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1. Lal A, Mumtaz HA, Radhika S, Khandelwal N: Endodermal sinus tumor: a rare cause of calcified peritoneal implants. Cancer Imaging; 2009;9:29-31
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  • [Title] Endodermal sinus tumor: a rare cause of calcified peritoneal implants.
  • Histopathology showed an endodermal sinus tumor, a rare cause of calcified peritoneal carcinomatosis.
  • [MeSH-major] Endodermal Sinus Tumor / radiography. Endodermal Sinus Tumor / secondary. Peritoneal Neoplasms / radiography. Peritoneal Neoplasms / secondary. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Calcinosis. Female. Humans. Ovarian Neoplasms / pathology

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  • (PMID = 19602468.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 14
  • [Other-IDs] NLM/ PMC2739686
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2. Matsunaga S, Fujitsu K, Yagishita S, Ichikawa T, Takemoto Y, Takeda Y, Miyahara K, Niino H, Shiina T: Endodermal cyst ventral to the lower brain stem. Neurol Med Chir (Tokyo); 2006 Dec;46(12):614-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endodermal cyst ventral to the lower brain stem.
  • A 28-year-old woman presented with a rare case of endodermal cyst located ventral to the lower brain stem manifesting as recurrent aseptic meningitis.
  • The histological diagnosis was endodermal cyst.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Endodermal Sinus Tumor / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 17185890.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Sada E, Shiratsuchi M, Kiyasu J, Idutsu K, Ohtsuka R, Nagasawa E, Karube K, Takayanagi R, Abe Y: Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome. J Clin Exp Hematop; 2009 Nov;49(2):117-20
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  • [Title] Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome.
  • A 20-year-old man with a primary non-seminomatous mediastinal germ cell tumor (yolk sac tumor and immature teratoma) developed hemophagocytic syndrome (HPS) three months after surgical resection.
  • Around the same time, the patient was found to have bone metastases of the germ cell tumor.
  • The thrombocytopenia was refractory to corticosteroid therapy but improved after chemotherapy performed for germ cell tumor progression.
  • Only three cases of germ cell tumor associated with reactive hemophagocytosis have been previously reported.
  • Successful treatment of the present case by chemotherapy for HPS suggests a close relationship between this rare complication and germ cell tumor.
  • [MeSH-major] Endodermal Sinus Tumor / therapy. Lymphohistiocytosis, Hemophagocytic / therapy. Mediastinal Neoplasms / therapy. Teratoma / therapy
  • [MeSH-minor] Adult. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Humans. Male. Neoplasm Metastasis. Remission Induction

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  • (PMID = 19907116.001).
  • [ISSN] 1880-9952
  • [Journal-full-title] Journal of clinical and experimental hematopathology : JCEH
  • [ISO-abbreviation] J Clin Exp Hematop
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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4. Klieger C, Dvir R, Even-Sapir E, Lessing JB, Burstein Y, Grisaru D: Integrated 18F-fluorodeoxyglucose positron emission tomography and computerized tomography in endodermal sinus tumor. Int J Gynecol Cancer; 2006 Jul-Aug;16(4):1685-8
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  • [Title] Integrated 18F-fluorodeoxyglucose positron emission tomography and computerized tomography in endodermal sinus tumor.
  • Application of an in-line positron emission tomography and computerized tomography (PET-CT) in endodermal sinus tumor (EST) is described in this study.
  • Follow-up PET-CT was negative in keeping with no viable tumor tissue.
  • EST is an FDG-avid tumor.
  • PET-CT delineated the prechemotherapy tumor extent adequately ruled out the presence of residual tumor after a successful treatment.
  • [MeSH-major] Endodermal Sinus Tumor / radionuclide imaging. Fluorodeoxyglucose F18. Positron-Emission Tomography. Radiopharmaceuticals
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Neoplasm Staging. Prognosis. alpha-Fetoproteins / metabolism

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  • (PMID = 16884385.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / alpha-Fetoproteins; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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5. Ayhan A, Taskiran C, Bozdag G, Altinbas S, Altinbas A, Yuce K: Endodermal sinus tumor of the ovary: the Hacettepe University experience. Eur J Obstet Gynecol Reprod Biol; 2005 Dec 1;123(2):230-4
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  • [Title] Endodermal sinus tumor of the ovary: the Hacettepe University experience.
  • OBJECTIVE: The purpose of this study was to evaluate the treatment regimens used for patients with endodermal sinus tumors (EST), and also to examine the prognostic value of surgicopathological variables.
  • There was no significant survival difference with respect to age, histology, and tumor size.
  • [MeSH-major] Endodermal Sinus Tumor / therapy. Ovarian Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Child. Combined Modality Therapy. Female. Gynecologic Surgical Procedures. Hospitals, University. Humans. Middle Aged. Neoplasm Staging. Platinum Compounds / therapeutic use. Prognosis. Retrospective Studies. Survival Analysis. Turkey

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  • (PMID = 16026921.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Platinum Compounds
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6. Gupta R, Mathur SR, Arora VK, Sharma SG: Cytologic features of extragonadal germ cell tumors: a study of 88 cases with aspiration cytology. Cancer; 2008 Dec 25;114(6):504-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Seminomas had dyscohesive tumor cells with well defined, vacuolated cytoplasm; prominent nucleolus; and background lymphocytes.
  • Yolk sac tumors revealed papillary fragments of tumor cells with metachromatic basement membrane-like material in the fragments.
  • CONCLUSIONS: Fine-needle aspiration cytology can reliably offer a diagnosis of GCT at extragonadal sites, even in rare locations and in patients in whom metastatic tumor may be the first clinical presentation.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Endodermal Sinus Tumor / pathology. Female. Humans. Infant. Male. Middle Aged. Retrospective Studies. Seminoma / pathology. Teratoma / pathology

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18980289.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Furukawa S, Haruta M, Arai Y, Honda S, Ohshima J, Sugawara W, Kageyama Y, Higashi Y, Nishida K, Tsunematsu Y, Nakadate H, Ishii M, Kaneko Y: Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes. Cancer Sci; 2009 Apr;100(4):698-708
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  • [Title] Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes.
  • Previous studies suggested that GCTs show epigenetic patterns reflecting the reprogramming process of PGCs; however, epigenetic alterations of imprinted genes and their relationship with the methylation status of tumor suppressor genes (TSGs) have not been comprehensively studied.
  • We analyzed the methylation status of the H19 and SNRPN differential methylated regions (DMRs) and the promoter region of 17 TSGs, and the expression status of H19, IGF2 and SNRPN in 45 GCTs, and found that 25 and 20 were in the normal and abnormal reprogramming pathways, respectively, defined on the basis of the methylation status of the two DMRs and the anatomical tumor site.
  • The methylation pattern of the H19 and SNRPN DMRs was total erasure in seminomas, mostly physiological in teratomas, and various in yolk sac tumors.
  • Furthermore, we found that yolk sac tumors had a higher number of methylated TSGs than seminomas (P < 0.001) teratomas (P = 0.004) or other childhood tumors.
  • While TSG methylation was known to have prognostic implications in various cancers, it did not affect the outcomes of patients with yolk sac tumor, suggesting that mechanisms of TSG methylation may be different between yolk sac tumor and other cancers.
  • [MeSH-major] DNA Methylation. Endodermal Sinus Tumor / genetics. Epigenesis, Genetic. Genes, Tumor Suppressor. Seminoma / genetics. Teratoma / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Genomic Imprinting. Humans. Infant. Infant, Newborn. Male. Models, Genetic. Promoter Regions, Genetic. Young Adult

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  • (PMID = 19245437.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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8. Zhang B, Gao S, Chen Y, Wu Y: Primary yolk sac tumor arising in the pancreas with hepatic metastasis: a case report. Korean J Radiol; 2010 Jul-Aug;11(4):472-5
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  • [Title] Primary yolk sac tumor arising in the pancreas with hepatic metastasis: a case report.
  • Extragonadal yolk sac tumor (YST) is a relatively rare entity.
  • We describe here the case of an extragonadal YST that occurred in the pancreas with hepatic metastasis in an adult woman.
  • [MeSH-major] Endodermal Sinus Tumor / radiography. Liver Neoplasms / radiography. Pancreatic Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 20592932.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC2893319
  • [Keywords] NOTNLM ; Computed tomography (CT) / Diagnosis / Pancreas / Yolk sac tumor
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9. Basgul A, Gokaslan H, Kavak ZN, Eren FT, Bozkurt N: Primary yolk sac tumor (endodermal sinus tumor) of the vulva: case report and review of the literature. Eur J Gynaecol Oncol; 2006;27(4):395-8
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  • [Title] Primary yolk sac tumor (endodermal sinus tumor) of the vulva: case report and review of the literature.
  • INTRODUCTION: Endodermal sinus tumor (EST) or primary yolk sac tumor (YST) of the vulva is extremely rare and a highly malignant germ cell tumor.
  • We present the tenth case of endodermal sinus tumor of the vulva.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans

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  • (PMID = 17009634.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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10. Thanaboonyawat I, Benjapibal M: A case of ovarian endodermal sinus tumor diagnosed during pregnancy. J Med Assoc Thai; 2008 May;91(5):764-8
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  • [Title] A case of ovarian endodermal sinus tumor diagnosed during pregnancy.
  • Pregnancy complicated by endodermal sinus tumor of the ovary is extremely rare.
  • The authors present a case report of a pregnant woman with persistent left adnexal mass and subsequently found to have a primary endodermal sinus tumor of the ovary that was diagnosed at 19 weeks of gestation.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Abortion, Induced. Adult. Antibiotics, Antineoplastic / adverse effects. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Phytogenic / adverse effects. Antineoplastic Agents, Phytogenic / therapeutic use. Bleomycin / adverse effects. Bleomycin / therapeutic use. Cisplatin / adverse effects. Cisplatin / therapeutic use. Etoposide / adverse effects. Etoposide / therapeutic use. Fatal Outcome. Female. Humans. Ovariectomy / methods. Pregnancy. Pregnancy Trimester, First. Pulmonary Fibrosis / chemically induced

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  • (PMID = 18672645.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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11. Robova H, Rob L, Hrehorcak M, Zoban P, Prusa R: Endodermal sinus tumor diagnosed in pregnancy: a case report. Int J Gynecol Cancer; 2007 Jul-Aug;17(4):914-6
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  • [Title] Endodermal sinus tumor diagnosed in pregnancy: a case report.
  • Pure endodermal sinus tumor (EST) of the ovary is an uncommon germ cell tumor characterized by rapid growth.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / therapy. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / therapy. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Female. Humans. Infant, Newborn. Pregnancy

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  • (PMID = 17635618.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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12. Kang H, Kim TJ, Kim WY, Choi CH, Lee JW, Kim BG, Bae DS: Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. Gynecol Oncol; 2008 Oct;111(1):106-10
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  • [Title] Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor.
  • OBJECTIVE: The aim of this study was to investigate the outcome and reproductive function of patients with ovarian endodermal sinus tumor (EST) after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP).
  • Among these patients, 51 had a confirmed diagnosis of malignant ovarian germ cell tumor (MOGCT) including 20 cases of EST.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / physiopathology. Fertility. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / physiopathology. Ovary / physiopathology
  • [MeSH-minor] Adolescent. Adult. Bleomycin / administration & dosage. Bleomycin / adverse effects. Chemotherapy, Adjuvant. Child. Child, Preschool. Cisplatin / administration & dosage. Cisplatin / adverse effects. Dose-Response Relationship, Drug. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Gynecologic Surgical Procedures / methods. Humans. Retrospective Studies. Treatment Outcome

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  • (PMID = 18656249.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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13. Ayas S, Aköz I, Eskicirak E, Karateke A, Bozoklu O: A case of endodermal sinus tumor associated with the first pregnancy and successful management of the second pregnancy: a case report and review of the literature. Eur J Gynaecol Oncol; 2007;28(2):155-9
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  • [Title] A case of endodermal sinus tumor associated with the first pregnancy and successful management of the second pregnancy: a case report and review of the literature.
  • BACKGROUND: Pregnancy complicated by endodermal sinus tumor (EST) of the ovary has rarely been reported.
  • Abnormally high alpha-fetoprotein (AFP) levels suggested a malignant germ cell tumor of the ovary.
  • CONCLUSIONS: Successful outcome of a second pregnancy is possible after treatment with fertility sparing surgery and combination chemotherapy for an endodermal sinus tumor associated with a first pregnancy.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / drug therapy. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / drug therapy. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Pregnancy. Pregnancy Outcome. Pregnancy Trimester, Third. Treatment Outcome. alpha-Fetoproteins / analysis

