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Items 1 to 61 of about 61
1. Lee SH, Park BJ, Kim EJ, Lim YJ: Atypical choroid plexus papilloma in an adult. J Korean Neurosurg Soc; 2009 Jul;46(1):74-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical choroid plexus papilloma in an adult.
  • We present an extremely rare case of the atypical choroid plexus papilloma in an adult which developed at the trigone of right lateral ventricle.
  • The brain magnetic resonance image showed highly enhanced and well demarcated mass at the trigone of lateral ventricle attached to the choroid plexus.
  • The tumor was diagnosed as an atypical choroid plexus papilloma.
  • We report a case of atypical choroid plexus papilloma in adult and introduce newly classified pathologic characteristics of this tumor.

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  • [Cites] J Neurosurg. 2007 Sep;107(3 Suppl):199-202 [17918524.001]
  • [Cites] Acta Neuropathol. 2007 Aug;114(2):97-109 [17618441.001]
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  • (PMID = 19707500.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2729831
  • [Keywords] NOTNLM ; Atypical choroid plexus papilloma / Diffusion tensor imaging / Lateral ventricle / Neuronavigation
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2. Osada H, Mori K, Yamamoto T, Nakao Y, Wada R, Maeda M: Choroid plexus carcinoma secreting carbohydrate antigen 19-9 in an adult. Case report. Neurol Med Chir (Tokyo); 2006 May;46(5):251-3
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  • [Title] Choroid plexus carcinoma secreting carbohydrate antigen 19-9 in an adult. Case report.
  • A 53-year-old man presented with a choroid plexus carcinoma in the body of the right lateral ventricle manifesting as gait disturbance due to left mild hemiparesis and papilledema.
  • Subtotal removal of the tumor was performed.
  • This second case of choroid plexus carcinoma producing CA19-9 indicates that CA19-9 may be a useful marker of choroid plexus carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. CA-19-9 Antigen / metabolism. Choroid Plexus Neoplasms / metabolism

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  • (PMID = 16723819.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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3. Hasselblatt M, Mertsch S, Koos B, Riesmeier B, Stegemann H, Jeibmann A, Tomm M, Schmitz N, Wrede B, Wolff JE, Zheng W, Paulus W: TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion. Cancer Res; 2009 Mar 15;69(6):2219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion.
  • The pathogenesis of choroid plexus papillomas, intraventricular papillary neoplasms most often occurring sporadically in children and young adults, remains poorly understood.
  • To identify pathways operative in the development of choroid plexus papillomas, gene expression profiles obtained from laser-microdissected human choroid plexus papilloma cells (n = 7) were compared with that of normal choroid plexus epithelial cells laser microdissected from autopsy tissue (n = 8).
  • On DNA microarray data analysis, 53 probe sets were differentially expressed in choroid plexus papilloma tumor cells (>7-fold).
  • Knockdown of Twist1 gene expression in the rat choroid plexus epithelial cell line Z310 significantly reduced proliferation as assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and cell invasion in a Matrigel assay, whereas cell migration was not affected.
  • To conclude, using gene expression profiling, several genes differentially expressed in human choroid plexus papillomas could be identified.
  • Among those, TWIST1 is highly expressed in choroid plexus papillomas and promotes proliferation and invasion.
  • [MeSH-major] Nuclear Proteins / biosynthesis. Papilloma, Choroid Plexus / metabolism. Papilloma, Choroid Plexus / pathology. Twist Transcription Factor / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Animals. Cell Growth Processes / physiology. Cell Movement / physiology. Child. Child, Preschool. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Gene Expression Profiling. Humans. Infant. Infant, Newborn. Male. Microdissection. Middle Aged. Neoplasm Invasiveness. Rats. Young Adult

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  • (PMID = 19276370.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / TWIST1 protein, human; 0 / Twist Transcription Factor
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4. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM: VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol; 2006 Feb;290(2):H560-76
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  • [Title] VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature.
  • Unlike during development, blood vessels in the adult are generally thought not to require VEGF for normal function.
  • However, VEGF is a survival factor for many tumor vessels, and there are clues that some normal blood vessels may also depend on VEGF.
  • In this study, we sought to identify which, if any, vascular beds in adult mice depend on VEGF for survival.
  • In a study of 17 normal organs after VEGF inhibition, we found significant capillary regression in pancreatic islets, thyroid, adrenal cortex, pituitary, choroid plexus, small-intestinal villi, and epididymal adipose tissue.
  • Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature.
  • [MeSH-minor] Animals. Blood Pressure. Carcinoma, Lewis Lung / blood supply. Glucose Tolerance Test. Heart / physiology. Imidazoles. Indazoles / pharmacology. Islets of Langerhans / blood supply. Kidney / physiology. Mice. Mice, Inbred C57BL. Mice, Transgenic. Neoplasm Transplantation. Pancreatic Neoplasms / blood supply. Phenotype. Reference Values. Regeneration. Signal Transduction / drug effects. Signal Transduction / physiology. Vascular Endothelial Growth Factor Receptor-1 / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism

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  • [CommentIn] Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H509-11 [16403945.001]
  • (PMID = 16172168.001).
  • [ISSN] 0363-6135
  • [Journal-full-title] American journal of physiology. Heart and circulatory physiology
  • [ISO-abbreviation] Am. J. Physiol. Heart Circ. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-24136; United States / NHLBI NIH HHS / HL / HL-59157; United States / NCI NIH HHS / CA / P50 CA-90270
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Imidazoles; 0 / Indazoles; 0 / Vascular Endothelial Growth Factor A; C9LVQ0YUXG / axitinib; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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5. Gururangan S, Petros WP, Poussaint TY, Hancock ML, Phillips PC, Friedman HS, Bomgaars L, Blaney SM, Kun LE, Boyett JM: Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). Clin Cancer Res; 2006 Mar 1;12(5):1540-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004).
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Choroid Plexus Neoplasms / blood. Choroid Plexus Neoplasms / cerebrospinal fluid. Choroid Plexus Neoplasms / drug therapy. Cohort Studies. Ependymoma / blood. Ependymoma / cerebrospinal fluid. Ependymoma / drug therapy. Female. Glioma / blood. Glioma / cerebrospinal fluid. Glioma / drug therapy. Humans. Injections, Spinal. Male. Maximum Tolerated Dose. Neuroectodermal Tumors, Primitive / blood. Neuroectodermal Tumors, Primitive / cerebrospinal fluid. Neuroectodermal Tumors, Primitive / drug therapy

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  • (PMID = 16533779.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5 U01 CA081457
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; G1LN9045DK / Busulfan
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6. Beschorner R, Mittelbronn M, Mugler M, Meyermann R, Schittenhelm J: Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors. Histol Histopathol; 2009 12;24(12):1507-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors.
  • BACKGROUND: The Wnt and BMP signaling pathways are involved in the morphogenesis of both gastrointestinal and choroid plexus epithelium.
  • In the intestine, Wnt signaling represses the expression of the tumor suppressor gene CDX2 via SOX9, a transcription factor, which is also expressed in the choroid plexus.
  • Recently, an inverse correlation between CDX2 expression and tumor grade, tumor stage and lymph node metastasis in colorectal adenocarcinomas has been reported.
  • To date, no data exist on expression of CDX2 in normal and neoplastic choroid plexus epithelium.
  • AIM: To investigate CDX2 expression in normal and neoplastic choroid plexus.
  • MATERIALS AND METHODS: Paraffin-embedded samples from 60 normal choroid plexus, including 23 fetal tissue samples and from 65 choroid plexus tumors (47 choroid plexus papillomas WHO grade I, 16 atypical choroid plexus papillomas and 2 choroid plexus carcinomas WHO grade III) were examined by immunohistochemistry.
  • Samples from normal choroid plexus were collected from 45 autopsy cases and from 15 neurosurgical specimens.
  • RESULTS: Normal and neoplastic choroid plexus lacked CDX2 expression.
  • CONCLUSION: In our series, immunohistochemistry shows no evidence for a role of CDX2 in development or differentiation of normal choroid plexus from the 9th gestational week until adulthood.
  • Since choroid plexus tumors reliably lack CDX2 immunoreactivity, this marker may be helpful in distinguishing cerebral metastases from CDX2-positive adenocarcinomas and choroid plexus neoplasms.
  • [MeSH-major] Choroid Plexus / metabolism. Choroid Plexus Neoplasms / metabolism. Homeodomain Proteins / analysis. Homeodomain Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. CDX2 Transcription Factor. Case-Control Studies. Child. Child, Preschool. Epithelium / metabolism. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Young Adult

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  • (PMID = 19795349.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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7. Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M: Malignant progression in choroid plexus papillomas. J Neurosurg; 2007 Sep;107(3 Suppl):199-202

