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1. Barnoud R, Collardeau-Frachon S, de la Roche E, Vasiljevic A, Thomson V, Ranchère D, Devouassoux G, Devouassoux-Shisheboran M: [Lung metastases of epithelioid sarcoma revealed by bilateral spontaneous pneumothorax: a pathological diagnosis]. Ann Pathol; 2010 Apr;30(2):139-42
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  • [Title] [Lung metastases of epithelioid sarcoma revealed by bilateral spontaneous pneumothorax: a pathological diagnosis].
  • Spontaneous pneumothorax may be one of the presenting manifestation of metastatic epithelioid sarcoma even if imaging does not show evident metastatic nodules.
  • We report the case of a 24-year-old man presenting a bilateral spontaneous pneumothorax in association with an epithelioid sarcoma developed in the right foot.
  • Histopathological examination of the pulmonary biopsies revealed rare millimetric nodules, composed of very atypical epithelioid cells, growing along alveolar walls reminiscent of a bronchiolo-alveolar carcinoma.
  • All these constatations allowed a diagnosis of pulmonary metastases of the epithelioid sarcoma.
  • [MeSH-major] Foot Diseases / pathology. Lung Neoplasms / secondary. Pneumothorax / etiology. Sarcoma / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Doxorubicin / administration & dosage. Drainage. Fatal Outcome. Humans. Ifosfamide / administration & dosage. Male. Neoplasm Proteins / analysis. Pleurodesis. Thoracoscopy. Thoracotomy. Young Adult


2. Fisher C: Epithelioid sarcoma of Enzinger. Adv Anat Pathol; 2006 May;13(3):114-21
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  • [Title] Epithelioid sarcoma of Enzinger.
  • Epithelioid sarcoma was named in 1970 in a classic paper by Enzinger, who expanded the observations in a larger series in 1985.
  • He defined a sarcoma with a peak incidence in young adult males and a predilection for extremities, involving subcutis or deeper tissue and extending along tendon sheaths or aponeuroses.
  • Epithelioid sarcomas regularly express vimentin, cytokeratins, and epithelial membrane antigen, and about half are positive for CD34, but a wide range of other antigens can be expressed.
  • The tumor has no normal cellular counterpart and differs from both synovial sarcoma and carcinoma.
  • There is a wide differential diagnosis from numerous benign and malignant conditions, including granuloma annulare, melanoma, and epithelioid vascular neoplasms.
  • Epithelioid sarcoma has a high recurrence rate, which can be reduced by adequate surgery, and up to 40% metastasize, to regional lymph nodes, to lung, and other locations including scalp.
  • Thirty-six years after Enzinger's original account, epithelioid sarcoma remains a clinically and pathologically distinct, indolent but aggressive sarcoma of indeterminate lineage.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epithelioid Cells / pathology. Female. History, 20th Century. Humans. Male

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  • (PMID = 16778474.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 58
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3. Loya AC, Prayaga AK, Arora A, Sundaram C, Rao IS, Uppin SG, Raju GS, Surath A, Rajappa RS: Lymph node metastasis of soft tissue tumors: a cytomorphologic study. Acta Cytol; 2007 Mar-Apr;51(2):153-60
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  • STTs commonly involving lymph nodes were rhabdomyosarcoma and extraskeletal Ewing's/primitive neuroectodermal tumor (PNET); other rare tumors included malignant granular cell tumor, epithelioid hemangioendothelioma, mediastinal ganglioneuroblastoma, angiosarcoma and epithelioid sarcoma.
  • [MeSH-major] Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Rhabdomyosarcoma / secondary. Sarcoma, Ewing / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle / standards. Biopsy, Fine-Needle / statistics & numerical data. Biopsy, Fine-Needle / trends. Child. Child, Preschool. Diagnosis, Differential. Diagnostic Errors / prevention & control. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prevalence. Prognosis. Prospective Studies. Retrospective Studies

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  • (PMID = 17425195.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Tu XY, Sheng WQ, Lu HF, Wang J: [Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Oct;36(10):660-5
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  • [Title] [Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma].
  • OBJECTIVE: To study the clinicopathologic features and immunophenotype of intraabdominal extranodal follicular dendritic cell sarcoma (FDCS) and the relationship with Epstein-Barr virus (EBV).
  • Histologically, there were plump spindle, ovoid to epithelioid cells associated with scattered multinucleated giant cells.
  • [MeSH-major] Abdominal Neoplasms / pathology. Dendritic Cell Sarcoma, Follicular / pathology. Epstein-Barr Virus Infections. Receptors, Complement 3d / metabolism. Receptors, IgE / metabolism
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Gastrointestinal Stromal Tumors / pathology. Granuloma, Plasma Cell / pathology. Humans. Immunophenotyping. Male. Middle Aged. Vimentin / metabolism

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  • (PMID = 18194598.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Receptors, Complement 3d; 0 / Receptors, IgE; 0 / Vimentin
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5. Gürkan V, Ozger H: [Sarcomas of the hand]. Acta Orthop Traumatol Turc; 2007 Aug-Oct;41(4):286-90
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  • We evaluated patients who underwent surgical treatment for sarcoma of the hand.
  • METHODS: Between 1990 and 2006, eight patients (5 males, 3 females; mean age 39.6 years; range 26 to 67 years) with hand sarcoma received treatment at two centers.
  • RESULTS: Mortality occurred in two patients due to multiple metastases, who had synovial sarcoma in the carpal region and clear cell sarcoma in the wrist, respectively.
  • Apart from clear cell sarcoma, diagnoses of other wrist tumors were stage IIB epithelioid sarcoma and malignant fibrous histiocytoma.
  • [MeSH-major] Hand. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Severity of Illness Index. Treatment Outcome. Turkey / epidemiology

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  • (PMID = 18180558.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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6. Ikeda K, Tate G, Suzuki T, Mitsuya T: Fine needle aspiration cytology of primary proximal-type epithelioid sarcoma of the perineum: a case report. Acta Cytol; 2005 May-Jun;49(3):314-8
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  • [Title] Fine needle aspiration cytology of primary proximal-type epithelioid sarcoma of the perineum: a case report.
  • BACKGROUND: Epithelioid sarcoma is a malignant soft tissue tumor of unknown histogenesis.
  • We describe the cytologic findings in a case of primary proximal-type epithelioid sarcoma of the perineum and results of an immunofluorescence analysis of rhabdoid cells from this tumor.
  • To the best of our knowledge, the 3-color immunofluorescence features of proximal-type epithelioid sarcoma have never before been reported.
  • After excision of the tumor, histopathologic examination of the resected specimen suggested a diagnosis of proximal-type epithelioid sarcoma.
  • The cytoplasmic staining pattern differed between rhabdoid and epithelioid sarcoma cells.
  • CONCLUSION: Immunofluorescent staining of rhabdoid cells from a primary perineal proximal-type epithelioid sarcoma revealed an uneven distribution of cytokeratin in intracytoplasmic inclusions, with the highest concentration at the periphery of the inclusions.
  • [MeSH-major] Perineum. Sarcoma / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Immunohistochemistry. Male

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  • (PMID = 15966295.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Zevallos-Giampietri EA, Barrionuevo C: Proximal-type epithelioid sarcoma: report of two cases in the perineum: differential diagnosis and review of soft tissue tumors with epithelioid and/or rhabdoid features. Appl Immunohistochem Mol Morphol; 2005 Sep;13(3):221-30
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  • [Title] Proximal-type epithelioid sarcoma: report of two cases in the perineum: differential diagnosis and review of soft tissue tumors with epithelioid and/or rhabdoid features.
  • The authors report two cases of perineal proximal-type epithelioid sarcoma in middle-aged men, age 51 and 43 years old.
  • Since proximal-type epithelioid sarcoma can be confused with a number of other soft tissue tumors with epithelioid and/or rhabdoid features, the authors emphasize the immunohistochemical differential diagnosis.


8. Wang CN, An XJ, Shi QL, Xu Y, Zhou XJ, Li NY, Zhou HB, Ma HH: [Clinicopathological study of 5 cases of proximal-type epithelioid sarcoma]. Zhonghua Bing Li Xue Za Zhi; 2009 May;38(5):298-301
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  • [Title] [Clinicopathological study of 5 cases of proximal-type epithelioid sarcoma].
  • OBJECTIVE: To investigate the clinicopathological characteristics, diagnosis and differential diagnoses of proximal-type epithelioid sarcoma (PES).
  • The tumors consisted of relatively uniform epithelioid cells with round or oval nuclei and eosinophilic cytoplasm.
  • [MeSH-major] Pelvic Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Vimentin / metabolism. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mucin-1 / metabolism. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Young Adult. beta Catenin / metabolism


9. Huang SC, Chang CL, Huang CH, Chang CC: Histiocytic sarcoma - a case with evenly distributed multinucleated giant cells. Pathol Res Pract; 2007;203(9):683-9
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  • [Title] Histiocytic sarcoma - a case with evenly distributed multinucleated giant cells.
  • Histiocytic sarcoma is an uncommon neoplasm of mature histiocytes with a poor clinical outcome.
  • We report a case of a true histiocytic sarcoma with prominent and evenly distributed multinucleated giant cells that mimics a giant cell tumor of soft tissue.
  • Microscopically, polygonal mononuclear tumor cells aggregated to form somewhat epithelioid nests, which occasionally showed coagulative necrosis.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Giant Cells / pathology. Histiocytes / pathology. Histiocytic Disorders, Malignant / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Adult. Antigens, CD / analysis. Cell Lineage. Diagnosis, Differential. Female. Humans. Muramidase / analysis. Neoplasm Invasiveness. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17673373.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; EC 3.2.1.17 / Muramidase
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10. Magro G, Emmanuele C, Lopes M, Vallone G, Greco P: Solitary fibrous tumour of the kidney with sarcomatous overgrowth. Case report and review of the literature. APMIS; 2008 Nov;116(11):1020-5
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  • This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34+ mitotically active atypical plump spindle- to epithelioid-shaped cells, including pleomorphic multinucleated giant cells.
  • [MeSH-major] Kidney / pathology. Kidney Neoplasms / pathology. Sarcoma / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Prognosis. S100 Proteins / metabolism

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  • (PMID = 19133003.001).
  • [ISSN] 1600-0463
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 36
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11. Miettinen M, Fetsch JF: Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol; 2006 Apr;30(4):521-8
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  • [Title] Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases.
  • In this study, we analyzed a uniform group of 44 lesions composed of epithelioid histiocytes, comprising a subset of lesions originally designated as reticulohistiocytoma, and propose designating them as "solitary epithelioid histiocytoma" (SEH), in line with the recently published classification proposal for histiocytic disorders.
  • They were composed of large epithelioid histiocytes with a varying number of lymphocytes and neutrophils.
  • Immunohistochemically, the epithelioid histiocytes were positive for CD163, CD68, lysozyme (variably), and vimentin.
  • The epithelioid histiocytes were consistently negative for CD3, CD20, CD30, HMB45, and keratins.
  • It needs to be distinguished from Rosai-Dorfman disease, juvenile xanthogranuloma, a variety of granulomatous conditions, and some malignant neoplasms, including histiocytic sarcoma, melanoma, and epithelioid sarcoma.
  • [MeSH-major] Epithelioid Cells / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytosis, Sinus / diagnosis. Humans. Male. Middle Aged. Sarcoma / diagnosis. Sex Distribution. Xanthogranuloma, Juvenile / diagnosis

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  • (PMID = 16625100.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. Hisaoka M, Ishida T, Kuo TT, Matsuyama A, Imamura T, Nishida K, Kuroda H, Inayama Y, Oshiro H, Kobayashi H, Nakajima T, Fukuda T, Ae K, Hashimoto H: Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases. Am J Surg Pathol; 2008 Mar;32(3):452-60
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  • [Title] Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases.
  • Clear cell sarcoma (CCS) of soft tissue is a rare sarcoma with morphologic similarities to malignant melanoma but a distinct genetic background including a chromosomal translocation, t(12;22)(q13;q12), or a resultant EWSR1-ATF1 fusion gene.
  • The tumor cells were either spindle or epithelioid, and they were arranged predominantly in a short fascicular (N=19) or a solid sheetlike growth pattern (N=14).
  • [MeSH-major] Sarcoma, Clear Cell / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD34 / analysis. Antigens, CD57 / analysis. Antigens, Neoplasm / analysis. Calmodulin-Binding Proteins / genetics. Cyclic AMP Response Element-Binding Protein / genetics. Female. Gene Fusion. Genes, bcl-2. Histocytochemistry. Humans. Immunohistochemistry. Keratins / analysis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Microphthalmia-Associated Transcription Factor / analysis. Middle Aged. Mucin-1 / analysis. Neoplasm Metastasis. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local. Proteins / genetics. Proto-Oncogene Proteins c-kit / analysis. Proto-Oncogene Proteins c-met / analysis. RNA-Binding Proteins / genetics. Receptor, ErbB-2 / analysis. S100 Proteins / analysis. Survival Rate. Synaptophysin / analysis. Translocation, Genetic

