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1. Xiong Z, Cao Y, Guo D, Ye F, Lei T: Expression of EGFR and LRIG-1 in human trigeminal neurinoma. J Huazhong Univ Sci Technolog Med Sci; 2006;26(1):86-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It was suggested that LRIG-1 might inhibit the malignant differentiation and proliferation of the trigeminal neurinoma possibly by the negative feedback loop of EGFR.
  • [MeSH-major] Cranial Nerve Neoplasms / metabolism. Membrane Glycoproteins / biosynthesis. Neurilemmoma / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Trigeminal Nerve Diseases / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 16711015.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / LRIG1 protein, human; 0 / Membrane Glycoproteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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2. Hamada K, Ueda T, Higuchi I, Inoue A, Tamai N, Myoi A, Tomita Y, Aozasa K, Yoshikawa H, Hatazawa J: Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging. Skeletal Radiol; 2005 Jan;34(1):52-7
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  • [Title] Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging.
  • We present two cases of peripheral nerve schwannoma which showed an increased accumulation of 2-deoxy-[(18)F] fluoro-D-glucose (FDG) in the tumors on positron emission tomography (PET) imaging acquired at both 1 h (early phase) and 2 h (delayed phase) after FDG injection.
  • We set the maximum standardized uptake value (SUV max) with a cut-off point of 3.0 to distinguish benign and malignant lesions.
  • Although the mechanism responsible for the increased FDG uptake in benign schwannomas remains unknown, we discuss our findings in the context of tumor cellularity and briefly review other studies on the subject.
  • [MeSH-major] Fluorodeoxyglucose F18. Neurilemmoma / diagnostic imaging. Peripheral Nervous System Neoplasms / diagnostic imaging. Positron-Emission Tomography / methods. Radiopharmaceuticals
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnostic imaging. Humans. Muscle Neoplasms / diagnostic imaging. Retroperitoneal Neoplasms / diagnostic imaging

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  • (PMID = 15480645.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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3. Domanski HA, Akerman M, Rissler P, Gustafson P: Fine-needle aspiration of soft tissue leiomyosarcoma: an analysis of the most common cytologic findings and the value of ancillary techniques. Diagn Cytopathol; 2006 Sep;34(9):597-604
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  • An unequivocal, malignant diagnosis was rendered by FNAC in 78 cases; 74 tumors were diagnosed as sarcoma, of which 31 as LMS or suspicion of LMS.
  • In addition, three smears were labeled as malignant tumor, one as carcinoma metastasis, and three as neurilemmoma.
  • On reevaluation, the diagnostic smears in most cases contained tumor cell fascicles with an admixture of dispersed cells or stripped nuclei.
  • Thus, most high-grade LMSs have cytologic features that allow diagnosis of sarcoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Reproducibility of Results

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16900474.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Santaella Y, Borrego I, López J, Ortiz MJ, Vázquez R: [18-FDG-PET in a case of recurrent malignant schwannoma]. Rev Esp Med Nucl; 2005 Mar-Apr;24(2):127-30
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  • [Title] [18-FDG-PET in a case of recurrent malignant schwannoma].
  • [Transliterated title] Diagnóstico de recurrencia mediante FDG-PET en un caso clínico de schwannoma maligno.
  • The peripheral nerve sarcoma, also called malignant schwannoma, is originally a soft tissue sarcoma.
  • It is mainly located in the peripheral sheath nerve of the limbs and usually infiltrates the nerve fibres.
  • We present the case of a thirty year old woman with a malignant schwannoma in her left leg sciatic nerve who had been treated on several occasions.
  • PET can be a useful technique to detect recurrence for this kind of tumor, mainly in patients who have been previously radiated when the MRI is insufficient to perform a differential diagnosis between postirradiation fibrosis and tumoral recurrence, allowing for suitable therapeutic management of the patient.
  • [MeSH-major] Fluorodeoxyglucose F18. Neurilemmoma / radionuclide imaging. Peripheral Nervous System Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Sciatic Neuropathy / radionuclide imaging
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 15745683.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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5. Wasa J, Nishida Y, Suzuki Y, Tsukushi S, Shido Y, Hosono K, Shimoyama Y, Nakamura S, Ishiguro N: Differential expression of angiogenic factors in peripheral nerve sheath tumors. Clin Exp Metastasis; 2008;25(7):819-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of angiogenic factors in peripheral nerve sheath tumors.
  • It is difficult to differentiate some malignant peripheral nerve sheath tumors (MPNST) from benign peripheral nerve sheath tumors (BPNST) histologically, and to predict the clinical outcome of patients with MPNST.
  • In this study, the expression of VEGF and MVD were evaluated immunohistochemically in 22 cases of MPNST, 14 of neurofibroma and 19 of schwannoma and correlation of the staining grade of VEGF or MVD and the various clinical factors were analyzed, and statistically evaluated.
  • Statistically higher positive staining for VEGF was observed in MPNST compared to neurofibroma (P=0.004) and schwannoma (P<0.001).
  • Even low grade MPNST showed higher VEGF positive staining than neurofibroma.
  • Moreover, high VEGF expression statistically correlated with the poor prognosis of the patients with MPNST (P=0.015).
  • Although MVD in MPNST was significantly higher than that in neurofibroma (P=0.038) and schwannoma (P<0.001), MVD could not predict the prognosis of the patients with MPNST.
  • Although VEGF mRNA expression tended to be higher in MPNST compared to neurofibroma, the difference was not significant.
  • Levels of VEGF protein expression serve as a novel diagnostic and prognostic tools for peripheral nerve sheath tumors.
  • [MeSH-major] Nerve Sheath Neoplasms / chemistry. Vascular Endothelial Growth Factor A / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neurilemmoma / blood supply. Neurilemmoma / chemistry. Neurofibroma / blood supply. Neurofibroma / chemistry. RNA, Messenger / analysis

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  • (PMID = 18679811.001).
  • [ISSN] 0262-0898
  • [Journal-full-title] Clinical & experimental metastasis
  • [ISO-abbreviation] Clin. Exp. Metastasis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A
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6. Kaehler KC, Russo PA, Katenkamp D, Kreusch T, Neuber K, Schwarz T, Hauschild A: Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature. Melanoma Res; 2008 Dec;18(6):438-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature.
  • Melanocytic schwannoma is a rare soft-tissue tumor, which arises most commonly in the paraspinal sympathetic chain.
  • To date, only 17 cases of a cutaneous and subcutaneous melanocytic schwannoma have been reported.
  • Three cases of cutaneous melanocytic schwannoma, diagnosed in our institution are reported.
  • For further literature overview we performed a search on Medline using the terms 'melanocytic schwannoma' or 'melanotic schwannoma' or 'Carney complex' combined with 'skin' or 'cutaneous', for the period 1970-2007.
  • Seventeen patients were described to have melanocytic schwannoma of the skin or subcutaneous tissues.
  • In contrast, none of the reported cases of cutaneous or subcutaneous melanocytic schwannomas was characterized by a malignant course.
  • The differential diagnosis, especially with regard to malignant melanoma, is made by histology and by its clinical course, which differs from melanoma in its tendency to recur at the site of excision and slow rate of growth.
  • Commonly misdiagnosed as melanoma, this tumor reveals insights into the origin of both melanocytes and Schwann cells.
  • It is likely that the biological bases for melanoma and melanocytic schwannoma differ.
  • It is necessary to differentiate this tumor from melanoma because of the differing prognosis and the association of melanocytic schwannoma with the Carney complex.
  • [MeSH-major] Melanoma / diagnosis. Neurilemmoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Subcutaneous Tissue / pathology

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  • (PMID = 19011514.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 28
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7. Schmitz KJ, Unkel C, Grabellus F, Baba HA, Dirsch O, Neumann A: Melanotic schwannoma of the neck mimicking a malignant melanoma. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):182-5
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  • [Title] Melanotic schwannoma of the neck mimicking a malignant melanoma.
  • A fine-needle aspiration biopsy performed elsewhere led to the diagnosis of malignant melanoma.
  • Diagnostic exstirpation of the cervical tumor resulted in the intraoperative diagnosis of a malignant melanoma.
  • Subsequent pathological examination including ultrastructural analysis allowed the revision of the diagnosis to that of melanotic schwannoma, a rare, pigmented nerve sheath tumor.
  • With regard to prognostic and therapeutic issues, it is necessary to differentiate these tumors from the more common metastatic malignant melanoma.
  • [MeSH-major] Melanoma / diagnosis. Neurilemmoma / pathology. Pharyngeal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans. Treatment Outcome. Ultrasonography

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  • (PMID = 15133690.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Yeh CJ, Chuang WY, Huang ST, Jung SM: Schwannoma of the penis: a report of two cases. Chang Gung Med J; 2007 Nov-Dec;30(6):555-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannoma of the penis: a report of two cases.
  • Schwannomas are benign nerve sheath tumors, which can occur sporadically or in patients with neurofibromatosis.
  • The first patient was a 26-year-old man presenting with a 2 x 2 cm, slowly growing, painless tumor on the dorsal penile shaft.
  • Both patients received simple tumor excision, and neither experienced tumor recurrence.
  • Notably, multiple tumors are present in 30% of penile schwannoma cases, whereas most schwannomas at other locations present as a single tumor.
  • No reported patients had malignant transformation, but two had tumor recurrence 4 months and 7 years after excision.
  • [MeSH-major] Neurilemmoma / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 18350739.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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9. Zhao BQ, Dong AQ, Chen RK: [Diagnosis and surgical treatment of giant intrathoracic solid tumors]. Zhonghua Zhong Liu Za Zhi; 2008 Sep;30(9):709-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During the follow-up of 1 to 22 years, all patients with benign tumors were still alive, but the patients with malignant tumors had a mean survival time of only 2.1 years.
  • Even though a tumor can not be completely resected, satisfied results could still be achieved if combined with postoperative radiotherapy.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Lymphoma / diagnosis. Lymphoma / pathology. Lymphoma / surgery. Male. Middle Aged. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / surgery. Pulmonary Edema / etiology. Survival Rate. Tumor Burden

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  • (PMID = 19173918.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Chan PT, Tripathi S, Low SE, Robinson LQ: Case report--ancient schwannoma of the scrotum. BMC Urol; 2007;7:1
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  • [Title] Case report--ancient schwannoma of the scrotum.
  • BACKGROUND: Scrotal schwannoma is a rare neoplasm and poses a diagnostic challenge to urologists.
  • This article describes a rare case of ancient scrotal schwannoma and reviews the current modality of investigation and treatment of this tumour.
  • Surgical excision was undertaken and histology was an ancient schwannoma of the scrotum.
  • CONCLUSION: Schwannoma is a benign encapsulating neoplasm with an overall low incidence, occurring mostly in the head and neck region and seldom in the scrotum.
  • Variations of schwannoma such as cellular, ancient, glandular and epithelioid are observed based on the appearances.
  • Ancient schwannoma exhibits pleomorphism without mitosis as the result of cellular degeneration, which can lead to an erroneous diagnosis of malignancy.
  • Malignant change is exceedingly rare.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Genital Neoplasms, Male / therapy. Neurilemmoma / diagnosis. Neurilemmoma / therapy
  • [MeSH-minor] Adult. Humans. Male. Scrotum

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  • (PMID = 17244372.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
  • [Other-IDs] NLM/ PMC1783662
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11. Knight DM, Birch R, Pringle J: Benign solitary schwannomas: a review of 234 cases. J Bone Joint Surg Br; 2007 Mar;89(3):382-7
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  • In these, a nerve repair was performed in 18 and treatment for pain or paralysis was offered to another 14.
  • No case of malignant transformation was seen.
  • [MeSH-major] Neurilemmoma / surgery. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Bone Neoplasms / pathology. Bone Neoplasms / physiopathology. Bone Neoplasms / surgery. Brachial Plexus Neuropathies / pathology. Brachial Plexus Neuropathies / physiopathology. Brachial Plexus Neuropathies / surgery. Child. Female. Humans. Male. Middle Aged. Muscle Neoplasms / pathology. Muscle Neoplasms / physiopathology. Muscle Neoplasms / surgery. Pain / physiopathology. Postoperative Complications. Treatment Outcome

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  • (PMID = 17356155.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Nabeshima K, Iwasaki H, Nishio J, Koga K, Shishime M, Kikuchi M: Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential. Anticancer Res; 2006 Mar-Apr;26(2B):1359-67
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  • [Title] Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential.
  • However, their roles in peripheral nerve sheath tumors (PNSTs) have rarely been investigated.
  • MATERIALS AND METHODS: In this study, the immunohistochemical expression of 6 MMPs, their 3 inhibitors and emmprin, an MMP inducer, was examined in 14 schwannomas, 14 neurofibromas and 12 malignant peripheral nerve sheath tumors (MPNSTs) in relation to malignant potentials.
  • Moreover, the expression patterns of MMP-1 and gelatinase B (MMP-9) could divide PNSTs into two groups: schwannoma versus neurofibroma/MPNST.
  • CONCLUSION: These results suggest that emmprin and MT1-MMP may be malignant potential-related proteins in PNSTs, and that MMP-1 and 9 may help differentiation between schwannoma and neurofibroma, especially in their plexiform types.
  • [MeSH-major] Antigens, CD147 / biosynthesis. Matrix Metalloproteinases / biosynthesis. Nerve Sheath Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Immunohistochemistry. Isoenzymes / biosynthesis. Male. Matrix Metalloproteinases, Membrane-Associated. Middle Aged. Neurilemmoma / enzymology. Neurilemmoma / metabolism. Neurilemmoma / pathology. Neurofibroma / enzymology. Neurofibroma / metabolism. Neurofibroma / pathology

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  • (PMID = 16619545.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / BSG protein, human; 0 / Isoenzymes; 136894-56-9 / Antigens, CD147; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases, Membrane-Associated
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13. Wan B, Wang L, Zhu Y, Ma S, Xie W: [Clinical analysis of 33 cases of neurilemmomas of the head and neck]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Sep;21(17):794-5
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  • One case with malignant tumor were died.
  • CONCLUSION: Tumor resection is still the most effective treatment available for patients with neurilemmomas of the head and neck.
  • Resection of tumor should be performed as soon as possible with careful protection of the function of the nerve.
  • Extensive resection should be performed to treat malignant tumors.
  • [MeSH-major] Head and Neck Neoplasms. Neurilemmoma
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 17993019.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Andrade ES, Filho JR, Rocha NS, Neto IC, Camargo IB: Isolated intra-oral granular cell tumor: report of two cases and review of the literature. Acta Odontol Latinoam; 2010;23(2):99-104
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  • [Title] Isolated intra-oral granular cell tumor: report of two cases and review of the literature.
  • Granular cell tumor (GCT) is a relatively uncommon lesion occurring in almost any part of the body, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most GCTs are benign.
  • The tumor generally occurs in middle-aged or older adults.
  • Differential diagnoses include fibrous hyperplasia, minor salivary gland tumor condyloma acuminatum and neurilemmoma.
  • The main clinical pathology and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Humans. Male