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant progression in choroid plexus papillomas.
  • OBJECT: Malignant progression of choroid plexus papillomas has been occasionally reported, but this issue has not yet been systematically addressed.
  • METHODS: Frequency and extent of malignant progression were examined in a retrospective series of 124 primary choroid plexus papillomas using uniform histological criteria.
  • RESULTS: After gross-total resection and a mean follow-up period of 59 months, 12 recurrences necessitating neurosurgical intervention had occurred in the 103 cases of choroid plexus papilloma (World Health Organization [WHO] Grade I) and 21 cases of atypical choroid plexus papilloma (WHO Grade II).
  • The proportion of recurring tumors was higher in cases of atypical choroid plexus papilloma than in cases of choroid plexus papilloma (six [29%] of 21 compared with six [6%] of 103, respectively; p < 0.05).
  • In the majority (10 of 12) of the recurrences, there was a close correspondence between the primary tumor and the recurrence with respect to features identified on routine histological examination as well as Ki 67 (MIB-1) proliferation indices (median value 4% for both primary and recurrent tumors; range 0-15% for primary compared with 0-12% for recurrent tumors).
  • However, two patients experienced a transition from a choroid plexus papilloma (WHO Grade I) and an atypical choroid plexus papilloma (WHO Grade II) to choroid plexus carcinomas (WHO Grade III).
  • CONCLUSIONS: Recurrent tumor growth after gross-total resection is rare in choroid plexus papillomas, but malignant progression to choroid plexus carcinoma does occur in a small percentage of tumors.
  • [MeSH-major] Carcinoma / pathology. Choroid Plexus / pathology. Papilloma, Choroid Plexus / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies

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  • (PMID = 17918524.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Ortega-Martínez M, Cabezudo-Artero JM, Fernández-Portales I, Pimentel JJ, Gómez de Tejada R: Diffuse leptomeningeal seeding from benign choroid plexus papilloma. Acta Neurochir (Wien); 2007 Dec;149(12):1229-36; discussion 1236-7
Genetic Alliance. consumer health - Choroid Plexus Papilloma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffuse leptomeningeal seeding from benign choroid plexus papilloma.
  • Choroid plexus papillomas (CPP) are rare intracranial tumours with a favourable long-term outcome after surgical excision.
  • We report an unusual example of a fourth ventricle choroid plexus papilloma with diffuse leptomeningeal seeding.
  • We review the literature concerning leptomeningeal dissemination of benign choroid plexus papillomas.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Fourth Ventricle / surgery. Meningeal Neoplasms / secondary. Neoplasm Seeding. Papilloma, Choroid Plexus / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Disease Progression. Fatal Outcome. Female. Humans. Ki-67 Antigen / analysis. Laminectomy. Magnetic Resonance Imaging. Meninges / pathology. Reoperation. S100 Proteins / analysis

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  • (PMID = 17924056.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / S100 Proteins
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9. Cecchi PC, Billio A, Colombetti V, Rizzo P, Ricci UM, Schwarz A: Primary high-grade B-cell lymphoma of the choroid plexus. Clin Neurol Neurosurg; 2008 Jan;110(1):75-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary high-grade B-cell lymphoma of the choroid plexus.
  • Amongst the primary ventricular forms occasionally reported, a choroid plexus origin is extremely rare; to date, only three cases have been described in the English literature.
  • She underwent a parieto-occipital craniotomy and a navigation-assisted posterior parietal transcortical approach, achieving complete removal of the intraventricular lesion originating from the choroid plexus.
  • Primary choroid plexus lymphoma is a very rare tumor that should be included in the differential diagnosis of intraventricular neoplasms.
  • It usually occurs in the lateral ventricles (with a predilection for the atrium) of adult people (>50 years of age), apparently with a male prevalence.
  • [MeSH-major] Choroid Plexus Neoplasms / pathology. Choroid Plexus Neoplasms / surgery. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large B-Cell, Diffuse / surgery

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  • (PMID = 17928135.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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10. Mitsuyama T, Ide M, Hagiwara S, Tanaka N, Kawamura H, Aiba M: [Adult choroid plexus papilloma of the posterior fossa: extraventricular location]. No Shinkei Geka; 2005 Aug;33(8):825-9
Genetic Alliance. consumer health - Choroid Plexus Papilloma.

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  • [Title] [Adult choroid plexus papilloma of the posterior fossa: extraventricular location].
  • Choroid plexus papillomas (CPPs) are rare neuroectodermal neoplasms accounting for 0.4% of all intracranial neoplasms in adults.
  • It is difficult to diagnose CPP preoperatively when the main portion of the tumor is not located in the 4th ventricle.
  • Magnetic resonance imaging demonstrated an intracerebellar solid tumor with multilocular cysts, extending towards both the right lateral medullary region and the foramen of Luschka.
  • Angiographically, via the right posterior inferior cerebellar artery revealed the tumor was faintly opacified.
  • Tumor was subtotally resected through a right suboccipital craniectomy.
  • CPP should be considered among calcified and enhanced masses in the lateral medullary to cerebellopontine angle space in adults, even if the main portion of the tumor is not located in the 4th ventricle.
  • [MeSH-major] Infratentorial Neoplasms / surgery. Papilloma, Choroid Plexus / surgery

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  • [ErratumIn] No Shinkei Geka. 2005 Oct;33(10):977
  • (PMID = 16095214.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Cabrera-Socorro A, Pueyo Morlans M, Suarez Sola ML, Gonzalez Delgado FJ, Castañeyra-Perdomo A, Marin MC, Meyer G: Multiple isoforms of the tumor protein p73 are expressed in the adult human telencephalon and choroid plexus and present in the cerebrospinal fluid. Eur J Neurosci; 2006 Apr;23(8):2109-18
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  • [Title] Multiple isoforms of the tumor protein p73 are expressed in the adult human telencephalon and choroid plexus and present in the cerebrospinal fluid.
  • p73, a homolog of the p53 tumor suppressor, codes for full-length transactivating (TA) and N-terminally truncated (DeltaN) isoforms, with pro- and anti-apoptotic activities, respectively.
  • We examined the expression of the main p73 isoforms in adult human and mouse telencephalon and choroid plexus by immunohistochemistry on paraffin sections, and immunoblotting (IB) of tissue extracts and cerebrospinal fluid (CSF), using antibodies against different protein domains.
  • IB showed an array of TAp73 variants in adult human cortex and hippocampus.
  • IB of human choroid plexus and CSF using TAp73-specific antibodies revealed the presence of a approximately 90-kDa protein whose molecular weight was reduced after N-deglycosylation, suggesting that glycosylated TAp73 is exported into the CSF.
  • In the mouse, high expression of TAp73 was also detected in the subcommissural organ (SCO), an ependymal gland absent in adult humans.
  • TAp73 colocalized with anti-fibra-Reissner-antibody (AFRU), which is a marker of Reissner's fiber, the secreted SCO product. p73-deficient mice had generalized cortical hypoplasia and hydrocephalus; in addition, we observed a dramatic size reduction of the choroid plexus.
  • Our findings point to complex and widespread p73 activities in the maintenance of adult cortical neurons and in brain homeostasis.
  • TAp73 in the CSF may play important roles in the maintenance of the adult ventricular wall as well as in the development of the proliferating neuroepithelium.
  • [MeSH-major] Choroid Plexus / metabolism. DNA-Binding Proteins / metabolism. Gene Expression / physiology. Nuclear Proteins / metabolism. Telencephalon / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Animals. Blotting, Western / methods. Cell Adhesion Molecules, Neuronal / metabolism. Cell Line. Female. Genes, Tumor Suppressor. Humans. Immunohistochemistry / methods. Immunoprecipitation / methods. Male. Mice. Mice, Knockout. Middle Aged. Molecular Weight. Mutagenesis / physiology. Protein Isoforms / genetics. Protein Isoforms / metabolism. Transfection / methods. Tumor Suppressor Proteins

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  • (PMID = 16630058.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules, Neuronal; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Protein Isoforms; 0 / SCO-spondin; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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12. Tanaka K, Sasayama T, Nishihara M, Sakagami Y, Kondoh T, Ohbayashi C, Kohmura E: Rapid regrowth of an atypical choroid plexus papilloma located in the cerebellopontine angle. J Clin Neurosci; 2009 Jan;16(1):121-4
Genetic Alliance. consumer health - Choroid Plexus Papilloma.

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  • [Title] Rapid regrowth of an atypical choroid plexus papilloma located in the cerebellopontine angle.
  • Choroid plexus papilloma usually occurs in the lateral or the fourth ventricle.
  • Primary choroid plexus papilloma of the cerebellopontine angle, as described here, is an uncommon lesion.
  • CT scans and MRI showed a large extra-axial tumor in the right cerebellopontine angle.
  • Pathological study revealed that the lesion was choroid plexus papilloma.
  • Repeat imaging conducted 1 year after the operation showed that the tumor had recurred with distinct cystic features.
  • Pathological examination again revealed increased mitotic activity and supported a diagnosis of atypical choroid plexus papilloma.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Cerebellopontine Angle / pathology. Choroid Plexus Neoplasms / pathology. Papilloma, Choroid Plexus / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Radiotherapy

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  • (PMID = 19008101.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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13. Lozier AP, Arbaje YM, Scheithauer BW: Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report. Neurosurgery; 2009 Oct;65(4):E816-7
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  • [Title] Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report.
  • OBJECTIVE: Choroid plexus carcinoma (CPCa) is an uncommon tumor rarely occurring in patients older than 2 years of age.
  • The case reported herein represents the first documented example of a primary supratentorial, extraventricular CPCa in an adult.
  • INTERVENTION: The tumor was gross-totally removed via a frontotemporal craniotomy.
  • A magnetic resonance imaging scan 44 months after surgery showed no evidence of residual or recurrent tumor.
  • [MeSH-major] Carcinoma / pathology. Choroid Plexus / pathology. Choroid Plexus Neoplasms / pathology

