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6. Naini AB, Lu J, Kaufmann P, Bernstein RA, Mancuso M, Bonilla E, Hirano M, DiMauro S: Novel mitochondrial DNA ND5 mutation in a patient with clinical features of MELAS and MERRF. Arch Neurol; 2005 Mar;62(3):473-6
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  • PATIENT: A 25-year-old man had recurrent strokes, seizures, and myoclonus.
  • [MeSH-minor] Adult. Amino Acid Sequence. Humans. Male. Mitochondrial Proteins. Molecular Sequence Data. Succinate Dehydrogenase / genetics. Succinate Dehydrogenase / metabolism

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  • (PMID = 15767514.001).
  • [ISSN] 0003-9942
  • [Journal-full-title] Archives of neurology
  • [ISO-abbreviation] Arch. Neurol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS11766; United States / NICHD NIH HHS / HD / P01HD32062
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / Mitochondrial Proteins; 0 / Protein Subunits; EC 1.3.99.1 / Succinate Dehydrogenase; EC 1.6.5.3 / Electron Transport Complex I; EC 1.6.99.3 / ND5 protein, human
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7. Kennedy CM, Nygaard IE, Bradley CS, Galask RP: Bladder and bowel symptoms among women with vulvar disease: are they universal? J Reprod Med; 2007 Dec;52(12):1073-8
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  • [Title] Bladder and bowel symptoms among women with vulvar disease: are they universal?
  • OBJECTIVE: To compare the prevalence of painful bladder syndrome, recurrent urinary tract infections, urinary leakage and irritable bowel syndrome between women with specific vulvar disorders and controls.
  • RESULTS: As compared to controls, painful bladder syndrome was more prevalent among subjects with dysplasia, vestibulitis and contact vulvitis; a history of recurrent urinary tract infection was more prevalent among subjects with contact vulvitis; and urinary incontinence was less prevalent in subjects with lichen sclerosus.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Comorbidity. Cross-Sectional Studies. Female. Humans. Middle Aged. Pain / epidemiology. Prevalence. Recurrence. Surveys and Questionnaires. Urinary Incontinence / epidemiology. Urinary Tract Infections / epidemiology

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  • (PMID = 18210896.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / 1K23 HD045769-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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8. Jeon GH, Kim SR, Kim SH, Chae HD, Kim CH, Kang BM: Etiologic characterization of recurrent miscarriages in Koreans. J Reprod Med; 2009 Sep;54(9):569-75
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  • [Title] Etiologic characterization of recurrent miscarriages in Koreans.
  • OBJECTIVE: To investigate recurrent miscarriages in Koreans in terms of causative factors and the prognosis for subsequent successful pregnancies in primary and secondary recurrent miscarriages cases.
  • STUDY DESIGN: The study retrospectively examined the clinical records of 222 recurrent miscarriage cases that were presented at the Department of Obstetrics and Gynecology, Asan Medical Center, Seoul, Korea, from July 1989 to June 2008.
  • RESULTS: The etiologic analysis indicated that anatomic abnormality (29.4%) was the most common cause of recurrent miscarriage in Koreans, followed by immunologic (26.7%), inexplicable (24.1%), endocrinologic (15.0%) and genetic (11.2%) causes.
  • The subsequent successful pregnancy rate was higher in the secondary recurrent miscarriage group than the primary recurrent miscarriage group (47.9% vs. 31.7%, p < 0.05).
  • CONCLUSION: The causative factors of recurrent miscarriages in Koreans differed from those reported in Western studies on the frequency of causes.
  • The prognosis for subsequent successful pregnancies was better in the secondary recurrent miscarriage group, as we expected.
  • [MeSH-minor] Adult. Female. Humans. Korea. Pregnancy. Pregnancy Rate. Prognosis. Recurrence. Retrospective Studies

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  • (PMID = 19947035.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Alvarado DM, Aferol H, McCall K, Huang JB, Techy M, Buchan J, Cady J, Gonzales PR, Dobbs MB, Gurnett CA: Familial isolated clubfoot is associated with recurrent chromosome 17q23.1q23.2 microduplications containing TBX4. Am J Hum Genet; 2010 Jul 9;87(1):154-60
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  • [Title] Familial isolated clubfoot is associated with recurrent chromosome 17q23.1q23.2 microduplications containing TBX4.
  • A recurrent chromosome 17q23.1q23.2 microduplication was identified in 3 of 66 probands with familial isolated clubfoot.
  • [MeSH-minor] Abnormalities, Multiple / genetics. Adult. Child. Child, Preschool. Female. Gene Duplication. Humans. Male. Musculoskeletal Abnormalities / genetics. Pedigree. Penetrance

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  • [Copyright] Copyright 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20598276.001).
  • [ISSN] 1537-6605
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12 HD001459; United States / NIAMS NIH HHS / AR / P30 AR057235
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / T-Box Domain Proteins; 0 / TBX4 protein, human
  • [Other-IDs] NLM/ PMC2896772
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10. Weitmann HD, Knocke TH, Waldhäusl C, Pötter R: Ultrasound-guided interstitial brachytherapy in the treatment of advanced vaginal recurrences from cervical and endometrial carcinoma. Strahlenther Onkol; 2006 Feb;182(2):86-95
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  • 14 patients died of tumor and two of intercurrent disease.
  • 5-year disease-specific survival and local control rate were 43% and 47%, respectively, in patients with complete remission.
  • CONCLUSION: The use of ultrasound guidance for placement of interstitial needles in template-based brachytherapy of advanced recurrent gynecologic malignancies is a feasible, safe, and cheap method with encouraging results.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Survival Analysis


11. Longacre TA, McKenney JK, Tazelaar HD, Kempson RL, Hendrickson MR: Ovarian serous tumors of low malignant potential (borderline tumors): outcome-based study of 276 patients with long-term (&gt; or =5-year) follow-up. Am J Surg Pathol; 2005 Jun;29(6):707-23
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  • The histology of the ovarian primary, extraovarian implants, and recurrent tumor(s) were characterized using World Health Organization criteria and correlated with FIGO stage and clinical follow-up.
  • After censoring nontumor deaths, overall survival and disease-free survival for the 276 patients was 95% (98% FIGO stage I; 91% FIGO II-IV) and 78% (87% FIGO stage I; 65% FIGO stage II-IV), respectively.
  • Unresectable disease (P < 0.001) and invasive implants (P < 0.001) were associated with decreased survival.
  • Stromal microinvasion in the primary tumor was also correlated with adverse outcome, independent of stage of disease, micropapillary architecture, and implant type (P = 0.03).
  • Transformation to low-grade serous carcinoma occurred in 6.8% of patients at intervals of 7 to 288 months (58% > or = 60 months) and was strongly associated with increased tempo of disease and decreased survival (P < 0.001).
  • The majority of S-LMP are clinically benign, but recurrences are not uncommon, and persistent disease as well as deaths occur.
  • Progression to low-grade serous carcinoma is highly predictive of more aggressive disease.
  • Other features associated with recurrent and/or progressive disease include FIGO stage, invasive implants, microinvasion in the primary tumor, and micropapillary architecture.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Transformation, Neoplastic. Child. Disease Progression. Female. Humans. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Retrospective Studies. Survival Analysis

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  • (PMID = 15897738.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Díaz CJ, Núñez AC, Flores MI, Arcaute HD, Archondo T: [Haemostatic and inflammation markers in acute coronary syndromes and its relationship with adverse cardiovascular events]. Arch Cardiol Mex; 2006 Oct-Dec;76(4):366-75
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  • BACKGROUND: In acute coronary syndromes (ACS) interaction among several haemostatic (S and C protein, antitrhombin Ill, C protein resistance, plasminogen, alpha 2-antiplasmi and inflammatory factors (white cell blood count, fibrinogen, reactive C protein) could have association with recurrent thrombosis and recurrence ischemia, reinfarction, shock and cardiovascular mortality.
  • CONTROL GROUPS: Healthy individuals and stable chronic heart disease patients whose were matched by age and sex.
  • In all patients with ischemic heart disease angiography, nuclear medicine or echocardiography stress tests were done.
  • Protein C and S, protein C resistance and antithrombin III had correlation with death (p 0.0001) and recurrent ischemia (p < 0.0001).
  • [MeSH-minor] Acute Disease. Adult. Age Factors. Aged. Biomarkers. C-Reactive Protein / analysis. Data Interpretation, Statistical. Female. Follow-Up Studies. Hospital Mortality. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Recurrence. Risk Factors. Sex Factors. Syndrome. Time Factors

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  • (PMID = 17315612.001).
  • [ISSN] 1405-9940
  • [Journal-full-title] Archivos de cardiología de México
  • [ISO-abbreviation] Arch Cardiol Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Blood Coagulation Factors; 9007-41-4 / C-Reactive Protein
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13. Jaureguiberry G, Carpenter TO, Forman S, Jüppner H, Bergwitz C: A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc. Am J Physiol Renal Physiol; 2008 Aug;295(2):F371-9
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  • The present study describes two novel compound heterozygous mutations, c.410C>T(p.T137M) (T137M) on the maternal and g.4225_50del on the paternal allele of SLC34A3, in a previously reported male with hereditary hypophosphatemic rickets with hypercalciuria (HHRH) and recurrent kidney stones (Chen C, Carpenter T, Steg N, Baron R, Anast C.

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  • (PMID = 18480181.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK078361; United States / NIDDK NIH HHS / DK / R03 DK089127; United States / NICHD NIH HHS / HD / K24-HD-01288; United States / NIDDK NIH HHS / DK / P01-DK-11794
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphates; 0 / SLC34A3 protein, human; 0 / Sodium-Phosphate Cotransporter Proteins; 0 / Sodium-Phosphate Cotransporter Proteins, Type IIc; 2ZD004190S / Threonine; 9NEZ333N27 / Sodium
  • [Other-IDs] NLM/ NIHMS61403; NLM/ PMC2519180
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4. Peipert J, Redding CA, Blume J, Allsworth JE, Iannuccillo K, Lozowski F, Mayer K, Morokoff PJ, Rossi JS: Design of a stage-matched intervention trial to increase dual method contraceptive use (Project PROTECT). Contemp Clin Trials; 2007 Sep;28(5):626-37
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  • The primary outcomes of this trial were 1) self-reported use of dual methods of contraception and 2) the biological outcomes of an unintended pregnancy or an incident or recurrent sexually transmitted disease.

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  • (PMID = 17374567.001).
  • [ISSN] 1551-7144
  • [Journal-full-title] Contemporary clinical trials
  • [ISO-abbreviation] Contemp Clin Trials
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD036663; United States / NICHD NIH HHS / HD / 1R01-HD36663-01; United States / NICHD NIH HHS / HD / K24 HD01298-03
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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15. Nessim SJ, Bargman JM, Austin PC, Nisenbaum R, Jassal SV: Predictors of peritonitis in patients on peritoneal dialysis: results of a large, prospective Canadian database. Clin J Am Soc Nephrol; 2009 Jul;4(7):1195-200
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  • Study variables included age, gender, race, cause of renal disease, diabetes status, transfer from hemodialysis (HD), previous renal transplant, and continuous ambulatory PD (CAPD) versus automated PD (APD).
  • Using the negative binomial regression model, factors that were independently associated with a higher peritonitis rate included age, Black race, and having transferred from HD.
  • The Andersen-Gill model for recurrent events yielded similar results.
  • CONCLUSIONS: Predictors of PD peritonitis included Black race, transferring from HD to PD, and diabetes among women.
  • [MeSH-minor] Adult. African Continental Ancestry Group / statistics & numerical data. Aged. Canada / epidemiology. Databases, Factual. Diabetes Complications / epidemiology. Female. Humans. Incidence. Male. Middle Aged. Multivariate Analysis. Predictive Value of Tests. Regression Analysis. Renal Dialysis / statistics & numerical data. Risk Factors. Sex Distribution

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  • (PMID = 19406969.001).
  • [ISSN] 1555-905X
  • [Journal-full-title] Clinical journal of the American Society of Nephrology : CJASN
  • [ISO-abbreviation] Clin J Am Soc Nephrol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2709510
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16. Park L, Delaney TF, Liebsch NJ, Hornicek FJ, Goldberg S, Mankin H, Rosenberg AE, Rosenthal DI, Suit HD: Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys; 2006 Aug 1;65(5):1514-21
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  • [Title] Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor.
  • METHODS AND MATERIALS: The records of 16 primary and 11 recurrent sacral chordoma patients treated from November 1982 to November 2002 by proton/photon radiation therapy alone (6 patients) or combined with surgery (21 patients) have been analyzed for local control, survival, and treatment-related morbidity.
  • RESULTS: Outcome results show a large difference in local failure rate between patients treated for primary and recurrent chordomas.
  • Local control results by surgery and radiation were 12/14 vs. 1/7 for primary and recurrent lesions.
  • For margin-positive patients, local control results were 10 of 11 and 0 of 5 in the primary and recurrent groups, respectively; the mean follow-up on these locally controlled patients was 8.8 years (4 at 10.3, 12.8, 17, and 21 years).
  • CONCLUSION: These data indicate a high local control rate for surgical and radiation treatment of primary (12 of 14) as distinct from recurrent (1 of 7) sacral chordomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Photons / therapeutic use. Protons / therapeutic use. Survival Analysis. Treatment Outcome

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  • (PMID = 16757128.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA21239
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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17. Kim SW, Shin HC, Kim IY, Baek MJ, Cho HD: Foreign body granulomas simulating recurrent tumors in patients following colorectal surgery for carcinoma: a report of two cases. Korean J Radiol; 2009 May-Jun;10(3):313-8
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  • [Title] Foreign body granulomas simulating recurrent tumors in patients following colorectal surgery for carcinoma: a report of two cases.
  • We report here two cases of foreign body granulomas that arose from the pelvic wall and liver, respectively, and simulated recurrent colorectal carcinomas in patients with a history of surgery.
  • [MeSH-minor] Adult. Aged. Contrast Media. Diagnosis, Differential. Fluorodeoxyglucose F18. Humans. Hydronephrosis / etiology. Image Enhancement / methods. Liver / pathology. Liver / radionuclide imaging. Magnetic Resonance Imaging. Male. Pelvis / pathology. Pelvis / radiography. Positron-Emission Tomography. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 19412522.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2672189
  • [Keywords] NOTNLM ; Colon, surgery / Foreign bodies / Granuloma
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18. Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L: 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet; 2009 Mar;46(3):168-75
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  • METHODS AND RESULTS: Using the array comparative genomic hybridisation (CGH), we identified five individuals with non-recurrent deletions of 20p12.3.

