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1. Takahashi S, Yoshida K, Mikami S, Oya M, Kawase T: Development of testicular alpha-fetoprotein-secreting germ cell tumor 3 years after treatment of intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data--case report. Neurol Med Chir (Tokyo); 2008;48(11):522-5
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  • [Title] Development of testicular alpha-fetoprotein-secreting germ cell tumor 3 years after treatment of intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data--case report.
  • A 22-year-old Asian male developed testicular alpha-fetoprotein (AFP)-secreting germ cell tumor 3 years after treatment of a disseminated intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data.
  • Left orchidectomy was performed and histological examination indicated the presence of AFP-secreting germ cell tumor despite severe necrosis of the tissue.
  • Improved chemoradiotherapy for intracranial germ cell tumor will lead to long-term survival of most patients with germ cell tumor.
  • Patients may subsequently develop germ cell tumors at other sites in the body.
  • Therefore, follow up should monitor for tumor recurrence not only in the brain but also in other locations.
  • [MeSH-major] Neoplasm Proteins / analysis. Neoplasms, Germ Cell and Embryonal / secondary. Supratentorial Neoplasms / pathology. Testicular Neoplasms / secondary. alpha-Fetoproteins / analysis
  • [MeSH-minor] Carboplatin / administration & dosage. Combined Modality Therapy. Cranial Irradiation. Disease-Free Survival. Etoposide / administration & dosage. Follow-Up Studies. Hemianopsia / etiology. Humans. Magnetic Resonance Imaging. Male. Neoplasms, Second Primary / secretion. Neoplasms, Second Primary / surgery. Orchiectomy. Young Adult

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  • (PMID = 19029782.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / alpha-Fetoproteins; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
  • [Number-of-references] 12
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2. Villano JL, Propp JM, Porter KR, Stewart AK, Valyi-Nagy T, Li X, Engelhard HH, McCarthy BJ: Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries. Neuro Oncol; 2008 Apr;10(2):121-30
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  • [Title] Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries.
  • The exact incidence of pineal germ-cell tumors is largely unknown.
  • The tumors are rare, and the number of patients with these tumors, as reported in clinical series, has been limited.
  • The goal of this study was to describe pineal germ-cell tumors in a large number of patients, using data from available brain tumor databases.
  • Three different databases were used: Surveillance, Epidemiology, and End Results (SEER) database (1973-2001); Central Brain Tumor Registry of the United States (CBTRUS; 1997-2001); and National Cancer Data Base (NCDB; 1985-2003).
  • Tumors were identified using the International Classification of Diseases for Oncology, third edition (ICD-O-3), site code C75.3, and categorized according to histology codes 9060-9085.
  • A total of 1,467 cases of malignant pineal germ-cell tumors were identified: 1,159 from NCDB, 196 from SEER, and 112 from CBTRUS.
  • All three databases showed a male predominance for pineal germ-cell tumors (>90%), and >72% of patients were Caucasian.
  • The majority of tumors (73%-86%) were germinomas, and patients with germinomas had the highest survival rate (>79% at 5 years).
  • The proportions of malignant pineal germ-cell tumors and intracranial germ-cell tumors are in range with previous studies.
  • Survival rates for malignant pineal germ-cell tumors are lower than results from recent treatment trials for intracranial germ-cell tumors, and patients that received radiation therapy in the treatment plan either with surgery or alone survived the longest.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / epidemiology. Neoplasms, Germ Cell and Embryonal / therapy. Pinealoma / epidemiology. Pinealoma / therapy. Registries
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neurosurgical Procedures. Radiotherapy. Sex Distribution. Survival Rate

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  • (PMID = 18287340.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2613814
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3. Ammerlaan AC, Ararou A, Houben MP, Baas F, Tijssen CC, Teepen JL, Wesseling P, Hulsebos TJ: Long-term survival and transmission of INI1-mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome. Br J Cancer; 2008 Jan 29;98(2):474-9
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  • Two of these patients showed unusual long survival, and one of these developed an intracranial meningioma and a myoepithelioma of the lip in adulthood.
  • The myoepithelioma of one of the patients carried an identical somatic rearrangement in the NF2 gene as the AT/RT, indicating that both tumours originated from a common precursor cell.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Family. Genetic Predisposition to Disease. Germ-Line Mutation. Inheritance Patterns. Penetrance. Rhabdoid Tumor / genetics. Transcription Factors / genetics
  • [MeSH-minor] Adolescent. Adult. Base Sequence. Child, Preschool. Chromosomes, Human, Pair 22. DNA Mutational Analysis. Female. Humans. Infant. Male. Microsatellite Repeats / genetics. Pedigree. Sex Characteristics. Survival Analysis. Syndrome. Time Factors