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  • (PMID = 21053681.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Argentina
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15. Salla JT, Johann AC, Garcia BG, Aguiar MC, Mesquita RA: Retrospective analysis of oral peripheral nerve sheath tumors in Brazilians. Braz Oral Res; 2009 Jan-Mar;23(1):43-8
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  • [Title] Retrospective analysis of oral peripheral nerve sheath tumors in Brazilians.
  • Traumatic neuroma, neurofibroma, neurilemmoma, palisaded encapsulated neuroma and malignant peripheral nerve sheath tumor (MPNST) are peripheral nerve sheath tumors and present neural origin.
  • The goal of this study was to describe the epidemiological data of oral peripheral nerve sheath tumors in a sample of the Brazilian population.
  • Lesions diagnosed as peripheral nerve sheath tumors were submitted to morphologic and to immunohistochemical analyses.
  • Thirty-five oral peripheral nerve sheath tumors were found, representing 0.16% of all lesions archived in the Oral Pathology Service.
  • Neurilemmoma (4 cases) was more commonly observed in the buccal mucosa.
  • Malignant peripheral nerve sheath tumors (3 cases) occurred in the mandible, palate, and tongue.
  • The data confirmed that oral peripheral nerve sheath tumors are uncommon in the oral region, with some lesions presenting a predilection for a specific gender or site.
  • This study may be useful in clinical dentistry and oral pathology practice and may be used as baseline data regarding oral peripheral nerve sheath tumors in other populations.
  • [MeSH-major] Mouth Neoplasms / epidemiology. Nerve Sheath Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Brazil / epidemiology. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Retrospective Studies. S100 Proteins / analysis. Young Adult

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  • (PMID = 19488471.001).
  • [ISSN] 1807-3107
  • [Journal-full-title] Brazilian oral research
  • [ISO-abbreviation] Braz Oral Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / S100 Proteins
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16. Benz MR, Czernin J, Dry SM, Tap WD, Allen-Auerbach MS, Elashoff D, Phelps ME, Weber WA, Eilber FC: Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer; 2010 Jan 15;116(2):451-8
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  • [Title] Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign.
  • BACKGROUND: Correct pretreatment classification is critical for optimizing diagnosis and treatment of patients with peripheral nerve sheath tumors (PNSTs).
  • The aim of this study was to evaluate whether F18-fluorodeoxyglucose positron emission tomography (FDG PET) can differentiate malignant (MPNST) from benign PNSTs.
  • METHODS: Thirty-four adult patients presenting with PNST who underwent a presurgical FDG PET/computed tomography (CT) scan between February 2005 and November 2008 were included in the study.
  • Tumors were characterized histologically, by FDG maximum standardized uptake value (SUV(max) [g/mL]), and by CT size (tumor maximal diameter [cm]).
  • The accuracy of FDG PET for differentiating MPNSTs from benign PNSTs (neurofibroma and schwannoma) was evaluated by receiver operating characteristic (ROC) curve analysis.
  • SUV(max) was significantly higher in MPNST compared with benign PNST (12.0 +/- 7.1 vs 3.4 +/- 1.8; P < .001).
  • By ROC curve analysis, SUV(max) reliably differentiated between benign and malignant PNSTs (area under the ROC curve of 0.97).
  • Given the difficulties in clinically evaluating PNST and in distinguishing benign PNST from MPNST, FDG PET imaging should be used for diagnostic intervention planning and for optimizing treatment strategies.

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  • (PMID = 19924789.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA086306; United States / NCI NIH HHS / CA / 5 P50 CA086306
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ NIHMS324300; NLM/ PMC3188986
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17. Ziadi A, Saliba I: Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review. Auris Nasus Larynx; 2010 Oct;37(5):539-45
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  • [Title] Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review.
  • OBJECTIVES: The incidence of malignant peripheral nerve sheath tumor (MPNST) is approximately 0.001%.
  • (1) to review all cases of intracranial MPNST described in the literature, (2) to highlight the suspicion of intracranial MPNST, (3) to identify the gross pathology, the histopathology, the immunohistochemistry, (4) to discuss the differential diagnosis, the treatment, the recurrence rate, the follow-up, the incidence of metastasis and the prognosis.
  • We used the following Keywords: "malignant peripheral nerve sheath tumor", "cranial nerve", "neurosarcoma", "malignant schwannoma", "neurofibroma", "malignant neurofibroma" and "nerve tumor".
  • We considered cases where MPNST involved an intracranial cranial nerve.
  • RESULTS: We identified 32 cases of cranial MPNST including our case.
  • Most cases are developed sporadically (50%), 31% arise from a malignant transformation of schwannoma and 19% from a neurofibroma.
  • The cranial nerve VIII is the most involved (15/32), followed by the Vth (10/32) and the VIIth (5/32).
  • MPNST will strongly express protein S-100 and collagen IV-laminin.
  • 13 cases were treated with radiotherapy for tumor recurrence and metastasis.
  • CONCLUSION: MPNST of cranial nerves are very rare.
  • In neurofibroma, even though MPNST is mainly associated to type 1, we should keep in mind its association to NF2.
  • Inaccessibility of cranial MPNST may explain the subtotal resection and thus the poor prognosis.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Transformation, Neoplastic / pathology. Child. Child, Preschool. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / radiotherapy. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / radiotherapy. Neurofibroma / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / radiotherapy. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / radiotherapy. Neurofibromatosis 2 / surgery. Radiotherapy, Adjuvant. Spinal Neoplasms / mortality. Spinal Neoplasms / pathology. Spinal Neoplasms / secondary. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20399579.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
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18. Rong BG, Chen WL, Ding YP, Xie G, Chen Y, Wang TD: [Surgical approaches to the skull base neoplasms]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Apr;40(4):291-4
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  • Eleven surgical approaches including midfacial degloving, frontal coronal discission, nasal eversion, maxillary swing, partial maxillary resection, total resection of orbit, mandibular swing, combination of front, temple, preauricular, post aureum, neck, and transoral approaches were used to resect the tumor which involved fossae pterygopalatine, paranasal sinuses, nasopharynx, antero, meso and posterobasilar region, lobi frontalis and lobi temporalis of cerebrum.
  • In 29 patients with benign tumor including 11 cases of meningioma, 3 cases of chondroma, 1 case of hemangio-meningioma, 1 case of cavernous hemangioma, 2 cases of osteodysplasia fibromas, 9 cases of neurofibroma, 1 case of glomus jugular tumor, 1 case of neurilemmoma, 19 have survived over 5 years and the longest one has survived over 8 years.
  • For 50 patients with malignant tumor including 3 cases of well-differentiated squamous cell carcinoma, 17 cases of moderately differentiated squamous cell carcinoma, 11 cases of poorly differentiated squamous cell carcinoma, 1 case of undifferentiated carcinoma, 2 cases of chondrosarcoma, 5 cases of canceration of papilloma, 2 cases of adenocarcinoma, 1 case of esthesioneuroblastoma, 2 cases of malignant fibrohistiocytoma, 1 case of fibrosarcoma, 2 cases of malignant mixed tumour, 3 cases of sarcoma survival rates of 3 and 5 years were 59.2% (29/49), 38.5% (10/26) respectively.
  • CONCLUSION: In order to resect the tumor completely and reduce the complication and malformation as far as possible, different surgical approaches must be designed according to the pathological changes characters and involved area,and the surgeon should select the shortest approach, avoid to damage the important neurovascular structure, and resect the tumor through the natural anatomy space by the shelter incision.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16008265.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Braunschweig F, Kramer MF, Assmann G, Arbogast S, Leunig A: [Schwannoma of the nasal cavity: a case report]. HNO; 2007 Dec;55(13):1013-6
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  • [Title] [Schwannoma of the nasal cavity: a case report].
  • It is very important to distinguish between schwannoma and primary benign neurofibroma.
  • Neurofibromas are lesions having the possibility for malignant transformation and recurrence.
  • A case of schwannoma in the nasal cavity is reported, and the diagnostic and therapeutic procedures, as well as recommendations from the literature, are described.
  • The histological and immunohistochemical features are discussed in detail to draw a distinction between schwannoma and neurofibroma.
  • In cases of intranasal and paranasal lesions, the existence of a schwannoma must be considered.
  • Differentiating between schwannoma and neurofibroma is important for estimating the risk of malignant transformation and recurrence.
  • [MeSH-major] Nasal Cavity / pathology. Neurilemmoma / pathology. Neurofibroma / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 17874054.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 22
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20. Miyamoto J, Tatsuzawa K, Owada K, Kawabe T, Sasajima H, Mineura K: Usefulness and limitations of fluorine-18-fluorodeoxyglucose positron emission tomography for the detection of malignancy of orbital tumors. Neurol Med Chir (Tokyo); 2008;48(11):495-9; discussion 499
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  • Twelve patients with 13 orbital tumors underwent [18F]FDG PET followed by biopsy or tumor removal via a transcranial approach.
  • The accumulation ratio between the tumor and the contralateral normal tissue (T/N ratio) was calculated for 10 of the 13 lesions.
  • The T/N ratio in benign lesions was compared with that in malignant tumors.
  • Histological examination identified 7 lesions as malignant: anaplastic astrocytoma of the optic nerve in 1 patient, which recurred as glioblastoma of the optic nerve, malignant lymphoma of mucosa-associated lymphoid tissue type in 1 patient, malignant melanoma in 1 patient, adenoid cystic carcinoma in 2 patients, and adenocarcinoma (unknown origin) in 1 patient.
  • The T/N ratio was 1.06 +/- 0.03 (mean +/- standard deviation) in benign tumors, and significantly higher at 1.81 +/- 0.27 in malignant tumors (p = 0.0027).
  • [18F]FDG PET can determine the malignancy of orbital tumors, but cannot distinguish malignant tumor from inflammatory disease such as pseudotumor.
  • [MeSH-major] Optic Nerve Neoplasms / radionuclide imaging. Orbital Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adolescent. Adult. Aged. Astrocytoma / radionuclide imaging. Carcinoma, Adenoid Cystic / radionuclide imaging. Diagnosis, Differential. Female. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Glioblastoma / radionuclide imaging. Hemangioma, Cavernous, Central Nervous System / radionuclide imaging. Humans. Lymphoma, B-Cell, Marginal Zone / radionuclide imaging. Male. Melanoma / radionuclide imaging. Middle Aged. Neurilemmoma / radionuclide imaging. Orbital Pseudotumor / radionuclide imaging. Radiopharmaceuticals. Young Adult

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  • (PMID = 19029776.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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21. Wang W, Montgomery E, Epstein JI: Benign nerve sheath tumors on urinary bladder biopsy. Am J Surg Pathol; 2008 Jun;32(6):907-12
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  • [Title] Benign nerve sheath tumors on urinary bladder biopsy.
  • Benign nerve sheath tumors (schwannoma and neurofibroma) involving the urinary bladders are rare with only case reports and limited series.
  • Both cases with schwannoma had only bladder involvement.
  • Neither recurrence nor malignant transformation was demonstrated on follow-up.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurilemmoma / pathology. Neurofibroma / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Child. Child, Preschool. Female. Humans. Male. Middle Aged

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  • (PMID = 18425043.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Cho YJ, Won JB, Byeon SH, Yang WI, Koh HJ, Kwon OW, Lee SC: A choroidal schwannoma confirmed by surgical excision. Korean J Ophthalmol; 2009 Mar;23(1):49-52
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  • [Title] A choroidal schwannoma confirmed by surgical excision.
  • Schwannomas rarely present as intraocular tumors and are often misdiagnosed as malignant melanoma.
  • We describe a choroidal schwannoma confirmed by sclerouvectomy.
  • Histologically, the tumor was composed of a mixture of cellular solid components (Antoni A) and loose myxoid components (Antoni B).
  • The tumor was eventually diagnosed as a schwannoma.
  • In the case of atypical findings for a malignant melanoma, a benign neoplasm should be included in the differential diagnosis.
  • We are unaware of previous reports in which a choroidal schwannoma was diagnosed by surgical excision.
  • [MeSH-major] Choroid / pathology. Choroid Neoplasms / diagnosis. Eye Enucleation / methods. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • [Cites] Ophthalmologica. 2000;214(2):156-60 [10720924.001]
  • [Cites] Ophthalmology. 1981 Dec;88(12):1322-9 [7322483.001]
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  • (PMID = 19337481.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2655748
  • [Keywords] NOTNLM ; Enucleation / Schwannoma / Sclerouvectomy
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23. Stojanovic MP, Radojkovic M, Jeremic LM, Zlatic AV, Stanojevic GZ, Jovanovic MA, Kostov MS, Katic VP: Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection. World J Gastroenterol; 2010 Jan 7;16(1):119-22
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  • [Title] Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection.
  • Pancreatic schwannoma is a very uncommon tumor of the pancreas, with only 27 cases reported.
  • Most pancreatic schwannomas are benign, with only four malignant tumors reported.
  • We describe a case of giant malignant schwannoma of the pancreatic body and tail, which involved the transverse colon.
  • The tumor was treated successfully with en bloc distal splenopancreatectomy and colon resection.
  • This is believed to be the first reported radical operation for malignant schwannoma of the pancreatic body, with infiltration of the transverse colon, with excellent long-term results.
  • In the case of the benign tumors, local excision is adequate, but in the case of malignant schwannoma, oncological standards must be fulfilled.
  • [MeSH-major] Colectomy. Colon / surgery. Neurilemmoma / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Biopsy. Female. Humans. Lymph Node Excision. Neoplasm Invasiveness. Splenectomy. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • [Cites] Surg Today. 1999;29(10):1093-7 [10554337.001]
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  • (PMID = 20039458.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2799907
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24. Ying YL, Zimmer LA, Myers EN: Base of tongue schwannoma: a case report. Laryngoscope; 2006 Jul;116(7):1284-7
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  • [Title] Base of tongue schwannoma: a case report.
  • Both malignant and benign lesions may be found on the base of the tongue, including metastasis from other sites.
  • Here, we report a case of a 26-year-old woman with a schwannoma in the base of tongue removed through a suprahyoid pharyngotomy approach.
  • The biology and pathology of schwannoma in the oral cavity are discussed.
  • [MeSH-major] Neurilemmoma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging

