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1. Dwarakanath S, Suri A, Sharma BS, Mehta VS: Intracranial hemangioblastomas: an institutional experience. Neurol India; 2006 Sep;54(3):276-8
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  • [Title] Intracranial hemangioblastomas: an institutional experience.
  • BACKGROUND AND AIMS: We present our Institutional experience with intracranial hemangioblastomas.
  • MATERIALS AND METHODS: This study included all patients of intracranial hemangioblastomas admitted in our institution over a period of 11 years from January 1992 through June 2003.
  • The tumor was located in the cerebellar hemispheres, vermian and brainstem regions in 42 (60%) patients, 19 (28%) patients and 8 (12%) patients, respectively.
  • Thirty-three patients underwent CSF diversion procedures prior to surgery on the tumor.
  • Sixty eight patients underwent surgery on the tumor.
  • [MeSH-major] Brain Neoplasms. Hemangioblastoma. Institutional Practice / statistics & numerical data
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Male. Retrospective Studies. von Hippel-Lindau Disease / etiology

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  • (PMID = 16936388.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
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2. Jang SY, Kong MH, Song KY, Frazee JG: Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult. J Korean Neurosurg Soc; 2009 Jun;45(6):381-5

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  • [Title] Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult.
  • The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report.
  • The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II).
  • When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

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  • (PMID = 19609424.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2711238
  • [Keywords] NOTNLM ; Astrocytoma / Cranial metastases / Intramedullary / Spinal cord tumor
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3. Naggara O, Brami-Zylberberg F, Rodrigo S, Raynal M, Meary E, Godon-Hardy S, Oppenheim C, Meder JF: [Imaging of intracranial metastases in adults]. J Radiol; 2006 Jun;87(6 Pt 2):792-806
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  • [Title] [Imaging of intracranial metastases in adults].
  • Intracranial metastases account for up to 35% of intracranial tumors in adult.
  • Any systemic tumor can metastasize to the brain; the most common primaries include lung, breast and melanoma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / secondary

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  • (PMID = 16778748.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 30
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4. Li HM, Hsu SS, Wang JS, Weng MJ, Fu JH, Chen CK, Lai PH: Cerebral pilocytic astrocytoma with spontaneous intracranial hemorrhage in adults. J Chin Med Assoc; 2008 Nov;71(11):587-93
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  • [Title] Cerebral pilocytic astrocytoma with spontaneous intracranial hemorrhage in adults.
  • We report 2 cases of adult pilocytic astrocytoma with intracranial hemorrhage.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a well-enhanced and circumscribed cystic hemorrhagic tumor with mural nodule over the cerebral hemisphere region.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Cerebral Hemorrhage / etiology
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 19015059.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
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5. Stienen MN, Hermann C, Breuer T, Gautschi OP: [Pott's puffy tumor - severe course of a sinusitis]. Praxis (Bern 1994); 2010 Apr 28;99(9):555-60
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  • [Title] [Pott's puffy tumor - severe course of a sinusitis].
  • [Transliterated title] Pott's puffy-Tumor - Schwerer Verlauf einer Sinusitis.
  • Here, we present a complicated case with intracranial dissemination.
  • [MeSH-minor] Adult. Anti-Bacterial Agents / administration & dosage. Anti-Bacterial Agents / therapeutic use. Brain Abscess / etiology. Craniotomy. Emergencies. Empyema, Subdural / etiology. Hospitalization. Humans. Length of Stay. Magnetic Resonance Imaging. Male. Meningoencephalitis / complications. Meningoencephalitis / diagnosis. Meningoencephalitis / surgery. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 20449824.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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6. Bi WL, Bannykh SI, Baehring J: The Growing Teratoma Syndrome after Subtotal Resection of an Intracranial Nongerminomatous Germ Cell Tumor in an Adult: Case Report. Neurosurgery; 2005 Jan 01;56(1):E191-E194

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  • [Title] The Growing Teratoma Syndrome after Subtotal Resection of an Intracranial Nongerminomatous Germ Cell Tumor in an Adult: Case Report.

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  • (PMID = 28184632.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Becker H: [Intracerebral hemorrhage misjudged as tumor]. Clin Neuroradiol; 2010 Aug;20(3):161-4
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  • [Title] [Intracerebral hemorrhage misjudged as tumor].
  • [Transliterated title] Intrazerebrale Blutung als Tumor verkannt.
  • The patient was informed that she had a tumor.
  • With further increase of intracranial pressure, a craniotomy was done and a hemorrhage was removed.
  • [MeSH-major] Brain Neoplasms / radiography. Cerebral Hemorrhage / radiography. Diagnostic Errors / prevention & control. Hemangioma, Cavernous, Central Nervous System / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 20625692.001).
  • [ISSN] 1869-1447
  • [Journal-full-title] Clinical neuroradiology
  • [ISO-abbreviation] Clin Neuroradiol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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8. Saada J, Enza-Razavi F, Delahaye S, Martinovic J, Macaleese J, Benachi A: Early second-trimester diagnosis of intracranial teratoma. Ultrasound Obstet Gynecol; 2009 Jan;33(1):109-11
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  • [Title] Early second-trimester diagnosis of intracranial teratoma.
  • We report a case of an intracranial tumor diagnosed in the early second trimester.
  • The diagnosis had been suspected at first-trimester routine sonography, which showed a compressive intracranial mass with mild vascularization.
  • [MeSH-major] Brain Neoplasms / ultrasonography. Fetal Diseases / ultrasonography. Hydrocephalus / ultrasonography. Teratoma / ultrasonography
  • [MeSH-minor] Abortion, Eugenic. Adult. Early Diagnosis. Female. Humans. Pregnancy. Pregnancy Trimester, Second. Ultrasonography, Prenatal

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  • [Copyright] Copyright (c) 2008 ISUOG.
  • (PMID = 18991328.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Cunliffe CH, Fischer I, Monoky D, Law M, Revercomb C, Elrich S, Kopp MJ, Zagzag D: Intracranial lesions mimicking neoplasms. Arch Pathol Lab Med; 2009 Jan;133(1):101-23
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  • [Title] Intracranial lesions mimicking neoplasms.
  • CONTEXT: A broad spectrum of nonneoplastic conditions can mimic a brain tumor, both clinically and radiologically.
  • OBJECTIVE: To illustrate the radiologic and pathologic features of nontumoral intracranial lesions that can clinically and radiologically mimic neoplasia.
  • [MeSH-major] Brain Diseases / diagnosis. Brain Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19123722.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Kaylie DM, Warren FM 3rd, Haynes DS, Jackson CG: Neurotologic management of intracranial epidermoid tumors. Laryngoscope; 2005 Jun;115(6):1082-6
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  • [Title] Neurotologic management of intracranial epidermoid tumors.
  • OBJECTIVES: Epidermoid cysts are the most common intracranial embryonal tumor, although they account for only 1% of all intracranial tumors.
  • Epidermoids often spread into several intracranial compartments.
  • This paper discusses the neurotologic management of intracranial epidermoid cysts STUDY DESIGN: Retrospective chart review.
  • METHODS: A database search revealed 10 patients with diagnosis of intracranial epidermoid cysts between January 1, 1971 and December 31, 2003 at our institution.
  • The average tumor size was 3.9 cm; six originated in the cerebellopontine angle and four in the petrous apex.
  • Six patients had a translabyrinthine approach to the tumor, two with additional transcochlear exposure.
  • Multiple cranial nerves were involved by tumor in all patients, including nerves III through XI.
  • The internal carotid artery was involved by tumor in four patients.
  • Eight patients required intradural access for complete tumor removal.
  • Seven had complete tumor removal.
  • CONCLUSIONS: Intracranial epidermoid cysts require complex surgical planning.
  • [MeSH-minor] Adolescent. Adult. Cerebellar Diseases / surgery. Cerebellopontine Angle. Female. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Retrospective Studies

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  • (PMID = 15933526.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Levine S, Garfein ES, Weiner H, Yaremchuk MJ, Saadeh PB, Gurtner G, Levine JP, Warren SM: Intracranial microvascular free flaps. J Reconstr Microsurg; 2009 Feb;25(2):89-95
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  • [Title] Intracranial microvascular free flaps.
  • Large acquired intracranial defects can result from trauma or surgery.
  • When reoperation is required because of infection or tumor recurrence, management of the intracranial dead space can be challenging.
  • By providing well-vascularized bulky tissue, intracranial microvascular free flaps offer potential solutions to these life-threatening complications.
  • A multi-institutional retrospective chart and radiographic review was performed of all patients who underwent microvascular free-flap surgery for salvage treatment of postoperative intracranial infections between 1998 and 2006.
  • A total of six patients were identified with large intracranial defects and postoperative intracranial infections.
  • Four patients had parenchymal resections for tumor or seizure and two patients had posttraumatic encephalomalacia.
  • All patients underwent operative debridement and intracranial free-flap reconstruction using the latissimus dorsi muscle (N=2), rectus abdominis muscle (N=2), or omentum (N=2).
  • We concluded that surgery or trauma can result in significant intracranial dead space.
  • Treatment of postoperative intracranial infection can be challenging.
  • The early use of this technique when intracranial dead space and infection coexist is beneficial.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Infection / surgery. Postoperative Complications / surgery. Reconstructive Surgical Procedures / methods. Skull / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adult. Child. Combined Modality Therapy. Debridement. Humans. Male. Middle Aged. Retrospective Studies. Salvage Therapy. Treatment Outcome


12. Tun K, Ozen O, Kaptanoglu E, Gurcan O, Beskonakli E, Celasun B: Primary intracranial low-grade fibromyxoid sarcoma (Evans tumor). J Clin Neurosci; 2008 Nov;15(11):1298-301

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  • [Title] Primary intracranial low-grade fibromyxoid sarcoma (Evans tumor).
  • Low-grade fibromyxoid sarcoma was first described in 1987 as a rare soft tissue neoplasm characterized by a bland and deceptively benign histological appearance but with aggressive behavior.
  • A right frontal mass was detected on MRI and he was operated upon to remove the intracranial mass.
  • Although primary intracranial low-grade fibromyxoid sarcoma has characteristic histological features, clinical and radiological correlation is necessary to make the correct diagnosis.
  • [MeSH-major] Fibrosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Young Adult

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  • (PMID = 18771926.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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13. Tufan K, Dogulu F, Kurt G, Emmez H, Ceviker N, Baykaner MK: Intracranial meningiomas of childhood and adolescence. Pediatr Neurosurg; 2005 Jan-Feb;41(1):1-7
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  • [Title] Intracranial meningiomas of childhood and adolescence.
  • Meningiomas are rare intracranial neoplasms in childhood and adolescence, representing 0.4-4.1% of the pediatric-age tumors and 1.5-1.8% of all intracranial meningiomas.
  • Patients operated for intracranial meningiomas of childhood and adolescence between 1983 and 2003 at Gazi University School of Medicine, Department of Neurosurgery, were evaluated retrospectively.
  • Atypical and malignant meningiomas seem to be more common in childhood and adolescence with respect to adult meningiomas.
  • Tumor location, completeness of tumor removal, and pathological grade are the most important prognostic factors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / surgery. Meningioma / diagnosis. Meningioma / surgery

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15886506.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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14. Yang JJ, Xiang Y, Yang XY, Wan XR: Emergency craniotomy in patients with intracranial metastatic gestational trophoblastic tumor. Int J Gynaecol Obstet; 2005 Apr;89(1):35-8
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  • [Title] Emergency craniotomy in patients with intracranial metastatic gestational trophoblastic tumor.
  • OBJECTIVE: To study the diagnosis, management and prognosis of intracranial metastases of gestational trophoblastic tumor (GTT) patients who had emergency craniotomy.
  • METHODS: Sixty three intracranial metastases of GTT patients were hospitalized in Peking Union Medical College Hospital from 1985 to 2004.
  • Thirteen of them had craniotomy that were retrospectively analyzed and all of them had a feature of raised intracranial pressure followed by intracranial hemorrhagic mass.
  • An undetermined intracranial hemorrhage in young female patients of a reproductive age group should raise the suspicion of cerebral metastatic GTT.
  • [MeSH-major] Brain Neoplasms / surgery. Craniotomy. Gestational Trophoblastic Disease / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Emergencies. Female. Humans. Intracranial Hemorrhages / etiology. Intracranial Hemorrhages / surgery. Intracranial Hypertension / etiology. Intracranial Hypertension / surgery. Pregnancy. Prognosis. Remission Induction. Retrospective Studies

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  • (PMID = 15777896.001).
  • [ISSN] 0020-7292
  • [Journal-full-title] International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • [ISO-abbreviation] Int J Gynaecol Obstet
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Pfister SM, Remke M, Benner A, Werft W, Mendrzyk F, Scheurlen W, Kulozik A, Lichter P, Korshunov A: Use of CDK6 oncogene amplification and 17q gain to predict poor clinical risk groups in adult medulloblastoma. J Clin Oncol; 2009 May 20;27(15_suppl):2030

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of CDK6 oncogene amplification and 17q gain to predict poor clinical risk groups in adult medulloblastoma.
  • : 2030 Background: While in children medulloblastoma comprises the most common malignant brain tumor, it accounts for only 1% of intracranial malignancies in adults.
  • METHODS: Array-CGH was performed for a total 34 adult medulloblastoma samples (>18 years) and results were compared with data from 101 pediatric patients.
  • Selected genomic regions were further investigated by FISH analysis in an independent cohort of 415 samples (112 adult and 303 pediatric).
  • All 146 adult patients received a standard treatment regimen consisting of tumor resection, irradiation of the neuroaxis with 36 Gy, a boost of 20-23 Gy to the posterior fossa, and eight cycles of vincristin, lomustine, and cisplatin.
  • RESULTS: Copy-number gains of chromosome 17q as well as high-level amplifications of CDK6 were identified as significant adverse prognostic markers in adult medulloblastoma.
  • Apart from one exception, CDK6 amplifications were only observed in adult patients (9% in adults versus 0.2 % in children), whereas amplifications of MYC or MYCN were significantly overrepresented in the pediatric cohort, but when present were also associated with dismal prognosis in adults.
  • Based on these results, we propose a molecular staging system for adult medulloblastoma: i) cases with oncogene amplification (10% of cases, 5-year OS = 0%);.
  • CONCLUSIONS: We report on the largest cohort of adult medulloblastoma investigated for genomic imbalances to date.
  • We propose a model for the molecular risk stratification of adult medulloblastoma comprising three distinct genomic risk groups with significantly different survival and tumor biology.

