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Items 1 to 44 of about 44
1. Jakowski JD, Wakely PE Jr: Cytopathology of extraskeletal myxoid chondrosarcoma: report of 8 cases. Cancer; 2007 Oct 25;111(5):298-305
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  • [Title] Cytopathology of extraskeletal myxoid chondrosarcoma: report of 8 cases.
  • BACKGROUND: Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft-tissue sarcoma rarely subjected to cytologic analysis.
  • METHODS: The cytology files were reviewed for all soft-tissue lesions signed out as chondrosarcoma, myxoid sarcoma, and EMC, and the tissue files for any cases of EMC that had corresponding cytopathology.
  • Five cases were correctly and categorically diagnosed by the cytologic method as EMC, 1 as chondrosarcoma favor EMC, 1 as sarcoma favor EMC, and 1 as myxoid spindle/epithelial neoplasm.
  • Cytologic features ranged from hypocellular to highly cellular smears composed primarily of rounded cells set in an abundant myxoid stroma that varied from opaque to semitransparent and lacked vascularity or necrosis.
  • CONCLUSIONS: A confident cytologic diagnosis of EMC depends on the presence of a uniform, round to oval cell population often arranged in cords and set in an abundant myxoid/chondromyxoid background and arising in the appropriate clinical context.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cytodiagnosis. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 17676582.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Wang WL, Mayordomo E, Czerniak BA, Abruzzo LV, Dal Cin P, Araujo DM, Lev DC, López-Terrada D, Lazar AJ: Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma. Mod Pathol; 2008 Nov;21(11):1303-10
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  • [Title] Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma.
  • Extraskeletal myxoid chondrosarcoma is a rare soft tissue tumor characterized by a nodular growth pattern with eosinophilic cells usually in a reticular pattern and abundant myxoid stroma.
  • In contrast to other myxoid sarcomas, the majority of extraskeletal myxoid chondrosarcomas harbor a balanced translocation, t(9;22)(q22;q12), that fuses EWSR1 with NR4A3 (also known as CHN).
  • We examined the diagnostic utility of fluorescence in situ hybridization for extraskeletal myxoid chondrosarcoma using the LSI EWSR1 break-apart probe (Abbott Molecular/Vysis, Des Plaines, IL, USA).
  • Sixteen cases of extraskeletal myxoid chondrosarcoma with formalin-fixed paraffin-embedded tissue available were retrieved (1991-2007).
  • In this study, the vast majority of extraskeletal myxoid chondrosarcomas are associated with a rearrangement at the EWSR1 locus (22q12).
  • Fluorescence in situ hybridization is useful to support the diagnosis of extraskeletal myxoid chondrosarcomas and may help to differentiate it from mimics such as other myxoid sarcomas, particularly in limited biopsies.
  • [MeSH-major] Calmodulin-Binding Proteins / genetics. Chondrosarcoma / diagnosis. RNA-Binding Proteins / genetics. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Chromosomes, Human, Pair 22. Chromosomes, Human, Pair 9. DNA, Neoplasm / genetics. Diagnosis, Differential. Extremities. Female. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Sarcoma / diagnosis. Translocation, Genetic

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  • (PMID = 18587326.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / DNA, Neoplasm; 0 / EWSR1 protein, human; 0 / RNA-Binding Proteins
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3. Heyse TJ, Malcherczyk D, Moll R, Timmesfeld N, Wapelhorst J, Fuchs-Winkelmann S, Paletta JR, Schofer MD: CD44: survival and metastasis in chondrosarcoma. Osteoarthritis Cartilage; 2010 Jun;18(6):849-56
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  • [Title] CD44: survival and metastasis in chondrosarcoma.
  • OBJECTIVE: Recent studies have shown abnormal expression of CD44s and some of its isoforms in many human malignancies, but little is known about the presence of CD44 in chondrosarcoma.
  • METHOD: Thirty paraffin-embedded chondrosarcoma samples were immunostained with monoclonal antibodies for CD44s, CD44v5 and CD44v6.
  • RESULTS: Among the 30 patients (median age 50 years) there were 22 conventional chondrosarcomas, two dedifferentiated chondrosarcomas, two extraskeletal chondrosarcomas, and one periostal, mesenchymal, clear cell and myxoid chondrosarcoma each.
  • CONCLUSIONS: Overexpression of CD44s correlated significantly with metastatic potential and with poorer survival in patients with chondrosarcoma.

