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1. Santaella Y, Borrego I, López J, Ortiz MJ, Vázquez R: [18-FDG-PET in a case of recurrent malignant schwannoma]. Rev Esp Med Nucl; 2005 Mar-Apr;24(2):127-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [18-FDG-PET in a case of recurrent malignant schwannoma].
  • [Transliterated title] Diagnóstico de recurrencia mediante FDG-PET en un caso clínico de schwannoma maligno.
  • The peripheral nerve sarcoma, also called malignant schwannoma, is originally a soft tissue sarcoma.
  • It is mainly located in the peripheral sheath nerve of the limbs and usually infiltrates the nerve fibres.
  • We present the case of a thirty year old woman with a malignant schwannoma in her left leg sciatic nerve who had been treated on several occasions.
  • PET can be a useful technique to detect recurrence for this kind of tumor, mainly in patients who have been previously radiated when the MRI is insufficient to perform a differential diagnosis between postirradiation fibrosis and tumoral recurrence, allowing for suitable therapeutic management of the patient.
  • [MeSH-major] Fluorodeoxyglucose F18. Neurilemmoma / radionuclide imaging. Peripheral Nervous System Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Sciatic Neuropathy / radionuclide imaging
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 15745683.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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2. Joseph JA, Jaberoo MC, Sandison A, Grant WE: Benign schwannoma of the tonsil. BMJ Case Rep; 2010;2010
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign schwannoma of the tonsil.
  • Tonsillar schwannoma is a slow growing lesion presenting in the third to fifth decade of life.
  • Tonsillar schwannoma can be diagnosed in the outpatient clinic.
  • Schwannoma has the potential for malignant transformation, with no recorded cases of this occurring in the tonsil.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Dysphonia / diagnosis. Dysphonia / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Male. Rare Diseases. Risk Assessment. Tomography, X-Ray Computed / methods. Tonsillectomy / methods. Treatment Outcome. Young Adult

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  • (PMID = 22767561.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029798
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3. Stojanovic MP, Radojkovic M, Jeremic LM, Zlatic AV, Stanojevic GZ, Jovanovic MA, Kostov MS, Katic VP: Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection. World J Gastroenterol; 2010 Jan 7;16(1):119-22
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  • [Title] Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection.
  • Pancreatic schwannoma is a very uncommon tumor of the pancreas, with only 27 cases reported.
  • Most pancreatic schwannomas are benign, with only four malignant tumors reported.
  • We describe a case of giant malignant schwannoma of the pancreatic body and tail, which involved the transverse colon.
  • The tumor was treated successfully with en bloc distal splenopancreatectomy and colon resection.
  • This is believed to be the first reported radical operation for malignant schwannoma of the pancreatic body, with infiltration of the transverse colon, with excellent long-term results.
  • In the case of the benign tumors, local excision is adequate, but in the case of malignant schwannoma, oncological standards must be fulfilled.
  • [MeSH-major] Colectomy. Colon / surgery. Neurilemmoma / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Biopsy. Female. Humans. Lymph Node Excision. Neoplasm Invasiveness. Splenectomy. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20039458.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2799907
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4. Cho YJ, Won JB, Byeon SH, Yang WI, Koh HJ, Kwon OW, Lee SC: A choroidal schwannoma confirmed by surgical excision. Korean J Ophthalmol; 2009 Mar;23(1):49-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A choroidal schwannoma confirmed by surgical excision.
  • Schwannomas rarely present as intraocular tumors and are often misdiagnosed as malignant melanoma.
  • We describe a choroidal schwannoma confirmed by sclerouvectomy.
  • Histologically, the tumor was composed of a mixture of cellular solid components (Antoni A) and loose myxoid components (Antoni B).
  • The tumor was eventually diagnosed as a schwannoma.
  • In the case of atypical findings for a malignant melanoma, a benign neoplasm should be included in the differential diagnosis.
  • We are unaware of previous reports in which a choroidal schwannoma was diagnosed by surgical excision.
  • [MeSH-major] Choroid / pathology. Choroid Neoplasms / diagnosis. Eye Enucleation / methods. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19337481.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2655748
  • [Keywords] NOTNLM ; Enucleation / Schwannoma / Sclerouvectomy
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5. Habib T, Hamdi JT, Hussain W, Almiamini W, Hamdi K, Wani AM, Al Zeyani NR: Presacral schwannoma treated as irritable bowel syndrome. BMJ Case Rep; 2010;2010
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presacral schwannoma treated as irritable bowel syndrome.
  • Presacral tumours represent a heterogeneous group of predominantly benign and occasionally malignant neoplasms.
  • Schwannomas of the presacral region are one variant described as benign tumours of neurogenic origin.
  • The case of a large presacral schwannoma in a 26-year-old man, who was treated for irritable bowel syndrome for 4 years, is presented.
  • The tumour was resected and histology revealed it to be a schwannoma.
  • [MeSH-major] Delayed Diagnosis. Diagnostic Errors. Irritable Bowel Syndrome / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Constipation / etiology. Diagnosis, Differential. Humans. Male. Sacrococcygeal Region

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  • (PMID = 22791578.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Video-Audio Media
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3038043
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6. Demetriades AK, Saunders N, Rose P, Fisher C, Rowe J, Tranter R, Hardwidge C: Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery. Skull Base; 2010 Sep;20(5):381-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery.
  • Only a handful of cases of de-novo malignancies of the vestibulocochlear nerve have been reported.
  • Even rarer is the malignant transformation of a previously histologically diagnosed benign vestibular schwannoma.
  • We present the case of a young adult who had combined operative/Gamma knife treatment for a benign vestibular schwannoma, followed by further surgery 2 years later.
  • He represented 10 years after original diagnosis with facial numbness and ataxia, MRI showing gross tumor recurrence.
  • After radical resection, histology showed malignant transformation to a malignant peripheral nerve sheath tumor.
  • Histology confirmed further de-differentiation to an anaplastic sarcoma.
  • While awaiting radiotherapy the tumor recurred again, the patient succumbing.
  • In the literature there are 13 other cases of malignant vestibular schwannomata.
  • The tumor biology of vestibular schwannomata as well as the radiobiology in the context of malignant transformation is discussed.

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  • [Cites] Nucleic Acids Res. 1983 Oct 25;11(20):7191-203 [6634412.001]
  • (PMID = 21359005.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3023338
  • [Keywords] NOTNLM ; Gamma knife radiosurgery / Vestibular schwannoma / acoustic neuroma / anaplastic sarcoma / malignant peripheral nerve sheath tumor (MPNST) / malignant transformation / radiotherapy
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7. Chan PT, Tripathi S, Low SE, Robinson LQ: Case report--ancient schwannoma of the scrotum. BMC Urol; 2007;7:1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report--ancient schwannoma of the scrotum.
  • BACKGROUND: Scrotal schwannoma is a rare neoplasm and poses a diagnostic challenge to urologists.
  • This article describes a rare case of ancient scrotal schwannoma and reviews the current modality of investigation and treatment of this tumour.
  • Surgical excision was undertaken and histology was an ancient schwannoma of the scrotum.
  • CONCLUSION: Schwannoma is a benign encapsulating neoplasm with an overall low incidence, occurring mostly in the head and neck region and seldom in the scrotum.
  • Variations of schwannoma such as cellular, ancient, glandular and epithelioid are observed based on the appearances.
  • Ancient schwannoma exhibits pleomorphism without mitosis as the result of cellular degeneration, which can lead to an erroneous diagnosis of malignancy.
  • Malignant change is exceedingly rare.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Genital Neoplasms, Male / therapy. Neurilemmoma / diagnosis. Neurilemmoma / therapy
  • [MeSH-minor] Adult. Humans. Male. Scrotum

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  • (PMID = 17244372.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
  • [Other-IDs] NLM/ PMC1783662
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8. Di Giovannantonio L, Bellocci R, Zappacosta R, Zappacosta B, Castrataro A, Liberatore M, Liberati M, Angelucci D: [Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report]. Pathologica; 2005 Feb;97(1):7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report].
  • [Transliterated title] Schwannoma maligno primitivo della cervice uterina: un tumore maligno a comportamento inusuale. Caso clinico.
  • Malignant tumors of peripheral nerves (MPNST) represent approximately 5-10% of all soft tissue sarcomas and usually are in relationship with a major nerve.
  • Primary cervical malignant Schwannomas are very rare neural sheat tumors that, grossly and clinically, are misdiagnosed for other more frequent lesions of the uterine cervix.
  • We report a case of primary cervical malignant Schwannoma in a 27 years old female with atypical bleeding.
  • [MeSH-major] Neurilemmoma / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • [ErratumIn] Pathologica. 2005 Jun;97(3):159. Zappacosta, B [added]
  • (PMID = 15918410.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 9
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9. Oxner CR, Shinners MJ, Godin DA, Lyn IT, Brent RB, McFadden PM: Obstructing tracheobronchial schwannoma. J La State Med Soc; 2005 May-Jun;157(3):159-61
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  • [Title] Obstructing tracheobronchial schwannoma.
  • Endotracheal and endobronchial schwannomas are extremely rare tumors of neurogenic origin.
  • Two cases of tracheobronchial schwannoma with proximal airway obstruction are reported.
  • Because malignant transformation is exceedingly rare, operative resection of tracheobronchial schwannomas based on the principle of conservation of lung parenchyma is emphasized.
  • [MeSH-major] Airway Obstruction / etiology. Neurilemmoma / diagnosis. Tracheal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Bronchoscopy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16173316.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Halac M, Cnaral F, Sait S, Ylmaz S, Kerim S, Sergülen D, Uslu I: FDG PET/CT findings in recurrent malignant schwannoma. Clin Nucl Med; 2008 Mar;33(3):172-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG PET/CT findings in recurrent malignant schwannoma.
  • Malignant schwannoma is an uncommon but aggressive sarcoma that most commonly arises in young and middle-aged adults.
  • We present a 28-year-old male patient with a recurrent chest wall malignant schwannoma.
  • We conclude that FDG PET/CT could play an important role in the staging, restaging, and post-therapy follow-up of malignant schwannomas.
  • [MeSH-major] Fluorodeoxyglucose F18. Muscle Neoplasms / radiography. Muscle Neoplasms / radionuclide imaging. Neurilemmoma / radiography. Neurilemmoma / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Thoracic Wall / radiography. Thoracic Wall / radionuclide imaging. Tomography, Emission-Computed
  • [MeSH-minor] Adult. Axilla / radiography. Axilla / radionuclide imaging. Humans. Male. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging

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  • (PMID = 18287838.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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11. Manganoni AM, Farisoglio C, Lonati A, Zorzi F, Tucci G, Pinton PG: Cutaneous epithelioid malignant schwannoma: review of the literature and case report. J Plast Reconstr Aesthet Surg; 2009 Sep;62(9):e318-21
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  • [Title] Cutaneous epithelioid malignant schwannoma: review of the literature and case report.
  • A case of malignant epithelioid schwannoma in the skin is reported.
  • This was a rare variant of a malignant tumour that arose on the back of a 35-year-old male without neurofibromatosis.
  • Ultrastructural and immunohistochemical features of the lesion were consistent with those of malignant epithelioid schwannoma so a radical excision was performed.
  • Most ordinary malignant schwannoma are located in the deep soft tissue of the proximal portions of the upper and lower extremities and trunk; to the best of our knowledge only 26 cases of malignant epithelioid schwannoma in the skin and subcutis have been described in the literature.
  • We can conclude that malignant epithelioid schwannoma in the skin and subcutis is eminently curable if treated with wide local excision.
  • [MeSH-major] Epithelioid Cells / pathology. Neurilemmoma / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Treatment Outcome

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  • (PMID = 18455973.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 11
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12. Gelly-Marty M, Martin E, Assous D, Cuisenier J, Collin F: [Plexiform schwannoma of the delto-pectoral area]. Ann Pathol; 2007 Apr;27(2):133-5
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  • [Title] [Plexiform schwannoma of the delto-pectoral area].
  • Plexiform schwannoma is a form of schwannoma which usually involves cutaneous tissues.
  • It cannot be easily differentiated from malignant tumors, especially deep or cellular lesions.
  • We report a deep plexiform schwannoma which we place among the various benign or malignant nerve sheath tumors, which may or may not develop within the context of genetic disease.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology. Thoracic Wall
  • [MeSH-minor] Humans. Male. Young Adult

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  • (PMID = 17909473.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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13. Chibbaro S, Herman P, Povlika M, George B: Malignant trigeminal schwannoma extending into the anterior skull base. Acta Neurochir (Wien); 2008 Jun;150(6):599-604
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant trigeminal schwannoma extending into the anterior skull base.
  • Malignant schwannomas are rare tumours that seldom grow in the head and neck and their occurrence is even rarer in patients not affected by neurofibromatosis.
  • The authors report a 40 year old woman with a left trigeminal malignant schwannoma (arising from V2), involving the infratemporal fossa and subsequently extending into the maxillary, sphenoid and ethmoidal sinuses, the orbit, and the intracranial compartment.
  • [MeSH-major] Cranial Fossa, Anterior / surgery. Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Trigeminal Nerve Diseases / surgery
  • [MeSH-minor] Adult. Biopsy. Cooperative Behavior. Disease Progression. Dose Fractionation. Female. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoadjuvant Therapy. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Palliative Care. Patient Care Team. Radiotherapy, Adjuvant

