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Items 1 to 100 of about 414
1. Deniz K, Kontas O, Tucer B, Kurtsoy A: Meningeal solitary fibrous tumor: report of a case and literature review. Folia Neuropathol; 2005;43(3):178-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningeal solitary fibrous tumor: report of a case and literature review.
  • Solitary fibrous tumor is a rare neoplasm that most often involves the pleura.
  • Histologically, the tumor composed of spindle cell proliferation.
  • Tumor cells were found to be positive for CD34 and CD117 with immunohistochemical studies.
  • Seventy seven cases of meningeal solitary fibrous tumor from the literature are analysed and pathological, immunohistochemical and clinical features are discussed.
  • Solitary fibrous tumor has a slight female predominance, with a male to female ratio of 1:1.5.
  • Approximately 23% of cases originate in the spine which is the most common meningeal location.
  • A differential diagnosis is important because most of the solitary fibrous tumors usually behave in a benign fashion.
  • In this study, we also showed CD117 (Kit) expression in a case of meningeal SFT.

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  • (PMID = 16245214.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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2. Moser T, Nogueira TS, Fakhoury W, Pfleger N, Neuville A, Kehrli P, Beltechi R, Serban A, Silvestre R, Dietemann JL: [Primary meningeal intermediate grade melanocytic neoplasm: case report with radiologic-pathologic correlation]. J Neuroradiol; 2005 Jan;32(1):59-62
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  • [Title] [Primary meningeal intermediate grade melanocytic neoplasm: case report with radiologic-pathologic correlation].
  • A case of primary meningeal intermediate grade melanocytic neoplasm involving the right C2 nerve root is presented.
  • Cellularity, pleomorphism, mitotic rate, proliferation index and invasiveness are useful criteria to distinguish among the spectrum of primary melanocytic tumors of the central nervous system ranging from melanocytoma to malignant melanoma.
  • [MeSH-major] Melanoma / diagnosis. Meningeal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 15798616.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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3. Shi Q, Pu CQ, Wu WP, Huang XS, Yu SY, Tian CL, Huang DH, Zhang JT: [Value of tumor markers in the cerebrospinal fluid in the diagnosis of meningeal carcinomatosis]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 May;30(5):1192-4
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  • [Title] [Value of tumor markers in the cerebrospinal fluid in the diagnosis of meningeal carcinomatosis].
  • OBJECTIVE: To assess the diagnostic value of tumor markers in the cerebrospinal fluid (CSF) for meningeal carcinomatosis (MC).
  • METHODS: Twenty-one MC patients (including 13 adenocarcinoma and 8 non-adenocarcinoma patients), 72 patients with tuberculous meningitis (TBM) and 23 with primary intracerebral tumors (PIT) were enrolled in this study.
  • Blood and CSF tumor markers including CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP and NSE were measured by Roche E170 electrochemiluminescence analyzer and sandwich assay.
  • RESULTS: CSF tumor markers CEA, CA125, CA199 and CYFRA21-1 and the serum tumor markers CEA, CA125, CA153, CA199 and AFP were significantly higher in MC group than in the other two groups.
  • CSF CEA and CA15-3 were significantly higher in adenocarcinoma MC than in non-adenocarcinoma MC patients, but no significant differences were found in the serum tumor markers between the two groups (P>0.05).
  • CSF tumor markers including CEA, CA125, CA15-3, CA72-4 and CYFRA21-1 were positively correlated to the serum tumor markers (P<0.05).
  • CONCLUSION: Detection of the tumor markers in the CSF, especially CEA, CA125, CA19-9 and CYFRA21-1, may help in the early diagnosis of MC.
  • [MeSH-major] Biomarkers, Tumor / cerebrospinal fluid. Meningeal Neoplasms / cerebrospinal fluid. Meningeal Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / cerebrospinal fluid. Adenocarcinoma / diagnosis. Adult. Aged. Antigens, Neoplasm / cerebrospinal fluid. CA-125 Antigen / cerebrospinal fluid. CA-19-9 Antigen / cerebrospinal fluid. Carcinoembryonic Antigen / cerebrospinal fluid. Female. Humans. Keratin-19 / cerebrospinal fluid. Male. Membrane Proteins / cerebrospinal fluid. Middle Aged. Young Adult

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  • (PMID = 20501426.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Keratin-19; 0 / MUC16 protein, human; 0 / Membrane Proteins; 0 / antigen CYFRA21.1
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4. Puri S, Joshi BH, Sarkar C, Mahapatra AK, Hussain E, Sinha S: Expression and structure of interleukin 4 receptors in primary meningeal tumors. Cancer; 2005 May 15;103(10):2132-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and structure of interleukin 4 receptors in primary meningeal tumors.
  • BACKGROUND: It was reported previously that malignant human tumors, like glioma and medulloblastoma, express high-density interleukin (IL-4) receptor mRNA and protein.
  • Because IL-4 receptors (R) are sensitive targets for targeted therapeutics, knowledge of the expression of these receptors in other central nervous system tumors is of great interest.
  • METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) analysis for IL-13Ralpha1, IL-4Ralpha and IL-2Rgammac was performed on total RNA extracted from 35 meningiomas and a normal human brain tissue sample.
  • Results were confirmed in nine randomly selected tumors by quantitative real-time PCR and in situ immunofluorescence assay.
  • RESULTS: Transcripts for the IL-4Ralpha and IL-13Ralpha1 chains were overexpressed in meningiomas compared with normal brain tissue.
  • The results also showed that tumors with higher disease grade tended to have increased mRNA expression for the IL-4Ralpha chain.
  • The transcripts for IL-2Rgammac chain were not detected in any of the tumor samples or in normal brain tissue.
  • These receptors may serve as a target for cytotoxin/immunotoxin therapy in patients with meningioma who are not amenable to surgical resection or for recurrent tumors.
  • [MeSH-major] Meningeal Neoplasms / chemistry. Meningioma / chemistry. Receptors, Interleukin-4 / chemistry
  • [MeSH-minor] Adult. Age Factors. Brain Chemistry. Fluorescent Antibody Technique. Gene Expression Regulation, Neoplastic. Humans. Interleukin Receptor Common gamma Subunit. Interleukin-13 / chemistry. Interleukin-13 Receptor alpha1 Subunit. Middle Aged. RNA, Messenger / analysis. Receptors, Interleukin / chemistry. Receptors, Interleukin-13. Receptors, Interleukin-2 / chemistry. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15830341.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / IL13RA1 protein, human; 0 / IL2RG protein, human; 0 / Interleukin Receptor Common gamma Subunit; 0 / Interleukin-13; 0 / Interleukin-13 Receptor alpha1 Subunit; 0 / RNA, Messenger; 0 / Receptors, Interleukin; 0 / Receptors, Interleukin-13; 0 / Receptors, Interleukin-2; 0 / Receptors, Interleukin-4
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5. Perry A, Fuller CE, Judkins AR, Dehner LP, Biegel JA: INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas. Mod Pathol; 2005 Jul;18(7):951-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas.
  • Rhabdoid cells are encountered in specific entities, such as malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor, as well as in composite rhabdoid tumors derived secondarily from other tumor types.
  • Although rhabdoid tumors are uniformly aggressive, distinction of the entity from the phenotype remains important for its therapeutic implications.
  • The majority of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors affect infants and young children, harbor chromosome 22q deletions, and inactivate the INI1/hSNF5/BAF47 tumor suppressor gene on 22q11.2.
  • In contrast, most composite rhabdoid tumors are diagnosed in adults, with FISH detectable 22q losses the exception rather than the rule.
  • However, this assay remains limited since 22q dosages are maintained in 20-30% of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors.
  • Furthermore, chromosome 22 losses are common in some parent tumor types, particularly meningiomas.
  • The recently developed INI1 antibody shows loss of nuclear expression in malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors, though its status in composite rhabdoid tumors is largely unknown.
  • Therefore, we utilized immunohistochemistry and FISH to study INI1 expression and 22q dosages, respectively, in 40 composite rhabdoid tumors, including 16 meningiomas, 15 carcinomas, three melanomas, two sarcomas, two glioblastomas, and 1 neuroblastoma.
  • Approximately 70% of rhabdoid meningiomas had a 22q deletion, but this was rare in other tumor types.
  • Except for one retroperitoneal leiomyosarcoma, nuclear INI1 expression was retained in all composite rhabdoid tumors, including meningiomas with 22q deletion.
  • Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor.
  • [MeSH-major] DNA-Binding Proteins / biosynthesis. Meningeal Neoplasms / pathology. Meningioma / pathology. Rhabdoid Tumor / pathology
  • [MeSH-minor] Adult. Aged. Child. Chromosomal Proteins, Non-Histone. Chromosome Deletion. Chromosomes, Human, Pair 22 / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Male. Middle Aged. Transcription Factors

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  • (PMID = 15761491.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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6. Samanic CM, De Roos AJ, Stewart PA, Rajaraman P, Waters MA, Inskip PD: Occupational exposure to pesticides and risk of adult brain tumors. Am J Epidemiol; 2008 Apr 15;167(8):976-85
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  • [Title] Occupational exposure to pesticides and risk of adult brain tumors.
  • The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer.

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  • (PMID = 18299277.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / ZIA CP010135-18; United States / NCI NIH HHS / CP / N01-CP-15679-01
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pesticides
  • [Other-IDs] NLM/ NIHMS565764; NLM/ PMC3967588
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7. Ambrosini-Spaltro A, Eusebi V: Meningeal hemangiopericytomas and hemangiopericytoma/solitary fibrous tumors of extracranial soft tissues: a comparison. Virchows Arch; 2010 Apr;456(4):343-54
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  • [Title] Meningeal hemangiopericytomas and hemangiopericytoma/solitary fibrous tumors of extracranial soft tissues: a comparison.
  • The current World Health Organization (WHO) classification of central nervous system tumors lists meningeal hemangiopericytomas (HPC) and meningeal solitary fibrous tumors (SFT) as separate entities.
  • The clinical data, histology, and immunohistochemistry of 18 cases of meningeal HPC and 12 cases of peripheral soft tissue HPC-SFT were compared.
  • Nevertheless, intracranial tumors were more cellular than HPC-SFT of soft tissues and had fewer collagen bands.
  • Meningeal HPC in addition had more mitoses, higher Ki67 index, stained less intensely for CD34 and B-cell lymphoma 2 (BCL2) than HPC-SFT of soft tissues.
  • Meningeal HPCs recurred in 13 out of 14 cases (92.9%).
  • Both meningeal and soft tissue tumors appear to represent different features of the same entity.
  • A more aggressive phenotype of the tumor together with incomplete surgical resection of intracranial lesions might explain the noticeable clinical difference between HPC of the meninges and HPC-SFT of soft tissues.
  • [MeSH-major] Hemangiopericytoma / pathology. Meningeal Neoplasms / pathology. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / metabolism. Collagen / metabolism. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / metabolism. Recurrence. Retrospective Studies. Young Adult

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  • (PMID = 20165866.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Proto-Oncogene Proteins c-bcl-2; 9007-34-5 / Collagen
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8. Hattori K, Miyachi S, Kobayashi N, Kojima T, Hattori K, Negoro M, Yoshida J, Nagasaka T: Contralateral meningeal artery supply of paramedian meningiomas. Surg Neurol; 2005 Sep;64(3):242-8; discussion 248

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contralateral meningeal artery supply of paramedian meningiomas.
  • BACKGROUND: When resecting at falcine or parasagittal portion of paramedian meningiomas, intraoperative hemostasis often is difficult despite effective management of ipsilateral meningeal arteries.
  • We attribute such difficulties to meningeal artery blood supply from the contralateral side.
  • We retrospectively studied feeding arteries from both sides in case of paramedian meningioma in terms of patient and tumor characteristics.
  • We investigated how contralateral meningeal arterial feeders related to patient profiles and imaging, histopathologic, and immunohistochemical findings.
  • RESULTS: Contralateral meningeal supply existed for 14 of 25 falcine meningiomas and 6 of 18 parasagittal meningiomas.
  • Patients with contralateral feeders were 8.5 years younger than the others (P=.027) and were more likely to have larger tumors (P=.028).
  • CONCLUSIONS: Contralateral meningeal supply may reflect strong angiogenetic recruitment from rapid tumor growth followed by high expression of vascular endothelial growth factor.
  • [MeSH-major] Meningeal Arteries / radiography. Meningeal Neoplasms / blood supply. Meningeal Neoplasms / diagnosis. Meningioma / blood supply. Meningioma / diagnosis
  • [MeSH-minor] Adult. Age Factors. Aged. Antibodies, Antinuclear / metabolism. Antibodies, Monoclonal / metabolism. Antigens, CD34 / metabolism. Female. Humans. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Sex Factors. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 16099256.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Antigens, CD34; 0 / MIB-1 antibody; 0 / Vascular Endothelial Growth Factor A
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9. Hong B, Hermann EJ, Hollwitz B, Klein R, Agaronjan A, Krauss JK: Primary meningeal sarcoma with leiomyoblastic differentiation complicating pregnancy. Clin Neurol Neurosurg; 2010 Jul;112(6):516-9
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  • [Title] Primary meningeal sarcoma with leiomyoblastic differentiation complicating pregnancy.
  • Intracranial malignant tumors during pregnancy are rare.
  • Primary meningeal sarcoma with leiomyoblastic differentiation during pregnancy has not been reported.
  • We present the case of a 25-year-old woman in the third trimester of pregnancy with a large intracranial tumor destructing the parietal calvaria and invasion of soft tissues.
  • Histological examination revealed primary meningeal sarcoma with leiomyoblastic differentiation.
  • A gross macroscopical resection of the tumor with removal of the infiltrated parietal calvaria was performed after delivery of a healthy baby through caesarean section.
  • Early radiological exams as well as tumor resection followed by staging and multimodality treatment should be urgently performed.
  • [MeSH-major] Leiomyoma, Epithelioid / complications. Meningeal Neoplasms / complications. Pregnancy Complications, Neoplastic / pathology. Sarcoma / complications
  • [MeSH-minor] Adult. Brain / pathology. Cesarean Section. Combined Modality Therapy. Fatal Outcome. Female. Humans. Infant, Newborn. Magnetic Resonance Imaging. Pregnancy. Pregnancy Outcome

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20399009.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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10. Sun S, Liu A, Wang C: Gamma knife radiosurgery for recurrent and residual meningeal hemangiopericytomas. Stereotact Funct Neurosurg; 2009;87(2):114-9

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  • [Title] Gamma knife radiosurgery for recurrent and residual meningeal hemangiopericytomas.
  • AIMS: The aim of this study was to assess the clinical effects of Gamma Knife radiosurgery (GKS) for recurrent and residual meningeal hemangiopericytomas (M-HPC).
  • The mean volume of these tumors was 5.4 cm(3) (range 0.1-37.2 cm(3)).
  • The mean tumor margin dose was 13.5 Gy (range 10.0-20.0 Gy).
  • The mean tumor central dose was 28.2 Gy (range 21.8-35.0 Gy).
  • The overall tumor control rate was 89.7%.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Survival Rate. Young Adult

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  • [Copyright] (c) 2009 S. Karger AG, Basel.
  • (PMID = 19223698.001).
  • [ISSN] 1423-0372
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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11. Inci S, Bozkurt G, Gulsen S, Firat P, Ozgen T: Rare cause of subarachnoid hemorrhage: spinal meningeal carcinomatosis. Case report. J Neurosurg Spine; 2005 Jan;2(1):79-82
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  • [Title] Rare cause of subarachnoid hemorrhage: spinal meningeal carcinomatosis. Case report.
  • Although primary spinal tumors, especially ependymomas, are also relatively common causes, SAH secondary to a metastatic spinal tumor arising from outside the central nervous system is an extremely rare condition; only one case has been reported in the literature.
  • The authors present a case of spinal meningeal carcinomatosis secondary to cutaneous malignant melanoma in which the patient presented with only symptoms of SAH.
  • [MeSH-major] Carcinoma / complications. Melanoma / secondary. Meningeal Neoplasms / complications. Skin Neoplasms / pathology. Spinal Neoplasms / complications. Subarachnoid Hemorrhage / etiology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 15658132.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Gupta A, Ahmad FU, Sharma MC, Garg A, Mehta VS: Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report. J Neurosurg; 2007 Jun;106(6):1094-7
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  • [Title] Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report.
  • Meningeal melanocytomas are uncommon intracranial tumors and their occurrence at the cerebellopontine angle (CPA) is extremely rare.
  • The authors describe the case of a 58-year-old woman who presented with a left CPA tumor; on the basis of histopathological studies after resection, a diagnosis of meningeal melanocytoma was reached.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Melanins / metabolism. Neurosurgical Procedures

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  • (PMID = 17564187.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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13. Fagundes-Pereyra WJ, de Sousa L, Carvalho GT, Pittella JE, de Sousa AA: Meningeal melanocytoma of the posterior fossa: case report and literature review. Surg Neurol; 2005 Mar;63(3):269-73; discussion 273-4