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  • (PMID = 19834361.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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14. Beschorner R, Pantazis G, Jeibmann A, Boy J, Meyermann R, Mittelbronn M, Schittenhelm J: Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium. Acta Neuropathol; 2009 Jun;117(6):667-75
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  • [Title] Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium.
  • Microscopic distinction of normal choroid plexus (CP) from choroid plexus tumors (CPT) may be difficult, especially in small samples of well-differentiated CP papillomas.
  • Recently, a correlation between expression/function of glial glutamate transporters EAAT-1 (GLAST) and EAAT-2 (Glt-1) and tumor proliferation has been reported.
  • Tissue of normal CP was obtained from 50 autopsy cases (20 normal and 30 pathologic brains) and 18 neurosurgical specimens that included 17 fetal, 21 pediatric and 30 adult cases.
  • In CPT, expression of EAAT-1 was found in 64 of 79 (81%) tumor samples and was significantly age-dependent (P < 0.0001).
  • GFAP expression was found in 3 of 32 (10%) normal CP and in 28 of 73 (38%) tumor samples.
  • [MeSH-major] Choroid Plexus / metabolism. Choroid Plexus / physiology. Choroid Plexus Neoplasms / metabolism. Excitatory Amino Acid Transporter 1 / metabolism
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Epithelium / embryology. Epithelium / metabolism. Female. Glial Fibrillary Acidic Protein / metabolism. Glutamate Plasma Membrane Transport Proteins / metabolism. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Middle Aged. Young Adult

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  • (PMID = 19283393.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Transporter 1; 0 / Glial Fibrillary Acidic Protein; 0 / Glutamate Plasma Membrane Transport Proteins; 0 / SLC1A2 protein, human; 0 / SLC1A3 protein, human
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15. Jeibmann A, Hasselblatt M, Gerss J, Wrede B, Egensperger R, Beschorner R, Hans VH, Rickert CH, Wolff JE, Paulus W: Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol; 2006 Nov;65(11):1069-73
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  • [Title] Prognostic implications of atypical histologic features in choroid plexus papilloma.
  • The prognostic significance of atypical histologic features in choroid plexus tumors remains uncertain.
  • Therefore, a series of 164 choroid plexus tumors was evaluated for the presence of atypical histologic features, including mitotic activity, increased cellularity, nuclear pleomorphism, blurring of papillary growth pattern, and necrosis.
  • Twenty-four tumors displaying frank signs of malignancy were diagnosed as choroid plexus carcinoma according to World Health Organization criteria.
  • Of 124 choroid plexus papillomas that had not received adjuvant treatment, 46 tumors (37%) displayed at least one atypical feature, including increased cellularity (n = 25 [20%]), mitotic activity (> or =2 mitoses per 10 high-power fields; n = 19 [15%]), nuclear pleomorphism (n = 16 [13%]), solid growth (n = 15 [12%]), and necrosis (n = 5 [4%]).
  • Only one tumor-related death, but 10 recurrences, were observed on a mean observation time of 58 months.
  • Because mitotic activity is the sole atypical histologic feature independently associated with recurrence, we propose to define atypical choroid plexus papilloma by mitotic activity (> or =2 mitoses per 10 high-power fields) corresponding to World Health Organization grade II, thus adjoining other intermediate tumor entities associated with increased mitotic activity such as atypical meningioma.
  • Close follow up of patients harboring atypical choroid plexus papillomas may be warranted.
  • [MeSH-major] Papilloma, Choroid Plexus / classification. Papilloma, Choroid Plexus / pathology
  • [MeSH-minor] Adult. Child. Child, Preschool. Disease-Free Survival. Female. History, 15th Century. Humans. Infant. Male. Mitotic Index. Necrosis / pathology. Neoplasm Recurrence, Local / pathology. Prognosis. Survival Analysis. World Health Organization

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  • (PMID = 17086103.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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16. Losi-Guembarovski R, Kuasne H, Guembarovski AL, Rainho CA, Cólus IM: DNA methylation patterns of the CDH1, RARB, and SFN genes in choroid plexus tumors. Cancer Genet Cytogenet; 2007 Dec;179(2):140-5
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  • [Title] DNA methylation patterns of the CDH1, RARB, and SFN genes in choroid plexus tumors.
  • Genetic and epigenetic alterations in choroid plexus tumors, a rare neuroepithelial neoplasm most frequently detected in children, are poorly characterized.
  • Epigenetic silencing associated with aberrant CpG island methylation is one mechanism leading to the loss of tumor suppressor functions in cancer cells.
  • Using methylation-specific polymerase chain reaction, the methylation patterns of the genes CDH1 (E-cadherin), RARB (retinoic acid receptor, beta), and SFN (stratifin; 14-3-3sigma) were retrospectively investigated in eight choroid plexus tumors (five papillomas, two atypical papillomas, and one carcinoma), as well as in two normal cortexes obtained after autopsy from male individuals aged 6 months and 64 years.
  • Among the six pediatric tumors, the mean age at diagnosis was 1.8 years old (range, 0.2-6) and the two adult tumors were detected in a 66-year-old man and a 45-year-old woman.
  • Tumor-specific RARB hypermethylation was observed in four papillomas.
  • Further studies are required to evaluate the role of aberrant methylation in choroid plexus tumor progression.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cadherins / genetics. Choroid Plexus Neoplasms / genetics. DNA Methylation. Exonucleases / genetics. Neoplasm Proteins / genetics. Receptors, Retinoic Acid / genetics
  • [MeSH-minor] 14-3-3 Proteins. Aged. Carcinoma / genetics. Child. Child, Preschool. Choroid Plexus / metabolism. Exoribonucleases. Female. Humans. Infant. Male. Middle Aged. Papilloma / genetics. Retrospective Studies

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  • (PMID = 18036402.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / CDH1 protein, human; 0 / Cadherins; 0 / Neoplasm Proteins; 0 / Receptors, Retinoic Acid; 0 / retinoic acid receptor beta; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human
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17. Tena-Suck ML, Salinas-Lara C, Rembao-Bojórquez D, Castillejos M: Clinicopathologic and immunohistochemical study of choroid plexus tumors: single-institution experience in Mexican population. J Neurooncol; 2010 Jul;98(3):357-65
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  • [Title] Clinicopathologic and immunohistochemical study of choroid plexus tumors: single-institution experience in Mexican population.
  • In recent years, few studies have specifically focused on only histological features in choroid plexus tumors.
  • We retrospectively reviewed the clinicopathologic and histological features in 37 patients with choroid plexus tumors and correlated these with glial fibrillary acidic protein (GFAP) expression and proliferation cell nuclear antigen (PCNA), p53, p21, and Rb labeling indexes, with special attention to tumor recurrence/regrowth.
  • The study included 24 choroid plexus papillomas (CPPs), 4 atypical choroid plexus papillomas (ACPPs), and 9 choroid plexus carcinomas (CPCs).
  • Most of the choroid plexus tumors were located in the IV ventricle.
  • [MeSH-major] Carcinoma / metabolism. Carcinoma / pathology. Choroid Plexus Neoplasms / metabolism. Choroid Plexus Neoplasms / pathology. Papilloma, Choroid Plexus / metabolism. Papilloma, Choroid Plexus / pathology
  • [MeSH-minor] Adolescent. Adult. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / metabolism. Humans. Kaplan-Meier Estimate. Male. Mexico / epidemiology. Middle Aged. Proliferating Cell Nuclear Antigen / metabolism. Retinoblastoma Protein / metabolism. Retrospective Studies. Tumor Suppressor Protein p53 / metabolism. Young Adult

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  • (PMID = 20082118.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Glial Fibrillary Acidic Protein; 0 / Proliferating Cell Nuclear Antigen; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53
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18. Kim IY, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD: Gamma knife radiosurgery for treatment resistant choroid plexus papillomas. J Neurooncol; 2008 Oct;90(1):105-10
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  • [Title] Gamma knife radiosurgery for treatment resistant choroid plexus papillomas.
  • OBJECTIVE: To report the results of gamma knife radiosurgery (GKR) for treatment resistant choroid plexus papillomas.
  • METHODS: Six patients (median age 55 years; range 29-75) with residual (n = 2) or recurrent (n = 4) choroid plexus papillomas underwent GKR.
  • The median and mean tumor volumes were 2.7 and 3.9 cc (range, 0.23-21.1).
  • A median margin dose of 12.0 Gy (range, 11.5-15) was prescribed to the tumor margin.
  • At the second GKR, the tumor volume varied from 1.3 to 12.4 cc, and the marginal radiation dose varied from 11 to 14 Gy.
  • It may especially be useful for patients with small deep seated residual choroid plexus papillomas, and for tumors that recur at a site distant from their origin.
  • [MeSH-major] Brain Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Papilloma, Choroid Plexus / surgery
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiosurgery

