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1. Bauchet L, Rigau V, Mathieu-Daudé H, Fabbro-Peray P, Palenzuela G, Figarella-Branger D, Moritz J, Puget S, Bauchet F, Pallusseau L, Duffau H, Coubes P, Trétarre B, Labrousse F, Dhellemmes P, Société Française de Neurochirurgie Pédiatrique, Société Française de Neurochirurgie, Société Française de Neuropathologie, Association des Neuro-Oncologues d'Expression Française: Clinical epidemiology for childhood primary central nervous system tumors. J Neurooncol; 2009 Mar;92(1):87-98
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  • [Title] Clinical epidemiology for childhood primary central nervous system tumors.
  • This work was conducted by the French Brain Tumor Data Bank (FBTDB) and aims to prospectively record all primary central nervous system tumors (PCNST), in France, for which histological diagnosis is available.
  • The Tumor Registry from Herault was authorized to compile the data files with personal identifiers.
  • About 1,017 cases (533 boys and 484 girls) of newly diagnosed childhood PCNST have been recorded (gliomas: 52%, all other neuroepithelial tumors: 31%, craniopharyngioma: 5%, germ cell tumors, meningioma and neurinoma: approximately 3% each, all histological subtypes have been detailed).
  • Tumor resections were performed in 83.3%, and biopsies in 16.7%.
  • The distributions by histology, cryopreservation of the samples, age, sex, tumor site and surgery have been detailed.
  • The long term goals of the FBTDB are to create a national registry and a network to perform epidemiological studies, to implement clinical and basic research protocols, and to evaluate and harmonize the healthcare of children and adult patients affected by PCNST.
  • [MeSH-major] Central Nervous System Neoplasms / epidemiology. Registries
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. France / epidemiology. Humans. Infant. Infant, Newborn. Male

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  • (PMID = 19020806.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Aghakhani N; Ali Benali M; Alliez B; Amat D; Amlashi A; Arbez-Gindre F; Arbion F; Assaker R; Aubriot Lorton MH; Auque J; Autricque A; Auvigne I; Averous G; Baldet P; Bataille B; Bazin A; Beaurain J; Benezech J; Bergemer Fouquet A; Besson G; Beuvon F; Billotet C; Blond S; Boetto S; Boissonnet H; Bonyhay G; Bouillot P; Bourgeois P; Bouvier C; Brassier G; Broche C; Brunon J; Cabal P; Cahn V; Caire F; Calvet P; Cazals-Hatem D; Chapon F; Chazal J; Civit T; Colnat S; Colombat M; Comoy J; Couvelard A; Czorny A; Dam Hieu P; Daumas-Duport C; Dautheribes M; David P; Debono B; Delage Corre M; Delhaye M; Delisle MB; Delsol G; Derlon JM; Desenclos C; Desplat A; Devaux B; Di Rocco F; Diaz A; Diebold MD; Dorfmuller G; Dran G; Dufour T; Dumas B; Dumollard JM; Durand L; Duthel R; Eimer S; El Fertit H; Emery E; Espagno C; Esposito P; Etchandy MP; Eyremandi RP; Faillot T; Felix S; Fernandez C; Fesselet J; Fontaine D; Fournier D; François P; Froelich S; Fuentes JM; Fuentes S; Gadan R; Gaspard C; Gay G; Gigaud M; Gil Robles S; Godard J; Gontier MF; Goujon JM; Gray F; Grignon Y; Grisoli F; Guarnieri J; Guyotat J; Hallacq P; Hamlat A; Hayek G; Heitzmann A; Hennequin V; Huot JC; Irthum B; Jacquet G; Jan M; Jaubert F; Jouanneau E; Jouvet A; Justrabo E; Kalamarides M; Kehrli P; Kemeny JL; Keravel Y; Kerdraon R; Khalil T; Khouri K; Khouri S; Klein O; Kujas M; Lacroix C; Lagarrigue J; Langlois O; Lapierre F; Laquerriere A; Laurent MC; Le Gall F; Le Guerinel C; Le Houcq M; Lechapt E; Legars D; Lemaire JJ; Lena G; Lepeintre JF; Leriche B; Lescure JP; Levillain P; Liguoro D; Lioret E; Listrat A; Loiseau H; Lonjon M; Lopes M; Lot G; Louis E; Maheut-Lourmière J; Maillard A; Maitre F; Maitrot D; Majek-Zakine E; Mandonnet E; Manzo N; Marchal JC; Marie B; Maurage CA; Menei P; Mercier P; Mergey E; Metellus P; Michalak S; Michiels JF; Milinkevitch S; Mineo JF; Miquel C; Mireau E; Mohr M; Mokhtari K; Morandi X; Morar S; Moreau JJ; Moreno S; Mourier KL; Mottolese C; Nataf F; Neuville A; Nogues L; Noudel R; Nuti C; Page P; Paquis P; Parent M; Parker F; Pasqualini F; Patey M; Pelissou-Guyotat I; Peoc'h M; Peragut JC; Peruzzi P; Pierre-Kahn A; Pinelli C; Polivka M; Pommepuy I; Ponnelle T; Porhiel V; Proust F; Quintin-Roue I; Ragragui O; Rasendrarijao D; Raynaud P; Redondo A; Renjard L; Reyns N; Richard S; Richaud J; Riem T; Riffaud L; Ringenbach F; Robert G; Roche PH; Rodriguez MA; Roujeau T; Rousseaux P; Rousselet MC; Roux FE; Roux FX; Ruchoux MM; Sabatier J; Sabatier P; Saïkali S; Saint Andre JP; Saint Pierre G; Saint-Rose C; San Galli F; Sautreaux JL; Sawan B; Scavarda D; Segnarbieux F; Seigneuret E; Sindou M; Sorbara R; Sorin A; Stilhart B; Straub P; Taha S; Ternier JP; Tortel MC; Toussaint P; Touzet G; Tremoulet M; Trouillas J; Tubiana A; Uro-Coste E; Vandenbos F; Varlet P; Velut S; Vidal J; Viennet G; Vignaud JM; Vignes JR; Vinchon M; Vital A; Wager M; Weinbreck N; Zerah M
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2. Wisoff JH, Jane JA Jr, Selman W, Fahlbusch R: Introduction: Craniopharyngioma. Neurosurg Focus; 2010 Apr;28(4):1 p preceding E1
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  • [Title] Introduction: Craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adult. Child. Humans. Neurosurgical Procedures / methods. Pituitary Irradiation / methods. Risk Assessment

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  • (PMID = 20369435.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Introductory Journal Article
  • [Publication-country] United States
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3. Adler JR Jr, Gibbs IC, Puataweepong P, Chang SD: Visual field preservation after multisession cyberknife radiosurgery for perioptic lesions. Neurosurgery; 2006 Aug;59(2):244-54; discussion 244-54
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  • METHODS: Forty-nine consecutive patients with meningioma (n = 27), pituitary adenoma (n = 19), craniopharyngioma (n = 2), or mixed germ cell tumor (n = 1) situated within 2 mm of a "short segment" of the optic apparatus underwent multisession image-guided radiosurgery at Stanford University Medical Center.
  • CyberKnife radiosurgery was delivered in two to five sessions to an average tumor volume of 7.7 cm3 and a cumulative average marginal dose of 20.3 Gy.
  • In each instance, visual deterioration was accompanied by tumor progression that ultimately resulted in patient death.
  • However, one of these patients, who had a multiply recurrent adrenocorticotropic hormone-secreting pituitary adenoma, initially experienced early visual loss without significant tumor progression after both a previous course of radiotherapy and three separate sessions of radiosurgery.
  • After a mean magnetic resonance imaging follow-up period of 46 months, tumor volume was stable or smaller in all other cases.
  • CONCLUSION: Multisession radiosurgery resulted in high rates of tumor control and preservation of visual function in this group of perioptic tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Craniopharyngioma / diagnosis. Craniopharyngioma / physiopathology. Craniopharyngioma / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / diagnosis. Meningioma / physiopathology. Meningioma / surgery. Middle Aged. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / physiopathology. Pituitary Neoplasms / surgery. Preoperative Care / methods. Preoperative Care / standards. Radiation Dosage. Retrospective Studies. Survival Rate / trends. Tomography, X-Ray Computed. Treatment Outcome. Visual Pathways / injuries. Visual Pathways / physiopathology. Visual Pathways / radiation effects

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  • [ReprintIn] Neurosurgery. 2008 Feb;62 Suppl 2:733-43 [18596432.001]
  • (PMID = 16883165.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. Schittenhelm J, Psaras T, Meyermann R, Honegger J, Beschorner R: Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. Folia Neuropathol; 2010;48(2):75-80
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  • [Title] Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms.
  • While many neoplasms have been studied, to date, no data is available on CDX2 expression in craniopharyngiomas.
  • MATERIAL AND METHODS: We investigated CDX2 expression in 28 normal pituitary glands, 75 pituitary adenomas of varying hormonal activity (including 7 invasive adenomas and 7 atypical adenomas) and 23 craniopharyngiomas (17 adamantinous and 6 papillary) in tissue microarrays.
  • RESULTS: None of the pituitary adenomas, craniopharyngiomas and normal pituitary glands showed expression of CDX2.
  • CONCLUSIONS: There is no evidence for that CDX2 might play a role in tumourigenesis, invasive growth or tumour recurrence of pituitary adenomas or in tumourigenesis of craniopharyngiomas.

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  • (PMID = 20602288.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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5. Keita AD, Kane M, Guinto CO, Landoure G, Traore S, Karembe M, Toure M, Diallo AK, Fongoro S, Sidibe S, Traore M, Traore I: [Using CT to diagnose brain tumors at the Point G Hospital in Mali]. Mali Med; 2007;22(2):14-8
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  • [Title] [Using CT to diagnose brain tumors at the Point G Hospital in Mali].
  • [Transliterated title] Apports de la tomodensitometie dans la prise en charge des tumeurs cerebrales a l'Hopital du Point G (Mali).
  • The main tumors detected with CT scan include glyoma (.5 cases), craniopharyngioma (3 cases), adenoma (3 cases), medulloblastoma (3 cases), and metastasis (3 cases).
  • [MeSH-major] Brain / radiography. Brain Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Mali. Middle Aged. Young Adult

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  • (PMID = 19437825.001).
  • [ISSN] 0464-7874
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mali
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6. Klose M, Jonsson B, Abs R, Popovic V, Koltowska-Häggström M, Saller B, Feldt-Rasmussen U, Kourides I: From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum - a KIMS analysis. Eur J Endocrinol; 2009 Nov;161 Suppl 1:S75-83
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  • OBJECTIVE: To describe baseline clinical presentation, treatment effects and evolution of isolated GH deficiency (IGHD) to multiple pituitary hormone deficiency (MPHD) in adult-onset (AO) GHD.

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  • (PMID = 19684053.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pituitary Hormones; 12629-01-5 / Human Growth Hormone
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7. Zhou L, Li Q, Luo L, Xu J, Zhang Y, Chen T, Wei Y, You C: Radiological features of craniopharyngiomas located in the posterior fossa. J Neurol Sci; 2009 Dec 15;287(1-2):119-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiological features of craniopharyngiomas located in the posterior fossa.
  • BACKGROUND AND PURPOSE: Posterior fossa craniopharyngiomas (PFCP) constitute 1.6-4% of all craniopharyngiomas and have long been neglected.
  • Seven tumors were of retrochiasmatic origin and 5 of 7 were of retrostalk growth pattern with location in the ventral area of brain stem.
  • Total tumor removal was accomplished in 5 cases, subtotal removal and partial removal in 1 case respectively.
  • Tumor with cystic component arises from sellar region and then extends to posterior fossa, which should be strongly suspected as a PFCP.
  • [MeSH-major] Cranial Fossa, Posterior / pathology. Craniopharyngioma / pathology. Infratentorial Neoplasms / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Central Nervous System Cysts / etiology. Central Nervous System Cysts / pathology. Central Nervous System Cysts / radiography. Child. Cohort Studies. Craniotomy / methods. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Pituitary Gland / pathology. Pituitary Gland / radiography. Pituitary Gland / surgery. Sella Turcica / pathology. Sella Turcica / radiography. Sella Turcica / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19758604.001).
  • [ISSN] 1878-5883
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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8. Monteiro ML, Moura FC, Medeiros FA: Scanning laser polarimetry with enhanced corneal compensation for detection of axonal loss in band atrophy of the optic nerve. Am J Ophthalmol; 2008 Apr;145(4):747-754
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / pathology. Adolescent. Adult. Aged. Birefringence. Craniopharyngioma / pathology. Cross-Sectional Studies. Female. Humans. Lasers. Male. Middle Aged. Pituitary Neoplasms / pathology. Prospective Studies. ROC Curve. Reproducibility of Results. Vision Disorders / diagnosis. Visual Fields

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  • (PMID = 18241832.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Van Gompel JJ, Nippoldt TB, Higgins DM, Meyer FB: Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity. Neurosurg Focus; 2010 Apr;28(4):E3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity.
  • OBJECT: Obesity as a consequence of management of pediatric craniopharyngioma is a well-described phenomenon related to the degree of hypothalamic involvement.
  • However, weight change and obesity have not been analyzed in adult patients.
  • Therefore, the purpose of this study was 1) to evaluate the pattern of postoperative weight gain related to preoperative body mass index (BMI), 2) determine if postoperative weight gain is an issue in adult patients, and 3) develop an objective MR imaging grading system to predict risk of postoperative weight gain and obesity in adults treated for craniopharyngioma.
  • METHODS: The authors retrospectively screened 296 patients with known craniopharyngioma for the following inclusion criteria: pathologically confirmed craniopharyngioma, index surgery at the authors' institution, and operative weight and height recorded with at least 3 months of follow-up including body weight measurement.
  • Cases of craniopharyngiomas were compared with age- and sex-matched controls (pituitary adenoma patients) to evaluate the pattern and significance of perioperative weight changes.
  • Comparing craniopharyngioma patients (cases) to age- and sex-matched controls, the preoperative BMIs were similar (p = 0.93) between cases (mean 28.9 [95% CI 30.9-26.9]) and controls (mean 29.3 [95% CI 31.9-26.7]).
  • CONCLUSIONS: Postoperative weight gain in adult patients undergoing surgery for craniopharyngioma is a significant problem and correlates with hypothalamic involvement, as it does in pediatric patients.
  • [MeSH-major] Craniopharyngioma / surgery. Magnetic Resonance Imaging / statistics & numerical data. Obesity / diagnosis. Pituitary Neoplasms / surgery. Postoperative Complications / diagnosis
  • [MeSH-minor] Adolescent. Adult. Age Factors. Body Mass Index. Female. Follow-Up Studies. Humans. Hypophysectomy / methods. Hypothalamus / pathology. Hypothalamus / surgery. Male. Preoperative Care. Retrospective Studies. Risk Factors. Weight Gain


10. Buslei R, Kreutzer J, Hofmann B, Schmidt V, Siebzehnrübl F, Hahnen E, Eyupoglu IY, Fahlbusch R, Blümcke I: Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas. Acta Neuropathol; 2006 Mar;111(3):264-71
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  • We have investigated the CpG island methylation status of SOCS-1 in a cohort of pituitary adenomas (PA; n=57), craniopharyngiomas (CP; n=30) and normal pituitary tissue (NP; n=11) using methylation sensitive single-strand conformation polymorphism analysis (MS-SSCP) and direct sequencing.
  • [MeSH-minor] Adolescent. Adult. Aged. Craniopharyngioma / genetics. Craniopharyngioma / metabolism. DNA Methylation. DNA, Neoplasm / metabolism. Female. Gene Expression Regulation, Neoplastic. Humans. Janus Kinases / physiology. Male. Middle Aged. STAT Transcription Factors / physiology. Signal Transduction / physiology