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  • (PMID = 18300804.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antigens, CD57; 0 / Antigens, Neoplasm; 0 / CREB1 protein, human; 0 / Calmodulin-Binding Proteins; 0 / Cyclic AMP Response Element-Binding Protein; 0 / EWSR1 protein, human; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / Proteins; 0 / RNA-Binding Proteins; 0 / S100 Proteins; 0 / Synaptophysin; 68238-35-7 / Keratins; EC 2.3.1.84 / alcohol O-acetyltransferase; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, ErbB-2
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13. Zhao H, Cai JQ, Bi XY, Zhao JJ, Huang Z, Lu HZ, Zhou HT: [Diagnosis,treatment, and prognostic of liver sarcoma: analysis of 16 cases]. Zhonghua Yi Xue Za Zhi; 2008 Jun 10;88(22):1537-9
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  • [Title] [Diagnosis,treatment, and prognostic of liver sarcoma: analysis of 16 cases].
  • OBJECTIVE: To explore the diagnosis, treatment, and prognostic factors of liver sarcoma.
  • METHODS: The clinical data of 16 liver sarcoma patients, 9 males and 7 females, aged 46.7 (12-73), treated 1980-2005, were analyzed retrospectively.
  • Pathological analysis diagnosed 6 patients (37.5%) as with leiomyosarcoma, 5 patients (31.25%) with angiosarcoma, 2 patients (12.5%) with fibrosarcoma, 1 patient (12.5%) with epithelioid hemangioendothelioma, 1 patient (12.5%) with myxoid liposarcoma, and 1 patient (12.5%) with undifferentiated embryonal sarcoma.
  • CONCLUSION: Liver sarcoma is difficult to be diagnosed preoperatively.
  • Surgical resection is the mainstay of the treatment of liver sarcoma.
  • [MeSH-major] Liver Neoplasms / diagnosis. Liver Neoplasms / surgery. Sarcoma / diagnosis. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Prognosis. Survival Analysis. Young Adult

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  • (PMID = 18956634.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Klebe S, Mahar A, Henderson DW, Roggli VL: Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review. Mod Pathol; 2008 Sep;21(9):1084-94
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  • Of the 27 mesothelioma cases 16 (59%) were sarcomatoid, 10 (37%) were biphasic, and one was reported as epithelioid; 40% (11 cases) showed osteosarcomatous elements only, 19% showed areas of rhabdomyosarcoma only, 19% contained areas of chondrosarcoma only, and 22% exhibited osteochondromatous elements.
  • [MeSH-major] Mesothelioma / pathology. Peritoneal Neoplasms / pathology. Pleural Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Chondrosarcoma / metabolism. Chondrosarcoma / mortality. Chondrosarcoma / pathology. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Keratins / metabolism. Male. Middle Aged. Osteosarcoma / metabolism. Osteosarcoma / mortality. Osteosarcoma / pathology. Rhabdomyosarcoma / metabolism. Rhabdomyosarcoma / mortality. Rhabdomyosarcoma / pathology. Survival Rate


15. Mosquera JM, Fletcher CD: Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT? Am J Surg Pathol; 2009 Sep;33(9):1314-21
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  • Dedifferentiation is a well recognized, if sometimes controversial, form of tumor progression in certain types of soft tissue and bone sarcoma, and confers a worse prognosis when compared with the low-grade counterpart.
  • In addition to typical features of benign-appearing SFT there was an abrupt transition to nondistinctive high-grade sarcoma in all cases.
  • The latter included epithelioid, round cell, and/or spindle cell components with increased mitotic activity, necrosis, and cystic degeneration.
  • [MeSH-minor] Adult. Aged. Anaplasia / genetics. Anaplasia / pathology. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Chromosome Aberrations. Comparative Genomic Hybridization. DNA, Neoplasm / analysis. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Sarcoma / genetics. Sarcoma / metabolism. Sarcoma / secondary. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19718788.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / Tumor Suppressor Protein p53
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16. Bahrami A, Folpe AL: Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am J Surg Pathol; 2010 Oct;34(10):1504-13
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  • [Title] Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period.
  • Adult-type fibrosarcoma (FS) was once considered the most common adult sarcoma, but is now considered a diagnosis of exclusion.
  • One hundred ninety-five cases diagnosed as adult FS in somatic soft tissue were retrieved from our institutional archives for the period 1960 to 2008.
  • Non-FS (137 cases) were reclassified as: undifferentiated pleomorphic sarcoma (32 cases), SS (21 cases), solitary fibrous tumor (14 cases), myxofibrosarcoma (11 cases), malignant peripheral nerve sheath tumor (8 cases), FS dermatofibrosarcoma protuberans, and desmoplastic melanoma (4 cases each), low-grade fibromyxoid sarcoma, sarcomatoid carcinoma, desmoid-type fibromatosis, rhabdomyosarcoma, myofibroblastic sarcoma, spindle-cell liposarcoma (3 cases each), sclerosing epithelioid FS, fibroma-like epithelioid sarcoma, leiomyosarcoma, cellular fibrous histiocytoma (2 cases each), and others (17 cases).
  • Exclusive of undifferentiated pleomorphic sarcoma, the distinction of which from FS is subjective, 64% of putative FS were reclassified, most commonly as monophasic SS and solitary fibrous tumor.
  • We conclude that true FS is exceedingly rare, accounting for <1% of approximately 10,000 adult soft tissue sarcomas seen at our institution during this time period, and should be diagnosed with great caution.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Minnesota / epidemiology. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Repressor Proteins / genetics. Repressor Proteins / metabolism. Young Adult


17. Daigeler A, Kuhnen C, Moritz R, Stricker I, Goertz O, Tilkorn D, Steinstraesser L, Steinau HU, Lehnhardt M: Lymph node metastases in soft tissue sarcomas: a single center analysis of 1,597 patients. Langenbecks Arch Surg; 2009 Mar;394(2):321-9
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  • PURPOSE: The aim of this study was to examine the clinical course of patients with the rare finding of regional lymph node metastasis (RLNM) from soft tissue sarcoma.
  • MATERIALS AND METHODS: Data from 28 out of 1,597 consecutive soft tissue sarcoma patients with RLNM were from the patients' charts and interviewing patients and general practitioners.
  • RESULTS: RLNM was seen in 21.4% for epithelioid sarcoma and 17.6% for clear cell sarcoma.
  • [MeSH-major] Lymphatic Metastasis / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant. Young Adult

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  • (PMID = 18594854.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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18. Kiani B, Ferrell LD, Qualman S, Frankel WL: Immunohistochemical analysis of embryonal sarcoma of the liver. Appl Immunohistochem Mol Morphol; 2006 Jun;14(2):193-7
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  • [Title] Immunohistochemical analysis of embryonal sarcoma of the liver.
  • Embryonal sarcoma of the liver is a rare, aggressive malignant tumor that typically occurs in children and teenagers.
  • Tumors ranged from 10 to 20 cm and contained spindled and epithelioid areas with PAS-positive, diastase-resistant globules and atypical cells with focal multinucleation.
  • The diagnosis of embryonal sarcoma is based on typical morphologic features in a large liver tumor occurring in a young patient.

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  • (PMID = 16785789.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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19. Huang W, Zhang X, Li D, Chen J, Meng K, Wang Y, Lu Z, Zhou X: Osteoclast-rich tumor of the gastrointestinal tract with features resembling those of clear cell sarcoma of soft parts. Virchows Arch; 2006 Feb;448(2):200-3
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  • [Title] Osteoclast-rich tumor of the gastrointestinal tract with features resembling those of clear cell sarcoma of soft parts.
  • Clear cell sarcoma is a high-grade sarcoma with morphological features resembling those of malignant melanoma.
  • The differential diagnosis included gastrointestinal stromal tumor, primary or metastatic melanoma, and epithelioid malignant peripheral nerve sheath tumor.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Osteoclasts / pathology. Sarcoma, Clear Cell / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Diagnosis, Differential. Giant Cells / chemistry. Giant Cells / pathology. Humans. Immunohistochemistry. Male. S100 Proteins / analysis

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  • (PMID = 16220298.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / S100 Proteins
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20. Armah HB, Parwani AV: Epithelioid sarcoma. Arch Pathol Lab Med; 2009 May;133(5):814-9
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  • [Title] Epithelioid sarcoma.
  • Epithelioid sarcomas are rare, mesenchymal tumors of unknown histogenesis and display multidirectional differentiation, which is predominantly epithelial.
  • They have no normal cellular counterpart and differ from both synovial sarcoma and carcinoma.
  • They account for less than 1% of all soft tissue sarcomas and are usually slow growing, with peak incidence in young adult men and occur predominantly in extremities.
  • Clinically, they have a high recurrence rate, and up to 50% of epithelioid sarcomas metastasize.
  • [MeSH-major] Sarcoma / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 19415960.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 30
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21. Peterson MR, Piao Z, Weidner N, Yi ES: Strong PDGFRA positivity is seen in GISTs but not in other intra-abdominal mesenchymal tumors: Immunohistochemical and mutational analyses. Appl Immunohistochem Mol Morphol; 2006 Dec;14(4):390-6
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  • Three of 4 GIST cases with PDGFRA mutations show epithelioid morphology and strong PDGFRA immunoreactivity with prominent perinuclear dotlike accentuation (so-called Golgi pattern).

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  • (PMID = 17122634.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.11.1 / Oncogene Protein v-akt
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22. Shet T, Viswanathan S: The cytological diagnosis of paediatric renal tumours. J Clin Pathol; 2009 Nov;62(11):961-9
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  • An approach based on classifying smears according to their cellular patterns as triphasic, round cell, spindle cell or epithelioid cell type assists in classifying paediatric renal tumours on cytology.
  • [MeSH-minor] Adolescent. Age Distribution. Biopsy, Fine-Needle / methods. Carcinoma, Renal Cell / pathology. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Infant, Newborn. Nephroma, Mesoblastic / pathology. Rhabdoid Tumor / pathology. Sarcoma, Clear Cell / pathology. Sarcoma, Ewing / pathology. Young Adult

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  • (PMID = 19700411.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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23. Thorson JA, Weigelin HC, Ruiz RE, Howard JK, Lucas DR: Identification of SYT-SSX transcripts from synovial sarcomas using RT-multiplex PCR and capillary electrophoresis. Mod Pathol; 2006 May;19(5):641-7
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  • Chimeric transcripts were not detected in 9/9 malignant peripheral nerve sheath tumors or 1/1 epithelioid sarcoma.
  • [MeSH-major] Biomarkers, Tumor / genetics. Electrophoresis, Capillary / methods. Oncogene Proteins, Fusion / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Child. Female. Genotype. Humans. Male. Middle Aged. Molecular Sequence Data. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reproducibility of Results. Sequence Analysis, DNA. Transcription, Genetic / genetics

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  • (PMID = 16547469.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Oncogene Proteins, Fusion; 0 / RNA, Neoplasm; 0 / SYT-SSX fusion protein
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24. Ishiguro N, Motoi T, Araki N, Ito H, Moriyama M, Yoshida H: Expression of cardiac ankyrin repeat protein, CARP, in malignant tumors: diagnostic use of CARP protein immunostaining in rhabdomyosarcoma. Hum Pathol; 2008 Nov;39(11):1673-9
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  • In contrast, focal immunoreactivity for CARP was only observed in 5 (4%) of 125 non-rhabdomyosarcomas, comprising 2 malignant fibrous histiocytomas, 1 angiosarcoma, 1 epithelioid sarcoma, and 1 squamous cell carcinoma of the lung.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology