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  • (PMID = 16826078.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Wang EM, Pan L, Wang BJ, Zhang N, Dong YF, Zhou LF, Dai JZ, Cai PW: [Gamma knife radiosurgery for large trigeminal schwannomas]. Zhonghua Yi Xue Za Zhi; 2005 May 18;85(18):1266-9
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  • OBJECTIVE: To evaluate the role of gamma knife (GK) radiosurgery in controlling large trigeminal schwannoma.
  • METHODS: The clinical data of 30 patients suffering from large trigeminal schwannoma with a maximum diameter of 39.0 mm (31.0 to 53.0 mm), who underwent GK radiosurgery, used as the primary treatment modality in 20 patients and used to cure the residuals of tumor after microsurgery in 10 patients, with the maximum irradiation dose to tumor of 25.8 Gy (20.0 to 33.0 Gy) and a tumor margin dose of 12.2 Gy (9.0 to 14.0 Gy), were analyzed respectively.
  • Twenty-nine of the 30 patients were alive, and one patient with malignant trigeminal schwannoma died of tumor progression 36 months after the GK radiosurgery.
  • Two patients' symptoms worsened 5 and 30 months after the GK radiosurgery respectively because of tumor swelling and tumor cyst enlarging.
  • Disappearance of tumor occurred in 4 patients, a marked decrease in tumor volume was observed in 20 patients, three tumors kept unchanged or slightly regressed in volume, and 3 tumors, including that of the patient who died, progressed.
  • The tumor-growth control rate was 90% (27/30).
  • The histopathological findings of this tumor resected 30 months after GK radiosurgery revealed that most of the tumor tissue necrosed and was full of microcysts, the residual tumor cells in peripheral areas underwent hyaline degeneration, and the nuclei showed pyknosis.
  • CONCLUSION: GK may be a good alternative treatment for selective patients suffering from large trigeminal schwannoma with a maximum diameter <or= 40 mm.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery. Trigeminal Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16029613.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Inokuchi T, Takiuchi H, Moriwaki Y, Ka T, Takahashi S, Tsutsumi Z, Shima H, Hirota S, Yamamoto T: Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings. Magn Reson Imaging; 2006 Dec;24(10):1389-93
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  • [Title] Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings.
  • A laparoscopic adrenalectomy was performed under the suspicion of a malignant tumor, such as a malignant fibrous histiocytoma.
  • Pathologic findings indicated a retroperitoneal ancient schwannoma of two histologic types: Antoni A and Antoni B.
  • We considered that elucidation of the characteristic features of a schwannoma would provide helpful preoperative information for diagnosis.
  • [MeSH-major] Magnetic Resonance Imaging. Neurilemmoma / pathology. Retroperitoneal Neoplasms / pathology. Tomography, X-Ray Computed
  • [MeSH-minor] Abdomen / ultrasonography. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radiography. Adrenal Gland Neoplasms / ultrasonography. Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17145411.001).
  • [ISSN] 0730-725X
  • [Journal-full-title] Magnetic resonance imaging
  • [ISO-abbreviation] Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Fisher BJ, Dennis KE: Malignant epithelioid cranial nerve sheath tumor: case report of a radiation response. J Neurooncol; 2006 Jun;78(2):173-7
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  • [Title] Malignant epithelioid cranial nerve sheath tumor: case report of a radiation response.
  • Malignant epithelioid nerve sheath tumors (MESs) especially those involving intracranial cranial nerves are rare and thought to be radioresistant.
  • A 41-year-old man with progressive left facial weakness underwent an MRI that disclosed an enhancing lesion involving both V3 cranial nerve and the distal VIIth nerve.
  • Biopsy confirmed a malignant epithelioid schwannoma.
  • The tumor was resected but residual tumor was present at the cut end of the infraorbital nerve, within the oral cavity and at the brainstem.
  • Tumor was controlled for 38 months and then radiographic recurrence was resected from the infratemporal fossa outside the irradiated field.A new primary MES tumor developed at 69 months at the C1/C2 root levels at the lower edge of the previously irradiated field.
  • It was subtotally resected but by 77 months residual tumor had grown inferiorly down to C5 so this area was re-irradiated with a complicated 7-field approach to spare spinal cord.
  • Initially the tumor responded but ultimately progressed posteriorly where radiation dose was limited by spinal cord tolerance.
  • New involvement of the Xth cranial nerve was noted.
  • The long-term control of the original tumor despite positive margins argues for the use of radiotherapy in the treatment of these tumors.
  • [MeSH-major] Cranial Nerve Neoplasms / radiotherapy. Facial Nerve Diseases / radiotherapy. Nerve Sheath Neoplasms / radiotherapy. Neurilemmoma / radiotherapy. Trigeminal Nerve Diseases / radiotherapy
  • [MeSH-minor] Adult. Facial Nerve / pathology. Facial Nerve / surgery. Humans. Male. Radiotherapy Dosage. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / surgery

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  • (PMID = 16557352.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Waldron JS, Tihan T, Parsa AT: Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma. Neurosurgery; 2006 Oct;59(4):E939-40; discussion E940
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  • [Title] Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma.
  • OBJECTIVE: The authors present a report of a solitary fibrous tumor (SFT) arising from the intradural component of the VIth cranial nerve as it travels through the prepontine cistern.
  • In this study, the authors define a subpopulation of SFTs that seem to arise directly from nerve, rather than meninges, and clinically mimic the appearance of a schwannoma.
  • The patient was then taken to the operating room by a combined neurosurgical and ear, nose, and throat team, where the patient underwent a retrolabyrinthine/subtemporal craniotomy for tumor resection.
  • During resection of the prepontine component, the tumor was identified as originating from the left Cranial Nerve VI as it traversed through the prepontine cistern.
  • Resection of the tumor component involving the cavernous sinus and Meckel's cave was deferred for follow-up treatment with intensity-modulated radiation therapy.
  • This patient had an SFT masquerading as a VIth cranial nerve schwannoma.
  • Although the natural history of SFTs in the CNS is not completely understood, correct diagnosis is important, given the rate of recurrence found in the more common pleural-based SFT and examples of CNS SFTs with malignant features.
  • [MeSH-major] Abducens Nerve. Cranial Nerve Neoplasms / pathology. Fibroma / pathology. Neurilemmoma / pathology. Pons
  • [MeSH-minor] Adult. Cerebral Angiography. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Radiotherapy, Adjuvant

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  • (PMID = 17038929.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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29. Messing-Jünger AM, Riemenschneider MJ, Reifenberger G: A 21-year-old female with a third ventricular tumor. Brain Pathol; 2006 Jan;16(1):87-8, 93
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  • [Title] A 21-year-old female with a third ventricular tumor.
  • Intraoperatively, the tumor showed a close relationship to the choroid plexus of the third ventricle.
  • Histopathology revealed a benign schwannoma of World Health Organization grade I.
  • Most of these tumors were benign schwannomas, except for 2 cases of malignant peripheral nerve sheath tumors.
  • The tumor of our patient is the first reported schwannoma of the third ventricle.
  • Histologically, intraventricular schwannoma needs to be distinguished from other spindle cell tumors, in particular pilocytic astrocytoma and fibroblastic meningioma.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Neurilemmoma / pathology. Neurilemmoma / surgery
  • [MeSH-minor] Adult. Brain / pathology. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures

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  • (PMID = 16612987.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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30. Schittenhelm J, Thiericke J, Nagel C, Meyermann R, Beschorner R: WT1 expression in normal and neoplastic cranial and peripheral nerves is independent of grade of malignancy. Cancer Biomark; 2010;7(2):73-7
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  • [Title] WT1 expression in normal and neoplastic cranial and peripheral nerves is independent of grade of malignancy.
  • OBJECTIVE: Wilms' tumor protein (WT1) expression is usually absent in normal glial cells of the CNS but is highly upregulated in brain tumor cells and its expression correlates with tumor grade.
  • However, knowledge on WT1 expression in tumors of the peripheral nerve system (PNS) is limited.
  • As WT1 antibodies not only serve as biomarker for cancerous tissue but also are considered for cancer immunotherapy, knowledge of WT1 expression in tumorous and normal peripheral nerve tissue is important for therapeutical purposes.
  • METHODS: We analyze the immunohistochemical expression of WT1 in 101 samples consisting of 13 normal nerves, 10 neurofibromas, 69 schwannomas and 9 malignant peripheral nerve sheath tumors (MPNST).
  • Tumor samples included 14 specimen from patients with a proven neurocutaneous disorder (neurofibromatosis type 1 and 2) and 3 cases of schwannomatosis.
  • In 50 vestibular schwannomas tumor growth extension was correlated to WT1 expression.
  • In peripheral nerve sheath tumors, cytoplasmic WT1 protein is expressed in the cytoplasm of the neoplastic cells in all tumors, including MPNST, neurofibromas and schwannomas.
  • The WT1 expression is independent of tumor malignancy or tumor growth extension and is not associated with a neurocutaneous disorder.
  • CONCLUSION: WT1 expression in normal and neoplastic tissue differs in the peripheral and the central nervous system.
  • [MeSH-major] Cranial Nerve Neoplasms / metabolism. Cranial Nerves / metabolism. Nerve Sheath Neoplasms / metabolism. Peripheral Nerves / metabolism. WT1 Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Case-Control Studies. Child. Female. Humans. Male. Middle Aged. Neurilemmoma / metabolism. Neurofibroma / metabolism. Young Adult

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  • (PMID = 21178265.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / WT1 Proteins
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31. Chetty R, Vajpeyi R, Penwick JL: Psammomatous melanotic schwannoma presenting as colonic polyps. Virchows Arch; 2007 Sep;451(3):717-20
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  • [Title] Psammomatous melanotic schwannoma presenting as colonic polyps.
  • Psammomatous melanotic schwannoma is an uncommon neoplasm that usually occurs in the setting of Carney's complex.
  • The tumor was diffusely positive for S-100, and focally for HMB-45 and melan-A.
  • The differential diagnosis includes melanoma, GIST, pigmented neuroendocrine tumor, and epithelioid leiomyoma.
  • The lack of malignant features separates this lesion from melanoma while the immunophenotype of the other lesions is characteristic.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Colonoscopy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Immunophenotyping. Leiomyoma, Epithelioid. Melanins / analysis. Melanoma. Neuroendocrine Tumors. Pigmentation

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  • (PMID = 17622556.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Melanins
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32. Ghosh A, Talwar OP, Pradhan SV: Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience. Kathmandu Univ Med J (KUMJ); 2010 Jan-Mar;8(29):97-101
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  • [Title] Tumour and tumour-like conditions of peripheral nerve origin: ten years' experience.
  • BACKGROUND: There are four major lesions which may arise in the peripheral nerve, namely neuroma, schwannoma, neurofibroma and malignant peripheral nerve sheath tumor.
  • OBJECTIVE: In the present study we look into the spectrum of peripheral neural tumors including their age distribution site distribution and histopathology.
  • All histopathologically diagnosed cases of primary lesions of peripheral nerve during the period Jan 2000 to Nov 2009 were reviewed and the data were analysed.
  • RESULT: A total of 114 cases of peripheral neural lesions were reported in the same period.
  • Total number of nonmalignant cases was 106 (93%) while malignant cases were 8 (7%).
  • Among the nonmalignant cases neurofibroma was the commonest (51 cases, 45% of all) closely followed by schwannoma (39 cases, 34% of all).
  • Among the schwannoma cases 4 were diagnosed as ancient schwannoma with presence of bizarre cells with hyperchromatic nuclei.
  • The commonest site involved for both schwannoma and neurofibroma was scalp-face-neck followed by back.
  • The age range for schwannoma was 16 to 75 years whereas the same for the neurofibroma cases was 2 to 82 years.
  • MPNST cases were seen in the age range of 40 to 72 with 3 cases in upper extremity, 3 in lower extremity and 1 each in lip and cheek.
  • CONCLUSION: The majority of the tumor are benign and the commonest benign tumor was neurofibroma of sporadic type, closely followed by schwannoma.
  • [MeSH-major] Nerve Sheath Neoplasms / epidemiology. Neurilemmoma / epidemiology. Neurofibroma / epidemiology. Neuroma / epidemiology. Peripheral Nervous System Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 21209517.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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33. Carlson ML, Babovic-Vuksanovic D, Messiaen L, Scheithauer BW, Neff BA, Link MJ: Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis type 2. J Neurosurg; 2010 Jan;112(1):81-7
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  • Neurofibromatosis Type 2 (NF2) is a rare autosomal dominant disorder characterized by the development of benign tumors of the peripheral nervous system and the CNS, including schwannomas, meningiomas, and ependymomas.
  • The gene responsible for the development of NF2 acts as a tumor suppressor gene.
  • Few reports exist of malignant peripheral nerve sheath tumors, meningiomas, or ependymomas occurring after SRT or stereotactic radiosurgery in patients with NF2.
  • Compared with patients with sporadic tumors, NF2 patients having a germline tumor suppressor gene defect may be more prone to secondary malignancies after treatment involving radiation therapy.
  • [MeSH-minor] Adult. Brain Neoplasms / etiology. Brain Neoplasms / surgery. Brain Stem / pathology. Brain Stem / radiation effects. Brain Stem / surgery. Ear Neoplasms / etiology. Ear Neoplasms / surgery. Fatal Outcome. Female. Humans. Neurilemmoma / etiology. Neurilemmoma / surgery. Vestibular Diseases / etiology. Vestibular Diseases / surgery

