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1. Kamphues C, Seehofer D, Eisele RM, Denecke T, Pratschke J, Neumann UP, Neuhaus P: Recurrent intrahepatic cholangiocarcinoma: single-center experience using repeated hepatectomy and radiofrequency ablation. J Hepatobiliary Pancreat Sci; 2010 Jul;17(4):509-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent intrahepatic cholangiocarcinoma: single-center experience using repeated hepatectomy and radiofrequency ablation.
  • BACKGROUND: Intrahepatic cholangiocarcinoma (IHC) is a rare liver malignancy with a rising incidence worldwide.
  • RESULTS: After a median follow-up period of 28 months after primary liver resection (12-69 months), seven patients (54%) are still alive and three of these patients (23% of the entire cohort) are regarded as disease-free.
  • One- and three-year survival after primary surgery was 92 and 52%, respectively, with an overall complication rate of 7.6%.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Catheter Ablation / methods. Cholangiocarcinoma / surgery. Hepatectomy / methods. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Adult. Aged. Biopsy. Female. Follow-Up Studies. Germany / epidemiology. Humans. Incidence. Male. Middle Aged. Reoperation. Retrospective Studies. Survival Rate / trends. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20714840.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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2. Chang YH, Chuang CK, Ng KF, Liao SK: Klatskin tumor with spermatic cord metastasis: a case report. Chang Gung Med J; 2009 Jan-Feb;32(1):104-7
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  • He had a Klatskin tumor (cholangiocarcinoma) stage IIIa, and underwent an extended right hepatectomy with resection of the extrahepatic bile duct, and portal vein and reconstruction by Roux-en-y hepatico-jejunostomy one year before this presentation.
  • The primary cholangiocarcinoma tumor and the spermatic cord tumor showed identical histologic patterns.
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 19292946.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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3. Amarapurkar AD, Rege JD, Joshi AS, Vaiphei K, Amarapurkar DN: Utilization of antihepatocyte clone OCH1E5 (Hep Par 1) in histological evaluation of liver tumors. Indian J Pathol Microbiol; 2006 Jul;49(3):341-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diagnosis of hepatocellular carcinoma (HCC) is not always easy on simple hematoxylin and eosin (H&E) stain.
  • The aim of the present study was to determine utility of Hep Par 1 (OCH1E5) in differentiating HCC from metastatic tumors and cholangiocarcinoma.
  • Slides having representative sections were subjected to immunohistochemistry with monoclonal antibody Hep Par 1 (Dako Corp) using avidin biotin technique with primary antibody dilution of 1:40.
  • None of the cases of cholangiocarcinoma showed positivity for Hep Par 1.
  • Hep Par 1 is a useful marker in differentiating HCC from metastaic tumors and cholangiocarcinoma with sensitivity and specificity of 89 % and 97 % respectively and positive predictive value of 96 %.
  • [MeSH-major] Antibodies, Monoclonal. Antibodies, Neoplasm / immunology. Biomarkers, Tumor. Carcinoma, Hepatocellular / pathology. Hepatocytes / immunology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, Neoplasm / immunology. Antigens, Surface / immunology. Biopsy. Cell Differentiation / immunology. Diagnosis, Differential. Humans. Immunohistochemistry. Liver / metabolism. Liver / pathology. Neoplasm Metastasis. Sensitivity and Specificity

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  • (PMID = 17001880.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Antigens, Surface; 0 / Biomarkers, Tumor
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4. Milias K, Madhavan KK, Bellamy C, Garden OJ, Parks RW: Inflammatory pseudotumors of the liver: experience of a specialist surgical unit. J Gastroenterol Hepatol; 2009 Sep;24(9):1562-6
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  • Two patients presented with liver abscesses, one with liver cystadenoma, and one with hilar cholangiocarcinoma.
  • [MeSH-minor] Adult. Aged. Diagnostic Errors / prevention & control. Female. Humans. Liver Abscess / diagnosis. Liver Neoplasms / diagnosis. Male. Middle Aged. Surgery Department, Hospital. Treatment Outcome

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  • (PMID = 19744000.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 28
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5. Hong SM, Pawlik TM, Cho H, Aggarwal B, Goggins M, Hruban RH, Anders RA: Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma. Surgery; 2009 Aug;146(2):250-7
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  • [Title] Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma.
  • BACKGROUND: The American Joint Committee on Cancer (AJCC) T classification system for cholangiocarcinoma does not take into account the unique pathologic features of the bile duct.
  • As such, the current AJCC T classification for distal cholangiocarcinoma may be inaccurate.
  • METHODS: A total of 147 patients with distal cholangiocarcinoma were identified from a single institution database.
  • CONCLUSION: The AJCC T classification for distal cholangiocarcinoma does not accurately predict prognosis.
  • Depth of the bile duct carcinoma invasion is a better alternative method to determine prognosis and should be incorporated into the pathologic assessment of resected distal cholangiocarcinoma.

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  • (PMID = 19628081.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK067187; United States / NIDDK NIH HHS / DK / DK076291-01; United States / NIDDK NIH HHS / DK / K08-DK67187; United States / NIDDK NIH HHS / DK / L30 DK076291-01; United States / NCRR NIH HHS / RR / 1KL2RR025006-01; United States / NCRR NIH HHS / RR / KL2 RR025006; United States / NIDDK NIH HHS / DK / R01-DK081417; United States / NIDDK NIH HHS / DK / R01 DK081417
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS388286; NLM/ PMC3402913
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6. Lim MK, Ju YH, Franceschi S, Oh JK, Kong HJ, Hwang SS, Park SK, Cho SI, Sohn WM, Kim DI, Yoo KY, Hong ST, Shin HR: Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea. Am J Trop Med Hyg; 2006 Jul;75(1):93-6
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  • [Title] Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea.
  • To evaluate the prevalence and risk factors of Clonorchis sinensis infection, an epidemiologic survey was performed (3,169 residents; age range: 30-87 years; mean age = 59; 1,973 women) in three areas with different mortality rates of cholangiocarcinoma. C. sinensis prevalence was 2.1% in Chuncheon, 7.8% in Chungju, and 31.3% in Haman, where cholangiocarcinoma incidence rate was 0.3, 1.8, and 5.5 per 100,000 persons, respectively.
  • [MeSH-major] Bile Duct Neoplasms / epidemiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / epidemiology. Clonorchiasis / epidemiology. Clonorchis sinensis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Alcohol Drinking. Animals. Feces / parasitology. Female. Fishes. Geography. Humans. Korea / epidemiology. Male. Middle Aged. Risk Factors. Sex Factors