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  • (PMID = 18087273.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2361463
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4. Andreu Martínez FJ, Martínez Mateu JM: Intracranial germ cell tumor mimicking anorexia nervosa. Clin Transl Oncol; 2006 Dec;8(12):915-8
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  • [Title] Intracranial germ cell tumor mimicking anorexia nervosa.
  • We report on a case of a 23 year-old female diagnosed as having a germ-cell tumour located in the sellar region.
  • This case shows that the presence of intracranial tumours next to the hypothalamus must be borne in mind as a rare but real possibility in cases of anorexia nervosa, specially in those non-typical cases.
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Amenorrhea / etiology. Anorexia / etiology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasms, Germ Cell and Embryonal / complications. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / therapy. Radiotherapy

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  • (PMID = 17169766.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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5. Bi WL, Bannykh SI, Baehring J: The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report. Neurosurgery; 2005;56(1):188
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  • [Title] The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report.
  • OBJECTIVE AND IMPORTANCE: We report a rare complication after resection of a recurrent intracranial nongerminomatous germ cell tumor in an adult.
  • The growing teratoma syndrome, as originally described with pediatric germ cell neoplasms, represents tumor recurrence, often cystic, that sometimes is observed after partial response to multimodality therapy and despite decreasing tumor serum markers.
  • The enlarging tumor consists of elements of a mature teratoma that presumably are refractory to chemotherapy or radiation.
  • To our knowledge, this is only the third case of the growing teratoma syndrome in an adult patient with nongerminomatous germ cell tumor.
  • CLINICAL PRESENTATION: A 26-year-old man had signs of recurrent obstructive hydrocephalus 6 months after multimodality treatment of a diencephalic yolk sac tumor and endoscopic third ventriculostomy.
  • Imaging studies revealed large multilocular cystic masses originating from the tumor bed and partially obstructing the ventriculostomy.
  • INTERVENTION: Near total tumor resection and fenestration was performed.
  • [MeSH-major] Brain Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / surgery. Neoplasms, Second Primary / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Adult. Humans. Male. Syndrome

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  • (PMID = 15617603.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Bi WL, Bannykh SI, Baehring J: The Growing Teratoma Syndrome after Subtotal Resection of an Intracranial Nongerminomatous Germ Cell Tumor in an Adult: Case Report. Neurosurgery; 2005 Jan 01;56(1):E191-E194

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Growing Teratoma Syndrome after Subtotal Resection of an Intracranial Nongerminomatous Germ Cell Tumor in an Adult: Case Report.

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  • (PMID = 28184632.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S: Teratomas in central nervous system: a clinico-morphological study with review of literature. Neurol India; 2010 Nov-Dec;58(6):841-6

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  • RESULTS: A total of 14 tumors were diagnosed as teratomas.
  • Of these, 11 were mature cystic teratomas; and 1 case each, of teratoma with malignant transformation, terato-carcinoma and mixed germ cell tumor (immature teratoma with germinoma).
  • Six of the 14 cases were intracranial and 8 were spinal.
  • Radiologically, contrast enhancement with predominantly solid component was suggestive of malignancy or an aggressive tumor.
  • Excision was curative or provided symptomatic relief in most cases; terato-carcinoma and mixed germ cell tumor patients needed adjuvant radiotherapy.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgery. Young Adult

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  • (PMID = 21150046.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
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8. Kim DS, Shim KW, Kim TG, Chang JH, Park YG, Choi JU: Pineal cavernous malformations: report of two cases. Yonsei Med J; 2005 Dec 31;46(6):851-8

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  • Pineal hemorrhage only occurs in rare cases, and this known to have several different causes such as germ cell tumors, pineal cysts and vascular malformations, including the cavernous malformations.
  • We operated and totally removed the tumor and the hemorrhages via an occipital-transtentorial approach. Case 2.
  • We operated and totally removed the tumor and the hemorrhages via an occipital-transtentorial approach.
  • [MeSH-major] Central Nervous System Vascular Malformations / radiography. Hematoma / radiography. Intracranial Hemorrhages / radiography. Pineal Gland
  • [MeSH-minor] Adult. Angiography. Diplopia / diagnosis. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 16385664.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2810602
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9. Nishioka H, Haraoka J, Miki T: Management of intracranial germ cell tumors presenting with rapid deterioration of consciousness. Minim Invasive Neurosurg; 2006 Apr;49(2):116-9
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  • [Title] Management of intracranial germ cell tumors presenting with rapid deterioration of consciousness.
  • OBJECTIVES: The value of surgical intervention in the management of intracranial germ cell tumors remains controversial.
  • PATIENTS: We report three patients who presented with rapid deterioration of consciousness but resulted in complete remission of the tumor after emergency surgery for both diagnostic (biopsy) and therapeutic (for hydrocephalus) purposes followed by prompt initiation of radiochemotherapy.
  • Thus, emergency surgery with a less invasive procedure is the first choice of treatment, i. e., endoscopic surgery for pineal region tumor and CT-guided biopsy for basal ganglia tumor.
  • [MeSH-major] Brain Neoplasms / surgery. Consciousness Disorders / etiology. Endodermal Sinus Tumor / surgery. Germinoma / surgery. Seminoma / surgery
  • [MeSH-minor] Adult. Child. Humans. Male. Testicular Neoplasms / pathology. Time Factors