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  • (PMID = 18656235.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ANKRD1 protein, human; 0 / Biomarkers, Tumor; 0 / Muscle Proteins; 0 / Nuclear Proteins; 0 / Repressor Proteins
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25. Bhargava R, Shia J, Hummer AJ, Thaler HT, Tornos C, Soslow RA: Distinction of endometrial stromal sarcomas from 'hemangiopericytomatous' tumors using a panel of immunohistochemical stains. Mod Pathol; 2005 Jan;18(1):40-7
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  • Staining with antismooth muscle antigen was seen in 11 of 17 cases of endometrial stromal sarcoma, with more intense staining seen in areas showing smooth muscle differentiation.
  • Staining with AE1/3 was seen in four of 17 endometrial stromal sarcomas, with two of the positive cases containing epithelioid cells.
  • CD34 expression was identified in six of eight hemangiopericytomas and 13 of 14 solitary fibrous tumors, but we did not find expression of CD34 in synovial sarcoma.
  • Differences between endometrial stromal sarcoma and other soft-tissue tumors were detected for all of the immunohistochemical markers (P<0.05), except anti-bcl-2 and AE1/3.
  • Antibodies against CD10 mark a substantial number of hemangiopericytomas and solitary fibrous tumors (albeit not diffusely) and should always be combined with antiestrogen receptor and CD34 when the differential diagnosis includes endometrial stromal sarcoma.
  • All endometrial stromal sarcomas expressed bcl-2, mostly in a diffuse pattern, but this did not distinguish between endometrial stromal sarcoma and mimics.
  • [MeSH-major] Biomarkers, Tumor / analysis. Endometrial Neoplasms / pathology. Hemangiopericytoma / pathology. Sarcoma, Endometrial Stromal / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Chi-Square Distribution. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Male. Middle Aged. Mucin-1 / analysis. Neprilysin / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptors, Progesterone / analysis

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  • (PMID = 15309019.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Receptors, Progesterone; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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26. Dezanzo P, Lifschitz-Mercer B, Czernobilsky B, Rosai J: Alveolar soft-part sarcoma of paranasal sinuses. Int J Surg Pathol; 2010 Feb;18(1):66-7
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  • [Title] Alveolar soft-part sarcoma of paranasal sinuses.
  • [MeSH-major] Paranasal Sinus Neoplasms / pathology. Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Paraganglioma / diagnosis. Periodic Acid-Schiff Reaction. Perivascular Epithelioid Cell Neoplasms / diagnosis. Young Adult

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  • (PMID = 19926641.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / TFE3 protein, human
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27. Modena P, Lualdi E, Facchinetti F, Galli L, Teixeira MR, Pilotti S, Sozzi G: SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res; 2005 May 15;65(10):4012-9
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  • [Title] SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas.
  • Epithelioid sarcoma is a rare soft tissue neoplasm of uncertain lineage that usually arises in the distal extremities of adults, presents a high rate of recurrences and metastases and frequently poses diagnostic dilemmas.
  • We analyzed SMARCB1/INI1 gene status in nine additional epithelioid sarcoma cases (four proximal types and five conventional types) and altogether we identified deletions of SMARCB1/INI1 gene in 5 of 11 cases, all proximal types.
  • Overall, these results point to SMARCB1/INI1 gene involvement in the genesis and/or progression of epithelioid sarcomas.
  • Analysis of larger series of epithelioid sarcomas will be necessary to highlight putative clinically relevant features related to SMARCB1/INI1 inactivation.
  • [MeSH-major] DNA-Binding Proteins / genetics. Gene Expression Regulation, Neoplastic. Gene Silencing. Sarcoma / genetics
  • [MeSH-minor] Adult. Aged. Cell Line, Tumor. Chromosomal Proteins, Non-Histone. Chromosomes, Human, Pair 22 / genetics. Down-Regulation. Female. Gene Deletion. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors

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  • (PMID = 15899790.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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28. Rutkowski P, Nowecki ZI, Michej W, Debiec-Rychter M, Woźniak A, Limon J, Siedlecki J, Grzesiakowska U, Kakol M, Osuch C, Polkowski M, Głuszek S, Zurawski Z, Ruka W: Risk criteria and prognostic factors for predicting recurrences after resection of primary gastrointestinal stromal tumor. Ann Surg Oncol; 2007 Jul;14(7):2018-27
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  • In univariate analysis, high or intermediate risk group (P < .000001), mitotic index >5/50 high-power field (P < .00001), primary tumor size >5 cm (P < .00001), nongastric primary location (P = .0001), male sex (P = .01), R1 resection/tumor rupture (P = .0003), and epithelioid cell or mixed cell pathological subtype (P = .05) negatively affected DFS.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Prognosis. Registries. Risk Factors

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  • (PMID = 17473953.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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29. Henriques de Figueiredo B, Kantor G, Bui Nguyen Binh M, Duparc A, Guerder C, Stoeckle E, Coindre JM, Bui BN: [Epithelioid sarcoma: a retrospective study of conservative treatment with initial surgery and radiotherapy]. Cancer Radiother; 2007 Sep;11(5):227-33
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  • [Title] [Epithelioid sarcoma: a retrospective study of conservative treatment with initial surgery and radiotherapy].
  • INTRODUCTION: Epithelioid sarcoma is a rare type of soft tissue sarcomas with a high risk of recurrence both local and distant.
  • [MeSH-major] Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm. Female. Follow-Up Studies. Hand. Humans. Knee. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Pectoralis Muscles. Perineum. Postoperative Care. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 17652004.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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30. Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchère-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marquès B, Aubain Somerhausen Nde S, Keslair F, Pedeutour F, Coindre JM: Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group. Am J Surg Pathol; 2007 Sep;31(9):1387-402
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  • [Title] Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group.
  • Most relevant clinicopathologic features of fusion-positive LGFMS included predominance in lower extremities (22/48; thigh: 13/48), deep situation (46/48), and occasional presence of unusual histologic features, for example, hypercellular areas (16/48), foci of epithelioid cells (13/48), and giant rosettes (6/48).
  • Of all, 7/52 non-LGMFS neoplasms contained FUS-CREB3L2 transcripts, of which 4 had been diagnosed as sclerosing epithelioid fibrosarcoma.
  • The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related.
  • [MeSH-major] Basic-Leucine Zipper Transcription Factors / genetics. Biomarkers, Tumor / genetics. Cyclic AMP Response Element-Binding Protein / genetics. Epithelioid Cells / pathology. Fibroma / diagnosis. Fibrosarcoma / diagnosis. Gene Expression Regulation, Neoplastic. Nerve Tissue Proteins / genetics. RNA-Binding Protein FUS / genetics. Translocation, Genetic
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Child. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Molecular Sequence Data. Neoplasm Invasiveness. Paraffin Embedding. Predictive Value of Tests. RNA, Messenger / analysis. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 17721195.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic-Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / CREB3L1 protein, human; 0 / CREB3L2 protein, human; 0 / Cyclic AMP Response Element-Binding Protein; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / RNA-Binding Protein FUS
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31. Fleshman R, Mayerson J, Wakely PE Jr: Fine-needle aspiration biopsy of high-grade sarcoma: a report of 107 cases. Cancer; 2007 Dec 25;111(6):491-8
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  • [Title] Fine-needle aspiration biopsy of high-grade sarcoma: a report of 107 cases.
  • BACKGROUND: To the authors' knowledge, few studies exist demonstrating the reliability of fine-needle aspiration (FNA) biopsy for high-grade sarcoma (HGS).
  • Fifty-four cases were diagnosed as HGS, not otherwise specified, 8 as myxofibrosarcoma, 8 as osteosarcoma, 5 as malignant peripheral nerve sheath tumor, 5 as leiomyosarcoma, 4 as Ewing sarcoma, 4 as liposarcoma, 2 as epithelioid sarcoma, and 1 as angiosarcoma.
  • [MeSH-major] Biopsy, Fine-Needle. Cytodiagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Bone Neoplasms / diagnosis. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Predictive Value of Tests. Reproducibility of Results

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  • (PMID = 17941014.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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32. Lemos MM, Chaves P, Mendonça ME: Is preoperative cytologic diagnosis of epithelioid sarcoma possible? Diagn Cytopathol; 2008 Nov;36(11):780-6
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  • [Title] Is preoperative cytologic diagnosis of epithelioid sarcoma possible?
  • Epithelioid sarcoma (ES) is a rare malignant neoplasm of the soft tissues with a predilection for distal extremities of young adults.
  • The preoperative fine-needle aspiration cytology (FNAC) differential diagnosis with necrotizing granuloma, carcinoma, melanoma, and other neoplasms with epithelioid morphology can be difficult and few cases have been described in the literature.
  • The cytologic features were compared with histologic features as well as with the FNA patterns of other neoplasms with epithelioid morphology that may be included in the differential diagnosis.
  • Cytologic smears showed tumor cells with an epithelioid to spindle cell morphology, dispersed and in loose clusters in close relation with a fibrillar hyaline material.
  • [MeSH-major] Preoperative Care. Sarcoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Neoplasm. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 18831016.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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33. Chbani L, Guillou L, Terrier P, Decouvelaere AV, Grégoire F, Terrier-Lacombe MJ, Ranchère D, Robin YM, Collin F, Fréneaux P, Coindre JM: Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group. Am J Clin Pathol; 2009 Feb;131(2):222-7
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  • [Title] Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group.
  • Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Child. Chromosomal Proteins, Non-Histone / analysis. Combined Modality Therapy. DNA-Binding Proteins / analysis. Female. Humans. Male. Middle Aged. Mitotic Index. Survival Rate. Transcription Factors / analysis. Young Adult

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  • (PMID = 19141382.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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34. Puhaindran ME, Pratt J, Manoso MW, Healey JH, Mintz DN, Athanasian EA: Predictive value of magnetic resonance imaging in determining presence of residual disease after marginal excision of unsuspected soft tissue sarcomas of the hand. J Hand Surg Am; 2010 Sep;35(9):1479-84
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  • PURPOSE: Diagnosis of a soft tissue sarcoma of the hand is at times made only in retrospect after marginal excision of a presumed benign soft tissue mass.
  • We sought to determine the accuracy of MRI in detecting residual sarcoma after marginal excision.
  • A musculoskeletal radiologist, blinded to the sarcoma type, findings on histopathology, and surgery, reviewed 19 scans to see whether the accuracy could be improved.
  • RESULTS: There were 8 epithelioid sarcomas, 6 synovial sarcomas, 4 malignant fibrous histiocytomas, 2 leiomyosarcomas, 2 liposarcomas, 2 myxofibrosarcomas, and one each of 9 other diagnoses.
  • The sensitivity of MRI in detecting residual soft tissue sarcoma of the hand was 60%, specificity was 78%, positive predictive value was 69%, and negative predictive value was 70%.
  • The sensitivity of MRI in detecting gross residual soft tissue sarcoma of the hand was 89%, specificity was 79%, positive predictive value was 62%, and negative predictive value was 95%.
  • CONCLUSIONS: Magnetic resonance imaging does not reliably detect residual gross or microscopic soft tissue sarcoma after marginal excision of unsuspected soft tissue sarcomas of the hand, with residual tumor not readily distinguished from postoperative change.
  • [MeSH-major] Hand / pathology. Magnetic Resonance Imaging / methods. Neoplasm, Residual / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Child. Cohort Studies. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Reoperation. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Surgical Procedures, Operative / methods. Young Adult

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  • [Copyright] Copyright 2010. Published by Elsevier Inc.
  • (PMID = 20807625.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Blizniukov OP, Smirnova EA: [Sclerosing epithelial fibrosarcoma: a clinico-morphological evaluation of 10 cases]. Vopr Onkol; 2009;55(5):586-93
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  • Differentiated analysis of epithelioid fibrosarcoma may also be done by computed microscopy and immunomorphology using other tumor models consisting of light-cytoplasm epitheloid cells, mostly osteosarcoma, clear-cell renal carcinoma, melanoma, synovial sarcoma and clear-cell sarcoma of the tendon sheath and aponeurosis.
  • [MeSH-major] Biomarkers, Tumor / analysis. Epithelioid Cells / pathology. Fibrosarcoma / diagnosis
  • [MeSH-minor] Abdomen. Adult. Back. Female. Humans. Leg. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Sclerosis. Thorax

