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1. Zada G, Laws ER: Surgical management of craniopharyngiomas in the pediatric population. Horm Res Paediatr; 2010;74(1):62-6
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  • [Title] Surgical management of craniopharyngiomas in the pediatric population.
  • BACKGROUND: Craniopharyngiomas (CPs) are benign, locally aggressive neoplasms that comprise approximately 10% of pediatric brain tumors.
  • CONCLUSION: Consistent longitudinal management by an interdisciplinary team can alter the treatment course in patients with CPs from a debilitating, morbid or lethal condition to a chronic, survivable disease with functional adult livelihood.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20453478.001).
  • [ISSN] 1663-2826
  • [Journal-full-title] Hormone research in pædiatrics
  • [ISO-abbreviation] Horm Res Paediatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
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2. Schittenhelm J, Psaras T, Meyermann R, Honegger J, Beschorner R: Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. Folia Neuropathol; 2010;48(2):75-80
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  • [Title] Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms.
  • While many neoplasms have been studied, to date, no data is available on CDX2 expression in craniopharyngiomas.
  • MATERIAL AND METHODS: We investigated CDX2 expression in 28 normal pituitary glands, 75 pituitary adenomas of varying hormonal activity (including 7 invasive adenomas and 7 atypical adenomas) and 23 craniopharyngiomas (17 adamantinous and 6 papillary) in tissue microarrays.
  • RESULTS: None of the pituitary adenomas, craniopharyngiomas and normal pituitary glands showed expression of CDX2.
  • CONCLUSIONS: There is no evidence for that CDX2 might play a role in tumourigenesis, invasive growth or tumour recurrence of pituitary adenomas or in tumourigenesis of craniopharyngiomas.

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  • (PMID = 20602288.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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3. Shahzadi S, Sharifi G, Andalibi R, Zali A, Ali-Asgari A: Management of cystic craniopharyngiomas with intracavitary irradiation with 32P. Arch Iran Med; 2008 Jan;11(1):30-4
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  • [Title] Management of cystic craniopharyngiomas with intracavitary irradiation with 32P.
  • BACKGROUND: Cystic craniopharyngiomas are the most frequent intracranial neoplasm of nonglial origin in children.
  • Follow-up data were analyzed to assess the value of intracavitary irradiation with stereotactically applied 32P radioisotopes for the treatment of patients with craniopharyngioma cysts admitted to Shohada Tajrish Hospital, Tehran, Iran, between 1998 and 2005.
  • METHODS: Patients with predominantly cystic craniopharyngiomas, who underwent stereotactic intracavitary irradiation, were followed for tumor response and complications.
  • Beta-emitting 32P isotopes were injected into cysts using a computed tomography-guided and computer-assisted three-dimensional stereotactic treatment planning and application system.
  • The tumor response rate gained with 32P-labeled chromic phosphate was 73% (16 of 22 cysts).
  • CONCLUSION: Intracavitary irradiation using 32P is highly effective in the treatment of cystic craniopharyngiomas.
  • [MeSH-major] Brachytherapy / methods. Craniopharyngioma / radiotherapy. Cysts / radiotherapy. Pituitary Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Phosphorus Radioisotopes / therapeutic use. Stereotaxic Techniques. Treatment Outcome

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  • (PMID = 18154420.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Chemical-registry-number] 0 / Phosphorus Radioisotopes
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4. Jiang ZL, Ren XH, Chu JS, Lin S, Zhang MZ: [Microsurgical treatment of adult craniopharyngiomas in 156 cases]. Zhonghua Yi Xue Za Zhi; 2010 Feb 2;90(5):291-4
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  • [Title] [Microsurgical treatment of adult craniopharyngiomas in 156 cases].
  • OBJECTIVE: To explore the clinical features, surgical approaches and outcomes of craniopharyngioma in adults.
  • METHODS: A total of 156 cases of adult craniopharyngioma underwent microsurgery at our hospital were retrospectively reviewed and classified into four types according to the location of tumor relative to sellar diaphragm and the third ventricle.
  • 75.3% of the cases were capable of normal work and life and tumor recurred in 26 cases.
  • CONCLUSION: Selection of appropriate approach is the key to successful microsurgery for craniopharyngioma according to the site and growth pattern of tumor.
  • [MeSH-major] Craniopharyngioma / surgery. Microsurgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20368046.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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5. Combs SE, Thilmann C, Huber PE, Hoess A, Debus J, Schulz-Ertner D: Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy. Cancer; 2007 Jun 1;109(11):2308-14
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  • [Title] Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy.
  • BACKGROUND: The long-term outcome in patients with craniopharyngiomas treated with fractionated stereotactic radiotherapy (FSRT) was evaluated.
  • METHODS: A total of 40 patients with craniopharyngiomas were treated between May 1989 and July 2006 with FSRT.
  • Most patients were treated for tumor progression after surgery.
  • CONCLUSIONS: The long-term outcome of FSRT for craniopharyngiomas is excellent with regard to local control as well as treatment-related side effects.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiotherapy / methods. Stereotaxic Techniques
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17469176.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Okinaga H, Matsuno A, Okazaki R: High risk of osteopenia and bone derangement in postsurgical patients with craniopharyngiomas, pituitary adenomas and other parasellar lesions. Endocr J; 2005 Dec;52(6):751-6
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  • [Title] High risk of osteopenia and bone derangement in postsurgical patients with craniopharyngiomas, pituitary adenomas and other parasellar lesions.
  • We measured bone mineral density (BMD) and urinary type I collagen N-telopeptide (uNTX) in 35 postoperative patients including 25 with pituitary tumor (PT), 6 with craniopharyngioma (CP), and 4 others who had not been on sex hormone replacement, raloxifene, or bisphosphonate therapy.
  • Five out of 6 patients with CP had BMD lower than 80% of young adult mean (YAM), whereas 11 out of 22 patients with PT had BMD less than 80% of YAM.
  • [MeSH-major] Bone Density. Bone Diseases, Metabolic / etiology. Bone Resorption / etiology. Craniopharyngioma / surgery. Hypopituitarism / complications. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Collagen / urine. Collagen Type I. Diphosphonates / pharmacology. Diphosphonates / therapeutic use. Estrogens / blood. Female. Follicle Stimulating Hormone / blood. Gonadotropins / blood. Humans. Hydrocortisone / pharmacology. Hydrocortisone / therapeutic use. Luteinizing Hormone / blood. Male. Middle Aged. Peptides / urine. Raloxifene Hydrochloride / pharmacology. Raloxifene Hydrochloride / therapeutic use. Risk Factors. Testosterone / blood. Thyroxine / pharmacology. Thyroxine / therapeutic use

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  • (PMID = 16410668.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Diphosphonates; 0 / Estrogens; 0 / Gonadotropins; 0 / Peptides; 0 / collagen type I trimeric cross-linked peptide; 3XMK78S47O / Testosterone; 4F86W47BR6 / Raloxifene Hydrochloride; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone; 9007-34-5 / Collagen; Q51BO43MG4 / Thyroxine; WI4X0X7BPJ / Hydrocortisone
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7. Luo S, Pan J, Qi ST, Fang LX, Fan J, Liu BG: [Analysis of the factors contributing to diabetes insipidus after surgeries for craniopharyngiomas]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Mar;29(3):544-7
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  • [Title] [Analysis of the factors contributing to diabetes insipidus after surgeries for craniopharyngiomas].
  • OBJECTIVE: To analyze the factors contributing to the occurrence of diabetes insipidus after operations for craniopharyngiomas.
  • METHODS: A total of 121 cases of diabetes insipidus following surgeries for craniopharyngiomas were retrospectively analyzed and the factors associated with postoperative diabetes insipidus were analyzed.
  • The occurrence of early postoperative diabetes insipidus showed a significant relation to the classification and calcification of the craniopharyngioma.
  • Late postoperative diabetes insipidus was closely correlated to such factors as age, classification of craniopharyngioma, and intraoperative treatment of the pituitary stalk, but not to the scope of tumor resection or tumor calcification.
  • CONCLUSIONS: Postoperative diabetes insipidus following surgeries for craniopharyngiomas is closely related to the tumor classification, calcification and pituitary stalk protection.
  • [MeSH-major] Craniopharyngioma / surgery. Diabetes Insipidus / etiology. Pituitary Neoplasms / surgery. Postoperative Complications / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. China / epidemiology. Female. Humans. Incidence. Infant. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Regression Analysis. Retrospective Studies. Sella Turcica. Young Adult


8. Jane JA Jr, Kiehna E, Payne SC, Early SV, Laws ER Jr: Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas. Neurosurg Focus; 2010 Apr;28(4):E9
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  • [Title] Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas.
  • OBJECT: Although the transsphenoidal approach for subdiaphragmatic craniopharyngiomas has been performed for many years, there are few reports describing the role of the endoscopic transsphenoidal technique for suprasellar craniopharyngiomas.
  • The purpose of this study was to report the outcomes of the endoscopic transsphenoidal approach for adults with craniopharyngiomas in whom the goal was gross-total resection.
  • CONCLUSIONS: The authors have achieved a high rate of radical resection and symptomatic improvement with the endoscopic transsphenoidal technique for both subdiaphragmatic (sellar/suprasellar) and supradiaphragmatic (suprasellar) craniopharyngiomas.
  • Endoscopic assessment of tumor resection may be more sensitive for residual tumor than the first postoperative MR imaging study.
  • [MeSH-major] Craniopharyngioma / surgery. Neuroendoscopy / methods. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Diabetes Insipidus / etiology. Female. Humans. Hypopituitarism / etiology. Magnetic Resonance Imaging. Male. Microsurgery / methods. Middle Aged. Postoperative Complications / etiology. Sella Turcica / pathology. Sella Turcica / surgery. Sphenoid Sinus. Treatment Outcome. Tumor Burden. Vision Disorders / etiology

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  • (PMID = 20367523.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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9. Van Gompel JJ, Nippoldt TB, Higgins DM, Meyer FB: Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity. Neurosurg Focus; 2010 Apr;28(4):E3
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  • [Title] Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity.
  • OBJECT: Obesity as a consequence of management of pediatric craniopharyngioma is a well-described phenomenon related to the degree of hypothalamic involvement.
  • However, weight change and obesity have not been analyzed in adult patients.
  • Therefore, the purpose of this study was 1) to evaluate the pattern of postoperative weight gain related to preoperative body mass index (BMI), 2) determine if postoperative weight gain is an issue in adult patients, and 3) develop an objective MR imaging grading system to predict risk of postoperative weight gain and obesity in adults treated for craniopharyngioma.
  • METHODS: The authors retrospectively screened 296 patients with known craniopharyngioma for the following inclusion criteria: pathologically confirmed craniopharyngioma, index surgery at the authors' institution, and operative weight and height recorded with at least 3 months of follow-up including body weight measurement.
  • Cases of craniopharyngiomas were compared with age- and sex-matched controls (pituitary adenoma patients) to evaluate the pattern and significance of perioperative weight changes.
  • Comparing craniopharyngioma patients (cases) to age- and sex-matched controls, the preoperative BMIs were similar (p = 0.93) between cases (mean 28.9 [95% CI 30.9-26.9]) and controls (mean 29.3 [95% CI 31.9-26.7]).
  • CONCLUSIONS: Postoperative weight gain in adult patients undergoing surgery for craniopharyngioma is a significant problem and correlates with hypothalamic involvement, as it does in pediatric patients.
  • [MeSH-major] Craniopharyngioma / surgery. Magnetic Resonance Imaging / statistics & numerical data. Obesity / diagnosis. Pituitary Neoplasms / surgery. Postoperative Complications / diagnosis
  • [MeSH-minor] Adolescent. Adult. Age Factors. Body Mass Index. Female. Follow-Up Studies. Humans. Hypophysectomy / methods. Hypothalamus / pathology. Hypothalamus / surgery. Male. Preoperative Care. Retrospective Studies. Risk Factors. Weight Gain

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  • (PMID = 20367360.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024150
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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10. Jung TY, Jung S, Choi JE, Moon KS, Kim IY, Kang SS: Adult craniopharyngiomas: surgical results with a special focus on endocrinological outcomes and recurrence according to pituitary stalk preservation. J Neurosurg; 2009 Sep;111(3):572-7
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  • [Title] Adult craniopharyngiomas: surgical results with a special focus on endocrinological outcomes and recurrence according to pituitary stalk preservation.
  • OBJECT: The aim of this study was to evaluate the results of surgical treatment of adult craniopharyngioma with a special focus on the endocrinological outcomes and tumor recurrence in cases of pituitary preservation.
  • METHODS: Between 1993 and February 2008, 41 patients underwent 47 surgical procedures for craniopharyngioma.
  • The tumor was totally removed in 36 procedures (76.6%), subtotally in 10 (21.3%), and partially in 1 (2.1%).
  • The rate of tumor recurrence was 24.4%.
  • The recurrence-free survival rate was significantly different between patients in whom complete tumor resection was accomplished and those in whom tumor resection was incomplete.
  • CONCLUSIONS: The pituitary stalk must be preserved with maximal tumor resection whenever possible to increase the chance of intact anterior pituitary function being maintained.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Gland. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Postoperative Complications. Vision Disorders / etiology

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  • (PMID = 19361259.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Karavitaki N, Wass JA: Craniopharyngiomas. Endocrinol Metab Clin North Am; 2008 Mar;37(1):173-93, ix-x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngiomas.
  • Craniopharyngiomas are epithelial tumors arising along the path of the craniopharyngeal duct and presenting with a variety of manifestations.
  • Craniopharyngiomas are associated with significant long-term morbidity and mortality rates.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adult. Brachytherapy. Child. Humans. Radiosurgery

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  • (PMID = 18226736.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 132
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12. Karavitaki N, Cudlip S, Adams CB, Wass JA: Craniopharyngiomas. Endocr Rev; 2006 Jun;27(4):371-97
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  • [Title] Craniopharyngiomas.
  • Craniopharyngiomas are rare, mainly sellar/parasellar, epithelial tumors diagnosed during childhood or adult life.
  • Currently, surgical excision followed by external beam irradiation, in cases of residual tumor, is the main treatment option.
  • The central registration of patients with these challenging tumors may provide correlates between treatments and outcomes and establish prognostic factors at the pathological or molecular level that may further guide us in the future.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / adverse effects. Bleomycin / therapeutic use. Cognition Disorders / etiology. Humans. Hypothalamic Diseases / etiology. Neoplasm Recurrence, Local / etiology. Radiotherapy / adverse effects. Radiotherapy / methods

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  • (PMID = 16543382.001).
  • [ISSN] 0163-769X
  • [Journal-full-title] Endocrine reviews
  • [ISO-abbreviation] Endocr. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
  • [Number-of-references] 256
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13. Karavitaki N: Hypopituitarism oddities: craniopharyngiomas. Horm Res; 2007;68 Suppl 5:151-3
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  • [Title] Hypopituitarism oddities: craniopharyngiomas.
  • Craniopharyngiomas are tumours associated with significant long-term pituitary dysfunction.
  • The rates of anterior pituitary hormone deficits are not influenced by treatment modality and do not differ between childhood- and adult-onset disease.
  • GH replacement therapy offers significant benefits for both children and adults (although adult patients are less likely to lose weight or body fat).
  • [MeSH-major] Craniopharyngioma / complications. Hypopituitarism / etiology. Pituitary Neoplasms / complications
  • [MeSH-minor] Growth Hormone / therapeutic use. Hormone Replacement Therapy. Hormones / deficiency. Humans. Neoplasm Recurrence, Local. Risk Assessment

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 18174734.001).
  • [ISSN] 1423-0046
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Hormones; 9002-72-6 / Growth Hormone
  • [Number-of-references] 13
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14. [Craniopharyngiomas in the adults]. Arkh Patol; 2005 Jul-Aug;67(4):41-5
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  • [Title] [Craniopharyngiomas in the adults].
  • Craniopharyngiomas (CP) were studied morphologically (52 cases), immunohistochemically (6 cases) and molecular-genetically (5 cases) in patients aged 18-65 years.
  • [MeSH-major] Biomarkers, Tumor / analysis. Craniopharyngioma / diagnosis. Craniopharyngioma / mortality. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Mutation

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  • (PMID = 16209298.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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15. Yamini B, Narayanan M: Craniopharyngiomas: an update. Expert Rev Anticancer Ther; 2006 Sep;6 Suppl 9:S85-92
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  • [Title] Craniopharyngiomas: an update.
  • Craniopharyngiomas have been challenging practitioners for over 100 years.
  • They are rare tumors found in both the adult and pediatric populations.
  • Patients in general have high long-term survival but can have significant tumor- and treatment-associated morbidity requiring a lifetime of medical and psychological management.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery

