidomide treatment has been reintroduced to adult and paediatric practice for a variety of dermatologic, immunologic, rheumatologic and neoplastic disorders.
  • We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.
  • [MeSH-major] Gait Disorders, Neurologic / chemically induced. Peripheral Nerves / drug effects. Peripheral Nervous System Diseases / chemically induced. Thalidomide / adverse effects
  • [MeSH-minor] Action Potentials / drug effects. Action Potentials / physiology. Adolescent. Brain Neoplasms / drug therapy. Child. Crohn Disease / drug therapy. Disease Progression. Electromyography. Ependymoma / drug therapy. Humans. Male. Muscle Weakness / chemically induced. Muscle Weakness / pathology. Muscle Weakness / physiopathology. Muscle, Skeletal / innervation. Muscle, Skeletal / pathology. Muscle, Skeletal / physiopathology. Neural Conduction / drug effects. Neural Conduction / physiology. Neurologic Examination / standards. Neurotoxins / adverse effects. Ulcer / drug therapy. Withholding Treatment

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  • Hazardous Substances Data Bank. THALIDOMIDE .
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  • (PMID = 15694139.001).
  • [ISSN] 0960-8966
  • [Journal-full-title] Neuromuscular disorders : NMD
  • [ISO-abbreviation] Neuromuscul. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neurotoxins; 4Z8R6ORS6L / Thalidomide
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2. Reuther FJ, Löhler J, Herms J, Hugo HH, Schindler C, Leithäuser F, Melzner I, Möller P, Scheil S: Low incidence of SV40-like sequences in ependymal tumours. J Pathol; 2001 Dec;195(5):580-5
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  • Between 1955 and 1963, millions of children and adults were exposed to SV40-contaminated poliovirus vaccines.
  • Only three (5%) of the tumours--including 24 classical, 20 anaplastic, and 12 myxopapillary ependymomas; one subependymoma; and five ependymoblastomas--revealed subgenomic SV40 sequences.
  • The positive tumours represent 7% of grade II and III ependymomas (two paediatric and one adult tumour).
  • DNA sequencing of the PCR product revealed identical sequences of SV40 in the positive ependymal tumours.
  • These differences may reflect different degrees of exposure to SV40-contaminated polio vaccine.
  • [MeSH-major] Ependymoma / virology. Simian virus 40 / isolation & purification
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. DNA, Viral / analysis. Drug Contamination. Germany / epidemiology. Humans. Incidence. Infant. Male. Middle Aged. Poliovirus Vaccines. Polymerase Chain Reaction / methods

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  • [Copyright] Copyright 2001 John Wiley & Sons, Ltd.
  • (PMID = 11745694.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Poliovirus Vaccines
  • [Number-of-references] 27
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3. Gilbert MR, Ruda R, Soffietti R: Ependymomas in adults. Curr Neurol Neurosci Rep; 2010 May;10(3):240-7
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  • They occur most commonly in the spinal cord, where histopathologic evaluation is critical to differentiate the grade I myxopapillary ependymoma from the grade II ependymoma or grade III anaplastic ependymoma.
  • For myxopapillary ependymoma, complete removal while maintaining capsule integrity may be curative.
  • Ongoing laboratory studies have uncovered important signal transduction pathways that may be better therapeutic targets, leading to the development of clinical trials using targeted agents.
  • [MeSH-major] Central Nervous System Neoplasms. Ependymoma
  • [MeSH-minor] Adult. Epigenesis, Genetic. Humans

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  • (PMID = 20425040.001).
  • [ISSN] 1534-6293
  • [Journal-full-title] Current neurology and neuroscience reports
  • [ISO-abbreviation] Curr Neurol Neurosci Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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