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  • [ErratumIn] J Neurosurg. 2010 Jan;112(1):209. Scheithauer, Bernd B [corrected to Scheithauer, Bernd W]
  • (PMID = 19575577.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Prayson RA, Yoder BJ, Barnett GH: Epidermal growth factor receptor is not amplified in schwannomas. Ann Diagn Pathol; 2007 Oct;11(5):326-9
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  • Both neurofibromas and schwannomas are capable of progression to malignant peripheral nerve sheath tumors (MPNSTs).
  • The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR; however, acquiring this signaling pathway might contribute to the progression of a subset of benign peripheral nerve sheath tumors to MPNST.
  • [MeSH-major] Nerve Sheath Neoplasms / metabolism. Neurilemmoma / metabolism. Receptor, Epidermal Growth Factor / metabolism
  • [MeSH-minor] Adult. Aged. DNA, Neoplasm / genetics. Disease Progression. Female. Gene Amplification. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 17870017.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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35. Yang BB, Jiang H, Chang HY: Malignant triton tumour of the parapharyngeal space: a case arising from the cervical sympathetic nerve. J Laryngol Otol; 2008 May;122(5):531-4
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  • [Title] Malignant triton tumour of the parapharyngeal space: a case arising from the cervical sympathetic nerve.
  • BACKGROUND: Malignant triton tumour is a relatively rare, aggressive sarcoma comprising both malignant schwannoma cells and malignant rhabdomyoblasts.
  • Malignant triton tumour of the parapharyngeal space is exceptionally rare, with only one case being described in the literature.
  • Malignant triton tumour of the cervical sympathetic nerve has not previously been reported.
  • METHODS: We report a case involving the parapharyngeal space and arising from the cervical sympathetic nerve, and we review the management and outcome of the previous case reported in this rare location.
  • Owing to this specific localisation, adjuvant therapy in addition to complete resection may be important in the treatment of malignant triton tumour in this rare location.
  • [MeSH-major] Neurilemmoma / pathology. Pharyngeal Neoplasms / pathology. Sarcoma / pathology. Sympathetic Nervous System / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17498335.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Bendix N, Wolf C, Gruber H, Bodner G: [Pictorial essay: Ultrasound of tumours and tumour-like lesions of peripheral nerves]. Ultraschall Med; 2005 Aug;26(4):318-24
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  • [Title] [Pictorial essay: Ultrasound of tumours and tumour-like lesions of peripheral nerves].
  • High-resolution ultrasound is an excellent diagnostic modality for visualising peripheral nerves and differentiate tumours of the peripheral nerve.
  • With high-frequency transducers (5-15 MHz), peripheral nerves can be visualised, the hypoechoic nerve fascicles, the surrounding tissue and tumourous lesions including the relation to their nerve of origin can be evaluated.
  • By using colour Doppler sonography (CDS), it is possible to detect and assess vascularisation of tumours of the nerve.
  • We present sonographic features of common and uncommon benign and malignant tumours of the peripheral nerve.
  • [MeSH-major] Peripheral Nerve Injuries. Peripheral Nervous System Diseases / ultrasonography. Peripheral Nervous System Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neurilemmoma / ultrasonography. Neurofibroma / ultrasonography. Neuroma / ultrasonography. Peripheral Nerves / ultrasonography. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 16123927.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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37. Theodosopoulos T, Stafyla VK, Tsiantoula P, Yiallourou A, Marinis A, Kondi-Pafitis A, Chatziioannou A, Boviatsis E, Voros D: Special problems encountering surgical management of large retroperitoneal schwannomas. World J Surg Oncol; 2008;6:107
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  • BACKGROUND: Retroperitoneal schwannomas are rare, usually benign tumors that originate in the neural sheath and account for only a small percentage of retroperitoneal tumors.
  • The aim of this clinical study is to present our experience in managing retroperitoneal schwannomas with a review of the current literature and to point out the surgical technical difficulties we faced, due to the tumor's strange behavior that eroded the vertebra in two cases without causing malignant invasion.
  • One patient, after having a non-diagnostic computed tomography fine needle aspiration (CT-FNA), underwent exploratory laparotomy and incisional biopsy that established the diagnosis of schwannoma.
  • [MeSH-major] Neurilemmoma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 18834531.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 34
  • [Other-IDs] NLM/ PMC2567322
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38. Dong Z, Yang Z, Li Y, Min P, Zhang X: [Extra-organic primary tumor in pelvis: correlation of multi-detector row computed tomography, anatomy and pathology]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2009 Feb;26(1):75-9
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  • [Title] [Extra-organic primary tumor in pelvis: correlation of multi-detector row computed tomography, anatomy and pathology].
  • Calcification occurred in 6 cases, including 4 cases of teratoma, 1 case of neurilemmoma, and 1 case of malignant teratoma.
  • The fatty element occurred in 7 masses, including 4 cases of teratoma, 1 case of malignant teratoma, 1 case of mixed germ cell tumor, and 1 case of liposarcoma.
  • MDCT with multi-planar reconstruction (MPR) could more clearly reveal the anatomic location of the extra-organic primary tumor in pelvis, could unveil the tumor's relationship with its surrounding organs, and could help to differentiate benign tumors from malignant tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Imaging, Three-Dimensional. Infant. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 19334559.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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39. Marton E, Feletti A, Orvieto E, Longatti P: Dumbbell-shaped C-2 psammomatous melanotic malignant schwannoma. Case report and review of the literature. J Neurosurg Spine; 2007 Jun;6(6):591-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dumbbell-shaped C-2 psammomatous melanotic malignant schwannoma. Case report and review of the literature.
  • The authors present the case of a dumbbell-shaped malignant psammomatous melanotic schwannoma of the upper cervical spine involving the C-2 sensory root.
  • The family of the patient had a history of other malignant stromal tumors, without the Carney complex genetic pattern.
  • Histopathological examination of the lesion revealed it to be a malignant psammomatous melanotic schwannoma.
  • The cerebrospinal MR image of the patient obtained at the 12-month follow-up examination demonstrated the presence of tumor progression into the subarachnoid space at the C-3 level.
  • The strong malignancy potential of the lesion must be considered in the future management of the patient, especially due to the presence in the family of other stromal tumors such as gastrointestinal-stromal tumors and malignant melanomas.
  • The authors review all the literature concerning melanotic schwannomas and report 105 cases of melanotic schwannoma that were not related to the Carney complex.
  • The particular focus of their review is on the characteristics of the malignant progression of melanotic schwannoma, such as local recurrences, metastasis, and survival rate.
  • [MeSH-major] Cervical Vertebrae. Neurilemmoma / diagnosis. Spinal Neoplasms / diagnosis. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neurosurgical Procedures

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  • (PMID = 17561752.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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40. Tahir MZ, Fatimi SH, Enam SA: Ancient schwannoma presenting as a thoracic mass. Surg Neurol; 2007 Nov;68(5):534-6
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  • [Title] Ancient schwannoma presenting as a thoracic mass.
  • BACKGROUND: Ancient schwannoma is a rare variant of schwannoma, histologically showing atypical features that may result in erroneous diagnosis of a malignant tumor.
  • CASE DESCRIPTION: We report a case of a 34-year-old man who was found to have giant mediastinal tumor.
  • He underwent thoracotomy to remove the mass, which was proven to be ancient schwannoma on histopathology.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17765953.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Karube K, Nabeshima K, Ishiguro M, Harada M, Iwasaki H: cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours. J Clin Pathol; 2006 Feb;59(2):160-5
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  • [Title] cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours.
  • BACKGROUND: Malignant peripheral nerve sheath tumour (MPNST) is a highly aggressive malignancy that arises within peripheral nerves, and is associated with poor prognosis.
  • Little is known about the underlying biology of MPNST, especially the mechanisms involved in cell proliferation, invasion, or escape from apoptosis.
  • AIMS: To identify genes differentially expressed in MPNST compared with benign tumours, such as neurofibromas and schwannomas, by means of cDNA microarray analysis.
  • METHODS: Six MPNST cases and five benign cases (three schwannomas and two neurofibromas) were analysed.
  • RESULTS: Six genes (keratin 18, survivin, tenascin C, adenosine deaminase, collagen type VIa3, and collagen type VIIa1) were significantly upregulated in MPNST, whereas one gene, insulin-like growth factor binding protein 6, was downregulated in MPNST.
  • Immunohistochemistry confirmed upregulation of survivin in MPNST at the protein level in six of eight cases compared with benign tumours.
  • Tenascin C was also expressed at the invasive front and tumorous stroma in all MPNST cases.
  • MPNST cells expressed tenascin C in four of nine cases.
  • CONCLUSIONS: Survivin and tenascin C may be associated with the malignant potential of MPNST and could be considered as potential therapeutic targets.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Neoplasm Proteins / biosynthesis. Nerve Sheath Neoplasms / metabolism. Peripheral Nervous System Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Gene Expression Profiling / methods. Humans. Immunoenzyme Techniques. Inhibitor of Apoptosis Proteins. Male. Microtubule-Associated Proteins / biosynthesis. Microtubule-Associated Proteins / genetics. Middle Aged. Neurilemmoma / genetics. Neurilemmoma / metabolism. Neurilemmoma / pathology. Neurofibroma / genetics. Neurofibroma / metabolism. Neurofibroma / pathology. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction / methods. Tenascin / biosynthesis. Tenascin / genetics. Up-Regulation

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  • (PMID = 16443732.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Tenascin
  • [Other-IDs] NLM/ PMC1860323
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42. Oxner CR, Shinners MJ, Godin DA, Lyn IT, Brent RB, McFadden PM: Obstructing tracheobronchial schwannoma. J La State Med Soc; 2005 May-Jun;157(3):159-61
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  • [Title] Obstructing tracheobronchial schwannoma.
  • Endotracheal and endobronchial schwannomas are extremely rare tumors of neurogenic origin.
  • Two cases of tracheobronchial schwannoma with proximal airway obstruction are reported.
  • Because malignant transformation is exceedingly rare, operative resection of tracheobronchial schwannomas based on the principle of conservation of lung parenchyma is emphasized.
  • [MeSH-major] Airway Obstruction / etiology. Neurilemmoma / diagnosis. Tracheal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Bronchoscopy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16173316.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Li Q, Gao C, Juzi JT, Hao X: Analysis of 82 cases of retroperitoneal schwannoma. ANZ J Surg; 2007 Apr;77(4):237-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of 82 cases of retroperitoneal schwannoma.
  • BACKGROUND: The aim of the study was to improve the diagnosis and treatment of retroperitoneal schwannoma by analysing clinical manifestations and postoperative course of this rare disease.
  • METHODS: A retrospective analysis of 82 patients with retroperitoneal schwannoma between January 1951 and September 2004 was carried out.
  • Pathological results showed 81 (98.8%) were benign schwannoma and 1 (1.2%) was a malignant one.
  • One benign schwannoma recurred 3 years after the operation.
  • The patient with malignant schwannoma died 18 months after the operation because of metastasized disease.
  • Malignant schwannomas are insensitive to chemotherapy and radiation, resulting in poor prognosis.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / surgery. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnostic Imaging. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17388825.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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44. Levi AD, Ross AL, Cuartas E, Qadir R, Temple HT: The surgical management of symptomatic peripheral nerve sheath tumors. Neurosurgery; 2010 Apr;66(4):833-40
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  • [Title] The surgical management of symptomatic peripheral nerve sheath tumors.
  • OBJECTIVE: To determine the clinical presentation and morbidity of the surgical management of peripheral nerve sheath tumors (PNSTs).
  • RESULTS: There were a total of 140 cases, including 87 schwannomas, 34 neurofibromas, and 19 malignant peripheral nerve sheath tumors (MPNSTs).
  • Tumor size was the best predictor of adverse outcome, as all MPNST mortalities occurred in patients with a tumor size of more than 7 cm.
  • [MeSH-major] Nerve Sheath Neoplasms / surgery. Neurilemmoma / surgery. Neurofibroma / surgery. Neurosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20190660.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Domanski HA, Akerman M, Engellau J, Gustafson P, Mertens F, Rydholm A: Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients. Diagn Cytopathol; 2006 Jun;34(6):403-12
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  • [Title] Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients.
  • There were 6 false-positive malignant diagnoses while 23 smears were considered insufficient and 7 inconclusive as to whether benign or malignant.
  • Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors.
  • [MeSH-major] Biopsy, Fine-Needle. Neurilemmoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. False Positive Reactions. Female. Humans. Male. Middle Aged. S100 Proteins / metabolism. Sarcoma / pathology. Sensitivity and Specificity

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  • (PMID = 16680779.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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46. Subhashraj K, Balanand S, Pajaniammalle S: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal; 2009 Jan;14(1):E12-4
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  • [Title] Ancient schwannoma arising from mental nerve. A case report and review.
  • Schwannoma is an intraoral rare, benign neoplasm derived from the nerve sheath of peripheral nerves.
  • "Ancient schwannoma" shows histopathological features, such as degenerative changes and atypical nuclei, and may easily be confused with malignant neoplasms.
  • Ancient schwannoma of the head and neck region is relatively uncommon and very few cases had been reported in the oral cavity.
  • We present a case of ancient schwannoma arising from the mental nerve in a 19 year old male which was of eight months duration.
  • Ultrasonography showed that the tumor was closely associated with the mental nerve on the left side, suggestive of a peripheral neural sheath tumor.
  • Complete excision of the lesion was done under local anesthesia, preserving the mental nerve.
  • The histological picture was strongly suggestive of ancient schwannoma (Antoni A type).
  • [MeSH-major] Chin / innervation. Neurilemmoma / pathology. Peripheral Nervous System Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Young Adult

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  • (PMID = 19114949.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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47. Ducic Y, Oxford L, Pontius AT: Transoral approach to the superomedial parapharyngeal space. Otolaryngol Head Neck Surg; 2006 Mar;134(3):466-70
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  • METHODS: Eight patients with various neoplasms of the superomedial PPS were retrospectively reviewed for type of neoplasm, size, success with the transoral approach, need for conversion to another approach, length of hospitalization, and complications.
  • The most common pathology encountered was that of schwannoma.
  • Mean tumor size was 3.3 cm (range, 1.5 to 7 cm).
  • This approach alone may not provide adequate access for resection of malignant lesions especially those with extension intracranially or to more inferior or laterally placed lesions of the parapharyngeal space.
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carotid Artery, Internal / pathology. Child. Female. Follow-Up Studies. Humans. Intraoperative Care. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Neurilemmoma / pathology. Neurilemmoma / surgery. Postoperative Complications. Retrospective Studies. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 16500446.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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48. Fukushima S, Kageshita T, Wakasugi S, Matsushita S, Kaguchi A, Ishihara T, Ono T: Giant malignant peripheral nerve sheath tumor of the scalp. J Dermatol; 2006 Dec;33(12):865-8
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  • [Title] Giant malignant peripheral nerve sheath tumor of the scalp.
  • Herein, we describe a rare case of giant malignant peripheral nerve sheath tumor of the head in a 38-year-old Japanese man.
  • The tumor measured 210 mm at its largest diameter and was ulcerated, hemorrhagic, multilocular and non-mobile.
  • It should be noted that the patient stubbornly refused to see a doctor for a long time, resulting in the extreme growth of the tumor.
  • Dermatohistopathological findings of the biopsy indicated ancient schwannoma and total excision was therefore performed.
  • Post-mortem skin biopsy revealed features of malignant peripheral nerve sheath tumor.
  • We propose that the expressions of Ki67 and p16 should be checked for all lesions of peripheral nerve sheath tumor for distinguishing benign from malignant forms.
  • [MeSH-major] Neurilemmoma / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Fatal Outcome. Hemorrhage / pathology. Humans. Ki-67 Antigen / analysis. Male. Skin Ulcer / pathology