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  • (PMID = 17004862.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 58
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16. Baldé NM, Diallo MM, Poirier JY, Sow MS, Brassier G, Lorcy Y: [Long-term outcome of the adult onset craniopharyngiomas]. Ann Endocrinol (Paris); 2007 Jun;68(2-3):186-90
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  • [Title] [Long-term outcome of the adult onset craniopharyngiomas].
  • [Transliterated title] Devenir à long-terme des craniopharyngiomes de l'adulte.
  • There is few published series dealing on the long-term outcome of the adult-onset craniopharyngiomas.
  • We report the long term clinical, tomodensitometric and MRI data outcome of 35 (23 woman and 12 men) consecutive adult-onset cured for craniopharyngiomas between 1983 and 2002, and followed-up in Rennes University Hospital.
  • Recurrence of tumour occurred in 8 patients (25.8%) and a tumor progression in 1 case.
  • Two patients had 5 and 6 years treatment by growth hormone (GH), without tumor recurrence.
  • The observed increase of weight after the surgical cure of craniopharyngiomas concerned 22 patients (63%).
  • In conclusion the craniopharyngiomas recurrence is frequent and can appear in very prolonged deadlines after the initial surgery.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Growth Hormone / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Mental Disorders / etiology. Middle Aged. Neoplasm Recurrence, Local. Survival Analysis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17531946.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 9002-72-6 / Growth Hormone
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17. Kawamata T, Kubo O, Hori T: Histological findings at the boundary of craniopharyngiomas. Brain Tumor Pathol; 2005;22(2):75-8
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  • [Title] Histological findings at the boundary of craniopharyngiomas.
  • Although a craniopharyngioma is grossly well circumscribed, microscopically the borders are frequently irregular and may be associated with gliosis in the adjacent brain tissue.
  • In the current study, we investigated the histology of the interface between craniopharyngiomas and surrounding normal structures such as the hypothalamus and pituitary gland.
  • Histologically, we classified the findings at the boundary of craniopharyngiomas into three types.
  • In type 1, a relatively thick capsule-like tissue was identified at the boundary between the craniopharyngioma and surrounding normal structure composed of tumor cells and inflammatory changes.
  • In type 2, a craniopharyngioma had a relatively clear cleavage between the surrounding gliosis.
  • In type 3, the boundary had some interdigitation of the tumor in the surrounding gliotic layer adjacent to the craniopharyngioma.
  • In types 1 and 3, surgeons may fail to accomplish complete resection of the tumor.
  • These histological features may result in recurrence of craniopharyngioma even after gross total resection.
  • [MeSH-major] Craniopharyngioma / ultrastructure. Hypothalamus / ultrastructure. Pituitary Gland / ultrastructure. Pituitary Neoplasms / ultrastructure
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Stem / ultrastructure. Child. Child, Preschool. Female. Gliosis / etiology. Gliosis / pathology. Humans. Infant. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Visual Pathways / ultrastructure. Young Adult

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  • (PMID = 18095108.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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18. Oikonomou E, Barreto DC, Soares B, De Marco L, Buchfelder M, Adams EF: Beta-catenin mutations in craniopharyngiomas and pituitary adenomas. J Neurooncol; 2005 Jul;73(3):205-9
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  • [Title] Beta-catenin mutations in craniopharyngiomas and pituitary adenomas.
  • Craniopharyngiomas and pituitary adenomas are both tumors of the hypothalamic and pituitary region, respectively that are frequently associated with endocrine defects either because of direct involvement of hormone producing cells (most pituitary tumors) or because of secondary defects due to disturbance of hypothalamic function (some pituitary tumors and craniopharyngiomas).
  • Some studies suggest that mutant beta-catenin gene cells in craniopharyngiomas and pituitary adenomas contribute to their tumorigenesis.
  • Sequenced PCR products for possible beta-catenin gene mutations showed a total of 7/43 alterations in adamantinomatous craniopharyngioma-derived DNA samples.
  • None of the 22 pituitary adenomas and the eight papillary craniopharyngiomas analyzed presented any sequence alterations.
  • These findings demonstrate an association between beta-catenin gene alterations and craniopharyngiomas of the adamantinomatous type.
  • Since this gene product is involved with development, these results suggest that beta-catenin mutations may contribute to the initiation and subsequent growth of congenital craniopharyngiomas.
  • [MeSH-major] Adenoma / genetics. Craniopharyngioma / genetics. Cytoskeletal Proteins / genetics. Pituitary Neoplasms / genetics. Trans-Activators / genetics
  • [MeSH-minor] Adult. Base Sequence. Child. DNA Mutational Analysis. Female. Humans. Male. Middle Aged. Mutation. Polymerase Chain Reaction. beta Catenin

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  • (PMID = 15980970.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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19. Shirane R, Hayashi T, Tominaga T: Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern. Childs Nerv Syst; 2005 Aug;21(8-9):669-78
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  • [Title] Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern.
  • METHOD: Forty-two patients who were surgically treated for craniopharyngiomas extending outside the sellar-suprasellar region were evaluated.
  • CONCLUSION: In our experience, the fronto-basal interhemispheric approach, even through a small craniotomy window, is a valid choice for the removal of craniopharyngiomas extending outside the sellar-suprasellar region.
  • This approach offers a safe and minimally invasive means of treating craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Frontal Lobe / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery. Sella Turcica / surgery
  • [MeSH-minor] Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging / methods. Male. Middle Aged. Postoperative Period. Skull Base / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 16034620.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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20. Fahlbusch R, Hofmann BM: Surgical management of giant craniopharyngiomas. Acta Neurochir (Wien); 2008 Dec;150(12):1213-26
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  • [Title] Surgical management of giant craniopharyngiomas.
  • INTRODUCTION: Multimodal treatment in the management of giant craniopharyngiomas (>4 cm in diameter) is necessary to obtain optimal results, and includes conservative or palliative treatment and "aggressive" removal.
  • MATERIALS AND METHODS: Between January 1996 and January 2005 16 patients were diagnosed with giant craniopharyngiomas.
  • If hypothalamic disturbances are absent or improving due to pre-treatment (medical therapy, symptomatic surgery), giant craniopharyngiomas can be surgically removed in more than two of three patients with low morbidity and only moderate deterioration of endocrine function.
  • [MeSH-major] Craniopharyngioma / surgery. Microsurgery / methods. Neurosurgical Procedures / methods. Pituitary Gland / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Central Nervous System Cysts / etiology. Central Nervous System Cysts / pathology. Central Nervous System Cysts / surgery. Child. Clinical Protocols. Female. Hormone Replacement Therapy / methods. Humans. Hypothalamo-Hypophyseal System / physiopathology. Hypothalamo-Hypophyseal System / secretion. Hypothalamo-Hypophyseal System / surgery. Male. Middle Aged. Pituitary Hormones / blood. Pituitary Hormones / secretion. Preoperative Care / methods. Prospective Studies. Stereotaxic Techniques. Treatment Outcome

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  • (PMID = 19002375.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Pituitary Hormones
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21. Frank G, Pasquini E, Doglietto F, Mazzatenta D, Sciarretta V, Farneti G, Calbucci F: The endoscopic extended transsphenoidal approach for craniopharyngiomas. Neurosurgery; 2006 Jul;59(1 Suppl 1):ONS75-83; discussion ONS75-83
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  • [Title] The endoscopic extended transsphenoidal approach for craniopharyngiomas.
  • The authors present their experience with this technique in 10 patients with craniopharyngiomas.
  • From November 1998 through May 2005, four males and six females with a craniopharyngioma, either purely supradiaphragmatic (six patients) or with a significant suprasellar component (four patients), were treated.
  • Further studies are required to better define the exact location of the tumor with respect to the arachnoidal plane, the extra-arachnoidal craniopharyngioma being the most suitable for a radical removal using a transsphenoidal supradiaphragmatic approach.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopy / methods. Neurosurgical Procedures / instrumentation. Pituitary Neoplasms / surgery. Sella Turcica / surgery. Sphenoid Sinus / surgery
  • [MeSH-minor] Adult. Cerebrospinal Fluid Rhinorrhea / etiology. Cerebrospinal Fluid Rhinorrhea / physiopathology. Child. Diabetes Insipidus, Neurogenic / etiology. Diabetes Insipidus, Neurogenic / physiopathology. Endocrine System Diseases / etiology. Endocrine System Diseases / physiopathology. Female. Follow-Up Studies. Humans. Hypothalamo-Hypophyseal System / physiopathology. Male. Middle Aged. Obesity / etiology. Obesity / physiopathology. Optic Chiasm / anatomy & histology. Optic Chiasm / pathology. Optic Chiasm / surgery. Pituitary Diseases / etiology. Pituitary Diseases / physiopathology. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Subarachnoid Space / anatomy & histology. Subarachnoid Space / surgery. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 16888556.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Siemons W, Wilms G, Theys T: Optic tract edema sign and craniopharyngiomas. JBR-BTR; 2010 Jan-Feb;93(1):28-9
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  • [Title] Optic tract edema sign and craniopharyngiomas.
  • Two patients with craniopharyngioma presenting with the "optic tract edema sign" are described.
  • This sign is seen in a majority of craniopharyngiomas and can be of help in the differentiation with other suprasellar masses such as pituitary adenomas, meningiomas, germinomas and lymphomas.
  • [MeSH-major] Craniopharyngioma / pathology. Edema / pathology. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / pathology. Visual Pathways / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Pituitary Gland / pathology. Pituitary Gland / surgery

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  • (PMID = 20397431.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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23. de Divitiis E, Cappabianca P, Cavallo LM, Esposito F, de Divitiis O, Messina A: Extended endoscopic transsphenoidal approach for extrasellar craniopharyngiomas. Neurosurgery; 2007 Nov;61(5 Suppl 2):219-27; discussion 228
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  • [Title] Extended endoscopic transsphenoidal approach for extrasellar craniopharyngiomas.
  • OBJECTIVE: Suprasellar craniopharyngiomas have been classically removed using a variety of transcranial approaches.
  • With the advent of the endoscope in transsphenoidal surgery, its obvious advantages combined with neurosurgeons' increasing interest in extended transsphenoidal approaches made suprasellar and even intraventricular craniopharyngiomas accessible for removal via such a low route.
  • PATIENTS AND METHODS: Between January of 2004 and April of 2006, six men and four women (mean age, 57.2 yr; range, 26-70 yr) underwent surgery for craniopharyngioma, including two intrasuprasellar, one suprasellar, six suprasellar-intraventricular, and one that was purely intraventricular.
  • RESULTS: Total craniopharyngioma removal was achieved for seven patients, subtotal removal was possible for two patients, and one patient had a partial removal.
  • CONCLUSION: For selected patients, the extended endoscopic endonasal approach for removal of suprasellar craniopharyngioma seems to provide a valid alternative to transcranial approaches.
  • [MeSH-major] Craniopharyngioma / surgery. Neuroendoscopy. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery. Sphenoid Sinus / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Treatment Refusal

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  • (PMID = 18091236.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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24. Agozzino L, Ferraraccio F, Accardo M, Esposito S, Agozzino M, Cuccurullo L: Morphological and ultrastructural findings of prognostic impact in craniopharyngiomas. Ultrastruct Pathol; 2006 May-Jun;30(3):143-50
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  • [Title] Morphological and ultrastructural findings of prognostic impact in craniopharyngiomas.
  • Craniopharyngioma is a slow-growing epithelial tumor with an unpredictable tendency to recur.
  • The MIB-1 Labelling Index was: 22.12% in primary tumors, 27.5% in recurrences, 31.3% in adult nonrecurrent tumors, and 4.1% in the pediatric tumor.
  • Lack of clear correlations between morphological or immuno-staining patterns and behavior suggests that these features have no prognostic value in adult as well as in pediatric craniopharyngiomas.
  • In this study, the only results that may be related to the aggressiveness of tumor is the major vascularization in the recurrent tumors in which the vessels show also ultrastructural changes.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Child, Preschool. Cytoplasm / ultrastructure. Endothelium, Vascular / ultrastructure. Epithelial Cells / ultrastructure. Female. Humans. Ki-67 Antigen / analysis. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local. Proliferating Cell Nuclear Antigen / analysis. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 16825115.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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25. Coppens JR, Couldwell WT: Staged use of the transsphenoidal approach to resect superior third ventricular craniopharyngiomas. Minim Invasive Neurosurg; 2010 Feb;53(1):40-3
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  • [Title] Staged use of the transsphenoidal approach to resect superior third ventricular craniopharyngiomas.
  • INTRODUCTION: Craniopharyngiomas are benign tumors, usually originating from the infundibulum or tuber cinereum.
  • Large craniopharyngiomas that invade the upper third of the third ventricle are a common reason for patients to need a second operation to accomplish a gross total resection.
  • Transsphenoidal approaches are being increasingly used in the treatment of craniopharyngiomas.
  • Large craniopharyngiomas involving the superior third ventricle are most commonly resected through a staged approach, often involving a transcortical or interhemispheric route.
  • CASE REPORT: The authors describe the use of an extended transsphenoidal approach as a second-stage operation to resect the intraventricular component of a large craniopharyngioma in an illustrative case.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Neuroendoscopy / methods. Pituitary Neoplasms / surgery. Sphenoid Sinus / surgery. Third Ventricle / surgery
  • [MeSH-minor] Adult. Decompression, Surgical / methods. Humans. Male. Neoplasm, Residual / diagnosis. Neoplasm, Residual / surgery. Postoperative Complications / diagnosis. Reoperation

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20376745.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Bikmaz K, Guerrero CA, Dammers R, Krisht AF, Husain MM: Ectopic recurrence of craniopharyngiomas: case report. Neurosurgery; 2009 Feb;64(2):E382-3; discussion E383
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  • [Title] Ectopic recurrence of craniopharyngiomas: case report.
  • OBJECTIVE: Craniopharyngiomas are benign tumors that originate from squamous cell rests of the embryonal hypophyseal-pharyngeal duct located along the pituitary stalk.
  • After their surgical resection, recurrence usually occurs in the region of the original tumor bed.
  • Ectopic recurrence of craniopharyngiomas is extremely rare.
  • We present 3 examples of ectopic recurrences of craniopharyngiomas.
  • CLINICAL PRESENTATION: The first patient was a 52-year-old woman with a history of resected suprasellar craniopharyngioma presenting 15 years later with a history of balance problems and new onset of double vision.
  • Her magnetic resonance imaging scan revealed a tumor in the prepontine cistern.
  • The second patient was a 41-year-old man with a history of a resected suprasellar craniopharyngioma presenting 9 years later with headache, dizziness, and disequilibrium.
  • The third patient was a 24-year-old man with a history of suprasellar craniopharyngioma resection, followed by conventional radiotherapy 12 years before his recent presentation with headache, numbness of the right side of his face, and increased drowsiness.
  • INTERVENTION: The first patient underwent operation via a petrosal approach with subtotal resection of the tumor and decompression of the brainstem; this patient had an uneventful postoperative course.
  • The tumor in the second patient was surgically resected through a pterional craniotomy, with an uneventful postoperative course.
  • The third patient's right-sided cerebellopontine angle lesion was microsurgically resected, and the patient was given a single-dose gamma knife for the left-side and residual small right-side tumor.
  • The histological diagnosis of all 3 lesions was craniopharyngioma.
  • CONCLUSION: Although ectopic recurrence of a craniopharyngioma is very rare, it should always be considered in the differential diagnosis of what appears to be a new tumor in a patient with a history of previously resected craniopharyngiomas.
  • Long-term follow-up of patients with resected craniopharyngioma is very important.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19190442.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Zhou L, Li Q, Luo L, Xu J, Zhang Y, Chen T, Wei Y, You C: Radiological features of craniopharyngiomas located in the posterior fossa. J Neurol Sci; 2009 Dec 15;287(1-2):119-25
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  • [Title] Radiological features of craniopharyngiomas located in the posterior fossa.
  • BACKGROUND AND PURPOSE: Posterior fossa craniopharyngiomas (PFCP) constitute 1.6-4% of all craniopharyngiomas and have long been neglected.
  • Seven tumors were of retrochiasmatic origin and 5 of 7 were of retrostalk growth pattern with location in the ventral area of brain stem.
  • Total tumor removal was accomplished in 5 cases, subtotal removal and partial removal in 1 case respectively.
  • Tumor with cystic component arises from sellar region and then extends to posterior fossa, which should be strongly suspected as a PFCP.
  • [MeSH-major] Cranial Fossa, Posterior / pathology. Craniopharyngioma / pathology. Infratentorial Neoplasms / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Central Nervous System Cysts / etiology. Central Nervous System Cysts / pathology. Central Nervous System Cysts / radiography. Child. Cohort Studies. Craniotomy / methods. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Pituitary Gland / pathology. Pituitary Gland / radiography. Pituitary Gland / surgery. Sella Turcica / pathology. Sella Turcica / radiography. Sella Turcica / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19758604.001).
  • [ISSN] 1878-5883
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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28. Albright AL, Hadjipanayis CG, Lunsford LD, Kondziolka D, Pollack IF, Adelson PD: Individualized treatment of pediatric craniopharyngiomas. Childs Nerv Syst; 2005 Aug;21(8-9):649-54
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  • [Title] Individualized treatment of pediatric craniopharyngiomas.
  • OBJECTIVE: The treatment of children with craniopharyngiomas should be individualized because of their heterogeneous clinical and radiographic characteristics.
  • METHODS: Medical records were reviewed for children with craniopharyngiomas who presented to the Children's Hospital of Pittsburgh for their initial management between 1983 and 2004.
  • Children were treated with microsurgical tumor resections (27), intracavitary irradiation with phosphorus 32 (32P) (12), and with gamma knife stereotactic radiosurgery (GKSR) (5).
  • There was no morbidity or mortality from GKSR, which achieved tumor stabilization or shrinkage in 4 of 5 cases.
  • Resections, 32P, and GKSR are complimentary treatment modalities for children with craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy / methods. Female. Follow-Up Studies. Humans. Infant. Male. Medical Records / statistics & numerical data. Microsurgery / methods. Radiography. Radiosurgery / methods. Retrospective Studies. Stereotaxic Techniques. Treatment Outcome