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  • [Copyright] Copyright 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20171296.001).
  • [ISSN] 1522-9653
  • [Journal-full-title] Osteoarthritis and cartilage
  • [ISO-abbreviation] Osteoarthr. Cartil.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Protein Isoforms
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4. Drilon AD, Popat S, Bhuchar G, D'Adamo DR, Keohan ML, Fisher C, Antonescu CR, Singer S, Brennan MF, Judson I, Maki RG: Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy. Cancer; 2008 Dec 15;113(12):3364-71
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  • [Title] Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy.
  • BACKGROUND: Extraskeletal myxoid chondrosarcoma (EMC) is a genetically distinct sarcoma with a propensity for local recurrence and metastasis despite an indolent course.
  • [MeSH-major] Chondrosarcoma / drug therapy. Chondrosarcoma / surgery. Soft Tissue Neoplasms / drug therapy. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 18951519.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA047179-15A2; United States / NCI NIH HHS / CA / P01 CA047179-18; United States / NCI NIH HHS / CA / P01-CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS139129; NLM/ PMC2779719
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5. Donati D, Colangeli S, Colangeli M, Di Bella C, Bertoni F: Surgical treatment of grade I central chondrosarcoma. Clin Orthop Relat Res; 2010 Feb;468(2):581-9
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  • [Title] Surgical treatment of grade I central chondrosarcoma.
  • The grade of chondrosarcoma relates to the likelihood of local recurrence and metastases.
  • The two recurrences occurred in patients whose radiographs showed thinning of the cortex combined with bone enlargement and marked endosteal scalloping; histologic examination in these two patients also showed a correlation between radiographic aggressiveness and the presence of myxoid areas and hypercellularity.
  • [MeSH-major] Bone Neoplasms / surgery. Chondrosarcoma / surgery. Femur / surgery. Humerus / surgery. Orthopedic Procedures. Tibia / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Arthroplasty, Replacement. Bone Transplantation. Curettage. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Osteotomy. Reoperation. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 19727994.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2806970
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6. Mavrogenis AF, Patapis P, Papaparaskeva KT, Galanis EC, Papagelopoulos PJ: Extraskeletal myxoid chondrosarcoma of the perineum. Orthopedics; 2009 Mar;32(3):216
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  • [Title] Extraskeletal myxoid chondrosarcoma of the perineum.
  • Extraskeletal myxoid chondrosarcoma is an aggressive tumor with significant metastatic potential.
  • A computed tomography-guided core needle biopsy was consistent with low-grade extraskeletal myxoid chondrosarcoma.
  • Histological analysis of the excised specimens was consistent with extraskeletal myxoid chondrosarcoma metastases.
  • Extraskeletal myxoid chondrosarcoma is an unusual soft tissue sarcoma with ultrastructural and molecular features distinct from that of skeletal myxoid chondrosarcoma.
  • The EWS-CHN gene fusion is highly specific to extraskeletal myxoid chondrosarcoma; the gene fusion is positive in >or=75% of cases.
  • Because of the prolonged survival of patients with extraskeletal myxoid chondrosarcoma, long-term follow-up is recommended for early detection of local recurrence or distant metastases.
  • [MeSH-major] Chondrosarcoma / secondary. Perineum / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Disease-Free Survival. Humans. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Lymph Nodes / pathology. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Radiography, Thoracic. Thoracotomy. Treatment Outcome

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  • (PMID = 19309044.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Sorimachi T, Sasaki O, Nakazato S, Koike T, Shibuya H: Myxoid chondrosarcoma in the pineal region. J Neurosurg; 2008 Nov;109(5):904-7
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  • [Title] Myxoid chondrosarcoma in the pineal region.
  • The authors report a case of a myxoid chondrosarcoma of the pineal region in a 37-year-old woman who presented with an intratumoral hemorrhage.
  • Histological and immunohistochemical findings after the second surgery were consistent with a diagnosis of myxoid chondrosarcoma.
  • Radical excision of a tumor was considered to play an important role in the management of intracranial myxoid chondrosarcoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Pineal Gland
  • [MeSH-minor] Adult. Female. Hemorrhage / etiology. Humans. Magnetic Resonance Imaging

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  • (PMID = 18976082.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Ehara S, Nishida J, Shiraishi H, Yoshioka H, Okada K, Sumiya H, Takano H: Skeletal recurrences and metastases of extraskeletal myxoid chondrosarcoma. Skeletal Radiol; 2007 Sep;36(9):823-7
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  • [Title] Skeletal recurrences and metastases of extraskeletal myxoid chondrosarcoma.
  • OBJECTIVE: The objective was to elucidate clinical and imaging features of skeletal involvement, recurrences, and metastases of extraskeletal myxoid chondrosarcoma.
  • CONCLUSION: Although skeletal metastases of chondrosarcoma of bone and soft tissue are rare, myxoid chondrosarcomas, currently classified tumors of uncertain differentiation, rarely metastasize and/or recur in the bones.
  • [MeSH-major] Bone Neoplasms / secondary. Chondrosarcoma / pathology. Chondrosarcoma / secondary. Lung Neoplasms / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Multicenter Studies as Topic. Neoplasm Metastasis. Recurrence. Retrospective Studies

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  • (PMID = 17437101.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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9. Tateishi U, Hasegawa T, Nojima T, Takegami T, Arai Y: MRI features of extraskeletal myxoid chondrosarcoma. Skeletal Radiol; 2006 Jan;35(1):27-33
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  • [Title] MRI features of extraskeletal myxoid chondrosarcoma.
  • OBJECTIVE: To describe the MRI features of extraskeletal myxoid chondrosarcoma in comparison with clinicopathologic findings.
  • CONCLUSION: Extraskeletal myxoid chondrosarcoma is an uncommon soft-tissue malignancy that may be recognized by MRI features of multi-lobular soft-tissue mass often invading extracompartmental, bony, and vascular structures.
  • [MeSH-major] Chondrosarcoma / pathology. Magnetic Resonance Imaging / methods. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Neoplasms / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 16220270.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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10. Gupta R, Sharma MC, Attri S, Guleria S: Testicular metastasis of extraskeletal myxoid chondrosarcoma: report of first case. Urology; 2008 May;71(5):984.e1-4
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  • [Title] Testicular metastasis of extraskeletal myxoid chondrosarcoma: report of first case.
  • Metastasis from extraskeletal myxoid chondrosarcoma to the testis has not been previously reported.
  • We report a case of extraskeletal myxoid chondrosarcoma that, 4 years after surgery, manifested with testicular enlargement, a period punctuated by three local recurrences.
  • The testicular tumor showed pathologic features similar to the previous specimens, and metastatic myxoid chondrosarcoma was diagnosed.
  • To the best of our knowledge, this is the first case of extraskeletal myxoid chondrosarcoma with metastasis to the testis.
  • [MeSH-major] Chondrosarcoma / secondary. Soft Tissue Neoplasms / pathology. Testicular Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 18308379.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. O'Brien J, Thornton J, Cawley D, Farrell M, Keohane K, Kaar G, McEvoy L, O'Brien DF: Extraskeletal myxoid chondrosarcoma of the cerebellopontine angle presenting during pregnancy. Br J Neurosurg; 2008 Jun;22(3):429-32
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  • [Title] Extraskeletal myxoid chondrosarcoma of the cerebellopontine angle presenting during pregnancy.
  • Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft-tissue sarcoma, which usually occurs in the lower extremities.
  • The clinical, radiological and pathological findings in extraskeletal myxoid chondrosarcoma, with an origin in the cerebellopontine angle, are described along with the issues associated with management of this tumour presenting acutely in a 26-year-old woman who was 20 weeks pregnant.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Chondrosarcoma / pathology. Pregnancy Complications, Neoplastic / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Treatment Outcome