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  • (PMID = 16708342.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. da Silva NS, Cappellano AM, Diez B, Cavalheiro S, Gardner S, Wisoff J, Kellie S, Parker R, Garvin J, Finlay J: Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study. Pediatr Blood Cancer; 2010 Mar;54(3):377-83
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  • [Title] Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study.
  • BACKGROUND: The treatment of central nervous system (CNS) germ cell tumors (GCT) remains controversial.
  • Twenty-five patients aged 4 months to 24.5 years were stratified: Regimen A consisted of 4-6 cycles of carboplatin/etoposide alternating with cyclophosphamide/etoposide for low risk (LR) localized germinoma with normal cerebrospinal fluid (CSF) and serum tumor markers.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Neoplasms, Germ Cell and Embryonal / drug therapy
  • [MeSH-minor] Adolescent. Adult. Carboplatin / administration & dosage. Carboplatin / adverse effects. Child. Child, Preschool. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Humans. Infant. Male. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 20063410.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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11. Luther N, Edgar MA, Dunkel IJ, Souweidane MM: Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors. J Neurooncol; 2006 Aug;79(1):45-50
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  • [Title] Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors.
  • We retrospectively analyzed the results of eight patients who underwent endoscopic biopsy of a newly diagnosed primary intracranial germ cell tumor (GCT), and correlated tumor pathology with serum and cerebrospinal fluid (CSF) tumor markers and treatment outcome in order to determine the reliability of GCT sampling by this method.
  • A biopsy diagnosis was made in each patient, and the tumor histology correlated with tumor marker measurements for all six patients diagnosed with germinoma and for one with a yolk sac tumor.
  • One biopsy revealed only mature teratoma, an inconclusive result since the patient's serum and CSF tumor markers were elevated.
  • We conclude that endoscopic biopsy of marker-negative germ cell tumors is a safe, reliable method of establishing a diagnosis of germinoma.
  • However, endoscopic biopsy may fail to yield an accurate diagnosis in cases of malignant non-germinomatous tumor.
  • We would thus conclude that when primary germ cell tumor is considered, endoscopic tumor biopsy is recommended in patients with a negative biochemical analysis, but not suggested for patients presenting with elevated tumor markers.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Neoplasms / pathology. Endoscopy. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Adolescent. Adult. Biopsy. Child. Child, Preschool. Chorionic Gonadotropin, beta Subunit, Human / blood. Chorionic Gonadotropin, beta Subunit, Human / cerebrospinal fluid. Diagnosis, Differential. Female. Germinoma / pathology. Humans. Magnetic Resonance Imaging. Male. Retrospective Studies. Teratoma / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 16598424.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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12. Schrödter S, Hakenberg O, Oehlschläger S, Fröhner M, Kittner T, Wirth M: [Acute abdominal pain due to a ventriculo-peritoneal shunt metastasis of an intracranial germ cell tumor]. Aktuelle Urol; 2006 Mar;37(2):141-2
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  • [Title] [Acute abdominal pain due to a ventriculo-peritoneal shunt metastasis of an intracranial germ cell tumor].
  • CASE REPORT: The case of a metastasis of a primary intracranial germ cell tumor via a temporary-ventriculo-peritoneal shunt as a cause of acute abdominal pain is reported.
  • The germ cell tumor markers were useful in establishing the diagnosis.
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Hydronephrosis / diagnosis. Hydronephrosis / etiology. Magnetic Resonance Imaging. Male. Reoperation. Ureteral Obstruction / diagnosis. Ureteral Obstruction / etiology

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  • (PMID = 16625472.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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13. Lee D, Suh YL: Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute. Virchows Arch; 2010 Sep;457(3):347-57
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  • [Title] Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute.
  • This study was undertaken to document the clinicopathologic characteristics of histologically verified, primary intracranial germ cell tumors (GCTs), determine treatment outcomes, and to identify prognostic factors.
  • The records of 62 patients (45 males and 17 females) with a primary intracranial GCT were retrospectively analyzed.
  • Germinomas and malignant non-germinomatous germ cell tumors were most prevalent in the pineal gland, suprasellar region, and basal ganglia, whereas teratomas dominated at other sites.
  • Five-year OSs in patients with normal tumor marker (alphaFP or betaHCG) and patients with elevated marker were 85.26% and 66.96%, respectively (P = 0.0568).
  • Sawamura's classification of intracranial GCT may be a fine tool for stratifying patients' survival.
  • Patients with elevated tumor marker levels may appear to have poorer OS independent of histology.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Kaplan-Meier Estimate. Korea. Male. Middle Aged. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 20652714.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Hayashi Y, Watanabe T, Nakada M, Kita D, Hayashi Y, Uchiyama N, Hamada J: BCL10 single nucleotide polymorphism and its association with CSF dissemination of primary intracranial germ cell tumors. Pediatr Neurosurg; 2009;45(4):291-5
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  • [Title] BCL10 single nucleotide polymorphism and its association with CSF dissemination of primary intracranial germ cell tumors.
  • BACKGROUND: Intracranial germ cell tumors (GCTs) are rare neoplasms.
  • Little is known about the pathogenesis of these tumors.
  • The BCL10 gene, a proapoptotic signaling molecule involved in the Apaf-1/caspase-9 cell death pathway, may act as a tumor suppressor gene in multiple types of tumors including testicular GCTs.
  • METHODS: To evaluate whether alterations in the BCL10 gene play a role in the genesis of intracranial GCTs, we analyzed the BCL10 gene in 10 pure germinomas (PGs) and 10 nongerminomatous GCTs.
  • CONCLUSIONS: Our data suggest that this specific SNP in the BCL10 gene may be partly responsible for the tumorigenesis of PG in Japanese individuals, and may be associated with the aggressive nature of these tumors.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Young Adult