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  • (PMID = 17479685.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
  • [Number-of-references] 34
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14. Nogales FF, Buriticá C, Regauer S, González T: Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors. Am J Surg Pathol; 2005 Sep;29(9):1247-51
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  • [Title] Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors.
  • We present, for the first time, two yolk sac tumors (YST) in women 37 and 18 years of age, one with a typical parietovisceral pattern and the other with a glandular pattern, which were associated with extensive areas of mucinous carcinoid (MC).
  • The tumor in the first case had numerous nodules of tubulopapillary YST that merged with well-differentiated MC.
  • The tumor in the second case consisted of an AFP-positive glandular YST, with a glandulopapillary pattern closely resembling fetal lung type adenocarcinoma, coexisting with an AFP-negative, cytokeratin 20-positive, atypical MC; transitional areas between the two components were also seen.
  • We think that, in these cases, MC represented an unusual form of endodermal differentiation of the YST.
  • It is important to differentiate the yolk sac and carcinoid components due to their different responses to chemotherapy and to evaluate the possibility of mucinous carcinoid developing into a highly aggressive carcinoma.
  • [MeSH-major] Carcinoid Tumor / pathology. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Female. Humans. Immunohistochemistry. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis. Treatment Outcome. alpha-Fetoproteins / metabolism

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  • (PMID = 16096416.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / alpha-Fetoproteins
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15. Motegi M, Takakura S, Takano H, Tanaka T, Ochiai K: Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary. Obstet Gynecol; 2007 Feb;109(2 Pt2):537-40
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  • [Title] Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary.
  • We describe a case of malignant ovarian tumor complicating pregnancy.
  • A normal infant was delivered, and no evidence of tumor recurrence was observed.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Prenatal Diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cesarean Section. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Infant, Newborn. Pregnancy. Pregnancy Trimester, Third. Prenatal Care. Vinblastine / administration & dosage

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  • (PMID = 17267887.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 25
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16. Shim KW, Kim DS, Choi JU: Mixed or metachronous germ-cell tumor? Childs Nerv Syst; 2007 Jun;23(6):713-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed or metachronous germ-cell tumor?
  • OBJECTIVE AND IMPORTANCE: We report the extremely rare occurrence of a second germ-cell tumor at a different site and with different histological types long after total resolution of a pineal germinoma.
  • Neuroradiological studies revealed a tumor in the pineal region.
  • The tumor was biopsied with endoscope, and third ventriculostomy was performed.
  • Histologically, the tumor proved to be a germinoma.
  • The tumor was totally resolute.
  • Neuroradiological studies showed a tumor in the right temporal lobe.
  • INTERVENTION: The second tumor was totally removed.
  • Histologically, the tumor proved to be a mixed germ-cell tumor, which consisted a yolk-sac tumor and a germinoma.
  • After the second course of chemotherapy, magnetic resonance image studies revealed no evidence of the tumor.
  • CONCLUSION: The second tumor was considered to be a metachronous neoplasm rather than a recurrence of the original mixed germ-cell tumor, which consisted a yolk-sac tumor and a germinoma.
  • [MeSH-major] Brain Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Germinoma / pathology. Neoplasms, Multiple Primary / pathology. Pinealoma / pathology. Temporal Lobe / pathology
  • [MeSH-minor] Adult. Humans. Male. Ventriculostomy

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  • (PMID = 17187270.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Erdemoglu E, Ozen S: Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report. Eur J Gynaecol Oncol; 2007;28(6):516-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report.
  • This is the first case report of a pure endodermal sinus tumor of the ovary with gonodoblastoma in a 46 XX, female.
  • Fertility sparing surgery was undertaken and revealed a Stage IA endodermal sinus tumor and gonodoblastoma in the same ovary.
  • Tumor markers and immunohistochemical examination may help in the diagnosis of these OGCTs with gonodoblastoma.
  • [MeSH-major] Endodermal Sinus Tumor / genetics. Gonadoblastoma / genetics. Ovarian Neoplasms / genetics
  • [MeSH-minor] Adult. Female. Humans. Karyotyping

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  • (PMID = 18179152.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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18. Hirashiki K, Kishimoto T, Ishiguro H, Nagai Y, Furuya M, Sekiya S, Ishikura H: Regulatory role of CCAAT/enhancer binding protein-beta in the production of plasma proteins in yolk sac tumor. Exp Mol Pathol; 2005 Jun;78(3):247-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regulatory role of CCAAT/enhancer binding protein-beta in the production of plasma proteins in yolk sac tumor.
  • Yolk sac tumor (endodermal sinus tumor) is a malignant germ cell tumor characterized by AFP production, in which histologic foci similar to hepatocellular carcinoma occasionally coexist.
  • We assumed a possible contribution of CCAAT/enhancer binding protein (C/EBP)-beta, a transcription factor implicated in the regulation of plasma proteins in the liver, to the regulation of AFP production and to the expression of other plasma proteins in yolk sac tumor cells because our immunohistochemical analysis revealed nuclear expression of C/EBP-beta in human yolk sac tumors.
  • Overexpression of C/EBP-beta in a rat yolk sac tumor cell line, AT-2-TC, increased production of AFP and other plasma proteins, including albumin, alpha-1-antitrypsin, hepatoglobin, and transferrin.
  • These results indicate that C/EBP-beta plays a role in the production of plasma proteins of yolk sac tumors.
  • [MeSH-major] Blood Proteins / biosynthesis. CCAAT-Enhancer-Binding Protein-beta / metabolism. Endodermal Sinus Tumor / metabolism
  • [MeSH-minor] Adult. Animals. Blotting, Western. Cell Line, Tumor. Humans. Immunohistochemistry. Male. Phosphorylation. Protein Isoforms / metabolism. Rats. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors / metabolism. Transfection

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  • (PMID = 15924879.001).
  • [ISSN] 0014-4800
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / CCAAT-Enhancer-Binding Protein-beta; 0 / Protein Isoforms; 0 / Transcription Factors
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19. Al-Agha OM, Axiotis CA: An in-depth look at Leydig cell tumor of the testis. Arch Pathol Lab Med; 2007 Feb;131(2):311-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An in-depth look at Leydig cell tumor of the testis.
  • Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium.
  • The tumor is usually benign, but malignant variants can occur.
  • The pathologic diagnosis of LCT is usually made based on morphologic characteristics of the tumor cells.
  • Pathologists have to be familiar with the diagnostic histopathologic features, immunohistochemical panel of this tumor, and its principal differential diagnoses to prevent tumor misdiagnosis.
  • [MeSH-major] Leydig Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Sarcoma / pathology

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  • (PMID = 17284120.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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20. Wang W, Gong ZH, Dai YT: [Value of ultrasonography in the diagnosis and differential diagnosis of testicular tumor]. Zhonghua Nan Ke Xue; 2007 May;13(5):424-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of ultrasonography in the diagnosis and differential diagnosis of testicular tumor].
  • OBJECTIVE: To evaluate ultrasonography in the diagnosis and differential diagnosis of testicular tumor.
  • RESULTS: Of the total number, 50 cases were testicular hematoma, 13 testicular cyst, 26 testicular inflammatory node, 25 testicular tuberculosis and 58 testicular tumor.
  • Among 59 testicular tumor cases, 50 were germ cell tumor (including 41 cases of seminoma and 9 cases of nonseminoma germ cell tumor), 6 were non-germ cell tumor and 3 were secondary tumor.
  • The sonographic features of typical seminoma, teratomas, epidemic cyst, interstitial cell tumor and malignant lymphoma were obvious.
  • CONCLUSION: Ultrasonography, contributive to the preliminary diagnosis and differential diagnosis of testicular tumor and capable of evidence for further treatment, can be the first choice in medical imaging for the diagnosis of testicular tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / ultrasonography. Hematoma / ultrasonography. Humans. Male. Middle Aged. Retrospective Studies. Teratoma / ultrasonography. Testicular Diseases / surgery

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  • (PMID = 17569259.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Avasthi R, Chaudhary SC, Mohanty D, Mishra K: Testicular mixed germ cell tumor metastasizing to heart. J Assoc Physicians India; 2008 Oct;56:812-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular mixed germ cell tumor metastasizing to heart.
  • In view of this a possibility of metastasis secondary to a malignant testicular tumor was considered.
  • The histopathology revealed testicular mixed germ cell tumor (MGCT).
  • [MeSH-minor] Adult. Echocardiography. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / secondary. Fatal Outcome. Humans. Male. Orchiectomy. Tomography, X-Ray Computed

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  • (PMID = 19263711.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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22. Shibata K, Kajiyama H, Yamamoto E, Terauchi M, Ino K, Nawa A, Kikkawa F: Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development. Oncology; 2008;74(1-2):104-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development.
  • OBJECTIVE: Ovarian yolk sac tumor (YST) is rare and highly malignant.
  • [MeSH-major] Cell Line, Tumor. Endodermal Sinus Tumor / genetics. Endodermal Sinus Tumor / pathology. Homeodomain Proteins / physiology. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology. Transcription Factors / physiology
  • [MeSH-minor] Adult. Animals. Female. Humans. Mice. Mice, Nude. RNA, Small Interfering. Transplantation, Heterologous

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18547965.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / NKX2-5 protein, human; 0 / RNA, Small Interfering; 0 / Transcription Factors
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23. Chen CH, Chen TC, Huang WC, Chen TY, Liu HC: An unusual successfully treated case of pulmonary yolk sac tumor. Ann Thorac Surg; 2008 Feb;85(2):656-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual successfully treated case of pulmonary yolk sac tumor.
  • Extragonadal germ cell tumors are relatively rare, particularly malignant yolk sac tumors arising in the lung parenchyma.
  • We report a case of a huge malignant yolk sac tumor in the right middle lobe.
  • The patient was successfully treated with neoadjuvant chemotherapy followed by complete resection of the tumor.
  • [MeSH-major] Endodermal Sinus Tumor / surgery. Lung Neoplasms / surgery. Neoadjuvant Therapy. Pneumonectomy / methods
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neoplasm Staging. Risk Assessment. Thoracotomy / methods. Treatment Outcome

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  • (PMID = 18222293.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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24. Guzel A, Tatli M, Belen D, Seckin H: Spinal cord compression of primary extragonadal giant yolk sac tumor. Spinal Cord; 2007 Mar;45(3):254-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord compression of primary extragonadal giant yolk sac tumor.
  • OBJECTIVE: To report an adult male patient with a primary extragonadal giant yolk sac tumor presenting with acute spinal cord compression.
  • Posteriorly, the third lumbar vertebral body was destructed and the tumor was compressing the dural sac.
  • Pathological diagnosis was a yolk sac tumor.
  • CONCLUSION: Yolk sac tumor should be considered in young adult male patients presenting with acute paraparesis even without any signs or medical history of a testis tumor.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery. Spinal Cord Compression / surgery
  • [MeSH-minor] Adult. Decompression, Surgical. Humans. Lumbosacral Region / pathology. Lumbosacral Region / surgery. Magnetic Resonance Imaging. Male. Paraparesis / etiology. Tomography, X-Ray Computed

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  • (PMID = 16733519.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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25. Umezu T, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Kikkawa F: Long-term outcome and prognostic factors for yolk sac tumor of the ovary. Nagoya J Med Sci; 2008 Mar;70(1-2):29-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcome and prognostic factors for yolk sac tumor of the ovary.
  • Yolk sac tumors of the ovary (YST) are rare and highly malignant tumors occurring in children and young adults.
  • Those with an ascites volume of less than 100 ml or a residual tumor measuring less than 1 cm had improved to a relatively good prognosis.
  • In conclusion, the FIGO (International Federation of Gynecology and Obstetrics) stage, ascites volume and residual tumor size tended to affect the prognosis of YST.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Animals. Child. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Neoplasm Staging. Prognosis. Registries / statistics & numerical data. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 18807293.001).
  • [ISSN] 0027-7622
  • [Journal-full-title] Nagoya journal of medical science
  • [ISO-abbreviation] Nagoya J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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26. Pasternack T, Shaco-Levy R, Wiznitzer A, Piura B: Extraovarian pelvic yolk sac tumor: case report and review of published work. J Obstet Gynaecol Res; 2008 Aug;34(4 Pt 2):739-44
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  • [Title] Extraovarian pelvic yolk sac tumor: case report and review of published work.
  • Extraovarian pelvic yolk sac tumors are rare, with only nine cases documented previously in the published work.
  • We report a case of extraovarian pelvic yolk sac tumor occurring synchronously with breast carcinoma.
  • The patient underwent resection of the pelvic tumor and hepatic implant, omentectomy and breast lumpectomy with sentinel axillary lymph node biopsy.
  • Postoperative adjuvant therapy for the yolk sac tumor included three cycles of the bleomycin, etoposide and cisplatin (BEP) regimen.
  • It is concluded that in women with extraovarian pelvic yolk sac tumor who wish to preserve childbearing capacity, fertility-saving surgery followed by fertility-preserving cisplatin-based chemotherapy is adequate and appropriate treatment.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Endodermal Sinus Tumor / pathology. Neoplasms, Multiple Primary / pathology. Pelvic Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18840194.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 10
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27. Bayar GR, Gulses A, Sencimen M, Aydintug YS, Arpaci F, Gunhan O: Oral metastasis of the mediastinal germ cell tumor (yolk sac). J Craniofac Surg; 2010 Nov;21(6):1828-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral metastasis of the mediastinal germ cell tumor (yolk sac).
  • A yolk sac tumor is a rare malignant tumor of germ cell origin.
  • Yolk sac tumors are malignant, tend to recur locally, and may present with widespread metastases at the time of diagnosis.
  • In this study, we present the case of a 23-year-old man presenting with mandibular and adjacent gingival metastasis of a mediasatinal yolk sac tumor.
  • In this case report, clinical and histopathologic features of the oral metastases of a yolk sac tumor were briefly discussed.
  • [MeSH-major] Endodermal Sinus Tumor / secondary. Gingival Neoplasms / secondary. Mandibular Neoplasms / secondary. Mediastinal Neoplasms / pathology
  • [MeSH-minor] Humans. Lung Neoplasms / secondary. Male. Masseter Muscle / pathology. Muscle Neoplasms / secondary. Skull Neoplasms / secondary. Temporal Bone / pathology. Young Adult