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  • (PMID = 18812404.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL091771-02; None / None / / R01 HL091771-01; United States / NHLBI NIH HHS / HL / R01 HL091771-01; United States / NIDCR NIH HHS / DE / R01 DE/HD 12324-12; None / None / / R01 HL091771-02; United States / NIDCR NIH HHS / DE / R01 DE012324; United States / NHLBI NIH HHS / HL / R01 HL091771
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / Bmp2 protein, mouse; 0 / Bone Morphogenetic Protein 2; 0 / Calcium-Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 134324-36-0 / Serrate proteins
  • [Other-IDs] NLM/ NIHMS94820; NLM/ PMC2680125
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19. Sibai B, Meis PJ, Klebanoff M, Dombrowski MP, Weiner SJ, Moawad AH, Northen A, Iams JD, Varner MW, Caritis SN, O'Sullivan MJ, Miodovnik M, Leveno KJ, Conway D, Wapner RJ, Carpenter M, Mercer B, Ramin SM, Thorp JM Jr, Peaceman AM, Gabbe S, Maternal Fetal Medicine Units Network of the National Institute of Child Health and Human Development: Plasma CRH measurement at 16 to 20 weeks' gestation does not predict preterm delivery in women at high-risk for preterm delivery. Am J Obstet Gynecol; 2005 Sep;193(3 Pt 2):1181-6
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  • STUDY DESIGN: This is an analysis of data from a multicenter placebo-controlled trial designed to evaluate the role of 17 alpha hydroxyprogesterone caproate (17P) in the prevention of recurrent preterm birth.
  • CONCLUSION: A single measurement of corticotropin-releasing hormone at 16 to 20 weeks' gestation is not a good biomarker for recurrent preterm delivery in patients at high risk for this complication.
  • [MeSH-minor] Adult. Female. Humans. Predictive Value of Tests. Pregnancy. Pregnancy Trimester, Second

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  • (PMID = 16157134.001).
  • [ISSN] 0002-9378
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD21410; United States / NICHD NIH HHS / HD / HD21414; United States / NICHD NIH HHS / HD / HD27860; United States / NICHD NIH HHS / HD / HD27861; United States / NICHD NIH HHS / HD / HD27869; United States / NICHD NIH HHS / HD / HD27905; United States / NICHD NIH HHS / HD / HD27915; United States / NICHD NIH HHS / HD / HD27917; United States / NICHD NIH HHS / HD / HD34116; United States / NICHD NIH HHS / HD / HD34122; United States / NICHD NIH HHS / HD / HD34136; United States / NICHD NIH HHS / HD / HD34208; United States / NICHD NIH HHS / HD / HD34210; United States / NICHD NIH HHS / HD / HD36801; United States / NICHD NIH HHS / HD / HD40500; United States / NICHD NIH HHS / HD / HD40512; United States / NICHD NIH HHS / HD / HD40544; United States / NICHD NIH HHS / HD / HD40560
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 9015-71-8 / Corticotropin-Releasing Hormone
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20. Bumbasirević M, Tomić S, Lesić A, Milosević I, Atkinson HD: War-related infected tibial nonunion with bone and soft-tissue loss treated with bone transport using the Ilizarov method. Arch Orthop Trauma Surg; 2010 Jun;130(6):739-49
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  • Over a mean follow-up of 99 months no patient refractured their reconstruction, developed any symptoms or signs of recurrent infection, or required amputation.
  • [MeSH-minor] Adult. Female. Fracture Healing / physiology. Humans. Limb Salvage / methods. Male. Retrospective Studies. Soft Tissue Injuries / surgery. Warfare. Young Adult. Yugoslavia

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  • (PMID = 19946693.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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21. Wang RY, Jones JR, Chen S, Rogers RC, Friez MJ, Schwartz CE, Graham JM Jr: A previously unreported mutation in a Currarino syndrome kindred. Am J Med Genet A; 2006 Sep 15;140(18):1923-30
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  • Sacral malformation, presacral mass, and anorectal malformations comprise the classic triad, but other common symptoms and malformations include neonatal-onset bowel obstruction, chronic constipation, recurrent perianal sepsis, renal/urinary tract anomalies, female internal genital anomalies, tethered spinal cord, and anterior meningocele.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Humans. Infant. Middle Aged. Pedigree. Syndrome

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  • (PMID = 16906559.001).
  • [ISSN] 1552-4825
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM08243; United States / NICHD NIH HHS / HD / HD22657-11
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / MNX1 protein, human; 0 / Transcription Factors
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22. Connell CM, Vanderploeg JJ, Katz KH, Caron C, Saunders L, Tebes JK: Maltreatment following reunification: predictors of subsequent Child Protective Services contact after children return home. Child Abuse Negl; 2009 Apr;33(4):218-28
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  • Child neglect was the primary type of recurrent maltreatment that occurred following reunification.
  • PRACTICE IMPLICATIONS: This study suggests that services should be developed to minimize the risk for recurrent maltreatment following reunification.
  • [MeSH-minor] Adolescent. Child. Child Welfare. Child, Preschool. Family Characteristics. Family Relations. Female. Humans. Infant. Male. Proportional Hazards Models. Recurrence. Rhode Island. Risk Assessment. Young Adult

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  • [Cites] Child Abuse Negl. 1999 Dec;23(12):1359-70 [10626617.001]
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  • (PMID = 19327834.001).
  • [ISSN] 1873-7757
  • [Journal-full-title] Child abuse & neglect
  • [ISO-abbreviation] Child Abuse Negl
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / L30 HD045222; United States / NIDA NIH HHS / DA / T32 DA019426
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS523444; NLM/ PMC3867131
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23. Tita AT, Cliver SP, Goepfert AR, Conner M, Goldenberg RL, Hauth JC, Andrews WW: Impact of interconception antibiotics on the endometrial microbial flora. Am J Obstet Gynecol; 2007 Mar;196(3):226.e1-6
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  • STUDY DESIGN: This was a secondary analysis of a double-blind randomized placebo-controlled trial of prophylactic metronidazole plus azithromycin that was given to 241 women (antibiotics, 118 women; placebo, 123 women) with a previous preterm delivery to prevent recurrent preterm delivery.

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  • (PMID = 17346530.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD33883; United States / NICHD NIH HHS / HD / R01 HD033883-04; United States / NICHD NIH HHS / HD / R01 HD033883-05
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 140QMO216E / Metronidazole; 83905-01-5 / Azithromycin
  • [Other-IDs] NLM/ NIHMS19732; NLM/ PMC1857329
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24. Stryjewski ME, Szczech LA, Benjamin DK Jr, Inrig JK, Kanafani ZA, Engemann JJ, Chu VH, Joyce MJ, Reller LB, Corey GR, Fowler VG Jr: Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis; 2007 Jan 15;44(2):190-6
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  • Treatment failure (defined as death or recurrent infection) was determined at 12 weeks after the initial positive blood culture results.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Microbial Sensitivity Tests. Middle Aged. Odds Ratio. Renal Dialysis. Risk Factors. Staphylococcus aureus / drug effects. Treatment Failure

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  • [CommentIn] Clin Infect Dis. 2015 Apr 15;60(8):1290-1 [25609683.001]
  • [CommentIn] Clin Infect Dis. 2015 Apr 15;60(8):1291-2 [25609681.001]
  • (PMID = 17173215.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI 059111; United States / NICHD NIH HHS / HD / HD-044799-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 6Q205EH1VU / Vancomycin; IHS69L0Y4T / Cefazolin
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25. Busse ME, Wiles CM, Rosser AE: Mobility and falls in people with Huntington's disease. J Neurol Neurosurg Psychiatry; 2009 Jan;80(1):88-90
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  • [Title] Mobility and falls in people with Huntington's disease.
  • OBJECTIVE: The aim of this study was to estimate the frequency of falls in people with Huntington's disease (HD) and make a preliminary assessment of tools appropriate for assessing the risk of falling.
  • SUBJECTS: 24 people with HD.
  • Unified Huntington Disease Rating Scale (UHDRS) motor, Functional Assessment Scale (FAS), Independence Scale (IS) and Total Functional Capacity (TFC) scores were obtained as well as data about falls and stumbles.
  • Differences between "recurrent fallers" (>or=2 falls/year) and "non-fallers" (<or=1 fall/year) for the range of outcome measures were investigated and probabilities calculated.
  • RESULTS: Mean (SD) age (years) of people with HD (n = 24) tested was 56.6 (11.7) and BMI (kg/m(2)) 24.7 (5.5).
  • Recurrent fallers walked less (p<0.01) and slower than non-fallers.
  • People with HD had increased risk of falls if TUG scores were >or=14 s or BBS scores <or=40.
  • CONCLUSION: A high proportion of HD patients have recurrent falls, and the BBS and TUG appear to be useful in falls risk assessment.
  • [MeSH-major] Accidental Falls / statistics & numerical data. Huntington Disease / epidemiology. Huntington Disease / physiopathology. Motor Activity
  • [MeSH-minor] Adult. Aged. Disability Evaluation. Female. Humans. Logistic Models. Male. Middle Aged. Postural Balance. Risk Factors

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  • (PMID = 19091714.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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26. Litonjua AA, Rifas-Shiman SL, Ly NP, Tantisira KG, Rich-Edwards JW, Camargo CA Jr, Weiss ST, Gillman MW, Gold DR: Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutr; 2006 Oct;84(4):903-11
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  • The outcomes of interest were any wheezing by the child during either the first or second year of life, recurrent wheezing in both years, and eczema in either the first or second year.
  • Similar results were obtained for recurrent wheezing at 2 y of age with vitamin E (OR: 0.49; 95% CI: 0.27, 0.90) and zinc (OR: 0.49; 95% CI: 0.27, 0.87) (P for trend = 0.05 and 0.06 over quartiles of intake for vitamin E and zinc, respectively).

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  • (PMID = 17023719.001).
  • [ISSN] 0002-9165
  • [Journal-full-title] The American journal of clinical nutrition
  • [ISO-abbreviation] Am. J. Clin. Nutr.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD34568; United States / NIAID NIH HHS / AI / R01 AI035786; United States / NICHD NIH HHS / HD / R37 HD034568; United States / NHLBI NIH HHS / HL / R01 HL064925; United States / NHLBI NIH HHS / HL / R01 HL061907; United States / NHLBI NIH HHS / HL / HL61907; United States / NHLBI NIH HHS / HL / HL068041-03; United States / NHLBI NIH HHS / HL / R01 HL064925-03; United States / NICHD NIH HHS / HD / HD034568-03; United States / NHLBI NIH HHS / HL / K24 HL068041-03; United States / NHLBI NIH HHS / HL / HL64925; United States / NHLBI NIH HHS / HL / K24 HL068041; United States / NHLBI NIH HHS / HL / R01 HL061907-03; United States / NHLBI NIH HHS / HL / HL064925-03; United States / NIAID NIH HHS / AI / AI35786; United States / NHLBI NIH HHS / HL / HL061907-03; United States / NIAID NIH HHS / AI / R56 AI035786; United States / NICHD NIH HHS / HD / R01 HD034568; United States / NICHD NIH HHS / HD / R01 HD034568-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants
  • [Other-IDs] NLM/ NIHMS29415; NLM/ PMC1994925
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27. Tsui I, Schubert HD: Retinotomy and silicone oil for detachments complicated by anterior inferior proliferative vitreoretinopathy. Br J Ophthalmol; 2009 Sep;93(9):1228-33
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  • AIM: To describe a subset of patients with recurrent retinal detachments caused by anterior intraretinal and subretinal proliferative vitreoretinopathy (PVR), which required greater than 180 degrees retinotomy and silicone oil tamponade.
  • Main outcomes included change in visual acuity, recurrent detachment and postoperative complications.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Secondary Prevention. Treatment Outcome. Visual Acuity / physiology. Vitrectomy / adverse effects. Young Adult

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  • (PMID = 19429589.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Silicone Oils
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28. Clark RD, Graham JM Jr, Friez MJ, Hoo JJ, Jones KL, McKeown C, Moeschler JB, Raymond FL, Rogers RC, Schwartz CE, Battaglia A, Lyons MJ, Stevenson RE: FG syndrome, an X-linked multiple congenital anomaly syndrome: the clinical phenotype and an algorithm for diagnostic testing. Genet Med; 2009 Nov;11(11):769-75
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  • This algorithm can assist the clinician in selecting the patients for testing who are most likely to have the recurrent p.R961W MED12 mutation.

