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1. Nunes LF, Fiod NJ, Vasconcelos RA, Meohas W, Rezende JF: [Epithelioid sarcoma: clinical behavior, prognostic factors and survival]. Rev Col Bras Cir; 2010 Aug;37(4):251-5
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  • [Title] [Epithelioid sarcoma: clinical behavior, prognostic factors and survival].
  • [Transliterated title] Sarcoma epitelióide: aspectos clínicos, fatores prognósticos e sobrevida.
  • OBJECTIVE: To relate the clinical characteristics and evaluations of patients with epithelioid sarcomas.
  • METHODS: Careful analysis of 25 epithelioid sarcoma cases registered in Instituto Nacional do Cancer between june 1987 and july 2005.
  • CONCLUSION: Epithelioid sarcoma is a rare subset of soft tissue sarcoma with high rate of local recurrence, regional node and distant metastases.
  • Surgical treatment of epithelioid sarcoma consists of early wide local resection to negative microscopic margins.
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / mortality. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Prognosis. Survival Rate. Young Adult

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  • (PMID = 21085839.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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2. Ardeleanu C, Comănescu M, Comănescu V, Andrei F: Uncommon pattern in soft tissues epithelioid sarcoma. Rom J Morphol Embryol; 2005;46(3):229-33
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  • [Title] Uncommon pattern in soft tissues epithelioid sarcoma.
  • Epithelioid sarcoma (ES) is a rare tumor, but extremely versatile, simulating easily both clinically and morphologically multiple benign lesions as granulomas and malignant tumors as achromic melanomas or carcinomas.
  • AIM: To report some peculiar histological and immunophenotypic aspects in soft parts epithelioid sarcoma.
  • MATERIALS AND METHODS: We analyzed retrospectively three cases of epithelioid sarcomas with unusual clinico-morphological (large dimensions), histopathological (absence of necrosis) and immunohistochemical (IHC) patterns selected from 200 consecutive soft parts malignant tumors of "Victor Babeş" National Institute Bucharest files.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, CD34 / analysis. Child. Humans. Immunohistochemistry. Middle Aged. Retrospective Studies

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  • (PMID = 16444310.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34
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3. de Visscher SA, van Ginkel RJ, Wobbes T, Veth RP, Ten Heuvel SE, Suurmeijer AJ, Hoekstra HJ: Epithelioid sarcoma: Still an only surgically curable disease. Cancer; 2006 Aug 1;107(3):606-12
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  • [Title] Epithelioid sarcoma: Still an only surgically curable disease.
  • BACKGROUND: Epithelioid sarcoma is a rare soft tissue sarcoma with a known high propensity for locoregional recurrence and distant metastases.
  • The clinical behavior and prognostic factors that influence the survival of patients with epithelioid sarcoma were studied.
  • METHODS: Twenty-three patients, including 16 men (70%) and 7 women (30%), who were treated for epithelioid sarcoma between 1979-2003 at the University Medical Center Groningen and Radboud University Nijmegen Medical Center, were reviewed retrospectively.
  • CONCLUSIONS: The prognosis for patients with epithelioid sarcoma is poor, because a substantial number of patients present with extensive disease, lymph node metastases, and/or distant metastases.
  • [MeSH-major] Epithelioid Cells / pathology. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Infant. Male. Middle Aged. Neoplasm Staging. Netherlands. Prognosis. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright 2006 American Cancer Society.
  • (PMID = 16804932.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Jawad MU, Extein J, Min ES, Scully SP: Prognostic factors for survival in patients with epithelioid sarcoma: 441 cases from the SEER database. Clin Orthop Relat Res; 2009 Nov;467(11):2939-48
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  • [Title] Prognostic factors for survival in patients with epithelioid sarcoma: 441 cases from the SEER database.
  • Current stratification of prognosis in patients with epithelioid sarcoma (ES) is based largely on data reported by individual centers with a limited number of patients.
  • Disease-specific survival declined until 100 months after diagnosis after which survival was unrelated to epithelioid sarcoma.
  • [MeSH-major] Bone Neoplasms / mortality. Bone Neoplasms / therapy. Sarcoma / mortality. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Databases, Factual. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness / pathology. Neoplasm Staging. Orthopedic Procedures / methods. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. SEER Program. Sex Factors. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 19224301.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2758965
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5. Armah HB, Parwani AV: Epithelioid sarcoma. Arch Pathol Lab Med; 2009 May;133(5):814-9
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  • [Title] Epithelioid sarcoma.
  • Epithelioid sarcomas are rare, mesenchymal tumors of unknown histogenesis and display multidirectional differentiation, which is predominantly epithelial.
  • They have no normal cellular counterpart and differ from both synovial sarcoma and carcinoma.
  • They account for less than 1% of all soft tissue sarcomas and are usually slow growing, with peak incidence in young adult men and occur predominantly in extremities.
  • Clinically, they have a high recurrence rate, and up to 50% of epithelioid sarcomas metastasize.
  • [MeSH-major] Sarcoma / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 19415960.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 30
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6. Pai KK, Pai SB, Sripathi H, Pranab, Rao P: Epithelioid sarcoma: a diagnostic challenge. Indian J Dermatol Venereol Leprol; 2006 Nov-Dec;72(6):446-8
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  • [Title] Epithelioid sarcoma: a diagnostic challenge.
  • Epithelioid sarcoma is an uncommon slow-growing soft tissue malignancy, associated with a high incidence of local recurrence and metastasis.
  • We report a 26-year-old male with epithelioid sarcoma on the right palm with a long history of over seven years, which was initially misdiagnosed as cutaneous tuberculosis and epithelioid hemangioendothelioma, as a result of which the treatment was delayed.
  • [MeSH-major] Hand. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Dermis / pathology. Diagnosis, Differential. Epidermis / pathology. Hemangioendothelioma, Epithelioid / pathology. Humans. Male

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  • (PMID = 17179622.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 8
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7. Sakamoto A, Jono O, Hirahashi M, Oya M, Iwamoto Y, Arai K: Epithelioid sarcoma with muscle metastasis detected by positron emission tomography. World J Surg Oncol; 2008;6:84
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  • [Title] Epithelioid sarcoma with muscle metastasis detected by positron emission tomography.
  • BACKGROUND: Epithelioid sarcoma is an uncommon high-grade sarcoma, mostly involving the extremities.
  • Diagnosis of epithelioid sarcoma was made by open biopsy, and amputation at the upper arm was then undertaken.
  • CONCLUSION: Increased uptake on FDG-PET might be representative of epithelioid sarcoma, and for this reason FDG-PET may be useful for detecting metastasis.
  • Muscle metastasis is not well documented in epithelioid sarcoma.
  • [MeSH-major] Fluorodeoxyglucose F18. Muscle Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Sarcoma / radionuclide imaging. Soft Tissue Neoplasms / radiography
  • [MeSH-minor] Adult. Biopsy. Humans. Magnetic Resonance Imaging. Male

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  • [Cites] J Bone Joint Surg Am. 1988 Jul;70(6):862-70 [3392084.001]
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  • (PMID = 18706085.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2527488
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8. Miyake M, Tanaka N, Matsushita C, Tanaka M, Tanaka M, Fujimoto K, Hirao Y, Konishi N: [Case of proximal-type epithelioid sarcoma of the perineum]. Nihon Hinyokika Gakkai Zasshi; 2006 Mar;97(3):602-6
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  • [Title] [Case of proximal-type epithelioid sarcoma of the perineum].
  • The pathological examination with immunohistochemistry revealed that the tumor was proximal-type epithelioid sarcoma.
  • Epithelioid sarcoma originating from the thigh or trunk is classified into the proximal-type, which shows significantly poorer prognosis than the distal-type that develops in the distal extremities.
  • The proximal-type epithelioid sarcoma of the perineum is rare and, to our knowledge, the present report is the fourth case in the Japanese literatures.
  • [MeSH-major] Perineum. Sarcoma / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Fatal Outcome. Humans. Male. Middle Aged. Treatment Failure

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  • (PMID = 16613163.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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9. Fisher C: Epithelioid sarcoma of Enzinger. Adv Anat Pathol; 2006 May;13(3):114-21
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  • [Title] Epithelioid sarcoma of Enzinger.
  • Epithelioid sarcoma was named in 1970 in a classic paper by Enzinger, who expanded the observations in a larger series in 1985.
  • He defined a sarcoma with a peak incidence in young adult males and a predilection for extremities, involving subcutis or deeper tissue and extending along tendon sheaths or aponeuroses.
  • Epithelioid sarcomas regularly express vimentin, cytokeratins, and epithelial membrane antigen, and about half are positive for CD34, but a wide range of other antigens can be expressed.
  • The tumor has no normal cellular counterpart and differs from both synovial sarcoma and carcinoma.
  • There is a wide differential diagnosis from numerous benign and malignant conditions, including granuloma annulare, melanoma, and epithelioid vascular neoplasms.
  • Epithelioid sarcoma has a high recurrence rate, which can be reduced by adequate surgery, and up to 40% metastasize, to regional lymph nodes, to lung, and other locations including scalp.
  • Thirty-six years after Enzinger's original account, epithelioid sarcoma remains a clinically and pathologically distinct, indolent but aggressive sarcoma of indeterminate lineage.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epithelioid Cells / pathology. Female. History, 20th Century. Humans. Male

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  • (PMID = 16778474.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 58
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10. Monacelli G, Spagnoli AM, Rizzo MI, Pardi M, Cascioli I, Irace S: [Dupuytren's disease simulated by epithelioid sarcoma with atypical perineural invasion of the median nerve. Case report]. G Chir; 2008 Apr;29(4):149-51
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  • [Title] [Dupuytren's disease simulated by epithelioid sarcoma with atypical perineural invasion of the median nerve. Case report].
  • [Transliterated title] Malattia di Dupuytren simulata da un sarcoma epitelioide con atipica invasione perineurale del nervo mediano. Caso clinico.
  • Epithelioid sarcoma is an infrequent tumour, especially in upper limb, which nerve spread is not common.
  • When he presented himself at our attention, the patient underwent surgical biopsy and new histological examination was made with diagnosis of epithelioid sarcoma.
  • [MeSH-major] Dupuytren Contracture / diagnosis. Fingers. Median Neuropathy / etiology. Sarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fascia / surgery. Humans. Male. Treatment Outcome

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  • (PMID = 18419978.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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11. Wolf PS, Flum DR, Tanas MR, Rubin BP, Mann GN: Epithelioid sarcoma: the University of Washington experience. Am J Surg; 2008 Sep;196(3):407-12
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  • [Title] Epithelioid sarcoma: the University of Washington experience.
  • BACKGROUND: Epithelioid sarcoma is a rare sarcoma with a high local recurrence rate that frequently metastasizes to lymph nodes.
  • METHODS: Between 1990 and 2003, we treated 11 patients with epithelioid sarcoma.
  • CONCLUSIONS: Although surgery remains the primary treatment modality, multi-institutional trials are needed to develop more effective adjuvant therapy for patients with epithelioid sarcoma.
  • [MeSH-major] Sarcoma / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Washington

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  • (PMID = 18436180.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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12. Dainese E, Sessa F, Riva C, Placidi C, Capella C: ["Proximal type" epithelioid sarcoma of the vulva: differential diagnosis with other extrarenal rhabdoid tumors]. Pathologica; 2005 Jun;97(3):133-6
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  • [Title] ["Proximal type" epithelioid sarcoma of the vulva: differential diagnosis with other extrarenal rhabdoid tumors].
  • [Transliterated title] Sarcoma epitelioide di tipo prossimale della vulva: diagnosi differenziale con altri tumori rabdoidi extrarenali.
  • Proximal type epithelioid sarcoma is a rare neoplasia in which morphological findings are characterized by nodular proliferation of epithelioid cells with focal rhabdoid features.
  • We describe a case of vulvar proximal type epithelioid sarcoma in a 34 years old woman.
  • [MeSH-major] Diagnostic Errors. Sarcoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Epidermal Cyst / diagnosis. Female. Humans. Intermediate Filaments / pathology. Lymph Node Excision. Mucin-1 / analysis. Neoplasm Proteins / analysis. Reoperation. Rhabdoid Tumor / classification. Rhabdoid Tumor / diagnosis

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  • (PMID = 16259280.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Neoplasm Proteins
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13. Chao KC, Chen C, Hsieh SC, Fang CL, Lao WT, Chan WP: MRI of epithelioid sarcoma of the thigh. Clin Imaging; 2005 Jan-Feb;29(1):60-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of epithelioid sarcoma of the thigh.
  • A 31-year-old woman with epithelioid sarcoma of the thigh is presented.
  • Histologic findings were compatible with epithelioid sarcoma.
  • [MeSH-major] Magnetic Resonance Imaging. Sarcoma / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Thigh

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  • (PMID = 15859019.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Herr MJ, Harmsen WS, Amadio PC, Scully SP: Epithelioid sarcoma of the hand. Clin Orthop Relat Res; 2005 Feb;(431):193-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid sarcoma of the hand.
  • Twenty-eight patients were treated for a primary epithelioid sarcoma of the hand.
  • Twenty-seven patients (96%) had excisions before evaluation, including 11 (39%) with multiple prior excisions with varying diagnoses before epithelioid sarcoma, and all had surgical treatment after referral.
  • [MeSH-major] Hand. Sarcoma
  • [MeSH-minor] Adult. Amputation. Disease-Free Survival. Female. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local

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  • (PMID = 15685075.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Nishida T, Takahashi T, Nakajima K, Tsujinaka T, Hirota S: KIT and PDGFRA mutations of gastrointestinal stromal tumor. J Clin Oncol; 2009 May 20;27(15_suppl):10560

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Using RNA obtained from fresh samples of serial 209 pts with GIST (n=174), myogenic (21), neurogenic tumors (11), or GI sarcoma (3), KIT or PDGFRA cDNA was amplified by RT-PCR and fully sequenced.
  • WT are found in 3 juvenile GIST or 4 NF-1, and only 1 adult GIST showed WT.
  • PDGFRA mutations found in Ex 12 (4 pts) or Ex18 (13) are missense mutations and associated with gastric location, epithelioid histology (10/16), low mitotic activity and relatively indolent clinical features.
  • Mutations in KIT and PDGFRA are specific for GIST and WT GIST is extremely rare in adult pts except NF-1.