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  • (PMID = 16837714.001).
  • [ISSN] 0002-9637
  • [Journal-full-title] The American journal of tropical medicine and hygiene
  • [ISO-abbreviation] Am. J. Trop. Med. Hyg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Ali S, Shah V: Small-duct primary sclerosing cholangitis with hepatocellular carcinoma requiring liver transplantation. Hepatobiliary Pancreat Dis Int; 2010 Apr;9(2):208-12
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  • [Title] Small-duct primary sclerosing cholangitis with hepatocellular carcinoma requiring liver transplantation.
  • BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease, which usually affects young adults and is diagnosed by cholangiography.
  • RESULTS: The patient's explanted liver showed changes of PSC affecting only the small- and medium-sized bile ducts in addition to three incidental nodules of hepatocellular carcinoma.
  • CONCLUSIONS: Small-duct PSC has a substantially better prognosis than the large-duct type, with less chance of developing cirrhosis and an equal risk for developing hepatocellular carcinoma, but no increased risk for developing cholangiocarcinoma.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Cholangitis, Sclerosing / surgery. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Adult. Humans. Male


8. Yönem O, Ozkayar N, Balkanci F, Harmanci O, Sökmensüer C, Ersoy O, Bayraktar Y: Is congenital hepatic fibrosis a pure liver disease? Am J Gastroenterol; 2006 Jun;101(6):1253-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In two cases, cholangiocarcinoma had developed.
  • [MeSH-minor] Adolescent. Adult. Biopsy. Diagnostic Imaging. Female. Humans. Male. Middle Aged. Prospective Studies. Survival Analysis


9. Campos Franco J, Mallo González N, Vieites Pérez-Quintela B, Gallardo Martín E: [Intrahepatic cholangiocarcinoma]. Med Clin (Barc); 2008 Nov 15;131(17):680
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intrahepatic cholangiocarcinoma].
  • [MeSH-major] Bile Duct Neoplasms. Bile Ducts, Intrahepatic. Cholangiocarcinoma. Radiography, Abdominal. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Immunohistochemistry. Male


10. Millwala F, Segev DL, Thuluvath PJ: Caroli's disease and outcomes after liver transplantation. Liver Transpl; 2008 Jan;14(1):11-7
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  • Caroli's disease is a rare autosomal recessive disorder characterized by intrahepatic cystic dilatation of the bile ducts that, when progressive, leads to intrahepatic stones, recurrent cholangitis, portal hypertension, cholangiocarcinoma, and liver failure.
  • In conclusion, liver transplantation is an excellent treatment option for patients with advanced Caroli's disease and should be considered in a timely fashion to prevent worsening complications including refractory cholangitis and cholangiocarcinoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Graft Survival. Humans. Infant. Infant, Newborn. Kidney Failure, Chronic / complications. Kidney Failure, Chronic / epidemiology. Kidney Failure, Chronic / surgery. Kidney Transplantation / methods. Male. Middle Aged. Morbidity / trends. Retrospective Studies. Survival Rate / trends. Time Factors. Treatment Outcome

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  • [Copyright] (c) 2007 AASLD.
  • [CommentIn] Liver Transpl. 2008 Jan;14(1):2-3 [18161795.001]
  • (PMID = 18161799.001).
  • [ISSN] 1527-6465
  • [Journal-full-title] Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • [ISO-abbreviation] Liver Transpl.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Kim HJ, Lee JM, Kim SH, Han JK, Lee JY, Choi JY, Kim KH, Kim JY, Lee MW, Kim SJ, Choi BI: Evaluation of the longitudinal tumor extent of bile duct cancer: value of adding gadolinium-enhanced dynamic imaging to unenhanced images and magnetic resonance cholangiography. J Comput Assist Tomogr; 2007 May-Jun;31(3):469-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHOD: Thirty-three patients with hilar cholangiocarcinoma or common duct cancer who had undergone MRC, unenhanced, and gadolinium-enhanced dynamic MR images and surgery were included in this study.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Cholangiocarcinoma / pathology. Cholangiopancreatography, Magnetic Resonance
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Female. Humans. Image Processing, Computer-Assisted. Male. Meglumine / analogs & derivatives. Middle Aged. Organometallic Compounds. ROC Curve

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  • (PMID = 17538298.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine
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12. Kim JW, Jo S, Moon HJ, Heo JS, Choi SH, Joh JW, Choi DW, Chung JC, Kim YI: [Prognostic factors after major resection for distal extrahepatic cholangiocarcinoma]. Korean J Gastroenterol; 2006 Feb;47(2):144-52
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  • [Title] [Prognostic factors after major resection for distal extrahepatic cholangiocarcinoma].
  • Thus, we evaluated the outcomes and prognostic factors after major resection for distal extrahepatic cholangiocarcinoma (dCC).
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adult. Aged. Biliary Tract Surgical Procedures. Female. Humans. Male. Middle Aged. Prognosis. Risk Factors. Survival Rate