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  • (PMID = 27964634.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Ding XH, Zhou LF, Tan YZ, Zhao Y, Zhu JJ: Histologic and histogenetic investigations of intracranial hemangioblastomas. Surg Neurol; 2007 Mar;67(3):239-45; discussion 245
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  • [Title] Histologic and histogenetic investigations of intracranial hemangioblastomas.
  • BACKGROUND: The aim of this study was to elucidate the histologic characteristics and the histogenesis of intracranial HBs.
  • Stromal cells are the real tumor components of HBs although they represent a heterogeneity.
  • [MeSH-major] Cerebellar Neoplasms. Hemangioblastoma
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD34 / immunology. Cells, Cultured. Endothelium, Vascular / immunology. Endothelium, Vascular / ultrastructure. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Pericytes / immunology. Pericytes / ultrastructure. Stromal Cells / immunology. Stromal Cells / ultrastructure. Telomerase / immunology

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  • (PMID = 17320626.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.7.7.49 / Telomerase
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17. Erdoğan N, Tucer B, Mavili E, Menkü A, Kurtsoy A: Ultrasound guidance in intracranial tumor resection: correlation with postoperative magnetic resonance findings. Acta Radiol; 2005 Nov;46(7):743-9
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  • [Title] Ultrasound guidance in intracranial tumor resection: correlation with postoperative magnetic resonance findings.
  • PURPOSE: To determine the inter-method agreement between intraoperative ultrasonography and postoperative contrast-enhanced magnetic resonance imaging (MRI) in detecting tumor residue.
  • Any echogenic region >5 mm in thickness extending from the surgical cavity into the brain substance was taken as the sonographic criterion for residual tumor.
  • CONCLUSION: Intraoperative ultrasound is an effective tool for maximizing the extent of intracranial tumor resection.
  • [MeSH-major] Brain Neoplasms / surgery. Brain Neoplasms / ultrasonography. Magnetic Resonance Imaging. Neoplasm, Residual / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Contrast Media. Female. Gadolinium. Glioblastoma / surgery. Humans. Intraoperative Period. Male. Middle Aged. Postoperative Period. Treatment Outcome

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  • (PMID = 16372696.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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18. Bi WL, Bannykh SI, Baehring J: The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report. Neurosurgery; 2005;56(1):188
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report.
  • OBJECTIVE AND IMPORTANCE: We report a rare complication after resection of a recurrent intracranial nongerminomatous germ cell tumor in an adult.
  • The growing teratoma syndrome, as originally described with pediatric germ cell neoplasms, represents tumor recurrence, often cystic, that sometimes is observed after partial response to multimodality therapy and despite decreasing tumor serum markers.
  • The enlarging tumor consists of elements of a mature teratoma that presumably are refractory to chemotherapy or radiation.
  • To our knowledge, this is only the third case of the growing teratoma syndrome in an adult patient with nongerminomatous germ cell tumor.
  • CLINICAL PRESENTATION: A 26-year-old man had signs of recurrent obstructive hydrocephalus 6 months after multimodality treatment of a diencephalic yolk sac tumor and endoscopic third ventriculostomy.
  • Imaging studies revealed large multilocular cystic masses originating from the tumor bed and partially obstructing the ventriculostomy.
  • INTERVENTION: Near total tumor resection and fenestration was performed.
  • [MeSH-major] Brain Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / surgery. Neoplasms, Second Primary / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Adult. Humans. Male. Syndrome

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  • (PMID = 15617603.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Modena P, Lualdi E, Facchinetti F, Veltman J, Reid JF, Minardi S, Janssen I, Giangaspero F, Forni M, Finocchiaro G, Genitori L, Giordano F, Riccardi R, Schoenmakers EF, Massimino M, Sozzi G: Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics. J Clin Oncol; 2006 Nov 20;24(33):5223-33
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  • [Title] Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics.
  • PURPOSE: To delineate clinically relevant molecular signatures of intracranial ependymoma.
  • MATERIALS AND METHODS: We analyzed 24 primary intracranial ependymomas.
  • We identified specific differentially imbalanced genomic clones and gene expression signatures significantly associated with tumor location, patient age at disease onset, and retrospective risk for relapse.
  • Integrated genomic and expression profiling allowed us to identify genes of which the expression is deregulated in intracranial ependymoma, such as overexpression of the putative proto-oncogene YAP1 (located at 11q22) and downregulation of the SULT4A1 gene (at 22q13.3).
  • [MeSH-major] Brain Neoplasms / genetics. Ependymoma / genetics. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adolescent. Adult. Child. Child, Preschool. DNA Methylation. Down-Regulation. Female. Gene Expression Profiling. Humans. In Situ Hybridization, Fluorescence. Infant. Loss of Heterozygosity. Male. Oligonucleotide Array Sequence Analysis. Phosphoproteins / genetics. Reverse Transcriptase Polymerase Chain Reaction. Sulfotransferases / genetics. Up-Regulation

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  • (PMID = 17114655.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Phosphoproteins; 0 / YAP1 (Yes-associated) protein, human; EC 2.8.2 / SULT4A1 protein, human; EC 2.8.2.- / Sulfotransferases
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20. Shen C, Xie R, Bao WM, Guo QH, Yu G, Cao XY, Yang BJ, Mao Y: [Preoperative and postoperative assessment of memory function for intracranial tumor patients]. Zhonghua Yi Xue Za Zhi; 2010 Feb 2;90(5):301-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Preoperative and postoperative assessment of memory function for intracranial tumor patients].
  • OBJECTIVE: To analyze the effects of intracranial tumors and tumor resection on patients' memory functions.
  • METHODS: Four different memory scales were employed to evaluate 58 intracranial tumor patients' memory functions including short-term memory, delayed memory, clue memory and long-term memory.
  • RESULTS: The extra-cerebral tumor patients presented with delayed memory and long-term memory disorders while intra-cerebral tumor patients suffered from short-term, delayed and severe long-term memory disorders.
  • Sellar region tumors and transsphenoidal tumor resection had no effects upon memory functions.
  • CONCLUSION: Intracranial tumors cause memory disorders.
  • Tumor resection decreases long-term memory functions.
  • [MeSH-major] Brain Neoplasms / psychology. Memory Disorders / etiology. Postoperative Complications / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Case-Control Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 20368049.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Uysal A, Oztekin O, Oztekin D, Polat M: Prenatal diagnosis of a fetal intracranial tumor. Arch Gynecol Obstet; 2005 Jun;272(1):87-9
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  • [Title] Prenatal diagnosis of a fetal intracranial tumor.
  • INTRODUCTION: The commonest fetal intracranial tumor is the teratoma.
  • CASE REPORT: A fetus with a congenital intracranial teratoma presenting with a disproportionately enlarged head at 36 weeks' gestation is presented.
  • This article describes the prenatal sonographic diagnosis of a rare case of intracranial immature teratoma in a fetus at 36 weeks' gestation.
  • [MeSH-major] Brain Neoplasms / ultrasonography. Teratoma / ultrasonography. Ultrasonography, Prenatal
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Infant, Newborn. Pregnancy. Pregnancy Trimester, Third

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  • (PMID = 15309403.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Massimino M, Buttarelli FR, Antonelli M, Gandola L, Modena P, Giangaspero F: Intracranial ependymoma: factors affecting outcome. Future Oncol; 2009 Mar;5(2):207-16
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  • [Title] Intracranial ependymoma: factors affecting outcome.
  • Ependymomas account for 2-9% of all neuroepithelial tumors, amounting to 6-12% of all intracranial tumors in children and up to 30% of those in children younger than 3 years.
  • Recent findings provide evidence that intracranial and spinal ependymomas share similar molecular profiles with the radial glia of their corresponding locations.
  • The management of intracranial ependymoma is still not optimal.
  • For high-risk patients, with residual tumor, an interesting, although experimental, approach could be chemotherapy followed by secondary surgery and postoperative conformal irradiation.
  • [MeSH-major] Brain Neoplasms / pathology. Ependymoma / pathology
  • [MeSH-minor] Adult. Biomarkers / analysis. Child. Humans. Prognosis

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  • (PMID = 19284379.001).
  • [ISSN] 1744-8301
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers
  • [Number-of-references] 68
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23. Schuurmans M, Vanneste JA, Verstegen MJ, van Furth WR: Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases. J Neurooncol; 2006 Aug;79(1):57-9
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  • [Title] Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases.
  • Magnetic resonance imaging (MRI) of the cervical spine revealed an extramedullary tumor with severe spinal cord compression.
  • During surgery an intradural extramedullary tumor was found.
  • Further imaging showed a second lumbar spinal tumor.
  • Two years after surgery, an intracranial extracerebral metastasis was found, without evidence of spinal recurrence.
  • [MeSH-major] Brain Neoplasms / secondary. Ependymoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cervical Vertebrae. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Lumbar Vertebrae. Magnetic Resonance Imaging. S100 Proteins / metabolism

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  • (PMID = 16614942.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / S100 Proteins
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24. Rousseau A, Bernier M, Kujas M, Varlet P: Primary intracranial melanocytic tumor simulating pituitary macroadenoma: case report and review of the literature. Neurosurgery; 2005 Aug;57(2):E369; discussion E369
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  • [Title] Primary intracranial melanocytic tumor simulating pituitary macroadenoma: case report and review of the literature.
  • OBJECTIVE AND IMPORTANCE: Primary intracranial melanocytic tumors are rare lesions, sellar ones being even more exceptional.
  • INTERVENTION: A gross subtotal resection of a hemorrhagic tumor was performed.
  • Histological examination revealed melanin-laden pleomorphic tumor cells that tested positive for HMB-45 and S-100 and negative for cytokeratins, thus demonstrating that the tumor was a melanocytic neoplasm.
  • CONCLUSION: Primary sellar melanocytic neoplasms are extremely rare lesions and present with few differential diagnoses.
  • Deciding whether the tumor is best classified as a melanocytoma or a melanoma may prove difficult.
  • [MeSH-major] Adenoma / diagnosis. Melanoma / surgery. Meningeal Neoplasms / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Antigens, Neoplasm. Female. Humans. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. S100 Proteins / metabolism

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  • (PMID = 16094139.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
  • [Number-of-references] 27
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25. Metellus P, Barrie M, Figarella-Branger D, Chinot O, Giorgi R, Jouvet A, Guyotat J: [Intracranial ependymomas in adult patients. Retrospective analysis of 121 cases from the multicentric French study]. Neurochirurgie; 2007 Jun;53(2-3 Pt 1):66-75
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  • [Title] [Intracranial ependymomas in adult patients. Retrospective analysis of 121 cases from the multicentric French study].
  • Ependymomas are rare intracranial tumors observed in adults.
  • We report a retrospective study of 121 cases intracranial ependymomas diagnosed between 1990 and 2004 in adult patients.
  • This study demonstrated that extent of surgery and tumor grade are the two main prognostic factors in adult intracranial ependymomas with respect to overall and progression-free survival.
  • [MeSH-major] Brain Neoplasms / pathology. Ependymoma / pathology. Neurosurgical Procedures / methods
  • [MeSH-minor] Disease-Free Survival. Female. Follow-Up Studies. France / epidemiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Neoplasm, Residual / epidemiology. Retrospective Studies

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  • (PMID = 17475290.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
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26. Chen YC, Tang LM, Chen CJ, Jung SM, Chen ST: Intracranial hypertension as an initial manifestation of spinal neuroectodermal tumor. Clin Neurol Neurosurg; 2005 Aug;107(5):408-11
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  • [Title] Intracranial hypertension as an initial manifestation of spinal neuroectodermal tumor.
  • Cerebrospinal fluid study showed intracranial hypertension (IH), hypoglycorrhachia, hyperproteinorrhachia, and a negative cytology study.
  • Biopsy of the mass showed primitive neuroectodermal tumor (PNET).
  • IH rarely occurs in patients with spinal cord neoplasms.
  • Spinal tumor should be considered in IH patients whose intracranial examinations are negative.
  • [MeSH-major] Intracranial Hypertension / etiology. Neuroectodermal Tumors, Primitive / physiopathology. Pregnancy Complications, Neoplastic / physiopathology. Spinal Cord Neoplasms / physiopathology
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Thoracic Vertebrae

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  • (PMID = 16023536.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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27. Tanaka M, Imhof HG, Schucknecht B, Kollias S, Yonekawa Y, Valavanis A: Correlation between the efferent venous drainage of the tumor and peritumoral edema in intracranial meningiomas: superselective angiographic analysis of 25 cases. J Neurosurg; 2006 Mar;104(3):382-8
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  • [Title] Correlation between the efferent venous drainage of the tumor and peritumoral edema in intracranial meningiomas: superselective angiographic analysis of 25 cases.
  • The authors studied the correlation between the development of efferent venous drainage from the tumor and the degree of PTBE that occurs in intracranial meningiomas.
  • METHODS: Twenty-five patients with 27 intracranial supratentorial meningiomas were investigated to identify the correlation between the efferent venous drainage system of the tumor and peritumoral edema.
  • In each meningioma, superselective angiography of the dominant feeding artery was performed, including the late venous phase to evaluate the development of the tumor's draining vein.
  • Eleven meningiomas (41%), in which the mean EI was 0.14 +/- 0.10, clearly showed dominant draining veins originating from the tumor itself.
  • In the other 16 meningiomas (59%), superselective angiography demonstrated no efferent venous drainage from the tumor, which could account for this group's mean EI value of 1.49 +/- 1.05 (p < 0.001).
  • [MeSH-major] Brain Edema / etiology. Meningeal Neoplasms / blood supply. Meningeal Neoplasms / complications. Meningioma / blood supply. Meningioma / complications
  • [MeSH-minor] Adult. Aged. Cerebral Angiography. Female. Humans. Male. Middle Aged. Regional Blood Flow

