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1. Darnall RA: The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonate. Respir Physiol Neurobiol; 2010 Oct 31;173(3):201-12
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  • The sites of central chemoreception active in the fetus are not known, but may involve the parafacial respiratory group which may be a precursor to the adult RTN.

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  • (PMID = 20399912.001).
  • [ISSN] 1878-1519
  • [Journal-full-title] Respiratory physiology & neurobiology
  • [ISO-abbreviation] Respir Physiol Neurobiol
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / P01 HD036379; United States / NICHD NIH HHS / HD / 5P01 HD036379-12
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
  • [Other-IDs] NLM/ NIHMS246302; NLM/ PMC2988425
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2. Simic-Ogrizovic S, Stosovic M, Novakovic I, Pejanovic S, Jemcov T, Radovic M, Djukanovic L: Fuzzy role of hyperhomocysteinemia in hemodialysis patients' mortality. Biomed Pharmacother; 2006 May;60(4):200-7
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  • Recent studies give contradictory data regarding the role of hyperhomocysteinemia (hyperHcy) in cardiovascular (CV) morbidity and mortality in hemodialysis (HD) patients.
  • The prospective follow-up study of 113 patients (52 males, aged 55.2+/-13.1 years) maintained by HD for 81.9+/-56.9 months at our Institute was carried out over 55 months.
  • The multivariate analysis showed HD duration (r=0.608; P=0.02) and folic acid serum level (r=-0.580; P=0.03) to be significant predictors of serum tHcy concentration.
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Homocysteine / blood. Humans. Male. Middle Aged

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  • (PMID = 16647238.001).
  • [ISSN] 0753-3322
  • [Journal-full-title] Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
  • [ISO-abbreviation] Biomed. Pharmacother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0LVT1QZ0BA / Homocysteine
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3. Hack M, Cartar L, Schluchter M, Klein N, Forrest CB: Self-perceived health, functioning and well-being of very low birth weight infants at age 20 years. J Pediatr; 2007 Dec;151(6):635-41, 641.e1-2
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  • However, we are concerned that their lesser resilience may prove detrimental to their future adult health.

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  • (PMID = 18035144.001).
  • [ISSN] 1097-6833
  • [Journal-full-title] The Journal of pediatrics
  • [ISO-abbreviation] J. Pediatr.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD034177-04; United States / NCRR NIH HHS / RR / M01RR00080; United States / NICHD NIH HHS / HD / HD034177-04; United States / NICHD NIH HHS / HD / R01 HD34177; United States / NICHD NIH HHS / HD / R01 HD034177; United States / NICHD NIH HHS / HD / HD034177-03; United States / NICHD NIH HHS / HD / R01 HD034177-03; United States / NCRR NIH HHS / RR / M01 RR000080
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS44355; NLM/ PMC2629999
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4. Bober SL, Park ER, Schmookler T, Medeiros Nancarrow C, Diller L: Perceptions of breast cancer risk and cancer screening: a qualitative study of young, female Hodgkin's disease survivors. J Cancer Educ; 2007;22(1):42-6
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  • [Title] Perceptions of breast cancer risk and cancer screening: a qualitative study of young, female Hodgkin's disease survivors.
  • BACKGROUND: Young female Hodgkins Disease (HD) survivors are at high risk for breast cancer following chest irradiation.
  • CONCLUSION: Female HD survivors would likely benefit from tailored education that links current beliefs with their previous cancer experience.
  • Education about cancer risk may be more effective if delivered in a health-promoting rather than disease-detection framework.
  • [MeSH-major] Breast Neoplasms / prevention & control. Hodgkin Disease / radiotherapy. Mass Screening. Neoplasms, Second Primary / prevention & control. Survivors
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Mammography. Prospective Studies. Risk Factors

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  • (PMID = 17570808.001).
  • [ISSN] 0885-8195
  • [Journal-full-title] Journal of cancer education : the official journal of the American Association for Cancer Education
  • [ISO-abbreviation] J Cancer Educ
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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5. Kollmann TR, Reikie B, Blimkie D, Way SS, Hajjar AM, Arispe K, Shaulov A, Wilson CB: Induction of protective immunity to Listeria monocytogenes in neonates. J Immunol; 2007 Mar 15;178(6):3695-701
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  • Listeria monocytogenes (Lm) targets the cytoplasm of APC and is a strong CD8 and CD4 Th1-promoting vaccine vehicle in adult mice.

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  • (PMID = 17339467.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / K08 HD051584-01; United States / NICHD NIH HHS / HD / HD051584-02; United States / NICHD NIH HHS / HD / K08 HD 049826; United States / NHLBI NIH HHS / HL / R01 HL069503; United States / NICHD NIH HHS / HD / R01 HD 018184; United States / NICHD NIH HHS / HD / K08 HD049826; United States / NICHD NIH HHS / HD / HD051584-01; United States / NHLBI NIH HHS / HL / R01 HL 069503; United States / NICHD NIH HHS / HD / K12 HD 043376; United States / NICHD NIH HHS / HD / K08 HD051584; United States / NICHD NIH HHS / HD / K12 HD043376; United States / NICHD NIH HHS / HD / K08 HD051584-02; United States / NICHD NIH HHS / HD / R01 HD018184
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Bacterial Proteins; 0 / Bacterial Vaccines; 0 / Membrane Proteins; 0 / Vaccines, Attenuated; 144430-05-7 / actA protein, Listeria monocytogenes
  • [Other-IDs] NLM/ NIHMS86197; NLM/ PMC2706399
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6. Budi EH, Patterson LB, Parichy DM: Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development; 2008 Aug;135(15):2603-14
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  • [Title] Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation.
  • Dramatic changes to the pigment pattern occur subsequently during the larva-to-adult transformation, or metamorphosis.
  • At this time, embryonic melanophores are replaced by newly differentiating metamorphic melanophores that form the adult stripes.
  • Mutants with normal embryonic/early larval pigment patterns but defective adult patterns identify factors required uniquely to establish, maintain or recruit the latent precursors to metamorphic melanophores.
  • These data identify a very early, embryonic, requirement for erbb3b in the development of much later metamorphic melanophores, and suggest complex modes by which ErbB signals promote adult pigment pattern development.

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  • (PMID = 18508863.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD007183; United States / NIGMS NIH HHS / GM / R01 GM 62182; United States / NIGMS NIH HHS / GM / R01 GM062182; United States / NIGMS NIH HHS / GM / R01 GM062182-08; None / None / / R01 GM062182-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / Receptor, ErbB-3
  • [Other-IDs] NLM/ NIHMS114036; NLM/ PMC2704560
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7. Rekik S, Trabelsi I, Hentati M, Hammami A, Jemaa MB, Hachicha J, Kammoun S: Infective endocarditis in hemodialysis patients: clinical features, echocardiographic data and outcome: a 10-year descriptive analysis. Clin Exp Nephrol; 2009 Aug;13(4):350-4
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  • BACKGROUND: Infective endocarditis (IE) is a dreaded complication in hemodialysis (HD) patients and is strongly associated with morbidity and mortality.
  • OBJECTIVES: Our aim was to investigate clinical and echocardiographic characteristics, microbiological profile, management and outcome of patients on HD in a Tunisian (Tunisia, North Africa) high-volume tertiary-care centre.
  • METHODS: Among 182 patients who fulfilled the modified Duke criteria for infective endocarditis between January 1997 and December 2006, 16 were on chronic HD and were included in the study.
  • [MeSH-minor] Adult. Aged. Candida albicans / isolation & purification. Cardiac Surgical Procedures. Developing Countries. Female. Hospital Mortality. Humans. Male. Methicillin Resistance. Middle Aged. Retrospective Studies. Staphylococcus / isolation & purification. Time Factors. Treatment Outcome. Tunisia / epidemiology


8. Hermann GM, Miller RL, Erkonen GE, Dallas LM, Hsu E, Zhu V, Roghair RD: Neonatal catch up growth increases diabetes susceptibility but improves behavioral and cardiovascular outcomes of low birth weight male mice. Pediatr Res; 2009 Jul;66(1):53-8
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  • Adult mice that experienced prenatal and neonatal growth restriction had persistent growth failure, hypertension, and neurobehavioral alterations.
  • Among low-birth weight female mice, neonatal catch up growth did not prevent the development of adult hypertension and significantly increased measures of anxiety, including self-injury and the avoidance of open spaces.
  • These studies support the importance of the perinatal environment in the resetting of adult disease susceptibility and suggest an earlier window of vulnerability among growth restricted female mice.

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  • (PMID = 19342983.001).
  • [ISSN] 1530-0447
  • [Journal-full-title] Pediatric research
  • [ISO-abbreviation] Pediatr. Res.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD050359-03; United States / NICHD NIH HHS / HD / K08 HD050359; United States / NICHD NIH HHS / HD / HD 050359; United States / NICHD NIH HHS / HD / K08 HD050359-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS117944; NLM/ PMC2703479
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9. Yashiro M, Watanabe H, Tomita M, Yamadori N, Muso E: Relationship between filtration coefficients of microvasculature and levels of atrial natriuretic peptide or echocardiographic measurements. Blood Purif; 2005;23(6):431-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND/AIMS: Assessing the volume status of hemodialysis (HD) patients and determining their adequate dry weight (DW) present great challenges for physicians involved in HD.
  • The aim of this study was to evaluate the possibility of utilizing Lpst as one of the tools for assessing volume status of patients undergoing HD.
  • METHODS: 52 patients on maintenance HD were examined.
  • Lpst was calculated by utilizing continuous measurements of blood volume during HD by means of monitoring changes of hematocrit with CRIT-LINE(TM).
  • Plasma ANP levels were measured shortly after HD.
  • These results suggested that Lpst can be utilized as one of the tools for assessing volume status of patients undergoing HD.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Echocardiography. Female. Humans. Male. Middle Aged

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16155375.001).
  • [ISSN] 0253-5068
  • [Journal-full-title] Blood purification
  • [ISO-abbreviation] Blood Purif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 85637-73-6 / Atrial Natriuretic Factor
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10. Hermann NV, Hove HD, Jørgensen C, Larsen P, Darvann TA, Kreiborg S, Sundberg K: Prenatal 3D ultrasound diagnostics in cleidocranial dysplasia. Fetal Diagn Ther; 2009;25(1):36-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Female. Humans. Pregnancy

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  • [Copyright] (c) 2009 S. Karger AG, Basel.
  • (PMID = 19169035.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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11. Richter WM, Axelson PW: Low-impact wheelchair propulsion: achievable and acceptable. J Rehabil Res Dev; 2005 May-Jun;42(3 Suppl 1):21-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Biomechanical Phenomena. Equipment Design. Female. Humans. Male. Patient Satisfaction

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  • (PMID = 16195960.001).
  • [ISSN] 0748-7711
  • [Journal-full-title] Journal of rehabilitation research and development
  • [ISO-abbreviation] J Rehabil Res Dev
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / 2 R44 HD36533-02A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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12. Willis BC, Borok Z: TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol; 2007 Sep;293(3):L525-34
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  • [Title] TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease.
  • We further describe the contribution of EMT to fibrosis in adult tissues following injury, focusing especially on the critical role of TGF-beta and its downstream mediators in this process.
  • Finally, we highlight recent descriptions of EMT in the lung and the potential implications of this process for the treatment of fibrotic lung disease.

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  • (PMID = 17631612.001).
  • [ISSN] 1040-0605
  • [Journal-full-title] American journal of physiology. Lung cellular and molecular physiology
  • [ISO-abbreviation] Am. J. Physiol. Lung Cell Mol. Physiol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12-HD-47349; United States / NHLBI NIH HHS / HL / R01-HL-38578; United States / NHLBI NIH HHS / HL / R01-HL-62569
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta
  • [Number-of-references] 123
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13. Candan C, Sever L, Civilibal M, Caliskan S, Arisoy N: Blood volume monitoring to adjust dry weight in hypertensive pediatric hemodialysis patients. Pediatr Nephrol; 2009 Mar;24(3):581-7
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  • The aim of this study was to adjust dry weight by short-term blood volume monitoring (BVM)-guided ultrafiltration and evaluate the effects of optimizing dry weight on blood pressure (BP) control and intradialytic symptoms (IDS) in a group of hypertensive hemodialysis (HD) patients.
  • The study was performed in four sequential phases, each of which lasted for 1 week, on nine hypertensive HD patients (six girls, age 16.9 +/- 3.1 years).
  • Pre- and post-HD body weight, pre-HD, post-HD, 30 min after HD casual BP values, and IDS in each HD session were recorded.
  • The results of this study suggest that short-term BVM guided-ultrafiltration may be a useful tool to diagnose volume overload and to adjust dry weight and, consequently, to achieve a better control of BP in pediatric HD patients.
  • [MeSH-minor] Adolescent. Adult. Blood Pressure Monitoring, Ambulatory. Child. Female. Humans. Male

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  • (PMID = 18781335.001).
  • [ISSN] 0931-041X
  • [Journal-full-title] Pediatric nephrology (Berlin, Germany)
  • [ISO-abbreviation] Pediatr. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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14. Prather H, Hunt D, Steger-May K, Hayes MH, Knaus E, Clohisy J: Inter-rater reliability of three musculoskeletal physical examination techniques used to assess motion in three planes while standing. PM R; 2009 Jul;1(7):629-35
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  • Twenty-eight adult volunteers were measured on both the left and right side by 2 independent raters on a single occasion.
  • [MeSH-minor] Adolescent. Adult. Biomechanical Phenomena. Female. Humans. Male. Middle Aged. Prospective Studies. Reproducibility of Results. Surveys and Questionnaires

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  • (PMID = 19627956.001).
  • [ISSN] 1934-1482
  • [Journal-full-title] PM & R : the journal of injury, function, and rehabilitation
  • [ISO-abbreviation] PM R
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12 HD055931; United States / NCRR NIH HHS / RR / UL1 RR024992; United States / NCATS NIH HHS / TR / UL1 TR000448; United States / NCRR NIH HHS / RR / UL 1RR024992
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS398569; NLM/ PMC3433850
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15. Cano AE, Neil AK, Kang JY, Barnabas A, Eastwood JB, Nelson SR, Hartley I, Maxwell D: Gastrointestinal symptoms in patients with end-stage renal disease undergoing treatment by hemodialysis or peritoneal dialysis. Am J Gastroenterol; 2007 Sep;102(9):1990-7
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  • [Title] Gastrointestinal symptoms in patients with end-stage renal disease undergoing treatment by hemodialysis or peritoneal dialysis.
  • OBJECTIVES: The aim of this study was to determine the prevalence of gastrointestinal symptoms in patients with end-stage renal disease undergoing hemodialysis (HD) or peritoneal dialysis (PD) treatment.
  • METHODS: Patients undergoing HD or chronic ambulatory PD in the Department of Renal Medicine of our hospital were asked to complete a locally validated Rome II questionnaire.
  • Patients on HD and their outpatient controls also completed the Hospital Anxiety and Depression Scale.
  • RESULTS: A total of 148 patients with end-stage renal disease (HD 100, PD 48) completed the study.
  • Among HD patients and their outpatient controls, the differences appeared to be unrelated to anxiety or depression.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anxiety / complications. Depression / complications. Female. Humans. Male. Middle Aged. Surveys and Questionnaires

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  • [CommentIn] Am J Gastroenterol. 2008 May;103(5):1317-8 [18477364.001]
  • (PMID = 17511755.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Lew-Williams C, Fernald A: Young children learning Spanish make rapid use of grammatical gender in spoken word recognition. Psychol Sci; 2007 Mar;18(3):193-8
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  • Adult native speakers of languages with grammatical gender exploit this cue in on-line sentence interpretation.
  • Spanish-learning children who can speak only 500 words already use gender-marked articles in establishing reference, a processing advantage characteristic of native Spanish-speaking adults.