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  • [Title] Meningeal melanocytoma of the posterior fossa: case report and literature review.
  • BACKGROUND: Meningeal melanocytomas are rare primary melanotic tumors of the leptomeninges.
  • According to our review of the literature, just 22 cases of meningeal melanocytoma (MM) of the posterior fossa have been previously reported.
  • CONCLUSIONS: In conclusion, MMs are rare histologically benign tumors that can be cured by complete surgical resection alone, which should be the goal of the treatment.
  • These lesions, although rare, should be considered in the differential diagnosis of tumors of the posterior fossa.
  • [MeSH-major] Cerebellum / pathology. Cranial Fossa, Posterior / pathology. Infratentorial Neoplasms / pathology. Melanocytes / pathology. Meningeal Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Diagnosis, Differential. Disease-Free Survival. Female. Headache / etiology. Humans. Magnetic Resonance Imaging. Nausea / etiology. Neurosurgical Procedures / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15734524.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 29
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14. Aghi M, Barker FG 2nd: Benign adult brain tumors: an evidence-based medicine review. Prog Neurol Surg; 2006;19:80-96
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  • [Title] Benign adult brain tumors: an evidence-based medicine review.
  • BACKGROUND: Benign adult brain tumors can be managed conservatively or using surgery, radiation, or medicines.
  • While randomized comparisons assessing tumor recurrence, quality of life, or survival are the ideal means of comparing treatments, it can be difficult to recruit patients to such trials and lengthy follow-up periods are needed because of the slowly progressive natural history of these tumors.
  • METHODS: Review of the literature on benign adult brain tumors using evidence-based standards and focusing on meningiomas, pituitary adenomas, and vestibular schwannomas, which together represent the majority of WHO grade 1 adult brain tumors.
  • RESULTS: Nearly all studies of benign adult brain tumors were of relatively poor quality (level 3 or poorer).
  • CONCLUSIONS: While randomized clinical trials comparing conservative management, surgery, radiation, and medical management of benign adult benign tumors are unlikely to occur, there is some level 3 evidence that can assist in their treatment.
  • [MeSH-major] Brain Neoplasms / therapy. Evidence-Based Medicine
  • [MeSH-minor] Adenoma / therapy. Adult. Humans. Meningeal Neoplasms / therapy. Meningioma / therapy. Neuroma, Acoustic / therapy. Neurosurgical Procedures. Phototherapy. Pituitary Neoplasms / therapy. Radiosurgery

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  • (PMID = 17033148.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 58
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15. Coca S, Salas I, Martínez R, Saez MA, Vaquero J: Meningeal Castleman's disease with multifocal involvement: a case report and review of literature. J Neurooncol; 2008 May;88(1):37-41
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  • [Title] Meningeal Castleman's disease with multifocal involvement: a case report and review of literature.
  • Although intracranial location is very uncommon, it should be considered in the differential diagnosis of meningeal tumors.
  • This multifocal meningeal involvement can be considered as an exceptional form of presentation of intracranial Castleman's disease.
  • [MeSH-major] Giant Lymph Node Hyperplasia / pathology. Meningeal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Meningioma / diagnosis. Meningioma / pathology. Paresis / etiology. Tomography, X-Ray Computed

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  • (PMID = 18204819.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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16. Kleinerman RA, Linet MS, Hatch EE, Tarone RE, Black PM, Selker RG, Shapiro WR, Fine HA, Inskip PD: Self-reported electrical appliance use and risk of adult brain tumors. Am J Epidemiol; 2005 Jan 15;161(2):136-46
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  • [Title] Self-reported electrical appliance use and risk of adult brain tumors.
  • The authors investigated whether appliances may be associated with adult brain tumors in a hospital-based case-control study at three centers in the United States from 1994 to 1998.
  • There was little evidence of association between brain tumors and curling iron, heating pad, vibrating massager, electric blanket, heated water bed, sound system, computer, television, humidifier, microwave oven, and electric stove.
  • Overall, results indicate that extremely low frequency electromagnetic fields from commonly used household appliances are unlikely to increase the risk of brain tumors.
  • [MeSH-major] Brain Neoplasms / etiology. Glioma / etiology. Household Articles. Meningeal Neoplasms / etiology. Meningioma / etiology. Neuroma, Acoustic / etiology
  • [MeSH-minor] Adolescent. Adult. Case-Control Studies. Electromagnetic Fields / adverse effects. Female. Humans. Male. Middle Aged. Neoplasms, Radiation-Induced / etiology. Odds Ratio. Risk Factors

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  • (PMID = 15632263.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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17. Navas M, Pascual JM, Fraga J, Pedrosa M, Shakur S, Carrasco R, Martínez P, Manzanares R, de Sola RG: Intracranial intermediate-grade meningeal melanocytoma with increased cellular proliferative index: an illustrative case associated with a nevus of Ota. J Neurooncol; 2009 Oct;95(1):105-115
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  • [Title] Intracranial intermediate-grade meningeal melanocytoma with increased cellular proliferative index: an illustrative case associated with a nevus of Ota.
  • Solitary primary melanocytic tumors of the central nervous system (CNS) represent a spectrum of lesions ranging from well-differentiated melanocytoma to melanoma.
  • The association of a meningeal melanocytoma with an ipsilateral nevus of Ota is extremely rare, with only six cases reported in the literature to date.
  • Only a minority of melanocytic tumors correspond to lesions of intermediate-grade malignancy, whose biological behavior and outcome remain undetermined.
  • We report a new case of a 25-year-old man with a giant fronto-temporal intracranial meningeal melanocytoma associated with a congenital nevus of Ota, who suffered an acute neurological deterioration requiring an emergent surgical procedure.
  • To our knowledge, this is the first case of a meningeal melanocytoma of intermediate grade associated with a nevus of Ota reported in the literature.
  • [MeSH-major] Melanoma / pathology. Meningeal Neoplasms / pathology. Nevus of Ota / pathology
  • [MeSH-minor] Adult. Humans. Male. Nevus, Pigmented / surgery. Radiography. Tomography Scanners, X-Ray Computed

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  • (PMID = 19449182.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Poliani PL, Sperli D, Valentini S, Armentano A, Bercich L, Bonetti MF, Corriero G, Brisigotti M, Quattrone A, Lanza PL: Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case. Neuropathology; 2009 Oct;29(5):574-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case.
  • Cerebral and spinal location of glioneuronal tumors have been recently described as a novel type of primary CNS neoplasia.
  • A distinctive rare form of glioneuronal tumors with neuropil-like islands (GTNI) have been reported to occur in the adult cerebrum, whereas spinal GTNI localization is extremely rare.
  • In the present report we describe a case of a 15-month-old child with a spinal GTNI of the cervical region and meningeal dissemination.
  • Histologically the tumor was composed of round, small neurocytic-like cells arranged around eosinophilic neuropil cores and embedded in a diffuse fibrillar glial component forming prominent "rosetted" neuropil islands displaying strong immunoreactivity for neuronal markers.
  • [MeSH-major] Brain Neoplasms / secondary. Meningeal Neoplasms / secondary. Neoplasms, Nerve Tissue / pathology. Spinal Neoplasms / pathology

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  • (PMID = 19077041.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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19. Reis F, Faria AV, Zanardi VA, Menezes JR, Cendes F, Queiroz LS: Neuroimaging in pineal tumors. J Neuroimaging; 2006 Jan;16(1):52-8
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  • [Title] Neuroimaging in pineal tumors.
  • BACKGROUND AND PURPOSE: The authors report radiological findings in 11 tumors in the pineal region, which were histologically diagnosed as germinomas, pineocytomas pineoblastomas, ependymomas, teratomas, and astrocytomas.
  • CONCLUSIONS: Pineal region tumors have no pathognomonic imaging pattern.
  • MRI and CT are complementary in diagnosis and are important to determine localization, extension, and meningeal spread.
  • [MeSH-major] Brain Neoplasms / diagnosis. Pineal Gland / pathology. Pinealoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Child. Diagnosis, Differential. Ependymoma / diagnosis. Female. Germinoma / diagnosis. Humans. Magnetic Resonance Imaging. Male. Neuroblastoma / diagnosis. Prognosis. Teratoma / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16483277.001).
  • [ISSN] 1051-2284
  • [Journal-full-title] Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • [ISO-abbreviation] J Neuroimaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Leães CG, Meurer RT, Coutinho LB, Ferreira NP, Pereira-Lima JF, da Costa Oliveira M: Immunohistochemical expression of aromatase and estrogen, androgen and progesterone receptors in normal and neoplastic human meningeal cells. Neuropathology; 2010 Feb 1;30(1):44-9
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  • [Title] Immunohistochemical expression of aromatase and estrogen, androgen and progesterone receptors in normal and neoplastic human meningeal cells.
  • Evidence suggests that sex hormones may play a role in the tumorigenesis of meningiomas, and studies have demonstrated the expression of hormone receptors in these tumors.
  • Aromatase expression has been detected in several normal tissues, including neurons in the CNS, and tumor tissues.
  • We aim to assess the expression of aromatase (ARO) and of progesterone receptor (PR), estrogen receptor (ER) and androgen receptor (AR) in both normal and neoplastic meningeal cells.
  • Control sections of normal meningeal cells, 19 patients, were obtained by evaluating the arachnoid tissue present in the arachnoid cyst resected material.
  • Behavior pattern differences observed between aromatase expression, present in normal tissues and absent in meningiomas, and estrogen and androgen hormone receptors, absent in normal tissues and present in meningiomas, suggest that there is heterogeneity in modulation by sex steroids in the development of these tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Arachnoid Cysts / enzymology. Arachnoid Cysts / metabolism. Brazil. Cross-Sectional Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Odds Ratio. Sex Characteristics. Young Adult

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  • (PMID = 19703265.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; EC 1.14.14.1 / Aromatase
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21. Granados-García M, Celis-López MA, Aguilar-Ponce JL, Villavicencio-Valencia V, Luna-Ortiz K, Poitevin-Chachón A, Carrillo-Hernández F, Herrera-Gómez A: Craniofacial resection for sinunasal tumors. Clin Transl Oncol; 2006 Feb;8(2):119-23
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  • [Title] Craniofacial resection for sinunasal tumors.
  • INTRODUCTION: Malignant sinonasal tumors are very rare in Mexico.
  • OBJECTIVE: We undertook a retrospective analysis in order to evaluate results of craniofacial resections for sinonasal tumors.
  • In 13 patients tumor was limited to maxillo-ethmoid complex, but in 6 cases tumor involved anteroinferior aspect of sphenoid sinus, in 7 extended to the orbit, in 3 to dura and two to the brain.
  • CONCLUSIONS: Craniofacial resection is a safe and valuable tool in the treatment of advanced sinonasal tumors involving cranial base.
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Neoplasms / secondary. Brain Neoplasms / surgery. Combined Modality Therapy. Dura Mater / surgery. Ethmoid Sinus / surgery. Female. Humans. Male. Maxillary Sinus Neoplasms / surgery. Meningeal Neoplasms / secondary. Meningeal Neoplasms / surgery. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Orbital Neoplasms / secondary. Orbital Neoplasms / surgery. Radiotherapy, Adjuvant. Retrospective Studies. Salvage Therapy. Sphenoid Sinus / surgery. Survival Analysis. Survival Rate. Treatment Outcome

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  • (PMID = 16632426.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Italy
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22. Fountas KN, Kapsalaki E, Kassam M, Feltes CH, Dimopoulos VG, Robinson JS, Smith JR: Management of intracranial meningeal hemangiopericytomas: outcome and experience. Neurosurg Rev; 2006 Apr;29(2):145-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of intracranial meningeal hemangiopericytomas: outcome and experience.
  • Hemangiopericytomas represent rare intracranial tumors that have a tendency to recur locally and have the unique characteristic of giving extracranial metastases.
  • Their neuroimaging preoperative evaluation included plain skull X-rays, head CT scans, brain MRI, angiograms, and (1)HMRS.
  • Preoperative embolization of the tumor was employed in 6/11 patients.
  • All patients underwent craniotomy for tumor resection and postoperative radiation treatment was employed on all but one.
  • [MeSH-major] Hemangiopericytoma / surgery. Meningeal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Diagnostic Imaging. Female. Follow-Up Studies. Glasgow Outcome Scale. Humans. Image Processing, Computer-Assisted. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Magnetic Resonance Spectroscopy. Male. Meninges / pathology. Meninges / surgery. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Postoperative Complications / diagnosis

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  • (PMID = 16391940.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Kang SG, Yoo DS, Cho KS, Kim DS, Chang ED, Huh PW, Kim MC: Coexisting intracranial meningeal melanocytoma, dermoid tumor, and Dandy-Walker cyst in a patient with neurocutaneous melanosis. Case report. J Neurosurg; 2006 Mar;104(3):444-7
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  • [Title] Coexisting intracranial meningeal melanocytoma, dermoid tumor, and Dandy-Walker cyst in a patient with neurocutaneous melanosis. Case report.
  • Primary intracranial melanocytic and dermoid tumors are also benign congenital lesions that usually arise from the leptomeninges and are formed by the inclusion of cutaneous ectoderm at the time of neural tube closure.
  • The authors describe a patient with coexisting intracranial meningeal melanocytoma, NCM with Dandy-Walker malformation, and intraventricular dermoid tumor.
  • [MeSH-major] Dandy-Walker Syndrome / complications. Dermoid Cyst / pathology. Melanoma / pathology. Melanosis / complications. Meningeal Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Comorbidity. Humans. Male

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  • (PMID = 16572661.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Zierski J, Veelken J: [Tumors of the craniocervical junction]. Orthopade; 2006 Mar;35(3):288-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors of the craniocervical junction].
  • In this review, the authors describe the most common tumors of the craniocervical junction and their management.
  • [MeSH-minor] Adolescent. Adult. Biopsy. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Middle Aged. Spinal Cord / pathology. Time Factors. Tomography, Spiral Computed. Tomography, X-Ray Computed

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  • (PMID = 16477403.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopäde
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 9
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25. Budrukkar A, Jalali R, Dutta D, Sarin R, Devlekar R, Parab S, Kakde A: Prospective assessment of quality of life in adult patients with primary brain tumors in routine neurooncology practice. J Neurooncol; 2009 Dec;95(3):413-419
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  • [Title] Prospective assessment of quality of life in adult patients with primary brain tumors in routine neurooncology practice.
  • The aim of this article is to evaluate and assess the impact of various factors on quality of life (QOL) in adult patients with primary brain tumors seen consecutively in routine neurooncology practice.
  • Two hundred and fifty-seven adult patients, after undergoing surgical intervention and histologically proven primary brain neoplasms were registered in the NeuroOncology Clinic at our centre during 1 full calendar year.
  • The study included detailed neurological assessment, evaluation of QOL using EORTC questionnaire (QLQ-30) and specific Brain Cancer module (BN 20).
  • In the present analysis, QOL scores before starting adjuvant treatment were measured and impact of patient and tumor related factors were analyzed.
  • Baseline global QOL data of all patients (available in 243) was relatively low including in all histological tumor types.
  • Patients with lower performance status (KPS < 70) had a lower global QOL (KPS >or= 80 vs. <or= 70; 37 vs. 67; p = 0.001) including in all histological types of high-grade gliomas (HGG) (p = 0.005), low-grade gliomas (LGG) (p = 0.04) and benign tumors (p = <0.001).
  • Tumor type is an important patient related factor that influences baseline global scores (LGG vs. HGG 62 and 52; p = 0.015).
  • Type of surgery (biopsy/complete excision) (p = 0.284) and site of tumor (p = 0.309) did not show any impact on QOL score.
  • Patients with primary brain tumours before starting adjuvant therapy have relatively low baseline quality of life scores, especially in lower economic and literacy strata.
  • Patients with malignant tumors and poor performance status had significantly lower QOL scores even before starting adjuvant treatment.
  • [MeSH-major] Brain Neoplasms / physiopathology. Brain Neoplasms / therapy. Glioma / physiopathology. Glioma / therapy. Outpatient Clinics, Hospital. Quality of Life
  • [MeSH-minor] Adenoma / physiopathology. Adenoma / therapy. Adolescent. Adult. Educational Status. Female. Health Status. Humans. India. Karnofsky Performance Status. Male. Meningeal Neoplasms / physiopathology. Meningeal Neoplasms / therapy. Middle Aged. Pituitary Neoplasms / physiopathology. Pituitary Neoplasms / therapy. Prospective Studies. Surveys and Questionnaires. Young Adult