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  • [Cites] Neurosurgery. 1997 Feb;40(2):263-9; discussion 269-70 [9007857.001]
  • [Cites] Childs Nerv Syst. 1999 Nov;15(11-12):764-9 [10603020.001]
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  • (PMID = 15931512.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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29. Liu JK, Christiano LD, Gupta G, Carmel PW: Surgical nuances for removal of retrochiasmatic craniopharyngiomas via the transbasal subfrontal translamina terminalis approach. Neurosurg Focus; 2010 Apr;28(4):E6
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  • [Title] Surgical nuances for removal of retrochiasmatic craniopharyngiomas via the transbasal subfrontal translamina terminalis approach.
  • Giant craniopharyngiomas in the retrochiasmatic space are challenging tumors, given the location and surrounding vital structures.
  • This provides the significant advantage of visualization of both walls of the third ventricle and hypothalamus as well as inferior midline access to the interpeduncular cistern to permit safe neurovascular dissection and total tumor removal.
  • In this report, the authors describe the transbasal subfrontal translamina terminalis approach, with specific emphasis on technical surgical nuances in removing retrochiasmatic craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Hypophysectomy / methods. Optic Chiasm / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Craniotomy / methods. Decompression, Surgical / methods. Dissection / methods. Female. Humans. Videotape Recording

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  • (PMID = 20367363.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Cavallo LM, Prevedello DM, Solari D, Gardner PA, Esposito F, Snyderman CH, Carrau RL, Kassam AB, Cappabianca P: Extended endoscopic endonasal transsphenoidal approach for residual or recurrent craniopharyngiomas. J Neurosurg; 2009 Sep;111(3):578-89
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  • [Title] Extended endoscopic endonasal transsphenoidal approach for residual or recurrent craniopharyngiomas.
  • OBJECT: The management of recurrent or residual craniopharyngiomas remains controversial.
  • The extended (also called expanded) endoscopic endonasal transsphenoidal approach through the planum sphenoidale has been proposed over the past decade as an alternative surgical route for removal of various suprasellar tumors including craniopharyngiomas.
  • In this study, the authors describe the feasibility and advantages of this technique in recurrent or symptomatic residual craniopharyngiomas.
  • METHODS: Between January 2004 and June 2008, 22 patients underwent surgery via the extended endoscopic transsphenoidal approach for the treatment of recurrent or residual symptomatic craniopharyngiomas at either the University of Pittsburgh or the Universita degli Studi di Napoli.
  • The lesions included 12 purely suprasellar craniopharyngiomas, 9 with both intra- and suprasellar extensions, and 1 arising from a remnant in the Meckel cave.
  • To better evaluate the features of the extended endonasal approach for recurrent or residual craniopharyngiomas, each patient was assigned to 1 of 3 subgroups depending on the original surgical treatment: transcranial pterional route (13 patients), transphenoidal approach (3 patients; 2 microsurgically and 1 with the standard endoscopic technique), or extended endonasal endoscopic approach (6 patients).
  • Subtotal removal (>70%) was attained in 4 patients (18.2%), and tumor removal was partial (<50%) in only 1 case (4.5%).
  • CONCLUSIONS: Most of the advantages of the endoscopic endonasal technique were noted during tumor dissection from the inferior aspect of the chiasm, the infundibulum, the third ventricle, and/or the retro- and parasellar areas.
  • The endoscopic endonasal technique should be considered as a therapeutic option in selected cases of recurrent or symptomatic residual craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Neuroendoscopy / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Neurosurgical Procedures / methods. Postoperative Complications. Reoperation. Treatment Outcome

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  • (PMID = 19326977.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Shi XE, Wu B, Zhou ZQ, Fan T, Zhang YL: Microsurgical treatment of craniopharyngiomas: report of 284 patients. Chin Med J (Engl); 2006 Oct 5;119(19):1653-63
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  • [Title] Microsurgical treatment of craniopharyngiomas: report of 284 patients.
  • BACKGROUND: Generally, total surgical removal of craniopharyngioma results in satisfactory outcome with a low recurrence rate, however, the location of the tumor and its adherence to the hypothalamic structures can make the operation difficult.
  • The goal of the present study was to assess the outcome of craniopharyngiomas in 284 patients treated surgically.
  • METHODS: A total of 284 patients (151 men and 133 women) with craniopharyngioma were treated surgically by our neurosurgeons from January 1996 to March 2006.
  • The tumors were classified into the superior (23 patients) and inferior ventricular (261) types according to the location of the tumor relative to the third ventricular floor.
  • For the patients with craniopharyngioma of inferior ventricular type, pterional approach was used in 191 (67.3%) patients, subfrontal approach in 17 (6.0%), and translamina terminalis through frontobasal interhemispheric approach in 53 (18.7%).
  • Of the 284 patients, 204 (71.8%) were followed up for 0.5 to 8 years (mean, 2.1 +/- 1.8), including 162 patients received total tumor removal, and 37 underwent subtotal or partial removal.
  • During the follow-up, 23 (14.1%) patients experienced tumor recurrence 1.0 - 3.5 years (mean, 1.8 +/- 1.6) after total tumor removal, and 24 (64.9%) had recurrent tumor 0.25 - 1.5 years (mean, 0.5 +/- 0.4) after subtotal or partial resection.
  • In addition, preservation of the pituitary stalk is critical when total tumor resection is feasible.
  • [MeSH-major] Craniopharyngioma / surgery. Microsurgery / methods. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged

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  • (PMID = 17042979.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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32. Sun HI, Akgun E, Bicer A, Ozkan A, Bozkurt SU, Kurtkaya O, Koc DY, Pamir MN, Kilic T: Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence. Neurosurgery; 2010 Apr;66(4):744-50; discussion 750
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  • [Title] Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence.
  • BACKGROUND: The primary treatment for craniopharyngiomas is total excision, but recurrence is common.
  • OBJECTIVE: We hypothesized that recurrence is linked to the angiogenesis of the tumor.
  • Recurrent and nonrecurrent tumor samples were compared with regard to expression of angiogenesis-related factors and angiogenic capacity in a corneal angiogenesis model.
  • METHODS: Specimens of 4 recurrent and 6 nonrecurrent tumors were selected from 57 patients with adamantinomatous craniopharyngiomas.
  • Expression levels were graded using a 4-point scoring system and were compared.
  • CONCLUSION: These findings suggest a relationship between recurrence of craniopharyngiomas and angiogenesis.
  • New treatment modalities with selective PDGFR-alpha blockers may represent a novel and effective therapeutic option for the treatment of craniopharyngiomas.
  • [MeSH-major] Angiogenesis Inducing Agents / metabolism. Craniopharyngioma / metabolism. Gene Expression Regulation, Neoplastic / physiology. Neoplasm Recurrence, Local / metabolism. Pituitary Neoplasms / metabolism
  • [MeSH-minor] Adult. Animals. Cornea / metabolism. Cornea / pathology. Disease Models, Animal. Female. Fibroblast Growth Factor 2 / metabolism. Fibronectins / metabolism. Humans. Male. Middle Aged. Neoplasm Transplantation. Platelet-Derived Growth Factor / metabolism. Rats. Rats, Sprague-Dawley. Retrospective Studies. Statistics, Nonparametric. Time Factors. Vascular Endothelial Growth Factor A / metabolism. Young Adult

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  • (PMID = 20190664.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Fibronectins; 0 / Platelet-Derived Growth Factor; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
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33. Fatemi N, Dusick JR, de Paiva Neto MA, Malkasian D, Kelly DF: Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas. Neurosurgery; 2009 May;64(5 Suppl 2):269-84; discussion 284-6
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  • [Title] Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas.
  • OBJECTIVE: Endonasal and supraorbital "eyebrow" craniotomies are increasingly being used to remove craniopharyngiomas and tuberculum sellae meningiomas.
  • METHODS: All consecutive patients who had endonasal or supraorbital removal of a craniopharyngioma or tuberculum sellae meningioma were analyzed.
  • RESULTS: Of 43 patients, 22 had a craniopharyngioma (18 endonasal, 4 supraorbital), and 21 had a meningioma (12 endonasal, 7 supraorbital, 2 both routes); 33% had prior surgery.
  • Craniopharyngiomas were primarily retrochiasmal in location in 78% of endonasal cases versus 25% of supraorbital cases (P = 0.08).
  • Of patients having first-time surgery for a craniopharyngioma (n = 14) or meningioma (n = 15), total/near total removal was achieved in 83% and 80% of patients by the endonasal route and in 50% and 80% of patients by the supraorbital route, respectively.
  • CONCLUSION: The endonasal route is preferred for removal of most retrochiasmal craniopharyngiomas, whereas the supraorbital route is recommended for meningiomas larger than 30 to 35 mm or with growth beyond the supraclinoid carotid arteries.
  • For smaller midline tumors, either approach can be used, depending on surgeon experience and tumor anatomy.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Meningeal Neoplasms / surgery. Meningioma / surgery. Pituitary Neoplasms / surgery. Sella Turcica / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Endoscopy / methods. Female. Frontal Bone / anatomy & histology. Frontal Bone / surgery. Humans. Intraoperative Complications / prevention & control. Male. Middle Aged. Nasal Cavity / anatomy & histology. Nasal Cavity / surgery. Neurosurgical Procedures / instrumentation. Neurosurgical Procedures / methods. Orbit / anatomy & histology. Orbit / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19287324.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Buslei R, Hölsken A, Hofmann B, Kreutzer J, Siebzehnrubl F, Hans V, Oppel F, Buchfelder M, Fahlbusch R, Blümcke I: Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas. Acta Neuropathol; 2007 May;113(5):585-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas.
  • Activation of the Wnt/wingless signalling cascade is a key mechanism in developmental morphogenesis, whereas aberrant nuclear accumulation of beta-catenin in adult tissues seems to be associated with neoplastic transformation and tumour progression.
  • Adamantinomatous craniopharyngiomas carry activating mutations in exon 3 of the beta-catenin gene, which results in a distinct pattern of nuclear beta-catenin accumulation in up to 95% of respective tumour specimens.
  • To better characterise the impact of nuclear beta-catenin aggregation in these neoplasms, we systematically examined epithelial differentiation and cell cycle-associated molecules in accumulating compared to non-accumulating tumour cell clusters using a cohort of 65 adamantinomatous craniopharyngiomas.
  • Our data support an impact of nuclear beta-catenin on different cytoarchitectural and epithelial differentiation patterns in adamantinomatous craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / metabolism. Craniopharyngioma / pathology. Epithelium / growth & development. Morphogenesis / physiology. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Differentiation. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Female. Gene Expression Regulation, Neoplastic / physiology. Humans. Keratin-18 / metabolism. Keratin-8 / metabolism. Male. Middle Aged

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  • (PMID = 17221204.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Keratin-18; 0 / Keratin-8; 0 / beta Catenin
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35. Gupta DK, Ojha BK, Sarkar C, Mahapatra AK, Mehta VS: Recurrence in craniopharyngiomas: analysis of clinical and histological features. J Clin Neurosci; 2006 May;13(4):438-42
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  • [Title] Recurrence in craniopharyngiomas: analysis of clinical and histological features.
  • The aim of this study was to investigate the recurrence patterns and significance of various clinical and histological features as predictors of recurrence in craniopharyngiomas.
  • A series of 234 craniopharyngiomas (156 males, 78 females; age range 1.6-65 years) was reviewed.
  • Peri-operative mortality was 7.4% and tumor recurrence was observed in 26 patients (20.3%).
  • Of the patients with recurrence, one had total tumor excision (recurrence-free survival (RFS) 14 months), four had near-total excision (mean RFS 18.2 months) and 21 had subtotal tumor excision (RFS for symptomatic recurrence 7.1 months).
  • Brain tissue was included in 67 cases and brain invasion was noted in 44 (all were of adamantinous histology).
  • No correlation was noted between histopathological subtyping or brain invasion and recurrence.
  • The significant clinical factors predictive of recurrence included the extent of resection, tumor size greater than 4 cm and cystic tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Craniopharyngioma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16678722.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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36. Minamida Y, Mikami T, Hashi K, Houkin K: Surgical management of the recurrence and regrowth of craniopharyngiomas. J Neurosurg; 2005 Aug;103(2):224-32
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  • [Title] Surgical management of the recurrence and regrowth of craniopharyngiomas.
  • OBJECT: The authors performed a retrospective analysis of a consecutive series of craniopharyngiomas and their recurrences, which were managed with surgery alone.
  • METHODS: In the past 20 years, 37 consecutive patients with craniopharyngiomas underwent surgery without adjuvant radiotherapy.
  • Of these 37 patients, 11 experienced tumor recurrence (29.7%) during the mean follow-up period of 11.1 years.
  • Using a proper surgical approach (mainly a basal interhemispheric approach) and meticulous microsurgical techniques, total removal of the recurrent tumor was achieved in nine surgeries (52.9).
  • CONCLUSIONS: Recurrence of craniopharyngioma can be safely managed by using meticulous contemporary microsurgical techniques without additional radiotherapy.
  • The role of surgery and adjuvant radiotherapy for craniopharyngiomas may vary in the future, depending on innovations in treatment and technology.
  • Nevertheless, surgery can be still a major therapeutic option in the management of recurrent craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cognition. Disease Progression. Humans. Infant. Male. Middle Aged. Morbidity. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis

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  • (PMID = 16175850.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Cao J, Lin JP, Yang LX, Chen K, Huang ZS: Expression of aberrant beta-catenin and impaired p63 in craniopharyngiomas. Br J Neurosurg; 2010 Jun;24(3):249-56
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  • [Title] Expression of aberrant beta-catenin and impaired p63 in craniopharyngiomas.
  • Craniopharyngiomas are rare, histologically benign, non-neuroepithelial epithelial tumors arising from the sellar region, the molecular pathogenesis of CPs is yet not understood.
  • The aim of the present study was to assess expression of aberrant beta-catenin and impaired p63 in 66 craniopharyngiomas included 51 adamantinomatous craniopharyngiomas and 15 squamous papillary craniopharyngiomas.
  • On immunohistochemistry, 47 out of 51 adamantinomatous craniopharyngiomas, but not squamous papillary craniopharyngiomas, showed strong nuclear/cytoplasmic expression for beta-catenin predominantly in compactly cohesive epithelial cells within the whorl-like arrays where ki-67 was almost absent and rarely in palisaded cells where ki-67 was mainly present.
  • P63 overexpression was observed in 45 out of 51 adamantinomatous craniopharyngiomas and 14 out of 15 squamous papillary craniopharyngiomas.
  • P63 stained not only in the nuclei of basal layer cells but also within the whorl-like arrays in adamantinomatous craniopharyngiomas and uniformly in squamous papillary craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / metabolism. Membrane Proteins / metabolism. Pituitary Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA-Binding Proteins / metabolism. Female. Humans. Immunohistochemistry. Infant. Ki-67 Antigen / metabolism. Male. Middle Aged. RNA, Messenger / metabolism. Trans-Activators / metabolism. Transcription Factors. Tumor Suppressor Proteins / metabolism. Young Adult

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  • (PMID = 20128632.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / beta Catenin
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38. Karavitaki N, Brufani C, Warner JT, Adams CB, Richards P, Ansorge O, Shine B, Turner HE, Wass JA: Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol (Oxf); 2005 Apr;62(4):397-409
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  • [Title] Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up.
  • BACKGROUND: Craniopharyngiomas account for 2-5% of all primary intracranial tumours.
  • AIM: To analyse the natural history and treatment outcome of children and adults presenting to the Departments of Paediatrics and Endocrinology with craniopharyngioma between 1964 and 2003.
  • In this large series no substantial differences in the outcome of tumours diagnosed during childhood or adult life were found.
  • CONCLUSIONS: Craniopharyngiomas remain tumours associated with significant morbidity.
  • Childhood- and adult-onset lesions generally behave similarly.
  • [MeSH-major] Craniopharyngioma. Neoplasm Recurrence, Local. Pituitary Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Statistics, Nonparametric. Survival Rate