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  • (PMID = 17444909.001).
  • [ISSN] 0956-7976
  • [Journal-full-title] Psychological science
  • [ISO-abbreviation] Psychol Sci
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC008838; United States / NICHD NIH HHS / HD / R01 HD042235; United States / NICHD NIH HHS / HD / R01 HD 42235
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS333796; NLM/ PMC3206966
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17. Zhou YL, Liu J, Sun F, Ma LJ, Han B, Shen Y, Cui TG: Calf bioimpedance ratio improves dry weight assessment and blood pressure control in hemodialysis patients. Am J Nephrol; 2010;32(2):109-16
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  • BACKGROUND: Chronic fluid overload due to overestimation of dry weight (DW) is the major factor in the development of hypertension in hemodialysis (HD) patients.
  • The present study was undertaken to investigate whether bioimpedance ratio in the calf (Calf-BR = impedance at 200 kHz/impedance at 5 kHz) could be a useful hydration marker for estimation of DW and facilitate better control of blood pressure (BP) in HD patients.
  • Post-dialysis Calf-BR was measured in 117 stable, non-edematous HD patients.
  • HD patients with Calf-BR above age-stratified target range had significantly higher home BP, in spite of more antihypertensive treatments (p = 0.058).
  • CONCLUSION: Recognition and correction of chronic fluid overload based on age-stratified Calf-BR is helpful in hypertension control in Chinese HD patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Asian Continental Ancestry Group. Body Composition / physiology. Body Water / physiology. Extracellular Fluid / physiology. Female. Humans. Hypertension / prevention & control. Kidney Failure, Chronic / therapy. Leg / physiology. Male. Middle Aged. Young Adult

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  • [Copyright] 2010 S. Karger AG, Basel.
  • (PMID = 20558982.001).
  • [ISSN] 1421-9670
  • [Journal-full-title] American journal of nephrology
  • [ISO-abbreviation] Am. J. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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18. Nacewicz BM, Dalton KM, Johnstone T, Long MT, McAuliff EM, Oakes TR, Alexander AL, Davidson RJ: Amygdala volume and nonverbal social impairment in adolescent and adult males with autism. Arch Gen Psychiatry; 2006 Dec;63(12):1417-28
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  • [Title] Amygdala volume and nonverbal social impairment in adolescent and adult males with autism.

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  • (PMID = 17146016.001).
  • [ISSN] 0003-990X
  • [Journal-full-title] Archives of general psychiatry
  • [ISO-abbreviation] Arch. Gen. Psychiatry
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / P30 HD003352; United States / NIMH NIH HHS / MH / U54 MH 066398; United States / NIMH NIH HHS / MH / U54 MH066398; United States / NICHD NIH HHS / HD / T32 HD007489; United States / NICHD NIH HHS / HD / T32 HD 07489; United States / NICHD NIH HHS / HD / P30 HD 03352
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS759714; NLM/ PMC4767012
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19. Hellebust TP, Kristensen GB, Olsen DR: Late effects after radiotherapy for locally advanced cervical cancer: comparison of two brachytherapy schedules and effect of dose delivered weekly. Int J Radiat Oncol Biol Phys; 2010 Mar 1;76(3):713-8
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  • METHODS AND MATERIALS: For 120 patients, intracavitary brachytherapy was delivered with 33.6 Gy in eight fractions to Point A (HD group), and for 119, intracavitary brachytherapy was delivered with 29.4 Gy in seven fractions to Point A (LD group).
  • RESULTS: The actuarial rate of developing severe gastrointestinal morbidity at 7 years was 10.7% and 8.3% for HD and LD groups, respectively.
  • The rate for genitourinary morbidity was 6.6% for the HD group and 5.0% for the LD group, respectively.
  • The analyses showed that a marginally significant increase occurred in severe gastrointestinal complications as the number of weeks with a physical dose >20 Gy increased in the HD group (p = .047).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Dose Fractionation. Female. Humans. Middle Aged. Radiation Tolerance. Time Factors


20. Saharan RS, Nantwi KD: Changes in the biochemical profiles of mid-cervically located adenosine A1 receptors after repeated theophylline administration in adult rats. J Spinal Cord Med; 2006;29(5):520-6
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  • [Title] Changes in the biochemical profiles of mid-cervically located adenosine A1 receptors after repeated theophylline administration in adult rats.
  • METHODS: Biochemical binding characteristics of adenosine A1 receptors in the C3 to C5 (PMN) of adult rats were assessed in naïve (n = 6) and theophylline-treated animals (n = 6) using [3H]-DPCPX (10 pmol/L to 30 nmol/L), the specific adenosine A1 receptor antagonist in saturation-binding assays.

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  • (PMID = 17274491.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD035766; United States / NICHD NIH HHS / HD / HD 35766
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bronchodilator Agents; 0 / Receptor, Adenosine A1; C137DTR5RG / Theophylline
  • [Other-IDs] NLM/ PMC1949029
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21. Gunaratne HJ, Moy GW, Kinukawa M, Miyata S, Mah SA, Vacquier VD: The 10 sea urchin receptor for egg jelly proteins (SpREJ) are members of the polycystic kidney disease-1 (PKD1) family. BMC Genomics; 2007 Jul 13;8:235
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  • [Title] The 10 sea urchin receptor for egg jelly proteins (SpREJ) are members of the polycystic kidney disease-1 (PKD1) family.
  • BACKGROUND: Mutations in the human polycystic kidney disease-1 (hPKD1) gene result in ~85% of cases of autosomal dominant polycystic kidney disease, the most frequent human monogenic disease.
  • All 10 SpREJs are transcribed in either embryos or adult tissues.
  • Adult tissues show tissue-specific patterns of SpREJ expression.

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  • (PMID = 17629917.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R37 HD012986; United States / NICHD NIH HHS / HD / HD12986
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Egg Proteins; 0 / TRPP Cation Channels; 0 / polycystic kidney disease 1 protein
  • [Other-IDs] NLM/ PMC1934368
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22. Han IC, Jaffe GJ: Evaluation of artifacts associated with macular spectral-domain optical coherence tomography. Ophthalmology; 2010 Jun;117(6):1177-1189.e4
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  • PARTICIPANTS: For the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA), scans of 98 eyes from 58 patients were included in the study.
  • MAIN OUTCOME MEASURES: Overall frequency of image artifacts by artifact type, relative frequency of artifacts in scans stratified by posterior segment disease diagnosis, and retinal thickness measurements of the center 1-mm subfield before and after artifact corrections.
  • Certain artifact types were observed more frequently with specific disease states.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • [Copyright] Copyright 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ophthalmology. 2011 Jan;118(1):222-222.e1 [21199718.001]
  • [CommentIn] Ophthalmology. 2011 Feb;118(2):429.e1 [21292120.001]
  • (PMID = 20171740.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30EY05722; United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Praetorius M, Hsu C, Baker K, Brough DE, Plinkert P, Staecker H: Adenovector-mediated hair cell regeneration is affected by promoter type. Acta Otolaryngol; 2010 Feb;130(2):215-22
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  • MATERIALS AND METHODS: Adenovector and promoter modifications were tested for differences in transgene expression in adult macular organs.
  • The effect of using viral and cellular promoters to modify transgene expression was tested in explanted adult mouse macular organs.
  • [MeSH-minor] Acoustic Maculae / physiology. Adenovirus E1A Proteins / genetics. Adenovirus E1A Proteins / metabolism. Animals. Disease Models, Animal. Ear, Inner / physiology. Gene Expression Regulation, Viral / genetics. Gene Transfer Techniques. Genetic Therapy. Glial Fibrillary Acidic Protein / metabolism. Green Fluorescent Proteins / metabolism. Mice. Mice, Inbred C57BL. Mice, Inbred CBA. Promoter Regions, Genetic / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transduction, Genetic. Transgenes / genetics. Ubiquitins / genetics. Ubiquitins / metabolism

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  • (PMID = 20095092.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P30 HD002528; United States / NIDCD NIH HHS / DC / R01 DC008424; United States / NICHD NIH HHS / HD / HD02528; United States / NIDCD NIH HHS / DC / R01DC008424
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenovirus E1A Proteins; 0 / Glial Fibrillary Acidic Protein; 0 / Ubiquitins; 147336-22-9 / Green Fluorescent Proteins
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24. Sanabria M, Muñoz J, Trillos C, Hernández G, Latorre C, Díaz CS, Murad S, Rodríguez K, Rivera A, Amador A, Ardila F, Caicedo A, Camargo D, Díaz A, González J, Leguizamón H, Lopera P, Marín L, Nieto I, Vargas E: Dialysis outcomes in Colombia (DOC) study: a comparison of patient survival on peritoneal dialysis vs hemodialysis in Colombia. Kidney Int Suppl; 2008 Apr;(108):S165-72
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  • The goal of the Dialysis Outcomes in Colombia (DOC) study was to compare the survival of patients on hemodialysis (HD) vs peritoneal dialysis (PD) in a network of renal units in Colombia.
  • There were 1094 eligible patients in total and 923 were actually enrolled: 47.3% started HD therapy and 52.7% started PD therapy.
  • Also, there were differences in the median survival time between groups: 27.2 months for PD vs 23.1 months for HD (P=0.001) by the intention-to-treat approach; and 24.5 months for PD vs 16.7 months for HD (P<0.001) by the as-treated approach.
  • When performing univariate Cox analyses using the intention-to-treat approach, associations were with age > or =65 years (hazard ratio (HR)=2.21; confidence interval (CI) 95% (1.77-2.755); P<0.001); history of cardiovascular disease (HR=1.96; CI 95% (1.58-2.90); P<0.001); diabetes (HR=2.34; CI 95% (1.88-2.90); P<0.001); and SGA (mild or moderate-severe malnutrition) (HR=1.47; CI 95% (1.17-1.79); P=0.001); but no association was found with gender (HR=1.03, CI 95% 0.83-1.27; P=0.786).
  • Similarly, the multivariate Cox model was run with the variables that had shown association in previous analyses, and it was found that the variables explaining the survival of patients with end-stage renal disease in our study were age, SGA, Charlson Comorbidity Index 5 and above, diabetes, healthcare regimes I and II, and socioeconomic level 2.
  • The results of Cox proportional risk model in both the as-treated and intention-to-treat analyses showed that there were no statistically significant differences in survival of PD and HD patients: intention-to-treat HD/PD (HR 1.127; CI 95%: 0.855-1.484) and as-treated HD/PD (HR 1.231; CI 95%: 0.976-1.553).
  • In this historical cohort of incident patients, there was a trend, although not statistically significant, for a higher (12.7%) adjusted mortality risk associated with HD when compared to PD, even though the PD patients were poorer, were more likely to be diabetic, and had higher co-morbidity scores than the HD patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Colombia. Diabetes Complications / complications. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Phosphorus / blood. Proportional Hazards Models. Socioeconomic Factors. Treatment Outcome

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  • (PMID = 18379541.001).
  • [ISSN] 0098-6577
  • [Journal-full-title] Kidney international. Supplement
  • [ISO-abbreviation] Kidney Int. Suppl.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 27YLU75U4W / Phosphorus
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25. Eason RR, Till SR, Velarde MC, Geng Y, Chatman L Jr, Gu L, Badger TM, Simmen FA, Simmen RC: Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. J Nutr Biochem; 2005 Oct;16(10):625-32
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  • [Title] Uterine phenotype of young adult rats exposed to dietary soy or genistein during development.
  • Here, we evaluated intermediate markers of cancer risk in uteri of cycling, young adult Sprague-Dawley rats lifetime exposed to one of three AIN-93G semipurified diets: casein (CAS), soy protein isolate (SPI+ with 276 mg GEN aglycone equivalents/kg) and CAS+GEN (GEN at 250 mg/kg).
  • Results suggest that lifetime dietary exposure to soy foods does not alter uterine cell phenotype in young adult rats, while GEN, by enhancing uterine endometrial glandular apoptosis in vivo and in vitro, may confer protection against uterine carcinoma.
  • Given its limited influence on uterine phenotype of young adult females, GEN, when taken as part of soy foods or as supplement, should be favorably considered for other potential health benefits.