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  • (PMID = 19548070.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Shin H, Barrenechea IJ, Lesser J, Sen C, Perin NI: Occipitocervical fusion after resection of craniovertebral junction tumors. J Neurosurg Spine; 2006 Feb;4(2):137-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occipitocervical fusion after resection of craniovertebral junction tumors.
  • OBJECT: Surgical access to tumors at the craniovertebral junction (CVJ) requires extensive bone removal.
  • Guidelines for the use of occipitocervical fusion (OCF) after resection of CVJ tumors have been based on anecdotal evidence.
  • The authors performed a retrospective study of factors associated with the use of OCF in 46 patients with CVJ tumors.
  • METHODS: The authors retrospectively reviewed the cases of 51 patients with CVJ tumors treated by their group between March 1991 and February 2004.
  • Of the 46 patients, 16 had foramen magnum meningiomas, 17 had chordomas, one had a chondrosarcoma, two had Schwann cell tumors, two had glomus tumors, and eight had other types of tumors.
  • Patients with chordomas and metastatic tumors were most likely to require OCF.
  • [MeSH-major] Chordoma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Skull Base Neoplasms / surgery. Spinal Fusion / methods. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Biomechanical Phenomena. Cervical Vertebrae / pathology. Cervical Vertebrae / surgery. Child. Female. Humans. Male. Middle Aged. Neck Pain. Neoplasm Metastasis. Occipital Bone / pathology. Occipital Bone / surgery. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 16506481.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Leonetti JP, Anderson DE, Marzo SJ, Origitano TC, Schuman R: The preauricular subtemporal approach for transcranial petrous apex tumors. Otol Neurotol; 2008 Apr;29(3):380-3
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  • [Title] The preauricular subtemporal approach for transcranial petrous apex tumors.
  • OBJECTIVE: To review our series of 51 patients with transcranial petrous apex tumors who were surgically managed through a preauricular subtemporal approach.
  • PATIENTS: All patients with transcranial petrous apex tumors who were surgically treated between July 1988 and July 2005 with a preauricular subtemporal approach.
  • MAIN OUTCOME MEASURES: The degree of tumor resection and long-term results.
  • RESULTS: Total tumor resection was achieved in 45 patients, and tumor was left in the cavernous sinus in 6 cases.
  • Magnetic resonance imaging surveillance revealed no recurrent tumor in 36 patients, stable residual disease in 5 cases, and regrowth of tumor in 10 individuals (mean follow-up, 8.8 yr).
  • The preauricular subtemporal approach allows wide access for transcranial petrous apex tumors with preservation of hearing.
  • Tumor control using this approach was achieved in 41 (80%) of 51 of the patients in this series.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma / surgery. Neurosurgical Procedures / methods. Petrous Bone / surgery
  • [MeSH-minor] Adult. Aged. Chondrosarcoma / pathology. Chondrosarcoma / surgery. Chordoma / pathology. Chordoma / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Osteoblastoma / pathology. Osteoblastoma / surgery. Postoperative Complications. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / surgery

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  • (PMID = 18223509.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Miyatake S, Kajimoto Y, Kuroiwa T: [Intraoperative photo-dynamic diagnosis of brain tumors]. Brain Nerve; 2009 Jul;61(7):835-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intraoperative photo-dynamic diagnosis of brain tumors].
  • As PpIX preferentially accumulates in the tumor tissue in comparison with normal tissue, this red fluorescence becomes a good hallmark for discrimination between normal and tumor tissues, especially in malignant gliomas, which have infiltrative characteristics.
  • Approximately 80% to 90% of the malignant gliomas show this red fluorescence in surgery as mentioned above, while only a limited number of metastatic brain tumor cases do.
  • In the surgery for metastatic brain tumor and lesionectomy for radiation necrosis and neurodegenerative disease, white matter around the lesion showed vague fluorescence, which also provided us with a hallmark in the surgery.
  • Additionally, in meningioma, some tumors showed the red fluorescence, which is especially helpful in the removal of the infiltrative portion in the bone and normal parenchyma.
  • [MeSH-major] Aminolevulinic Acid. Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Glioma / diagnosis. Glioma / surgery
  • [MeSH-minor] Adult. Aged. Female. Fluorescence. Humans. Intraoperative Period. Meningeal Neoplasms / surgery. Meningioma / surgery. Microsurgery. Neurosurgical Procedures. Protoporphyrins. Surgery, Computer-Assisted. Ultraviolet Rays

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  • (PMID = 19618861.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Protoporphyrins; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
  • [Number-of-references] 17
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29. Aui-aree N, Phruanchroen C, Oearsakul T, Hirunpat S, Sangthong R: Three years experience of suprasellar tumors in neuro-ophthalmology clinic. J Med Assoc Thai; 2010 Jul;93(7):818-23
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  • [Title] Three years experience of suprasellar tumors in neuro-ophthalmology clinic.
  • OBJECTIVE: To examine pre-treatment ophthalmic presentations and treatment results and to identify factors that may influence improved visual outcomes in patients with suprasellar tumor MATERIAL AND METHOD: The medical records of patients with suprasellar tumors who were diagnosed between July 2005 and June 2008 in the neuro-ophthalmology clinic of Songklanagarind Hospital were retrospectively reviewed by two ophthalmologists.
  • The most common tumor was pituitary adenoma (macroadenoma and prolactinoma).
  • Visual improvement was achieved in pituitary adenoma in 20 of 25 eyes (80%), meningioma in 8 of 12 eyes (67%) and other tumors in 2 of 5 eyes (40%).
  • CONCLUSION: The most common presentation of suprasellar tumor was blurred vision.
  • [MeSH-major] Adenoma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Pituitary Neoplasms / surgery. Vision Disorders / etiology. Visual Acuity
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Recovery of Function. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20649062.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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30. Dusick JR, Esposito F, Kelly DF, Cohan P, DeSalles A, Becker DP, Martin NA: The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors. J Neurosurg; 2005 May;102(5):832-41
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  • [Title] The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors.
  • OBJECT: The extended transsphenoidal approach, which requires a bone and dural opening through the tuberculum sellae and posterior planum sphenoidale, is increasingly used for the treatment of nonadenomatous suprasellar tumors.
  • The authors present their experiences in using the direct endonasal approach in patients with nonadenomatous suprasellar tumors.
  • Twenty-six procedures for tumor removal were performed in 24 patients (ages 9-79 years), including two repeated operations for residual tumor.
  • Of 13 patients with tumor-related visual loss, 85% improved postoperatively.
  • CONCLUSIONS: The direct endonasal skull-base approach provides an effective minimally invasive means for resecting or debulking nonadenomatous suprasellar tumors that have traditionally been approached through a sublabial or transcranial route.
  • [MeSH-major] Brain Neoplasms / surgery. Minimally Invasive Surgical Procedures / methods. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Diseases / surgery. Central Nervous System Cysts / surgery. Child. Craniopharyngioma / surgery. Epidermal Cyst / surgery. Humans. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Pituitary Neoplasms / surgery. Postoperative Complications. Sphenoid Bone. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2005 May;102(5):825-7; discussion 827-8 [15926704.001]
  • (PMID = 15926706.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Poltermann S, Schlehofer B, Steindorf K, Schnitzler P, Geletneky K, Schlehofer JR: Lack of association of herpesviruses with brain tumors. J Neurovirol; 2006 Apr;12(2):90-9
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  • [Title] Lack of association of herpesviruses with brain tumors.
  • Gliomas are the most frequent primary brain tumors in humans.
  • Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported to be present in all of 27 glioma samples investigated in contrast to other brain tissues, and it was hypothesized that HCMV might play a role in glioma pathogenesis.
  • Additionally, corresponding blood samples from 72 patients were analyzed for the presence of HCMV DNA to check for a possible contamination of tumor tissues with HCMV-infected blood cells.
  • No HCMV DNA sequences were found, neither in brain tumor tissues nor in corresponding blood samples.
  • Serological analyses of brain tumor patients showed no significant differences in the prevalences of antibodies to HCMV, HSV, EBV, or VZV compared to the general population.
  • Thus, the data of the present study do not support the hypothesis of an association of herpesviruses with the development of primary brain tumors.
  • [MeSH-major] Brain Neoplasms / virology. Cytomegalovirus / isolation & purification. Glioma / virology. Meningeal Neoplasms / virology. Meningioma / virology. Neuroma, Acoustic / virology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Cytomegalovirus Infections / complications. DNA, Viral / blood. DNA, Viral / genetics. Female. Herpesvirus 3, Human / immunology. Herpesvirus 4, Human / immunology. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Simplexvirus / immunology

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  • [CommentIn] J Neurovirol. 2007;13(1):85; author reply 86-7 [17454453.001]
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  • (PMID = 16798670.001).
  • [ISSN] 1355-0284
  • [Journal-full-title] Journal of neurovirology
  • [ISO-abbreviation] J. Neurovirol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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32. Waki F, Ando M, Takashima A, Yonemori K, Nokihara H, Miyake M, Tateishi U, Tsuta K, Shimada Y, Fujiwara Y, Tamura T: Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors. J Neurooncol; 2009 Jun;93(2):205-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors.
  • BACKGROUND: Leptomeningeal metastasis (LM) occurs in 4-15% of patients with solid tumors.
  • The purpose of this study was to identify the prognostic factors in patients with solid tumors with cytologically proven LM.
  • Forty-nine patients had brain metastasis at the time of diagnosis of the LM, and in 51 patients, MRI revealed meningeal dissemination in the brain or spine.
  • [MeSH-major] Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / secondary. Neoplasm Metastasis / pathology. Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brain Neoplasms / mortality. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Breast Neoplasms / mortality. Breast Neoplasms / pathology. Female. Humans. Lung Neoplasms / mortality. Lung Neoplasms / pathology. Male. Middle Aged. Prognosis. Retrospective Studies. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / secondary. Stomach Neoplasms / mortality. Stomach Neoplasms / pathology. Survival Analysis. Time Factors. Young Adult

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  • (PMID = 19043775.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Finn MA, Blumenthal DT, Salzman KL, Jensen RL: Transient postictal MRI changes in patients with brain tumors may mimic disease progression. Surg Neurol; 2007 Mar;67(3):246-50; discussion 250
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient postictal MRI changes in patients with brain tumors may mimic disease progression.
  • BACKGROUND: Transient postictal imaging abnormalities in patients with non-tumor-related seizures are well documented and include fluid-attenuated inversion recovery/T2 hyperintensity and parenchymal and meningeal contrast enhancement.
  • In contrast, transient postictal imaging abnormalities in patients with tumor-related seizures have been poorly described.
  • Fifty percent of patients with brain tumors have a seizure during the course of their illness and are often imaged after a seizure or after a change in seizure character or frequency.
  • METHODS: We describe 3 patients with brain tumors and transient postictal MRI changes that mimicked disease progression and infection.
  • These changes were suspicious for tumor progression in 2 cases and for recurrent infection in the third.
  • CONCLUSIONS: Imaging shortly after an ictal event can potentially mislead the clinician to interpret changes as tumor or pathologic progression.
  • We recommend repeat imaging be performed in patients with brain tumors and seizures several weeks after seizure control if clinically feasible.
  • [MeSH-major] Astrocytoma / complications. Astrocytoma / pathology. Brain Neoplasms / complications. Brain Neoplasms / pathology. Glioma / complications. Glioma / pathology. Magnetic Resonance Imaging. Meningeal Neoplasms / complications. Meningeal Neoplasms / pathology. Meningioma / complications. Meningioma / pathology. Seizures / diagnosis. Seizures / etiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Humans. Male. Middle Aged. Severity of Illness Index. Time Factors. Treatment Outcome

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  • (PMID = 17320628.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Qu M, Wang YJ, Wu AH, Wang YB: [Analysis of surgical treatment strategies of petroclival region tumors]. Zhonghua Wai Ke Za Zhi; 2010 Aug 15;48(16):1225-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of surgical treatment strategies of petroclival region tumors].
  • OBJECTIVE: To explore the surgical strategy of the tumors of petroclival region.
  • METHODS: The surgical data of 55 cases presented with meningioma and trigeminal nerve sheath tumors from January 2002 to February 2009 was retrospectively analyzed.
  • CONCLUSIONS: The pursuit of full-cut for the tumors of petroclival region may result in serious neurological dysfunction and poor life quality after the operation.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neurilemmoma / surgery. Trigeminal Nerve
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 21055211.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. Liu AL, Wang C, Sun S, Wang M, Liu P: Gamma knife radiosurgery for tumors involving the cavernous sinus. Stereotact Funct Neurosurg; 2005;83(1):45-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for tumors involving the cavernous sinus.
  • OBJECTIVE: To study the features of diagnosis and radiosurgery of tumors involving the cavernous sinus.
  • Our experience of treating cavernous sinus tumors by GK was analyzed retrospectively.
  • RESULTS: A Hundred and forty-four (82.3%) patients were followed from 1 to 84 months (median 32.5 months); total tumor control rate was 94%.
  • Surgery was performed after radiosurgery in 3 patients because of tumor enlargement.
  • Metastatic tumor in the cavernous sinus was highly sensitive to irradiation.
  • CONCLUSION: With high tumor control rate and few complications, GK surgery could become a main option for small benign or residual tumors involving the cavernous sinus.
  • It is also very useful as part of comprehensive therapy for metastatic tumors in the cavernous sinus.
  • [MeSH-major] Brain Neoplasms / surgery. Cavernous Sinus / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma / surgery. Radiosurgery
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adolescent. Adult. Aged. Child. Chordoma / pathology. Chordoma / surgery. Female. Follow-Up Studies. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery. Reoperation. Retrospective Studies

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  • (PMID = 15860936.001).
  • [ISSN] 1011-6125
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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36. Gammon DC, Bhatt MS, Tran L, Van Horn A, Benvenuti M, Glantz MJ: Intrathecal topotecan in adult patients with neoplastic meningitis. Am J Health Syst Pharm; 2006 Nov 1;63(21):2083-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrathecal topotecan in adult patients with neoplastic meningitis.
  • Of the 11 patients with primary CNS tumors, 6 patients achieved CSF clearing after the first dose of intrathecal topotecan, 2 patients after the second dose, and 1 patient after the fifth dose.
  • For the 3 patients with secondary CSF tumors, 1 patient achieved CSF clearing after the third dose and 2 patients did not reach the primary endpoint.
  • CONCLUSION: Intrathecal topotecan appeared to be effective and safe in adult patients with NM.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Injections, Spinal. Meningeal Neoplasms / drug therapy. Topotecan / therapeutic use

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  • (PMID = 17057045.001).
  • [ISSN] 1079-2082
  • [Journal-full-title] American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • [ISO-abbreviation] Am J Health Syst Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 7M7YKX2N15 / Topotecan
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37. Maranhão ET, Maranhão-Filho P, Lima MA, Vincent MB: Can clinical tests detect early signs of monohemispheric brain tumors? J Neurol Phys Ther; 2010 Sep;34(3):145-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can clinical tests detect early signs of monohemispheric brain tumors?
  • Despite the availability of sophisticated neuroimaging methods, to identify intracranial tumors the clinical recognition of associated subtle motor deficits is important for practice.
  • Precise clinical tests are particularly advantageous, as some tumors may remain unnoticed for many.
  • The purpose of this study was to determine the sensitivity and specificity of 13 clinical tests for detection of subtle motor deficits in patients with unilateral brain tumors.
  • METHODS: Sixty patients with unilateral brain tumors without obvious focal signs and 30 controls with normal magnetic resonance imaging were examined.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Glioblastoma / diagnosis. Neurologic Examination / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Early Diagnosis. Ependymoma / diagnosis. Female. Functional Laterality. Humans. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Middle Aged. Neurocytoma / diagnosis. Predictive Value of Tests. Sensitivity and Specificity. Young Adult

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  • (PMID = 20799429.001).
  • [ISSN] 1557-0584
  • [Journal-full-title] Journal of neurologic physical therapy : JNPT
  • [ISO-abbreviation] J Neurol Phys Ther
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / / ; United Kingdom / Wellcome Trust / /
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Kríz L, Bicíková M, Mohapl M, Hill M, Cerný I, Hampl R: Steroid sulfatase and sulfuryl transferase activities in human brain tumors. J Steroid Biochem Mol Biol; 2008 Mar;109(1-2):31-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Steroid sulfatase and sulfuryl transferase activities in human brain tumors.
  • Neuroactive steroids (dehydroepiandrosterone, pregnenolone) and their sulfates act as modulators of glutamate and gamma-aminobutyrate type A receptors in the brain The physiological ratio of these neuromodulators is maintained by two enzymes present in the brain, namely, steroid sulfatase (STS) and steroid sulfuryl transferase (SULT).
  • Following previous determination of their activities in monkey brains, their activities were evaluated in human brain tumors.
  • Both enzyme activities were measured in the 55 most frequent human brain tumors (glioblastomas, pituitary adenomas, meningiomas, astrocytomas).
  • Significant differences were found in STS activity among investigated types of tumors except the pair of pituitary adenomas-glioblastomas, while significant differences were found in SULT activity among investigated types of tumors.
  • [MeSH-major] Brain Neoplasms / enzymology. Steryl-Sulfatase / metabolism. Sulfotransferases / metabolism
  • [MeSH-minor] Adenoma / enzymology. Adult. Astrocytoma / enzymology. Female. Gas Chromatography-Mass Spectrometry. Glioblastoma / enzymology. Humans. Male. Meningeal Neoplasms / enzymology. Meningioma / enzymology. Middle Aged. Pituitary Neoplasms / enzymology. Radioimmunoassay