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  • (PMID = 20020654.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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36. Coulibaly B, Tasei AM, Payan-Defais MJ, Bouvier C, Trousse D, Doddoli C, Figarella-Branger D: [Pulmonary epithelioid haemangioendothelioma: two different clinical courses]. Rev Mal Respir; 2008 Sep;25(7):867-70
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  • [Title] [Pulmonary epithelioid haemangioendothelioma: two different clinical courses].
  • In both cases, chest radiography and thoracic CT scans showed multiple, bilateral pulmonary nodules, bronchial endoscopy was normal and surgical biopsy revealed epithelioid haemangioendothelioma.
  • Epithelioid haemangioendothelioma is a vascular tumour usually affecting women less than 40 years of age.
  • Epithelioid haemangioendothelioma is considered a sarcoma without precise histological prognostic criteria.
  • [MeSH-major] Hemangioendothelioma, Epithelioid. Lung Neoplasms
  • [MeSH-minor] Biopsy. Female. Follow-Up Studies. Humans. Lung / pathology. Male. Middle Aged. Radiography, Thoracic. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 18946414.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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37. Raoux D, Péoc'h M, Pedeutour F, Vaunois B, Decouvelaere AV, Folpe AL: Primary epithelioid sarcoma of bone: report of a unique case, with immunohistochemical and fluorescent in situ hybridization confirmation of INI1 deletion. Am J Surg Pathol; 2009 Jun;33(6):954-8
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  • [Title] Primary epithelioid sarcoma of bone: report of a unique case, with immunohistochemical and fluorescent in situ hybridization confirmation of INI1 deletion.
  • We report the clinical and pathologic features of, what is to the best of our knowledge, the first case of epithelioid sarcoma of bone.
  • Histologically, the tumor consisted of relatively uniform but clearly malignant-appearing epithelioid cells, with scattered rhabdoid-appearing cells.
  • An extensive clinical and radiographic workup did not show evidence of a soft tissue tumor, and the diagnosis of a primary epithelioid sarcoma of bone was made.
  • Awareness that epithelioid sarcoma may occur in bone, careful histologic evaluation and ancillary immunohistochemistry for epithelial markers, CD34 and INI1 protein should allow for recognition of such tumors.
  • Study of additional cases of primary epithelioid sarcoma of bone will be necessary to better understand its clinical behavior.
  • [MeSH-major] Bone Neoplasms / genetics. Bone Neoplasms / pathology. Chromosomal Proteins, Non-Histone / biosynthesis. Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / biosynthesis. DNA-Binding Proteins / genetics. Sarcoma / genetics. Sarcoma / pathology. Transcription Factors / biosynthesis. Transcription Factors / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Gene Deletion. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Tomography, X-Ray Computed


38. Stacy GS, Nair L: Magnetic resonance imaging features of extremity sarcomas of uncertain differentiation. Clin Radiol; 2007 Oct;62(10):950-8
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  • The purpose of this review is to illustrate the pertinent clinical and imaging features of extremity sarcomas of uncertain differentiation, including synovial sarcoma, epithelioid sarcoma, clear-cell sarcoma, and alveolar soft part sarcoma.
  • These tumours should be considered in the differential diagnosis when a soft-tissue mass is encountered in the extremity of an adolescent or young adult.
  • [MeSH-major] Forearm. Leg. Magnetic Resonance Imaging. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Clin Radiol. 2007 Oct;62(10):959-60 [17765460.001]
  • (PMID = 17765459.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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39. Collini P, Sorensen PH, Patel S, Blay JY, Issels RD, Maki RG, Eriksson M, del Muro XG: Sarcomas with spindle cell morphology. Semin Oncol; 2009 Aug;36(4):324-37
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  • In the days before the term "high-grade undifferentiated pleomorphic sarcoma" came into use, one of the most common sarcoma diagnoses was "malignant fibrous histiocytoma," and before that, in an era before immunohistochemistry, "fibrosarcoma" was used to describe most sarcomas.
  • "Spindle cell" is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population.
  • As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology.
  • In comparison to small round cell sarcomas such as Ewing sarcoma, the use of adjuvant chemotherapy remains controversial, and the sensitivity of these tumors to chemotherapy in the metastatic setting is highly variable.
  • [MeSH-major] Sarcoma / pathology
  • [MeSH-minor] Chemotherapy, Adjuvant. Fibrosarcoma / genetics. Fibrosarcoma / pathology. Gene Fusion. Heat-Shock Response. Humans. Hyperthermia, Induced. Protein Kinase Inhibitors / therapeutic use. Sarcoma, Synovial / genetics. Sarcoma, Synovial / pathology. Translocation, Genetic

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  • (PMID = 19664493.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors
  • [Number-of-references] 62
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40. Vermi W, Lonardi S, Bosisio D, Uguccioni M, Danelon G, Pileri S, Fletcher C, Sozzani S, Zorzi F, Arrigoni G, Doglioni C, Ponzoni M, Facchetti F: Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. J Pathol; 2008 Nov;216(3):356-64
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  • [Title] Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma.
  • In contrast, no data are available on CXCL13 expression on FDC sarcoma (FDC-S) cells.
  • In addition to the potential biological relevance of this expression, the use of reagents directed against CXCL13 can be useful to properly identify the origin of spindle cell and epithelioid neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Chemokine CXCL13 / analysis. Dendritic Cells, Follicular / immunology. Sarcoma / immunology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Giant Lymph Node Hyperplasia / immunology. Humans. Immunohistochemistry. In Situ Hybridization / methods. Lymph Nodes / immunology. Male. Middle Aged. Palatine Tonsil / immunology. RNA, Messenger / analysis. Receptors, CXCR5 / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. T-Lymphocytes / metabolism

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  • [Copyright] (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 18792075.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CXCL13 protein, human; 0 / Chemokine CXCL13; 0 / RNA, Messenger; 0 / Receptors, CXCR5
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41. Rekhi B, Ingle A, Kumar R, DeSouza MA, Dikshit R, Jambhekar NA: Malignant peripheral nerve sheath tumors: clinicopathological profile of 63 cases diagnosed at a tertiary cancer referral center in Mumbai, India. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):611-8
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  • BACKGROUND: A malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma, characterized by an aggressive course and forms a diagnostic challenge, in view of its varied histomorphology.
  • Two cases showed epithelioid differentiation.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Child. Female. Histocytochemistry. Humans. India. Male. Microscopy. Middle Aged. Recurrence. Severity of Illness Index. Survival Analysis. Young Adult

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  • (PMID = 21045379.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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42. Irving JA, Lerwill MF, Young RH: Gastrointestinal stromal tumors metastatic to the ovary: a report of five cases. Am J Surg Pathol; 2005 Jul;29(7):920-6
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  • Microscopically, three tumors had a pure spindle cell morphology, and two both spindle and epithelioid cell components.
  • Other differential considerations, including endometrial stromal sarcoma and fibrosarcoma, are discussed.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Intestinal Neoplasms / metabolism. Intestinal Neoplasms / pathology. Middle Aged. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology

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  • (PMID = 15958857.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Hornick JL, Fletcher CD: Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol; 2008 Apr;32(4):493-501
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  • PEComas (tumors showing perivascular epithelioid cell differentiation) are a family of mesenchymal neoplasms that include angiomyolipoma, clear cell "sugar" tumor of the lung, lymphangiomyomatosis, and a group of uncommon lesions that arise in soft tissue, visceral organs, and skin.
  • The tumors were composed of cords and trabeculae of cytologically uniform bland epithelioid cells with palely eosinophilic, granular to clear cytoplasm and round nuclei with small nucleoli, embedded in abundant densely sclerotic stroma.
  • [MeSH-major] Epithelioid Cells / pathology. Neoplasms, Connective and Soft Tissue / pathology. Retroperitoneal Neoplasms / pathology. Stromal Cells / pathology
  • [MeSH-minor] Actins / analysis. Adult. Aged. Antigens, Neoplasm / analysis. Calmodulin-Binding Proteins / analysis. Desmin / analysis. Female. Follow-Up Studies. Humans. Hyalin / metabolism. Immunohistochemistry. MART-1 Antigen. Melanoma-Specific Antigens. Microphthalmia-Associated Transcription Factor / analysis. Middle Aged. Mitotic Index. Mucin-1 / analysis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. S100 Proteins / analysis. Sarcoma / pathology. Sclerosis. Time Factors. Treatment Outcome

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  • (PMID = 18223480.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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44. Zheng YY, Zhou XG, Zhang SH, Zhang YN: [Histiocytic sarcoma: a clinicopathologic study of 6 cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Feb;39(2):79-83
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  • [Title] [Histiocytic sarcoma: a clinicopathologic study of 6 cases].
  • OBJECTIVE: To study the morphologic features, immunophenotypes, differential diagnoses and prognosis of histiocytic sarcoma (HS).
  • The tumor was composed of sheets of large epithelioid cells with abundant eosinophilic cytoplasm, oval to irregular nuclei, vesicular chromatin and large nucleoli.
  • [MeSH-major] Histiocytic Sarcoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large-Cell, Anaplastic / metabolism. Lymphoma, Large-Cell, Anaplastic / pathology. Male. Melanoma / metabolism. Melanoma / pathology. Muramidase / metabolism. Prognosis. Receptors, Cell Surface / metabolism. Young Adult

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  • (PMID = 20388371.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD163 antigen; 0 / CD68 antigen, human; 0 / Receptors, Cell Surface; EC 3.2.1.17 / Muramidase
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45. Grivas A, Trafalis DT, Thanopoulou E, Ziras NG, Athanasiou AE: Treatment with trabectedin: should be indicated to all soft tissue sarcoma histotypes? J BUON; 2010 Oct-Dec;15(4):791-3
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  • [Title] Treatment with trabectedin: should be indicated to all soft tissue sarcoma histotypes?
  • Trabectedin is a novel antineoplastic agent approved as monotherapy in patients with advanced soft tissue sarcoma (STS) after failure of standard therapy with anthracyclines or ifosfamide, or patients who are unsuited to receive these agents.
  • We report on two patients suffering from infrequent subtypes of STSs, fibrosarcoma and epithelioid sarcoma, who were treated with trabectedin.
  • [MeSH-major] Antineoplastic Agents, Alkylating / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dioxoles / adverse effects. Fibrosarcoma / drug therapy. Sarcoma / drug therapy. Tetrahydroisoquinolines / adverse effects
  • [MeSH-minor] Adult. Female. Humans. Lung Neoplasms / chemically induced. Lung Neoplasms / secondary. Male. Prognosis

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  • (PMID = 21229647.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Dioxoles; 0 / Tetrahydroisoquinolines; 114899-77-3 / trabectedin
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46. Flucke U, Hulsebos TJ, van Krieken JH, Mentzel T: Myxoid epithelioid sarcoma: a diagnostic challenge. A report on six cases. Histopathology; 2010 Nov;57(5):753-9
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  • [Title] Myxoid epithelioid sarcoma: a diagnostic challenge. A report on six cases.
  • AIMS: Epithelioid sarcoma (ES) is a distinct sarcoma-type with a specific morphology and immunophenotype.
  • [MeSH-major] Myoepithelioma / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Female. Humans. Male. Middle Aged. Transcription Factors / genetics

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21083605.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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47. Guo Y, Tian GL: [Clinical analysis of 16 cases of epithelioid sarcoma]. Zhonghua Wai Ke Za Zhi; 2005 Aug 15;43(16):1066-8
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  • [Title] [Clinical analysis of 16 cases of epithelioid sarcoma].
  • METHODS: Review the clinical findings, pathologic features and results of the treatment of 16 cases of the epithelioid sarcoma in extremities, which were treated in our hospital from 1992 to 2004.
  • [MeSH-major] Sarcoma. Soft Tissue Neoplasms
  • [MeSH-minor] Adolescent. Adult. Extremities. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 16194334.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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48. Niimi R, Matsumine A, Kusuzaki K, Okamura A, Matsubara T, Uchida A, Fukutome K: Soft-tissue sarcoma mimicking large haematoma: a report of two cases and review of the literature. J Orthop Surg (Hong Kong); 2006 Apr;14(1):90-5
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  • [Title] Soft-tissue sarcoma mimicking large haematoma: a report of two cases and review of the literature.
  • In the second patient with epithelioid sarcoma of the forearm, fasciotomy was repeatedly performed for compartment syndrome arising from the tumour.
  • [MeSH-major] Buttocks. Forearm. Hematoma / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 16598096.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 26
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49. Cascio MJ, O'Donnell RJ, Horvai AE: Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare. Mod Pathol; 2010 Apr;23(4):574-80
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  • [Title] Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare.
  • Epithelioid sarcoma is a rare, malignant, soft tissue neoplasm that can be classified into proximal, distal and fibroma-like subtypes.
  • Regardless of subtype, epithelioid sarcoma often shows morphologic and immunophenotypic evidence of epithelial differentiation.
  • EGFR expression has been reported in some sarcoma types, but expression, amplification and mutations have not been studied in epithelioid sarcoma.
  • We evaluated 15 cases of epithelioid sarcoma from 14 patients for EGFR expression using immunohistochemistry, EGFR copy number aberration using fluorescence in situ hybridization and screened for mutations in the tyrosine kinase domain of the EGFR gene using direct sequencing.
  • In all, 14 of the 15 epithelioid sarcomas (93%) showed expression of EGFR by immunohistochemistry.
  • These results imply that although EGFR is expressed in most epithelioid sarcomas regardless of subtype, gene amplification and activating mutations in the tyrosine kinase domain appear to be rare or absent.
  • Thus, the benefit of targeted therapy against EGFR in patients with epithelioid sarcoma remains to be determined.
  • [MeSH-major] Receptor, Epidermal Growth Factor / genetics. Sarcoma / genetics. Sarcoma / metabolism. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. DNA Mutational Analysis. Female. Gene Amplification. Gene Dosage. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged