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  • Hazardous Substances Data Bank. GENISTEIN .
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  • (PMID = 16081271.001).
  • [ISSN] 0955-2863
  • [Journal-full-title] The Journal of nutritional biochemistry
  • [ISO-abbreviation] J. Nutr. Biochem.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD21961
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caseins; 0 / Estrogens; 0 / Proliferating Cell Nuclear Antigen; 0 / Soybean Proteins; 4G7DS2Q64Y / Progesterone; 4TI98Z838E / Estradiol; DH2M523P0H / Genistein
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26. Henderson JA, Bethea CL: Differential effects of ovarian steroids and raloxifene on serotonin 1A and 2C receptor protein expression in macaques. Endocrine; 2008 Jun;33(3):285-93
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  • Adult rhesus macaques (Macaca mulatta) were ovariectomized (Ovx) and implanted with Silastic capsules containing E or P.

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  • (PMID = 19021000.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD07133; United States / NCRR NIH HHS / RR / P51 RR000163; United States / NIMH NIH HHS / MH / R01 MH062677; United States / NCRR NIH HHS / RR / RR00163; United States / NICHD NIH HHS / HD / U54 HD 18185; United States / NIMH NIH HHS / MH / MH62677; United States / NCRR NIH HHS / RR / K01 RR000163; United States / NICHD NIH HHS / HD / T32 HD007133; United States / NIMH NIH HHS / MH / R01 MH062677-03; United States / NICHD NIH HHS / HD / U54 HD018185
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Implants; 0 / Estrogen Antagonists; 0 / Receptor, Serotonin, 5-HT2C; 112692-38-3 / Receptor, Serotonin, 5-HT1A; 4F86W47BR6 / Raloxifene Hydrochloride; 4G7DS2Q64Y / Progesterone; 4TI98Z838E / Estradiol
  • [Other-IDs] NLM/ NIHMS347033; NLM/ PMC3267476
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27. Squitieri F, Frati L, Ciarmiello A, Lastoria S, Quarrell O: Juvenile Huntington's disease: does a dosage-effect pathogenic mechanism differ from the classical adult disease? Mech Ageing Dev; 2006 Feb;127(2):208-12
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  • [Title] Juvenile Huntington's disease: does a dosage-effect pathogenic mechanism differ from the classical adult disease?
  • Huntington's disease (HD) is caused by a CAG repeat mutation translating as a polyglutamine (poly(Q)) expansion in the huntingtin protein, whose main pathogenic mechanism is a gain of toxic function.
  • In the case of large expansions beyond 60 repeats onset may result in juvenile HD (JHD, onset before 20 years of age).
  • In this review we discuss the possibility that some of the pathogenic mechanisms contributing to age at onset and progression may differ in the early onset HD compared with the classical adult pathology.
  • [MeSH-major] Huntington Disease / genetics. Mutation. Nerve Tissue Proteins / genetics. Nuclear Proteins / genetics. Peptides / genetics. Trinucleotide Repeat Expansion / genetics. Trinucleotide Repeats / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Phenotype

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  • (PMID = 16274727.001).
  • [ISSN] 0047-6374
  • [Journal-full-title] Mechanisms of ageing and development
  • [ISO-abbreviation] Mech. Ageing Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / HTT protein, human; 0 / Nerve Tissue Proteins; 0 / Nuclear Proteins; 0 / Peptides; 26700-71-0 / polyglutamine
  • [Number-of-references] 40
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28. Alebous HD, Cartee R, Vaccari D, Wright OA, Ahmed A, Hood RD, Johnson MD: Developmental control of inositol phosphate biosynthesis is altered in the brain of both curly and phenotypically normal straight tail mutant mice. Birth Defects Res A Clin Mol Teratol; 2009 Oct;85(10):822-7
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  • METHODS: Utilizing enzyme assays to determine the specific activity of MIP, Western blotting to detect expression, gas chromatography/mass spectrometry to measure inositol concentration, and statistical analyses to evaluate quantitative data, MIP expression was analyzed in newborn, young, and adult brains of CBA and CT (curly tail [ct-CT] and straight tail [st-CT]) mutant mice.
  • Moreover, two differentially expressed forms of MIP were identified in the adult mouse brain.

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  • (PMID = 19645052.001).
  • [ISSN] 1542-0760
  • [Journal-full-title] Birth defects research. Part A, Clinical and molecular teratology
  • [ISO-abbreviation] Birth Defects Res. Part A Clin. Mol. Teratol.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inositol Phosphates; 4L6452S749 / Inositol; EC 5.5.1.4 / Myo-Inositol-1-Phosphate Synthase
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29. Hoffman AN, Malena RR, Westergom BP, Luthra P, Cheng JP, Aslam HA, Zafonte RD, Kline AE: Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience. Neurosci Lett; 2008 Feb 6;431(3):226-30
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  • To address this issue, isoflurane-anesthetized adult male rats received either a cortical impact or sham injury and were then randomly assigned to early EE, delayed EE, continuous EE or no EE (i.e., STD conditions).

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  • (PMID = 18162321.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS060005; United States / NICHD NIH HHS / HD / R01 HD046700-04; United States / NICHD NIH HHS / HD / HD043851-01; United States / NICHD NIH HHS / HD / R01 HD046700-02; United States / NICHD NIH HHS / HD / R03 HD043851-02; United States / NICHD NIH HHS / HD / R03 HD043851; United States / NICHD NIH HHS / HD / HD043851; United States / NICHD NIH HHS / HD / HD046700-01A1; United States / NICHD NIH HHS / HD / R01 HD046700-03; United States / NICHD NIH HHS / HD / R01 HD069620; United States / NICHD NIH HHS / HD / R03 HD043851-01; United States / NICHD NIH HHS / HD / R01 HD046700-01A1; United States / NICHD NIH HHS / HD / HD046700-02; United States / NICHD NIH HHS / HD / HD046700-03; United States / NICHD NIH HHS / HD / HD046700; United States / NICHD NIH HHS / HD / R01 HD046700
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Other-IDs] NLM/ NIHMS277374; NLM/ PMC3055238
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30. Reis A, Ihle P, Paulus U, Ferber LV, Diehl V, Walshe R: Cost of illness of malignant lymphoma in Germany. Eur J Cancer Care (Engl); 2006 Sep;15(4):379-85
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  • [Title] Cost of illness of malignant lymphoma in Germany.
  • The purpose of this study is to determine and compare the direct, indirect and societal costs of illness for Hodgkin's Disease (HD), Non-Hodgkin's Lymphoma (NHL), Plasmocytoma and Chronic Lymphatic Lymphoma (CLL).
  • We used a database of 1.9 million individuals enrolled in a statutory sickness fund in Germany to identify 4,172 patients treated for malignant lymphoma in 2000.
  • Direct cost (in Euro) for patients with HD was 3604, for NHL patients 6,149, for Plasmocytoma 8,400, and for CLL patients 3,226.
  • Total indirect cost for HD was 69 million, for NHL patients 404 million, for Plasmocytoma 144 million, and for CLL patients 52 million.
  • Totalling 1.7 billion Euro in economic cost for Germany in 2000, with 44,000 productive years lost, malignant lymphomas are a relatively costly disease group.
  • As life expectancy increases, costs for malignant lymphoma are likely to rise due to the high prevalence among the elderly.
  • [MeSH-major] Cost of Illness. Lymphoma / economics
  • [MeSH-minor] Adolescent. Adult. Aged. Case-Control Studies. Child. Child, Preschool. Costs and Cost Analysis. Direct Service Costs. Female. Germany. Humans. Infant. Infant, Newborn. Male. Middle Aged. Socioeconomic Factors

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  • (PMID = 16968321.001).
  • [ISSN] 0961-5423
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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31. Savin DN, Morton SM: Asymmetric generalization between the arm and leg following prism-induced visuomotor adaptation. Exp Brain Res; 2008 Mar;186(1):175-82
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  • In the current study, we tested healthy adult subjects performing one of three forms of prism adaptation and subsequently measured generalization.
  • [MeSH-minor] Adult. Female. Functional Laterality. Humans. Male

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  • (PMID = 18057927.001).
  • [ISSN] 1432-1106
  • [Journal-full-title] Experimental brain research
  • [ISO-abbreviation] Exp Brain Res
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD041899; United States / NICHD NIH HHS / HD / K01 HD050369-02; United States / NICHD NIH HHS / HD / HD050369; United States / NICHD NIH HHS / HD / HD041899; United States / NICHD NIH HHS / HD / K01 HD050369
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
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32. Codognotto M, Piccoli A, Zaninotto M, Mion MM, Ruzza L, Barchita A, Naso A, Plebani M: Effect of a dialysis session on the prognostic values of NT-proBNP, troponins, endothelial damage and inflammation biomarkers. J Nephrol; 2010 Jul-Aug;23(4):465-71
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  • To investigate the relationship, a 3-year prospective cohort study was conducted in 50 adult hemodialysis patients in NYHA class I-II who were free from diabetes and ischemic heart events.
  • Post-HD measurements of NT-proBNP, troponin T, and CRP maintained their prognostic value.
  • [MeSH-minor] Adult. Aged. Biomarkers. Cohort Studies. Female. Humans. Male. Middle Aged. Prognosis. Prospective Studies

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  • (PMID = 20540041.001).
  • [ISSN] 1121-8428
  • [Journal-full-title] Journal of nephrology
  • [ISO-abbreviation] J. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Endothelin-1; 0 / Peptide Fragments; 0 / Troponin I; 0 / Troponin T; 0 / pro-brain natriuretic peptide (1-76); 114471-18-0 / Natriuretic Peptide, Brain; 9007-41-4 / C-Reactive Protein
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33. Zurkovsky L, Brown SL, Korol DL: Estrogen modulates place learning through estrogen receptors in the hippocampus. Neurobiol Learn Mem; 2006 Nov;86(3):336-43
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  • Young adult female Sprague-Dawley rats were ovariectomized for 21 days and given systemic injections (0.1 ml) of sesame oil (OIL) or 10 microg of 17beta-estradiol-benzoate (E2), 48 and 24 h before being trained on a place task.

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  • (PMID = 16979357.001).
  • [ISSN] 1074-7427
  • [Journal-full-title] Neurobiology of learning and memory
  • [ISO-abbreviation] Neurobiol Learn Mem
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD07333
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 0 / Receptors, Estrogen; 22X328QOC4 / fulvestrant; 4TI98Z838E / Estradiol; 983-30-2 / estradiol-17 beta-benzoate
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34. Gimaev RKh, Ruzov VI, Razin VA, Boluchevskiĭ DN, Verushkina AS, Siapukova AA: [Effect of lipid metabolism disturbances on electrophysiologic heart remodeling in patients with hypertensive disease]. Klin Med (Mosk); 2009;87(11):30-3
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  • [Title] [Effect of lipid metabolism disturbances on electrophysiologic heart remodeling in patients with hypertensive disease].
  • The aim of the study was to evaluate effect of disturbed lipid metabolism on dispersion of QT interval, signal-averaged ECG characteristics, and cardiac rhythm variability as indicators of electrophysiological remodeling of myocardium in patients with HD.
  • The study included 111 patients aged 30-73 (mean 51.4 +/- 10.7) years with stage I-II HD.
  • [MeSH-minor] Adult. Aged. Blood Pressure / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Risk Factors

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  • (PMID = 20143562.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Lipids
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35. Jaber BL, Lee Y, Collins AJ, Hull AR, Kraus MA, McCarthy J, Miller BW, Spry L, Finkelstein FO, FREEDOM Study Group: Effect of daily hemodialysis on depressive symptoms and postdialysis recovery time: interim report from the FREEDOM (Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements) Study. Am J Kidney Dis; 2010 Sep;56(3):531-9
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  • STUDY DESIGN: The FREEDOM (Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements) Study is an ongoing prospective cohort study investigating the clinical and economic benefits of daily (6 times per week) hemodialysis (HD).
  • In this interim report, as part of an a priori planned analysis, we examine the long-term impact of daily HD on depressive symptoms, measured using the Beck Depression Inventory (BDI) survey, and postdialysis recovery time, measured using a previously validated questionnaire.
  • SETTING & PARTICIPANTS: Adult patients initiating daily HD with a planned 12-month follow-up.
  • Mean age was 52 years, 64% were men, 55% had an arteriovenous fistula, and 90% transitioned from in-center HD therapy.
  • CONCLUSIONS: Daily HD is associated with long-term improvement in depressive symptoms and postdialysis recovery time.

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  • [Copyright] Copyright (c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20673601.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Abramovici M; Addagatla S; Aronoff G; Daoui R; Elliott W; Galphin C; Gehr T; Gelman M; Govaerts T; Groggel G; Iannuzzelli A; Joist H; Kurian P; Lea J; Mohan C; Osman-Malik Y; Porile J; Rabideau D; Rozas V; Sevimli A; Sinsakul M; Schiller-Moran B; Solcher S; Szewc R; Williams A; Young B
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36. Ramezani A, Banifazl M, Eslamifar A, Aghakhani A: Serological pattern of anti-HBc alone infers occult hepatitis B virus infection in high-risk individuals in Iran. J Infect Dev Ctries; 2010 Oct;4(10):658-61
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  • METHODOLOGY: A total of 926 individuals were enrolled in this study, including 289 hemodialysis (HD) and 106 HIV-infected patients who were considered as a high-risk group and 531 blood donors who were considered as low-risk.
  • [MeSH-minor] Adult. Aged. DNA, Viral / blood. Female. HIV Infections / complications. Hepatitis B Surface Antigens / blood. Humans. Iran / epidemiology. Male. Middle Aged. Seroepidemiologic Studies

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  • [CommentIn] J Infect Dev Ctries. 2011 Feb;5(2):149-50 [21389597.001]
  • (PMID = 21045360.001).
  • [ISSN] 1972-2680
  • [Journal-full-title] Journal of infection in developing countries
  • [ISO-abbreviation] J Infect Dev Ctries
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Hepatitis B Antibodies; 0 / Hepatitis B Surface Antigens
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37. Steinman KJ, Mostofsky SH, Denckla MB: Toward a narrower, more pragmatic view of developmental dyspraxia. J Child Neurol; 2010 Jan;25(1):71-81
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  • We argue for the need to restrict use of the term developmental dyspraxia to describe impaired performance of skilled gestures, recognizing that, unlike acquired adult-onset apraxia, coexisting sensory and motor problems can also be present.