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  • (PMID = 18568733.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Ceylan K, Kizilkaya Z, Yavanoglu A: Extraskeletal myxoid chondrosarcoma of the nasal cavity. Eur Arch Otorhinolaryngol; 2006 Nov;263(11):1044-7
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  • [Title] Extraskeletal myxoid chondrosarcoma of the nasal cavity.
  • Extraskeletal myxoid chondrosarcoma presenting in the head and neck is extremely rare.
  • The tumour has a better prognosis than myxoid chondrosarcoma of the bone but surgical resection may be difficult due to its gelatinous nature.
  • We present a case of extraskeletal myxoid chondrosarcoma originating in the left nasal cavity of a 35-year-old woman.
  • [MeSH-major] Chondrosarcoma / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 16816935.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Subramanian S, West RB, Marinelli RJ, Nielsen TO, Rubin BP, Goldblum JR, Patel RM, Zhu S, Montgomery K, Ng TL, Corless CL, Heinrich MC, van de Rijn M: The gene expression profile of extraskeletal myxoid chondrosarcoma. J Pathol; 2005 Aug;206(4):433-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The gene expression profile of extraskeletal myxoid chondrosarcoma.
  • Extraskeletal myxoid chondrosarcoma (EMC) is a soft tissue tumour that occurs primarily in the extremities and is characterized by a balanced translocation most commonly involving t(9;22) (q22;q12).
  • [MeSH-major] Chondrosarcoma / genetics. Gene Expression Regulation, Neoplastic / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Cell Differentiation / genetics. Cell Division / genetics. Cluster Analysis. DNA, Neoplasm / genetics. Female. Humans. In Situ Hybridization / methods. Male. Microtubules / genetics. Middle Aged. Neoplasm Proteins / analysis. Neurokinin B / analogs & derivatives. Neurokinin B / analysis. Oligonucleotide Array Sequence Analysis / methods. Oncogenes / genetics. Proto-Oncogene Proteins c-kit / genetics. Signal Transduction / genetics

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland
  • (PMID = 15920699.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA85129
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 86933-75-7 / Neurokinin B; 87096-84-2 / neuromedin B; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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14. Kwon JW, Choi JA, Kwack KS, Oh JH, Chung JH, Kang HS: Myxoid chondrosarcoma in the calcaneus: a case report with MR imaging findings. Skeletal Radiol; 2007 Jun;36 Suppl 1:S82-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid chondrosarcoma in the calcaneus: a case report with MR imaging findings.
  • Skeletal myxoid chondrosarcoma is an extraordinarily rare neoplasm with a distinct histological morphology.
  • Herein, we report a case of a myxoid chondrosarcoma in the calcaneus of a 20-year-old man with a description of its MR imaging (MRI) and histological findings.
  • [MeSH-major] Calcaneus / pathology. Chondrosarcoma / diagnosis. Magnetic Resonance Imaging. Myxosarcoma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Male

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  • (PMID = 17219232.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Kotil K, Bilge T, Olagac V: Primary intradural myxoid chondrosarcoma: a case report and review in the literature. J Neurooncol; 2005 Nov;75(2):169-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intradural myxoid chondrosarcoma: a case report and review in the literature.
  • We report the first case in the literature of a primary intradural myxoid chondrosarcoma.
  • We could not identify this lesion as chondrosarcoma in preoperative period.
  • The mass was excised completely and microscopic examination identified a myxomatous chondrosarcoma.
  • But a histological examination revealed primary myxoid chondrosarcoma.
  • This case presents the first case in the literature of an primary spinal intradural myxoid chondrosarcoma.
  • [MeSH-major] Chondrosarcoma, Mesenchymal / diagnosis. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Pia Mater / pathology
  • [MeSH-minor] Adult. Dura Mater / surgery. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Time Factors. Treatment Outcome. X-Rays

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  • (PMID = 16283441.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 12
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16. Mroczkowski P, Evert M, Tautenhahn J, Meyer F, Lippert H: [A rare extra-skeletal myxoid chondrosarcoma of the lower leg - is amputation absolutely necessary]. Zentralbl Chir; 2010 Feb;135(1):83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare extra-skeletal myxoid chondrosarcoma of the lower leg - is amputation absolutely necessary].
  • The aim of this case report is to show the management of an extraordinary extra-skeletal myxoid chondrosarcoma based on a case report with references from the literature.
  • Histopathological investigation of a percutaneous biopsy revealed a chondrosarcoma.
  • En-bloc-resection (R 0) of the rear superficial compartment was performed (specimen weight 1 370 g; tumour size 11.5 x 9.5 x 8 cm) leading to the definitive diagnosis of an extra-skeletal myxoid chondrosarcoma.
  • DISCUSSION: The myxoid chondrosarcoma is a rare tumour lesion, and according to the literature, only 2 % occur outside of the skeleton.
  • [MeSH-major] Amputation. Chondrosarcoma / surgery. Leg / surgery. Muscle Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy. Combined Modality Therapy. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Radiotherapy, Adjuvant