50. Saithna A, Pynsent PB, Grimer RJ: Retrospective analysis of the impact of symptom duration on prognosis in soft tissue sarcoma. Int Orthop; 2008 Jun;32(3):381-4
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  • [Title] Retrospective analysis of the impact of symptom duration on prognosis in soft tissue sarcoma.
  • The objective was to assess whether time to diagnosis is influenced by patient/tumour-related factors and whether or not duration of symptoms has any impact on survival in soft tissue sarcoma.
  • Patient and tumour-related factors significantly associated with longer symptom duration were low-grade, subcutaneous tumours, and epithelioid or synovial sarcoma.
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Factors. Time Factors

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  • [Cites] J Clin Oncol. 2002 Nov 1;20(21):4344-52 [12409334.001]
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  • (PMID = 17377790.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2323426
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51. Zheng JM, Tao X, Xu AM, Chen XF, Wu MC, Zhang SH: Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. Histopathology; 2007 Aug;51(2):195-203
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  • [Title] Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis.
  • AIMS: To evaluate primary and recurrent embryonal sarcoma of the liver and to improve recognition of its morphological variants and immunohistochemical features.
  • METHODS AND RESULTS: Fourteen primary and two recurrent cases of hepatic embryonal sarcoma were evaluated histologically and investigated immunohistochemically with a panel of antibodies using the EnVision+ system.
  • Microscopic features included spindle, oval, stellate, epithelioid or multinucleated cells loosely or densely arranged in a myxomatous matrix.
  • CONCLUSIONS: Embryonal sarcoma of the liver may undergo pluripotential differentiation and diagnosis should be based mainly on morphological features.
  • [MeSH-minor] Actins / metabolism. Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Differentiation. Child. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Proteins / metabolism. alpha 1-Antitrypsin / metabolism. alpha-Fetoproteins

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  • (PMID = 17573940.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / Actins; 0 / Biomarkers, Tumor; 0 / Proteins; 0 / alpha 1-Antitrypsin; 0 / alpha-Fetoproteins
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52. Casanova M, Ferrari A, Collini P, Bisogno G, Alaggio R, Cecchetto G, Gronchi A, Meazza C, Garaventa A, Di Cataldo A, Carli M, Italian Soft Tissue Sarcoma Committee: Epithelioid sarcoma in children and adolescents: a report from the Italian Soft Tissue Sarcoma Committee. Cancer; 2006 Feb 1;106(3):708-17
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  • [Title] Epithelioid sarcoma in children and adolescents: a report from the Italian Soft Tissue Sarcoma Committee.
  • BACKGROUND: Epithelioid sarcoma (ES) is an uncommon malignant soft tissue tumor.
  • The current study concerns 30 patients age<18 years who were enrolled in the Italian Soft Tissue Sarcoma Committee protocols.
  • The current study data do not clearly confirm the strong tendency for the lymph node involvement described in adult ES patients.
  • [MeSH-major] Sarcoma / therapy. Soft Tissue Neoplasms / therapy


53. Yang L, Ding YQ, Zhao T, Deng YJ: [Primary epithelioid sarcoma of the scalp: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2007 Dec;36(12):861-2
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  • [Title] [Primary epithelioid sarcoma of the scalp: report of a case].
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / pathology. Sarcoma / diagnosis. Sarcoma / pathology. Scalp / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Humans. Magnetic Resonance Imaging. Male. Meninges / pathology. Skull / pathology


54. Mentzel T: [Epithelioid sarcoma: morphologic variants and differential diagnosis]. Pathologe; 2010 Mar;31(2):135-41
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  • [Title] [Epithelioid sarcoma: morphologic variants and differential diagnosis].
  • Epithelioid sarcoma represents a rare sarcoma with a poor long-term prognosis that arises predominantly on the distal extremities of young adult patients, often mimicking a benign, non-neoplastic condition.
  • Histologically, epithelioid sarcoma is characterized by a multinodular growth with central necrosis, and the neoplasms are composed of relatively uniform epithelioid tumour cells showing a coexpression of vimentin, epithelial membrane antigen and pancytokeratin, and in about half of the cases of CD34.
  • Interestingly, most cases of epithelioid sarcoma show a loss of INI1, whereas the inactivation of the tumour suppressor gene SMARCB1/INI1 is only rarely caused by mutation.
  • The proximal variant of epithelioid sarcoma is composed of confluent sheets of enlarged epithelioid and rhabdoid tumour cells and represents the morphological progression of this entity.
  • The fibroma-like variant of epithelioid sarcoma as well as the angiomatoid and myxoid variants of epithelioid sarcoma are rare morphological variants and need to be considered in the differential diagnosis of other benign and malignant neoplasms.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19997734.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 21
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55. Koga T, Ushijima K, Kage M, Ichiki M, Kitajima T, Narita Y, Mizoguchi Y, Hanada M, Ehara R, Nishimura M, Takamori S, Aizawa H: Pulmonary metastasis of endometrial stromal sarcoma. Kurume Med J; 2006;53(3-4):95-7
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  • [Title] Pulmonary metastasis of endometrial stromal sarcoma.
  • Morphological characteristics of the thracoscopically resected lung tumors suggested low-grade endometrial stromal sarcoma (ESS), and immunostaining revealed that the tumor cells were positive for progesterone and estrogen receptors, CD10 and vimentin, confirming a diagnosis of ESS.
  • ESS is an uncommon uterine neoplasm, however, may be mistaken as benign tumors such as epithelioid leiomyoma, and occasionally metastasizes to remote organs such as lungs even after long disease-free period, posing diagnostic challenge.
  • [MeSH-major] Endometrial Neoplasms / pathology. Lung Neoplasms / secondary. Sarcoma, Endometrial Stromal / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 17317938.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Tucci E, Della Rocca C, Santilli F: Localized bacillary angiomatosis in the oral cavity: observations about a neoplasm with atypical behavior. Description of a case and review of the literature. Minerva Stomatol; 2006 Jan-Feb;55(1-2):67-75
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  • Bacillary angiomatosis can be clinically similar to the Kaposi's sarcoma and histologically confused with angiosarcoma, epitheloid hemangioma and pyogenic granuloma.
  • The high tendency to relapse, the capability in migration and to involve several localizations at the same time have induced the authors to deepen the research to exclude the possibility that it could be a Kaposi's sarcoma or a pyogenic granuloma and to get to an accurate diagnosis in order to resolve the disease.
  • [MeSH-minor] Adolescent. Adult. Ampicillin / analogs & derivatives. Ampicillin / therapeutic use. Bartonella henselae / pathogenicity. Bartonella quintana / pathogenicity. Child. Chlorhexidine / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Female. Gingival Neoplasms / diagnosis. Granuloma, Pyogenic / diagnosis. Hemangioendothelioma, Epithelioid / diagnosis. Hemangiosarcoma / diagnosis. Humans. Male. Pregnancy. Pregnancy Complications, Neoplastic / diagnosis. Recurrence. Sarcoma, Kaposi / diagnosis. Tooth Extraction

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  • (PMID = 16495874.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 7C782967RD / Ampicillin; 8GM2J22278 / bacampicillin; R4KO0DY52L / Chlorhexidine
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57. Kozawa E, Irisawa M, Heshiki A, Okagaki R, Shimizu Y: Magnetic resonance imaging findings of vulvar epithelioid sarcoma. Radiat Med; 2008 Jul;26(6):376-8
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  • [Title] Magnetic resonance imaging findings of vulvar epithelioid sarcoma.
  • We describe here a case of vulvar epithelioid sarcoma.
  • Epithelioid sarcoma is a malignant appendicular skin tumor that is rarely of vulvar origin.
  • To our knowledge, this is the first case of vulvar epithelioid sarcoma described in the MRI literature.
  • [MeSH-major] Magnetic Resonance Imaging. Sarcoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Young Adult


58. Vajtai I, Kuhlen D, Kappeler A, Mariani L, Zimmermann A, Paulus W: Rapid spontaneous malignant progression of supratentorial tanycytic ependymoma with sarcomatous features - "Ependymosarcoma". Pathol Res Pract; 2010 Jul 15;206(7):493-8
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  • The sarcomatous moiety consisted of spindle and epithelioid cells densely interwoven with reticulin fibers.
  • While the ependymal component was GFAP and S100 protein positive, and featured punctate staining for EMA, none of these markers was expressed in the adjacent sarcoma.
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Immunophenotyping. Magnetic Resonance Imaging

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19853384.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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59. El Bouanani A, Saidi H, Fikry T: [Rare localization of an aggressive epithelioid sarcoma in an adolescent]. Chir Main; 2010 Sep;29(4):266-9
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  • [Title] [Rare localization of an aggressive epithelioid sarcoma in an adolescent].
  • Epithelioid sarcoma is a rare soft-tissue sarcoma affecting mostly young adult males.
  • We report a case of epithelioid sarcoma of the left arm in a 16-year old adolescent of 8 months duration.
  • [MeSH-major] Arm / pathology. Neoplasm Recurrence, Local / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20724204.001).
  • [ISSN] 1769-6666
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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60. Rekhi B, Gorad BD, Chinoy RF: Clinicopathological features with outcomes of a series of conventional and proximal-type epithelioid sarcomas, diagnosed over a period of 10 years at a tertiary cancer hospital in India. Virchows Arch; 2008 Aug;453(2):141-53
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  • [Title] Clinicopathological features with outcomes of a series of conventional and proximal-type epithelioid sarcomas, diagnosed over a period of 10 years at a tertiary cancer hospital in India.
  • Epithelioid sarcoma (ES) is an uncommon sarcoma.
  • This unusual sarcoma, with characteristic growth patterns, merits a proper histological evaluation, as it has many mimics.
  • [MeSH-major] Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Arm / pathology. Child. Female. Humans. India / epidemiology. Kaplan-Meier Estimate. Leg / pathology. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • [Cites] Gynecol Oncol. 1980 Apr;9(2):237-46 [7372196.001]
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  • (PMID = 18607629.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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61. Sanou R, Bazin C, Krakowski I, Boccaccini H, Mathias J, Beot S, Marchal F, Regent D: [Radiofrequency ablation for palliation of soft tissue tumor pain]. J Radiol; 2010 Mar;91(3 Pt 1):281-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analgesia. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Follow-Up Studies. Humans. Leiomyosarcoma / secondary. Leiomyosarcoma / surgery. Male. Middle Aged. Narcotics / administration & dosage. Pain / surgery. Pain Measurement. Perivascular Epithelioid Cell Neoplasms / surgery. Radiography, Interventional. Retrospective Studies. Sarcoma / secondary. Sarcoma / surgery. Tomography, X-Ray Computed. Ultrasonography, Interventional

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  • (PMID = 20508558.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Narcotics
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62. Brassesco MS, Valera ET, Castro-Gamero AM, Moreno DA, Silveira TP, Mori BM, Engel EE, Scrideli CA, Tone LG: Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report. Genet Mol Res; 2009;8(4):1211-7
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  • [Title] Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report.
  • Epithelioid sarcoma is a rare, aggressive soft tissue tumor of unknown histogenesis showing predominantly epithelioid cytomorphology.
  • We conducted a conventional and molecular cytogenetic study of a 27-year-old male with epithelioid sarcoma with angiomatoid features.
  • Cytogenetic analysis of epithelioid sarcoma metaphase spreads by GTG-banding revealed a diploid chromosome complement with structural and numerical aberrations.
  • Genetic evaluation of this rare condition may be useful in determining if epithelioid sarcoma is associated with a distinct genetic background.
  • [MeSH-major] Chromosome Aberrations. Sarcoma / genetics
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. In Situ Hybridization, Fluorescence. Male. Polymerase Chain Reaction


63. Padilla-Rodríguez AL, Bembassat M, Lazaro M, Ortiz-Hidalgo C: Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. Appl Immunohistochem Mol Morphol; 2007 Sep;15(3):346-52
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  • [Title] Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis.
  • Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor arising most frequently in lymph nodes with only few reports of extranodal locations.
  • Histologically the tumor was composed of highly pleomorphic cells exhibiting some uncommon features such as an epithelioid appearance, cystic spaces, and multinucleated cells with morphologic features of emperipolesis.