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  • (PMID = 21119432.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Ghaemmaghami F, Ayatollahi H, Daneshbodi B, Azmoodeh FA: Unusual location of ovarian mixed germ cell tumor. Int J Gynecol Cancer; 2005 Sep-Oct;15(5):979-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual location of ovarian mixed germ cell tumor.
  • Intra-abdominal unusual location of mixed germ cell tumor of ovary, which consisted of endodermal sinus tumor and immature teratoma components, has been reported.
  • Laparotomy was performed, and due to specific localization, in which tumor localized as a tumoral bridge between two ovaries, we just performed maximal fertility-sparing surgery by preserving ovaries, tubes, and uterus.
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 16174255.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. May M, Finkbeiner Y, Gunia S, Seehafer M, Knörig J, Hetzer R: Metastasizing testicular germ-cell tumor with infiltration of the right heart: indication for primary metastasectomy. Heart Vessels; 2006 Jan;21(1):63-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing testicular germ-cell tumor with infiltration of the right heart: indication for primary metastasectomy.
  • The case of a 42-year-old male patient with a testicular germ cell tumor extending into the superior caval vein, the left brachiocephalic vein, and the right heart, which manifested as a mild form of pulmonary embolization, is presented.
  • Due to the perceived high risk of continuous embolization and the urgent need to begin systemic chemotherapy, a complete cardiac tumor resection was performed, utilizing a cardiopulmonary bypass, followed by a simultaneous orchiectomy.
  • Histology revealed a 61-cm long vascular tumor as a metastasis of a yolk sac tumor originating from the left testis.
  • There were no postoperative complications, and the patient is alive and without tumor recurrence 12 months after four cycles of systemic chemotherapy according to the PEB (cisplatin, etoposide, bleomycin) scheme.
  • We conclude that in this special case aggressive surgical management following chemotherapy was very effective in controlling the disseminated testicular tumor.
  • [MeSH-major] Endodermal Sinus Tumor / secondary. Endodermal Sinus Tumor / surgery. Heart Neoplasms / secondary. Heart Neoplasms / surgery. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Bleomycin / administration & dosage. Cardiopulmonary Bypass. Cisplatin / administration & dosage. Etoposide / administration & dosage. Heart Atria / pathology. Heart Ventricles / pathology. Humans. Male. Orchiectomy. Pulmonary Embolism / etiology. Treatment Outcome. Vena Cava, Superior / pathology

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  • (PMID = 16440152.001).
  • [ISSN] 0910-8327
  • [Journal-full-title] Heart and vessels
  • [ISO-abbreviation] Heart Vessels
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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30. Kato N, Shibuya H, Fukase M, Tamura G, Motoyama T: Involvement of adenomatous polyposis coli (APC) gene in testicular yolk sac tumor of infants. Hum Pathol; 2006 Jan;37(1):48-53
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  • [Title] Involvement of adenomatous polyposis coli (APC) gene in testicular yolk sac tumor of infants.
  • The pathogenesis of testicular yolk sac tumor (YST) of infants is still unclear.
  • Infantile YSTs rarely show isochromosome 12p or aneuploidy, which are common in adult germ cell tumors.
  • On the other hand, recent epigenetic studies suggest the involvement of some tumor suppressor genes, including the adenomatous polyposis coli (APC) gene.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / genetics. Endodermal Sinus Tumor / genetics. Genes, APC. Loss of Heterozygosity. Testicular Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Child, Preschool. Chromosomes, Human, Pair 5. DNA Methylation. DNA Mutational Analysis. Gene Silencing. Humans. Immunohistochemistry. Infant. Male. Testis / anatomy & histology. Testis / metabolism

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  • (PMID = 16360415.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor
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31. Futagami M, Yokoyama Y, Shigeto T, Mizunuma H: A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall. Eur J Gynaecol Oncol; 2010;31(6):690-3
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  • [Title] A case of recurrent yolk sac tumor as spindle cell sarcoma of the abdominal wall.
  • Few studies report on tissue morphology in recurrence of yolk sac tumor.
  • The case of the recurrence of a yolk sac tumor as a spindle cell sarcoma of the abdominal wall is presented.
  • A 27-year-old woman was referred to our hospital due to suspicion of an ovarian tumor.
  • Right salpingo-oophorectomy, partial omentectomy, and extirpation of disseminated foci as fertility-preserving surgery was done since the intraoperative pathological diagnosis was yolk sac tumor.
  • Final pathological examination showed a germ cell tumor of which yolk sac tumor formed the major component including a small area that appeared to be immature nerve tissue.
  • Although residual tumor was not less than 1 cm, clinical complete remission was reached after the sixth course of BEP regimen.
  • However, the recurrence of a yolk sac tumor as an unclassified spindle cell sarcoma of the abdominal wall was found about two years after the initial surgery.
  • The mesenchyme-like component of the yolk sac tumor is characterized by spindle cells originating from epithelial elements, and is likely to give rise to a chemoresistant, diversely differentiated sarcoma.
  • This report suggests that the sarcoma reported in the case here also arose when spindle cells of the mesenchyme-like component underwent sarcomatous change during or after chemotherapy, subsequently relapsed as a chemoresistant tumor, and metastasized.
  • [MeSH-major] Abdominal Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Neoplasm Recurrence, Local / pathology. Sarcoma / pathology
  • [MeSH-minor] Abdominal Wall / pathology. Adult. Fatal Outcome. Female. Humans. Neoplasm Staging

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  • (PMID = 21319519.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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32. Haibin Z, Yue J, Yaxian X: Primary yolk sac tumor of the omentum: a case report and literature review. Eur J Gynaecol Oncol; 2010;31(6):682-4
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  • [Title] Primary yolk sac tumor of the omentum: a case report and literature review.
  • BACKGROUND: Yolk sac tumor (YST) is the second most common malignant ovarian germ cell tumor, while a YST arising in the omentum is an exceedingly rare malignancy.
  • The case of omental YST must be seriously considered once the tumor shows omentum thickening with elevated AFP serum levels.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / therapy. Omentum / surgery. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Female. Humans. Hysterectomy. Ovariectomy. Peritoneum / pathology. Treatment Outcome

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  • (PMID = 21319517.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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33. Kan P, Gottfried ON, Blumenthal DT, Liu JK, Salzman KL, Townsend J, Jensen RL: Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature. J Neurooncol; 2006 Jul;78(3):249-53
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  • [Title] Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature.
  • METHODS: We present the unique case of a 25-year-old woman with an intradural, extramedullary primary yolk sac tumor (YST) at and below the level of the conus medullaris.
  • Despite an initial reduction in tumor size and clinical improvement in her neurologic exam, she re-presented a year after surgery with gross enlargement of her spinal tumor and CSF dissemination with metastasis to her brain.
  • When feasible (no evidence of CSF dissemination, metastasis, or multifocal disease), optimal treatment includes as extensive resection of tumor as possible followed by adjuvant chemotherapy and radiation.
  • [MeSH-major] Brain Neoplasms / secondary. Endodermal Sinus Tumor / secondary. Neoplasm Recurrence, Local / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans

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  • (PMID = 16773223.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 16
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34. Razzi S, Luisi S, Gabbanini M, Lazzeri L, Mazzini M, Petraglia F: Yolk sac tumor in a young girl: a case report. Gynecol Endocrinol; 2005 Jun;20(6):334-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Yolk sac tumor in a young girl: a case report.
  • BACKGROUND: Yolk sac tumor is a rare neoplasm characterized by high malignancy given its premature metastasis, that is frequent in adolescence.
  • Following salpingo-oophorectomy, it was revealed as a yolk sac tumor by histological diagnosis.
  • CONCLUSION: This is an interesting case of yolk sac tumor in a young girl, at an age typical for germ cell tumor.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents. Combined Modality Therapy. Diagnosis, Differential. Fallopian Tubes / surgery. Female. Humans. Ovariectomy

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  • (PMID = 16019383.001).
  • [ISSN] 0951-3590
  • [Journal-full-title] Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • [ISO-abbreviation] Gynecol. Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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35. Hong DG, Chong GO, Seong WJ, Lee YS, Cho YL, Park JY, Chae JM, Park IS: A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman. Eur J Gynaecol Oncol; 2010;31(4):471-4
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  • [Title] A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman.
  • Ovarian yolk sac tumor (YST) is a malignant ovarian neoplasm differentiated from primordial germ cells that occur in young age, while endometrioid carcinoma (ECA) is a müllerian epithelial tumor that usually occurs in older patients.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry

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  • (PMID = 20882900.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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36. Ohishi Y, Kaku T, Kaneki E, Wake N, Tsuneyoshi M: Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: a case study. Gynecol Oncol; 2007 May;105(2):548-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: a case study.
  • BACKGROUND: Cases of malignant ovarian tumor composed of müllerian-type epithelial tumor and malignant germ cell tumor are extremely rare.
  • CASE: We herein report the case of a 34-year-old woman with an ovarian tumor which was composed of endometrioid adenocarcinoma (EAC), clear cell adenocarcinoma (CCC), squamous cell carcinoma, yolk sac tumor (YST) and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation.
  • Even after systemic chemotherapy, this intriguing tumor recurred again and again, which is in contrast to pure germ cell tumor which is known to be sensitive to chemotherapy.
  • Correct diagnosis of this complex and aggressive tumor is paramount.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adult. Carcinoma, Endometrioid / pathology. Carcinoma, Squamous Cell / pathology. Endodermal Sinus Tumor / pathology. Female. Humans. Neuroectodermal Tumors / pathology. Rhabdomyosarcoma / pathology. Teratoma / pathology


37. Basoglu A, Sengul AT, Buyukkarabacak YB, Yetim TD, Yildiz L: Pure yolk-sac tumor of the lung. Asian Cardiovasc Thorac Ann; 2008 Oct;16(5):410-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pure yolk-sac tumor of the lung.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bronchoscopy / methods. Chemotherapy, Adjuvant. Fiber Optic Technology. Humans. Male. Pneumonectomy. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18812352.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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38. Ulbright TM, Young RH: Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor. Am J Surg Pathol; 2005 Apr;29(4):500-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor.
  • The spaces often suggested reticular or microcystic patterns of yolk sac tumor, and the solid and hollow tubular patterns often added to the diagnostic confusion.
  • The hollow tubules appeared to result from central discohesion within nests of tumor.
  • The spaces, particularly when large, often contained occasional tumor cells or inflammatory cells within pale edema fluid.
  • The cytologic appearance of the cells lining the spaces, and in the surrounding tumor, retained the typical features of seminoma cells.
  • Distinction from yolk sac tumor is aided by the observation that the spaces of yolk sac tumor are often more irregular in their individual shapes and frequently form anastomosing channels.
  • Additionally, the spaces of yolk sac tumor randomly merge with various other yolk sac tumor patterns.
  • The cells lining spaces in yolk sac tumor are often flattened with compressed nuclei and lack the typical prominent nucleoli of seminoma cells.
  • Paucity of lymphocytes and intracystic edema, however, are not differentially helpful, although basophilic fluid favors yolk sac tumor.
  • A panel of immunostains (AE1/AE3, OCT-3/4, and alpha-fetoprotein) is helpful in the differential with yolk sac tumor in especially problematic cases.
  • The edema and paucity of lymphocytes may suggest spermatocytic seminoma, but the varied cell types of that neoplasm are absent.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Seminoma / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15767805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Al Masri W, Alhendal A, Al Mishaan M: A ruptured retroperitoneal germ cell tumor with invasion into the duodenum: a case report. Gulf J Oncolog; 2007 Jul;(2):69-72
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  • [Title] A ruptured retroperitoneal germ cell tumor with invasion into the duodenum: a case report.
  • We report a rare case of a retroperitoneal germ cell tumor in a 31 years old male who presented with an acute abdomen.
  • The final pathology revealed a yolk sac tumor.
  • We present this rare case of a primary para-aortic extragonadal yolk sac tumor and the differential diagnosis of a retroperitoneal mass.
  • [MeSH-major] Duodenal Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Neoplasms, Second Primary / pathology. Retroperitoneal Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Male. Neoplasm Invasiveness. Rupture, Spontaneous