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  • (PMID = 16421738.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / SOCS1 protein, human; 0 / STAT Transcription Factors; 0 / Suppressor of Cytokine Signaling Proteins; EC 2.7.10.2 / Janus Kinases
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11. Plotnick L, Rapaport R, Desrosiers P, Fuqua JS: Update from the GHMonitorSM observational registry in children treated with recombinant human growth hormone (Saizen). Pediatr Endocrinol Rev; 2009 Jan;6 Suppl 2:278-82
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  • Two serious adverse events related to Saizen (hospitalization for placement of right frontal ventriculostomy and right frontal craniotomy for transcallosal resection of a large recurrent craniopharyngioma and left slipped capitofemoral epiphysis that required pinning of the right hip) were reported in the period from August 2006 to August 2007.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Male. Pituitary Hormones / deficiency. Recombinant Proteins / adverse effects. Recombinant Proteins / therapeutic use. Registries. Young Adult

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  • (PMID = 19337182.001).
  • [ISSN] 1565-4753
  • [Journal-full-title] Pediatric endocrinology reviews : PER
  • [ISO-abbreviation] Pediatr Endocrinol Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Pituitary Hormones; 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone
  • [Number-of-references] 6
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12. Müller HL, Müller-Stöver S, Gebhardt U, Kolb R, Sörensen N, Handwerker G: Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients. J Pediatr Endocrinol Metab; 2006 Apr;19 Suppl 1:423-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients.
  • Prognosis in childhood craniopharyngioma survivors hinges upon late effects such as pituitary deficiency and obesity.
  • We analyzed the degree of daytime sleepiness in 115 childhood craniopharyngioma patients (47% obese) using the Epworth Sleepiness Scale (ESS).
  • Polysomnography (PSG) and Multiple Sleep Latency Tests (MSLT) were conducted with 10 obese patients presenting increased daytime sleepiness, with only two craniopharyngioma patients revealing a sleep related breathing disorder.
  • We speculate that secondary narcolepsy is an exacerbating condition of childhood craniopharyngioma obesity, supported by recent reports on orexin and narcolepsy which suggest hypothalamic failure in idiopathic narcolepsy.
  • [MeSH-major] Craniopharyngioma / complications. Narcolepsy / etiology. Obesity / complications. Pituitary Neoplasms / complications
  • [MeSH-minor] Adolescent. Adult. Body Mass Index. Central Nervous System Stimulants / therapeutic use. Child. Cohort Studies. Female. HLA Antigens / metabolism. Humans. Male. Polysomnography. Risk Factors. Sleep / physiology. Sleep Stages


13. Cavallo LM, Prevedello D, Esposito F, Laws ER Jr, Dusick JR, Messina A, Jane JA Jr, Kelly DF, Cappabianca P: The role of the endoscope in the transsphenoidal management of cystic lesions of the sellar region. Neurosurg Rev; 2008 Jan;31(1):55-64; discussion 64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cystic mass lesions within the sella turcica are common, and they include cystic pituitary adenomas, craniopharyngiomas, Rathke's cleft cysts, arachnoid cysts, and other entities.
  • The series consisted of 26 pituitary macroadenomas, 20 Rathke's cleft cysts, 18 craniopharyngiomas, 10 arachnoid cysts, one craniopharyngioma associated with an adrenocorticotropic hormone-secreting adenoma, and one chordoid glioma.
  • Its routine use during transsphenoidal surgery for such lesions is recommended to achieve maximal and safe tumor removal.
  • [MeSH-minor] Adenoma / surgery. Adult. Aged. Arachnoid Cysts / surgery. Central Nervous System Cysts / surgery. Craniopharyngioma / surgery. Female. Humans. Male. Middle Aged. Neurosurgical Procedures / instrumentation. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery. Sphenoid Sinus

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  • (PMID = 17922153.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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14. Tanaka Y, Takemae T, Kobayashi S, Sakai K, Miyahara T, Ishizaka S, Kodama K, Kobayashi T, Ichikawa Y, Tsutsumi K, Hongo K: [Clinical analysis of treatment and long-term outcome in 56 craniopharyngiomas]. No Shinkei Geka; 2007 Sep;35(9):887-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of treatment and long-term outcome in 56 craniopharyngiomas].
  • In order to improve QOL in patients with craniopharyngioma, retrospective analysis was performed to discover factors for influencing functional outcome and the best treatment strategy.
  • Subtotal tumor resection with prophylactic radiation was performed in 8 patients (Group D).
  • Tumor recurrence was noted in 19 patients and stereotactic radiation or 2nd operation was performed in 11 patients (Group B).
  • Factors leading to poor outcome included extrasellar origin, solid tumor, bad score before treatment, 2nd surgery for recurrence.
  • Maximum tumor removal should be attempted with functional preservation.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Treatment Outcome

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  • (PMID = 17867308.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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15. [Craniopharyngiomas in the adults]. Arkh Patol; 2005 Jul-Aug;67(4):41-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Craniopharyngiomas in the adults].
  • Craniopharyngiomas (CP) were studied morphologically (52 cases), immunohistochemically (6 cases) and molecular-genetically (5 cases) in patients aged 18-65 years.
  • [MeSH-major] Biomarkers, Tumor / analysis. Craniopharyngioma / diagnosis. Craniopharyngioma / mortality. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Mutation


16. Chargari C, Bauduceau O, Le Moulec S, Vedrine L, Ceccaldi B: [Craniopharyngioma]. Rev Prat; 2007 Oct 31;57(16):1756
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Craniopharyngioma].
  • [Transliterated title] Craniopharyngiome.
  • [MeSH-major] Craniopharyngioma / diagnosis. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 18092716.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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17. Yamada S, Fukuhara N, Oyama K, Takeshita A, Takeuchi Y, Ito J, Inoshita N: Surgical outcome in 90 patients with craniopharyngioma: an evaluation of transsphenoidal surgery. World Neurosurg; 2010 Aug-Sep;74(2-3):320-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcome in 90 patients with craniopharyngioma: an evaluation of transsphenoidal surgery.
  • OBJECTIVE: To analyze surgical outcomes in 90 patients with craniopharyngioma treated by standard transsphenoidal surgery (TSS) or extended transsphenoidal surgery (eTSS).
  • METHODS: From 1990-2008, 90 patients (64 adults and 26 children) underwent TSS for craniopharyngioma (34 subdiaphragmatic and 56 supradiaphragmatic).
  • RESULTS: Total tumor removal was achieved in 70 (77.8%) patients, subtotal removal was achieved in 17 (18.9%), and partial removal was achieved in 3 (3.3%).
  • Tumor recurrence was observed in seven (7.8%) patients during a mean follow-up period of 4.6 years.
  • CONCLUSIONS: Most craniopharyngiomas including the supradiaphragmatic type can be removed safely by TSS with a good outcome, although endocrine function frequently worsens after surgery.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery. Sphenoid Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Hormones / blood. Humans. Image Interpretation, Computer-Assisted. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Pituitary Gland / pathology. Postoperative Complications / mortality. Postoperative Complications / pathology. Tomography, X-Ray Computed. Treatment Outcome. Vision Disorders / etiology. Vision Tests. Vision, Ocular. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] World Neurosurg. 2010 Aug-Sep;74(2-3):256-8 [21492550.001]
  • [CommentIn] World Neurosurg. 2010 Aug-Sep;74(2-3):254-5 [21492549.001]
  • (PMID = 21492566.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hormones
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18. Bawden HN, Salisbury S, Eskes G, Morehouse R: Neuropsychological functioning following craniopharyngioma removal. J Clin Exp Neuropsychol; 2009 Jan;31(1):140-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuropsychological functioning following craniopharyngioma removal.
  • The neuropsychological functioning of patients who had undergone surgical removal of craniopharyngiomas was compared to that of an endocrine control group composed of patients with nontumor hypopituitarism, an obese control group, and a normal control group.
  • The craniopharyngioma group had lower Performance IQ than did the normal control group, but their Performance IQ was comparable to that of the hypopituitarism and obese control groups.
  • The craniopharyngioma patients did not differ in Verbal or Full Scale IQs from the remaining groups.
  • The group mean scores on the measures of intelligence and neuropsychological abilities for the craniopharyngioma patients were in the low-average to average range.
  • While craniopharyngioma patients can have significant morbidity including endocrine and visual deficits as well as obesity resulting from hyperphagia, neuropsychological deficits are not always present.
  • [MeSH-major] Craniopharyngioma / physiopathology. Neuropsychological Tests. Pituitary Neoplasms / physiopathology
  • [MeSH-minor] Analysis of Variance. Attention / physiology. Female. Humans. Hypopituitarism / physiopathology. Intelligence. Male. Memory. Obesity / physiopathology. Problem Solving / physiology. Young Adult

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  • (PMID = 18608690.001).
  • [ISSN] 1744-411X
  • [Journal-full-title] Journal of clinical and experimental neuropsychology
  • [ISO-abbreviation] J Clin Exp Neuropsychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Kawamata T, Amano K, Aihara Y, Kubo O, Hori T: Optimal treatment strategy for craniopharyngiomas based on long-term functional outcomes of recent and past treatment modalities. Neurosurg Rev; 2010 Jan;33(1):71-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optimal treatment strategy for craniopharyngiomas based on long-term functional outcomes of recent and past treatment modalities.
  • Although many authors have described treatment strategies for craniopharyngiomas, the optimal treatment of craniopharyngiomas remains controversial.
  • This study aimed to define an adequate surgical strategy for craniopharyngiomas by reviewing the long-term functional performance of patients treated by current and past treatment modalities.
  • There were 28 adult patients (14 males; median age, 44.4 years) and 27 children younger than 16 years of age (15 males; median age, 8.1 years).
  • Adequate primary treatment for craniopharyngiomas is important to avoid subsequent multiple treatments.
  • Craniopharyngiomas should be removed surgically as far as possible but without further deteriorating cognitive and visual functions, either as total resection or subtotal resection with a small remnant that is controllable by radiation therapy.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cognition Disorders / psychology. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Neurosurgical Procedures. Pituitary Function Tests. Postoperative Complications / pathology. Postoperative Complications / psychology. Prognosis. Radiosurgery. Tomography, X-Ray Computed. Treatment Outcome. Vision Tests. Young Adult

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  • (PMID = 19669813.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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20. Pinto AG, Namyslowski J, Pandya P: Severe thrombocytopenia due to hypersplenism successfully treated with partial splenic embolization in preoperative management. South Med J; 2005 Apr;98(4):481-3
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  • This report describes a 30-year-old male with a history of cirrhosis of the liver and hypersplenism who had a recurrence of craniopharyngioma.
  • A stereotactic injection of radioactive P32 into the tumor was planned but was thought not to be feasible because of the thrombocytopenia.
  • The thrombocytopenia responded favorably to partial splenic embolization, and the patient underwent successful stereotactic injection of radioactive P32 into the tumor.
  • [MeSH-minor] Adult. Craniopharyngioma / radiotherapy. Humans. Hypertension, Portal / complications. Liver Cirrhosis / complications. Male. Pituitary Neoplasms / radiotherapy

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  • (PMID = 15898530.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Binder G, Weber S, Ehrismann M, Zaiser N, Meisner C, Ranke MB, Maier L, Wudy SA, Hartmann MF, Heinrich U, Bettendorf M, Doerr HG, Pfaeffle RW, Keller E, South German Working Group for Pediatric Endocrinology: Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. J Clin Endocrinol Metab; 2009 Apr;94(4):1182-90
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  • [Title] Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial.
  • CONTEXT AND OBJECTIVE: The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown.
  • Exclusion criteria were cerebral radiation with more than 30 Gy, tumor remission less than 1 yr, amaurosis, hypothalamic obesity, psychiatric disorders, and unstable hormone medication.
  • INTERVENTION: Patients were randomized to placebo (n = 12) or 25 mg HPLC-purified DHEA/d (n = 11) orally for 12 months after stratification into a nontumor (n = 7) and a tumor group (n = 16).
  • RESULTS: In the placebo group, four patients dropped out because of recurrence of craniopharyngioma, manifestation of type 1 diabetes, and change of residence (n = 2); in the DHEA group, one patient dropped out because of recurrent anxiety attacks.
  • CONCLUSIONS: In adolescent girls with central adrenal insufficiency, daily replacement with 25 mg DHEA orally is beneficial: atrichia pubis vanishes, and psychological well-being improves significantly.
  • [MeSH-minor] Adolescent. Adult. Blood Pressure / drug effects. Blood Pressure / physiology. Brain Neoplasms / epidemiology. Double-Blind Method. Female. Humans. Hydrocortisone / therapeutic use. Obesity / epidemiology. Young Adult

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  • (PMID = 19126625.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 459AG36T1B / Dehydroepiandrosterone; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
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22. Wang SY, Zhu L, Li SM, Lin L, Zheng SX, Wu YF, Zhu XZ: [Sinonasal teratocarcinosarcoma: a clinical, radiologic and pathologic study of 5 cases]. Zhonghua Bing Li Xue Za Zhi; 2007 Aug;36(8):534-8
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  • Histologically, the tumor showed a heterogeneous admixture of components from the 3 germ cell layers, exhibiting various degrees of maturation.
  • The initial biopsy diagnosis included capillary hemangioma, olfactory neuroblastoma, craniopharyngioma and malignant mixed tumor.
  • CONCLUSIONS: Sinonasal teratocarcinosarcoma is a rare and highly malignant tumor occurring in sinonasal tract.
  • It manifests mainly in adult males and is characterized by a complex admixture of teratomatous and carcinosarcomatous components.
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Keratins / metabolism. Lymphatic Metastasis. Male. Mucin-1 / metabolism. Neck Dissection. Neoplasm Recurrence, Local

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  • (PMID = 17980101.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucin-1; 68238-35-7 / Keratins
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23. Stamm AC, Vellutini E, Harvey RJ, Nogeira JF Jr, Herman DR: Endoscopic transnasal craniotomy and the resection of craniopharyngioma. Laryngoscope; 2008 Jul;118(7):1142-8
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  • [Title] Endoscopic transnasal craniotomy and the resection of craniopharyngioma.
  • OBJECTIVES/HYPOTHESIS: To describe the utility of a large transnasal craniotomy and its reconstruction in the surgical management of patients with craniopharyngioma.
  • Patient characteristics (age, sex, follow-up), tumor factors (size, position extension, previous surgery), type of repair (pedicled mucosal flaps, free mucosal grafts), and outcomes (visual, endocrine, and surgical morbidity) were defined and sought in patients who had an entirely endoscopic resection of extensive craniopharyngioma (defined as requiring removal of the planum sphenoidale in addition to sella exposure in the approach).
  • RESULTS: Seven patients had an entirely endoscopic resection of extensive craniopharyngioma during the study period.
  • Mean tumor size was 3.2 cm (standard deviation +/- 2.0).
  • CONCLUSIONS: The endoscopic management of large craniopharyngioma emphasizes recent advancements in endoscopic skull base surgery.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Endoscopy / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Cohort Studies. Female. Follow-Up Studies. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / radiography. Postoperative Complications / surgery. Reoperation. Retrospective Studies. Skull Base / surgery. Sphenoid Sinus / radiography. Sphenoid Sinus / surgery. Tomography, X-Ray Computed. Treatment Outcome