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  • (PMID = 17721283.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Complement 3b; 0 / Receptors, Complement 3d; 0 / Receptors, IgE
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64. Maksymiuk B, Smok-Ragankiewicz A, Snietura M, Lange D, Słomian G: Diagnostic problems concerning epithelioid sarcoma--case analysis. Pol J Pathol; 2005;56(3):139-44
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  • [Title] Diagnostic problems concerning epithelioid sarcoma--case analysis.
  • We discuss here five cases of epithelioid sarcoma (ES) with final diagnosis established after reexamination of initial findings.
  • Problems with differential diagnosis of these neoplasms arise since their microscopic picture may simulate several other pathological conditions such as non-neoplastic granulomatous reactions, squamous cell carcinomas and adenocarcinomas, melanomas and soft tissue sarcomas with epithelioid component.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Antigens, CD34 / metabolism. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Granuloma / pathology. Humans. Immunohistochemistry. Keratins / metabolism. Male. Melanoma / pathology. Middle Aged. Mucin-1 / metabolism. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 16334982.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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65. Herr MJ, Harmsen WS, Amadio PC, Scully SP: Epithelioid sarcoma of the hand. Clin Orthop Relat Res; 2005 Feb;(431):193-200
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  • [Title] Epithelioid sarcoma of the hand.
  • Twenty-eight patients were treated for a primary epithelioid sarcoma of the hand.
  • Twenty-seven patients (96%) had excisions before evaluation, including 11 (39%) with multiple prior excisions with varying diagnoses before epithelioid sarcoma, and all had surgical treatment after referral.
  • [MeSH-major] Hand. Sarcoma
  • [MeSH-minor] Adult. Amputation. Disease-Free Survival. Female. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local

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  • (PMID = 15685075.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Herzog CE: Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol; 2005 Apr;27(4):215-8
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  • [Title] Overview of sarcomas in the adolescent and young adult population.
  • However, there are numerous different histologic types, and any given type of sarcoma is extremely rare.
  • In an effort to estimate the frequency and absolute numbers of different sarcomas in the adolescent and young adult population, the University of Texas M. D.
  • Based on this query, an overview of sarcomas that occur predominantly in the adolescent and young adult (AYA) population is presented.
  • These sarcomas include rhabdomyosarcoma, synovial sarcoma, neurogenic sarcoma, epithelioid sarcomas, alveolar soft parts sarcoma, Ewing sarcoma, and osteosarcoma.
  • Using the percentages for occurrence of each histologic type determined from the MDACC database, and the SEER estimate of overall sarcoma incidence, an estimate of the number of new cases in 2004 for the predominant histologic types occurring in the AYA population are presented.
  • [MeSH-major] Bone Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Humans. Middle Aged. SEER Program

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  • (PMID = 15838394.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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67. Tsakonas GP, Kallistratos MS, Balamoti EK, Gassiamis A, Zizi-Sermpetzoglou A, Mylonakis N, Karabelis A, Kosmas C: Rare and aggressive metastatic, axial multifocal local epithelioid sarcoma associated with paraneoplastic granulocytosis and hypoglycaemia. Lancet Oncol; 2007 Jan;8(1):82-4
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  • [Title] Rare and aggressive metastatic, axial multifocal local epithelioid sarcoma associated with paraneoplastic granulocytosis and hypoglycaemia.
  • [MeSH-major] Granulocytes / pathology. Hypoglycemia. Paraneoplastic Syndromes. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / therapy


68. Eyden B: The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions. J Submicrosc Cytol Pathol; 2005 Nov;37(3-4):231-96
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  • Ultrastructural features are described of nodular fasciitis, the myofibromatoses (including Dupuytren's disease), inflammatory myofibroblastic tumour, post-operative spindle cell nodule, fibroma of tendon sheath, fibrous pseudotumour, benign fibrous histiocytoma, atypical fibroxanthoma, dermatofibrosarcoma protuberans, myofibrosarcoma (myofibroblastic sarcoma), malignant fibrous histiocytoma (pleomorphic myofibrosarcoma), epithelioid sarcoma and spindle-cell carcinoma.
  • [MeSH-minor] Adolescent. Adult. Animals. Female. Humans. Male. Microscopy, Electron, Transmission

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  • (PMID = 16612972.001).
  • [ISSN] 1122-9497
  • [Journal-full-title] Journal of submicroscopic cytology and pathology
  • [ISO-abbreviation] J. Submicrosc. Cytol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 344
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69. Koga K, Nabeshima K, Aoki M, Kawakami T, Hamasaki M, Toole BP, Nakayama J, Iwasaki H: Emmprin in epithelioid sarcoma: expression in tumor cell membrane and stimulation of MMP-2 production in tumor-associated fibroblasts. Int J Cancer; 2007 Feb 15;120(4):761-8
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  • [Title] Emmprin in epithelioid sarcoma: expression in tumor cell membrane and stimulation of MMP-2 production in tumor-associated fibroblasts.
  • This study investigated the expression and role of emmprin in epithelioid sarcoma (ES).
  • [MeSH-major] Antigens, CD147 / metabolism. Cell Membrane / metabolism. Epithelioid Cells / metabolism. Fibroblasts / metabolism. Matrix Metalloproteinase 2 / metabolism. Sarcoma / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Coculture Techniques. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Tumor Cells, Cultured

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  • (PMID = 17131322.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 136894-56-9 / Antigens, CD147; EC 3.4.24.24 / Matrix Metalloproteinase 2
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70. Abbas O, Ghosn S, Chedraoui A, Kibbi AG: Giant fleshy mass over the left axilla. Epithelioid sarcoma (ES) (metastatic). Arch Dermatol; 2009 May;145(5):589-94
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  • [Title] Giant fleshy mass over the left axilla. Epithelioid sarcoma (ES) (metastatic).
  • [MeSH-major] Lymph Nodes / pathology. Sarcoma / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Axilla. Biopsy. Diagnosis, Differential. Humans. Lymphatic Metastasis. Male


71. Bioulac-Sage P, Laumonier H, Laurent C, Blanc JF, Balabaud C: Benign and malignant vascular tumors of the liver in adults. Semin Liver Dis; 2008 Aug;28(3):302-14
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  • Vascular tumors of the liver in adult patients include cavernous hemangioma, a common benign tumor; epithelioid hemangioendothelioma, a rare, usually low-grade malignant tumor; and angiosarcoma, a rare and very aggressive tumor.
  • A definitive diagnosis of epithelioid hemangioendothelioma and angiosarcoma requires histopathologic examination.
  • Liver transplantation at an early stage has greatly improved the prognosis of epithelioid hemangioendothelioma.
  • [MeSH-minor] Adult. Hemangioendothelioma, Epithelioid / pathology. Hemangioendothelioma, Epithelioid / therapy. Hemangioma, Cavernous / pathology. Hemangioma, Cavernous / therapy. Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Hepatic Stellate Cells / pathology. Humans. Sarcoma, Kaposi / pathology. Sarcoma, Kaposi / therapy. Treatment Outcome

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  • (PMID = 18814083.001).
  • [ISSN] 0272-8087
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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72. Al-Daraji WI, Makhlouf HR, Miettinen M, Montgomery EA, Goodman ZD, Marwaha JS, Fanburg-Smith JC: Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. Am J Surg Pathol; 2009 Jun;33(6):826-34
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  • [Title] Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma.
  • BACKGROUND: Primary gallbladder sarcoma (PGBS) is rare, with only 39 documented cases, with the predominant type being leiomyosarcoma.
  • DESIGN: Cases recorded as "gallbladder sarcoma" were retrieved from our files; the clinicopathologic features were reviewed and recorded.
  • Epithelial tumors, mixed tumors (carcinosarcoma or sarcomatoid carcinoma), tumors extending into the gallbladder from the abdomen, or sarcoma with other known primaries were excluded.
  • RESULT: PGBS occurred in 4 males and 11 females with the adult median age of 68.5 (range: 24 to 88 y, n=12) and 3 children ages 1.5 to 3 years, the latter all with botryoid embryonal rhabdomyosarcoma.
  • PGBSs were diagnosed as 7 myxofibrosarcomas [malignant fibrous histiocytoma, storiform pleomorphic to myxoid, 2 with an unusual fibromyxoid sarcoma-like (Evans-like), and pleomorphic hyalinizing angiectatic tumor-like mixture], 2 leiomyosarcomas, 1 gastrointestinal stromal tumor-like (GIST-like), 3 botryoid embryonal rhabdomyosarcomas (RMS), and 2 epithelioid angiosarcomas.
  • The GIST-like sarcoma was palisaded and myoid-like but failed to stain for CD34 or CD117.
  • Angiosarcomas demonstrated an extravascular proliferation of atypical epithelioid endothelial cells, and mitotic activity.
  • A variety of sarcoma types are found, yet malignant fibrous histiocytoma is the predominant variant, more common than LMS.
  • GIST is a controversial sarcoma in gallbladder; angiosarcoma can rarely occur in this location.
  • [MeSH-major] Gallbladder Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Prognosis

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  • (PMID = 19194282.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Sakamoto A, Jono O, Hirahashi M, Oya M, Iwamoto Y, Arai K: Epithelioid sarcoma with muscle metastasis detected by positron emission tomography. World J Surg Oncol; 2008;6:84
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  • [Title] Epithelioid sarcoma with muscle metastasis detected by positron emission tomography.
  • BACKGROUND: Epithelioid sarcoma is an uncommon high-grade sarcoma, mostly involving the extremities.
  • Diagnosis of epithelioid sarcoma was made by open biopsy, and amputation at the upper arm was then undertaken.
  • CONCLUSION: Increased uptake on FDG-PET might be representative of epithelioid sarcoma, and for this reason FDG-PET may be useful for detecting metastasis.
  • Muscle metastasis is not well documented in epithelioid sarcoma.
  • [MeSH-major] Fluorodeoxyglucose F18. Muscle Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Sarcoma / radionuclide imaging. Soft Tissue Neoplasms / radiography
  • [MeSH-minor] Adult. Biopsy. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 18706085.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2527488
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74. Steffensen TS, Gilbert-Barness E, Wagoner MJ, Bui MM, Browarsky IL: Human chorionic gonadotrophin producing epithelioid sarcoma metastatic to the placenta. Fetal Pediatr Pathol; 2008;27(6):282-91
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  • [Title] Human chorionic gonadotrophin producing epithelioid sarcoma metastatic to the placenta.
  • Pregnancy complicated by sarcoma is a rare event, and metastasis to the placenta is exceptionally rare.
  • We report the first case of placental metastasis of an epithelioid sarcoma, an uncommon malignancy which most frequently affects young adults.
  • In addition to the typical histological features and immunophenotypic profile expected of epithelioid sarcoma, this tumor also expressed human chorionic gonadotrophin (HCG).
  • [MeSH-major] Chorionic Gonadotropin / metabolism. Placenta / pathology. Placenta Diseases / pathology. Pregnancy Complications, Neoplastic / pathology. Sarcoma / secondary
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Pregnancy. Young Adult


75. Périgny M, Dion N, Couture C, Lagacé R: [Low grade fibromyxoid sarcoma: a clinico-pathologic analysis of 7 cases]. Ann Pathol; 2006 Dec;26(6):419-25
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  • [Title] [Low grade fibromyxoid sarcoma: a clinico-pathologic analysis of 7 cases].
  • OBJECTIVES: Low-grade fibromyxoid sarcoma (LGFMS) is a malignant soft tissue tumor.
  • One of them demonstrated an area of dedifferentiation into a high grade pleomorphic sarcoma, malignant fibrous histiocytoma (MFH) type.
  • We report a unique case with areas of high grade sarcoma, MFH type, and areas similar to sclerosing epithelioid fibrosarcoma.
  • [MeSH-major] Fibroma / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17255901.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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76. Wolf PS, Flum DR, Tanas MR, Rubin BP, Mann GN: Epithelioid sarcoma: the University of Washington experience. Am J Surg; 2008 Sep;196(3):407-12
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  • [Title] Epithelioid sarcoma: the University of Washington experience.
  • BACKGROUND: Epithelioid sarcoma is a rare sarcoma with a high local recurrence rate that frequently metastasizes to lymph nodes.
  • METHODS: Between 1990 and 2003, we treated 11 patients with epithelioid sarcoma.
  • CONCLUSIONS: Although surgery remains the primary treatment modality, multi-institutional trials are needed to develop more effective adjuvant therapy for patients with epithelioid sarcoma.
  • [MeSH-major] Sarcoma / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Washington