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  • (PMID = 20084727.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
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40. Aoki Y, Higashino M, Ishii S, Tanaka K: Yolk sac tumor of the ovary during pregnancy: a case report. Gynecol Oncol; 2005 Nov;99(2):497-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Yolk sac tumor of the ovary during pregnancy: a case report.
  • CASE: We had a case of a 30-year-old pregnant woman with a yolk sac tumor who underwent right salpingo-oophorectomy at 22 weeks gestation.
  • Tumor recurrence was confirmed clinically at 34 weeks gestation.
  • CONCLUSION: AFP-L2 may be a sensitive indicator for a yolk sac tumor derived AFP, leading to an earlier detection of tumor recurrence during pregnancy.
  • [MeSH-major] Endodermal Sinus Tumor. Ovarian Neoplasms. Pregnancy Complications, Neoplastic
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Peplomycin / administration & dosage. Plant Lectins. Pregnancy. alpha-Fetoproteins / metabolism


41. Pafilis I, Haidopoulos D, Rodolakis A, Vlachos G, Voulgaris Z, Sotiropoulou M, Antsaklis A: Management of a pregnancy complicated by yolk sac tumor. Arch Gynecol Obstet; 2009 Nov;280(5):803-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of a pregnancy complicated by yolk sac tumor.
  • CASE: A 35-year-old pregnant woman with a yolk sac tumor underwent left salpingo-oophorectomy at 25 weeks of gestation.
  • CONCLUSION: In a case of yolk sac tumor in the second trimester of pregnancy, radical surgery combined with elective caesarian section followed by chemotherapy could achieve remission and rescue of fetus.
  • [MeSH-major] Endodermal Sinus Tumor / surgery. Ovarian Neoplasms / surgery. Pregnancy Complications, Neoplastic / surgery
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Cesarean Section. Female. Histocytochemistry. Humans. Hysterectomy. Infant, Newborn. Pregnancy. Pregnancy Trimester, Second. alpha-Fetoproteins / analysis

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  • (PMID = 19234710.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / alpha-Fetoproteins
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42. Kawabe M, Sasaki K, Shinoda T, Tanabe S, Handa M, Hirai S, Yamada N, Uesaka T, Morioka K, Ihaya A, Tanaka K, Imamura Y: [Yolk sac tumor of the anterior mediastinum and pulmonary metastases; report of a case]. Kyobu Geka; 2005 Nov;58(12):1102-5
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  • [Title] [Yolk sac tumor of the anterior mediastinum and pulmonary metastases; report of a case].
  • A 31-year-old female was clinically diagnosed as having a anterior mediastinal yolk sac tumor because of the elevation of the AFP (17,500 ng/ml), a large mass lesion (9 x 5 cm) in the anterior mediastinum and bilateral lung metastases.
  • The tumor was completely removed and there were no viable foci of the tumor in part of the tumor.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endodermal Sinus Tumor / secondary. Lung Neoplasms / secondary. Mediastinal Neoplasms / pathology. Superior Vena Cava Syndrome / complications
  • [MeSH-minor] Adult. Carboplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Etoposide / administration & dosage. Female. Fluorodeoxyglucose F18. Humans. Ifosfamide / administration & dosage. Positron-Emission Tomography. alpha-Fetoproteins / analysis

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  • (PMID = 16281866.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / alpha-Fetoproteins; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide
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43. Kim SW, Park JH, Lim MC, Park JY, Yoo CW, Park SY: Primary yolk sac tumor of the omentum: a case report and review of the literature. Arch Gynecol Obstet; 2009 Feb;279(2):189-92
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  • [Title] Primary yolk sac tumor of the omentum: a case report and review of the literature.
  • BACKGROUND: Extraovarian yolk sac tumors (YSTs) arising in the omentum represent an exceedingly rare malignancy.
  • A review of the literature indicates that the diagnosis of YST requires proper evaluations of tumor makers and a skilled pathologist for analysis of frozen sections.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Omentum. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Appendectomy. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Fallopian Tubes / surgery. Female. Histocytochemistry. Humans. Keratins / analysis. Lymph Node Excision. Ovariectomy. Peritoneum / pathology. Tomography, X-Ray Computed. alpha-Fetoproteins / analysis

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  • (PMID = 18648830.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / alpha-Fetoproteins; 11056-06-7 / Bleomycin; 68238-35-7 / Keratins; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
  • [Number-of-references] 17
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44. Petrakakou E, Grapsa D, Stergiou ME, Mikou P, Tsarpalis D, Polyzos A, Giahnaki A, Ioakim-Liossi A: Ascitic fluid cytology of yolk sac tumor of the ovary: a case report. Acta Cytol; 2009 Nov-Dec;53(6):701-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ascitic fluid cytology of yolk sac tumor of the ovary: a case report.
  • BACKGROUND: Yolk sac tumor (YST) of the ovary is a rare neoplasm typically affecting children and young women.
  • We describe the cytomorphology of this tumor in ascitic fluid and discuss its differential diagnosis from other neoplasms.
  • [MeSH-major] Ascitic Fluid / pathology. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Aggregation. Female. Humans. Periodic Acid-Schiff Reaction. alpha-Fetoproteins / metabolism

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  • (PMID = 20014563.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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45. Khunamornpong S, Siriaunkgul S, Suprasert P, Chitapanarux I: Yolk sac tumor of the vulva: a case report with long-term disease-free survival. Gynecol Oncol; 2005 Apr;97(1):238-42
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  • [Title] Yolk sac tumor of the vulva: a case report with long-term disease-free survival.
  • BACKGROUND: Yolk sac tumor (YST) of the vulva is extremely rare.
  • Three weeks after excision, right inguinal lymph node biopsy revealed metastatic tumor.
  • CONCLUSION: Local excision of tumor with adjuvant cisplatin-based chemotherapy can be justified for vulvar YST.
  • Tumor size of 5 cm or less may be a favorable prognostic factor.
  • [MeSH-major] Endodermal Sinus Tumor / therapy. Vulvar Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Disease-Free Survival. Female. Humans. Lymph Node Excision. Radiotherapy

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  • (PMID = 15790466.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
  • [Number-of-references] 20
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46. Cheng L, Zhang S, Talerman A, Roth LM: Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma. Hum Pathol; 2010 May;41(5):716-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma.
  • The results were compared to 4 cases of mixed germ cell tumor that were originally mistaken for embryonal carcinoma.
  • OCT4 marked the nuclei of 6 cases, among which 5 cases also showed glypican 3 expression indicative of an admixed yolk sac tumor component.
  • In 1 case of mixed germ cell tumor containing embryonal carcinoma, embryoid bodies from a component of polyembryoma were demonstrated to be both OCT4 and CD30 positive.
  • They were reclassified as solid variant of yolk sac tumor.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Embryonal / pathology. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Adult. Antigens, CD30 / genetics. Antigens, CD30 / metabolism. Chromosome Aberrations. Chromosomes, Human, Pair 12 / genetics. Chromosomes, Human, Pair 12 / metabolism. Diagnosis, Differential. Female. Glypicans / genetics. Glypicans / metabolism. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Octamer Transcription Factor-3 / genetics. Octamer Transcription Factor-3 / metabolism. Prognosis. SOXB1 Transcription Factors / genetics. SOXB1 Transcription Factors / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20096442.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Biomarkers, Tumor; 0 / Glypicans; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors
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47. Ceyhan K, Utkan G, Dincol D, Erdogan N, Erekul S, Umudum H: Fine needle aspiration biopsy features with histologic correlation in mediastinal hepatoid yolk sac tumor presenting with sternum metastasis: a case report. Acta Cytol; 2007 Jul-Aug;51(4):610-5
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  • [Title] Fine needle aspiration biopsy features with histologic correlation in mediastinal hepatoid yolk sac tumor presenting with sternum metastasis: a case report.
  • BACKGROUND: The hepatoid variant of yolk sac tumor (H-YST) is an exceedingly rare and highly malignant neoplasm.
  • No tumor was found in the other organ systems.
  • Cytologically, the tumor was composed of monotonous, large, round to polygonal hepatoid cells forming solid sheets and trabeculae entrapped with endothelial cells resembling hepatocellular carcinoma.
  • Histopathologic sections of tumor showed tumor cells with eosinophilic to clear cytoplasm arranged in a solid, trabecular growth pattern, with some acinar formations.
  • CONCLUSION: Fine needle aspiration cytology, together with the characteristic clinical presentations and specific tumor markers, is crucial to the initial diagnosis of H-YST.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Mediastinal Neoplasms / pathology. Sternum / pathology
  • [MeSH-minor] Adult. Antibodies. Biopsy, Fine-Needle. Endothelial Cells / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Metastasis. alpha-Fetoproteins / metabolism

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  • (PMID = 17718136.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / alpha-Fetoproteins
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48. McBee WC Jr, Brainard J, Sawady J, Rose PG: Yolk sac tumor of the ovary associated with endometrioid carcinoma with metastasis to the vagina: a case report. Gynecol Oncol; 2007 Apr;105(1):244-7
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  • [Title] Yolk sac tumor of the ovary associated with endometrioid carcinoma with metastasis to the vagina: a case report.
  • BACKGROUND: Mixed yolk sac tumors of the ovary are biologically aggressive even in early stage disease.
  • CASE: A 41-year-old woman presented with a large pelvic mass and anterior vaginal wall tumor.
  • Pathology of the ovary revealed a primary yolk sac tumor associated with poorly differentiated endometrioid and undifferentiated carcinoma with vaginal metastasis only.
  • CONCLUSION: To our knowledge this is the first case of a mixed ovarian germ cell tumor with vaginal metastasis.
  • [MeSH-major] Carcinoma, Endometrioid / secondary. Endodermal Sinus Tumor / secondary. Ovarian Neoplasms / pathology. Vaginal Neoplasms / secondary
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans

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  • (PMID = 17316775.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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49. Tinica G, Butcovan D, Cimpeanu C, Târcoveanu E: A mediastinal germ cell tumor of yolk sac type--case report. Chirurgia (Bucur); 2010 Nov-Dec;105(6):831-4
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  • [Title] A mediastinal germ cell tumor of yolk sac type--case report.
  • OBJECTIVE: We report an extremely rare case of germ-cell tumor localized at the level of the anterior mediastinum.
  • Surgical intervention revealed an infiltrative mediastinal tumor involving the left subclavial vein, which was biopsied for morphological examination.
  • Immunohistochemical stains for alpha-fetoprotein were positive in the tumor cells while stains for carcinoembryonic antigen and placental like alkaline phosphatase were negative.
  • This supported the diagnosis of Yolk sac tumor, a rare primary tumor within the mediastinum.
  • CONCLUSION: Primary mediastinal Yolk sac neoplasm is a rare tumor.
  • In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor.
  • The single most important prognostic indicator is whether the tumor mass can be completely excised before or after chemotherapy.
  • [MeSH-major] Endodermal Sinus Tumor. Mediastinal Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Biopsy. Bleomycin / administration & dosage. Carcinoma / diagnosis. Cisplatin / administration & dosage. Diagnosis, Differential. Etoposide / administration & dosage. Humans. Male. Prognosis. alpha-Fetoproteins / metabolism

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  • (PMID = 21351701.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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50. Ui T, Horie H, Sato H, Miyakura Y, Sakuma Y, Hyodo M, Togashi K, Yasuda Y, Nagai H, Matsubara D: [Sigmoid colon cancer in a woman developing 22 years after radiation therapy for a yolk sac tumor]. Nihon Shokakibyo Gakkai Zasshi; 2009 May;106(5):668-73
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  • [Title] [Sigmoid colon cancer in a woman developing 22 years after radiation therapy for a yolk sac tumor].
  • She had undergone surgical resection following chemotherapy for yolk sac tumor at the age of 12 years, and had received additional surgery and radiation therapy for a local recurrence at age 13.
  • Following evaluation, a sigmoid colon tumor was detected and was surgically resected.
  • [MeSH-major] Adenocarcinoma / etiology. Endodermal Sinus Tumor / radiotherapy. Ovarian Neoplasms / radiotherapy. Radiotherapy / adverse effects. Sigmoid Neoplasms / etiology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Chronic Disease. Colitis / etiology. Female. Humans. Neoplasm Recurrence, Local. Ovariectomy. Time Factors