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  • (PMID = 18473115.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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14. Li Q, Gao C, Juzi JT, Hao X: Analysis of 82 cases of retroperitoneal schwannoma. ANZ J Surg; 2007 Apr;77(4):237-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of 82 cases of retroperitoneal schwannoma.
  • BACKGROUND: The aim of the study was to improve the diagnosis and treatment of retroperitoneal schwannoma by analysing clinical manifestations and postoperative course of this rare disease.
  • METHODS: A retrospective analysis of 82 patients with retroperitoneal schwannoma between January 1951 and September 2004 was carried out.
  • Pathological results showed 81 (98.8%) were benign schwannoma and 1 (1.2%) was a malignant one.
  • One benign schwannoma recurred 3 years after the operation.
  • The patient with malignant schwannoma died 18 months after the operation because of metastasized disease.
  • Malignant schwannomas are insensitive to chemotherapy and radiation, resulting in poor prognosis.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / surgery. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnostic Imaging. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17388825.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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15. Marton E, Feletti A, Orvieto E, Longatti P: Dumbbell-shaped C-2 psammomatous melanotic malignant schwannoma. Case report and review of the literature. J Neurosurg Spine; 2007 Jun;6(6):591-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dumbbell-shaped C-2 psammomatous melanotic malignant schwannoma. Case report and review of the literature.
  • The authors present the case of a dumbbell-shaped malignant psammomatous melanotic schwannoma of the upper cervical spine involving the C-2 sensory root.
  • The family of the patient had a history of other malignant stromal tumors, without the Carney complex genetic pattern.
  • Histopathological examination of the lesion revealed it to be a malignant psammomatous melanotic schwannoma.
  • The cerebrospinal MR image of the patient obtained at the 12-month follow-up examination demonstrated the presence of tumor progression into the subarachnoid space at the C-3 level.
  • The strong malignancy potential of the lesion must be considered in the future management of the patient, especially due to the presence in the family of other stromal tumors such as gastrointestinal-stromal tumors and malignant melanomas.
  • The authors review all the literature concerning melanotic schwannomas and report 105 cases of melanotic schwannoma that were not related to the Carney complex.
  • The particular focus of their review is on the characteristics of the malignant progression of melanotic schwannoma, such as local recurrences, metastasis, and survival rate.
  • [MeSH-major] Cervical Vertebrae. Neurilemmoma / diagnosis. Spinal Neoplasms / diagnosis. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neurosurgical Procedures

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  • (PMID = 17561752.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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16. Chetty R, Vajpeyi R, Penwick JL: Psammomatous melanotic schwannoma presenting as colonic polyps. Virchows Arch; 2007 Sep;451(3):717-20
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  • [Title] Psammomatous melanotic schwannoma presenting as colonic polyps.
  • Psammomatous melanotic schwannoma is an uncommon neoplasm that usually occurs in the setting of Carney's complex.
  • The tumor was diffusely positive for S-100, and focally for HMB-45 and melan-A.
  • The differential diagnosis includes melanoma, GIST, pigmented neuroendocrine tumor, and epithelioid leiomyoma.
  • The lack of malignant features separates this lesion from melanoma while the immunophenotype of the other lesions is characteristic.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Colonoscopy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Immunophenotyping. Leiomyoma, Epithelioid. Melanins / analysis. Melanoma. Neuroendocrine Tumors. Pigmentation

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  • (PMID = 17622556.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Melanins
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17. Schmitz KJ, Unkel C, Grabellus F, Baba HA, Dirsch O, Neumann A: Melanotic schwannoma of the neck mimicking a malignant melanoma. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic schwannoma of the neck mimicking a malignant melanoma.
  • A fine-needle aspiration biopsy performed elsewhere led to the diagnosis of malignant melanoma.
  • Diagnostic exstirpation of the cervical tumor resulted in the intraoperative diagnosis of a malignant melanoma.
  • Subsequent pathological examination including ultrastructural analysis allowed the revision of the diagnosis to that of melanotic schwannoma, a rare, pigmented nerve sheath tumor.
  • With regard to prognostic and therapeutic issues, it is necessary to differentiate these tumors from the more common metastatic malignant melanoma.
  • [MeSH-major] Melanoma / diagnosis. Neurilemmoma / pathology. Pharyngeal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • (PMID = 15133690.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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18. Gonzalez LF, Lekovic GP, Eschbacher J, Coons S, Spetzler RF: A true malignant schwannoma of the eighth cranial nerve: case report. Neurosurgery; 2007 Aug;61(2):E421-2; discussion E422
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A true malignant schwannoma of the eighth cranial nerve: case report.
  • OBJECTIVE: The clinical presentation, pathology, treatment, and outcome of a 43-year-old woman with a malignant peripheral nerve sheath tumor arising from a benign schwannoma of the eighth cranial nerve are presented.
  • CLINICAL PRESENTATION: Initially, the tumor was debulked.
  • After finding malignant areas within the benign tumor, it was considered to be a malignant transformation of a previously benign tumor.
  • Postoperatively, the tumor bed was radiated for palliation.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Neuroma, Acoustic / secondary. Vestibulocochlear Nerve / pathology
  • [MeSH-minor] Adult. Dura Mater / pathology. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Meningeal Neoplasms / secondary

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  • (PMID = 17762727.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Wenzel GI, Götz F, Lenarz T, Stöver T: HIV-associated cerebral lymphocyte infiltration mimicking vestibular schwannoma. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1567-71
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  • [Title] HIV-associated cerebral lymphocyte infiltration mimicking vestibular schwannoma.
  • The association of unilateral, rapidly progressive hearing loss, tinnitus and vestibular dysfunction in combination with a contrast-enhancing mass within the internal auditory canal on MRI is suggestive of a vestibular schwannoma (VS).
  • We report the rare finding of a HIV-associated cerebral lymphocyte infiltration, most probably malignant lymphoma, which was presumed initially to be a vs. A 36-year-old male presented with progressive unilateral hearing loss accompanied by acute, ipsilateral tinnitus.
  • Unilateral, rapidly progressive hearing loss and a fast growing cerebello-pontine mass is atypical for VS and highly suspicious of malignant disease.
  • [MeSH-minor] Adult. Facial Paralysis / etiology. Fatal Outcome. Humans. Lymphocytes / immunology. Male

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  • (PMID = 18317791.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Kellogg A, Watson WJ: Malignant schwannoma in pregnancy: a case report and literature review. Am J Perinatol; 2010 Mar;27(3):201-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant schwannoma in pregnancy: a case report and literature review.
  • Malignant peripheral nerve sheath tumors in pregnancy are an uncommon finding.
  • Evaluation revealed a large chest mass, biopsy proven to be a malignant schwannoma.
  • This malignant peripheral nerve sheath tumor, discovered at 26 weeks' gestation, grew so rapidly that delivery was necessary at 30 weeks' gestation.
  • [MeSH-major] Lung Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neurilemmoma / pathology. Neurofibromatosis 1 / diagnosis. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / secondary. Cesarean Section. Fatal Outcome. Female. Humans. Lymphatic Metastasis. Pregnancy. Pregnancy Outcome. Prenatal Care / methods

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 19688672.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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21. Sengöz A, Taşdemiroğlu E, Togay H: Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report. Neurosurg Focus; 2006;21(6):E11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report.
  • The authors present a case of clear cell sarcoma (CCS) in which the tumor originated in the S-1 nerve root and had been previously diagnosed as psammomatous melanotic schwannoma (PMS).
  • This is the third case of a spinal nerve root origin for CCS reported in the English-language literature.
  • The similar histogenesis of CCS and malignant melanoma supports the hypothesis that biological agents or immunotherapy are potentially important areas of investigation.
  • The border of the resection was extended 1 cm distal to the tumor margin.
  • The new histopathological diagnosis was CCS (malignant melanoma of soft tissue).
  • A CCS originating from peripheral nerves is quite rare.
  • [MeSH-major] Neurilemmoma / classification. Peripheral Nervous System Neoplasms / classification. Sarcoma, Clear Cell / classification. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm. Biomarkers, Tumor / analysis. Breast Neoplasms. Diagnosis, Differential. Diagnostic Errors. Female. Fibroadenoma. Humans. Keratins / analysis. Male. Melanins / analysis. Melanoma-Specific Antigens. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local. Neoplasms, Multiple Primary. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / genetics. Nerve Sheath Neoplasms / pathology. Pigmentation Disorders / diagnosis. Pigmentation Disorders / genetics. Prognosis. S100 Proteins / analysis. Sacrococcygeal Region. Syndrome. Vimentin / analysis

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  • (PMID = 17341045.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanins; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 17
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22. Mey KH, Buchwald C, Daugaard S, Prause JU: Sinonasal schwannoma--a clinicopathological analysis of five rare cases. Rhinology; 2006 Mar;44(1):46-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sinonasal schwannoma--a clinicopathological analysis of five rare cases.
  • Schwannoma of the nasal cavity or the sinuses is a rare condition.
  • Four cases were benign; however, one case of melanotic schwannoma, exhibited malignant transformation.
  • All tumours were treated surgically; only the malignant case received adjuvant radiotherapy.
  • The benign cases have so far shown good prognosis without recurrences; however, in the case of the melanotic schwannoma a fatal malignant transformation was seen 13 years after initial diagnosis.
  • [MeSH-major] Neurilemmoma / pathology. Nose Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Adult. Aged, 80 and over. Female. Humans. Male. Middle Aged

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  • (PMID = 16550950.001).
  • [ISSN] 0300-0729
  • [Journal-full-title] Rhinology
  • [ISO-abbreviation] Rhinology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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23. Khouni H, Andrianne R, Nidhal H, Badreddine S, de Leval J, Faouzi MA: [Benign schwannoma, a rare retroperitoneal tumour]. Prog Urol; 2005 Feb;15(1):78-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign schwannoma, a rare retroperitoneal tumour].
  • Among retroperitoneal tumours derived from nervous tissue, schwannoma is defined as a tumour arising from neurilemma or Schwann nerve sheath cells.
  • Its diagnosis is immunohistological, and treatment is surgical, consisting of complete resection of the mass due to the risk of malignant degeneration.
  • The immunological and histological study concluded on benign schwannoma.
  • With a postoperative follow-up of two years, the patient has not presented any recurrence of this retroperitoneal schwannoma.
  • [MeSH-major] Neurilemmoma. Retroperitoneal Neoplasms
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 15822399.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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24. Zhang HY, Yang GH, Chen HJ, Wei B, Ke Q, Guo H, Ye L, Bu H, Yang K, Zhang YH: Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J (Engl); 2005 Sep 5;118(17):1451-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma.
  • BACKGROUND: Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • We investigated the clinicopathologic features, immunophenotypes, and ultrastructural features of 13 patients with nonpsammomatous melanotic schwannoma (NPMS).
  • METHODS: Tumor specimens of each patient were sectioned and stained with hematoxylin-eosin, Fontana-Masson, Prussian blue, and periodic acid-Schiff (PAS).
  • The tumor sites included the spinal nerve root (5 patients), cranial nerve (1), greater omentum (1), subcutaneous tissue (3), mesentery (1), bone (1) and mediastinum (1).
  • One patient (9.1%) with a primary tumor in the greater omentum developed another primary tumor of the same type in the subcutaneous tissue of the abdominal wall after the first operation.
  • Local recurrence of the tumor was seen in 2 patients (18.2%).
  • The tumor was composed of spindled and epithelioid cells with abundant intracytoplasmic melanin pigments.
  • Ultrastructurally, numerous elongated tumor-cell processes, duplicated basement membrane and melanosomes were observed in all developmental stages.
  • CONCLUSIONS: Histologically, melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • Distinguishing between this tumor and malignant melanoma is of paramount importance in planning of management.
  • Immunohistochemically, combined use of laminin and collagen IV is valuable in distinguishing melanotic schwannoma from malignant melanoma.
  • Further studies including cytogenetic or molecular biology are still required to better delineate melanotic schwannoma from malignant melanoma.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Prognosis

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  • (PMID = 16157048.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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25. Tahir MZ, Fatimi SH, Enam SA: Ancient schwannoma presenting as a thoracic mass. Surg Neurol; 2007 Nov;68(5):534-6
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  • [Title] Ancient schwannoma presenting as a thoracic mass.
  • BACKGROUND: Ancient schwannoma is a rare variant of schwannoma, histologically showing atypical features that may result in erroneous diagnosis of a malignant tumor.
  • CASE DESCRIPTION: We report a case of a 34-year-old man who was found to have giant mediastinal tumor.
  • He underwent thoracotomy to remove the mass, which was proven to be ancient schwannoma on histopathology.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17765953.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. De Waele M, Carp L, Lauwers P, Hendriks J, De Maeseneer M, Van Schil P, Blockx P: Paravertebral schwannoma with high uptake of fluorodeoxyglucose on positron emission tomography. Acta Chir Belg; 2005 Sep-Oct;105(5):537-8
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  • [Title] Paravertebral schwannoma with high uptake of fluorodeoxyglucose on positron emission tomography.
  • CT, MRI and fine needle aspiration cytology (FNAC) pointed in the direction of a benign mass, but positron emission tomography (PET) showed a high uptake of [(18)F]fluorodeoxyglucose (FDG), which was indicative of a malignant lesion.
  • Pathological analysis of the thoracoscopically resected tumour gave us the final diagnosis of a benign schwannoma.
  • This report demonstrates that a high uptake of FDG in a non-malignant mediastinal tumour is possible.
  • [MeSH-major] Neurilemmoma / radionuclide imaging. Spinal Neoplasms / radionuclide imaging
  • [MeSH-minor] Adult. Female. Fluorodeoxyglucose F18. Humans. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 16315843.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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27. Santos PP, Freitas VS, Pinto LP, Freitas Rde A, de Souza LB: Clinicopathologic analysis of 7 cases of oral schwannoma and review of the literature. Ann Diagn Pathol; 2010 Aug;14(4):235-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic analysis of 7 cases of oral schwannoma and review of the literature.
  • The growth of these tumors causes displacement and compression of the nerve of origin.
  • Anti-S100 protein is the most widely used antibody for the identification of this neoplasm.
  • Surgical excision is the treatment of choice for schwannomas, with few and controversial reports of recurrence or malignant transformation.
  • The present article reports 7 additional cases of oral schwannoma, and the literature is reviewed regarding clinicopathologic features, immunohistochemical findings, differential diagnosis, and therapeutic management of this benign neural tumor.
  • [MeSH-major] Mouth Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Middle Aged. Young Adult

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  • [Copyright] Crown Copyright 2010. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20637426.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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28. Gudena V, Verma N, Post G, Kizziah M, Fenning R, Montero AJ: Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review. Cancer Biol Ther; 2008 Jun;7(6):810-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review.
  • Malignant schwannomas or malignant peripheral nerve sheath tumors (MPNST) represent approximately 10% of all soft tissue sarcomas.
  • Metastatic disease from chest wall MPNST is very rare.
  • We present a case of a major clinical response to the tyrosine kinase inhibitor (TKI) sorafenib in a patient with metastatic MPNST.
  • A 42-year-old female with a prior history of neurofibromas developed MPNST, which later metastasized to the lungs and brain.
  • MPNST show high levels of Ras activity and hence these tumors are promising targets for TKIs.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzenesulfonates / therapeutic use. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / drug therapy. Neurilemmoma / diagnosis. Neurilemmoma / drug therapy. Pyridines / therapeutic use. Thoracic Wall / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / drug therapy. Brain Neoplasms / secondary. Female. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Neoplasm Metastasis. Niacinamide / analogs & derivatives. Phenylurea Compounds. Protein Kinase Inhibitors / therapeutic use. Radiography, Thoracic. Treatment Outcome