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  • (PMID = 15807869.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 65
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39. Pekmezci M, Louie J, Gupta N, Bloomer MM, Tihan T: Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005. Neurosurgery; 2010 Nov;67(5):1341-9; discussion 1349
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  • [Title] Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005.
  • BACKGROUND: Craniopharyngiomas are rare epithelial tumors that are presumed to arise from the remnants of Rathke's pouch.
  • OBJECTIVE: This study was designed to evaluate the outcome characteristics of craniopharyngiomas treated in a single institution and to determine whether the adamantinomatous craniopharyngioma should be considered more aggressive than a World Health Organization (WHO) grade I neoplasm.
  • METHODS: We identified all patients with craniopharyngioma given their diagnoses at University of California, San Francisco in a 20-year period and performed a retrospective analysis of clinicopathological and outcome characteristics.
  • CONCLUSION: Adamantinomatous craniopharyngioma is a locally aggressive neoplasm with a significant rate of recurrence.
  • This is not in keeping with the current designation of a WHO grade I neoplasm.
  • Given the high numbers of "silent" defects, formal visual field testing should be performed in all patients with craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / mortality. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / mortality. Pituitary Neoplasms / mortality. Pituitary Neoplasms / surgery. Postoperative Complications / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. California / epidemiology. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Longitudinal Studies. Male. Middle Aged. Prevalence. Risk Assessment. Risk Factors. Survival Analysis. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20871436.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Campbell PG, McGettigan B, Luginbuhl A, Yadla S, Rosen M, Evans JJ: Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas. Neurosurg Focus; 2010 Apr;28(4):E8
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  • [Title] Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas.
  • OBJECT: The expanded endoscopic approach to craniopharyngiomas has recently been described in several small case series.
  • METHODS: Between September 2006 and September 2009, 14 patients underwent a purely endoscopic, endonasal approach for resection of newly diagnosed craniopharyngiomas.
  • These procedures represent index surgeries; no patient had undergone previous tumor resection.
  • Additionally, a review of the English literature was performed to evaluate outcomes of similar endoscopic techniques for resection of craniopharyngiomas.
  • CONCLUSIONS: The endoscopic endonasal approach is a minimally invasive alternative to open transcranial approaches for select craniopharyngiomas.
  • Similar to previous transcranial series, rates of endocrinopathy and gross-total resection were dependent upon the adherence of the tumor capsule to the hypothalamus, pituitary stalk, and associated vasculature.
  • [MeSH-major] Craniopharyngioma / surgery. Neuroendoscopy / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebrospinal Fluid Rhinorrhea / etiology. Diabetes Insipidus / etiology. Female. Hemianopsia / etiology. Humans. Male. Middle Aged. Nasal Cavity. Neurosurgical Procedures / methods. Postoperative Complications / etiology. Treatment Outcome. Vision Disorders / etiology. Visual Fields / physiology

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  • [CommentIn] Neurosurg Focus. 2010 Apr;28(4):E8a; discussion E8b [20367366.001]
  • (PMID = 20367365.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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41. Schmalisch K, Beschorner R, Psaras T, Honegger J: Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature. Acta Neurochir (Wien); 2010 Feb;152(2):313-9; discussion 319
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  • [Title] Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature.
  • PURPOSE: Seeding of craniopharyngioma has been rarely reported.
  • METHODS: The first patient was a 13-year-old boy who had initially undergone radical excision of a suprasellar and retrosellar craniopharyngioma by a right pterional approach.
  • Postoperative MRI showed no evidence of residual tumor.
  • Two years later, MRI revealed a local recurrence and in addition a separated cystic tumor on the right side adjacent to the middle cerebral artery consistent with seeding along the surgical route.
  • On histopathological examination, both, the local recurrent tumor and the distant deposit turned out to be adamantinomatous craniopharyngiomas.
  • The second patient was a 27-year-old woman who was operated on for the first time via a right pterional and 1 year later for a recurrent craniopharyngioma via a transsphenoidal approach.
  • This deposit in the operative pathway was found to be an adamantinomatous craniopharyngioma, as was the initial tumor.
  • The recent control MRT revealed a right parietal intracranial tumor with peripheral contrast enhancement, which was located distant to the former craniotomy.
  • The tumor was removed and histopathological examination revealed an adamantinomatous craniopharyngioma in accordance with the initial tumor.
  • CONCLUSION: Although craniopharyngiomas exhibit a benign histopathological pattern, cerebrospinal fluid seeding along the surgical route or along the CSF pathways has been observed.
  • Ectopic recurrence of craniopharyngioma suggests that meticulous protection of the whole surgical field and careful handling of the tumor during the operation are required.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Metastasis / pathology. Neoplasm Seeding. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Craniotomy. Female. Frontal Bone / pathology. Frontal Bone / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Parietal Bone / pathology. Parietal Bone / surgery. Reoperation. Treatment Outcome

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  • (PMID = 19859655.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 31
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42. Baldelli R, Bianchi A, Diacono F, Passeri M, Fusco A, Valle D, Poggi M, Terlini M, Toscano V, Tamburrano G, Pontecorvi A, Maira G, De Marinis L: Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas. J Endocrinol Invest; 2005 Feb;28(2):157-61
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  • [Title] Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas.
  • The aim of the present study was to evaluate the characteristics of GH deficiency (GHD) in adult patients after neurosurgery for pituitary adenomas and craniopharingiomas.
  • One hundred and one GHD patients, (42 F/59 M), aged 47.58+/-14.4 yr (mean+/-SD; range 21-78), body mass index (BMI) 28.6+/-0.6, with a history of adult-onset hypothalamic-pituitary disease, were recruited for the study.
  • The whole group included: 45 non-functioning pituitary adenomas, 23 craniopharyngiomas, 16 PRLomas, 8 GHomas, 7 ACTHomas and 2 FSHomas; in particular 51 were macroadenomas and 27 microadenomas.
  • [MeSH-major] Adenoma / surgery. Craniopharyngioma / surgery. Human Growth Hormone / deficiency. Neurosurgical Procedures. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Arginine. Cushing Syndrome / blood. Cushing Syndrome / metabolism. Cushing Syndrome / surgery. Drug Combinations. Female. Growth Hormone-Releasing Hormone. Humans. Insulin-Like Growth Factor I / metabolism. Male. Middle Aged. Postoperative Period

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  • (PMID = 15887862.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Drug Combinations; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; 9034-39-3 / Growth Hormone-Releasing Hormone; 94ZLA3W45F / Arginine
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43. Izumoto S, Suzuki T, Kinoshita M, Hashiba T, Kagawa N, Wada K, Fujimoto Y, Hashimoto N, Saitoh Y, Maruno M, Yoshimine T: Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: correlation with clinical and histologic features. Surg Neurol; 2005 Jun;63(6):520-5; discussion 525
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  • [Title] Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: correlation with clinical and histologic features.
  • BACKGROUND: Although craniopharyngiomas have a histologically benign nature, their treatment can be difficult.
  • The correlation among clinical, proliferative, and immunohistologic features of female sex hormone receptors was determined in craniopharyngiomas to analyze whether they influence the growth of the tumor.
  • METHODS: The study subjects were 43 patients with previously untreated craniopharyngioma who underwent surgery at our department over the past 15 years.
  • ER and PR were detected in 9 of 30 (30%) craniopharyngiomas, and the incidence of postoperative tumor regrowth was significantly higher in patients negative for ER and PR (29%) than in those positive for both receptors (11%).
  • CONCLUSIONS: A high Ki-67 labeling index suggests a high possibility of tumor regrowth, and the presence of ER and PR is suggestive of a high tissue differentiating potential.
  • ER and PR assay may be useful for determining the indication for additional radiation therapy in craniopharyngioma patients treated by incomplete resection.
  • [MeSH-major] Biomarkers, Tumor / analysis. Craniopharyngioma / diagnosis. Ki-67 Antigen / analysis. Pituitary Neoplasms / diagnosis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures. Patient Selection. Predictive Value of Tests. Prognosis. Radiotherapy / standards

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  • (PMID = 15936368.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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44. Julow J, Backlund EO, Lányi F, Hajda M, Bálint K, Nyáry I, Szeifert GT: Long-term results and late complications after intracavitary yttrium-90 colloid irradiation of recurrent cystic craniopharyngiomas. Neurosurgery; 2007 Aug;61(2):288-95; discussion 295-6
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  • [Title] Long-term results and late complications after intracavitary yttrium-90 colloid irradiation of recurrent cystic craniopharyngiomas.
  • OBJECTIVE: Data were analyzed to assess the value of stereotactically applied intracystic colloidal yttrium-90 (YTx) for the treatment of recurrent cystic craniopharyngiomas during a 30-year period.
  • CONCLUSION: Despite sporadic complications, intracavitary YTx irradiation is a valuable treatment alternative for craniopharyngioma cysts, sometimes as part of a multimodality management in these tumors, especially in precarious surgical cases.
  • [MeSH-major] Brachytherapy / methods. Craniopharyngioma / radiotherapy. Cysts / radiotherapy. Pituitary Neoplasms / radiotherapy. Yttrium Radioisotopes / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Colloids. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Radiosurgery. Radiotherapy Dosage. Recurrence. Tomography, X-Ray Computed

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  • (PMID = 17762741.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Colloids; 0 / Yttrium Radioisotopes
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45. Hofmann BM, Hoelsken A, Fahlbusch R, Blümcke I, Buslei R: Hormone receptor expression in craniopharyngiomas: a clinicopathological correlation. Neurosurgery; 2010 Sep;67(3):617-25; discussion 625
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  • [Title] Hormone receptor expression in craniopharyngiomas: a clinicopathological correlation.
  • BACKGROUND: Extensive neurosurgical resection of craniopharyngiomas often requires lifetime hormonal substitution.
  • OBJECTIVE: We investigated the effect of the hormone receptor expression of insulinlike growth factor-1, growth hormone-releasing hormone receptor, growth hormone, progesterone, estrogen (ER-1, ER-beta), and leptins (Ra6.4, Ra12.1, Rb) on tumor recurrence, size, and proliferation using clinical, histopathological, and molecular genetic analysis.
  • PATIENTS AND METHODS: cDNA expression analysis was obtained in a cohort of 20 patients suffering from a craniopharyngioma to systematically determine the expression of above-mentioned receptors.
  • In addition, 51 tumor samples were available to immunohistochemically investigate the extent and distribution of estrogen and progesterone receptors.
  • In 18 tumor specimens, both experimental paradigms could be performed.
  • RESULTS: All hormone receptors under study, including leptins, were detectable in craniopharyngiomas with reverse-transcription polymerase chain reaction but did not reach significance regarding the tested parameters.
  • However, a correlation was observed between tumor size and cell proliferation indexes, as well as with cDNA expression levels of ER-1 and growth hormone receptors.
  • CONCLUSION: The present preliminary data point to a correlation between estrogen and growth hormone receptor expression and proliferation indexes with tumor size in craniopharyngiomas.
  • This is the first report about leptin expression in this tumor entity.
  • These findings should prompt careful consideration of hormonal replacement therapy regimens in patients with tumor remnants and evidence of respective receptor expression.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Craniopharyngioma / metabolism. Hormones / metabolism. Pituitary Neoplasms / metabolism. Receptors, Cytoplasmic and Nuclear / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cohort Studies. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 20647974.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Hormones; 0 / Receptors, Cytoplasmic and Nuclear
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46. Kawamata T, Amano K, Aihara Y, Kubo O, Hori T: Optimal treatment strategy for craniopharyngiomas based on long-term functional outcomes of recent and past treatment modalities. Neurosurg Rev; 2010 Jan;33(1):71-81
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  • [Title] Optimal treatment strategy for craniopharyngiomas based on long-term functional outcomes of recent and past treatment modalities.
  • Although many authors have described treatment strategies for craniopharyngiomas, the optimal treatment of craniopharyngiomas remains controversial.
  • This study aimed to define an adequate surgical strategy for craniopharyngiomas by reviewing the long-term functional performance of patients treated by current and past treatment modalities.
  • There were 28 adult patients (14 males; median age, 44.4 years) and 27 children younger than 16 years of age (15 males; median age, 8.1 years).
  • Adequate primary treatment for craniopharyngiomas is important to avoid subsequent multiple treatments.
  • Craniopharyngiomas should be removed surgically as far as possible but without further deteriorating cognitive and visual functions, either as total resection or subtotal resection with a small remnant that is controllable by radiation therapy.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cognition Disorders / psychology. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Neurosurgical Procedures. Pituitary Function Tests. Postoperative Complications / pathology. Postoperative Complications / psychology. Prognosis. Radiosurgery. Tomography, X-Ray Computed. Treatment Outcome. Vision Tests. Young Adult

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  • (PMID = 19669813.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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47. Di Rocco C, Caldarelli M, Tamburrini G, Massimi L: Surgical management of craniopharyngiomas--experience with a pediatric series. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:355-66
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  • [Title] Surgical management of craniopharyngiomas--experience with a pediatric series.
  • Because of their peculiar location and the possible related postoperative sequelae, craniopharyngiomas usually present difficult management, especially in children.
  • The goal of surgery was total tumor removal.
  • Total surgical removal of craniopharyngiomas should be attempted in children whenever possible in order to minimize the risk of recurrence.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / epidemiology. Radiosurgery. Retrospective Studies. Survival Analysis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16700311.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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48. Dusick JR, Fatemi N, Mattozo C, McArthur D, Cohan P, Wang C, Swerdloff RS, Kelly DF: Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas. Surg Neurol; 2008 Nov;70(5):482-90; discussion 490-1
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  • [Title] Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas.
  • Herein we present the rates and risk factors of new hormonal failure and recovery in patients undergoing surgery for either an RCC, craniopharyngioma, or tuberculum sella meningioma.
  • METHODS: All consecutive patients treated over an 8-year period by endonasal surgery for an RCC, craniopharyngioma, or tuberculum sella meningioma were analyzed.
  • Patient characteristics, tumor size, intraoperative and postoperative events, and extent of tumor resection were correlated with new or resolved hypopituitarism.
  • RESULTS: In total, 50 patients with an RCC, 18 with a craniopharyngioma and 13 with tuberculum sellae meningioma, were analyzed.
  • New anterior pituitary failure and permanent DI occurred as follows: in RCCs, 6% and 2%; in craniopharyngiomas, 31% and 39%; and in meningiomas, 9% and 0%.
  • Overall, improved hormonal function occurred in 57% of patients with an RCC including recovery of one or more anterior axes in 9 (41%) of 22 patients and resolution of hyperprolactinemia in 12 (67%) of 18 patients; no patients with a craniopharyngioma or meningioma had resolution of hypopituitarism.
  • CONCLUSIONS: New hypopituitarism after transsphenoidal surgery occurs in approximately one third of patients with a craniopharyngioma and in less than 10% of patients with an RCC or suprasellar meningioma.
  • Hormonal function improves in the majority of patients undergoing drainage of an RCC but is unlikely to occur after removal of a craniopharyngioma or suprasellar meningioma.
  • [MeSH-major] Central Nervous System Cysts / surgery. Craniopharyngioma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Pituitary Gland / physiopathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cohort Studies. Female. Humans. Male. Middle Aged. Pituitary Function Tests. Pituitary Hormones, Anterior / metabolism. Pituitary Hormones, Posterior / metabolism. Retrospective Studies. Treatment Outcome

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  • [CommentIn] Surg Neurol. 2009 Dec;72(6):643-4; author reply 644-7 [20082835.001]
  • (PMID = 18482750.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pituitary Hormones, Anterior; 0 / Pituitary Hormones, Posterior
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49. Derrey S, Blond S, Reyns N, Touzet G, Carpentier P, Gauthier H, Dhellemmes P: Management of cystic craniopharyngiomas with stereotactic endocavitary irradiation using colloidal 186Re: a retrospective study of 48 consecutive patients. Neurosurgery; 2008 Dec;63(6):1045-52; discussion 1052-3
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  • [Title] Management of cystic craniopharyngiomas with stereotactic endocavitary irradiation using colloidal 186Re: a retrospective study of 48 consecutive patients.
  • OBJECTIVE: We retrospectively reviewed the results of stereotactic endocavitary irradiation with colloidal 186Re in the treatment of cystic craniopharyngiomas.
  • Concerning visual functions, 12 (44.5%) patients improved and 2 worsened, despite tumor control.
  • CONCLUSION: 186Re stereotactic endocavitary irradiation for the treatment of cystic craniopharyngiomas is a safe and effective procedure with a tumor control rate greater than 70%.
  • This treatment can be used for first-intention treatment of pure cystic craniopharyngiomas or for second-intention treatment of cystic recurrences.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Cysts / radiotherapy. Pituitary Neoplasms / radiotherapy. Radioisotopes / therapeutic use. Rhenium / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Colloids / therapeutic use. Female. Humans. Male. Middle Aged. Radiopharmaceuticals / therapeutic use. Radiosurgery / methods. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19057317.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Colloids; 0 / Radioisotopes; 0 / Radiopharmaceuticals; 7440-15-5 / Rhenium
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50. Gopalan R, Dassoulas K, Rainey J, Sherman JH, Sheehan JP: Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomas. Neurosurg Focus; 2008;24(5):E5
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  • [Title] Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomas.
  • The management of craniopharyngioma involves balancing adequate reduction in tumor volume and prevention of recurrence while minimizing damage to delicate surrounding structures.
  • Gamma Knife surgery (GKS) is now being considered as a viable method of providing tumor control while ensuring minimal side effects.
  • The authors conducted a literature review of 10 studies in which GKS was used to treat craniopharyngioma; some lesions had been previously treated and some had not.
  • Tumor control was achieved in 75% of cases overall and varied with tumor subtype (cystic, solid, mixed).
  • These results suggest that GKS may provide a favorable benefit-to-risk profile for many patients with craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Hypophysectomy / methods. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Brachytherapy / methods. Combined Modality Therapy. Cranial Irradiation / methods. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local / surgery. Postoperative Complications / etiology. Radiotherapy, Adjuvant. Remission Induction. Retrospective Studies. Salvage Therapy. Treatment Outcome