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  • (PMID = 19420871.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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51. Tran TA, Ortiz HB, Holloway RW, Bigsby GE, Finkler NJ: Alpha-fetoprotein-producing serous carcinoma of the uterus metastasizing to the ovaries, mimicking primary ovarian yolk sac tumor: a case report and review of the literature. Int J Gynecol Pathol; 2007 Jan;26(1):66-70
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  • [Title] Alpha-fetoprotein-producing serous carcinoma of the uterus metastasizing to the ovaries, mimicking primary ovarian yolk sac tumor: a case report and review of the literature.
  • In the uterus, most alpha-fetoprotein (AFP) producing neoplasms belong to the categories of malignant mixed muellerian tumor, hepatoid carcinoma, and yolk sac tumor.
  • We describe the case of a 44-year-old woman who presented with vaginal bleeding, pelvic mass, and preoperative elevated AFP serum level, clinically suggestive of a primary ovarian yolk sac tumor.
  • Upon review of the literature on primary endometrial neoplasms with AFP production, 2 categories with possibly different histogenesis and biological behavior become evident: the primary yolk sac tumor of the uterus in young patients (range, 24-49 years; mean, 34 years) and the common high grade endometrial carcinoma with yolk sac dedifferentiation or aberrant AFP production in elderly patients (range, 55-69 years; mean, 63.7 years).
  • [MeSH-major] Endodermal Sinus Tumor / metabolism. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Uterine Neoplasms / metabolism. Uterine Neoplasms / pathology. alpha-Fetoproteins / biosynthesis
  • [MeSH-minor] Adult. Biomarkers, Tumor. Female. Humans. Molecular Mimicry

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  • (PMID = 17197899.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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52. Calaminus G, Schneider DT, Weissbach L, Schönberger S, Okpanyi V, Leuschner I, Poremba C, Göbel U: Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor. Klin Padiatr; 2009 May-Jun;221(3):136-40
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  • [Title] Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor.
  • This specific situation with progressive tumor growth and simultaneous normalization of tumor markers during or after treatment of malignant GCTs with teratomatous elements is judged as a fatal situation if this situation can not be controlled by extensive surgery, as teratoma are not sensible to chemotherapy or irradiation.
  • Within the molecular profile of the tumor we could find a cytogenetic picture typically found in malignant adult GCTs.
  • In view of the bulky abdominal, thoracic and cervical metastases and the uncontrolled tumor progression, the situation was considered incurable.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / surgery. Lymph Node Excision. Lymphatic Metastasis. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / surgery. Neoplasms, Multiple Primary / drug therapy. Neoplasms, Multiple Primary / surgery. Teratoma / drug therapy. Teratoma / surgery. Testicular Neoplasms / drug therapy. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Monoclonal, Humanized. Bevacizumab. Combined Modality Therapy. Dose-Response Relationship, Drug. Drug Administration Schedule. Follow-Up Studies. Humans. Interferon-alpha / administration & dosage. Interferon-alpha / adverse effects. Lymph Nodes / blood supply. Lymph Nodes / pathology. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Recombinant Proteins. Reoperation. Salvage Therapy. Survival Rate. Thalidomide / administration & dosage. Thalidomide / adverse effects. Tomography, X-Ray Computed. Vinblastine / administration & dosage. Vinblastine / adverse effects

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  • [CommentIn] Klin Padiatr. 2009 May-Jun;221(3):134-5 [19437359.001]
  • (PMID = 19437360.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Interferon-alpha; 0 / Recombinant Proteins; 2S9ZZM9Q9V / Bevacizumab; 4Z8R6ORS6L / Thalidomide; 5V9KLZ54CY / Vinblastine; 76543-88-9 / interferon alfa-2a
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53. de La Motte Rouge T, Pautier P, Duvillard P, Rey A, Morice P, Haie-Meder C, Kerbrat P, Culine S, Troalen F, Lhommé C: Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. Ann Oncol; 2008 Aug;19(8):1435-41
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  • [Title] Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor.
  • BACKGROUND: Ovarian yolk sac tumor (YST) is a very rare malignancy arising in young women.
  • However, given the rarity of this tumor, ovarian YST-specific survival and outcome after such treatment are not precisely known.

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  • (PMID = 18408223.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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54. Takahama A Jr, León JE, de Almeida OP, Kowalski LP: Nonlymphoid mesenchymal tumors of the parotid gland. Oral Oncol; 2008 Oct;44(10):970-4

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  • 15 out of 19 were benign tumors, including 5 lymphangiomas, 5 neurofibromas, and one case each of schwannoma, lipoma, solitary fibrous tumor, meningioma and giant cell tumor.
  • Four malignant tumors were classified as rhabdomyosarcoma, fibrosarcoma, Langerhans cell histiocytosis and endodermal sinus tumor.
  • From the malignant cases, only the patient with fibrosarcoma died due the tumor, the other three are alive with no signs of recurrence.
  • [MeSH-minor] Adolescent. Adult. Aged. Brazil. Child. Child, Preschool. Diagnosis, Differential. Endodermal Sinus Tumor / pathology. Female. Fibrosarcoma / pathology. Histiocytosis, Langerhans-Cell / pathology. Humans. Infant. Male. Middle Aged. Neurofibroma / pathology. Rhabdomyosarcoma / pathology. Young Adult

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  • (PMID = 18282791.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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55. Choi HJ, Moon MH, Kim SH, Cho JY, Jung DC, Hong SR: Yolk sac tumor of the ovary: CT findings. Abdom Imaging; 2008 Nov-Dec;33(6):736-9
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  • [Title] Yolk sac tumor of the ovary: CT findings.
  • BACKGROUND: The purpose of this study was to evaluate computed tomographic (CT) findings of pathologically proven yolk sac tumors of the ovary.
  • METHODS: Two radiologists retrospectively evaluated CT findings of 10 yolk sac tumors in consensus.
  • CONCLUSIONS: On CT scans, ovarian yolk sac tumors appeared as large, unilateral, smooth marginated mass with bright dot sign and necrotic portion.
  • [MeSH-major] Endodermal Sinus Tumor / radiography. Ovarian Neoplasms / radiography. Ovary / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adolescent. Adult. Child. Contrast Media. Female. Humans. Iohexol / analogs & derivatives. Observer Variation. Radiographic Image Enhancement / methods. Retrospective Studies. Young Adult

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  • (PMID = 18253781.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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56. Harms D, Zahn S, Göbel U, Schneider DT: Pathology and molecular biology of teratomas in childhood and adolescence. Klin Padiatr; 2006 Nov-Dec;218(6):296-302
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  • The biologic behaviour of teratomas depends on various interdependent clinical and epidemiologic variables such as the age at diagnosis, sex, tumor site, histology which all correlate to different cytogenetic and molecular biologic aberrations.
  • The Kiel Pediatric Tumor Registry includes 541 teratoma specimens, and among these, the most frequent tumor sites (in descending order) are: the sacrococcygeal region (33.8 %), the ovaries (31.2 %) and the testes (10.5 %).
  • The frequency of additional microscopic foci of malignant yolk sac tumor correlates with the grade of immaturity.
  • In sacrococcygeal teratomas, the yolk sac tumor microfoci may give rise to a malignant relapse after incomplete resection.
  • Here, molecular genetic analysis has demonstrated the origin of the somatic malignancy from a malignant transformation within the germ cell tumor with retention of the cytogenetic changes characteristic of malignant germ cell tumors.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Chromosome Aberrations. Chromosome Deletion. Cytogenetic Analysis. Endodermal Sinus Tumor / epidemiology. Endodermal Sinus Tumor / pathology. Female. Germany / epidemiology. Heterozygote. Humans. Incidence. Infant. Infant, Newborn. Male. Ovary / pathology. Puberty. Testis / pathology

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  • (PMID = 17080330.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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57. Nishioka H, Haraoka J, Miki T: Management of intracranial germ cell tumors presenting with rapid deterioration of consciousness. Minim Invasive Neurosurg; 2006 Apr;49(2):116-9
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  • PATIENTS: We report three patients who presented with rapid deterioration of consciousness but resulted in complete remission of the tumor after emergency surgery for both diagnostic (biopsy) and therapeutic (for hydrocephalus) purposes followed by prompt initiation of radiochemotherapy.
  • Thus, emergency surgery with a less invasive procedure is the first choice of treatment, i. e., endoscopic surgery for pineal region tumor and CT-guided biopsy for basal ganglia tumor.
  • [MeSH-major] Brain Neoplasms / surgery. Consciousness Disorders / etiology. Endodermal Sinus Tumor / surgery. Germinoma / surgery. Seminoma / surgery
  • [MeSH-minor] Adult. Child. Humans. Male. Testicular Neoplasms / pathology. Time Factors

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  • (PMID = 16708342.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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58. Kajo K, Macháleková K, Laca L: [Unusual clinical presentation of hepatic yolk sac tumour in periappendical region. A case report and review of the literature]. Cesk Patol; 2009 Oct;45(4):113-6
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  • [Title] [Unusual clinical presentation of hepatic yolk sac tumour in periappendical region. A case report and review of the literature].
  • [Transliterated title] Nezvycajná klinická prezentácia pecenového yolk sac tumoru v periapendikálnej oblasti. Kazuistika a prehl'ad literatúry.
  • Primary hepatic yolk sac tumour (YST) is a very rare neoplasm.
  • Consequently, there was discovered a tumor in the liver and the patient underwent right hemihepatectomy, hemicolectomy and ovariectomy, from which the YST was disclosed in the liver and in the coecum with spread into regional lymph nodes.
  • It has been suggested that these YSTs might originate from the germ cells that escaped during migration course from the yolk sac to the genital ridge during embryogenesis with subsequent malignant transformation or from persistent pluripotent embryonic cells in the liver, which escaped from the influence of differentiation during embryogenesis.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Appendix / pathology. Female. Humans. Young Adult

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  • (PMID = 20301839.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 39
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59. De Jong J, Weeda S, Gillis AJ, Oosterhuis JW, Looijenga LH: Differential methylation of the OCT3/4 upstream region in primary human testicular germ cell tumors. Oncol Rep; 2007 Jul;18(1):127-32
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  • Expression regulation of OCT3/4 has been extensively studied in murine and human cell lines, including embryonic stem cell lines and tumor derived cell lines.
  • Normal testis parenchyma, peripheral blood lymphocytes, spermatocytic seminoma, yolk sac tumor and teratoma, and JKT-1 showed a consistent hypermethylation.
  • In contrast, seminoma and embryonal carcinoma were hypomethylated, confirmed by analyses after tumor micro-dissection.
  • In conclusion, the results obtained from this set of adult normal and neoplastic in vivo derived samples is in accordance to the in vitro data that expression of OCT3/4 is associated with specific changes in methylation.
  • [MeSH-major] DNA Methylation. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Neoplasms, Germ Cell and Embryonal / genetics. Octamer Transcription Factor-3 / genetics. Promoter Regions, Genetic / genetics. Testicular Neoplasms / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Carcinoma, Embryonal / genetics. Carcinoma, Embryonal / pathology. Cells, Cultured. Endodermal Sinus Tumor / genetics. Endodermal Sinus Tumor / pathology. Humans. Male. RNA, Messenger / genetics. RNA, Messenger / metabolism. Seminoma / genetics. Seminoma / pathology. Teratoma / genetics. Teratoma / pathology. Testis / metabolism. Testis / pathology

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  • (PMID = 17549357.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Octamer Transcription Factor-3; 0 / RNA, Messenger
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60. Murugan P, Siddaraju N, Sridhar E, Soundararaghavan J, Habeebullah S: Unusual ovarian malignancies in ascitic fluid: a report of 2 cases. Acta Cytol; 2010 Jul-Aug;54(4):611-7
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  • However, subsequent histopathologic examination showed them to be yolk sac tumor (YST) and juvenile granulosa cell tumor (JGCT).
  • [MeSH-major] Ascites / pathology. Endodermal Sinus Tumor / pathology. Granulosa Cell Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Hyalin / metabolism. Immunohistochemistry. Young Adult

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  • (PMID = 20715666.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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61. Hamid AR, Umbas R: Metastasis of testicular carcinoma in the inguinal region. Acta Med Indones; 2009 Jan;41(1):25-9
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  • For this case, surgical treatment of residual tumor excision had been performed prior to the chemotherapy considering a quite large size of tumor mass, which may easily bleed and causing anemia to the patient.
  • Furthermore, we considered that chemotherapy treatment prior to surgical excision will only provide partial effect on the tumor.
  • [MeSH-major] Carcinoma, Embryonal / secondary. Choriocarcinoma / secondary. Endodermal Sinus Tumor / secondary. Seminoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Fatal Outcome. Groin. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Neoplasm, Residual. Skin Transplantation