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  • (PMID = 18587534.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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19. Hasselblatt M, Böhm C, Tatenhorst L, Dinh V, Newrzella D, Keyvani K, Jeibmann A, Buerger H, Rickert CH, Paulus W: Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Am J Surg Pathol; 2006 Jan;30(1):66-74
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  • [Title] Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach.
  • To identify specific markers for the diagnosis of choroid plexus tumors, gene expression profiles of choroid plexus epithelial cells (n = 8) and ependymal cells (n = 6) microdissected from human autopsy brains as well as choroid plexus papilloma tissue were investigated using DNA microarrays.
  • Protein expression of genes overexpressed in choroid plexus was evaluated in normal choroid plexus, choroid plexus papilloma, choroid plexus carcinoma, other primary brain tumors, and cerebral metastases.
  • Forty-six genes found to be overexpressed in normal choroid plexus epithelial cells were also present in choroid plexus papilloma.
  • Expression of inward rectifier potassium channel Kir7.1 was confirmed in normal choroid plexus (34 of 35), choroid plexus papilloma (12 of 18), and choroid plexus carcinoma (5 of 5) but was not found in 100 other primary brain tumors and cerebral metastases.
  • Similarly, stanniocalcin-1 stained normal choroid plexus (32 of 35), choroid plexus papilloma (16 of 18), and choroid plexus carcinoma (3 of 5), whereas staining was seen in only 2 of 100 other primary brain tumors and cerebral metastases.
  • Transthyretin stained choroid plexus (33 of 35), choroid plexus papilloma (14 of 18), and plexus carcinoma (2 of 5), but its specificity was significantly lower.
  • Our data suggest that antibodies directed against Kir7.1 and stanniocalcin-1 might serve as sensitive and specific diagnostic markers for choroid plexus tumors.
  • [MeSH-major] Biomarkers, Tumor / genetics. Choroid Plexus Neoplasms / diagnosis. Papilloma, Choroid Plexus / diagnosis
  • [MeSH-minor] Adult. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Diagnosis, Differential. Ependyma / metabolism. Ependyma / pathology. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Gene Expression. Gene Expression Profiling. Glycoproteins / metabolism. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Potassium Channels, Inwardly Rectifying / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 16330944.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Kir7.1 channel; 0 / Potassium Channels, Inwardly Rectifying; 76687-96-2 / teleocalcin
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20. Kumabe T, Fujimura M, Jokura H, Tominaga T: Surgical treatment for choroid plexus tumors in the fourth ventricle: brain stem infiltration hinders total extirpation. Neurosurg Rev; 2008 Apr;31(2):165-72; discussion 172
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  • [Title] Surgical treatment for choroid plexus tumors in the fourth ventricle: brain stem infiltration hinders total extirpation.
  • The significance of surgery for choroid plexus tumors is well established, but surgical resection of those in the fourth ventricle has not been evaluated.
  • This study reviewed five consecutive patients with choroid plexus tumors in the fourth ventricle treated in our institute between 1996 and 2005, focusing on the factors that hindered total extirpation.
  • Two cases were choroid plexus papillomas, and three cases were choroid plexus carcinomas.
  • All patients with choroid plexus carcinomas underwent radiation therapy after the surgical removal.
  • No patient suffered tumor progression within the follow-up of 24-129 months (mean 64 months).
  • Total resection of choroid plexus tumors in the fourth ventricle is difficult because of invasion into the fourth ventricle floor.
  • Adjuvant therapy for choroid plexus tumors with brain stem infiltration must be established.
  • [MeSH-major] Brain Stem / pathology. Carcinoma / surgery. Cerebral Ventricle Neoplasms / surgery. Choroid Plexus Neoplasms / surgery. Fourth Ventricle / surgery. Neurosurgical Procedures. Papilloma, Choroid Plexus / surgery
  • [MeSH-minor] Adult. Cerebral Hemorrhage / therapy. Child, Preschool. Female. Humans. Intraoperative Complications / therapy. Laminectomy. Magnetic Resonance Imaging. Male. Pregnancy

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  • [Cites] J Neurooncol. 2002 Apr;57(2):123-6 [12125972.001]
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  • (PMID = 17912563.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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21. Michalowski MB, de Fraipont F, Michelland S, Entz-Werle N, Grill J, Pasquier B, Favrot MC, Plantaz D: Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma. Cancer Genet Cytogenet; 2006 Apr 1;166(1):74-81
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  • [Title] Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma.
  • Ependymomas (EP) represent the third most frequent type of central nervous system (CNS) tumor of childhood, after astrocytomas and medulloblastomas.
  • No prognostic biological markers are available, and differentiation from choroid plexus papilloma (CPP) is difficult.
  • Three adult corteses were used as a control.
  • The percentages of TRAIL pathway genes (CASP8, TFRSF10C, and TFRSF10D) methylated were 30, 9.5, and 36.4%, respectively, in ependymomas and 50, 50, and 16.7%, respectively, in choroid plexus papillomas.
  • Although we did not observe a statistical relationship between methylation and clinical outcome, the methylation pattern does not appear to be randomly distributed in ependymoma and may represent a mechanism of tumor development and evolution.
  • [MeSH-major] Apoptosis Regulatory Proteins / genetics. Brain Neoplasms / genetics. DNA Methylation. Ependymoma / genetics. Membrane Glycoproteins / genetics. Papilloma, Choroid Plexus / genetics. Tumor Necrosis Factor-alpha / genetics. Tumor Suppressor Proteins / genetics


22. Mazloom A, Wolff JE, Paulino AC: The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. Int J Radiat Oncol Biol Phys; 2010 Sep 1;78(1):79-84
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  • [Title] The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma.
  • PURPOSE: To perform a comprehensive literature review and analysis of cases dealing with choroid plexus carcinoma (CPC) to determine the optimal radiotherapy (RT) treatment field.
  • The RT treatment volume was the craniospinal axis in 38 (68%), whole brain in 9 (16%), and tumor/tumor bed in 9 (16%).
  • The 5-year PFS for patients who had CSI vs. whole brain and tumor/tumor bed RT were 44.2% and 15.3%.
  • [MeSH-major] Carcinoma / radiotherapy. Choroid Plexus Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Cranial Irradiation / methods. Disease-Free Survival. Humans. Infant. Middle Aged. Neoplasm Recurrence, Local. Survival Rate. Young Adult

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20004534.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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23. Farnedi A, Marucci G, Tosi AL, Magrini E, Pession A: [Choroid plexus tumours: cytogenetic analysis of a single case and literature review]. Pathologica; 2007 Dec;99(6):424-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Choroid plexus tumours: cytogenetic analysis of a single case and literature review].
  • Choroid plexus tumours are intraventricular papillary lesions that are observed in typical papillomas, atypical papillomas and carcinomas.
  • The present paper describes a case of choroid plexus papilloma in an adult woman; cytogenetic analysis of the lesion is also presented, which demonstrated the presence of tumour mosaicism.
  • [MeSH-major] Choroid Plexus Neoplasms / pathology. Papilloma / pathology
  • [MeSH-minor] Adult. Aneuploidy. Antigens, Neoplasm / analysis. Biomarkers, Tumor. Chromosome Aberrations. Female. Humans. Karyotyping. Ki-67 Antigen / analysis. Prognosis

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  • (PMID = 18416333.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
  • [Number-of-references] 10
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24. Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A, Mahajan A, Rutkowski S, Diez B, Wang X, Pietsch T, Kortmann RD, Paulus W, Jeibmann A, Wolff JEA: Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol; 2009 Dec;95(3):383-392
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  • [Title] Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study.
  • Atypical choroid plexus papilloma (APP) represents a novel intermediate-grade subtype of choroid plexus tumor (CPT), the clinical outcome of which has not been described yet.
  • In the treatment group, one patient with a metastasized tumor and incompletely resected APP died.
  • While APP was defined histologically, median percentages of both the Ki-67/MIB-1 proliferation marker and the p53 tumor suppressor protein increased across the three histological subtypes (from CPP to APP and then CPC), suggesting that the subtypes comprise an ordinal categorization of increasingly severe CPT tumors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Choroid Plexus Neoplasms / drug therapy. Choroid Plexus Neoplasms / mortality. Papilloma, Choroid Plexus / drug therapy. Papilloma, Choroid Plexus / mortality
  • [MeSH-minor] Adolescent. Adult. Carboplatin / administration & dosage. Child, Preschool. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Etoposide / administration & dosage. Female. Gadolinium. Humans. Infant. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Registries. Vincristine / administration & dosage. Young Adult

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  • (PMID = 19543851.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00500890
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / R01 CA083932
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; AU0V1LM3JT / Gadolinium; BG3F62OND5 / Carboplatin
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25. Noshita N, Kumabe T, Kayama T, Tominaga T: [Choroid plexus tumors: report of 7 cases in a single institution]. No Shinkei Geka; 2006 Jan;34(1):73-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Choroid plexus tumors: report of 7 cases in a single institution].
  • The management of seven patients with choroid plexus tumors, 4 adults and 3 children (mean age 17.5 years) at our institution was reviewed.
  • Subtotal resection was achieved in four patients, one of whom underwent second surgery resulting in total resection, and one patient died of respiratory disturbance after the third operation because of regrowth of the tumor.
  • [MeSH-major] Choroid Plexus / pathology. Choroid Plexus Neoplasms / diagnosis
  • [MeSH-minor] Adult. Child, Preschool. Female. Humans. Infant. Magnetic Resonance Imaging. Male

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  • (PMID = 16440700.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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26. Jinhu Y, Jianping D, Jun M, Hui S, Yepeng F: Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neurooncol; 2007 May;83(1):47-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature.
  • Cerebrospinal metastases of benign choroid plexus papillomas (CPPs) are extremely rare.
  • Plain CT scan of the cranium revealed a partly calcified tumor filling the fourth ventricle and its right recess.
  • Cranial MRI showed an inhomogeneously contrast-enhancing tumor and leptomeningeal enhancement encasing the brain stem.
  • Complete resection of the tumor was carried out, and seedings to the floor of the fourth ventricle and cervico-medullary junction were found during the operation.
  • While intraoperative frozen section suggested pathology of papillary ependymoma or CPP, to our surprise, final histological examination revealed a benign choroid plexus papilloma.
  • [MeSH-major] Central Nervous System Neoplasms / secondary. Cerebral Ventricle Neoplasms / secondary. Choroid Plexus Neoplasms / pathology. Choroid Plexus Neoplasms / secondary. Fourth Ventricle. Papilloma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Seeding. Neurosurgical Procedures / adverse effects. Subarachnoid Space. Tomography, X-Ray Computed