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  • (PMID = 18249534.001).
  • [ISSN] 0960-0760
  • [Journal-full-title] The Journal of steroid biochemistry and molecular biology
  • [ISO-abbreviation] J. Steroid Biochem. Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.8.2.- / Sulfotransferases; EC 2.8.2.15 / steroid sulfotransferase; EC 3.1.6.2 / Steryl-Sulfatase
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39. Miyatake S, Tamura Y, Kawabata S, Iida K, Kuroiwa T, Ono K: Boron neutron capture therapy for malignant tumors related to meningiomas. Neurosurgery; 2007 Jul;61(1):82-90; discussion 90-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Boron neutron capture therapy for malignant tumors related to meningiomas.
  • OBJECTIVE: Malignant meningiomas, similar to glioblastomas, are difficult tumors to control.
  • We tried to control malignant tumors related to meningiomas by boron neutron capture therapy (BNCT).
  • METHODS: Since June 2005, we applied BNCT with 13 rounds of neutron irradiation to seven cases of malignant tumors related to meningiomas.
  • RESULTS: Five of the six patients who underwent BPA-PET analysis showed good BPA uptake, with a greater than 2.7 tumor-to-healthy brain ratio.
  • The atypical meningioma case showed a tumor-to-healthy brain ratio of 2.0.
  • The original tumor sizes were between 13.6 and 109 ml.
  • [MeSH-major] Boron Neutron Capture Therapy / methods. Brain Neoplasms / radionuclide imaging. Brain Neoplasms / radiotherapy. Meningeal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Brain Injuries / etiology. Brain Injuries / radionuclide imaging. Female. Humans. Male. Radiation Injuries / etiology. Radiation Injuries / radionuclide imaging. Treatment Outcome

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  • (PMID = 17621022.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Kabil MS, Shahinian HK: Application of the supraorbital endoscopic approach to tumors of the anterior cranial base. J Craniofac Surg; 2005 Nov;16(6):1070-4; discussion 1075
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Application of the supraorbital endoscopic approach to tumors of the anterior cranial base.
  • Access to tumors of the anterior cranial fossa traditionally has required wide exposure of the surgical field, along with prolonged retraction of the frontal lobes or potentially disfiguring transfacial approaches.
  • With the introduction of progressively less-invasive approaches, intracranial tumors with craniofacial involvement have become amenable to en bloc resection with a minimum of deleterious consequences.
  • The use of endoscopy allowed thorough visualization of all critical structures at the paramedian skull base without the need for a bicoronal scalp flap, bifrontal osteotomies, or brain retraction.
  • [MeSH-minor] Adenoma / surgery. Adult. Aged. Arachnoid Cysts / surgery. Craniopharyngioma / surgery. Electrocoagulation. Female. Follow-Up Studies. Frontal Sinus / surgery. Humans. Male. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Minimally Invasive Surgical Procedures. Mucocele / surgery. Paranasal Sinus Diseases / surgery. Pituitary Neoplasms / surgery. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • (PMID = 16327556.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Lan Q, Qian ZY, Chen J, Liu SH, Lu ZH, Huang Q: [Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches]. Zhonghua Yi Xue Za Zhi; 2005 Jan 26;85(4):219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches].
  • OBJECTIVE: To explore the surgical outcome and skills of keyhole approaches to posterior cranial fossa tumors.
  • METHODS: A retrospective analysis of the clinical data of 43 consecutive patients with posterior cranial fossa tumors, including acoustic neurinoma, petroclival meningioma, pons tumor, fourth ventricular tumor, etc. was conducted.
  • Subtemporal, retromastoid, or middle suboccipital keyhole approach was chosen respectively according to the anatomic positions of those different tumors.
  • RESULTS: The tumors were totally removed in 37 of the 43 patients (86.0%), subtotally removed in 5 (11.6%) and mostly removed in 1 (2.3%).
  • All of the 18 acoustic neurinomas (100%) were totally removed and the facial nerves of 15 patients (83.3%) were preserved anatomically, however, one patient died of brain stem edema on the 2nd postoperative day.
  • Among the 6 pons tumors 3 were removed totally and 3 subtotally.
  • All the other tumors were resected completely without neurological dysfunction observed, however, one patient with a cholesteatoma failed to demonstrate apparent improvement in his diplopia.
  • CONCLUSION: Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches, with safe, succinct and minimally invasive property, is one of the promising directions in modern neurosurgery.
  • [MeSH-major] Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cranial Fossa, Posterior / surgery. Female. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Pons. Retrospective Studies. Treatment Outcome

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  • (PMID = 15854477.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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42. Fuller CE, Perry A: Molecular diagnostics in central nervous system tumors. Adv Anat Pathol; 2005 Jul;12(4):180-94
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  • [Title] Molecular diagnostics in central nervous system tumors.
  • In this regard, the field is primed by recent advances in basic research, elucidating the molecular mechanisms of tumorigenesis and progression in the most common adult and pediatric brain tumors.
  • Thus far, few have made the transition into routine clinical practice, the most notable example being 1p and 19q testing in oligodendroglial tumors.
  • The goal of this article is to highlight the most common genetic alterations currently implicated in CNS tumors, focusing most on those that are either already in common use in ancillary molecular diagnostics testing or are likely to become so in the near future.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Central Nervous System Neoplasms / genetics. Ependymoma / genetics. Oligodendroglioma / genetics
  • [MeSH-minor] Animals. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Chromosome Aberrations. Humans. In Situ Hybridization, Fluorescence. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / genetics. Meningioma / diagnosis. Meningioma / genetics. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / genetics. Polymerase Chain Reaction. Prognosis

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  • (PMID = 16096380.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 260
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43. Kabil MS, Shahinian HK: The endoscopic supraorbital approach to tumors of the middle cranial base. Surg Neurol; 2006 Oct;66(4):396-401; discussion 401
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  • [Title] The endoscopic supraorbital approach to tumors of the middle cranial base.
  • BACKGROUND: Access to tumors of the middle cranial base has traditionally required wide surgical exposures via open craniotomies.
  • These open techniques often require the use of potentially disfiguring skin incisions and are often associated with a significant degree of brain retraction and potential morbidity.
  • We report our experience with the use of a minimally invasive supraorbital endoscopic approach through the eyebrow for excision of middle cranial base tumors in 2 cases.
  • METHODS: We describe 2 patients with large-sized middle cranial fossa tumors (a medial sphenoid wing meningioma measuring 6 x 4 cm and a recurrent right cavernous sinus meningioma measuring 4 x 3.5 cm) that were entirely removed via a fully endoscopic supraorbital approach using a 1.5-cm keyhole craniotomy.
  • [MeSH-major] Cranial Fossa, Middle / surgery. Craniotomy / methods. Endoscopy / methods. Frontal Bone / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Cavernous Sinus Thrombosis / etiology. Cavernous Sinus Thrombosis / physiopathology. Cavernous Sinus Thrombosis / surgery. Dura Mater / pathology. Dura Mater / surgery. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / physiopathology. Neoplasm Recurrence, Local / surgery. Orbit / anatomy & histology. Orbit / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Sphenoid Bone / pathology. Sphenoid Bone / surgery. Treatment Outcome

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  • (PMID = 17015120.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Xu D, Liu D, Zhang Z, Zhang Y, Li Y, Liu X, Jia Q, Zheng L, Song G: Gamma Knife surgery in the management of orbital tumors. J Neurosurg; 2010 Dec;113 Suppl:34-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma Knife surgery in the management of orbital tumors.
  • OBJECT: The authors evaluated the results they obtained using Gamma Knife surgery (GKS) in patients with orbital tumors.
  • METHODS: This is a retrospective clinical evaluation of 202 patients with orbital tumors who were treated with GKS between September 1995 and October 2008.
  • There were 84 meningiomas, 38 epithelial tumors of the lacrimal gland, 23 schwannomas, 18 malignant choroidal melanomas, 12 optic nerve gliomas, 11 orbital metastases, 10 pseudotumors of the orbit, 3 retinoblastomas, and 3 cases of fibromatosis.
  • The tumor margin dose ranged from 10 to 40 Gy.
  • RESULTS: At a median follow-up period of 34.5 ± 14.7 months (range 12-114 months), tumor shrinkage was observed in 118 patients (58.4%) and stable tumor size in 71 patients (35.1%).
  • Regularly scheduled neuroimaging studies demonstrated evidence of tumor progression in only 13 patients (6.4%): 9 of these patients underwent repeated GKS and 4 received surgical treatment.
  • CONCLUSIONS: Gamma Knife surgery provides an effective management strategy in patients with orbital tumors; it achieves excellent preservation of neurological function and is associated with few treatment-related complications.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Male. Meningeal Neoplasms / surgery. Middle Aged. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 21121785.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Liang YM, Li XH, Lü YL, Zhong M: [Morphology and immunohistochemical characteristics of hepatic primary and metastatic malignant spindle cell tumors]. Zhonghua Yi Xue Za Zhi; 2005 Jan 12;85(2):96-100
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  • [Title] [Morphology and immunohistochemical characteristics of hepatic primary and metastatic malignant spindle cell tumors].
  • OBJECTIVE: To investigate the morphology and immunohistochemical characteristics of hepatic primary and metastatic malignant spindle cell tumors, and to conclude the diagnostic and differential diagnostic criteria for these morphologically similar tumors.
  • METHODS: Forty-six specimens of hepatic spindle cell tumors.
  • 20 primary tumors (43.4%), including 3 cases of sarcomatoid carcinoma (6.5%), 11 of angiosarcoma (23.9%), 2 of epithelioid hemangioendothelioma (5%), 1 of spindle cell carcinoid (2.2%), and 3 of undifferentiated sarcoma (6.5%).
  • and 26 metastatic malignant tumors (56.5%), including 20 cases of gastrointestinal stromal tumors (GIST, 43.4%), 3 of leiomyosarcoma (6.5%), 2 of malignant peripheral never sheath tumor (4.3%), and 1 of meningeal hemangiopericytoma (2.2%), resected during operation or collected during imaging-mediated liver puncture underwent hematoxylin-eosin staining, SP staining, and EnVision immunohistochemical staining.
  • RESULTS: Either primary or metastatic tumors showed extensive overlapping in histopathologic appearance, and hemangiopericytoma-like structure was the predominant pattern, which could be seen in nearly every kind of hepatic spindle cell tumors.
  • Most stromal tumor cases were CD117 positive, and existed the condition that the primary tumor was positive and the metastatic tumor was negative or vice versa or one part of specimen was positive but other part was negative.
  • Leiomyosarcoma was immunoreactive to smooth muscle specific antigen (SMA), malignant peripheral nerve sheath tumor was immunoreactive to S-100 protein and neurofilament (NF), and both were CD117 negative.
  • CONCLUSION: Primary angiosarcoma is the most common form of primary spindle cell tumor in liver, and metastatic GIST is predominant in hepatic metastatic spindle cell tumors.
  • A penal of immunohistochemical markers is necessary for the final diagnosis of these tumors because of the complexity and similarity of different tumors of this kind.
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD31 / biosynthesis. Antigens, CD34 / biosynthesis. Biomarkers, Tumor. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15774214.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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46. Muto J, Kawase T, Yoshida K: Meckel's cave tumors: relation to the meninges and minimally invasive approaches for surgery: anatomic and clinical studies. Neurosurgery; 2010 Sep;67(3 Suppl Operative):ons291-8; discussion ons298-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meckel's cave tumors: relation to the meninges and minimally invasive approaches for surgery: anatomic and clinical studies.
  • BACKGROUND: Literature on tumors originating from Meckel's cave (MC) and their surgical treatment are scarce.
  • OBJECTIVE: We present 37 cases of tumors originating from MC, the largest single-institution series reported thus far, and discuss the ideal surgical methods for each tumor type in relation to the normal and pathological anatomy of MC.
  • METHODS: We studied 37 cases of surgery for tumors in MC (26 schwannomas, 7 meningiomas, 2 epidermoids, 1 hemangiopericytoma, and 1 dermoid) performed at our institution between 1986 and 2008.
  • We excluded cases of large tumors of unknown origin, especially meningiomas.
  • Surgery for tumors in MC was performed via 2 approaches: anterolateral interdural access (Dolenc's) approach and posterior access via the anterior petrosal approach (APA).
  • RESULTS: The Dolenc approach was useful for parasellar tumors, especially schwannomas, because it resulted in minimal damage to the temporal lobe and adjacent cranial nerves.
  • The APA was useful for dumbbell-shaped tumors extending into the posterior fossa.
  • Tumors of nonmeningeal origin (schwannomas, epidermoids, and dermoids) were safely resected, with no postoperative complications except facial hypesthesia.
  • CONCLUSION: An understanding of meningeal structure around MC enhances the radicality of tumor resection and helps minimize damage to adjacent structures.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neurilemmoma / surgery. Neurosurgical Procedures / methods. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Trigeminal Nerve / pathology. Trigeminal Nerve / surgery. Young Adult

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  • (PMID = 20679921.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Demirci H, Marentette LJ, Nelson CC: The transglabellar/subcranial approach for surgical excision of periocular second tumors in retinoblastoma. Orbit; 2008;27(4):285-91
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  • [Title] The transglabellar/subcranial approach for surgical excision of periocular second tumors in retinoblastoma.
  • PURPOSE: To evaluate the use of transglabellar/subcranial approach for surgical resection of periocular second non-ocular tumors in retinoblastoma patients.
  • METHODS: Seven retinoblastoma patients with periocular second tumor involving anterior skull base underwent surgical resection by transglabellar/subcranial approach in a single center.
  • RESULTS: The most common presenting symptom in retinoblastoma patients with periocular second tumor was difficulty in maintaining the prosthesis in three patients (43%), followed by epistaxis in one (14%), palpable orbital mass in one (14%), persistent periocular swelling in one (14%), and visual loss in one (14%) patient.
  • Periocular second tumors were leiomyosarcoma in three (43%) patients, osteosarcoma in three (43%), and sphenoid wing meningioma in one (14%) patient.
  • CONCLUSIONS: Retinoblastoma patients with periocular second tumors have a poor prognosis.
  • The transglabellar/subcranial approach can be used for surgical resection of periocular second tumor involving skull base with low morbidity.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Eye Enucleation. Eyebrows. Female. Frontal Bone. Humans. Leiomyosarcoma / surgery. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Orbital Neoplasms / surgery. Osteosarcoma / surgery. Paranasal Sinus Neoplasms / surgery. Radiotherapy. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 18716966.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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48. Nakaya K, Niranjan A, Kondziolka D, Kano H, Khan AA, Nettel B, Koebbe C, Pirris S, Flickinger JC, Lunsford LD: Gamma knife radiosurgery for benign tumors with symptoms from brainstem compression. Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):988-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for benign tumors with symptoms from brainstem compression.
  • PURPOSE: This study evaluated the role of radiosurgery in the management of symptomatic patients with brainstem compression from benign basal tumors.
  • METHODS AND MATERIALS: Over a 17-year, period 246 patients (202 vestibular schwannomas and 44 meningiomas) with brainstem compression from benign skull-base tumors were managed with Gamma Knife radiosurgery.
  • Median tumor volumes were 3.9 cm(3) (range, 0.8-39.0 mL) and 6.6 mL (range, 1.6-25.1 mL) for vestibular schwannomas and meningiomas, respectively.
  • For both tumors, a median marginal dose of 13 Gy was prescribed.
  • Patients were categorized into four groups on the basis of the tumor-brainstem relationship on neuroimaging.
  • The tumor control rate was 100 % for meningioma and 97% for vestibular schwannomas (although 5% required an additional procedure such as a ventriculoperitoneal shunt).
  • Balance improved significantly in patients who had less tumor compression (p = 0.0357) after radiosurgery.
  • CONCLUSION: Radiosurgery is a minimally invasive option for patients with benign basal tumors that indent or distort the brainstem.
  • A high tumor growth control rate and satisfactory rate of neurological preservation and symptom control can be obtained with radiosurgery.
  • [MeSH-major] Brain Stem. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Constriction, Pathologic / surgery. Female. Humans. Male. Middle Aged. Statistics, Nonparametric. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20381265.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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49. Rice JM: Inducible and transmissible genetic events and pediatric tumors of the nervous system. J Radiat Res; 2006;47 Suppl B:B1-11
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  • [Title] Inducible and transmissible genetic events and pediatric tumors of the nervous system.
  • Tumors of the nervous system most often occur in both children and adults as sporadic events with no family history of the disease, but they are also among the clinical manifestations of a significant number of familial cancer syndromes, including familial retinoblastoma, neurofibromatosis 1 and 2, tuberous sclerosis, and Cowden, Turcot, Li-Fraumeni and nevoid basal cell carcinoma (Gorlin) syndromes.
  • These genes include RB1, NF1, NF2, TSC1, TSC2, TP53, PTEN, APC, hMLH1, hPSM2, and PTCH, most of which function as tumor suppressor genes.
  • The same genes are also observed in mutated and inactive forms, or are deleted, in tumor cells in sporadic cases of the same tumors.
  • However, only external ionizing radiation at high doses is clearly established as an environmental cause of brain, nerve and meningeal tumors in humans.
  • Transplacental carcinogenesis studies in rodents and other species emphasize the extraordinary susceptibility of the developing mammalian nervous system to carcinogenesis, but the inverse relationship of latency to dose suggests that low transplacental exposures to genotoxicants are more likely to result in brain tumors late in life, rather than in childhood.
  • While not all neurogenic tumor-related genes in humans have similar effects in experimental rodents, genetically engineered mice (GEM) increasingly provide useful insights into the combined effects of multiple tumor suppressor genes and of gene-environment interactions in the genesis of brain tumors, especially pediatric brain tumors such as medulloblastoma.
  • [MeSH-minor] Adult. Animals. Base Sequence. Child. DNA, Neoplasm / genetics. Female. Genes, Tumor Suppressor. Genes, erbB-2. Humans. Mice. Mice, Transgenic. Mutation. Oncogenes. Pregnancy. Syndrome