24. Ragel BT, Bishop FS, Couldwell WT: Recurrent infrasellar clival craniopharyngioma. Acta Neurochir (Wien); 2007;149(7):729-30; discussion 730
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  • [Title] Recurrent infrasellar clival craniopharyngioma.
  • The patient is a 44-year-old man who underwent resection of a posterior nasopharynx tumor 12 years earlier via left lateral rhinotomy approach.
  • The final pathological analysis indicated the tumor was a craniopharyngioma, and the patient subsequently underwent focal radiation.
  • Magnetic resonance imaging revealed a clival mass, separate from the sella turcica, with imaging characteristics concerning for chordoma or primary bone tumor (Fig. 1).
  • The final pathological results indicated the tumor was adamantinomatous craniopharyngioma.
  • [MeSH-major] Cranial Fossa, Posterior / pathology. Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Nasopharynx / pathology. Nasopharynx / physiopathology. Nasopharynx / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Pituitary Gland / pathology. Radiotherapy. Sella Turcica / pathology

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  • (PMID = 17533510.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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25. Kitano M, Taneda M: Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach. Surg Neurol; 2009 Mar;71(3):290-8, discussion 298
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  • [Title] Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic trans-lamina terminalis approach.
  • To evaluate the capability of this approach for removal of suprasellar craniopharyngiomas, surgical outcomes were retrospectively analyzed.
  • METHODS: During a 9-year period, 20 consecutive patients with suprasellar craniopharyngioma underwent transsphenoidal tumor resection.
  • No patient had a purely intrasellar tumor, 9 had prechiasmatic tumors, 9 had retrochiasmatic tumors, and 2 had purely intraventricular tumors.
  • CONCLUSIONS: Reasonable surgical results in this study suggest that the extended transsphenoidal approach is safe and effective for removal of craniopharyngiomas.
  • Although preservation of the pituitary stalk can be achieved in a high percentage of patients, postoperative endocrinopathy still remains as a significant problem after radical removal of the craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / surgery. Neurosurgical Procedures / methods. Optic Chiasm. Pituitary Neoplasms / surgery. Sella Turcica
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pituitary Gland / surgery. Postoperative Complications. Retrospective Studies. Sphenoid Bone / surgery. Young Adult

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  • (PMID = 18291485.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Hori T, Kawamata T, Aihara Y, Amano K, Kubo O: [Minimally invasive anterior interhemispheric lamina terminalis approach for craniopharyngiomas. Anatomical, hormonal, and neuropsychological considerations]. No Shinkei Geka; 2007 Nov;35(11):1067-77
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  • [Title] [Minimally invasive anterior interhemispheric lamina terminalis approach for craniopharyngiomas. Anatomical, hormonal, and neuropsychological considerations].
  • [MeSH-major] Craniopharyngioma / surgery. Hypophysectomy / methods. Minimally Invasive Surgical Procedures. Neuropsychological Tests. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adrenocorticotropic Hormone / blood. Adult. Aged. Female. Humans. Hydrocortisone / blood. Male. Memory Disorders / etiology. Middle Aged. Pituitary Gland / anatomy & histology. Postoperative Complications. Third Ventricle / anatomy & histology

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  • (PMID = 18044224.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
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27. Ulfarsson E, Karström A, Yin S, Girnita A, Vasilcanu D, Thoren M, Kratz G, Hillman J, Axelson M, Larsson O, Girnita L: Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. Clin Cancer Res; 2005 Jul 1;11(13):4674-80
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  • [Title] Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.
  • Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children.
  • Together, these circumstances raise the question whether IGF-IR may be involved in craniopharyngioma growth.
  • To address this issue, we analyzed phenotypically well-characterized primary low-passage craniopharyngioma cell lines from nine different patients for IGF-IR expression and IGF-I dependency.
  • Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology. Receptor, IGF Type 1 / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Cell Proliferation / drug effects. Child. Dose-Response Relationship, Drug. Humans. Immunohistochemistry. Inhibitory Concentration 50. Insulin-Like Growth Factor I / pharmacology. Middle Aged. Phosphorylation / drug effects. Podophyllotoxin / analogs & derivatives. Podophyllotoxin / pharmacology. Tumor Cells, Cultured

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  • (PMID = 16000560.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0F35AOI227 / picropodophyllin; 67763-96-6 / Insulin-Like Growth Factor I; EC 2.7.10.1 / Receptor, IGF Type 1; L36H50F353 / Podophyllotoxin
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28. Floyd JR, Cmelak A, Russell P, Weaver KD: Endoscopic, image-guided, transnasal instillation of (32)P for recurrent infrachiasmatic cystic craniopharyngioma. Minim Invasive Neurosurg; 2009 Jun;52(3):137-40
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  • [Title] Endoscopic, image-guided, transnasal instillation of (32)P for recurrent infrachiasmatic cystic craniopharyngioma.
  • INTRODUCTION: The neurovascular and anatomic relationships surrounding craniopharyngiomas, and their tending to recur despite any method of primary treatment, has characterized this tumor as an exigent and frustrating clinical entity.
  • CASE REPORT: We present a case where the patient had previously experienced a transsphenoidal resection followed by a pterional, microsurgical resection of her craniopharyngioma at an outside hospital.
  • CONCLUSION: While intracystic adionucleotide therapies have been utilized for primary and secondary treatment of craniopharyngioma, to our knowledge, this is the first report of the delivery of this therapy by an endoscopic transsphenoidal route.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Endoscopy / methods. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Pituitary Neoplasms / radiotherapy. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Minimally Invasive Surgical Procedures / methods. Neurosurgical Procedures / methods. Phosphorus Radioisotopes. Radiotherapy. Treatment Outcome

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  • [Copyright] Copyright Georg Thieme Verlag KG Stuttgart. New York.
  • (PMID = 19650017.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Phosphorus Radioisotopes
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29. Pettorini BL, Frassanito P, Caldarelli M, Tamburrini G, Massimi L, Di Rocco C: Molecular pathogenesis of craniopharyngioma: switching from a surgical approach to a biological one. Neurosurg Focus; 2010 Apr;28(4):E1
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  • [Title] Molecular pathogenesis of craniopharyngioma: switching from a surgical approach to a biological one.
  • Craniopharyngioma has long been considered a benign tumor because of its pathological aspect.
  • This primordial view of craniopharyngioma fit with the primitive treatment attempts based on blind resection of the tumor each time it recurred.
  • Nowadays, craniopharyngioma must be considered a complex molecular disease, and a detailed explanation of the mechanisms underlying its aggressive biological and clinical behavior, despite some benign pathological features, would be the first step toward defining the best management of craniopharyngioma.
  • Indeed, advances in the knowledge of the molecular mechanisms at the base of craniopharyngioma oncogenesis will lead to comprehension of the critical checkpoints involved in neoplastic transformation.
  • In this paper the authors reveal state-of-the-art comprehension of the molecular biology of craniopharyngioma and the consequent therapeutic implications.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adult. Child. Humans. Molecular Biology / methods. Neoplastic Processes

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  • (PMID = 20367353.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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30. Marcus KJ, Goumnerova L, Billett AL, Lavally B, Scott RM, Bishop K, Xu R, Young Poussaint T, Kieran M, Kooy H, Pomeroy SL, Tarbell NJ: Stereotactic radiotherapy for localized low-grade gliomas in children: final results of a prospective trial. Int J Radiat Oncol Biol Phys; 2005 Feb 1;61(2):374-9
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  • PURPOSE: To evaluate the efficacy of stereotactic radiotherapy (SRT) for small, localized, pediatric brain tumors and to determine the patterns of failure.
  • Of the 81 patients, 50 had low-grade astrocytoma, 23 had residual or recurrent craniopharyngioma, 4 had posterior fossa ependymoma, and 4 had other histologic types.
  • All patients underwent biopsy for diagnosis, with the exception of patients with neurofibromatosis and radiographic evidence of an optic system tumor.
  • The target volume generally included the preoperative tumor plus a 2-mm margin for the planning target volume.
  • Five patients, all with optic system/hypothalamic primary tumors, developed central nervous system dissemination 1.0-7.4 years after SRT.
  • One patient developed a presumed radiation-induced primitive neuroectodermal tumor 6 years after initial treatment.
  • Six patients died, three of dissemination, two of progression to higher grade tumors, and one of a secondary radiation-induced tumor.
  • All 6 cases of local progression were within the primary tumor bed at the time of progression and had received the full prescription dose.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Confidence Intervals. Disease Progression. Disease-Free Survival. Female. Humans. Male. Neoplasm Recurrence, Local / drug therapy. Prospective Studies. Radiotherapy Dosage

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  • (PMID = 15667955.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Bonneville F, Cattin F, Marsot-Dupuch K, Dormont D, Bonneville JF, Chiras J: T1 signal hyperintensity in the sellar region: spectrum of findings. Radiographics; 2006 Jan-Feb;26(1):93-113
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  • Pathologic variations in T1 signal hyperintensity may be related to clotting of blood (in hemorrhagic pituitary adenoma, pituitary apoplexy, Sheehan syndrome, or thrombosed aneurysm) or the presence of a high concentration of protein (Rathke cleft cyst, craniopharyngioma, or mucocele), fat (lipoma, dermoid cyst, lipomatous meningioma), calcification (craniopharyngioma, chondroma, chordoma), or a paramagnetic substance (manganese, melanin).
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Infant, Newborn. Male. Middle Aged

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  • [Copyright] (c) RSNA, 2006.
  • (PMID = 16418246.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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32. Bikmaz K, Guerrero CA, Dammers R, Krisht AF, Husain MM: Ectopic recurrence of craniopharyngiomas: case report. Neurosurgery; 2009 Feb;64(2):E382-3; discussion E383
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  • [Title] Ectopic recurrence of craniopharyngiomas: case report.
  • OBJECTIVE: Craniopharyngiomas are benign tumors that originate from squamous cell rests of the embryonal hypophyseal-pharyngeal duct located along the pituitary stalk.
  • After their surgical resection, recurrence usually occurs in the region of the original tumor bed.
  • Ectopic recurrence of craniopharyngiomas is extremely rare.
  • We present 3 examples of ectopic recurrences of craniopharyngiomas.
  • CLINICAL PRESENTATION: The first patient was a 52-year-old woman with a history of resected suprasellar craniopharyngioma presenting 15 years later with a history of balance problems and new onset of double vision.
  • Her magnetic resonance imaging scan revealed a tumor in the prepontine cistern.
  • The second patient was a 41-year-old man with a history of a resected suprasellar craniopharyngioma presenting 9 years later with headache, dizziness, and disequilibrium.
  • The third patient was a 24-year-old man with a history of suprasellar craniopharyngioma resection, followed by conventional radiotherapy 12 years before his recent presentation with headache, numbness of the right side of his face, and increased drowsiness.
  • INTERVENTION: The first patient underwent operation via a petrosal approach with subtotal resection of the tumor and decompression of the brainstem; this patient had an uneventful postoperative course.
  • The tumor in the second patient was surgically resected through a pterional craniotomy, with an uneventful postoperative course.
  • The third patient's right-sided cerebellopontine angle lesion was microsurgically resected, and the patient was given a single-dose gamma knife for the left-side and residual small right-side tumor.
  • The histological diagnosis of all 3 lesions was craniopharyngioma.
  • CONCLUSION: Although ectopic recurrence of a craniopharyngioma is very rare, it should always be considered in the differential diagnosis of what appears to be a new tumor in a patient with a history of previously resected craniopharyngiomas.
  • Long-term follow-up of patients with resected craniopharyngioma is very important.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19190442.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Fahlbusch R, Hofmann BM: Surgical management of giant craniopharyngiomas. Acta Neurochir (Wien); 2008 Dec;150(12):1213-26
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  • [Title] Surgical management of giant craniopharyngiomas.
  • INTRODUCTION: Multimodal treatment in the management of giant craniopharyngiomas (>4 cm in diameter) is necessary to obtain optimal results, and includes conservative or palliative treatment and "aggressive" removal.
  • MATERIALS AND METHODS: Between January 1996 and January 2005 16 patients were diagnosed with giant craniopharyngiomas.
  • If hypothalamic disturbances are absent or improving due to pre-treatment (medical therapy, symptomatic surgery), giant craniopharyngiomas can be surgically removed in more than two of three patients with low morbidity and only moderate deterioration of endocrine function.
  • [MeSH-major] Craniopharyngioma / surgery. Microsurgery / methods. Neurosurgical Procedures / methods. Pituitary Gland / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Central Nervous System Cysts / etiology. Central Nervous System Cysts / pathology. Central Nervous System Cysts / surgery. Child. Clinical Protocols. Female. Hormone Replacement Therapy / methods. Humans. Hypothalamo-Hypophyseal System / physiopathology. Hypothalamo-Hypophyseal System / secretion. Hypothalamo-Hypophyseal System / surgery. Male. Middle Aged. Pituitary Hormones / blood. Pituitary Hormones / secretion. Preoperative Care / methods. Prospective Studies. Stereotaxic Techniques. Treatment Outcome

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  • (PMID = 19002375.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Pituitary Hormones
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34. Hitier M, Hibon R, Candelier G, Guarnieri J, Moreau S, Babin E: The uses of computer-assisted surgical navigation in trans-nasal pituitary gland surgery. Rev Laryngol Otol Rhinol (Bord); 2009;130(3):151-7
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  • PATIENTS AND METHODS: Twenty cases of transnasal pituitary gland surgery using a computer-assisted navigation system, carried out between 2002 and 2004, were retrospectively studied.
  • The pituitary tumours included 18 macroadenomas, a microadenoma and a craniopharyngioma.
  • The computer-assisted system used was the Digipointeur (Collin ORL) based on a system of spatial localization in electromagnetic fields.
  • CONCLUSION: In our experience, the use of a computer-assisted system in transseptal pituitary surgery gives reliable millimetric surgical precision in the localization of vital internal anatomical structures, optimizes surgical resection and increases levels of safety.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Nose. Retrospective Studies

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  • (PMID = 20345070.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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35. Dekkers OM, Biermasz NR, Smit JW, Groot LE, Roelfsema F, Romijn JA, Pereira AM: Quality of life in treated adult craniopharyngioma patients. Eur J Endocrinol; 2006 Mar;154(3):483-9
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  • [Title] Quality of life in treated adult craniopharyngioma patients.
  • A reduced QoL has been reported in childhood-onset craniopharyngioma; however, reports of QoL in adult craniopharyngioma patients are scarce.
  • In the present study, we assessed QoL in adult patients successfully treated for craniopharyngioma in our centre.
  • METHODS: In this study, we assessed QoL in 29 adult patients in remission during long-term follow-up after treatment for craniopharyngioma.
  • CONCLUSION: Adult patients treated for craniopharyngioma show persistent impairment in QoL, especially in the physical subscales.