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  • (PMID = 18376142.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Protein Kinase Inhibitors; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
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29. Ndiaye M, Rouleau V, Rame JP, Pescatori P, Denoux Y, Louis MY, De Raucourt D: [Laryngeal schwannoma: a case report and review of the literature]. Rev Laryngol Otol Rhinol (Bord); 2006;127(4):243-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laryngeal schwannoma: a case report and review of the literature].
  • OBJECTIVES: In presenting a case of laryngeal schwannoma, the authors emphasize the difficulties in diagnosing this rare pathology and review treatment options.
  • MATERIALS AND METHOD: The authors present a case of laryngeal schwannoma in a 29 year old man, revealed by exertional inspiratory dyspnea.
  • The possibility of malignant change and recurrence warrant long-term follow-up.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Dyspnea / etiology. Humans. Laryngectomy. Male

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  • (PMID = 17315789.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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30. Agarwal K, Agarwal C, Agarwal M, Harbhajanka A: Plexiform schwannoma of scalp: a case report with brief review of literature. Indian J Pathol Microbiol; 2007 Oct;50(4):797-9
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  • [Title] Plexiform schwannoma of scalp: a case report with brief review of literature.
  • Plexiform schwannoma is a morphologically distinct and rare variant of schwannoma.
  • It is a benign tumor and malignant transformation has not been reported.
  • We are presenting a case of plexiform schwannoma occurring on scalp and measuring 8cm in size because of its rarity and unusual size.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / pathology. Scalp / pathology
  • [MeSH-minor] Adult. Biopsy. Humans. Male

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  • (PMID = 18306559.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 15
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31. Braunschweig F, Kramer MF, Assmann G, Arbogast S, Leunig A: [Schwannoma of the nasal cavity: a case report]. HNO; 2007 Dec;55(13):1013-6
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  • [Title] [Schwannoma of the nasal cavity: a case report].
  • It is very important to distinguish between schwannoma and primary benign neurofibroma.
  • Neurofibromas are lesions having the possibility for malignant transformation and recurrence.
  • A case of schwannoma in the nasal cavity is reported, and the diagnostic and therapeutic procedures, as well as recommendations from the literature, are described.
  • The histological and immunohistochemical features are discussed in detail to draw a distinction between schwannoma and neurofibroma.
  • In cases of intranasal and paranasal lesions, the existence of a schwannoma must be considered.
  • Differentiating between schwannoma and neurofibroma is important for estimating the risk of malignant transformation and recurrence.
  • [MeSH-major] Nasal Cavity / pathology. Neurilemmoma / pathology. Neurofibroma / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17874054.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 22
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32. Chiofalo MG, Longo F, Marone U, Franco R, Petrillo A, Pezzullo L: Cervical vagal schwannoma. A case report. Acta Otorhinolaryngol Ital; 2009 Feb;29(1):33-5
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  • [Title] Cervical vagal schwannoma. A case report.
  • Schwannoma originating from the cervical vagus nerve is an extremely rare neoplasm.
  • Vagal nerve schwannoma usually occurs between the third and fifth decades of life, it does not show sex predilection both sexes being equally affected and it most often presents as a painless, slow-growing, lateral neck mass.
  • A case of a cervical vagal schwannoma, in a 33-year old male with a previous medical history of malignant lymphoma, is described.
  • The clinical features, diagnosis, management and pathological findings of cervical vagal schwannoma are discussed.
  • [MeSH-major] Cranial Nerve Neoplasms. Neurilemmoma. Vagus Nerve Diseases
  • [MeSH-minor] Adult. Humans. Male

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  • [Cites] J Laryngol Otol. 2000 Feb;114(2):119-24 [10748827.001]
  • [Cites] Neurosurgery. 2000 Jun;46(6):1498-503 [10834653.001]
  • [Cites] Otolaryngol Head Neck Surg. 2000 Sep;123(3):334-6 [10964317.001]
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  • [Cites] Arch Otolaryngol Head Neck Surg. 2007 Jul;133(7):662-7 [17638778.001]
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  • [Cites] Head Neck. 1991 Sep-Oct;13(5):439-41 [1938363.001]
  • [Cites] Laryngoscope. 1996 Dec;106(12 Pt 1):1548-52 [8948621.001]
  • [Cites] Laryngoscope. 1984 Jul;94(7):946-9 [6738275.001]
  • (PMID = 19609380.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2689565
  • [Keywords] NOTNLM ; Benign tumours / Magnetic Resonance imaging / Schwannoma / Vagus nerve
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33. Bäck L, Heikkilä T, Passador-Santos F, Saat R, Leivo I, Mäkitie AA: Management of facial nerve schwannoma: A single institution experience. Acta Otolaryngol; 2010 Oct;130(10):1193-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of facial nerve schwannoma: A single institution experience.
  • CONCLUSION: Difficulties in diagnosis, conservative initial steps in the management algorithm and intraoperative risks for facial nerve (FN) injury are divisive features for this tumour entity.
  • One patient is currently under conservative follow-up for a parotid schwannoma (diagnosed with magnetic resonance imaging) with intact FN function.
  • No malignant schwannomas were encountered.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Facial Nerve. Neurilemmoma / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20441526.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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34. Lee CC, Yen YS, Pan DH, Chung WY, Wu HM, Guo WY, Chen MT, Liu KD, Shih YH: Delayed microsurgery for vestibular schwannoma after gamma knife radiosurgery. J Neurooncol; 2010 Jun;98(2):203-12
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  • [Title] Delayed microsurgery for vestibular schwannoma after gamma knife radiosurgery.
  • However, on rare occasions, some cases have needed traditional microsurgery to remove the tumor several months or years after radiosurgery.
  • The mean size of the tumor during GKS was 10.4 ml (range 2.3-23.5 ml).
  • The indications of microsurgery included adverse radiation effect with peri-focal edema, tumor enlargement, and cyst enlargement.
  • Although the perifocal edema could lead to more difficulty in surgery than in typically performed operations for schwannoma, subtotal resection was achieved in all patients.
  • The histology showed benign tumor in five patients, malignant peripheral nerve sheath tumor in one, and necrotic tissue in one.
  • [MeSH-minor] Adult. Aged. Female. Humans. Image Processing, Computer-Assisted / methods. Ki-67 Antigen / metabolism. Longitudinal Studies. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. S100 Proteins / metabolism. Severity of Illness Index. Time Factors. Treatment Outcome

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  • (PMID = 20405307.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / S100 Proteins
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35. Yeh CJ, Chuang WY, Huang ST, Jung SM: Schwannoma of the penis: a report of two cases. Chang Gung Med J; 2007 Nov-Dec;30(6):555-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannoma of the penis: a report of two cases.
  • Schwannomas are benign nerve sheath tumors, which can occur sporadically or in patients with neurofibromatosis.
  • The first patient was a 26-year-old man presenting with a 2 x 2 cm, slowly growing, painless tumor on the dorsal penile shaft.
  • Both patients received simple tumor excision, and neither experienced tumor recurrence.
  • Notably, multiple tumors are present in 30% of penile schwannoma cases, whereas most schwannomas at other locations present as a single tumor.
  • No reported patients had malignant transformation, but two had tumor recurrence 4 months and 7 years after excision.
  • [MeSH-major] Neurilemmoma / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 18350739.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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36. Azarpira N, Torabineghad S, Sepidbakht S, Rakei M, Bagheri MH: Cytologic findings in pigmented melanotic schwannoma: a case report. Acta Cytol; 2009 Jan-Feb;53(1):113-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic findings in pigmented melanotic schwannoma: a case report.
  • BACKGROUND: Psammomatous melanotic schwannoma (PMS) is a rare pigmented neural tumor most commonly occurring in the paraspinal region.
  • This rare tumor can cause diagnostic difficulties in imprint cytology due to cellular details masked by heavy melanin pigments.
  • Radiologic studies showed a 3.5-cm epidural mass in the region of the left L2 nerve root.
  • Imprint smears from the biopsied tissue fragment revealed mainly epithelioid cells with prominent nucleoli and variable amounts of cytoplasmic brown pigment, indicating a pigmented tumor with neuronal origin PMS, which was confirmed by histologic and immunohistochemical studies of the resected tumor.
  • CONCLUSION: PMS is a rare entity, and it is important to differentiate PMS from other pigmented tumors in the spinal canal, such as melanocytoma and malignant melanoma.
  • [MeSH-major] Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Melanins. Pigmentation

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  • (PMID = 19248566.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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37. Subhashraj K, Balanand S, Pajaniammalle S: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal; 2009 Jan;14(1):E12-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ancient schwannoma arising from mental nerve. A case report and review.
  • Schwannoma is an intraoral rare, benign neoplasm derived from the nerve sheath of peripheral nerves.
  • "Ancient schwannoma" shows histopathological features, such as degenerative changes and atypical nuclei, and may easily be confused with malignant neoplasms.
  • Ancient schwannoma of the head and neck region is relatively uncommon and very few cases had been reported in the oral cavity.
  • We present a case of ancient schwannoma arising from the mental nerve in a 19 year old male which was of eight months duration.
  • Ultrasonography showed that the tumor was closely associated with the mental nerve on the left side, suggestive of a peripheral neural sheath tumor.
  • Complete excision of the lesion was done under local anesthesia, preserving the mental nerve.
  • The histological picture was strongly suggestive of ancient schwannoma (Antoni A type).
  • [MeSH-major] Chin / innervation. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Young Adult

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  • (PMID = 19114949.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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38. Kaehler KC, Russo PA, Katenkamp D, Kreusch T, Neuber K, Schwarz T, Hauschild A: Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature. Melanoma Res; 2008 Dec;18(6):438-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature.
  • Melanocytic schwannoma is a rare soft-tissue tumor, which arises most commonly in the paraspinal sympathetic chain.
  • To date, only 17 cases of a cutaneous and subcutaneous melanocytic schwannoma have been reported.
  • Three cases of cutaneous melanocytic schwannoma, diagnosed in our institution are reported.
  • For further literature overview we performed a search on Medline using the terms 'melanocytic schwannoma' or 'melanotic schwannoma' or 'Carney complex' combined with 'skin' or 'cutaneous', for the period 1970-2007.
  • Seventeen patients were described to have melanocytic schwannoma of the skin or subcutaneous tissues.
  • In contrast, none of the reported cases of cutaneous or subcutaneous melanocytic schwannomas was characterized by a malignant course.
  • The differential diagnosis, especially with regard to malignant melanoma, is made by histology and by its clinical course, which differs from melanoma in its tendency to recur at the site of excision and slow rate of growth.
  • Commonly misdiagnosed as melanoma, this tumor reveals insights into the origin of both melanocytes and Schwann cells.
  • It is likely that the biological bases for melanoma and melanocytic schwannoma differ.
  • It is necessary to differentiate this tumor from melanoma because of the differing prognosis and the association of melanocytic schwannoma with the Carney complex.
  • [MeSH-major] Melanoma / diagnosis. Neurilemmoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Subcutaneous Tissue / pathology

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  • (PMID = 19011514.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 28
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39. Ying YL, Zimmer LA, Myers EN: Base of tongue schwannoma: a case report. Laryngoscope; 2006 Jul;116(7):1284-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Base of tongue schwannoma: a case report.
  • Both malignant and benign lesions may be found on the base of the tongue, including metastasis from other sites.
  • Here, we report a case of a 26-year-old woman with a schwannoma in the base of tongue removed through a suprahyoid pharyngotomy approach.
  • The biology and pathology of schwannoma in the oral cavity are discussed.
  • [MeSH-major] Neurilemmoma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging

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  • (PMID = 16826078.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Hamada K, Ueda T, Higuchi I, Inoue A, Tamai N, Myoi A, Tomita Y, Aozasa K, Yoshikawa H, Hatazawa J: Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging. Skeletal Radiol; 2005 Jan;34(1):52-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging.
  • We present two cases of peripheral nerve schwannoma which showed an increased accumulation of 2-deoxy-[(18)F] fluoro-D-glucose (FDG) in the tumors on positron emission tomography (PET) imaging acquired at both 1 h (early phase) and 2 h (delayed phase) after FDG injection.
  • We set the maximum standardized uptake value (SUV max) with a cut-off point of 3.0 to distinguish benign and malignant lesions.
  • Although the mechanism responsible for the increased FDG uptake in benign schwannomas remains unknown, we discuss our findings in the context of tumor cellularity and briefly review other studies on the subject.
  • [MeSH-major] Fluorodeoxyglucose F18. Neurilemmoma / radionuclide imaging. Peripheral Nervous System Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Radiopharmaceuticals
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Head and Neck Neoplasms / radionuclide imaging. Humans. Muscle Neoplasms / radionuclide imaging. Retroperitoneal Neoplasms / radionuclide imaging

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  • (PMID = 15480645.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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41. Inokuchi T, Takiuchi H, Moriwaki Y, Ka T, Takahashi S, Tsutsumi Z, Shima H, Hirota S, Yamamoto T: Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings. Magn Reson Imaging; 2006 Dec;24(10):1389-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings.
  • A laparoscopic adrenalectomy was performed under the suspicion of a malignant tumor, such as a malignant fibrous histiocytoma.
  • Pathologic findings indicated a retroperitoneal ancient schwannoma of two histologic types: Antoni A and Antoni B.
  • We considered that elucidation of the characteristic features of a schwannoma would provide helpful preoperative information for diagnosis.
  • [MeSH-major] Magnetic Resonance Imaging. Neurilemmoma / pathology. Retroperitoneal Neoplasms / pathology. Tomography, X-Ray Computed
  • [MeSH-minor] Abdomen / ultrasonography. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radiography. Adrenal Gland Neoplasms / ultrasonography. Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17145411.001).
  • [ISSN] 0730-725X
  • [Journal-full-title] Magnetic resonance imaging
  • [ISO-abbreviation] Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E: Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature. J Cutan Pathol; 2010 Sep;37(9):997-1001
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
  • Neuroblastoma-like schwannoma was first described by Goldblum et al. in 1994, and very few cases have since been reported.
  • It is a benign sporadic neoplasm with no reported association with neurofibromatosis, and is characterized histologically by small round lesional cells surrounding collagenous cores forming rosette-like structures.
  • The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Neuroblastoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Treatment Outcome