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  • (PMID = 19258677.001).
  • [ISSN] 0125-9326
  • [Journal-full-title] Acta medica Indonesiana
  • [ISO-abbreviation] Acta Med Indones
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Indonesia
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62. Knezević V, Poljak M, Bradamante Z, Serman D, Levak-Svajger B, Svajger A: Yolk sac carcinoma derived from the rat epiblast as a renal isograft. Coll Antropol; 2005 Jun;29(1):189-97
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  • [Title] Yolk sac carcinoma derived from the rat epiblast as a renal isograft.
  • We report the novel observation that a biphasic, parieto-visceral (PYS/VYS) yolk sac carcinoma can develop from the isolated epiblast of the pre-primitive streak rat embryo in a prolonged cultivation in vivo as a renal isograft.
  • From the rest of the cylinder the 4 cell layers were isolated and transplanted separately under the kidney capsule of isogenic adult males.
  • After 4 weeks the hypoblast was resorbed, the extraembryonic ectoderm gave rise to hemorrhagic cysts and trophoblastic giant cells, the extraembryonic (visceral yolk sac) endoderm formed benign cystic PYS/VYS tumors, and the epiblast developed into a benign teratoma.
  • After prolonged (7-30 weeks) development of these teratomas as isografts, a malignant yolk sac carcinoma (YSC) developed in 45% of them.
  • It destroyed the teratoma and the recipient's kidney, metastasized to peritoneum and other sites, and caused abundant ascites containing clustered tumor cells.
  • The primary tumor was retransplantable subcutaneously as well as intraperitoneally, and displayed the characteristics of the mixed or biphasic PVYS carcinoma, with a progressive loss of the VYS component with time.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / veterinary. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / veterinary. Kidney Neoplasms / pathology. Kidney Neoplasms / veterinary. Teratoma / pathology. Teratoma / veterinary
  • [MeSH-minor] Animals. Ascites. Ectoderm. Embryo, Mammalian. Female. Kidney / pathology. Male. Neoplasm Metastasis. Neoplasms, Experimental. Rats. Transplants

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  • (PMID = 16117321.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Croatia
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63. Radhika S, Bakshi A, Rajwanshi A, Nijhawan R, Das A, Kakkar N, Joshi K, Marwaha RK, Rao KL: Cytopathology of uncommon malignant renal neoplasms in the pediatric age group. Diagn Cytopathol; 2005 May;32(5):281-6
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  • These include the common Wilms' tumor/nephroblastoma and the uncommon neoplasms such as clear-cell sarcoma of the kidney (CCSK), rhabdoid tumor, renal-cell carcinoma, and others.
  • Aspirates from Wilms' tumor, which are mesenchyme predominant, show clusters of spindle cells associated with the matrix material.
  • Renal-cell carcinoma of childhood shows similar cytological features as its adult counterpart.
  • Rhabdoid tumor of the kidney is characterized by a monomorphic population of cells with abundant cytoplasm, eccentric nuclei with prominent nucleoli.
  • Intrarenal yolk sac tumor is a rare neoplasm and shows severely pleomorphic cells on aspiration.
  • Further, non-Wilms' renal malignant neoplasms must be distinguished from the common Wilms' tumor so that appropriate chemotherapy protocols may be instituted in cases where the tumor is in an advanced stage of malignancy.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Renal Cell / pathology. Endodermal Sinus Tumor / pathology. Kidney Neoplasms / pathology. Rhabdoid Tumor / pathology. Sarcoma, Clear Cell / pathology
  • [MeSH-minor] Adolescent. Cell Nucleus / pathology. Child. Child, Preschool. Diagnosis, Differential. Humans. Infant. Staining and Labeling. Wilms Tumor / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15830360.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Tong X, You Q, Li L, Cai L, Wang C, Zheng J: Prognostic factors of patients with ovarian yolk sac tumors: a study in Chinese patients. Onkologie; 2008 Dec;31(12):679-84
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  • [Title] Prognostic factors of patients with ovarian yolk sac tumors: a study in Chinese patients.
  • BACKGROUND: The aim of this study was to investigate the prognostic factors of ovarian yolk sac tumors (YST) and the survival rates in Chinese patients.
  • Age, histologic type, preoperative serum alpha-fetoprotein level, fertility-sparing surgery, tumor size and lymphadenectomy did not affect the prognosis of YST in our study.
  • Multivariate analysis confirmed cisplatin-based chemotherapy (hazard ratio (HR) = 4.945), chemotherapy courses > 3 (HR = 2.954), residual tumor < or = 2 cm (HR = 0.224) and ascites volume < or = 100 ml (HR = 0.389) as independent predictors for overall survival.
  • Cisplatin-based chemotherapy, chemotherapy courses, residual tumor size and ascites volume were independent prognosis factors.
  • [MeSH-major] Endodermal Sinus Tumor / mortality. Endodermal Sinus Tumor / therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / prevention & control. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / mortality
  • [MeSH-minor] Adult. China / epidemiology. Female. Humans. Middle Aged. Prevalence. Prognosis. Proportional Hazards Models. Risk Assessment / methods. Risk Factors. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19060506.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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65. Miller JS, Lee TK, Epstein JI, Ulbright TM: The utility of microscopic findings and immunohistochemistry in the classification of necrotic testicular tumors: a study of 11 cases. Am J Surg Pathol; 2009 Sep;33(9):1293-8
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  • The submitting pathologists favored benign processes in 4 cases, Leydig cell tumor in 1, and lymphoma in 1.
  • Mean tumor size was 19 mm (range 7-53).
  • The combination of histologic features, immunostains and, in 1 case, serum AFP permitted classification of 8 tumors (4 seminomas, 3 embryonal carcinomas, 1 yolk sac tumor).
  • OCT4 stained 1 unclassifiable tumor, which lacked other specific markers.
  • We did not find placental alkaline phosphatase, AFP, and S100 stains useful, although S100 did highlight tumor "ghost" cells in 1 case.
  • Other features in most cases included intratubular germ cell neoplasia (6/11), tubular atrophy/hyalinization (10/11), tumor "ghost" cells (10/11), scar (9/11), and inflammation (10/11).
  • Of the 5 patients with available follow-up, 3 were free of disease at 1, 5, and 8 years after orchiectomy (2 necrotic seminomas and 1 germ cell tumor, unclassified).
  • One patient with yolk sac tumor (age 63 y) developed widespread metastases after 15 months and died of disease.
  • [MeSH-major] Carcinoma, Embryonal / classification. Endodermal Sinus Tumor / classification. Seminoma / classification. Testicular Neoplasms / classification
  • [MeSH-minor] Adolescent. Adult. Antigens, CD30 / analysis. Biomarkers, Tumor / analysis. Disease-Free Survival. Humans. Immunohistochemistry / methods. Keratins / analysis. Male. Middle Aged. Necrosis. Octamer Transcription Factor-3 / analysis. Orchiectomy. Proto-Oncogene Proteins c-kit / analysis. Young Adult. alpha-Fetoproteins / analysis

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  • (PMID = 19461507.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Biomarkers, Tumor; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / alpha-Fetoproteins; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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66. Dimov ND, Zynger DL, Luan C, Kozlowski JM, Yang XJ: Topoisomerase II alpha expression in testicular germ cell tumors. Urology; 2007 May;69(5):955-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Primary GCT specimens from 109 patients, including 57 seminomas and 52 mixed GCTs (41 embryonal carcinomas, 23 yolk sac tumors, 19 seminomas, 8 choriocarcinomas, 17 teratomas with immature elements, and 16 teratomas with mature elements), were obtained from our archives.
  • The metastatic lesions from 11 of the patients with mixed GCTs included seven teratomas with mature components, five embryonal carcinomas, one yolk sac tumor, one choriocarcinoma, and one teratoma with immature components.
  • RESULTS: Most embryonal carcinoma (100%), yolk sac tumor (95%), seminoma (88%), and choriocarcinoma (62%) components of the GCTs were TopoIIalpha immunoreactive.
  • CONCLUSIONS: The results of our study have shown that TopoIIalpha is expressed in most seminomas, embryonal carcinomas, yolk sac tumors, and choriocarcinomas, suggesting a possible mechanism of sensitivity of these components to TopoIIalpha inhibitors.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / analysis. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / antagonists & inhibitors. DNA-Binding Proteins / metabolism. Neoplasms, Germ Cell and Embryonal / enzymology. Testicular Neoplasms / enzymology. Topoisomerase II Inhibitors
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / enzymology. Carcinoma, Embryonal / pathology. Choriocarcinoma / drug therapy. Choriocarcinoma / enzymology. Choriocarcinoma / pathology. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / enzymology. Endodermal Sinus Tumor / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Sampling Studies. Seminoma / drug therapy. Seminoma / enzymology. Seminoma / pathology. Sensitivity and Specificity. Teratoma / drug therapy. Teratoma / enzymology. Teratoma / pathology. Treatment Outcome

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  • (PMID = 17482942.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Topoisomerase II Inhibitors; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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67. Akdogan B, Divrik RT, Tombul T, Yazici S, Tasar C, Zorlu F, Ozen H: Bilateral testicular germ cell tumors in Turkey: increase in incidence in last decade and evaluation of risk factors in 30 patients. J Urol; 2007 Jul;178(1):129-33; discussion 133
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  • PURPOSE: The relative risk of germ cell testicular tumor is significantly higher in patients with a testicular tumor history.
  • The second tumor occurred within 2 and 5 years in 20.8% and 41.7% of patients, respectively.
  • Synchronous tumors had similar tumor histology on each side and more advanced stage at presentation than metachronous tumors.
  • CONCLUSIONS: The risk of contralateral testicular germ cell tumor in patients with seminoma was 2 times higher than in those without a history of tumor.
  • [MeSH-minor] Adult. Endodermal Sinus Tumor / epidemiology. Humans. Incidence. Male. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Second Primary / epidemiology. Retrospective Studies. Risk Factors. Seminoma / epidemiology. Teratoma / epidemiology. Turkey / epidemiology

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  • [CommentIn] J Urol. 2007 Nov;178(5):2222-3; author reply 2223 [17870106.001]
  • [ErratumIn] J Urol. 2007 Sep;178(3 Pt 1):1125. Bulent, Akdogan [corrected to Akdogan, Bulent]; Taner, Divrik Rauf [corrected to Divrik, Rauf Taner]; Tolga, Tombul [corrected to Tombul, Tolga]; Sertac, Yazici [corrected to Yazici, Sertac]; Celik, Tasar [corrected to Tasar, Celik]; Ferruh, Zorlu [corrected to Zorlu, Ferruh]; Haluk, Ozen [corrected to Ozen, Haluk]
  • (PMID = 17499297.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Shoji S, Shima M, Usui Y, Nagata Y, Uchida T, Terachi T: [A case report: simultaneous bilateral testicular tumors with different cell types--complete response after combination chemotherapy of cisplatin and irrinotecan hydrochloride--]. Hinyokika Kiyo; 2006 Apr;52(4):303-6
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  • Histopathological examination of the excised tumors revealed seminoma, embryonal carcinoma, yolk sac tumor and immature teratoma in the right testis and seminoma in the left testis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endodermal Sinus Tumor / drug therapy. Neoplasms, Multiple Primary. Salvage Therapy. Seminoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adult. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Humans. Lung Neoplasms / secondary. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Remission Induction

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  • (PMID = 16686361.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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69. Shintaku I, Satoh M, Okajima E, Fujimoto H, Kamoto T, Ogawa O, Kawai K, Akaza H, Tsukamoto T, Naito S, Miki T, Arai Y: Survival of metastatic germ cell cancer patients assessed by international germ cell consensus classification in Japan. Jpn J Clin Oncol; 2008 Apr;38(4):281-7
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  • In 227 non-seminomatous germ cell tumor cases, the 5-year progression-free survival (95% confidence interval) for good (n = 55), intermediate (n = 106) and poor (n = 66) prognosis was 96% (91-100), 71% (62-80) and 52% (39-65) (P < 0.001), respectively.
  • [MeSH-minor] Adolescent. Adult. Aged. Choriocarcinoma / diagnosis. Choriocarcinoma / epidemiology. Disease-Free Survival. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / epidemiology. Humans. Japan / epidemiology. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Seminoma / diagnosis. Seminoma / epidemiology. Survival Rate. Teratoma / diagnosis. Teratoma / epidemiology

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  • (PMID = 18321891.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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70. Lee M, Grassi M: Acanthosis nigricans in a patient treated with palifermin. Cutis; 2010 Sep;86(3):136-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Endodermal Sinus Tumor / therapy. Hematopoietic Stem Cell Transplantation / adverse effects. Humans. Male. Mediastinal Neoplasms / therapy