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  • (PMID = 20032517.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD-24061; United States / NINDS NIH HHS / NS / NS044850-01A2; United States / NINDS NIH HHS / NS / R01 NS048527-01A2; United States / NCRR NIH HHS / RR / UL1 RR025005; United States / NICHD NIH HHS / HD / P30 HD024061-17; United States / NINDS NIH HHS / NS / R01 NS043480-01A1; United States / NINDS NIH HHS / NS / NS043480-01A1; United States / NINDS NIH HHS / NS / K12 NS001692-09; United States / NIMH NIH HHS / MH / R01 MH085328; United States / NICHD NIH HHS / HD / P30 HD024061; United States / NIMH NIH HHS / MH / R01 MH078160; United States / NINDS NIH HHS / NS / K12 NS01692; United States / NINDS NIH HHS / NS / K02 NS044850; United States / NINDS NIH HHS / NS / R01 NS043480; United States / Autism Speaks / / AS2506; United States / NINDS NIH HHS / NS / K02 NS044850-01A2; United States / NIMH NIH HHS / MH / R01 MH078160-01A2; United States / NINDS NIH HHS / NS / K12 NS001692; United States / NCRR NIH HHS / RR / UL1-RR025005; United States / NICHD NIH HHS / HD / HD024061-17; United States / NCRR NIH HHS / RR / RR025005-02; United States / NIMH NIH HHS / MH / MH078160-01A2; United States / NINDS NIH HHS / NS / R01 NS048527; United States / NINDS NIH HHS / NS / NS001692-09; United States / NCRR NIH HHS / RR / UL1 RR025005-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 68
  • [Other-IDs] NLM/ NIHMS193792; NLM/ PMC2892896
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38. Lee SW, Park GH, Lee SY, Song JH, Kim MJ: Comparison of anthropometric data between end-stage renal disease patients undergoing hemodialysis and healthy adults in Korea. Yonsei Med J; 2005 Oct 31;46(5):658-66
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  • [Title] Comparison of anthropometric data between end-stage renal disease patients undergoing hemodialysis and healthy adults in Korea.
  • Protein-calorie malnutrition is prevalent in hemodialysis (HD) patients.
  • The prevalence of obesity in healthy Korean adults has increased rapidly during the last 10 years.
  • However, there are few large scale data collections available about the current weight status of Korean HD patients.
  • The weight statuses of 10,304 HD patients (data from the Insan Memorial Dialysis Registry 2002, Korean Society of Nephrology) were compared to those of 12,436 control subjects (age > 18) by using body mass index (BMI).
  • Weight status was assessed by WHO classification for Asian-Pacific region [underweight (UW): < 18.5; normal weight (NW): 18.5-22.9; overweight (OW): 23-24.9; obese (OB): 25-29.9; and extremely obese (EOB): > 30 kg/m2] in both the control and HD patients.
  • HD patients had significantly lower body weight and BMI than the controls in all age groups and in both sexes.
  • On the contrary, in HD patients, the proportions of NW and UW were large, up to more than 70%, and those of OW and OB were small in both sexes.
  • In each age group, UW was seen significantly more in the HD group than in the control group.
  • The 6th decade age group showed the highest prevalence ratio for UW in the HD group for both sexes, compared to the controls (Male: 17.33, Female: 17.68).
  • The percentages of UW were related to HD duration and age in both sexes.
  • In conclusion, Korean HD patients seem to have small proportions of OW and OB, compared to the general population, and protein-calorie malnutrition may still be an important nutritional condition.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Nutritional Status

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  • (PMID = 16259064.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2810572
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39. Szotek PP, Chang HL, Brennand K, Fujino A, Pieretti-Vanmarcke R, Lo Celso C, Dombkowski D, Preffer F, Cohen KS, Teixeira J, Donahoe PK: Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proc Natl Acad Sci U S A; 2008 Aug 26;105(34):12469-73
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  • Using BrdU incorporation and doxycycline inducible histone2B-green fluorescent protein pulse-chase techniques, we identify a label-retaining cell population in the coelomic epithelium of the adult mouse ovary as candidate somatic stem/progenitor cells.

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  • [ErratumIn] Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):19024
  • (PMID = 18711140.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD052701; United States / NCI NIH HHS / CA / 5R01CA017393-33; United States / NICHD NIH HHS / HD / HD052701-01A2; United States / NICHD NIH HHS / HD / R01 HD052701-01A2; United States / NCI NIH HHS / CA / 2T32CA071345-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins; G34N38R2N1 / Bromodeoxyuridine
  • [Other-IDs] NLM/ PMC2527935
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40. Fagugli RM, Ricciardi D, Rossi D, De Gaetano A, Taglioni C: Blood pressure assessment in haemodialysis patients: comparison between pre-dialysis blood pressure and ambulatory blood pressure measurement. Nephrology (Carlton); 2009 Apr;14(3):283-90
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  • AIM: Hypertension is common in haemodialysis (HD) patients.
  • BP variations between pre- and post-HD treatment, or between on-dialysis day and off-dialysis day, are common.
  • The aim of this study was to examine the possible differences between pre-HD office BP (OBP) levels, inter-HD (iHD) or HDday 24 h ambulatory BP measurement (ABPM) with 48 h ABPM, where the latter was considered the gold standard.
  • METHODS: 163 HD patients were studied.
  • BP was monitored consecutively for 48 h with a Takeda TM2421 device, then sub-analysed into two periods of 24 h: HD and iHD day.
  • An average of 12 sessions pre-HD OBP measurements was determined.
  • SBP and DBP are significantly higher on iHD day than on HD day: 141.2 1 20.8 versus 137.9 1 20.9, and 77.1 1 11.1 versus 76.1 1 10.9 (P < 0.01).
  • No differences of SBP night/day ratio were reported between 48 hABPM and iHD 24 h ABPM or HD 24 h ABPM.
  • The highest correlations were reported between 48 h SBP/DBP with iHD or HD 24 h ABPM (r 2 = 0.95, P < 0.001), while the lowest between 48 h SBP/DBP and OBP (r 2 = 0.40,P < 0.01, r 2 = 0.12, P < 0.01).
  • The narrowest limits of agreement using the Bland and Altman test were reported between 48 h SBP or DBP and 24 h iHD or HD day ABPM.
  • OBP measurement has a lower sensibility and specificity than 24 h ABPM, which remains a valid alternative approach to 48 h ABPM in HD patients.
  • [MeSH-minor] Adult. Aged. Female. Humans. Hypertension / diagnosis. Male. Middle Aged

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  • (PMID = 19444959.001).
  • [ISSN] 1440-1797
  • [Journal-full-title] Nephrology (Carlton, Vic.)
  • [ISO-abbreviation] Nephrology (Carlton)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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41. Shippy TD, Yeager SJ, Denell RE: The Tribolium spineless ortholog specifies both larval and adult antennal identity. Dev Genes Evol; 2009 Jan;219(1):45-51
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  • [Title] The Tribolium spineless ortholog specifies both larval and adult antennal identity.
  • Moreover, this knowledge applies mostly to adult structures, since Drosophila lacks external larval appendages.
  • In contrast to Drosophila, the red flour beetle, Tribolium castaneum, has both larval and adult antennae, which are very different from one another in morphology.
  • Here, we report that the Tribolium ortholog of spineless (Tc-ss) is required in both the larval and adult antennae.
  • Thus, the function of ss is conserved between Drosophila and Tribolium with respect to adult antennal specification and also between Tribolium larval and adult antennal development.
  • These results represent a first step in characterizing larval and adult antennal patterning in Tribolium, which should provide important insights into the evolution of insect antennal development.

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  • (PMID = 19030877.001).
  • [ISSN] 1432-041X
  • [Journal-full-title] Development genes and evolution
  • [ISO-abbreviation] Dev. Genes Evol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD029594-15; United States / NICHD NIH HHS / HD / R01 HD029594-08; United States / NICHD NIH HHS / HD / HD029594-09; United States / NICHD NIH HHS / HD / R01HD029594; United States / NICHD NIH HHS / HD / HD029594-10; United States / NICHD NIH HHS / HD / R01 HD029594-16; United States / NICHD NIH HHS / HD / R01 HD029594-09; United States / NICHD NIH HHS / HD / R01 HD029594; United States / NICHD NIH HHS / HD / HD029594-08; United States / Howard Hughes Medical Institute / / ; United States / NICHD NIH HHS / HD / R01 HD029594-10; United States / NICHD NIH HHS / HD / R01 HD029594-18
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Insect Proteins; 0 / Receptors, Aryl Hydrocarbon
  • [Other-IDs] NLM/ NIHMS75424; NLM/ PMC2605184
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42. Kim JS, Kondratyev A, Tomita Y, Gale K: Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain. Epilepsia; 2007;48 Suppl 5:19-26
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  • In view of our previously findings of neuroprotective actions of repeated seizures in the adult brain, we also examined repeated seizures for a possible antiapoptotic action in the infant rat.

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  • [ErratumIn] Epilepsia. 2007 Dec;48(12):2379
  • (PMID = 17910577.001).
  • [ISSN] 0013-9580
  • [Journal-full-title] Epilepsia
  • [ISO-abbreviation] Epilepsia
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / MH 02040; United States / NINDS NIH HHS / NS / NS20576; United States / NICHD NIH HHS / HD / U10 HD047890
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 230447L0GL / etiracetam; 6LR8C1B66Q / Dizocilpine Maleate; ZH516LNZ10 / Piracetam
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43. Abe Y, Eto S, Matsumae T, Ogahara S, Murata T, Watanabe M, Nakashima H, Saito T: The proportion and metabolic effects of adiponectin multimeric isoforms in patients with chronic kidney disease on maintenance hemodialysis. Ren Fail; 2010;32(7):849-54
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  • [Title] The proportion and metabolic effects of adiponectin multimeric isoforms in patients with chronic kidney disease on maintenance hemodialysis.
  • Although it has been reported that adiponectin has the favorable metabolic properties for humans, the roles of these multimers in the patients with the end-stage renal disease (ESRD) were unidentified.
  • We determined the level of total and multimeric adiponectin in 71 patients with nondiabetic ESRD treated with hemodialysis (HD) using a commercially available kit of enzyme-linked immunosorbent assay (ELISA).
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Protein Isoforms. Protein Multimerization

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  • (PMID = 20662699.001).
  • [ISSN] 1525-6049
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Protein Isoforms
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44. Rao R, Sperr D, Ennis K, Tran P: Postnatal age influences hypoglycemia-induced poly(ADP-ribose) polymerase-1 activation in the brain regions of rats. Pediatr Res; 2009 Dec;66(6):642-7
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  • Poly(ADP-ribose) polymerase-1 (PARP-1) overactivation plays a significant role in hypoglycemia-induced brain injury in adult rats.
  • To determine the influence of postnatal age on PARP-1 activation, developing and adult male rats were subjected to acute hypoglycemia of equivalent severity and duration.
  • Compared with the control group, PARP-1 expression increased in the cerebral cortex of adult rats 24 h posthypoglycemia, but not at 0 h, and it was accompanied by increased number of PAR-positive cells.
  • Aifm1, Nfkb1, Casp3, and Bcl2 expressions also increased in the cerebral cortex of adult rats 24 h posthypoglycemia.

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  • (PMID = 19687776.001).
  • [ISSN] 1530-0447
  • [Journal-full-title] Pediatric research
  • [ISO-abbreviation] Pediatr. Res.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD047276-03; United States / NICHD NIH HHS / HD / K08 HD047276; United States / NICHD NIH HHS / HD / HD047276; United States / NICHD NIH HHS / HD / K08 HD047276-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Inducing Factor; 0 / DNA Primers; 0 / NF-kappa B; EC 2.4.2.30 / Parp1 protein, rat; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspase 3
  • [Other-IDs] NLM/ NIHMS149425; NLM/ PMC2796291
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45. Kanaan A, Douglas RM, Alper SL, Boron WF, Haddad GG: Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse. Am J Physiol Regul Integr Comp Physiol; 2007 Sep;293(3):R1294-302
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  • [Title] Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.
  • Several pulmonary and neurological conditions, both in the newborn and adult, result in hypercapnia.
  • Neonatal and adult CD-1 mice were exposed to either 8% or 12% CO(2) for 2 wk.
  • Chronic CO(2) increased the expression of the sodium hydrogen exchanger 1 (NHE1) and electroneutral sodium bicarbonate cotransporter (NBCn1) in the cerebral cortex, heart, and kidney of neonatal but not adult mice.
  • CO(2) increased the expression of electrogenic NBC (NBCe1) in the neonatal but not the adult mouse heart and kidney.
  • Hypercapnia decreased the expression of anion exchanger 3 (AE3) in both the neonatal and adult brain but increased AE3 expression in the neonatal heart.
  • [MeSH-minor] Animals. Anion Transport Proteins / metabolism. Antibodies, Blocking / pharmacology. Antiporters / metabolism. Blotting, Western. Body Weight / physiology. Brain Chemistry / physiology. Cation Transport Proteins / antagonists & inhibitors. Cation Transport Proteins / biosynthesis. Chronic Disease. Kidney / metabolism. Male. Membrane Proteins / antagonists & inhibitors. Membrane Proteins / biosynthesis. Mice. Myocardium / metabolism. SLC4A Proteins. Sodium-Bicarbonate Symporters / metabolism. Sodium-Hydrogen Antiporter / antagonists & inhibitors. Sodium-Hydrogen Antiporter / biosynthesis

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  • (PMID = 17652362.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD 032573; United States / NINDS NIH HHS / NS / NS 037756; United States / NINDS NIH HHS / NS / NS 18400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anion Transport Proteins; 0 / Antibodies, Blocking; 0 / Antiporters; 0 / Carrier Proteins; 0 / Cation Transport Proteins; 0 / Membrane Proteins; 0 / SLC4A Proteins; 0 / Slc9a1 protein, mouse; 0 / Sodium-Bicarbonate Symporters; 0 / Sodium-Hydrogen Antiporter
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46. Soldin OP, Aschner M: Effects of manganese on thyroid hormone homeostasis: potential links. Neurotoxicology; 2007 Sep;28(5):951-6
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  • Environmental or occupational exposure to high levels of manganese can cause a neuropathy resembling idiopathic Parkinson's disease, commonly referred to as manganism.
  • Manganism and Parkinson's disease are both characterized by motor deficits and damage to nuclei of the basal ganglia, particularly the substantia nigra, with altered dopamine (and its metabolites) contributing to these disorders.
  • While the effects of manganese in adult populations are relatively well documented, comprehensive data on its neurodevelopmental effects are sparse.