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  • [Copyright] 2009 S. Karger AG, Basel
  • (PMID = 19690445.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BCL10 protein, human
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15. Huang X, Zhang R, Zhou LF: [Grading system for diagnosis and treatment of intracranial nongerminomatous malignant germ cell tumors]. Zhonghua Yi Xue Za Zhi; 2009 Sep 8;89(33):2333-6
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  • [Title] [Grading system for diagnosis and treatment of intracranial nongerminomatous malignant germ cell tumors].
  • OBJECTIVE: To discuss the clinical feature, treatment and prognosis of intracranial nongerminomatous malignant germ cell tumors (NGMGCT).
  • According to the classification of Matsutani, they were grouped into intermediate prognosis and poor prognosis groups based on tumor histology.
  • RESULTS: In these 39 cases, there were 15 mix germ cell tumors, 15 immature teratomas, 7 embryonal carcinomas and 2 yolk sac tumors.
  • The tumor was totally removed in 29 cases, sub-totally in 5 and partially in 3.
  • Embryonal carcinoma can be classified to the intermediate prognosis group because of its similar prognosis with immature teratoma and mixed tumors composed mainly of germinoma or teratoma.
  • Surgery remains the first choice for NGMGCT since treatment should be based on tumor histology.
  • [MeSH-major] Brain Neoplasms / classification. Neoplasms, Germ Cell and Embryonal / classification
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Humans. Male. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20095355.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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16. Kanamori M, Kumabe T, Saito R, Yamashita Y, Sonoda Y, Ariga H, Takai Y, Tominaga T: Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis. J Neurosurg Pediatr; 2009 Dec;4(6):506-14
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  • [Title] Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis.
  • OBJECT: This study retrospectively analyzed the long-term outcomes of 108 consecutive patients to establish the classification and optimal treatment strategy for each subgroup of newly diagnosed germ cell tumors (GCTs).
  • METHODS: A retrospective review of medical records from the authors' department between April 1989 and March 2007 identified 108 patients with newly diagnosed intracranial GCT.
  • Nongerminomatous GCTs were divided into good, intermediate, and poor prognosis groups as proposed by the Japanese Pediatric Brain Tumor Study Group.
  • Combined therapy of radiation therapy, chemotherapy, and radical resection as an initial or salvage treatment achieved excellent tumor control in the intermediate prognosis NGGCT group.
  • [MeSH-major] Brain Neoplasms / drug therapy. Brain Neoplasms / surgery. Germinoma / drug therapy. Germinoma / surgery. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / surgery. Radiotherapy, Adjuvant
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Infant. Kaplan-Meier Estimate. Longitudinal Studies. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Radiation Dosage. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19951035.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Ohta Y, Suzuki T, Tonoike T, Hamatani S, Ohike N, Shiokawa A, Kushima M, Ota H: Two cases of intracranial germinoma showing a cell arrangement mimicking carcinoma. Diagn Cytopathol; 2010 Feb;38(2):132-6
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  • [Title] Two cases of intracranial germinoma showing a cell arrangement mimicking carcinoma.
  • Tumors of germ cell origin uncommonly arise in extragonadal sites.
  • We report two cases of intracranial germinoma, in which it was necessary to distinguish between intracranial germinoma and metastatic carcinoma in cytological specimens.
  • Cytologically, not only single tumor cells or loosely connective tumor cells but also closely packed clusters of cells and pair cells were recognized.
  • Immunocytochemically, almost all tumor cells were immunoreactive for M2A, placental alkaline phosphatase, and c-kit.
  • Therefore, Cytopathologists should be aware that tumor cell clusters, mimicking carcinoma might appear in cytological specimens of intracranial germinomas.
  • Although immunocytochemical analysis assists in correct diagnosis, some cell clusters showing cytokeratin immunoreactivity does not become the basis for the diagnosis of metastatic carcinoma.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 20073098.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Chitapanarux I, Lorvidhaya V, Kamnerdsupaphon P, Goss B, Ford J: CNS germ cell tumors: pattern of failure and effects of radiation volume. J Med Assoc Thai; 2006 Apr;89(4):415-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CNS germ cell tumors: pattern of failure and effects of radiation volume.
  • This retrospective study was conducted to evaluate local control and overall survival after radiotherapy for patients with intracranial germ cell tumors and to investigate the influence of irradiated field on treatment outcome.
  • Thirty-two patients with surgically confirmed or suspected primary intracranial germ cell tumors (GCT) treated at the Division of Therapeutic Radiology and Oncology, Chiang Mai University, Chiang Mai, Thailand between January 1988 and December 1999 were reviewed Seven patients were not included in the analysis of treatment outcome and survival due to incompleteness of radiation treatment or death before the end of treatment.
  • Patients were irradiated to the primary tumor with an adequate margin in 7 patients, to the whole brain with a cone down boost in 8 patients.
  • [MeSH-major] Central Nervous System Neoplasms / radiotherapy. Neoplasm Recurrence, Local. Neoplasms, Germ Cell and Embryonal / radiotherapy. Treatment Outcome
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Male. Middle Aged. Pinealoma / mortality. Pinealoma / radiotherapy. Retrospective Studies. Risk Factors. Survival Rate. Thailand / epidemiology