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  • (PMID = 16498063.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Cao J, Lin JP, Yang LX, Chen K, Huang ZS: Expression of aberrant beta-catenin and impaired p63 in craniopharyngiomas. Br J Neurosurg; 2010 Jun;24(3):249-56
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  • [Title] Expression of aberrant beta-catenin and impaired p63 in craniopharyngiomas.
  • Craniopharyngiomas are rare, histologically benign, non-neuroepithelial epithelial tumors arising from the sellar region, the molecular pathogenesis of CPs is yet not understood.
  • The aim of the present study was to assess expression of aberrant beta-catenin and impaired p63 in 66 craniopharyngiomas included 51 adamantinomatous craniopharyngiomas and 15 squamous papillary craniopharyngiomas.
  • On immunohistochemistry, 47 out of 51 adamantinomatous craniopharyngiomas, but not squamous papillary craniopharyngiomas, showed strong nuclear/cytoplasmic expression for beta-catenin predominantly in compactly cohesive epithelial cells within the whorl-like arrays where ki-67 was almost absent and rarely in palisaded cells where ki-67 was mainly present.
  • P63 overexpression was observed in 45 out of 51 adamantinomatous craniopharyngiomas and 14 out of 15 squamous papillary craniopharyngiomas.
  • P63 stained not only in the nuclei of basal layer cells but also within the whorl-like arrays in adamantinomatous craniopharyngiomas and uniformly in squamous papillary craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / metabolism. Membrane Proteins / metabolism. Pituitary Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA-Binding Proteins / metabolism. Female. Humans. Immunohistochemistry. Infant. Ki-67 Antigen / metabolism. Male. Middle Aged. RNA, Messenger / metabolism. Trans-Activators / metabolism. Transcription Factors. Tumor Suppressor Proteins / metabolism. Young Adult

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  • (PMID = 20128632.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / beta Catenin
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37. Burghaus S, Hölsken A, Buchfelder M, Fahlbusch R, Riederer BM, Hans V, Blümcke I, Buslei R: A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch; 2010 Mar;456(3):287-300
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  • [Title] A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.
  • Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants.
  • Both subtypes are classified according to the World Health Organization grade I, but their irregular digitate brain infiltration makes any complete surgical resection difficult to obtain.
  • Herein, we characterized the cellular interface between the tumor and the surrounding brain tissue in 48 CP (41 adaCP and seven papCP) compared to non-neuroepithelial tumors, i.e., 12 cavernous hemangiomas, 10 meningiomas, and 14 metastases using antibodies directed against glial fibrillary acid protein (GFAP), vimentin, nestin, microtubule-associated protein 2 (MAP2) splice variants, and tenascin-C.
  • Furthermore, the outer tumor cell layer of adaCP showed a distinct expression of MAP2, a novel finding helpful in the differential diagnosis of epithelial tumors in the sellar region.
  • Our data support the hypothesis that adaCP, unlike other non-neuroepithelial tumors of the central nervous system, create a tumor-specific cellular environment at the tumor-brain junction.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Brain / metabolism. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Nerve Tissue Proteins / metabolism. Nestin. Tenascin / metabolism. Vimentin / metabolism

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  • (PMID = 20069432.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Tenascin; 0 / Vimentin
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38. Zantut-Wittmann DE, Garmes HM, Panzan AD, Lima Mde O, Baptista MT: Severe rhabdomyolysis due to adipsic hypernatremia after craniopharyngioma surgery. Arq Bras Endocrinol Metabol; 2007 Oct;51(7):1175-9
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  • [Title] Severe rhabdomyolysis due to adipsic hypernatremia after craniopharyngioma surgery.
  • The association of diabetes insipidus and adipsia after craniopharyngioma surgery has high morbidity.
  • CASE REPORT: This is the first report of a diabetic patient with craniopharyngioma who developed diabetes insipidus and adipsia after surgery, evolving with severe hypernatremia that caused considerable rhabdomyolysis.
  • [MeSH-major] Craniopharyngioma / surgery. Diabetes Insipidus / etiology. Hypernatremia / etiology. Pituitary Neoplasms / surgery. Rhabdomyolysis / etiology
  • [MeSH-minor] Administration, Intranasal. Adult. Creatine Kinase / blood. Dehydration. Drinking. Humans. Male. Postoperative Complications / therapy. Thirst


39. Fatemi N, Dusick JR, de Paiva Neto MA, Malkasian D, Kelly DF: Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas. Neurosurgery; 2009 May;64(5 Suppl 2):269-84; discussion 284-6
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  • [Title] Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas.
  • OBJECTIVE: Endonasal and supraorbital "eyebrow" craniotomies are increasingly being used to remove craniopharyngiomas and tuberculum sellae meningiomas.
  • METHODS: All consecutive patients who had endonasal or supraorbital removal of a craniopharyngioma or tuberculum sellae meningioma were analyzed.
  • RESULTS: Of 43 patients, 22 had a craniopharyngioma (18 endonasal, 4 supraorbital), and 21 had a meningioma (12 endonasal, 7 supraorbital, 2 both routes); 33% had prior surgery.
  • Craniopharyngiomas were primarily retrochiasmal in location in 78% of endonasal cases versus 25% of supraorbital cases (P = 0.08).
  • Of patients having first-time surgery for a craniopharyngioma (n = 14) or meningioma (n = 15), total/near total removal was achieved in 83% and 80% of patients by the endonasal route and in 50% and 80% of patients by the supraorbital route, respectively.
  • CONCLUSION: The endonasal route is preferred for removal of most retrochiasmal craniopharyngiomas, whereas the supraorbital route is recommended for meningiomas larger than 30 to 35 mm or with growth beyond the supraclinoid carotid arteries.
  • For smaller midline tumors, either approach can be used, depending on surgeon experience and tumor anatomy.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Meningeal Neoplasms / surgery. Meningioma / surgery. Pituitary Neoplasms / surgery. Sella Turcica / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Endoscopy / methods. Female. Frontal Bone / anatomy & histology. Frontal Bone / surgery. Humans. Intraoperative Complications / prevention & control. Male. Middle Aged. Nasal Cavity / anatomy & histology. Nasal Cavity / surgery. Neurosurgical Procedures / instrumentation. Neurosurgical Procedures / methods. Orbit / anatomy & histology. Orbit / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19287324.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Shkarubo AN, Serova NK, Tropinskaia OF, Shishkina LV, Pronin IN: [Chiasmatic cavernoma]. Zh Vopr Neirokhir Im N N Burdenko; 2005 Apr-Jun;(2):20-1; discussion 21-2
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  • The cause of chiasmatic apoplexy may be also hemorrhage into the tumor--chiasmatic glioma of blood penetration into the chiasma in pituitary apoplexy.
  • In addition to acute visual disorders suggesting the involvement of the left optic nerve, chiasma, and left visual pathway, 23-year-old patient had endocrine disorders as polyuria, polydipsia, which first suggests craniopharyngioma and glioma of the chiasma.
  • [MeSH-minor] Adult. Diagnostic Techniques, Ophthalmological. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Ophthalmologic Surgical Procedures. Optic Chiasm / pathology. Stroke / etiology. Tomography, X-Ray Computed / methods

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  • (PMID = 16078630.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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41. Kobayashi T: Long-term results of gamma knife radiosurgery for 100 consecutive cases of craniopharyngioma and a treatment strategy. Prog Neurol Surg; 2009;22:63-76
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  • [Title] Long-term results of gamma knife radiosurgery for 100 consecutive cases of craniopharyngioma and a treatment strategy.
  • A new treatment strategy using the gamma knife is proposed, based on evaluation of long-term results of gamma knife radiosurgery for residual or recurrent craniopharyngioma after microsurgery.
  • The mean volume of tumor was 3.5 ml.
  • Final overall results: complete response 19.4%, partial response 67.4%, tumor control rate 79.6% and progression rate 20.4%.
  • Age (for adults) and nature of tumor (cystic or mixed) were statistically significantly favorable and unfavorable prognostic factors, respectively.
  • The strategy is for a small tumor between the retrochiasm and anterior stalk to be treated by gamma knife radiotherapy with 10-12 Gy, allowing cure without neuroendocrine deficits.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Middle Aged. Postoperative Complications. Prognosis. Treatment Outcome. Young Adult

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  • (PMID = 18948720.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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42. Luo S, Pan J, Qi ST, Fang LX, Fan J, Liu BG: [Analysis of the factors contributing to diabetes insipidus after surgeries for craniopharyngiomas]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Mar;29(3):544-7
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  • [Title] [Analysis of the factors contributing to diabetes insipidus after surgeries for craniopharyngiomas].
  • OBJECTIVE: To analyze the factors contributing to the occurrence of diabetes insipidus after operations for craniopharyngiomas.
  • METHODS: A total of 121 cases of diabetes insipidus following surgeries for craniopharyngiomas were retrospectively analyzed and the factors associated with postoperative diabetes insipidus were analyzed.
  • The occurrence of early postoperative diabetes insipidus showed a significant relation to the classification and calcification of the craniopharyngioma.
  • Late postoperative diabetes insipidus was closely correlated to such factors as age, classification of craniopharyngioma, and intraoperative treatment of the pituitary stalk, but not to the scope of tumor resection or tumor calcification.
  • CONCLUSIONS: Postoperative diabetes insipidus following surgeries for craniopharyngiomas is closely related to the tumor classification, calcification and pituitary stalk protection.
  • [MeSH-major] Craniopharyngioma / surgery. Diabetes Insipidus / etiology. Pituitary Neoplasms / surgery. Postoperative Complications / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. China / epidemiology. Female. Humans. Incidence. Infant. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Regression Analysis. Retrospective Studies. Sella Turcica. Young Adult


43. Kitthaweesin K, Ployprasith C: Ocular manifestations of suprasellar tumors. J Med Assoc Thai; 2008 May;91(5):711-5
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  • MATERIAL AND METHOD: Medical records of 69 patients with a diagnosis of suprasellar tumor at Srinagarind Hospital between January 1995 and December 2005 were retrospectively reviewed.
  • The respective definite diagnosis were pituitary adenoma, suprasellar meningioma, and craniopharyngioma in 33 (48%), 19 (28%), and 17 (25%) patients.
  • CONCLUSION: Pituitary adenoma was the most frequent suprasellar tumor and visual loss was the most common ocular presentation.
  • [MeSH-major] Craniopharyngioma / pathology. Eye Diseases / etiology. Meningioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Retrospective Studies. Vision Disorders / etiology. Visual Acuity

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  • (PMID = 18672637.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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44. Kawamata T, Kubo O, Hori T: Histological findings at the boundary of craniopharyngiomas. Brain Tumor Pathol; 2005;22(2):75-8
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  • [Title] Histological findings at the boundary of craniopharyngiomas.
  • Although a craniopharyngioma is grossly well circumscribed, microscopically the borders are frequently irregular and may be associated with gliosis in the adjacent brain tissue.
  • In the current study, we investigated the histology of the interface between craniopharyngiomas and surrounding normal structures such as the hypothalamus and pituitary gland.
  • Histologically, we classified the findings at the boundary of craniopharyngiomas into three types.
  • In type 1, a relatively thick capsule-like tissue was identified at the boundary between the craniopharyngioma and surrounding normal structure composed of tumor cells and inflammatory changes.
  • In type 2, a craniopharyngioma had a relatively clear cleavage between the surrounding gliosis.
  • In type 3, the boundary had some interdigitation of the tumor in the surrounding gliotic layer adjacent to the craniopharyngioma.
  • In types 1 and 3, surgeons may fail to accomplish complete resection of the tumor.
  • These histological features may result in recurrence of craniopharyngioma even after gross total resection.
  • [MeSH-major] Craniopharyngioma / ultrastructure. Hypothalamus / ultrastructure. Pituitary Gland / ultrastructure. Pituitary Neoplasms / ultrastructure
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Stem / ultrastructure. Child. Child, Preschool. Female. Gliosis / etiology. Gliosis / pathology. Humans. Infant. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Visual Pathways / ultrastructure. Young Adult

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  • (PMID = 18095108.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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45. Frank G, Pasquini E, Doglietto F, Mazzatenta D, Sciarretta V, Farneti G, Calbucci F: The endoscopic extended transsphenoidal approach for craniopharyngiomas. Neurosurgery; 2006 Jul;59(1 Suppl 1):ONS75-83; discussion ONS75-83
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  • [Title] The endoscopic extended transsphenoidal approach for craniopharyngiomas.
  • The authors present their experience with this technique in 10 patients with craniopharyngiomas.
  • From November 1998 through May 2005, four males and six females with a craniopharyngioma, either purely supradiaphragmatic (six patients) or with a significant suprasellar component (four patients), were treated.
  • Further studies are required to better define the exact location of the tumor with respect to the arachnoidal plane, the extra-arachnoidal craniopharyngioma being the most suitable for a radical removal using a transsphenoidal supradiaphragmatic approach.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopy / methods. Neurosurgical Procedures / instrumentation. Pituitary Neoplasms / surgery. Sella Turcica / surgery. Sphenoid Sinus / surgery
  • [MeSH-minor] Adult. Cerebrospinal Fluid Rhinorrhea / etiology. Cerebrospinal Fluid Rhinorrhea / physiopathology. Child. Diabetes Insipidus, Neurogenic / etiology. Diabetes Insipidus, Neurogenic / physiopathology. Endocrine System Diseases / etiology. Endocrine System Diseases / physiopathology. Female. Follow-Up Studies. Humans. Hypothalamo-Hypophyseal System / physiopathology. Male. Middle Aged. Obesity / etiology. Obesity / physiopathology. Optic Chiasm / anatomy & histology. Optic Chiasm / pathology. Optic Chiasm / surgery. Pituitary Diseases / etiology. Pituitary Diseases / physiopathology. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Subarachnoid Space / anatomy & histology. Subarachnoid Space / surgery. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 16888556.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Dusick JR, Esposito F, Kelly DF, Cohan P, DeSalles A, Becker DP, Martin NA: The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors. J Neurosurg; 2005 May;102(5):832-41
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  • Twenty-six procedures for tumor removal were performed in 24 patients (ages 9-79 years), including two repeated operations for residual tumor.
  • Gross-total removal could be accomplished in only 46% of patients, with near-gross-total removal or better in 74% of 23 patients (five of eight with craniopharyngiomas, six of seven with meningiomas, five of six with Rathke cleft cysts, and one of two with a dermoid or epidermoid cyst); a patient with a lymphoma only underwent biopsy.
  • Of 13 patients with tumor-related visual loss, 85% improved postoperatively.
  • [MeSH-major] Brain Neoplasms / surgery. Minimally Invasive Surgical Procedures / methods. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Diseases / surgery. Central Nervous System Cysts / surgery. Child. Craniopharyngioma / surgery. Epidermal Cyst / surgery. Humans. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Pituitary Neoplasms / surgery. Postoperative Complications. Sphenoid Bone. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2005 May;102(5):825-7; discussion 827-8 [15926704.001]
  • (PMID = 15926706.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Liu WM, Ni M, Jia W, Guan SS, Jia GJ: [Therapeutic strategy for intrasellar cystic lesions]. Zhonghua Yi Xue Za Zhi; 2010 Nov 9;90(41):2932-4
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  • OBJECTIVE: To make a clear distinction of intrasellar cystic lesions: craniopharyngioma (CR), Rathke's cleft cyst (RCC), cystic pituitary adenoma (PA) and intrasellar arachnoid cyst (AC).
  • METHODS: A total of 72 adult patients underwent transsphenoidal approach for the removal of intrasellar cystic lesions.
  • These adult patients included CR (n = 10), RCC (n = 27), cystic PA (n = 32) and 1 patient with AC (n = 1).
  • Cystic PA had post-contrasting enhancement in cyst wall because of tumor tissue.
  • CONCLUSION: Craniopharyngioma, Rathke's cleft cyst, cystic pituitary adenoma and intrasellar arachnoid cyst are a spectrum of diseases with different therapeutic strategies.
  • [MeSH-major] Arachnoid Cysts / surgery. Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Central Nervous System Cysts / classification. Central Nervous System Cysts / surgery. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 21211400.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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48. Aquilina K, O'Brien DF, Farrell MA, Bolger C: Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature. J Neurosurg; 2006 Aug;105(2):330-3
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  • [Title] Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature.
  • The authors report on the case of a craniopharyngioma arising in the cerebellopontine angle (CPA) in a patient with Gardner syndrome.
  • Although familial adenomatous polyposis (FAP) is associated with intracranial neoplasms, the current case is only the third reported craniopharyngioma in a patient with Gardner syndrome.
  • Two of these tumors, including that of the current case, originated in the CPA, an unusual location for craniopharyngiomas.
  • The literature concerning FAP and its associations with intracranial neoplasia, as well as the pathogenesis of craniopharyngiomas in the posterior fossa, is discussed.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Craniopharyngioma / surgery. Gardner Syndrome / surgery
  • [MeSH-minor] Adult. Cerebellum / pathology. Cerebellum / surgery. Diagnosis, Differential. Fibroma / diagnosis. Fibroma / genetics. Fibroma / pathology. Fibroma / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / genetics. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Scalp / pathology. Scalp / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 17219843.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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49. Okuyama T, Fukuyama A, Fukuyama K, Ikeno K, Araki H, Okada K, Sohma N: [Three-dimensional imaging of the optic nerve using magnetic resonance angiography--application to anterior communicating artery aneurysm and craniopharingioma]. No Shinkei Geka; 2005 Apr;33(4):351-5
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  • The optic nerve and brain tumor were traced with paintbrush from one sheet to another of the reformed images after subtraction of the blood vessels around the anterior communicating artery in these reformed images, and then three-dimensional images were constructed.
  • The optic nerve and anterior communicating arterial aneurysm or brain tumor were both observed in the overlapped 3D-SSD (shaded surface display) images.
  • Three-dimensional images of the optic nerve and anterior communicating artery aneurysm or brain tumor were able to be made in all cases.
  • As a preoperative investigation for anterior communicating artery aneurysm or suprasellar brain tumor, we considered that three-dimensional imaging of the optic nerve is useful in the operative approach because the optic nerve acts as a merkmal for the anterior communicating aneurysm or brain tumor.
  • [MeSH-major] Craniopharyngioma / diagnosis. Imaging, Three-Dimensional. Intracranial Aneurysm / diagnosis. Magnetic Resonance Angiography. Optic Nerve / pathology. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Aneurysm, Ruptured / diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 15830541.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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50. Shirane R, Hayashi T, Tominaga T: Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern. Childs Nerv Syst; 2005 Aug;21(8-9):669-78
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  • [Title] Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern.
  • METHOD: Forty-two patients who were surgically treated for craniopharyngiomas extending outside the sellar-suprasellar region were evaluated.
  • CONCLUSION: In our experience, the fronto-basal interhemispheric approach, even through a small craniotomy window, is a valid choice for the removal of craniopharyngiomas extending outside the sellar-suprasellar region.
  • This approach offers a safe and minimally invasive means of treating craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Frontal Lobe / surgery. Neurosurgical Procedures. Pituitary Neoplasms / surgery. Sella Turcica / surgery
  • [MeSH-minor] Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging / methods. Male. Middle Aged. Postoperative Period. Skull Base / surgery. Tomography, X-Ray Computed / methods