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  • (PMID = 17576015.001).
  • [ISSN] 0161-813X
  • [Journal-full-title] Neurotoxicology
  • [ISO-abbreviation] Neurotoxicology
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R01 ES010563-07; United States / NICHD NIH HHS / HD / 5U10HD047890-03; United States / NICHD NIH HHS / HD / U10 HD047890; United States / NIEHS NIH HHS / ES / ES010563-07; United States / NIEHS NIH HHS / ES / ES10563; United States / NIEHS NIH HHS / ES / R01 ES010563
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Thyroid Hormones; 42Z2K6ZL8P / Manganese; VTD58H1Z2X / Dopamine
  • [Number-of-references] 51
  • [Other-IDs] NLM/ NIHMS33068; NLM/ PMC2067987
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47. Chen W, Srinivasan SR, Berenson GS: Amplification of the association between birthweight and blood pressure with age: the Bogalusa Heart Study. J Hypertens; 2010 Oct;28(10):2046-52
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  • CONCLUSION: These findings on the potentiating effect of increasing age on the birthweight-BP relationship suggest that the fetal programming and the increasing cumulative burden with age of unhealthy lifestyle behaviors affect the development of adult hypertension in a synergistic manner.

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  • (PMID = 20616754.001).
  • [ISSN] 1473-5598
  • [Journal-full-title] Journal of hypertension
  • [ISO-abbreviation] J. Hypertens.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R03 HD062783; United States / NICHD NIH HHS / HD / R03 HD061437-02; United States / NICHD NIH HHS / HD / HD062783-02; United States / NIA NIH HHS / AG / R01 AG016592; United States / NICHD NIH HHS / HD / HD-062783; United States / NIA NIH HHS / AG / AG-16592; United States / NICHD NIH HHS / HD / R03 HD061437; United States / NICHD NIH HHS / HD / HD061437-02; United States / NICHD NIH HHS / HD / R03 HD062783-02; United States / NICHD NIH HHS / HD / HD-061437
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS294512; NLM/ PMC3105358
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48. Biglan KM, Ross CA, Langbehn DR, Aylward EH, Stout JC, Queller S, Carlozzi NE, Duff K, Beglinger LJ, Paulsen JS, PREDICT-HD Investigators of the Huntington Study Group: Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study. Mov Disord; 2009 Sep 15;24(12):1763-72
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  • [Title] Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study.
  • The PREDICT-HD study seeks to identify clinical and biological markers of Huntington's disease in premanifest individuals who have undergone predictive genetic testing.
  • Elevated total motor scores at baseline were associated with higher genetic probability of disease diagnosis in the near future (partial R(2) 0.14, P < 0.0001) and smaller striatal volumes (partial R(2) 0.15, P < 0.0001).
  • Even in this premanifest population, subtle motor abnormalities were associated with a higher probability of disease diagnosis and smaller striatal volumes.

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  • (PMID = 19562761.001).
  • [ISSN] 1531-8257
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS040068-09; United States / NINDS NIH HHS / NS / NS040068-09; United States / NINDS NIH HHS / NS / R01 NS040068; United States / NINDS NIH HHS / NS / NS40068; United States / NCATS NIH HHS / TR / UL1 TR000442; United States / NCRR NIH HHS / RR / S10 RR023392; United States / NCATS NIH HHS / TR / UL1 TR000040
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS274263; NLM/ PMC3048804
  • [Investigator] Ames D; Chiu E; Chua P; Yastrubetskaya O; Dingjan P; Drpaer K; Georgiou-Karistianis N; Goh A; Komiti A; Lemmon C; Paulson H; Bastic K; Conybeare R; Humphreys C; Nopoulos P; Rodnitzky R; Uc E; Beglinger L; Duff K; Magnotta VA; Doucette N; French S; Juhl A; Kuburas H; Mikos A; Reese B; Turner B; Van Der Heiden S; Raymond L; Decolongon J; Rosenblatt A; Ross C; Agarwal A; Gourley L; Shpritz B; Wajda K; Bakker A; Miller R; Mallonee W; Suter G; Palmer D; Addison J; Jones R; Harrison J; Greenamyre JT; Testa C; McCusker E; Griffith J; Bibb B; Hayes C; Richardson K; Samii A; Lipe H; Bird T; Logsdon R; Weaver K; Field K; Landwehrmeyer BG; Barth K; Niess A; Trautmann S; Ecker D; Held C; Guttman M; Elliott S; Fonariov Z; Giambattista C; Russell S; Sebastian J; Sethna R; Ip R; Shaddick D; Sheinberg A; Stober J; Perlman S; Carroll R; Johnson A; Jackson G; Geschwind MD; Guzijan M; Rose K; Warner T; Kloppel S; Burrows M; Andrews T; Rosser E; Tabrizi S; Golding C; Barker RA; Mason S; Smith E; Rosser A; Naji J; Price K; Handley OJ; Suchowersky O; Furtado S; Klimek ML; Kirstein D; Rosas D; Bennett M; Frishman J; Kaneko Y; Landau T; Lausier M; Muir L; Murphy L; Young A; Skeuse C; Balkema N; Hoogenboom W; Leveroni C; Sherman J; Zaleta A; Panegyres P; Connor C; Woodman M; Zombor R; Perlmutter J; Barton S; Kavanaugh M; Simpson SA; Keenan G; Ure A; Summers F; Craufurd D; Macleod R; Sollom A; Howard E; Quaid K; Wesson M; Wojcieszek J; Beristain X; Mazzoni P; Marder K; Williamson J; Moskowitz C; Wasserman P; Como P; Chesire A; Hickey C; Zimmerman C; Couniham T; Marshall F; Burton C; Wodarski M; Wheelock V; Tempkin T; Baynes K; Jankovic J; Hunter C; Ondo W; Martin C; Garcia de Yebenes J; Bascunana Garde M; Fatas M; Schwartz C; Fernandez Urdanibia J; Gonzalez Gordaliza C; Seeberger L; Diamond A; Judd D; Kasunic TL; Mellick L; Miracle D; Montellano S; Kumar R; Schneiders J; Nance M; Radtke D; Norberg D; Tupper D; Martin W; King P; Wieler M; Foster S; Sran S; Dubinsky R; Gray C; Switzer P; Paulsen J; Langbehn D; Johnson H; Aylward E; Biglan K; Kieburtz K; Oakes D; Shoulson I; Guttman M; Hayden M; Landwehrmeyer BG; Nance M; Ross C; Stout J; Blanchard S; Anderson C; Dudler A; Penziner E; Leserman A; Ludwig B; McAreavy B; Murray G; Nehl C; Vik S; Wang C; Werling C; Bourgeois K; Covert C; Daigneault S; Julian-Baros E; Meyers K; Rothenburgh K; Olsen B; Orme C; Ross T; Weber J; Zhao H; Stout JC; Queller S; Johnson SA; Campbell JC; Peters E; Carlozzi NE; Green T; Swain SN; Caughlin D; Ward-Bluhm B; Whitlock K; Paulsen J; Penziner E; Vik S; Agarwal A; Barnes A; Suter G; Jones R; Griffith J; Lipe H; Barth K; Fox M; Guzijan M; Zanko A; Naji J; Zombor R; Kavanaugh M; Chesire A; Julian-Baros E; Kayson E; Tempkin T; Nance M; Quaid K; Stout J; Paulsen J; Coryell W; Ross C; Kayson E; Shinaman A; Tempkin T; Nance M; Quaid K; Stout J; Erwin S
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49. Ciriaco P, Casiraghi M, Melloni G, Carretta A, Libretti L, Augello G, Zannini P: Pulmonary resection for non-small-cell lung cancer in patients on hemodialysis: clinical outcome and long-term results. World J Surg; 2005 Nov;29(11):1516-9
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  • Patients on hemodialysis (HD) who undergo surgery represent a high risk group requiring careful perioperative management to avoid electrolyte imbalance and hemodynamic instability.
  • The aim of the study was to analyze the postoperative outcome in terms of complications and survival of a group of patients on HD who had undergone pulmonary resection for non-small cell lung cancer (NSCLC).
  • Six patients on HD underwent seven pulmonary resections at our institution from 1998 to 2003.
  • The underlying kidney disease was nephrosclerosis in two patients and glomerulonephritis in four.
  • The remaining five patients are currently alive with no evidence of disease.
  • Patients on HD who undergo lung resection have a high rate of postoperative complications.
  • Although the underlying disease influences long-term survival, radical lung resection in NSCLC patients is recommended in selected cases.
  • [MeSH-minor] Adult. Aged. Blood Urea Nitrogen. Creatine / blood. Female. Humans. Male. Treatment Outcome


50. Pourmand G, Emamzadeh A, Moosavi S, Mehrsai A, Taherimahmoudi M, Nikoobakht M, Saraji A, Salem S: Does renal transplantation improve erectile dysfunction in hemodialysed patients? What is the role of associated factors? Transplant Proc; 2007 May;39(4):1029-32
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  • OBJECTIVE: To assess the effect of successful renal transplantation on improvement of erectile function in hemodialysis (HD) patients and the relationship between the degree of patient response and other factors.
  • MATERIALS AND METHODS: From September 2002 to November 2005, erectile function of 64 patients on HD for at least 6 months was evaluated pretransplantation and 6 months posttransplantation by International Index of Erectile Function, version 5 (IIEF-5).
  • Sixty four age-matched persons without renal impairment were enrolled as control group to compare erectile dysfunction (ED) prevalence with the HD group.
  • We evaluated duration of HD, age, and site of arterial anastomosis.
  • RESULTS: The prevalence of ED in HD patients was 87.5%.
  • There was no relationship between the duration of dialysis and the severity of ED in HD group.
  • [MeSH-minor] Adult. Humans. Living Donors. Male. Prospective Studies. Renal Dialysis


51. Kanbay M, Delibasi T, Kaya A, Aydogan T, Koca C, Akcay A, Duranay M, Yigitoglu R: Effect of dialysis type on serum lipids, apolipoproteins, and lipoproteins. Ren Fail; 2006;28(7):567-71
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  • AIM: Dyslipidemia is common among patients with end-stage renal disease, whether treated by hemodialysis (HD) or peritoneal dialysis (PD).
  • MATERIALS AND METHODS: This study enrolled 40 HD patients (20 men and 20 women, aged 48.1 +/- 17.6 years) and 69 PD patients (35 men and 34 women, aged 45.2 +/- 16.3 years).
  • Serum lipid profile including total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), triglyceride (TG), Apo(a), Apo(b), and Lp(a) were determined in HD and PD patients.
  • RESULTS: No significant differences in TC, LDL-C, HDL-C, TG, Apo(a), Apo(b), or Lp(a) serum levels were found between HD and PD patients.
  • Serum TC, LDL-C, HDL-C, TG, Apo(a), Apo(b), and Lp(a) in HD and PD patients were 172.2 +/- 42.7 (mg/dL) vs. 181.0 +/- 53.0 (mg/dL), 97.2 +/- 36.2 (mg/dL) vs. 101.4 +/- 33.6 (mg/dL), 45.3 +/- 11.9 (mg/dL) vs. 41.4 +/- 11.1 (mg/dL), 144.7 +/- 71.8 (mg/dL) vs. 173.0 +/- 76.8 (mg/dL), 1.2 +/- 0.5 (g/L) vs. 1.0 +/- 0.2 (g/L), 0.9 +/- 0.3 (g/L) vs. 1.2 +/- 0.3 (g/L), and 43.1 +/- 40.6 (mg/dL) vs. 46.0 +/- 42.7 (mg/dL), respectively.
  • CONCLUSION: The results of this study show that the maintenance CAPD treatment is associated with more pronounced alterations of the lipoproteins and lipid metabolism than those observed during HD treatment.
  • [MeSH-minor] Adult. Aged. Apolipoproteins A / blood. Apolipoproteins B / blood. Cholesterol / blood. Female. Humans. Lipoprotein(a) / blood. Lipoproteins, HDL / blood. Lipoproteins, LDL / blood. Male. Middle Aged. Triglycerides / blood