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  • (PMID = 18447744.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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51. Lee M, Kalani MY, Cheshier S, Gibbs IC, Adler JR, Chang SD: Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas. Neurosurg Focus; 2008;24(5):E4
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  • [Title] Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas.
  • OBJECT: Many benign intracranial tumors are amenable to radiotherapy treatment including meningiomas, schwannomas, pituitary tumors, and craniopharyngiomas.
  • The authors present their experience in the treatment of craniopharyngiomas in 16 patients using frameless CyberKnife stereotactic radiosurgery (SRS).
  • METHODS: Sixteen patients were treated for residual or recurrent craniopharyngioma between 2000 and 2007 with CyberKnife SRS at Stanford University Medical Center.
  • Tumor shrinkage was achieved in 7 of these 11 patients, and tumor control in another 3.
  • One patient had cystic enlargement of the residual tumor.
  • CONCLUSIONS: The authors' early experience with the application of CyberKnife SRS to residual or recurrent craniopharyngiomas has been positive; control or shrinkage of the tumor was achieved in 91% of patients, with no visual or neuroendocrine complications.
  • [MeSH-major] Cranial Irradiation. Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Hypophysectomy / methods. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Optic Nerve Diseases / etiology. Remission Induction. Retrospective Studies. Salvage Therapy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18447743.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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52. Gardner PA, Kassam AB, Snyderman CH, Carrau RL, Mintz AH, Grahovac S, Stefko S: Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series. J Neurosurg; 2008 Jul;109(1):6-16
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  • [Title] Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series.
  • OBJECT: Craniopharyngiomas are challenging tumors that most frequently occur in the sellar or suprasellar regions.
  • METHODS: The authors performed a retrospective review of all patients who underwent a purely endoscopic, expanded endonasal approach (EEA) for the resection of craniopharyngiomas at their institution between June 1999 and February 2006.
  • RESULTS: Sixteen patients underwent endoscopic EEA for the resection of craniopharyngiomas.
  • Three elderly patients with vision loss underwent planned debulking, 1 patient with vision loss and a moderate-sized tumor had express wishes for debulking, and 1 patient had a separate, third ventricular nodule that was not resected.
  • CONCLUSIONS: Endoscopic EEA for the resection of craniopharyngiomas provides acceptable results and holds the potential to improve outcomes.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Endoscopy. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Male. Middle Aged. Nasal Cavity. Neoplasm Invasiveness. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2008 Jul;109(1):1; reply 3-5 [18590425.001]
  • [CommentIn] J Neurosurg. 2008 Jul;109(1):1-3; reply 3-5 [18590426.001]
  • (PMID = 18590427.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Ierardi DF, Fernandes MJ, Silva IR, Thomazini-Gouveia J, Silva NS, Dastoli P, Toledo SR, Cavalheiro S: Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas. Childs Nerv Syst; 2007 Sep;23(9):1041-6
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  • [Title] Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas.
  • OBJECTIVES: The aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway.
  • MATERIALS AND METHODS: Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha.
  • The tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.
  • The concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.
  • CONCLUSIONS: Our data demonstrated that the IFN-alpha was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy.
  • [MeSH-major] Apoptosis / drug effects. Craniopharyngioma / therapy. Drug Therapy / methods. Immunologic Factors / therapeutic use. Interferon-alpha / therapeutic use. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Enzyme-Linked Immunosorbent Assay / methods. Fas Ligand Protein / metabolism. Female. Humans. Infant. Magnetic Resonance Imaging / methods. Male. Retrospective Studies. Tomography Scanners, X-Ray Computed

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  • [Cites] Childs Nerv Syst. 2005 Aug;21(8-9):719-24 [16133276.001]
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  • (PMID = 17593372.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fas Ligand Protein; 0 / Immunologic Factors; 0 / Interferon-alpha
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54. Tena-Suck ML, Salinas-Lara C, Arce-Arellano RI, Rembao-Bojórquez D, Morales-Espinosa D, Sotelo J, Arrieta O: Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas. Clin Neurol Neurosurg; 2006 Oct;108(7):661-9
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  • [Title] Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas.
  • BACKGROUND: Craniopharyngioma is a rare, benign epithelial brain tumor of the suprasellar region with a high rate of recurrence.
  • METHODS: We compared recurrence/regrowth of the tumors with the clinico-pathological characteristics, vascular density, cell proliferation index, and immunohistochemical profile (cytokeratins, epithelial membrane antigen [EMA], carcinoembrionary antigen [CEA], and laminin) of 47 patients with craniopharyngioma followed for more than 5 years.
  • Residual tumor after surgery, whorl-like arrays (p=0.04) and immunoreactivity for p53 (p=0.022) were significantly related to recurrence/regrowth.
  • CONCLUSIONS: Residual tumor after surgery, immunoreactivity to p53 and presence of whorl-like arrays are associated to recurrence/regrowth of craniopharyngioma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / physiopathology. Craniopharyngioma / diagnosis. Craniopharyngioma / physiopathology. Neoplasm Recurrence, Local / epidemiology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoembryonic Antigen / metabolism. Cell Proliferation. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Keratins / metabolism. Laminin / metabolism. Male. Mucin-1 / metabolism. Neovascularization, Pathologic / diagnosis. Neovascularization, Pathologic / epidemiology. Neovascularization, Pathologic / physiopathology. Predictive Value of Tests. Prognosis. Radiotherapy / statistics & numerical data. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16500745.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Laminin; 0 / Mucin-1; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
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55. Elliott RE, Hsieh K, Hochm T, Belitskaya-Levy I, Wisoff J, Wisoff JH: Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children. J Neurosurg Pediatr; 2010 Jan;5(1):30-48
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  • [Title] Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children.
  • OBJECT: Optimal treatment of primary and recurrent craniopharyngiomas remains controversial.
  • The authors report their experience with radical resection of both primary and recurrent craniopharyngiomas in children and compare the outcomes between the 2 groups.
  • METHODS: A retrospective analysis was performed in 86 children younger than 21 years of age who underwent a total of 103 operations for craniopharyngioma between 1986 and 2008; these were performed by the senior author.
  • Tumor recurred after GTR in 14 (20%) of 71 patients.
  • Factors negatively affecting overall survival and progression-free survival include subtotal resection (recurrent tumors only), tumor size >or= 5 cm, or presence of hydrocephalus or a ventriculoperitoneal shunt.
  • Prior radiation therapy and increasing tumor size were both risk factors for incomplete resection at reoperation.
  • CONCLUSIONS: In the hands of surgeons with experience with craniopharyngiomas, the authors believe that radical resection at presentation offers the best chance of disease control and potential cure with acceptable morbidity.
  • While GTR does not preclude recurrence and is more difficult to achieve in recurrent tumors, especially large and previously irradiated tumors, radical resection is still possible in patients with recurrent craniopharyngiomas with morbidity similar to that of primary tumors.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Microsurgery / methods. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery
  • [MeSH-minor] Adolescent. Adult. Body Mass Index. Child. Child, Preschool. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Hypopituitarism / diagnosis. Hypopituitarism / etiology. Hypothalamic Diseases / diagnosis. Hypothalamic Diseases / etiology. Infant. Kaplan-Meier Estimate. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Neurologic Examination. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Prognosis. Retrospective Studies. Risk Factors. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • [CommentIn] J Neurosurg Pediatr. 2010 Jan;5(1):27-8; discussion 28-9 [20043734.001]
  • (PMID = 20043735.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Hölsken A, Kreutzer J, Hofmann BM, Hans V, Oppel F, Buchfelder M, Fahlbusch R, Blümcke I, Buslei R: Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas. Brain Pathol; 2009 Jul;19(3):357-64

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  • [Title] Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas.
  • Activating beta-catenin (CTNNB1) mutations can be identified in the majority of adamantinomatous craniopharyngiomas (adaCP), suggesting an aberrant Wnt signaling pathway in this histopathologically peculiar tumor entity.
  • We performed a laser-microdissection-based study comparing beta-catenin accumulating vs. non-accumulating tumor cells.
  • Mutational analysis and gene expression profiling using real-time polymerase chain reaction were conducted in adamantinomatous and papillary tumor specimens.
  • Target gene activation, that is, over-expression of Axin2 could be detected in adaCP, especially in tumor cells with nuclear beta-catenin accumulation.
  • Interestingly, accumulating and non-accumulating tumor cell populations carried CTNNB1 mutations within exon 3.
  • [MeSH-major] Craniopharyngioma / genetics. Signal Transduction / physiology. Transcriptional Activation. Wnt Proteins / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Axin Protein. Bone Morphogenetic Protein 4 / genetics. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cytoskeletal Proteins / genetics. DNA Mutational Analysis. Female. Gene Expression. Humans. Immunohistochemistry. Male. Microdissection. Pituitary Neoplasms / genetics. Pituitary Neoplasms / metabolism. Pituitary Neoplasms / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18540944.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / AXIN2 protein, human; 0 / Axin Protein; 0 / Bone Morphogenetic Protein 4; 0 / Cytoskeletal Proteins; 0 / Wnt Proteins; 0 / beta Catenin
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57. Spoudeas HA, Saran F, Pizer B: A multimodality approach to the treatment of craniopharyngiomas avoiding hypothalamic morbidity: a UK perspective. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:447-51
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  • [Title] A multimodality approach to the treatment of craniopharyngiomas avoiding hypothalamic morbidity: a UK perspective.
  • The management of craniopharyngiomas is complex and controversial.
  • The perception that they are benign tumours cured by radical surgical resection is not borne out by their often difficult excision, propensity to recur and invade, and high late morbidity and mortality from direct brain injury.
  • Their central location makes visual or pituitary dysfunction and/or hydrocephalus common presenting features.
  • The most important consequence of craniopharyngiomas is hypothalamic injury which may result in severe, crippling and life-threatening sequelae, such as adipsia, morbid obesity, sleep, and behavioural and cognitive disorders.
  • Thus concerns regarding the potential late toxicity of radiotherapy to the developing brain need to be balanced against the recognised morbidity and mortality of recurrent tumour and repeated neurosurgical interventions.
  • National registration and management by multidisciplinary teams in specialised centres according to nationally agreed risk adapted treatment strategies are likely to improve outcomes, as has been demonstrated for example in adult pituitary tumours.
  • Because of the rarity of craniopharyngiomas, international collaborative trials are necessary to properly inform future therapies.
  • [MeSH-major] Craniopharyngioma / complications. Craniopharyngioma / therapy. Hypothalamic Diseases / etiology. Hypothalamic Diseases / prevention & control. Pituitary Neoplasms / complications. Pituitary Neoplasms / therapy

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  • (PMID = 16700323.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 38
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58. Burghaus S, Hölsken A, Buchfelder M, Fahlbusch R, Riederer BM, Hans V, Blümcke I, Buslei R: A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch; 2010 Mar;456(3):287-300
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  • [Title] A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.
  • Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants.
  • Both subtypes are classified according to the World Health Organization grade I, but their irregular digitate brain infiltration makes any complete surgical resection difficult to obtain.
  • Herein, we characterized the cellular interface between the tumor and the surrounding brain tissue in 48 CP (41 adaCP and seven papCP) compared to non-neuroepithelial tumors, i.e., 12 cavernous hemangiomas, 10 meningiomas, and 14 metastases using antibodies directed against glial fibrillary acid protein (GFAP), vimentin, nestin, microtubule-associated protein 2 (MAP2) splice variants, and tenascin-C.
  • Furthermore, the outer tumor cell layer of adaCP showed a distinct expression of MAP2, a novel finding helpful in the differential diagnosis of epithelial tumors in the sellar region.
  • Our data support the hypothesis that adaCP, unlike other non-neuroepithelial tumors of the central nervous system, create a tumor-specific cellular environment at the tumor-brain junction.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Brain / metabolism. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Nerve Tissue Proteins / metabolism. Nestin. Tenascin / metabolism. Vimentin / metabolism

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  • (PMID = 20069432.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Tenascin; 0 / Vimentin
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59. Xu J, Zhang S, You C, Huang S, Cai B, Wang X: Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. J Neurooncol; 2007 Jun;83(2):183-9
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  • [Title] Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.
  • Craniopharyngioma often recurs after resection resulting in poor outcome for the affected patients.
  • The reliable criteria for predicting the tumor behavior are still lacking.
  • It has been suggested that proliferative potential of the tumor cells is necessary for recurrence.
  • Present study evaluated the cell multiplication activity, which is possibly related to relapse in 32 patients with adamantine epithelioma (AE) and 31 patients with squamous papillary tumor (SP).
  • For this tissue specimens from their primary and recurring tumors were collected and immunohistochemical analysis of the expression of minichromosome maintenance protein 6 (MCM6) and DNA topoisomerase II alphalpha (DNA Topo II alpha) in the tumor sections was performed by quantitative microscopy.
  • There was a strong linear positive correlation between MCM6 LI and DNA Topo II alpha LI (r = 0.713; p = 0.000) in the craniopharyngiomas studied.
  • The median MCM6 LI of the total 20 recurrent craniopharyngiomas (31.49%) was not significantly different from that of their primary tumors (29.65%).
  • The long term risk of tumor recurrence is higher in AE than SP and it is associated with MCM6 and DNA Topo II alpha expression.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Brain Neoplasms / metabolism. Cell Cycle Proteins / metabolism. Craniopharyngioma / metabolism. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Neoplasm Recurrence, Local / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Proliferation. Child. Child, Preschool. Cohort Studies. Female. Humans. Immunohistochemistry. Male. Matched-Pair Analysis. Middle Aged. Minichromosome Maintenance Complex Component 6. Prospective Studies

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  • (PMID = 17410335.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; EC 3.6.4.12 / MCM6 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 6; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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60. Zhou L, Luo L, Xu J, Li Q, Chen J, Jiang S, Cai B, You C: Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes. J Neurol Neurosurg Psychiatry; 2009 Oct;80(10):1150-4
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  • [Title] Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes.
  • OBJECTIVE: Craniopharyngiomas with predominant pars in the posterior fossa are very rare and extremely overlooked.
  • The purpose of this study was to explore the differing characteristics of posterior fossa craniopharyngiomas.
  • METHODS: Seven patients with pathologically proven craniopharyngiomas located in the posterior fossa were retrospectively investigated.
  • CONCLUSIONS: Posterior fossa craniopharyngiomas are rare and may be considered an independent subgroup of classifications.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Infratentorial Neoplasms / diagnosis. Infratentorial Neoplasms / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Cohort Studies. Female. Humans. Male. Retrospective Studies. Treatment Outcome

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  • [RetractionIn] J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):942 [20682723.001]
  • (PMID = 19762904.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
  • [Publication-country] England
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61. Kitano M, Taneda M: Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach. Surg Neurol; 2009 Mar;71(3):290-8, discussion 298
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  • [Title] Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach.
  • To evaluate the capability of this approach for removal of suprasellar craniopharyngiomas, surgical outcomes were retrospectively analyzed.
  • METHODS: During a 9-year period, 20 consecutive patients with suprasellar craniopharyngioma underwent transsphenoidal tumor resection.
  • No patient had a purely intrasellar tumor, 9 had prechiasmatic tumors, 9 had retrochiasmatic tumors, and 2 had purely intraventricular tumors.
  • CONCLUSIONS: Reasonable surgical results in this study suggest that the extended transsphenoidal approach is safe and effective for removal of craniopharyngiomas.
  • Although preservation of the pituitary stalk can be achieved in a high percentage of patients, postoperative endocrinopathy still remains as a significant problem after radical removal of the craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Optic Chiasm. Pituitary Neoplasms / surgery. Sella Turcica
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pituitary Gland / surgery. Postoperative Complications. Retrospective Studies. Sphenoid Bone / surgery. Young Adult

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  • (PMID = 18291485.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Kassam AB, Gardner PA, Snyderman CH, Carrau RL, Mintz AH, Prevedello DM: Expanded endonasal approach, a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas: a new classification based on the infundibulum. J Neurosurg; 2008 Apr;108(4):715-28
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  • [Title] Expanded endonasal approach, a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas: a new classification based on the infundibulum.
  • OBJECT: Craniopharyngiomas are notoriously difficult to treat.
  • The authors explain the techniques and approach used for the endoscopic endonasal resection of suprasellar craniopharyngiomas and introduce a tumor classification scheme.
  • METHODS: The techniques and approach used for the endoscopic, endonasal resection of suprasellar craniopharyngiomas is explained, including the introduction of a tumor classification scheme.
  • Moreover, in its application for craniopharyngiomas, an understanding of tumor growth and extension with respect to the optic chiasm and infundibulum is critical to safely approach the lesion via an endonasal route.
  • [MeSH-major] Craniopharyngioma / classification. Craniopharyngioma / surgery. Neuroendoscopy / methods. Pituitary Gland, Posterior / pathology. Pituitary Neoplasms / classification. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Nasal Cavity / surgery. Neoplasm Recurrence, Local / prevention & control