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  • (PMID = 16572650.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Kim SD, Park JY, Choi WS, Kim SH, Lim DJ, Chung HS: Intracranial recurrence of the scalp dermatofibrosarcoma. Clin Neurol Neurosurg; 2007 Feb;109(2):172-5
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  • [Title] Intracranial recurrence of the scalp dermatofibrosarcoma.
  • Despite surgical intervention and radiotherapy, a recurrent tumor associated with infiltration to the calvarium was detected.
  • Two years later, however, the patient was readmitted to our institution as a result of tumor recurrence with intracranial involvement.
  • Scalp dermatofibrosarcoma is an uncommon but aggressive scalp tumor; therefore, wide local excision with good margins is essential to decrease the risk of regional recurrence.
  • Close surveillance in these cases is necessary due to late tumor recurrences.
  • [MeSH-major] Cranial Sinuses / surgery. Dermatofibrosarcoma / surgery. Neoplasm Recurrence, Local / surgery. Scalp / surgery. Skin Neoplasms / surgery. Skull Neoplasms / secondary
  • [MeSH-minor] Adult. Benzamides. Chemotherapy, Adjuvant. Combined Modality Therapy. Embolization, Therapeutic. Female. Humans. Imatinib Mesylate. Magnetic Resonance Imaging. Neoadjuvant Therapy. Neoplasm Invasiveness. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Reoperation

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  • (PMID = 16757109.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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29. Husain N, Kumari M, Husain M: Tumor irrigation fluid enhances diagnostic efficacy in endoscopic biopsies of intracranial space-occupying lesions. Acta Neurochir (Wien); 2010 Jan;152(1):111-7
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  • [Title] Tumor irrigation fluid enhances diagnostic efficacy in endoscopic biopsies of intracranial space-occupying lesions.
  • We have attempted to increase cellular yield using tumor irrigation fluid (TIF) and a cyto-histological approach for diagnosis of intracranial tumors, cysts, and infections.
  • METHODS: A retrospective group of 147 cases, where only endoscopic biopsies were obtained, was compared with a prospective group of 31 cases where along with the endoscopic biopsies, tumor irrigation fluid (TIF) was collected.
  • Tumor cyst fluid was obtained from cystic tumors (n=6).
  • Small tumor fragments in the TIF were utilized to make squash smears (n=31).
  • Centrifuged deposit smears were prepared from tumor irrigation fluid and tumor cyst fluid.
  • [MeSH-major] Biopsy / methods. Brain Diseases / pathology. Brain Neoplasms / pathology. Cysts / pathology. Endoscopy. Infection / pathology. Therapeutic Irrigation
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Prospective Studies. Retrospective Studies. Young Adult


30. Kawabata Y, Takahashi JA, Arakawa Y, Hashimoto N: Long-term outcome in patients harboring intracranial ependymoma. J Neurosurg; 2005 Jul;103(1):31-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcome in patients harboring intracranial ependymoma.
  • OBJECT: The prognostic significance of tumor grade and resection and the efficacy of prophylactic radiation remain controversial in the management of intracranial ependymoma.
  • The outcomes in patients with intracranial ependymoma treated at the Kyoto University Hospital were reviewed retrospectively, and prognostic significance was analyzed.
  • Overall survival and progression-free survival rates were significantly higher in patients with Grade II ependymoma (p = 0.006 and 0.004, respectively) and in patients who had undergone gross-total resection of the tumor (p = 0.002 and 0.04, respectively).
  • In nine patients the ependymoma recurred only at the original tumor site.
  • All relapses of the Grade II ependymoma initially occurred at the primary tumor site.
  • Histological grade and extent of resection were significantly associated with tumor dissemination (p = 0.0034 and 0.0011, respectively).
  • CONCLUSIONS: Tumor grade and resection are the two important prognostic factors with respect to patient survival, tumor recurrence, and tumor dissemination.
  • [MeSH-major] Brain Neoplasms / mortality. Brain Neoplasms / therapy. Ependymoma / mortality. Ependymoma / therapy. Neoplasm Recurrence, Local / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2006 Sep;105(3):503; author reply 503-4 [16961153.001]
  • [CommentIn] J Neurosurg. 2005 Jul;103(1):4; discussion 4-5 [16121965.001]
  • (PMID = 16121970.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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31. Saito R, Kumabe T, Watanabe M, Jokura H, Shibuya M, Nakazato Y, Tominaga T: Low-grade fibromyxoid sarcoma of intracranial origin. J Neurosurg; 2008 Apr;108(4):798-802
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  • [Title] Low-grade fibromyxoid sarcoma of intracranial origin.
  • The low-grade fibromyxoid sarcoma is a rare sarcoma of the deep soft tissue that is characterized as an indolent but metastasizing soft-tissue neoplasm with a deceptively benign histological appearance.
  • Only one case of intracranial origin has been previously reported in the literature.
  • A high rate of local recurrence and eventual metastasis has been demonstrated for this tumor in deep soft tissue.
  • The tumor is still under control without any evidence of extracranial metastasis.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Sarcoma / diagnosis. Sarcoma / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Radiosurgery. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 18377261.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Karmakar S, Olive MF, Banik NL, Ray SK: Intracranial stereotaxic cannulation for development of orthotopic glioblastoma allograft in Sprague-Dawley rats and histoimmunopathological characterization of the brain tumor. Neurochem Res; 2007 Dec;32(12):2235-42
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  • [Title] Intracranial stereotaxic cannulation for development of orthotopic glioblastoma allograft in Sprague-Dawley rats and histoimmunopathological characterization of the brain tumor.
  • Glioblastoma is the most common brain tumor that causes significant mortality annually.
  • In the present investigation, we successfully implanted rat C6 cells via intracranial stereotaxic cannulation in adult Sprague-Dawley rats for development and histoimmunopathological characterization of an advanced orthotopic glioblastoma allograft model, which could be useful for investigating the course of glioblastoma development as well as for testing efficacy of new therapeutic agents.
  • The orthotopic glioblastoma allograft was generated by intracerebral injection of rat C6 cells through a guide-cannula system and after 21 post-inoculation days the brain tumor was characterized by histoimmunopathological experiments.
  • Our investigation indicated the successful development of intracranial cannulated orthotopic glioblastoma allograft in adult Sprague-Dawley rats, making it as a useful animal model of glioblastoma for pre-clinical evaluation of various therapeutic strategies for the management of glioblastoma.
  • [MeSH-major] Brain Neoplasms / pathology. Glioblastoma / pathology. Neoplasm Transplantation / methods
  • [MeSH-minor] Animals. Biomarkers, Tumor. Catheterization / methods. Cell Transplantation / instrumentation. Cell Transplantation / methods. Coloring Agents. Fluorescent Antibody Technique. Immunohistochemistry. In Situ Hybridization. Male. Rats. Rats, Sprague-Dawley. Stereotaxic Techniques

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  • (PMID = 17701349.001).
  • [ISSN] 0364-3190
  • [Journal-full-title] Neurochemical research
  • [ISO-abbreviation] Neurochem. Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / C06 RR015455; United States / NINDS NIH HHS / NS / NS-57811; United States / NCI NIH HHS / CA / R01 CA-91460
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Coloring Agents
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33. Kim IY, Jung S, Jung TY, Kang SS, Moon KS, Joo SP: Intracranial tuberculoma with adjacent inflammatory aneurysms. J Clin Neurosci; 2008 Oct;15(10):1174-6
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  • [Title] Intracranial tuberculoma with adjacent inflammatory aneurysms.
  • We describe for the first time a case of intracranial tuberculoma with adjacent intracerebral inflammatory aneurysms, and include a brief discussion of the developmental mechanism of these pathologies.
  • [MeSH-major] Brain Diseases / pathology. Intracranial Aneurysm / etiology. Parietal Lobe / pathology. Tuberculoma, Intracranial / complications
  • [MeSH-minor] Adult. Aneurysm, Infected / etiology. Aneurysm, Infected / therapy. Female. Humans. Inflammation / complications. Treatment Outcome

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  • (PMID = 18706816.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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34. Beppu T, Ogasawara K, Ogawa A: Alleviation of intracranial air using carbon dioxide gas during intraventricular tumor resection. Clin Neurol Neurosurg; 2006 Oct;108(7):655-60
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  • [Title] Alleviation of intracranial air using carbon dioxide gas during intraventricular tumor resection.
  • OBJECTIVES/PURPOSES: Postoperative vomiting occurs more frequently in patients after intraventricular surgery than after other intracranial surgeries.
  • This has been attributed to intracranial air.
  • We therefore, attempted to replace air with CO2 during intra- and paraventricular tumor resections.
  • The aim of the present study was to elucidate whether intracranial air after intraventricular surgery could be alleviated safely using CO2, and investigate its clinical usefulness.
  • CONCLUSION: Intracranial air after intraventricular surgery can be safety alleviated using CO2.
  • [MeSH-major] Carbon Dioxide / therapeutic use. Cerebral Ventricle Neoplasms / surgery. Cerebral Ventricles / surgery. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Pneumocephalus / prevention & control
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Fourth Ventricle / pathology. Fourth Ventricle / radiography. Fourth Ventricle / surgery. Germinoma / pathology. Germinoma / radiography. Germinoma / surgery. Glioma, Subependymal / pathology. Glioma, Subependymal / radiography. Glioma, Subependymal / surgery. Humans. Infant. Male. Middle Aged. Neurocytoma / pathology. Neurocytoma / radiography. Neurocytoma / surgery. Postoperative Nausea and Vomiting / etiology. Postoperative Nausea and Vomiting / physiopathology. Postoperative Nausea and Vomiting / prevention & control. Subdural Space / anatomy & histology. Subdural Space / physiology. Subdural Space / surgery. Third Ventricle / pathology. Third Ventricle / radiography. Third Ventricle / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16483713.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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35. Chamberlain MC, Glantz MJ: Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. Neurosurgery; 2008 Oct;63(4):720-6; author reply 726-7
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  • [Title] Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma.
  • OBJECTIVE: Hemangiopericytoma (HPC) is an uncommon primary brain tumor with an almost invariable tendency to recur and metastasize.
  • We undertook a retrospectively collected case series of recurrent intracranial HPCs treated with salvage chemotherapy with the primary objective of evaluating progression-free survival.
  • Eight patients developed disseminated disease, all with multifocal intracranial disease (5 with cerebrospinal fluid dissemination, 4 with extraneural metastases).
  • CONCLUSION: Salvage chemotherapy demonstrated modest efficacy with acceptable toxicity in this cohort of adult patients with recurrent surgery- and radiotherapy-refractory intracranial HPC.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Hemangiopericytoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Salvage Therapy / methods
  • [MeSH-minor] Adult. Cisplatin / adverse effects. Cisplatin / therapeutic use. Cyclophosphamide / adverse effects. Cyclophosphamide / therapeutic use. Cytarabine / administration & dosage. Disease Progression. Disease-Free Survival. Doxorubicin / adverse effects. Doxorubicin / therapeutic use. Drug Administration Routes. Drug Administration Schedule. Etoposide / adverse effects. Etoposide / therapeutic use. Female. Humans. Ifosfamide / adverse effects. Ifosfamide / therapeutic use. Interferon-alpha / administration & dosage. Kaplan-Meier Estimate. Liposomes. Magnetic Resonance Spectroscopy. Male. Middle Aged. Positron-Emission Tomography. Rare Diseases. Retrospective Studies. Survival Rate. Treatment Outcome. Vincristine / adverse effects. Vincristine / therapeutic use

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  • (PMID = 18981882.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon-alpha; 0 / Liposomes; 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; CAV protocol; ICE protocol 1
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36. Johnson N, Sermer M, Lausman A, Maxwell C: Obstetric outcomes of women with intracranial neoplasms. Int J Gynaecol Obstet; 2009 Apr;105(1):56-9
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  • [Title] Obstetric outcomes of women with intracranial neoplasms.
  • OBJECTIVE: To determine the obstetric outcomes of women diagnosed with a primary intracranial neoplasm prior to or during pregnancy and the puerperium.
  • Thirteen patients were diagnosed prior to pregnancy (group 1); tumor growth or recurrence during pregnancy occurred in 3 patients.
  • [MeSH-major] Brain Neoplasms / complications. Pregnancy Complications, Neoplastic / physiopathology. Pregnancy Outcome
  • [MeSH-minor] Adult. Cesarean Section / statistics & numerical data. Databases, Factual. Female. Glioma / complications. Glioma / physiopathology. Glioma / surgery. Humans. Infant, Newborn. Intensive Care Units, Neonatal / statistics & numerical data. Meningioma / complications. Meningioma / physiopathology. Meningioma / surgery. Neoplasm Recurrence, Local / epidemiology. Ontario / epidemiology. Postpartum Period. Pregnancy. Premature Birth / etiology. Retrospective Studies. Vision Disorders / epidemiology. Vision Disorders / etiology

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  • (PMID = 19155008.001).
  • [ISSN] 1879-3479
  • [Journal-full-title] International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • [ISO-abbreviation] Int J Gynaecol Obstet
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Asano K, Kikuchi J, Munakata A, Ohkuma H, Kubo O: An infant case of intracranial peripheral-type primitive neuroectodermal tumor with long-term survival. Brain Tumor Pathol; 2007;24(2):69-74
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  • [Title] An infant case of intracranial peripheral-type primitive neuroectodermal tumor with long-term survival.
  • P-PNET is fundamentally a malignant tumor, but the patient reported here represents a case of long-term survival from onset without recurrence.
  • At the age of 21 months, a male infant developed a cranial bone deformity and symptoms of high intracranial pressure.
  • A CT scan revealed a cystic tumor attaching to the falx, and cyst drainage operation was immediately performed.
  • The intracranial tumor was then resected.
  • The tumor was an intradural extramedullary tumor, and it was totally excised with the falx attachment.
  • The tumor was initially diagnosed as a neuroblastoma, and postoperative treatment consisted of administration of radiotherapy and chemotherapy using cyclophosphamide and vincristine.
  • That is, in spite of the fact that P-PNET is a malignant tumor, patient survival can be comparatively long.
  • Because P-PNET originates intracranially, it is fundamentally an intradural extramedullary tumor.
  • [MeSH-major] Diagnostic Errors. Neuroblastoma / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Supratentorial Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Immunohistochemistry. Infant. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Radiotherapy. Tomography, X-Ray Computed

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  • (PMID = 18095134.001).
  • [ISSN] 1433-7398
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Adame N, Hedlund G, Byington CL: Sinogenic intracranial empyema in children. Pediatrics; 2005 Sep;116(3):e461-7
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  • [Title] Sinogenic intracranial empyema in children.
  • BACKGROUND: Sinogenic intracranial empyema (SIE) is an uncommon complication of sinusitis that can lead to devastating neurologic sequelae.
  • Physical findings included abnormal neurologic examination (9), Pott's puffy tumor (4), and orbital cellulitis (3).
  • The initial facial/orbital imaging studies in 2 patients with physical signs of complicated sinusitis (orbital cellulitis and Pott's puffy tumor) were not adequate to detect SIE.
  • CONCLUSIONS: Children with sinusitis and any neurologic finding, signs of complicated sinusitis such as Pott's puffy tumor or orbital cellulitis, or persistent headache, fever, or nausea and vomiting after antibiotic therapy should have additional evaluation for SIE.
  • [MeSH-minor] Adolescent. Adult. Biomarkers / blood. Blood Sedimentation. C-Reactive Protein / analysis. Child. Female. Humans. Male