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  • (PMID = 17050239.001).
  • [ISSN] 0886-022X
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins; 0 / Apolipoproteins A; 0 / Apolipoproteins B; 0 / Lipids; 0 / Lipoprotein(a); 0 / Lipoproteins; 0 / Lipoproteins, HDL; 0 / Lipoproteins, LDL; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
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52. Espinosa-Jeffrey A, Hitoshi S, Zhao P, Awosika O, Agbo C, Olaniyan E, Garcia J, Valera R, Thomassian A, Chang-Wei R, Yamaguchi M, de Vellis J, Ikenaka K: Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpression. J Neurosci Res; 2010 Jun;88(8):1682-94
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  • [Title] Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpression.
  • Two types of interventions to remyelinate the adult demyelinated central nervous system were investigated in heterozygous transgenic mice overexpressing the proteolipid protein gene.
  • [MeSH-minor] Amidines / metabolism. Animals. Cell Movement / drug effects. Cells, Cultured. Corpus Callosum / metabolism. Corpus Callosum / transplantation. Culture Media, Conditioned / pharmacology. Disease Models, Animal. Dose-Response Relationship, Drug. Exploratory Behavior / physiology. Gangliosides / metabolism. Gene Expression Regulation / drug effects. Green Fluorescent Proteins / genetics. Hindlimb / drug effects. Hindlimb / physiopathology. Intercellular Signaling Peptides and Proteins / pharmacology. Intermediate Filament Proteins / genetics. Mice. Mice, Transgenic. Microscopy, Confocal / methods. Myelin Basic Protein / metabolism. Nerve Tissue Proteins / genetics. Nestin. Neurofilament Proteins / metabolism. Neuroglia / chemistry. Time Factors

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  • (PMID = 20127853.001).
  • [ISSN] 1097-4547
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD-04612; United States / NICHD NIH HHS / HD / HD-06576
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amidines; 0 / Culture Media, Conditioned; 0 / Gangliosides; 0 / Intercellular Signaling Peptides and Proteins; 0 / Intermediate Filament Proteins; 0 / Myelin Basic Protein; 0 / Myelin Proteolipid Protein; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / Neurofilament Proteins; 0 / Plp1 protein, mouse; 0 / diamidino compound 253-50; 0 / ganglioside A2B5; 147336-22-9 / Green Fluorescent Proteins
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53. Desilva TM, Kinney HC, Borenstein NS, Trachtenberg FL, Irwin N, Volpe JJ, Rosenberg PA: The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter. J Comp Neurol; 2007 Apr 20;501(6):879-90
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  • Immunoblotting demonstrated that EAAT2 protein was highly expressed in early development relative to adult values.
  • [MeSH-minor] Adult. Aged. Critical Period (Psychology). Excitatory Amino Acid Transporter 1 / genetics. Excitatory Amino Acid Transporter 1 / metabolism. Excitatory Amino Acid Transporter 3 / genetics. Excitatory Amino Acid Transporter 3 / metabolism. Fetus / metabolism. Gene Expression Regulation, Developmental / physiology. Humans. Immunohistochemistry. Infant, Newborn. Middle Aged. RNA, Messenger / analysis. Tissue Distribution

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17311320.001).
  • [ISSN] 0021-9967
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD18655; United States / NINDS NIH HHS / NS / NS07473; United States / NINDS NIH HHS / NS / NS38475; United States / NINDS NIH HHS / NS / NS40753; United States / NINDS NIH HHS / NS / NS41883
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Transporter 1; 0 / Excitatory Amino Acid Transporter 2; 0 / Excitatory Amino Acid Transporter 3; 0 / RNA, Messenger
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54. Fletcher JM, Green JC, Neidell MJ: Long term effects of childhood asthma on adult health. J Health Econ; 2010 May;29(3):377-87
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  • [Title] Long term effects of childhood asthma on adult health.
  • In this paper, we estimate the relationship between childhood asthma and several outcomes as a young adult.
  • In our preferred specification, we find substantial long term impacts of childhood asthma on general health status, obesity, and missed work and school days as a young adult.
  • Broadly, our findings contribute to the growing literature in social sciences on the impacts of early life health conditions on later life health and social outcomes and suggest early treatment of asthma may have long-run benefits on young adult health and socioeconomic outcomes.
  • [MeSH-minor] Age of Onset. Child. Cross-Sectional Studies. Female. Health Surveys. Humans. Longitudinal Studies. Male. Obesity / complications. Siblings. Sick Leave. Time Factors. United States. Young Adult

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  • (PMID = 20394999.001).
  • [ISSN] 1879-1646
  • [Journal-full-title] Journal of health economics
  • [ISO-abbreviation] J Health Econ
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P01-HD31921
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
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55. Sozda CN, Hoffman AN, Olsen AS, Cheng JP, Zafonte RD, Kline AE: Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury. J Neurotrauma; 2010 Jun;27(6):1047-57
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  • To clarify this ambiguity, anesthetized adult male rats were subjected to either a controlled cortical impact or sham injury, and then were randomly assigned to five different housing paradigms:.

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  • (PMID = 20334496.001).
  • [ISSN] 1557-9042
  • [Journal-full-title] Journal of neurotrauma
  • [ISO-abbreviation] J. Neurotrauma
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD046700; United States / NINDS NIH HHS / NS / NS060005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2943502
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56. Ferreira IL, Nascimento MV, Ribeiro M, Almeida S, Cardoso SM, Grazina M, Pratas J, Santos MJ, Januário C, Oliveira CR, Rego AC: Mitochondrial-dependent apoptosis in Huntington's disease human cybrids. Exp Neurol; 2010 Apr;222(2):243-55
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  • [Title] Mitochondrial-dependent apoptosis in Huntington's disease human cybrids.
  • We investigated the involvement of mitochondrial-dependent apoptosis in Huntington's disease (HD) vs. control (CTR) cybrids, obtained from the fusion of human platelets with mitochondrial DNA-depleted NT2 cells, and further exposed to 3-nitropropionic acid (3-NP) or staurosporine (STS).
  • Untreated HD cybrids did not exhibit significant modifications in the activity of mitochondrial respiratory chain complexes I-IV or in mtDNA sequence variations suggestive of a primary role in mitochondrial susceptibility in the subpopulation of HD carriers studied.
  • However, a slight decrease in mitochondrial membrane potential and increased formation of intracellular hydroperoxides was observed in HD cybrids under basal conditions.
  • Furthermore, apoptotic nuclei morphology and a moderate increase in caspase-3 activation, as well as increased levels of superoxide ions and hydroperoxides were observed in HD cybrids upon 3-NP or STS treatment.
  • 3-NP-evoked apoptosis in HD cybrids involved cytochrome c and AIF release from mitochondria, which was associated with mitochondrial Bax translocation.
  • Additionally, increased mitochondrial Bim and Bak levels, and a slight release of cytochrome c in untreated HD cybrids may help to explain their moderate susceptibility to mitochondrial-dependent apoptosis.
  • [MeSH-major] Apoptosis / physiology. Huntington Disease / pathology. Huntington Disease / physiopathology. Mitochondria / metabolism. Multienzyme Complexes / metabolism
  • [MeSH-minor] Adult. Analysis of Variance. Apoptosis Inducing Factor / metabolism. Apoptosis Regulatory Proteins / metabolism. Case-Control Studies. Caspase 3 / metabolism. Cell Line, Tumor. Citrate (si)-Synthase / metabolism. DNA, Mitochondrial / metabolism. Dose-Response Relationship, Drug. Electron Transport Complex III / metabolism. Electron Transport Complex IV / metabolism. Enzyme Inhibitors / pharmacology. Gene Expression Regulation / drug effects. Gene Expression Regulation / genetics. Humans. Intracellular Fluid / metabolism. L-Lactate Dehydrogenase / metabolism. Membrane Potential, Mitochondrial / drug effects. Membrane Potential, Mitochondrial / genetics. Membrane Potential, Mitochondrial / physiology. Membrane Proteins / metabolism. Nitrobenzoates / pharmacology. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Reactive Oxygen Species / metabolism. Staurosporine / pharmacology. Subcellular Fractions / metabolism. Superoxides / metabolism. Teratocarcinoma. Time Factors. Trinucleotide Repeat Expansion / genetics. bcl-2 Homologous Antagonist-Killer Protein / metabolism. bcl-2-Associated X Protein / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20079354.001).
  • [ISSN] 1090-2430
  • [Journal-full-title] Experimental neurology
  • [ISO-abbreviation] Exp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Inducing Factor; 0 / Apoptosis Regulatory Proteins; 0 / Bcl-2-like protein 11; 0 / DNA, Mitochondrial; 0 / Enzyme Inhibitors; 0 / Membrane Proteins; 0 / Multienzyme Complexes; 0 / Nitrobenzoates; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Reactive Oxygen Species; 0 / bcl-2 Homologous Antagonist-Killer Protein; 0 / bcl-2-Associated X Protein; 11062-77-4 / Superoxides; 121-92-6 / 3-nitrobenzoic acid; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 1.10.2.2 / Electron Transport Complex III; EC 1.9.3.1 / Electron Transport Complex IV; EC 2.3.3.1 / Citrate (si)-Synthase; EC 3.4.22.- / Caspase 3; H88EPA0A3N / Staurosporine
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57. Paiardini M, Hoffman J, Cervasi B, Ortiz AM, Stroud F, Silvestri G, Wilson ME: T-cell phenotypic and functional changes associated with social subordination and gene polymorphisms in the serotonin reuptake transporter in female rhesus monkeys. Brain Behav Immun; 2009 Feb;23(2):286-93
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  • The present study evaluated how immune function was altered by the interaction of in polymorphisms in the gene that encodes the serotonin reuptake transporter (5HTT) and the psychosocial stress imposed by social subordination in adult female rhesus monkeys.
  • These data underscore the importance for considering gene polymorphisms that influence emotional reactivity to better understand susceptibility to disease.

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  • (PMID = 18992804.001).
  • [ISSN] 1090-2139
  • [Journal-full-title] Brain, behavior, and immunity
  • [ISO-abbreviation] Brain Behav. Immun.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD046501; United States / NCRR NIH HHS / RR / RR000165-485911; United States / NICHD NIH HHS / HD / R01 HD046501-03; United States / NCRR NIH HHS / RR / P51 RR000165; United States / NICHD NIH HHS / HD / HD46501; United States / NCRR NIH HHS / RR / P51 RR000165-485911; United States / NCRR NIH HHS / RR / RR00165
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Antigens, CD4; 0 / Antigens, CD8; 0 / Glucocorticoids; 0 / Serotonin Plasma Membrane Transport Proteins
  • [Other-IDs] NLM/ NIHMS95919; NLM/ PMC2654552
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58. Harford TC, Yi HY, Faden VB, Chen CM: The dimensionality of DSM-IV alcohol use disorders among adolescent and adult drinkers and symptom patterns by age, gender, and race/ethnicity. Alcohol Clin Exp Res; 2009 May;33(5):868-78
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  • [Title] The dimensionality of DSM-IV alcohol use disorders among adolescent and adult drinkers and symptom patterns by age, gender, and race/ethnicity.
  • The purpose of this study is to assess the DSM-IV AUD symptom criteria as reported by adolescent and adult drinkers in a single representative sample of the U.S. population aged 12 years and older.
  • This design avoids potential confounding due to differences in survey methodology when comparing adolescents and adults from different surveys.
  • CONCLUSIONS: Findings from the present study do not provide support for the 2 separate DSM-IV diagnoses of alcohol abuse and dependence among either adolescents or adults.

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  • (PMID = 19320629.001).
  • [ISSN] 1530-0277
  • [Journal-full-title] Alcoholism, clinical and experimental research
  • [ISO-abbreviation] Alcohol. Clin. Exp. Res.
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / AA032007; United States / NICHD NIH HHS / HD / N01AA32007; United States / NIAAA NIH HHS / AA / AA 32007; United States / NIAAA NIH HHS / AA / N01 AA032007
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS235754; NLM/ PMC4664203
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59. Cheatham RA, Roberts SB, Das SK, Gilhooly CH, Golden JK, Hyatt R, Lerner D, Saltzman E, Lieberman HR: Long-term effects of provided low and high glycemic load low energy diets on mood and cognition. Physiol Behav; 2009 Sep 07;98(3):374-9
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  • Subjects were 42 healthy overweight adults (age 35+/-5 years; BMI 27.8+/-1.6 kg/m(2)) with a mean weight loss of 8.7+/-5.0% that did not differ significantly by diet randomization.
  • These findings suggest a negative effect of an HG weight loss diet on sub-clinical depression but, in contrast to a previous suggestion, provide no support for differential effects of LG versus HD diets on cognitive performance.
  • [MeSH-minor] Adult. Female. Humans. Male. Time Factors. Weight Loss

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  • (PMID = 19576915.001).
  • [ISSN] 1873-507X
  • [Journal-full-title] Physiology & behavior
  • [ISO-abbreviation] Physiol. Behav.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK040561; United States / NIDDK NIH HHS / DK / T32 DK62032-11; United States / NIA NIH HHS / AG / U01 AG020480; United States / NIA NIH HHS / AG / U01-AG20480; United States / NIDDK NIH HHS / DK / T32 DK062032; United States / NIDDK NIH HHS / DK / K23 DK061506; United States / NIDDK NIH HHS / DK / P30 DK040561-14; United States / NIDDK NIH HHS / DK / K23 DK61506; United States / NIA NIH HHS / AG / U01 AG020480-01
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Carbohydrates
  • [Other-IDs] NLM/ NIHMS142087; NLM/ PMC2775046
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60. Eisner-Janowicz I, Barbay S, Hoover E, Stowe AM, Frost SB, Plautz EJ, Nudo RJ: Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey. J Neurophysiol; 2008 Sep;100(3):1498-512
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  • In the present study in adult squirrel monkeys, intracortical microstimulation (ICMS) techniques were used to monitor changes in representational maps of the distal forelimb in the supplementary motor area (SMA) after a unilateral ischemic infarct of primary motor (M1) and premotor distal forelimb representations (DFLs).