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  • [Copyright] Georg Thieme Verlag Stuttgart, New York.
  • (PMID = 19890812.001).
  • [ISSN] 1438-9592
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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17. Willems SM, Schrage YM, Baelde JJ, Briaire-de Bruijn I, Mohseny A, Sciot R, Bovée JV, Hogendoorn PC: Myxoid tumours of soft tissue: the so-called myxoid extracellular matrix is heterogeneous in composition. Histopathology; 2008 Mar;52(4):465-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid tumours of soft tissue: the so-called myxoid extracellular matrix is heterogeneous in composition.
  • AIM: Myxoid tumours of soft tissue are characterized by their so-called 'myxoid' extracellular matrix.
  • METHODS AND RESULTS: Using Alcian Blue staining with and without pretreatment with hyaluronidase and application of the critical electrolyte concentration method followed by densitometry, the glycosaminoglycan composition of three different myxoid tumours was studied.
  • The composition of glycosaminoglycans varied with tumour type and grade, despite their general characterization as myxoid tumours.
  • Intramuscular myxoma contained similar amounts of the various glycosaminoglycans as grade I myxofibrosarcoma; grade III myxofibrosarcoma contained less hyaluronic acid and more heparan sulphate, whereas extraskeletal myxoid chondrosarcoma contained predominantly chondroitin-4 and -6 sulphates.
  • CONCLUSIONS: The extracellular matrix of myxoid tumours of soft tissue has a heterogeneous composition consisting of, amongst others, glycosaminoglycans and albumin, which appear to play an active role in their morphogenesis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Albumins / chemistry. Albumins / genetics. Alcian Blue / chemistry. Blotting, Western. Coloring Agents / chemistry. Female. Glycosaminoglycans / chemistry. Glycosaminoglycans / classification. Humans. In Situ Hybridization. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / metabolism. Retrospective Studies. Tissue Array Analysis

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  • (PMID = 18315599.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Albumins; 0 / Coloring Agents; 0 / Glycosaminoglycans; 0 / RNA, Messenger; P4448TJR7J / Alcian Blue
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18. Mohammadinezhad C: Chondrosarcoma of the jaw. J Craniofac Surg; 2009 Nov;20(6):2097-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondrosarcoma of the jaw.
  • Chondrosarcoma of the maxillofacial region is a rare tumor.
  • The classification of this tumor is based on histologic grades (1, 2, or 3) or variant including clear cell, differentiated, myxoid, and mesenchymal chondrosarcomas.
  • The most acceptable choice of treatment of the chondrosarcoma is wide resection.
  • However, lifelong follow-up is essential because chondrosarcoma shows a high incidence of local recurrence as well as regional and distant metastasis more than 2 decades later.
  • This study presents 2 cases of chondrosarcoma with a long-term follow-up.
  • [MeSH-major] Chondrosarcoma / pathology. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Nose. Orbital Implants. Prostheses and Implants. Skull Base Neoplasms / secondary. Skull Base Neoplasms / surgery

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  • (PMID = 19881362.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Kumar R, Rekhi B, Shirazi N, Pais A, Amare P, Gawde D, Jambhekar N: Spectrum of cytomorphological features, including literature review, of an extraskeletal myxoid chondrosarcoma with t(9;22)(q22;q12) (TEC/EWS) results in one case. Diagn Cytopathol; 2008 Dec;36(12):868-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spectrum of cytomorphological features, including literature review, of an extraskeletal myxoid chondrosarcoma with t(9;22)(q22;q12) (TEC/EWS) results in one case.
  • Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon soft tissue sarcoma with evolving literature on its cytomorphological features and limited documentation of its molecular analysis.
  • [MeSH-major] Bone Neoplasms / pathology. Chondrosarcoma / pathology. Chromosomes, Human, Pair 22 / genetics. Chromosomes, Human, Pair 9 / genetics. RNA-Binding Protein EWS / genetics. Translocation, Genetic
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18925568.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA-Binding Protein EWS
  • [Number-of-references] 29
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20. Noguchi H, Mitsuhashi T, Seki K, Tochigi N, Tsuji M, Shimoda T, Hasegawa T: Fluorescence in situ hybridization analysis of extraskeletal myxoid chondrosarcomas using EWSR1 and NR4A3 probes. Hum Pathol; 2010 Mar;41(3):336-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fluorescence in situ hybridization analysis of extraskeletal myxoid chondrosarcomas using EWSR1 and NR4A3 probes.
  • Extraskeletal myxoid chondrosarcomas (EMCs) are characterized histologically by a cord-like or lace-like arrangement of small round cells or short spindle cells with eosinophilic cytoplasm distributed in a rich myxoid matrix.
  • [MeSH-major] Calmodulin-Binding Proteins / genetics. Chondrosarcoma / genetics. DNA-Binding Proteins / genetics. RNA-Binding Proteins / genetics. Receptors, Steroid / genetics. Receptors, Thyroid Hormone / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Proteins / genetics. Oncogene Fusion / genetics. Oncogene Proteins, Fusion / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19775727.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / DNA-Binding Proteins; 0 / EWSR1 protein, human; 0 / NR4A3 protein, human; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Proteins; 0 / Receptors, Steroid; 0 / Receptors, Thyroid Hormone
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21. Wong NL, DI F: [Fine needle aspiration cytology of myxoid lesions of soft tissues: a study of 24 cases]. Zhonghua Bing Li Xue Za Zhi; 2007 Sep;36(9):619-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Fine needle aspiration cytology of myxoid lesions of soft tissues: a study of 24 cases].
  • OBJECTIVE: To summarize the diagnostic features of fine needle aspiration cytology (FNAC) of myxoid lesions in soft tissue, and to define the cytological criteria for differentiating benign lesions from sarcomas and between various myxoid lesions.
  • METHODS: FNAC data of 24 soft tissue myxoid lesions (14 benign lesions, 10 malignant lesions) from 1993 to 2006 from Kiang Wu Hospital, Macau were reviewed in correlation with the clinical course or the results of biopsy.
  • RESULTS: Ganglion, myxoma, and myxoid nodular fasciitis were the most common benign myxoid lesions of the soft tissues, all of which had low cellularity and lack of marked cellular atypia in smears in common.
  • Myxoid nodular fasciitis was characterized by a pleomorphic pattern of proliferative cells and the presence of ganglion cell-like cells.
  • Myxoid liposarcoma, extraskeletal myxoid chondrosarcoma and myxofibrosarcoma were the most common myxoid sarcomas.
  • Myxoid liposarcoma exhibited branching chicken-wire like capillary vessels and/or lipoblasts; myxofibrosarcoma were prominent in both pleomorphic and atypia of the cells.
  • The data revealed that the diagnostic accuracy of FNAC was nearly 100% in differentiating benign and malignant myxoid lesions of the soft tissues.
  • The coordinate rate to the histopathology diagnosis of the common myxoid lesions of the soft tissues was above 75% (benign 71.4% and malignancy 80% respectively).
  • CONCLUSIONS: FNAC is an effective method in diagnosing myxoid lesions of soft tissue, in correlation with the clinical data and the accessory examinations.
  • FNAC can provide an objective basis for the treatment of myxoid lesions and prevention of unnecessary surgical operations.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Fibrosarcoma / pathology. Ganglion Cysts / pathology. Liposarcoma, Myxoid / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Chondrosarcoma / pathology. Chondrosarcoma / surgery. Diagnosis, Differential. Fasciitis / pathology. Fasciitis / surgery. Female. Humans. Male. Middle Aged. Myxoma / pathology. Myxoma / surgery. Prognosis. Sarcoma / pathology. Sarcoma / surgery. Young Adult