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  • (PMID = 19922484.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Bocciolini C, Dall'olio D, Cavazza S, Laudadio P: Schwannoma of cervical sympathetic chain: assessment and management. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):191-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannoma of cervical sympathetic chain: assessment and management.
  • Schwannoma arising from the cervical sympathetic chain is an uncommon benign nerve tumour.
  • This tumour most often presents as an asymptomatic solitary neck mass, with slow-growing and rare malignant degeneration.
  • The pathologic and radiological evaluations, treatment and postoperative complications of this neoplasm are discussed.
  • [MeSH-major] Ganglia, Sympathetic / pathology. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • [Cites] Am Surg. 2000 Jan;66(1):52-5 [10651348.001]
  • [Cites] Ann Otol Rhinol Laryngol. 2000 Jan;109(1):48-51 [10651412.001]
  • [Cites] Acta Otolaryngol. 2002 Jun;122(4):435-7 [12126003.001]
  • [Cites] Otolaryngol Head Neck Surg. 2002 Jul;127(1):127-8 [12161744.001]
  • [Cites] Otolaryngol Head Neck Surg. 1997 Dec;117(6):S206-10 [9419150.001]
  • [Cites] Radiology. 1984 Mar;150(3):729-35 [6695075.001]
  • [Cites] J Otolaryngol. 1992 Jun;21(3):186-8 [1404569.001]
  • [Cites] Laryngoscope. 1996 Dec;106(12 Pt 1):1548-52 [8948621.001]
  • [Cites] J Laryngol Otol. 1997 May;111(5):493-5 [9205620.001]
  • [Cites] Br J Ophthalmol. 2003 Mar;87(3):366-7 [12598461.001]
  • (PMID = 16450776.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 13
  • [Other-IDs] NLM/ PMC2639869
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44. Sheikh HY, Chakravarthy RP, Slevin NJ, Sykes AJ, Banerjee SS: Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. J Laryngol Otol; 2008 Jun;122(6):598-602
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  • [Title] Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties.
  • OBJECTIVES: To highlight the difficulty in making a correct diagnosis of benign schwannoma in the paranasal region, to raise awareness of this rare condition, and to suggest the most appropriate treatment.
  • Radiological appearances of local bone invasion and histological features of tumour unencapsulation and hypercellularity could give the mistaken impression of malignant disease and lead to unnecessary over-treatment.
  • [MeSH-major] Ethmoid Sinus / pathology. Neurilemmoma / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. England. Female. Humans. Male. Maxillary Sinus Neoplasms / pathology. Maxillary Sinus Neoplasms / radiography. Maxillary Sinus Neoplasms / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17705894.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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45. Agaram NP, Prakash S, Antonescu CR: Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. Am J Surg Pathol; 2005 Aug;29(8):1042-8
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  • [Title] Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety.
  • Plexiform schwannoma (PS) is one of the least common histologic variants of schwannoma.
  • However, the frequent cellular morphology associated with hyperchromatic nuclei, increased mitoses, and plexiform growth can suggest a malignant process, mainly a high-grade malignant peripheral nerve sheath tumor (MPNST).
  • Fifteen tumors were located in the deep somatic soft tissue (extremities, 8; retroperitoneum/pelvis, 3; trunk, 2; parotid, 1; vulva, 1) and 1 tumor was located in the thoracic esophagus.
  • The 8 superficial PSs showed increased cellularity and mild to moderate pleomorphism in 62% of cases but lacked tumor necrosis.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. S100 Proteins / analysis

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  • (PMID = 16006798.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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46. Trufant JW, Brenn T, Fletcher CD, Virata AR, Cook DL, Bosenberg MW: Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism. Am J Dermatopathol; 2009 Dec;31(8):808-13
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  • [Title] Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism.
  • Melanotic schwannoma is a rare markedly pigmented peripheral nerve sheath tumor comprising cells with prominent melanization and schwannian features.
  • We present the first 2 reported cases of melanotic schwannoma arising in patients with a history of nevus of Ota, a rare dermal melanosis believed to represent a failure of melanocyte migration to the epidermis during embryogenesis.
  • Case 1 involves a 40-year-old woman with a 1.8-cm, deeply pigmented, trigeminal nerve mass and pigmentation of the maxillary sinus mucosa and bone.
  • Microscopically, both masses consist of partially encapsulated epithelioid and spindle cells with abundant melanin pigment, arising in association with peripheral nerves.
  • Morphological, immunohistochemical, and ultrastructural features support a diagnosis of melanotic schwannoma.
  • Melanotic schwannoma is most often benign but has been associated with malignant behavior in some cases.
  • Distinguishing this nerve sheath tumor from malignant melanoma can be difficult but is of great clinical importance due to differences in prognosis and treatment.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Nevus of Ota / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Melanins. Middle Aged

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  • (PMID = 19786855.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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47. Waldron JS, Tihan T, Parsa AT: Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma. Neurosurgery; 2006 Oct;59(4):E939-40; discussion E940
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  • [Title] Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma.
  • OBJECTIVE: The authors present a report of a solitary fibrous tumor (SFT) arising from the intradural component of the VIth cranial nerve as it travels through the prepontine cistern.
  • In this study, the authors define a subpopulation of SFTs that seem to arise directly from nerve, rather than meninges, and clinically mimic the appearance of a schwannoma.
  • The patient was then taken to the operating room by a combined neurosurgical and ear, nose, and throat team, where the patient underwent a retrolabyrinthine/subtemporal craniotomy for tumor resection.
  • During resection of the prepontine component, the tumor was identified as originating from the left Cranial Nerve VI as it traversed through the prepontine cistern.
  • Resection of the tumor component involving the cavernous sinus and Meckel's cave was deferred for follow-up treatment with intensity-modulated radiation therapy.
  • This patient had an SFT masquerading as a VIth cranial nerve schwannoma.
  • Although the natural history of SFTs in the CNS is not completely understood, correct diagnosis is important, given the rate of recurrence found in the more common pleural-based SFT and examples of CNS SFTs with malignant features.
  • [MeSH-major] Abducens Nerve. Cranial Nerve Neoplasms / pathology. Fibroma / pathology. Neurilemmoma / pathology. Pons
  • [MeSH-minor] Adult. Cerebral Angiography. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Radiotherapy, Adjuvant

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  • (PMID = 17038929.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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48. Tagore KR, Krishna R, Charyulu PA, Latha PP: A rare case of cellular schwannoma in the pharynx. Indian J Pathol Microbiol; 2007 Oct;50(4):835-7
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  • [Title] A rare case of cellular schwannoma in the pharynx.
  • These tumors histologically mimic malignant peripheral nerve sheath tumors because of their growth pattern, high cellularity and mitotic activity, but they are relatively benign tumors with a tendency to recur but do not metastasize.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / pathology. Pharyngeal Neoplasms / diagnosis. Pharyngeal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neck / radiography. Tomography, X-Ray Computed

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  • (PMID = 18306575.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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49. López Alvarez F, Llorente Pendás JL, Coca Pelaz A, Fernández García MS, Cuello Bueno G, Suárez Nieto C: Malignant triton tumor of the infratemporal fossa. J Craniofac Surg; 2009 Jul;20(4):1282-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant triton tumor of the infratemporal fossa.
  • Malignant triton tumor is a very aggressive type of sarcoma that comprises rhabdomyoblasts and malignant Schwann cells.
  • It is a different entity from malignant schwannoma, characterized by their aggressiveness and poor prognosis.
  • However, the therapeutic plan should be individualized, taking into account the location and size of the primary tumor.
  • We report an unusual presentation of a malignant triton tumor located in the infratemporal fossa, describing its clinical and pathologic features, and we try to update the knowledge in the management of these tumors, including the use of molecular therapies.
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Diagnosis, Differential. Endoscopy. Fatal Outcome. Female. Humans. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19625850.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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50. Domanski HA, Akerman M, Engellau J, Gustafson P, Mertens F, Rydholm A: Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients. Diagn Cytopathol; 2006 Jun;34(6):403-12
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  • [Title] Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients.
  • There were 6 false-positive malignant diagnoses while 23 smears were considered insufficient and 7 inconclusive as to whether benign or malignant.
  • Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors.
  • [MeSH-major] Biopsy, Fine-Needle. Neurilemmoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. False Positive Reactions. Female. Humans. Male. Middle Aged. S100 Proteins / metabolism. Sarcoma / pathology. Sensitivity and Specificity

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  • (PMID = 16680779.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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51. Martin-Duverneuil N, Auriol M, Behin A, Bertrand JC, Chiras J: Facial malignant peripheral nerve sheath tumors. J Neuroradiol; 2006 Oct;33(4):237-49

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial malignant peripheral nerve sheath tumors.
  • BACKGROUND/PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms, only sporadically reported involving the maxillo-mandibular region (ten cases with CT or MR data).
  • Radiological features display a large spectrum of abnormalities from a well-delineated heterogeneous appearance simulating benign schwannoma to extensive erosive patterns.
  • Their development along the mandibular nerve, the absence of any target or central dot sign, their strong predominant peripheral enhancement must suggest the diagnosis of MPNSTs while irregular bone destruction or the detection of poorly defined margins with muscular infiltration are the most reliable criteria of malignancy.
  • [MeSH-major] Facial Neoplasms / pathology. Facial Neoplasms / radiography. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / radiography
  • [MeSH-minor] Adult. Female. Humans. Male

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  • (PMID = 17041528.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 46
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52. Fukushima S, Kageshita T, Wakasugi S, Matsushita S, Kaguchi A, Ishihara T, Ono T: Giant malignant peripheral nerve sheath tumor of the scalp. J Dermatol; 2006 Dec;33(12):865-8
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  • [Title] Giant malignant peripheral nerve sheath tumor of the scalp.
  • Herein, we describe a rare case of giant malignant peripheral nerve sheath tumor of the head in a 38-year-old Japanese man.
  • The tumor measured 210 mm at its largest diameter and was ulcerated, hemorrhagic, multilocular and non-mobile.
  • It should be noted that the patient stubbornly refused to see a doctor for a long time, resulting in the extreme growth of the tumor.
  • Dermatohistopathological findings of the biopsy indicated ancient schwannoma and total excision was therefore performed.
  • Post-mortem skin biopsy revealed features of malignant peripheral nerve sheath tumor.
  • We propose that the expressions of Ki67 and p16 should be checked for all lesions of peripheral nerve sheath tumor for distinguishing benign from malignant forms.
  • [MeSH-major] Neurilemmoma / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Fatal Outcome. Hemorrhage / pathology. Humans. Ki-67 Antigen / analysis. Male. Skin Ulcer / pathology

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  • (PMID = 17169091.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen
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53. Yang BB, Jiang H, Chang HY: Malignant triton tumour of the parapharyngeal space: a case arising from the cervical sympathetic nerve. J Laryngol Otol; 2008 May;122(5):531-4
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  • [Title] Malignant triton tumour of the parapharyngeal space: a case arising from the cervical sympathetic nerve.
  • BACKGROUND: Malignant triton tumour is a relatively rare, aggressive sarcoma comprising both malignant schwannoma cells and malignant rhabdomyoblasts.
  • Malignant triton tumour of the parapharyngeal space is exceptionally rare, with only one case being described in the literature.
  • Malignant triton tumour of the cervical sympathetic nerve has not previously been reported.
  • METHODS: We report a case involving the parapharyngeal space and arising from the cervical sympathetic nerve, and we review the management and outcome of the previous case reported in this rare location.
  • Owing to this specific localisation, adjuvant therapy in addition to complete resection may be important in the treatment of malignant triton tumour in this rare location.
  • [MeSH-major] Neurilemmoma / pathology. Pharyngeal Neoplasms / pathology. Sarcoma / pathology. Sympathetic Nervous System / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17498335.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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54. Kubo O, Chernov M, Izawa M, Hayashi M, Muragaki Y, Maruyama T, Hori T, Takakura K: Malignant progression of benign brain tumors after gamma knife radiosurgery: is it really caused by irradiation? Minim Invasive Neurosurg; 2005 Dec;48(6):334-9
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  • [Title] Malignant progression of benign brain tumors after gamma knife radiosurgery: is it really caused by irradiation?
  • Malignant transformation of benign neoplasm after radiosurgery is usually diagnosed based on the initial presence of benign tumor, its exposure to ionizing radiation, elapsed time from radiation exposure to malignant progression, and different histological characteristics or growth rate of the regrowing tumor comparing with those originally treated.
  • Three presented cases fulfilled these diagnostic criteria; however, it seems that progression of the tumors (schwannoma, meningioma, chordoma) resulted from the natural course of the disease, rather than represented side effects of gamma knife radiosurgery.
  • Evaluation of the proliferative potential of the benign neoplasm before radiosurgical treatment either directly, if tumor sampling is available, or indirectly, by calculation of the tumor growth rate and/or analysis of the data of the metabolic imaging (PET, MRS) is important for identification of "aggressive" subtypes, precise prediction of prognosis, and confirmation of the radiation-induced malignant transformation in cases of tumor regrowth.
  • [MeSH-major] Brain Neoplasms / surgery. Cell Transformation, Neoplastic / radiation effects. Chordoma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasms, Radiation-Induced / physiopathology. Neurilemmoma / surgery. Radiosurgery / adverse effects
  • [MeSH-minor] Adult. Brain Diseases / surgery. Cell Proliferation. Female. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 16432782.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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55. Mosunjac MB, Johnston EI, Mosunjac MI: Fine-needle aspiration cytologic diagnosis of metastatic melanotic schwannoma: familial case of a mother and daughter with Carney's complex and literature review. Diagn Cytopathol; 2007 Feb;35(2):130-4
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  • [Title] Fine-needle aspiration cytologic diagnosis of metastatic melanotic schwannoma: familial case of a mother and daughter with Carney's complex and literature review.
  • Carney's complex is an autosomal dominant, multisystem tumorous disorder that includes myxomas, spotty skin pigmentation, endocrine tumors, and peripheral nerve tumors.
  • Here, we describe the first known familial case of a mother and daughter, both presenting with malignant, already metastatic, pigmented schwannomas initially diagnosed as metastatic melanoma by CT guided fine-needle aspiration.
  • Patients with highly pigmented, extra-cutaneous lesions that are clinically and pathologically suspicious for metastatic malignant melanoma, without known primary tumor, should be evaluated for possible Carney's complex.
  • Additional screening of family members should be recommended to exclude the presence of potentially malignant neoplasms, such as psammomatous melanotic schwannomas.
  • [MeSH-major] Melanins / metabolism. Myxoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neurilemmoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Heart Neoplasms / genetics. Heart Neoplasms / pathology. Humans. Melanoma / diagnosis. Middle Aged. Nevus, Blue / diagnosis. Nevus, Blue / genetics. Nevus, Blue / pathology. Syndrome