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  • (PMID = 18596180.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD-02528; United States / NINDS NIH HHS / NS / NS-30853
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2544457
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61. Yin D, Zhang JH: Delayed and multiple hyperbaric oxygen treatments expand therapeutic window in rat focal cerebral ischemic model. Neurocrit Care; 2005;2(2):206-11
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  • Adult male Sprague-Dawley rats were subjected to middle cerebral artery occlusion/reperfusion (MCAO/R) and were subsequently exposed to HBO (2.5 atmospheres absolute [ATA]) for 2 hours per day.
  • [MeSH-minor] Animals. Cerebral Cortex / pathology. Disease Models, Animal. Male. Rats. Rats, Sprague-Dawley. Reperfusion. Time Factors

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  • (PMID = 16159067.001).
  • [ISSN] 1541-6933
  • [Journal-full-title] Neurocritical care
  • [ISO-abbreviation] Neurocrit Care
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD43120; United States / NINDS NIH HHS / NS / NS43338
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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62. Wolff EF, Wolff AB, Hongling Du, Taylor HS: Demonstration of multipotent stem cells in the adult human endometrium by in vitro chondrogenesis. Reprod Sci; 2007 Sep;14(6):524-33
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  • [Title] Demonstration of multipotent stem cells in the adult human endometrium by in vitro chondrogenesis.
  • Endometrial tissue was obtained from reproductive-aged women undergoing surgery for benign disease, from which monolayer endometrial stromal cell (ESC), myometrial, fibroid, fallopian tube, and uterosacral ligament tissue cultures were generated.
  • [MeSH-major] Adult Stem Cells. Cell Differentiation. Cell Lineage. Chondrocytes. Chondrogenesis. Endometrium / cytology. Multipotent Stem Cells
  • [MeSH-minor] Adult. Cells, Cultured. Collagen Type II / metabolism. Dexamethasone / pharmacology. Female. Glucocorticoids / pharmacology. Glycosaminoglycans / metabolism. Humans. Time Factors. Transforming Growth Factor beta2 / metabolism. Transforming Growth Factor beta3 / metabolism

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  • (PMID = 17959881.001).
  • [ISSN] 1933-7205
  • [Journal-full-title] Reproductive sciences (Thousand Oaks, Calif.)
  • [ISO-abbreviation] Reprod Sci
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12 HD00849; United States / NICHD NIH HHS / HD / R01 HD36887; United States / NICHD NIH HHS / HD / U54 HD052668
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type II; 0 / Glucocorticoids; 0 / Glycosaminoglycans; 0 / Transforming Growth Factor beta2; 0 / Transforming Growth Factor beta3; 7S5I7G3JQL / Dexamethasone
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63. Raad II, Hanna HA, Boktour M, Jiang Y, Torres HA, Afif C, Kontoyiannis DP, Hachem RY: Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin. Leukemia; 2008 Mar;22(3):496-503
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  • To investigate novel antifungal agents, we compared 53 patients who received posaconazole salvage therapy to 52 contemporary control patients who received high-dose lipid formulation of amphotericin B (HD-LPD/AMB at > or = 7.5 mg kg(-1) per day) and 38 other control patients who received caspofungin plus HD-LPD/AMB.
  • The overall response rate to salvage therapy was 40% for posaconazole, 8% for HD-LPD/AMB (P < or = 0.001) and 11% for combination therapy (P < 0.002).
  • Aspergillosis contributed to the death of 40% of posaconazole group, 65% of the HD-LPD/AMB group and 68% of the combination group (P < or = 0.008).
  • HD-LPD/AMB alone or in combination was associated with a significantly higher rate of nephrotoxicity (P < or = 0.02) and hepatotoxicity (P < 0.03).
  • In conclusion, posaconazole salvage therapy demonstrated greater efficacy and safety than HD-LPD/AMB alone or in combination with caspofungin in the salvage therapy of invasive aspergillosis in hematologic malignancy.
  • [MeSH-minor] Adult. Amphotericin B / administration & dosage. Amphotericin B / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Drug Combinations. Drug Therapy, Combination. Echinocandins / administration & dosage. Echinocandins / therapeutic use. Female. Hematopoietic Stem Cell Transplantation. Humans. Itraconazole / administration & dosage. Itraconazole / therapeutic use. Male. Middle Aged. Neutropenia / chemically induced. Neutropenia / complications. Phosphatidylcholines / administration & dosage. Phosphatidylcholines / therapeutic use. Phosphatidylglycerols / administration & dosage. Phosphatidylglycerols / therapeutic use. Pyrimidines / administration & dosage. Pyrimidines / therapeutic use. Treatment Outcome. Voriconazole

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  • (PMID = 18094720.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Drug Combinations; 0 / Echinocandins; 0 / Phosphatidylcholines; 0 / Phosphatidylglycerols; 0 / Pyrimidines; 0 / Triazoles; 0 / liposomal amphotericin B; 304NUG5GF4 / Itraconazole; 6TK1G07BHZ / posaconazole; 7XU7A7DROE / Amphotericin B; F0XDI6ZL63 / caspofungin; JFU09I87TR / Voriconazole
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64. Meyer C, Heiss C, Drexhage C, Kehmeier ES, Balzer J, Mühlfeld A, Merx MW, Lauer T, Kühl H, Floege J, Kelm M, Rassaf T: Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function. J Am Coll Cardiol; 2010 Feb 2;55(5):454-9
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  • OBJECTIVES: This study sought to characterize the impact of hemodialysis (HD)-induced release of hemoglobin on the bioavailability of nitric oxide (NO) and endothelial function.
  • BACKGROUND: Patients on chronic HD suffer from endothelial dysfunction and a massively increased risk for cardiovascular events.
  • METHODS: In 14 HD patients (56+/-15 years of age), endothelial function was determined by measuring flow-mediated dilation (FMD) of the brachial artery using high-resolution ultrasound before and after treatment.
  • RESULTS: HD impaired FMD (3.5+/-2.6% to 1.7+/-1.4%, p=0.04) without affecting brachial artery diameter (4.7+/-0.6 mm vs. 4.4+/-0.9 mm, p=0.27).
  • The amount of decompartmentalized hemoglobin after HD correlated inversely with the change in FMD (r=-0.65, p=0.041).
  • CONCLUSIONS: Our data support a role of HD-induced release of hemoglobin in the pathogenesis of endothelial dysfunction in patients with end-stage renal disease.
  • [MeSH-minor] Adult. Aged. Brachial Artery / physiopathology. Female. Hemolysis. Humans. Male. Middle Aged. Vasodilation

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  • [Copyright] Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Am Coll Cardiol. 2010 Feb 2;55(5):460-2 [20117460.001]
  • (PMID = 20117459.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00764192
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 31C4KY9ESH / Nitric Oxide
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65. Gottsch ML, Clifton DK, Steiner RA: Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis. Mol Cell Endocrinol; 2006 Jul 25;254-255:91-6
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  • Centrally administered kisspeptins stimulate GnRH and gonadotropin secretion in prepubertal and adult animals.

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  • (PMID = 16762492.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK61517; United States / NICHD NIH HHS / HD / R01 HD27142; United States / NICHD NIH HHS / HD / U54 HD 12629
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 0 / KISS1 protein, human; 0 / KISS1R protein, human; 0 / Kisspeptins; 0 / RNA, Messenger; 0 / Receptors, G-Protein-Coupled; 0 / Tumor Suppressor Proteins; 33515-09-2 / Gonadotropin-Releasing Hormone
  • [Number-of-references] 62
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66. Ramirez R, Carracedo J, Merino A, Nogueras S, Alvarez-Lara MA, Rodríguez M, Martin-Malo A, Tetta C, Aljama P: Microinflammation induces endothelial damage in hemodialysis patients: the role of convective transport. Kidney Int; 2007 Jul;72(1):108-13
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  • We compared on-line hemofiltration to high-flux hemodialysis (HF-HD) in patients in a sequential manner.
  • At baseline, 15 stable patients on HF-HD as compared with five control subjects showed significant increases in CD14+CD16+ cells, endothelial microparticles, and endothelial progenitor cells (EPCs).
  • After returning to HF-HD for 4 months, all measured parameters returned to their respective baseline values.
  • [MeSH-minor] Adult. Aged. Annexin A5 / metabolism. Antigens, CD14 / blood. Antigens, CD31 / metabolism. Cardiovascular Diseases / etiology. Cardiovascular Diseases / pathology. Cardiovascular Diseases / physiopathology. Cells, Cultured. Chronic Disease. Female. Humans. Male. Middle Aged. Receptors, IgG / blood. Stem Cells / metabolism. Stem Cells / pathology

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  • (PMID = 17429343.001).
  • [ISSN] 0085-2538
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Antigens, CD14; 0 / Antigens, CD31; 0 / Receptors, IgG
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67. Weerasinghe DP, Wolfenden HD, Yusuf F: Coronary artery bypass graft surgery trends in New South Wales, Australia. Public Health; 2008 Feb;122(2):151-60
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  • The predictors of extended post-surgery length of stay were age, insulin-dependent diabetes, acute and chronic renal failure, congestive heart failure, pulmonary disease and having more than three vein grafts.
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Australia. Comorbidity. Female. Humans. Length of Stay / statistics & numerical data. Male. Middle Aged. Postoperative Complications / epidemiology. Sex Distribution

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  • (PMID = 17662316.001).
  • [ISSN] 0033-3506
  • [Journal-full-title] Public health
  • [ISO-abbreviation] Public Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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68. Birnboim-Blau G, Levin L, Sgan-Cohen HD: Dental status among native and immigrant young Israeli adults. Refuat Hapeh Vehashinayim (1993); 2006 Jan;23(1):6-11, 67
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  • [Title] Dental status among native and immigrant young Israeli adults.
  • The goals of this study included comparing caries prevalence levels and different modes of treatment and dental health behavior, among immigrants from the former USSR and Israeli born young adults.
  • METHODS: 581 young adults (average age 18 years) answered a questionnaire and were clinically examined.
  • [MeSH-minor] Adolescent. Adult. Attitude to Health. DMF Index. Dental Care / psychology. Dental Care / utilization. Educational Status. Employment. Family Characteristics. Humans. Israel / epidemiology. Prevalence. Smoking / epidemiology. Surveys and Questionnaires. USSR / ethnology

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  • (PMID = 16599327.001).
  • [ISSN] 0792-9935
  • [Journal-full-title] Refuʼat ha-peh ṿeha-shinayim (1993)
  • [ISO-abbreviation] Refuat Hapeh Vehashinayim (1993)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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69. Tran PV, Fretham SJ, Carlson ES, Georgieff MK: Long-term reduction of hippocampal brain-derived neurotrophic factor activity after fetal-neonatal iron deficiency in adult rats. Pediatr Res; 2009 May;65(5):493-8
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  • [Title] Long-term reduction of hippocampal brain-derived neurotrophic factor activity after fetal-neonatal iron deficiency in adult rats.

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  • (PMID = 19190544.001).
  • [ISSN] 1530-0447
  • [Journal-full-title] Pediatric research
  • [ISO-abbreviation] Pediatr. Res.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD029421-14; United States / NICHD NIH HHS / HD / R01 HD29421; United States / NIMH NIH HHS / MH / MH073129-05; United States / NINDS NIH HHS / NS / F31 NS047876; United States / NIMH NIH HHS / MH / T32 MH073129-05; United States / NICHD NIH HHS / HD / R01 HD029421-14; United States / NICHD NIH HHS / HD / R29 HD029421; United States / NIMH NIH HHS / MH / T32 MH073129; United States / NIMH NIH HHS / MH / T32MH073129; United States / NICHD NIH HHS / HD / R01 HD029421
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; 0 / Early Growth Response Protein 1; 0 / Early Growth Response Protein 2; 0 / Egr1 protein, rat; 0 / Egr2 protein, rat; 0 / Hif1a protein, rat; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Iron, Dietary; 0 / Myelin Basic Protein; 0 / Proto-Oncogene Proteins c-fos; 0 / RNA, Messenger; 67763-97-7 / Insulin-Like Growth Factor II; E1UOL152H7 / Iron; EC 1.1.1.- / Hydroxymethylglutaryl CoA Reductases; EC 2.7.10.1 / Receptor, trkB; EC 3.1.3.- / Mitogen-Activated Protein Kinase Phosphatases; EC 3.1.3.48 / Dual-Specificity Phosphatases; EC 3.1.3.48 / Dusp4 protein, rat
  • [Other-IDs] NLM/ NIHMS110299; NLM/ PMC2715440
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71. Bradbury BD, Fissell RB, Albert JM, Anthony MS, Critchlow CW, Pisoni RL, Port FK, Gillespie BW: Predictors of early mortality among incident US hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clin J Am Soc Nephrol; 2007 Jan;2(1):89-99
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  • Mortality risk among hemodialysis (HD) patients may be highest soon after initiation of HD.
  • A period of elevated mortality risk was identified among US incident HD patients, and which patient characteristics predict death during this period and throughout the first year was examined using data from the Dialysis Outcomes and Practice Patterns Study (DOPPS; 1996 through 2004).
  • Cox regression was used to estimate adjusted hazard ratios (HR) measuring associations between patient characteristics and mortality and to examine whether these associations changed during the first year of HD.
  • Most covariates were found to have consistent effects during the first year of HD: Older age, catheter vascular access, albumin <3.5, phosphorus <3.5, cancer, and congestive heart failure all were associated with elevated mortality.
  • Mortality risk was highest in the first 120 d after HD initiation.
  • Inadequate predialysis nephrology care was strongly associated with mortality during this period, highlighting the potential benefits of contact with a nephrologist at least 1 mo before HD initiation.
  • [MeSH-minor] Adolescent. Adult. Aged. Cause of Death. Female. Humans. Incidence. Male. Middle Aged. Practice Guidelines as Topic. Predictive Value of Tests. Risk Factors. Treatment Outcome. United States / epidemiology