50. Amendola BE, Wolf A, Coy SR, Amendola MA, Eber D: Pineal tumors: analysis of treatment results in 20 patients. J Neurosurg; 2005 Jan;102 Suppl:175-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pineal tumors: analysis of treatment results in 20 patients.
  • OBJECT: The authors evaluate their results when using gamma knife surgery (GKS) in the management of patients with tumors in the pineal region.
  • METHODS: This is a retrospective clinical evaluation of 20 patients with primary tumors of the pineal region treated with GKS from November 1994 through August 2003.
  • There were 13 germ cell tumors, two pineoblastomas, two low-grade gliomas, one primitive neuroectodermal tumor, one teratoma, and one pineocytoma.
  • Three patients died: one of unrelated causes, one who presented with extensive local disease, and the other of meningeal carcinomatosis with local control of the primary tumor.
  • CONCLUSIONS: This initial experience suggests that GKS is a valuable treatment modality for the management of pineal region tumors.
  • This technique offers excellent local tumor control and minimal patient morbidity, allowing for immediate use of systemic chemotherapy and/or conventional radiation if indicated.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Glioma / mortality. Glioma / pathology. Glioma / surgery. Humans. Hydrocephalus / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Neuroectodermal Tumors, Primitive / mortality. Neuroectodermal Tumors, Primitive / pathology. Neuroectodermal Tumors, Primitive / surgery. Radiation Dosage. Retrospective Studies. Survival Rate. Teratoma / mortality. Teratoma / pathology. Teratoma / surgery

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  • (PMID = 15662805.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Kaynar MY, Sanus GZ, Hnimoglu H, Kacira T, Kemerdere R, Atukeren P, Gumustas K, Canbaz B, Tanriverdi T: Expression of hypoxia inducible factor-1alpha in tumors of patients with glioblastoma multiforme and transitional meningioma. J Clin Neurosci; 2008 Sep;15(9):1036-42
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  • [Title] Expression of hypoxia inducible factor-1alpha in tumors of patients with glioblastoma multiforme and transitional meningioma.
  • There was no statistically significant difference between the two types of tumor (p=0.264).
  • These findings indicate that HIF-1alpha is elevated in both TM and GBM, suggesting that although hypoxia is one of the most important and powerful stimuli for HIF-1alpha elevation and consequently angiogenesis, other mechanisms may play roles in HIF-1alpha stimulation in benign brain tumors such as TM.
  • [MeSH-major] Brain Neoplasms / metabolism. Glioblastoma / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism
  • [MeSH-minor] Adult. Aged. Anoxia / diagnosis. Anoxia / metabolism. Anoxia / physiopathology. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cell Hypoxia / physiology. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neovascularization, Pathologic / etiology. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / physiopathology. Predictive Value of Tests. Up-Regulation / physiology

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  • (PMID = 18621534.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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52. Nasseri K, Mills JR: Epidemiology of primary brain tumors in the Middle Eastern population in California, USA 2001-2005. Cancer Detect Prev; 2009;32(5-6):363-71
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  • [Title] Epidemiology of primary brain tumors in the Middle Eastern population in California, USA 2001-2005.
  • The purpose of this study was to compare the epidemiology of primary brain tumors in this ethnic population with the non-Hispanic, non-Middle Eastern White (NHNMW) in California.
  • Data for 683 cases of primary brain tumors (429 benign, 238 malignant, 16 uncertain) in the ME and 15,589 cases (8352 benign, 6812 malignant, 425 uncertain) in the NHNMW were available for this study.
  • RESULTS: ME patients were significantly (p < 0.05) younger and their age-adjusted incidence rates per 100,000 for benign tumors of 10.0 in men and 17.6 in women were higher than similar rates of 7.3 and 10.6 in the NHNMW group (p < 0.05).
  • Rates for malignant tumors were similar.
  • Also increased were benign tumors of the pituitary and pineal glands.
  • The overall mortality in patients with benign tumors was significantly lower than malignant tumors.

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  • (PMID = 19588542.001).
  • [ISSN] 1525-1500
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA103457-02; United States / NCI NIH HHS / CA / CA103457; United States / NCI NIH HHS / PC / N01-PC-35139; United States / NCCDPHP CDC HHS / DP / U58 DP000807; United States / NCI NIH HHS / CA / N01PC54404; United States / NCI NIH HHS / CA / R03 CA103457-02; United States / NCI NIH HHS / CA / R03 CA103457; United States / NCI NIH HHS / CA / N01PC35136; United States / NCI NIH HHS / CA / N01PC35139; United States / NCI NIH HHS / PC / N01-PC-54404; United States / NCI NIH HHS / PC / N01-PC-35136; United States / NCCDPHP CDC HHS / DP / 1U58DP00807-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS140088; NLM/ PMC2785228
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53. Quiñones-Hinojosa A, Chang EF, Chaichana KL, McDermott MW: Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumors. Neurosurgery; 2009 May;64(5 Suppl 2):260-8; discussion 268
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  • [Title] Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumors.
  • OBJECTIVE: Meningiomas arising from the falcotentorial junction are relatively rare, and the description of the surgical nuances in approaching these tumors is limited.
  • The angiograms revealed that these tumors were fed by branches of the internal carotid artery, choroidal arteries, branches of the meningohypophyseal trunk, and branches of the posterior cerebral artery.
  • Two of the tumors (22%) recurred during a mean follow-up period of 49 months (range, 17-88 months).
  • [MeSH-major] Cranial Sinuses / surgery. Craniotomy / methods. Dura Mater / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Occipital Bone / surgery
  • [MeSH-minor] Adult. Aged. Blindness, Cortical / diagnosis. Blindness, Cortical / prevention & control. Cerebral Angiography. Dissection / methods. Female. Functional Laterality / physiology. Humans. Intraoperative Complications / prevention & control. Magnetic Resonance Imaging. Male. Middle Aged. Occipital Lobe / blood supply. Occipital Lobe / surgery. Outcome Assessment (Health Care). Postoperative Complications / prevention & control. Preoperative Care / methods. Surgical Flaps / standards. Surgical Instruments. Treatment Outcome

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  • (PMID = 19287325.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Luther N, Stetler WR Jr, Dunkel IJ, Christos PJ, Wellons JC 3rd, Souweidane MM: Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy. J Neurosurg Pediatr; 2010 Jan;5(1):61-7
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  • [Title] Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy.
  • OBJECT: Endoscopic biopsy with concomitant third ventriculostomy (ETV) is a well-established diagnostic and therapeutic maneuver in patients presenting with noncommunicating hydrocephalus resulting from a tumor of the pineal region or posterior third ventricle.
  • Fenestration of the floor of the third ventricle theoretically provides a conduit for the subarachnoid dissemination of an intraventricular tumor.
  • METHODS: The authors conducted a review of all patients for whom an ETV and simultaneous endoscopic biopsy procedure or tumor resection had been performed at their institutions between 1995 and 2008.
  • All available postoperative clinical and radiographic data, including MR imaging of the brain and spinal cord, as well as CSF sampling were evaluated when available.
  • New leptomeningeal disease (1 yolk sac tumor and 1 pineoblastoma) occurred in 2 patients.
  • The median clinical and brain MR imaging follow-ups overall were 34 (range 2-103 months) and 38 months (range 1-94 months), respectively.
  • CONCLUSIONS: The rate of leptomeningeal metastasis of tumors in this biopsy and ETV study was not increased when compared with rates from large series in the literature.
  • [MeSH-major] Biopsy / adverse effects. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / surgery. Endoscopy. Meningeal Neoplasms / secondary. Neoplasm Seeding. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Pinealoma / pathology. Pinealoma / surgery. Subarachnoid Space / pathology. Third Ventricle / pathology. Third Ventricle / surgery. Ventriculostomy / adverse effects
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20043737.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Greenberg E, Treger I, Ring H: Rehabilitation outcomes in patients with brain tumors and acute stroke: comparative study of inpatient rehabilitation. Am J Phys Med Rehabil; 2006 Jul;85(7):568-73
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  • [Title] Rehabilitation outcomes in patients with brain tumors and acute stroke: comparative study of inpatient rehabilitation.
  • OBJECTIVES: To investigate functional outcomes after hospital rehabilitation of patients surviving craniotomy for primary brain tumor excision compared with post-stroke patients.
  • DESIGN: The database of the Neurological Rehabilitation Department "C" of Loewenstein Rehabilitation Center was used to investigate primary brain tumors and first ischemic and hemorrhagic stroke patients admitted for hospital rehabilitation during an 11-yr period, between January 1993 and August 2004.
  • RESULTS: A total of 168 patients with craniotomy for primary brain tumor excision (128 intracranial meningiomas and 40 cerebral gliomas) and 1660 first-stroke patients were admitted to the department for rehabilitation during the study period.
  • CONCLUSIONS: Patients with brain tumors can achieve good functional outcomes with a shorter length of stay.

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  • (PMID = 16788387.001).
  • [ISSN] 0894-9115
  • [Journal-full-title] American journal of physical medicine & rehabilitation
  • [ISO-abbreviation] Am J Phys Med Rehabil
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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56. Sasayama T, Nishihara M, Tanaka K, Mizukawa K, Ehara K, Kanomata N, Kohmura E: Two metachronous tumors induced by radiation therapy: case report and review of the literature. J Neurooncol; 2008 Jul;88(3):315-20
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  • [Title] Two metachronous tumors induced by radiation therapy: case report and review of the literature.
  • Various radiation-induced tumors, including meningioma, glioma, and sarcoma, have been reported; however, metachronous intracranial double tumors induced by radiation therapy are extremely rare.
  • A 1-year-old boy had undergone tumor removal and craniospinal radiation therapy (30 Gy) for cerebellar medulloblastoma.
  • Six years later, an infiltrative tumor was newly found in the right fronto-temporal white matter.
  • The patient underwent stereotactic biopsy, and the tumor was found to be an anaplastic astrocytoma.
  • Since both secondary tumors were located within the area of previous radiation and the patient did not have any genetic disease predisposing him to tumors, radiation therapy was considered to be responsible for their tumorigenesis.
  • To our knowledge, this case is the fourth case of radiation-induced double CNS tumors arising after radiotherapy to be described in the literature.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adult. Age of Onset. Cerebellar Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Humans. In Situ Hybridization, Fluorescence. Infant. Loss of Heterozygosity. Magnetic Resonance Imaging. Male. Medulloblastoma / radiotherapy

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  • (PMID = 18373066.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Dave SP, Bared A, Casiano RR: Surgical outcomes and safety of transnasal endoscopic resection for anterior skull tumors. Otolaryngol Head Neck Surg; 2007 Jun;136(6):920-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcomes and safety of transnasal endoscopic resection for anterior skull tumors.
  • OBJECTIVE: To report the surgical outcomes and safety of transnasal endoscopic resection (TER) for anterior skull base (ASB) tumors.
  • STUDY DESIGN AND SETTING: A retrospective chart review to identify patients undergoing TER for ASB tumors at a tertiary care medical center between September 1997 and June 2006.
  • RESULTS: Nineteen patients underwent TER for ASB tumors without open craniotomy.
  • It should be noted that the tumor control rate may be premature given the small sample size and limited follow-up.
  • CONCLUSIONS: TER for ASB tumors appears to be safe in properly selected patients.
  • [MeSH-major] Carcinoma / surgery. Cranial Fossa, Anterior / surgery. Endoscopy. Esthesioneuroblastoma, Olfactory / surgery. Hemangiopericytoma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Nose Neoplasms / surgery. Postoperative Complications / etiology. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Survival Rate

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  • (PMID = 17547980.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Toh CH, Wong AM, Wei KC, Ng SH, Wong HF, Wan YL: Peritumoral edema of meningiomas and metastatic brain tumors: differences in diffusion characteristics evaluated with diffusion-tensor MR imaging. Neuroradiology; 2007 Jun;49(6):489-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peritumoral edema of meningiomas and metastatic brain tumors: differences in diffusion characteristics evaluated with diffusion-tensor MR imaging.
  • INTRODUCTION: We prospectively compared the fractional anisotropy (FA) and mean diffusivity (MD) of the peritumoral edema of meningiomas and metastatic brain tumors with diffusion-tensor magnetic resonance (MR) imaging.
  • Preoperative diffusion-tensor MR imaging was performed in 15 patients with meningiomas and 11 patients with metastatic brain tumors.
  • CONCLUSION: The peritumoral edema of metastatic brain tumors and meningiomas show different MD and FA on diffusion-tensor MR imaging.
  • [MeSH-major] Brain Edema / metabolism. Brain Edema / pathology. Brain Neoplasms / secondary. Meningeal Neoplasms / complications. Meningioma / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anisotropy. Diffusion. Diffusion Magnetic Resonance Imaging. Female. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 17310356.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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59. Wang Y, Kang L, Xiao L: Infrequent bilateral orbital tumors and simulating lesions: the experience of a Chinese institute. Jpn J Ophthalmol; 2009 Nov;53(6):629-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infrequent bilateral orbital tumors and simulating lesions: the experience of a Chinese institute.
  • RESULTS: The number and percentage of lesions in each general category were leukemia lesions in eight patients (19.5%), metastatic tumors in seven (17%), optic nerve and meningeal tumors in six (14.6%), secondary tumors in six (14.6%), peripheral nerve lesions in four (9.8%), inflammatory lesions in four (9.8%), and vasculogenic, histiocytic, and miscellaneous lesions, each in two patients (4.9%).
  • Of the 15 patients with either metastatic tumors or blood disorders, two (13.3%) had a history of primary neoplasm at presentation.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Child. Child, Preschool. China / epidemiology. Female. Functional Laterality. Humans. Incidence. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Sex Distribution. Tomography, X-Ray Computed

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  • (PMID = 20020243.001).
  • [ISSN] 1613-2246
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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60. Muller PJ, Wilson BC: Photodynamic therapy of brain tumors--a work in progress. Lasers Surg Med; 2006 Jun;38(5):384-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic therapy of brain tumors--a work in progress.
  • BACKGROUND AND OBJECTIVES: PDT has been used in the treatment of malignant brain tumors.
  • STUDY DESIGN AND METHODS: We examined the records of 112 patients with malignant gliomas, metastatic brain tumors and meningiomas treated with Photofrin-PDT at St. Michael's Hospital, Toronto.
  • [MeSH-major] Brain Neoplasms / drug therapy. Dihematoporphyrin Ether / therapeutic use. Photochemotherapy. Photosensitizing Agents / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma / drug therapy. Carcinoma / mortality. Carcinoma / secondary. Female. Glioma / drug therapy. Glioma / mortality. Humans. Male. Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / mortality. Meningioma / drug therapy. Meningioma / mortality. Middle Aged

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16788926.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA43892
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 97067-70-4 / Dihematoporphyrin Ether
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61. Kubo O, Chernov M, Izawa M, Hayashi M, Muragaki Y, Maruyama T, Hori T, Takakura K: Malignant progression of benign brain tumors after gamma knife radiosurgery: is it really caused by irradiation? Minim Invasive Neurosurg; 2005 Dec;48(6):334-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant progression of benign brain tumors after gamma knife radiosurgery: is it really caused by irradiation?
  • Malignant transformation of benign neoplasm after radiosurgery is usually diagnosed based on the initial presence of benign tumor, its exposure to ionizing radiation, elapsed time from radiation exposure to malignant progression, and different histological characteristics or growth rate of the regrowing tumor comparing with those originally treated.
  • Three presented cases fulfilled these diagnostic criteria; however, it seems that progression of the tumors (schwannoma, meningioma, chordoma) resulted from the natural course of the disease, rather than represented side effects of gamma knife radiosurgery.
  • Evaluation of the proliferative potential of the benign neoplasm before radiosurgical treatment either directly, if tumor sampling is available, or indirectly, by calculation of the tumor growth rate and/or analysis of the data of the metabolic imaging (PET, MRS) is important for identification of "aggressive" subtypes, precise prediction of prognosis, and confirmation of the radiation-induced malignant transformation in cases of tumor regrowth.
  • [MeSH-major] Brain Neoplasms / surgery. Cell Transformation, Neoplastic / radiation effects. Chordoma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasms, Radiation-Induced / physiopathology. Neurilemmoma / surgery. Radiosurgery / adverse effects
  • [MeSH-minor] Adult. Brain Diseases / surgery. Cell Proliferation. Female. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 16432782.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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62. Shinoura N, Tabei Y, Yamada R, Saito K, Takahashi M: Continuous intrathecal treatment with methotrexate via subcutaneous port: implication for leptomeningeal dissemination of malignant tumors. J Neurooncol; 2008 May;87(3):309-16
Hazardous Substances Data Bank. METHOTREXATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Continuous intrathecal treatment with methotrexate via subcutaneous port: implication for leptomeningeal dissemination of malignant tumors.
  • Use of intrathecal (IT) chemotherapy combined with radiotherapy can extend survival of patients with untreated leptomeningeal dissemination of malignant tumors from one month to two to six months.
  • In conclusion, CIT with 10 mg MTX via subcutaneous port for 5 days may improve the therapeutic effect and reduce the complications associated with treatment of leptomeningeal dissemination from malignant tumors.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / secondary. Methotrexate / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Injections, Spinal / methods. Kaplan-Meier Estimate. Male. Middle Aged. Neuronavigation