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  • (PMID = 16140693.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 9007-41-4 / C-Reactive Protein
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39. Kano H, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD: Outcome predictors for intracranial ependymoma radiosurgery. Neurosurgery; 2009 Feb;64(2):279-87; discussion 287-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome predictors for intracranial ependymoma radiosurgery.
  • OBJECTIVE: To develop outcome predictors after stereotactic radiosurgery (SRS) in patients with intracranial ependymomas who had received previous fractionated radiation therapy, we compared tumor control, survival, and complications with tumor grade, volume, age of patients, and imaging characteristics.
  • Lower histological tumor grade was not significantly associated with better progression-free survival (P = 0.725).
  • Factors associated with an improved progression-free survival included smaller tumor volume and homogeneous tumor contrast enhancement in low-grade ependymomas.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / surgery. Ependymoma / epidemiology. Ependymoma / surgery. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Outcome Assessment (Health Care) / methods. Radiosurgery / statistics & numerical data
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Incidence. Male. Middle Aged. Pennsylvania / epidemiology. Retrospective Studies. Risk Assessment / methods. Risk Factors. Treatment Outcome. Young Adult

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  • (PMID = 19190457.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Lee JW, Kang KW, Park SH, Lee SM, Paeng JC, Chung JK, Lee MC, Lee DS: 18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma. Eur J Nucl Med Mol Imaging; 2009 Oct;36(10):1574-82
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  • [Title] 18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma.
  • METHODS: Fifty-nine patients (27 men and 32 women) with intracranial meningioma who underwent preoperative FDG PET and subsequent surgical resection were enrolled.
  • All patients underwent clinical follow-up for tumor recurrence with a mean duration of 34+/-20 months.
  • The tumor to gray matter ratio (TGR) of FDG uptake was calculated and a receiver-operating characteristic (ROC) curve of the TGR was drawn to determine the cutoff value of the TGR for detection of high-grade meningioma.
  • RESULTS: The TGR in high-grade meningioma (WHO grade II and III) was significantly higher than that in low-grade ones (WHO grade I) (p=0.002) and significantly correlated with the MIB-1 labeling index (r=0.338, p=0.009) and mitotic count of the tumor (r=0.284, p=0.03).
  • In the log-rank test, the TGR, MIB-1 labeling index, presence of brain invasion, and WHO grade were significantly associated with tumor recurrence.
  • The cumulative recurrence-free survival rate of patients with a TGR of 1.0 or less was significantly higher than that of patients with a TGR of more than 1.0 (p=0.0003) CONCLUSION: FDG uptake in meningioma was the significant predictive factor of tumor recurrence and significantly correlated with the proliferative potential of the tumor.
  • [MeSH-major] Brain Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18. Meningioma / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Fluorine Radioisotopes. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography. ROC Curve

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  • (PMID = 19377904.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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41. Andreu Martínez FJ, Martínez Mateu JM: Intracranial germ cell tumor mimicking anorexia nervosa. Clin Transl Oncol; 2006 Dec;8(12):915-8
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  • [Title] Intracranial germ cell tumor mimicking anorexia nervosa.
  • This case shows that the presence of intracranial tumours next to the hypothalamus must be borne in mind as a rare but real possibility in cases of anorexia nervosa, specially in those non-typical cases.
  • [MeSH-major] Anorexia Nervosa / pathology. Brain Neoplasms / pathology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Amenorrhea / etiology. Anorexia / etiology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasms, Germ Cell and Embryonal / complications. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / therapy. Radiotherapy

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  • (PMID = 17169766.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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42. Suwonpanich P, Laothamatas J: Magnetic resonance venography in intracranial veno-occlusive disease. J Med Assoc Thai; 2007 May;90(5):913-7
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  • [Title] Magnetic resonance venography in intracranial veno-occlusive disease.
  • OBJECTIVE: To identify the common MR Vfindings in the patient diagnosed intracranial veno-occlusive disease at Ramathibodi Hospital and to identify the underlying conditions that probably predisposed the patient to the intracranial veno-occlusive disease.
  • MATERIAL AND METHOD: Sixty-four patients with clinically suggestive intracranial veno-occlusive disease who underwent MRV were reviewed in terms of signs and symptoms, MRV methods, MRV findings, and clinical diagnosis after report MRV In cases diagnosed to have intracranial veno-occlusive disease, the patients' records were reviewed to identify predisposing conditions.
  • RESULTS: Thirty-four patients were diagnosed to have intracranial veno-occlusive disease.
  • Contributing factors in patients diagnosed to have intracranial veno-occlusive disease in the present series were birth control pill in take, tumor (meningioma, and malignant schwannoma of the scalp), blood dyscrasia, AVM, hypotension, and abscess.
  • The causes of intracranial venous thrombosis could not be identified in seven patients (21%).
  • CONCLUSION: The common MR Vfinding in acute intracranial veno-occlusive disease was lack of typical high flow signal from a sinus while frayed appearance of flow signal from a sinus was the common direct sign in chronic condition.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Phlebography. Retrospective Studies

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  • (PMID = 17596045.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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43. Koizumi K, Abe E, Kusanagi Y, Ito M: Giant immature intracranial teratoma with antenatal cranial perforation. J Obstet Gynaecol Res; 2010 Dec;36(6):1252-5
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  • [Title] Giant immature intracranial teratoma with antenatal cranial perforation.
  • Here we present a congenital intracranial immature teratoma, which was prenatally diagnosed.
  • Prenatal ultrasonography and fetal magnetic resonance imaging detected the presence of a massive, heterogeneous intracranial tumor at 26 weeks gestational age.
  • An intracranial tumor lacking normal intracranial structures was detected.
  • Ultrasonography and magnetic resonance imaging are helpful in the prenatal diagnosis and evaluation of intracranial tumors.
  • [MeSH-major] Brain Neoplasms / ultrasonography. Fetal Diseases / ultrasonography. Skull / pathology. Teratoma / ultrasonography
  • [MeSH-minor] Female. Fetal Death. Humans. Pregnancy. Young Adult

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  • [Copyright] © 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.
  • (PMID = 21040207.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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44. Bolat F, Kayaselcuk F, Tarim E, Kilicdag E, Bal N: Congenital intracranial teratoma with massive macrocephaly and skull rupture. Fetal Diagn Ther; 2008;23(1):1-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital intracranial teratoma with massive macrocephaly and skull rupture.
  • OBJECTIVE: Congenital intracranial tumors are rare and only account for 0.5-1.5% of all pediatric brain tumors.
  • Teratoma is the most frequently encountered intracranial tumor at birth.
  • Massive congenital intracranial teratoma is an extremely rare neoplasm with a poor prognosis.
  • Herein we report a massive intracranial teratoma causing skull rupture.
  • CASE REPORT: A fetus with a congenital intracranial teratoma presenting with a disproportionately enlarged head at 25 weeks of gestation is presented.
  • Prenatal ultrasonography demonstrated a huge, heterogeneous intracranial mass, and midline structures and ventricles could not be observed.
  • Autopsy was perforated, and histopathologic examination of the samples taken from the intracranial mass revealed an immature teratoma.
  • CONCLUSION: Although congenital intracranial teratomas are rare, they may reach enormous sizes.
  • Regular follow-up of the fetus may lead to early diagnosis of immature intracranial teratomas and prevent the mother from having further complications either due to intrauterine fetal death orpsychological trauma of giving birth to a heavily malformed baby.
  • [MeSH-major] Brain Neoplasms / pathology. Hydrocephalus / pathology. Skull / pathology. Teratoma / pathology
  • [MeSH-minor] Adult. Female. Fetal Death / etiology. Fetal Death / pathology. Fetal Diseases / pathology. Humans. Pregnancy. Prenatal Diagnosis / methods. Rupture / complications. Rupture / pathology

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  • [Copyright] (c) 2007 S. Karger AG, Basel
  • (PMID = 17934288.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 19
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45. Marakovic J, Vilendecic M, Marinovic T, Lambasa S, Grahovac G: Intracranial recurrence and distant metastasis of scalp dermatofibrosarcoma protuberans. J Neurooncol; 2008 Jul;88(3):305-8
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  • [Title] Intracranial recurrence and distant metastasis of scalp dermatofibrosarcoma protuberans.
  • Only few cases of scalp dermatofibrosarcoma protuberans with intracranial and distant metastasis have been reported.
  • Here we report a case of scalp dermatofibrosarcoma protuberans with frequent local recurrence, intracranial invasion and with distant lung metastasis during 6 years of treatment.
  • Close surveillance of patients with scalp dermatofibrosarcoma is necessary due recurrence nature of tumor.
  • [MeSH-major] Dermatofibrosarcoma / secondary. Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / pathology. Scalp / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male


46. Yao B, Li JJ, Liu X, Li WM, Yan JH, Weng JP: [The clinical characteristics of primary intracranial germinoma]. Zhonghua Nei Ke Za Zhi; 2005 Nov;44(11):840-3
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  • [Title] [The clinical characteristics of primary intracranial germinoma].
  • OBJECTIVE: To analyse the clinical characteristics of intracranial germinoma.
  • METHODS: Retrospective analysis was applied to study the clinical characteristics of 26 intracranial germ cell tumor patients admitted to our hospital during 1991-2003.
  • RESULTS: 26 intracranial germ cell tumor patients were admitted to our hospital during 1991-2003, accounting for 0.9% of all intracranial tumors (3020 cases) at the same time.
  • Among these patients 19 cases (73.1%) were primary intracranial germinoma, 9 patients (47.4%) were female and 10 patients (52.6%) were male.
  • CONCLUSIONS: Intracranial germinoma mainly affects female children and adolescents, pine and suprasellar regions are the commonly involved regions, the most common manifestations of intracranial germinoma are headache, vomiting, nausea, diabetes insipidus and hypopituitarism.
  • Radiotherapy has good efficacy in the treatment of intracranial germinoma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Germinoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Child. Chorionic Gonadotropin, beta Subunit, Human / blood. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. alpha-Fetoproteins / analysis

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  • (PMID = 16316566.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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47. Metellus P, Nanni I, Dussert C, Trinkhaus M, Fuentes S, Chinot O, Ouafik LH, Fina F, Dufour H, Figarella-Branger D, Grisoli F, Lah TT, Martin PM: [Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]. Neurochirurgie; 2008 Dec;54(6):750-6
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  • [Title] [Prognostic implications of biologic markers in intracranial meningiomas: 120 cases].
  • The recurrence and progression of treated intracranial meningiomas highlights the problem of the type of follow-up that should be used and whether early complementary treatment is indicated.
  • The aim of this study was to evaluate different biochemical markers involved in cell proliferation and transformation to identify new prognostic factors in intracranial meningiomas.
  • Between 1989 and 2003, 120 intracranial meningiomas were studied biochemically.
  • The levels of estrogen receptors (RE), progesterone receptors (RP), cathepsin B (CB), cathepsin L (CL), stefin A (ATA), stefin B (STB), cystatin C (CYSC), urokinase (u-PA), type 1 plasminogen activator inhibitors (PAI-1), cathepsin D (CD) and thymidine kinase activity (TK) were measured in tumor extracts using biochemical assays.
  • Monofactorial analysis showed that expression of progesterone receptors (RP) had an inverse correlation with recurrence (p=0.0025 %) and that thymidine kinase activity (TK), cathepsin L (CL), the WHO grade and the degree of tumor resection correlated with recurrence (p<0.05).
  • The results of this study confirm the importance of biological parameters (PR, CL, TK) as prognostic factors for the risk of recurrence in intracranial meningiomas.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Discriminant Analysis. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 18760426.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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48. Dobec-Meić B, Pikija S, Cvetko D, Trkulja V, Pazanin L, Kudelić N, Rotim K, Pavlicek I, Kostanjevec AR: Intracranial tumors in adult population of the Varazdin County (Croatia) 1996-2004: a population-based retrospective incidence study. J Neurooncol; 2006 Jul;78(3):303-10
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  • [Title] Intracranial tumors in adult population of the Varazdin County (Croatia) 1996-2004: a population-based retrospective incidence study.
  • AIM: To estimate the incidence of intracranial tumors in the adult population of the Varazdin County, Croatia, for the 1996-2004 period.
  • Incident patients: county residents admitted for newly diagnosed intracranial tumors according to the WHO diagnostic criteria.
  • RESULTS: For primary intracranial tumors (PITs), IR was 12.1/100,000 p-y (95% CI: 10.3-14.2), comparable in men and women.
  • Annual IRs for all these tumor categories showed increasing trends over the study period.
  • CONCLUSION: Overall, there was an increasing trend in the incidence of primary intracranial tumors in the Varazdin County.
  • Data did not allow estimation for most of the specific tumor types.
  • [MeSH-major] Brain Neoplasms / epidemiology. Glioblastoma / epidemiology. Meningioma / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Cohort Studies. Confidence Intervals. Croatia / epidemiology. Female. Humans. Incidence. Male. Middle Aged. Retrospective Studies. Sex Distribution. Statistics, Nonparametric

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  • (PMID = 16598428.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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49. Li F, Zhu G, Lin J, Meng H, Wu N, Du Y, Feng H: Photodynamic therapy increases brain edema and intracranial pressure in a rabbit brain tumor model. Acta Neurochir Suppl; 2006;96:422-5
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  • [Title] Photodynamic therapy increases brain edema and intracranial pressure in a rabbit brain tumor model.
  • The objective of this study was to evaluate the effect of a single photodynamic therapy (PDT) on brain edema and intracranial pressure (ICP) in a rabbit model of brain tumor.
  • A total of 57 adult New Zealand rabbits were assigned to 3 groups: the PDT group, the tumor group, and the tumor plus PDT group.
  • Rabbits in the PDT group (n = 9) received PDT but no tumor implantation; rabbits in the tumor group (n = 18) received VX2 carcinoma implantation but no PDT; rabbits in the tumor plus PDT group (n = 30) received tumor implantation with subsequent PDT 16 days later.
  • After tumor implantation, ICP increased rapidly (18.43 +/- 1.10 mmHg, 21 days later).
  • PDT alone did not increase ICP, but compared with that in the tumor group, ICP increased significantly in the tumor plus PDT group (9.55 +/- 1.32 vs. 13.31 +/- 1.13 mmHg, p < 0.01) 24 hours after treatment.
  • Brain water content in the tumor group increased rapidly after tumor implantation.
  • In conclusion, PDT causes transient brain edema and increases ICP in a rabbit brain tumor model.
  • [MeSH-major] Brain Edema / chemically induced. Brain Neoplasms / drug therapy. Intracranial Hypertension / chemically induced. Intracranial Pressure / drug effects. Photochemotherapy / adverse effects. Porphyrins / adverse effects