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  • (PMID = 21049730.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 126469-10-1 / Fibroblast Growth Factor 7
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71. Kawauchi S, Yamamoto Y, Uchida K, Chochi Y, Kondo T, Oga A, Sasaki K: Significance of cyclin E and p27 expression in malignant ovarian germ cell tumors: correlation with the cell proliferation activity and clinicopathologic features. Oncol Rep; 2006 Nov;16(5):1029-33
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  • The labeling index (LI) was calculated as a percentage of the positively stained tumor cells per total tumor cells counted. p27 LIs showed a significant inverse correlation with Ki-67 LIs in MOGCTs examined (p<0.05).
  • The cyclin E LIs of yolk sac tumors were significantly higher than those of dysgerminomas (p<0.01).
  • [MeSH-minor] Adolescent. Adult. Cell Growth Processes / physiology. Child. CpG Islands. DNA Methylation. Endodermal Sinus Tumor / genetics. Endodermal Sinus Tumor / metabolism. Endodermal Sinus Tumor / pathology. Female. Humans. Immunohistochemistry. Middle Aged. Polymerase Chain Reaction / methods. Promoter Regions, Genetic

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  • (PMID = 17016588.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cyclin E; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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72. Bing Z, Pasha T, Tomaszewski JE, Zhang P: CDX2 expression in yolk sac component of testicular germ cell tumors. Int J Surg Pathol; 2009 Oct;17(5):373-7
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  • [Title] CDX2 expression in yolk sac component of testicular germ cell tumors.
  • Yolk sac tumor (YST) was identified by morphology and glypican 3 staining in 20 testicular mixed GCTs.
  • [MeSH-major] Endodermal Sinus Tumor / metabolism. Homeodomain Proteins / metabolism. Seminoma / metabolism. Testicular Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adult. Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Glypicans / metabolism. Humans. Male. Middle Aged. Neoplasms, Unknown Primary / diagnosis. Young Adult

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  • (PMID = 19578052.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Glypicans; 0 / Homeodomain Proteins
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73. Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T: Nestin expression in central nervous system germ cell tumors. Neurosurg Rev; 2008 Apr;31(2):173-6; discussion 176-7

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  • Nestin is an intermediate filament protein expressed in undifferentiated cells during CNS development and in CNS tumors and is used as a marker of immature elements of tumors, including brain tumor stem cells.
  • In this study, we examined for the first time nestin expression in 19 CNS germ cell tumors (nine pure germinomas, five germinomas with syncytiotrophoblastic giant cells, one yolk sac tumor, one choriocarcinoma, one embryonal carcinoma, and two mature teratomas).
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Biomarkers, Tumor / genetics. Central Nervous System Neoplasms / genetics. Intermediate Filament Proteins / biosynthesis. Intermediate Filament Proteins / genetics. Neoplasms, Germ Cell and Embryonal / genetics. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Choriocarcinoma / genetics. Choriocarcinoma / metabolism. Choriocarcinoma / pathology. Endodermal Sinus Tumor / genetics. Endodermal Sinus Tumor / metabolism. Endodermal Sinus Tumor / pathology. Female. Germinoma / genetics. Germinoma / metabolism. Germinoma / pathology. Giant Cell Tumors / genetics. Giant Cell Tumors / metabolism. Giant Cell Tumors / pathology. Humans. Hypopituitarism / etiology. Immunoenzyme Techniques. Magnetic Resonance Imaging. Male. Nestin. Teratoma / genetics. Teratoma / metabolism. Teratoma / pathology. Vision Disorders / etiology

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  • (PMID = 18092184.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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74. Abood G, Bowen M, Potkul R, Aranha G, Shoup M: Hepatic resection for recurrent metastatic ovarian cancer. Am J Surg; 2008 Mar;195(3):370-3; discussion 373
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary tumor type included serous cystadenocarcinoma (n = 8), granulosa cell (n = 1), and yolk sac (n = 1).
  • [MeSH-major] Hepatectomy. Liver Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Cystadenocarcinoma / secondary. Cystadenocarcinoma / surgery. Endodermal Sinus Tumor / secondary. Endodermal Sinus Tumor / surgery. Female. Granulosa Cell Tumor / secondary. Granulosa Cell Tumor / surgery. Humans. Middle Aged. Retrospective Studies

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  • (PMID = 18207130.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] United States
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75. Besse B, Grunenwald D, Fléchon A, Caty A, Chevreau C, Culine S, Théodore C, Fizazi K: Nonseminomatous germ cell tumors: assessing the need for postchemotherapy contralateral pulmonary resection in patients with ipsilateral complete necrosis. J Thorac Cardiovasc Surg; 2009 Feb;137(2):448-52
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  • Avoiding contralateral lung surgery could therefore be considered when complete necrosis is found in the first lung after induction chemotherapy for nonseminomatous germ cell tumor.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Choriocarcinoma / drug therapy. Choriocarcinoma / pathology. Cisplatin / therapeutic use. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / pathology. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Mediastinal Neoplasms / secondary. Necrosis. Retroperitoneal Neoplasms / secondary. Retrospective Studies. Teratoma / drug therapy. Teratoma / pathology. Young Adult

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  • (PMID = 19185168.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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76. Akhavizadegan H: Benefit of sperm freezing before radical orchiectomy. Clin Transl Oncol; 2009 Dec;11(12):849-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Endodermal Sinus Tumor / surgery. Freezing. Orchiectomy. Semen Preservation. Testicular Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Oligospermia / etiology. Oligospermia / therapy. Risk Assessment

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  • (PMID = 20045792.001).
  • [ISSN] 1699-3055
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] Spain
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77. Gyorffy H, Tihanyi T, Gyökeres T, Zsirka-Klein A, Kádár P, Kaszás I, Kovács M: [Pancreas pseudocyst or metastasis?]. Orv Hetil; 2005 Oct 23;146(43):2223-6
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  • Both histologically and immunohistochemically the lesion proved to be the metastasis of a germ cell (yolk-sac) tumour.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / secondary. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / secondary. Pancreatic Pseudocyst / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Tomography, X-Ray Computed

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  • (PMID = 16323569.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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78. Saito J, Takayama H, Kakuta Y, Miyagawa Y, Tsujihata M, Nishimura K, Nonomura N, Okuyama A: [The growing teratoma syndrome report of a case]. Nihon Hinyokika Gakkai Zasshi; 2006 Sep;97(6):796-800
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  • Histopathological examination of the specimen revealed yolk sac tumor and mature teratoma.
  • [MeSH-major] Endodermal Sinus Tumor. Neoplasms, Multiple Primary. Teratoma. Testicular Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Orchiectomy. Remission Induction

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  • (PMID = 17025213.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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79. Kandori S, Kawai K, Fukuhara Y, Joraku A, Miyanaga N, Shimazui T, Akaza H: A case of metastatic testicular cancer complicated by pulmonary hemorrhage due to choriocarcinoma syndrome. Int J Clin Oncol; 2010 Dec;15(6):611-4
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  • The pathological diagnosis of the surgical specimen was yolk sac carcinoma.
  • [MeSH-major] Brain Neoplasms / secondary. Choriocarcinoma / complications. Endodermal Sinus Tumor / pathology. Hemorrhage / etiology. Lung Diseases / etiology. Lung Neoplasms / secondary. Testicular Neoplasms / complications
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Prognosis. Syndrome


80. Palmer RD, Barbosa-Morais NL, Gooding EL, Muralidhar B, Thornton CM, Pett MR, Roberts I, Schneider DT, Thorne N, Tavaré S, Nicholson JC, Coleman N, Children's Cancer and Leukaemia Group: Pediatric malignant germ cell tumors show characteristic transcriptome profiles. Cancer Res; 2008 Jun 01;68(11):4239-47
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  • They vary substantially in their natural history and show important clinical differences from their adult counterparts.
  • To address the biological basis for these observations, we have undertaken a comprehensive analysis of global gene expression patterns in pediatric malignant GCTs and compared these findings with published data on adult testicular GCTs (TGCT).
  • Our study included 27 primary tumors and assessed the principal malignant histologic types of pediatric GCT, yolk sac tumor (YST; n = 18), and seminoma (n = 9).
  • In contrast, there was segregation of pediatric malignant GCTs and adult malignant TGCTs, most notably for the YSTs.
  • [MeSH-major] Endodermal Sinus Tumor / genetics. Gene Expression Profiling. Neoplasms, Germ Cell and Embryonal / genetics. RNA, Messenger / genetics. Seminoma / genetics

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  • (PMID = 18519683.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE10615
  • [Grant] United Kingdom / Medical Research Council / / MRC/ MC/ U105359875; United Kingdom / Cancer Research UK / / ; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger
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81. Jin JS, Hsieh DS, Loh SH, Chen A, Yao CW, Yen CY: Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. Mod Pathol; 2006 Mar;19(3):447-52
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  • Matriptase is a type II transmembrane serine protease expressed by cells of surface epithelial origin, including epithelial ovarian tumor cells.
  • Immunohistochemical analysis of matriptase was performed in tissue microarrays of 164 ovarian neoplasms including 84 serous adenocarcinomas, 23 mucinous adenocarcinomas, 10 endometrioid adenocarcinomas, six yolk sac tumors, 12 clear cell carcinomas, six dysgerminomas, eight granulosa cell tumors, four transitional cell carcinomas, five fibromas, and six Brenner tumors.
  • The matriptase scores were significantly higher in the tumors than in their nontumor counterparts (304+/-26 for serous adenocarcinoma; 361+/-28 for mucinous adenocarcinoma; 254+/-17 for endometrioid adenocarcinoma; 205+/-19 for yolk sac tumor; 162+/-16 for clear cell carcinoma; 109+/-11 for dysgerminoma; 105+/-9 for granulosa cell tumor; and 226+/-18 for transitional cell carcinoma).
  • [MeSH-minor] Adenocarcinoma, Clear Cell / enzymology. Adenocarcinoma, Clear Cell / pathology. Adult. Brenner Tumor / enzymology. Brenner Tumor / pathology. Carcinoma, Endometrioid / enzymology. Carcinoma, Endometrioid / pathology. Carcinoma, Transitional Cell / enzymology. Carcinoma, Transitional Cell / pathology. Child. Cystadenocarcinoma, Mucinous / enzymology. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Serous / enzymology. Cystadenocarcinoma, Serous / pathology. Dysgerminoma / enzymology. Dysgerminoma / pathology. Endodermal Sinus Tumor / enzymology. Endodermal Sinus Tumor / pathology. Female. Fibroma / enzymology. Fibroma / pathology. Humans. Immunohistochemistry. Middle Aged. Tissue Array Analysis / methods

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  • (PMID = 16439987.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.109 / ST14 protein, human
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82. Soleymani Majd H, Turner SA, Choji K, Lwin K, B-Lynch C: Acute abdomen secondary to rare yolk sac tumour. Arch Gynecol Obstet; 2009 May;279(5):725-7
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  • [Title] Acute abdomen secondary to rare yolk sac tumour.
  • An emergency laparotomy was performed and she required a pelvic clearance for a Stage IIB ovarian tumour, later confirmed as a yolk sac tumour.
  • Accurate staging and tumour-reductive surgery strongly affects the prognosis of yolk sac tumours.
  • [MeSH-major] Abdomen, Acute / etiology. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Centralized Hospital Services. Clinical Competence. Female. Great Britain. Humans. Hysterectomy. Lymph Node Excision. Neoplasm Staging. Omentum / pathology. Omentum / surgery. Ovariectomy. Referral and Consultation. Rupture, Spontaneous / surgery. Tomography, X-Ray Computed

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  • (PMID = 18795306.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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83. Guillem V, Poveda A: Germ cell tumours of the ovary. Clin Transl Oncol; 2007 Apr;9(4):237-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor. Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / pathology. Child. Choriocarcinoma / diagnosis. Choriocarcinoma / drug therapy. Choriocarcinoma / pathology. Chorionic Gonadotropin, beta Subunit, Human. Dysgerminoma / diagnosis. Dysgerminoma / drug therapy. Dysgerminoma / pathology. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / pathology. Female. Humans. Neoplasm Staging. Ovary / pathology. Prognosis. Randomized Controlled Trials as Topic. Teratoma / diagnosis. Teratoma / drug therapy. Teratoma / pathology. World Health Organization. alpha-Fetoproteins

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  • (PMID = 17462976.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
  • [Number-of-references] 49
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84. Wedrychowicz A, Spodaryk M, Krasowska-Kwiecień A, Goździk J: Total parenteral nutrition in children and adolescents treated with high-dose chemotherapy followed by autologous haematopoietic transplants. Br J Nutr; 2010 Mar;103(6):899-906
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Calcium / administration & dosage. Child. Child, Preschool. Endodermal Sinus Tumor / therapy. Female. Hodgkin Disease / therapy. Humans. Infant. Magnesium / administration & dosage. Male. Neuroblastoma / therapy. Nutritional Status. Potassium / administration & dosage. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy. Sarcoma, Ewing / therapy. Transplantation, Autologous. Treatment Outcome. Young Adult