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  • (PMID = 18074105.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; YL5FZ2Y5U1 / Methotrexate
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63. Noguchi T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Nagao E, Shono T, Mizoguchi M, Nagata S, Sasaki T, Suzuki SO, Iwaki T, Kobayashi K, Mihara F, Honda H: Perfusion imaging of brain tumors using arterial spin-labeling: correlation with histopathologic vascular density. AJNR Am J Neuroradiol; 2008 Apr;29(4):688-93
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  • [Title] Perfusion imaging of brain tumors using arterial spin-labeling: correlation with histopathologic vascular density.
  • BACKGROUND AND PURPOSE: We investigated the relationship between tumor blood-flow measurement based on perfusion imaging by arterial spin-labeling (ASL-PI) and histopathologic findings in brain tumors.
  • MATERIALS AND METHODS: We used ASL-PI to examine 35 patients with brain tumors, including 11 gliomas, 9 meningiomas, 9 schwannomas, 1 diffuse large B-cell lymphoma, 4 hemangioblastomas, and 1 metastatic brain tumor.
  • As an index of tumor perfusion, the relative signal intensity (SI) of each tumor (%Signal intensity) was determined as a percentage of the maximal SI within the tumor per averaged SI within normal cerebral gray matter on ASL-PI.
  • Among gliomas, %Signal intensity was significantly higher for high-grade than for low-grade tumors (P < .05).
  • CONCLUSION: ASL-PI may predict histopathologic vascular densities of brain tumors and may be useful in distinguishing between high- and low-grade gliomas and in differentiating hemangioblastomas from other brain tumors.
  • [MeSH-major] Brain Neoplasms / blood supply. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Proliferation. Cerebrovascular Circulation. Child. Child, Preschool. Female. Glioma / blood supply. Glioma / pathology. Hemangioma / blood supply. Hemangioma / pathology. Humans. Male. Meningeal Neoplasms / blood supply. Meningeal Neoplasms / pathology. Meningioma / blood supply. Meningioma / pathology. Microcirculation / pathology. Middle Aged. Neurilemmoma / blood supply. Neurilemmoma / pathology. Spin Labels


64. Taylor AJ, Little MP, Winter DL, Sugden E, Ellison DW, Stiller CA, Stovall M, Frobisher C, Lancashire ER, Reulen RC, Hawkins MM: Population-based risks of CNS tumors in survivors of childhood cancer: the British Childhood Cancer Survivor Study. J Clin Oncol; 2010 Dec 20;28(36):5287-93
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  • [Title] Population-based risks of CNS tumors in survivors of childhood cancer: the British Childhood Cancer Survivor Study.
  • PURPOSE: CNS tumors are the most common second primary neoplasm (SPN) observed after childhood cancer in Britain, but the relationship of risk to doses of previous radiotherapy and chemotherapy is uncertain.
  • The risk of meningioma increased strongly, linearly, and independently with each of dose of radiation to meningeal tissue and dose of intrathecal methotrexate.
  • Those whose meningeal tissue received 0.01 to 9.99, 10.00 to 19.99, 20.00 to 29.99, 30.00 to 39.99 and≥40 Gy had risks that were two-fold, eight-fold, 52-fold, 568-fold, and 479-fold, respectively, the risks experienced by those whose meningeal tissue was unexposed.
  • The risk of glioma/primitive neuroectodermal tumors increased linearly with dose of radiation, and those who had CNS tissue exposed to at least 40 Gy experienced a risk four-fold that experienced by those who had CNS tissue unexposed.
  • CONCLUSION: The largest-ever study, to our knowledge, of CNS tumors in survivors of childhood cancer indicates that the risk of meningioma increases rapidly with increased dose of radiation to meningeal tissue and with increased dose of intrathecal methotrexate.

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  • (PMID = 21079138.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / ZIA CP010131-18; United Kingdom / Cancer Research UK / / ; United Kingdom / Department of Health / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
  • [Other-IDs] NLM/ NIHMS533866; NLM/ PMC4809645
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65. Davis F, Tavelin B, Grutsch J, Malmer B: Second primary tumors following a diagnosis of meningioma in Sweden, 1958-1997. Neuroepidemiology; 2007;29(1-2):101-6
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  • [Title] Second primary tumors following a diagnosis of meningioma in Sweden, 1958-1997.
  • This study quantifies the risk of second primary tumors following a diagnosis of meningioma.
  • Elevated and statistically significant SIRs were observed for renal cancer (SIR = 1.6), melanoma (SIR = 1.7), thyroid cancer (SIR = 2.6) and brain tumors (SIR = 2.6).
  • Radiation exposures increase the risk of these rare tumors, so quantifying the cumulative and shared effects of environmental and treatment exposures is of further interest.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasms, Second Primary / epidemiology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Female. Humans. Male. Middle Aged. Registries. Risk Factors. Sex Distribution. Sweden / epidemiology. Time Factors

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17940341.001).
  • [ISSN] 1423-0208
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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66. Spreafico F, Gandola L, Marchianò A, Simonetti F, Poggi G, Adduci A, Clerici CA, Luksch R, Biassoni V, Meazza C, Catania S, Terenziani M, Musumeci R, Fossati-Bellani F, Massimino M: Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors. Int J Radiat Oncol Biol Phys; 2008 Mar 15;70(4):1011-9
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  • [Title] Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors.
  • PURPOSE: Brain necrosis or other subacute iatrogenic reactions has been recognized as a potential complication of radiotherapy (RT), although the possible synergistic effects of high-dose chemotherapy and RT might have been underestimated.
  • METHODS AND MATERIALS: We reviewed the clinical and radiologic data of 49 consecutive children with malignant brain tumors treated with high-dose thiotepa and autologous hematopoietic stem cell rescue, preceded or followed by RT.
  • RESULTS: Of the 49 children, 18 (6 of 25 with high-grade gliomas and 12 of 24 with primitive neuroectodermal tumors) had abnormal brain MRI findings occurring a median of 8 months (range, 2-39 months) after RT and beginning to regress a median of 13 months (range, 2-26 months) after onset.
  • Four patients with primitive neuroectodermal tumors also had subdural fluid leaks, with meningeal enhancement over the effusion.
  • Such findings pose a major diagnostic challenge in terms of their differential diagnosis vis-à-vis recurrent tumor.
  • [MeSH-major] Antineoplastic Agents, Alkylating / adverse effects. Brain. Brain Neoplasms. Glioma. Neuroectodermal Tumors, Primitive. Thiotepa / adverse effects
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Cognition / drug effects. Cognition / radiation effects. Combined Modality Therapy / adverse effects. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Infant. Intelligence / drug effects. Intelligence / radiation effects. Magnetic Resonance Imaging. Male. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy

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  • (PMID = 17904307.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 905Z5W3GKH / Thiotepa
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67. Jensen AW, Brown PD, Pollock BE, Stafford SL, Link MJ, Garces YI, Foote RL, Gorman DA, Schomberg PJ: Gamma knife radiosurgery of radiation-induced intracranial tumors: local control, outcomes, and complications. Int J Radiat Oncol Biol Phys; 2005 May 1;62(1):32-7
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  • [Title] Gamma knife radiosurgery of radiation-induced intracranial tumors: local control, outcomes, and complications.
  • PURPOSE: To determine local control (LC) and complication rates for patients who underwent radiosurgery for radiation-induced intracranial tumors.
  • METHODS AND MATERIALS: Review of a prospectively maintained database (2,714 patients) identified 16 patients (20 tumors) with radiation-induced tumors treated with radiosurgery between 1990 and 2004.
  • Tumor types included typical meningioma (n=17), atypical meningioma (n=2), and schwannoma (n=1).
  • The median tumor margin dose was 16 Gy (range, 12-20 Gy).
  • Three patients died: 1 had in-field progression 65.1 months after radiosurgery and later died of the tumor, 1 died of progression of a preexisting brain malignancy, and 1 died of an unrelated cause.
  • Radiosurgery is a safe and effective treatment option for radiation-induced intracranial tumors, most of which are typical meningiomas.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasms, Radiation-Induced / surgery. Neurilemmoma / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Survival Rate. Treatment Outcome

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  • (PMID = 15850899.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Kwon Y, Bae JS, Kim JM, Lee DH, Kim SY, Ahn JS, Kim JH, Kim CJ, Kwun BD, Lee JK: Visual changes after gamma knife surgery for optic nerve tumors. Report of three cases. J Neurosurg; 2005 Jan;102 Suppl:143-6
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  • [Title] Visual changes after gamma knife surgery for optic nerve tumors. Report of three cases.
  • Tumors involving the optic nerve (optic glioma, optic nerve sheath meningioma) are benign but difficult to treat.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Exophthalmos / etiology. Meningeal Neoplasms / surgery. Meningioma / surgery. Optic Nerve Glioma / surgery. Optic Nerve Neoplasms / surgery. Postoperative Complications. Radiosurgery / instrumentation. Vision Disorders / etiology
  • [MeSH-minor] Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Radiation Dosage. Tumor Burden / radiation effects. Visual Acuity / physiology

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  • (PMID = 15662798.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Kim KE, Kim KU, Kim DC, Park JI, Han JY: Cytogenetic characterizations of central nervous system tumors: the first comprehensive report from a single institution in Korea. J Korean Med Sci; 2009 Jun;24(3):453-60

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  • [Title] Cytogenetic characterizations of central nervous system tumors: the first comprehensive report from a single institution in Korea.
  • The World Health Organization (WHO) classification of central nervous system (CNS) tumors incorporates morphology, cytogenetics, molecular genetics, and immunologic markers.
  • Despite the relatively large number of CNS tumors with clonal chromosome abnormalities, only few studies have investigated cytogenetic abnormalities for CNS tumors in Korea.
  • Thus, we investigated 119 CNS tumors by conventional G-banded karyotypes to characterize patterns of chromosomal abnormalities involving various CNS tumors, and 92.4% of them were cultured and karyotyped successfully.
  • Totally, 51.8% of karyotypable CNS tumors showed abnormal cytogenetic results, including neuroepithelial tumors (75.0%), meningeal tumors (71.1%), pituitary adenomas (4.2%), schwannomas (44.4%), and metastatic tumors (100.0%).
  • Abnormal karyotypes were more complex at high-grade tumors, suggesting that the karyotype reflects the biologic nature of the tumor.
  • More detailed cytogenetic and molecular characterizations of CNS tumors contribute to better diagnostic criteria and deeper insights of tumorigenesis, eventually resulting in development of novel therapeutic strategies.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Glioblastoma / genetics. Humans. Karyotyping. Korea. Male. Meningeal Neoplasms / genetics. Middle Aged. Neurilemmoma / genetics. Pituitary Neoplasms / genetics

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  • (PMID = 19543509.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2698192
  • [Keywords] NOTNLM ; Central Nervous System Neoplasms / Chromosome Abnormality / Karyotype / Solid Tumor / WHO Classification
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70. Saceda-Gutiérrez JM, Isla-Guerrero AJ, Pérez-López C, Ortega-Martínez R, Gómez de la Riva A, Gandia-González ML, Gutiérrez-Molina M, Rey-Herranz JA: [Solitary fibrous tumors of the meninges: report of three cases and literature review]. Neurocirugia (Astur); 2007 Dec;18(6):496-504
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  • [Title] [Solitary fibrous tumors of the meninges: report of three cases and literature review].
  • [Transliterated title] Tumor fibroso solitario meníngeo: descripción de tres casos y revisión de la literatura.
  • We report 3 patients with fibrous solitary tumor of meningeal location where we described the histological study, as well as evolution after the surgical treatment.
  • Checking the literature the tumor is indistinguishable clinical and radiolocally of the typical meningioma, doing necessary the use of inmunohistochemistry to do the differential diagnosis, where positiveness for CD34 and the negativeness for EMA define the fibrous solitary tumor.
  • It is about a benign tumor, where total removing is the principal factor in prognosis, nevertheless there are cases of local recurrences and long-distance metastasis.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningeal Neoplasms / radiography. Solitary Fibrous Tumors / pathology. Solitary Fibrous Tumors / radiography
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures / methods. Tomography, X-Ray Computed

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  • (PMID = 18094909.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 46
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71. Wiggenraad RG, Petoukhova AL, Versluis L, van Santvoort JP: Stereotactic radiotherapy of intracranial tumors: a comparison of intensity-modulated radiotherapy and dynamic conformal arc. Int J Radiat Oncol Biol Phys; 2009 Jul 15;74(4):1018-26
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  • [Title] Stereotactic radiotherapy of intracranial tumors: a comparison of intensity-modulated radiotherapy and dynamic conformal arc.
  • The purpose of this planning study is to examine the relative merits of these techniques in the treatment of intracranial tumors.
  • RESULTS: In the overall comparison of both techniques, we found adequate target coverage in all cases; a better mean CI with IMRT in concave tumors (p = 0.027); a better mean HI with DCA in meningiomas, complex tumors, and small (< 92 mL) tumors (p = 0.000, p = 0.005, and p = 0.005, respectively); and a higher EUD in the PTV with DCA in convex tumors (gliomas) and large tumors (p = 0.000 and p = 0.003, respectively).
  • CONCLUSIONS: DCA is our preferred SRT technique for most intracranial tumors.
  • Tumor type, size, or shape do not predict a preference for DCA or IMRT.
  • [MeSH-major] Brain Neoplasms. Glioma. Meningeal Neoplasms. Meningioma. Radiosurgery / methods. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Radiotherapy Planning, Computer-Assisted. Tumor Burden. Young Adult

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  • (PMID = 19217219.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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72. Oechsle K, Lange-Brock V, Kruell A, Bokemeyer C, de Wit M: Prognostic factors and treatment options in patients with leptomeningeal metastases of different primary tumors: a retrospective analysis. J Cancer Res Clin Oncol; 2010 Nov;136(11):1729-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and treatment options in patients with leptomeningeal metastases of different primary tumors: a retrospective analysis.
  • METHODS: Single center data on characteristics, treatment and outcome of 135 consecutive pts (73 solid tumors and 62 hematologic malignancies) with LM between 1989 and 2005 were retrospectively analyzed.
  • Univariate analysis revealed age >50, interval between diagnosis of primary tumor and LM ≤12 months, lung cancer and malignant melanoma, and Karnofsky performance status ≤70 as significant negative predictors for overall survival.
  • CONCLUSIONS: In patients with LM an age >50, performance status ≤70%, interval between diagnosis of primary tumor and LM ≤12 months, primary tumor (lung cancer, malignant melanoma) and lack of cytologic response present negative prognostic factors.
  • [MeSH-major] Meningeal Carcinomatosis / pathology. Neoplasm Metastasis / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Hematologic Neoplasms / drug therapy. Hematologic Neoplasms / mortality. Hematologic Neoplasms / pathology. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / mortality. Lung Neoplasms / pathology. Lung Neoplasms / radiotherapy. Male. Melanoma / drug therapy. Melanoma / mortality. Melanoma / pathology. Melanoma / radiotherapy. Middle Aged. Neoplasms / drug therapy. Neoplasms / mortality. Neoplasms / pathology. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 20204406.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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73. Huang CF, Tu HT, Liu WS, Lin LY: Gamma Knife surgery for trigeminal pain caused by benign brain tumors. J Neurosurg; 2008 Dec;109 Suppl:154-9
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  • [Title] Gamma Knife surgery for trigeminal pain caused by benign brain tumors.
  • OBJECT: The authors report the effects of Gamma Knife surgery (GKS) on benign tumor-related trigeminal pain in patients who underwent follow-up for a mean 57.8 months.
  • METHODS: From 1999 to 2004, 21 patients with benign tumor-related trigeminal pain (12 meningiomas and 9 schwannomas) underwent GKS as a primary or repeated treatment.
  • These patients harbored tumors within the radiosurgical target area.
  • For meningiomas, the mean radiosurgical treatment volume was 8.2 ml (range 1.1-21 ml), and the mean radiosurgical tumor margin dose was 12.7 Gy (range 12-15 Gy); for schwannomas, the mean volume was 5.6 ml (range 2-9.2 ml), and the mean marginal dose was 13 Gy (range 11.5-16 Gy).
  • For all 21 patients (100%), control of tumor growth was documented at a mean of 46 months after GKS.
  • CONCLUSIONS: Gamma Knife surgery appears to be an effective tool to treat benign tumor-related trigeminal pain and control tumor growth.
  • [MeSH-major] Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neurilemmoma / surgery. Radiosurgery. Trigeminal Neuralgia / prevention & control
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pain, Intractable / etiology. Pain, Intractable / prevention & control. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 19123903.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Castelli J, Thariat J, Benezery K, Courdi A, Chanalet S, Paquis P, Doyen J, Frenay M, Mammar H, Bondiau PY: [Spinals and paraspinals tumors treated by CyberKnife: feasibility and efficacy]. Cancer Radiother; 2010 Jan;14(1):5-10