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  • (PMID = 19938245.001).
  • [ISSN] 1530-0366
  • [Journal-full-title] Genetics in medicine : official journal of the American College of Medical Genetics
  • [ISO-abbreviation] Genet. Med.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / P01 HD022657; United States / NICHD NIH HHS / HD / HD22657; United States / NIGMS NIH HHS / GM / T32 GM008243; United States / NICHD NIH HHS / HD / R01 HD026202; United States / NIGMS NIH HHS / GM / 5-T32-GM08243; United States / NICHD NIH HHS / HD / HD26202
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MED12 protein, human; 0 / Mediator Complex
  • [Other-IDs] NLM/ NIHMS598898; NLM/ PMC4113033
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29. Cooper LT Jr, Hare JM, Tazelaar HD, Edwards WD, Starling RC, Deng MC, Menon S, Mullen GM, Jaski B, Bailey KR, Cunningham MW, Dec GW, Giant Cell Myocarditis Treatment Trial Investigators: Usefulness of immunosuppression for giant cell myocarditis. Am J Cardiol; 2008 Dec 1;102(11):1535-9
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  • Her case demonstrates for the first time that there is a risk of recurrent, sometimes fatal, GCM after cessation of immunosuppression.

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  • (PMID = 19026310.001).
  • [ISSN] 1879-1913
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] ENG
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00027443
  • [Grant] United States / NHLBI NIH HHS / HL / HL074877-01A1; United States / FDA HHS / FD / FD-RO-1-001986; United States / NHLBI NIH HHS / HL / R13 HL074877-01A1
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Muromonab-CD3; 83HN0GTJ6D / Cyclosporine; MRK240IY2L / Azathioprine
  • [Other-IDs] NLM/ NIHMS80786; NLM/ PMC2613862
  • [Investigator] Cooper LT Jr; Menon S; Deng M; Mullin G; Starling R; Jaski B; Bourge R; Dec G; Hare J; Kao A; Leier C; Wagoner L; Zucker M; Skopecki H; Murali S; Mendez J; Caforio A; Rodeheffer R; Mason JW; Ballman KV; Gersh BJ; Tazelaar HD; Edwards WD
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30. Barnes TW, Vassallo R, Tazelaar HD, Hartman TE, Ryu JH: Diffuse bronchiolar disease due to chronic occult aspiration. Mayo Clin Proc; 2006 Feb;81(2):172-6
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  • [Title] Diffuse bronchiolar disease due to chronic occult aspiration.
  • OBJECTIVE: To describe clinical, radiological, and histopathologic features of diffuse bronchiolar disease due to chronic occult aspiration.
  • PATIENTS AND METHODS: We identified 4 patients encountered from July 2001 to January 2004 who had persistent respiratory symptoms and lung Infiltrates and who were eventually diagnosed by surgical lung biopsy as having diffuse bronchiolar disease due to chronic occult aspiration.
  • CONCLUSION: Diffuse bronchiolar disease likely represents an underrecognized form of aspiration-related lung disease and may occur in relatively young Individuals without symptoms suggestive of recurrent aspiration.
  • [MeSH-minor] Adult. Female. Gastroesophageal Reflux / complications. Humans. Male. Middle Aged

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  • (PMID = 16471070.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Owen J, Hankins G, Iams JD, Berghella V, Sheffield JS, Perez-Delboy A, Egerman RS, Wing DA, Tomlinson M, Silver R, Ramin SM, Guzman ER, Gordon M, How HY, Knudtson EJ, Szychowski JM, Cliver S, Hauth JC: Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length. Am J Obstet Gynecol; 2009 Oct;201(4):375.e1-8
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  • OBJECTIVE: The objective of the study was to assess cerclage to prevent recurrent preterm birth in women with short cervix.


32. Hill C, McKinney E, Lowndes CM, Munro H, Murphy G, Parry JV, Gill ON, GUM Anon Network: Epidemiology of herpes simplex virus types 2 and 1 amongst men who have sex with men attending sexual health clinics in England and Wales: implications for HIV prevention and management. Euro Surveill; 2009;14(47)
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  • Four of the twelve attendees who received a diagnosis of recurrent anogenital herpes at the clinic visit were HSV-1-seropositive but not HSV-2-seropositive at the time, although no cultures or PCR results were available to type the cause of the ano-genital presenting disease.
  • [MeSH-minor] Adult. Ambulatory Care Facilities / utilization. Antibodies, Viral / blood. Comorbidity. Emigrants and Immigrants / statistics & numerical data. England / epidemiology. HIV Antibodies / blood. HIV Seroprevalence. Humans. Male. Middle Aged. Prevalence. Seroepidemiologic Studies. Sexually Transmitted Diseases / epidemiology. Wales / epidemiology. Young Adult

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  • (PMID = 19941804.001).
  • [ISSN] 1560-7917
  • [Journal-full-title] Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin
  • [ISO-abbreviation] Euro Surveill.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / HIV Antibodies
  • [Investigator] Mercey D; Sullivan A; Carne C; Carey PB; Birley HD; Lawton M; Maw R; Ross J; McManus T; Kinghorn G; Sankar KN; Tenant-Flowers M; Murphjy S; Nathan PM; Greene L; Hay P; Scott G; Almeida M; Jalal H; Rothburn M; Jones R; Coyle P; Osman H; Wilson P; Kudesia G; Magee J; Zuckerman M; Shafi S; Claxton A; Muir D; Rice P
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33. Bakoush O, Ohlin AK, Strandberg K, Kurkus J: Low plasma activated protein C-protein C inhibitor complex concentration is associated with vascular access failure in hemodialysis patients. Nephron Clin Pract; 2008;110(3):c151-7
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  • BACKGROUND: Vascular access failure is a common cause of morbidity in patients with end-stage renal failure on hemodialysis (HD).
  • Activation of the coagulation system and formation of a thrombus play important roles in recurrent arteriovenous fistula/graft (AVFG) failure.
  • METHODS: Thirty-five HD patients dialyzed through a functioning AVFG were studied.
  • Blood was drawn before and after the HD session for the analysis of the APC-PCI complex, soluble TM concentration and activity, von Willebrand factor antigen and homocysteine.
  • CONCLUSION: Thus, a low level of P-APC-PCI complex may be associated with an increased risk of AVFG failure in HD patients.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blood Vessel Prosthesis Implantation / adverse effects. Female. Humans. Male. Middle Aged. Prognosis. Renal Dialysis. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18953177.001).
  • [ISSN] 1660-2110
  • [Journal-full-title] Nephron. Clinical practice
  • [ISO-abbreviation] Nephron Clin Pract
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Protein C; 0 / Protein C Inhibitor
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34. Meis PJ, Klebanoff M, Dombrowski MP, Sibai BM, Leindecker S, Moawad AH, Northen A, Iams JD, Varner MW, Caritis SN, O'Sullivan MJ, Miodovnik M, Leveno KJ, Conway D, Wapner RJ, Carpenter M, Mercer B, Ramin SM, Thorp JM, Peaceman AM, Gabbe S: Does progesterone treatment influence risk factors for recurrent preterm delivery? Obstet Gynecol; 2005 Sep;106(3):557-61
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  • [Title] Does progesterone treatment influence risk factors for recurrent preterm delivery?
  • OBJECTIVE: To examine how demographic and pregnancy characteristics can affect the risk of recurrent preterm delivery and the how the effectiveness of progesterone treatment for prevention alters these relationships.
  • METHODS: This was a secondary analysis of a randomized trial of 17alpha-hydroxyprogesterone caproate to prevent recurrent preterm delivery in women at risk.
  • CONCLUSION: The use of 17alpha-hydroxyprogesterone caproate in women with a previous preterm delivery reduces the overall risk of preterm delivery and changes the epidemiology of risk factors for recurrent preterm delivery.
  • [MeSH-minor] Adult. Female. Humans. Multivariate Analysis. Pregnancy. Recurrence. Risk Factors

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  • (PMID = 16135587.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD21410; United States / NICHD NIH HHS / HD / HD21414; United States / NICHD NIH HHS / HD / HD27860; United States / NICHD NIH HHS / HD / HD27861; United States / NICHD NIH HHS / HD / HD27869; United States / NICHD NIH HHS / HD / HD27905; United States / NICHD NIH HHS / HD / HD27915; United States / NICHD NIH HHS / HD / HD27917; United States / NICHD NIH HHS / HD / HD34116; United States / NICHD NIH HHS / HD / HD34122; United States / NICHD NIH HHS / HD / HD34136; United States / NICHD NIH HHS / HD / HD34208; United States / NICHD NIH HHS / HD / HD34210; United States / NICHD NIH HHS / HD / HD36801; United States / NICHD NIH HHS / HD / HD40500; United States / NICHD NIH HHS / HD / HD40512; United States / NICHD NIH HHS / HD / HD40544; United States / NICHD NIH HHS / HD / HD40560; United States / NCRR NIH HHS / RR / M01-RR-000080
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydroxyprogesterones; 0 / Progestins; 276F2O42F5 / 17-alpha-hydroxy-progesterone caproate
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35. Sahin S, Sahin GM, Ergin H, Kantarci G: The effect of dialytic modalities on clinical outcomes in ESRD patients with familial Mediterranean fever. Ren Fail; 2007;29(3):315-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Familial Mediterranean fever (FMF) is an autosomal recessive disease seen primarily in Sephardic Jews, Turks, and Armenians.
  • The disease manifests as recurrent attacks of fever and serositis.
  • As a result, the best treatment modality of end-stage renal disease (ESRD) in these circumstances still remains unclear.
  • All 40 patients were on renal replacement therapy, 20 on hemodialysis (HD), 20 on peritoneal dialysis (PD).
  • [MeSH-minor] Adult. Biomarkers / blood. Blood Pressure. Creatinine / blood. Dialysis Solutions. Erythropoietin / therapeutic use. Female. Follow-Up Studies. Humans. Male. Recombinant Proteins. Research Design. Retrospective Studies. Surveys and Questionnaires. Treatment Outcome. Turkey. Weight Gain

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  • (PMID = 17497446.001).
  • [ISSN] 0886-022X
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Dialysis Solutions; 0 / Recombinant Proteins; 11096-26-7 / Erythropoietin; AYI8EX34EU / Creatinine
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36. Kuo MC, Chang JM, Tsai JC, Chen HC, Tsai WC, Lai YH, Hwang SJ: Decreased B cells and IgA-secreting B cells partially explain the high prevalence of IgA deficiency in dialysis patients. Clin Nephrol; 2006 Oct;66(4):240-6
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  • AIMS: We previously reported 2 hemodialysis (HD) patients with recurrent infections and selective immunoglobulin A deficiency (IgAD).
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphocyte Count. Male. Middle Aged. Prevalence

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  • (PMID = 17063990.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunoglobulin A
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37. Yost NP, Owen J, Berghella V, Thom E, Swain M, Dildy GA 3rd, Miodovnik M, Langer O, Sibai B, National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network: Effect of coitus on recurrent preterm birth. Obstet Gynecol; 2006 Apr;107(4):793-7
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  • [Title] Effect of coitus on recurrent preterm birth.
  • OBJECTIVE: To estimate the impact of sexual behavior on the risk of recurrent spontaneous preterm birth at less than 37 weeks of gestation.
  • METHODS: This is a secondary analysis of a multicenter, blinded observational study of endovaginal sonographic examinations performed at 16-18 weeks of gestation on 187 women with singleton gestations who were at high risk for recurrent spontaneous preterm birth (prior spontaneous preterm birth at < 32 weeks of gestation).
  • Women who reported infrequent sexual intercourse during early pregnancy had an incidence of recurrent spontaneous preterm birth of 28% compared with 38% in those women who reported some intercourse (P = .35).
  • CONCLUSION: Self-reported coitus during early pregnancy was not associated with an increased risk of recurrent preterm delivery.
  • There was an association between increasing number of sexual partners in a woman's lifetime and recurrent preterm delivery.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Double-Blind Method. Female. Gestational Age. Humans. Incidence. Logistic Models. Maternal Age. Parity. Pregnancy. Probability. Risk Assessment. Statistics, Nonparametric

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  • (PMID = 16582114.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD21414; United States / NICHD NIH HHS / HD / HD27860; United States / NICHD NIH HHS / HD / HD27869; United States / NICHD NIH HHS / HD / HD27905; United States / NICHD NIH HHS / HD / HD34116; United States / NICHD NIH HHS / HD / HD34136; United States / NICHD NIH HHS / HD / HD34208; United States / NICHD NIH HHS / HD / HD34210; United States / NICHD NIH HHS / HD / HD36801
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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38. Wagner TD, Kobayashi W, Dean S, Goldberg SI, Kirsch DG, Suit HD, Hornicek FJ, Pedlow FX, Raskin KA, Springfield DS, Yoon SS, Gebhardt MC, Mankin HJ, Delaney TF: Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone. Int J Radiat Oncol Biol Phys; 2009 Jan 1;73(1):259-66
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  • With 31.8-month median follow-up, the 5-year overall survival (OS) rate is 65%; 5-year disease-free survival (DFS) rate, 53.8%; and 5-year local control (LC) rate, 72%.
  • Between primary and recurrent disease, there was no significant difference in OS rates (74.4% vs. 51.4%, respectively; p = 0.128), in contrast to DFS (71.5% vs. 18.3%; p = 0.0014) and LC rates (88.9% vs. 30.9%; p = 0.0011) favoring primary disease.
  • The LC and DFS rates are substantially better for patients with primary than recurrent sarcomas.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Dose Fractionation. Feasibility Studies. Humans. Middle Aged. Postoperative Care. Preoperative Care. Radiotherapy, Adjuvant. Treatment Outcome. Young Adult