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  • (PMID = 16696383.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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19. Kiymaz N, Cirak B, Yilmaz N: Metastatic germ cell testicular tumor of the eye and brain: case report. Acta Neurol Belg; 2005 Sep;105(3):178-9
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  • [Title] Metastatic germ cell testicular tumor of the eye and brain: case report.
  • Intraocular metastatic tumors are rarely encountered pathologies.
  • Here we describe a case of intraocular metastatic tumor to the vitreus originating from testicular embryonal cell carcinoma.
  • Patient with intraocular tumor had also intracranial metastasis.
  • He was operated on for intracranial lesion, after an uneventfull postoperative period he was discharged.
  • 2 months later when he died, postmortem examination of the intraocular lesion reported as metastatic embryonal cell carcinoma.
  • As a conclusion testicular embryonal cell carcinoma, eventhough rare, must be considered to metastasize to the eye.
  • [MeSH-major] Brain Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / secondary. Orbital Neoplasms / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 16255156.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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20. Yao B, Li JJ, Liu X, Li WM, Yan JH, Weng JP: [The clinical characteristics of primary intracranial germinoma]. Zhonghua Nei Ke Za Zhi; 2005 Nov;44(11):840-3
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  • [Title] [The clinical characteristics of primary intracranial germinoma].
  • OBJECTIVE: To analyse the clinical characteristics of intracranial germinoma.
  • METHODS: Retrospective analysis was applied to study the clinical characteristics of 26 intracranial germ cell tumor patients admitted to our hospital during 1991-2003.
  • RESULTS: 26 intracranial germ cell tumor patients were admitted to our hospital during 1991-2003, accounting for 0.9% of all intracranial tumors (3020 cases) at the same time.
  • Among these patients 19 cases (73.1%) were primary intracranial germinoma, 9 patients (47.4%) were female and 10 patients (52.6%) were male.
  • 9 patients' tumors (47.3%) were in pine region, 7 patients' tumors (38.8%) were in sellar region.
  • CONCLUSIONS: Intracranial germinoma mainly affects female children and adolescents, pine and suprasellar regions are the commonly involved regions, the most common manifestations of intracranial germinoma are headache, vomiting, nausea, diabetes insipidus and hypopituitarism.
  • Radiotherapy has good efficacy in the treatment of intracranial germinoma.
  • [MeSH-minor] Adolescent. Adult. Child. Chorionic Gonadotropin, beta Subunit, Human / blood. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. alpha-Fetoproteins / analysis

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  • (PMID = 16316566.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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21. Matsumoto J, Kochi M, Morioka M, Nakamura H, Makino K, Hamada J, Kuratsu J, Ushio Y: A long-term ventricular drainage for patients with germ cell tumors or medulloblastoma. Surg Neurol; 2006 Jan;65(1):74-80; discussion 80
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  • [Title] A long-term ventricular drainage for patients with germ cell tumors or medulloblastoma.
  • BACKGROUND: Hydrocephalus associated with intracranial germ cell tumors or disseminated medulloblastoma has been treated with ventriculoperitoneal shunt.
  • However, this procedure has a potential risk of intraperitoneal metastasis of these brain tumors.
  • METHODS: From 1979 to 2003, we have treated 96 patients with germ cell tumors and medulloblastoma in our hospital.
  • Of 96 patients, 59 (germ cell tumor, 31; medulloblastoma, 28) had hydrocephalus and 13 needed long-term cerebrospinal fluid drainage to manage the obstructive hydrocephalus due to persistent tumor or communicating hydrocephalus due to dissemination.
  • CONCLUSIONS: Percutaneous long-tunneled ventricular drainage was an effective method to manage long-lasting obstructive or communicating hydrocephalus with germ cell tumors and medulloblastoma.
  • [MeSH-major] Brain Neoplasms / complications. Hydrocephalus / etiology. Hydrocephalus / surgery. Medulloblastoma / complications. Neoplasms, Germ Cell and Embryonal / complications. Ventriculoperitoneal Shunt
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Incidence. Infant. Infection / epidemiology. Male. Postoperative Complications / epidemiology. Retrospective Studies. Time Factors