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  • (PMID = 17230569.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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56. Li CS, Huang GS, Wu HD, Chen WT, Shih LS, Lii JM, Duh SJ, Chen RC, Tu HY, Chan WP: Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging. Clin Imaging; 2008 Mar-Apr;32(2):121-7
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  • [Title] Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging.
  • PURPOSE: The objective of this study was to differentiate the magnetic resonance (MR) imaging appearance of benign peripheral nerve sheath tumors (PNSTs) from that of malignant PNSTs.
  • MATERIALS AND METHODS: Twenty-six patients who underwent MR imaging and had a histologic diagnosis of benign (schwannoma, n=16; neurofibroma, n=1) or malignant (n=9) PNST were retrospectively reviewed.
  • =2.5 cm) was significantly smaller than that of the malignant tumors (8.2 cm, S.D.
  • Seventeen (65.4%) of the 26 tumors were spindle shaped or ovoid (12 benign and 5 malignant tumors).
  • Contiguity with specific nerves was identified in 15 (88.2%) of the 17 benign PNSTs but in none of the malignant tumors (P<.05).
  • Well-defined margins were noted in all 17 benign PNSTs but in only 3 (33.3%) of the 9 malignant tumors (P<.001).
  • Five (55.6%) of the 9 malignant PNSTs but none of the benign tumors showed signal intensity change in adjacent soft tissue (P<.05).
  • There was no significant difference in signal intensity between the benign and malignant tumors on T(1)-weighted, T(2)-weighted, and contrast-enhanced MR images.
  • The split fat and target signs were present more frequently in the benign PNSTs than in the malignant PNSTs (P<.05).
  • CONCLUSIONS: Benign and malignant PNSTs are often spindle shaped.
  • [MeSH-major] Magnetic Resonance Imaging. Peripheral Nervous System Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Gadolinium DTPA. Humans. Male. Middle Aged. Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / diagnosis. Neurofibroma / diagnosis

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  • (PMID = 18313576.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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57. Benz MR, Czernin J, Dry SM, Tap WD, Allen-Auerbach MS, Elashoff D, Phelps ME, Weber WA, Eilber FC: Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer; 2010 Jan 15;116(2):451-8
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  • [Title] Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign.
  • BACKGROUND: Correct pretreatment classification is critical for optimizing diagnosis and treatment of patients with peripheral nerve sheath tumors (PNSTs).
  • The aim of this study was to evaluate whether F18-fluorodeoxyglucose positron emission tomography (FDG PET) can differentiate malignant (MPNST) from benign PNSTs.
  • METHODS: Thirty-four adult patients presenting with PNST who underwent a presurgical FDG PET/computed tomography (CT) scan between February 2005 and November 2008 were included in the study.
  • Tumors were characterized histologically, by FDG maximum standardized uptake value (SUV(max) [g/mL]), and by CT size (tumor maximal diameter [cm]).
  • The accuracy of FDG PET for differentiating MPNSTs from benign PNSTs (neurofibroma and schwannoma) was evaluated by receiver operating characteristic (ROC) curve analysis.
  • SUV(max) was significantly higher in MPNST compared with benign PNST (12.0 +/- 7.1 vs 3.4 +/- 1.8; P < .001).
  • By ROC curve analysis, SUV(max) reliably differentiated between benign and malignant PNSTs (area under the ROC curve of 0.97).
  • Given the difficulties in clinically evaluating PNST and in distinguishing benign PNST from MPNST, FDG PET imaging should be used for diagnostic intervention planning and for optimizing treatment strategies.

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  • [ErratumIn] Cancer. 2010 Feb 1;116(3):775
  • (PMID = 19924789.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA086306; United States / NCI NIH HHS / CA / 5 P50 CA086306
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ NIHMS324300; NLM/ PMC3188986
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58. Fisher BJ, Dennis KE: Malignant epithelioid cranial nerve sheath tumor: case report of a radiation response. J Neurooncol; 2006 Jun;78(2):173-7
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  • [Title] Malignant epithelioid cranial nerve sheath tumor: case report of a radiation response.
  • Malignant epithelioid nerve sheath tumors (MESs) especially those involving intracranial cranial nerves are rare and thought to be radioresistant.
  • A 41-year-old man with progressive left facial weakness underwent an MRI that disclosed an enhancing lesion involving both V3 cranial nerve and the distal VIIth nerve.
  • Biopsy confirmed a malignant epithelioid schwannoma.
  • The tumor was resected but residual tumor was present at the cut end of the infraorbital nerve, within the oral cavity and at the brainstem.
  • Tumor was controlled for 38 months and then radiographic recurrence was resected from the infratemporal fossa outside the irradiated field.A new primary MES tumor developed at 69 months at the C1/C2 root levels at the lower edge of the previously irradiated field.
  • It was subtotally resected but by 77 months residual tumor had grown inferiorly down to C5 so this area was re-irradiated with a complicated 7-field approach to spare spinal cord.
  • Initially the tumor responded but ultimately progressed posteriorly where radiation dose was limited by spinal cord tolerance.
  • New involvement of the Xth cranial nerve was noted.
  • The long-term control of the original tumor despite positive margins argues for the use of radiotherapy in the treatment of these tumors.
  • [MeSH-major] Cranial Nerve Neoplasms / radiotherapy. Facial Nerve Diseases / radiotherapy. Nerve Sheath Neoplasms / radiotherapy. Neurilemmoma / radiotherapy. Trigeminal Nerve Diseases / radiotherapy
  • [MeSH-minor] Adult. Facial Nerve / pathology. Facial Nerve / surgery. Humans. Male. Radiotherapy Dosage. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / surgery

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  • (PMID = 16557352.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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59. Ziadi A, Saliba I: Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review. Auris Nasus Larynx; 2010 Oct;37(5):539-45
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  • [Title] Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review.
  • OBJECTIVES: The incidence of malignant peripheral nerve sheath tumor (MPNST) is approximately 0.001%.
  • (1) to review all cases of intracranial MPNST described in the literature, (2) to highlight the suspicion of intracranial MPNST, (3) to identify the gross pathology, the histopathology, the immunohistochemistry, (4) to discuss the differential diagnosis, the treatment, the recurrence rate, the follow-up, the incidence of metastasis and the prognosis.
  • We used the following Keywords: "malignant peripheral nerve sheath tumor", "cranial nerve", "neurosarcoma", "malignant schwannoma", "neurofibroma", "malignant neurofibroma" and "nerve tumor".
  • We considered cases where MPNST involved an intracranial cranial nerve.
  • RESULTS: We identified 32 cases of cranial MPNST including our case.
  • Most cases are developed sporadically (50%), 31% arise from a malignant transformation of schwannoma and 19% from a neurofibroma.
  • The cranial nerve VIII is the most involved (15/32), followed by the Vth (10/32) and the VIIth (5/32).
  • MPNST will strongly express protein S-100 and collagen IV-laminin.
  • 13 cases were treated with radiotherapy for tumor recurrence and metastasis.
  • CONCLUSION: MPNST of cranial nerves are very rare.
  • In neurofibroma, even though MPNST is mainly associated to type 1, we should keep in mind its association to NF2.
  • Inaccessibility of cranial MPNST may explain the subtotal resection and thus the poor prognosis.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Transformation, Neoplastic / pathology. Child. Child, Preschool. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / radiotherapy. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / radiotherapy. Neurofibroma / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / radiotherapy. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / radiotherapy. Neurofibromatosis 2 / surgery. Radiotherapy, Adjuvant. Spinal Neoplasms / mortality. Spinal Neoplasms / pathology. Spinal Neoplasms / secondary. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20399579.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
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60. Mineo JF, P-Ruchoux MM, Pasquier D, Rigolle H, Assaker R: [Primitive malignant melanoma arising in a spinal nerve root. A case report]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):133-7
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  • [Title] [Primitive malignant melanoma arising in a spinal nerve root. A case report].
  • We report the fourth case of primitive malignant melanoma arising in a spinal nerve root.
  • The T1-weighted MRI images showed a tumor hyperintensity, the T2-weighted images showed tumor isointensity and mild contrast enhancement.
  • Due to the scalloping of L3/L4 foramen with root enlargement and slow evolution (more than one year between the first symptom and surgery without clinical worsening), the initial preoperative diagnosis was L3 schwannoma.
  • The tumor was composed of irregular melanocytoid cells with high proliferation index (20%).
  • Immunohistochemistry showed melanin, HMB-45 and S100 positivity, but reticulin was negative (that eliminates malignant melanocytic schwannoma).
  • So, the final diagnosis was intradural primitive malignant melanoma.
  • Radiotherapy was performed on the site of the tumor.
  • The most common tumor with root enlargement and bony scalloping is the benign schwannoma.
  • Despite the above described radiological features, MRI characteristics (hyperintensity when images are T1-weighted) suggest a melanocytic tumor, a tumor with a high adipose component or an intratumoral bleeding.
  • Specific MRI sequences can eliminate adipose tissue tumor, but diagnosis between melanin and methemoglobin is still difficult.
  • According to the index of proliferation, a primitive central melanocytic lesion can be a meningeal melanocytoma (considered as benign) or a primitive malignant melanoma.
  • These tumors show identical protein expressions in immunohistochemistry, and their prognosis is very variable (some long-term remissions are reported for malignant melanomas and fast disseminations are described for meningeal melanocytomas treated by sub-total surgery).
  • The L3/L4 foramen scalloping is unusual for a malignant lesion with theoretic high-speed development.
  • The histological features of malignant lesion with benign clinical features lead to interrogation upon the actual pathologic classification.
  • [MeSH-major] Melanoma / pathology. Spinal Neoplasms / pathology. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adult. Antigens, Neoplasm. Cell Proliferation. Fatal Outcome. Female. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Melanins / metabolism. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. Neurologic Examination. S100 Proteins / metabolism

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  • (PMID = 16840974.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanins; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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61. Scheithauer BW, Erdogan S, Rodriguez FJ, Burger PC, Woodruff JM, Kros JM, Gokden M, Spinner RJ: Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: a clinicopathologic study of 17 cases. Am J Surg Pathol; 2009 Mar;33(3):325-38
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  • [Title] Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: a clinicopathologic study of 17 cases.
  • Malignant peripheral nerve sheath tumors (MPNSTs) arising from cranial nerves or their branches are very uncommon.
  • In addition, 1 tumor involved the optic chiasm (n=1).
  • Only 1 tumor arose in brain parenchyma of (frontal lobe).
  • One patient with a vestibular tumor and presumed NF2 had previously undergone resection of a contralateral vestibular cellular schwannoma.
  • One posterior fossa tumor was a malignant melanotic schwannoma.
  • Four patients had postirradiation malignant peripheral nerve sheath tumors, 2 having been treated for optic chiasm glioma, both being NF1 affected.
  • Identifiable precursor lesions included schwannoma (n=4), plexiform neurofibroma (n=2), and solitary intraneural neurofibroma (n=2).
  • Malignant cranial nerve sheath tumors are rare and are associated with the same poor prognosis as those of spinal nerves at other sites.
  • [MeSH-major] Brain Neoplasms / pathology. Cranial Nerve Neoplasms / pathology. Nerve Sheath Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 19065105.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Nabeshima K, Iwasaki H, Nishio J, Koga K, Shishime M, Kikuchi M: Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential. Anticancer Res; 2006 Mar-Apr;26(2B):1359-67
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  • [Title] Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential.
  • However, their roles in peripheral nerve sheath tumors (PNSTs) have rarely been investigated.
  • MATERIALS AND METHODS: In this study, the immunohistochemical expression of 6 MMPs, their 3 inhibitors and emmprin, an MMP inducer, was examined in 14 schwannomas, 14 neurofibromas and 12 malignant peripheral nerve sheath tumors (MPNSTs) in relation to malignant potentials.
  • Moreover, the expression patterns of MMP-1 and gelatinase B (MMP-9) could divide PNSTs into two groups: schwannoma versus neurofibroma/MPNST.
  • CONCLUSION: These results suggest that emmprin and MT1-MMP may be malignant potential-related proteins in PNSTs, and that MMP-1 and 9 may help differentiation between schwannoma and neurofibroma, especially in their plexiform types.
  • [MeSH-major] Antigens, CD147 / biosynthesis. Matrix Metalloproteinases / biosynthesis. Nerve Sheath Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Immunohistochemistry. Isoenzymes / biosynthesis. Male. Matrix Metalloproteinases, Membrane-Associated. Middle Aged. Neurilemmoma / enzymology. Neurilemmoma / metabolism. Neurilemmoma / pathology. Neurofibroma / enzymology. Neurofibroma / metabolism. Neurofibroma / pathology

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  • (PMID = 16619545.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / BSG protein, human; 0 / Isoenzymes; 136894-56-9 / Antigens, CD147; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases, Membrane-Associated
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63. Ayabe T, Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Ninomiya H, Ogata K, Onitsuka T: [Clinical assessment of the thoracic surgical diseases associated with von Recklinghausen's disease]. Kyobu Geka; 2005 Mar;58(3):219-25
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  • The mediastinal tumors were neurofibroma (n = 3), malignant schawannoma (n = 1), ganglioneurinoma (n = 2), and pericardial cyst (n = 1).
  • Malignant neoplasms were recognized in 2 cases (25%).
  • The postoperative survival was 10 months for malignant schwannoma, and 8 months for esophageal cancer, and the others were alive.
  • For 1 case of neurofibromas, there was observed to be the reoperated one after the postoperative recurrence. von Recklinghausen's disease are apt to be complicated with thoracic surgical neoplasms, it should be required a careful and systemic exploration especially for malignant neoplasms.
  • [MeSH-minor] Adolescent. Adult. Aged. Esophageal Neoplasms / surgery. Female. Humans. Male. Mediastinal Neoplasms / surgery. Middle Aged. Retrospective Studies