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  • (PMID = 16498281.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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13. Granov DA, Ten VP, Rasskazov AK, Pozharskiĭ KM: [Angiogenetic features in liver carcinoma and their prognostic value: clinical and immunohistochemical study]. Arkh Patol; 2006 Nov-Dec;68(6):6-10
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  • [Title] [Angiogenetic features in liver carcinoma and their prognostic value: clinical and immunohistochemical study].
  • Survival rates were studied in 57 patients with primary liver carcinoma (including 32 with hepatocellular carcinoma [HCC] and 25 with cholangiocellular carcinoma [CCC] in relation to the histological type of a tumor and its microcirculatory bed.
  • [MeSH-major] Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Liver Neoplasms / mortality. Liver Neoplasms / pathology. Neovascularization, Pathologic / mortality. Neovascularization, Pathologic / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17290884.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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14. Stauffer JA, Steers JL, Bonatti H, Dougherty MK, Aranda-Michel J, Dickson RC, Harnois DM, Nguyen JH: Liver transplantation and pancreatic resection: a single-center experience and a review of the literature. Liver Transpl; 2009 Dec;15(12):1728-37
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  • Indications for pancreatic resection included cholangiocarcinoma (n = 6), neuroendocrine tumor (n = 5), pancreatic cancer (n = 2), gastrointestinal stromal tumor (n = 1), periampullary adenocarcinoma (n = 1), duodenal adenomas (n = 1), and benign pancreatic mass (n = 1).
  • Indications for liver transplantation were metastatic neuroendocrine tumor disease (n = 5), primary sclerosing cholangitis (n = 5), hepatitis C virus (n = 2), metastatic gastrointestinal stromal tumor (n = 1), Klatskin tumor (n = 1), alcohol cirrhosis (n = 1), alpha-1 antitrypsin deficiency (n = 1), and chemotherapy-induced cirrhosis (n = 1).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Patient Selection. Recurrence. Risk Assessment. Time Factors. Treatment Outcome. Young Adult


15. Hughes NR, Pairojkul C, Royce SG, Clouston A, Bhathal PS: Liver fluke-associated and sporadic cholangiocarcinoma: an immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes. J Clin Pathol; 2006 Oct;59(10):1073-8
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  • [Title] Liver fluke-associated and sporadic cholangiocarcinoma: an immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes.
  • AIM: To compare cell phenotypes displayed by cholangiocarcinomas and adjacent bile duct lesions in patients from an area endemic in liver-fluke infestation and those with sporadic cholangiocarcinoma.
  • When present together in a cholangiocarcinoma, cancer cells expressing D10 were distinct from those displaying 17NM or MUC5AC.
  • Pyloric gland metaplasia and peribiliary glands displayed D10 and 1F6, with peribiliary gland hyperplasia more evident in the livers with fluke-associated cholangiocarcinoma; goblet cells in intestinal metaplasia stained for 17NM.
  • CONCLUSIONS: Most cases of dysplastic biliary epithelium and cholangiocarcinoma display a Brunner or pyloric gland cell phenotype and a gastric foveolar cell phenotype.
  • The expression of D10 in hyperplastic and dysplastic epithelium and in cholangiocarcinoma is consistent with a dysplasia-carcinoma sequence.
  • Many more fluke-associated cholangiocarcinomas than sporadic cholangiocarcinoma display an intestinal goblet cell phenotype and overexpress p53, indicating differences in the aetiopathology of the cancers in the two groups of patients.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Bile Duct Neoplasms / parasitology. Bile Ducts, Intrahepatic / metabolism. Cholangiocarcinoma / parasitology. Fascioliasis / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Humans. Hyperplasia / metabolism. Hyperplasia / parasitology. Male. Metaplasia / metabolism. Metaplasia / parasitology. Middle Aged. Phenotype. Precancerous Conditions / metabolism. Precancerous Conditions / parasitology. Precancerous Conditions / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16679351.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC1861757
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16. Shim CS, Cheon YK, Cha SW, Bhandari S, Moon JH, Cho YD, Kim YS, Lee LS, Lee MS, Kim BS: Prospective study of the effectiveness of percutaneous transhepatic photodynamic therapy for advanced bile duct cancer and the role of intraductal ultrasonography in response assessment. Endoscopy; 2005 May;37(5):425-33
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  • CONCLUSIONS: PDT using percutaneous cholangioscopy is safe and effective for advanced hilar cholangiocarcinoma, and seems to prolong survival.
  • [MeSH-major] Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / drug therapy. Photochemotherapy / methods
  • [MeSH-minor] Adult. Aged. Endosonography. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Male. Middle Aged. Prospective Studies. Quality of Life. Survival Rate. Treatment Outcome

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  • (PMID = 15844020.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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17. Korita PV, Wakai T, Ajioka Y, Inoue M, Takamura M, Shirai Y, Hatakeyama K: Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma. Anticancer Res; 2010 Jun;30(6):2279-85
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  • [Title] Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma.
  • BACKGROUND: This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC).
  • [MeSH-major] Bile Duct Neoplasms / mortality. Bile Ducts, Intrahepatic. Cholangiocarcinoma / mortality. Vimentin / physiology
  • [MeSH-minor] Adult. Aged. Cell Differentiation. Epithelial Cells / pathology. Female. Humans. Male. Mesoderm / pathology. Middle Aged. Prognosis


18. Rudolph G, Kloeters-Plachky P, Rost D, Stiehl A: The incidence of cholangiocarcinoma in primary sclerosing cholangitis after long-time treatment with ursodeoxycholic acid. Eur J Gastroenterol Hepatol; 2007 Jun;19(6):487-91
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  • [Title] The incidence of cholangiocarcinoma in primary sclerosing cholangitis after long-time treatment with ursodeoxycholic acid.
  • BACKGROUND/AIMS: Cholangiocarcinoma represents a serious complication of primary sclerosing cholangitis.
  • Ursodeoxycholic acid may possibly influence the incidence of cholangiocarcinoma in man.
  • The aim of this study was to evaluate the incidence rate of cholangiocarcinoma in a large group of primary sclerosing cholangitis patients after long-time treatment with ursodeoxycholic acid.
  • PATIENTS AND METHODS: From May 1987 up to May 2005 a total of 150 patients with primary sclerosing cholangitis but without evidence of cholangiocarcinoma at entry were included in the study.
  • Altogether five patients developed a cholangiocarcinoma during treatment yielding a rate of 3.3%.
  • The patients developed 0.58 cholangiocarcinoma per 100 patient-years in years 0-2.5, 0.59 cholangiocarcinoma in years 2.5-8.5, and no cholangiocarcinoma thereafter up to 18 years after entry into the study.
  • The Kaplan-Meier estimate of cholangiocarcinoma incidence during ursodeoxycholic acid treatment reached a plateau after 8.3 years.
  • SUMMARY AND CONCLUSION: The annual incidence rate of cholangiocarcinoma in primary sclerosing cholangitis treated with ursodeoxycholic acid is lower than expected and decreases with time of treatment.
  • [MeSH-major] Bile Duct Neoplasms / chemically induced. Bile Ducts, Intrahepatic / drug effects. Cholagogues and Choleretics / adverse effects. Cholangiocarcinoma / chemically induced. Cholangitis, Sclerosing / drug therapy. Ursodeoxycholic Acid / adverse effects
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cholestasis, Intrahepatic / etiology. Female. Humans. Long-Term Care / methods. Male. Middle Aged. Patient Dropouts. Prospective Studies