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  • (PMID = 17387433.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 33
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27. McCall T, Binning M, Blumenthal DT, Jensen RL: Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature. Surg Neurol; 2006 Jul;66(1):62-7; discussion 67-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature.
  • BACKGROUND: Choroid plexus papillomas are typically considered benign lesions, but histology is not always predictive of their behavior.
  • We present 2 cases that illustrate the wide diversity with which choroid plexus papillomas can disseminate.
  • CASE DESCRIPTIONS: The patient described in case 1 had a primary fourth ventricular choroid plexus papilloma that produced diffuse cystic subarachnoid and leptomeningeal lesions.
  • Patient 2 also had a primary fourth ventricular tumor but with subsequent suprasellar and spinal drop metastases.
  • CONCLUSIONS: Variations of choroid plexus papilloma dissemination include intraventricular, subarachnoid, and leptomeningeal nodules or cystic lesions, and intraparenchymal locations.
  • There is no consensus on the most effective treatment for choroid plexus papilloma metastases; surgical resection, chemotherapy, and radiation therapy may all yield benefits.
  • The prognosis for patients with disseminated choroid plexus papilloma can range from prolonged stable disease and symptoms to death within months.
  • [MeSH-major] Choroid Plexus / pathology. Choroid Plexus / surgery. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / therapy. Papilloma, Choroid Plexus / diagnosis. Papilloma, Choroid Plexus / therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Arachnoid / pathology. Arachnoid / physiopathology. Arachnoid / surgery. Disease Progression. Female. Humans. Pia Mater / pathology. Pia Mater / physiopathology. Pia Mater / surgery. Subarachnoid Space / pathology. Subarachnoid Space / physiopathology. Subarachnoid Space / surgery. Treatment Outcome

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  • (PMID = 16793445.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 34
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28. Beschorner R, Schittenhelm J, Schimmel H, Iglesias-Rozas JR, Herberts T, Schlaszus H, Meyermann R, Wehrmann M: Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1. Hum Pathol; 2006 Jul;37(7):854-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1.
  • Tumors of the choroid plexus (CPTs) are rare neoplasms of neuroectodermal origin usually arising in pediatric patients.
  • However, CPT may occur at any age, and their distinction from metastatic carcinomas is often difficult in adult cases.
  • Because CPTs frequently show focal glial differentiation, we now investigated 35 CPTs (19 males and 16 females 0.3-70 years old; median age, 25.0 years), including 21 choroid plexus papillomas (CPPs), 5 atypical CPP, and 9 choroid plexus carcinomas regarding their expression of the excitatory amino acid transporter-1 (EAAT1, corresponding to rodent GLAST/GLAST-1) by immunohistochemistry.
  • Of the 35 CPTs, 23 (66%) showed membranous EAAT1 expression in variable numbers of tumor cells, including all atypical CPP and 3 of 9 choroid plexus carcinomas (33%).
  • Excitatory amino acid transporter-1 expression in CPT was significantly age dependent (P < .0001), with the proportion of EAAT1-positive tumor cells increasing with age, but not sex dependent.
  • Establishing a cutoff value of 1% immunoreactive tumor cells served in adult cases to distinguish CPT from metastatic adenocarcinomas with 100% specificity and 70% sensitivity and was associated with positive and negative predictive values of 100% and 91%, respectively.
  • [MeSH-major] Carcinoma / metabolism. Choroid Plexus Neoplasms / metabolism. Excitatory Amino Acid Transporter 1 / biosynthesis. Glioma / metabolism. Neuroectodermal Tumors / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adolescent. Adult. Age Factors. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Middle Aged. Sex Factors

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  • (PMID = 16784985.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Transporter 1
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29. Hartge DR, Axt-Fliedner R, Weichert J: Prenatal diagnosis and successful postnatal therapy of an atypical choroid plexus papilloma-Case report and review of literature. J Clin Ultrasound; 2010 Sep;38(7):377-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal diagnosis and successful postnatal therapy of an atypical choroid plexus papilloma-Case report and review of literature.
  • This report describes the perinatal management of a prenatally detected choroid plexus papilloma in an otherwise unaltered singleton pregnancy of a healthy woman.
  • After elective Caesarean section, a successful embolization of the feeding vessel followed by a craniotomy and complete removal of the remaining tumor were performed.
  • [MeSH-major] Embolization, Therapeutic / methods. Papilloma, Choroid Plexus / therapy. Papilloma, Choroid Plexus / ultrasonography. Ultrasonography, Doppler, Color / methods. Ultrasonography, Prenatal / methods
  • [MeSH-minor] Adult. Craniotomy / methods. Female. Follow-Up Studies. Humans. Pregnancy

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  • (PMID = 20564313.001).
  • [ISSN] 1097-0096
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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30. Ishiwata I, Ishiwata C, Ishiwata E, Sato Y, Kiguchi K, Tachibana T, Hashimoto H, Ishikawa H: Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP). Hum Cell; 2005 Mar;18(1):67-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP).
  • A cell line designated "HIBSPP" was established from a human malignant choroids plexus papilloma of 29-year-old Japanese woman.
  • The culture cells were easily transplanted into the subcutis of nude mice and produced the tumor resembling the original tumor.
  • [MeSH-major] Choroid Plexus Neoplasms / pathology. Glioma / pathology
  • [MeSH-minor] Adult. Aneuploidy. Animals. Antigens, Neoplasm / analysis. Cell Line, Tumor. Cell Proliferation. Culture Media / chemistry. Female. Humans. Karyotyping. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Transplantation. Time Factors

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  • (PMID = 16130902.001).
  • [ISSN] 0914-7470
  • [Journal-full-title] Human cell
  • [ISO-abbreviation] Hum. Cell
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Culture Media
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31. Messing-Jünger AM, Riemenschneider MJ, Reifenberger G: A 21-year-old female with a third ventricular tumor. Brain Pathol; 2006 Jan;16(1):87-8, 93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A 21-year-old female with a third ventricular tumor.
  • Intraoperatively, the tumor showed a close relationship to the choroid plexus of the third ventricle.
  • The tumor of our patient is the first reported schwannoma of the third ventricle.
  • They may arise from autonomic perivascular nerves in the choroid plexus or from ectopic neural crest-derived cells.
  • [MeSH-minor] Adult. Brain / pathology. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures

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  • (PMID = 16612987.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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32. Mobley B, Kalani MY, Harsh GR 4th, Edwards MS, Vogel H: Papillary tumor of the spinal cord: report of 2 cases. Am J Surg Pathol; 2009 Aug;33(8):1191-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary tumor of the spinal cord: report of 2 cases.
  • We report 2 pediatric spinal cord tumor cases with unique morphologic and immunohistochemical features.
  • The first patient presented at age 7 with an intramedullary tumor of the thoracic spine.
  • The second patient presented at age 17 with an intramedullary tumor of the cervical spine.
  • The tumor recurred locally and in the cerebellum.
  • The clinical features, including propensity for recurrence and remote subarachnoid spread, and the pathologic features of these tumors are reminiscent of papillary tumor of the pineal region, ependymoma, and choroid plexus papilloma.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Male. Neurosurgical Procedures. Radiotherapy

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  • (PMID = 19417584.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Hasselblatt M, Blümcke I, Jeibmann A, Rickert CH, Jouvet A, van de Nes JA, Kuchelmeister K, Brunn A, Fevre-Montange M, Paulus W: Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Neuropathol Appl Neurobiol; 2006 Jun;32(3):278-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The histopathology of papillary tumours of the pineal region (PTPR) closely resembles that of ependymomas and choroid plexus tumours.
  • In addition to cytokeratin, synaptophysin and glial fibrillary acidic protein expression, PTPR were examined for the presence of dot- or ring-like epithelial membrane antigen (EMA) immunoreactivity typically encountered in ependymoma, staining for inwardly rectifying potassium channel Kir7.1 and stanniocalcin-1 (specifically expressed in choroid plexus tumours) as well as microtubule-associated protein-2 (MAP-2).
  • In contrast, MAP-2 immunoreactivity was encountered in 13 out of 15 PTPR, but was significantly less frequently observed in a series of choroid plexus tumours (7/37).
  • To conclude, the majority of PTPR can be distinguished from ependymomas and choroid plexus tumours by absent staining for epithelial membrane antigen, Kir7.1 and staniocalcin-1 as well as the presence of distinct MAP-2 immunoreactivity.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenocarcinoma, Papillary / metabolism. Biomarkers, Tumor / analysis. Pinealoma / genetics. Pinealoma / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Choroid Plexus Neoplasms / pathology. Chromosome Aberrations. Diagnosis, Differential. Ependymoma / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Nucleic Acid Hybridization