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  • (PMID = 19100921.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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39. Iams JD, Berghella V: Care for women with prior preterm birth. Am J Obstet Gynecol; 2010 Aug;203(2):89-100
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  • African American women have rates of recurrent preterm birth that are nearly twice that of women of other backgrounds.
  • An approximate risk of recurrent preterm birth can be estimated by a comprehensive reproductive history, with emphasis on maternal race, the number and gestational age of prior births, and the sequence of events preceding the index preterm birth.
  • Interventions including smoking cessation, eradication of asymptomatic bacteriuria, progestational agents, and cervical cerclage can reduce the risk of recurrent preterm birth when employed appropriately.
  • [MeSH-minor] Adult. African Americans / statistics & numerical data. European Continental Ancestry Group / statistics & numerical data. Female. Gestational Age. Humans. Incidence. Infant, Newborn. Maternal Welfare. Pregnancy. Primary Prevention / methods. Prognosis. Recurrence. Risk Assessment. Young Adult

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
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  • (PMID = 20417491.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / U10 HD027915; United States / NCRR NIH HHS / RR / UL1 RR025755
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 112
  • [Other-IDs] NLM/ NIHMS448175; NLM/ PMC3648852
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40. Sharp AJ, Selzer RR, Veltman JA, Gimelli S, Gimelli G, Striano P, Coppola A, Regan R, Price SM, Knoers NV, Eis PS, Brunner HG, Hennekam RC, Knight SJ, de Vries BB, Zuffardi O, Eichler EE: Characterization of a recurrent 15q24 microdeletion syndrome. Hum Mol Genet; 2007 Mar 1;16(5):567-72
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  • [Title] Characterization of a recurrent 15q24 microdeletion syndrome.
  • Our results define microdeletion of 15q24 as a novel recurrent genomic disorder.
  • [MeSH-minor] Adolescent. Adult. Base Sequence. Chromosome Breakage. DNA Mutational Analysis. Humans. Male. Molecular Sequence Data. Oligonucleotide Array Sequence Analysis. Syndrome


41. Cassidy HD, Cassidy LA, Blackshear JL: Incidental discovery of a patent ductus arteriosus in adults. J Am Board Fam Med; 2009 Mar-Apr;22(2):214-8
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  • Patent ductus arteriosus (PDA) is an uncommon clinical finding in adult primary care patients.
  • The clinical spectrum of presentation of a PDA may range from a "silent" PDA, one with no clinical manifestations but which is incidentally discovered on echocardiogram for other purposes, to patients who present with congestive heart failure, pulmonary hypertension, signs of volume overload, endocarditis, atrial fibrillation, or "recurrent pneumonia."
  • We describe 2 cases that illustrate the discovery of an asymptomatic PDA during routine physical examination of adult patients.

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  • (PMID = 19264947.001).
  • [ISSN] 1557-2625
  • [Journal-full-title] Journal of the American Board of Family Medicine : JABFM
  • [ISO-abbreviation] J Am Board Fam Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Graham JM Jr, Visootsak J, Dykens E, Huddleston L, Clark RD, Jones KL, Moeschler JB, Opitz JM, Morford J, Simensen R, Rogers RC, Schwartz CE, Friez MJ, Stevenson RE: Behavior of 10 patients with FG syndrome (Opitz-Kaveggia syndrome) and the p.R961W mutation in the MED12 gene. Am J Med Genet A; 2008 Dec 1;146A(23):3011-7
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  • We also characterize the behavior of eight additional individuals with FG syndrome and this recurrent mutation in MED12 using the Vineland Adaptive Behavior Scales 2nd edition, the Reiss Profile of Fundamental Goals and Motivation Sensitivities, and the Achenbach Child Behavior Checklist.
  • Based on the behavior phenotype in 10 males with this recurrent MED12 mutation, we offer specific recommendations and interventional strategies.

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  • [Copyright] Copyright (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18973276.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00425; United States / NICHD NIH HHS / HD / P01 HD022657; United States / NICHD NIH HHS / HD / P01 HD022657-12; United States / NCRR NIH HHS / RR / K12 RR025009,; United States / NICHD NIH HHS / HD / HD22657; United States / NCRR NIH HHS / RR / KL2 RR025009; United States / NIGMS NIH HHS / GM / T32 GM008243; United States / NCATS NIH HHS / TR / UL1 TR000454; United States / NICHD NIH HHS / HD / R01 HD026202; United States / NIGMS NIH HHS / GM / 5-T32-GM08243; United States / NCRR NIH HHS / RR / M01 RR000425; United States / NIMHD NIH HHS / MD / L32 MD000625; United States / NICHD NIH HHS / HD / HD262020
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MED12 protein, human; 0 / Mediator Complex; 0 / Receptors, Thyroid Hormone; 8DUH1N11BX / Tryptophan; 94ZLA3W45F / Arginine
  • [Other-IDs] NLM/ NIHMS76047; NLM/ PMC3092600
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43. Lange NE, Rifas-Shiman SL, Camargo CA Jr, Gold DR, Gillman MW, Litonjua AA: Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children. J Allergy Clin Immunol; 2010 Aug;126(2):250-5, 255.e1-4
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  • [Title] Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children.
  • OBJECTIVE: To determine whether overall maternal dietary pattern during pregnancy is associated with recurrent wheeze in children.
  • Multivariable logistic regression was used to look at associations between dietary pattern and the primary outcome of recurrent wheeze at 3 years.
  • RESULTS: None of these dietary patterns was associated with the primary outcome of recurrent wheeze in children in either the crude or the multivariable model (multivariable model, odds ratio per 1-point increase in Mediterranean diet, 0.98 [95% CI, 0.89-1.08]; AHEI-P, 1.07 [0.87-1.30]; Prudent, 1.02 [0.83-1.26]; Western, 0.98 [0.81-1.19]).
  • CONCLUSION: Overall dietary pattern during pregnancy is not associated with recurrent wheeze in this cohort.

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  • [Copyright] Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20584543.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL064925-09; United States / NICHD NIH HHS / HD / HD034568-09; United States / NIAID NIH HHS / AI / R01 AI035786-17; United States / NICHD NIH HHS / HD / HD34568; United States / NHLBI NIH HHS / HL / K24 HL068041-09; United States / NIAID NIH HHS / AI / R01 AI035786; United States / NICHD NIH HHS / HD / R37 HD034568; United States / NHLBI NIH HHS / HL / R01 HL064925; United States / NHLBI NIH HHS / HL / HL68041; United States / NHLBI NIH HHS / HL / HL61907; None / None / / K24 HL068041-09; United States / NIAID NIH HHS / AI / AI035786-17; United States / NHLBI NIH HHS / HL / HL007427; United States / NHLBI NIH HHS / HL / HL007427-30; United States / NHLBI NIH HHS / HL / HL64925; United States / NHLBI NIH HHS / HL / K24 HL068041; United States / NIAID NIH HHS / AI / AI35786; United States / NICHD NIH HHS / HD / R01 HD034568-09; United States / NIAID NIH HHS / AI / R56 AI035786; United States / NICHD NIH HHS / HD / R01 HD034568; United States / NHLBI NIH HHS / HL / R01 HL064925-09; United States / NHLBI NIH HHS / HL / T32 HL007427; United States / NHLBI NIH HHS / HL / T32 HL007427-30
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS218235; NLM/ PMC2917539
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44. Gammill HS, Powers RW, Clifton RG, Van Dorsten JP, Klebanoff MA, Lindheimer MD, Sibai B, Landon MB, Miodovnik M, Dombrowski M, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, MD: Does C-reactive protein predict recurrent preeclampsia? Hypertens Pregnancy; 2010;29(4):399-409
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  • [Title] Does C-reactive protein predict recurrent preeclampsia?
  • OBJECTIVE: Evaluate association of the inflammatory marker C-reactive protein with recurrent preeclampsia.
  • CONCLUSION: In this group of women with previous preeclampsia, neither baseline C-reactive protein concentration nor change in concentration over gestation was associated with recurrent preeclampsia.

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  • (PMID = 20701468.001).
  • [ISSN] 1525-6065
  • [Journal-full-title] Hypertension in pregnancy
  • [ISO-abbreviation] Hypertens Pregnancy
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / U10 HD021414-15; United States / NICHD NIH HHS / HD / HD36801; United States / NICHD NIH HHS / HD / HD27861; United States / NICHD NIH HHS / HD / UG1 HD027869; United States / NICHD NIH HHS / HD / HD27905; United States / NICHD NIH HHS / HD / U10 HD036801-15; United States / NICHD NIH HHS / HD / P01 HD030367; United States / NICHD NIH HHS / HD / U10 HD027861-10; United States / NICHD NIH HHS / HD / HD27883; United States / NICHD NIH HHS / HD / HD27869; United States / NICHD NIH HHS / HD / HD27860; United States / NICHD NIH HHS / HD / UG1 HD027915; United States / NICHD NIH HHS / HD / HD21414; United States / NICHD NIH HHS / HD / U10 HD027905; United States / NICHD NIH HHS / HD / U10 HD021410-29; United States / NICHD NIH HHS / HD / U10 HD027883-06; United States / NICHD NIH HHS / HD / U10 HD027905-10; United States / NICHD NIH HHS / HD / U10 HD027915-23; United States / NICHD NIH HHS / HD / U10 HD027883; United States / NICHD NIH HHS / HD / HD030367-18; United States / NICHD NIH HHS / HD / U10 HD027917-24; United States / NICHD NIH HHS / HD / HD21410; United States / NICHD NIH HHS / HD / U10 HD027869; United States / NICHD NIH HHS / HD / U10 HD027869-24; United States / NICHD NIH HHS / HD / U10 HD027917; United States / NICHD NIH HHS / HD / P01 HD030367-18; United States / NICHD NIH HHS / HD / U10 HD027915; United States / NICHD NIH HHS / HD / HD19897; United States / NICHD NIH HHS / HD / U10 HD027860; United States / NICHD NIH HHS / HD / HD27889; United States / NICHD NIH HHS / HD / U01 HD019897; United States / NICHD NIH HHS / HD / 2P01-HD30367; United States / NICHD NIH HHS / HD / HD27915; United States / NICHD NIH HHS / HD / U10 HD027860-15; United States / NICHD NIH HHS / HD / HD27917; United States / NICHD NIH HHS / HD / U10 HD021410; United States / NICHD NIH HHS / HD / U10 HD036801; United States / NICHD NIH HHS / HD / HD21434; United States / NICHD NIH HHS / HD / U01 HD036801; United States / NICHD NIH HHS / HD / HD027883-06
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 9007-41-4 / C-Reactive Protein
  • [Other-IDs] NLM/ NIHMS366726; NLM/ PMC3339658
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45. Girirajan S, Rosenfeld JA, Cooper GM, Antonacci F, Siswara P, Itsara A, Vives L, Walsh T, McCarthy SE, Baker C, Mefford HC, Kidd JM, Browning SR, Browning BL, Dickel DE, Levy DL, Ballif BC, Platky K, Farber DM, Gowans GC, Wetherbee JJ, Asamoah A, Weaver DD, Mark PR, Dickerson J, Garg BP, Ellingwood SA, Smith R, Banks VC, Smith W, McDonald MT, Hoo JJ, French BN, Hudson C, Johnson JP, Ozmore JR, Moeschler JB, Surti U, Escobar LF, El-Khechen D, Gorski JL, Kussmann J, Salbert B, Lacassie Y, Biser A, McDonald-McGinn DM, Zackai EH, Deardorff MA, Shaikh TH, Haan E, Friend KL, Fichera M, Romano C, Gécz J, DeLisi LE, Sebat J, King MC, Shaffer LG, Eichler EE: A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Nat Genet; 2010 Mar;42(3):203-9
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  • [Title] A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay.
  • We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay.
  • Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease.
  • [MeSH-minor] Adult. Case-Control Studies. Child. Child, Preschool. Comparative Genomic Hybridization / methods. Family. Gene Frequency. Humans. Infant. Oligonucleotide Array Sequence Analysis. Pedigree. Phenotype. Polymorphism, Single Nucleotide. Recurrence. Severity of Illness Index


51. Shih ML, Lee JA, Hsieh CB, Yu JC, Liu HD, Kebebew E, Clark OH, Duh QY: Thyroidectomy for Hashimoto's thyroiditis: complications and associated cancers. Thyroid; 2008 Jul;18(7):729-34
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  • One hundred and fifty-two patients (32.1%) had transient postoperative hypocalcemia, 2 (0.4%) had transient recurrent nerve palsy, and 4 (0.8%) had a postoperative neck hematoma.
  • [MeSH-major] Hashimoto Disease / surgery. Postoperative Complications. Thyroidectomy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Hypocalcemia / etiology. Male. Middle Aged. Retrospective Studies. Thyroid Neoplasms / etiology. Treatment Outcome. Vocal Cord Paralysis / etiology

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  • (PMID = 18631001.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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52. Hong WJ, Kim WK, Park CW, Lee SG, Yoo CJ, Kim YB, Jho HD: Comparison between transuncal approach and upper vertebral transcorporeal approach for unilateral cervical radiculopathy - a preliminary report. Minim Invasive Neurosurg; 2006 Oct;49(5):296-301
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  • In the TU approach, 28 patients experienced excellent results, 11 patients experienced good results, one patient who experienced a fair result was operated by anterior cervical fusion because of a recurrent herniated disc.
  • [MeSH-minor] Activities of Daily Living. Adult. Female. Humans. Length of Stay. Male. Microsurgery / methods. Middle Aged. Patient Satisfaction. Postoperative Complications / prevention & control. Spinal Nerve Roots / surgery. Treatment Outcome

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  • (PMID = 17163344.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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53. Sheridan MB, Kato T, Haldeman-Englert C, Jalali GR, Milunsky JM, Zou Y, Klaes R, Gimelli G, Gimelli S, Gemmill RM, Drabkin HA, Hacker AM, Brown J, Tomkins D, Shaikh TH, Kurahashi H, Zackai EH, Emanuel BS: A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: the t(8;22)(q24.13;q11.21). Am J Hum Genet; 2010 Aug 13;87(2):209-18
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  • [Title] A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: the t(8;22)(q24.13;q11.21).
  • Palindrome-mediated genomic instability has been associated with chromosomal translocations, including the recurrent t(11;22)(q23;q11).
  • We report a syndrome characterized by extremity anomalies, mild dysmorphia, and intellectual impairment caused by 3:1 meiotic segregation of a previously unrecognized recurrent palindrome-mediated rearrangement, the t(8;22)(q24.13;q11.21).