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  • (PMID = 17489059.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cholagogues and Choleretics; 724L30Y2QR / Ursodeoxycholic Acid
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19. Choi SB, Kim KS, Choi JY, Park SW, Choi JS, Lee WJ, Chung JB: The prognosis and survival outcome of intrahepatic cholangiocarcinoma following surgical resection: association of lymph node metastasis and lymph node dissection with survival. Ann Surg Oncol; 2009 Nov;16(11):3048-56
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  • [Title] The prognosis and survival outcome of intrahepatic cholangiocarcinoma following surgical resection: association of lymph node metastasis and lymph node dissection with survival.
  • BACKGROUND: Surgical resection has been shown to improve long-term survival for patients with intrahepatic cholangiocarcinoma (ICC).
  • [MeSH-major] Bile Duct Neoplasms / mortality. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / mortality. Lymph Nodes / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Laparotomy. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome


20. Leyendecker JR, Gakhal M, Elsayes KM, McDermott R, Narra VR, Brown JJ: Fat-suppressed dynamic and delayed gadolinium-enhanced volumetric interpolated breath-hold magnetic resonance imaging of cholangiocarcinoma. J Comput Assist Tomogr; 2008 Mar-Apr;32(2):178-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-suppressed dynamic and delayed gadolinium-enhanced volumetric interpolated breath-hold magnetic resonance imaging of cholangiocarcinoma.
  • OBJECTIVE: To determine the enhancement phase providing the highest contrast-to-noise ratio (CNR) between cholangiocarcinoma and liver or portal vein on dynamic and delayed gadolinium-enhanced magnetic resonance imaging (MRI).
  • SUBJECTS AND METHODS: Precontrast, 3-phase dynamic postcontrast, and delayed postcontrast MRI of the liver was performed in 25 patients with cholangiocarcinoma and correlated with surgical findings, pathology, and other imaging studies.
  • CONCLUSION: No single phase of dynamic and delayed gadolinium-enhanced MRI demonstrates superior CNR between cholangiocarcinoma and normally enhancing liver, although the portal phase provides the best CNR between tumor and portal vein in most cases.
  • Although delayed enhancement is typical of cholangiocarcinoma, delayed imaging does not necessarily offer superior contrast between tumor and liver parenchyma compared with other phases of enhancement.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / diagnosis. Gadolinium DTPA. Image Enhancement / methods. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media / administration & dosage. Female. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Observer Variation. Portal Vein / anatomy & histology. Predictive Value of Tests. Respiration. Retrospective Studies

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  • (PMID = 18379298.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 84F6U3J2R6 / gadodiamide; K2I13DR72L / Gadolinium DTPA
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21. Naidu SG, Hara AK, Brandis AR, Stone WM: Incidence of highly important extravascular findings detected on CT angiography of the abdominal aorta and the lower extremities. AJR Am J Roentgenol; 2010 Jun;194(6):1630-4
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  • Overall, eight (3%) of the 275 patients had findings of high clinical significance that resulted in medical therapy or surgical intervention, including lung carcinoma, renal cell carcinoma, colon carcinoma, cholangiocarcinoma, and pulmonary coccidioidomycosis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Female. Humans. Incidence. Iohexol. Male. Middle Aged. Radiographic Image Interpretation, Computer-Assisted. Retrospective Studies

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  • (PMID = 20489106.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol
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22. Lepistö A, Kärkkäinen P, Järvinen HJ: Prevalence of primary sclerosing cholangitis in ulcerative colitis patients undergoing proctocolectomy and ileal pouch-anal anastomosis. Inflamm Bowel Dis; 2008 Jun;14(6):775-9
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  • [Title] Prevalence of primary sclerosing cholangitis in ulcerative colitis patients undergoing proctocolectomy and ileal pouch-anal anastomosis.
  • BACKGROUND: This study aimed to determine the prevalence of primary sclerosing cholangitis (PSC) among patients with ulcerative colitis (UC) needing proctocolectomy.
  • [MeSH-minor] Adolescent. Adult. Aged. Anal Canal / surgery. Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Biopsy. Cholangiocarcinoma / etiology. Female. Humans. Liver / pathology. Liver Transplantation. Male. Middle Aged. Pouchitis / etiology. Prevalence. Treatment Failure