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  • (PMID = 27963809.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Sun L, Wu LY, Li XG, Bai P, Zhang HT: [Clinical characterization of vulvar epithelioid sarcoma]. Zhonghua Zhong Liu Za Zhi; 2010 Dec;32(12):935-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical characterization of vulvar epithelioid sarcoma].
  • OBJECTIVE: Vulvar epithelioid sarcoma is a rare, undifferentiated soft-tissue sarcoma, with a high rate of local relapse, regional nodal spread and distant metastases.
  • METHODS: We studied the clinicopathologic features of 20 cases of vulvar epithelioid sarcoma, of which 4 cases were admitted to our hospital from 1999 to 2009.
  • Radical local excision with adequate margin (at least 2 cm) and bilateral inguinofemoral lymphadenectomy is effective for the treatment of vulvar epithelioid sarcoma.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Keratins / metabolism. Lymph Node Excision. Lymphatic Metastasis. Middle Aged. Mucin-1 / metabolism. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Vimentin / metabolism. Vulva / surgery. Young Adult


17. Mentzel T: [Epithelioid sarcoma: morphologic variants and differential diagnosis]. Pathologe; 2010 Mar;31(2):135-41
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  • [Title] [Epithelioid sarcoma: morphologic variants and differential diagnosis].
  • Epithelioid sarcoma represents a rare sarcoma with a poor long-term prognosis that arises predominantly on the distal extremities of young adult patients, often mimicking a benign, non-neoplastic condition.
  • Histologically, epithelioid sarcoma is characterized by a multinodular growth with central necrosis, and the neoplasms are composed of relatively uniform epithelioid tumour cells showing a coexpression of vimentin, epithelial membrane antigen and pancytokeratin, and in about half of the cases of CD34.
  • Interestingly, most cases of epithelioid sarcoma show a loss of INI1, whereas the inactivation of the tumour suppressor gene SMARCB1/INI1 is only rarely caused by mutation.
  • The proximal variant of epithelioid sarcoma is composed of confluent sheets of enlarged epithelioid and rhabdoid tumour cells and represents the morphological progression of this entity.
  • The fibroma-like variant of epithelioid sarcoma as well as the angiomatoid and myxoid variants of epithelioid sarcoma are rare morphological variants and need to be considered in the differential diagnosis of other benign and malignant neoplasms.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19997734.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 21
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18. Guo Y, Tian GL: [Clinical analysis of 16 cases of epithelioid sarcoma]. Zhonghua Wai Ke Za Zhi; 2005 Aug 15;43(16):1066-8
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  • [Title] [Clinical analysis of 16 cases of epithelioid sarcoma].
  • METHODS: Review the clinical findings, pathologic features and results of the treatment of 16 cases of the epithelioid sarcoma in extremities, which were treated in our hospital from 1992 to 2004.
  • [MeSH-major] Sarcoma. Soft Tissue Neoplasms
  • [MeSH-minor] Adolescent. Adult. Extremities. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 16194334.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Xu LB, Yu SJ, Shao YF, Zhang HT, Zhao ZG: [Clinical analysis of 14 cases of epithelioid sarcoma]. Ai Zheng; 2007 Jul;26(7):782-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 14 cases of epithelioid sarcoma].
  • BACKGROUND & OBJECTIVE: Epithelioid sarcoma is a rare soft tissue sarcoma with a high propensity for aggressiveness, regional nodal spread, and distant metastases.
  • This study was to investigate the clinical features, diagnosis, treatment, and prognosis of epithelioid sarcoma.
  • METHODS: The clinical data of 14 patients with epithelioid sarcoma, admitted to our hospital from 1990 to 2005, were analyzed.
  • RESULTS: All diagnoses of epithelioid sarcoma were confirmed by pathology.
  • CONCLUSIONS: The prognosis of epithelioid sarcoma is poor because of a high propensity for local recurrence, node metastases, and distant metastases.
  • Extensive excision or radical excision combined local lymph node dissection is effective for epithelioid sarcoma.
  • [MeSH-major] Extremities / pathology. Sarcoma / pathology. Sarcoma / surgery. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Amputation. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 17626760.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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20. Lemos MM, Chaves P, Mendonça ME: Is preoperative cytologic diagnosis of epithelioid sarcoma possible? Diagn Cytopathol; 2008 Nov;36(11):780-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is preoperative cytologic diagnosis of epithelioid sarcoma possible?
  • Epithelioid sarcoma (ES) is a rare malignant neoplasm of the soft tissues with a predilection for distal extremities of young adults.
  • The preoperative fine-needle aspiration cytology (FNAC) differential diagnosis with necrotizing granuloma, carcinoma, melanoma, and other neoplasms with epithelioid morphology can be difficult and few cases have been described in the literature.
  • The cytologic features were compared with histologic features as well as with the FNA patterns of other neoplasms with epithelioid morphology that may be included in the differential diagnosis.
  • Cytologic smears showed tumor cells with an epithelioid to spindle cell morphology, dispersed and in loose clusters in close relation with a fibrillar hyaline material.
  • [MeSH-major] Preoperative Care. Sarcoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Neoplasm. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 18831016.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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21. Maksymiuk B, Smok-Ragankiewicz A, Snietura M, Lange D, Słomian G: Diagnostic problems concerning epithelioid sarcoma--case analysis. Pol J Pathol; 2005;56(3):139-44
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  • [Title] Diagnostic problems concerning epithelioid sarcoma--case analysis.
  • We discuss here five cases of epithelioid sarcoma (ES) with final diagnosis established after reexamination of initial findings.
  • Problems with differential diagnosis of these neoplasms arise since their microscopic picture may simulate several other pathological conditions such as non-neoplastic granulomatous reactions, squamous cell carcinomas and adenocarcinomas, melanomas and soft tissue sarcomas with epithelioid component.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Antigens, CD34 / metabolism. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Granuloma / pathology. Humans. Immunohistochemistry. Keratins / metabolism. Male. Melanoma / pathology. Middle Aged. Mucin-1 / metabolism. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 16334982.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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22. Kozawa E, Irisawa M, Heshiki A, Okagaki R, Shimizu Y: Magnetic resonance imaging findings of vulvar epithelioid sarcoma. Radiat Med; 2008 Jul;26(6):376-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging findings of vulvar epithelioid sarcoma.
  • We describe here a case of vulvar epithelioid sarcoma.
  • Epithelioid sarcoma is a malignant appendicular skin tumor that is rarely of vulvar origin.
  • To our knowledge, this is the first case of vulvar epithelioid sarcoma described in the MRI literature.
  • [MeSH-major] Magnetic Resonance Imaging. Sarcoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Young Adult


23. Kohashi K, Izumi T, Oda Y, Yamamoto H, Tamiya S, Taguchi T, Iwamoto Y, Hasegawa T, Tsuneyoshi M: Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. Hum Pathol; 2009 Mar;40(3):349-55
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  • [Title] Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor.
  • However, loss of SMARCB1/INI1 protein expression has recently been reported in other tumors as well, including a few cases of epithelioid sarcoma.
  • In addition, the histopathologic differences between proximal-type epithelioid sarcoma and malignant rhabdoid tumor have not been conclusively defined.
  • We analyzed SMARCB1/INI1 protein expression in 54 epithelioid sarcoma (proximal-type, 25; distal-type, 29) and examined alterations of the SMARCB1/INI1 gene in the cases lacking protein expression.
  • We found that 19 (76.0%) proximal-type epithelioid sarcoma and 27 (93.1%) distal-type epithelioid sarcoma showed loss of SMARCB1/INI1 protein expression.
  • Analysis of 39 cases with loss of protein expression revealed 4 cases (10.3%) with SMARCB1/INI1 gene alterations at the DNA level (homozygous deletion, 2; 1- or 2-bp deletion, 2) that could have induced the loss of gene products, and all 4 of these were proximal-type epithelioid sarcoma.
  • Epithelioid sarcoma was thus associated with a high frequency of loss of SMARCB1/INI1 protein expression similar to that in malignant rhabdoid tumor.
  • However, the frequency of SMARCB1/INI1 gene alteration at the DNA level in proximal-type epithelioid sarcoma was significantly lower than that in malignant rhabdoid tumor.
  • In addition, the prognosis of patients with malignant rhabdoid tumor is significantly worse than that of patients with proximal-type epithelioid sarcoma (P = .001).
  • Therefore, proximal-type epithelioid sarcoma and malignant rhabdoid tumor are suggested to be distinctive tumors with respect to the mechanism of the loss of SMARCB1/INI1 protein expression.
  • Analysis of alterations in the SMARCB1/INI1 gene may thus be a useful diagnostic tool to distinguish proximal-type epithelioid sarcoma from malignant rhabdoid tumor.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Mutation. Rhabdoid Tumor / genetics. Sarcoma / genetics. Soft Tissue Neoplasms / genetics. Transcription Factors / genetics
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. DNA Mutational Analysis. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Gene Dosage. Humans. Immunoenzyme Techniques. Kaplan-Meier Estimate. Male. Reverse Transcriptase Polymerase Chain Reaction. Survival Rate. Young Adult

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  • [CommentIn] Hum Pathol. 2009 Sep;40(9):1361-2; author reply 1362-4 [19683621.001]
  • (PMID = 18973917.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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24. Fadare O: Myxoid epithelioid sarcoma: clinicopathologic analysis of 2 cases. Int J Surg Pathol; 2009 Apr;17(2):147-52
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  • [Title] Myxoid epithelioid sarcoma: clinicopathologic analysis of 2 cases.
  • In the nearly 4 decades since its original delineation as a distinct clinicopathologic entity, several morphologic variations of epithelioid sarcoma have been described.
  • Furthermore, it has long been recognized that epithelioid sarcoma may display focal myxoid change.
  • Herein, the authors describe 2 examples of epithelioid sarcoma that displayed diffuse myxoid change.
  • Both cases were otherwise typical, both morphologically and immunophenotypically, of epithelioid sarcoma.
  • These cases further expand the morphologic spectrum of epithelioid sarcoma.
  • [MeSH-major] Muscle Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Combined Modality Therapy. Female. Humans. Male. Treatment Outcome. Young Adult

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  • (PMID = 18480401.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Chbani L, Guillou L, Terrier P, Decouvelaere AV, Grégoire F, Terrier-Lacombe MJ, Ranchère D, Robin YM, Collin F, Fréneaux P, Coindre JM: Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group. Am J Clin Pathol; 2009 Feb;131(2):222-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group.
  • Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Child. Chromosomal Proteins, Non-Histone / analysis. Combined Modality Therapy. DNA-Binding Proteins / analysis. Female. Humans. Male. Middle Aged. Mitotic Index. Survival Rate. Transcription Factors / analysis. Young Adult

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  • (PMID = 19141382.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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26. Goh SG, Chuah KL, Chew SH, Tan PH: Uterine epithelioid endometrial stromal sarcoma presenting as a "cervical polyp". Ann Diagn Pathol; 2005 Apr;9(2):101-5
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  • [Title] Uterine epithelioid endometrial stromal sarcoma presenting as a "cervical polyp".
  • Although appearance of conventional uterine endometrial stromal sarcoma is easily recognized on histology, it may uncommonly assume unusual appearances such as uterine tumor resembling ovarian sex-cord tumor, thereby hindering its diagnosis.
  • Recently, its manifestation as an epithelioid neoplasm was described.
  • In this report, we detail yet another instance where this tumor adopted an epithelioid morphology, presenting itself as a polyp extruding from the cervical os in a 41-year-old Chinese woman.
  • Both the polypectomy and subsequent hysterectomy specimens revealed a predominant proliferation of CD10-negative, caldesmon-negative, and CD117-positive epithelioid cells set within a stroma containing vascular proliferation resembling endometrial stromal tumor.
  • Areas of typical low-grade endometrial stromal sarcoma containing spindle cells that were focally positive for CD10 and negative for CD117 were present in close association with the epithelioid areas.
  • [MeSH-major] Endometrial Neoplasms / diagnosis. Polyps / diagnosis. Sarcoma, Endometrial Stromal / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neprilysin / metabolism. Proto-Oncogene Proteins c-kit / metabolism


27. El Bouanani A, Saidi H, Fikry T: [Rare localization of an aggressive epithelioid sarcoma in an adolescent]. Chir Main; 2010 Sep;29(4):266-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rare localization of an aggressive epithelioid sarcoma in an adolescent].
  • Epithelioid sarcoma is a rare soft-tissue sarcoma affecting mostly young adult males.
  • We report a case of epithelioid sarcoma of the left arm in a 16-year old adolescent of 8 months duration.
  • [MeSH-major] Arm / pathology. Neoplasm Recurrence, Local / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20724204.001).
  • [ISSN] 1769-6666
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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28. Steffensen TS, Gilbert-Barness E, Wagoner MJ, Bui MM, Browarsky IL: Human chorionic gonadotrophin producing epithelioid sarcoma metastatic to the placenta. Fetal Pediatr Pathol; 2008;27(6):282-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human chorionic gonadotrophin producing epithelioid sarcoma metastatic to the placenta.
  • Pregnancy complicated by sarcoma is a rare event, and metastasis to the placenta is exceptionally rare.
  • We report the first case of placental metastasis of an epithelioid sarcoma, an uncommon malignancy which most frequently affects young adults.
  • In addition to the typical histological features and immunophenotypic profile expected of epithelioid sarcoma, this tumor also expressed human chorionic gonadotrophin (HCG).
  • [MeSH-major] Chorionic Gonadotropin / metabolism. Placenta / pathology. Placenta Diseases / pathology. Pregnancy Complications, Neoplastic / pathology. Sarcoma / secondary
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Pregnancy. Young Adult

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  • (PMID = 19065326.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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29. Li L, Cen S, Huang F: [Clinical research on 11 cases of epithelioid sarcoma]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Dec;21(12):1315-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical research on 11 cases of epithelioid sarcoma].
  • OBJECTIVE: To investigate the clinical features, diagnosis, and treatment of patients with localized epithelioid sarcoma (ES).
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / surgery. Surgical Flaps. Upper Extremity / surgery
  • [MeSH-minor] Adolescent. Adult. Amputation. Bone Transplantation. Female. Hand / pathology. Hand / surgery. Humans. Lower Extremity / pathology. Lower Extremity / surgery. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local. Soft Tissue Injuries / surgery. Treatment Outcome. Young Adult