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  • (PMID = 16671498.001).
  • [ISSN] 0065-1419
  • [Journal-full-title] Acta neurochirurgica. Supplement
  • [ISO-abbreviation] Acta Neurochir. Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins
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50. Lakhdar F, Laghmari M, Gana R, Maaqili R, Bellakhdar F: [Multiple intracranial ganglioglioma. Case report]. Neurochirurgie; 2008 Apr;54(2):97-100
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  • [Title] [Multiple intracranial ganglioglioma. Case report].
  • Multiple intracranial ganglioglioma (GG) is an extremely rare condition, generally associated with van Recklinghausen neurofibromatosis.
  • We report the case of a 26-year-old woman who presented with progressive tetraparesis, raised intracranial pressure and visual loss.
  • In patients with multiple cerebral tumors, search for multiple ganglioglioma is particularly important because of the therapeutic implications and the good prognosis of this tumor.
  • [MeSH-major] Brain Neoplasms / pathology. Ganglioglioma / pathology
  • [MeSH-minor] Adult. Biopsy. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Intracranial Hypertension / etiology. Mesencephalon / pathology. Quadriplegia / etiology. Temporal Lobe / pathology. Tomography, X-Ray Computed. Visual Pathways / pathology

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  • (PMID = 18355879.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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51. Lakhdar F, Arkha Y, El Ouahabi A, Melhaoui A, Rifi L, Derraz S, El Khamlichi A: Intracranial meningioma in children: different from adult forms? A series of 21 cases. Neurochirurgie; 2010 Aug;56(4):309-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial meningioma in children: different from adult forms? A series of 21 cases.
  • OBJECTIVE: Intracranial meningiomas are very rare in children, comprising only 0.4 to 4.1% of pediatric tumors and only 1.5 to 1.8% to all intracranial meningiomas.
  • The goal of this study of pediatric meningiomas was to establish their epidemiological profile as well as their clinical and radiological features, to assess the long-term outcome, and compare this result with adult meningioma.
  • The most common clinical sign was raised intracranial pressure (90%).
  • The mean tumor diameter was 6.6 cm (range: 3 to 10 cm).
  • CONCLUSION: Pediatric meningiomas are larger than those found in the adult population; there is a male predominance with high incidence of a cystic component and high-grade meningiomas, thus explaining the increased recurrence rate despite the multimodal treatment.
  • [MeSH-major] Aging / pathology. Meningioma / pathology. Supratentorial Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20615516.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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52. Macfarlane RG, Galloway M, Plowman PN, Thomas DG: A highly vascular intracranial solitary fibrous tumor treated with radiotherapy and toremifene: case report. Neurosurgery; 2005 Jun;56(6):E1378; discussion E1378

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  • [Title] A highly vascular intracranial solitary fibrous tumor treated with radiotherapy and toremifene: case report.
  • OBJECTIVE AND IMPORTANCE: A case of an unusual intracranial solitary fibrous tumor with features of high vascularity and resultant difficulty at resection is presented.
  • INTERVENTION: At the time of the craniotomy, a highly vascular tumor was found.
  • Intraoperative hemorrhage limited resection to 20% of the tumor.
  • The histological diagnosis was of a solitary fibrous tumor with an unusually angiomatoid architecture.
  • A dramatic reduction in the size of the tumor was seen with no recurrence to date.
  • CONCLUSION: The use of surgery, radiotherapy, and toremifene in treatment of a vascular intracranial solitary fibrous tumor has been successful and warrants further research.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Neoplasms, Fibrous Tissue / therapy. Radiosurgery / methods. Toremifene / therapeutic use. Vascular Neoplasms / therapy
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Brain Neoplasms / therapy. Cell Adhesion Molecules / metabolism. Craniotomy / methods. Follow-Up Studies. Humans. Immunohistochemistry / methods. Magnetic Resonance Imaging / methods. Proto-Oncogene Proteins c-bcl-2 / metabolism. Treatment Outcome

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  • (PMID = 15918957.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antineoplastic Agents, Hormonal; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2; 7NFE54O27T / Toremifene
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53. Luther N, Edgar MA, Dunkel IJ, Souweidane MM: Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors. J Neurooncol; 2006 Aug;79(1):45-50
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  • [Title] Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors.
  • We retrospectively analyzed the results of eight patients who underwent endoscopic biopsy of a newly diagnosed primary intracranial germ cell tumor (GCT), and correlated tumor pathology with serum and cerebrospinal fluid (CSF) tumor markers and treatment outcome in order to determine the reliability of GCT sampling by this method.
  • A biopsy diagnosis was made in each patient, and the tumor histology correlated with tumor marker measurements for all six patients diagnosed with germinoma and for one with a yolk sac tumor.
  • One biopsy revealed only mature teratoma, an inconclusive result since the patient's serum and CSF tumor markers were elevated.
  • However, endoscopic biopsy may fail to yield an accurate diagnosis in cases of malignant non-germinomatous tumor.
  • We would thus conclude that when primary germ cell tumor is considered, endoscopic tumor biopsy is recommended in patients with a negative biochemical analysis, but not suggested for patients presenting with elevated tumor markers.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Neoplasms / pathology. Endoscopy. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Adolescent. Adult. Biopsy. Child. Child, Preschool. Chorionic Gonadotropin, beta Subunit, Human / blood. Chorionic Gonadotropin, beta Subunit, Human / cerebrospinal fluid. Diagnosis, Differential. Female. Germinoma / pathology. Humans. Magnetic Resonance Imaging. Male. Retrospective Studies. Teratoma / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 16598424.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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54. Ochalski PG, Edinger JT, Horowitz MB, Stetler WR, Murdoch GH, Kassam AB, Engh JA: Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage. J Neurosurg; 2010 May;112(5):978-82
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  • [Title] Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults.
  • The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis.
  • To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease).
  • This is the second report of primary intracranial AFH.
  • Additionally, hemorrhage from an intracranial AFH lesion has yet to be reported, and little is known about the radiographic characteristics and biological behavior of these lesions.
  • In this report, the authors describe the case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH.
  • Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Recurrence. Young Adult

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  • (PMID = 19731989.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Maiuri F, Gangemi M, Giamundo A, Mariniello G, Colella A, Vergara P, Del Basso De Caro ML: Intracranial extension of salivary gland tumors. Clin Neuropathol; 2010 Jan-Feb;29(1):9-13
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  • [Title] Intracranial extension of salivary gland tumors.
  • OBJECTIVE: The aim of this report is to describe 3 cases of salivary gland tumors with intracranial extension associated to an extracerebral mass lesion, and to discuss the frequence, pathology and treatment of these very rare localizations.
  • The location of the intradural extra-axial tumor was the middle fossa and temporal region in 2 cases and the cerebellopontine angle in 1.
  • RESULTS: 1 patient is alive and free of recurrence 32 months after removal of the intracranial tumor; 2 other patients died 28 months and 12 months postoperatively.
  • CONCLUSIONS: The intracranial extension of salivary gland tumors is a very rare event.
  • An aggressive surgical resection followed by radiotherapy is justified in cases with significant intracranial mass lesions and scarce bone and dural involvement.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Brain Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Brain / pathology. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome

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  • (PMID = 20040327.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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56. Novotný J Jr, Kollová A, Liscák R: Prediction of intracranial edema after radiosurgery of meningiomas. J Neurosurg; 2006 Dec;105 Suppl:120-6
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  • [Title] Prediction of intracranial edema after radiosurgery of meningiomas.
  • OBJECT: This study was focused on the development of models with which to predict the occurrence of intracranial edema after Gamma Knife surgery (GKS) of meningiomas, based on clinical and imaging data collected in a large group of patients.
  • The actuarial tumor control rate was 97.9% at 5 years.
  • Ten different factors were proposed as potential predictors for the occurrence of the intracranial edema after GKS: patient's sex, patient's age, previous surgery, edema before GKS treatment, lobulated margin of meningioma, heterogeneous appearance of the tumor, tumor volume, tumor location, maximum dose to the tumor, and dose to the tumor margin.
  • There was a significant difference in the incidence of edema for different patient age groups and a significantly higher incidence of edema occurrence in patients in whom no surgical procedure was performed before GKS, those with edema present before GKS, those with a tumor volume larger than 10 cm3, those in whom the tumor was located in the anterior fossa, those in whom the maximum dose to the tumor was higher than 30 Gy, and for different tumor margin doses.
  • A binary logistic regression multifactorial prediction model was used to identify the following significant factors to predict of edema occurrence after GKS: previous surgery, edema before the treatment, tumor volume, tumor location, and tumor margin dose.
  • [MeSH-major] Brain Edema / etiology. Meningeal Neoplasms / surgery. Meningioma / surgery. Radiosurgery / adverse effects
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies. Risk Factors. Young Adult

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  • (PMID = 18503344.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Zhang LW, Zhang MS, Qi J, Zhang JT, Li GL, Luo L, Wang ZC: Management of intracranial invasive olfactory neuroblastoma. Chin Med J (Engl); 2007 Feb 5;120(3):224-7
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  • [Title] Management of intracranial invasive olfactory neuroblastoma.
  • BACKGROUND: Olfactory neuroblastoma (ONB) is a rare tumor that often arise from the nasal cavity.
  • The aim of this study was to investigate the clinical characteristics and treatments of intracranial invasive ONB.
  • METHODS: Between July 2001 and August 2005, 5 patients with intracranial invasive ONB were treated in our department.
  • Intracranial ONB should be resected as far as possible, and treated by radiotherapy after the operation.
  • [MeSH-major] Brain Neoplasms / surgery. Esthesioneuroblastoma, Olfactory / surgery
  • [MeSH-minor] Adolescent. Adult. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17355826.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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58. Parsa AT, Wachhorst S, Lamborn KR, Prados MD, McDermott MW, Berger MS, Chang SM: Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults. J Neurosurg; 2005 Apr;102(4):622-8
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  • [Title] Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults.
  • OBJECT: The clinical outcome and treatment of adult patients with disseminated intracranial glioblastoma multiforme (GBM) is unclear.
  • The objective in the present study was to assess the prognostic significance of disseminated intracranial GBM in adults at presentation and at the time of tumor progression.
  • Patients with dissemination at first tumor progression (52 patients) overall had a shorter PPS than those in a control group with local progression, after adjusting for age, Kamofsky Performance Scale score, and time from tumor diagnosis to its progression (311 patients).
  • When analyzed according to tumor dissemination type, PPS was significantly shorter in patients with Type II (33 patients, p < 0.01) and Type III spread (11 patients, p < 0.01) but not in those with Type I spread (eight patients, p = 0.18).
  • CONCLUSIONS: Apparently, the presence of intracranial tumor dissemination on initial diagnosis does not in itself preclude aggressive treatment if a patient is otherwise well.
  • [MeSH-major] Brain Neoplasms / pathology. Glioblastoma / pathology. Neoplasm Staging
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 15871503.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA13525; United States / NCI NIH HHS / CA / CA82103; United States / NINDS NIH HHS / NS / NS42927
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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59. Schoenfeld GO, Amdur RJ, Schmalfuss IM, Morris CG, Keole SR, Mendenhall WM, Marcus RB Jr: Low-dose prophylactic craniospinal radiotherapy for intracranial germinoma. Int J Radiat Oncol Biol Phys; 2006 Jun 1;65(2):481-5
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  • [Title] Low-dose prophylactic craniospinal radiotherapy for intracranial germinoma.
  • PURPOSE: To report outcomes of patients with localized intracranial germinoma treated with low-dose craniospinal irradiation (CSI) followed by a boost to the ventricular system and primary site.
  • METHODS AND MATERIALS: Thirty-one patients had pathologically confirmed intracranial germinoma and no spine metastases.
  • Low-dose CSI was administered in 29 patients: usually 21 Gy of CSI, 9.0 Gy of ventricular boost, and a 19.5-Gy tumor boost, all at 1.5 Gy per fraction.
  • Our neuroradiologist recorded three-dimensional tumor size on magnetic resonance images before, during, and after radiotherapy.
  • In locally controlled patients, tumor response according to magnetic resonance scan was nearly complete within 6 months after radiotherapy.
  • CONCLUSIONS: Radiotherapy alone with low-dose prophylactic CSI cures almost all patients with localized intracranial germinoma.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Cranial Irradiation / methods. Germinoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Child. Diagnostic Errors. Female. Follow-Up Studies. Humans. Male. Radiotherapy Dosage. Teratoma / pathology. Teratoma / radiotherapy

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  • (PMID = 16530341.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Fountas KN, Kapsalaki E, Kassam M, Feltes CH, Dimopoulos VG, Robinson JS, Smith JR: Management of intracranial meningeal hemangiopericytomas: outcome and experience. Neurosurg Rev; 2006 Apr;29(2):145-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of intracranial meningeal hemangiopericytomas: outcome and experience.
  • Hemangiopericytomas represent rare intracranial tumors that have a tendency to recur locally and have the unique characteristic of giving extracranial metastases.
  • Preoperative embolization of the tumor was employed in 6/11 patients.
  • All patients underwent craniotomy for tumor resection and postoperative radiation treatment was employed on all but one.
  • Intracranial hemangiopericytomas management requires aggressive surgical resection, postoperative radiation treatment, and extensive follow-up to rule out local recurrences and delayed extracranial metastases.
  • [MeSH-major] Hemangiopericytoma / surgery. Meningeal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Diagnostic Imaging. Female. Follow-Up Studies. Glasgow Outcome Scale. Humans. Image Processing, Computer-Assisted. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Magnetic Resonance Spectroscopy. Male. Meninges / pathology. Meninges / surgery. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Postoperative Complications / diagnosis