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  • (PMID = 18436180.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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77. Kohashi K, Oda Y, Yamamoto H, Tamiya S, Matono H, Iwamoto Y, Taguchi T, Tsuneyoshi M: Reduced expression of SMARCB1/INI1 protein in synovial sarcoma. Mod Pathol; 2010 Jul;23(7):981-90
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  • [Title] Reduced expression of SMARCB1/INI1 protein in synovial sarcoma.
  • Synovial sarcoma is classified as a tumor of uncertain differentiation, and some synovial sarcomas have rhabdoid cells.
  • In previous studies, all malignant rhabdoid tumors and renal medullary carcinomas, some extraskeletal myxoid chondrosarcomas, almost all epithelioid sarcomas and half of epithelioid malignant peripheral nerve sheath tumors showed a loss of SMARCB1/INI1 protein expression in tumor cells and all of these tumors are also known to have rhabdoid cells.
  • We analyzed the immunohistochemical and mRNA expression of SMARCB1/INI1 in 95 synovial sarcomas (73 monophasic fibrous type, 18 biphasic type and 4 poorly differentiated type) and 30 spindle cell sarcomas (3 adult fibrosarcomas, 7 fibrosarcomas arising in dermatofibrosarcoma protuberans, 10 leiomyosarcomas and 10 malignant peripheral nerve sheath tumors) resembling monophasic fibrous synovial sarcoma.
  • The results have shown that 66 of the 95 synovial sarcoma cases (69%) had reduced SMARCB1/INI1 protein expression, whereas the remaining 29 cases (31%) and all 30 spindle cell sarcomas showed preserved this protein expression.
  • The median values of SMARCB1/INI1 mRNA expression in non-tumor skeletal muscle and synovial sarcoma with reduced protein expression were 12.86 and 134.01, respectively, and a statistically significant difference was detected between these two groups (P=0.0000004).
  • However, there was no statistically significant difference of prognosis between the synovial sarcoma group with reduced and that with preserved SMARCB1/INI1 protein expression (P=0.46).
  • Therefore, it was suggested that there is a post-transcriptional SMARCB1/INI1 regulatory mechanism in the tumor cells of synovial sarcoma.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / biosynthesis. DNA-Binding Proteins / biosynthesis. Sarcoma, Synovial / metabolism. Sarcoma, Synovial / pathology. Soft Tissue Neoplasms / metabolism. Soft Tissue Neoplasms / pathology. Transcription Factors / biosynthesis

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  • (PMID = 20305614.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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78. Piza-Katzer H, Bauer T, Biedermann R, Estermann D: [Heterotopic hand replantation following radical tumor resection in the elbow region. Functional results 15 months after surgery]. Orthopade; 2006 Jul;35(7):791-7
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  • BACKGROUND: In a 28-year-old male who had suffered an olecranon fracture, delayed diagnosis was made of epithelioid sarcoma in the left upper extremity.
  • [MeSH-major] Hand Transplantation. Neoplasms, Connective Tissue / surgery. Reconstructive Surgical Procedures / methods. Recovery of Function. Sarcoma / surgery. Transplantation, Heterotopic / methods. Upper Extremity / surgery
  • [MeSH-minor] Adult. Humans. Male. Treatment Outcome

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  • (PMID = 16586056.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopäde
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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79. Chao KC, Chen C, Hsieh SC, Fang CL, Lao WT, Chan WP: MRI of epithelioid sarcoma of the thigh. Clin Imaging; 2005 Jan-Feb;29(1):60-3
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  • [Title] MRI of epithelioid sarcoma of the thigh.
  • A 31-year-old woman with epithelioid sarcoma of the thigh is presented.
  • Histologic findings were compatible with epithelioid sarcoma.
  • [MeSH-major] Magnetic Resonance Imaging. Sarcoma / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Thigh


80. Vieira Cury SE, Chain Hartung Habibe R, Siroteau Corrêa Pontes F, Rebelo Pontes HA, Santos De Freitas Silva B, Dos Santos Pinto JD: Oral hobnail hemangioma: case report. Minerva Stomatol; 2009 Nov-Dec;58(11-12):613-6
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  • Histological findings showed a biphasic growth pattern of irregularly dilated vascular structures in the superficial mucosa, lined by epithelioid endothelial cells with a hobnail appearance, with neoplastic vessels observed in deeper parts of the lesion.
  • In the oral cavity, the differential diagnosis includes hemangioma, melanoma, and Kaposi's sarcoma, whose clinical and histological features may be confused with those of HH.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lymphangioma / diagnosis. Melanoma / diagnosis. Sarcoma, Kaposi / diagnosis

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  • (PMID = 20027132.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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81. Garuti G, Gonfiantini C, Mirra M, Galli C, Luerti M: Uterine tumor resembling ovarian sex cord tumors treated by resectoscopic surgery. J Minim Invasive Gynecol; 2009 Mar-Apr;16(2):236-40
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  • Histology showed epithelioid cells arranged in nests, cords, tubules, and trabeculae infiltrating the myometrium; no sarcoma cell differentiation was detected.
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Staging

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  • (PMID = 19249718.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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82. Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, Rosenberg AE, Nielsen GP, DeLaney TF, Chen YL, Ott MJ, Yoon SS: Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol; 2009 May;16(5):1356-63
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  • [Title] Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas.
  • BACKGROUND: Soft tissue sarcomas generally have a </=5% risk of lymph node metastasis, but synovial, epithelioid, and clear cell subtypes reportedly have a much higher risk.
  • The utility of sentinel lymph node biopsy (SLNB) for patients with these sarcoma subtypes is unknown.
  • METHODS: 29 patients with nonmetastatic synovial, epithelioid, and clear cell sarcomas who underwent SLNB were examined.
  • The histological subtypes were synovial sarcoma in 16 patients, epithelioid sarcoma in 10, and clear cell sarcoma in 3.
  • CONCLUSION: For patients with these sarcoma subtypes without radiological evidence of nodal or distant metastases, the incidence of occult lymph node metastasis is relatively low.
  • [MeSH-major] Sarcoma / pathology. Sarcoma, Clear Cell / pathology. Sarcoma, Synovial / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Extremities. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Young Adult

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  • (PMID = 19259743.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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83. Nunes LF, Fiod NJ, Vasconcelos RA, Meohas W, Rezende JF: [Epithelioid sarcoma: clinical behavior, prognostic factors and survival]. Rev Col Bras Cir; 2010 Aug;37(4):251-5
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  • [Title] [Epithelioid sarcoma: clinical behavior, prognostic factors and survival].
  • [Transliterated title] Sarcoma epitelióide: aspectos clínicos, fatores prognósticos e sobrevida.
  • OBJECTIVE: To relate the clinical characteristics and evaluations of patients with epithelioid sarcomas.
  • METHODS: Careful analysis of 25 epithelioid sarcoma cases registered in Instituto Nacional do Cancer between june 1987 and july 2005.
  • CONCLUSION: Epithelioid sarcoma is a rare subset of soft tissue sarcoma with high rate of local recurrence, regional node and distant metastases.
  • Surgical treatment of epithelioid sarcoma consists of early wide local resection to negative microscopic margins.
  • [MeSH-major] Sarcoma / diagnosis. Sarcoma / mortality. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Prognosis. Survival Rate. Young Adult

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  • (PMID = 21085839.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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84. Liu Y, Zheng H, Liu Y, Fang K: Metastatic epithelioid sarcoma. Eur J Dermatol; 2007 May-Jun;17(3):249-50
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  • [Title] Metastatic epithelioid sarcoma.
  • [MeSH-major] Lung Neoplasms / secondary. Sarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Ankle / pathology. Epithelioid Cells / pathology. Female. Humans. Skin Ulcer / etiology


85. Bien E, Kazanowska B, Dantonello T, Adamkiewicz-Drozynska E, Balcerska A, Madziara W, Rybczynska A, Nurzynska-Flak J, Solarz E, Kurylak A, Zalewska-Szewczyk B, Krawczyk M, Izycka-Swieszewska E, Rapala M, Koscielniak E: Factors predicting survival in childhood malignant and intermediate vascular tumors : retrospective analysis of the Polish and German cooperative paediatric soft tissue sarcoma study groups and review of the literature. Ann Surg Oncol; 2010 Jul;17(7):1878-89
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  • [Title] Factors predicting survival in childhood malignant and intermediate vascular tumors : retrospective analysis of the Polish and German cooperative paediatric soft tissue sarcoma study groups and review of the literature.
  • METHODS: A total of 32 children with malignant vascular tumors (14 angiosarcomas [AS], 5 epithelioid hemangioendotheliomas, and 13 intermediate vascular tumors, including other hemangioendotheliomas plus adult-type hemangiopericytomas), registered in the German and Polish Paediatric Soft Tissue Sarcomas Study Groups, were treated following the Cooperative Weichteilsarkom Studiengruppe (CWS)-81, -86, -91, and -96 protocols.
  • CONCLUSIONS: The clinical course and outcome in childhood epithelioid HE seems to be similar to intravascular tumors and less aggressive than AS.
  • [MeSH-major] Hemangioendothelioma / mortality. Hemangiopericytoma / mortality. Hemangiosarcoma / mortality. Sarcoma / mortality. Vascular Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Germany / epidemiology. Humans. Infant. Infant, Newborn. Male. Poland / epidemiology. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 20333551.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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86. Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, La Quaglia MP, Fong Y, Brennan MF, Blumgart LH, Dematteo RP: Management of primary liver sarcomas. Cancer; 2007 Apr 1;109(7):1391-6
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  • BACKGROUND: Primary hepatic sarcoma is a rare entity.
  • METHODS: Between January 1981 and December 2004, 30 patients with primary sarcoma of the liver and 5 patients with primary carcinosarcoma of the liver were treated.
  • RESULTS: Of the 30 patients with primary hepatic sarcoma (10 epithelioid hemangioendothelioma, 5 embryonal sarcoma, 5 angiosarcoma, 3 solitary fibrous tumor, and 7 other types), 11 underwent R0-resection and had a 5-year disease-specific survival of 64%.
  • Of these 11 patients, 4 had low-grade sarcoma and have not developed tumor recurrence.
  • In the group of 7 patients with high-grade sarcomas who underwent R0-resection, both patients with angiosarcoma died within 11 months, whereas the 5 patients with embryonal sarcoma had a 5-year disease-free and disease-specific survival of 80%.
  • Six of the 10 patients with an epithelioid hemangioendothelioma were managed without surgery, as they had diffuse, slowly progressing, or stable lesions; these patients had a 5-year disease-specific survival of 67%.
  • CONCLUSIONS: The outcome of patients with primary hepatic sarcoma depends primarily on tumor histology and the ability to achieve complete tumor resection.
  • [MeSH-major] Liver Neoplasms / therapy. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinosarcoma / therapy. Child. Female. Fibrosarcoma / therapy. Hemangioendothelioma, Epithelioid / therapy. Hemangiosarcoma / therapy. Humans. Leiomyosarcoma / therapy. Male. Middle Aged. Prognosis. Prospective Studies. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17315167.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Wang XI, Zhang S, Thomas JO, Adegboyega PA: Cytomorphology, ultrastructural, and cytogenetic findings in follicular dendritic cell sarcoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):759-63
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  • [Title] Cytomorphology, ultrastructural, and cytogenetic findings in follicular dendritic cell sarcoma: a case report.
  • BACKGROUND: Follicular dendritic cell (FDC) sarcoma is a rare low-to-intermediate grade malignant dendritic cell neoplasm that often has an indolent clinical course.
  • Fine needle aspiration cytology revealed many large, spindle to ovoid epithelioid cells in singles, small clusters, and syncytial sheets with moderate to abundant cytoplasm, indistinct cell borders, irregular nuclear membrane, fine to vesicular chromatin, and conspicuous nucleoli.
  • The background contained many small mature lymphocytes intimately mixed with large epithelioid tumor cells.
  • Diagnosis of FDC sarcoma was rendered; follow-up surgical resection and ultrastructural study confirmed the diagnosis.
  • CONCLUSION: Although the cytomorphology of FDC sarcoma is characteristic, a preoperative diagnosis of FDC sarcoma based on fine needle aspiration cytology is very challenging, if not impossible.
  • [MeSH-major] Cytogenetic Analysis. Dendritic Cell Sarcoma, Follicular / genetics. Dendritic Cell Sarcoma, Follicular / pathology. Dendritic Cells, Follicular / pathology. Dendritic Cells, Follicular / ultrastructure
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Cell Proliferation. Desmosomes / ultrastructure. Humans. Neck / pathology