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  • (PMID = 18277674.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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30. Flucke U, Hulsebos TJ, van Krieken JH, Mentzel T: Myxoid epithelioid sarcoma: a diagnostic challenge. A report on six cases. Histopathology; 2010 Nov;57(5):753-9
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  • [Title] Myxoid epithelioid sarcoma: a diagnostic challenge. A report on six cases.
  • AIMS: Epithelioid sarcoma (ES) is a distinct sarcoma-type with a specific morphology and immunophenotype.
  • [MeSH-major] Myoepithelioma / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Female. Humans. Male. Middle Aged. Transcription Factors / genetics

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21083605.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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31. Koplin SA, Nielsen GP, Hornicek FJ, Rosenberg AE: Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases. Int J Surg Pathol; 2010 Jun;18(3):207-12
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  • [Title] Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases.
  • Epithelioid sarcoma is an uncommon malignancy that usually arises in the superficial soft tissues of the extremities.
  • Classically, epithelioid sarcoma grows as nodules of mild to moderately atypical epithelioid cells, frequently with central necrosis.
  • The presence of bone within epithelioid sarcoma raises a variety of lesions in the differential diagnosis, including reactive processes as well as benign and malignant neoplasms.This morphological variant of epithelioid sarcoma and its associated diagnostic pitfalls has received little attention in the literature.
  • The authors report herein 4 cases of epithelioid sarcoma with heterotopic bone and highlight the morphological characteristics of the bone and how such variants can be distinguished from other bone-forming lesions of the soft tissues.
  • [MeSH-major] Ossification, Heterotopic / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Child, Preschool. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Humans. Intermediate Filaments / ultrastructure. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20034988.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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32. Wang CN, An XJ, Shi QL, Xu Y, Zhou XJ, Li NY, Zhou HB, Ma HH: [Clinicopathological study of 5 cases of proximal-type epithelioid sarcoma]. Zhonghua Bing Li Xue Za Zhi; 2009 May;38(5):298-301
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  • [Title] [Clinicopathological study of 5 cases of proximal-type epithelioid sarcoma].
  • OBJECTIVE: To investigate the clinicopathological characteristics, diagnosis and differential diagnoses of proximal-type epithelioid sarcoma (PES).
  • The tumors consisted of relatively uniform epithelioid cells with round or oval nuclei and eosinophilic cytoplasm.
  • [MeSH-major] Pelvic Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Vimentin / metabolism. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mucin-1 / metabolism. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Young Adult. beta Catenin / metabolism


33. Kikuchi E, Kinoshita I, Yamazaki K, Itoh T, Shimizu T, Shimizu H, Nishimura M: Epithelioid sarcoma presenting as pulmonary cysts with cancer antigen 125 expression. Respirology; 2006 Nov;11(6):826-9
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  • [Title] Epithelioid sarcoma presenting as pulmonary cysts with cancer antigen 125 expression.
  • A final diagnosis of epithelioid sarcoma (ES) was made.
  • [MeSH-major] Bronchogenic Cyst / diagnosis. Bronchogenic Cyst / immunology. CA-125 Antigen / metabolism. Lung Neoplasms / diagnosis. Lung Neoplasms / immunology. Sarcoma / diagnosis. Sarcoma / immunology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / immunology. Adenocarcinoma / pathology. Adult. Biopsy. Diagnosis, Differential. Female. Humans. Skin / pathology

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  • (PMID = 17052316.001).
  • [ISSN] 1323-7799
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CA-125 Antigen
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34. Casanova M, Ferrari A, Collini P, Bisogno G, Alaggio R, Cecchetto G, Gronchi A, Meazza C, Garaventa A, Di Cataldo A, Carli M, Italian Soft Tissue Sarcoma Committee: Epithelioid sarcoma in children and adolescents: a report from the Italian Soft Tissue Sarcoma Committee. Cancer; 2006 Feb 1;106(3):708-17
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  • [Title] Epithelioid sarcoma in children and adolescents: a report from the Italian Soft Tissue Sarcoma Committee.
  • BACKGROUND: Epithelioid sarcoma (ES) is an uncommon malignant soft tissue tumor.
  • The current study concerns 30 patients age<18 years who were enrolled in the Italian Soft Tissue Sarcoma Committee protocols.
  • The current study data do not clearly confirm the strong tendency for the lymph node involvement described in adult ES patients.
  • [MeSH-major] Sarcoma / therapy. Soft Tissue Neoplasms / therapy

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 16353216.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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35. Zevallos-Giampietri EA, Barrionuevo C: Proximal-type epithelioid sarcoma: report of two cases in the perineum: differential diagnosis and review of soft tissue tumors with epithelioid and/or rhabdoid features. Appl Immunohistochem Mol Morphol; 2005 Sep;13(3):221-30
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  • [Title] Proximal-type epithelioid sarcoma: report of two cases in the perineum: differential diagnosis and review of soft tissue tumors with epithelioid and/or rhabdoid features.
  • The authors report two cases of perineal proximal-type epithelioid sarcoma in middle-aged men, age 51 and 43 years old.
  • Since proximal-type epithelioid sarcoma can be confused with a number of other soft tissue tumors with epithelioid and/or rhabdoid features, the authors emphasize the immunohistochemical differential diagnosis.

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  • (PMID = 16082246.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Brassesco MS, Valera ET, Castro-Gamero AM, Moreno DA, Silveira TP, Mori BM, Engel EE, Scrideli CA, Tone LG: Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report. Genet Mol Res; 2009;8(4):1211-7
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  • [Title] Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report.
  • Epithelioid sarcoma is a rare, aggressive soft tissue tumor of unknown histogenesis showing predominantly epithelioid cytomorphology.
  • We conducted a conventional and molecular cytogenetic study of a 27-year-old male with epithelioid sarcoma with angiomatoid features.
  • Cytogenetic analysis of epithelioid sarcoma metaphase spreads by GTG-banding revealed a diploid chromosome complement with structural and numerical aberrations.
  • Genetic evaluation of this rare condition may be useful in determining if epithelioid sarcoma is associated with a distinct genetic background.
  • [MeSH-major] Chromosome Aberrations. Sarcoma / genetics
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. In Situ Hybridization, Fluorescence. Male. Polymerase Chain Reaction


37. Eyden B, Wang G, Yao L: Epithelioid sarcoma: a case report with ultrastructural confirmation of myofibroblastic differentiation based on fibronexus junctions. Ultrastruct Pathol; 2009 Mar-Apr;33(2):61-6
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  • [Title] Epithelioid sarcoma: a case report with ultrastructural confirmation of myofibroblastic differentiation based on fibronexus junctions.
  • Epithelioid sarcoma is an uncommon but well-described malignancy, which is found predominantly in the soft tissues of the young and middle-aged, and which pursues an indolent to aggressive course.
  • Myofibroblastic differentiation has been recorded in epithelioid sarcoma for some time, the evidence being based mainly on the presence of smooth-muscle-type myofilaments and, more recently, on alpha-smooth-muscle actin and muscle-specific actin immunostaining.
  • The authors describe a conventional epithelioid sarcoma showing myofibroblastic differentiation based on the presence of fibronectin fibrils and fibronexus junctions.
  • Histologically, the tumors had the typical features of epithelioid sarcoma: by immunohistochemistry, cytokeratin, epithelial membrane antigen, and vimentin were positive.
  • This is the first epithelioid sarcoma of conventional histological type to show myofibroblastic differentiation on the basis of the more stringent criterion of the fibronexus.
  • [MeSH-major] Cell Transformation, Neoplastic / ultrastructure. Fibroblasts / ultrastructure. Intercellular Junctions / ultrastructure. Muscle Fibers, Skeletal / ultrastructure. Sarcoma / ultrastructure. Soft Tissue Neoplasms / ultrastructure
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasm / ultrastructure. Fibronectins / ultrastructure. Fingers / pathology. Fingers / surgery. Humans. Male. Microscopy, Electron, Transmission / methods. Neoplasm Recurrence, Local

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  • (PMID = 19274582.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fibronectins
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38. Barnoud R, Collardeau-Frachon S, de la Roche E, Vasiljevic A, Thomson V, Ranchère D, Devouassoux G, Devouassoux-Shisheboran M: [Lung metastases of epithelioid sarcoma revealed by bilateral spontaneous pneumothorax: a pathological diagnosis]. Ann Pathol; 2010 Apr;30(2):139-42
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  • [Title] [Lung metastases of epithelioid sarcoma revealed by bilateral spontaneous pneumothorax: a pathological diagnosis].
  • Spontaneous pneumothorax may be one of the presenting manifestation of metastatic epithelioid sarcoma even if imaging does not show evident metastatic nodules.
  • We report the case of a 24-year-old man presenting a bilateral spontaneous pneumothorax in association with an epithelioid sarcoma developed in the right foot.
  • Histopathological examination of the pulmonary biopsies revealed rare millimetric nodules, composed of very atypical epithelioid cells, growing along alveolar walls reminiscent of a bronchiolo-alveolar carcinoma.
  • All these constatations allowed a diagnosis of pulmonary metastases of the epithelioid sarcoma.
  • [MeSH-major] Foot Diseases / pathology. Lung Neoplasms / secondary. Pneumothorax / etiology. Sarcoma / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Doxorubicin / administration & dosage. Drainage. Fatal Outcome. Humans. Ifosfamide / administration & dosage. Male. Neoplasm Proteins / analysis. Pleurodesis. Thoracoscopy. Thoracotomy. Young Adult


39. Ikeda K, Tate G, Suzuki T, Mitsuya T: Fine needle aspiration cytology of primary proximal-type epithelioid sarcoma of the perineum: a case report. Acta Cytol; 2005 May-Jun;49(3):314-8
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  • [Title] Fine needle aspiration cytology of primary proximal-type epithelioid sarcoma of the perineum: a case report.
  • BACKGROUND: Epithelioid sarcoma is a malignant soft tissue tumor of unknown histogenesis.
  • We describe the cytologic findings in a case of primary proximal-type epithelioid sarcoma of the perineum and results of an immunofluorescence analysis of rhabdoid cells from this tumor.
  • To the best of our knowledge, the 3-color immunofluorescence features of proximal-type epithelioid sarcoma have never before been reported.
  • After excision of the tumor, histopathologic examination of the resected specimen suggested a diagnosis of proximal-type epithelioid sarcoma.
  • The cytoplasmic staining pattern differed between rhabdoid and epithelioid sarcoma cells.
  • CONCLUSION: Immunofluorescent staining of rhabdoid cells from a primary perineal proximal-type epithelioid sarcoma revealed an uneven distribution of cytokeratin in intracytoplasmic inclusions, with the highest concentration at the periphery of the inclusions.
  • [MeSH-major] Perineum. Sarcoma / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Immunohistochemistry. Male

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  • (PMID = 15966295.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Coulibaly B, Tasei AM, Payan-Defais MJ, Bouvier C, Trousse D, Doddoli C, Figarella-Branger D: [Pulmonary epithelioid haemangioendothelioma: two different clinical courses]. Rev Mal Respir; 2008 Sep;25(7):867-70
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  • [Title] [Pulmonary epithelioid haemangioendothelioma: two different clinical courses].
  • In both cases, chest radiography and thoracic CT scans showed multiple, bilateral pulmonary nodules, bronchial endoscopy was normal and surgical biopsy revealed epithelioid haemangioendothelioma.
  • Epithelioid haemangioendothelioma is a vascular tumour usually affecting women less than 40 years of age.
  • Epithelioid haemangioendothelioma is considered a sarcoma without precise histological prognostic criteria.
  • [MeSH-major] Hemangioendothelioma, Epithelioid. Lung Neoplasms
  • [MeSH-minor] Biopsy. Female. Follow-Up Studies. Humans. Lung / pathology. Male. Middle Aged. Radiography, Thoracic. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 18946414.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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41. Koga K, Nabeshima K, Aoki M, Kawakami T, Hamasaki M, Toole BP, Nakayama J, Iwasaki H: Emmprin in epithelioid sarcoma: expression in tumor cell membrane and stimulation of MMP-2 production in tumor-associated fibroblasts. Int J Cancer; 2007 Feb 15;120(4):761-8
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  • [Title] Emmprin in epithelioid sarcoma: expression in tumor cell membrane and stimulation of MMP-2 production in tumor-associated fibroblasts.
  • This study investigated the expression and role of emmprin in epithelioid sarcoma (ES).
  • [MeSH-major] Antigens, CD147 / metabolism. Cell Membrane / metabolism. Epithelioid Cells / metabolism. Fibroblasts / metabolism. Matrix Metalloproteinase 2 / metabolism. Sarcoma / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Coculture Techniques. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Tumor Cells, Cultured

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  • (PMID = 17131322.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 136894-56-9 / Antigens, CD147; EC 3.4.24.24 / Matrix Metalloproteinase 2
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42. Baratti D, Pennacchioli E, Casali PG, Bertulli R, Lozza L, Olmi P, Collini P, Radaelli S, Fiore M, Gronchi A: Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol; 2007 Dec;14(12):3542-51
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  • [Title] Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution.
  • BACKGROUND: Epithelioid sarcoma (ES) is a rare subtype of soft-tissue sarcoma of unknown histogenesis.
  • [MeSH-major] Epithelioid Cells / pathology. Sarcoma / mortality. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17909905.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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43. Folk GS, Williams SB, Foss RB, Fanburg-Smith JC: Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases. Head Neck Pathol; 2007 Sep;1(1):13-20
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  • [Title] Oral and maxillofacial sclerosing epithelioid fibrosarcoma: report of five cases.
  • Sclerosing epithelioid fibrosarcoma (SEF) has distinctive morphology and occurs mainly in deep soft tissue of adult extremities.
  • Inclusion required OMFR location, an abundantly sclerotic sarcoma with epithelioid features, and lack of other phenotype by immunohistochemistry.
  • The spindled to primarily epithelioid tumor cells formed moderately cellular sheets and cords of irregularly contoured medium to large, round to oval, occasionally overlapping nuclei, indistinct nucleoli, wispy eosinophilic (retracting) cytoplasm, and distinctive cytoplasmic borders, embedded in osteoid-like stroma.
  • The collagen, focal spindle cell features, HPC-like vasculature, and weak focal CD34 reactivity in one case might have raised a possible relationship between OMFRSEF and low grade malignant solitary fibrous tumor, but the intraosseous propensity, epithelioid features and relative lack of CD34 make this a distinctive entity.
  • [MeSH-minor] Adult. Apoptosis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Leiomyoma / diagnosis. Male. Middle Aged. Sclerosis. Solitary Fibrous Tumors / diagnosis. Young Adult