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  • (PMID = 15776741.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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64. White JB, Scheithauer BW, Amrami KK, Babovic-Vuksanovic D, Spinner RJ: Contiguous conventional and plexiform schwannomas. Report of two cases. J Neurosurg; 2006 Feb;104(2):319-24
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  • The authors present clinical, imaging, and histological features of two adult patients found to harbor a conventional schwannoma contiguous with a deep plexiform schwannoma.
  • The proximal forearm lesions consisted of a conventional schwannoma and an underlying plexiform component.
  • The authors believe that a more careful examination of patients with NF2 may show that these people have a higher incidence of plexiform schwannoma than previously thought.
  • Pathological confirmation is crucial in distinguishing plexiform schwannomas from plexiform neurofibromas, because the latter are directly associated with NF1 and have a significant tendency to undergo malignant transformation.
  • To the best of the authors' knowledge, this is the first report of a conventional schwannoma contiguous with a deep plexiform schwannoma.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neurilemmoma / pathology. Neurofibroma, Plexiform / pathology. Neurofibromatosis 2 / complications
  • [MeSH-minor] Adult. Arm / innervation. Arm / pathology. Cell Transformation, Neoplastic. Functional Laterality. Humans. Male

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  • (PMID = 16509508.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Ghosh A, Talwar OP, Pradhan SV: Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience. Kathmandu Univ Med J (KUMJ); 2010 Jan-Mar;8(29):97-101
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  • [Title] Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience.
  • BACKGROUND: There are four major lesions which may arise in the peripheral nerve, namely neuroma, schwannoma, neurofibroma and malignant peripheral nerve sheath tumor.
  • OBJECTIVE: In the present study we look into the spectrum of peripheral neural tumors including their age distribution site distribution and histopathology.
  • All histopathologically diagnosed cases of primary lesions of peripheral nerve during the period Jan 2000 to Nov 2009 were reviewed and the data were analysed.
  • RESULT: A total of 114 cases of peripheral neural lesions were reported in the same period.
  • Total number of nonmalignant cases was 106 (93%) while malignant cases were 8 (7%).
  • Among the nonmalignant cases neurofibroma was the commonest (51 cases, 45% of all) closely followed by schwannoma (39 cases, 34% of all).
  • Among the schwannoma cases 4 were diagnosed as ancient schwannoma with presence of bizarre cells with hyperchromatic nuclei.
  • The commonest site involved for both schwannoma and neurofibroma was scalp-face-neck followed by back.
  • The age range for schwannoma was 16 to 75 years whereas the same for the neurofibroma cases was 2 to 82 years.
  • MPNST cases were seen in the age range of 40 to 72 with 3 cases in upper extremity, 3 in lower extremity and 1 each in lip and cheek.
  • CONCLUSION: The majority of the tumor are benign and the commonest benign tumor was neurofibroma of sporadic type, closely followed by schwannoma.
  • [MeSH-major] Nerve Sheath Neoplasms / epidemiology. Neurilemmoma / epidemiology. Neurofibroma / epidemiology. Neuroma / epidemiology. Peripheral Nervous System Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 21209517.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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66. Zhang QH, Liu HS, Kong F: [Endoscopic endonasal surgery for tumors of petroclival region and infratemporal fossa]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Jul;40(7):488-92
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  • However, most of endoscopic surgery limited to the repair of cerebrospinal rhinorrhea, decompression of traumatic optic nerve, hypophysectomy, etc.
  • There were 5 chordoma, 1 esthesioneuroblastoma, 1 chondrosarcoma, 1 lymphoma, 1 craniopharyngioma, 1 hemangioblastoma, 4 meningioma, 1 schwannoma, and 2 metastatic carcinoma.
  • RESULTS: Total tumor removal was obtained in 15 cases, subtotal removal in 2 case.
  • All of 5 cases with malignant tumors followed up for longer than 2 years were no recurrence and death.
  • Using neuronavigation system, it is helpful to determining anatomical landmark and removing the tumor completely and securely.
  • [MeSH-minor] Adult. Aged. Chordoma / surgery. Female. Humans. Male. Meningioma / surgery. Middle Aged. Nose / surgery

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  • (PMID = 16200953.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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67. Katabathina VS, Vikram R, Nagar AM, Tamboli P, Menias CO, Prasad SR: Mesenchymal neoplasms of the kidney in adults: imaging spectrum with radiologic-pathologic correlation. Radiographics; 2010 Oct;30(6):1525-40
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  • Benign mesenchymal renal tumors include angiomyolipoma, leiomyoma, hemangioma, lymphangioma, juxtaglomerular cell tumor, renomedullary interstitial cell tumor (medullary fibroma), lipoma, solitary fibrous tumor, and schwannoma.
  • Malignant renal tumors of mesenchymal origin include leiomyosarcoma, rhabdomyosarcoma, angiosarcoma, osteosarcoma, synovial sarcoma, fibrosarcoma, malignant fibrous histiocytoma, and solitary fibrous tumor.
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans

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  • [Copyright] © RSNA, 2010.
  • (PMID = 21071373.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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68. Ducic Y, Oxford L, Pontius AT: Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg; 2006 Mar;134(3):466-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Eight patients with various neoplasms of the superomedial PPS were retrospectively reviewed for type of neoplasm, size, success with the transoral approach, need for conversion to another approach, length of hospitalization, and complications.
  • The most common pathology encountered was that of schwannoma.
  • Mean tumor size was 3.3 cm (range, 1.5 to 7 cm).
  • This approach alone may not provide adequate access for resection of malignant lesions especially those with extension intracranially or to more inferior or laterally placed lesions of the parapharyngeal space.
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carotid Artery, Internal / pathology. Child. Female. Follow-Up Studies. Humans. Intraoperative Care. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications. Retrospective Studies. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 16500446.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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69. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • No example of melanotic schwannoma was recorded.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Yang CY, Chou CW, Lin MB, Li CF: Schwannomas of the left adrenal gland and posterior mediastinum. J Chin Med Assoc; 2009 Feb;72(2):83-7
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  • Schwannoma is a rare tumor of neural crest cell origin.
  • Pathologic studies showed a picture of benign schwannoma.
  • In conclusion, preoperative differentiation of benign schwannoma from malignant peripheral nerve sheath tumor or other tumors is important for good prognosis.
  • Total excision of benign schwannoma is associated with favourable outcome in patients.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Mediastinal Neoplasms / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 19251536.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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71. Cheng B, Zhong L, Ding F, Xie HP, Wang Y, Yang YZ, Liu M, Wan J: [A comparative study of the diagnostic value of endoscopic ultrasonography with pathological features of upper gastrointestinal mesenchymal tumors]. Zhonghua Nei Ke Za Zhi; 2009 Sep;48(9):724-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: In the 72 cases of upper digestive tract GIMTs, 37 cases were diagnosed as stromal tumor with pathological and immunohistochemical methods (51.4%); 21 of them were malignant, accounting for 56.7% of the stromal tumors.
  • Thirty-four cases were diagnosed as leiomyoma (47.2%) and 1 case as schwannoma (1.4%).
  • EUS showed that 38 cases were originated from the muscularis mucosae layer; 33 of them were leiomyoma and 5 stromal tumor.
  • Thirty-two cases were gastric GIMTs, EUS showed that 2 cases originating from the muscularis mucosae layer were gastric stromal tumor.
  • Of the 30 cases originating from the muscularis propria layer, 28 cases were stromal tumor, 1 case was leiomyoma and 1 case was schwannoma.
  • The sensitivity and the specificity of EUS in distinguishing benign and malignant stromal tumors according to sonographic characteristics were 81.0% and 93.8% respectively.
  • CONCLUSION: Stromal tumor is more common in stomach mesenchymal neoplasms and is more often originated from the muscularis propria layer in EUS; leiomyoma is more common in esophagus and is more often originated from the muscularis mucosae layer.
  • The diagnostic sensitivity and specificity of EUS are high in distinguishing benign and malignant character of upper digestive tract GIMTs.
  • [MeSH-minor] Adolescent. Adult. Aged. Endosonography. Female. Humans. Male. Middle Aged. Sensitivity and Specificity. Young Adult

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  • (PMID = 20079206.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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72. Uranues S, Grossman D, Ludwig L, Bergamaschi R: Laparoscopic partial splenectomy. Surg Endosc; 2007 Jan;21(1):57-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Data on consecutive patients presenting with localized benign or malignant disease of the spleen were included in a prospective database.
  • The indications included splenomegaly of unknown origin, splenic cysts, benign tumors (hamartoma), and metastasis from ovarian carcinoma and schwannoma.
  • CONCLUSION: Laparoscopic partial splenectomy is safe for patients with localized benign or malignant disease of the spleen.
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma / secondary. Carcinoma / surgery. Cysts / surgery. Databases, Factual. Female. Hamartoma / surgery. Humans. Length of Stay. Male. Middle Aged. Neurilemmoma / secondary. Neurilemmoma / surgery. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Pleural Effusion / etiology. Splenic Neoplasms / surgery. Splenomegaly / surgery. Time Factors

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  • (PMID = 17031738.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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73. Bisogno G, Ferrari A, Bergeron C, Scagnellato A, Prete A, Alaggio R, Casanova M, D'Angelo P, Di Cataldo A, Carli M: The IVADo regimen--a pilot study with ifosfamide, vincristine, actinomycin D, and doxorubicin in children with metastatic soft tissue sarcoma: a pilot study of behalf of the European pediatric Soft tissue sarcoma Study Group. Cancer; 2005 Apr 15;103(8):1719-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The IVADo regimen--a pilot study with ifosfamide, vincristine, actinomycin D, and doxorubicin in children with metastatic soft tissue sarcoma: a pilot study of behalf of the European pediatric Soft tissue sarcoma Study Group.
  • BACKGROUND: The role of doxorubicin (Doxo) as part of multidrug regimens used to treat children with soft tissue sarcoma (STS) is controversial.
  • METHODS: Between July 2002 and February 2004, 29 evaluable patients were enrolled in this study; 19 patients had rhabdomyosarcoma, 5 patients had peripheral neuroectodermal tumor, and 5 patients had other types of STS.
  • Three courses of IVADo were to be administered in the initial part of treatment and analyzed for toxicity and tumor response.
  • Nonhematologic toxicity included Grade 3-4 mucositis (6.5% of cycles), constipation (9.7%), and peripheral neuropathy (6.5%).
  • All but 1 patient with a malignant schwannoma showed some degree of tumor volume reduction; however, considering only complete and partial remissions, the response rate was 76% (+/- 7.9%).
  • This combination will be investigated in high-risk patients with rhabdomyosarcoma in a randomized trial launched by the European pediatric Soft tissue sarcoma Study Group.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Sarcoma / drug therapy. Sarcoma / secondary
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Dactinomycin / administration & dosage. Disease-Free Survival. Doxorubicin / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Infant. Male. Pilot Projects. Risk Factors. Vincristine / administration & dosage

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 15754335.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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74. Ishimaru A, Hasegawa J, Shinbo K, Arahara T, Kinoshita Y, Shimoyama E, Korehisa M, Oonuki M, Miyazawa T, Itabashi M: [A case of retroperitoneal tumor successfully resected thanks to effective chemotherapy]. Gan To Kagaku Ryoho; 2009 Jun;36(6):1007-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of retroperitoneal tumor successfully resected thanks to effective chemotherapy].
  • First, pathological diagnosis of sarcoma was made by fine needle aspiration, then secondary pathological diagnosis of suspected malignant schwannoma was made by a partial resection.
  • The preoperative diagnosis was difficult in this case, and the tumor had grown too large after partial resection to surgically resect.
  • The effective chemotherapy reduced this tumor enough to allow successful resection.
  • [MeSH-minor] Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / pathology. Carcinoma, Embryonal / surgery. Humans. Male. Young Adult

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  • (PMID = 19542726.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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75. Takahama A Jr, León JE, de Almeida OP, Kowalski LP: Nonlymphoid mesenchymal tumors of the parotid gland. Oral Oncol; 2008 Oct;44(10):970-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 15 out of 19 were benign tumors, including 5 lymphangiomas, 5 neurofibromas, and one case each of schwannoma, lipoma, solitary fibrous tumor, meningioma and giant cell tumor.
  • Four malignant tumors were classified as rhabdomyosarcoma, fibrosarcoma, Langerhans cell histiocytosis and endodermal sinus tumor.
  • From the malignant cases, only the patient with fibrosarcoma died due the tumor, the other three are alive with no signs of recurrence.
  • In our series of 600 cases of parotid gland tumors, nonlymphoid mesenchymal tumors corresponded to 3.16% (19 cases; 15 benign and 4 malignant).
  • [MeSH-minor] Adolescent. Adult. Aged. Brazil. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Female. Fibrosarcoma / pathology. Histiocytosis, Langerhans-Cell / pathology. Humans. Infant. Male. Middle Aged. Neurofibroma / pathology. Rhabdomyosarcoma / pathology. Young Adult

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  • (PMID = 18282791.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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76. Aron M, Kapila K, Verma K: Neural tumours of the neck presenting as thyroid nodules: a report of three cases. Cytopathology; 2005 Aug;16(4):206-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report two cases of schwannoma and one case of a malignant peripheral nerve sheath tumour (MPNST) of the neck, which presented as thyroid nodules and evaluate the role of cytology in identifying these tumours.
  • RESULTS: Both the cases of schwannoma were correctly identified on cytology while the case of MPNST could only be typed as a spindle cell tumour.
  • CONCLUSIONS: Schwannomas of the neck are easily identifiable on cytology compared with MPNST.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / diagnosis. Thyroid Gland / pathology
  • [MeSH-minor] Adult. Cytodiagnosis. Diagnosis, Differential. Female. Goiter, Nodular / diagnosis. Humans. Male

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  • (PMID = 16048507.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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77. Wasa J, Nishida Y, Suzuki Y, Tsukushi S, Shido Y, Hosono K, Shimoyama Y, Nakamura S, Ishiguro N: Differential expression of angiogenic factors in peripheral nerve sheath tumors. Clin Exp Metastasis; 2008;25(7):819-25