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  • (PMID = 16391940.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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61. Onguru O, Kurt B, Gunhan O, Soylemezoglu F: Cyclooxygenase-2 (cox-2) expression and angiogenesis in intracranial ependymomas. Clin Neuropathol; 2006 Sep-Oct;25(5):216-20
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  • [Title] Cyclooxygenase-2 (cox-2) expression and angiogenesis in intracranial ependymomas.
  • AIM: Cyclooxygenase-2 (Cox-2), the inducible key enzyme in the biosynthesis of prostaglandins, appears to play a role in the regulation of progression, invasiveness and angiogenesis of various neoplasms including some glial tumors.
  • We studied Cox-2 expression, Ki-67 labeling index (Ki-67 LI) and microvessel density (MVD) in 30 intracranial ependymomas and analyzed the relationship among these parameters to evaluate their importance in the tumor biology of ependymomas.
  • [MeSH-major] Brain Neoplasms / blood supply. Brain Neoplasms / enzymology. Cyclooxygenase 2 / biosynthesis. Ependymoma / blood supply. Ependymoma / enzymology. Neovascularization, Pathologic
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Cell Proliferation. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Ki-67 Antigen / metabolism. Male

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  • (PMID = 17007443.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; EC 1.14.99.1 / Cyclooxygenase 2
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62. Leonetti JP, Anderson DE, Marzo SJ, Origitano TC, Shirazi M: Intracranial schwannomas of the lower cranial nerves. Otol Neurotol; 2006 Dec;27(8):1142-5
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  • [Title] Intracranial schwannomas of the lower cranial nerves.
  • PATIENTS: All patients with intracranial lower cranial nerve schwannomas treated surgically in our institution between July 1998 and July 2005.
  • INTERVENTION: A retrosigmoid, transcondylar, or combined approach was used for tumor recurrence.
  • RESULTS: Thirty-nine patients underwent surgical resection, with complete tumor removal in 32, near-total resection in 5 patients, and subtotal tumor excision in 2 patients.
  • Long-term (mean, 8.2 years) magnetic resonance imaging surveillance demonstrated recurrent tumor in 2 of 32 complete resections and slow regrowth in 2 of 7 patients with known residual disease.
  • DISCUSSION: Intracranial schwannomas of the lower cranial nerves are relatively uncommon and may present with subtle or no clinical symptoms.
  • Successful surgical resection with low risk of tumor recurrence can be achieved with the retrosigmoid or transcondylar approach.
  • [MeSH-major] Cranial Fossa, Posterior. Cranial Nerve Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Neurilemmoma / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cerebral Angiography. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Otorhinolaryngologic Surgical Procedures. Reoperation. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17130803.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Preusser M, Wolfsberger S, Czech T, Slavc I, Budka H, Hainfellner JA: Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome. Am J Clin Pathol; 2005 Oct;124(4):543-9
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  • [Title] Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome.
  • Survivin expression has been described as prognostic factor in various tumor types and has been shown to correlate with cytologic anaplasia in ependymoma.
  • We immunohistochemically studied survivin expression and its association with Ki-67 and topoisomerase IIalpha (TIIalpha) expression and outcome in 63 patients with intracranial ependymoma.
  • Survivin is expressed in a fraction of nuclei of tumor and endothelial cells including mitotic figures.
  • On average, 62.86% of Ki-67-expressing tumor cell nuclei coexpress survivin, whereas 92.2% of survivin-expressing nuclei coexpress Ki-67.
  • [MeSH-major] Brain Neoplasms / metabolism. Cell Proliferation. Cysteine Proteinase Inhibitors / metabolism. Ependymoma / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Neoplasm / metabolism. Austria / epidemiology. Biomarkers, Tumor. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cohort Studies. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Humans. Infant. Inhibitor of Apoptosis Proteins. Ki-67 Antigen / metabolism. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 16146813.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Cysteine Proteinase Inhibitors; 0 / DNA-Binding Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Ki-67 Antigen; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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64. Ziadi A, Saliba I: Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review. Auris Nasus Larynx; 2010 Oct;37(5):539-45
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  • [Title] Malignant peripheral nerve sheath tumor of intracranial nerve: a case series review.
  • OBJECTIVES: The incidence of malignant peripheral nerve sheath tumor (MPNST) is approximately 0.001%.
  • Those involving intracranial nerves are even more exceptional.
  • (1) to review all cases of intracranial MPNST described in the literature, (2) to highlight the suspicion of intracranial MPNST, (3) to identify the gross pathology, the histopathology, the immunohistochemistry, (4) to discuss the differential diagnosis, the treatment, the recurrence rate, the follow-up, the incidence of metastasis and the prognosis.
  • We used the following Keywords: "malignant peripheral nerve sheath tumor", "cranial nerve", "neurosarcoma", "malignant schwannoma", "neurofibroma", "malignant neurofibroma" and "nerve tumor".
  • We considered cases where MPNST involved an intracranial cranial nerve.
  • 13 cases were treated with radiotherapy for tumor recurrence and metastasis.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Nerve Sheath Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Transformation, Neoplastic / pathology. Child. Child, Preschool. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / radiotherapy. Neurilemmoma / surgery. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / radiotherapy. Neurofibroma / surgery. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / pathology. Neurofibromatosis 1 / radiotherapy. Neurofibromatosis 1 / surgery. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / radiotherapy. Neurofibromatosis 2 / surgery. Radiotherapy, Adjuvant. Spinal Neoplasms / mortality. Spinal Neoplasms / pathology. Spinal Neoplasms / secondary. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20399579.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
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65. Fichten A, Bourgeois P, Desaulty A, Louis E, Lejeune JP: [Intracranial facial nerve schwannomas. Seven cases reviewed]. Neurochirurgie; 2006 Feb;52(1):37-46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intracranial facial nerve schwannomas. Seven cases reviewed].
  • BACKGROUND AND PURPOSE: Intracranial facial nerve schwannomas are rare neoplasms.
  • Preoperative diagnosis is difficult because of non-specific clinical presentations (deafness, facial paralysis sudden or progressive) and radiological differential diagnosis (petrous bone tumor, vestibular schwannoma).
  • METHODS: Seven cases (four men and three women) of intracranial facial nerve schwannomas were retrospectively studied.
  • A large tumor requires surgery, but surveillance can be a good option for a small one, considering the risk of postoperative facial palsy.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Facial Nerve Diseases / surgery. Neurilemmoma / surgery
  • [MeSH-minor] Adult. Aged. Audiometry, Pure-Tone. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Deafness / etiology. Deafness / surgery. Ear, Inner / pathology. Ear, Inner / surgery. Facial Paralysis / etiology. Facial Paralysis / surgery. Female. Humans. Male. Middle Aged. Neurologic Examination. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Postoperative Complications / surgery. Reoperation. Retrospective Studies

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  • (PMID = 16609658.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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66. Johnson MD, Moots PL, Zhuang Z, Weil RJ: Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia. Ann Clin Lab Sci; 2009;39(3):295-302
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  • [Title] Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia.
  • We report a case of a primitive neuroectodermal tumor (PNET) arising in the cerebellum and pons 7 yr after intracranial radiation and chemotherapy for leukemia involving the CNS.
  • [MeSH-minor] Adult. Bone Marrow Transplantation. Brain / pathology. Chromosomes, Human, Pair 10 / genetics. Chromosomes, Human, Pair 17 / genetics. Humans. Loss of Heterozygosity / genetics. Magnetic Resonance Imaging. Male. Methotrexate / administration & dosage. Methotrexate / therapeutic use. PTEN Phosphohydrolase / genetics. Proto-Oncogene Proteins c-ret / genetics. Tumor Suppressor Protein p53 / genetics. Whole-Body Irradiation

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  • (PMID = 19667415.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase; YL5FZ2Y5U1 / Methotrexate
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67. Gursoy A, Cesur M, Aktaş B, Utkan G, Gedik VT, Erdogan M, Kamel N: Intracranial aggressive fibromatosis presenting as panhypopituitarism and diabetes insipidus. Pituitary; 2005;8(2):123-6
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  • [Title] Intracranial aggressive fibromatosis presenting as panhypopituitarism and diabetes insipidus.
  • Intracranial AF is extremely rare and requires aggressive treatment to prevent recurrence.
  • We present a case of a 34 year-old male with AF involving intracranial structures causing panhypopituitarism and diabetes insipidus.
  • The tumor was markedly isointense on both T2- and T1-weighted images relative to gray matter, and enhanced strongly after administration of gadolinium.
  • On the basis of reports that radiotherapy is an effective treatment for this kind of tumor, we administered radiation to the affected area, since chemotherapy and hormonal treatment of non-resectable tumors are not satisfactory.
  • [MeSH-major] Diabetes Insipidus / diagnosis. Fibromatosis, Aggressive / diagnosis. Hypopituitarism / diagnosis. Skull Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male


68. Arsene D, Georgescu A, Dănăilă L, Ardeleanu C: Giant intracranial endolymphatic sac tumor (ELST). Case presentation and histogenetic considerations. Rom J Morphol Embryol; 2008;49(1):85-90

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  • [Title] Giant intracranial endolymphatic sac tumor (ELST). Case presentation and histogenetic considerations.
  • We present a giant tumor of the skull base compressing the brain in a 40-years-old man.
  • The tumor was policystic at imaging.
  • Its histopathology, immunohistochemical profile and long evolution suggest an endolymphatic sac tumor (ELST), a rare case of neoplasia.
  • This could be from either the organ of Corti or some local cells that generate a resemblance with a systemic tumor, the so-called benign mesothelioma.
  • [MeSH-major] Endolymphatic Sac / metabolism. Endolymphatic Sac / pathology. Meningioma / metabolism. Meningioma / pathology. Skull Base Neoplasms / metabolism. Skull Base Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Humans. Male. Tumor Burden

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  • (PMID = 18273509.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Sumrall A, Fredericks R, Berthold A, Shumaker G: Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease. J Neurooncol; 2010 Apr;97(2):275-7
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  • [Title] Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease.
  • Epithelioid Hemangioendothelioma (EH) is a rare soft-tissue tumor which may present as an isolated tumor or can spread to affect internal organs.
  • This case report describes a young woman who developed cutaneous EH with concurrent intracranial disease during pregnancy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Hemangioendothelioma, Epithelioid / drug therapy. Thalidomide / analogs & derivatives
  • [MeSH-minor] Adult. Clinical Trials as Topic. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 19898746.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 4Z8R6ORS6L / Thalidomide; F0P408N6V4 / lenalidomide
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70. Luo W, Li YH, Yang JJ, Tian J, Xu JG: Cerebrospinal fluid and plasma propofol concentration during total intravenous anaesthesia of patients undergoing elective intracranial tumor removal. J Zhejiang Univ Sci B; 2005 Sep;6(9):865-8
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  • [Title] Cerebrospinal fluid and plasma propofol concentration during total intravenous anaesthesia of patients undergoing elective intracranial tumor removal.
  • OBJECTIVE: The aim of this paper is to compare the propofol concentration in plasma and cerebrospinal fluid (CSF) in patients scheduled for intracranial tumor removal and anaesthetized using propofol as part of a total intravenous anaesthesia technique.
  • METHODS: Twenty-seven patients (ASA I-II) scheduled for elective intracranial tumor removal were studied.
  • Discrepancies may result from high plasma protein binding of propofol, intracranial pathology and sampling volume.
  • [MeSH-major] Anesthetics, Intravenous / blood. Anesthetics, Intravenous / cerebrospinal fluid. Brain Neoplasms / surgery. Propofol / blood. Propofol / cerebrospinal fluid
  • [MeSH-minor] Adolescent. Adult. Aged. Anesthesia, Intravenous. Blood Proteins / metabolism. Elective Surgical Procedures. Female. Humans. Male. Middle Aged. Protein Binding

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  • (PMID = 16130186.001).
  • [ISSN] 1673-1581
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; 0 / Blood Proteins; YI7VU623SF / Propofol
  • [Other-IDs] NLM/ PMC1389902
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71. Jabbour SK, Zhang Z, Arnold D, Wharam MD: Risk of second tumor in intracranial germinoma patients treated with radiation therapy: the Johns Hopkins experience. J Neurooncol; 2009 Jan;91(2):227-32
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  • [Title] Risk of second tumor in intracranial germinoma patients treated with radiation therapy: the Johns Hopkins experience.
  • BACKGROUND: We reviewed the risk of second tumor (ST), both malignant and benign, in germinoma survivors followed at the Johns Hopkins Hospital (JHH).
  • METHODS: Between 1977 and 2002, 27 patients with intracranial germinoma were treated with radiation therapy (RT).
  • [MeSH-major] Neoplasms, Radiation-Induced / epidemiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / epidemiology. Neoplasms, Second Primary / etiology. Radiotherapy / adverse effects. Risk
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / radiotherapy. Child. Combined Modality Therapy. Female. Follow-Up Studies. Germinoma / radiotherapy. Humans. Incidence. Male. Retrospective Studies. Risk Assessment. Time Factors. Treatment Outcome

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  • (PMID = 18813873.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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72. Kano H, Niranjan A, Mongia S, Kondziolka D, Flickinger JC, Lunsford LD: The role of stereotactic radiosurgery for intracranial hemangioblastomas. Neurosurgery; 2008 Sep;63(3):443-50; discussion 450-1
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  • [Title] The role of stereotactic radiosurgery for intracranial hemangioblastomas.
  • OBJECTIVE: To evaluate the role of stereotactic radiosurgery (SRS) in the management of recurrent or residual intracranial hemangioblastomas, we assessed tumor control, survival, and complications in 32 consecutive patients.
  • METHODS: We retrospectively reviewed records of 32 consecutive hemangioblastoma patients (74 intracranial tumors) who underwent gamma knife SRS.
  • Follow-up imaging studies demonstrated tumor control in 68 tumors (91.9%).
  • Factors associated with an improved progression-free survival included von Hippel-Lindau disease-associated hemangioblastoma, solid tumor, lower tumor volume, and greater marginal dose.
  • CONCLUSION: SRS is an important tool in the management of hemangioblastomas and is associated with a high tumor control rate and a low risk of adverse radiation effects.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Radiosurgery / trends
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate / trends. Young Adult

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  • (PMID = 18812955.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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73. Gurkanlar D, Er U, Sanli M, Ozkan M, Sekerci Z: Peritumoral brain edema in intracranial meningiomas. J Clin Neurosci; 2005 Sep;12(7):750-3
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  • [Title] Peritumoral brain edema in intracranial meningiomas.
  • PATIENTS AND METHODS: In a series of 55 patients with intracranial meningiomas, factors possibly related to the development of PTBE were analyzed.
  • EI was calculated by dividing the area of PTBE by that of the tumor.
  • [MeSH-major] Brain Edema / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Age Factors. Aged. Factor Analysis, Statistical. Female. Humans. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Sex Factors