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  • (PMID = 16034620.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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51. Hirunpat S, Tanomkiat W, Sriprung H, Chetpaophan J: Optic tract edema: a highly specific magnetic resonance imaging finding for the diagnosis of craniopharyngiomas. Acta Radiol; 2005 Jul;46(4):419-23
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  • [Title] Optic tract edema: a highly specific magnetic resonance imaging finding for the diagnosis of craniopharyngiomas.
  • PURPOSE: To clarify the accuracy, sensitivity, and specificity of optic tract edema in the diagnosis of craniopharyngiomas.
  • The spread of edema surrounding the tumor on the coronal TSE T2-weighted images was analyzed.
  • RESULTS: Edema along the optic tracts was detected in 7 of 11 craniopharyngiomas, giving a sensitivity of 63.6% (95% CI = 30.8-89.1) for our series and 66.7% (95% CI = 47.2-82.7) for the pooled numbers.
  • None of the 28 pituitary macroadenomas, 4 meningiomas, 2 hypothalamic astrocytomas, 2 germinomas, 1 mixed-germ cell tumor and 1 arachnoid cyst in our study showed edema of the optic pathways.
  • CONCLUSION: Optic tract edema, commonly seen in craniopharyngiomas, is a useful MR finding for distinguishing craniopharyngiomas from other parasellar tumors with considerable sensitivity and high specificity.
  • [MeSH-major] Craniopharyngioma / diagnosis. Edema / diagnosis. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / diagnosis. Visual Pathways / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity


52. Chen C, Cui Y, Huang X: [Clinical analysis of isolated sphenoid disease first manifesting headache and/or ophthalmic symptoms]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Jul;20(14):628-9, 633
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  • The diagnosis confirmed by CT or MRI and pathology included 7 cases with isolated sphenoiditis, 4 with mycosis, 3 with sphenoid cysts, 6 with purulent sphenoid cysts, 2 with polyps and sphenoiditis, 1 with foreign body, 1 with craniopharyngioma, and 1 with oncocytoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Diagnostic Errors. Endoscopy. Female. Headache / diagnosis. Humans. Imaging, Three-Dimensional. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 17017183.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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53. Jalali R, Budrukkar A, Sarin R, Sharma DS: High precision conformal radiotherapy employing conservative margins in childhood benign and low-grade brain tumours. Radiother Oncol; 2005 Jan;74(1):37-44
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  • [Title] High precision conformal radiotherapy employing conservative margins in childhood benign and low-grade brain tumours.
  • BACKGROUND AND PURPOSE: To report local control and follow up outcome data of high precision conformal radiotherapy in childhood brain tumours.
  • MATERIALS AND METHODS: Between December 1999 and December 2002, 26 children (17 boys and 9 girls, median age 11.5 years) with incompletely excised or recurrent benign and low-grade brain tumours [13 craniopharyngiomas, 11 low-grade gliomas (LGG) and 2 others] were treated with three-dimensional (3D) conformal radiotherapy (CRT) (12 patients) and stereotactic conformal radiotherapy (SCRT) (14 patients).
  • One patient with craniopharyngioma on a routine imaging revealed a mild asymptomatic cyst enlargement, which resolved with conservative management.
  • CONCLUSION: High-precision conformal techniques delivering irradiation to a computer generated target volume employing 7-10 mm 3D margins beyond the visible tumour and/or resected tumour bed appear to be safe in children with incompletely resected or recurrent benign and low-grade brain tumours, based on these data.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Craniopharyngioma / radiotherapy. Glioma / radiotherapy. Radiotherapy, Conformal
  • [MeSH-minor] Adolescent. Adult. Brain Diseases / etiology. Child. Child, Preschool. Combined Modality Therapy. Cysts / etiology. Dose Fractionation. Female. Humans. Male. Radiation Injuries. Survival Analysis. Treatment Outcome

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  • (PMID = 15683667.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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54. Zhou L, Luo L, Xu J, Li Q, Chen J, Jiang S, Cai B, You C: Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes. J Neurol Neurosurg Psychiatry; 2009 Oct;80(10):1150-4
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  • [Title] Craniopharyngiomas in the posterior fossa: a rare subgroup, diagnosis, management and outcomes.
  • OBJECTIVE: Craniopharyngiomas with predominant pars in the posterior fossa are very rare and extremely overlooked.
  • The purpose of this study was to explore the differing characteristics of posterior fossa craniopharyngiomas.
  • METHODS: Seven patients with pathologically proven craniopharyngiomas located in the posterior fossa were retrospectively investigated.
  • CONCLUSIONS: Posterior fossa craniopharyngiomas are rare and may be considered an independent subgroup of classifications.
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Infratentorial Neoplasms / diagnosis. Infratentorial Neoplasms / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Cohort Studies. Female. Humans. Male. Retrospective Studies. Treatment Outcome

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  • [RetractionIn] J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):942 [20682723.001]
  • (PMID = 19762904.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
  • [Publication-country] England
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55. Gardner PA, Kassam AB, Snyderman CH, Carrau RL, Mintz AH, Grahovac S, Stefko S: Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series. J Neurosurg; 2008 Jul;109(1):6-16
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  • [Title] Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series.
  • OBJECT: Craniopharyngiomas are challenging tumors that most frequently occur in the sellar or suprasellar regions.
  • METHODS: The authors performed a retrospective review of all patients who underwent a purely endoscopic, expanded endonasal approach (EEA) for the resection of craniopharyngiomas at their institution between June 1999 and February 2006.
  • RESULTS: Sixteen patients underwent endoscopic EEA for the resection of craniopharyngiomas.
  • Three elderly patients with vision loss underwent planned debulking, 1 patient with vision loss and a moderate-sized tumor had express wishes for debulking, and 1 patient had a separate, third ventricular nodule that was not resected.
  • CONCLUSIONS: Endoscopic EEA for the resection of craniopharyngiomas provides acceptable results and holds the potential to improve outcomes.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Endoscopy. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Male. Middle Aged. Nasal Cavity. Neoplasm Invasiveness. Retrospective Studies. Treatment Outcome


56. Dusick JR, Fatemi N, Mattozo C, McArthur D, Cohan P, Wang C, Swerdloff RS, Kelly DF: Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas. Surg Neurol; 2008 Nov;70(5):482-90; discussion 490-1
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  • [Title] Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas.
  • Herein we present the rates and risk factors of new hormonal failure and recovery in patients undergoing surgery for either an RCC, craniopharyngioma, or tuberculum sella meningioma.
  • METHODS: All consecutive patients treated over an 8-year period by endonasal surgery for an RCC, craniopharyngioma, or tuberculum sella meningioma were analyzed.
  • Patient characteristics, tumor size, intraoperative and postoperative events, and extent of tumor resection were correlated with new or resolved hypopituitarism.
  • RESULTS: In total, 50 patients with an RCC, 18 with a craniopharyngioma and 13 with tuberculum sellae meningioma, were analyzed.
  • New anterior pituitary failure and permanent DI occurred as follows: in RCCs, 6% and 2%; in craniopharyngiomas, 31% and 39%; and in meningiomas, 9% and 0%.
  • Overall, improved hormonal function occurred in 57% of patients with an RCC including recovery of one or more anterior axes in 9 (41%) of 22 patients and resolution of hyperprolactinemia in 12 (67%) of 18 patients; no patients with a craniopharyngioma or meningioma had resolution of hypopituitarism.
  • CONCLUSIONS: New hypopituitarism after transsphenoidal surgery occurs in approximately one third of patients with a craniopharyngioma and in less than 10% of patients with an RCC or suprasellar meningioma.
  • Hormonal function improves in the majority of patients undergoing drainage of an RCC but is unlikely to occur after removal of a craniopharyngioma or suprasellar meningioma.
  • [MeSH-major] Central Nervous System Cysts / surgery. Craniopharyngioma / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Pituitary Gland / physiopathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cohort Studies. Female. Humans. Male. Middle Aged. Pituitary Function Tests. Pituitary Hormones, Anterior / metabolism. Pituitary Hormones, Posterior / metabolism. Retrospective Studies. Treatment Outcome

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  • [CommentIn] Surg Neurol. 2009 Dec;72(6):643-4; author reply 644-7 [20082835.001]
  • (PMID = 18482750.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pituitary Hormones, Anterior; 0 / Pituitary Hormones, Posterior
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57. Srimanee D, Bhidayasiri R, Phanthumchinda K: Extrapontine myelinolysis in preoperative sellar region tumor: report of two cases. J Med Assoc Thai; 2009 Nov;92(11):1548-53
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  • [Title] Extrapontine myelinolysis in preoperative sellar region tumor: report of two cases.
  • The authors describe two cases of preoperative sellar region tumor associated with hypopituitarism and secondary adrenal insufficiency.
  • The first case was a 35-year-old man with craniopharyngioma who developed generalized dystonia after rapid correction of hyponatremia.
  • [MeSH-major] Craniopharyngioma / diagnosis. Myelinolysis, Central Pontine / diagnosis. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Adrenal Insufficiency / complications. Adult. Diagnosis, Differential. Fatal Outcome. Humans. Hyponatremia / complications. Hypopituitarism / complications. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 19938750.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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58. Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF, Attanasio AF, HypoCCS International Advisory Board: Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database. J Clin Endocrinol Metab; 2009 Feb;94(2):392-9
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  • [Title] Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database.
  • BACKGROUND: GH therapy in adult patients with GH deficiency (GHD) was approved over 10 yr ago, and the indication has subsequently gained broad acceptance.
  • RESULTS: Over the decade, there was a decrease in patients enrolled with diagnoses of pituitary adenoma (50.2 to 38.6%; P < 0.001), craniopharyngioma (13.3 to 8.4%; P = 0.005) and pituitary hemorrhage (5.8 to 2.8%; P = 0.001); increases in idiopathic GHD (13.9 to 19.3%; P < 0.001), less common diagnoses (7.4 to 15.8%; P < 0.001), and undefined/unknown diagnoses (1.3 to 8.6%; P < 0.001) were observed.
  • Over the decade (1996--2005), idiopathic GHD was reported for 16.7% of patients, and more than half of these had adult onset GHD.
  • In the idiopathic adult onset group, 40.2% had isolated GHD; 18.3 and 4.4% had a stimulation test GH peak of at least 3.0 and 5.0 microg/liter, respectively.
  • CONCLUSIONS: Significant shifts in diagnostic patterns have occurred since approval of the adult GHD indication, with a trend to less severe forms of GHD.
  • [MeSH-minor] Adult. Age of Onset. Arginine / analysis. Diagnostic Techniques, Endocrine / trends. Female. Growth Hormone-Releasing Hormone / analysis. Humans. Insulin Resistance / physiology. Male. Middle Aged. Pituitary Diseases / complications. Pituitary Diseases / diagnosis

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  • (PMID = 19001512.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone; 9034-39-3 / Growth Hormone-Releasing Hormone; 94ZLA3W45F / Arginine
  • [Investigator] Attanasio AF; Terme A; Beck-Peccoz P; Blum WF; Bouillon R; Chanson P; Kremlin-Bicêtre L; Chihara K; Clemmons DR; Cutler GB; Erfurth EM; Hartman M; Ho KY; Jung H; Kleinberg D; Lamberts SW; Melmed S; Robinson LL; Ross RJ; Shimatsu A; Strasburger CJ; Webb SM; Woodmansee W; Zimmermann A
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59. Choi SH, Kwon BJ, Na DG, Kim JH, Han MH, Chang KH: Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI. Clin Radiol; 2007 May;62(5):453-62
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  • [Title] Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI.
  • AIMS: To determine the differential magnetic resonance imaging (MRI) features of pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions.
  • MATERIALS AND METHODS: The MRI images of 64 patients with pituitary adenoma (n=38), craniopharyngioma (n=13), or Rathke cleft cyst (n=13) were retrospectively reviewed by three neuroradiologists.
  • A superiorly lobulated shape, third ventricle compression by superior tumour extension, mixed solid and cystic characteristics, and reticular enhancement of the solid portion were more common in craniopharyngiomas (p<0.017).
  • Finally, an ovoid shape, a small tumour volume, cystic characteristics, and no or thin cyst wall enhancement were more common in Rathke cleft cysts (p<0.017).
  • The flowchart yielded diagnostic accuracies as follows: 92.1% in pituitary adenoma; 92.3% in craniopharyngioma; 92.3% in Rathke cleft cyst; and 92.2% overall.
  • [MeSH-major] Adenoma / pathology. Central Nervous System Cysts / pathology. Craniopharyngioma / pathology. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Radiology Information Systems. Retrospective Studies