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  • [Title] [Spinals and paraspinals tumors treated by CyberKnife: feasibility and efficacy].
  • [MeSH-minor] Adult. Aged. Chordoma / mortality. Chordoma / surgery. Disease-Free Survival. Feasibility Studies. Female. Hemangioma / mortality. Hemangioma / surgery. Humans. Male. Meningeal Neoplasms / mortality. Meningeal Neoplasms / surgery. Meningioma / mortality. Meningioma / surgery. Middle Aged. Neoplasm Metastasis. Neurilemmoma / mortality. Neurilemmoma / surgery. Osteosarcoma / mortality. Osteosarcoma / surgery. Radiation Dosage. Radiometry

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  • [Copyright] 2009 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20005764.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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75. Feldman SC, Chu D, Schulder M, Pawar R, Barry M, Cho E-, Liu W-: The blood oxygen level-dependent functional MR imaging signal can be used to identify brain tumors and distinguish them from normal tissue. AJNR Am J Neuroradiol; 2009 Feb;30(2):389-95
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  • [Title] The blood oxygen level-dependent functional MR imaging signal can be used to identify brain tumors and distinguish them from normal tissue.
  • BACKGROUND AND PURPOSE: In neuro-oncology, a major problem is clear identification of tumor from the surrounding normal tissue.
  • We hypothesized that we could use the blood oxygen level-dependent functional MR imaging (BOLD fMRI) signals from tumors and normal brain to identify the tumors and distinguish them from the surrounding brain.
  • MATERIALS AND METHODS: Fourteen patients with meningiomas, gliomas, and metastatic tumors were scanned before surgery.
  • The BOLD signals were taken from selected points within the tumor and from the surrounding normal brain and were analyzed by using correlation analysis to determine how closely they were related.
  • RESULTS: The BOLD signals from all of the tumors were significantly different from those in the surrounding normal tissue.
  • In meningiomas and gliomas, selection of a voxel in the tumor for signal-intensity analysis highlighted the entire tumor mass while excluding the normal tissue.
  • CONCLUSIONS: Analysis of the BOLD signal intensity provides a relatively simple and straightforward method for identifying brain tumors and distinguishing them from normal tissue.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / metabolism. Glioma / diagnosis. Glioma / metabolism. Magnetic Resonance Imaging / methods. Oxygen / blood
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Adult. Female. Humans. Male. Melanoma / diagnosis. Melanoma / metabolism. Melanoma / secondary. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / metabolism. Meningioma / diagnosis. Meningioma / metabolism. Middle Aged. Retrospective Studies. Skin Neoplasms / pathology

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  • [ErratumIn] AJNR Am J Neuroradiol. 2009 Aug;30(7):E111. Pawar R [added]
  • (PMID = 19208905.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] S88TT14065 / Oxygen
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76. Mainio A, Hakko H, Niemelä A, Koivukangas J, Räsänen P: Depression and functional outcome in patients with brain tumors: a population-based 1-year follow-up study. J Neurosurg; 2005 Nov;103(5):841-7
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  • [Title] Depression and functional outcome in patients with brain tumors: a population-based 1-year follow-up study.
  • METHODS: The study population consisted of 77 patients with a solitary primary brain tumor treated surgically at the Oulu Clinic for Neurosurgery.
  • Each patient's depressive status, according to the Beck Depression Inventory (BDI), and functional outcome, based on the Karnofsky Performance Scale (KPS), were evaluated before the tumor was surgically treated as well as 3 months and 1 year after surgery.
  • The decrease in the level of depression was significant in patients with an anterior tumor (p = 0.049) and those with a pituitary adenoma (p = 0.019).
  • CONCLUSIONS: Affective disorders among patients with brain tumors must be considered immediately after surgery, especially in persons with a depression history and in those with a coincident physical disability.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / psychology. Depressive Disorder / epidemiology. Disability Evaluation. Glioma / epidemiology. Glioma / psychology
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / psychology. Adenoma / surgery. Adult. Female. Follow-Up Studies. Humans. Incidence. Male. Meningeal Neoplasms / epidemiology. Meningeal Neoplasms / psychology. Meningeal Neoplasms / surgery. Meningioma / epidemiology. Meningioma / psychology. Meningioma / surgery. Middle Aged. Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / psychology. Neuroma, Acoustic / surgery. Pituitary Neoplasms / epidemiology. Pituitary Neoplasms / psychology. Pituitary Neoplasms / surgery. Recovery of Function. Sex Distribution. Treatment Outcome

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  • (PMID = 16304988.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Sasao A, Hirai T, Nishimura S, Fukuoka H, Murakami R, Kitajima M, Okuda T, Akter M, Morioka M, Yano S, Nakamura H, Makino K, Kuratsu JI, Awai K, Yamashita Y: Assessment of vascular supply of hypervascular extra-axial brain tumors with 3T MR regional perfusion imaging. AJNR Am J Neuroradiol; 2010 Mar;31(3):554-8
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  • [Title] Assessment of vascular supply of hypervascular extra-axial brain tumors with 3T MR regional perfusion imaging.
  • BACKGROUND AND PURPOSE: The vascular supply of extra-axial brain tumors provided by the external carotid artery has not been studied with RPI.
  • The purpose of this work was to determine whether RPI assessment is feasible and provides information on the vascular supply of hypervascular extra-axial brain tumors.
  • Two neuroradiologists independently evaluated the overall image quality, the degree of tumor perfusion, and the extent of the tumor vascular territory on conventional ASL and RPI.
  • In comparisons of the vascular tumor territory identified by the conventional ASL and RPI techniques, the territories coincided in 3 cases, were partially different in 4, and completely different in 1.
  • CONCLUSIONS: RPI with selective labeling of the external carotid artery is feasible and may provide information about the vascular supply of hypervascular extra-axial brain tumors.
  • [MeSH-major] Magnetic Resonance Angiography. Magnetic Resonance Imaging / methods. Meningeal Neoplasms / blood supply. Meningeal Neoplasms / pathology. Meningioma / blood supply. Meningioma / pathology
  • [MeSH-minor] Adult. Aged. Angiography, Digital Subtraction. Carotid Artery, External / radiography. Carotid Artery, Internal / radiography. Cavernous Sinus / pathology. Feasibility Studies. Female. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Preoperative Care

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  • (PMID = 19850766.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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78. Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD: DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol; 2010 Jan;12(1):37-48
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  • [Title] DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
  • Although the etiology of primary brain tumors is largely unknown, prior studies suggest that DNA repair polymorphisms may influence risk of glioma.
  • Altered DNA repair is also likely to affect the risk of meningioma and acoustic neuroma, but these tumors have not been well studied.
  • Our results suggest that common DNA repair variants may affect the risk of adult brain tumors, especially meningioma.


79. Butturini AM, Jacob M, Aguajo J, Vander-Walde NA, Villablanca J, Jubran R, Erdreich-Epstein A, Marachelian A, Dhall G, Finlay JL: High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome. Cancer; 2009 Jul 1;115(13):2956-63
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  • [Title] High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome.
  • BACKGROUND: The role of myeloablative chemotherapy in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors (MB/ST-PNET) is controversial, in particular in patients who develop recurrent disease after craniospinal radiotherapy.
  • Nine previously irradiated children experienced 4 toxic deaths and 6 tumor recurrences (1 patient had both): An interval of <1 year between initial radiotherapy and myeloablative chemotherapy predicted a greater risk of toxic death (P = .02), whereas a history of meningeal metastases at diagnosis and a poor response to the initial rescue therapy predicted a greater risk of post-transplant recurrence (P = .03 and P = .08, respectively).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cranial Irradiation. Hematopoietic Stem Cell Transplantation. Medulloblastoma / therapy. Neuroectodermal Tumors, Primitive / therapy. Supratentorial Neoplasms / therapy. Thiotepa / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Infant. Male. Neoplasm Recurrence, Local. Survival Rate

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  • (PMID = 19402050.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 905Z5W3GKH / Thiotepa
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80. Yang DL, Xu QW, Che XM, Wu JS, Sun B: Clinical evaluation and follow-up outcome of presurgical plan by Dextroscope: a prospective controlled study in patients with skull base tumors. Surg Neurol; 2009 Dec;72(6):682-9; discussion 689
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  • [Title] Clinical evaluation and follow-up outcome of presurgical plan by Dextroscope: a prospective controlled study in patients with skull base tumors.
  • BACKGROUND: Patient-specific approach design, comprehensive evaluation on perioperative data, and follow-up of postoperative life quality (KPS) were carried out to evaluate the application of VR technology of Dextroscope in procedures of patients with skull base tumors.
  • METHODS: Eighty-four patients with skull base tumors involved in this research were randomized into 2 groups (test group and control group), each with 42 patients.
  • The resection rate of tumors, preoperative evaluation including the duration of operation, total blood loss, the postoperative LOS, the number of cases with cerebrovascular injury complications in operation, and postoperative KPS of patients on discharge and the sixth month follow-up in the 2 groups were recorded and compared.
  • RESULTS: The total resection rate of tumors was 83.33% in test group and 71.42% in the control group (P > .05).
  • CONCLUSION: The preoperative plans with VR technology in patients with skull base tumor or CSF leakage operations can help certain the diagnosis, individually locate the position of skull base lesions, and design patient-specific approach, which also facilitate to shorten operation duration and the postoperative LOS, reduce total blood loss and injury of vessels in operation, and improve the postoperative KPS.
  • [MeSH-minor] Adolescent. Adult. Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. China. Equipment Design. Female. Follow-Up Studies. Fourth Ventricle / pathology. Fourth Ventricle / surgery. Hemangioblastoma / diagnosis. Hemangioblastoma / surgery. Humans. Length of Stay. Male. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / surgery. Meningioma / diagnosis. Meningioma / surgery. Middle Aged. Neurilemmoma / diagnosis. Neurilemmoma / surgery. Postoperative Complications / etiology. Prospective Studies. Quality of Life

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  • [Copyright] Copyright 2009. Published by Elsevier Inc.
  • (PMID = 19850330.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Engelhard HH, Villano JL, Porter KR, Stewart AK, Barua M, Barker FG, Newton HB: Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina. J Neurosurg Spine; 2010 Jul;13(1):67-77
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  • [Title] Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina.
  • OBJECT Patients having a primary tumor of the spinal cord, spinal meninges or cauda equina, are relatively rare.
  • Neurosurgeons encounter and treat such patients, and need to be aware of their clinical presentation, tumor types, treatment options, and potential complications.
  • The purpose of this paper is to report results from a series of 430 patients with primary intraspinal tumors, taken from a larger cohort of 9661 patients with primary tumors of the CNS.
  • Intraspinal tumor cases were identified based on ICD-O-2 topography codes C70.1, C72.0, and C72.1.
  • RESULTS Patients with primary intraspinal tumors represented 4.5% of the CNS tumor group, and had a mean age of 49.3 years.
  • Pain was the most common presenting symptom, while the most common tumor types were meningioma (24.4%), ependymoma (23.7%), and schwannoma (21.2%).
  • [MeSH-major] Cauda Equina / pathology. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Chi-Square Distribution. Child. Child, Preschool. Ependymoma / epidemiology. Ependymoma / pathology. Ependymoma / surgery. Female. Humans. Infant. Male. Meningioma / epidemiology. Meningioma / pathology. Meningioma / surgery. Middle Aged. Neurilemmoma / epidemiology. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications / epidemiology. Prospective Studies. Radiotherapy, Adjuvant. Registries. Risk Factors. Treatment Outcome. United States / epidemiology

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  • (PMID = 20594020.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Maillo A, Orfao A, Espinosa AB, Sayagués JM, Merino M, Sousa P, Lara M, Tabernero MD: Early recurrences in histologically benign/grade I meningiomas are associated with large tumors and coexistence of monosomy 14 and del(1p36) in the ancestral tumor cell clone. Neuro Oncol; 2007 Oct;9(4):438-46

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  • [Title] Early recurrences in histologically benign/grade I meningiomas are associated with large tumors and coexistence of monosomy 14 and del(1p36) in the ancestral tumor cell clone.
  • Tumor recurrence is the major clinical complication in meningiomas, and its prediction in histologically benign/grade I tumors remains a challenge.
  • In this study, we analyzed the prognostic value of specific chromosomal abnormalities and the genetic heterogeneity of the tumor, together with other clinicobiological disease features, for predicting early relapses in histologically benign/grade I meningiomas.
  • A total of 149 consecutive histologically benign/grade I meningiomas in patients who underwent complete tumor resection were prospectively analyzed.
  • Similarly, histologically benign/grade I meningiomas showing coexistence of monosomy 14 and del(1p36) in the ancestral tumor cell clone displayed a higher frequency of early relapses.
  • In fact, coexistence of -14 and del(1p36) in the ancestral tumor cell clone, together with tumor size, represented the best combination of independent prognostic factors for the identification of those patients with a high risk of an early relapse.
  • Our results indicate that patients with large histologically benign/grade I meningiomas carrying monosomy 14 and del(1p36) in their ancestral tumor cell clone have a high probability of relapsing early after diagnostic surgery.
  • [MeSH-major] Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 14 / genetics. Meningeal Neoplasms / genetics. Meningioma / genetics. Neoplasm Recurrence, Local / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chromosome Aberrations. Chromosome Deletion. Clone Cells. Female. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Male. Middle Aged. Monosomy. Prognosis

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  • (PMID = 17704362.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1994101
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83. Cassereau J, Lavigne C, Michalak-Provost S, Ghali A, Dubas F, Fournier HD: An intraventricular clear cell meningioma revealed by an inflammatory syndrome in a male adult: a case report. Clin Neurol Neurosurg; 2008 Jul;110(7):743-6
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  • [Title] An intraventricular clear cell meningioma revealed by an inflammatory syndrome in a male adult: a case report.
  • Intraventricular meningiomas are infrequent intracranial tumors.
  • Clinical symptoms are mainly due to an increased intracranial pressure or a direct pressure on the surrounding brain structures.
  • Clinical and biological normalization was rapidly obtained after tumor removal.
  • Immunohistochemical examination showed tumor cells and lymphocytes positivity for the pyrogenic cytokine interleukin-6, with a same intensity.
  • To our knowledge, this is the first case described in the literature concerning an adult man with an intraventricular clear cell meningioma associated with a systemic inflammatory syndrome.
  • [MeSH-major] Inflammation / pathology. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 18514392.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Interleukin-6
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84. Prayson RA, Chamberlain WA, Angelov L: Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma. Appl Immunohistochem Mol Morphol; 2010 Oct;18(5):422-8
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  • [Title] Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma.
  • All tumors had at least a 10% clear cell component (mean 41%).
  • All tumors showed a sheet-like growth pattern.
  • Seven tumors (38.9%) showed CA9 immunoreactivity, 5 tumors (27.8%) CD10 staining, and 0 cases showed RCC staining.
  • In the majority of cases in which immunostaining was observed in meningiomas, staining was focal (involving <5% of neoplastic cells) in comparison with CA9 and CA10 immunostaining in renal cell carcinomas in which more than 50% of tumor cells stained the majority of cases.