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  • (PMID = 20673865.001).
  • [ISSN] 1537-6605
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / P30 HD026979; United States / NCI NIH HHS / CA / R01 CA039926; United States / NCI NIH HHS / CA / CA39926; United States / NICHD NIH HHS / HD / HD26979
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2917714
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54. Mercer BM, Macpherson CA, Goldenberg RL, Goepfert AR, Hauguel-de Mouzon S, Varner MW, Iams JD, Meis PJ, Moawad AH, Miodovnik M, Caritis SN, Van Dorsten JP, Sorokin Y, Thurnau GR, Spong CY, NICHD Maternal-Fetal Medicine Units Network: Are women with recurrent spontaneous preterm births different from those without such history? Am J Obstet Gynecol; 2006 Apr;194(4):1176-84; discussion 1184-5
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  • [Title] Are women with recurrent spontaneous preterm births different from those without such history?
  • OBJECTIVE: This study was undertaken to determine whether women with recurrent spontaneous preterm births (rSPBs) have different clinical characteristics or systemic markers than those with isolated preterm (iSPBs) or recurrent term births (rTBs), when assessed remote from delivery.
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Recurrence

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  • [ErratumIn] Am J Obstet Gynecol. 2010 Nov;203(5):496. Haugel-De Mouzon, Sylvie [corrected to Hauguel-de Mouzon, Sylvie]
  • (PMID = 16580328.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD19897; United States / NICHD NIH HHS / HD / HD21410; United States / NICHD NIH HHS / HD / HD21414; United States / NICHD NIH HHS / HD / HD27860; United States / NICHD NIH HHS / HD / HD27861; United States / NICHD NIH HHS / HD / HD27869; United States / NICHD NIH HHS / HD / HD27883; United States / NICHD NIH HHS / HD / HD27905; United States / NICHD NIH HHS / HD / HD27915; United States / NICHD NIH HHS / HD / HD27917; United States / NICHD NIH HHS / HD / HD34208; United States / NICHD NIH HHS / HD / HD36801; United States / NICHD NIH HHS / HD / HD40544
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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55. Kemp AS, Fillmore PT, Lenjavi MR, Lyon M, Chicz-Demet A, Touchette PE, Sandman CA: Temporal patterns of self-injurious behavior correlate with stress hormone levels in the developmentally disabled. Psychiatry Res; 2008 Jan 15;157(1-3):181-9
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  • The current investigation employed a unique time-pattern analysis program (THEME) to examine whether recurrent temporal patterns (T-patterns) of SIB were related to morning levels of two POMC-derived hormones: beta-endorphin (betaE) and adrenocorticotropic hormone (ACTH).
  • These findings support the hypothesis that the recurrent temporal patterning of SIB represents a unique behavioral phenotype directly related to perturbed levels of POMC-derived stress hormones in certain individuals with severe DD.

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  • (PMID = 17913241.001).
  • [ISSN] 0165-1781
  • [Journal-full-title] Psychiatry research
  • [ISO-abbreviation] Psychiatry Res
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD31571; United States / NICHD NIH HHS / HD / HD048947-01A2; United States / NICHD NIH HHS / HD / HD048947-02; United States / NICHD NIH HHS / HD / R01 HD048947; United States / NICHD NIH HHS / HD / R01 HD048947-01A2; United States / NICHD NIH HHS / HD / R01 HD048947-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] 60617-12-1 / beta-Endorphin; 66796-54-1 / Pro-Opiomelanocortin; 9002-60-2 / Adrenocorticotropic Hormone
  • [Other-IDs] NLM/ NIHMS36021; NLM/ PMC2170430
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56. Emens J, Lewy AJ, Laurie AL, Songer JB: Rest-activity cycle and melatonin rhythm in blind free-runners have similar periods. J Biol Rhythms; 2010 Oct;25(5):381-4
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  • Such blind free-runners (BFRs) often attempt to maintain a 24-h sleep-wake schedule and consequently suffer from recurrent sleep disruption and daytime somnolence.
  • [MeSH-minor] Actigraphy. Adolescent. Adult. Aged. Biological Clocks / physiology. Child. Female. Humans. Male. Middle Aged. Photoperiod. Young Adult

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  • (PMID = 20876818.001).
  • [ISSN] 1552-4531
  • [Journal-full-title] Journal of biological rhythms
  • [ISO-abbreviation] J. Biol. Rhythms
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / K23RR017636; United States / NCRR NIH HHS / RR / M01 RR000334; United States / NIA NIH HHS / AG / R01 AG21826; United States / NEI NIH HHS / EY / R01 EY018312-09A1; United States / NICHD NIH HHS / HD / R01 HD42125; United States / NCRR NIH HHS / RR / UL1 RR024120
  • [Publication-type] Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] JL5DK93RCL / Melatonin
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57. Distler M, Kersting S, Rückert F, Dobrowolski F, Miehlke S, Grützmann R, Saeger HD: Palliative treatment of obstructive jaundice in patients with carcinoma of the pancreatic head or distal biliary tree. Endoscopic stent placement vs. hepaticojejunostomy. JOP; 2010;11(6):568-74
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  • We also determined the frequency of re-hospitalization for recurrent jaundice.
  • Considering that biliary stents can occlude, a hepaticojejunostomy may be superior to endoscopic stenting; hepaticojejunostomy should be especially favored in patients whose disease is first found to be unresectable intraoperatively.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biliary Tract / pathology. Endoscopy. Female. Humans. Liver / surgery. Male. Middle Aged. Palliative Care / methods. Retrospective Studies

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  • (PMID = 21068488.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
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58. Khouri IF, Saliba RM, Hosing C, Okoroji GJ, Acholonu S, Anderlini P, Couriel D, De Lima M, Donato ML, Fayad L, Giralt S, Jones R, Korbling M, Maadani F, Manning JT, Pro B, Shpall E, Younes A, McLaughlin P, Champlin RE: Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin's lymphomas. J Clin Oncol; 2005 Apr 1;23(10):2240-7
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  • [Title] Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin's lymphomas.
  • PURPOSE: We investigated the efficacy and safety of administering high-dose rituximab (HD-R) in combination with high-dose carmustine, cytarabine, etoposide, and melphalan chemotherapy and autologous stem-cell transplantation (SCT) in patients with recurrent B-cell aggressive non-Hodgkin's lymphoma (NHL).
  • HD-R of 1,000 mg/m(2) was administered again days 1 and 8 after transplantation.
  • Disease-free survival was 67% (95% CI, 51% to 79%) for the study group and 43% (95% CI, 26% to 60%) for the control group (P = .004).
  • CONCLUSION: The results of this study suggest that using HD-R and autologous SCT is a feasible and promising treatment for patients with B-cell aggressive NHL.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / drug therapy. Stem Cell Transplantation
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal, Murine-Derived. Carmustine / administration & dosage. Cytarabine / administration & dosage. Disease-Free Survival. Etoposide / administration & dosage. Female. Humans. Infusions, Intravenous. Injections, Subcutaneous. Male. Melphalan / administration & dosage. Middle Aged. Rituximab. Transplantation, Autologous. Treatment Outcome

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  • (PMID = 15800314.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 04079A1RDZ / Cytarabine; 4F4X42SYQ6 / Rituximab; 6PLQ3CP4P3 / Etoposide; Q41OR9510P / Melphalan; U68WG3173Y / Carmustine
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59. Shinawi M, Schaaf CP, Bhatt SS, Xia Z, Patel A, Cheung SW, Lanpher B, Nagl S, Herding HS, Nevinny-Stickel C, Immken LL, Patel GS, German JR, Beaudet AL, Stankiewicz P: A small recurrent deletion within 15q13.3 is associated with a range of neurodevelopmental phenotypes. Nat Genet; 2009 Dec;41(12):1269-71
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  • [Title] A small recurrent deletion within 15q13.3 is associated with a range of neurodevelopmental phenotypes.
  • We report a recurrent 680-kb deletion within chromosome 15q13.3 in ten individuals, from four unrelated families, with neurodevelopmental phenotypes including developmental delay, mental retardation and seizures.

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  • (PMID = 19898479.001).
  • [ISSN] 1546-1718
  • [Journal-full-title] Nature genetics
  • [ISO-abbreviation] Nat. Genet.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD-037283; United States / NICHD NIH HHS / HD / HD037283-10; United States / NICHD NIH HHS / HD / HD037283-09; United States / NICHD NIH HHS / HD / HD037283-12; United States / NCRR NIH HHS / RR / M01-RR00188; United States / NICHD NIH HHS / HD / R01 HD037283-10; United States / NCRR NIH HHS / RR / M01 RR000188; United States / NICHD NIH HHS / HD / R01 HD037283-08; United States / NICHD NIH HHS / HD / HD037283-08; United States / NICHD NIH HHS / HD / R01 HD037283; United States / NICHD NIH HHS / HD / P30 HD024064; United States / NCRR NIH HHS / RR / RR-019478; United States / NICHD NIH HHS / HD / R01 HD037283-12; United States / NCRR NIH HHS / RR / U54 RR019478; United States / NICHD NIH HHS / HD / HD-024064; United States / NICHD NIH HHS / HD / HD037283-11A2; United States / NICHD NIH HHS / HD / R01 HD037283-11A2; United States / NICHD NIH HHS / HD / R01 HD037283-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chrna7 protein, human; 0 / Receptors, Nicotinic; 0 / alpha7 Nicotinic Acetylcholine Receptor
  • [Other-IDs] NLM/ NIHMS292512; NLM/ PMC3158565
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60. Bulik CM, Von Holle A, Hamer R, Knoph Berg C, Torgersen L, Magnus P, Stoltenberg C, Siega-Riz AM, Sullivan P, Reichborn-Kjennerud T: Patterns of remission, continuation and incidence of broadly defined eating disorders during early pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). Psychol Med; 2007 Aug;37(8):1109-18
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  • EDNOS subtypes included binge eating disorder (BED) and recurrent self-induced purging in the absence of binge eating (EDNOS-P).

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  • [ErratumIn] Psychol Med. 2012 Apr;42(4):893
  • (PMID = 17493296.001).
  • [ISSN] 0033-2917
  • [Journal-full-title] Psychological medicine
  • [ISO-abbreviation] Psychol Med
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD047186-01A1; United States / NINDS NIH HHS / NS / 1 U01 NS 047537-01; United States / NICHD NIH HHS / HD / R01 HD047186; United States / NINDS NIH HHS / NS / U01 NS047537; United States / NIEHS NIH HHS / ES / N01 ES-85433; United States / NICHD NIH HHS / HD / HD047186-01A1; United States / NICHD NIH HHS / HD / HD047186
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS95308; NLM/ PMC2657803
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61. Bartsch R, Weitmann HD, Pennwieser W, Wenzel C, Muschitz S, Baldass M, Hassler M, Marosi C, Rössler K, Pötter R, Dieckmann K: Retrospective analysis of re-irradiation in malignant glioma: a single-center experience. Wien Klin Wochenschr; 2005 Dec;117(23-24):821-6
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  • We evaluated the safety and efficacy of re-irradiation in patients with recurrent malignant glioma.
  • PATIENTS AND METHODS: Twenty-two patients were treated with a second irradiation for recurrent or progressive glioma.
  • [MeSH-minor] Adolescent. Adult. Aged. Austria / epidemiology. Child. Feasibility Studies. Female. Humans. Incidence. Male. Middle Aged. Radiosurgery / statistics & numerical data. Radiotherapy, Adjuvant / statistics & numerical data. Radiotherapy, Conformal / statistics & numerical data. Retrospective Studies. Risk Assessment. Risk Factors. Survival Analysis. Survival Rate. Treatment Outcome

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  • (PMID = 16437319.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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62. Meira FS, Poli de Figueiredo CE, Figueiredo AE: Influence of sodium profile in preventing complications during hemodialysis. Hemodial Int; 2007 Oct;11 Suppl 3:S29-32
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  • Although a safe procedure, hemodialysis (HD) can cause numerous complications.
  • The objective of this study was to evaluate the incidence of complications during dialysis, interdialytic weight gain, and the predialysis and postdialysis blood pressure in HD patients with and without variable sodium.
  • Patients were observed during 12 HD sessions and those presenting with recurrent hypotension were selected for a step-wise model of variable sodium profiling.
  • [MeSH-minor] Adult. Aged. Dialysis Solutions / chemistry. Dialysis Solutions / pharmacology. Female. Humans. Hypotension / drug therapy. Hypotension / prevention & control. Male. Middle Aged. Muscle Cramp / etiology