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  • (PMID = 17169091.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen
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49. Zadeh G, Buckle C, Shannon P, Massicotte EM, Wong S, Guha A: Radiation induced peripheral nerve tumors: case series and review of the literature. J Neurooncol; 2007 Jun;83(2):205-12
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  • [Title] Radiation induced peripheral nerve tumors: case series and review of the literature.
  • PURPOSE: Radiation induced peripheral nerve tumors (PNT) are a rare but known complication of radiotherapy.
  • RESULTS: Patient's ranged in age from 18 months to 49 years at the time of their original diagnosis, with radiation doses to the primary tumor ranging from 24 to 40 Gy with post radiation intervals from 10 to 50 years.
  • While the pathology of PNT induced transformation is still poorly understood, experiments and pathology are congruent on the possibility of malignant transformation, especially for the "atypical neurofibroma".
  • [MeSH-major] Neoplasms, Radiation-Induced / etiology. Neurilemmoma / etiology. Neurofibroma / etiology. Peripheral Nervous System Neoplasms / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasms / radiotherapy. Peripheral Nerves / radiation effects. Radiotherapy / adverse effects

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  • (PMID = 17206473.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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50. Siqueira MG, Martins RS, Teixeira MJ: Management of brachial plexus region tumours and tumour-like conditions: relevant diagnostic and surgical features in a consecutive series of eighteen patients. Acta Neurochir (Wien); 2009 Sep;151(9):1089-98
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  • FINDINGS: The tumours comprised a heterogeneous group of lesions, including schwannomas, neurofibromas, malignant peripheral nerve sheath tumour (MPNST), sarcomas, metastases, desmoids and an aneurysmal bone cyst.
  • Eleven tumours were benign and 7 were malignant.
  • Some of the malignant tumours could be controlled by surgery plus adjuvant therapy, but this category is still associated with high morbidity and mortality rates.
  • [MeSH-major] Brachial Plexus / pathology. Brachial Plexus / surgery. Brachial Plexus Neuropathies / diagnosis. Brachial Plexus Neuropathies / surgery. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Bone Cysts, Aneurysmal / diagnosis. Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / surgery. Child. Female. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / physiopathology. Fibromatosis, Aggressive / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / physiopathology. Neoplasm Recurrence, Local / epidemiology. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / physiopathology. Nerve Sheath Neoplasms / surgery. Neurilemmoma / diagnosis. Neurilemmoma / physiopathology. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / physiopathology. Neurofibroma / surgery. Neurosurgical Procedures. Pain / etiology. Paresthesia / etiology. Postoperative Complications / epidemiology. Retrospective Studies. Sarcoma / diagnosis. Sarcoma / physiopathology. Sarcoma / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19448970.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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51. Cheng JW, Tang SF, Yu TY, Chou SW, Wong AM, Tsai WC: Sonographic features of soft tissue tumors in the hand and forearm. Chang Gung Med J; 2007 Nov-Dec;30(6):547-54
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  • The mobility, consistency, echogenicity, margin, and color Doppler signal of each tumor were assessed.
  • RESULTS: The pathologic diagnoses of these soft tissue lesions were lipoma (n = 6), ganglion cyst (n = 6), neurilemmoma (n = 3), neurofibroma (n = 3), giant cell tumor (n = 10), tenosynovitis (n = 2), and malignant lymphoma (n = 1).
  • An adjacent tendon or communication duct extending to the joint space could be found in most giant cell tumors and ganglion cysts; a traceable nerve could be found in most nerve sheath tumors.
  • The only malignant tumor appeared ill-defined without a color Doppler signal.
  • [MeSH-minor] Adult. Aged. Female. Ganglion Cysts / ultrasonography. Giant Cell Tumors / ultrasonography. Humans. Lipoma / ultrasonography. Male. Middle Aged. Nerve Sheath Neoplasms / ultrasonography. Retrospective Studies. Tenosynovitis / ultrasonography

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  • (PMID = 18350738.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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52. Fernández-Aceñero MJ, Larach F, Ortega-Fernández C: Non-epithelial lesions of the larynx: review of the 10-year experience in a tertiary Spanish hospital. Acta Otolaryngol; 2009 Jan;129(1):108-12
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  • We had two cases of chondrosarcoma, one case of liposarcoma, one case of synovial sarcoma, and one neural benign tumor, suggestive of neurinoma.
  • In this period we also had an inflammatory pseudotumor affecting the vocal cord, a case of primary laryngeal extramedullary plasmocytoma, and one case of high grade diffuse malignant lymphoma with exclusive involvement of the larynx.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Chondrosarcoma / pathology. Chondrosarcoma / radiotherapy. Chondrosarcoma / surgery. Female. Granuloma, Plasma Cell / pathology. Granuloma, Plasma Cell / radiotherapy. Granuloma, Plasma Cell / surgery. Humans. Liposarcoma / pathology. Liposarcoma / radiotherapy. Liposarcoma / surgery. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / radiotherapy. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Neurilemmoma / pathology. Neurilemmoma / radiotherapy. Neurilemmoma / surgery. Plasmacytoma / pathology. Plasmacytoma / radiotherapy. Plasmacytoma / surgery. Retrospective Studies. Sarcoma, Synovial / pathology. Sarcoma, Synovial / radiotherapy. Sarcoma, Synovial / surgery. Spain. Vocal Cords / pathology. Vocal Cords / surgery. Young Adult

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  • (PMID = 18607979.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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53. Suriano M, de Vincentiis M, Mascelli A, Calabrese V, Gallo A: Parapharyngeal high-grade malignant schwannoma with extension to infratemporal and pterygopalatine fossa. Otolaryngol Head Neck Surg; 2007 Nov;137(5):839-40
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  • [Title] Parapharyngeal high-grade malignant schwannoma with extension to infratemporal and pterygopalatine fossa.
  • [MeSH-major] Neurilemmoma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Cranial Fossa, Middle. Humans. Male. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local. Neurofibromatosis 1 / complications. Skull Base Neoplasms / pathology

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  • (PMID = 17967659.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Castelli J, Thariat J, Benezery K, Courdi A, Chanalet S, Paquis P, Doyen J, Frenay M, Mammar H, Bondiau PY: [Spinals and paraspinals tumors treated by CyberKnife: feasibility and efficacy]. Cancer Radiother; 2010 Jan;14(1):5-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Stereotactic radiotherapy using the CyberKnife has become a key treatment in the multidisciplinary management of secondary tumours, as well as primary benign or malignant tumours located within or adjacent to vertebral bodies and the spinal cord.
  • [MeSH-minor] Adult. Aged. Chordoma / mortality. Chordoma / surgery. Disease-Free Survival. Feasibility Studies. Female. Hemangioma / mortality. Hemangioma / surgery. Humans. Male. Meningeal Neoplasms / mortality. Meningeal Neoplasms / surgery. Meningioma / mortality. Meningioma / surgery. Middle Aged. Neoplasm Metastasis. Neurilemmoma / mortality. Neurilemmoma / surgery. Osteosarcoma / mortality. Osteosarcoma / surgery. Radiation Dosage. Radiometry

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  • [Copyright] 2009 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20005764.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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55. Qu H, Wang CF, Zhao P, Shan Y, Zhao DB: [Local resection of pancreatic neoplasms: clinical analysis of 17 cases]. Zhonghua Yi Xue Za Zhi; 2008 May 27;88(20):1405-7
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  • Pathological examination confirmed 8 tumors as nonfunctioning insulinoma, 5 as solid pseudopapillary tumor, 1 as neurilemmoma, 1 as cyst, 1 as gastrointestinal stroma tumor, and 1 as low-graded malignant tumor.
  • CONCLUSION: Capable pf preserving endocrine and exocrine functions, local resection is a feasible method for benign or low-graded malignant pancreatic neoplasms, however, with a high rate of pancreatic leakage.
  • [MeSH-minor] Adult. Aged. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 18953880.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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56. Zhang HY, Yang GH, Chen HJ, Wei B, Ke Q, Guo H, Ye L, Bu H, Yang K, Zhang YH: Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J (Engl); 2005 Sep 5;118(17):1451-61
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  • [Title] Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma.
  • BACKGROUND: Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • We investigated the clinicopathologic features, immunophenotypes, and ultrastructural features of 13 patients with nonpsammomatous melanotic schwannoma (NPMS).
  • METHODS: Tumor specimens of each patient were sectioned and stained with hematoxylin-eosin, Fontana-Masson, Prussian blue, and periodic acid-Schiff (PAS).
  • The tumor sites included the spinal nerve root (5 patients), cranial nerve (1), greater omentum (1), subcutaneous tissue (3), mesentery (1), bone (1) and mediastinum (1).
  • One patient (9.1%) with a primary tumor in the greater omentum developed another primary tumor of the same type in the subcutaneous tissue of the abdominal wall after the first operation.
  • Local recurrence of the tumor was seen in 2 patients (18.2%).
  • The tumor was composed of spindled and epithelioid cells with abundant intracytoplasmic melanin pigments.
  • Ultrastructurally, numerous elongated tumor-cell processes, duplicated basement membrane and melanosomes were observed in all developmental stages.
  • CONCLUSIONS: Histologically, melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • Distinguishing between this tumor and malignant melanoma is of paramount importance in planning of management.
  • Immunohistochemically, combined use of laminin and collagen IV is valuable in distinguishing melanotic schwannoma from malignant melanoma.
  • Further studies including cytogenetic or molecular biology are still required to better delineate melanotic schwannoma from malignant melanoma.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Prognosis


57. Zhang R, Zhou LF, Mao Y: [Microsurgical treatment of nonmeningeal tumors of the cavernous sinus]. Zhonghua Yi Xue Za Zhi; 2005 Jun 1;85(20):1373-8
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  • RESULTS: The main clinical presentation included cranial nerve paralysis (47 cases, 70.1%), neuroendocrine symptoms (11 cases, 16.4%), eye pain (9 cases, 13.6%), proptosis (7 cases, 10.6%), limb weakness (5 cases, 7.5%), headache, dizziness, lethargy, and temporal lobe epilepsy (4 cases each), and epistaxis (1 case).
  • Pathological examination revealed that hemangioma (24 cases), trigeminal schwannoma (18 cases), and invasive pituitary adenomas (11 cases) comprised the majority of tumors; the remaining tumor types were chordoma, chondroma, chondromyosarcoma, chondrofibroma, dermoid tumor, malignant nerve sheath tumor, metastatic tumor, and lymphoma.
  • In the intradural approach group, total tumor removal was achieved in 8 cases (40%), and 7 (35%) cases and 5 (25%) cases had subtotal and partial resection respectively.
  • In the epidural approach group, 27 cases (81.8%) had total tumor removal, while 1 case (3.0%) had subtotal and 5 cases had partial excision of the tumor.
  • The aggressive or new symptoms mainly included paralysis of oculomotor nerve (13 cases, 19.4%), trigeminal nerve (9 cases, 13.4%), and abduct nerve (9 cases, 13.4%).
  • CONCLUSION: Depending on pathologic type and growth pattern of the tumor, extended middle skull base epidural or epidural-transdural approach is selected.
  • Such techniques can offer satisfactory outcome, protecting the cranial nerve functions and removing the tumor to the maximum extent.
  • [MeSH-major] Central Nervous System Neoplasms / surgery. Cranial Nerve Neoplasms / surgery. Hemangioma, Cavernous, Central Nervous System / surgery. Microsurgery. Trigeminal Nerve Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cavernous Sinus / surgery. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neurilemmoma / diagnosis. Neurilemmoma / surgery. Retrospective Studies

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  • (PMID = 16029646.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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58. Sestan B, Miletic D, Jonjic N, Gulan G: Intraosseous epithelioid malignant schwannoma. Orthopedics; 2007 Jan;30(1):67-9
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  • [Title] Intraosseous epithelioid malignant schwannoma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Neurilemmoma / diagnosis. Tibia
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 17260666.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Lustgarten L, Abadi JR, Sancevic R, Meneses P, Perez Morrel A, Lugo J: Use of a protein-based tissue adhesive as an aid for the surgical reconstruction of advanced and recurrent skin cancer tumors to the head and neck region: a technical report. Surg Neurol; 2007 Jul;68(1):53-9; discussion 59
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  • Pathology included squamous (7) and basal (3) cell carcinoma and malignant schwannoma (1).
  • Three patients required additional brain resection because of tumor infiltration.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brain / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Craniotomy. Dura Mater / surgery. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neurilemmoma / surgery. Nose / surgery. Orbit / surgery. Postoperative Complications / mortality

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  • (PMID = 17586223.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bio-glue; 0 / Proteins; 0 / Tissue Adhesives
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60. Tagore KR, Krishna R, Charyulu PA, Latha PP: A rare case of cellular schwannoma in the pharynx. Indian J Pathol Microbiol; 2007 Oct;50(4):835-7
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  • [Title] A rare case of cellular schwannoma in the pharynx.
  • These tumors histologically mimic malignant peripheral nerve sheath tumors because of their growth pattern, high cellularity and mitotic activity, but they are relatively benign tumors with a tendency to recur but do not metastasize.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / pathology. Pharyngeal Neoplasms / diagnosis. Pharyngeal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neck / radiography. Tomography, X-Ray Computed