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of angiogenic factors in peripheral nerve sheath tumors.
  • It is difficult to differentiate some malignant peripheral nerve sheath tumors (MPNST) from benign peripheral nerve sheath tumors (BPNST) histologically, and to predict the clinical outcome of patients with MPNST.
  • In this study, the expression of VEGF and MVD were evaluated immunohistochemically in 22 cases of MPNST, 14 of neurofibroma and 19 of schwannoma and correlation of the staining grade of VEGF or MVD and the various clinical factors were analyzed, and statistically evaluated.
  • Statistically higher positive staining for VEGF was observed in MPNST compared to neurofibroma (P=0.004) and schwannoma (P<0.001).
  • Even low grade MPNST showed higher VEGF positive staining than neurofibroma.
  • Moreover, high VEGF expression statistically correlated with the poor prognosis of the patients with MPNST (P=0.015).
  • Although MVD in MPNST was significantly higher than that in neurofibroma (P=0.038) and schwannoma (P<0.001), MVD could not predict the prognosis of the patients with MPNST.
  • Although VEGF mRNA expression tended to be higher in MPNST compared to neurofibroma, the difference was not significant.
  • Levels of VEGF protein expression serve as a novel diagnostic and prognostic tools for peripheral nerve sheath tumors.
  • [MeSH-major] Nerve Sheath Neoplasms / chemistry. Vascular Endothelial Growth Factor A / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neurilemmoma / blood supply. Neurilemmoma / chemistry. Neurofibroma / blood supply. Neurofibroma / chemistry. RNA, Messenger / analysis

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  • (PMID = 18679811.001).
  • [ISSN] 0262-0898
  • [Journal-full-title] Clinical & experimental metastasis
  • [ISO-abbreviation] Clin. Exp. Metastasis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A
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78. Koutsimpelas D, Stripf T, Heinrich UR, Mann WJ, Brieger J: Expression of vascular endothelial growth factor and basic fibroblast growth factor in sporadic vestibular schwannomas correlates to growth characteristics. Otol Neurotol; 2007 Dec;28(8):1094-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Vestibular schwannoma is a benign, slow-growing neoplasm that accounts for 6% of all intracranial tumors.
  • Because several angiogenic and cytotrophic factors have been described to be involved in the growth of malignant tumors, we initiated this study to examine 2 major representatives of such growth factors in VS and their possible correlation to the growth characteristics of sporadic VSs.
  • The mRNA expression and the protein expression of both growth factors correlated positive to tumor volume, to tumor growth index, and to MVD.
  • CONCLUSION: The bFGF and VEGF mRNA expression and the bFGF and VEGF protein expression in sporadic VS correlates to the tumour volume, to the tumor growth index, and to the MVD.
  • [MeSH-minor] Adult. Aged. Antigens, CD31 / biosynthesis. Antigens, CD31 / genetics. Capillaries / pathology. Disease Progression. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neovascularization, Pathologic / genetics. Neovascularization, Pathologic / pathology. RNA, Messenger / analysis. RNA, Messenger / biosynthesis. Regional Blood Flow / physiology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17721409.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
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79. Erzen D, Sencar M, Novak J: Retroperitoneal sarcoma: 25 years of experience with aggressive surgical treatment at the Institute of Oncology, Ljubljana. J Surg Oncol; 2005 Jul 1;91(1):1-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal sarcoma: 25 years of experience with aggressive surgical treatment at the Institute of Oncology, Ljubljana.
  • BACKGROUND AND OBJECTIVES: Retroperitoneal sarcomas are rare malignant tumors with an aggressive course of disease and high local recurrence rate.
  • Out of the rest 139 patients, 102 patients had localized retroperitoneal sarcoma, and 37 patients had retroperitoneal sarcoma with distant metastases Leiomyosarcoma was the most common type of histology, followed by liposarcoma and schwannoma.
  • Their referral status was as follow: 56 had primary sarcoma, 20 residual sarcoma after operation elsewhere and 26 already recurrent sarcoma.
  • We removed surgically primary tumor, recurrent sarcoma and metastases, whenever possible.
  • RESULTS: Complete resection was done in 97 of 102 patients with localized sarcoma (resectability rate 95%); in 55 patients, R0 resection was made, in 42 patients, R1 resection, in 3 patients, debulking procedure, and in 2 patients biopsy alone.
  • In 118, patients at least one organ was resected completely or partially en bloc with tumor.
  • The 5-, 10-, and 15-year survivals of patients with localized sarcoma were 52%, 36%, and 22%, respectively.
  • High tumor grade was associated with poor survival.
  • The 5-year local recurrence rate of patients with primary sarcoma and of those with locally recurrent sarcoma was 37% and 71%, respectively (P = 0.04).
  • Until there are no other treatment modalities, aggressive surgery for recurrent sarcoma is recommended.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Retroperitoneal Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Slovenia / epidemiology. Survival Rate

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  • (PMID = 15999353.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Jung YH, Hah JH, Sung MW, Kim KH: Parotidotomy approach for a midcheek mass: a new surgical strategy. Laryngoscope; 2010 Mar;120(3):495-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The standard superficial parotidectomy approach was modified to dissect facial nerve branches selectively to obtain a symmetric facial contour.
  • The parotid gland was fully bisected along the course of the zygomatic and buccal branches of the facial nerve to provide access to the midcheek mass.
  • The parotidotomy approach was accomplished in two cases with a malignant tumor (one acinic cell carcinoma, one low-grade mucoepidermoid carcinoma), four with a benign tumor (two pleomorphic adenoma, one basal cell adenoma, one facial nerve schwannoma), and in one case with a chronic inflammatory lesion (chronic sialadenitis).
  • In no case was facial nerve paralysis or Frey's syndrome noticed after this approach.
  • For the two malignant tumors, there was no evidence of recurrence or metastasis at 2-year and 2.5-year follow-ups.
  • [MeSH-minor] Adolescent. Adult. Aged. Esthetics. Facial Nerve / surgery. Female. Humans. Male. Middle Aged. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20058313.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Morris BS, Nagar AM, Morani AC, Chaudhary RK, Garg PA, Chudgar PD, Raut AA: Blood-fluid levels in the brain. Br J Radiol; 2007 Jun;80(954):488-98
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  • The group of four primary intracranial neoplasms lists an oligodendroglioma, a recurrent tumour in a case of Von Hippel-Lindau syndrome, a Grade 3 astrocytoma and an acoustic schwannoma.
  • Four cases of metastatic deposits to the brain were each secondary to primary malignant neoplasms of the breast, liver, ovary and lung.
  • [MeSH-minor] Adolescent. Adult. Aged. Blood. Blood-Brain Barrier. Body Fluids. Brain / pathology. Brain / physiopathology. Brain / radiography. Brain Neoplasms / pathology. Brain Neoplasms / physiopathology. Brain Neoplasms / radiography. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Tomography, X-Ray Computed / methods

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  • (PMID = 17684079.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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82. Ohwada S, Hamada K, Kawate S, Sunose Y, Tomizawa N, Yamada T, Okabe T, Ogawa T, Sato Y: Left renal vein graft for vascular reconstruction in abdominal malignancy. World J Surg; 2007 Jun;31(6):1215-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A total of 113 patients underwent vascular resection including the PV (42 patients), IVC (68 patients), and HV (3 patients) for hepatobiliary-pancreatic or abdominal tumor resection.
  • The IVC was partially resected in 1 patient with advanced colon cancer and 1 with malignant schwannoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / mortality. Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / pathology. Bile Ducts, Intrahepatic / surgery. Carcinoma, Hepatocellular / mortality. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Carcinoma, Renal Cell / mortality. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Cholangiocarcinoma / surgery. Female. Follow-Up Studies. Hepatectomy. Hospital Mortality. Humans. Kidney Neoplasms / mortality. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Liver Neoplasms / mortality. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Male. Microsurgery. Middle Aged. Neoplasm Invasiveness. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / mortality. Tomography, X-Ray Computed. Vascular Patency / physiology

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  • (PMID = 17453283.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Ferraresi V, Ciccarese M, Cercato MC, Nuzzo C, Zeuli M, Di Filippo F, Giannarelli D, Cognetti F: Gemcitabine at fixed dose-rate in patients with advanced soft-tissue sarcomas: a mono-institutional phase II study. Cancer Chemother Pharmacol; 2008 Dec;63(1):149-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Fourteen patients with advanced locally unresectable and/or metastatic, pretreated STSs (seven leiomyosarcoma, three malignant schwannoma, one synovialsarcoma, one malignant fibrous histiocytoma, one endometrial stromal cell sarcoma, one undifferentiated) were treated with gemcitabine 10 mg/m(2)/min/week over 100 min given for 3 weeks out of 4.
  • Three patients (two leiomyosarcoma and one schwannoma) (21%) obtained a stabilization of disease.
  • Nevertheless, an interesting tumor growth control rate was observed in specific histological variants (i.e., leiomyosarcoma), thus confirming data from recent controlled clinical trials.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Disease Progression. Dose-Response Relationship, Drug. Female. Gastrointestinal Diseases / chemically induced. Hematologic Diseases / chemically induced. Humans. Male. Middle Aged

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  • (PMID = 18351342.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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84. Suwonpanich P, Laothamatas J: Magnetic resonance venography in intracranial veno-occlusive disease. J Med Assoc Thai; 2007 May;90(5):913-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Contributing factors in patients diagnosed to have intracranial veno-occlusive disease in the present series were birth control pill in take, tumor (meningioma, and malignant schwannoma of the scalp), blood dyscrasia, AVM, hypotension, and abscess.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Phlebography. Retrospective Studies

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  • (PMID = 17596045.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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85. Misra MC, Bhattacharjee HK, Hemal AK, Bansal VK: Laparoscopic management of rare retroperitoneal tumors. Surg Laparosc Endosc Percutan Tech; 2010 Jun;20(3):e117-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Due to their close proximity to major vessels, large size, variable location, and unknown malignant status, retroperitoneal tumors are frequently managed by open surgical exploration.
  • The histology reported retroperitoneal ganglioneuroma, retroperitoneal schwannoma, and retroperitoneal paraganglioma.
  • There has been no tumor recurrence at a mean follow-up of 39 months.
  • [MeSH-major] Ganglioneuroma / surgery. Laparoscopy. Neurilemmoma / surgery. Paraganglioma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged

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  • (PMID = 20551790.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Hirasawa S, Tsushima Y, Takei H, Hirasawa H, Taketomi-Takahashi A, Takano A, Oriuchi N, Endo K: Inverse correlation between tumor perfusion and glucose uptake in human head and neck tumors. Acad Radiol; 2007 Mar;14(3):312-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inverse correlation between tumor perfusion and glucose uptake in human head and neck tumors.
  • RATIONALE AND OBJECTIVES: We sought to determine the relationship between tumor blood flow and glucose uptake in head and neck tumors using perfusion computed tomography (PCT) and fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET).
  • Sixteen patients (mean age, 67 years; age range, 36-89 years) who had known or suspected head and neck tumors (15 malignant tumors and one schwannoma) underwent PCT and FDG PET examinations.
  • Tumor area was measured on conventional CT images.
  • A significant negative correlation between arterial perfusion and FDG SUV was found for malignant tumors (r = -0.538, P = .04, n = 15).
  • CONCLUSION: There was an inverse relationship between arterial perfusion and glucose uptake of head and neck malignant tumors, suggesting that the malignant tumors may depend on anaerobic glycolysis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Radiopharmaceuticals

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  • (PMID = 17307664.001).
  • [ISSN] 1076-6332
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; IY9XDZ35W2 / Glucose
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87. Saraswathy A, Jayasree RS, Baiju KV, Gupta AK, Pillai VP: Optimum wavelength for the differentiation of brain tumor tissue using autofluorescence spectroscopy. Photomed Laser Surg; 2009 Jun;27(3):425-33
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  • [Title] Optimum wavelength for the differentiation of brain tumor tissue using autofluorescence spectroscopy.
  • OBJECTIVE: The role of autofluorescence spectroscopy in the detection and staging of benign and malignant brain tumors is being investigated in this study, with an additional aim of determining an optimum excitation wavelength for the spectroscopic identification of brain tumors.
  • MATERIALS AND METHODS: The present study involves in-vitro autofluorescence monitoring of different human brain tumor samples to assess their spectroscopic properties.
  • The autofluorescence measurement at four different excitation wavelengths 320, 370, 410, and 470 nm, were carried out for five different brain tumor types: glioma, astrocytoma, meningioma, pituitary adenoma, and schwannoma.
  • RESULTS: The fluorescence spectra of tumor tissues showed significant differences, both in intensity and in spectral profile, from those of adjacent normal brain tissues at all four excitation wavelengths.
  • Of the four excitation wavelengths being considered, 470 nm appeared to be the optimal wavelength for detecting tissue fluorescence of brain tumor tissues.
  • CONCLUSIONS: In conclusion, the spectroscopic luminescence measurements carried out in this study revealed significant differences between tumor tissue and adjacent normal tissue of human brains for all the tumor types tested, except for pituitary adenoma.
  • From the results of this study we conclude that excitation wavelengths ranging from 410-470 nm are most suitable for the detection of brain tumor tissue.
  • [MeSH-minor] Adolescent. Adult. Aged. Algorithms. Astrocytoma / pathology. Child. Child, Preschool. Discriminant Analysis. Female. Glioma / pathology. Humans. Male. Meningioma / pathology. Middle Aged. Neoplasm Staging. Neurilemmoma / pathology. Pituitary Neoplasms / pathology. Principal Component Analysis

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  • (PMID = 19025404.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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88. Wang W, Montgomery E, Epstein JI: Benign nerve sheath tumors on urinary bladder biopsy. Am J Surg Pathol; 2008 Jun;32(6):907-12
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  • [Title] Benign nerve sheath tumors on urinary bladder biopsy.
  • Benign nerve sheath tumors (schwannoma and neurofibroma) involving the urinary bladders are rare with only case reports and limited series.
  • Both cases with schwannoma had only bladder involvement.
  • Neither recurrence nor malignant transformation was demonstrated on follow-up.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurilemmoma / pathology. Neurofibroma / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Child. Child, Preschool. Female. Humans. Male. Middle Aged