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  • (PMID = 17897108.001).
  • [ISSN] 1492-7535
  • [Journal-full-title] Hemodialysis international. International Symposium on Home Hemodialysis
  • [ISO-abbreviation] Hemodial Int
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Dialysis Solutions; 9NEZ333N27 / Sodium
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63. Grobman WA, Lai Y, Landon MB, Spong CY, Leveno KJ, Rouse DJ, Varner MW, Moawad AH, Caritis SN, Harper M, Wapner RJ, Sorokin Y, Miodovnik M, Carpenter M, O'Sullivan MJ, Sibai BM, Langer O, Thorp JM, Ramin SM, Mercer BM, National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU): Development of a nomogram for prediction of vaginal birth after cesarean delivery. Obstet Gynecol; 2007 Apr;109(4):806-12
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  • The prediction model is based on a multivariable logistic regression, including the variables of maternal age, body mass index, ethnicity, prior vaginal delivery, the occurrence of a VBAC, and a potentially recurrent indication for the cesarean delivery.
  • [MeSH-minor] Adolescent. Adult. Body Mass Index. Continental Population Groups. Female. Forecasting. Humans. Maternal Age. Pregnancy. Pregnancy Complications. ROC Curve. Retrospective Studies

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  • [CommentIn] Obstet Gynecol. 2007 Apr;109(4):796-7 [17400837.001]
  • (PMID = 17400840.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD21410; United States / NICHD NIH HHS / HD / HD21414; United States / NICHD NIH HHS / HD / HD27860; United States / NICHD NIH HHS / HD / HD27861; United States / NICHD NIH HHS / HD / HD27869; United States / NICHD NIH HHS / HD / HD27905; United States / NICHD NIH HHS / HD / HD27915; United States / NICHD NIH HHS / HD / HD27917; United States / NICHD NIH HHS / HD / HD34116; United States / NICHD NIH HHS / HD / HD34122; United States / NICHD NIH HHS / HD / HD34136; United States / NICHD NIH HHS / HD / HD34208; United States / NICHD NIH HHS / HD / HD34210; United States / NICHD NIH HHS / HD / HD36801; United States / NICHD NIH HHS / HD / HD40485; United States / NICHD NIH HHS / HD / HD40500; United States / NICHD NIH HHS / HD / HD40512; United States / NICHD NIH HHS / HD / HD40544; United States / NICHD NIH HHS / HD / HD40545; United States / NICHD NIH HHS / HD / HD40560
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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64. de Kovel CG, Trucks H, Helbig I, Mefford HC, Baker C, Leu C, Kluck C, Muhle H, von Spiczak S, Ostertag P, Obermeier T, Kleefuss-Lie AA, Hallmann K, Steffens M, Gaus V, Klein KM, Hamer HM, Rosenow F, Brilstra EH, Trenité DK, Swinkels ME, Weber YG, Unterberger I, Zimprich F, Urak L, Feucht M, Fuchs K, Møller RS, Hjalgrim H, De Jonghe P, Suls A, Rückert IM, Wichmann HE, Franke A, Schreiber S, Nürnberg P, Elger CE, Lerche H, Stephani U, Koeleman BP, Lindhout D, Eichler EE, Sander T: Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies. Brain; 2010 Jan;133(Pt 1):23-32
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  • [Title] Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies.
  • Studies of structural genomic variations have revealed a significant excess of recurrent microdeletions at 1q21.1, 15q11.2, 15q13.3, 16p11.2, 16p13.11 and 22q11.2 in various neuropsychiatric disorders including autism, intellectual disability and schizophrenia.
  • Microdeletions at 15q13.3 have recently been shown to constitute a strong genetic risk factor for common idiopathic generalized epilepsy syndromes, implicating that other recurrent microdeletions may also be involved in epileptogenesis.
  • The present results indicate an involvement of microdeletions at 15q11.2 and 16p13.11 in epileptogenesis and strengthen the evidence that recurrent microdeletions at 15q11.2, 15q13.3 and 16p13.11 confer a pleiotropic susceptibility effect to a broad range of neuropsychiatric disorders.

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  • (PMID = 19843651.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD043376; United States / NICHD NIH HHS / HD / HD043569; United States / Howard Hughes Medical Institute / /
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2801323
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65. Singh NA, Otto JF, Dahle EJ, Pappas C, Leslie JD, Vilaythong A, Noebels JL, White HS, Wilcox KS, Leppert MF: Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol; 2008 Jul 15;586(14):3405-23
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  • Adult Kcnq2(A306T/+) and Kcnq3(G311V/+) heterozygous knock-in mice exhibited reduced thresholds to electrically induced seizures compared to wild-type littermate mice.
  • Mice had recurrent seizures into adulthood that triggered molecular plasticity including ectopic neuropeptide Y (NPY) expression in granule cells, but without hippocampal mossy fibre sprouting or neuronal loss.
  • These novel knocking mice recapitulate proconvulsant features of the human disorder yet show that inherited M-current defects spare granule cells from reactive changes in adult hippocampal networks.

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  • (PMID = 18483067.001).
  • [ISSN] 1469-7793
  • [Journal-full-title] The Journal of physiology
  • [ISO-abbreviation] J. Physiol. (Lond.)
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS032666; United States / NINDS NIH HHS / NS / R01 NS044210; United States / NICHD NIH HHS / HD / HD-24064; United States / NICHD NIH HHS / HD / P30 HD024064; United States / NINDS NIH HHS / NS / R01 NS-32666; United States / NINDS NIH HHS / NS / R01 NS-29709; United States / NINDS NIH HHS / NS / R01 NS-44210; United States / NINDS NIH HHS / NS / R56 NS032666
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / KCNQ2 Potassium Channel; 0 / KCNQ3 Potassium Channel; 0 / Kcnq2 protein, mouse; 0 / Kcnq3 protein, mouse; 0 / Nerve Tissue Proteins
  • [Other-IDs] NLM/ PMC2538806
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66. Winkelstein JA, Marino MC, Lederman HM, Jones SM, Sullivan K, Burks AW, Conley ME, Cunningham-Rundles C, Ochs HD: X-linked agammaglobulinemia: report on a United States registry of 201 patients. Medicine (Baltimore); 2006 Jul;85(4):193-202
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  • Seventy percent of patients had at least 1 episode of otitis, 62% at least 1 episode of pneumonia, 60% at least 1 episode of sinusitis, 23% at least 1 episode of chronic/recurrent diarrhea, 21% at least 1 episode of conjunctivitis, 18% at least 1 episode of pyoderma and/or cellulitis, 11% at least 1 episode of meningitis/encephalitis, 10% at least 1 episode of sepsis, 8% at least 1 episode of septic arthritis, 6% at least 1 episode of hepatitis, and 3% at least 1 episode of osteomyelitis.
  • Causes of death included disseminated enterovirus infection (n = 6), pulmonary insufficiency (n = 5), adenovirus infection (n = 1), sepsis (n = 1), acquired immunodeficiency disease syndrome (AIDS) (n = 1), myocarditis (n = 1), hepatitis (n = 2), and stem cell transplantation (n = 1).
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Cause of Death. Child. Child, Preschool. Humans. Incidence. Infant. Male. Middle Aged. Prevalence. Registries. United States / epidemiology


67. Johnson JN, Hofman N, Haglund CM, Cascino GD, Wilde AA, Ackerman MJ: Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy. Neurology; 2009 Jan 20;72(3):224-31
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  • Like noncardiac organ phenotypes observed in other LQTS-susceptibility genes such as KCNQ1/deafness and SCN5A/gastrointestinal symptoms, this novel LQT2-epilepsy association raises the possibility that LQT2-causing perturbations in the KCNH2-encoded potassium channel may confer susceptibility for recurrent seizure activity.

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  • (PMID = 19038855.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD42569
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / KCNQ1 Potassium Channel
  • [Other-IDs] NLM/ PMC2677528
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68. Saunders LL, Selassie AW, Hill EG, Nicholas JS, Horner MD, Corrigan JD, Lackland DT: A population-based study of repetitive traumatic brain injury among persons with traumatic brain injury. Brain Inj; 2009 Oct;23(11):866-72
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  • METHODS AND PROCEDURES: There were 4357 persons with TBI who were followed from the index hospital discharge through 31 December 2005 for RTBI events through the statewide hospital discharge (HD) and emergency department (ED) records.
  • Prentice, Williams, Peterson total time/conditional probability model (PWP-CP) for recurrent events survival analysis was used to assess RTBI as a function of index TBI severity.
  • [MeSH-minor] Adult. Epilepsy / epidemiology. Epilepsy / etiology. Female. Humans. Male. Middle Aged. Population Surveillance. Proportional Hazards Models. Recurrence. Retrospective Studies. Risk Factors. South Carolina / epidemiology. Trauma Severity Indices

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  • (PMID = 20100122.001).
  • [ISSN] 1362-301X
  • [Journal-full-title] Brain injury
  • [ISO-abbreviation] Brain Inj
  • [Language] eng
  • [Grant] United States / PHS HHS / / U17/CCU421926
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
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69. De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY: Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. BMC Cancer; 2006 Sep 12;6:223
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  • Recurrent amplifications at 2p23-p24, 2q14, 7q34, and 12p13 were also observed.

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  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA105607; United States / NICHD NIH HHS / HD / HD042977; United States / NINDS NIH HHS / NS / NS043517; United States / NICHD NIH HHS / HD / T32 HD042977; United States / NCI NIH HHS / CA / R01 CA105607; United States / NINDS NIH HHS / NS / K08 NS043517; United States / NICHD NIH HHS / HD / K12 HD041648; United States / NCI NIH HHS / CA / R01 CA109467; United States / NICHD NIH HHS / HD / HD041648; United States / NCI NIH HHS / CA / CA109467
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Peptide Elongation Factor 1; 0 / Ribosomal Proteins; 0 / ribosomal protein L30; 0 / ribosomal protein S20
  • [Other-IDs] NLM/ PMC1578584
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70. Okada H, Lieberman FS, Walter KA, Lunsford LD, Kondziolka DS, Bejjani GK, Hamilton RL, Torres-Trejo A, Kalinski P, Cai Q, Mabold JL, Edington HD, Butterfield LH, Whiteside TL, Potter DM, Schold SC Jr, Pollack IF: Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas. J Transl Med; 2007;5:67
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  • METHODS: In University of Pittsburgh Cancer Institute (UPCI) protocol 95-033, adult participants with recurrent glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA) received gross total resection (GTR) of the recurrent tumors, followed by two vaccinations with autologous fibroblasts retrovirally transfected with TFG-IL4-Neo-TK vector admixed with irradiated autologous glioma cells.
  • In UPCI 99-111, adult participants with newly diagnosed GBM or AA, following GTR and radiation therapy, received two intradermal vaccinations with the TFG-IL4-Neo-TK-transfected fibroblasts admixed with type-1 dendritic cells (DC) loaded with autologous tumor lysate.
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Feasibility Studies. Female. Humans. Male. Middle Aged

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  • (PMID = 18093335.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Grant] United States / NCATS NIH HHS / TR / UL1 TR000005
  • [Publication-type] Clinical Trial, Phase I; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cancer Vaccines; 207137-56-2 / Interleukin-4
  • [Other-IDs] NLM/ PMC2254376
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71. Cheng IK, Ching AK, Chan TC, Chan AW, Wong CK, Choy KW, Kwan M, Lai PB, Wong N: Reduced CRYL1 expression in hepatocellular carcinoma confers cell growth advantages and correlates with adverse patient prognosis. J Pathol; 2010 Feb;220(3):348-60
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  • Array-CGH analysis on early passage of HCC cultures and cell lines led us to identify six homozygous deleted (HD) regions.
  • A high concordance between array-CGH and expression of HD genes was demonstrated, where crystallin Lambda1 (CRYL1; located on chromosome 13q12.11) displayed the most frequent down-regulation.
  • Significant associations could also be drawn between repressed CRYL1 and advanced tumour staging, increased tumour size, and shorter disease-free survival of patients (p < 0.037).
  • Moreover, homozygous deletions on CRYL1 could be detected in 36% of HCC cases, where recurrent HDs were identified on exons 1, 5, and 8.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Cycle / physiology. Comparative Genomic Hybridization / methods. Down-Regulation. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction / methods. Prognosis. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Survival Analysis. Tumor Cells, Cultured

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  • [Copyright] Copyright 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 19927314.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CRYL1 protein, human; 0 / Crystallins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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72. Berardo A, DiMauro S, Hirano M: A diagnostic algorithm for metabolic myopathies. Curr Neurol Neurosci Rep; 2010 Mar;10(2):118-26
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  • The wide clinical spectrum of metabolic myopathies ranges from severe infantile-onset multisystemic diseases to adult-onset isolated myopathies with exertional cramps.
  • Diagnosing these diverse disorders often is challenging because clinical features such as recurrent myoglobinuria and exercise intolerance are common to all three types of metabolic myopathy.