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  • (PMID = 16640646.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Chen J, Balmaceda C, Bruce JN, Sisti MB, Huang M, Cheung YK, McKhann GM, Goodman RR, Fine RL: Tamoxifen paradoxically decreases paclitaxel deposition into cerebrospinal fluid of brain tumor patients. J Neurooncol; 2006 Jan;76(1):85-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tamoxifen paradoxically decreases paclitaxel deposition into cerebrospinal fluid of brain tumor patients.
  • Pgp is highly expressed in the choroid plexus and is thought to be a key component of the blood-cerebrospinal fluid barrier (BCSFB).
  • CONCLUSIONS: The trend towards lower paclitaxel CSF concentrations when given with TAM is consistent with the published finding that Pgp's localization in the endothelial cells of the choroid plexus works in an opposite direction and keeps drugs in the CSF.
  • [MeSH-minor] Administration, Oral. Adult. Aged. Chromatography, High Pressure Liquid. Female. Humans. Infusions, Intravenous. Male. Middle Aged. P-Glycoprotein / antagonists & inhibitors. Prospective Studies

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  • (PMID = 16402278.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA089395
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Antineoplastic Agents, Phytogenic; 0 / P-Glycoprotein; 094ZI81Y45 / Tamoxifen; P88XT4IS4D / Paclitaxel
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35. Gore PA, Nakaji P, Deshmukh V, Rekate HL: Synchronous endoscopy and microsurgery: a novel strategy to approach complex ventricular lesions. Report of three cases. J Neurosurg; 2006 Dec;105(6 Suppl):485-9
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  • The authors present the cases of two children and an adult treated via synchronous approaches.
  • One patient presented with a suprasellar Rathke cyst with a significant third ventricular component, one with a hypothalamic hamartoma having a substantial cisternal component, and the remaining patient with a choroid plexus papilloma in the left lateral ventricle that extended from midbody to the temporal horn.
  • In the case of the choroid plexus papilloma, selective cautery of the choroidal feeding vessels and detachment from the temporal tela choroidea were performed using endoscopy, and the tumor from the ventricular body to the atrium was resected via a craniotomy.
  • [MeSH-minor] Adolescent. Adult. Brain Diseases / pathology. Brain Diseases / surgery. Child. Female. Hamartoma / pathology. Hamartoma / surgery. Humans. Magnetic Resonance Imaging. Male. Papilloma, Choroid Plexus / pathology. Papilloma, Choroid Plexus / surgery

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  • (PMID = 17184083.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Kamnasaran D, Guha A: Expression of GATA6 in the human and mouse central nervous system. Brain Res Dev Brain Res; 2005 Nov 7;160(1):90-5
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  • GATA6 is expressed as a 2.2 kb transcript in the adult mouse brain and several regions of the adult human brain.
  • Furthermore, cellular characterization demonstrates GATA6 nuclear expression in neurons, astrocytes, choroids plexus epithelium, and endothelial cells.
  • [MeSH-minor] Aging / genetics. Aging / metabolism. Animals. Animals, Newborn. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Cell Differentiation / genetics. Cell Line. Choroid Plexus / metabolism. Genes, Tumor Suppressor / physiology. Glioma / genetics. Glioma / metabolism. Humans. Immunohistochemistry. Mice. Protein Isoforms / genetics. Protein Isoforms / metabolism. RNA, Messenger / metabolism

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  • (PMID = 16150495.001).
  • [ISSN] 0165-3806
  • [Journal-full-title] Brain research. Developmental brain research
  • [ISO-abbreviation] Brain Res. Dev. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / GATA6 Transcription Factor; 0 / GATA6 protein, human; 0 / Protein Isoforms; 0 / RNA, Messenger
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37. Harter PN, Bunz B, Dietz K, Hoffmann K, Meyermann R, Mittelbronn M: Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development. Neuropathol Appl Neurobiol; 2010 Dec;36(7):623-35
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  • Distinct co-expression was seen in maturing foetal brainstem nuclei, cerebellar external granular layer and the choroid plexus.
  • [MeSH-major] Brain / embryology. Brain Chemistry / physiology. Nerve Growth Factors / biosynthesis. Receptors, Cell Surface / biosynthesis. Tumor Suppressor Proteins / biosynthesis
  • [MeSH-minor] Adult. Brain Stem / metabolism. Cerebellum / metabolism. Cerebral Cortex / metabolism. Choroid Plexus / metabolism. Ependyma / cytology. Ependyma / metabolism. Female. Fetal Development. Fetus / metabolism. Fluorescent Antibody Technique. Humans. Immunohistochemistry. Pregnancy

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  • [Copyright] © 2010 The Authors. Neuropathology and Applied Neurobiology © 2010 British Neuropathological Society.
  • (PMID = 20609112.001).
  • [ISSN] 1365-2990
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DCC protein, human; 0 / Nerve Growth Factors; 0 / Receptors, Cell Surface; 0 / Tumor Suppressor Proteins; 158651-98-0 / netrin-1
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38. McIver JI, Scheithauer BW, Atkinson JL: Deep Sylvian fissure chordoid meningioma: case report. Neurosurgery; 2005 Nov;57(5):E1064; discussion E1064
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  • The tumor was ultimately resected using standard microsurgical techniques.
  • [MeSH-major] Choroid Plexus Neoplasms / surgery. Meningeal Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Meningioma. Neurosurgery / methods

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  • (PMID = 16284544.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Bollag RJ, Vender JR, Sharma S: Anaplastic meningioma: progression from atypical and chordoid morphotype with morphologic spectral variation at recurrence. Neuropathology; 2010 Jun;30(3):279-87
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  • We present two adult cases of transformed meningiomas that display a spectrum of morphologic progression.
  • The tumor recurred as anaplastic meningioma.
  • Of interest, portions of tumor also showed papillary configuration.
  • We propose that grading of meningiomas as outlined by WHO is of more critical prognostic import than histologic sub-typing, and must include a thorough survey of the tumor-brain interface.
  • [MeSH-major] Choroid Plexus Neoplasms / diagnosis. Choroid Plexus Neoplasms / pathology. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Meningioma / diagnosis. Meningioma / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology

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  • (PMID = 19780983.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
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40. Delmaire C, Gauvrit JY, Hajj E, Ares GS, Ayachi M, Reyns N, Dubois F, Pruvo JP: [Midline tumors of the central nervous system]. J Radiol; 2006 Jun;87(6 Pt 2):764-78
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  • The anatomy of the supratentoriel midline structures of the brain is complex: corpus callosum, third ventricle, trigone, choroid plexus, pineal gland, falx cerebri.
  • These tumors share similar features: minimal clinical symptoms despite their occasional large size, mild non-specific intracranial hypertension syndrome, value of MRI for depiction of tumor location, stereotactic biopsy, relative difficulty of surgical management.
  • [MeSH-minor] Adult. Cerebral Ventricle Neoplasms / diagnosis. Female. Humans. Pineal Gland

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  • (PMID = 16778746.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 30
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41. Bourdeaut F, Fréneaux P, Thuille B, Lellouch-Tubiana A, Nicolas A, Couturier J, Pierron G, Sainte-Rose C, Bergeron C, Bouvier R, Rialland X, Laurence V, Michon J, Sastre-Garau X, Delattre O: hSNF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities. J Pathol; 2007 Feb;211(3):323-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / analysis. Chromosomal Proteins, Non-Histone / analysis. DNA-Binding Proteins / analysis. Kidney Neoplasms / diagnosis. Rhabdoid Tumor / diagnosis. Transcription Factors / analysis
  • [MeSH-minor] Adult. Carcinoma / diagnosis. Carcinoma / genetics. Child, Preschool. Choroid Plexus Neoplasms / diagnosis. Choroid Plexus Neoplasms / genetics. DNA Mutational Analysis. Female. Gene Deletion. Genetic Markers. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence. Infant. Keratins / analysis. Male. Point Mutation. Retrospective Studies. Vimentin / analysis

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  • [Copyright] Copyright 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 17152049.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / SMARCB1 protein, human; 0 / Transcription Factors; 0 / Vimentin; 68238-35-7 / Keratins
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42. Brandenburg LO, Varoga D, Nicolaeva N, Leib SL, Wilms H, Podschun R, Wruck CJ, Schröder JM, Pufe T, Lucius R: Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis. J Neuropathol Exp Neurol; 2008 Nov;67(11):1041-54
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  • The expression of rat cathelin-related antimicrobial peptide in rat glial cells involved different signal transduction pathways and was induced by the inflammatory cytokines interleukin 1beta and tumor necrosis factor.
  • In an experimental model of meningitis, infant rats were intracisternally infected with Streptococcus pneumoniae, and rat cathelin-related antimicrobial peptide was localized in glia, choroid plexus, and ependymal cells by immunohistochemistry.
  • [MeSH-minor] Adolescent. Adult. Aged. Animals. Animals, Newborn. Brain / cytology. Cells, Cultured. Disease Models, Animal. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Muramidase / metabolism. Nitrites / metabolism. RNA, Messenger / metabolism. Rats. Rats, Wistar. Time Factors. Young Adult

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  • (PMID = 18957897.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antimicrobial Cationic Peptides; 0 / Nitrites; 0 / RNA, Messenger; 143108-26-3 / CAP18 lipopolysaccharide-binding protein; EC 3.2.1.17 / Muramidase
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43. Kumar P, Tatke M, Sharma A, Singh D: Histological analysis of lesions of the pineal region: a retrospective study of 12 years. Pathol Res Pract; 2006;202(2):85-92
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  • Various types of tumors and non-tumor lesions arise in the pineal region.
  • Out of these 54 cases, four were non-tumor lesions.
  • The other tumors included germ cell tumors (4/54), meningiomas (2/54), craniopharyngiomas (2/54), and choroid plexus papilloma (1/54).
  • The non-tumor lesions were epidermoid cysts (2/54), tuberculous abscess (1/54), and cysticercosis (1/54).
  • Glial fibrillary acidic protein (GFAP) stained only the reactive astrocytes in these tumors except two cases of pineoblastoma, which showed GFAP positivity in some tumor cells, indicating glial differentiation.
  • [MeSH-minor] Adolescent. Adult. Cell Differentiation. Child. Child, Preschool. Epidermal Cyst / pathology. Glioma / pathology. Humans. Infant. Male. Middle Aged. Neoplasms, Germ Cell and Embryonal / pathology. Pineal Gland. Retrospective Studies