23. Paik KY, Heo JS, Choi SH, Choi DW: Intraductal papillary neoplasm of the bile ducts: the clinical features and surgical outcome of 25 cases. J Surg Oncol; 2008 May 1;97(6):508-12
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  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Carcinoma, Papillary / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Cholangiocarcinoma / secondary. Cholangiocarcinoma / surgery. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Prognosis. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18314868.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Lempinen M, Isoniemi H, Mäkisalo H, Nordin A, Halme L, Arola J, Höckerstedt K, Stenman UH: Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures. J Hepatol; 2007 Nov;47(5):677-83
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  • [Title] Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures.
  • BACKGROUND/AIMS: Primary sclerosing cholangitis (PSC) is associated with a high risk of cholangiocarcinoma.
  • Our aim was to evaluate the diagnostic value of trypsinogen-1, trypsinogen-2, tumour-associated trypsin inhibitor, human chorionic gonadotropin beta and trypsin-2-alpha(1)-antitrypsin for cholangiocarcinoma and to compare them with CA19-9 and CEA.
  • METHODS: The study consisted of 84 patients with either PSC or cholangiocarcinoma or both referred for liver transplantation or other liver surgery.
  • RESULTS: Forty-six patients were transplanted due to PSC; in 3 of the explanted livers cholangiocarcinoma was found incidentally.
  • Twenty-nine of 38 patients with cholangiocarcinoma were candidates for intervention.
  • In all, 8 patients had both PSC and cholangiocarcinoma.
  • Receiver-operating characteristics curve analysis showed that serum trypsinogen-2 had the highest accuracy in differentiating between cholangiocarcinoma and PSC.
  • Serum trypsinogen-2 also showed the highest accuracy for differentiation between PSC and PSC with simultaneous cholangiocarcinoma with an AUC value of 0.759.
  • CONCLUSIONS: Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA.
  • [MeSH-major] Bile Duct Neoplasms / blood. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / blood. Cholangiocarcinoma / blood. Cholangiocarcinoma / diagnosis. Trypsin / blood. Trypsinogen / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. CA-19-9 Antigen / analysis. CA-19-9 Antigen / blood. Constriction, Pathologic / etiology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Receptors, Cell Surface / analysis. Receptors, Cell Surface / blood. Sensitivity and Specificity

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  • (PMID = 17640760.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Receptors, Cell Surface; 0 / carcinoembryonic antigen binding protein, human; 103964-84-7 / PRSS2 protein, human; 9002-08-8 / Trypsinogen; EC 3.4.21.4 / Trypsin
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25. Hellmann S, Schafmayer C, Hinz S, Schniewind B, Tepel J, Broering DC, Egberts JH: Evaluation of the POSSUM score in surgical treatment of cholangiocarcinoma. Hepatogastroenterology; 2010 May-Jun;57(99-100):403-8
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  • [Title] Evaluation of the POSSUM score in surgical treatment of cholangiocarcinoma.
  • BACKGROUND/AIMS: The surgical treatment for cholangiocarcinoma (CCC) is still a challenge.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery. Postoperative Complications / mortality
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Morbidity. Risk Factors. Severity of Illness Index

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  • (PMID = 20698198.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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26. Tse RV, Hawkins M, Lockwood G, Kim JJ, Cummings B, Knox J, Sherman M, Dawson LA: Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Clin Oncol; 2008 Feb 1;26(4):657-64
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  • [Title] Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
  • PURPOSE: To report outcomes of a phase I study of individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC).
  • [MeSH-major] Carcinoma, Hepatocellular / radiotherapy. Cholangiocarcinoma / radiotherapy. Liver Neoplasms / radiotherapy. Radiosurgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Gastrointestinal Hemorrhage / etiology. Humans. Intestinal Obstruction / etiology. Male. Middle Aged. Radiation Injuries / etiology. Radiotherapy Dosage. Survival Rate. Treatment Outcome

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  • [ErratumIn] J Clin Oncol. 2008 Aug 10;26(23):3911-2
  • (PMID = 18172187.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Benhamouche S, Curto M, Saotome I, Gladden AB, Liu CH, Giovannini M, McClatchey AI: Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev; 2010 Aug 15;24(16):1718-30
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  • We report here that liver-specific deletion of the neurofibromatosis type 2 (Nf2) tumor suppressor gene in the developing or adult mouse specifically yields a dramatic, progressive expansion of progenitor cells throughout the liver without affecting differentiated hepatocytes.
  • All surviving mice eventually developed both cholangiocellular and hepatocellular carcinoma, suggesting that Nf2(-/-) progenitors can be a cell of origin for these tumors.


28. Axelrod D, Koffron A, Kulik L, Al-Saden P, Mulcahy M, Baker T, Fryer J, Abecassis M: Living donor liver transplant for malignancy. Transplantation; 2005 Feb 15;79(3):363-6
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  • Adult-to-adult living donor liver transplantation (ALDLT) is being increasingly utilized to treat patients with locally advanced hepatocellular carcinoma and cholangiocarcinoma who are not prioritized under the MELD allocation system.
  • Since 1997, 18 ALDLTs have been performed for malignancy as the primary indication.
  • Five patients were transplanted for cholangiocarcinoma, with a 100% recurrence free survival at a mean follow up of 18 months among patients given neo-adjuvant chemoradiation.
  • The use of ALDLT for cholangiocarcinoma appears promising specifically in the context of neo-adjuvant therapy.
  • [MeSH-minor] Adult. Cholangiopancreatography, Endoscopic Retrograde. Female. Follow-Up Studies. Hepatitis C / surgery. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis. Treatment Outcome


29. Uenishi T, Yamazaki O, Yamamoto T, Hirohashi K, Tanaka H, Tanaka S, Hai S, Kubo S: Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg; 2005;12(6):479-83
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  • [Title] Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma.
  • BACKGROUND/PURPOSE: The Liver Cancer Study Group of Japan established a tumor-nodule-metastasis (TNM) staging system for mass-forming intrahepatic cholangiocarcinoma, with T determined by tumor number and size and vascular or serosal invasion.
  • METHODS: Sixty-three patients who underwent hepatic resection for mass-forming intrahepatic cholangiocarcinoma were investigated retrospectively, with the investigation including univariate and multivariate analyses of potential prognostic factors.
  • CONCLUSIONS: Serosal invasion showed no survival impact after hepatic resection for mass-forming intrahepatic cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 16365823.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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30. Okabe H, Beppu T, Hayashi H, Horino K, Masuda T, Komori H, Ishikawa S, Watanabe M, Takamori H, Iyama K, Baba H: Hepatic stellate cells may relate to progression of intrahepatic cholangiocarcinoma. Ann Surg Oncol; 2009 Sep;16(9):2555-64
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  • [Title] Hepatic stellate cells may relate to progression of intrahepatic cholangiocarcinoma.
  • BACKGROUND: Although cumulative evidence supports the fact that stromal myofibroblasts promote tumor progression, the influence of myofibroblasts on intrahepatic cholangiocarcinoma (ICC) is unclear.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Hepatic Stellate Cells / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Line, Tumor. Cell Proliferation. Desmin / metabolism. Disease Progression. Female. Fluorescent Antibody Technique. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunoenzyme Techniques. Liver Cirrhosis / metabolism. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Stromal Cells / metabolism. Survival Rate