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  • (PMID = 20425236.001).
  • [ISSN] 1534-6293
  • [Journal-full-title] Current neurology and neuroscience reports
  • [ISO-abbreviation] Curr Neurol Neurosci Rep
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD057543; None / None / / R01 HD057543-03; United States / NICHD NIH HHS / HD / R01 HD057543-03
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 9005-79-2 / Glycogen
  • [Number-of-references] 53
  • [Other-IDs] NLM/ NIHMS195802; NLM/ PMC2872126
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73. Cody JD, Sebold C, Malik A, Heard P, Carter E, Crandall A, Soileau B, Semrud-Clikeman M, Cody CM, Hardies LJ, Li J, Lancaster J, Fox PT, Stratton RF, Perry B, Hale DE: Recurrent interstitial deletions of proximal 18q: a new syndrome involving expressive speech delay. Am J Med Genet A; 2007 Jun 1;143A(11):1181-90
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  • [Title] Recurrent interstitial deletions of proximal 18q: a new syndrome involving expressive speech delay.
  • [MeSH-minor] Adult. Anthropometry. Behavior. Child. Child, Preschool. Cognition. Female. Humans. Infant. Male. Neuropsychological Tests. Syndrome

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  • [Copyright] Copyright (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17486614.001).
  • [ISSN] 1552-4825
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR-01346; United States / NICHD NIH HHS / HD / R01-HD-045907
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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74. Gombatto SP, Collins DR, Sahrmann SA, Engsberg JR, Van Dillen LR: Patterns of lumbar region movement during trunk lateral bending in 2 subgroups of people with low back pain. Phys Ther; 2007 Apr;87(4):441-54
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  • SUBJECTS: Participants were 44 people (28 men and 16 women; age [X+/-SD], 28.5+/-8.4 years) with chronic or recurrent LBP.
  • [MeSH-minor] Adult. Female. Humans. Male. Torsion Abnormality

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  • (PMID = 17374634.001).
  • [ISSN] 0031-9023
  • [Journal-full-title] Physical therapy
  • [ISO-abbreviation] Phys Ther
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / 1 K01HD01226-05; United States / NICHD NIH HHS / HD / 5 T32 HD07434-10
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Thomas JS, France CR, Sha D, Vander Wiele N, Moenter S, Swank K: The effect of chronic low back pain on trunk muscle activations in target reaching movements with various loads. Spine (Phila Pa 1976); 2007 Dec 15;32(26):E801-8
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  • SUMMARY OF BACKGROUND DATA: Changes in the precise timing of trunk muscle activation may cause an initial episode of back pain, or contribute to the development of recurrent or chronic symptoms.
  • [MeSH-minor] Adolescent. Adult. Chronic Disease. Cross-Sectional Studies. Electromyography / methods. Female. Humans. Male. Reaction Time / physiology. Recurrence. Weight-Bearing / physiology

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  • (PMID = 18091474.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / R01-HD045512
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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76. Scharfman HE, Malthankar-Phatak GH, Friedman D, Pearce P, McCloskey DP, Harden CL, Maclusky NJ: A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. Endocrinology; 2009 Sep;150(9):4437-42
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  • The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats.
  • Mortality, morbidity, estrous cyclicity, and the ultimate success of the procedure (i.e. induction of recurrent, spontaneous seizures) were monitored.

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  • (PMID = 19443573.001).
  • [ISSN] 1945-7170
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R56 NS037562; United States / NINDS NIH HHS / NS / R01 NS037562; United States / NICHD NIH HHS / HD / U10 HD047890; United States / NINDS NIH HHS / NS / NS 37562; United States / NICHD NIH HHS / HD / HD 047890
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 01MI4Q9DI3 / Pilocarpine; 4F86W47BR6 / Raloxifene Hydrochloride; I4744080IR / Pentobarbital
  • [Other-IDs] NLM/ PMC2736077
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77. Gumus K, Mirza GE, Cavanagh HD, Karakucuk S: Topical cyclosporine A as a steroid-sparing agent in steroid-dependent idiopathic ocular myositis with scleritis: a case report and review of the literature. Eye Contact Lens; 2009 Sep;35(5):275-8
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  • Laboratory examination results showed no evidence of dysthyroid ophthalmopathy or another systemic disease.
  • Using only topical cyclosporine A, she currently has no recurrences of disease on the last examination after 6 months of treatment.
  • It should be considered as a steroid-sparing agent, particularly in recurrent disease and in those patients who experience adverse effects of systemic medications.
  • [MeSH-minor] Administration, Topical. Adult. Anti-Inflammatory Agents / administration & dosage. Dexamethasone / administration & dosage. Drug Administration Schedule. Drug Therapy, Combination. Eye Movements. Female. Humans. Magnetic Resonance Imaging. Treatment Outcome

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  • (PMID = 19687744.001).
  • [ISSN] 1542-233X
  • [Journal-full-title] Eye & contact lens
  • [ISO-abbreviation] Eye Contact Lens
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Enzyme Inhibitors; 7S5I7G3JQL / Dexamethasone; 83HN0GTJ6D / Cyclosporine
  • [Number-of-references] 19
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78. Miodrag N, Hodapp RM: Chronic stress and health among parents of children with intellectual and developmental disabilities. Curr Opin Psychiatry; 2010 Sep;23(5):407-11
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  • So far, increased rates of caregiver health problems have been linked to caring for an elderly parent or for a child with recurrent cancer.
  • [MeSH-minor] Adult. Caregivers / psychology. Child. Health Status. Humans


79. Ishikawa H, Reierstad S, Demura M, Rademaker AW, Kasai T, Inoue M, Usui H, Shozu M, Bulun SE: High aromatase expression in uterine leiomyoma tissues of African-American women. J Clin Endocrinol Metab; 2009 May;94(5):1752-6
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  • CONTEXT: Symptomatic uterine leiomyoma is associated with irregular uterine bleeding, anemia, and recurrent pregnancy loss.

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  • (PMID = 19240151.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD046260; United States / NICHD NIH HHS / HD / HD46260
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Progestins; 0 / RNA, Messenger; 0 / Receptors, Progesterone; EC 1.14.14.1 / Aromatase
  • [Other-IDs] NLM/ PMC2684481
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80. Trcić RL, Sustercić D, Kuspilić M, Jelić-Puskarić B, Fabijanić I, Kardum-Skelin I: Recurrent chromosomal abnormalities in lymphomas in fine needle aspirates of lymph node. Coll Antropol; 2010 Jun;34(2):387-93
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  • [Title] Recurrent chromosomal abnormalities in lymphomas in fine needle aspirates of lymph node.
  • This has been accomplished by using the fluorescent in situ hybridisation method (FISH) performed on fine needle aspiration (FNA) specimens what is attractive in the diagnosis of lymphoma in the comparation with other methods for collecting samples.
  • The cytogenetic analyses were performed in series of 80 patients with lymphoma (43 women and 37 men, median age 48, range 3-90 years).
  • In our series 89.0% (71) of the specimens yield sufficient numbers of analysable metaphases, comprising 63 non-Hodgkin lymphomas (NHL) and 8 examples of Hodgkin disease (HD).
  • Four abnormal clones detected in Hodgkin disease were typically consisted of a small percentage of metaphases.
  • [MeSH-major] Chromosome Aberrations / classification. Lymph Nodes / pathology. Lymphoma / genetics. Lymphoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle / methods. Biopsy, Needle / methods. Female. Gene Rearrangement / genetics. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Lymphoma, B-Cell / genetics. Lymphoma, B-Cell / pathology. Lymphoma, T-Cell / genetics. Lymphoma, T-Cell / pathology. Male. Middle Aged. Translocation, Genetic

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  • (PMID = 20698107.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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81. White HD, Braunwald E, Murphy SA, Jacob AJ, Gotcheva N, Polonetsky L, Antman EM: Enoxaparin vs. unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction in elderly and younger patients: results from ExTRACT-TIMI 25. Eur Heart J; 2007 May;28(9):1066-71
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  • The relative risk reduction (RR) with ENOX on the primary endpoint, i.e. death or non-fatal recurrent myocardial infarction, was greater in patients < 75 years (20%) than > 75 years (6%), but the absolute benefits were similar.
  • [MeSH-minor] Adult. Age Factors. Death, Sudden, Cardiac / etiology. Double-Blind Method. Enoxaparin / therapeutic use. Female. Hemorrhage / etiology. Humans. Male. Middle Aged. Secondary Prevention. Treatment Outcome

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  • (PMID = 17456482.001).
  • [ISSN] 0195-668X
  • [Journal-full-title] European heart journal
  • [ISO-abbreviation] Eur. Heart J.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enoxaparin; 9005-49-6 / Heparin
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82. Clyne OJ, O'Sullivan O, Flood HD: Pubovaginal sling for urodynamic stress incontinence: effect on patient quality of life. Ir Med J; 2005 Mar;98(3):75-7
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  • At 6 months 95% of the subjects remained dry, 3 complained of recurrent USI, 7 complained of urgency and 1 of UI.
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Length of Stay. Middle Aged. Prospective Studies. Quality of Life. Treatment Outcome. Urodynamics

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  • (PMID = 15869063.001).
  • [ISSN] 0332-3102
  • [Journal-full-title] Irish medical journal
  • [ISO-abbreviation] Ir Med J
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Ireland
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83. Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD: Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood; 2005 Mar 1;105(5):1881-90
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  • The hyper immunoglobulin M (IgM) syndrome (HIGM), characterized by recurrent infections, low serum IgG and IgA, normal or elevated IgM, and defective class switch recombination and somatic hypermutation, is a heterogenous disorder with at least 5 distinct molecular defects, including mutations of the genes coding for the CD40 ligand (CD40L) and IKK-gamma (NEMO) genes, both X-linked; and mutations of CD40, activation-induced cytidine deaminase (AICDA), and uracil-DNA glycosylase (UNG), associated with autosomal recessive HIGM syndromes.
  • We found mutations of CD40L in 98 males; AICDA in 4 patients (3 males, 1 female); UNG in one adult male; and Btk in 3 boys.
  • [MeSH-minor] Adult. Antigens, CD40 / genetics. CD40 Ligand / genetics. Cohort Studies. Cytidine Deaminase. Cytosine Deaminase / genetics. DNA Glycosylases / genetics. Family Health. Female. Humans. I-kappa B Kinase. Male. Molecular Epidemiology. Mutation. Prevalence. Protein-Serine-Threonine Kinases / genetics. Protein-Tyrosine Kinases / genetics. Uracil-DNA Glycosidase

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  • (PMID = 15358621.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD 17427-33
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD40; 0 / Immunoglobulin M; 147205-72-9 / CD40 Ligand; EC 2.7.1.- / IKBKE protein, human; EC 2.7.10.1 / Agammaglobulinaemia tyrosine kinase; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.10 / CHUK protein, human; EC 2.7.11.10 / I-kappa B Kinase; EC 2.7.11.10 / IKBKB protein, human; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / Uracil-DNA Glycosidase; EC 3.5.4.- / AICDA (activation-induced cytidine deaminase); EC 3.5.4.1 / Cytosine Deaminase; EC 3.5.4.5 / Cytidine Deaminase
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84. Huang S, Kennedy BK, Oshima J: LMNA mutations in progeroid syndromes. Novartis Found Symp; 2005;264:197-202; discussion 202-7, 227-30
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  • The two best-known examples are Hutchinson-Gilford progeria syndrome (HGPS, 'Progeria of childhood') and Werner syndrome (WS, 'Progeria of the adult').
  • A novel, recurrent de novo mutation in the LMNA gene, responsible for the majority of HGPS cases, results in an in-frame deletion of 50 amino acids, including endoproteolytic sites required for processing of prelamin A to mature lamin A protein.

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  • (PMID = 15773755.001).
  • [ISSN] 1528-2511
  • [Journal-full-title] Novartis Foundation symposium
  • [ISO-abbreviation] Novartis Found. Symp.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD44782
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lamin Type A
  • [Number-of-references] 15
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85. Catov JM, Wu CS, Olsen J, Sutton-Tyrrell K, Li J, Nohr EA: Early or recurrent preterm birth and maternal cardiovascular disease risk. Ann Epidemiol; 2010 Aug;20(8):604-9
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  • [Title] Early or recurrent preterm birth and maternal cardiovascular disease risk.
  • PURPOSE: Preterm birth (PTB) has been associated with a later increased risk of maternal cardiovascular disease (CVD).
  • We hypothesized a more pronounced relation between early or recurrent PTB and maternal CVD risk.
  • Recurrent PTB was associated with higher CVD morbidity compared to women with one PTB, particularly for ischemic events (HR = 1.78 [1.40, 2.27] vs. 1.22 [1.09, 1.36]).
  • CONCLUSIONS: Women with PTB, especially recurrent PTB, were at increased risk for CVD, suggesting common causes of these conditions.