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  • [CommentIn] J Neurosurg. 2009 Jul;111(1):197-9; author reply 199 [19569961.001]
  • [CommentIn] J Neurosurg. 2008 Dec;109(6):1180-2; author reply 1182-3 [19035739.001]
  • (PMID = 18377251.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Hirunpat S, Tanomkiat W, Sriprung H, Chetpaophan J: Optic tract edema: a highly specific magnetic resonance imaging finding for the diagnosis of craniopharyngiomas. Acta Radiol; 2005 Jul;46(4):419-23
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  • [Title] Optic tract edema: a highly specific magnetic resonance imaging finding for the diagnosis of craniopharyngiomas.
  • PURPOSE: To clarify the accuracy, sensitivity, and specificity of optic tract edema in the diagnosis of craniopharyngiomas.
  • The spread of edema surrounding the tumor on the coronal TSE T2-weighted images was analyzed.
  • RESULTS: Edema along the optic tracts was detected in 7 of 11 craniopharyngiomas, giving a sensitivity of 63.6% (95% CI = 30.8-89.1) for our series and 66.7% (95% CI = 47.2-82.7) for the pooled numbers.
  • None of the 28 pituitary macroadenomas, 4 meningiomas, 2 hypothalamic astrocytomas, 2 germinomas, 1 mixed-germ cell tumor and 1 arachnoid cyst in our study showed edema of the optic pathways.
  • CONCLUSION: Optic tract edema, commonly seen in craniopharyngiomas, is a useful MR finding for distinguishing craniopharyngiomas from other parasellar tumors with considerable sensitivity and high specificity.
  • [MeSH-major] Craniopharyngioma / diagnosis. Edema / diagnosis. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / diagnosis. Visual Pathways / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16134321.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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64. Dallago CM, Oliveira MC, Barbosa-Coutinho LM, Ferreira NP: Angiogenesis in craniopharyngiomas: Microvascular density and tissue expression of the vascular endothelial growth factor (VEGF) and endostatin. Endocr Pathol; 2005;16(4):355-62
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  • [Title] Angiogenesis in craniopharyngiomas: Microvascular density and tissue expression of the vascular endothelial growth factor (VEGF) and endostatin.
  • Craniopharyngiomas are benign tumors of the sellar region generally associated with endocrine abnormality and often locally aggressive.
  • The microvascular density (MVD) of craniopharyngiomas was determined in tumor tissue samples from a reference neurosurgery center located in southern Brazil using immunohistochemical methods for two endothelial markers, CD34 and CD105 (endoglin).
  • There was no association between the two endothelial markers and tumor extension.
  • We were not able to establish a relationship between angiogenesis in craniopharyngiomas and tumor extension with the endothelial markers used in this study.
  • We believe that CD105 antigen can be a more specific endothelial marker for tumor angiogenesis than CD34 antigen.
  • [MeSH-major] Craniopharyngioma / blood supply. Endostatins / metabolism. Neovascularization, Pathologic / pathology. Pituitary Neoplasms / blood supply. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Child. Endothelium, Vascular / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Receptors, Cell Surface / metabolism

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  • (PMID = 16627922.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / ENG protein, human; 0 / Endostatins; 0 / Receptors, Cell Surface; 0 / Vascular Endothelial Growth Factor A
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65. Moon SH, Kim IH, Park SW, Kim I, Hong S, Park CI, Wang KC, Cho BK: Early adjuvant radiotherapy toward long-term survival and better quality of life for craniopharyngiomas--a study in single institute. Childs Nerv Syst; 2005 Aug;21(8-9):799-807
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  • [Title] Early adjuvant radiotherapy toward long-term survival and better quality of life for craniopharyngiomas--a study in single institute.
  • OBJECTIVES: The objective of the study is to compare survival and quality of life (QoL) by the delivery time of adjuvant radiotherapy (RT), early or late, for craniopharyngiomas.
  • Initial tumor size was the only prognostic factor (p=0.034) for progression-free survival in univariate analysis.
  • Better visual acuity or field was maintained, and diabetes insipidus was partly improved with early RT, but all were deteriorated as tumor progressed without early RT.
  • Poor QoL with late RT resulted from relapsed tumor and repeated surgery but was not associated with RT itself.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Quality of Life
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Imaging, Three-Dimensional. Infant. Male. Middle Aged. Postoperative Complications. Radiosurgery. Radiotherapy Dosage. Radiotherapy, Adjuvant / methods. Retrospective Studies. Time Factors. Treatment Outcome. Vision Disorders / etiology

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  • (PMID = 15959734.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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66. Hofmann BM, Kreutzer J, Saeger W, Buchfelder M, Blümcke I, Fahlbusch R, Buslei R: Nuclear beta-catenin accumulation as reliable marker for the differentiation between cystic craniopharyngiomas and rathke cleft cysts: a clinico-pathologic approach. Am J Surg Pathol; 2006 Dec;30(12):1595-603
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  • [Title] Nuclear beta-catenin accumulation as reliable marker for the differentiation between cystic craniopharyngiomas and rathke cleft cysts: a clinico-pathologic approach.
  • Clinical and histopathologic differentiation of cystic lesions from the sellar region, that is, craniopharyngiomas (CPs) and Rathke cleft cysts (RCCs), is challenging and has paramount importance with respect to variable clinical manifestation and adapted surgical treatment strategies in both entities.
  • Here, we retrospectively evaluated clinico-pathologic findings in 81 patients presenting with a cystic tumor located in the sellar region.
  • On the basis of the histopathologic and immunohistochemical analysis, clinical presentation (sex, age, ophthalmologic, and endocrinologic deficits), imaging (tumor location, size, and calcification), as well as a description of cyst contents obtained during operation were retrospectively evaluated.
  • In purely cystic CPs, an isointense signal was more frequent in T1-weighted magnetic resonance images and calcification of the tumor capsule in computed tomography scans.
  • In addition, the size of RCC was smaller and this tumor entity was more often located within the sella.
  • Aberrant (nuclear) immunohistochemical staining for beta-catenin appeared, however, as most reliable factor for the differentiation between purely cystic CPs and RCCs, whereas tumor location, tumor size, and calcification of the tumor capsule were less consistent parameters.
  • [MeSH-major] Cell Nucleus / metabolism. Central Nervous System Cysts / pathology. Craniopharyngioma / pathology. Pituitary Neoplasms / pathology. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17122517.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / beta Catenin
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67. Bojanowski K, Marchel A: [Long-term result of the surgical treatment of craniopharyngiomas]. Neurol Neurochir Pol; 2006 Nov-Dec;40(6):478-82; discussion 483
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  • [Title] [Long-term result of the surgical treatment of craniopharyngiomas].
  • CONCLUSIONS: On the basis of our own experience we conclude that complete removal of the craniopharyngioma leads to the best outcome in terms of survival time and period free of recurrence.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Disease-Free Survival. Female. Humans. Male. Middle Aged. Reoperation. Survival Rate. Treatment Outcome

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  • (PMID = 17199173.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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68. Tanaka Y, Takemae T, Kobayashi S, Sakai K, Miyahara T, Ishizaka S, Kodama K, Kobayashi T, Ichikawa Y, Tsutsumi K, Hongo K: [Clinical analysis of treatment and long-term outcome in 56 craniopharyngiomas]. No Shinkei Geka; 2007 Sep;35(9):887-93
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  • [Title] [Clinical analysis of treatment and long-term outcome in 56 craniopharyngiomas].
  • In order to improve QOL in patients with craniopharyngioma, retrospective analysis was performed to discover factors for influencing functional outcome and the best treatment strategy.
  • Subtotal tumor resection with prophylactic radiation was performed in 8 patients (Group D).
  • Tumor recurrence was noted in 19 patients and stereotactic radiation or 2nd operation was performed in 11 patients (Group B).
  • Factors leading to poor outcome included extrasellar origin, solid tumor, bad score before treatment, 2nd surgery for recurrence.
  • Maximum tumor removal should be attempted with functional preservation.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Treatment Outcome

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  • (PMID = 17867308.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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69. Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnrübl F, Hahnen E, Kreutzer J, Fahlbusch R: Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathol; 2005 Jun;109(6):589-97
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  • [Title] Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region.
  • Here, we examined beta-catenin and adenomatous polyposis coli (APC) by mutational analysis in pituitary adenomas (n=60) and a large series of craniopharyngiomas (n=41).
  • Furthermore, the expression pattern of beta-catenin was immunohistochemically analysed in a cohort of tumours and cysts of the sellar region including pituitary adenomas (n=58), craniopharyngiomas (n=57), arachnoidal cysts (n=8), Rathke's cleft cysts (n=10) and xanthogranulomas (n=6).
  • Whereas APC mutations were not detectable in any tumour entity, beta-catenin mutations were present in 77% of craniopharyngiomas, exclusively of the adamantinomatous subtype.
  • We conclude that beta-catenin mutations and/or nuclear accumulation serve as diagnostic hallmarks of the adamantinomatous variant, setting it apart from the papillary variant of craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / genetics. Cytoskeletal Proteins / genetics. Genes, APC. Pituitary Neoplasms / genetics. Sella Turcica / pathology. Trans-Activators / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Child. Child, Preschool. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mutation. Polymorphism, Single-Stranded Conformational. Reverse Transcriptase Polymerase Chain Reaction. beta Catenin

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  • (PMID = 15891929.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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70. Campanini ML, Colli LM, Paixao BM, Cabral TP, Amaral FC, Machado HR, Neder LS, Saggioro F, Moreira AC, Antonini SR, de Castro M: CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas. Horm Cancer; 2010 Aug;1(4):187-96
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  • [Title] CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas.
  • Genes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis.
  • The objective of this study is to perform the molecular analysis of HESX1, PROP1, POU1F1, and CTNNB1 genes and evaluate a panel of miRNA expression in craniopharyngioma.
  • The study included 16 patients with adamantinomatous craniopharyngioma (nine children and seven adults; eight females and eight males; 6-55 years, median 15.5 years).
  • DNA, RNA, and cDNA were obtained from craniopharyngioma and normal pituitaries.
  • We found no mutations in HESX1, PROP1, and POU1F1 genes and four polymorphisms in PROP1 gene which were in Hardy-Weinberg equilibrium and had similar allelic frequencies in craniopharyngioma and controls.
  • We observed hyperexpression of miR-150 (1.7-fold); no different expression of miR-16-1, miR-21, and miR23a; and an underexpression of miR-141, let-7a, miR-16, miR-449, miR-145, miR-143, miR-23b, miR-15a, and miR-24-2 (ranging from -7.5 to -2.5-fold; p = 0.02) in craniopharyngioma.
  • There was no association between tumor size or the recurrence and the presence of CTNNB1mutations. miR-16 and miR-141 were underexpressed in craniopharyngioma presenting CTNNB1 mutations. miR-23a and miR24-2 were hyperexpressed in patients who underwent only one surgery.
  • Mutations or polymorphisms in pituitary transcription factors are unlikely to contribute to the adamantinomatous craniopharyngioma pathogenesis, differently of CTNNB1 mutations.
  • Our data suggest the potential involvement of the deregulation of miRNA expression in the craniopharyngioma pathogenesis and outcome and also that the miRNA could modulate the Wnt signaling pathway in craniopharyngioma tumorigenesis.
  • [MeSH-major] Craniopharyngioma / genetics. MicroRNAs / genetics. Pituitary Neoplasms / genetics. Transcription Factors / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Gene Frequency. Genetic Predisposition to Disease. Genotype. Homeodomain Proteins / genetics. Humans. Male. Middle Aged. Mutation. Pituitary Gland / metabolism. Pituitary Gland / pathology. Polymorphism, Single Nucleotide. Transcription Factor Pit-1 / genetics. Young Adult

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  • (PMID = 21761366.001).
  • [ISSN] 1868-8500
  • [Journal-full-title] Hormones & cancer
  • [ISO-abbreviation] Horm Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / HESX1 protein, human; 0 / Homeodomain Proteins; 0 / MicroRNAs; 0 / POU1F1 protein, human; 0 / Prophet of Pit-1 protein; 0 / Transcription Factor Pit-1; 0 / Transcription Factors; 0 / beta Catenin
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71. Enchev Y, Ferdinandov D, Kounin G, Encheva E, Bussarsky V: Radiation-induced gliomas following radiotherapy for craniopharyngiomas: a case report and review of the literature. Clin Neurol Neurosurg; 2009 Sep;111(7):591-6
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  • [Title] Radiation-induced gliomas following radiotherapy for craniopharyngiomas: a case report and review of the literature.
  • The aim of this study was to collect, describe and analyze the radiation-induced gliomas in craniopharyngioma patients reported in the literature up to date.
  • Although exceptionally rare, the radiation-induced gliomas in craniopharyngioma patients are potentially possible, long-term complications with devastating consequences in typically younger patients with long life-expectancy.
  • [MeSH-major] Brain Neoplasms / complications. Brain Neoplasms / radiotherapy. Craniopharyngioma / complications. Craniopharyngioma / radiotherapy. Neoplasms, Radiation-Induced / pathology. Oligodendroglioma / etiology. Oligodendroglioma / pathology
  • [MeSH-minor] Adult. Female. Humans. Iatrogenic Disease. Magnetic Resonance Imaging. Paresis. Seizures / etiology. Tomography, X-Ray Computed

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  • (PMID = 19447544.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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72. Minniti G, Saran F, Traish D, Soomal R, Sardell S, Gonsalves A, Ashley S, Warrington J, Burke K, Mosleh-Shirazi A, Brada M: Fractionated stereotactic conformal radiotherapy following conservative surgery in the control of craniopharyngiomas. Radiother Oncol; 2007 Jan;82(1):90-5
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  • [Title] Fractionated stereotactic conformal radiotherapy following conservative surgery in the control of craniopharyngiomas.
  • PURPOSE: To describe the technique and results of stereotactically guided conformal radiotherapy (SCRT) in patients with craniopharyngioma after conservative surgery.
  • METHODS AND MATERIALS: Thirty-nine patients with craniopharyngioma aged 3-68 years (median age 18 years) were treated with SCRT between June 1994 and January 2003.
  • Twelve patients (30%) had acute clinical deterioration due to cystic enlargement of craniopharyngioma following SCRT and required cyst aspiration.
  • CONCLUSION: SCRT as a high-precision technique of localized RT is suitable for the treatment of incompletely excised craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiotherapy, Conformal / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Disease-Free Survival. Dose Fractionation. Female. Follow-Up Studies. Humans. Hypothalamus / radiation effects. Male. Middle Aged. Pituitary Gland / radiation effects. Radiotherapy Planning, Computer-Assisted. Radiotherapy, Adjuvant. Treatment Outcome. Vision, Ocular / radiation effects

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  • (PMID = 17161483.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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73. Dekkers OM, Biermasz NR, Smit JW, Groot LE, Roelfsema F, Romijn JA, Pereira AM: Quality of life in treated adult craniopharyngioma patients. Eur J Endocrinol; 2006 Mar;154(3):483-9
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  • [Title] Quality of life in treated adult craniopharyngioma patients.
  • A reduced QoL has been reported in childhood-onset craniopharyngioma; however, reports of QoL in adult craniopharyngioma patients are scarce.
  • In the present study, we assessed QoL in adult patients successfully treated for craniopharyngioma in our centre.
  • METHODS: In this study, we assessed QoL in 29 adult patients in remission during long-term follow-up after treatment for craniopharyngioma.
  • CONCLUSION: Adult patients treated for craniopharyngioma show persistent impairment in QoL, especially in the physical subscales.