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  • [ErratumIn] Head Neck Pathol. 2013 Mar;7(1):103
  • (PMID = 20614275.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807507
  • [Keywords] NOTNLM ; Maxillofacial / Oral / Sarcoma / Sclerosing epithelioid fibrosarcoma
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44. Cascio MJ, O'Donnell RJ, Horvai AE: Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare. Mod Pathol; 2010 Apr;23(4):574-80
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  • [Title] Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare.
  • Epithelioid sarcoma is a rare, malignant, soft tissue neoplasm that can be classified into proximal, distal and fibroma-like subtypes.
  • Regardless of subtype, epithelioid sarcoma often shows morphologic and immunophenotypic evidence of epithelial differentiation.
  • EGFR expression has been reported in some sarcoma types, but expression, amplification and mutations have not been studied in epithelioid sarcoma.
  • We evaluated 15 cases of epithelioid sarcoma from 14 patients for EGFR expression using immunohistochemistry, EGFR copy number aberration using fluorescence in situ hybridization and screened for mutations in the tyrosine kinase domain of the EGFR gene using direct sequencing.
  • In all, 14 of the 15 epithelioid sarcomas (93%) showed expression of EGFR by immunohistochemistry.
  • These results imply that although EGFR is expressed in most epithelioid sarcomas regardless of subtype, gene amplification and activating mutations in the tyrosine kinase domain appear to be rare or absent.
  • Thus, the benefit of targeted therapy against EGFR in patients with epithelioid sarcoma remains to be determined.
  • [MeSH-major] Receptor, Epidermal Growth Factor / genetics. Sarcoma / genetics. Sarcoma / metabolism. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. DNA Mutational Analysis. Female. Gene Amplification. Gene Dosage. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20118913.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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45. Hoshino M, Kawashima H, Ogose A, Kudo N, Ariizumi T, Hotta T, Umezu H, Hatano H, Morita T, Nishio J, Iwasaki H, Endo N: Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcoma. J Cancer Res Clin Oncol; 2010 Mar;136(3):457-64
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  • [Title] Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcoma.
  • PURPOSE: We report here, our experience of seven patients with epithelioid sarcomas and their serum CA 125 levels, as well as the results of an in vitro and in vivo study of CA 125 expression in epithelioid sarcoma cells and xenografts using three epithelioid sarcoma cell lines.
  • METHODS: In the clinical study, the serum CA 125 levels of seven epithelioid sarcoma patients were examined at multiple time points.
  • Expression of the MUC16 gene that encodes the CA 125 sequence was examined using RT-PCR methods in three epithelioid sarcoma cell lines, FU-EPS-1, SFT-8606 and NEPS, and the CA 125 protein in each cell lysate was examined by Western blot using anti-CA 125 clone OC125 antibody.
  • RESULTS: In five of the seven epithelioid sarcoma patients, CA 125 levels reflected regression and progression of their disease.
  • CONCLUSION: We concluded that epithelioid sarcoma cells produce and secrete CA 125 into the blood serum and that the elevation of serum CA 125 correlates with disease progression.
  • Therefore, measuring the serum CA 125 level should provide an useful index for diagnosing and monitoring the course of epithelioid sarcoma.
  • [MeSH-major] CA-125 Antigen / blood. Monitoring, Physiologic / methods. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Animals. Biomarkers, Tumor / blood. Female. Foot / pathology. Forearm / pathology. Humans. Leg / pathology. Male. Mice. Mice, Inbred ICR. Mice, SCID. Prognosis. Thigh / pathology. Transplantation, Heterologous. Young Adult


46. Raoux D, Péoc'h M, Pedeutour F, Vaunois B, Decouvelaere AV, Folpe AL: Primary epithelioid sarcoma of bone: report of a unique case, with immunohistochemical and fluorescent in situ hybridization confirmation of INI1 deletion. Am J Surg Pathol; 2009 Jun;33(6):954-8
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  • [Title] Primary epithelioid sarcoma of bone: report of a unique case, with immunohistochemical and fluorescent in situ hybridization confirmation of INI1 deletion.
  • We report the clinical and pathologic features of, what is to the best of our knowledge, the first case of epithelioid sarcoma of bone.
  • Histologically, the tumor consisted of relatively uniform but clearly malignant-appearing epithelioid cells, with scattered rhabdoid-appearing cells.
  • An extensive clinical and radiographic workup did not show evidence of a soft tissue tumor, and the diagnosis of a primary epithelioid sarcoma of bone was made.
  • Awareness that epithelioid sarcoma may occur in bone, careful histologic evaluation and ancillary immunohistochemistry for epithelial markers, CD34 and INI1 protein should allow for recognition of such tumors.
  • Study of additional cases of primary epithelioid sarcoma of bone will be necessary to better understand its clinical behavior.
  • [MeSH-major] Bone Neoplasms / genetics. Bone Neoplasms / pathology. Chromosomal Proteins, Non-Histone / biosynthesis. Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / biosynthesis. DNA-Binding Proteins / genetics. Sarcoma / genetics. Sarcoma / pathology. Transcription Factors / biosynthesis. Transcription Factors / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Gene Deletion. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Tomography, X-Ray Computed

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  • (PMID = 19342946.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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47. Argenta PA, Thomas S, Chura JC: Proximal-type epithelioid sarcoma vs. malignant rhabdoid tumor of the vulva: a case report, review of the literature, and an argument for consolidation. Gynecol Oncol; 2007 Oct;107(1):130-5
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  • [Title] Proximal-type epithelioid sarcoma vs. malignant rhabdoid tumor of the vulva: a case report, review of the literature, and an argument for consolidation.
  • "Proximal" type epithelioid sarcoma (PES) and malignant rhabdoid tumor (MRT) describe a rare subset of vulvar malignancies which share histologic features and an aggressive clinical course.
  • [MeSH-major] Rhabdoid Tumor / therapy. Sarcoma / therapy. Vulvar Neoplasms / therapy
  • [MeSH-minor] Adult. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Prognosis. Radiotherapy, Adjuvant


48. Modena P, Lualdi E, Facchinetti F, Galli L, Teixeira MR, Pilotti S, Sozzi G: SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res; 2005 May 15;65(10):4012-9
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  • [Title] SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas.
  • Epithelioid sarcoma is a rare soft tissue neoplasm of uncertain lineage that usually arises in the distal extremities of adults, presents a high rate of recurrences and metastases and frequently poses diagnostic dilemmas.
  • We analyzed SMARCB1/INI1 gene status in nine additional epithelioid sarcoma cases (four proximal types and five conventional types) and altogether we identified deletions of SMARCB1/INI1 gene in 5 of 11 cases, all proximal types.
  • Overall, these results point to SMARCB1/INI1 gene involvement in the genesis and/or progression of epithelioid sarcomas.
  • Analysis of larger series of epithelioid sarcomas will be necessary to highlight putative clinically relevant features related to SMARCB1/INI1 inactivation.
  • [MeSH-major] DNA-Binding Proteins / genetics. Gene Expression Regulation, Neoplastic. Gene Silencing. Sarcoma / genetics
  • [MeSH-minor] Adult. Aged. Cell Line, Tumor. Chromosomal Proteins, Non-Histone. Chromosomes, Human, Pair 22 / genetics. Down-Regulation. Female. Gene Deletion. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors

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  • (PMID = 15899790.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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49. Henriques de Figueiredo B, Kantor G, Bui Nguyen Binh M, Duparc A, Guerder C, Stoeckle E, Coindre JM, Bui BN: [Epithelioid sarcoma: a retrospective study of conservative treatment with initial surgery and radiotherapy]. Cancer Radiother; 2007 Sep;11(5):227-33
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  • [Title] [Epithelioid sarcoma: a retrospective study of conservative treatment with initial surgery and radiotherapy].
  • INTRODUCTION: Epithelioid sarcoma is a rare type of soft tissue sarcomas with a high risk of recurrence both local and distant.
  • [MeSH-major] Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Female. Follow-Up Studies. Hand. Humans. Knee. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Pectoralis Muscles. Perineum. Postoperative Care. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 17652004.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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50. Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchère-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marquès B, Aubain Somerhausen Nde S, Keslair F, Pedeutour F, Coindre JM: Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group. Am J Surg Pathol; 2007 Sep;31(9):1387-402
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  • [Title] Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group.
  • Most relevant clinicopathologic features of fusion-positive LGFMS included predominance in lower extremities (22/48; thigh: 13/48), deep situation (46/48), and occasional presence of unusual histologic features, for example, hypercellular areas (16/48), foci of epithelioid cells (13/48), and giant rosettes (6/48).
  • Of all, 7/52 non-LGMFS neoplasms contained FUS-CREB3L2 transcripts, of which 4 had been diagnosed as sclerosing epithelioid fibrosarcoma.
  • The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related.
  • [MeSH-major] Basic-Leucine Zipper Transcription Factors / genetics. Biomarkers, Tumor / genetics. Cyclic AMP Response Element-Binding Protein / genetics. Epithelioid Cells / pathology. Fibroma / diagnosis. Fibrosarcoma / diagnosis. Gene Expression Regulation, Neoplastic. Nerve Tissue Proteins / genetics. RNA-Binding Protein FUS / genetics. Translocation, Genetic
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Child. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Molecular Sequence Data. Neoplasm Invasiveness. Paraffin Embedding. Predictive Value of Tests. RNA, Messenger / analysis. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 17721195.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic-Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / CREB3L1 protein, human; 0 / CREB3L2 protein, human; 0 / Cyclic AMP Response Element-Binding Protein; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / RNA-Binding Protein FUS
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51. Miettinen M, Fetsch JF: Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol; 2006 Apr;30(4):521-8
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  • [Title] Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases.
  • In this study, we analyzed a uniform group of 44 lesions composed of epithelioid histiocytes, comprising a subset of lesions originally designated as reticulohistiocytoma, and propose designating them as "solitary epithelioid histiocytoma" (SEH), in line with the recently published classification proposal for histiocytic disorders.
  • They were composed of large epithelioid histiocytes with a varying number of lymphocytes and neutrophils.
  • Immunohistochemically, the epithelioid histiocytes were positive for CD163, CD68, lysozyme (variably), and vimentin.
  • The epithelioid histiocytes were consistently negative for CD3, CD20, CD30, HMB45, and keratins.
  • It needs to be distinguished from Rosai-Dorfman disease, juvenile xanthogranuloma, a variety of granulomatous conditions, and some malignant neoplasms, including histiocytic sarcoma, melanoma, and epithelioid sarcoma.
  • [MeSH-major] Epithelioid Cells / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytosis, Sinus / diagnosis. Humans. Male. Middle Aged. Sarcoma / diagnosis. Sex Distribution. Xanthogranuloma, Juvenile / diagnosis

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  • (PMID = 16625100.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Nascimento AF, Bertoni F, Fletcher CD: Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. Am J Surg Pathol; 2007 Jan;31(1):99-105
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  • [Title] Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases.
  • Herein, we report a previously undescribed variant of MFS showing epithelioid morphology.
  • Seventeen cases diagnosed as epithelioid MFS were retrieved from the authors' files from among 570 cases of MFS.
  • Neoplastic cells were arranged singly and in small clusters in the myxoid areas or formed sheets in the hypercellular areas, where they showed epithelioid morphology with round nuclei, vesicular chromatin, prominent nucleoli, and moderate amounts of eosinophilic cytoplasm.
  • The epithelioid areas were generally multifocal with admixed areas of conventional MFS.
  • In conclusion, epithelioid MFS is a rare variant of MFS, accounting for <3% of MFS in consultation material.
  • [MeSH-major] Epithelioid Cells / pathology. Fibrosarcoma / secondary. Sarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Extremities. Fatal Outcome. Female. Humans. Immunoenzyme Techniques. Liposarcoma / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Myoepithelioma / diagnosis. Rhabdomyosarcoma / diagnosis

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  • (PMID = 17197925.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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53. Nishio J, Iwasaki H, Nabeshima K, Ishiguro M, Naumann S, Isayama T, Naito M, Kaneko Y, Kikuchi M, Bridge JA: Establishment of a new human epithelioid sarcoma cell line, FU-EPS-1: molecular cytogenetic characterization by use of spectral karyotyping and comparative genomic hybridization. Int J Oncol; 2005 Aug;27(2):361-9
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  • [Title] Establishment of a new human epithelioid sarcoma cell line, FU-EPS-1: molecular cytogenetic characterization by use of spectral karyotyping and comparative genomic hybridization.
  • A small number of human epithelioid sarcoma cell lines have been reported, but their characterization at a molecular cytogenetic level is not well known.
  • In this study, a new permanent human cell line, FU-EPS-1, derived from a metastatic epithelioid sarcoma developing in the axillary lymph node of a 21-year-old man is described.
  • Histologic features of the heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor, revealing a multinodular proliferation of eosinophilic epithelioid and spindle cells.
  • The FU-EPS-1 cell line will be exceedingly useful for biologic and molecular pathogenetic studies of human epithelioid sarcoma.
  • [MeSH-major] Cell Line, Tumor. Sarcoma / pathology
  • [MeSH-minor] Adult. Animals. Antigens, CD34 / analysis. Biomarkers / analysis. Cell Proliferation. Female. Genome, Human. Humans. Immunohistochemistry. Keratins / analysis. Male. Mice. Mice, Nude. Mice, SCID. Mucin-1 / analysis. Neoplasm Transplantation. Nucleic Acid Hybridization / methods. Sarcoma, Experimental / genetics. Sarcoma, Experimental / metabolism. Sarcoma, Experimental / pathology. Spectral Karyotyping / methods. Time Factors. Transplantation, Heterologous. Vimentin / analysis