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20609340.001).
  • [ISSN] 1873-2585
  • [Journal-full-title] Annals of epidemiology
  • [ISO-abbreviation] Ann Epidemiol
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD043441-09; United States / NICHD NIH HHS / HD / K12 HD043441; United States / NICHD NIH HHS / HD / K12 HD043441-09; United States / NICHD NIH HHS / HD / K12HD043441-06
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS209658; NLM/ PMC2901249
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86. Li J, Yan DL, Zhang ZH: Percutaneous cervical nucleoplasty in the treatment of cervical disc herniation. Eur Spine J; 2008 Dec;17(12):1664-9
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  • The angular displacement (AD) > or =11 degrees or horizontal displacement (HD) > or =3 mm was considered to be radiographically unstable.
  • There were no recurrent cases or complications in our series.
  • [MeSH-minor] Adult. Aged. Catheterization / adverse effects. Catheterization / standards. Decompression, Surgical / adverse effects. Decompression, Surgical / instrumentation. Decompression, Surgical / methods. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / instrumentation. Minimally Invasive Surgical Procedures / methods. Neck Pain / etiology. Neck Pain / surgery. Outcome Assessment (Health Care) / methods. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Prospective Studies. Radiculopathy / pathology. Radiculopathy / radiography. Radiculopathy / surgery. Spondylosis / pathology. Spondylosis / radiography. Spondylosis / surgery. Treatment Outcome


87. Tartaglia M, Martinelli S, Stella L, Bocchinfuso G, Flex E, Cordeddu V, Zampino G, Burgt Iv, Palleschi A, Petrucci TC, Sorcini M, Schoch C, Foa R, Emanuel PD, Gelb BD: Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am J Hum Genet; 2006 Feb;78(2):279-90
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  • [Title] Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease.
  • To test this model, we investigated further the diversity of germline and somatic PTPN11 mutations, delineated the association of those mutations with disease, characterized biochemically a panel of mutant SHP-2 proteins recurring in NS, LS, and leukemia, and performed molecular dynamics simulations to determine the structural effects of selected mutations.
  • Our results document a strict correlation between the identity of the lesion and disease and demonstrate that NS-causative mutations have less potency for promoting SHP-2 gain of function than do leukemia-associated ones.
  • Furthermore, we show that the recurrent LS-causing Y279C and T468M amino acid substitutions engender loss of SHP-2 catalytic activity, identifying a previously unrecognized behavior for this class of missense PTPN11 mutations.
  • [MeSH-minor] Adult. Amino Acid Sequence. Cohort Studies. Female. Germ-Line Mutation. Humans. Male. Mutation. Protein Conformation. Protein Tyrosine Phosphatase, Non-Receptor Type 11

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  • (PMID = 16358218.001).
  • [ISSN] 0002-9297
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K24 HD001294; United States / NCI NIH HHS / CA / R01 CA095621; United States / NICHD NIH HHS / HD / HD01294; United States / NHLBI NIH HHS / HL / R01 HL071207; United States / NHLBI NIH HHS / HL / P50 HL074728; United States / NHLBI NIH HHS / HL / HL074728; United States / NCI NIH HHS / CA / CA095621; Italy / Telethon / / GGP04172; United States / NHLBI NIH HHS / HL / HL71207
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.1.3.48 / Protein Tyrosine Phosphatases
  • [Other-IDs] NLM/ PMC1380235
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88. Gunnarsdóttir A, Sandblom G, Arnbjörnsson E, Larsson LT: Quality of life in adults operated on for Hirschsprung disease in childhood. J Pediatr Gastroenterol Nutr; 2010 Aug;51(2):160-6
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  • [Title] Quality of life in adults operated on for Hirschsprung disease in childhood.
  • OBJECTIVES: The aim of this study is to explore the long-term quality of life (QoL) in adults after surgery for Hirschsprung disease in childhood.
  • PATIENTS AND METHODS: Altogether 51 patients were operated for HD at our center during the period 1969 to 1989.
  • At the last clinical control, 4 (9%) patients had a terminal enterostomy, 12 (29%) had soiling, 5 (12%) had constipation, and 2 (5%) experienced recurrent enterocolitis.
  • CONCLUSIONS: The long-term QoL of adults operated for Hirschsprung disease in their youth is satisfactory.
  • [MeSH-major] Hirschsprung Disease / surgery. Postoperative Complications. Quality of Life
  • [MeSH-minor] Adolescent. Adult. Constipation / epidemiology. Constipation / etiology. Enterocolitis / epidemiology. Enterocolitis / etiology. Enterostomy. Fecal Incontinence / epidemiology. Fecal Incontinence / etiology. Female. Follow-Up Studies. Humans. Linear Models. Male. Mental Health. Middle Aged. Multivariate Analysis. Sex Factors. Surveys and Questionnaires. Young Adult

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  • (PMID = 20453676.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Chenot JF, Becker A, Leonhardt C, Keller S, Donner-Banzhoff N, Hildebrandt J, Basler HD, Baum E, Kochen MM, Pfingsten M: Sex differences in presentation, course, and management of low back pain in primary care. Clin J Pain; 2008 Sep;24(7):578-84
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  • Logistic regression models-adjusting for sociodemographic and disease-related data-were conducted to investigate the effect of sex for the use of healthcare services.
  • They were more likely to have recurrent or chronic LBP and to have a positive depression score.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Germany / epidemiology. Humans. Male. Middle Aged. Prevalence. Primary Prevention / statistics & numerical data. Risk Factors. Sex Distribution. Treatment Outcome

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  • (PMID = 18716496.001).
  • [ISSN] 1536-5409
  • [Journal-full-title] The Clinical journal of pain
  • [ISO-abbreviation] Clin J Pain
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Muller J, Stoetzel C, Vincent MC, Leitch CC, Laurier V, Danse JM, Hellé S, Marion V, Bennouna-Greene V, Vicaire S, Megarbane A, Kaplan J, Drouin-Garraud V, Hamdani M, Sigaudy S, Francannet C, Roume J, Bitoun P, Goldenberg A, Philip N, Odent S, Green J, Cossée M, Davis EE, Katsanis N, Bonneau D, Verloes A, Poch O, Mandel JL, Dollfus H: Identification of 28 novel mutations in the Bardet-Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease. Hum Genet; 2010 Mar;127(5):583-93
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  • [Title] Identification of 28 novel mutations in the Bardet-Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease.
  • Bardet-Biedl syndrome (BBS), an emblematic disease in the rapidly evolving field of ciliopathies, is characterized by pleiotropic clinical features and extensive genetic heterogeneity.
  • Two pathogenic mutations in a single gene have been found in 117 families, and a single heterozygous mutation in 17 families (of which 8 involve the BBS1 recurrent mutation, M390R).
  • [MeSH-minor] Adult. Aged. Chromatography, High Pressure Liquid. Chromosome Mapping. Decision Trees. Female. Gene Deletion. Gene Duplication. Gene Frequency. Genetic Testing. Homozygote. Humans. Male. Microsatellite Repeats. Middle Aged. Molecular Sequence Data. Pedigree. Polymorphism, Single Nucleotide. Polymorphism, Single-Stranded Conformational. Sequence Analysis, DNA


91. West MJ, Nestel PJ, Kirby AC, Schnabel R, Sullivan D, Simes RJ, Pollicino C, Lubos E, Münzel TF, White HD, Tonkin AM, Bickel C, Tiret L, Blankenberg S, LIPID Study Investigators: The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study. Eur Heart J; 2008 Apr;29(7):923-31
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  • METHODS AND RESULTS: Plasma NT-proBNP and TIMP-1 were measured in a nested case control study of 250 randomly matched subject pairs enrolled in the long-term intervention with pravastatin in ischaemic disease (LIPID) and LIPID extended follow-up studies.
  • The odds ratio (OR) of recurrent cardiovascular events in individuals in the highest quartile was three times higher than those in the lowest quartile (95% confidence interval (CI) 1.8-5.1; P < 0.001).
  • CONCLUSION: The study suggests that in subjects with stable ischaemic disease, NT-proBNP and TIMP-1 are independent predictive markers of coronary heart disease outcome.
  • [MeSH-minor] Adult. Aged. Anticholesteremic Agents / therapeutic use. Biomarkers / blood. C-Reactive Protein / metabolism. Case-Control Studies. Coronary Angiography. Female. Humans. Leukocyte Count. Male. Middle Aged. Pravastatin / therapeutic use. Prognosis. Risk Factors

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  • [CommentIn] Eur Heart J. 2008 Apr;29(7):837-9 [18334472.001]
  • (PMID = 18296678.001).
  • [ISSN] 0195-668X
  • [Journal-full-title] European heart journal
  • [ISO-abbreviation] Eur. Heart J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticholesteremic Agents; 0 / Biomarkers; 0 / C-reactive protein (164-173); 0 / Peptide Fragments; 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / pro-brain natriuretic peptide (1-76); 114471-18-0 / Natriuretic Peptide, Brain; 9007-41-4 / C-Reactive Protein; KXO2KT9N0G / Pravastatin
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92. Saxena A, de Lagarde D, Leonard H, Williamson SL, Vasudevan V, Christodoulou J, Thompson E, MacLeod P, Ravine D: Lost in translation: translational interference from a recurrent mutation in exon 1 of MECP2. J Med Genet; 2006 Jun;43(6):470-7
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  • [Title] Lost in translation: translational interference from a recurrent mutation in exon 1 of MECP2.

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  • (PMID = 16155192.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD043100; United States / NICHD NIH HHS / HD / 1 R01 HD43100-01A1
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MECP2 protein, human; 0 / Methyl-CpG-Binding Protein 2; 0 / Protein Isoforms; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2593027
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93. Hannes FD, Sharp AJ, Mefford HC, de Ravel T, Ruivenkamp CA, Breuning MH, Fryns JP, Devriendt K, Van Buggenhout G, Vogels A, Stewart H, Hennekam RC, Cooper GM, Regan R, Knight SJ, Eichler EE, Vermeesch JR: Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant. J Med Genet; 2009 Apr;46(4):223-32
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  • [Title] Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant.

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  • (PMID = 18550696.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD043569; United States / NICHD NIH HHS / HD / HD043569; United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2658752
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94. Klebanoff MA, Meis PJ, Dombrowski MP, Zhao Y, Moawad AH, Northen A, Sibai BM, Iams JD, Varner MW, Caritis SN, O'Sullivan MJ, Leveno KJ, Miodovnik M, Conway D, Wapner RJ, Carpenter M, Mercer BM, Ramin SM, Thorp JM, Peaceman AM, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network: Salivary progesterone and estriol among pregnant women treated with 17-alpha-hydroxyprogesterone caproate or placebo. Am J Obstet Gynecol; 2008 Nov;199(5):506.e1-7
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  • Weekly salivary samples were obtained from 40 women who received 17OHPC and 40 who received placebo in a multicenter randomized trial of 17OHPC to prevent recurrent preterm delivery.

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  • (PMID = 18456237.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD36801; United States / PHS HHS / / NIH0010045861; United States / NICHD NIH HHS / HD / U10 HD040500; United States / NICHD NIH HHS / HD / HD27861; United States / NICHD NIH HHS / HD / UG1 HD027869; United States / NICHD NIH HHS / HD / HD27905; United States / NICHD NIH HHS / HD / U10 HD040544; United States / NICHD NIH HHS / HD / UG1 HD034116; United States / NICHD NIH HHS / HD / HD27869; United States / NICHD NIH HHS / HD / HD34136; United States / NICHD NIH HHS / HD / UG1 HD040560; United States / NICHD NIH HHS / HD / U10 HD034136; United States / NICHD NIH HHS / HD / HD27860; United States / NICHD NIH HHS / HD / UG1 HD027915; United States / NICHD NIH HHS / HD / U10 HD040485; United States / NICHD NIH HHS / HD / HD21414; United States / Intramural NIH HHS / / NIH0010045861; United States / NICHD NIH HHS / HD / U10 HD027905; United States / NICHD NIH HHS / HD / HD40512; United States / NICHD NIH HHS / HD / UG1 HD040544; United States / NICHD NIH HHS / HD / UG1 HD034208; United States / NICHD NIH HHS / HD / UG1 HD040512; United States / NICHD NIH HHS / HD / U10 HD034116; United States / NICHD NIH HHS / HD / HD40560; United States / NICHD NIH HHS / HD / HD34122; United States / NICHD NIH HHS / HD / HD34210; United States / NICHD NIH HHS / HD / HD21410; United States / NICHD NIH HHS / HD / U10 HD027869; United States / NICHD NIH HHS / HD / U10 HD027917; United States / NICHD NIH HHS / HD / HD34116; United States / NICHD NIH HHS / HD / U10 HD034122; United States / NICHD NIH HHS / HD / HD027860-09; United States / NICHD NIH HHS / HD / U10 HD027915; United States / NICHD NIH HHS / HD / U10 HD027860; United States / NICHD NIH HHS / HD / HD40500; United States / NICHD NIH HHS / HD / U10 HD040560; United States / NICHD NIH HHS / HD / U10 HD034208; United States / NICHD NIH HHS / HD / U10 HD027860-09; United States / NICHD NIH HHS / HD / HD34208; United States / NICHD NIH HHS / HD / HD27915; United States / NICHD NIH HHS / HD / UG1 HD040500; United States / NICHD NIH HHS / HD / U10 HD040512; United States / NICHD NIH HHS / HD / HD27917; United States / NICHD NIH HHS / HD / U10 HD021410; United States / NICHD NIH HHS / HD / U10 HD036801; United States / NICHD NIH HHS / HD / HD40544; United States / NICHD NIH HHS / HD / U01 HD036801
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydroxyprogesterones; 276F2O42F5 / 17-alpha-hydroxy-progesterone caproate; 4G7DS2Q64Y / Progesterone; FB33469R8E / Estriol
  • [Other-IDs] NLM/ NIHMS154735; NLM/ PMC2794481
  • [Investigator] Rouse D; Hauth J; Silver H; Tillinghast J; Catalano P; Milluzzi C; Jones P; Lindheimer M; Elder N; Siddiqi T; D'Alton M; Pemberton V; Das A; Zhao Y; Leindecker S; Cotroneo M; Lain K; Alfonso C; Beydoun S; Spong C; McNellis D; Pagliaro S; Dorman K; Moise K; Mallet G; Socol M; Johnson F; Landon M; Ramsey R; Langer O; Nicholson S; Day MC; Gilstrap L; Mc-Campbell J; Wendel G; Gabbe S; DiVito M; Tolosa J; Belfort M; Taggart E; Mueller-Heubach E; Swain M; Norman G; Sorokin Y
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95. Sipötz J, Gwechenberger M, Richter B, Adlbrecht C, Kornfeld G, Gössinger HD: Treatment of a recurrent atrial tachycardia by isolation of the right inferior pulmonary vein using a multi-electrode duty cycled ablation catheter. Europace; 2010 Dec;12(12):1788-9
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