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  • (PMID = 16498063.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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74. Olowoyeye OA, Bankole OB: Craniopharyngioma causing visual loss in an adult. Nig Q J Hosp Med; 2008 Jan-Mar;18(1):30-1
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  • [Title] Craniopharyngioma causing visual loss in an adult.
  • Craniopharyngiomas are usually benign tumours, commonly seen in children.
  • This is a case of craniopharyngioma resulting in visual loss in an adult.
  • [MeSH-major] Blindness / etiology. Craniopharyngioma / complications. Pituitary Neoplasms / complications
  • [MeSH-minor] Adult. Hallucinations. Humans. Male. Tomography, Spiral Computed

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  • (PMID = 19062468.001).
  • [ISSN] 0189-2657
  • [Journal-full-title] Nigerian quarterly journal of hospital medicine
  • [ISO-abbreviation] Nig Q J Hosp Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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75. Daousi C, Dunn AJ, Foy PM, MacFarlane IA, Pinkney JH: Endocrine and neuroanatomic features associated with weight gain and obesity in adult patients with hypothalamic damage. Am J Med; 2005 Jan;118(1):45-50
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  • [Title] Endocrine and neuroanatomic features associated with weight gain and obesity in adult patients with hypothalamic damage.
  • Much less information is available on adult patients and long-term survivors.
  • The aims of this study were to estimate the prevalence of obesity in adult patients with acquired structural hypothalamic damage and to define the characteristics of patients at greatest risk of obesity.
  • These included 22 craniopharyngiomas, 24 pituitary adenomas, and six other hypothalamic tumors.
  • Changes in body mass index were determined, magnetic resonance imaging scans were scored by a radiologist for tumor size and the extent of involvement of the hypothalamus, and current hormone replacement therapy was recorded, to identify possible features associated with new or worsened obesity (defined as a body mass index > or =30 kg/m(2) at the latest follow-up, which had increased by at least 2 kg/m(2) since diagnosis of the tumor).
  • No correlation was found between the initial size or location of the tumor and subsequent weight gain.
  • CONCLUSION: Obesity is highly prevalent in adult survivors of hypothalamic tumors.
  • Use of desmopressin and growth hormone therapy, but not size or location of the tumor, were associated with weight gain and obesity following diagnosis.
  • [MeSH-minor] Adolescent. Adult. Aged. Body Mass Index. Confidence Intervals. Deamino Arginine Vasopressin / administration & dosage. Deamino Arginine Vasopressin / adverse effects. Female. Growth Hormone / administration & dosage. Growth Hormone / adverse effects. Humans. Male. Middle Aged. Multivariate Analysis. Odds Ratio. Prevalence. Renal Agents / administration & dosage. Renal Agents / adverse effects. Retrospective Studies

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  • (PMID = 15639209.001).
  • [ISSN] 0002-9343
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Renal Agents; 9002-72-6 / Growth Hormone; ENR1LLB0FP / Deamino Arginine Vasopressin
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76. Gapstur R, Gross CR, Ness K: Factors associated with sleep-wake disturbances in child and adult survivors of pediatric brain tumors: a review. Oncol Nurs Forum; 2009 Nov;36(6):723-31
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  • [Title] Factors associated with sleep-wake disturbances in child and adult survivors of pediatric brain tumors: a review.
  • PURPOSE/OBJECTIVES: To identify factors associated with sleep-wake disturbances in pediatric and adult survivors (aged older than 18 years) of pediatric brain tumors.
  • The search and a personal communication with one author discovered 25 English-language research articles and case reports describing sleep-wake patterns in brain tumor survivors from 1966-2008.
  • This contributes to decreased daytime alertness, which remains the most reported sleep-wake disturbance in brain tumor survivors.
  • Patients with craniopharyngiomas, radiation dose more than 3,500 cGy, and younger age at time of treatment experienced more severe sleep dysfunction.
  • CONCLUSIONS: Patients with brain tumors experience a disruption of sleep-wake patterns associated with major dysfunction in the hypothalamic-pituitary axis, affecting both Process S (homeostasis) and Process C (circadian) from the Two-Process Model of Sleep Regulation.
  • IMPLICATIONS FOR NURSING: Current sleep literature has identified patterns of sleep disturbances in cross-sectional studies of brain tumor survivors.
  • [MeSH-major] Brain Neoplasms / nursing. Oncology Nursing. Pediatric Nursing. Sleep Disorders, Circadian Rhythm / nursing
  • [MeSH-minor] Adult. Child. Humans. Survivors

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  • (PMID = 19887361.001).
  • [ISSN] 1538-0688
  • [Journal-full-title] Oncology nursing forum
  • [ISO-abbreviation] Oncol Nurs Forum
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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77. Linnert M, Gehl J: Bleomycin treatment of brain tumors: an evaluation. Anticancer Drugs; 2009 Mar;20(3):157-64
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  • [Title] Bleomycin treatment of brain tumors: an evaluation.
  • Bleomycin has been used in the treatment of brain tumors for over 30 years.
  • Currently, we are evaluating electrochemotherapy (the use of electric pulses to enhance uptake of bleomycin) for patients with secondary brain tumors.
  • Using the keywords 'brain' and 'bleomycin', a database search without date restriction was performed and over 500 articles were found.
  • Twenty-five articles were used for this study based on relevance determined by: (i) clinical studies, (ii) use of bleomycin, and (iii) direct injection into brain tissue or cysts.
  • There were two main indications for the use of bleomycin directly into the brain: (i) cystic tumors in the form of craniopharyngiomas and (ii) solid brain tumors such as glioblastomas and astrocytomas.
  • All cases with severe and moderate adverse effects except one were patients with craniopharyngiomas and probably because of tumor localization in the deep brain.
  • In conclusion, bleomycin injection into the brain has been fairly well tolerated at doses much higher than that used in electrochemotherapy.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Brain Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Blindness / chemically induced. Brain Edema / chemically induced. Child. Child, Preschool. Craniopharyngioma / drug therapy. DNA Damage. Deafness / chemically induced. Electroporation. Female. Glioma / drug therapy. Humans. Infant. Injections, Spinal. Male. Middle Aged. Pituitary Neoplasms / drug therapy. Young Adult

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  • (PMID = 19396014.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 11056-06-7 / Bleomycin
  • [Number-of-references] 43
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78. Kyrgiannis K, Mourgela S, Karamanakos PN, Liaropoulos K, Papadakis N: Optimal treatment of a recurrent giant craniopharyngioma: lessons from a case. J BUON; 2008 Oct-Dec;13(4):593-6
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  • [Title] Optimal treatment of a recurrent giant craniopharyngioma: lessons from a case.
  • A case of a 33-year-old man presented with symptoms of dramatic deterioration of the level of consciousness because of a recurrence of a previously aspirated and irradiated craniopharyngioma is described.
  • The tumor had grown enormously in dimensions and was extending in the region of hypothalamus, third ventricle and brain stem, with signs of local compression and obstructive hydrocephalus.
  • We conclude that in expert hands, microsurgery aiming at total removal should be the therapeutic option for the treatment of recurrent as well as primary craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 19145689.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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79. Qiu SJ, Guo YL, Zhang XL, Zhang F, Zhang YZ, Wen G, Hu BS: [Imaging findings of craniopharyngioma in relation to its surgical management: a retrospective analysis]. Nan Fang Yi Ke Da Xue Xue Bao; 2007 Jul;27(7):980-2
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  • [Title] [Imaging findings of craniopharyngioma in relation to its surgical management: a retrospective analysis].
  • Of the 123 craniopharyngioma patients, 59 were found to have adamantinous craniopharyngiomas, 41 had papillary squamous craniopharyngiomas, and 23 had mixed tumors.
  • Solid tumor was found in 18 cases, cystic tumor in 38 cases, and calcification in 78 cases; in 23 cases, the posterior of the tumor did not exhibit clear boundary from the wall of the three cerebral ventricles, and in 11 cases CT and MRI displayed hypophysial stalk, which was found intraoperatively in 53 cases.
  • CONCLUSIONS: MRI allows clear vision of the range of craniopharyngioma involvement and the anatomical structures surrounding the tumor.
  • Accurate identification of the site, dimension, calcification patterns and relation between the hypophysial stalk and hypothalamus by the imaging modalities significantly benefits the optimization of the surgical plan for the tumor.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cohort Studies. Female. Humans. Infant. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 17666331.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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80. Pereira AM, Schmid EM, Schutte PJ, Voormolen JH, Biermasz NR, van Thiel SW, Corssmit EP, Smit JW, Roelfsema F, Romijn JA: High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma. Clin Endocrinol (Oxf); 2005 Feb;62(2):197-204
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  • [Title] High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma.
  • INTRODUCTION: The treatment of craniopharyngiomas is associated with long-term morbidity.
  • AIM OF THE STUDY: To assess the long-term functional outcome and mortality rates after treatment for craniopharyngiomas, we audited our data with special focus on cardiovascular, neurological and psychosocial morbidity.
  • PATIENTS AND METHODS: Between 1965 and 2002, 54 consecutive patients underwent surgery for craniopharyngiomas at the Leiden University Medical Centre (LUMC).
  • CONCLUSION: Craniopharyngioma is associated with excessive long-term multisystem morbidity and mortality, especially in female patients, despite a high cure rate.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Cardiovascular Diseases / etiology. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Morbidity. Neoplasm Recurrence, Local. Nervous System Diseases / etiology. Prevalence. Risk. Sex Factors. Survival Rate. Time Factors. Visual Acuity. Visual Fields

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  • (PMID = 15670196.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 30
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81. Metzler-Baddeley C, Jones RW: Brief communication: cognitive rehabilitation of executive functioning in a case of craniopharyngioma. Appl Neuropsychol; 2010 Oct;17(4):299-304
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  • [Title] Brief communication: cognitive rehabilitation of executive functioning in a case of craniopharyngioma.
  • Craniopharyngiomas are rare brain tumors within the area of the craniopharyngeal duct.
  • This single-case report describes a brief investigation into the effectiveness of goal management training for dysexecutive problems following the removal and treatment of a craniopharyngioma in a young woman.
  • Thus, the exploitation of naturally occurring external distractions as periodic alerts to facilitate goal management can be an effective and easy-to-adopt cognitive rehabilitation strategy for dysexecutive problems associated with craniopharyngioma.
  • [MeSH-major] Cognition Disorders / rehabilitation. Cognitive Therapy / methods. Craniopharyngioma / complications. Craniopharyngioma / rehabilitation. Executive Function / physiology
  • [MeSH-minor] Adult. Female. Humans. Neuropsychological Tests

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  • (PMID = 21154044.001).
  • [ISSN] 1532-4826
  • [Journal-full-title] Applied neuropsychology
  • [ISO-abbreviation] Appl Neuropsychol
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Mahmoud OM, Tominaga A, Amatya VJ, Ohtaki M, Sugiyama K, Saito T, Sakoguchi T, Kinoshita Y, Shrestha P, Abe N, Akiyama Y, Takeshima Y, Arita K, Kurisu K, Yamasaki F: Role of PROPELLER diffusion weighted imaging and apparent diffusion coefficient in the diagnosis of sellar and parasellar lesions. Eur J Radiol; 2010 Jun;74(3):420-7
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  • RESULTS: ADC-MIN of hemorrhagic pituitary adenomas was lower than of the other lesions with similar appearance on conventional MRI (non-hemorrhagic pituitary adenomas, craniopharyngiomas, Rathke's cleft cysts; accuracy 100%); the useful cut-off value was 0.700 x 10(-3)mm(2)/s.
  • ADC-MIN of craniopharyngiomas was lower than of Rathke's cleft cysts (accuracy 100%; p<0.05).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Image Enhancement / methods. Male. Middle Aged. Reproducibility of Results. Sella Turcica / pathology. Sensitivity and Specificity. Young Adult

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19394778.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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83. Tena-Suck ML, Ortiz-Plata A, Galán F, Sánchez A: Expression of epithelial cell adhesion molecule and pituitary tumor transforming gene in adamantinomatous craniopharyngioma and its correlation with recurrence of the tumor. Ann Diagn Pathol; 2009 Apr;13(2):82-8
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  • [Title] Expression of epithelial cell adhesion molecule and pituitary tumor transforming gene in adamantinomatous craniopharyngioma and its correlation with recurrence of the tumor.
  • Craniopharyngiomas are benign tumors of the sellar region generally associated with endocrine disorders and often locally aggressive.
  • The reliable criteria for predicting the tumor behavior are still lacking.
  • It has been suggested that proliferative potential of the tumor cells is necessary for recurrence.
  • The aim of this study was to evaluate the activity and correlation of epithelial cell adhesion molecule (Ep-CAM) and pituitary tumor transforming gene (PTTG-1) immunoexpression that is possibly related to relapse in 40 patients with adamantinomatous craniopharyngioma.
  • The PTGG-1 expression in craniopharyngioma may suggest hypophyseal metaplasia.
  • The Ep-CAM and PTTG-1 expression in craniopharyngioma could be used as prediction markers of relapsing tumor.
  • It has been suggested that proliferative potential of the tumor cells is necessary for recurrence.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Cell Adhesion Molecules / biosynthesis. Craniopharyngioma / metabolism. Neoplasm Proteins / biosynthesis. Neoplasm Recurrence, Local / metabolism. Pituitary Neoplasms / metabolism
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Gene Expression. Humans. Immunohistochemistry. Male. Securin

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  • [CommentIn] Ann Diagn Pathol. 2009 Dec;13(6):428-9 [19917481.001]
  • (PMID = 19302955.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human; 0 / Neoplasm Proteins; 0 / Securin; 0 / pituitary tumor-transforming protein 1, human
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84. Bianco Ade M, Madeira LV, Rosemberg S, Shibata MK: Cortical seeding of a craniopharyngioma after craniotomy: Case report. Surg Neurol; 2006 Oct;66(4):437-40; discussion 440
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  • [Title] Cortical seeding of a craniopharyngioma after craniotomy: Case report.
  • BACKGROUND: Cortical seeding of a craniopharyngioma has been rarely reported.
  • METHODS: A 27-year-old woman presented earlier with a suprasellar craniopharyngioma.
  • A left frontotemporal craniotomy was done with subtotal resection of the tumor because it was strongly adhered to the optic chiasm.
  • Histopathology confirmed the diagnosis of craniopharyngioma.
  • Magnetic resonance imaging revealed a contrast-enhancing tumor with cystic and solid components on the left temporal lobe cortex.
  • The primary tumor bed was intact.
  • The patient was reoperated, and the temporal lobe tumor was totally removed.
  • Histologic studies showed an adamantinomatous craniopharyngioma.
  • CONCLUSIONS: Although craniopharyngiomas exhibit a benign histopathologic pattern, a total resection combined with careful inspection and irrigation of the surgical field is the optimal treatment for preventing local and ectopic recurrences.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Seeding. Pituitary Neoplasms / pathology. Temporal Lobe / pathology
  • [MeSH-minor] Adult. Craniotomy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Optic Chiasm / pathology. Optic Chiasm / physiopathology. Seizures / etiology. Seizures / physiopathology. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 17015135.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Yin J, Su CB, Xu ZQ, Xia XW, Song F: Reconstruction of the sellar floor following transsphenoidal surgery using gelatin foam and fibrin glue. Chin Med Sci J; 2005 Sep;20(3):198-201
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  • METHODS: A total of 176 consecutive patients who underwent surgery for pituitary adenomas, cysts, chordomas, or subdiaphragmatic craniopharyngiomas in the sella turcica between January 2001 and April 2003 at Peking Union Medical College Hospital were enrolled.

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  • (PMID = 16261893.001).
  • [ISSN] 1001-9294
  • [Journal-full-title] Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
  • [ISO-abbreviation] Chin. Med. Sci. J.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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86. Saeki N, Murai H, Hasegawa Y, Horiguchi K, Hanazawa T, Fukuda K: [Endoscopic endonasal surgery for extrasellar tumors: case presentation and its future perspective]. No Shinkei Geka; 2009 Mar;37(3):229-46
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  • BACKGROUND AND OBJECTIVES: Endoscopic endonasal transsphenoidal surgery has been performed because of its advantages such as less invasive surgical management and more aggressive tumor removal of extrasellar lesions.
  • In cases with meningiomas, craniopharyngiomas and giant pituitary adenomas, which needed intra-dural procedure, nasal procedures such as middle nasal conchotomy, posterior ethmoidectomy and skull base techniques such as optic canal decompression and removal of the planum sphenoidale were carried out to gain the wider operative field toward anterior skull base and lower clivus.
  • Angled endoscope attained more successful removal of tumor under direct visualization extending into the cavernous sinus (GH secreting ademomas) and lower clivus (chordoma).
  • In the combination of such techniques, a lumbar drainage system to prevent postoperative CSF rhinorrhea became needless in many cases.
  • [MeSH-major] Adenoma / surgery. Craniopharyngioma / surgery. Meningioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Intraoperative Complications. Male. Middle Aged. Neuroendoscopy / methods. Posture. Skull Base

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  • (PMID = 19306643.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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87. Suri A, Narang KS, Sharma BS, Mahapatra AK: Visual outcome after surgery in patients with suprasellar tumors and preoperative blindness. J Neurosurg; 2008 Jan;108(1):19-25
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  • There were 37 cases of pituitary adenomas, 19 craniopharyngiomas, 18 meningiomas, and 5 other tumors.
  • Patients underwent either transcranial or transsphenoidal tumor decompression.
  • Bivariate analysis revealed male sex, shorter duration of blindness, presence of apoplexy, sellar tumor extension, soft tumor consistency, operative evidence of hemorrhage in tumor, and tumor histopathology (pituitary adenoma) to have significant impact on the outcome.
  • [MeSH-major] Blindness / physiopathology. Blindness / surgery. Brain Neoplasms / pathology. Brain Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Evoked Potentials, Visual / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Recovery of Function / physiology. Retrospective Studies. Treatment Outcome. Visual Acuity / physiology. Visual Fields / physiology. Visual Perception / physiology