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  • (PMID = 16010416.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA 36727
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins
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54. Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, Rosenberg AE, Nielsen GP, DeLaney TF, Chen YL, Ott MJ, Yoon SS: Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol; 2009 May;16(5):1356-63
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  • [Title] Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas.
  • BACKGROUND: Soft tissue sarcomas generally have a </=5% risk of lymph node metastasis, but synovial, epithelioid, and clear cell subtypes reportedly have a much higher risk.
  • The utility of sentinel lymph node biopsy (SLNB) for patients with these sarcoma subtypes is unknown.
  • METHODS: 29 patients with nonmetastatic synovial, epithelioid, and clear cell sarcomas who underwent SLNB were examined.
  • The histological subtypes were synovial sarcoma in 16 patients, epithelioid sarcoma in 10, and clear cell sarcoma in 3.
  • CONCLUSION: For patients with these sarcoma subtypes without radiological evidence of nodal or distant metastases, the incidence of occult lymph node metastasis is relatively low.
  • [MeSH-major] Sarcoma / pathology. Sarcoma, Clear Cell / pathology. Sarcoma, Synovial / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Extremities. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Young Adult

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  • (PMID = 19259743.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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55. Koga T, Ushijima K, Kage M, Ichiki M, Kitajima T, Narita Y, Mizoguchi Y, Hanada M, Ehara R, Nishimura M, Takamori S, Aizawa H: Pulmonary metastasis of endometrial stromal sarcoma. Kurume Med J; 2006;53(3-4):95-7
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  • [Title] Pulmonary metastasis of endometrial stromal sarcoma.
  • Morphological characteristics of the thracoscopically resected lung tumors suggested low-grade endometrial stromal sarcoma (ESS), and immunostaining revealed that the tumor cells were positive for progesterone and estrogen receptors, CD10 and vimentin, confirming a diagnosis of ESS.
  • ESS is an uncommon uterine neoplasm, however, may be mistaken as benign tumors such as epithelioid leiomyoma, and occasionally metastasizes to remote organs such as lungs even after long disease-free period, posing diagnostic challenge.
  • [MeSH-major] Endometrial Neoplasms / pathology. Lung Neoplasms / secondary. Sarcoma, Endometrial Stromal / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 17317938.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Gagner JP, Yim JH, Yang GC: Fine-needle aspiration cytology of epithelioid angiosarcoma: a diagnostic dilemma. Diagn Cytopathol; 2005 Dec;33(6):429-33

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  • [Title] Fine-needle aspiration cytology of epithelioid angiosarcoma: a diagnostic dilemma.
  • On the basis of cytologic features on smears, high-grade sarcoma was reported.
  • The case was sent for expert consultation, and the expert's opinion was epithelioid angiosarcoma.
  • The clinical presentation, cytology, histology, and immunohistochemistry of the current case and 15 other cases of epithelioid angiosarcoma found in the cytology literature are summarized.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Diagnostic Errors. Epithelioid Cells / pathology. Female. Humans. Immunohistochemistry. Venous Thrombosis / radiography

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  • (PMID = 16299742.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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57. Kim JY, Cho YM, Ro JY: Prostatic stromal sarcoma with rhabdoid features. Ann Diagn Pathol; 2010 Dec;14(6):453-6
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  • [Title] Prostatic stromal sarcoma with rhabdoid features.
  • A needle biopsy was diagnosed as an unclassified spindle cell sarcoma, and 2 cycles of adriamycin-based neoadjuvant chemotherapy were given, followed by radical prostatectomy.
  • The prostatectomy specimen revealed a high-grade sarcoma with fascicles of highly cellular spindle cells and numerous mitoses with hemorrhage and necrosis.
  • In areas, the tumor also contained sheets of loosely cohesive epithelioid cells with rhabdoid tumor component.
  • [MeSH-major] Prostatic Neoplasms / pathology. Rhabdoid Tumor / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Fatal Outcome. Humans. Male. Receptors, Progesterone / metabolism. Vimentin / metabolism

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21074696.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Receptors, Progesterone; 0 / Vimentin
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58. Hong B, Hermann EJ, Hollwitz B, Klein R, Agaronjan A, Krauss JK: Primary meningeal sarcoma with leiomyoblastic differentiation complicating pregnancy. Clin Neurol Neurosurg; 2010 Jul;112(6):516-9
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  • [Title] Primary meningeal sarcoma with leiomyoblastic differentiation complicating pregnancy.
  • Primary meningeal sarcoma with leiomyoblastic differentiation during pregnancy has not been reported.
  • Histological examination revealed primary meningeal sarcoma with leiomyoblastic differentiation.
  • [MeSH-major] Leiomyoma, Epithelioid / complications. Meningeal Neoplasms / complications. Pregnancy Complications, Neoplastic / pathology. Sarcoma / complications
  • [MeSH-minor] Adult. Brain / pathology. Cesarean Section. Combined Modality Therapy. Fatal Outcome. Female. Humans. Infant, Newborn. Magnetic Resonance Imaging. Pregnancy. Pregnancy Outcome

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20399009.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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59. Rekhi B, Gorad BD, Chinoy RF: Clinicopathological features with outcomes of a series of conventional and proximal-type epithelioid sarcomas, diagnosed over a period of 10 years at a tertiary cancer hospital in India. Virchows Arch; 2008 Aug;453(2):141-53
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  • [Title] Clinicopathological features with outcomes of a series of conventional and proximal-type epithelioid sarcomas, diagnosed over a period of 10 years at a tertiary cancer hospital in India.
  • Epithelioid sarcoma (ES) is an uncommon sarcoma.
  • This unusual sarcoma, with characteristic growth patterns, merits a proper histological evaluation, as it has many mimics.
  • [MeSH-major] Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Arm / pathology. Child. Female. Humans. India / epidemiology. Kaplan-Meier Estimate. Leg / pathology. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 18607629.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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60. Brimo F, Nahal A: Malignant epithelioid hemangioendothelioma with spindle phenotype: report of an unusual case diagnosed by fine needle aspiration cytology. Acta Cytol; 2008 Nov-Dec;52(6):721-4
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  • [Title] Malignant epithelioid hemangioendothelioma with spindle phenotype: report of an unusual case diagnosed by fine needle aspiration cytology.
  • BACKGROUND: Epithelioid hemangioendothelioma (EHE) is a rare sarcoma of vascular differentiation that involves various sites and is rarely diagnosed by cytology.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Hemangioendothelioma, Epithelioid / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Female. Humans. Necrosis. Phenotype. Thigh

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  • (PMID = 19068679.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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61. Svec A, Velenská Z: Renal epithelioid angiomyolipoma--a close mimic of renal cell carcinoma. Report of a case and review of the literature. Pathol Res Pract; 2005;200(11-12):851-6
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  • [Title] Renal epithelioid angiomyolipoma--a close mimic of renal cell carcinoma. Report of a case and review of the literature.
  • The epithelioid variant of angiomyolipoma (EAML) is a rare tumor of unpredictable behavior that is composed of epithelioid, spindle, and giant cells and contains no or only a minimal amount of lipomatous tissue.
  • The picture can lead to an erroneous diagnosis of renal cell carcinoma or sarcoma.
  • Histologically, it was solid, highly cellular, with occasional microcysts, composed of medium to large epithelioid cells with clear or oxyphilic cytoplasm, short spindle cells, and numerous giant multinucleated cells.
  • After extensive sampling, adult-appearing fat tissue was found to present as rare foci of microscopic dimensions.
  • [MeSH-major] Angiomyolipoma / pathology. Carcinoma, Renal Cell / diagnosis. Epithelioid Cells / pathology. Kidney Neoplasms / pathology

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  • (PMID = 15792132.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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62. Talbot SG, Mehrara BJ, Disa JJ, Wong AK, Pusic A, Cordeiro PG, Athanasian EA: Soft-tissue coverage of the hand following sarcoma resection. Plast Reconstr Surg; 2008 Feb;121(2):534-43
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  • [Title] Soft-tissue coverage of the hand following sarcoma resection.
  • The authors review the experience at a single institution of hand reconstruction following sarcoma resection based on prospectively collected data.
  • METHODS: Data were collected for all patients undergoing sarcoma resection by a single surgeon.
  • The most common abnormalities were epithelioid sarcoma (n = 9), soft-tissue malignant fibrous histiocytoma (n = 8), synovial sarcoma (n = 6), and fibrosarcoma (n = 4).
  • CONCLUSIONS: The choice of hand reconstruction method following sarcoma resection depends on a complete knowledge of options, risks, and benefits.
  • [MeSH-major] Hand. Reconstructive Surgical Procedures / methods. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Amputation / methods. Biopsy. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Retrospective Studies. Surgical Flaps. Survival Rate. Treatment Outcome. United States / epidemiology


63. Reis C, Carneiro E, Fonseca J, Pereira P, Vaz R, Pinto R, Capelinha AF, Lopes JM, Salgado A: Epithelioid hemangioendothelioma and multiple thoraco-lumbar lateral meningoceles: two rare pathological entities in a patient with NF-1. Neuroradiology; 2005 Feb;47(2):165-9
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  • [Title] Epithelioid hemangioendothelioma and multiple thoraco-lumbar lateral meningoceles: two rare pathological entities in a patient with NF-1.
  • Epithelioid hemangioendothelioma (EHE) is a rare vascular soft-tissue tumour of intermediate malignancy.
  • Neurofibromatosis type I (NF-1) is a genetic syndrome associated with soft tissue sarcoma and higher risk of developing neoplasia.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / etiology. Meningocele / etiology. Neurofibromatosis 1 / complications. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Lumbar Vertebrae. Thoracic Vertebrae

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  • (PMID = 15688204.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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64. Kohashi K, Oda Y, Yamamoto H, Tamiya S, Matono H, Iwamoto Y, Taguchi T, Tsuneyoshi M: Reduced expression of SMARCB1/INI1 protein in synovial sarcoma. Mod Pathol; 2010 Jul;23(7):981-90
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  • [Title] Reduced expression of SMARCB1/INI1 protein in synovial sarcoma.
  • Synovial sarcoma is classified as a tumor of uncertain differentiation, and some synovial sarcomas have rhabdoid cells.
  • In previous studies, all malignant rhabdoid tumors and renal medullary carcinomas, some extraskeletal myxoid chondrosarcomas, almost all epithelioid sarcomas and half of epithelioid malignant peripheral nerve sheath tumors showed a loss of SMARCB1/INI1 protein expression in tumor cells and all of these tumors are also known to have rhabdoid cells.
  • We analyzed the immunohistochemical and mRNA expression of SMARCB1/INI1 in 95 synovial sarcomas (73 monophasic fibrous type, 18 biphasic type and 4 poorly differentiated type) and 30 spindle cell sarcomas (3 adult fibrosarcomas, 7 fibrosarcomas arising in dermatofibrosarcoma protuberans, 10 leiomyosarcomas and 10 malignant peripheral nerve sheath tumors) resembling monophasic fibrous synovial sarcoma.
  • The results have shown that 66 of the 95 synovial sarcoma cases (69%) had reduced SMARCB1/INI1 protein expression, whereas the remaining 29 cases (31%) and all 30 spindle cell sarcomas showed preserved this protein expression.
  • The median values of SMARCB1/INI1 mRNA expression in non-tumor skeletal muscle and synovial sarcoma with reduced protein expression were 12.86 and 134.01, respectively, and a statistically significant difference was detected between these two groups (P=0.0000004).
  • However, there was no statistically significant difference of prognosis between the synovial sarcoma group with reduced and that with preserved SMARCB1/INI1 protein expression (P=0.46).
  • Therefore, it was suggested that there is a post-transcriptional SMARCB1/INI1 regulatory mechanism in the tumor cells of synovial sarcoma.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / biosynthesis. DNA-Binding Proteins / biosynthesis. Sarcoma, Synovial / metabolism. Sarcoma, Synovial / pathology. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology. Transcription Factors / biosynthesis

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  • (PMID = 20305614.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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65. Córdoba-Fernández A, Juárez-Jiménez JM, Mazuecos-Blanca J, Illanes-Moreno M: A report of a rare case of myxoinflammatory fibroblastic sarcoma. J Am Podiatr Med Assoc; 2010 Nov-Dec;100(6):497-501
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  • [Title] A report of a rare case of myxoinflammatory fibroblastic sarcoma.
  • Myxoinflammatory fibroblastic sarcoma of the soft tissues is a rare low-grade tumor of uncertain origin that most often occurs on the extremities of adults.
  • Despite being a rare neoplasm, owing to its varied histologic appearance, myxoinflammatory fibroblastic sarcoma should be differentiated from various benign and malignant soft-tissue lesions.
  • Myxoinflammatory fibroblastic sarcoma has been well described in pathology journals but not in the surgical literature.
  • We report a case of myxoinflammatory fibroblastic sarcoma in a 19-year-old man with a plantar ulcer lesion in his left foot.
  • [MeSH-major] Foot Diseases / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Epithelioid Cells / pathology. Fibroblasts / pathology. Foot Ulcer / etiology. Foot Ulcer / pathology. Humans. Immunohistochemistry. Inflammation / pathology. Male

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  • [ErratumIn] J Am Podiatr Med Assoc. 2011 Jan-Feb;101(1):84. Córdoba, Antonio [corrected to Córdoba-Fernández, Antonio]
  • (PMID = 21084537.001).
  • [ISSN] 1930-8264
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Zheng JM, Tao X, Xu AM, Chen XF, Wu MC, Zhang SH: Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. Histopathology; 2007 Aug;51(2):195-203
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  • [Title] Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis.
  • AIMS: To evaluate primary and recurrent embryonal sarcoma of the liver and to improve recognition of its morphological variants and immunohistochemical features.
  • METHODS AND RESULTS: Fourteen primary and two recurrent cases of hepatic embryonal sarcoma were evaluated histologically and investigated immunohistochemically with a panel of antibodies using the EnVision+ system.
  • Microscopic features included spindle, oval, stellate, epithelioid or multinucleated cells loosely or densely arranged in a myxomatous matrix.
  • CONCLUSIONS: Embryonal sarcoma of the liver may undergo pluripotential differentiation and diagnosis should be based mainly on morphological features.
  • [MeSH-minor] Actins / metabolism. Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Differentiation. Child. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Proteins / metabolism. alpha 1-Antitrypsin / metabolism. alpha-Fetoproteins

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  • (PMID = 17573940.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / Actins; 0 / Biomarkers, Tumor; 0 / Proteins; 0 / alpha 1-Antitrypsin; 0 / alpha-Fetoproteins
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67. Kiani B, Ferrell LD, Qualman S, Frankel WL: Immunohistochemical analysis of embryonal sarcoma of the liver. Appl Immunohistochem Mol Morphol; 2006 Jun;14(2):193-7
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  • [Title] Immunohistochemical analysis of embryonal sarcoma of the liver.
  • Embryonal sarcoma of the liver is a rare, aggressive malignant tumor that typically occurs in children and teenagers.
  • Tumors ranged from 10 to 20 cm and contained spindled and epithelioid areas with PAS-positive, diastase-resistant globules and atypical cells with focal multinucleation.
  • The diagnosis of embryonal sarcoma is based on typical morphologic features in a large liver tumor occurring in a young patient.