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  • (PMID = 16165364.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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74. Osuka S, Tsuboi K, Takano S, Ishikawa E, Matsushita A, Tokuuye K, Akine Y, Matsumura A: Long-term outcome of patients with intracranial germinoma. J Neurooncol; 2007 May;83(1):71-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcome of patients with intracranial germinoma.
  • PURPOSE: This study was to clarify the long-term subjective functional state and the therapeutic factors that may influence the outcome and ADL of patients with intracranial germinoma.
  • Recurrence occurred in 5 patients, and 1 patient died of tumor.
  • Radiotherapy administered to the field encompassing the whole ventricle was essential for long-term tumor control.
  • [MeSH-major] Basal Ganglia. Brain Neoplasms / therapy. Germinoma / therapy. Pineal Gland. Pituitary Gland, Posterior
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Female. Humans. Incidence. Karnofsky Performance Status. Longitudinal Studies. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / mortality. Neurosurgical Procedures. Surveys and Questionnaires. Survival Analysis. Treatment Outcome

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  • (PMID = 17245622.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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75. Rosburg T, Trautner P, Elger CE, Kurthen M: Attention effects on sensory gating--intracranial and scalp recordings. Neuroimage; 2009 Nov 15;48(3):554-63

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Attention effects on sensory gating--intracranial and scalp recordings.
  • In the current study, the impact of attention on sensory gating was studied by scalp and intracranial recordings.
  • The study sample consisted of epilepsy and tumor patients undergoing presurgical evaluation by means of implanted electrodes.
  • [MeSH-minor] Acoustic Stimulation. Adolescent. Adult. Aged. Brain Neoplasms / physiopathology. Brain Neoplasms / surgery. Electrodes, Implanted. Electroencephalography. Epilepsy / physiopathology. Epilepsy / surgery. Evoked Potentials. Female. Humans. Male. Middle Aged. Neuropsychological Tests. Scalp. Time Factors. Young Adult

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  • (PMID = 19576991.001).
  • [ISSN] 1095-9572
  • [Journal-full-title] NeuroImage
  • [ISO-abbreviation] Neuroimage
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Kim JW, Kim DG, Chung HT, Paek SH, Kim YH, Han JH, Park CK, Kim CY, Jung HW: Gamma Knife stereotactic radiosurgery for intracranial hemangiopericytomas. J Neurooncol; 2010 Aug;99(1):115-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma Knife stereotactic radiosurgery for intracranial hemangiopericytomas.
  • The purpose of this study is to determine the efficacy of Gamma Knife stereotactic radiosurgery (GK SRS) for intracranial hemangiopericytomas, and to investigate the optimal dose for successful tumor control without adverse effects.
  • The mean tumor volume was 2.2 cm(3) (range 0.2-9.9 cm(3)), and the mean and median marginal doses were 18.1 and 20 Gy (range 11-22 Gy), respectively, at the 50% isodose line.
  • Successful tumor control was achieved in 14 of 17 lesions (82.4%) at time of last follow-up after GK SRS.
  • Actuarial local tumor control rates at 1, 2, and 5 years after GK SRS were 100%, 84.6%, and 67.7%, respectively.
  • Marginal dose (>or=17 Gy) was the only statistically significant factor for local tumor control on univariate analysis.
  • Our results suggest that doses higher than previously used (around 15 Gy) are desirable to achieve better local tumor control of hemangiopericytomas.
  • [MeSH-major] Brain Neoplasms / surgery. Hemangiopericytoma / surgery. Radiosurgery / methods
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Retrospective Studies. Statistics, Nonparametric

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  • (PMID = 20084426.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Kida Y, Yoshimoto M, Hasegawa T: Radiosurgery for intracranial gliomas. Prog Neurol Surg; 2009;22:122-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for intracranial gliomas.
  • Likewise, the tumor control rates were very high for GI and GII tumors, and were very low for GIII and GIV tumors.
  • These results suggest differences in tumor infiltration and malignant activity at the periphery, and indicate the high efficacy of radiosurgery as well as its limitations.
  • [MeSH-major] Astrocytoma / mortality. Astrocytoma / surgery. Brain Neoplasms / mortality. Brain Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Disease-Free Survival. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Survival Analysis. Young Adult

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  • (PMID = 18948724.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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78. Chamberlain MC, Johnston SK: Temozolomide for recurrent intracranial supratentorial platinum-refractory ependymoma. Cancer; 2009 Oct 15;115(20):4775-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temozolomide for recurrent intracranial supratentorial platinum-refractory ependymoma.
  • Time to tumor progression ranged from 1 to 7 months (median, 2 months).
  • CONCLUSIONS: TMZ in this dose schedule demonstrated little efficacy in a cohort of adults with recurrent, intracranial, platinum-refractory ependymoma.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Dacarbazine / analogs & derivatives. Ependymoma / drug therapy. Supratentorial Neoplasms / drug therapy
  • [MeSH-minor] Adult. Carboplatin / therapeutic use. Cisplatin / therapeutic use. Disease-Free Survival. Drug Resistance, Neoplasm. Female. Ferrous Compounds. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retreatment

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  • [Copyright] Copyright (c) 2009 American Cancer Society.
  • (PMID = 19569246.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Ferrous Compounds; 33269-57-7 / EX 10-478; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin
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79. Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ, Lin JW, Chute DJ, Mischel PS, Cloughesy TF, Roth MD: Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clin Cancer Res; 2005 Aug 1;11(15):5515-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment.
  • PURPOSE: We previously reported that autologous dendritic cells pulsed with acid-eluted tumor peptides can stimulate T cell-mediated antitumor immune responses against brain tumors in animal models.
  • As a next step in vaccine development, a phase I clinical trial was established to evaluate this strategy for its feasibility, safety, and induction of systemic and intracranial T-cell responses in patients with glioblastoma multiforme.
  • EXPERIMENTAL DESIGN: Twelve patients were enrolled into a multicohort dose-escalation study and treated with 1, 5, or 10 million autologous dendritic cells pulsed with constant amounts (100 mug per injection) of acid-eluted autologous tumor peptides.
  • CONCLUSIONS: Together, our results suggest that the absence of bulky, actively progressing tumor, coupled with low TGF-beta(2) expression, may identify a subgroup of glioma patients to target as potential responders in future clinical investigations of dendritic cell-based vaccines.
  • [MeSH-major] Cancer Vaccines / metabolism. Central Nervous System / metabolism. Central Nervous System Neoplasms / pathology. Central Nervous System Neoplasms / therapy. Dendritic Cells / cytology. T-Lymphocytes / metabolism
  • [MeSH-minor] Adult. Aged. Cohort Studies. Dose-Response Relationship, Drug. Female. Humans. Immunohistochemistry. Male. Middle Aged. Peptides / chemistry. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. T-Lymphocytes, Cytotoxic / immunology. Time Factors. Transforming Growth Factor beta / metabolism. Transforming Growth Factor beta2. Treatment Outcome

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  • (PMID = 16061868.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA82666; United States / NCI NIH HHS / CA / CA91545; United States / NCRR NIH HHS / RR / M01-RR00865; United States / NCI NIH HHS / CA / T32-CA009120
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / Peptides; 0 / RNA, Messenger; 0 / TGFB2 protein, human; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2
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80. Girard F, Moumdjian R, Boudreault D, Chouinard P, Bouthilier A, Ruel M: The effect of sedation on intracranial pressure in patients with an intracranial space-occupying lesion: remifentanil versus propofol. Anesth Analg; 2009 Jul;109(1):194-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of sedation on intracranial pressure in patients with an intracranial space-occupying lesion: remifentanil versus propofol.
  • BACKGROUND: In this study, we compared the effect of light sedation with remifentanil versus propofol on intracranial (ICP) and cerebral perfusion pressure (CPP) of patients undergoing stereotactic brain tumor biopsy under regional anesthesia.
  • Forty patients undergoing stereotactic brain tumor biopsy under regional anesthesia were randomized into two groups to receive remifentanil or propofol titrated to a level of four on the modified Assessment of Alertness/Sedation Scale.
  • CONCLUSION: Light sedation with remifentanil does not result in a higher ICP than propofol in patients undergoing stereotactic brain tumor biopsy.
  • [MeSH-major] Hypnotics and Sedatives / pharmacology. Intracranial Pressure / drug effects. Piperidines / pharmacology. Propofol / pharmacology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Prospective Studies. Wakefulness / drug effects. Wakefulness / physiology

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  • (PMID = 19535710.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives; 0 / Piperidines; P10582JYYK / remifentanil; YI7VU623SF / Propofol
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81. Kang SG, Yoo DS, Cho KS, Kim DS, Chang ED, Huh PW, Kim MC: Coexisting intracranial meningeal melanocytoma, dermoid tumor, and Dandy-Walker cyst in a patient with neurocutaneous melanosis. Case report. J Neurosurg; 2006 Mar;104(3):444-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexisting intracranial meningeal melanocytoma, dermoid tumor, and Dandy-Walker cyst in a patient with neurocutaneous melanosis. Case report.
  • Primary intracranial melanocytic and dermoid tumors are also benign congenital lesions that usually arise from the leptomeninges and are formed by the inclusion of cutaneous ectoderm at the time of neural tube closure.
  • The authors describe a patient with coexisting intracranial meningeal melanocytoma, NCM with Dandy-Walker malformation, and intraventricular dermoid tumor.
  • [MeSH-major] Dandy-Walker Syndrome / complications. Dermoid Cyst / pathology. Melanoma / pathology. Melanosis / complications. Meningeal Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Comorbidity. Humans. Male

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  • (PMID = 16572661.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Lynch JC, Emmerich JC, Kislanov S, Gouvêa F, Câmara L, Santos Silva SM, D'Ippolito MM: [Brain tumors and pregnancy]. Arq Neuropsiquiatr; 2007 Dec;65(4B):1211-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Tumor cerebral e gravidez.
  • AIM: To identify the best medical procedure to be followed for a pregnant patient harboring a brain tumor.
  • It seems that pregnancy aggravates the clinical course of intracranial tumors.
  • CONCLUSION: The best moment to recommend the craniotomy and the neurosurgical removal of the tumor will depend of the mothers neurological condition, the tumor histological type as well as the gestational age.
  • [MeSH-major] Brain Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Craniotomy. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Retrospective Studies

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  • (PMID = 18345432.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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83. Seyednejad F, Tubbs RS, Shoja MM, Daghigi MH, Oakes WJ: Presumed recurrence of intracranial Rosai-Dorfman disease as a cervical spine tumor. Acta Neurochir (Wien); 2007;149(4):425-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presumed recurrence of intracranial Rosai-Dorfman disease as a cervical spine tumor.
  • We report a patient who developed presumed secondary symptomatic involvement of the spine five years following therapy for a primary intracranial RDD.
  • [MeSH-major] Cervical Vertebrae / pathology. Cranial Fossa, Posterior / pathology. Histiocytosis, Sinus / pathology. Spinal Cord Neoplasms / pathology. Spinal Diseases / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Prednisolone / therapeutic use. Radiotherapy. Subarachnoid Space / pathology. Subarachnoid Space / physiopathology. Subdural Space / pathology. Subdural Space / physiopathology. Treatment Outcome


84. Huang QH, Yang K, Cai X, Wang ZZ, Ma CY, Shun BY, Chen ZG: [Endovascular embolization and microsurgical operation treatment of intracranial anterior circulation aneurysms]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Nov;33(11):1050-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endovascular embolization and microsurgical operation treatment of intracranial anterior circulation aneurysms].
  • OBJECTIVE: To explore the surgical treatment and effect of intracranial anterior circulation aneurysms.
  • METHODS: Thirty-eight patients with intracranial anterior circulation aneurysms were enrolled, 9 were treated with endovascular embolization,and 29 with pterion approach micro-euthyphoria operation.
  • CONCLUSION: Surgical treatment of intracranial anterior circulation aneurysms is the first choice to help blood tumor cleaning-up and intracranial pressure degrading.
  • [MeSH-major] Embolization, Therapeutic / methods. Intracranial Aneurysm / surgery. Microsurgery / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19060375.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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85. Nishioka H, Haraoka J, Miki T: Management of intracranial germ cell tumors presenting with rapid deterioration of consciousness. Minim Invasive Neurosurg; 2006 Apr;49(2):116-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of intracranial germ cell tumors presenting with rapid deterioration of consciousness.
  • OBJECTIVES: The value of surgical intervention in the management of intracranial germ cell tumors remains controversial.
  • PATIENTS: We report three patients who presented with rapid deterioration of consciousness but resulted in complete remission of the tumor after emergency surgery for both diagnostic (biopsy) and therapeutic (for hydrocephalus) purposes followed by prompt initiation of radiochemotherapy.
  • Thus, emergency surgery with a less invasive procedure is the first choice of treatment, i. e., endoscopic surgery for pineal region tumor and CT-guided biopsy for basal ganglia tumor.
  • [MeSH-major] Brain Neoplasms / surgery. Consciousness Disorders / etiology. Endodermal Sinus Tumor / surgery. Germinoma / surgery. Seminoma / surgery
  • [MeSH-minor] Adult. Child. Humans. Male. Testicular Neoplasms / pathology. Time Factors

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  • (PMID = 16708342.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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86. Utsuki S, Oka H, Tanizaki Y, Kondo K, Kawano N, Fujii K: Pathological features of intracranial germinomas with reference to fibrous tissue and granulomatous change. Brain Tumor Pathol; 2005;22(1):9-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological features of intracranial germinomas with reference to fibrous tissue and granulomatous change.
  • Intracranial germinomas are accompanied occasionally by a significant granulomatous change and abundant fibrous tissue, and this has made their pathological diagnosis difficult.
  • However, the incidence of the granulomatous reaction and the presence of fibrous tissue together with their clinical characteristics in intracranial germinomas have not been fully investigated.
  • The location of the tumor was the pineal region (5 cases), the suprasellar region (13 cases), multiple lesions (2 cases), the basal ganglia region (1 case), and other regions (3 cases).
  • Thus, the fibroinflammatory type B accounted for 25% of the intracranial germinomas.
  • [MeSH-major] Brain Neoplasms / pathology. Germinoma / pathology. Granuloma / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Young Adult