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  • (PMID = 18173306.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Idowu OE, Apemiye RA: Delay in presentation and diagnosis of adult primary intracranial neoplasms in a tropical teaching hospital: a pilot study. Int J Surg; 2009 Aug;7(4):396-8
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  • [Title] Delay in presentation and diagnosis of adult primary intracranial neoplasms in a tropical teaching hospital: a pilot study.
  • Sixty-three adult patients with intracranial neoplasms were studied prospectively over a 2 year period.
  • Meningiomas (30%), Pituitary tumours (18%), High-grade gliomas (14%) and craniopharyngiomas (8%) were the most common brain tumours.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / mortality. Cause of Death. Health Services Accessibility. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Needle. Developing Countries. Early Detection of Cancer. Female. Hospitals, Teaching. Humans. Immunohistochemistry. Male. Middle Aged. Needs Assessment. Neoplasm Staging. Nigeria. Pilot Projects. Prospective Studies. Risk Assessment. Survival Analysis. Time Factors. Tropical Climate. Young Adult

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  • [CommentIn] Int J Surg. 2009 Oct;7(5):485 [19635600.001]
  • (PMID = 19595802.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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89. Krysiak R, Okopień B, Szkróbka W: [Etiology, histopathological picture and clinical presentation of craniopharyngioma]. Pol Merkur Lekarski; 2008 Aug;25(146):175-8
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  • [Title] [Etiology, histopathological picture and clinical presentation of craniopharyngioma].
  • Craniopharyngioma is a rare, benign, suprasellar brain tumour accounting for about 1 to 3% of all intracranial neoplasms.
  • In this paper, the authors review different aspects of pathology, and clinical presentation of the craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / pathology. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adult. Humans

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  • (PMID = 18942342.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 27
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90. Kobayashi T, Kida Y, Mori Y, Hasegawa T: Long-term results of gamma knife surgery for the treatment of craniopharyngioma in 98 consecutive cases. J Neurosurg; 2005 Dec;103(6 Suppl):482-8
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  • [Title] Long-term results of gamma knife surgery for the treatment of craniopharyngioma in 98 consecutive cases.
  • OBJECT: The authors analyzed the long-term outcomes of gamma knife surgery (GKS) for residual or recurrent craniopharyngiomas after microsurgery and the effects of dose reduction.
  • METHODS: A total of 107 patients with craniopharyngiomas were treated with GKS at Komaki City Hospital during the past 12 years, and 98 patients were followed up for 6 to 148 months (mean 65.5 months).
  • The mean tumor diameter and volume were 18.8 mm and 3.5 ml, respectively.
  • These tumors were treated with a maximal dose of 21.8 Gy and a tumor margin dose of 11.5 Gy by using a mean of 4.5 isocenters.
  • Final overall response rates were as follows: complete response 19.4%, partial response 67.4%, tumor control 79.6%, and tumor progression 20.4%.
  • Reducing the tumor margin dose resulted in decreased therapeutic response and increased tumor progression, although the rate of visual and pituitary function loss also decreased.
  • Among the factors examined, age (for adults) and the nature of the tumor (cystic or mixed) were statistically significant favorable and unfavorable prognostic factors, respectively.
  • CONCLUSIONS: Stereotactic GKS is safe and effective, in the long term, as an adjuvant or boost therapy for residual or recurrent craniopharyngiomas after surgical removal and has minimal side effects.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Disease Progression. Female. Humans. Longitudinal Studies. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Stereotaxic Techniques. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2006 Aug;105(2 Suppl):159-60; author reply 160 [16922083.001]
  • (PMID = 16383245.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Sands SA, Milner JS, Goldberg J, Mukhi V, Moliterno JA, Maxfield C, Wisoff JH: Quality of life and behavioral follow-up study of pediatric survivors of craniopharyngioma. J Neurosurg; 2005 Oct;103(4 Suppl):302-11
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  • [Title] Quality of life and behavioral follow-up study of pediatric survivors of craniopharyngioma.
  • OBJECT: The authors set out to evaluate the quality of life (QOL), social-emotional functioning, and behavioral functioning of children treated surgically for craniopharyngiomas.
  • After a mean follow-up period of 6.8 +/- 3.5 years, these 29 patients were administered either the 36-item Short Form Health Survey version 2 or the Child Health Questionnaire-Parent Form to assess QOL, as well as the Achenbach Child Behavior Checklist or Young Adult Checklist to measure social-emotional and behavioral functioning.
  • Further analyses indicated that retrochiasmatic tumor location, recurrence, and additional surgery were associated with poorer outcomes.
  • In contrast, hydrocephalus, tumor size, and sex were not prognostic variables, and patients significantly improved as post-operative time increased.
  • CONCLUSIONS: Attention toward late effects arising after the treatment of pediatric craniopharyngioma, including decreased postoperative physical health and behavioral functioning, is warranted.
  • Future approaches to treatment should consider the documented effects of either gross-total resection or limited surgery followed by cranial irradiation on QOL, with specific evaluation for those with retrochiasmatic tumors, a recurrent tumor, or the need for additional surgery.
  • [MeSH-major] Child Behavior. Craniopharyngioma / surgery. Pituitary Neoplasms / surgery. Quality of Life. Social Behavior
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Humans. Male. Postoperative Complications

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  • [CommentIn] J Neurosurg. 2005 Oct;103(4 Suppl):297-8; discussion 298 [16270679.001]
  • (PMID = 16270681.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Yano S, Tsuiki H, Kudo M, Kai Y, Morioka M, Takeshima H, Yumoto E, Kuratsu J: Sellar repair with resorbable polyglactin acid sheet and fibrin glue in endoscopic endonasal transsphenoidal surgery. Surg Neurol; 2007 Jan;67(1):59-64; discussion 64
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  • METHODS: The sellar repair using absorbable PGA sheet and fibrin glue was applied to 18 consecutive patients with sellar tumors that include 13 pituitary adenomas, 2 craniopharyngiomas, 2 Rathke's cleft cysts, and 1 meningioma within 135 patients who were treated with endoscopic endonasal transsphenoidal approach.
  • [MeSH-minor] Adenoma / surgery. Adult. Aged. Craniopharyngioma / surgery. Endoscopy. Female. Follow-Up Studies. Humans. Male. Meningioma / surgery. Middle Aged. Sphenoid Sinus / surgery

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  • (PMID = 17210302.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives; 34346-01-5 / Polyglactin 910
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93. Müller HL, Gebhardt U, Etavard-Gorris N, Kolb R, Warmuth-Metz M, Sörensen N: Current strategies in diagnostics and endocrine treatment of patients with childhood craniopharyngioma during follow-up--recommendations in KRANIOPHARYNGEOM 2000. Onkologie; 2005 Mar;28(3):150-6
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  • [Title] Current strategies in diagnostics and endocrine treatment of patients with childhood craniopharyngioma during follow-up--recommendations in KRANIOPHARYNGEOM 2000.
  • Craniopharyngiomas are rare dysontogenetic malformations.
  • As the survival rate after craniopharyngioma diagnosed during childhood and adolescence is high, prognosis and quality of life (QoL) in survivors mainly depend on adverse late effects such as hypopituitarism and obesity.
  • In order to evaluate and standardize diagnostic and therapeutical strategies in childhood craniopharyngioma the prospective multicenter surveillance study KRANIOPHARYNGEOM 2000 was initiated for patients diagnosed with craniopharyngioma during childhood and adolescence.
  • We are reporting on current strategies for laboratory diagnostics and endocrine substitution in patients with childhood craniopharyngioma recruited in KRANIOPHARYNGEOM 2000.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Diabetes Insipidus, Neurogenic / diagnosis. Diabetes Insipidus, Neurogenic / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Female. Germany. Humans. Infant. Infant, Newborn. Male. Obesity / diagnosis. Obesity / etiology. Obesity / therapy. Practice Guidelines as Topic. Practice Patterns, Physicians'. Treatment Outcome

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  • (PMID = 15772466.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 24
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94. Holmer H, Ekman B, Björk J, Nordstöm CH, Popovic V, Siversson A, Erfurth EM: Hypothalamic involvement predicts cardiovascular risk in adults with childhood onset craniopharyngioma on long-term GH therapy. Eur J Endocrinol; 2009 Nov;161(5):671-9
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  • [Title] Hypothalamic involvement predicts cardiovascular risk in adults with childhood onset craniopharyngioma on long-term GH therapy.
  • CONTEXT: Craniopharyngioma patients without GH therapy are at an increased cardiovascular disease (CVD) risk and particularly concerning women.
  • No previous study on long-term GH therapy in adults with childhood onset (CO) craniopharyngioma was identified.
  • OBJECTIVE: To investigate CVD risk in adults with CO craniopharyngioma on complete hormone replacement, including long-term GH therapy, and to investigate the impact of disease-related factors on CVD risk.
  • DESIGN AND PARTICIPANTS: In a cross-sectional study of operated CO craniopharyngiomas (1958-2000) from a defined area of Sweden (2.5 million), we enrolled 42 patients (20 women) with a median age of 28 years (range 17-57) and assessed CVD risk of 20 (4-40) years after first operation.
  • Comparisons were made with matched controls and between patients with tumor growth into the third ventricle (TGTV) versus non-TGTV.
  • CONCLUSIONS: Adult patients with CO craniopharyngioma, especially those with TGTV, have persistently increased CVD risk.

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  • (PMID = 19667040.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Insulin; 0 / Leptin; 12629-01-5 / Human Growth Hormone
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95. Karavitaki N, Warner JT, Marland A, Shine B, Ryan F, Arnold J, Turner HE, Wass JA: GH replacement does not increase the risk of recurrence in patients with craniopharyngioma. Clin Endocrinol (Oxf); 2006 May;64(5):556-60
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  • [Title] GH replacement does not increase the risk of recurrence in patients with craniopharyngioma.
  • BACKGROUND: A significant number of patients with craniopharyngioma are GH deficient.
  • OBJECTIVE: To assess the effect of GH replacement upon recurrence in patients with craniopharyngioma.
  • PATIENTS AND METHODS: All the patients with craniopharyngioma followed-up at the Departments of Endocrinology or Paediatrics in Oxford and treated or not with GH were studied retrospectively.
  • The remaining 32 (22 males/10 females) received GH for a mean period of 6.3 +/- 4.6 years (median 5.1, range 0.8-22); 21 started during childhood (13 of them continued after the achievement of final height with an adult dose) and 11 during adult life.
  • None of the nine patients with insufficient imaging data for inclusion in the statistical analyses [5 men/4 women, 3 treated with GH during childhood/6 during adult life, mean duration of GH therapy 2.9 +/- 2.4 years (median 1.8, range 0.4-7)] showed clinical features suggestive of recurrence during the period of GH replacement.
  • CONCLUSION Based on the data of the craniopharyngiomas database in Oxford, there is no evidence that GH replacement is associated with an increased risk of tumour recurrence.
  • [MeSH-major] Brain Neoplasms / pathology. Craniopharyngioma / pathology. Growth Hormone / therapeutic use. Hormone Replacement Therapy. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Proportional Hazards Models. Retrospective Studies. Risk Factors

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  • (PMID = 16649976.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-72-6 / Growth Hormone
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96. Floyd JR, Cmelak A, Russell P, Weaver KD: Endoscopic, image-guided, transnasal instillation of (32)P for recurrent infrachiasmatic cystic craniopharyngioma. Minim Invasive Neurosurg; 2009 Jun;52(3):137-40
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  • [Title] Endoscopic, image-guided, transnasal instillation of (32)P for recurrent infrachiasmatic cystic craniopharyngioma.
  • INTRODUCTION: The neurovascular and anatomic relationships surrounding craniopharyngiomas, and their tending to recur despite any method of primary treatment, has characterized this tumor as an exigent and frustrating clinical entity.
  • CASE REPORT: We present a case where the patient had previously experienced a transsphenoidal resection followed by a pterional, microsurgical resection of her craniopharyngioma at an outside hospital.
  • CONCLUSION: While intracystic adionucleotide therapies have been utilized for primary and secondary treatment of craniopharyngioma, to our knowledge, this is the first report of the delivery of this therapy by an endoscopic transsphenoidal route.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Endoscopy / methods. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Minimally Invasive Surgical Procedures / methods. Neurosurgical Procedures / methods. Phosphorus Radioisotopes. Radiotherapy. Treatment Outcome

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  • [Copyright] Copyright Georg Thieme Verlag KG Stuttgart. New York.
  • (PMID = 19650017.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Phosphorus Radioisotopes
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97. Kabil MS, Shahinian HK: Application of the supraorbital endoscopic approach to tumors of the anterior cranial base. J Craniofac Surg; 2005 Nov;16(6):1070-4; discussion 1075
MedlinePlus Health Information. consumer health - Endoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pathologies treated were meningiomas, craniopharyngiomas, pituitary adenomas with extrasellarextensions, and other variable supratentorial pathologies.
  • The use of endoscopy allowed thorough visualization of all critical structures at the paramedian skull base without the need for a bicoronal scalp flap, bifrontal osteotomies, or brain retraction.
  • [MeSH-minor] Adenoma / surgery. Adult. Aged. Arachnoid Cysts / surgery. Craniopharyngioma / surgery. Electrocoagulation. Female. Follow-Up Studies. Frontal Sinus / surgery. Humans. Male. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Minimally Invasive Surgical Procedures. Mucocele / surgery. Paranasal Sinus Diseases / surgery. Pituitary Neoplasms / surgery. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • (PMID = 16327556.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. de Luis DA, Reina C: [Clinical and biochemical characteristics of patients with pituitary disease]. An Med Interna; 2005 Aug;22(8):364-8
MedlinePlus Health Information. consumer health - Pituitary Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Características clínico bioquímicas de pacientes con patología hipofisaria.
  • Pituitary adenoma are unfrequent, however this pathology represent 10-12% of brain tumors.
  • MATERIAL AND METHODS: We study 58 patients with diagnosis of pituitary tumor, with regular follow-up in our Hospital, between 1999-2001.
  • The most frequent tumor was prolactinoma and non-functioning adenomas, amenorrhea was the most frequent symptom with the specialist physician (15%) and the general practice physician was the first step in diagnosis protocol.
  • Invasive lesions (craniopharyngiomas, germinomas and invasive adenomas) representing a 6.9%.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged

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  • (PMID = 16351487.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Pituitary Hormones
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99. Joseph V, Chacko AG: Suprabrow minicraniotomy for suprasellar tumours. Br J Neurosurg; 2005 Feb;19(1):33-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumours included one epidermoid cyst, 10 meningiomas, five craniopharyngiomas and two optico-chiasmatico-hypothalamic (OCHG) gliomas.
  • Both OCHGs were biopsied; one craniopharyngioma was totally excised, the remaining craniopharyngiomas and epidermoid cyst were subtotally excised.
  • The patient with a craniopharyngioma that had a radical excision died of hypothalamic dysfunction.
  • This basal approach through a small craniotomy provided good surgical access to suprasellar tumours with minimal brain retraction.
  • [MeSH-major] Central Nervous System Neoplasms / surgery. Craniotomy / methods
  • [MeSH-minor] Adolescent. Adult. Child. Craniopharyngioma / radiography. Craniopharyngioma / surgery. Female. Glioma / radiography. Glioma / surgery. Humans. Male. Meningioma / radiography. Meningioma / surgery. Middle Aged. Minimally Invasive Surgical Procedures / methods. Postoperative Complications. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 16147580.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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100. Hori T, Kawamata T, Amano K, Aihara Y, Ono M, Miki N: Anterior interhemispheric approach for 100 tumors in and around the anterior third ventricle. Neurosurgery; 2010 Mar;66(3 Suppl Operative):65-74
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: One hundred patients with 46 craniopharyngiomas, 12 hypothalamic gliomas, 12 meningiomas, 6 hypothalamic hamartomas, and 24 other lesions were operated on using an anterior interhemispheric approach with or without opening of the lamina terminalis.
  • This surgical approach involves no frontal sinus opening; a narrow (approximately 15-20 mm in width) access between the bridging veins, which is sufficient to remove the tumor totally; and sparing of the anterior communicating artery.
  • RESULTS: Total removal of the neoplasm was accomplished in 37 of 46 patients with craniopharyngiomas (80.4%), whereas subtotal resection was performed in hypothalamic gliomas.
  • No significant differences in pre- and postoperative hormonal disturbances were observed in 37 craniopharyngiomas and 10 hypothalamic gliomas.
  • CONCLUSION: The minimally invasive anterior interhemispheric approach, with or without opening of the lamina terminalis, is useful for removal of tumors in and around the anterior third ventricle, such as craniopharyngiomas and hypothalamic gliomas.
  • [MeSH-major] Brain Neoplasms / surgery. Hypothalamus / surgery. Neurosurgical Procedures / methods. Third Ventricle / surgery. Ventriculostomy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebrum / anatomy & histology. Cerebrum / surgery. Child. Child, Preschool. Craniopharyngioma / pathology. Craniopharyngioma / surgery. Female. Glioma / pathology. Glioma / surgery. Hamartoma / pathology. Hamartoma / surgery. Humans. Infant. Male. Meningioma / pathology. Meningioma / surgery. Middle Aged. Minimally Invasive Surgical Procedures / instrumentation. Minimally Invasive Surgical Procedures / methods. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Surgical Instruments / standards. Treatment Outcome. Young Adult

  • MedlinePlus Health Information. consumer health - Brain Tumors.
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  • (PMID = 20173574.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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