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  • (PMID = 18306575.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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61. Li CS, Huang GS, Wu HD, Chen WT, Shih LS, Lii JM, Duh SJ, Chen RC, Tu HY, Chan WP: Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging. Clin Imaging; 2008 Mar-Apr;32(2):121-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging.
  • PURPOSE: The objective of this study was to differentiate the magnetic resonance (MR) imaging appearance of benign peripheral nerve sheath tumors (PNSTs) from that of malignant PNSTs.
  • MATERIALS AND METHODS: Twenty-six patients who underwent MR imaging and had a histologic diagnosis of benign (schwannoma, n=16; neurofibroma, n=1) or malignant (n=9) PNST were retrospectively reviewed.
  • =2.5 cm) was significantly smaller than that of the malignant tumors (8.2 cm, S.D.
  • Seventeen (65.4%) of the 26 tumors were spindle shaped or ovoid (12 benign and 5 malignant tumors).
  • Contiguity with specific nerves was identified in 15 (88.2%) of the 17 benign PNSTs but in none of the malignant tumors (P<.05).
  • Well-defined margins were noted in all 17 benign PNSTs but in only 3 (33.3%) of the 9 malignant tumors (P<.001).
  • Five (55.6%) of the 9 malignant PNSTs but none of the benign tumors showed signal intensity change in adjacent soft tissue (P<.05).
  • There was no significant difference in signal intensity between the benign and malignant tumors on T(1)-weighted, T(2)-weighted, and contrast-enhanced MR images.
  • The split fat and target signs were present more frequently in the benign PNSTs than in the malignant PNSTs (P<.05).
  • CONCLUSIONS: Benign and malignant PNSTs are often spindle shaped.
  • [MeSH-major] Magnetic Resonance Imaging. Peripheral Nervous System Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Gadolinium DTPA. Humans. Male. Middle Aged. Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / diagnosis. Neurofibroma / diagnosis

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  • (PMID = 18313576.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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62. Freitas VA, Saliba MC, Moraes EC, Teixeira GA, Oliveira JB: Malignant Schwannoma in patients with von Recklinghausen disease: report of two cases. Braz J Otorhinolaryngol; 2009 Jan-Feb;75(1):160
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  • [Title] Malignant Schwannoma in patients with von Recklinghausen disease: report of two cases.
  • [MeSH-major] Head and Neck Neoplasms / etiology. Neurilemmoma / etiology. Neurofibromatosis 1 / complications. Sarcoma / etiology
  • [MeSH-minor] Adult. Humans. Male


63. De Waele M, Carp L, Lauwers P, Hendriks J, De Maeseneer M, Van Schil P, Blockx P: Paravertebral schwannoma with high uptake of fluorodeoxyglucose on positron emission tomography. Acta Chir Belg; 2005 Sep-Oct;105(5):537-8
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  • [Title] Paravertebral schwannoma with high uptake of fluorodeoxyglucose on positron emission tomography.
  • CT, MRI and fine needle aspiration cytology (FNAC) pointed in the direction of a benign mass, but positron emission tomography (PET) showed a high uptake of [(18)F]fluorodeoxyglucose (FDG), which was indicative of a malignant lesion.
  • Pathological analysis of the thoracoscopically resected tumour gave us the final diagnosis of a benign schwannoma.
  • This report demonstrates that a high uptake of FDG in a non-malignant mediastinal tumour is possible.
  • [MeSH-major] Neurilemmoma / radionuclide imaging. Spinal Neoplasms / radionuclide imaging
  • [MeSH-minor] Adult. Female. Fluorodeoxyglucose F18. Humans. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 16315843.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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64. Luna-Ortiz K, Navarrete-Alemán JE, Granados-García M, Herrera-Gómez A: Primary parapharyngeal space tumors in a Mexican cancer center. Otolaryngol Head Neck Surg; 2005 Apr;132(4):587-91
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  • Sixteen (76%) patients had benign lesions and 5 (24%) had malignant tumors.
  • Neurogenic tumors represented 57% of all tumors.
  • Mean tumor size was of 6.7 cm (range, 3 to 11 cm).
  • Complications occurred in 6 (29%) patients, 4 (19%) of which were nervous injuries associated with peripheral nerve sheath tumors.
  • Conversion to mandibular swing approach when the cervical approach is not offering proper exposure for tumor resection is indicated.
  • Nevertheless, CT scan should always be performed in order to exclude paragangliomas, distinguish prestyloid from poststyloid lesions, and to assess the extension of the tumor as well as its relationship with adjacent structures.
  • [MeSH-major] Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / diagnosis. Pharyngeal Neoplasms / diagnosis
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / mortality. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / radiotherapy. Adenoma, Pleomorphic / surgery. Adult. Aged. Biopsy, Fine-Needle. Cancer Care Facilities. Cervical Vertebrae / surgery. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Mexico. Middle Aged. Parotid Gland / pathology. Parotid Gland / surgery. Pharyngectomy / methods. Pharynx / pathology. Postoperative Complications / etiology. Postoperative Complications / mortality. Radiotherapy, Adjuvant. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 15806051.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Azarpira N, Torabineghad S, Sepidbakht S, Rakei M, Bagheri MH: Cytologic findings in pigmented melanotic schwannoma: a case report. Acta Cytol; 2009 Jan-Feb;53(1):113-5
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  • [Title] Cytologic findings in pigmented melanotic schwannoma: a case report.
  • BACKGROUND: Psammomatous melanotic schwannoma (PMS) is a rare pigmented neural tumor most commonly occurring in the paraspinal region.
  • This rare tumor can cause diagnostic difficulties in imprint cytology due to cellular details masked by heavy melanin pigments.
  • Radiologic studies showed a 3.5-cm epidural mass in the region of the left L2 nerve root.
  • Imprint smears from the biopsied tissue fragment revealed mainly epithelioid cells with prominent nucleoli and variable amounts of cytoplasmic brown pigment, indicating a pigmented tumor with neuronal origin PMS, which was confirmed by histologic and immunohistochemical studies of the resected tumor.
  • CONCLUSION: PMS is a rare entity, and it is important to differentiate PMS from other pigmented tumors in the spinal canal, such as melanocytoma and malignant melanoma.
  • [MeSH-major] Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Melanins. Pigmentation

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  • (PMID = 19248566.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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66. Shimada S, Tsuzuki T, Kuroda M, Nagasaka T, Hara K, Takahashi E, Hayakawa S, Ono K, Maeda N, Mori N, Illei PB: Nestin expression as a new marker in malignant peripheral nerve sheath tumors. Pathol Int; 2007 Feb;57(2):60-7
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  • [Title] Nestin expression as a new marker in malignant peripheral nerve sheath tumors.
  • Malignant peripheral nerve sheath tumor (MPNST) can be difficult to diagnose because it lacks specific immunohistochemical markers.
  • S-100, which is a useful marker of MPNST, has limited diagnostic utility.
  • The diagnostic utility of immunostains for nestin and three other neural markers (S-100, CD56 and protein gene product 9.5 (PGP 9.5)) were evaluated in 35 cases of MPNST and in other spindle cell tumors.
  • All MPNST cases were strongly positive for nestin and had cytoplasmic staining.
  • Nestin was negative in 10/10 leiomyomas, and weak nestin expression was seen in 10/10 schwannomas, 3/10 neurofibromas, 2/8 synovial sarcomas, 2/10 liposarcomas, 4/7 carcinosarcomas and 3/7 malignant fibrous histiocytomas.
  • Nestin is more sensitive for MPNST than other neural markers and immunostains for nestin in combination with other markers could be useful in the diagnosis of MPNST.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Intermediate Filament Proteins / metabolism. Nerve Sheath Neoplasms / metabolism. Nerve Tissue Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Cauda Equina / metabolism. Cauda Equina / pathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. Child. Female. Gene Expression Regulation, Neoplastic. Humans. Leiomyosarcoma / metabolism. Leiomyosarcoma / pathology. Male. Melanoma / metabolism. Melanoma / pathology. Middle Aged. Nestin. Neurilemmoma / metabolism. Neurilemmoma / pathology. Rhabdomyosarcoma / metabolism. Rhabdomyosarcoma / pathology. Sarcoma / metabolism. Sarcoma / pathology. Schwann Cells / metabolism. Schwann Cells / pathology

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  • (PMID = 17300669.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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67. Misra MC, Bhattacharjee HK, Hemal AK, Bansal VK: Laparoscopic management of rare retroperitoneal tumors. Surg Laparosc Endosc Percutan Tech; 2010 Jun;20(3):e117-22
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  • Due to their close proximity to major vessels, large size, variable location, and unknown malignant status, retroperitoneal tumors are frequently managed by open surgical exploration.
  • The histology reported retroperitoneal ganglioneuroma, retroperitoneal schwannoma, and retroperitoneal paraganglioma.
  • There has been no tumor recurrence at a mean follow-up of 39 months.
  • [MeSH-major] Ganglioneuroma / surgery. Laparoscopy. Neurilemmoma / surgery. Paraganglioma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged

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  • (PMID = 20551790.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Kim MS, Park K, Kim JH, Kim YD, Lee JI: Gamma knife radiosurgery for orbital tumors. Clin Neurol Neurosurg; 2008 Dec;110(10):1003-7
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  • Seven patients with preserved vision and tumors located near the optic nerve were treated with multisession (3 or 4 fractions) radiosurgery.
  • The mean tumor volume was 3695mm3 (737-13,300).
  • RESULTS: After a mean follow-up of 20.9 months (6-50), tumor control was confirmed in 12 of 15 patients.
  • Three patients with malignant lesions had to undergo another operation due to tumor progression.
  • Of the 13 patients whose preoperative vision was preserved, 6 patients showed improvement in visual acuity and/or visual field, 4 patients showed no change in vision, and 3 patients showed deterioration (2 related to tumor progression).
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / physiopathology. Hemangioma, Cavernous / surgery. Humans. Magnetic Resonance Imaging. Male. Meningioma / pathology. Meningioma / physiopathology. Meningioma / surgery. Middle Aged. Neurilemmoma / pathology. Neurilemmoma / physiopathology. Neurilemmoma / surgery. Optic Nerve Injuries / etiology. Optic Nerve Injuries / physiopathology. Optic Nerve Injuries / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / surgery. Reoperation / methods. Retrospective Studies. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology. Vision, Low / surgery. Visual Fields / physiology. Young Adult

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  • (PMID = 18653273.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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69. Dartnell J, Pilling J, Ferner R, Cane P, Lang-Lazdunski L: Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. J Thorac Oncol; 2009 Jan;4(1):135-7
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  • [Title] Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor.
  • Malignant triton tumor is a divergent malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation.
  • We report a case of malignant triton tumor arising in the brachial plexus of a 28-year-old women with neurofibromatosis type 1.
  • Fluorodeoxyglucose-positron emission tomography-computed tomography before excision demonstrated a tumor with a maximum standard uptake value of 21 at 4 hours postinjection.
  • The patient underwent complete excision of the tumor through median sternotomy and left supraclavicular approach.
  • [MeSH-major] Brachial Plexus / pathology. Neurilemmoma / diagnosis. Pancoast Syndrome / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Thoracic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Fluorodeoxyglucose F18. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neurofibromatosis 1 / complications. Positron-Emission Tomography. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 19096322.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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70. Bäck L, Heikkilä T, Passador-Santos F, Saat R, Leivo I, Mäkitie AA: Management of facial nerve schwannoma: A single institution experience. Acta Otolaryngol; 2010 Oct;130(10):1193-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of facial nerve schwannoma: A single institution experience.
  • CONCLUSION: Difficulties in diagnosis, conservative initial steps in the management algorithm and intraoperative risks for facial nerve (FN) injury are divisive features for this tumour entity.
  • One patient is currently under conservative follow-up for a parotid schwannoma (diagnosed with magnetic resonance imaging) with intact FN function.
  • No malignant schwannomas were encountered.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Facial Nerve. Neurilemmoma / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20441526.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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71. White JB, Scheithauer BW, Amrami KK, Babovic-Vuksanovic D, Spinner RJ: Contiguous conventional and plexiform schwannomas. Report of two cases. J Neurosurg; 2006 Feb;104(2):319-24
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  • The authors present clinical, imaging, and histological features of two adult patients found to harbor a conventional schwannoma contiguous with a deep plexiform schwannoma.
  • The proximal forearm lesions consisted of a conventional schwannoma and an underlying plexiform component.
  • The authors believe that a more careful examination of patients with NF2 may show that these people have a higher incidence of plexiform schwannoma than previously thought.
  • Pathological confirmation is crucial in distinguishing plexiform schwannomas from plexiform neurofibromas, because the latter are directly associated with NF1 and have a significant tendency to undergo malignant transformation.
  • To the best of the authors' knowledge, this is the first report of a conventional schwannoma contiguous with a deep plexiform schwannoma.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Neurilemmoma / pathology. Neurofibroma, Plexiform / pathology. Neurofibromatosis 2 / complications
  • [MeSH-minor] Adult. Arm / innervation. Arm / pathology. Cell Transformation, Neoplastic. Functional Laterality. Humans. Male

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  • (PMID = 16509508.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Kandil E, Abdel Khalek M, Abdullah O, Dali D, Faruqui S, Khan A, Friedlander P, Jaffe BM, Crawford B: Primary peripheral nerve sheath tumors of the thyroid gland. Thyroid; 2010 Jun;20(6):583-6
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  • [Title] Primary peripheral nerve sheath tumors of the thyroid gland.
  • BACKGROUND: Primary peripheral nerve sheath tumors (PNSTs) of the thyroid gland are exceptionally rare tumors that usually present as asymptomatic neck nodules in adults.
  • SUMMARY: PNSTs of the thyroid can be classified into benign and malignant.
  • Only three cases of malignant PNSTs have been reported.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery. Neurofibroma / pathology

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  • (PMID = 20553194.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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73. Manganoni AM, Farisoglio C, Lonati A, Zorzi F, Tucci G, Pinton PG: Cutaneous epithelioid malignant schwannoma: review of the literature and case report. J Plast Reconstr Aesthet Surg; 2009 Sep;62(9):e318-21
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  • [Title] Cutaneous epithelioid malignant schwannoma: review of the literature and case report.
  • A case of malignant epithelioid schwannoma in the skin is reported.
  • This was a rare variant of a malignant tumour that arose on the back of a 35-year-old male without neurofibromatosis.
  • Ultrastructural and immunohistochemical features of the lesion were consistent with those of malignant epithelioid schwannoma so a radical excision was performed.
  • Most ordinary malignant schwannoma are located in the deep soft tissue of the proximal portions of the upper and lower extremities and trunk; to the best of our knowledge only 26 cases of malignant epithelioid schwannoma in the skin and subcutis have been described in the literature.
  • We can conclude that malignant epithelioid schwannoma in the skin and subcutis is eminently curable if treated with wide local excision.
  • [MeSH-major] Epithelioid Cells / pathology. Neurilemmoma / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Treatment Outcome