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  • (PMID = 18425043.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Kang GC, Soo KC, Lim DT: Extracranial non-vestibular head and neck schwannomas: a ten-year experience. Ann Acad Med Singapore; 2007 Apr;36(4):233-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: We present a series of head and neck extracranial non-vestibular schwannomas treated during a ten-year period, assessing epidemiology, presenting signs and symptoms, location, nerve of origin, diagnostic modalities, treatment and clinical outcome.
  • Treatment for all but 2 cases was complete excision with nerve preservation.
  • Two cases of facial schwannoma required sacrifice of the affected nerve portion with nerve reconstruction.
  • All facial schwannoma patients suffered postoperative facial palsy with only partial resolution (mean final House-Brackman grade, 3.25/6).
  • Among non-facial schwannoma patients, postoperative neural deficit occurred in 12 with partial to complete resolution in 7.
  • No schwannoma was malignant and none recurred.
  • The mainstay of treatment is complete intracapsular excision preserving the nerve of origin, but for extensive tumour or facial schwannomas, subtotal resection or nerve sacrifice with reconstruction and rehabilitation are considerations.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Medical Audit. Neurilemmoma / diagnosis. Outcome Assessment (Health Care)
  • [MeSH-minor] Adult. Aged. Female. Hospitals, General. Humans. Male. Middle Aged. Retrospective Studies. Risk Factors. Singapore / epidemiology. Time Factors

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  • (PMID = 17483850.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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90. Wang EM, Pan L, Wang BJ, Zhang N, Dong YF, Zhou LF, Dai JZ, Cai PW: [Gamma knife radiosurgery for large trigeminal schwannomas]. Zhonghua Yi Xue Za Zhi; 2005 May 18;85(18):1266-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To evaluate the role of gamma knife (GK) radiosurgery in controlling large trigeminal schwannoma.
  • METHODS: The clinical data of 30 patients suffering from large trigeminal schwannoma with a maximum diameter of 39.0 mm (31.0 to 53.0 mm), who underwent GK radiosurgery, used as the primary treatment modality in 20 patients and used to cure the residuals of tumor after microsurgery in 10 patients, with the maximum irradiation dose to tumor of 25.8 Gy (20.0 to 33.0 Gy) and a tumor margin dose of 12.2 Gy (9.0 to 14.0 Gy), were analyzed respectively.
  • Twenty-nine of the 30 patients were alive, and one patient with malignant trigeminal schwannoma died of tumor progression 36 months after the GK radiosurgery.
  • Two patients' symptoms worsened 5 and 30 months after the GK radiosurgery respectively because of tumor swelling and tumor cyst enlarging.
  • Disappearance of tumor occurred in 4 patients, a marked decrease in tumor volume was observed in 20 patients, three tumors kept unchanged or slightly regressed in volume, and 3 tumors, including that of the patient who died, progressed.
  • The tumor-growth control rate was 90% (27/30).
  • The histopathological findings of this tumor resected 30 months after GK radiosurgery revealed that most of the tumor tissue necrosed and was full of microcysts, the residual tumor cells in peripheral areas underwent hyaline degeneration, and the nuclei showed pyknosis.
  • CONCLUSION: GK may be a good alternative treatment for selective patients suffering from large trigeminal schwannoma with a maximum diameter <or= 40 mm.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery. Trigeminal Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16029613.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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91. Liu WY, Chang CH, Tseng GC: Multiple penile schwannomas. MedGenMed; 2006;8(3):35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The occurrence of penile schwannoma is very rare.
  • The largest tumor causing pain was excised.
  • Pathology was characteristic of benign schwannoma.
  • We recommend that penile schwannomas be excised if the tumors cause pain or are malignant.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery. Penile Neoplasms / pathology. Penile Neoplasms / surgery
  • [MeSH-minor] Adult. Erectile Dysfunction / etiology. Humans. Male. Pain / physiopathology. Penile Erection

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  • [Cites] Int J Urol. 2001 Feb;8(2):87-9 [11240833.001]
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  • (PMID = 17406168.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1781298
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92. Lok KH, Lai L, Yiu HL, Szeto ML, Leung SK: Endosonographic surveillance of small gastrointestinal tumors originating from muscularis propria. J Gastrointestin Liver Dis; 2009 Jun;18(2):177-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with large tumors (maximal diameter > 3 cm), heterogeneous echo pattern, presence of cystic spaces or irregular extra-luminal margin were offered surgery in view of malignant risk.
  • Patients with small tumor and benign EUS features were offered regular EUS surveillance or surgery if they wished.
  • Forty-nine patients had a small tumor and benign EUS features.
  • The histopathological results were low risk gastrointestinal stromal tumor (GIST) in both patients.
  • Three patients (13.0%) showed interval increase in tumor size.
  • Histological examination revealed schwannoma in 2 patients and low risk GIST in 1 patient.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Gastric Mucosa / ultrasonography. Humans. Intestinal Mucosa / ultrasonography. Male. Middle Aged. Retrospective Studies. Time Factors. Young Adult

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  • (PMID = 19565047.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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93. Kim CS, Suh MW: Skull base surgery for removal of temporal bone tumors. Acta Otolaryngol Suppl; 2007 Oct;(558):4-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSION: When selecting the appropriate surgical approach the pathological type of tumor, the physiological status as well as the functional aspects should be considered.
  • Understanding the strengths and weaknesses of each surgical technique and knowledge of the particular tumor biology facilitates selection of the most appropriate surgical approach and a successful outcome.
  • A facial nerve schwannoma was the most common benign intratemporal tumor and a squamous cell carcinoma was the most common malignant tumor.
  • With the facial nerve schwannoma, facial nerve paralysis and hearing loss were the most common presenting complaints; otalgia was the most common presenting symptom for temporal bone cancer.
  • For patients with a glomus tumor, there was a characteristic pulsating tinnitus.
  • A majority of the facial nerve schwannomas were resectable through the transmastoid approach.
  • The infratemporal fossa approach type A was usually required for lower cranial nerve schwannomas and glomus jugulare tumors.
  • [MeSH-minor] Adolescent. Adult. Cerebrospinal Fluid Otorrhea / etiology. Child. Child, Preschool. Cranial Nerve Neoplasms / surgery. Dizziness / etiology. Earache / etiology. Facial Nerve Diseases / surgery. Facial Paralysis / etiology. Female. Glomus Tumor / blood supply. Glomus Tumor / surgery. Hearing Loss / etiology. Hoarseness / etiology. Humans. Infant. Male. Middle Aged. Muscle Weakness. Neurilemmoma / surgery. Retrospective Studies. Tinnitus / etiology. Vertigo / etiology

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  • (PMID = 17882564.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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94. Edelweiss M, Malpica A: Dermatofibrosarcoma protuberans of the vulva: a clinicopathologic and immunohistochemical study of 13 cases. Am J Surg Pathol; 2010 Mar;34(3):393-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dermatofibrosarcoma protuberans (DFSP) is a low-grade sarcoma seldom seen in the vulva with only 29 cases reported.
  • Tumor size ranged from 1.2 to 15 cm (median, 4 cm).
  • Of interest, in 7 of our 13 cases, a variety of diagnoses, such as cellular dermatofibroma, cellular leiomyoma, neurofibroma, low-grade leiomyosarcoma, fibrosarcoma, low-grade malignant schwannoma, desmoplastic melanoma, cellular neurofibroma, and low-grade malignant peripheral nerve sheet tumor were initially considered.
  • [MeSH-major] Biomarkers, Tumor / analysis. Dermatofibrosarcoma / diagnosis. Immunohistochemistry. Skin Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Gynecologic Surgical Procedures. Humans. Middle Aged. Neoplasm Recurrence, Local. Predictive Value of Tests. Radiotherapy, Adjuvant. Reoperation. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20139758.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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95. Gerszten PC, Burton SA: Clinical assessment of stereotactic IGRT: spinal radiosurgery. Med Dosim; 2008;33(2):107-16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At our institution, we have developed a successful multidisciplinary spinal radiosurgery program in which 542 spinal lesions (486 malignant and 56 benign lesions) were treated with a single-fraction radiosurgery technique.
  • The most common benign tumors were neurofibroma (24 cases), schwannoma (13 cases), and meningioma (7 cases).
  • Tumor volume ranged from 0.16 to 298 mL (mean 47 mL).
  • The primary indication for radiosurgery was pain in 326 cases, as a primary treatment modality in 70 cases, for tumor radiographic tumor progression in 65 cases, for post-surgical treatment in 38 cases, for progressive neurological deficit in 35 cases, and as a radiation boost in 8 cases.
  • Long-term tumor control was demonstrated in 90% of lesions treated with radiosurgery as a primary treatment modality and in 88% of lesions treated for radiographic tumor progression.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Equipment Design. Female. Humans. Male. Middle Aged. Stereotaxic Techniques. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18456162.001).
  • [ISSN] 0958-3947
  • [Journal-full-title] Medical dosimetry : official journal of the American Association of Medical Dosimetrists
  • [ISO-abbreviation] Med Dosim
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Yang QC, Ji XH, Shen Y, Han F, Zhang XJ, Liu HB: [Gastrointestinal stromal tumor: a clinicopathological study of 74 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Jan;34(1):6-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gastrointestinal stromal tumor: a clinicopathological study of 74 cases].
  • OBJECTIVE: To explore a simplified and reproducible approach for the diagnosis and morphologic prognostication of gastrointestinal stromal tumor (GIST).
  • METHODS: Eighty-five cases of gastrointestinal mesenchymal tumors including 74 cases of GIST, 8 esophageal smooth muscle tumor, 1 rectal leiomyosarcoma, 1 Schwannoma, and 1 malignant fibrous histiocytoma were studied by histological evaluation along with an immunohistochemistry panel including vimentin, CD117 (c-kit), CD34, SMA, desmin and S-100.
  • Subclassification of GISTs using Fletcher's scheme appears to be simple, reproducible, and correlates well with the clinical behavior of the tumor.
  • [MeSH-minor] Actins / metabolism. Adult. Age Factors. Aged. Aged, 80 and over. Antigens, CD34 / metabolism. Disease-Free Survival. Female. Follow-Up Studies. Gastric Mucosa / pathology. Gastric Mucosa / ultrastructure. Humans. Male. Middle Aged. Neoplasm Invasiveness. Proto-Oncogene Proteins c-kit / metabolism. S100 Proteins / metabolism. Sex Factors. Stomach / pathology

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  • (PMID = 15796874.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / S100 Proteins; 0 / smooth muscle actin, rat; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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97. Sasaki A, Suto T, Nitta H, Shimooki O, Obuchi T, Wakabayashi G: Laparoscopic excision of retroperitoneal tumors: report of three cases. Surg Today; 2010;40(2):176-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The mean tumor size was 4.8 cm.
  • The postoperative pathological diagnosis was schwannoma in one patient and ganglioneuromas in two.
  • Laparoscopic surgical techniques for retroperitoneal tumors are safe, and their use is encouraged when an appropriate diagnosis is made, after exclusion of malignant subtypes.
  • [MeSH-major] Ganglioneuroma / surgery. Laparoscopy / methods. Neurilemmoma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20107961.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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98. Yoshida K, Kawase T, Tomita T, Ogawa K, Kawana H, Yago K, Asanami S: Surgical strategy for tumors located in or extending from the intracranial space to the infratemporal fossa-Advantages of the transcranial approach (zygomatic infratemporal fossa approach) and the indications for a combined transcranial and transcervical approach-. Neurol Med Chir (Tokyo); 2009 Dec;49(12):580-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of mandibular nerve schwannoma, which extended 1 cm below the external orifice of the foramen ovale, was completely removed via the epidural subtemporal approach without zygomatic osteotomy with partial removal of the middle cranial base.
  • The inferior margin of infratemporal tumor could be accessed via the transcranial route with zygomatic or orbitozygomatic osteotomy without complications including facial nerve injury in nine cases, and the lowest level of the infratemporal tumors was approximately 4.5 cm below the outer surface of the middle cranial base.
  • In five of these 9 cases (2 schwannomas, 1 myxoma, 1 chondrosarcoma, and 1 malignant peripheral nerve sheath tumor), the tumors were localized in the infratemporal fossa, and in the other 4 cases (2 meningiomas, 1 glioblastoma, and 1 ameloblastoma), the tumors extended to both the intracranial space and the infratemporal fossa.
  • In two cases (recurrent jugular schwannoma and mandibular osteosarcoma), a combined transcranial and transcervical approach (mandibular swing approach) was essential, because the resection line of the lower margin was too far from the middle cranial base.
  • [MeSH-minor] Adult. Aged. Cranial Nerve Neoplasms / pathology. Cranial Nerve Neoplasms / radiography. Cranial Nerve Neoplasms / surgery. Cranial Nerves / anatomy & histology. Cranial Nerves / pathology. Cranial Nerves / surgery. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / pathology. Meningioma / radiography. Meningioma / surgery. Middle Aged. Neck / anatomy & histology. Neck / surgery. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Orbit / anatomy & histology. Orbit / surgery. Osteotomy / methods. Postoperative Complications / prevention & control. Retrospective Studies. Sarcoma / pathology. Sarcoma / radiography. Sarcoma / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / radiography. Skull Base Neoplasms / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult. Zygoma / anatomy & histology. Zygoma / surgery

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  • (PMID = 20035132.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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99. Stark AM, Maslehaty H, Hugo HH, Mahvash M, Mehdorn HM: Glioblastoma of the cerebellum and brainstem. J Clin Neurosci; 2010 Oct;17(10):1248-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor.
  • Because of its rarity and the non-specific radiological features of iGB, it can easily be misdiagnosed as a brain metastasis, ependymoma or even as a benign lesion such as vestibular schwannoma or meningioma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20619657.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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100. Smith AB, Rushing EJ, Smirniotopoulos JG: Pigmented lesions of the central nervous system: radiologic-pathologic correlation. Radiographics; 2009 Sep-Oct;29(5):1503-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented lesions of the central nervous system (CNS) are a diverse group of entities that run the gamut from benign to malignant.
  • Pigmented lesions include primary melanocytic lesions of the CNS and metastatic melanoma, as well as other CNS neoplasms that may undergo melanization, including schwannoma, medulloblastoma, and some gliomas.
  • Primary melanocytic lesions of the CNS arise from melanocytes located within the leptomeninges, and this group includes diffuse melanocytosis and meningeal melanomatosis (seen in neurocutaneous melanosis), melanocytoma, and malignant melanoma.
  • Absence of a known primary malignant melanoma helps in the differential diagnosis, but an occult primary lesion outside the CNS must be sought and excluded.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Infant. Male. Middle Aged

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  • [Copyright] (c) RSNA, 2009.
  • (PMID = 19755608.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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