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  • (PMID = 18070452.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. de Vreeze RS, de Jong D, Haas RL, Stewart F, van Coevorden F: Effectiveness of radiotherapy in myxoid sarcomas is associated with a dense vascular pattern. Int J Radiat Oncol Biol Phys; 2008 Dec 1;72(5):1480-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of radiotherapy in myxoid sarcomas is associated with a dense vascular pattern.
  • The subgroup of myxoid liposarcoma (MLS), a sarcoma with a typical vascular crow's feet pattern, is highly radiosensitive, but a mechanism for this phenomenon is unknown.
  • [MeSH-major] Leiomyosarcoma / pathology. Leiomyosarcoma / radiotherapy. Liposarcoma, Myxoid / pathology. Liposarcoma, Myxoid / radiotherapy
  • [MeSH-minor] Adult. Aged. Chondrosarcoma / classification. Chondrosarcoma / pathology. Chondrosarcoma / radiotherapy. Chondrosarcoma / surgery. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 18448271.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Bartalena T, Rimondi E, Rossi G, Bianchi G, Alberghini M: Low grade central chondrosarcoma of the fifth costotransverse joint. Australas Radiol; 2007 Oct;51 Spec No.:B122-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low grade central chondrosarcoma of the fifth costotransverse joint.
  • Chondrosarcoma (CHS) is the third most frequent primary malignant tumour of bone exceeded only by myeloma and osteosarcoma.
  • Both CT-guided core needle biopsy and excisional biopsy were consistent with grade I central CHS with myxoid change and focal areas of Grade II CHS.
  • [MeSH-major] Chondrosarcoma / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Thoracic Vertebrae / pathology. Thoracic Vertebrae / radiography. Thoracic Vertebrae / radionuclide imaging

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  • (PMID = 17875132.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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24. Salvati M, Caroli E, Frati A, Piccirilli M, Agrillo A, Brogna C, Occhiogrosso G, Giangaspero F: Central nervous system mesenchymal chondrosarcoma. J Exp Clin Cancer Res; 2005 Jun;24(2):317-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Central nervous system mesenchymal chondrosarcoma.
  • Central nervous system mesenchymal chondrosarcomas are rare malignant tumors that constitute a separate entity from the classical chondrosarcoma and myxoid variant.
  • We describe two rare examples of intracranial mesenchymal chondrosarcoma with a review of the literature, in an attempt to clarify the clinical characteristics, prognosis and treatment of choice of these unusual tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Chondrosarcoma, Mesenchymal / diagnosis
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents. Cartilage / pathology. Cell Differentiation. Central Nervous System Neoplasms / diagnosis. Central Nervous System Neoplasms / mortality. Central Nervous System Neoplasms / therapy. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Time Factors. Treatment Outcome

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  • (PMID = 16110767.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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25. Wagnetz U, Patsios D, Darling G, Las Heras F, Hwang D: Tracheal chondrosarcoma--a rare complication in Maffucci syndrome. Br J Radiol; 2009 Aug;82(981):e178-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tracheal chondrosarcoma--a rare complication in Maffucci syndrome.
  • We present a case of an intermediate grade myxoid chondrosarcoma of the tracheal cartilage in a 34-year-old man with a history of Maffucci syndrome.
  • Chondrosarcoma of the trachea are extremely rare tumours.
  • [MeSH-major] Bone Neoplasms / radiography. Chondrosarcoma / radiography. Enchondromatosis / complications. Tracheal Neoplasms / radiography
  • [MeSH-minor] Adult. Bronchoscopy. Contrast Media. Humans. Male. Tomography, Spiral Computed / methods