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  • (PMID = 18455973.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 11
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74. Nemec SF, Donat MA, Mehrain S, Friedrich K, Krestan C, Matula C, Imhof H, Czerny C: CT-MR image data fusion for computer assisted navigated neurosurgery of temporal bone tumors. Eur J Radiol; 2007 May;62(2):192-8
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  • The images played a crucial role in the differentiation of benign and malignant pathologies, which consisted of 13 benign and 2 malignant tumors.
  • [MeSH-minor] Adult. Aged. Chondrosarcoma / pathology. Chondrosarcoma / surgery. Female. Glomus Tumor / pathology. Glomus Tumor / surgery. Humans. Image Processing, Computer-Assisted. Intraoperative Period. Male. Melanoma / pathology. Melanoma / surgery. Meningioma / pathology. Meningioma / surgery. Middle Aged. Neurilemmoma / pathology. Neurilemmoma / surgery. Sensitivity and Specificity. Surgery, Computer-Assisted

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  • (PMID = 17229539.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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75. Ndiaye M, Rouleau V, Rame JP, Pescatori P, Denoux Y, Louis MY, De Raucourt D: [Laryngeal schwannoma: a case report and review of the literature]. Rev Laryngol Otol Rhinol (Bord); 2006;127(4):243-6
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  • [Title] [Laryngeal schwannoma: a case report and review of the literature].
  • OBJECTIVES: In presenting a case of laryngeal schwannoma, the authors emphasize the difficulties in diagnosing this rare pathology and review treatment options.
  • MATERIALS AND METHOD: The authors present a case of laryngeal schwannoma in a 29 year old man, revealed by exertional inspiratory dyspnea.
  • The possibility of malignant change and recurrence warrant long-term follow-up.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Dyspnea / etiology. Humans. Laryngectomy. Male

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  • (PMID = 17315789.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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76. Thoennissen NH, Schliemann C, Brunnberg U, Schmidt E, Staebler A, Stegger L, Bremer C, Schleicher C, Mesters RM, Müller-Tidow C, Berdel WE: Chemotherapy in metastatic malignant triton tumor: report on two cases. Oncol Rep; 2007 Oct;18(4):763-7
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  • [Title] Chemotherapy in metastatic malignant triton tumor: report on two cases.
  • Malignant triton tumor (MTT) is a rare, highly malignant nerve sheath tumor with rhabdomyoblastic differentiation.
  • [MeSH-major] Cecal Neoplasms / therapy. Ileal Neoplasms / therapy. Liver Neoplasms / therapy. Neurilemmoma / therapy. Ovarian Neoplasms / drug therapy. Uterine Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Fluorodeoxyglucose F18. Humans. Male. Neoadjuvant Therapy. Neurofibromatosis 1 / pathology. Positron-Emission Tomography. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 17786333.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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77. Gelly-Marty M, Martin E, Assous D, Cuisenier J, Collin F: [Plexiform schwannoma of the delto-pectoral area]. Ann Pathol; 2007 Apr;27(2):133-5
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  • [Title] [Plexiform schwannoma of the delto-pectoral area].
  • Plexiform schwannoma is a form of schwannoma which usually involves cutaneous tissues.
  • It cannot be easily differentiated from malignant tumors, especially deep or cellular lesions.
  • We report a deep plexiform schwannoma which we place among the various benign or malignant nerve sheath tumors, which may or may not develop within the context of genetic disease.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology. Thoracic Wall
  • [MeSH-minor] Humans. Male. Young Adult

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  • (PMID = 17909473.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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78. Xia SY, Li R, Song SB, Liang FQ: [Diagnosis and surgical therapy of primary retroperitoneal neurogenic tumors]. Zhonghua Yi Xue Za Zhi; 2009 Jun 9;89(22):1567-9
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  • [Title] [Diagnosis and surgical therapy of primary retroperitoneal neurogenic tumors].
  • OBJECTIVE: To explore the diagnosis and surgical therapy for retroperitoneal neurogenic tumors (PRNTs).
  • METHODS: The clinical records of 79 surgically treated patients with retroperitoneal neurogenic tumor were retrospectively analyzed.
  • Pathological analysis identified 19 patients with neurofibroma, 8 with neurilemmoma, 4 with paraganglioma, 21 with neurofibrosarcoma, 14 with malignant neurilemmoma, 6 with malignant paraganglioma, 5 with neuroectodermal tumor and 2 with neuroblastoma.
  • The mortality rate of PRNT operation is was 1.3%, 3-year recurrence rate of benign tumor 0%, 5-year recurrence rate of benign tumor 12.9%, reoperation rate 100%, 5-year survival rate 100%.
  • 3 years recurrence rate of malignancy tumor 41.6%, reoperation rate 90%, 5 years recurrence rate of malignancy tumor 79.1% and 5 years survival rate is 62.5%.
  • Pre-operative preparation of intestinal tract and blood, maintaining the intactness of involved nerve are important for tumor resection.
  • To prevent tumor recurrence, the key surgical techniques are to minimize tumor residues and .
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 19953887.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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79. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • No example of melanotic schwannoma was recorded.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Agaram NP, Prakash S, Antonescu CR: Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. Am J Surg Pathol; 2005 Aug;29(8):1042-8
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  • [Title] Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety.
  • Plexiform schwannoma (PS) is one of the least common histologic variants of schwannoma.
  • However, the frequent cellular morphology associated with hyperchromatic nuclei, increased mitoses, and plexiform growth can suggest a malignant process, mainly a high-grade malignant peripheral nerve sheath tumor (MPNST).
  • Fifteen tumors were located in the deep somatic soft tissue (extremities, 8; retroperitoneum/pelvis, 3; trunk, 2; parotid, 1; vulva, 1) and 1 tumor was located in the thoracic esophagus.
  • The 8 superficial PSs showed increased cellularity and mild to moderate pleomorphism in 62% of cases but lacked tumor necrosis.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. S100 Proteins / analysis

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  • (PMID = 16006798.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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81. Saraswathy A, Jayasree RS, Baiju KV, Gupta AK, Pillai VP: Optimum wavelength for the differentiation of brain tumor tissue using autofluorescence spectroscopy. Photomed Laser Surg; 2009 Jun;27(3):425-33
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  • [Title] Optimum wavelength for the differentiation of brain tumor tissue using autofluorescence spectroscopy.
  • OBJECTIVE: The role of autofluorescence spectroscopy in the detection and staging of benign and malignant brain tumors is being investigated in this study, with an additional aim of determining an optimum excitation wavelength for the spectroscopic identification of brain tumors.
  • MATERIALS AND METHODS: The present study involves in-vitro autofluorescence monitoring of different human brain tumor samples to assess their spectroscopic properties.
  • The autofluorescence measurement at four different excitation wavelengths 320, 370, 410, and 470 nm, were carried out for five different brain tumor types: glioma, astrocytoma, meningioma, pituitary adenoma, and schwannoma.
  • RESULTS: The fluorescence spectra of tumor tissues showed significant differences, both in intensity and in spectral profile, from those of adjacent normal brain tissues at all four excitation wavelengths.
  • Of the four excitation wavelengths being considered, 470 nm appeared to be the optimal wavelength for detecting tissue fluorescence of brain tumor tissues.
  • CONCLUSIONS: In conclusion, the spectroscopic luminescence measurements carried out in this study revealed significant differences between tumor tissue and adjacent normal tissue of human brains for all the tumor types tested, except for pituitary adenoma.
  • From the results of this study we conclude that excitation wavelengths ranging from 410-470 nm are most suitable for the detection of brain tumor tissue.
  • [MeSH-minor] Adolescent. Adult. Aged. Algorithms. Astrocytoma / pathology. Child. Child, Preschool. Discriminant Analysis. Female. Glioma / pathology. Humans. Male. Meningioma / pathology. Middle Aged. Neoplasm Staging. Neurilemmoma / pathology. Pituitary Neoplasms / pathology. Principal Component Analysis

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  • (PMID = 19025404.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Sasaki A, Suto T, Nitta H, Shimooki O, Obuchi T, Wakabayashi G: Laparoscopic excision of retroperitoneal tumors: report of three cases. Surg Today; 2010;40(2):176-80
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  • The mean tumor size was 4.8 cm.
  • The postoperative pathological diagnosis was schwannoma in one patient and ganglioneuromas in two.
  • Laparoscopic surgical techniques for retroperitoneal tumors are safe, and their use is encouraged when an appropriate diagnosis is made, after exclusion of malignant subtypes.
  • [MeSH-major] Ganglioneuroma / surgery. Laparoscopy / methods. Neurilemmoma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20107961.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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83. Chijiwa H, Mihoki T, Shin B, Sakamoto K, Umeno H, Nakashima T: Clinical study of parapharyngeal space tumours. J Laryngol Otol Suppl; 2009;(31):100-3
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  • Seventy-seven per cent of the parapharyngeal space tumours were benign and 23 per cent were malignant.
  • A mandibular swing approach was used for one malignant tumour.
  • The most common complication, facial nerve paralysis, was identified in eight patients, and seven of these patients demonstrated first bite syndrome.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Facial Nerve Injuries / etiology. Female. Glossopharyngeal Nerve. Glossopharyngeal Nerve Diseases / surgery. Humans. Hypoglossal Nerve. Hypoglossal Nerve Diseases / surgery. Male. Middle Aged. Pain / etiology. Postoperative Complications / etiology. Syndrome. Vagus Nerve. Vagus Nerve Diseases / surgery. Young Adult

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  • (PMID = 19460214.001).
  • [ISSN] 0144-2945
  • [Journal-full-title] The Journal of laryngology and otology. Supplement
  • [ISO-abbreviation] J Laryngol Otol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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84. Furniss D, Swan MC, Morritt DG, Lim J, Khanna T, Way BL, Athanasou NA, Giele H, Critchley P: A 10-year review of benign and malignant peripheral nerve sheath tumors in a single center: clinical and radiographic features can help to differentiate benign from malignant lesions. Plast Reconstr Surg; 2008 Feb;121(2):529-33
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  • [Title] A 10-year review of benign and malignant peripheral nerve sheath tumors in a single center: clinical and radiographic features can help to differentiate benign from malignant lesions.
  • BACKGROUND: Malignant peripheral nerve sheath tumors are rare, and their aggressive nature mandates treatment in specialist centers.
  • In contrast, benign peripheral nerve sheath tumors are common and are treated by a variety of specialist surgeons, including plastic surgeons.
  • The authors aimed to detect features in the clinical presentation of peripheral nerve sheath tumors that point toward a diagnosis of malignant peripheral nerve sheath tumor and therefore prompt referral to a specialist center.
  • METHODS: All histologically diagnosed primary peripheral nerve sheath tumors from January of 1995 to December of 2004 were identified from histopathology records.
  • RESULTS: During the study period, 32 cases of malignant peripheral nerve sheath tumor in 30 patients were treated.
  • Factors in the clinical evaluation that significantly predicted the presence of malignant peripheral nerve sheath tumor included site, large size, depth in relation to the deep fascia, short duration of symptoms, and pain.
  • Interestingly, schwannomata were harder to distinguish from malignant peripheral nerve sheath tumors both clinically and radiologically.
  • CONCLUSIONS: The authors have reviewed their institutional experience of peripheral nerve sheath tumors over a 10-year period.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neurilemmoma / diagnosis. Neurofibroma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Time Factors

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  • (PMID = 18300972.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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85. Halac M, Cnaral F, Sait S, Ylmaz S, Kerim S, Sergülen D, Uslu I: FDG PET/CT findings in recurrent malignant schwannoma. Clin Nucl Med; 2008 Mar;33(3):172-4
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  • [Title] FDG PET/CT findings in recurrent malignant schwannoma.
  • Malignant schwannoma is an uncommon but aggressive sarcoma that most commonly arises in young and middle-aged adults.
  • We present a 28-year-old male patient with a recurrent chest wall malignant schwannoma.
  • We conclude that FDG PET/CT could play an important role in the staging, restaging, and post-therapy follow-up of malignant schwannomas.
  • [MeSH-major] Fluorodeoxyglucose F18. Muscle Neoplasms / radiography. Muscle Neoplasms / radionuclide imaging. Neurilemmoma / radiography. Neurilemmoma / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Thoracic Wall / radiography. Thoracic Wall / radionuclide imaging. Tomography, Emission-Computed
  • [MeSH-minor] Adult. Axilla / radiography. Axilla / radionuclide imaging. Humans. Male. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging

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  • (PMID = 18287838.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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86. Joseph JA, Jaberoo MC, Sandison A, Grant WE: Benign schwannoma of the tonsil. BMJ Case Rep; 2010;2010
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  • [Title] Benign schwannoma of the tonsil.
  • Tonsillar schwannoma is a slow growing lesion presenting in the third to fifth decade of life.
  • Tonsillar schwannoma can be diagnosed in the outpatient clinic.
  • Schwannoma has the potential for malignant transformation, with no recorded cases of this occurring in the tonsil.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / surgery. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Deglutition Disorders / diagnosis. Deglutition Disorders / etiology. Dysphonia / diagnosis. Dysphonia / etiology. Follow-Up Studies. Humans. Immunohistochemistry. Male. Rare Diseases. Risk Assessment. Tomography, X-Ray Computed / methods. Tonsillectomy / methods. Treatment Outcome. Young Adult