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  • [CommentIn] Clin J Am Soc Nephrol. 2007 Jan;2(1):143-5 [17699398.001]
  • (PMID = 17699392.001).
  • [ISSN] 1555-905X
  • [Journal-full-title] Clinical journal of the American Society of Nephrology : CJASN
  • [ISO-abbreviation] Clin J Am Soc Nephrol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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72. Jaquiéry E, Jilek S, Schluep M, Le Goff G, Garcia M, Pantaleo G, Du Pasquier RA: Cytokine mRNA profile of Epstein-Barr virus-stimulated highly differentiated T cells in multiple sclerosis: a pilot study. J Neuroimmunol; 2010 Aug 25;225(1-2):167-70
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  • In this exploratory pilot study, we assessed IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-17, IFN-gamma, TGF-beta1 and FOXP3 mRNA expression in EBV-stimulated highly differentiated T cells (T(HD)) of MS patients and healthy controls (HC).
  • We found increased levels of IFN-gamma and IL-4 mRNA in CD8+ T(HD) cells of MS patients.
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Enzyme-Linked Immunosorbent Assay / methods. Female. Flow Cytometry. Herpesvirus 4, Human. Humans. Male. Middle Aged. Pilot Projects. Statistics, Nonparametric

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20471696.001).
  • [ISSN] 1872-8421
  • [Journal-full-title] Journal of neuroimmunology
  • [ISO-abbreviation] J. Neuroimmunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Cytokines; 0 / RNA, Messenger
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73. Allegaert K, Verbesselt R, Naulaers G, van den Anker JN, Rayyan M, Debeer A, de Hoon J: Developmental pharmacology: neonates are not just small adults... Acta Clin Belg; 2008 Jan-Feb;63(1):16-24
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  • [Title] Developmental pharmacology: neonates are not just small adults...
  • Until adult metabolic activity has been reached, ontogeny, i.e. isoenzyme-specific maturation and maturation of renal clearance also contributes to drug metabolism, making isoenzyme-specific documentation of maturation necessary.
  • Both hepatic metabolism and renal clearance display maturation in early life although other covariables (e.g. polymorphisms, co-administration of drugs, first pass metabolism, disease characteristics) further contribute to the interindividual variability in drug disposition.

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  • (PMID = 18386761.001).
  • [ISSN] 1784-3286
  • [Journal-full-title] Acta clinica Belgica
  • [ISO-abbreviation] Acta Clin Belg
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / 5U10HD045993-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Belgium
  • [Number-of-references] 46
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74. Rakison DH: Does women's greater fear of snakes and spiders originate in infancy? Evol Hum Behav; 2009 Nov 1;30(6):439-444
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  • Previous studies with adult humans and non-human animals revealed more rapid fear learning for spiders and snakes than for mushrooms and flowers.

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  • (PMID = 20160910.001).
  • [ISSN] 1090-5138
  • [Journal-full-title] Evolution and human behavior : official journal of the Human Behavior and Evolution Society
  • [ISO-abbreviation] Evol. Hum. Behav.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD049511-01; United States / NICHD NIH HHS / HD / HD049511-02; United States / NICHD NIH HHS / HD / R03 HD049511
  • [Publication-type] JOURNAL ARTICLE
  • [Publication-country] United States
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75. Huang ES, Karter AJ, Danielson KK, Warton EM, Ahmed AT: The association between the number of prescription medications and incident falls in a multi-ethnic population of adult type-2 diabetes patients: the diabetes and aging study. J Gen Intern Med; 2010 Feb;25(2):141-6
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  • [Title] The association between the number of prescription medications and incident falls in a multi-ethnic population of adult type-2 diabetes patients: the diabetes and aging study.
  • It is unclear whether this polypharmacy-fall relationship differs for adults with diabetes.
  • CONCLUSIONS: The prescription of four or more medications was associated with an increased risk of falls among adult diabetes patients, while no specific glucose-lowering agent was linked to increased risk.

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  • (PMID = 19967465.001).
  • [ISSN] 1525-1497
  • [Journal-full-title] Journal of general internal medicine
  • [ISO-abbreviation] J Gen Intern Med
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK081796-01A1; United States / NICHD NIH HHS / HD / R01 HD046113; United States / NIDDK NIH HHS / DK / R01 DK065664; United States / NIA NIH HHS / AG / K23 AG021963; None / None / / R01 DK081796-01A1; United States / NIDDK NIH HHS / DK / R01 DK081796; United States / NIDDK NIH HHS / DK / P60 DK020595
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2837501
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76. Al-Hwiesh AK, Abdul-Rahman IS: Successful prevention of tunneled, central catheter infection by antibiotic lock therapy using vancomycin and gentamycin. Saudi J Kidney Dis Transpl; 2007 Jun;18(2):239-47
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  • Tunneled, cuffed central vein catheters (TCC) are widely used for delivering hemodialysis (HD).
  • Among the complications associated with central vein catheters in HD patients, infection is the principal cause of morbidity and mortality.
  • This prospective study was aimed at assessing the efficacy of antibiotic-lock therapy using vancomycin and gentamycin in preventing catheter-related blood stream bacterial infection in patients on HD.
  • A total of 63 HD patients with 81 TCC were enrolled at the time of catheter insertion.
  • Our study suggests that antibiotic-lock therapy using a combination of vancomycin and gentamycin is useful in preventing catheter-related blood stream infection in patients on HD.
  • [MeSH-minor] Adult. Drug Therapy, Combination. Female. Follow-Up Studies. Humans. Incidence. Kidney Failure, Chronic / therapy. Male. Middle Aged. Prospective Studies. Renal Dialysis / adverse effects. Renal Dialysis / instrumentation. Time Factors. Treatment Outcome

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  • (PMID = 17496402.001).
  • [ISSN] 1319-2442
  • [Journal-full-title] Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • [ISO-abbreviation] Saudi J Kidney Dis Transpl
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Gentamicins; 6Q205EH1VU / Vancomycin
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77. Tkacheva ON, Vertkin AL, Barabashkina AV, Vasil'eva AV, Razguliaeva NF: [Nebivolol effects on the cardiovascular system and the kidneys in pregnant and puerperal women with hypertension]. Ter Arkh; 2006;78(10):56-61
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  • MATERIAL AND METHODS: Monitoring of endothelial function, central and peripheral hemodynamics (HD), myocardial function, intrarenal circulation and microalbuminuria (MAU) was performed in 90 pregnant (67 hypertensive and 23 normotensive) and 18 puerperal women who were diagnosed to have hypertension in pregnancy.
  • RESULTS: Hypertensive gravidas had marked endothelial dysfunction (ED), impaired intrarenal HD, MAU, high total peripheral vascular resistance and left ventricular myocardial mass index (LVMMI).
  • The puerperas with hypertension had ED, MAU, frequently HD disorders and a trend to a LVMMI rise.
  • Nebivolol effectively reduced blood pressure, had a nephroprotective action, and improved HD and endothelial function.
  • [MeSH-minor] Adult. Albuminuria / epidemiology. Endothelium, Vascular / drug effects. Endothelium, Vascular / physiopathology. Female. Humans. Kidney / blood supply. Kidney / pathology. Myocardial Infarction / drug therapy. Myocardial Infarction / epidemiology. Myocardial Infarction / physiopathology. Nebivolol. Pregnancy. Pregnancy Outcome. Renal Insufficiency, Chronic / epidemiology. Renal Insufficiency, Chronic / pathology

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  • (PMID = 17180940.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Benzopyrans; 0 / Ethanolamines; 030Y90569U / Nebivolol
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78. Hanna N, Vasquez P, Pham P, Heck DE, Laskin JD, Laskin DL, Weinberger B: Mechanisms underlying reduced apoptosis in neonatal neutrophils. Pediatr Res; 2005 Jan;57(1):56-62
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  • The present studies show that membrane phosphatidylserine turnover and permeability, as well as DNA fragmentation, were reduced in neutrophils from neonates when compared with adults.
  • The activity of caspase 3 and expression of the proapoptotic proteins Bax, Bad, and Bak were also decreased in neonatal relative to adult neutrophils.
  • We found that expression of FasR was decreased in neonatal when compared with adult cells.
  • However, in both adult and neonatal cells, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase inhibitors blocked Fas-induced activity.
  • [MeSH-minor] Adult. Antigens, CD14 / biosynthesis. Carrier Proteins / metabolism. Caspase 3. Caspases / metabolism. Chemotaxis. DNA Fragmentation. Fas Ligand Protein. Fetal Blood / cytology. Flow Cytometry. Humans. Infant, Newborn. Membrane Glycoproteins / metabolism. Membrane Proteins / metabolism. Microscopy, Fluorescence. Monocytes / pathology. Permeability. Phagocytosis. Phosphatidylserines / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Signal Transduction. bcl-2 Homologous Antagonist-Killer Protein. bcl-2-Associated X Protein. bcl-Associated Death Protein

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  • (PMID = 15557111.001).
  • [ISSN] 0031-3998
  • [Journal-full-title] Pediatric research
  • [ISO-abbreviation] Pediatr. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA100994; United States / NIEHS NIH HHS / ES / ES04738; United States / NIEHS NIH HHS / ES / ES05022; United States / NIGMS NIH HHS / GM / GM34310; United States / NICHD NIH HHS / HD / HD42036
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD14; 0 / BAD protein, human; 0 / BAK1 protein, human; 0 / BAX protein, human; 0 / Carrier Proteins; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Phosphatidylserines; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2 Homologous Antagonist-Killer Protein; 0 / bcl-2-Associated X Protein; 0 / bcl-Associated Death Protein; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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79. Itoh K, Tanaka M, Matsushita K, Miyamura N, Nishida K, Araki E, Nonoguchi H, Tomita K: [Clinical courses of two male siblings on hemodialysis for Fabry disease ]. Nihon Jinzo Gakkai Shi; 2005;47(2):121-7
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  • [Title] [Clinical courses of two male siblings on hemodialysis for Fabry disease ].
  • Fabry disease is an X-linked recessive disease resulting from a deficiency of the lysosomal hydrolase alpha-galactosidase A.
  • Recently, it was reported that 0.5-1.2% of male chronic hemodialysis (HD) patients were diagnosed as having Fabry disease based on the measurement of alpha-galactosidase A activity.
  • Fabry disease is thought to be an important cause of end-stage renal disease.
  • There are a few reports of patients with Fabry disease on long-term HD.
  • Here we report two male siblings with classical type Fabry disease on HD.
  • Their mother had severe heart failure due to a heterozygous form of Fabry disease.
  • He started maintenance HD in 2000.
  • He started maintenance HD in 1993.
  • In conclusion, cardiovascular complications, cerebrovascular manifestations, painful ectopic carcifications, and chronic diarrheas in our patients were considered to be specific symptoms of Fabry disease.
  • Young HD patients with these symptoms will need to be examined for Fabry disease.
  • [MeSH-major] Fabry Disease / genetics. Fabry Disease / therapy. Renal Dialysis
  • [MeSH-minor] Adult. Chromosomes, Human, X / genetics. Genes, Recessive. Humans. Male. Siblings. alpha-Galactosidase / administration & dosage

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  • (PMID = 15859134.001).
  • [ISSN] 0385-2385
  • [Journal-full-title] Nihon Jinzo Gakkai shi
  • [ISO-abbreviation] Nihon Jinzo Gakkai Shi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.2.1.22 / alpha-Galactosidase
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80. Yashiro M, Kamata T, Segawa H, Murakami T, Kadoya Y, Muso E: How does higher ultrafiltration within the conventional clinical range impact the volume status of hemodialysis patients? Blood Purif; 2009;27(3):253-60
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  • METHODS: 60 hemodialysis (HD) patients were divided into three groups according to the ratio of total UF to post-dialysis body weight (TUF/PDW) (<3%, 3-5%, > or =5%).
  • ANP, the ratio of extracellular water to total body water and excess fluid mass (ExF/PDW) by bioimpedance spectroscopy, inferior vena cava diameter by ultrasound were measured at the end of HD.
  • The ratio of post-HD blood volume to pre-HD (BVpost/BVpre) and standardized filtration coefficients (Lpst) of the microvasculature in the vicinity of PDW were calculated.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Body Water. Electric Impedance. Extracellular Fluid. Extracellular Space. Humans. Middle Aged. Vena Cava, Inferior / ultrasonography. Water-Electrolyte Balance

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19218793.001).
  • [ISSN] 1421-9735
  • [Journal-full-title] Blood purification
  • [ISO-abbreviation] Blood Purif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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81. Kuo J, Hamid N, Bondar G, Prossnitz ER, Micevych P: Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. J Neurosci; 2010 Sep 29;30(39):12950-7
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  • In hypothalamic astrocytes obtained from adult female rats, estradiol rapidly increased free cytoplasmic calcium concentrations ([Ca(2+)](i)) that facilitate progesterone synthesis.

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  • (PMID = 20881113.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD042635-06A1; United States / NICHD NIH HHS / HD / HD042635-06A1; United States / NICHD NIH HHS / HD / HD042635-07; United States / NICHD NIH HHS / HD / HD00849-23; United States / NICHD NIH HHS / HD / R01 HD042635; United States / NICHD NIH HHS / HD / HD001281; United States / NICHD NIH HHS / HD / HD42635; United States / NICHD NIH HHS / HD / R01 HD042635-07; United States / NICHD NIH HHS / HD / K12 HD001281
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 4G7DS2Q64Y / Progesterone; 4TI98Z838E / Estradiol; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS240870; NLM/ PMC2957903
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82. Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC: Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol; 2009 Jun;296(6):F1484-93
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  • In both fetal and adult sheep kidney, PD competed for the majority of cortical NUC (> or =70%) and PM (> or =80%) sites while LOS competition predominated in medullary NUC (> or =75%) and PM (> or =70%).

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