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  • (PMID = 20453815.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.4.24.11 / Neprilysin; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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85. Dusick JR, Fatemi N, Mattozo C, McArthur D, Cohan P, Wang C, Swerdloff RS, Kelly DF: Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas. Surg Neurol; 2008 Nov;70(5):482-90; discussion 490-1
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  • [Title] Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas.
  • Patient characteristics, tumor size, intraoperative and postoperative events, and extent of tumor resection were correlated with new or resolved hypopituitarism.
  • [MeSH-major] Central Nervous System Cysts / surgery. Craniopharyngioma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Pituitary Gland / physiopathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cohort Studies. Female. Humans. Male. Middle Aged. Pituitary Function Tests. Pituitary Hormones, Anterior / metabolism. Pituitary Hormones, Posterior / metabolism. Retrospective Studies. Treatment Outcome

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  • [CommentIn] Surg Neurol. 2009 Dec;72(6):643-4; author reply 644-7 [20082835.001]
  • (PMID = 18482750.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pituitary Hormones, Anterior; 0 / Pituitary Hormones, Posterior
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86. Christensen HC, Schüz J, Kosteljanetz M, Poulsen HS, Boice JD Jr, McLaughlin JK, Johansen C: Cellular telephones and risk for brain tumors: a population-based, incident case-control study. Neurology; 2005 Apr 12;64(7):1189-95
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  • [Title] Cellular telephones and risk for brain tumors: a population-based, incident case-control study.
  • [MeSH-major] Brain Neoplasms / epidemiology. Cell Phones / statistics & numerical data. Glioma / epidemiology. Meningeal Neoplasms / epidemiology. Meningioma / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Case-Control Studies. Causality. Cohort Studies. Denmark / epidemiology. Electromagnetic Fields / adverse effects. Female. Humans. Male. Middle Aged. Odds Ratio. Risk Factors. Sex Distribution. Social Class

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  • [CommentIn] Neurology. 2006 Mar 14;66(5):781 [16534134.001]
  • [ErratumIn] Neurology. 2005 Oct 25;65(8):1324
  • (PMID = 15824345.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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87. Jouanneau E, Guzman Tovar RA, Desuzinges C, Frappaz D, Louis-Tisserand G, Sunyach MP, Jouvet A, Sindou M: Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report. Neurosurgery; 2006 Apr;58(4):E789; discussion E789
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  • [Title] Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report.
  • OBJECTIVE AND IMPORTANCE: We present a rare case of very long-term medulloblastoma relapse in an adult patient and discuss the pattern of recurrence and metabolic imaging of the tumor.
  • CLINICAL PRESENTATION: A 45-year-old man was referred for evaluation of a frontobasal midline tumor 21 years after treatment of a cerebellar medulloblastoma by surgery followed by chemotherapy and craniospinal radiotherapy.
  • Several hypotheses were discussed, such as other radio-induced tumors, sarcomas, high-grade gliomas, or lymphomas (previous chemotherapy) and even recurrence of medulloblastoma.
  • On diffusion imaging, the tumor appeared hyperintense, with a low apparent diffusion coefficient value of 0.689.
  • The patient underwent complete removal of the tumor that was confirmed to be a metastasis of his primary medulloblastoma.
  • CONCLUSION: Late relapse should be considered, even after several decades, on occurrence of a second intracranial tumor in this context.
  • Our observation validates the clinical interest of preoperative metabolic imaging for brain tumors with distinctive pattern.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 16575298.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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88. Phuphanich S, Maria B, Braeckman R, Chamberlain M: A pharmacokinetic study of intra-CSF administered encapsulated cytarabine (DepoCyt) for the treatment of neoplastic meningitis in patients with leukemia, lymphoma, or solid tumors as part of a phase III study. J Neurooncol; 2007 Jan;81(2):201-8
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  • [Title] A pharmacokinetic study of intra-CSF administered encapsulated cytarabine (DepoCyt) for the treatment of neoplastic meningitis in patients with leukemia, lymphoma, or solid tumors as part of a phase III study.
  • Cerebrospinal fluid (CSF) samples were collected from eight adult patients at various times up to 14 days after each dose.
  • CONCLUSIONS: The administration of intrathecal encapsulation cytarabine prolongs sustained tumor exposure to cytotoxic concentrations of cytarabine (>0.02 microg/ml) with a slow continuous release of cytarabine from the DepoFoam particles, so drug exposure is prolonged over time, resulting in lower peak cytarabine levels and a longer duration of exposure compared with standard cytarabine (Ara-C).
  • [MeSH-major] Antimetabolites, Antineoplastic / pharmacokinetics. Cytarabine / pharmacokinetics. Leukemia / metabolism. Lymphoma / metabolism. Meningeal Neoplasms / metabolism. Meningitis / metabolism
  • [MeSH-minor] Adult. Aged. Delayed-Action Preparations. Disease Progression. Female. Humans. Injections, Spinal. Male. Middle Aged

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  • (PMID = 16941075.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
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89. Kim AV, Shim KV, Kim DS, Khachaturian VA, Choĭ DY: [The leptomeningeal form of primary neuroectodermal tumor]. Zh Vopr Neirokhir Im N N Burdenko; 2007 Jan-Mar;(1):45-8; discussion 48

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  • [Title] [The leptomeningeal form of primary neuroectodermal tumor].
  • Brain neoplasms as primary leptomeningeal forms are rare, particularly if the case in point is primary neuroectodermal tumors (PNET).
  • Brain computed tomography and magnetic resonance imaging (MRI) revealed internal hydrocephalus and slightly uniform meningeal thickening without the signs of space-occupying lesions.
  • MRI showed a pronounced diffuse non-uniform leptomeningeal dissemination of a tumor.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / surgery. Neuroectodermal Tumors, Primitive / diagnosis. Neuroectodermal Tumors, Primitive / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Ventriculostomy

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  • (PMID = 17526253.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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90. Thompson EM, Sather MD, Reyes CA, Long DJ: Intracranial leptomeningeal metastasis from thymic carcinoma: case report and review. Surg Neurol; 2007 Aug;68(2):233-8
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  • BACKGROUND: Thymic carcinoma is an uncommon malignant tumor of the anterior mediastinum.
  • Meningeal metastasis from this type of neoplasm is extraordinarily rare and the prognosis is abysmal.
  • An MRI scan was highly suggestive of a meningioma, and it was initially suspected that this patient had 2 primary tumors.
  • CONCLUSION: The authors report a case of intracranial meningeal metastasis from a lymphoepithelioma-like poorly differentiated metastatic thymic carcinoma, which was treated by resection and WBRT.
  • [MeSH-major] Carcinoma / secondary. Meningeal Neoplasms / secondary. Thymus Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17537485.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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91. D'Haene N, Coen N, Neugroschl C, Balériaux D, Salmon I: Leptomeningeal dissemination of low-grade intramedullary gliomas: about one case and review. Clin Neurol Neurosurg; 2009 May;111(4):390-4

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  • Here, we report a case of an intramedullary spinal cord low-grade glioma occurring in an adult presenting by LM dissemination.
  • Lumbar puncture showed low CSF glucose, high CSF protein and no tumor cells.
  • A spinal meningeal biopsy showed arachnoiditis with isolated atypical cells which were cytokeratin immunopositive.
  • A differential diagnosis was proposed between arachnoiditis close to an infectious process or close to meningeal carcinomatosis.
  • This case, like cases occurring in children, cannot easily be classified in the present WHO system of classification of CNS tumors.
  • [MeSH-major] Glioma / secondary. Meningeal Neoplasms / secondary. Spinal Cord Neoplasms / pathology

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  • (PMID = 19128871.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 24
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92. Mawrin C, Perry A: Pathological classification and molecular genetics of meningiomas. J Neurooncol; 2010 Sep;99(3):379-91
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  • Meningiomas are extremely common adult brain tumors originating from meningeal coverings of the brain and spinal cord.
  • While most are slowly growing Word Health organization (WHO) grade I tumors, rare variants (clear cell, chordoid, papillary, and rhabdoid), as well as brain invasive (WHO grade II), atypical (WHO grade II), and anaplastic (WHO grade III) meningiomas are considerably more aggressive.
  • In addition to alterations of CDKN2A, p14(ARF), and CDKN2B tumor suppressor genes on 9p21, a contribution of the wingless (wnt) pathway with alterations of the E-cadherin and beta-catenin proteins, as well as alterations of the hedgehog signaling pathway have been implicated in anaplastic meningiomas.
  • [MeSH-major] Meningeal Neoplasms / classification. Meningeal Neoplasms / genetics. Meningioma / classification. Meningioma / genetics

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  • (PMID = 20809251.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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93. Grujicić M, Vucković N, Vuleković P: [Morphological characteristics of meningiomas]. Med Pregl; 2010 Mar-Apr;63(3-4):237-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Meningiomas are common intracranial neoplasms which originate from the soft meninges, precisely from meningeal arachnoidal cells.
  • It included 490 consecutive patients of both sexes with diagnosed intracranial tumors and undergoing surgical treatment at the Neurosurgery Clinic of the Clinical Center of Vojvodina.
  • Out of 490 patients with diagnosed intracranial tumors, 137 (27.96%) were diagnosed to have meningiomas.
  • In regard to other histological types of intracranial tumors, meningiomas were more frequent in females (36.3%).
  • The tumor is located in the left frontal region.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 21053467.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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94. Tabernero MD, Maillo A, Gil-Bellosta CJ, Castrillo A, Sousa P, Merino M, Orfao A: Gene expression profiles of meningiomas are associated with tumor cytogenetics and patient outcome. Brain Pathol; 2009 Jul;19(3):409-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profiles of meningiomas are associated with tumor cytogenetics and patient outcome.
  • Cytogenetic analysis is a powerful tool for predicting recurrence in meningiomas, even among histologically benign/grade I tumors.
  • Despite this, no study has been reported in which the impact of tumor cytogenetics on the gene expression profiles (GEP) has been analyzed in meningiomas.
  • Here, we analyzed the GEP of 47 tumors and correlated them with the most clinical relevant cytogenetic subgroups of meningiomas, as confirmed through the analysis of 172 patients.
  • Additionally three normal meningeal samples were also studied.
  • Overall, our results show a clear association between the clinically relevant cytogenetic subgroups of meningiomas including diploid tumors (n = 18), isolated -22/22q- (n = 12), del(1p36) alone (n = 4) and complex karyotypes associated with del(1p36) and/or -14q (n = 13) and their GEP.
  • Accordingly, based on the expression of 85 genes (40 of which were coded in the altered chromosomes used for patient stratification) the cytogenetic class of the tumor could be predicted with an error of <1%, a clear association being found between the GEP and patient outcome (P = 0.03) but not tumor histopathology.
  • [MeSH-major] Cytogenetic Analysis. Gene Expression Profiling. Meningeal Neoplasms / genetics. Meningioma / genetics. Neoplasm Recurrence, Local / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Treatment Outcome. Young Adult

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  • (PMID = 18637901.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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95. Asanuma K, Kasai Y, Takegami K, Ito H, Yoshikawa T, Uchida A: Spinal neurocutaneous melanosis without cutaneous nevi. Spine (Phila Pa 1976); 2008 Oct 1;33(21):E798-801
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY OF BACKGROUND DATA: Neurocutaneous melanosis is a rare congenital syndrome consisting of benign or malignant melanocytic tumors of the central nervous system and cutaneous nevi.
  • In general, patients are treated with palliative therapy, such as shunt placement to reduce intracranial pressure or tumor resection to reduce compression of the brain or spine.
  • Magnetic resonance imaging (MRI) of the spine revealed intradural tumor at the T5 level.
  • Computed tomography myelography showed intradural extramedullary tumor.
  • After the pigmented dura was opened, a pigmented tumor was resected.
  • RESULTS: Histologically, the pigmented tumor represented low grade.
  • The pigmented dura and bone comprised melanin-bearing cells without tumor cells.
  • Meningeal melanocytoma with leptomeningeal melanosis in the absence of cutaneous nevi was diagnosed.
  • CONCLUSION: This patient displayed spinal meningeal melanocytoma and leptomeningeal melanosis without cutaneous nevi.
  • [MeSH-major] Melanosis / radiography. Meningeal Neoplasms / radiography. Neurocutaneous Syndromes / radiography
  • [MeSH-minor] Adult. Humans. Male. Nevus, Intradermal / radiography. Nevus, Intradermal / surgery. Skin Neoplasms / radiography. Skin Neoplasms / surgery

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  • (PMID = 18827686.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Martin AJ, Cha S, Higashida RT, Cullen SP, Halbach V, Dowd CF, McDermott MW, Saloner DA: Assessment of vasculature of meningiomas and the effects of embolization with intra-arterial MR perfusion imaging: a feasibility study. AJNR Am J Neuroradiol; 2007 Oct;28(9):1771-7
eScholarship, California Digital Library, University of California. Full text from University of California eScholarship .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Arterial supply to these tumors is typically identified by diffuse areas of parenchymal staining after selective x-ray angiograms.
  • MATERIALS AND METHODS: Selective intra-arterial (IA) injection of dilute MR contrast media was used to assess the vascular distribution territories of meningeal tumors before and after embolization therapy.
  • Regions of the tumor that experienced loss of signal intensity after localized contrast injections into the external and common carotid as well as vertebral arteries were used to quantify the specific vessel's volume of distribution.
  • Assessments were made before and after embolization to reveal changes in the vascular supply of the tumor.
  • MR findings were compared with radiographic evaluation of tumor vascular supply on the basis of conventional x-ray angiography.
  • In some instances, MR revealed postembolization residual enhancement of the tumor that was difficult to appreciate on x-ray angiograms.
  • Changes in tumor vasculature could be detected after embolization, which reveal the volumetric fraction of the tumor affected by the therapy.
  • [MeSH-major] Embolization, Therapeutic / methods. Magnetic Resonance Angiography / methods. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / therapy. Meningioma / diagnosis. Meningioma / therapy. Neovascularization, Pathologic / diagnosis
  • [MeSH-minor] Adult. Aged. Contrast Media / administration & dosage. Feasibility Studies. Female. Gadolinium DTPA / administration & dosage. Humans. Image Enhancement / methods. Injections, Intra-Arterial. Male. Middle Aged. Perfusion / methods. Reproducibility of Results. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 17885240.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 84F6U3J2R6 / gadodiamide; K2I13DR72L / Gadolinium DTPA
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97. Chacko G, Chacko AG, Rajshekhar V, Muliyil JP: Intracranial hemangiopericytomas: correlation of topoisomerase IIalpha expression with biologic behavior. Surg Neurol; 2006 Jan;65(1):11-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Meningeal hemangiopericytomas are aggressive tumors that have a high rate of recurrence despite gross total resection and radiation therapy.
  • Immunohistochemistry was performed on all the tumors using a monoclonal antibody to topoisomerase IIalpha, and the proliferation index was calculated.
  • A radical excision of tumor was done in 18, subtotal excision in 2, partial excision in 4, and a biopsy in 3 patients.
  • Tumor recurrence was noted in 15 (55.6%) of the 27 patients (mean follow-up duration, 51.5 months).
  • [MeSH-major] Antigens, Neoplasm / metabolism. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Meningeal Neoplasms / enzymology. Meningeal Neoplasms / pathology. Meningioma / enzymology. Meningioma / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / enzymology. Neoplasm Recurrence, Local / pathology. Predictive Value of Tests. Prognosis. Retrospective Studies

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  • (PMID = 16378841.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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98. Foreid H, Barroso C, Carvalho H, Morgado C, Roque L, Pimentel J: A 22-year-old man with intracraneal hypertension and impaired sensation over the perineum and left foot. Brain Pathol; 2009 Oct;19(4):735-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary leptomeningeal tumors are rare and can have multiple origins.
  • This young man presented an intracranial hypertension syndrome and brain MRI features of diffuse leptomeningeal enhancement over cerebral and cerebellar hemispheres.
  • A second cerebellar biopsy allowed the diagnosis of a primary diffuse leptomeningeal Primitive Neuroectodermal Tumor (PNET).
  • [MeSH-major] Cerebellum / pathology. Meningeal Neoplasms / diagnosis. Neuroectodermal Tumors, Primitive / diagnosis
  • [MeSH-minor] Apoptosis. Humans. Hydrocephalus / etiology. Hydrocephalus / therapy. Hypesthesia / etiology. Magnetic Resonance Imaging. Male. Treatment Outcome. Young Adult

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  • (PMID = 19744046.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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99. Johnson MD, Vito F, O'Connell MJ: Mesothelin expression in the leptomeninges and meningiomas. J Histochem Cytochem; 2008 Jun;56(6):579-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sections of 20 normal adult brains with leptomeninges and 49 World Health Organization (WHO) grade I, 21 grade II, and 2 grade III meningiomas were analyzed using an extensively characterized monoclonal antibody to mesothelin and streptavidin-biotin complex immunohistochemistry.
  • It was also detected in 7 of 21 WHO II tumors and 1 of the 2 anaplastic meningiomas.
  • Future studies may clarify its role in the development of meningiomas, meningeal seeding of gliomas, and metastases to the leptomeninges.
  • [MeSH-major] Arachnoid / metabolism. Membrane Glycoproteins / biosynthesis. Meningeal Neoplasms / metabolism. Meningioma / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. GPI-Linked Proteins. Humans. Male. Middle Aged

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  • (PMID = 18347077.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin
  • [Other-IDs] NLM/ PMC2386771
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100. Verbeke SL, Fletcher CD, Alberghini M, Daugaard S, Flanagan AM, Parratt T, Kroon HM, Hogendoorn PC, Bovée JV: A reappraisal of hemangiopericytoma of bone; analysis of cases reclassified as synovial sarcoma and solitary fibrous tumor of bone. Am J Surg Pathol; 2010 Jun;34(6):777-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A reappraisal of hemangiopericytoma of bone; analysis of cases reclassified as synovial sarcoma and solitary fibrous tumor of bone.
  • In soft tissue, it is accepted that most such lesions are solitary fibrous tumors (SFTs), monophasic synovial sarcomas (SSs), or myofibromatoses.
  • All tumors were located within bone, either sited within spine or extremities.
  • All tumors showed thin-walled branching vessels surrounded by undifferentiated spindle or round cells.
  • These cells showed variation in their morphologic pattern: 6 tumors showed a pattern-less architecture and varying cellularity, consistent with SFT; 3 of 5 cases examined were CD34-positive.
  • Three tumors showed more densely packed sheets and fascicles of poorly differentiated cells, resembling SS, of which 2 showed focal staining for keratin AE1/AE3 or epithelial membrane antigen.
  • Fluorescent in-situ hybridization confirmed the presence of SS18 rearrangement in 1 of 2 tumors examined.
  • [MeSH-major] Bone Neoplasms / pathology. Hemangiopericytoma / pathology. Sarcoma, Synovial / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Meningeal Neoplasms / genetics. Meningeal Neoplasms / metabolism. Meningeal Neoplasms / pathology. Middle Aged. Prognosis. Young Adult

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  • (PMID = 20421780.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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