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  • (PMID = 16413691.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Hu WW, Zheng XJ, Shen G, Liu WG, Shen H, Fu WM, Zhou JY: [Diagnosis and micro-neurosurgery for the fourth cerebral ventricle tumors]. Zhonghua Zhong Liu Za Zhi; 2007 Feb;29(2):144-6

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  • METHODS: Tumor of the fourth ventricle was clinically diagnosed in 86 patients basing on the preliminary assessment of symptom and CT or MRI findings.
  • The pathology included 32 medulloblastomas, 23 ependymoma, 15 astrocytoma, 10 hemangiblastomas, 2 choroid plexus papillomas, and 4 epidermoid cysts.
  • CONCLUSION: Medulloblastoma, astrocytoma and hemangiblastoma are suggested to be removed totally whenever technically possible according to the site, character and volume of the tumor.
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / diagnosis. Astrocytoma / radiography. Astrocytoma / surgery. Child. Child, Preschool. Combined Modality Therapy. Ependymoma / diagnosis. Ependymoma / radiography. Ependymoma / surgery. Female. Follow-Up Studies. Hemangioblastoma / diagnosis. Hemangioblastoma / radiography. Hemangioblastoma / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Survival Analysis. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 17645855.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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45. Güneş M, Günaldi O, Tuğcu B, Tanriverdi O, Güler AK, Cöllüoğlu B: Intracranial chondrosarcoma: a case report and review of the literature. Minim Invasive Neurosurg; 2009 Oct;52(5-6):238-41
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  • INTRODUCTION: Chondrosarcoma is a rare malignant tumor originating from cartilagenous tissue.
  • The tumor was removed totally by a microsurgical technique.
  • The choroid plexus, dura mater and brain parenchyma are extremely rarely invaded.
  • Meningiomas, solitary fibrous tumor, chordoma, hemangiopericytoma, metastasis and vascular malformations should be considered as differential diagnoses.
  • Radical surgical removal of the tumor is the preferred management procedure.
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Neurosurgical Procedures. Prognosis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20077365.001).
  • [ISSN] 1439-2291
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 26
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46. Kasliwal MK, Suri A, Rishi A, Suri V, Sharma BS, Sarkar C: Symptomatic bilateral cerebellar mass lesions: an unusual presentation of intracranial xanthogranuloma. J Clin Neurosci; 2008 Dec;15(12):1401-4
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  • Although the lateral ventricle is the most frequent intracranial site involved, most symptomatic cases occur in the choroid plexus, involving the third ventricle.
  • The role of histopathology cannot be overemphasized in the diagnosis of this rare lesion and long-term follow-up is advised in cases managed conservatively owing to the propensity of this tumor to grow over time.
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 18952438.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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47. Oshio K, Binder DK, Liang Y, Bollen A, Feuerstein B, Berger MS, Manley GT: Expression of the aquaporin-1 water channel in human glial tumors. Neurosurgery; 2005 Feb;56(2):375-81; discussion 375-81
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  • In the central nervous system, AQP1 is selectively expressed in the choroid plexus and thought to participate in cerebrospinal fluid production.
  • Prior studies have suggested that AQP1 may be up-regulated in glial tumors, potentially contributing to tumor-associated edema.
  • RESULTS: AQP1, normally restricted to choroid epithelia, was highly expressed in glioblastomas.
  • CONCLUSION: The abnormal up-regulation of AQP1 in glial tumors suggests a potential pathological role for this membrane water channel and raises the possibility that selective AQP1 inhibition might offer a new therapeutic target for treatment of tumor-associated edema.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15670385.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AQP1 protein, human; 146410-94-8 / Aquaporin 1
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48. Simin K, Hill R, Song Y, Zhang Q, Bash R, Cardiff RD, Yin C, Xiao A, McCarthy K, van Dyke T: Deciphering cancer complexities in genetically engineered mice. Cold Spring Harb Symp Quant Biol; 2005;70:283-90
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  • Because the pRb pathway is disrupted in most solid human cancers, we have generated genetically engineered mouse cancer models by inactivating pRb function in several cell types, including astrocytes and mammary, prostate, ovarian, and brain choroid plexus epithelia.
  • Cell type dictates the pathways involved in tumor progression.
  • In the astrocytoma model, we developed strategies to induce events in the adult brain, either throughout the tissue or focally.

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  • (PMID = 16869764.001).
  • [ISSN] 0091-7451
  • [Journal-full-title] Cold Spring Harbor symposia on quantitative biology
  • [ISO-abbreviation] Cold Spring Harb. Symp. Quant. Biol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA46283; United States / NCI NIH HHS / CA / U01-CA84294; United States / NCI NIH HHS / CA / U01-CA84314
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein; EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
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49. Zenzmaier C, Marksteiner J, Kiefer A, Berger P, Humpel C: Dkk-3 is elevated in CSF and plasma of Alzheimer's disease patients. J Neurochem; 2009 Jul;110(2):653-61
The Lens. Cited by Patents in .

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  • The present study investigated whether the glycoprotein and putative tumor suppressor Dickkopf homolog 3 (Dkk-3) is secreted into CSF and evaluated its applicability as a diagnostic marker for AD.
  • Consistently Dkk-3 expression was demonstrated in neurons of the cortex and epithelial cells of the choroid plexus, the major source of CSF.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amino Acid Sequence. Biomarkers / blood. Biomarkers / cerebrospinal fluid. Brain / metabolism. Brain / pathology. Cognition Disorders / blood. Cognition Disorders / cerebrospinal fluid. Cognition Disorders / diagnosis. Depression / blood. Depression / cerebrospinal fluid. Depression / diagnosis. Humans. Male. Middle Aged. Molecular Sequence Data

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  • (PMID = 19457090.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / L 429
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / DKK3 protein, human; 0 / Intercellular Signaling Peptides and Proteins
  • [Other-IDs] NLM/ EMS32768; NLM/ PMC4311140
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50. Olson MV, Johnson DG, Jiang H, Xu J, Alonso MM, Aldape KD, Fuller GN, Bekele BN, Yung WK, Gomez-Manzano C, Fueyo J: Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res; 2007 May 1;67(9):4005-9
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  • Importantly, the distribution of tumors according to mouse age suggests the existence of a bimodal pattern of tumor development, forcing a comparison with the human disease.
  • Mice, at an early age, with deregulated E2F1 show the formation of embryonal brain tumors such as medulloblastoma, choroid plexus carcinoma, and primary neuroectodermal tumor.
  • Conversely, at an older age, mice escaping embryonal tumor formation present with malignant gliomas, which are typically identified in the human adult population.

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  • (PMID = 17483310.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16672; United States / NIEHS NIH HHS / ES / ES007784; United States / NCI NIH HHS / CA / R01CA79648
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / E2F1 Transcription Factor; 0 / E2F1 protein, human
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51. Jacobs JF, Grauer OM, Brasseur F, Hoogerbrugge PM, Wesseling P, Gidding CE, van de Rakt MW, Figdor CG, Coulie PG, de Vries IJ, Adema GJ: Selective cancer-germline gene expression in pediatric brain tumors. J Neurooncol; 2008 Jul;88(3):273-80
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  • Fifty-five percent of the medulloblastomas (n = 11), 86% of the ependymomas (n = 7), 40% of the choroid plexus tumors (n = 5) and 67% of astrocytic tumors (n = 27) expressed one or more CGGs.
  • CGG-encoded antigens are therefore suitable targets in a very selected group of pediatric patients with a brain tumor.
  • Interestingly, glioblastomas from adult patients expressed CGGs more often and at significantly higher levels compared to pediatric glioblastomas.
  • This observation is in line with the notion that pediatric and adult glioblastomas develop along different genetic pathways.
  • [MeSH-major] Brain Neoplasms / genetics. Gene Expression. Genes, Neoplasm
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Humans. Immunohistochemistry. Infant. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18398575.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2440921
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52. Kieran MW, Supko JG, Wallace D, Fruscio R, Poussaint TY, Phillips P, Pollack I, Packer R, Boyett JM, Blaney S, Banerjee A, Geyer R, Friedman H, Goldman S, Kun LE, Macdonald T, Pediatric Brain Tumor Consortium: Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. Pediatr Blood Cancer; 2009 Feb;52(2):169-76
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  • Tumor types included 23 glial tumors, 4 neural tumors, 4 ependymomas, and 2 choroid plexus carcinomas.
  • The plasma pharmacokinetics of SU5416 in children was similar to previously reported findings in adult cancer patients.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 19065567.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA081457-07; United States / NCI NIH HHS / CA / U01 CA081457; United States / NCI NIH HHS / CA / U01 CA081457-07; United States / NCI NIH HHS / CA / U01 CA81457
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Anticonvulsants; 0 / Indoles; 0 / Protein Kinase Inhibitors; 0 / Pyrroles; 71IA9S35AJ / Semaxinib; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor
  • [Other-IDs] NLM/ NIHMS124020; NLM/ PMC2775441
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53. Galt JR, Halkar RK, Evans CO, Osman NA, LaBorde D, Fox TH, Faraj BA, Kumar K, Wang H, Oyesiku NM: In vivo assay of folate receptors in nonfunctional pituitary adenomas with 99mTc-folate SPECT/CT. J Nucl Med; 2010 Nov;51(11):1716-23
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  • Receiver-operating-characteristic curve analysis of quantitative uptake yielded a tumor-to-background cutoff ratio of 3.5, with a sensitivity of 81% and specificity of 83%.
  • Scalp uptake yielded consistent results (over the brain, neck, and choroid plexus) for background when SPECT/CT misalignment artifacts were avoided.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. ROC Curve. Sensitivity and Specificity