22. Goodwin TL, Sainani K, Fisher PG: Incidence patterns of central nervous system germ cell tumors: a SEER Study. J Pediatr Hematol Oncol; 2009 Aug;31(8):541-4
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  • [Title] Incidence patterns of central nervous system germ cell tumors: a SEER Study.
  • BACKGROUND: Incidence patterns of central nervous system (CNS) germ cell tumors (GCTs) have been reported, but the influence of underlying host risk factors has not been rigorously explored.
  • The cases were limited to only those with the International Classification of Childhood Cancer Xa: intracranial and intraspinal germ-cell tumors.
  • Incidence rates (per 10,000) for each sex and race were plotted for single-age groups, and then stratified by tumor location and pathology subtype.
  • Tumor location differed strikingly by sex (P<0.0001) with pineal location more common in males (61.0% vs. 15.5%).
  • [MeSH-major] Central Nervous System Neoplasms / epidemiology. Neoplasms, Germ Cell and Embryonal / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Female. Humans. Incidence. Male. Middle Aged. Registries. Retrospective Studies. Sex Factors. Young Adult

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  • (PMID = 19636276.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Utsuki S, Oka H, Tanizaki Y, Kondo K, Kawano N, Fujii K: Pathological features of intracranial germinomas with reference to fibrous tissue and granulomatous change. Brain Tumor Pathol; 2005;22(1):9-13
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  • [Title] Pathological features of intracranial germinomas with reference to fibrous tissue and granulomatous change.
  • Intracranial germinomas are accompanied occasionally by a significant granulomatous change and abundant fibrous tissue, and this has made their pathological diagnosis difficult.
  • However, the incidence of the granulomatous reaction and the presence of fibrous tissue together with their clinical characteristics in intracranial germinomas have not been fully investigated.
  • The location of the tumor was the pineal region (5 cases), the suprasellar region (13 cases), multiple lesions (2 cases), the basal ganglia region (1 case), and other regions (3 cases).
  • (1) type A (18 cases) consisted mainly of large neoplastic cells and small lymphocytes, showing a two-cell pattern;.
  • Perioperatively, two-cell-pattern germinomas (type A) were characterized as soft tumors and fibroinflammatory germinomas (type B) as hard tumors.
  • Thus, the fibroinflammatory type B accounted for 25% of the intracranial germinomas.
  • Although there were no topographical and clinical differences between the two types, we conclude that immunohistological studies to detect neoplastic germ cells are warranted in cases of small stereotactic biopsies of hard type B tumors.
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Young Adult

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  • (PMID = 18095098.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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24. Kamakura Y, Hasegawa M, Minamoto T, Yamashita J, Fujisawa H: C-kit gene mutation: common and widely distributed in intracranial germinomas. J Neurosurg; 2006 Mar;104(3 Suppl):173-80
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  • [Title] C-kit gene mutation: common and widely distributed in intracranial germinomas.
  • OBJECT: Of the intracranial germ cell tumors (IGCTs), 10% of germinomas and most nongerminomatous tumors remain refractory to multimodality therapy.
  • The authors investigated the mutation of c-kit and the expression of its product KIT in IGCTs to identify tumors susceptible to imatinib mesylate, a synthetic agent targeting KIT.
  • METHODS: The authors investigated 26 IGCTs, including 13 germinomas, five mixed germ cell tumors (MGCTs), four immature teratomas (ITs), and two each of yolk sac tumors and choriocarcinomas.
  • These tumors were examined for the expression of KIT and CD34 by immunohistochemical analysis, and for mutations in exons 2, 8 to 11, 13, and 17 of c-kit.
  • Strong KIT expression was found in the cell membrane of germinomas (100%) and germinomatous cells of MGCTs (80%), as well as in the cytoplasm of epithelial and smooth-muscle cells of ITs.
  • The membranous expression of CD34 was found in the nongerminomatous tumor cells and the chondrocytes of MGCTs (60%), ITs (100%), and a choriocarcinoma (50%), but not in germinomas and germinomatous cells.
  • The novel mutations E73K, T96M (both in exon 2), and A636V (in exon 13) were detected in a single tumor.
  • This study may help in clarifying the pathogenesis of IGCTs and in identifying tumors susceptible to drugs targeting KIT.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA Mutational Analysis. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Mutation, Missense. Prognosis