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  • (PMID = 19860986.001).
  • [ISSN] 1475-2662
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] I38ZP9992A / Magnesium; RWP5GA015D / Potassium; SY7Q814VUP / Calcium
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85. Han JY, Nava-Ocampo AA, Kim TJ, Shim JU, Park CT: Pregnancy outcome after prenatal exposure to bleomycin, etoposide and cisplatin for malignant ovarian germ cell tumors: report of 2 cases. Reprod Toxicol; 2005 Mar-Apr;19(4):557-61
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  • A pregnant woman with a stage Ic yolk-sac tumor underwent a right oophorectomy with omentectomy, and received five cycles of bleomycin, etoposide and cisplatin from the 22nd week of pregnancy until delivery.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endodermal Sinus Tumor / drug therapy. Ovarian Neoplasms / drug therapy. Pregnancy Complications, Neoplastic / drug therapy. Pregnancy Outcome. Teratoma / drug therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Bleomycin / adverse effects. Bleomycin / therapeutic use. Cisplatin / administration & dosage. Cisplatin / adverse effects. Cisplatin / therapeutic use. Etoposide / administration & dosage. Etoposide / adverse effects. Etoposide / therapeutic use. Female. Humans. Infant, Newborn. Male. Pregnancy

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  • (PMID = 15749271.001).
  • [ISSN] 0890-6238
  • [Journal-full-title] Reproductive toxicology (Elmsford, N.Y.)
  • [ISO-abbreviation] Reprod. Toxicol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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86. Ghaemmaghami F, Hasanzadeh M: Good fetal outcome of pregnancies with gynecologic cancer conditions: cases and literature review. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:225-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Endodermal Sinus Tumor / therapy. Ovarian Neoplasms / therapy. Pregnancy Complications, Neoplastic / therapy. Vulvar Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Fatal Outcome. Female. Gynecologic Surgical Procedures. Humans. Pregnancy. Pregnancy Outcome. Treatment Failure. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 16515595.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
  • [Number-of-references] 29
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87. Cicin I, Saip P, Guney N, Eralp Y, Ayan I, Kebudi R, Topuz E: Yolk sac tumours of the ovary: evaluation of clinicopathological features and prognostic factors. Eur J Obstet Gynecol Reprod Biol; 2009 Oct;146(2):210-4
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  • [Title] Yolk sac tumours of the ovary: evaluation of clinicopathological features and prognostic factors.
  • OBJECTIVE: To evaluate the clinicopathological prognostic features, factors and outcomes of chemotherapy in ovarian yolk sac tumours (YST).
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Child. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Female. Follow-Up Studies. Humans. Hysterectomy. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Ovariectomy. Prognosis. Retrospective Studies. Risk Factors. Treatment Outcome. Young Adult

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  • (PMID = 19419810.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Ireland
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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88. Duan G, Xu YK, Dai L, Zhang XD: [CT diagnosis and pathological findings of testicular lesion]. Nan Fang Yi Ke Da Xue Xue Bao; 2007 Jan;27(1):98-100
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  • METHODS: In patients with testicular space-occupying lesions, 11 underwent examinations for such tumor markers as alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG).
  • RESULTS: Of the 13 patients, histopathologically confirmed seminoma was found in 3, endodermal sinus tumor in 1, teratoma in 2, mixed germinoma in 2, leucoma in 1 case, abscess in 2, and tuberculosis in 2.
  • CONCLUSION: CT scan in combination with the clinical analysis and tumor marker examinations can be of important value in the diagnosis and differential diagnosis of testicular space-occupying lesions.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chorionic Gonadotropin / analysis. Histocytochemistry. Humans. Male. Reproducibility of Results. Seminoma / diagnosis. Seminoma / metabolism. Seminoma / radiography. Sensitivity and Specificity. alpha-Fetoproteins / analysis

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  • (PMID = 17259159.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin; 0 / alpha-Fetoproteins
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89. Fritsch MK, Schneider DT, Schuster AE, Murdoch FE, Perlman EJ: Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors. Pediatr Dev Pathol; 2006 Mar-Apr;9(2):115-31
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  • The molecular signaling pathways mediating human germ cell tumor (GCT) formation and progression are poorly understood despite a large number of studies detailing recurrent cytogenetic abnormalities.
  • Germ cell tumors consist of multiple histologic subtypes and can also be divided into infantile/childhood or adolescent/adult tumors as well as gonadal or nongonadal sites of origin.
  • We utilized complementary DNA (cDNA) microarray analysis to identify differences in signal transduction pathways between 2 histologic subtypes of malignant ovarian GCTs (dysgerminomas versus ovarian endodermal sinus tumors).
  • Hierarchical cluster analysis using only the genes involved in Wnt/beta-catenin signaling was able to distinguish these 2 tumor subtypes from each other.
  • Wnt13 and beta-catenin showed significant differential expression patterns between the 2 tumor subtypes, and the results were confirmed by semiquantitative reverse transcriptase-polymerase chain reaction.
  • Finally, we prepared tissue microarrays containing GCTs from 83 different patients and demonstrated high levels of beta-catenin protein expression in 100% and nuclear accumulation in approximately 50% to 70% of all endodermal sinus tumors and immature teratomas (ITs).
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Gene Expression Profiling. Humans. Infant. Male. Oligonucleotide Array Sequence Analysis. RNA, Messenger / metabolism. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction. Tissue Array Analysis

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  • (PMID = 16822086.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Wnt Proteins; 0 / beta Catenin
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90. Nishio S, Ushijima K, Fukui A, Fujiyoshi N, Kawano K, Komai K, Ota S, Fujiyoshi K, Kamura T: Fertility-preserving treatment for patients with malignant germ cell tumors of the ovary. J Obstet Gynaecol Res; 2006 Aug;32(4):416-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thirty-five patients were included in the study, 14 with immature teratoma, 11 with dysgerminoma, eight with endodermal sinus tumor, and two with mixed germ cell tumor.
  • She was 13 years old with a stage IV endodermal sinus tumor.
  • [MeSH-minor] Adolescent. Adult. Child. Female. Fertility. Follow-Up Studies. Humans. Ovariectomy

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  • (PMID = 16882268.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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91. Lai CH, Chang TC, Hsueh S, Wu TI, Chao A, Chou HH, Wang PN: Outcome and prognostic factors in ovarian germ cell malignancies. Gynecol Oncol; 2005 Mar;96(3):784-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The clinicopathological and treatment-related characteristics were analyzed for association with the occurrence of tumor persistence/recurrence or death.
  • RESULTS: Of the study patients, 32 had dysgerminoma (DSG), 29 immature teratoma (IMT), 23 endodermal sinus tumor, 7 mixed germ cell tumors, and 1 each had choriocarcinoma and embryonal carcinoma.
  • Histology (DSG/IMT versus non-DSG/IMT) (P < 0.0001) and International Federation of Gynecology and Obstetrics stage (P = 0.001) were significantly associated with treatment failure, while histology (P = 0.0004), salvage high-dose chemotherapy (HD-CT) after primary chemotherapy failed (P = 0.0405), and residual tumor after salvage surgery (P = 0.0014) were significant prognostic factors for overall survival.
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Female. Humans. Middle Aged. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prognosis. Retrospective Studies. Salvage Therapy. Treatment Outcome

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  • (PMID = 15721426.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT, Korean Gynecologic Oncology Group: Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study. Int J Gynecol Cancer; 2009 Jan;19(1):84-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, immature teratoma was the most common tumor type (n = 68), followed by dysgerminoma (n = 54), endodermal sinus tumor (n = 38), mixed form (n = 24), and choriocarcinoma (n = 12).
  • Recurrence was observed in 13 patients (6.8%) and was influenced by the stage of the tumor and patient age (>40 years).
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Korea. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 19258947.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Lee JK; Park JJ; Cha MS; Kim JH; Lee JM; Park SY; Kim SC; Lee SK
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93. Li J, Yang W, Wu X: Prognostic factors and role of salvage surgery in chemorefractory ovarian germ cell malignancies: a study in Chinese patients. Gynecol Oncol; 2007 Jun;105(3):769-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The histological subtypes included 2 dysgerminomas (DSG), 7 immature teratomas (IMT), 22 endodermal sinus tumors (EST) (including 16 pure EST, 3 mixed type with DSG, 3 with EC), 2 embryonal carcinomas (EC) and 1 mixed form (with component of sex cord-stromal tumor).
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. China. Cisplatin / administration & dosage. Drug Resistance, Neoplasm. Etoposide / administration & dosage. Female. Humans. Multivariate Analysis. Prognosis. Retrospective Studies. Salvage Therapy. Vinblastine / administration & dosage

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  • Hazardous Substances Data Bank. BLEOMYCIN .
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  • (PMID = 17459461.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol; PVB protocol
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94. Lovrić E, Hizak DB, Balja MP, Lenicek T, Kruslin B: An unusual mixed germ cell tumor of the testis consisting of rhabdomyosarcoma, mature teratoma and yolk sac tumor. Asian J Androl; 2010 May;12(3):451-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual mixed germ cell tumor of the testis consisting of rhabdomyosarcoma, mature teratoma and yolk sac tumor.
  • [MeSH-major] Endodermal Sinus Tumor / pathology. Neoplasms, Multiple Primary / pathology. Rhabdomyosarcoma / pathology. Teratoma / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Desmin / analysis. Humans. Male. Treatment Outcome

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  • [Cites] Ann Oncol. 2002 Feb;13(2):323-6 [11886012.001]
  • [Cites] J Pathol. 2009 Jun;218(2):146-62 [19253916.001]
  • [Cites] APMIS. 2007 Nov;115(11):1296-301 [18092964.001]
  • [Cites] Int J Cancer. 2006 Jun 15;118(12):3099-111 [16395710.001]
  • (PMID = 20173766.001).
  • [ISSN] 1745-7262
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin
  • [Other-IDs] NLM/ PMC3739272
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95. Hira HS, Shukla A, Chhabra G, Saran RK: Yolk sac tumor and Horner's syndrome-a case report. J Thorac Oncol; 2010 Jun;5(6):917-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Yolk sac tumor and Horner's syndrome-a case report.
  • [MeSH-major] Endodermal Sinus Tumor / complications. Horner Syndrome / etiology. Lung Neoplasms / complications
  • [MeSH-minor] Adult. Humans. Male. alpha-Fetoproteins / analysis

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  • (PMID = 20502271.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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96. Ohno M, Narita Y: A case of pathological complete remission of a brain metastasis from germ cell tumor of the testis after systemic chemotherapy. Jpn J Clin Oncol; 2010 Dec;40(12):1201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pathological complete remission of a brain metastasis from germ cell tumor of the testis after systemic chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Choriocarcinoma / drug therapy. Endodermal Sinus Tumor / drug therapy. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Chorionic Gonadotropin, beta Subunit, Human / blood. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Male. Remission Induction. Tomography, X-Ray Computed

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  • (PMID = 21112974.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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97. Droz JP: [Classification of germ cell tumors of the testis]. Rev Prat; 2007 Feb 28;57(4):375-8
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Carcinoma, Embryonal / pathology. Child. Child, Preschool. Endodermal Sinus Tumor / pathology. Humans. Male. Neoplasm Regression, Spontaneous. Neoplasm Staging. Prognosis. Seminoma / pathology. World Health Organization

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  • (PMID = 17506214.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
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98. Zhu YL, Yang YP, Zhang JM: [Diffuse embryoma of the testis: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2010 Feb;39(2):118-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Embryonal / pathology. Endodermal Sinus Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD30 / metabolism. Diagnosis, Differential. Humans. Keratin-19 / metabolism. Male. Orchiectomy / methods. alpha-Fetoproteins / metabolism

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  • (PMID = 20388380.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Keratin-19; 0 / alpha-Fetoproteins
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99. Verma M, Al Hakim A, Berney D: Late recurrence of an ovarian yolk sac tumour as a carcinosarcoma. Pathology; 2007 Dec;39(6):601-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late recurrence of an ovarian yolk sac tumour as a carcinosarcoma.
  • [MeSH-major] Carcinosarcoma / pathology. Endodermal Sinus Tumor / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Fallopian Tubes / pathology. Fallopian Tubes / surgery. Fatal Outcome. Female. Humans

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  • (PMID = 18027268.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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100. Ikdahl T, Josefsen D, Jakobsen E, Delabie J, Fosså SD: Concurrent mediastinal germ-cell tumour and haematological malignancy: case report and short review of literature. Acta Oncol; 2008;47(3):466-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Carcinoma, Embryonal / complications. Carcinoma, Embryonal / pathology. Chest Pain / etiology. Cough / etiology. Endodermal Sinus Tumor / complications. Endodermal Sinus Tumor / pathology. Fatal Outcome. Fatigue / etiology. Fever / etiology. Gastrointestinal Hemorrhage / etiology. Humans. Leukemic Infiltration. Male. Teratocarcinoma / pathology. Teratoma / complications. Teratoma / pathology. Testis / pathology

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  • (PMID = 18348004.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Norway
  • [Number-of-references] 12
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