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  • (PMID = 16785789.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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68. Jun L, Ke S, Zhaoming W, Linjie X, Xinru Y: Primary synovial sarcoma of the prostate: report of 2 cases and literature review. Int J Surg Pathol; 2008 Jul;16(3):329-34
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  • [Title] Primary synovial sarcoma of the prostate: report of 2 cases and literature review.
  • Two cases of primary prostatic synovial sarcoma presenting as a prostatic mass are presented in patients aged 44 and 46 years.
  • Clusters of immature epithelioid cells were also observed among the spindle cells in case 1.
  • To the authors' knowledge, these represent the fifth and sixth reported cases of prostatic synovial sarcoma.
  • [MeSH-major] Prostatic Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chromosomes, Human, Pair 18. Chromosomes, Human, X. DNA, Neoplasm / analysis. Epithelioid Cells / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Oncogene Proteins, Fusion / analysis. Reverse Transcriptase Polymerase Chain Reaction. Translocation, Genetic

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  • (PMID = 18387992.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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69. Kovarik CL, Barrett T, Auerbach A, Cassarino DS: Acral myxoinflammatory fibroblastic sarcoma: case series and immunohistochemical analysis. J Cutan Pathol; 2008 Feb;35(2):192-6
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  • [Title] Acral myxoinflammatory fibroblastic sarcoma: case series and immunohistochemical analysis.
  • BACKGROUND: Acral myxoinflammatory fibroblastic sarcoma (AMFS) is a rare, low-grade neoplasm most often occurring on the extremities of adults.
  • It consists of mixed inflammatory infiltrates with nodules of epithelioid, spindled and bizarre-appearing cells within a fibrosclerotic-to-myxoid stroma.
  • Histologic characteristics included the presence of fibrosclerotic and myxoid stroma, sheets of spindled to round epithelioid cells, Reed-Sternberg or virocyte-like cells, lipoblast-like cells and rare mitotic figures.
  • [MeSH-major] Sarcoma / metabolism. Sarcoma / pathology. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / biosynthesis. Antigens, CD34 / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. Diagnosis, Differential. Female. Fibrosarcoma / metabolism. Fibrosarcoma / pathology. Fingers / pathology. Foot / pathology. Hand / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / biosynthesis. Lymphoma / pathology. Male. Middle Aged. Proto-Oncogene Proteins c-kit / biosynthesis. Receptor, Epidermal Growth Factor / biosynthesis. Receptors, Cell Surface / biosynthesis. Toes / pathology. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 18190444.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD163 antigen; 0 / Ki-67 Antigen; 0 / Receptors, Cell Surface; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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70. Tu XY, Sheng WQ, Lu HF, Wang J: [Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Oct;36(10):660-5

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  • [Title] [Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma].
  • OBJECTIVE: To study the clinicopathologic features and immunophenotype of intraabdominal extranodal follicular dendritic cell sarcoma (FDCS) and the relationship with Epstein-Barr virus (EBV).
  • Histologically, there were plump spindle, ovoid to epithelioid cells associated with scattered multinucleated giant cells.
  • [MeSH-major] Abdominal Neoplasms / pathology. Dendritic Cell Sarcoma, Follicular / pathology. Epstein-Barr Virus Infections. Receptors, Complement 3d / metabolism. Receptors, IgE / metabolism
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Gastrointestinal Stromal Tumors / pathology. Granuloma, Plasma Cell / pathology. Humans. Immunophenotyping. Male. Middle Aged. Vimentin / metabolism

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  • (PMID = 18194598.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Receptors, Complement 3d; 0 / Receptors, IgE; 0 / Vimentin
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71. Tong GX, Goldblum JR, Qiu W, Skacel M, Downs-Kelly E, Contractor S, Levine P: Primary intravascular synovial sarcoma: a disease of young adult women? Report of a case diagnosed by aspiration biopsy and review of the literature. Diagn Cytopathol; 2006 Dec;34(12):834-8
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  • [Title] Primary intravascular synovial sarcoma: a disease of young adult women? Report of a case diagnosed by aspiration biopsy and review of the literature.
  • Intravascular synovial sarcoma (IVSS) is an extremely rare tumor with only four well-documented cases in the English literature.
  • A fine-needle aspiration biopsy (FNAB) was performed and showed a malignant biphasic tumor with spindle cell and epithelioid components.
  • A diagnosis of synovial sarcoma was made and confirmed in a subsequent transvascular biopsy demonstrating chromosomal translocation t(X, 18) by fluorescence in situ hybridization using a dual color, break-apart-style probe for SYT.
  • [MeSH-major] Sarcoma, Synovial / diagnosis. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Age Factors. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Sex Factors. Translocation, Genetic

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17183757.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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72. Herzog CE: Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol; 2005 Apr;27(4):215-8
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  • [Title] Overview of sarcomas in the adolescent and young adult population.
  • However, there are numerous different histologic types, and any given type of sarcoma is extremely rare.
  • In an effort to estimate the frequency and absolute numbers of different sarcomas in the adolescent and young adult population, the University of Texas M. D.
  • Based on this query, an overview of sarcomas that occur predominantly in the adolescent and young adult (AYA) population is presented.
  • These sarcomas include rhabdomyosarcoma, synovial sarcoma, neurogenic sarcoma, epithelioid sarcomas, alveolar soft parts sarcoma, Ewing sarcoma, and osteosarcoma.
  • Using the percentages for occurrence of each histologic type determined from the MDACC database, and the SEER estimate of overall sarcoma incidence, an estimate of the number of new cases in 2004 for the predominant histologic types occurring in the AYA population are presented.
  • [MeSH-major] Bone Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Humans. Middle Aged. SEER Program

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  • (PMID = 15838394.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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73. Huang W, Zhang X, Li D, Chen J, Meng K, Wang Y, Lu Z, Zhou X: Osteoclast-rich tumor of the gastrointestinal tract with features resembling those of clear cell sarcoma of soft parts. Virchows Arch; 2006 Feb;448(2):200-3

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  • [Title] Osteoclast-rich tumor of the gastrointestinal tract with features resembling those of clear cell sarcoma of soft parts.
  • Clear cell sarcoma is a high-grade sarcoma with morphological features resembling those of malignant melanoma.
  • The differential diagnosis included gastrointestinal stromal tumor, primary or metastatic melanoma, and epithelioid malignant peripheral nerve sheath tumor.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Osteoclasts / pathology. Sarcoma, Clear Cell / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Diagnosis, Differential. Giant Cells / chemistry. Giant Cells / pathology. Humans. Immunohistochemistry. Male. S100 Proteins / analysis

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  • (PMID = 16220298.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / S100 Proteins
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74. Grivas A, Trafalis DT, Thanopoulou E, Ziras NG, Athanasiou AE: Treatment with trabectedin: should be indicated to all soft tissue sarcoma histotypes? J BUON; 2010 Oct-Dec;15(4):791-3
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  • [Title] Treatment with trabectedin: should be indicated to all soft tissue sarcoma histotypes?
  • Trabectedin is a novel antineoplastic agent approved as monotherapy in patients with advanced soft tissue sarcoma (STS) after failure of standard therapy with anthracyclines or ifosfamide, or patients who are unsuited to receive these agents.
  • We report on two patients suffering from infrequent subtypes of STSs, fibrosarcoma and epithelioid sarcoma, who were treated with trabectedin.
  • [MeSH-major] Antineoplastic Agents, Alkylating / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dioxoles / adverse effects. Fibrosarcoma / drug therapy. Sarcoma / drug therapy. Tetrahydroisoquinolines / adverse effects
  • [MeSH-minor] Adult. Female. Humans. Lung Neoplasms / chemically induced. Lung Neoplasms / secondary. Male. Prognosis

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  • (PMID = 21229647.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Dioxoles; 0 / Tetrahydroisoquinolines; 114899-77-3 / trabectedin
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75. Huang SC, Chang CL, Huang CH, Chang CC: Histiocytic sarcoma - a case with evenly distributed multinucleated giant cells. Pathol Res Pract; 2007;203(9):683-9
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  • [Title] Histiocytic sarcoma - a case with evenly distributed multinucleated giant cells.
  • Histiocytic sarcoma is an uncommon neoplasm of mature histiocytes with a poor clinical outcome.
  • We report a case of a true histiocytic sarcoma with prominent and evenly distributed multinucleated giant cells that mimics a giant cell tumor of soft tissue.
  • Microscopically, polygonal mononuclear tumor cells aggregated to form somewhat epithelioid nests, which occasionally showed coagulative necrosis.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Giant Cells / pathology. Histiocytes / pathology. Histiocytic Disorders, Malignant / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Adult. Antigens, CD / analysis. Cell Lineage. Diagnosis, Differential. Female. Humans. Muramidase / analysis. Neoplasm Invasiveness. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17673373.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; EC 3.2.1.17 / Muramidase
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76. Saithna A, Pynsent PB, Grimer RJ: Retrospective analysis of the impact of symptom duration on prognosis in soft tissue sarcoma. Int Orthop; 2008 Jun;32(3):381-4
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  • [Title] Retrospective analysis of the impact of symptom duration on prognosis in soft tissue sarcoma.
  • The objective was to assess whether time to diagnosis is influenced by patient/tumour-related factors and whether or not duration of symptoms has any impact on survival in soft tissue sarcoma.
  • Patient and tumour-related factors significantly associated with longer symptom duration were low-grade, subcutaneous tumours, and epithelioid or synovial sarcoma.
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Factors. Time Factors

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  • [Cites] J Clin Oncol. 2002 Nov 1;20(21):4344-52 [12409334.001]
  • [Cites] Eur J Surg Oncol. 2003 Jun;29(5):440-5 [12798748.001]
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  • (PMID = 17377790.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2323426
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77. Wang XI, Zhang S, Thomas JO, Adegboyega PA: Cytomorphology, ultrastructural, and cytogenetic findings in follicular dendritic cell sarcoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):759-63
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  • [Title] Cytomorphology, ultrastructural, and cytogenetic findings in follicular dendritic cell sarcoma: a case report.
  • BACKGROUND: Follicular dendritic cell (FDC) sarcoma is a rare low-to-intermediate grade malignant dendritic cell neoplasm that often has an indolent clinical course.
  • Fine needle aspiration cytology revealed many large, spindle to ovoid epithelioid cells in singles, small clusters, and syncytial sheets with moderate to abundant cytoplasm, indistinct cell borders, irregular nuclear membrane, fine to vesicular chromatin, and conspicuous nucleoli.
  • The background contained many small mature lymphocytes intimately mixed with large epithelioid tumor cells.
  • Diagnosis of FDC sarcoma was rendered; follow-up surgical resection and ultrastructural study confirmed the diagnosis.
  • CONCLUSION: Although the cytomorphology of FDC sarcoma is characteristic, a preoperative diagnosis of FDC sarcoma based on fine needle aspiration cytology is very challenging, if not impossible.
  • [MeSH-major] Cytogenetic Analysis. Dendritic Cell Sarcoma, Follicular / genetics. Dendritic Cell Sarcoma, Follicular / pathology. Dendritic Cells, Follicular / pathology. Dendritic Cells, Follicular / ultrastructure
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Cell Proliferation. Desmosomes / ultrastructure. Humans. Neck / pathology

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  • (PMID = 21053535.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Zhao H, Cai JQ, Bi XY, Zhao JJ, Huang Z, Lu HZ, Zhou HT: [Diagnosis,treatment, and prognostic of liver sarcoma: analysis of 16 cases]. Zhonghua Yi Xue Za Zhi; 2008 Jun 10;88(22):1537-9
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  • [Title] [Diagnosis,treatment, and prognostic of liver sarcoma: analysis of 16 cases].
  • OBJECTIVE: To explore the diagnosis, treatment, and prognostic factors of liver sarcoma.
  • METHODS: The clinical data of 16 liver sarcoma patients, 9 males and 7 females, aged 46.7 (12-73), treated 1980-2005, were analyzed retrospectively.
  • Pathological analysis diagnosed 6 patients (37.5%) as with leiomyosarcoma, 5 patients (31.25%) with angiosarcoma, 2 patients (12.5%) with fibrosarcoma, 1 patient (12.5%) with epithelioid hemangioendothelioma, 1 patient (12.5%) with myxoid liposarcoma, and 1 patient (12.5%) with undifferentiated embryonal sarcoma.
  • CONCLUSION: Liver sarcoma is difficult to be diagnosed preoperatively.
  • Surgical resection is the mainstay of the treatment of liver sarcoma.
  • [MeSH-major] Liver Neoplasms / diagnosis. Liver Neoplasms / surgery. Sarcoma / diagnosis. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Prognosis. Survival Analysis. Young Adult