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  • (PMID = 16572634.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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25. Kan P, Gottfried ON, Blumenthal DT, Liu JK, Salzman KL, Townsend J, Jensen RL: Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature. J Neurooncol; 2006 Jul;78(3):249-53
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  • [Title] Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature.
  • OBJECT: Central nervous system primary germ cell tumors are typically pineal or suprasellar.
  • Primary germ cell tumors of the spinal axis are very rare, with only a few case reports of germinomas and teratomas described in the literature.
  • METHODS: We present the unique case of a 25-year-old woman with an intradural, extramedullary primary yolk sac tumor (YST) at and below the level of the conus medullaris.
  • Despite an initial reduction in tumor size and clinical improvement in her neurologic exam, she re-presented a year after surgery with gross enlargement of her spinal tumor and CSF dissemination with metastasis to her brain.
  • CONCLUSIONS: This case demonstrates that primary YSTs may occur in the spine, and like their intracranial counterparts, are associated with poor prognosis and dissemination through the neuroaxis.
  • When feasible (no evidence of CSF dissemination, metastasis, or multifocal disease), optimal treatment includes as extensive resection of tumor as possible followed by adjuvant chemotherapy and radiation.
  • The authors review the available literature on the treatment of intracranial malignant germ cell tumors, extrapolated to apply to the much rarer spinal lesions.
  • [MeSH-major] Brain Neoplasms / secondary. Endodermal Sinus Tumor / secondary. Neoplasm Recurrence, Local / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans

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  • (PMID = 16773223.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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26. Kobayashi H, Sawamura Y, Ikeda J: A tumor in the medulla oblongata producing beta-HCG and AFP. J Clin Neurosci; 2005 Aug;12(6):709-11
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  • [Title] A tumor in the medulla oblongata producing beta-HCG and AFP.
  • An intracranial non-germinomatous germ cell tumour (NGGCT) was strongly suspected.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods

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  • (PMID = 16098752.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / alpha-Fetoproteins; 319-85-7 / beta-hexachlorocyclohexane; 59NEE7PCAB / Lindane
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27. Nicolato A, Ria A, Foroni R, Manno P, Alessandrini F, Sava T, Lupidi F, Leone P, Maluta S, Cetto GL, Gerosa M: Gamma knife radiosurgery in brain metastases from testicular tumors. Med Oncol; 2005;22(1):45-56
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  • [Title] Gamma knife radiosurgery in brain metastases from testicular tumors.
  • To our knowledge, there are no published reports on the effectiveness of radiosurgery in the management of brain metastases from testicular nonseminomatous germ cell tumor.
  • The authors evaluate the results of gamma knife (GK) treatment in three patients with these unusual intracranial lesions.
  • Between April 1995 and July 2001, three patients with brain metastasis from testicular nonseminomatous germ cell tumor underwent adjuvant radiosurgery at our department.
  • The primary tumor had been surgically removed in all cases.
  • The indications for radiosurgery were tumor volume <20 cm3, microsurgery too risky, refusal of surgery.
  • Post-GK high-dose chemotherapy with autologous peripheral-blood stem-cell rescue was administered in two cases due to systemic recurrence of the disease.
  • Neuroradiological follow-up invariably showed tumor growth control (complete response in two cases and partial response in one) with typically delayed post-radiosurgical imaging changes (transient in two cases and long-lasting in one).
  • In conclusion, GK seems to be highly effective and safe in brain metastases from testicular nonseminomatous germ cell tumor.
  • [MeSH-major] Brain Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / secondary. Radiosurgery / methods. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 15750196.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Kanamori M, Kumabe T, Saito R, Yamashita Y, Sonoda Y, Tominaga T: [The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases]. No Shinkei Geka; 2010 Nov;38(11):997-1005
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  • PURPOSE: The adverse effects of combination chemotherapy of ifosfamide, cisplatin, and etoposide (ICE) were evaluated in the treatment of various intracranial brain tumors.
  • The histological diagnosis was newly diagnosed or recurrent germ cell tumor in 45 cases, medulloblastoma in 19, primitive neuroectodermal tumor (PNET) in 7, anaplastic ependymoma in 6, recurrent glioblastoma in 13, and others in 18 cases.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / adverse effects. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / adverse effects. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Agents, Phytogenic / adverse effects. Child. Child, Preschool. Cisplatin / administration & dosage. Cisplatin / adverse effects. Ependymoma / drug therapy. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Glioblastoma / drug therapy. Hematologic Diseases / chemically induced. Humans. Ifosfamide / administration & dosage. Ifosfamide / adverse effects. Infant. Male. Medulloblastoma / drug therapy. Middle Aged. Neoplasms, Germ Cell and Embryonal / drug therapy. Neuroectodermal Tumors, Primitive / drug therapy. Retrospective Studies