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  • [Cites] J Laryngol Otol. 1999 Jun;113(6):585-6 [10605596.001]
  • [Cites] J Oral Maxillofac Surg. 2001 Jul;59(7):802-4 [11429745.001]
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  • (PMID = 22767561.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029798
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87. Khouni H, Andrianne R, Nidhal H, Badreddine S, de Leval J, Faouzi MA: [Benign schwannoma, a rare retroperitoneal tumour]. Prog Urol; 2005 Feb;15(1):78-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign schwannoma, a rare retroperitoneal tumour].
  • Among retroperitoneal tumours derived from nervous tissue, schwannoma is defined as a tumour arising from neurilemma or Schwann nerve sheath cells.
  • Its diagnosis is immunohistological, and treatment is surgical, consisting of complete resection of the mass due to the risk of malignant degeneration.
  • The immunological and histological study concluded on benign schwannoma.
  • With a postoperative follow-up of two years, the patient has not presented any recurrence of this retroperitoneal schwannoma.
  • [MeSH-major] Neurilemmoma. Retroperitoneal Neoplasms
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 15822399.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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88. Xu D, Liu D, Zhang Z, Zhang Y, Li Y, Liu X, Jia Q, Zheng L, Song G: Gamma Knife surgery in the management of orbital tumors. J Neurosurg; 2010 Dec;113 Suppl:34-8
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  • There were 84 meningiomas, 38 epithelial tumors of the lacrimal gland, 23 schwannomas, 18 malignant choroidal melanomas, 12 optic nerve gliomas, 11 orbital metastases, 10 pseudotumors of the orbit, 3 retinoblastomas, and 3 cases of fibromatosis.
  • The tumor margin dose ranged from 10 to 40 Gy.
  • RESULTS: At a median follow-up period of 34.5 ± 14.7 months (range 12-114 months), tumor shrinkage was observed in 118 patients (58.4%) and stable tumor size in 71 patients (35.1%).
  • Regularly scheduled neuroimaging studies demonstrated evidence of tumor progression in only 13 patients (6.4%): 9 of these patients underwent repeated GKS and 4 received surgical treatment.
  • [MeSH-major] Meningioma / surgery. Neurilemmoma / surgery. Optic Nerve Glioma / surgery. Orbital Neoplasms / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Male. Meningeal Neoplasms / surgery. Middle Aged. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 21121785.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Di Giovannantonio L, Bellocci R, Zappacosta R, Zappacosta B, Castrataro A, Liberatore M, Liberati M, Angelucci D: [Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report]. Pathologica; 2005 Feb;97(1):7-9
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  • [Title] [Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report].
  • [Transliterated title] Schwannoma maligno primitivo della cervice uterina: un tumore maligno a comportamento inusuale. Caso clinico.
  • Malignant tumors of peripheral nerves (MPNST) represent approximately 5-10% of all soft tissue sarcomas and usually are in relationship with a major nerve.
  • Primary cervical malignant Schwannomas are very rare neural sheat tumors that, grossly and clinically, are misdiagnosed for other more frequent lesions of the uterine cervix.
  • We report a case of primary cervical malignant Schwannoma in a 27 years old female with atypical bleeding.
  • [MeSH-major] Neurilemmoma / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans


90. Kim CS, Suh MW: Skull base surgery for removal of temporal bone tumors. Acta Otolaryngol Suppl; 2007 Oct;(558):4-14
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  • CONCLUSION: When selecting the appropriate surgical approach the pathological type of tumor, the physiological status as well as the functional aspects should be considered.
  • Understanding the strengths and weaknesses of each surgical technique and knowledge of the particular tumor biology facilitates selection of the most appropriate surgical approach and a successful outcome.
  • A facial nerve schwannoma was the most common benign intratemporal tumor and a squamous cell carcinoma was the most common malignant tumor.
  • With the facial nerve schwannoma, facial nerve paralysis and hearing loss were the most common presenting complaints; otalgia was the most common presenting symptom for temporal bone cancer.
  • For patients with a glomus tumor, there was a characteristic pulsating tinnitus.
  • A majority of the facial nerve schwannomas were resectable through the transmastoid approach.
  • The infratemporal fossa approach type A was usually required for lower cranial nerve schwannomas and glomus jugulare tumors.
  • [MeSH-minor] Adolescent. Adult. Cerebrospinal Fluid Otorrhea / etiology. Child. Child, Preschool. Cranial Nerve Neoplasms / surgery. Dizziness / etiology. Earache / etiology. Facial Nerve Diseases / surgery. Facial Paralysis / etiology. Female. Glomus Tumor / blood supply. Glomus Tumor / surgery. Hearing Loss / etiology. Hoarseness / etiology. Humans. Infant. Male. Middle Aged. Muscle Weakness. Neurilemmoma / surgery. Retrospective Studies. Tinnitus / etiology. Vertigo / etiology

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  • (PMID = 17882564.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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91. Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E: Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature. J Cutan Pathol; 2010 Sep;37(9):997-1001
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  • [Title] Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
  • Neuroblastoma-like schwannoma was first described by Goldblum et al. in 1994, and very few cases have since been reported.
  • It is a benign sporadic neoplasm with no reported association with neurofibromatosis, and is characterized histologically by small round lesional cells surrounding collagenous cores forming rosette-like structures.
  • The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Neuroblastoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Treatment Outcome

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  • (PMID = 19922484.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Sengöz A, Taşdemiroğlu E, Togay H: Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report. Neurosurg Focus; 2006;21(6):E11
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  • [Title] Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report.
  • The authors present a case of clear cell sarcoma (CCS) in which the tumor originated in the S-1 nerve root and had been previously diagnosed as psammomatous melanotic schwannoma (PMS).
  • This is the third case of a spinal nerve root origin for CCS reported in the English-language literature.
  • The similar histogenesis of CCS and malignant melanoma supports the hypothesis that biological agents or immunotherapy are potentially important areas of investigation.
  • The border of the resection was extended 1 cm distal to the tumor margin.
  • The new histopathological diagnosis was CCS (malignant melanoma of soft tissue).
  • A CCS originating from peripheral nerves is quite rare.
  • [MeSH-major] Neurilemmoma / classification. Peripheral Nervous System Neoplasms / classification. Sarcoma, Clear Cell / classification. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm. Biomarkers, Tumor / analysis. Breast Neoplasms. Diagnosis, Differential. Diagnostic Errors. Female. Fibroadenoma. Humans. Keratins / analysis. Male. Melanins / analysis. Melanoma-Specific Antigens. Neoplasm Invasiveness. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local. Neoplasms, Multiple Primary. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / genetics. Nerve Sheath Neoplasms / pathology. Pigmentation Disorders / diagnosis. Pigmentation Disorders / genetics. Prognosis. S100 Proteins / analysis. Sacrococcygeal Region. Syndrome. Vimentin / analysis

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  • (PMID = 17341045.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanins; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 17
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93. Chiofalo MG, Longo F, Marone U, Franco R, Petrillo A, Pezzullo L: Cervical vagal schwannoma. A case report. Acta Otorhinolaryngol Ital; 2009 Feb;29(1):33-5
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  • [Title] Cervical vagal schwannoma. A case report.
  • Schwannoma originating from the cervical vagus nerve is an extremely rare neoplasm.
  • Vagal nerve schwannoma usually occurs between the third and fifth decades of life, it does not show sex predilection both sexes being equally affected and it most often presents as a painless, slow-growing, lateral neck mass.
  • A case of a cervical vagal schwannoma, in a 33-year old male with a previous medical history of malignant lymphoma, is described.
  • The clinical features, diagnosis, management and pathological findings of cervical vagal schwannoma are discussed.
  • [MeSH-major] Cranial Nerve Neoplasms. Neurilemmoma. Vagus Nerve Diseases
  • [MeSH-minor] Adult. Humans. Male

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  • [Cites] J Laryngol Otol. 2000 Feb;114(2):119-24 [10748827.001]
  • [Cites] Neurosurgery. 2000 Jun;46(6):1498-503 [10834653.001]
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  • (PMID = 19609380.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2689565
  • [Keywords] NOTNLM ; Benign tumours / Magnetic Resonance imaging / Schwannoma / Vagus nerve
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94. Deniz K, Kontas O, Tucer B, Kurtsoy A: Meningeal solitary fibrous tumor: report of a case and literature review. Folia Neuropathol; 2005;43(3):178-85
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  • [Title] Meningeal solitary fibrous tumor: report of a case and literature review.
  • Solitary fibrous tumor is a rare neoplasm that most often involves the pleura.
  • The increasing numbers of this neoplasm have also been reported to date in extrapleural sites.
  • Histologically, the tumor composed of spindle cell proliferation.
  • Tumor cells were found to be positive for CD34 and CD117 with immunohistochemical studies.
  • Seventy seven cases of meningeal solitary fibrous tumor from the literature are analysed and pathological, immunohistochemical and clinical features are discussed.
  • Solitary fibrous tumor has a slight female predominance, with a male to female ratio of 1:1.5.
  • CD117-positivity can be a good strategy for treatment in malignant and recurrent cases.

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  • (PMID = 16245214.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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95. Aron M, Kapila K, Verma K: Neural tumours of the neck presenting as thyroid nodules: a report of three cases. Cytopathology; 2005 Aug;16(4):206-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report two cases of schwannoma and one case of a malignant peripheral nerve sheath tumour (MPNST) of the neck, which presented as thyroid nodules and evaluate the role of cytology in identifying these tumours.
  • RESULTS: Both the cases of schwannoma were correctly identified on cytology while the case of MPNST could only be typed as a spindle cell tumour.
  • CONCLUSIONS: Schwannomas of the neck are easily identifiable on cytology compared with MPNST.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / diagnosis. Thyroid Gland / pathology
  • [MeSH-minor] Adult. Cytodiagnosis. Diagnosis, Differential. Female. Goiter, Nodular / diagnosis. Humans. Male

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  • (PMID = 16048507.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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96. Gudena V, Verma N, Post G, Kizziah M, Fenning R, Montero AJ: Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review. Cancer Biol Ther; 2008 Jun;7(6):810-3
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  • [Title] Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review.
  • Malignant schwannomas or malignant peripheral nerve sheath tumors (MPNST) represent approximately 10% of all soft tissue sarcomas.
  • Metastatic disease from chest wall MPNST is very rare.
  • We present a case of a major clinical response to the tyrosine kinase inhibitor (TKI) sorafenib in a patient with metastatic MPNST.
  • A 42-year-old female with a prior history of neurofibromas developed MPNST, which later metastasized to the lungs and brain.
  • MPNST show high levels of Ras activity and hence these tumors are promising targets for TKIs.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzenesulfonates / therapeutic use. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / drug therapy. Neurilemmoma / diagnosis. Neurilemmoma / drug therapy. Pyridines / therapeutic use. Thoracic Wall / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / drug therapy. Brain Neoplasms / secondary. Female. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Neoplasm Metastasis. Niacinamide / analogs & derivatives. Phenylurea Compounds. Protein Kinase Inhibitors / therapeutic use. Radiography, Thoracic. Treatment Outcome

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  • (PMID = 18376142.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Protein Kinase Inhibitors; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
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97. James G, Crocker M, King A, Bodi I, Ibrahim A, Chitnavis BP: Malignant triton tumors of the spine. J Neurosurg Spine; 2008 Jun;8(6):567-73
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  • [Title] Malignant triton tumors of the spine.
  • Malignant triton tumors (MTTs) are malignant peripheral nerve sheath tumors with rhabdomyosarcomatous differentiation.
  • Malignant triton tumors affecting the spine are rare but present special challenges to the neurosurgeon.
  • Nine patients presented with symptoms related to the spinal cord, cauda equina, or nerve root compression.
  • Seven patients had intradural extension of tumor.
  • Malignant triton tumors are rare but should be included in the differential diagnosis of spinal tumors, particularly in patients who have undergone previous radiotherapy or who have neurofibromatosis.
  • [MeSH-major] Neurilemmoma / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Desmin / analysis. Diagnosis, Differential. Female. Humans. Ki-67 Antigen / analysis. Lumbar Vertebrae / pathology. Male. Neoplasm Recurrence, Local / diagnosis. S100 Proteins / analysis. Sacrum / pathology. Spinal Canal / pathology. Spinal Cord Compression / diagnosis. Thoracic Vertebrae / pathology. Vimentin / analysis

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  • (PMID = 18518679.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Desmin; 0 / Ki-67 Antigen; 0 / S100 Proteins; 0 / Vimentin
  • [Number-of-references] 13
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98. Agarwal K, Agarwal C, Agarwal M, Harbhajanka A: Plexiform schwannoma of scalp: a case report with brief review of literature. Indian J Pathol Microbiol; 2007 Oct;50(4):797-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plexiform schwannoma of scalp: a case report with brief review of literature.
  • Plexiform schwannoma is a morphologically distinct and rare variant of schwannoma.
  • It is a benign tumor and malignant transformation has not been reported.
  • We are presenting a case of plexiform schwannoma occurring on scalp and measuring 8cm in size because of its rarity and unusual size.
  • [MeSH-major] Neurilemmoma / diagnosis. Neurilemmoma / pathology. Scalp / pathology
  • [MeSH-minor] Adult. Biopsy. Humans. Male

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  • (PMID = 18306559.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 15
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99. Trufant JW, Brenn T, Fletcher CD, Virata AR, Cook DL, Bosenberg MW: Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism. Am J Dermatopathol; 2009 Dec;31(8):808-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism.
  • Melanotic schwannoma is a rare markedly pigmented peripheral nerve sheath tumor comprising cells with prominent melanization and schwannian features.
  • We present the first 2 reported cases of melanotic schwannoma arising in patients with a history of nevus of Ota, a rare dermal melanosis believed to represent a failure of melanocyte migration to the epidermis during embryogenesis.
  • Case 1 involves a 40-year-old woman with a 1.8-cm, deeply pigmented, trigeminal nerve mass and pigmentation of the maxillary sinus mucosa and bone.
  • Microscopically, both masses consist of partially encapsulated epithelioid and spindle cells with abundant melanin pigment, arising in association with peripheral nerves.
  • Morphological, immunohistochemical, and ultrastructural features support a diagnosis of melanotic schwannoma.
  • Melanotic schwannoma is most often benign but has been associated with malignant behavior in some cases.
  • Distinguishing this nerve sheath tumor from malignant melanoma can be difficult but is of great clinical importance due to differences in prognosis and treatment.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Nevus of Ota / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Melanins. Middle Aged


100. Mathieu D, Kondziolka D, Flickinger JC, Niranjan A, Williamson R, Martin JJ, Lunsford LD: Stereotactic radiosurgery for vestibular schwannomas in patients with neurofibromatosis type 2: an analysis of tumor control, complications, and hearing preservation rates. Neurosurgery; 2007 Mar;60(3):460-8; discussion 468-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiosurgery for vestibular schwannomas in patients with neurofibromatosis type 2: an analysis of tumor control, complications, and hearing preservation rates.
  • We evaluated the results of gamma knife radiosurgery for the management of these tumors, focusing on tumor response, hearing preservation, and other factors affecting outcomes.
  • The mean tumor volume was 5.7 cm3.
  • Tumor volume was significant as a predictor of local control.
  • Radiation dose and tumor volume were predictive of development of new deficits.
  • No radiosurgery-associated secondary tumors or atypical or malignant changes were noted.
  • Although results do not seem to be as good as for patients with sporadic unilateral tumors, gamma knife radiosurgery results seem favorable and indicate that radiosurgery should be strongly considered for primary tumor management in selected patients.
  • [MeSH-major] Hearing Loss, Sensorineural / epidemiology. Hearing Loss, Sensorineural / prevention & control. Neurilemmoma / epidemiology. Neurilemmoma / surgery. Neurofibromatosis 2 / epidemiology. Neurofibromatosis 2 / surgery. Radiosurgery / statistics & numerical data
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Incidence. Male. Middle Aged. Pennsylvania / epidemiology. Retrospective Studies. Risk Assessment / methods. Risk Factors. Treatment Outcome






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