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  • (PMID = 20956474.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS051439-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Folate Receptors, GPI-Anchored; 0 / Organotechnetium Compounds; 935E97BOY8 / Folic Acid
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54. Torii K, Tsuyuguchi N, Kawabe J, Sunada I, Hara M, Shiomi S: Correlation of amino-acid uptake using methionine PET and histological classifications in various gliomas. Ann Nucl Med; 2005 Dec;19(8):677-83
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  • OBJECTIVE: The uptake of L-methyl-11C-methionine (MET) by gliomas is greater than that by intact tissue, making methionine very useful for evaluation of tumor extent.
  • Tumors included diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, ependymoma, oligodendroglioma, medulloblastoma, dysembryoplastic neuroepithelial tumor, choroid plexus papilloma, central neurocytoma, optic glioma, gliomatosis cerebri, pleomorphic xanthoastrocytoma, and ganglioglioma.
  • Tumor activity and degree of malignancy were evaluated using Ki-67LI (LI: labeling index) and Kaplan-Meier survival curves.
  • The correlations between methionine uptake and tumor proliferation (tumor versus contralateral gray matter ratio (T/N) and Ki-67LI) were determined for the group of all subjects.
  • Ki-67LI differed significantly between the high-grade group and low-grade group at T/N levels between 1.5 and 1.8 on analysis using tumor proliferative potential (p = 0.019-0.031).
  • CONCLUSIONS: When analysis was confined to cases of astrocytic tumor, a correlation was noted between methionine accumulation and Ki-67LI.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Image Interpretation, Computer-Assisted / methods. Male. Middle Aged. ROC Curve. Radiopharmaceuticals / pharmacokinetics. Reproducibility of Results. Sensitivity and Specificity. Statistics as Topic. Tissue Distribution

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  • (PMID = 16444993.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 58576-49-1 / carbon-11 methionine; AE28F7PNPL / Methionine
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55. Gonzalez KD, Noltner KA, Buzin CH, Gu D, Wen-Fong CY, Nguyen VQ, Han JH, Lowstuter K, Longmate J, Sommer SS, Weitzel JN: Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol; 2009 Mar 10;27(8):1250-6
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  • Every individual with a choroid plexus tumor (eight of eight) and 14 of 21 individuals with a childhood ACC had a mutation regardless of family history.
  • [MeSH-minor] Adolescent. Adrenal Cortex Neoplasms / genetics. Adult. Age of Onset. Breast Neoplasms / genetics. Child. Child, Preschool. Female. Genotype. Humans. Infant. Male. Middle Aged

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  • [CommentIn] J Clin Oncol. 2009 Sep 10;27(26):e108-9; author reply e110 [19652052.001]
  • (PMID = 19204208.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Gazzola S, Aviv RI, Gladstone DJ, Mallia G, Li V, Fox AJ, Symons SP: Vascular and nonvascular mimics of the CT angiography "spot sign" in patients with secondary intracerebral hemorrhage. Stroke; 2008 Apr;39(4):1177-83
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  • RESULTS: No patients with secondary ICH had a true CTA Spot Sign, but several Spot Sign mimics were identified including: micro AVM, posterior communicating artery aneurysm, Moya Moya, and neoplasm-associated calcification.
  • CONCLUSIONS: This study describes mimics of the CTA Spot Sign and classifies them as vascular (microAVM, aneurysm, Moya Moya) or nonvascular (tumor and choroid plexus calcification).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Arteriovenous Fistula / complications. Arteriovenous Fistula / radiography. Brain Neoplasms / complications. Brain Neoplasms / radiography. Diagnosis, Differential. Female. Hematoma / etiology. Hematoma / radiography. Humans. Intracranial Arteriovenous Malformations / complications. Intracranial Arteriovenous Malformations / radiography. Male. Middle Aged. Moyamoya Disease / complications. Moyamoya Disease / radiography. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 18292380.001).
  • [ISSN] 1524-4628
  • [Journal-full-title] Stroke; a journal of cerebral circulation
  • [ISO-abbreviation] Stroke
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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57. Sigauke E, Rakheja D, Maddox DL, Hladik CL, White CL, Timmons CF, Raisanen J: Absence of expression of SMARCB1/INI1 in malignant rhabdoid tumors of the central nervous system, kidneys and soft tissue: an immunohistochemical study with implications for diagnosis. Mod Pathol; 2006 May;19(5):717-25
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  • The histologic diagnosis of malignant rhabdoid tumor depends on identification of characteristic rhabdoid cells-large cells with eccentrically located nuclei and abundant, eosinophilic cytoplasm-and immunohistochemistry with antibodies to vimentin, keratin and epithelial membrane antigen.
  • In total, 12 brain, three renal and two soft tissue rhabdoid tumors were examined along with four glioblastomas, four pilocytic astrocytomas, four oligodendrogliomas, two ependymomas, two choroid plexus papillomas, five pituitary adenomas, four germinomas, four renal carcinomas with Xp11.2 translocations, two clear cell sarcomas, two Wilms' tumors, one renal medullary carcinoma, two desmoplastic small round cell tumors, two alveolar rhabdomyosarcomas, two embryonal rhabdomyosarcomas, one low-grade chondrosarcoma, two extraskeletal myxoid chondrosarcomas, one mesenchymal chondrosarcoma, four malignant peripheral nerve sheath tumors, five metastatic carcinomas and four epithelioid sarcomas, two primary and two metastatic.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. DNA-Binding Proteins / biosynthesis. Kidney Neoplasms / pathology. Rhabdoid Tumor / pathology. Soft Tissue Neoplasms / pathology. Transcription Factors / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Child. Child, Preschool. Chromosomal Proteins, Non-Histone. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Middle Aged

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  • (PMID = 16528370.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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58. Das P, Kumar N, Ahuja A, Jain A, Ray R, Sarkar C, Gupta SD: Primary malignant melanoma at unusual sites: an institutional experience with review of literature. Melanoma Res; 2010 Jun;20(3):233-9
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  • Apart from the skin and choroid plexus, primary malignant melanoma is rare at the other sites and lacks organized documentation.
  • Gross tumor appearance and the unavailability of an immunohistochemical panel, may result in their misdiagnosis as primary epithelial malignancies.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Genital Neoplasms, Female / diagnosis. Genital Neoplasms, Female / pathology. Humans. Immunohistochemistry / methods. Male. Medical Oncology / methods. Middle Aged. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 20386135.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 44
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59. Larysz D, Blamek S, Larysz P, Pietras K, Mandera M: Posterior fossa brain tissue injury: developmental, neuropsychological, and neurological consequences of brain tumors in children. Acta Neurochir Suppl; 2010;106:271-4
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  • The aim of the study was the functional neurodevelopmental assessment of children with posterior fossa tumors, specifically examining whether tumor location in particular cerebellar structures determines particular neuropsychological deficits.
  • There were 21 total and 8 subtotal resections of tumor, and marsupialization was performed in cases of arachnoid cysts.
  • Histopathological diagnoses of tumors were as follows: 4 medulloblastomas, 8 pilocytic astrocytomas, 6 fibrillary astrocytomas, 1 anaplastic astrocytoma, 2 oligodendrogliomas, 4 anaplastic ependymomas, 1 choroid plexus papilloma, and 5 arachnoid cysts.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Functional Laterality / physiology. Humans. Male. Neuropsychological Tests. Retrospective Studies. Young Adult

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  • (PMID = 19812963.001).
  • [ISSN] 0065-1419
  • [Journal-full-title] Acta neurochirurgica. Supplement
  • [ISO-abbreviation] Acta Neurochir. Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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60. Xiong J, Wang Y: [Cystic mass in left temporal bone]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):198-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Choroid Plexus Neoplasms / pathology. Diagnosis, Differential. Glomus Jugulare Tumor / pathology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Meningioma / pathology. Tomography, X-Ray Computed

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  • (PMID = 19575859.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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61. Gulwani H, Roy S: 44-year-old man with abnormal gait. Brain Pathol; 2008 Oct;18(4):605-6
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  • [MeSH-major] Cerebral Ventricle Neoplasms / complications. Cerebral Ventricle Neoplasms / pathology. Gait Disorders, Neurologic / etiology. Gait Disorders, Neurologic / pathology. Papilloma, Choroid Plexus / complications. Papilloma, Choroid Plexus / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy. Brain Stem / pathology. Brain Stem / physiopathology. Calcinosis / pathology. Calcinosis / physiopathology. Diagnosis, Differential. Fourth Ventricle / pathology. Fourth Ventricle / physiopathology. Humans. Male. Neurosurgical Procedures. Tomography, X-Ray Computed. Treatment Outcome. Ventriculostomy

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  • (PMID = 18782175.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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