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  • (PMID = 18956634.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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79. Périgny M, Dion N, Couture C, Lagacé R: [Low grade fibromyxoid sarcoma: a clinico-pathologic analysis of 7 cases]. Ann Pathol; 2006 Dec;26(6):419-25
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  • [Title] [Low grade fibromyxoid sarcoma: a clinico-pathologic analysis of 7 cases].
  • OBJECTIVES: Low-grade fibromyxoid sarcoma (LGFMS) is a malignant soft tissue tumor.
  • One of them demonstrated an area of dedifferentiation into a high grade pleomorphic sarcoma, malignant fibrous histiocytoma (MFH) type.
  • We report a unique case with areas of high grade sarcoma, MFH type, and areas similar to sclerosing epithelioid fibrosarcoma.
  • [MeSH-major] Fibroma / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17255901.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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80. Niimi R, Matsumine A, Kusuzaki K, Okamura A, Matsubara T, Uchida A, Fukutome K: Soft-tissue sarcoma mimicking large haematoma: a report of two cases and review of the literature. J Orthop Surg (Hong Kong); 2006 Apr;14(1):90-5
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  • [Title] Soft-tissue sarcoma mimicking large haematoma: a report of two cases and review of the literature.
  • In the second patient with epithelioid sarcoma of the forearm, fasciotomy was repeatedly performed for compartment syndrome arising from the tumour.
  • [MeSH-major] Buttocks. Forearm. Hematoma / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 16598096.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 26
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81. Fleshman R, Mayerson J, Wakely PE Jr: Fine-needle aspiration biopsy of high-grade sarcoma: a report of 107 cases. Cancer; 2007 Dec 25;111(6):491-8
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  • [Title] Fine-needle aspiration biopsy of high-grade sarcoma: a report of 107 cases.
  • BACKGROUND: To the authors' knowledge, few studies exist demonstrating the reliability of fine-needle aspiration (FNA) biopsy for high-grade sarcoma (HGS).
  • Fifty-four cases were diagnosed as HGS, not otherwise specified, 8 as myxofibrosarcoma, 8 as osteosarcoma, 5 as malignant peripheral nerve sheath tumor, 5 as leiomyosarcoma, 4 as Ewing sarcoma, 4 as liposarcoma, 2 as epithelioid sarcoma, and 1 as angiosarcoma.
  • [MeSH-major] Biopsy, Fine-Needle. Cytodiagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Bone Neoplasms / diagnosis. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Predictive Value of Tests. Reproducibility of Results

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  • (PMID = 17941014.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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82. Billings SD, Giblen G, Fanburg-Smith JC: Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population. Am J Surg Pathol; 2005 Feb;29(2):204-10
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  • [Title] Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population.
  • Low-grade fibromyxoid sarcoma (LGFMS), usually a deeply situated mass in adults, is uncommon in superficial soft tissue and in children.
  • Clinical and histologic submitting diagnoses were mainly benign except for 3 cases, submitted as low-grade sarcoma, with only one as superficial LGFMS.
  • Collagen rosettes with peripheral round epithelioid cells and focal ischemic necrosis were present in 6 cases each.
  • [MeSH-major] Fibroma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15644777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Sebenik M, Ricci A Jr, DiPasquale B, Mody K, Pytel P, Jee KJ, Knuutila S, Scholes J: Undifferentiated intimal sarcoma of large systemic blood vessels: report of 14 cases with immunohistochemical profile and review of the literature. Am J Surg Pathol; 2005 Sep;29(9):1184-93
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  • [Title] Undifferentiated intimal sarcoma of large systemic blood vessels: report of 14 cases with immunohistochemical profile and review of the literature.
  • Intimal sarcoma (IS) is defined as a malignant tumor arising in the tunica intima of large blood vessels.
  • Histopathology was that of a largely necrotic, poorly differentiated epithelioid and pleomorphic malignant neoplasm relating to the tunica intima.
  • Such extravascular tumors assumed a variety of patterns reminiscent of undifferentiated pleomorphic sarcoma (UPS; in older literature also known as pleomorphic malignant fibrous histiocytoma, MFH) or other distinct types of sarcomas, including osteosarcoma, angiosarcoma, and rhabdomyosarcoma.
  • UIS of large systemic vessels represents a distinct clinical entity where intraluminal sarcoma presents with thrombosis and occlusion of large vessels.
  • [MeSH-major] Blood Vessels / pathology. Sarcoma / pathology. Tunica Intima / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD31 / metabolism. Diagnosis, Differential. Female. Gelsolin / metabolism. Humans. Immunohistochemistry. Male. Microfilament Proteins. Microscopy, Electron, Transmission. Middle Aged. Nucleic Acid Hybridization. Receptors, Cytoplasmic and Nuclear / metabolism

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  • (PMID = 16096408.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / FLII protein, human; 0 / Gelsolin; 0 / Microfilament Proteins; 0 / Receptors, Cytoplasmic and Nuclear
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84. Jiang J, Zhou J, Ding W: Primary pulmonary synovial sarcoma, a rare primary lung neoplasm: two case reports and review of the current literature. Respirology; 2008 Sep;13(5):748-50
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  • [Title] Primary pulmonary synovial sarcoma, a rare primary lung neoplasm: two case reports and review of the current literature.
  • This report describes the clinical, histological and immunohistochemical features of two patients with primary pulmonary synovial sarcoma in the context of the literature.
  • Diagnosis depends on identifying epithelioid or spindle cells microscopically and on immunohistochemistry showing positivity for cytokeratin and vimentin and epithelial membrane antigen stains.
  • [MeSH-major] Lung Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adult. Chest Pain / etiology. Cough / etiology. Humans. Keratins / metabolism. Male. Middle Aged. Vimentin / metabolism

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  • (PMID = 18713096.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 10
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85. Zheng YY, Zhou XG, Zhang SH, Zhang YN: [Histiocytic sarcoma: a clinicopathologic study of 6 cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Feb;39(2):79-83
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  • [Title] [Histiocytic sarcoma: a clinicopathologic study of 6 cases].
  • OBJECTIVE: To study the morphologic features, immunophenotypes, differential diagnoses and prognosis of histiocytic sarcoma (HS).
  • The tumor was composed of sheets of large epithelioid cells with abundant eosinophilic cytoplasm, oval to irregular nuclei, vesicular chromatin and large nucleoli.
  • [MeSH-major] Histiocytic Sarcoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large-Cell, Anaplastic / metabolism. Lymphoma, Large-Cell, Anaplastic / pathology. Male. Melanoma / metabolism. Melanoma / pathology. Muramidase / metabolism. Prognosis. Receptors, Cell Surface / metabolism. Young Adult

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  • (PMID = 20388371.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD163 antigen; 0 / CD68 antigen, human; 0 / Receptors, Cell Surface; EC 3.2.1.17 / Muramidase
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86. Vermi W, Lonardi S, Bosisio D, Uguccioni M, Danelon G, Pileri S, Fletcher C, Sozzani S, Zorzi F, Arrigoni G, Doglioni C, Ponzoni M, Facchetti F: Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. J Pathol; 2008 Nov;216(3):356-64
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  • [Title] Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma.
  • In contrast, no data are available on CXCL13 expression on FDC sarcoma (FDC-S) cells.
  • In addition to the potential biological relevance of this expression, the use of reagents directed against CXCL13 can be useful to properly identify the origin of spindle cell and epithelioid neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Chemokine CXCL13 / analysis. Dendritic Cells, Follicular / immunology. Sarcoma / immunology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Giant Lymph Node Hyperplasia / immunology. Humans. Immunohistochemistry. In Situ Hybridization / methods. Lymph Nodes / immunology. Male. Middle Aged. Palatine Tonsil / immunology. RNA, Messenger / analysis. Receptors, CXCR5 / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. T-Lymphocytes / metabolism

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  • [Copyright] (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 18792075.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CXCL13 protein, human; 0 / Chemokine CXCL13; 0 / RNA, Messenger; 0 / Receptors, CXCR5
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87. Hisaoka M, Ishida T, Kuo TT, Matsuyama A, Imamura T, Nishida K, Kuroda H, Inayama Y, Oshiro H, Kobayashi H, Nakajima T, Fukuda T, Ae K, Hashimoto H: Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases. Am J Surg Pathol; 2008 Mar;32(3):452-60
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  • [Title] Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases.
  • Clear cell sarcoma (CCS) of soft tissue is a rare sarcoma with morphologic similarities to malignant melanoma but a distinct genetic background including a chromosomal translocation, t(12;22)(q13;q12), or a resultant EWSR1-ATF1 fusion gene.
  • The tumor cells were either spindle or epithelioid, and they were arranged predominantly in a short fascicular (N=19) or a solid sheetlike growth pattern (N=14).
  • [MeSH-major] Sarcoma, Clear Cell / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD34 / analysis. Antigens, CD57 / analysis. Antigens, Neoplasm / analysis. Calmodulin-Binding Proteins / genetics. Cyclic AMP Response Element-Binding Protein / genetics. Female. Gene Fusion. Genes, bcl-2. Histocytochemistry. Humans. Immunohistochemistry. Keratins / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Microphthalmia-Associated Transcription Factor / analysis. Middle Aged. Mucin-1 / analysis. Neoplasm Metastasis. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local. Proteins / genetics. Proto-Oncogene Proteins c-kit / analysis. Proto-Oncogene Proteins c-met / analysis. RNA-Binding Proteins / genetics. Receptor, ErbB-2 / analysis. S100 Proteins / analysis. Survival Rate. Synaptophysin / analysis. Translocation, Genetic

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  • (PMID = 18300804.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antigens, CD57; 0 / Antigens, Neoplasm; 0 / CREB1 protein, human; 0 / Calmodulin-Binding Proteins; 0 / Cyclic AMP Response Element-Binding Protein; 0 / EWSR1 protein, human; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / Proteins; 0 / RNA-Binding Proteins; 0 / S100 Proteins; 0 / Synaptophysin; 68238-35-7 / Keratins; EC 2.3.1.84 / alcohol O-acetyltransferase; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, ErbB-2
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88. Al-Daraji WI, Makhlouf HR, Miettinen M, Montgomery EA, Goodman ZD, Marwaha JS, Fanburg-Smith JC: Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. Am J Surg Pathol; 2009 Jun;33(6):826-34
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  • [Title] Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma.
  • BACKGROUND: Primary gallbladder sarcoma (PGBS) is rare, with only 39 documented cases, with the predominant type being leiomyosarcoma.
  • DESIGN: Cases recorded as "gallbladder sarcoma" were retrieved from our files; the clinicopathologic features were reviewed and recorded.
  • Epithelial tumors, mixed tumors (carcinosarcoma or sarcomatoid carcinoma), tumors extending into the gallbladder from the abdomen, or sarcoma with other known primaries were excluded.
  • RESULT: PGBS occurred in 4 males and 11 females with the adult median age of 68.5 (range: 24 to 88 y, n=12) and 3 children ages 1.5 to 3 years, the latter all with botryoid embryonal rhabdomyosarcoma.
  • PGBSs were diagnosed as 7 myxofibrosarcomas [malignant fibrous histiocytoma, storiform pleomorphic to myxoid, 2 with an unusual fibromyxoid sarcoma-like (Evans-like), and pleomorphic hyalinizing angiectatic tumor-like mixture], 2 leiomyosarcomas, 1 gastrointestinal stromal tumor-like (GIST-like), 3 botryoid embryonal rhabdomyosarcomas (RMS), and 2 epithelioid angiosarcomas.
  • The GIST-like sarcoma was palisaded and myoid-like but failed to stain for CD34 or CD117.
  • Angiosarcomas demonstrated an extravascular proliferation of atypical epithelioid endothelial cells, and mitotic activity.
  • A variety of sarcoma types are found, yet malignant fibrous histiocytoma is the predominant variant, more common than LMS.
  • GIST is a controversial sarcoma in gallbladder; angiosarcoma can rarely occur in this location.
  • [MeSH-major] Gallbladder Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Prognosis

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  • (PMID = 19194282.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Thomas DG, Giordano TJ, Sanders D, Biermann S, Sondak VK, Trent JC, Yu D, Pollock RE, Baker L: Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma. Cancer; 2005 Feb 15;103(4):830-8
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  • [Title] Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma.
  • BACKGROUND: Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology.
  • METHODS: Archival specimens of synovial sarcoma (n=38) representing 30 patients were assessed for EGFR and HER-2/neu protein expression by standard immunohistochemical techniques.
  • [MeSH-major] Oncogene Proteins, Fusion / genetics. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis. Sarcoma, Synovial / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Gene Amplification. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. RNA, Messenger / analysis. Receptor Protein-Tyrosine Kinases / genetics. Receptor Protein-Tyrosine Kinases / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 15641030.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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90. ten Heuvel SE, Hoekstra HJ, Bastiaannet E, Suurmeijer AJ: The classic prognostic factors tumor stage, tumor size, and tumor grade are the strongest predictors of outcome in synovial sarcoma: no role for SSX fusion type or ezrin expression. Appl Immunohistochem Mol Morphol; 2009 May;17(3):189-95
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  • [Title] The classic prognostic factors tumor stage, tumor size, and tumor grade are the strongest predictors of outcome in synovial sarcoma: no role for SSX fusion type or ezrin expression.
  • BACKGROUND: The aim of this study was to investigate prognostic factors influencing the survival of synovial sarcoma, including the debated role of SYT-SSX fusion type and the newly suggested immunohistochemical marker ezrin.
  • PATIENTS AND METHODS: From 1984 to 2005, 45 patients-25 men (56%) and 20 women (44%) with a median age of 31 (range: 2 to 81) years-were diagnosed with a synovial sarcoma.
  • Ezrin showed high expression in glandular and nonglandular epithelioid components in biphasic synovial sarcoma.
  • Variable expression was found in the mesenchymal component of monophasic and biphasic synovial sarcoma.
  • Low versus high ezrin expression levels in monophasic and/or biphasic synovial sarcoma did not correlate with patient outcome.
  • CONCLUSIONS: Disease stage at presentation, tumor size, and tumor grade were significant predictors of survival in synovial sarcoma.

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  • (PMID = 18997619.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein; 0 / ezrin
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91. Padilla-Rodríguez AL, Bembassat M, Lazaro M, Ortiz-Hidalgo C: Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. Appl Immunohistochem Mol Morphol; 2007 Sep;15(3):346-52
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  • [Title] Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis.
  • Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor arising most frequently in lymph nodes with only few reports of extranodal locations.
  • Histologically the tumor was composed of highly pleomorphic cells exhibiting some uncommon features such as an epithelioid appearance, cystic spaces, and multinucleated cells with morphologic features of emperipolesis.