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  • (PMID = 19548033.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein
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31. Lin G, Toh CH, Wu RC, Ko SF, Ng SH, Chou WC, Tseng JH: Combined hepatocellular cholangiocarcinoma: prognostic factors investigated by computed tomography/magnetic resonance imaging. Int J Clin Pract; 2008 Aug;62(8):1199-205
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  • [Title] Combined hepatocellular cholangiocarcinoma: prognostic factors investigated by computed tomography/magnetic resonance imaging.
  • This study was designed to assess the clinical usefulness of imaging for predicting the prognosis of patients with combined hepatocellular cholangiocarcinoma (cHCC-CC).
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology. Magnetic Resonance Imaging / standards. Neoplasms, Multiple Primary / pathology. Tomography, X-Ray Computed / standards
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Survival Analysis. Survival Rate

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  • (PMID = 17537192.001).
  • [ISSN] 1742-1241
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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32. Urahashi T, Yamamoto M, Ohtsubo T, Katsuragawa H, Katagiri S, Takasaki K: Hepatopancreatoduodenectomy could be allowed for patients with advanced intrahepatic cholangiocarcinoma. Hepatogastroenterology; 2007 Mar;54(74):346-9
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  • [Title] Hepatopancreatoduodenectomy could be allowed for patients with advanced intrahepatic cholangiocarcinoma.
  • BACKGROUND/AIMS: Patients with advanced intrahepatic cholangiocarcinoma (ICC) have a poor outcome even if they undergo extended radical surgery.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Hepatectomy. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Survival Rate

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  • (PMID = 17523271.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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33. Intapan PM, Tantrawatpan C, Maleewong W, Wongkham S, Wongkham C, Nakashima K: Potent epitopes derived from Fasciola gigantica cathepsin L1 in peptide-based immunoassay for the serodiagnosis of human fascioliasis. Diagn Microbiol Infect Dis; 2005 Oct;53(2):125-9
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  • The peptide-based ELISA was compared with an indirect ELISA with crude excretory-secretory products or with partially purified specific 27-kDa (FG27) antigen from adult F. gigantica.
  • In an analysis of the sera of 13 patients infected with F. gigantica, 212 patients with other parasitic infections, 32 patients with cholangiocarcinoma, and 57 healthy controls, the sensitivity, specificity, accuracy, and positive and negative predictive values of this peptide-based ELISA with both peptides had the same performance and were shown to be 100%, 97.3%, 97.5%, 61.9%, and 100%, respectively.

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  • (PMID = 16168617.001).
  • [ISSN] 0732-8893
  • [Journal-full-title] Diagnostic microbiology and infectious disease
  • [ISO-abbreviation] Diagn. Microbiol. Infect. Dis.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AF112566/ AF239264/ AF239267
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Helminth; 0 / Epitopes; EC 3.4.- / Cathepsins; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.15 / CTSL1 protein, human; EC 3.4.22.15 / Cathepsin L
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34. Konstadoulakis MM, Roayaie S, Gomatos IP, Labow D, Fiel MI, Miller CM, Schwartz ME: Aggressive surgical resection for hilar cholangiocarcinoma: is it justified? Audit of a single center's experience. Am J Surg; 2008 Aug;196(2):160-9
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  • [Title] Aggressive surgical resection for hilar cholangiocarcinoma: is it justified? Audit of a single center's experience.
  • BACKGROUND: The current study presents our experience with resectional surgery for patients with hilar cholangiocarcinoma (HC).
  • CONCLUSIONS: Major hepatic resections with concomitant vascular resection and reconstruction, when needed, are justified for patients with Bismuth type III and IV hilar cholangiocarcinoma with negative nodes.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery. Hepatectomy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystectomy. Female. Follow-Up Studies. Hospital Mortality. Humans. Male. Medical Audit. Middle Aged. Portal Vein / surgery. Survival Analysis. Vena Cava, Inferior / surgery

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  • (PMID = 18466862.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Fang CH, Xiang N, Fan YF, Yang J, Quan XY, Liang W, Tang HL: [The value of three-dimensional 64-multi-slices helical computer tomography on the diagnosis of diseases of digestive system]. Zhonghua Wai Ke Za Zhi; 2007 Jul 1;45(13):909-12
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  • The three-dimensionally reconstructed images of 34 cases of hepatocellular carcinoma (HCC) demonstrated no invasion of tumors into the tissues and blood vessels of 23 cases, visible invasion into portal vein and hepatic veins of 9 cases, tumor embolus in portal veins of 1 case, and arterio-venous fistula in only one case.
  • The 3D imaging of biliary passages displayed total concretion, tumor and constrictive or dilated biliary-pancreatic duct and bile duct around amphi-obstruction, which complied with the operations research of calculus of bile duct in 25 cases, cholangiocarcinoma in 5 cases, and cancer of pancreas in 5 cases.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 17953840.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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36. Liu L, Wang J, Liu B, Dai S, Wang X, Chen J, Huang L, Xiao X, He D: Serum levels of variants of transthyretin down-regulation in cholangiocarcinoma. J Cell Biochem; 2008 Jun 1;104(3):745-55
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  • [Title] Serum levels of variants of transthyretin down-regulation in cholangiocarcinoma.
  • BACKGROUND: Cholangiocarcinoma (CC) is devastating neoplasm and very few specific biomarkers could be used in clinical diagnosis.
  • [MeSH-major] Bile Duct Neoplasms / blood. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / metabolism. Cholangiocarcinoma / blood. Cholangiocarcinoma / metabolism. Gene Expression Regulation, Neoplastic. Prealbumin / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor. CA-19-9 Antigen / biosynthesis. Case-Control Studies. Female. Humans. Male. Middle Aged