60. Schmalisch K, Beschorner R, Psaras T, Honegger J: Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature. Acta Neurochir (Wien); 2010 Feb;152(2):313-9; discussion 319
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  • [Title] Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature.
  • PURPOSE: Seeding of craniopharyngioma has been rarely reported.
  • METHODS: The first patient was a 13-year-old boy who had initially undergone radical excision of a suprasellar and retrosellar craniopharyngioma by a right pterional approach.
  • Postoperative MRI showed no evidence of residual tumor.
  • Two years later, MRI revealed a local recurrence and in addition a separated cystic tumor on the right side adjacent to the middle cerebral artery consistent with seeding along the surgical route.
  • On histopathological examination, both, the local recurrent tumor and the distant deposit turned out to be adamantinomatous craniopharyngiomas.
  • The second patient was a 27-year-old woman who was operated on for the first time via a right pterional and 1 year later for a recurrent craniopharyngioma via a transsphenoidal approach.
  • This deposit in the operative pathway was found to be an adamantinomatous craniopharyngioma, as was the initial tumor.
  • The recent control MRT revealed a right parietal intracranial tumor with peripheral contrast enhancement, which was located distant to the former craniotomy.
  • The tumor was removed and histopathological examination revealed an adamantinomatous craniopharyngioma in accordance with the initial tumor.
  • CONCLUSION: Although craniopharyngiomas exhibit a benign histopathological pattern, cerebrospinal fluid seeding along the surgical route or along the CSF pathways has been observed.
  • Ectopic recurrence of craniopharyngioma suggests that meticulous protection of the whole surgical field and careful handling of the tumor during the operation are required.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Metastasis / pathology. Neoplasm Seeding. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Craniotomy. Female. Frontal Bone / pathology. Frontal Bone / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Parietal Bone / pathology. Parietal Bone / surgery. Reoperation. Treatment Outcome

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  • (PMID = 19859655.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 31
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61. Pekmezci M, Louie J, Gupta N, Bloomer MM, Tihan T: Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005. Neurosurgery; 2010 Nov;67(5):1341-9; discussion 1349
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  • [Title] Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005.
  • BACKGROUND: Craniopharyngiomas are rare epithelial tumors that are presumed to arise from the remnants of Rathke's pouch.
  • OBJECTIVE: This study was designed to evaluate the outcome characteristics of craniopharyngiomas treated in a single institution and to determine whether the adamantinomatous craniopharyngioma should be considered more aggressive than a World Health Organization (WHO) grade I neoplasm.
  • METHODS: We identified all patients with craniopharyngioma given their diagnoses at University of California, San Francisco in a 20-year period and performed a retrospective analysis of clinicopathological and outcome characteristics.
  • CONCLUSION: Adamantinomatous craniopharyngioma is a locally aggressive neoplasm with a significant rate of recurrence.
  • This is not in keeping with the current designation of a WHO grade I neoplasm.
  • Given the high numbers of "silent" defects, formal visual field testing should be performed in all patients with craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / mortality. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / mortality. Pituitary Neoplasms / mortality. Pituitary Neoplasms / surgery. Postoperative Complications / mortality
  • [MeSH-minor] Adolescent. Adult. Aged. California / epidemiology. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Longitudinal Studies. Male. Middle Aged. Prevalence. Risk Assessment. Risk Factors. Survival Analysis. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20871436.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Coppens JR, Couldwell WT: Staged use of the transsphenoidal approach to resect superior third ventricular craniopharyngiomas. Minim Invasive Neurosurg; 2010 Feb;53(1):40-3
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  • [Title] Staged use of the transsphenoidal approach to resect superior third ventricular craniopharyngiomas.
  • INTRODUCTION: Craniopharyngiomas are benign tumors, usually originating from the infundibulum or tuber cinereum.
  • Large craniopharyngiomas that invade the upper third of the third ventricle are a common reason for patients to need a second operation to accomplish a gross total resection.
  • Transsphenoidal approaches are being increasingly used in the treatment of craniopharyngiomas.
  • Large craniopharyngiomas involving the superior third ventricle are most commonly resected through a staged approach, often involving a transcortical or interhemispheric route.
  • CASE REPORT: The authors describe the use of an extended transsphenoidal approach as a second-stage operation to resect the intraventricular component of a large craniopharyngioma in an illustrative case.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Neuroendoscopy / methods. Pituitary Neoplasms / surgery. Sphenoid Sinus / surgery. Third Ventricle / surgery
  • [MeSH-minor] Adult. Decompression, Surgical / methods. Humans. Male. Neoplasm, Residual / diagnosis. Neoplasm, Residual / surgery. Postoperative Complications / diagnosis. Reoperation

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20376745.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Luu QT, Loredo LN, Archambeau JO, Yonemoto LT, Slater JM, Slater JD: Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report. Cancer J; 2006 Mar-Apr;12(2):155-9
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  • [Title] Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report.
  • This retrospective preliminary review evaluated the efficacy and toxicity of fractionated proton radiotherapy in the management of pediatric craniopharyngioma.
  • All had undergone at least one tumor resection.
  • DISCUSSION: Fractionated proton radiotherapy is an effective treatment for children with craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy. Protons / therapeutic use. Radiotherapy, Conformal / methods
  • [MeSH-minor] Adolescent. Adult. California / epidemiology. Child. Dose Fractionation. Female. Humans. Male. Radiotherapy, Adjuvant. Retrospective Studies. Salvage Therapy / methods

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  • (PMID = 16630407.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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64. Dehdashti AR, de Tribolet N: Frontobasal interhemispheric trans-lamina terminalis approach for suprasellar lesions. Neurosurgery; 2005 Apr;56(2 Suppl):418-24; discussion 418-24
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  • [MeSH-major] Brain Diseases / surgery. Frontal Sinus / surgery. Neurosurgical Procedures. Sella Turcica
  • [MeSH-minor] Adult. Cerebral Angiography. Cerebral Ventricle Neoplasms / radiography. Cerebral Ventricle Neoplasms / surgery. Craniopharyngioma / radiography. Craniopharyngioma / surgery. Craniotomy. Dissection. Dura Mater / surgery. Female. Humans. Intracranial Arteriovenous Malformations / radiography. Intracranial Arteriovenous Malformations / surgery. Male. Pituitary Neoplasms / radiography. Pituitary Neoplasms / surgery. Postoperative Care. Third Ventricle / radiography. Tomography, X-Ray Computed

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  • [CommentIn] Neurosurgery. 2008 Jun;62(6 Suppl 3):1233-9 [18695544.001]
  • (PMID = 15794839.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] United States
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65. Müller HL, Gebhardt U, Faldum A, Emser A, Etavard-Gorris N, Kolb R, Sörensen N: Functional capacity and body mass index in patients with sellar masses--cross-sectional study on 403 patients diagnosed during childhood and adolescence. Childs Nerv Syst; 2005 Jul;21(7):539-45
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  • METHODS: FC was evaluated using the ability scale Fertigkeitenskala Münster-Heidelberg in 403 children and adolescents with sellar masses (276 craniopharyngioma, 14 germinoma, 21 optic/chiasmatic glioma, 40 hypothalamic glioma, 13 cysts of Rathke's cleft and 39 other sellar masses).
  • The second model showed BMI at diagnosis (p<0,001), hypothalamic involvement (p<0.001) and craniopharyngioma (p=0,004) to influence BMI at the latest evaluation.
  • [MeSH-major] Body Mass Index. Craniopharyngioma / diagnosis. Craniopharyngioma / physiopathology. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / physiopathology
  • [MeSH-minor] Adolescent. Adult. Chi-Square Distribution. Child. Cross-Sectional Studies. Female. Humans. Hypothalamus / pathology. Hypothalamus / physiopathology. Male. Neuropsychological Tests. Prospective Studies. Quality of Life. Retrospective Studies

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  • (PMID = 15889310.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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66. Verhelst J, Abs R: Cardiovascular risk factors in hypopituitary GH-deficient adults. Eur J Endocrinol; 2009 Nov;161 Suppl 1:S41-9
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  • The added value of the different KIMS papers over previous research is that KIMS involves a much larger number of patients, that lipid concentrations and IGF1 are measured in a single central laboratory, and that the effects of GH replacement therapy can be followed longer than the duration of earlier trials.
  • By the large number of patients, KIMS gives insight into the effects of GH in different patients' subgroups such as elderly patients, patients with idiopathic GHD, patients with craniopharyngioma, patients after irradiation, and so on.

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  • (PMID = 19684057.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 12629-01-5 / Human Growth Hormone
  • [Number-of-references] 66
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67. Yang I, Sughrue ME, Rutkowski MJ, Kaur R, Ivan ME, Aranda D, Barani IJ, Parsa AT: Craniopharyngioma: a comparison of tumor control with various treatment strategies. Neurosurg Focus; 2010 Apr;28(4):E5
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  • [Title] Craniopharyngioma: a comparison of tumor control with various treatment strategies.
  • OBJECT: Craniopharyngiomas have a propensity to recur after resection, potentially causing death through their aggressive local behavior in their critical site of origin.
  • Recent data suggest that subtotal resection (STR) followed by adjuvant radiotherapy (XRT) may be an appealing substitute for gross-total resection (GTR), providing similar rates of tumor control without the morbidity associated with aggressive resection.
  • Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas.
  • METHODS: The authors performed a comprehensive search of the English language literature to identify studies publishing outcome data on patients undergoing surgery for craniopharyngioma.
  • RESULTS: There were 442 patients who underwent tumor resection.
  • CONCLUSIONS: Given the relative rarity of craniopharyngioma, this study provides estimates of outcome for a variety of treatment combinations, as not all treatments are an option for all patients with these tumors.
  • [MeSH-major] Craniopharyngioma / therapy. Pituitary Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Hypophysectomy / methods. Kaplan-Meier Estimate. Male. Middle Aged. Pituitary Irradiation. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 20367362.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 282
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68. Combs SE, Thilmann C, Huber PE, Hoess A, Debus J, Schulz-Ertner D: Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy. Cancer; 2007 Jun 1;109(11):2308-14
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  • [Title] Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy.
  • BACKGROUND: The long-term outcome in patients with craniopharyngiomas treated with fractionated stereotactic radiotherapy (FSRT) was evaluated.
  • METHODS: A total of 40 patients with craniopharyngiomas were treated between May 1989 and July 2006 with FSRT.
  • Most patients were treated for tumor progression after surgery.
  • CONCLUSIONS: The long-term outcome of FSRT for craniopharyngiomas is excellent with regard to local control as well as treatment-related side effects.
  • [MeSH-major] Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiotherapy / methods. Stereotaxic Techniques
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17469176.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. de Divitiis E, Cavallo LM, Cappabianca P, Esposito F: Extended endoscopic endonasal transsphenoidal approach for the removal of suprasellar tumors: Part 2. Neurosurgery; 2007 Jan;60(1):46-58; discussion 58-9
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  • The series consisted of seven pituitary adenomas, seven craniopharyngiomas, three suprasellar Rathke's cleft cysts, two tuberculum sellae meningiomas, and one pilocytic astrocytoma of the chiasm.
  • RESULTS: Tumor removal, as assessed by postoperative magnetic resonance imaging, revealed complete removal of the lesion in four out of seven pituitary adenomas, five out of seven craniopharyngiomas, three out of three Rathke's cleft cysts, and two out of two tuberculum sellae meningiomas.
  • One patient (5%) with craniopharyngioma had a postoperative cerebrospinal fluid leak that required reoperation.
  • [MeSH-major] Brain Neoplasms / surgery. Nasal Cavity / surgery. Neuroendoscopy / methods. Sphenoid Sinus / surgery
  • [MeSH-minor] Adult. Aged. Central Nervous System Neoplasms / diagnosis. Central Nervous System Neoplasms / radiography. Central Nervous System Neoplasms / surgery. Female. Humans. Male. Middle Aged. Sphenoid Bone / radiography. Sphenoid Bone / surgery

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  • (PMID = 17228252.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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70. Gonçalves MI, Radzinsky TC, da Silva NS, Chiari BM, Consonni D: Speech-language and hearing complaints of children and adolescents with brain tumors. Pediatr Blood Cancer; 2008 Mar;50(3):706-8
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  • [Title] Speech-language and hearing complaints of children and adolescents with brain tumors.
  • Central nervous system (CNS) tumors generally leave sequelae that may compromise speech, language, swallowing, hearing, and voice functions.
  • This report describes the incidence of speech-language and hearing complaints and disorders in children and adolescents with CNS tumor under treatment at one of the most important Brazilian reference center for pediatric cancer.
  • [MeSH-major] Brain Neoplasms / complications. Hearing Loss / etiology. Language Disorders / etiology. Speech Disorders / etiology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Astrocytoma / complications. Astrocytoma / drug therapy. Child. Child, Preschool. Craniopharyngioma / complications. Craniopharyngioma / drug therapy. Deglutition Disorders / etiology. Ependymoma / complications. Ependymoma / drug therapy. Facial Paralysis / etiology. Female. Humans. Infant. Male. Medulloblastoma / complications. Medulloblastoma / drug therapy


71. Ogawa Y, Tominaga T: A partially ossified solid and cystic Rathke cleft cyst. J Neurosurg; 2010 Jun;112(6):1324-6
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  • [Title] A partially ossified solid and cystic Rathke cleft cyst.
  • A Rathke cleft cyst is considered to arise from the remnants of the Rathke pouch, and it consists of single cuboidal or columnar epithelium including cilia and goblet cells, which secrete mucus into the cyst.
  • A 21-year-old woman presented with an extremely rare case of a solid and cystic Rathke cleft cyst with partial ossification, manifesting as bitemporal hemianopia.
  • Single cuboidal epithelium including goblet cells and cilia was found along this granulation, and the diagnosis was a Rathke cleft cyst.
  • An ossified Rathke cleft cyst is extremely rare, and a solid Rathke cleft cyst has not before been reported.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Central Nervous System Cysts / pathology. Central Nervous System Cysts / surgery. Craniopharyngioma / surgery. Ossification, Heterotopic / pathology. Ossification, Heterotopic / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Female. Hemianopsia / etiology. Humans. Magnetic Resonance Imaging. Nerve Compression Syndromes / pathology. Nerve Compression Syndromes / surgery. Optic Chiasm / pathology. Optic Chiasm / surgery. Pituitary Gland / pathology. Visual Fields / physiology. Young Adult

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  • [CommentIn] J Neurosurg. 2010 Jun;112(6):1322-3; discussion 1323 [19961318.001]
  • (PMID = 19961317.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Crom DB: Metabolic abnormalities in an adult survivor of pediatric craniopharyngioma. Oncology (Williston Park); 2008 Jul;22(8 Suppl Nurse Ed):43-6
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  • [Title] Metabolic abnormalities in an adult survivor of pediatric craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / complications. Craniopharyngioma / nursing. Endocrine System Diseases / etiology. Endocrine System Diseases / nursing. Pituitary Neoplasms / complications. Pituitary Neoplasms / nursing
  • [MeSH-minor] Adult. Child. Combined Modality Therapy. Humans. Male. Neurosurgical Procedures / adverse effects. Radiotherapy / adverse effects. Survivors

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  • (PMID = 19856572.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Jane JA Jr, Kiehna E, Payne SC, Early SV, Laws ER Jr: Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas. Neurosurg Focus; 2010 Apr;28(4):E9
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  • [Title] Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas.
  • OBJECT: Although the transsphenoidal approach for subdiaphragmatic craniopharyngiomas has been performed for many years, there are few reports describing the role of the endoscopic transsphenoidal technique for suprasellar craniopharyngiomas.
  • The purpose of this study was to report the outcomes of the endoscopic transsphenoidal approach for adults with craniopharyngiomas in whom the goal was gross-total resection.
  • CONCLUSIONS: The authors have achieved a high rate of radical resection and symptomatic improvement with the endoscopic transsphenoidal technique for both subdiaphragmatic (sellar/suprasellar) and supradiaphragmatic (suprasellar) craniopharyngiomas.
  • Endoscopic assessment of tumor resection may be more sensitive for residual tumor than the first postoperative MR imaging study.
  • [MeSH-major] Craniopharyngioma / surgery. Neuroendoscopy / methods. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Diabetes Insipidus / etiology. Female. Humans. Hypopituitarism / etiology. Magnetic Resonance Imaging. Male. Microsurgery / methods. Middle Aged. Postoperative Complications / etiology. Sella Turcica / pathology. Sella Turcica / surgery. Sphenoid Sinus. Treatment Outcome. Tumor Burden. Vision Disorders / etiology