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  • (PMID = 19729547.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 17
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26. Hall ND, Fabinyi G, Gul SM, Cher L, Leibsch NJ: Spinal drop metastasis from grade I skull base chondrosarcoma. J Clin Neurosci; 2010 Jan;17(1):135-7
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  • [Title] Spinal drop metastasis from grade I skull base chondrosarcoma.
  • Chondrosarcoma of the skull base is a rare tumour with a good prognosis following surgical resection.
  • We describe a patient with low-grade chondrosarcoma of the skull base with intradural extramedullary spinal metastases.
  • A 31-year-old female with grade 1 chondrosarcoma involving the cavernous sinus, sphenoid wing and clivus presented at age 19.
  • Following surgical excision of the symptomatic lesion, histological diagnosis was confirmed as a mixed hyaline/myxoid grade 1 chondrosarcoma.
  • Patients with skull base chondrosarcoma with intradural extension should have whole spine imaging as part of long-term monitoring to exclude drop metastases, particularly after intradural surgery.
  • [MeSH-major] Cervical Vertebrae / pathology. Chondrosarcoma / secondary. Neoplasm Metastasis / pathology. Skull Base / pathology. Skull Base Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Cavernous Sinus / pathology. Cavernous Sinus / surgery. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Cranial Fossa, Posterior / pathology. Cranial Fossa, Posterior / surgery. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures / methods. Paresthesia / etiology. Radiculopathy / etiology. Radiotherapy / methods. Sella Turcica / pathology. Sella Turcica / surgery. Sphenoid Bone / pathology. Sphenoid Bone / surgery. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19864142.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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27. Damron TA, Ward WG, Stewart A: Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res; 2007 Jun;459:40-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report.
  • We summarize descriptive epidemiologic and survival data from the National Cancer Data Base of the American College of Surgeons for 26,437 cases of osteosarcoma (n = 11,961), chondrosarcoma (n = 9606), and Ewing's sarcoma (n = 4870) from 1985 to 2003.
  • The relative 5-year survival rate was 53.9% for osteosarcoma, 75.2% for chondrosarcoma, and 50.6% for Ewing's sarcoma.
  • Within chondrosarcomas, the relative 5-year survival rate was 76% for conventional, 71% for myxoid, 87% for juxtacortical, and 52% for mesenchymal.
  • [MeSH-major] Bone Neoplasms / epidemiology. Chondrosarcoma / epidemiology. Osteosarcoma / epidemiology. Sarcoma, Ewing / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Child. Databases, Factual. Humans. Middle Aged. Sex Distribution. Survival Rate. United States / epidemiology


28. Misra V, Singh PA: Cytodiagnosis of extraosseous mesenchymal chondrosarcoma of meninges: a case report. Acta Cytol; 2008 May-Jun;52(3):366-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytodiagnosis of extraosseous mesenchymal chondrosarcoma of meninges: a case report.
  • BACKGROUND: Extraosseous mesenchymal chondrosarcoma (MC) is a rare neoplasm.
  • Fine needle aspiration (FNA) smears showed scant material consisting mainly of monomorphic small round cells with granular cytoplasm and central round nuclei lying in a background of myxoid matrix.
  • CONCLUSION: Extraosseous MC should be considered in FNA smears showing small round cells in a myxoid background.
  • [MeSH-major] Chondrosarcoma, Mesenchymal / pathology. Cytodiagnosis. Meningeal Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. S100 Proteins / metabolism

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  • (PMID = 18540308.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / S100 Proteins
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29. Ichimura H, Endo K, Ishikawa S, Yamamoto T, Onizuka M, Sakakibara Y: Primary chondrosarcoma of the lung recognized as a long-standing solitary nodule prior to resection. Jpn J Thorac Cardiovasc Surg; 2005 Feb;53(2):106-8
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  • [Title] Primary chondrosarcoma of the lung recognized as a long-standing solitary nodule prior to resection.
  • To make a definitive diagnosis, video-assisted thoracic surgery was performed and the lesion was diagnosed as myxoid chondrosarcoma.
  • [MeSH-major] Chondrosarcoma / diagnosis. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 15782574.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. Lamovec J, Volavsek M: Sclerosing rhabdomyosarcoma of the parotid gland in an adult. Ann Diagn Pathol; 2009 Oct;13(5):334-8
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  • [Title] Sclerosing rhabdomyosarcoma of the parotid gland in an adult.
  • We report on a parotid gland tumor characterized by infiltrative growth of primitive type of neoplastic cells showing strong and diffuse nuclear positivity for MyoD1 and myogenin and by prominent hyalinized/chondroid matrix with some myxoid foci.
  • Sclerosing rhabdomyosarcoma may cause differential diagnostic problems because it could be confounded for osteosarcoma, chondrosarcoma, and some other types of sarcoma, and as in our case, for myxofibrosarcoma and myoepithelial carcinoma.
  • Its location in the head and neck is of special interest because 6 of 14 previously described adult cases of sclerosing rhabdomyosarcoma and 7 of 18 pediatric cases also occurred in this region.

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  • (PMID = 19751910.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein
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31. Manna AK, Chattopadhyay A, Chowdhury K, Chowdhury MK, Dutta SK: Chondroid lipoma--a case report. Indian J Pathol Microbiol; 2006 Jul;49(3):422-4

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  • Though it is clinically benign, the main importance lies in its histological similarity with myxoid liposarcoma and chondrosarcoma, which have poorer prognosis.
  • [MeSH-major] Chondrosarcoma / pathology. Lipoma / pathology. Muscle Neoplasms / pathology. Thigh
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Muscle, Skeletal / pathology