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  • (PMID = 21081811.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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29. Nakamura H, Takeshima H, Makino K, Kuratsu J: C-kit expression in germinoma: an immunohistochemistry-based study. J Neurooncol; 2005 Nov;75(2):163-7
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  • In our immunohistochemical study of 25 human primary intracranial germinomas and germinomas with syncytiotrophoblastic giant cells (STGC), we stained the same sections for c-kit and placental alkaline phosphatase (PLAP).
  • All 3 cases negative for PLAP-staining were strongly positive and all embryonal carcinomas, immature teratomas, and yolk sac tumors were negative for c-kit staining.
  • C-kit and s-kit may be powerful tumor markers for germinomas with or without STGC.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Brain Neoplasms / metabolism. Germinoma / metabolism. Immunohistochemistry. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Adolescent. Adult. Alkaline Phosphatase / metabolism. Child. Child, Preschool. Female. Humans. Isoenzymes / metabolism. Male. Retrospective Studies. Trophoblasts / cytology

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  • (PMID = 16132509.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / germ-cell AP isoenzyme; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.1.3.1 / Alkaline Phosphatase
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30. Aker FV, Berkman ZM, Aydingöz I, Hakan T, Toksoy G: Pineal germinoma associated with multiple congenital melanocytic nevi: a unique presentation. Neuropathology; 2005 Dec;25(4):336-40
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  • Intracranial germ cell tumors are rarely seen and typically localize in the pineal or suprasellar region.
  • The largest category of germ cell tumors is the germinoma.
  • There have been reported associations of malignant tumors and chromosomal abnormalities in germ cell tumors.
  • In this study, we present a 22-year-old man with multiple congenital melanocytic nevi in association with pineal tumor.
  • The pathological diagnosis of the pineal tumors was germinoma, and the lesions located in the occipital region and trunk were compound congenital nevi.
  • To our knowledge, a relationship between multiple congenital melanocytic nevi and germ cell tumors has not been reported before.
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male

  • Genetic Alliance. consumer health - Germinoma.
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  • (PMID = 16382782.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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31. Qiu BH, Fang LX, Zhang XA, Qi ST: [Clinical study of pineal region tumors: experience with 132 patients]. Zhonghua Zhong Liu Za Zhi; 2010 Jun;32(6):441-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study of pineal region tumors: experience with 132 patients].
  • OBJECTIVE: To review the clinical manifestations, imaging, tumor markers, treatment methods, pathology results and clinical curative effects of pineal region tumors and to evaluate the characteristics and intervention strategies for those tumors.
  • METHODS: The clinicopathological data of 132 patients with pineal region tumor treated in our department between January 2000 and May 2008 were retrospectively studied.
  • The clinical manifestations of the disease included increased intracranial pressure and ocular movement impairment.
  • 114 cases had pathology results including 56 germ cell tumors.
  • CONCLUSION: Pineal region tumors are often associated with hydrocephalus and this makes preoperative diagnosis difficult.
  • Germ cell tumors may diagnosed by some tumor markers.
  • Other types of pineal region tumors should receive surgical treatment.
  • Postoperative adjuvant treatment based on pathology can provide a good prognosis in pineal region tumor.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Chorionic Gonadotropin / blood. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Hydrocephalus / etiology. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Sex Factors. Survival Rate. Tomography, X-Ray Computed. Young Adult. alpha-Fetoproteins / metabolism

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  • (PMID = 20819486.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / alpha-Fetoproteins
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32. Gabeau-Lacet D, Grant E, Stemmer-Rachamimov A, Yock T, Tarbell NJ: Sellar abnormalities in female first-degree relatives. Clin Neurol Neurosurg; 2008 Feb;110(2):202-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Each of these cases was diagnosed and managed differently, illustrating the relative importance of radiographic imaging, tumor markers and histopathologic examination in the diagnosis and treatment of intracranial disease.
  • One daughter was treated presumptively for germinoma based on characteristic radiographic studies and slightly elevated tumor marker.
  • The other daughter's lesion exhibited radiographic characteristics concerning for pituitary macroadenoma but with slightly elevated germ cell tumor marker, raising the suspicion for germinoma.
  • [MeSH-minor] Adult. Child. Female. Humans

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  • (PMID = 18035480.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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33. Tian ZM, Wang YM, Yu X, Zhao QJ, Hui R, Liu R, Li ZC: [Clinical experience of stereotactic biopsy for the brain lesions]. Zhonghua Wai Ke Za Zhi; 2010 Oct 1;48(19):1459-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The positive diagnosis rate of biopsy was 97.4%, 983 (82.8%) cases were diagnosed pathologically as brain tumors, and 173 (14.6%) cases as non-tumor diseases.
  • The tumors mainly including neuroglioma, metastatic tumor, primary central nervous system lymphoma and germ cell tumors.
  • In non-tumor diseases, mainly including multiple sclerosis, tumefactive demyelinating lesion, neurodegenerative disease, inflammation and parasite.
  • There were no severe intracranial infection cases.
  • CONCLUSIONS: The stereotactic biopsy with advanced image-guided technique represents a safe, reliable and minimally invasive method for pathological diagnosis of intracranial lesions.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 21176652.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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