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  • (PMID = 20367523.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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74. Campbell PG, McGettigan B, Luginbuhl A, Yadla S, Rosen M, Evans JJ: Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas. Neurosurg Focus; 2010 Apr;28(4):E8
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  • [Title] Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas.
  • OBJECT: The expanded endoscopic approach to craniopharyngiomas has recently been described in several small case series.
  • METHODS: Between September 2006 and September 2009, 14 patients underwent a purely endoscopic, endonasal approach for resection of newly diagnosed craniopharyngiomas.
  • These procedures represent index surgeries; no patient had undergone previous tumor resection.
  • Additionally, a review of the English literature was performed to evaluate outcomes of similar endoscopic techniques for resection of craniopharyngiomas.
  • CONCLUSIONS: The endoscopic endonasal approach is a minimally invasive alternative to open transcranial approaches for select craniopharyngiomas.
  • Similar to previous transcranial series, rates of endocrinopathy and gross-total resection were dependent upon the adherence of the tumor capsule to the hypothalamus, pituitary stalk, and associated vasculature.
  • [MeSH-major] Craniopharyngioma / surgery. Neuroendoscopy / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebrospinal Fluid Rhinorrhea / etiology. Diabetes Insipidus / etiology. Female. Hemianopsia / etiology. Humans. Male. Middle Aged. Nasal Cavity. Neurosurgical Procedures / methods. Postoperative Complications / etiology. Treatment Outcome. Vision Disorders / etiology. Visual Fields / physiology

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  • [CommentIn] Neurosurg Focus. 2010 Apr;28(4):E8a; discussion E8b [20367366.001]
  • (PMID = 20367365.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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75. Carroll C, Krolikowski K, Mukonoweshuro W, Jones J, Hanemann CO: Unilateral cerebral hemisphere oedema as a peri-ictal phenomenon. J Neurol; 2010 Dec;257(12):2094-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Brain Edema / diagnosis. Craniopharyngioma / diagnosis. Epilepsy / diagnosis
  • [MeSH-minor] Adult. Cerebral Cortex / diagnostic imaging. Cerebral Cortex / pathology. Humans. Male. Radiography

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  • [Cites] Seizure. 2009 Mar;18(2):104-8 [18723376.001]
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  • (PMID = 20632028.001).
  • [ISSN] 1432-1459
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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76. Cappabianca P, Esposito F, Esposito I, Cavallo LM, Leone CA: Use of a thrombin-gelatin haemostatic matrix in endoscopic endonasal extended approaches: technical note. Acta Neurochir (Wien); 2009 Jan;151(1):69-77; discussion 77
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  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adult. Aged. Brain Neoplasms / pathology. Brain Neoplasms / surgery. Craniopharyngioma / pathology. Craniopharyngioma / surgery. Female. Humans. Intraoperative Complications / drug therapy. Intraoperative Complications / etiology. Intraoperative Complications / prevention & control. Male. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery. Middle Aged. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19129962.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / FloSeal Matrix
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77. Berlis A, Vesper J, Ostertag C: Stent placement for intracranial cysts by combined stereotactic/endoscopic surgery. Neurosurgery; 2006 Oct;59(4 Suppl 2):ONS474-9; discussion ONS479-80
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  • The authors present a new treatment method with internal drainage of cysts into the ventricular system using a balloon-mounted vascular stent.
  • METHODS: Six patients with cysts of low-grade gliomas, one with monocystic craniopharyngioma, and one with suprasellar arachnoid cyst were treated between September 2003 and May 2005.
  • The first patient showed recurrence of the tumor cyst 3 months after initial treatment with a Herkulink stent (5 x 18 mm), followed by retreatment with an Omnilink stent (6 x 28 mm; Guidant Corp., Santa Clara, CA).
  • [MeSH-major] Brain Diseases / surgery. Cysts / surgery. Endoscopy / methods. Neurosurgical Procedures / methods. Prosthesis Implantation / methods. Stents. Stereotaxic Techniques
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17041520.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Hasegawa T, Kobayashi T, Kida Y: Tolerance of the optic apparatus in single-fraction irradiation using stereotactic radiosurgery: evaluation in 100 patients with craniopharyngioma. Neurosurgery; 2010 Apr;66(4):688-94; discussion 694-5
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  • [Title] Tolerance of the optic apparatus in single-fraction irradiation using stereotactic radiosurgery: evaluation in 100 patients with craniopharyngioma.
  • OBJECTIVE: To determine the limiting dose to the optic apparatus in single-fraction irradiation in patients with craniopharyngioma treated with gamma knife radiosurgery (GKRS).
  • METHODS: One hundred patients with 109 craniopharyngiomas treated with GKRS were evaluated with a median follow-up period of 68 months.
  • Tumor volume varied from 0.1 to 36.0 (median, 3.3) cm.
  • RESULTS: The actuarial 5- and 10-year overall rates of survival of tumor progression after GKRS were 93% and 88%, respectively.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery. Radiosurgery / methods. Vision, Ocular / physiology
  • [MeSH-minor] Adolescent. Adult. Disease-Free Survival. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Optic Chiasm / radiation effects. Optic Nerve Diseases / etiology. Radiotherapy Dosage. Retrospective Studies. Time Factors

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  • (PMID = 20190668.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Balak N, Aras A, Isik N, Elmaci I: [Making the differential diagnosis between pituitary apoplexy and craniopharyngioma]. Neurochirurgie; 2009 Dec;55(6):600-2
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  • [Title] [Making the differential diagnosis between pituitary apoplexy and craniopharyngioma].
  • [Transliterated title] Difficulté du diagnostic différentiel entre l'apoplexie hypophysaire et le craniopharyngiome.
  • Craniopharyngioma may be difficult to distinguish from pituitary apoplexy.
  • In our patient, the tumor was confused with a craniopharyngioma because of the suprasellar extension of the tumor on magnetic resonance (MR) images and the hyperintensity in T1-weighted images, the young age of the patient, and the gradually progressive onset of the symptoms.
  • In conclusion, even without a known history of pituitary adenoma or an abrupt onset of the clinical symptoms, the diagnosis of pituitary apoplexy should be considered in a patient with a suprasellar mass hyperintensity in T1-weighted MR images, which may mimic craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / diagnosis. Pituitary Apoplexy / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Pituitary Gland / pathology. Sella Turcica / pathology. Young Adult

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  • (PMID = 19091358.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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80. Berg C, Meinel T, Lahner H, Yuece A, Mann K, Petersenn S: Diagnostic utility of the glucagon stimulation test in comparison to the insulin tolerance test in patients following pituitary surgery. Eur J Endocrinol; 2010 Mar;162(3):477-82
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  • [Title] Diagnostic utility of the glucagon stimulation test in comparison to the insulin tolerance test in patients following pituitary surgery.
  • OBJECTIVE: The glucagon stimulation test (GST) like the insulin tolerance test (ITT) stimulates both ACTH and GH secretion.
  • However, there are limited data with modern assays on sensitivity and specificity for GST in comparison to ITT.
  • The aim of this study was to evaluate the diagnostic utility of the GST for GH deficiency (GHD) and adrenal insufficiency (AI) in patients following pituitary surgery.
  • DESIGN AND PATIENTS: ITT and GST were performed within 7 days in 49 patients at least 3 months after transsphenoidal surgery.
  • Serum GH and cortisol were measured by Immulite 2000 assay (Siemens AG).
  • Receiver-operating characteristic (ROC) analysis was performed to identify the thresholds for GST.
  • RESULTS: In ITT, 18/49 cases were classified as AI.
  • ROC analysis revealed a peak cortisol value >599 nmol/l in GST for adrenal sufficiency with 100% specificity and 32% sensitivity, and a peak cortisol <277 nmol/l with >95% specificity and 72% sensitivity for AI.
  • Of the 49 subjects, 25 (51%) demonstrated levels between these cut-offs and could not be diagnosed by GST alone with sufficient accuracy.
  • Regarding GHD, 21/49 cases were classified as insufficient by ITT.
  • ROC analysis revealed a cut-off of 2.5 ng/ml with 95% sensitivity and 79% specificity.
  • Of the 49 cases, seven (14%) were discordant in terms of defining GHD, with six subjects being treated for GHD according to GST although being sufficient in ITT.
  • CONCLUSION: In our prospective series of patients with pituitary disease, GST is a potential alternative test for the assessment of GH reserve, but is a poor test for ACTH reserve.
  • Test-specific cut-offs should be applied to avoid misinterpretation.

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  • (PMID = 19996199.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Minamida Y, Mikami T, Hashi K, Houkin K: Surgical management of the recurrence and regrowth of craniopharyngiomas. J Neurosurg; 2005 Aug;103(2):224-32
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  • [Title] Surgical management of the recurrence and regrowth of craniopharyngiomas.
  • OBJECT: The authors performed a retrospective analysis of a consecutive series of craniopharyngiomas and their recurrences, which were managed with surgery alone.
  • METHODS: In the past 20 years, 37 consecutive patients with craniopharyngiomas underwent surgery without adjuvant radiotherapy.
  • Of these 37 patients, 11 experienced tumor recurrence (29.7%) during the mean follow-up period of 11.1 years.
  • Using a proper surgical approach (mainly a basal interhemispheric approach) and meticulous microsurgical techniques, total removal of the recurrent tumor was achieved in nine surgeries (52.9).
  • CONCLUSIONS: Recurrence of craniopharyngioma can be safely managed by using meticulous contemporary microsurgical techniques without additional radiotherapy.
  • The role of surgery and adjuvant radiotherapy for craniopharyngiomas may vary in the future, depending on innovations in treatment and technology.
  • Nevertheless, surgery can be still a major therapeutic option in the management of recurrent craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / pathology. Craniopharyngioma / surgery. Neoplasm Recurrence, Local / surgery. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Cognition. Disease Progression. Humans. Infant. Male. Middle Aged. Morbidity. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis

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  • (PMID = 16175850.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Nakamura Y, Kanemura Y, Yamada T, Sugita Y, Higaki K, Yamamoto M, Takahashi M, Yamasaki M: D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells. Mod Pathol; 2006 Jul;19(7):974-85
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  • [Title] D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells.
  • Some brain tumors such as anaplastic ependymoma, some medulloblastomas, glioblastoma, pineal germinoma, craniopharyngioma, choroid plexus papilloma, choroid plexus carcinoma, and meningioma showed positive immunoreactivity with D2-40.
  • Therefore, D2-40 antibody is considered a useful marker for research on developing brain and diagnosis of brain tumors, differentiation between choroid plexus carcinoma and metastatic carcinoma.
  • [MeSH-major] Antibodies, Monoclonal. Antigens, Neoplasm / analysis. Brain Neoplasms / immunology. Cerebellum / immunology. Telencephalon / immunology
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Cells, Cultured. Child, Preschool. Fetus / immunology. Gestational Age. Humans. Immunohistochemistry. Infant. Middle Aged. Neurons / cytology. Neurons / immunology. Prosencephalon / cytology. Stem Cells / cytology. Stem Cells / immunology

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  • (PMID = 16648867.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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83. Kostrzewa JP, Sunde J, Riley KO, Woodworth BA: Radiofrequency coblation decreases blood loss during endoscopic sinonasal and skull base tumor removal. ORL J Otorhinolaryngol Relat Spec; 2010;72(1):38-43
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  • [Title] Radiofrequency coblation decreases blood loss during endoscopic sinonasal and skull base tumor removal.
  • The purpose of the present study was to determine whether radiofrequency coblation decreases blood loss during endoscopic tumor removal.
  • The sinus/skull base tumors included were esthesioneuroblastoma (n = 6), melanoma (n = 3), squamous cell carcinoma (n = 3), inverted papilloma (n = 3), adenocarcinoma (n = 2), intracranial dermoid cyst (n = 2), adenoid cystic carcinoma (n = 1), craniopharyngioma (n = 1), fibromyxosarcoma (n = 1) and undifferentiated carcinoma (n = 1).
  • CONCLUSION: Radiofrequency coblation significantly decreased blood loss during endoscopic tumor removal and is a useful tool in the armamentarium of the endoscopic skull base surgeon.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Debridement / instrumentation. Female. Humans. Male. Middle Aged. Treatment Outcome. Video Recording

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  • (PMID = 20299815.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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84. Sands SA, Milner JS, Goldberg J, Mukhi V, Moliterno JA, Maxfield C, Wisoff JH: Quality of life and behavioral follow-up study of pediatric survivors of craniopharyngioma. J Neurosurg; 2005 Oct;103(4 Suppl):302-11
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  • [Title] Quality of life and behavioral follow-up study of pediatric survivors of craniopharyngioma.
  • OBJECT: The authors set out to evaluate the quality of life (QOL), social-emotional functioning, and behavioral functioning of children treated surgically for craniopharyngiomas.
  • After a mean follow-up period of 6.8 +/- 3.5 years, these 29 patients were administered either the 36-item Short Form Health Survey version 2 or the Child Health Questionnaire-Parent Form to assess QOL, as well as the Achenbach Child Behavior Checklist or Young Adult Checklist to measure social-emotional and behavioral functioning.
  • Further analyses indicated that retrochiasmatic tumor location, recurrence, and additional surgery were associated with poorer outcomes.
  • In contrast, hydrocephalus, tumor size, and sex were not prognostic variables, and patients significantly improved as post-operative time increased.
  • CONCLUSIONS: Attention toward late effects arising after the treatment of pediatric craniopharyngioma, including decreased postoperative physical health and behavioral functioning, is warranted.
  • Future approaches to treatment should consider the documented effects of either gross-total resection or limited surgery followed by cranial irradiation on QOL, with specific evaluation for those with retrochiasmatic tumors, a recurrent tumor, or the need for additional surgery.
  • [MeSH-major] Child Behavior. Craniopharyngioma / surgery. Pituitary Neoplasms / surgery. Quality of Life. Social Behavior
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Humans. Male. Postoperative Complications

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  • [CommentIn] J Neurosurg. 2005 Oct;103(4 Suppl):297-8; discussion 298 [16270679.001]
  • (PMID = 16270681.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Sun HI, Akgun E, Bicer A, Ozkan A, Bozkurt SU, Kurtkaya O, Koc DY, Pamir MN, Kilic T: Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence. Neurosurgery; 2010 Apr;66(4):744-50; discussion 750
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  • [Title] Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence.
  • BACKGROUND: The primary treatment for craniopharyngiomas is total excision, but recurrence is common.
  • OBJECTIVE: We hypothesized that recurrence is linked to the angiogenesis of the tumor.
  • Recurrent and nonrecurrent tumor samples were compared with regard to expression of angiogenesis-related factors and angiogenic capacity in a corneal angiogenesis model.
  • METHODS: Specimens of 4 recurrent and 6 nonrecurrent tumors were selected from 57 patients with adamantinomatous craniopharyngiomas.
  • Expression levels were graded using a 4-point scoring system and were compared.
  • CONCLUSION: These findings suggest a relationship between recurrence of craniopharyngiomas and angiogenesis.
  • New treatment modalities with selective PDGFR-alpha blockers may represent a novel and effective therapeutic option for the treatment of craniopharyngiomas.
  • [MeSH-major] Angiogenesis Inducing Agents / metabolism. Craniopharyngioma / metabolism. Gene Expression Regulation, Neoplastic / physiology. Neoplasm Recurrence, Local / metabolism. Pituitary Neoplasms / metabolism
  • [MeSH-minor] Adult. Animals. Cornea / metabolism. Cornea / pathology. Disease Models, Animal. Female. Fibroblast Growth Factor 2 / metabolism. Fibronectins / metabolism. Humans. Male. Middle Aged. Neoplasm Transplantation. Platelet-Derived Growth Factor / metabolism. Rats. Rats, Sprague-Dawley. Retrospective Studies. Statistics, Nonparametric. Time Factors. Vascular Endothelial Growth Factor A / metabolism. Young Adult