37. Oh SW, Yoon YS, Shin SA: Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol; 2005 Jul 20;23(21):4742-54
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  • RESULTS: Adenocarcinoma in the colon and rectosigmoid, hepatocellular carcinoma, cholangiocarcinoma, adenocarcinoma in the prostate, renal cell carcinoma, papillary carcinoma in the thyroid, small-cell carcinoma in the lung, non-Hodgkin's lymphoma, and melanoma had positive dose-dependent relationships with BMI (all P < .05).
  • [MeSH-minor] Adult. Body Mass Index. Follow-Up Studies. Humans. Korea / epidemiology. Male. Proportional Hazards Models

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  • (PMID = 16034050.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Shinohara ET, Mitra N, Guo M, Metz JM: Radiation therapy is associated with improved survival in the adjuvant and definitive treatment of intrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys; 2008 Dec 1;72(5):1495-501
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  • [Title] Radiation therapy is associated with improved survival in the adjuvant and definitive treatment of intrahepatic cholangiocarcinoma.
  • The primary endpoint was overall survival (OS).
  • [MeSH-major] Bile Duct Neoplasms / radiotherapy. Cholangiocarcinoma / radiotherapy. Liver Neoplasms / radiotherapy
  • [MeSH-minor] Adult. African Continental Ancestry Group. Aged. Aged, 80 and over. European Continental Ancestry Group. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Survivors. Young Adult

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  • (PMID = 18472359.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / PHS HHS / / P30-CAO16520
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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39. Hwang DW, Lim CS, Jang JY, Lee SE, Yoon SO, Jeon YK, Uk Lee K, Kim SW: Primary hematolymphoid malignancies involving the extrahepatic bile duct or gallbladder. Leuk Lymphoma; 2010 Jul;51(7):1278-87
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  • [Title] Primary hematolymphoid malignancies involving the extrahepatic bile duct or gallbladder.
  • Primary hematolymphoid malignancies of the extrahepatic biliary tract are rare tumors.
  • We report five cases of primary hematolymphoid malignancies involving the extrahepatic biliary tract.
  • Although a preoperative diagnosis of primary hematolymphoid malignancy is very difficult to reach because of the rarity of this disease, it should be considered, because, if an accurate diagnosis is made before surgical intervention, chemotherapy is the most appropriate treatment.
  • In limited cases mimicking cholangiocarcinoma and gallbladder cancer, surgical resection followed by chemotherapy has a valid role as reasonable treatment for patients.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 20572800.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Chryssou E, Guthrie JA, Ward J, Robinson PJ: Hilar cholangiocarcinoma: MR correlation with surgical and histological findings. Clin Radiol; 2010 Oct;65(10):781-8
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  • [Title] Hilar cholangiocarcinoma: MR correlation with surgical and histological findings.
  • AIM: To evaluate magnetic resonance cholangiography (MRC) with high-resolution dynamic gadolinium-enhanced magnetic resonance imaging (MRI) in determining the imaging features of hilar cholangiocarcinoma that relate to tumour extent and influence resectability.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Hepatic Artery. Magnetic Resonance Imaging / methods. Portal Vein
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Image Interpretation, Computer-Assisted. Male. Middle Aged. Stents

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  • [Copyright] Copyright (c) 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20797463.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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41. Yamada M, Shiroeda H, Shiroeda S, Sato K, Arisawa T, Tsutsumi M: Cholangiocarcinoma producing parathyroid hormone-related peptide treated with chemoradiation using gemcitabine and S-1. Intern Med; 2009;48(24):2097-100
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  • [Title] Cholangiocarcinoma producing parathyroid hormone-related peptide treated with chemoradiation using gemcitabine and S-1.
  • Although chemotherapy for cholangiocellular carcinoma (CCC) is administered to those patients who are inoperable, the results are largely disappointing, especially for CCC producing parathyroid hormone-related peptide (PTHrP).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols. Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / drug therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Drug Combinations. Humans. Male. Oxonic Acid / therapeutic use. Parathyroid Hormone-Related Protein / metabolism. Radiotherapy, Adjuvant. Tegafur / therapeutic use