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  • (PMID = 21053535.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Koplin SA, Nielsen GP, Hornicek FJ, Rosenberg AE: Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases. Int J Surg Pathol; 2010 Jun;18(3):207-12
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  • [Title] Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases.
  • Epithelioid sarcoma is an uncommon malignancy that usually arises in the superficial soft tissues of the extremities.
  • Classically, epithelioid sarcoma grows as nodules of mild to moderately atypical epithelioid cells, frequently with central necrosis.
  • The presence of bone within epithelioid sarcoma raises a variety of lesions in the differential diagnosis, including reactive processes as well as benign and malignant neoplasms.This morphological variant of epithelioid sarcoma and its associated diagnostic pitfalls has received little attention in the literature.
  • The authors report herein 4 cases of epithelioid sarcoma with heterotopic bone and highlight the morphological characteristics of the bone and how such variants can be distinguished from other bone-forming lesions of the soft tissues.
  • [MeSH-major] Ossification, Heterotopic / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Child, Preschool. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Humans. Intermediate Filaments / ultrastructure. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20034988.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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89. Ardeleanu C, Comănescu M, Comănescu V, Andrei F: Uncommon pattern in soft tissues epithelioid sarcoma. Rom J Morphol Embryol; 2005;46(3):229-33
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  • [Title] Uncommon pattern in soft tissues epithelioid sarcoma.
  • Epithelioid sarcoma (ES) is a rare tumor, but extremely versatile, simulating easily both clinically and morphologically multiple benign lesions as granulomas and malignant tumors as achromic melanomas or carcinomas.
  • AIM: To report some peculiar histological and immunophenotypic aspects in soft parts epithelioid sarcoma.
  • MATERIALS AND METHODS: We analyzed retrospectively three cases of epithelioid sarcomas with unusual clinico-morphological (large dimensions), histopathological (absence of necrosis) and immunohistochemical (IHC) patterns selected from 200 consecutive soft parts malignant tumors of "Victor Babeş" National Institute Bucharest files.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, CD34 / analysis. Child. Humans. Immunohistochemistry. Middle Aged. Retrospective Studies

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  • (PMID = 16444310.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34
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90. Thomas DG, Giordano TJ, Sanders D, Biermann S, Sondak VK, Trent JC, Yu D, Pollock RE, Baker L: Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma. Cancer; 2005 Feb 15;103(4):830-8
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  • [Title] Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma.
  • BACKGROUND: Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology.
  • METHODS: Archival specimens of synovial sarcoma (n=38) representing 30 patients were assessed for EGFR and HER-2/neu protein expression by standard immunohistochemical techniques.
  • [MeSH-major] Oncogene Proteins, Fusion / genetics. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis. Sarcoma, Synovial / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Gene Amplification. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. RNA, Messenger / analysis. Receptor Protein-Tyrosine Kinases / genetics. Receptor Protein-Tyrosine Kinases / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 15641030.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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91. Fujisawa Y, Takahashi T, Enomoto H, Nakamura Y, Kawachi Y, Otsuka F: A case of proximal-type epithelioid sarcoma which showed positive reactivity to fibroblast growth factor receptor 2-IIIb isotype. J Eur Acad Dermatol Venereol; 2008 Nov;22(11):1372-3
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  • [Title] A case of proximal-type epithelioid sarcoma which showed positive reactivity to fibroblast growth factor receptor 2-IIIb isotype.
  • [MeSH-major] Receptor, Fibroblast Growth Factor, Type 2 / metabolism. Sarcoma / metabolism
  • [MeSH-minor] Adult. Alternative Splicing. Female. Humans. RNA, Messenger / genetics

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  • (PMID = 18482307.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.10.1 / FGFR2 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 2
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92. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
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  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Nearly all tumors had a lobulated or micronodular architecture and were composed of nests and bundles of epithelioid to spindled cells with palely eosinophilic cytoplasm, often separated by dense hyaline collagen; 17 (13%) showed focally sheetlike areas, and 5 (4%) were notably plexiform.
  • Cellular neurothekeomas have a predilection for the upper limbs and head and neck of pediatric and young adult females and rarely recur following incomplete excision.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

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  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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93. Hansen T, Katenkamp K, Brodhun M, Katenkamp D: Low-grade fibrosarcoma--report on 39 not otherwise specified cases and comparison with defined low-grade fibrosarcoma types. Histopathology; 2006 Aug;49(2):152-60
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  • Among these, low-grade fibromyxoid sarcoma (FMS), hyalinizing spindle cell tumour with giant collagen rosettes (HST) and sclerosing epithelioid fibrosarcoma (SEF) are well-established entities.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Microscopy, Electron. Middle Aged. Neoplasm Recurrence, Local. Terminology as Topic

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  • (PMID = 16879392.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Ki-67 Antigen
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94. Reis C, Carneiro E, Fonseca J, Pereira P, Vaz R, Pinto R, Capelinha AF, Lopes JM, Salgado A: Epithelioid hemangioendothelioma and multiple thoraco-lumbar lateral meningoceles: two rare pathological entities in a patient with NF-1. Neuroradiology; 2005 Feb;47(2):165-9
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  • [Title] Epithelioid hemangioendothelioma and multiple thoraco-lumbar lateral meningoceles: two rare pathological entities in a patient with NF-1.
  • Epithelioid hemangioendothelioma (EHE) is a rare vascular soft-tissue tumour of intermediate malignancy.
  • Neurofibromatosis type I (NF-1) is a genetic syndrome associated with soft tissue sarcoma and higher risk of developing neoplasia.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / etiology. Meningocele / etiology. Neurofibromatosis 1 / complications. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Lumbar Vertebrae. Radiography. Thoracic Vertebrae

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  • (PMID = 15688204.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
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95. Eyden B, Wang G, Yao L: Epithelioid sarcoma: a case report with ultrastructural confirmation of myofibroblastic differentiation based on fibronexus junctions. Ultrastruct Pathol; 2009 Mar-Apr;33(2):61-6
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  • [Title] Epithelioid sarcoma: a case report with ultrastructural confirmation of myofibroblastic differentiation based on fibronexus junctions.
  • Epithelioid sarcoma is an uncommon but well-described malignancy, which is found predominantly in the soft tissues of the young and middle-aged, and which pursues an indolent to aggressive course.
  • Myofibroblastic differentiation has been recorded in epithelioid sarcoma for some time, the evidence being based mainly on the presence of smooth-muscle-type myofilaments and, more recently, on alpha-smooth-muscle actin and muscle-specific actin immunostaining.
  • The authors describe a conventional epithelioid sarcoma showing myofibroblastic differentiation based on the presence of fibronectin fibrils and fibronexus junctions.
  • Histologically, the tumors had the typical features of epithelioid sarcoma: by immunohistochemistry, cytokeratin, epithelial membrane antigen, and vimentin were positive.
  • This is the first epithelioid sarcoma of conventional histological type to show myofibroblastic differentiation on the basis of the more stringent criterion of the fibronexus.
  • [MeSH-major] Cell Transformation, Neoplastic / ultrastructure. Fibroblasts / ultrastructure. Intercellular Junctions / ultrastructure. Muscle Fibers, Skeletal / ultrastructure. Sarcoma / ultrastructure. Soft Tissue Neoplasms / ultrastructure
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasm / ultrastructure. Fibronectins / ultrastructure. Fingers / pathology. Fingers / surgery. Humans. Male. Microscopy, Electron, Transmission / methods. Neoplasm Recurrence, Local

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  • (PMID = 19274582.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fibronectins
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96. Akiyama T, Hamazaki S, Monobe Y, Nishimura H, Irei I, Sadahira Y: Sphingosine-1-phosphate receptor 1 is a useful adjunct for distinguishing vascular neoplasms from morphological mimics. Virchows Arch; 2009 Feb;454(2):217-22
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  • S1P(1) expression was observed in eight of eight hemangiomas, four of four lymphangiomas, four of four epithelioid hemangioendotheliomas, three of three Kaposi's sarcomas, and 15 of 15 angiosarcomas with vasoformative, spindle, epithelioid, and undifferentiated features.
  • Conventional analysis and use of a tissue microarray of soft tissue tumors revealed three of 21 liposarcomas to have weak cytoplasmic staining and one of five squamous cell carcinomas to have membranous staining in a very limited area among 115 nonvascular tumors including histological mimics of angiosarcoma such as undifferentiated carcinoma, melanoma, and epithelioid sarcoma.
  • [MeSH-minor] Adult. Aged. Female. Hemangioma / diagnosis. Hemangiosarcoma / diagnosis. Humans. Immunohistochemistry. Lymphangioma / diagnosis. Male. Middle Aged

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  • (PMID = 19005676.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Lysosphingolipid
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97. Pai KK, Pai SB, Sripathi H, Pranab, Rao P: Epithelioid sarcoma: a diagnostic challenge. Indian J Dermatol Venereol Leprol; 2006 Nov-Dec;72(6):446-8
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  • [Title] Epithelioid sarcoma: a diagnostic challenge.
  • Epithelioid sarcoma is an uncommon slow-growing soft tissue malignancy, associated with a high incidence of local recurrence and metastasis.
  • We report a 26-year-old male with epithelioid sarcoma on the right palm with a long history of over seven years, which was initially misdiagnosed as cutaneous tuberculosis and epithelioid hemangioendothelioma, as a result of which the treatment was delayed.
  • [MeSH-major] Hand. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Dermis / pathology. Diagnosis, Differential. Epidermis / pathology. Hemangioendothelioma, Epithelioid / pathology. Humans. Male

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  • (PMID = 17179622.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 8
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98. Craddock KJ, Labonte S, Ghazarian D: Anaplastic Kaposi sarcoma resembling epithelioid angiosarcoma in an HIV-positive man. Eur J Dermatol; 2008 May-Jun;18(3):358-9
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  • [Title] Anaplastic Kaposi sarcoma resembling epithelioid angiosarcoma in an HIV-positive man.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. HIV Infections / complications. Hemangiosarcoma / diagnosis. Herpesvirus 8, Human. Sarcoma, Kaposi / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Nuclear Proteins / metabolism. Phosphoproteins / metabolism. Skin / pathology


99. Talbot SG, Mehrara BJ, Disa JJ, Wong AK, Pusic A, Cordeiro PG, Athanasian EA: Soft-tissue coverage of the hand following sarcoma resection. Plast Reconstr Surg; 2008 Feb;121(2):534-43
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  • [Title] Soft-tissue coverage of the hand following sarcoma resection.
  • The authors review the experience at a single institution of hand reconstruction following sarcoma resection based on prospectively collected data.
  • METHODS: Data were collected for all patients undergoing sarcoma resection by a single surgeon.
  • The most common abnormalities were epithelioid sarcoma (n = 9), soft-tissue malignant fibrous histiocytoma (n = 8), synovial sarcoma (n = 6), and fibrosarcoma (n = 4).
  • CONCLUSIONS: The choice of hand reconstruction method following sarcoma resection depends on a complete knowledge of options, risks, and benefits.
  • [MeSH-major] Hand. Reconstructive Surgical Procedures / methods. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Amputation / methods. Biopsy. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Retrospective Studies. Surgical Flaps. Survival Rate. Treatment Outcome. United States / epidemiology


100. Wan Musa WR, Abdulwakil Elraied MA, Phang KS, Kwah YG, Tan SP, Harun R, Ban AY: Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain. Ann Acad Med Singapore; 2010 Aug;39(8):658-9
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  • [Title] Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain.
  • [MeSH-major] Hemangiosarcoma / complications. Lung Neoplasms / complications. Sarcoma / complications. Shoulder Pain / diagnosis
  • [MeSH-minor] Humans. Male. Young Adult

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  • (PMID = 20838710.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Singapore
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