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  • (PMID = 18095098.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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87. Barami K: CyberKnife radiosurgery for management of intracranial perineural spread of cutaneous malignancies. J Clin Neurosci; 2010 Oct;17(10):1322-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CyberKnife radiosurgery for management of intracranial perineural spread of cutaneous malignancies.
  • Intracranial perineural spread (PNS) is a rare complication of cutaneous malignancies and refers to access of the tumor to the intracranial space typically by tracking along cranial nerves.
  • Radiographic workup showed recurrent tumor involving multiple cranial nerves.
  • To the author's knowledge, these are the first reported patients with intracranial PNS treated via CyberKnife radiosurgery.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Cranial Nerves / pathology. Radiosurgery. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Humans. Magnetic Resonance Imaging / methods. Male. Neoplasm Invasiveness

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20594857.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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88. Porter A, Lyons MK, Wingerchuk DM, Bosch EP: Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. Clin Neurol Neurosurg; 2006 Dec;108(8):787-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension.
  • Increased intracranial pressure is rarely seen in association with spinal tumors.
  • We describe a young, non-obese man who presented with increased intracranial pressure, papilledema and visual obscuration.
  • Multiple cerebrospinal fluid (CSF) examinations with normal or minimally elevated CSF protein lead to the initial diagnosis of idiopathic intracranial hypertension.
  • The spinal MRI showed a low cervical-upper thoracic intramedullary tumor.
  • The suspected mechanisms of spinal tumors causing increased intracranial pressure are reviewed as well as three other cases of spinal astrocytomas previously reported in the literature that presented with papilledema and increased intracranial pressure without hydrocephalus.
  • This case illustrates that increased intracranial pressure may in exceptional cases of spinal tumors precede the more typical myelopathic presentation by months and mimic idiopathic intracranial hypertension.
  • [MeSH-major] Astrocytoma / diagnosis. Pseudotumor Cerebri / etiology. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Disease Progression. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neurologic Examination. Papilledema / etiology. Spinal Cord / pathology. Tomography, X-Ray Computed. Vision Disorders / etiology

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  • (PMID = 16298472.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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89. Huang X, Zhang R, Zhou LF: Diagnosis and treatment of intracranial immature teratoma. Pediatr Neurosurg; 2009;45(5):354-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and treatment of intracranial immature teratoma.
  • OBJECTIVE: The purpose of this paper is toexplore the clinical features, treatment and prognosis of intracranial immature teratomas.
  • METHODS: The clinical data, serum levels of tumor markers, treatment regimens and prognosis of 15 patients with intracranial immature teratomas were reviewed retrospectively.
  • The tumor was totally removed in 12 cases, subtotally in 2, and partially in 1 case.
  • CONCLUSIONS: The prognosis of intracranial immature teratomas is poor.
  • The detection of their clinical manifestation, the analysis of imaging features and the serum levels of tumor markers are helpful in diagnosing intracranial teratomas.
  • The total removal of the tumor is important to cure the disease.
  • If a patient has residual or recurrent tumor after surgery, gamma knife surgery can be effective.
  • [MeSH-major] Brain Neoplasms. Magnetic Resonance Imaging. Radiosurgery. Teratoma
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / blood. Child. Chorionic Gonadotropin, beta Subunit, Human / blood. Female. Follow-Up Studies. Humans. Male. Prognosis. Retrospective Studies. Survival Rate. Third Ventricle / pathology. Young Adult. alpha-Fetoproteins / metabolism

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19907199.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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90. Schrödter S, Hakenberg O, Oehlschläger S, Fröhner M, Kittner T, Wirth M: [Acute abdominal pain due to a ventriculo-peritoneal shunt metastasis of an intracranial germ cell tumor]. Aktuelle Urol; 2006 Mar;37(2):141-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acute abdominal pain due to a ventriculo-peritoneal shunt metastasis of an intracranial germ cell tumor].
  • CASE REPORT: The case of a metastasis of a primary intracranial germ cell tumor via a temporary-ventriculo-peritoneal shunt as a cause of acute abdominal pain is reported.
  • The germ cell tumor markers were useful in establishing the diagnosis.
  • [MeSH-major] Abdomen, Acute / etiology. Colic / etiology. Hydrocephalus / surgery. Kidney Diseases / etiology. Neoplasm Seeding. Pelvic Neoplasms / secondary. Pinealoma / diagnosis. Pinealoma / secondary. Ventriculoperitoneal Shunt / instrumentation
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Hydronephrosis / diagnosis. Hydronephrosis / etiology. Magnetic Resonance Imaging. Male. Reoperation. Ureteral Obstruction / diagnosis. Ureteral Obstruction / etiology

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  • (PMID = 16625472.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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91. Prabhu K, Daniel RT, Mani S, Chacko AG: Dermoid tumor with diastematobulbia. Surg Neurol; 2009 Dec;72(6):717-21; discussion 721

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoid tumor with diastematobulbia.
  • BACKGROUND: Dermoid tumors are rare congenital lesions and account for 0.2% to 1.8% of all intracranial tumors.
  • Dermoid tumor with diastematobulbia is very rare.
  • CASE DESCRIPTION: We report a dermoid tumor in an adult female with an unusual location and morphology.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Cerebral Ventricle Neoplasms / surgery. Cisterna Magna / surgery. Dermoid Cyst / surgery. Fourth Ventricle / surgery. Medulla Oblongata / surgery. Neoplasms, Multiple Primary / surgery. Pons / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neural Tube Defects / diagnosis. Neural Tube Defects / pathology. Neural Tube Defects / surgery. Neurologic Examination. Postoperative Complications / diagnosis

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608253.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Simon SL, Moonis G, Judkins AR, Scobie J, Burnett MG, Riina HA, Judy KD: Intracranial capillary hemangioma: case report and review of the literature. Surg Neurol; 2005 Aug;64(2):154-9
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  • [Title] Intracranial capillary hemangioma: case report and review of the literature.
  • The authors present an exceedingly rare case of an intracranial capillary hemangioma arising in an adult.
  • The patient underwent a resection of her tumor, which was diagnosed as a capillary hemangioma by histopathologic examination.
  • The patient required 2 further resections after the lesion exhibited a rapid regrowth from residual tumor in the left transverse sinus.
  • CONCLUSIONS: Intracranial capillary hemangiomas are exceedingly rare entities, with a capability for rapid growth.
  • [MeSH-major] Brain Neoplasms / surgery. Hemangioma, Capillary / surgery. Neoplasm Recurrence, Local / surgery. Pregnancy Complications, Neoplastic / surgery
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Treatment Outcome

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  • (PMID = 16051010.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Kim IY, Jung S, Jung TY, Kang SS, Kim TS: Traumatic rupture of an intracranial dermoid cyst. J Clin Neurosci; 2008 Apr;15(4):469-71
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  • [Title] Traumatic rupture of an intracranial dermoid cyst.
  • This paper reports the first case in which an intracranial dermoid cyst that underwent traumatic rupture was treated surgically and discusses the importance of the preoperative radiological identification and management of the rupture.
  • For adequate management of a ruptured intracranial dermoid cyst, in addition to early surgery, we emphasize the importance of expeditious identification of the rupture with MRI, including an additional fat-suppression sequence, and prompt management of the accompanying chemical meningitis with intravenous steroid therapy beginning from the pre-operative period.
  • [MeSH-major] Brain Neoplasms / complications. Dermoid Cyst / complications. Rupture, Spontaneous / complications
  • [MeSH-minor] Adult. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 18258431.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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94. Baussart B, Lepeintre JF, Condette-Auliac S, Dupuy M, Gaillard S: [Primitive intracranial trigeminal nerve germinoma. Case report]. Neurochirurgie; 2007 Feb;53(1):43-6
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  • [Title] [Primitive intracranial trigeminal nerve germinoma. Case report].
  • On the basis of histological analysis and negativity of tumor marker levels in serum and cerebrospinal fluid (alpha-fetoprotein alpha, human beta-chorionic gonadotropin), a primitive non-secreting intracranial germinoma was diagnosed.
  • Under combined chemotherapy (carboplatine, ifosfamide, etoposide) followed by focal fractionated radiotherapy delivering 40 Gy to the initial tumor volume, the outcome was excellent.
  • Primitive intracranial germinomas are rare malignant tumors involving mainly pineal and hypothalamic regions.
  • We report a case of intracranial trigeminal nerve germinoma.
  • [MeSH-major] Cranial Nerve Neoplasms / therapy. Germinoma / therapy. Trigeminal Nerve Diseases / therapy
  • [MeSH-minor] Adult. Cavernous Sinus / pathology. Combined Modality Therapy. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neurologic Examination. Paresthesia / etiology

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  • (PMID = 17337016.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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95. Nagar VA, Ye J, Xu M, Ng WH, Yeo TT, Ong PL, Lim CC: Multivoxel MR spectroscopic imaging--distinguishing intracranial tumours from non-neoplastic disease. Ann Acad Med Singapore; 2007 May;36(5):309-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multivoxel MR spectroscopic imaging--distinguishing intracranial tumours from non-neoplastic disease.
  • INTRODUCTION: Multi-voxel MR spectroscopic imaging (MRSI) provides chemical metabolite information that can supplement conventional MR imaging in the study of intracranial neoplasia.
  • Our purpose was to use a robust semi-automated spectroscopic analysis to distinguish intracranial tumours from non-neoplastic disease.
  • MATERIALS AND METHODS: Twenty intracranial tumours and 15 patients with non-neoplastic disease confirmed on histological examination or serial neuroimaging were studied with 2-dimensional MRSI using point-resolved spectroscopic (PRESS) imaging localisation.
  • Normalised Cho (nCho) ratios, computed by dividing maximum Cho in the lesion by the normal-appearing brain, were compared between intracranial tumours and non-neoplastic disease.
  • CONCLUSION: Using semi-automated MRSI method, a simplified normalised Cho algorithm provides a method to distinguish intracranial tumours from non-neoplastic disease.
  • [MeSH-major] Brain Neoplasms / diagnosis. Diagnosis, Differential. Magnetic Resonance Spectroscopy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17549275.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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96. Urbanczyk C, Desal H, Ibrahim MR, Guillon B: [The finding of incidental intracranial lesions with magnetic resonance imaging]. Rev Neurol (Paris); 2005 Sep;161(8-9):862-7
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  • [Title] [The finding of incidental intracranial lesions with magnetic resonance imaging].
  • The most frequently detected lesions are intracranial tumors (meningioma, arachnoid cysts, neuro-epithelial tumor) and vascular malformations.
  • [MeSH-major] Brain Neoplasms / pathology. Intracranial Aneurysm / pathology. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Prevalence

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  • (PMID = 16244573.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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97. Andrade FG, de Aguiar PH, Matushita H, Taricco MA, Oba-Shinjo SM, Marie SK, Teixeira MJ: Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo. Arq Neuropsiquiatr; 2009 Sep;67(3A):626-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial and spinal ependymoma: series at Faculdade de Medicina, Universidade de São Paulo.
  • OBJECTIVE: Ependymomas are rare intracranial neuroepithelial tumors and the most common location is intramedullary.
  • METHOD: Data of clinical presentation, tumor location, duration of symptoms, degree of resection and complementary treatment of 34 patients with intracranial ependymoma and 31 with intramedullary ependymoma who underwent surgery in the last ten years were collected and correlated with the recurrence time and overall survival.
  • RESULTS: There was statistically significant correlation between the degree of resection and intracranial tumor location, although it is not a hallmark of recurrence.
  • CONCLUSION: The location of the intracranial tumor is connected with the degree of resection; however it is not a predictive factor to overall survival.
  • [MeSH-major] Brain Neoplasms / surgery. Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Disease-Free Survival. Female. Hospitals, University. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult

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  • (PMID = 19722039.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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98. Buhl R, Nabavi A, Wolff S, Hugo HH, Alfke K, Jansen O, Mehdorn HM: MR spectroscopy in patients with intracranial meningiomas. Neurol Res; 2007 Jan;29(1):43-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR spectroscopy in patients with intracranial meningiomas.
  • Apart from the known spectra and metabolites such as choline, creatine and N-acetyl-aspartate (NAA), recent publications have shown that lactate is often found in necrotic tumor tissue.
  • Within a 2 year period, 39 patients with an intracranial meningioma were studied with MRS.
  • [MeSH-major] Magnetic Resonance Spectroscopy / methods. Meningeal Neoplasms / diagnosis. Meninges / pathology. Meningioma / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Lactic Acid / analysis. Lactic Acid / metabolism. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Invasiveness / diagnosis. Neoplasm Recurrence, Local / diagnosis. Predictive Value of Tests. Tomography, X-Ray Computed

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  • (PMID = 17427274.001).
  • [ISSN] 0161-6412
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 33X04XA5AT / Lactic Acid
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99. Lee YH, Park EK, Park YS, Shim KW, Choi JU, Kim DS: Treatment and outcomes of primary intracranial teratoma. Childs Nerv Syst; 2009 Dec;25(12):1581-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment and outcomes of primary intracranial teratoma.
  • PURPOSE: Until recently, postoperative adjuvant treatment for intracranial teratomas has remained controversial because of the rarity of the tumors and the heterogeneity of histologic types.
  • To define optimal therapy modalities, we retrospectively analyzed the treatment of patients with intracranial teratomas.
  • METHODS: Between 1979 and 2007, 31 patients with intracranial teratomas were treated at our institution.
  • CONCLUSION: Treatment of intracranial teratomas is very difficult because of the heterogeneity of the tumor cells from totipotent origins.
  • [MeSH-major] Brain Neoplasms / therapy. Teratoma / therapy
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Drug Administration Schedule. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Treatment Outcome

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  • (PMID = 19693515.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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100. Ohta Y, Suzuki T, Tonoike T, Hamatani S, Ohike N, Shiokawa A, Kushima M, Ota H: Two cases of intracranial germinoma showing a cell arrangement mimicking carcinoma. Diagn Cytopathol; 2010 Feb;38(2):132-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two cases of intracranial germinoma showing a cell arrangement mimicking carcinoma.
  • We report two cases of intracranial germinoma, in which it was necessary to distinguish between intracranial germinoma and metastatic carcinoma in cytological specimens.
  • Cytologically, not only single tumor cells or loosely connective tumor cells but also closely packed clusters of cells and pair cells were recognized.
  • Immunocytochemically, almost all tumor cells were immunoreactive for M2A, placental alkaline phosphatase, and c-kit.
  • Therefore, Cytopathologists should be aware that tumor cell clusters, mimicking carcinoma might appear in cytological specimens of intracranial germinomas.
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma / pathology. Germinoma / pathology. Pineal Gland / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 20073098.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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