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  • (PMID = 17001908.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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32. Sangoi AR, Dulai MS, Beck AH, Brat DJ, Vogel H: Distinguishing chordoid meningiomas from their histologic mimics: an immunohistochemical evaluation. Am J Surg Pathol; 2009 May;33(5):669-81
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  • As such, recognition of this entity is important in cases that show similar morphologic overlap with other chondroid/myxoid neoplasms that can arise within or near the central nervous system.
  • In this study, immunohistochemical staining was performed with antibodies against D2-40, S100, pankeratin, epithelial membrane antigen (EMA), brachyury, and glial fibrillary acidic protein (GFAP) in 4 cases of chordoid glioma, 6 skeletal myxoid chondrosarcomas, 10 chordoid meningiomas, 16 extraskeletal myxoid chondrosarcoma, 18 chordomas, 22 low-grade chondrosarcomas, and 27 enchondromas.
  • Immunostaining with D2-40 showed positivity in 100% of skeletal myxoid chondrosarcomas, 96% of enchondromas, 95% of low-grade chondrosarcomas, 80% of chordoid meningiomas, and 75% of chordoid gliomas.
  • Staining with S100 demonstrated diffuse, strong positivity in all (100%) chordoid gliomas, skeletal myxoid chondrosarcomas, low-grade chondrosarcomas, and enchondromas, 94% of chordomas, and 81% of extraskeletal myxoid chondrosarcomas, with focal, moderate staining in 40% of chordoid meningiomas.
  • Pankeratin highlighted 100% of chordoid gliomas and chordomas, 38% of extraskeletal myxoid chondrosarcomas, and 20% of chordoid meningiomas.
  • EMA staining was positive in 100% of chordoid gliomas, 94% of chordomas, 90% of chordoid meningiomas, and 25% of extraskeletal myxoid chondrosarcomas.
  • EMA was the most effective antibody for differentiating chordoid meningioma from skeletal myxoid chondrosarcoma, low-grade chondrosarcoma, and enchondroma, whereas D2-40 was the most effective antibody for differentiating chordoid meningioma from extraskeletal myxoid chondrosarcoma and chordoma.
  • Our findings demonstrate that in conjunction with clinical and radiographic findings, immunohistochemical evaluation with a panel of D2-40, EMA, brachyury, and GFAP is most useful in distinguishing chordoid meningioma from chordoid glioma, skeletal myxoid chondrosarcoma, extraskeletal myxoid chondrosarcoma, chordoma, low-grade chondrosarcoma, and enchondroma.
  • Of note, this study is the first to characterize the D2-40 immunoprofile in extraskeletal myxoid chondrosarcoma, results that could be of utility in differential diagnostic assessment.
  • [MeSH-minor] Adolescent. Adult. Aged. Antibodies, Monoclonal. Antibodies, Monoclonal, Murine-Derived. Child. Chondroma / chemistry. Chondroma / pathology. Chondrosarcoma / chemistry. Chondrosarcoma / pathology. Diagnosis, Differential. Female. Fetal Proteins / analysis. Glial Fibrillary Acidic Protein / analysis. Glioma / chemistry. Glioma / pathology. Humans. Keratins / analysis. Male. Middle Aged. Mucin-1 / analysis. Predictive Value of Tests. S100 Proteins / analysis. T-Box Domain Proteins / analysis. Young Adult

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  • (PMID = 19194275.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NLM NIH HHS / LM / T15 LM007033
  • [Publication-type] Comparative Study; Journal Article; Meta-Analysis
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Brachyury protein; 0 / Fetal Proteins; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 0 / S100 Proteins; 0 / T-Box Domain Proteins; 0 / monoclonal antibody D2-40; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ NIHMS775584; NLM/ PMC4847145
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33. Powers JW, Teitell M, Milisavljevic V: Congenital high-grade sarcoma presenting as skin nodules and respiratory distress in a neonate. J Perinatol; 2008 Feb;28(2):160-2
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  • We report, to our knowledge, the first case of a congenital, widespread, aggressive high-grade sarcoma, presented as multiple skin nodules and respiratory distress in a neonate that had a t(9;22)(q22;q11-12) cytogenetic abnormality suggestive of a more indolent extraskeletal myxoid chondrosarcoma (EMC).
  • [MeSH-major] Chondrosarcoma / congenital. Chondrosarcoma / diagnosis. Respiratory Insufficiency / etiology. Skin Neoplasms / congenital. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Infant, Newborn. Male

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  • (PMID = 18235511.001).
  • [ISSN] 0743-8346
  • [Journal-full-title] Journal of perinatology : official journal of the California Perinatal Association
  • [ISO-abbreviation] J Perinatol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA107300; United States / NCI NIH HHS / CA / CA90571; United States / NICHD NIH HHS / HD / K12HD034610-11
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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34. Bifulco K, De Chiara A, Fazioli F, Longanesi-Cattani I, Cantelmo AR, Tirino V, Apice G, Rocco G, Lombardi ML, Carriero MV: Cell invasiveness in sarcomas: a possibly useful clinical correlation. Tumori; 2008 Jul-Aug;94(4):505-10
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  • [MeSH-minor] Adolescent. Adult. Aged. Chondrosarcoma / pathology. Collagen. Disease Progression. Disease-Free Survival. Drug Combinations. Female. Fibroma / pathology. Fibrosarcoma / pathology. Humans. Immunohistochemistry. Laminin. Liposarcoma, Myxoid / pathology. Male. Middle Aged. Neoplasm Invasiveness. Predictive Value of Tests. Prognosis. Proteoglycans. Tumor Cells, Cultured

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  • (PMID = 18822686.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Laminin; 0 / Proteoglycans; 119978-18-6 / matrigel; 9007-34-5 / Collagen
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35. Li BZ, Wang JW, Wei HQ: [Microcystic/reticular schwannoma occurring in cervical spine: report of a case with literature review]. Zhonghua Bing Li Xue Za Zhi; 2010 Jun;39(6):396-9
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  • The other component consisted of epithelial-like cells arranged in a reticular or lace-like pattern, amongst a myxoid matrix.
  • [MeSH-minor] Adult. Chondrosarcoma / metabolism. Chondrosarcoma / pathology. Chordoma / metabolism. Chordoma / pathology. Diagnosis, Differential. Glial Fibrillary Acidic Protein / metabolism. Humans. Male. Phosphopyruvate Hydratase / metabolism. S100 Proteins / metabolism. Sarcoma / metabolism. Sarcoma / pathology. Vimentin / metabolism

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  • (PMID = 21055157.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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36. DiFrancesco LM, Davanzo Castillo CA, Temple WJ: Extra-axial chordoma. Arch Pathol Lab Med; 2006 Dec;130(12):1871-4
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  • Other neoplasms with a similar histologic picture but an extra-axial location have been described, including parachordoma, myxoid chondrosarcoma, and extra-axial chordoma.
  • Parachordoma and myxoid chondrosarcoma were excluded from the differential diagnosis.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography