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  • (PMID = 17721283.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Complement 3b; 0 / Receptors, Complement 3d; 0 / Receptors, IgE
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92. Friedrichs N, Testi MA, Moiraghi L, Modena P, Paggen E, Plötner A, Wiechmann V, Mantovani-Löffler L, Merkelbach-Bruse S, Buettner R, Wardelmann E: Clear cell sarcoma-like tumor with osteoclast-like giant cells in the small bowel: further evidence for a new tumor entity. Int J Surg Pathol; 2005 Oct;13(4):313-8
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  • [Title] Clear cell sarcoma-like tumor with osteoclast-like giant cells in the small bowel: further evidence for a new tumor entity.
  • Here, we report a case of a 41-year-old man with a tumor of the small bowel composed of large epithelioid tumor cells arranged in solid and alveolar sheets including scattered osteoclast-like multinucleated giant cells.
  • The diagnosis was established by 2 different FISH strategies demostrating the presence of a t(12;22)(q13;q12) translocation, the diagnostic hallmark of clear cell sarcoma of soft parts.
  • Our results provide further evidence for the existence of a new tumor entity designated gastrointestinal clear cell sarcoma with osteoclast-like giant cells.
  • [MeSH-major] Jejunal Neoplasms / diagnosis. Osteoclasts / pathology. Sarcoma, Clear Cell / diagnosis
  • [MeSH-minor] Adult. Antigens, Neoplasm. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 22. Diagnosis, Differential. Giant Cells / pathology. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. Phosphopyruvate Hydratase / analysis. Receptor, Nerve Growth Factor / analysis. S100 Proteins / analysis. Translocation, Genetic. Vimentin / analysis

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  • [CommentIn] Int J Surg Pathol. 2005 Oct;13(4):309-11 [16273185.001]
  • (PMID = 16273186.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Receptor, Nerve Growth Factor; 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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93. Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Kawai A, Sonobe H, Takahira T, Kobayashi C, Yamamoto H, Tamiya S, Hirohashi S, Iwamoto Y, Tsuneyoshi M: Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression. Am J Surg Pathol; 2007 Jan;31(1):85-94
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  • [Title] Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression.
  • Synovial sarcoma is a very rare mesenchymal tumor that exhibits an epithelial profile.
  • To confirm the diagnosis of synovial sarcoma, we evaluated several immunohistochemical markers, or detected SYT-SSX fusion gene transcript.
  • We studied the clinicopathologic features in 92 synovial sarcoma patients and also assessed the immunohistochemical expression of dysadherin and E-cadherin to examine their possible association with histologic subtype and biologic behavior.
  • Synovial sarcoma patients with dysadherin expression survived for a significantly shorter time than those without dysadherin expression (P=0.0006).
  • We conclude that E-cadherin dysfunction by dysadherin is associated with reduced E-cadherin expression and morphologic change from epithelioid to spindle phenotype.
  • Dysadherin expression is considered to be one of the determinants of histologic subtype in synovial sarcoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cadherins / metabolism. Membrane Glycoproteins / metabolism. Neoplasm Proteins / metabolism. Sarcoma, Synovial / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Disease Progression. Extremities. Female. Gene Expression. Humans. Immunoenzyme Techniques. Male. Mitotic Index. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Prognosis. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Survival Rate

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  • (PMID = 17197923.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / FXYD5 protein, human; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / SYT-SSX fusion protein
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94. Hammock L, Reisenauer A, Wang W, Cohen C, Birdsong G, Folpe AL: Latency-associated nuclear antigen expression and human herpesvirus-8 polymerase chain reaction in the evaluation of Kaposi sarcoma and other vascular tumors in HIV-positive patients. Mod Pathol; 2005 Apr;18(4):463-8
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  • [Title] Latency-associated nuclear antigen expression and human herpesvirus-8 polymerase chain reaction in the evaluation of Kaposi sarcoma and other vascular tumors in HIV-positive patients.
  • Human herpesvirus-8 (HHV-8) latency-associated nuclear antigen (LANA) is expressed in endothelial and spindle cells of nearly all Kaposi sarcomas, and the presence of this antigen in serum is strongly correlated with the risk of developing Kaposi sarcoma in immunocompromised individuals.
  • Studies of vascular tumors occurring in the general population show LANA expression to be specific for Kaposi sarcoma.
  • No study to date, however, has examined whether non-Kaposi sarcoma vascular tumors arising in immunocompromised patients may express LANA, possibly reflecting origin from an HHV-8-infected endothelial progenitor cell.
  • The objective of this study was to evaluate the specificity of LANA expression for Kaposi sarcoma in immunocompromised patients by LANA immunohistochemistry and real-time polymerase chain reaction (PCR) for HHV-8.
  • A total of 13 cases of non-Kaposi sarcoma vascular tumors (12 hemangiomas and one epithelioid hemangioendothelioma) and 24 cases of Kaposi sarcoma, all from known HIV-positive patients, were immunostained for LANA and evaluated for the presence of HHV-8 DNA by real-time PCR.
  • LANA expression was seen in 22 of 24 (92%) of Kaposi sarcoma cases and in 0 of 13 non-Kaposi sarcoma cases.
  • Real-time PCR detected HHV-8 in all of the Kaposi sarcoma cases and in four of the non-Kaposi sarcoma cases (all hemangiomas).
  • LANA expression appears to be a highly sensitive and specific marker of Kaposi sarcoma in both the general population and in HIV-positive patients.
  • This is in contrast to HHV-8 PCR, which is positive in a small subset of non-Kaposi sarcoma vascular tumors, most likely due to detection of HHV-8 within intratumoral blood mononuclear cells by the highly sensitive real-time PCR technique.
  • [MeSH-major] HIV Infections / complications. Hemangioma / diagnosis. Herpesvirus 8, Human / genetics. Nuclear Proteins / biosynthesis. Sarcoma, Kaposi / diagnosis
  • [MeSH-minor] Adult. Antigens, Viral. DNA, Viral / genetics. Female. HIV Seropositivity. Hemangioendothelioma / complications. Hemangioendothelioma / diagnosis. Hemangioendothelioma / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction / methods


95. Pennacchioli E, Deraco M, Mariani L, Fiore M, Mussi C, Collini P, Olmi P, Casali PG, Santinami M, Gronchi A: Advanced extremity soft tissue sarcoma: prognostic effect of isolated limb perfusion in a series of 88 patients treated at a single institution. Ann Surg Oncol; 2007 Feb;14(2):553-9
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  • [Title] Advanced extremity soft tissue sarcoma: prognostic effect of isolated limb perfusion in a series of 88 patients treated at a single institution.
  • Patients with in-transit metastases (epithelioid sarcomas and clear cell sarcomas) had a significantly worse long-term outcome (LDFS at 5 years was 40.9 vs 67.3%, P < 0.05).
  • It should therefore be considered as a valid option for patients affected by limb-threatening STS, save for in-transit metastases from epithelioid and clear cell sarcoma.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Chemotherapy, Cancer, Regional Perfusion. Neoplasm, Residual / surgery. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Amputation. Doxorubicin / administration & dosage. Female. Humans. Male. Melphalan / administration & dosage. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 17122991.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; Q41OR9510P / Melphalan
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96. Gaumann A, Bode-Lesniewska B, Zimmermann DR, Fanburg-Smith JC, Kirkpatrick CJ, Hofstädter F, Woenckhaus M, Stoehr R, Obermann EC, Dietmaier W, Hartmann A: Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases. Virchows Arch; 2008 Nov;453(5):473-84
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  • [Title] Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases.
  • Pulmonary artery sarcoma (PAS) were studied by morphologic, immunohistochemical, and molecular genetic methods of the Wnt pathway.
  • PAS were classified as epithelioid (n = 4) or malignant fibrous histiocytoma (MFH; spindled/pleomorphic, n = 4), myxofibrosarcoma (n = 8), and one each hemangiopericytoma-like or malignant inflammatory myofibroblastic tumor-like.
  • Alteration in chromosome 5q21 (APC) was found in 4/14 PAS by LOH, mostly epithelioid-type; an MFH-type case demonstrated microsatellite instability (MSI) and nuclear beta-catenin.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Pulmonary Artery / pathology. Sarcoma / classification. Signal Transduction / physiology. Tunica Intima / pathology. Vascular Neoplasms / classification. beta Catenin / metabolism
  • [MeSH-minor] Adult. Aged. Cyclin A / metabolism. Cyclin D1 / metabolism. Female. Humans. Loss of Heterozygosity / genetics. Male. Middle Aged. Retrospective Studies. Sequence Analysis, DNA

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  • (PMID = 18807072.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Cyclin A; 0 / beta Catenin; 136601-57-5 / Cyclin D1
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97. Bahrami A, Folpe AL: Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am J Surg Pathol; 2010 Oct;34(10):1504-13
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  • [Title] Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period.
  • Adult-type fibrosarcoma (FS) was once considered the most common adult sarcoma, but is now considered a diagnosis of exclusion.
  • One hundred ninety-five cases diagnosed as adult FS in somatic soft tissue were retrieved from our institutional archives for the period 1960 to 2008.
  • Non-FS (137 cases) were reclassified as: undifferentiated pleomorphic sarcoma (32 cases), SS (21 cases), solitary fibrous tumor (14 cases), myxofibrosarcoma (11 cases), malignant peripheral nerve sheath tumor (8 cases), FS dermatofibrosarcoma protuberans, and desmoplastic melanoma (4 cases each), low-grade fibromyxoid sarcoma, sarcomatoid carcinoma, desmoid-type fibromatosis, rhabdomyosarcoma, myofibroblastic sarcoma, spindle-cell liposarcoma (3 cases each), sclerosing epithelioid FS, fibroma-like epithelioid sarcoma, leiomyosarcoma, cellular fibrous histiocytoma (2 cases each), and others (17 cases).
  • Exclusive of undifferentiated pleomorphic sarcoma, the distinction of which from FS is subjective, 64% of putative FS were reclassified, most commonly as monophasic SS and solitary fibrous tumor.
  • We conclude that true FS is exceedingly rare, accounting for <1% of approximately 10,000 adult soft tissue sarcomas seen at our institution during this time period, and should be diagnosed with great caution.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Minnesota / epidemiology. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Repressor Proteins / genetics. Repressor Proteins / metabolism. Young Adult

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  • (PMID = 20829680.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; 0 / SS18 protein, human
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98. Bien E, Kazanowska B, Dantonello T, Adamkiewicz-Drozynska E, Balcerska A, Madziara W, Rybczynska A, Nurzynska-Flak J, Solarz E, Kurylak A, Zalewska-Szewczyk B, Krawczyk M, Izycka-Swieszewska E, Rapala M, Koscielniak E: Factors predicting survival in childhood malignant and intermediate vascular tumors : retrospective analysis of the Polish and German cooperative paediatric soft tissue sarcoma study groups and review of the literature. Ann Surg Oncol; 2010 Jul;17(7):1878-89
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  • [Title] Factors predicting survival in childhood malignant and intermediate vascular tumors : retrospective analysis of the Polish and German cooperative paediatric soft tissue sarcoma study groups and review of the literature.
  • METHODS: A total of 32 children with malignant vascular tumors (14 angiosarcomas [AS], 5 epithelioid hemangioendotheliomas, and 13 intermediate vascular tumors, including other hemangioendotheliomas plus adult-type hemangiopericytomas), registered in the German and Polish Paediatric Soft Tissue Sarcomas Study Groups, were treated following the Cooperative Weichteilsarkom Studiengruppe (CWS)-81, -86, -91, and -96 protocols.
  • CONCLUSIONS: The clinical course and outcome in childhood epithelioid HE seems to be similar to intravascular tumors and less aggressive than AS.
  • [MeSH-major] Hemangioendothelioma / mortality. Hemangiopericytoma / mortality. Hemangiosarcoma / mortality. Sarcoma / mortality. Vascular Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Germany / epidemiology. Humans. Infant. Infant, Newborn. Male. Poland / epidemiology. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 20333551.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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99. Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, La Quaglia MP, Fong Y, Brennan MF, Blumgart LH, Dematteo RP: Management of primary liver sarcomas. Cancer; 2007 Apr 1;109(7):1391-6
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  • BACKGROUND: Primary hepatic sarcoma is a rare entity.
  • METHODS: Between January 1981 and December 2004, 30 patients with primary sarcoma of the liver and 5 patients with primary carcinosarcoma of the liver were treated.
  • RESULTS: Of the 30 patients with primary hepatic sarcoma (10 epithelioid hemangioendothelioma, 5 embryonal sarcoma, 5 angiosarcoma, 3 solitary fibrous tumor, and 7 other types), 11 underwent R0-resection and had a 5-year disease-specific survival of 64%.
  • Of these 11 patients, 4 had low-grade sarcoma and have not developed tumor recurrence.
  • In the group of 7 patients with high-grade sarcomas who underwent R0-resection, both patients with angiosarcoma died within 11 months, whereas the 5 patients with embryonal sarcoma had a 5-year disease-free and disease-specific survival of 80%.
  • Six of the 10 patients with an epithelioid hemangioendothelioma were managed without surgery, as they had diffuse, slowly progressing, or stable lesions; these patients had a 5-year disease-specific survival of 67%.
  • CONCLUSIONS: The outcome of patients with primary hepatic sarcoma depends primarily on tumor histology and the ability to achieve complete tumor resection.
  • [MeSH-major] Liver Neoplasms / therapy. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinosarcoma / therapy. Child. Female. Fibrosarcoma / therapy. Hemangioendothelioma, Epithelioid / therapy. Hemangiosarcoma / therapy. Humans. Leiomyosarcoma / therapy. Male. Middle Aged. Prognosis. Prospective Studies. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17315167.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Liu Y, Zheng H, Liu Y, Fang K: Metastatic epithelioid sarcoma. Eur J Dermatol; 2007 May-Jun;17(3):249-50
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  • [Title] Metastatic epithelioid sarcoma.
  • [MeSH-major] Lung Neoplasms / secondary. Sarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Ankle / pathology. Epithelioid Cells / pathology. Female. Humans. Skin Ulcer / etiology

  • Genetic Alliance. consumer health - Epithelioid Sarcoma.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
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  • (PMID = 17478394.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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