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  • (PMID = 20190664.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Fibronectins; 0 / Platelet-Derived Growth Factor; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
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86. Siemons W, Wilms G, Theys T: Optic tract edema sign and craniopharyngiomas. JBR-BTR; 2010 Jan-Feb;93(1):28-9
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  • [Title] Optic tract edema sign and craniopharyngiomas.
  • Two patients with craniopharyngioma presenting with the "optic tract edema sign" are described.
  • This sign is seen in a majority of craniopharyngiomas and can be of help in the differentiation with other suprasellar masses such as pituitary adenomas, meningiomas, germinomas and lymphomas.
  • [MeSH-major] Craniopharyngioma / pathology. Edema / pathology. Magnetic Resonance Imaging / methods. Pituitary Neoplasms / pathology. Visual Pathways / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Pituitary Gland / pathology. Pituitary Gland / surgery

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  • (PMID = 20397431.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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87. Guo CJ, Wang YC, Zhou ZH, Zhu JX, Li ZM, Guo CL: [Curative effect of stereotactic 186Re endocavitary irradiation on cystic craniopharyngioma]. Zhonghua Zhong Liu Za Zhi; 2010 Jul;32(7):548-50
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  • [Title] [Curative effect of stereotactic 186Re endocavitary irradiation on cystic craniopharyngioma].
  • OBJECTIVE: To evaluate the treatment results of stereotactic (186)Re intracavitary irradiation in the patients with craniopharyngioma.
  • The mean volume of the cystic portion of the tumor before irradiation was 8390 mm(3).
  • CONCLUSION: Stereotactic (186)Re endocavitary irradiation for the treatment of cystic craniopharyngioma is a safe and effective procedure.
  • [MeSH-major] Brachytherapy / methods. Craniopharyngioma / radiotherapy. Pituitary Neoplasms / radiotherapy. Radioisotopes / therapeutic use. Rhenium / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Cysts / radiotherapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Stereotaxic Techniques. Treatment Outcome. Young Adult

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  • (PMID = 21029702.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Radioisotopes; 7440-15-5 / Rhenium
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88. Elliott RE, Hsieh K, Hochm T, Belitskaya-Levy I, Wisoff J, Wisoff JH: Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children. J Neurosurg Pediatr; 2010 Jan;5(1):30-48
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  • [Title] Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children.
  • OBJECT: Optimal treatment of primary and recurrent craniopharyngiomas remains controversial.
  • The authors report their experience with radical resection of both primary and recurrent craniopharyngiomas in children and compare the outcomes between the 2 groups.
  • METHODS: A retrospective analysis was performed in 86 children younger than 21 years of age who underwent a total of 103 operations for craniopharyngioma between 1986 and 2008; these were performed by the senior author.
  • Tumor recurred after GTR in 14 (20%) of 71 patients.
  • Factors negatively affecting overall survival and progression-free survival include subtotal resection (recurrent tumors only), tumor size >or= 5 cm, or presence of hydrocephalus or a ventriculoperitoneal shunt.
  • Prior radiation therapy and increasing tumor size were both risk factors for incomplete resection at reoperation.
  • CONCLUSIONS: In the hands of surgeons with experience with craniopharyngiomas, the authors believe that radical resection at presentation offers the best chance of disease control and potential cure with acceptable morbidity.
  • While GTR does not preclude recurrence and is more difficult to achieve in recurrent tumors, especially large and previously irradiated tumors, radical resection is still possible in patients with recurrent craniopharyngiomas with morbidity similar to that of primary tumors.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Microsurgery / methods. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery
  • [MeSH-minor] Adolescent. Adult. Body Mass Index. Child. Child, Preschool. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Hypopituitarism / diagnosis. Hypopituitarism / etiology. Hypothalamic Diseases / diagnosis. Hypothalamic Diseases / etiology. Infant. Kaplan-Meier Estimate. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Neurologic Examination. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Prognosis. Retrospective Studies. Risk Factors. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • [CommentIn] J Neurosurg Pediatr. 2010 Jan;5(1):27-8; discussion 28-9 [20043734.001]
  • (PMID = 20043735.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Rudnick EF, DiNardo LJ: Image-guided endoscopic endonasal resection of a recurrent craniopharyngioma. Am J Otolaryngol; 2006 Jul-Aug;27(4):266-7
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  • [Title] Image-guided endoscopic endonasal resection of a recurrent craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / surgery. Endoscopy. Neoplasm Recurrence, Local / surgery. Otorhinolaryngologic Surgical Procedures. Pituitary Neoplasms / surgery. Surgery, Computer-Assisted
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 16798405.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Jane JA Jr: Management of pediatric sellar tumors. Pediatr Endocrinol Rev; 2008 Feb;5 Suppl 2:720-6
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  • Craniopharyngiomas and pituitary adenomas are the most common forms of sellar tumors in children.
  • First-line treatment usually consists of surgical resection of the tumor, although dopamine agonist therapy may be considered as first-line therapy in most patients with prolactin-secreting adenomas.
  • Transsphenoidal resection has become increasingly widespread and represents the mainstay of surgical therapy for pituitary adenomas and selected craniopharyngiomas.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / epidemiology. Adenoma / therapy. Adolescent. Adult. Child. Craniopharyngioma / diagnosis. Craniopharyngioma / epidemiology. Craniopharyngioma / therapy. Female. Human Growth Hormone / secretion. Humans. Male. Pituitary ACTH Hypersecretion / therapy. Prolactinoma / therapy. Radiosurgery. Radiotherapy. Surgical Procedures, Operative / methods

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  • (PMID = 18317443.001).
  • [ISSN] 1565-4753
  • [Journal-full-title] Pediatric endocrinology reviews : PER
  • [ISO-abbreviation] Pediatr Endocrinol Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Israel
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
  • [Number-of-references] 57
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91. Kendall-Taylor P, Jönsson PJ, Abs R, Erfurth EM, Koltowska-Häggström M, Price DA, Verhelst J: The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma. Eur J Endocrinol; 2005 Apr;152(4):557-67
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  • [Title] The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma.
  • BACKGROUND: Craniopharyngioma is a parasellar tumour that, although benign, tends to behave aggressively.
  • OBJECTIVES: To investigate the frequency and severity of problems associated with craniopharyngioma, using the large international database (KIMS) for adult patients with GH deficiency (GHD), and to assess the differences between the adult onset (AO, aged 18 or above) disease and adults with childhood onset (CO) craniopharyngioma.
  • DESIGN: Inclusion criteria were: an established diagnosis of craniopharyngioma, severe GHD and no recent GH treatment.
  • RESULTS: Peak age at onset of craniopharyngioma was 15-20 years.
  • Quality of life, assessed by Quality of Life-Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) and the Nottingham Health Profile, was markedly reduced in all groups with no significant differences between them; the QoL-AGHDA score correlated with age at onset of both craniopharyngioma and GHD, and also with BMI in AO patients.
  • CONCLUSIONS: These data emphasise the generally poor state of health of patients treated for craniopharyngioma, with respect to endocrine and metabolic function, and also the markedly reduced quality of life.
  • Adults with CO craniopharyngioma were shorter, had lower IGF-I, lower BMI, less obesity and slightly lower blood lipid levels than patients with AO craniopharyngioma.

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  • (PMID = 15817911.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lipids; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I
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92. Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnrübl F, Hahnen E, Kreutzer J, Fahlbusch R: Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathol; 2005 Jun;109(6):589-97
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  • [Title] Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region.
  • Here, we examined beta-catenin and adenomatous polyposis coli (APC) by mutational analysis in pituitary adenomas (n=60) and a large series of craniopharyngiomas (n=41).
  • Furthermore, the expression pattern of beta-catenin was immunohistochemically analysed in a cohort of tumours and cysts of the sellar region including pituitary adenomas (n=58), craniopharyngiomas (n=57), arachnoidal cysts (n=8), Rathke's cleft cysts (n=10) and xanthogranulomas (n=6).
  • Whereas APC mutations were not detectable in any tumour entity, beta-catenin mutations were present in 77% of craniopharyngiomas, exclusively of the adamantinomatous subtype.
  • We conclude that beta-catenin mutations and/or nuclear accumulation serve as diagnostic hallmarks of the adamantinomatous variant, setting it apart from the papillary variant of craniopharyngioma.
  • [MeSH-major] Craniopharyngioma / genetics. Cytoskeletal Proteins / genetics. Genes, APC. Pituitary Neoplasms / genetics. Sella Turcica / pathology. Trans-Activators / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Child. Child, Preschool. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mutation. Polymorphism, Single-Stranded Conformational. Reverse Transcriptase Polymerase Chain Reaction. beta Catenin

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  • (PMID = 15891929.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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93. Daneshbod Y, Monabati A, Kumar PV, Taghipoor M, Bedayat GR: Intraoperative cytologic crush preparation findings in craniopharyngioma: a study of 72 cases. Acta Cytol; 2005 Jan-Feb;49(1):7-10
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  • [Title] Intraoperative cytologic crush preparation findings in craniopharyngioma: a study of 72 cases.
  • OBJECTIVE: To describe the intraoperative crush preparation and the cytologic features of craniopharyngioma and the differential diagnosis.
  • STUDY DESIGN: Twelve cases of craniopharyngioma were diagnosed by crush preparation cytology in the Department of Pathology, Shiraz Medical School, and formed the basis of this study.
  • The smears were diagnosed as suggestive of craniopharyngioma.
  • CONCLUSION: Intraoperative cytologic crush preparation findings are helpful in the diagnosis of craniopharyngioma, when combined with clinical information.
  • Crush preparation cytology is important in the diagnosis of central nervous system tumors.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Cytodiagnosis. Diagnosis, Differential. Female. Humans. Male. Staining and Labeling / methods

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  • (PMID = 15717747.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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94. Tabaee A, Anand VK, Brown SM, Lin JW, Schwartz TH: Algorithm for reconstruction after endoscopic pituitary and skull base surgery. Laryngoscope; 2007 Jul;117(7):1133-7
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  • STUDY DESIGN AND METHODS: Patients undergoing endoscopic skull base surgery underwent an algorithmic approach to reconstruction based on tumor location, defect size, and presence of intraoperative cerebrospinal fluid (CSF) leak.
  • RESULTS: The diagnosis in the 127 patients in this series included pituitary tumor in 70 (55%) patients, encephalocele in 16 (12.6%) patients, meningioma in 11 (8.7%) patients, craniopharyngioma in 9 (7.1%) patients, and chordoma in 6 (4.7%) patients.
  • [MeSH-major] Adenoma / surgery. Algorithms. Central Nervous System Cysts / surgery. Endoscopy / methods. Meningeal Neoplasms / surgery. Pituitary Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cerebrospinal Fluid Rhinorrhea / etiology. Encephalocele / etiology. Female. Humans. Male. Middle Aged. Postoperative Complications. Prospective Studies. Risk Factors


95. Nyquist GG, Anand VK, Singh A, Schwartz TH: Janus flap: bilateral nasoseptal flaps for anterior skull base reconstruction. Otolaryngol Head Neck Surg; 2010 Mar;142(3):327-31
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  • Pathologies consisted of two pituitary macroadenomas, one planum sphenoidale meningioma, one craniopharyngioma, and one cavernous sinus hemangioma.
  • [MeSH-minor] Adult. Aged. Cavernous Sinus. Cerebrospinal Fluid Otorrhea / prevention & control. Craniopharyngioma / surgery. Endoscopy. Female. Hemangioma / surgery. Humans. Male. Meningioma / surgery. Middle Aged. Nasal Cavity. Postoperative Complications / prevention & control. Prospective Studies. Tissue and Organ Harvesting

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20172375.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Caceres A, Reitman AJ, Tomita T: Craniopharyngioma and Cushing disease: case report. J Neurosurg; 2005 Apr;102(3 Suppl):318-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniopharyngioma and Cushing disease: case report.
  • Craniopharyngioma is a common sellar region tumor occurring in children.
  • Patients with craniopharyngioma commonly present with visual deficits and hydrocephalus.
  • The authors present the case of a child who presented with short stature and clinical evidence of Cushing disease (CD) associated with a suprasellar tumor.
  • The patient underwent insertion of an Ommaya reservoir into the tumor's cystic portion.
  • After adequate decompression of the tumor, the patient underwent total resection.
  • The tumor pathology was compatible with an adamantinomatous craniopharyngioma and immunohistochemical studies failed to show staining for ACTH.
  • [MeSH-major] Central Nervous System Cysts / surgery. Craniopharyngioma / surgery. Pituitary ACTH Hypersecretion / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adrenocorticotropic Hormone / blood. Adult. Child. Cyst Fluid / chemistry. Diagnosis, Differential. Dwarfism, Pituitary / etiology. Follow-Up Studies. Hemianopsia / etiology. Humans. Hypophysectomy. Hypopituitarism / etiology. Magnetic Resonance Imaging. Male. Obesity / etiology. Postoperative Complications / etiology. Tomography, X-Ray Computed

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  • (PMID = 15881759.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
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97. Hannon MJ, Behan LA, Agha A: Thyrotoxic periodic paralysis due to excessive L-thyroxine replacement in a Caucasian man. Ann Clin Biochem; 2009 Sep;46(Pt 5):423-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we describe the case of a patient with panhypopituitarism due to a craniopharyngioma, who developed thyrotoxic periodic paralysis due to excessive L-thyroxine replacement.
  • [MeSH-minor] Adult. European Continental Ancestry Group. Humans. Male


98. Stienen MN, Cadosch D, Bilz S, Hildebrandt G, Gautschi OP: [Craniopharyngioma--a "geographical malignant" tumour]. Praxis (Bern 1994); 2010 Jul 28;99(15):911-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Craniopharyngioma--a "geographical malignant" tumour].
  • [Transliterated title] Das Kraniopharyngeom--ein "geographisch maligner" Tumor.
  • The craniopharyngioma is a rare dysontogenetic tumour that originates from either scattered cells of the craniopharyngeal duct or from metaplastically mutated anterior pituitary parenchyma cells.
  • Despite being classified as a WHO-Class-I tumour, the histologically benign craniopharyngioma may display an aggressive behaviour.
  • [MeSH-major] Craniopharyngioma / diagnosis. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy. Cranial Irradiation. Diagnosis, Differential. Female. Humans. Hypophysectomy. Magnetic Resonance Imaging. Male. Pituitary Gland / pathology. Practice Guidelines as Topic. Prognosis. Radiosurgery. Tomography, X-Ray Computed

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  • (PMID = 20715005.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 54
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99. Linfante I, Tucci C, Andreone V: Fusiform dilatation of the internal carotid artery after craniopharyngioma resection. Pediatr Neurol; 2008 Aug;39(2):139-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fusiform dilatation of the internal carotid artery after craniopharyngioma resection.
  • [MeSH-minor] Adult. Coronary Angiography / methods. Craniopharyngioma / surgery. Female. Humans. Longitudinal Studies

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  • (PMID = 18639763.001).
  • [ISSN] 0887-8994
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Lipton J, Megerian JT, Kothare SV, Cho YJ, Shanahan T, Chart H, Ferber R, Adler-Golden L, Cohen LE, Czeisler CA, Pomeroy SL: Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. Neurology; 2009 Jul 28;73(4):323-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma.

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  • (PMID = 19636054.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01RR02172
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; JL5DK93RCL / Melatonin
  • [Other-IDs] NLM/ PMC2715212
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