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  • (PMID = 17149966.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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37. Sigauke E, Rakheja D, Maddox DL, Hladik CL, White CL, Timmons CF, Raisanen J: Absence of expression of SMARCB1/INI1 in malignant rhabdoid tumors of the central nervous system, kidneys and soft tissue: an immunohistochemical study with implications for diagnosis. Mod Pathol; 2006 May;19(5):717-25
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  • In total, 12 brain, three renal and two soft tissue rhabdoid tumors were examined along with four glioblastomas, four pilocytic astrocytomas, four oligodendrogliomas, two ependymomas, two choroid plexus papillomas, five pituitary adenomas, four germinomas, four renal carcinomas with Xp11.2 translocations, two clear cell sarcomas, two Wilms' tumors, one renal medullary carcinoma, two desmoplastic small round cell tumors, two alveolar rhabdomyosarcomas, two embryonal rhabdomyosarcomas, one low-grade chondrosarcoma, two extraskeletal myxoid chondrosarcomas, one mesenchymal chondrosarcoma, four malignant peripheral nerve sheath tumors, five metastatic carcinomas and four epithelioid sarcomas, two primary and two metastatic.
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Child. Child, Preschool. Chromosomal Proteins, Non-Histone. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Middle Aged

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  • (PMID = 16528370.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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38. Pai MR, Naik R, Kamath R, Magar D: Myoepithelioma of soft tissue. Indian J Pathol Microbiol; 2009 Jan-Mar;52(1):100-2
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  • With a clinical diagnosis of chondrosarcoma, the tumor with the surrounding tissue was resected in segments at surgery.
  • Histomorphology revealed nests, sheets and cords of round to spindled cells with extensive squamous metaplasia in a myxoid to fibrous stroma.
  • [MeSH-minor] Adult. Female. Humans. Keratins / analysis. Magnetic Resonance Imaging

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  • (PMID = 19136797.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 68238-35-7 / Keratins
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39. Kilpatrick SE, Bergman S, Pettenati MJ, Gulley ML: The usefulness of cytogenetic analysis in fine needle aspirates for the histologic subtyping of sarcomas. Mod Pathol; 2006 Jun;19(6):815-9
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  • The study sample included eight Ewing sarcomas, six synovial sarcomas, five rhabdomyosarcomas, two myxoid liposarcomas, and one each of myxoid chondrosarcoma, osteosarcoma, and atypical lipoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle / methods. Child. Child, Preschool. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 18 / genetics. Chromosomes, Human, Pair 22. Chromosomes, Human, X / genetics. Cytogenetic Analysis / methods. Female. Humans. Male. Middle Aged. Retrospective Studies. Translocation, Genetic

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  • (PMID = 16557276.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA: C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Genes Chromosomes Cancer; 2010 Sep;49(9):810-8
SciCrunch. HGNC: Data: Gene Annotation .

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  • Chondroid lipoma, a rare benign adipose tissue tumor, may histologically resemble myxoid liposarcoma or extraskeletal myxoid chondrosarcoma, but is genetically distinct.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20607705.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA036727-24S59009; United States / NCI NIH HHS / CA / 5 P30 CA036727-2452; United States / NCI NIH HHS / CA / P30 CA036727-24S59009; United States / NCI NIH HHS / CA / U-10-CA98543-091
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MKL2 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Transcription Factors
  • [Other-IDs] NLM/ NIHMS203810; NLM/ PMC2904421
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41. Bergmann M, Abdalla Y, Neubauer U, Schildhaus HU, Probst-Cousin S: Primary intradural chordoma: report on three cases and review of the literature. Clin Neuropathol; 2010 May-Jun;29(3):169-76
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  • RESULTS: All cases showed the typical histological picture with physaliphorous cells in a myxoid matrix and the characteristic immunohistochemical profile with positivity for vimentin, pancytokeratin, CK19, EMA, and S100.
  • Myxoid extraskeletal chondrosarcoma was excluded by in-situ-hybridization of the EWS gene.
  • [MeSH-minor] Adult. Aged. Biopsy. Female. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 20423692.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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42. Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF: Why do patients with low-grade soft tissue sarcoma die? Ann Surg Oncol; 2008 Dec;15(12):3550-60
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  • Conversely, of DODR, extremity (47%) and trunk (18%) were the most common sites, but histology was more variable [liposarcoma 35%, malignant fibrous histiocytoma (MFH) 20%, fibrosarcoma 12%, extraskeletal myxoid chondrosarcoma 10%].

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  • (PMID = 18830667.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA047179-09; United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA 047179; United States / NCI NIH HHS / CA / P01 CA047179-09
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS75337; NLM/ PMC2605207
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43. Moore LF, Kransdorf MJ, Buskirk SJ, O'Connor MI, Menke DM: Radiation-induced pseudotumor following therapy for soft tissue sarcoma. Skeletal Radiol; 2009 Jun;38(6):579-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary tumors were malignant fibrous histiocytoma (n = 13), leiomyosarcoma (n = 6), liposarcoma (n = 3), synovial sarcoma (n = 1), and extraskeletal chondrosarcoma (n = 1).
  • All lesions were high-grade sarcomas, except for two myxoid liposarcomas.
  • [MeSH-minor] Adult. Aged. Comorbidity. Female. Florida / epidemiology. Humans. Incidence. Male. Middle Aged. Retrospective Studies. Risk Assessment / methods. Risk Factors

  • Genetic Alliance. consumer health - Soft tissue sarcoma.
  • MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.
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  • (PMID = 19221738.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Zhang SK, Wang JG, Piao YS, Lu DH: A case of myxoid chondrosarcoma arising from caput costae. Ai Zheng; 2009 Aug;28(8):894-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of myxoid chondrosarcoma arising from caput costae.
  • [MeSH-major] Bone Neoplasms / diagnosis. Chondrosarcoma / diagnosis. Ribs
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived / metabolism. Cell Nucleus / metabolism. Cytoplasm / metabolism. Humans. Magnetic Resonance Imaging. Male. S100 Proteins / metabolism. Tomography, X-Ray Computed. Vimentin / metabolism

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  • (PMID = 20380079.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal, Murine-Derived; 0 / S100 Proteins; 0 / Vimentin; 0 / monoclonal antibody D2-40
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