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  • (PMID = 20009399.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Parathyroid Hormone-Related Protein; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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42. Wakasa T, Wakasa K, Shutou T, Hai S, Kubo S, Hirohashi K, Umeshita K, Monden M: A histopathological study on combined hepatocellular and cholangiocarcinoma: cholangiocarcinoma component is originated from hepatocellular carcinoma. Hepatogastroenterology; 2007 Mar;54(74):508-13
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  • [Title] A histopathological study on combined hepatocellular and cholangiocarcinoma: cholangiocarcinoma component is originated from hepatocellular carcinoma.
  • BACKGROUND/AIMS: Combined hepatocellular and cholangiocarcinoma of the liver is relatively infrequent, and its pathogenesis remains obscure.
  • METHODOLOGY: In this study, we investigated the histopathological features, Ki-67 labeling index, and p53 immunohistochemistry of 18 surgically resected cases of combined hepatocellular and cholangiocarcinoma among 1102 consecutive cases of surgically resected primary liver cancers.
  • Microscopically, we classified the cases into the following three categories according to the arrangement of the hepatocellular carcinoma and cholangiocarcinoma components;.
  • (1) Type I in which hepatocellular carcinoma and cholangiocarcinoma formed nodules that could easily be distinguished from each other, (2) Type II in which the both components were finely mixed, so that the two components were almost indistinguishable, and (3) Type III in which the tumors had lobular structures with hepatocellular carcinomas existing centrally and cholangiocarcinomas existing peripherally.
  • In one case of type I, well differentiated hepatocellular carcinoma demonstrated cholangiocarcinoma in "nodules-in-nodules" fashion.
  • The average of Ki-67 labeling index of hepatocellular carcinoma component of combined hepatocellular and cholangiocarcinoma was 4.4 +/- 3.4% and the index of cholangiocarcinoma component was 11.0 +/- 8.5%, which is significantly higher than that of the hepatocellular carcinoma component.
  • In one case, the cholangiocarcinoma component was positive for p53, but the hepatocellular carcinoma component was negative.
  • In the other 4 cases, both the hepatocellular carcinoma and cholangiocarcinoma components were positive.
  • Metaplasia of hepatocellular carcinoma to intrahepatic cholangiocarcinoma is assumed to be one of the pathogenic pathways of combined hepatocellular and cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adult. Aged. Cell Division / physiology. Cell Transformation, Neoplastic / pathology. Female. Hepatitis B, Chronic / pathology. Hepatitis C, Chronic / pathology. Humans. Immunoenzyme Techniques. Ki-67 Antigen / analysis. Liver / pathology. Male. Metaplasia. Middle Aged. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 17523309.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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43. Chinnasri P, Pairojkul C, Jearanaikoon P, Sripa B, Bhudhisawasdi V, Tantimavanich S, Limpaiboon T: Preferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke-related cholangiocarcinoma. Hum Pathol; 2009 Jun;40(6):817-26
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  • [Title] Preferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke-related cholangiocarcinoma.
  • Cholangiocarcinoma in northeast Thailand is associated with liver fluke infection.
  • Mechanisms of inactivation of the p15(INK4b), p16(INK4a), and p14(ARF) have been reported in many human cancers but have not hitherto been studied in liver fluke-related cholangiocarcinoma, particularly genetic and epigenetic effects on protein expression.
  • We investigated loss of heterozygosity and microsatellite instability and performed fine mapping of the chromosomal region 9p21-pter in 94 microdissected cholangiocarcinoma samples using polymerase chain reaction based-microsatellite markers.
  • In conclusion, mechanisms of inactivation of p14(ARF), p15(INK4b), and p16(INK4a) in liver fluke-related cholangiocarcinoma are preferentially different, by which epigenetic event being the main mechanism of p14(ARF), whereas p16(INK4a) and p15(INK4b) inactivation occurs through genetic and both genetic and epigenetic events, respectively.
  • [MeSH-major] Cholangiocarcinoma / genetics. Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Fascioliasis / complications. Gene Silencing / physiology. Genes, p16 / physiology. Tumor Suppressor Protein p14ARF / genetics
  • [MeSH-minor] Adult. Aged. Chromosome Mapping. DNA Methylation. Epigenesis, Genetic. Female. Humans. Immunohistochemistry. Loss of Heterozygosity. Male. Microsatellite Instability. Middle Aged. Multigene Family. Prognosis

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  • (PMID = 19200577.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF
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44. Allam N, Khalaf H, Fagih M, Al-Sebayel M: Liver transplant for hepatocellular carcinoma: experience in a Saudi population. Exp Clin Transplant; 2008 Mar;6(1):14-24
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  • [Title] Liver transplant for hepatocellular carcinoma: experience in a Saudi population.
  • OBJECTIVES: We present our experience with deceased-donor liver transplant and living-donor liver transplant for hepatocellular carcinoma.
  • Twenty-three patients had hepatocellular carcinoma (14 deceased-donor liver transplants and 9 living-donor liver transplants).
  • Histopathology revealed incidental cholangiocarcinoma in 2 patients and a hepatoblastoma in 1.
  • Two patients died of primary graft nonfunction within 1 week of the transplant.
  • Three had tumor recurrence at 10, 13, and 18 months after transplant; 2 of these occurred in patients with cholangiocarcinoma.
  • CONCLUSIONS: In our small experience, deceased-donor liver transplant and living-donor liver transplant for hepatocellular carcinoma showed good long-term outcomes.
  • Liver transplant for hepatocellular carcinoma accompanying cholangiocarcinoma had a poor outcome with late tumor recurrence.
  • Use of marginal donors in patients with hepatocellular carcinoma might compromise the outcome in these patients.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery. Liver Transplantation
  • [MeSH-minor] Adolescent. Adult. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cadaver. Child. Child, Preschool. Cholangiocarcinoma / pathology. Disease-Free Survival. Female. Follow-Up Studies. Graft Survival. Humans. Living Donors. Male. Middle Aged. Neoplasm Recurrence, Local. Saudi Arabia. Survival Rate. alpha-Fetoproteins / analysis

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  • (PMID = 18405240.001).
  • [ISSN] 1304-0855
  • [Journal-full-title] Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
  • [ISO-abbreviation] Exp Clin Transplant
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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45. Crowe DR, Eloubeidi MA, Chhieng DC, Jhala NC, Jhala D, Eltoum IA: Fine-needle aspiration biopsy of hepatic lesions: computerized tomographic-guided versus endoscopic ultrasound-guided FNA. Cancer; 2006 Jun 25;108(3):180-5
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  • In both groups the primary clinical indication was suspected metastatic carcinoma (CT, 41% of cases vs. EUS, 56%).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / radiography. Carcinoma, Hepatocellular / ultrasonography. Carcinoma, Neuroendocrine / pathology. Carcinoma, Neuroendocrine / radiography. Carcinoma, Neuroendocrine / ultrasonography. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Carcinoma, Squamous Cell / ultrasonography. Cholangiocarcinoma / pathology. Cholangiocarcinoma / radiography. Cholangiocarcinoma / ultrasonography. Female. Humans. Liver / pathology. Liver / radiography. Liver / ultrasonography. Male. Middle Aged. Tomography, X-Ray Computed


46. Okamura Y, Harada A, Maeda A, Fujioka A, Horiba T, Ishigure K, Hirai A, Ito Y, Uesaka K: Carcinomatous meningitis secondary to cholangiocarcinoma without other systemic metastasis. J Hepatobiliary Pancreat Surg; 2008;15(2):237-9
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  • [Title] Carcinomatous meningitis secondary to cholangiocarcinoma without other systemic metastasis.
  • It occurs in about 5% of all adult cancer patients, though autopsies may double this number.
  • The primary tumors that frequently cause carcinomatous meningitis include lung cancer, breast cancer, leukemia, lymphoma, and melanoma.
  • Carcinomatous meningitis secondary to primary tumors in the gastrointestinal tract is clinically infrequent.
  • In this report, we describe a 73-year-old man with lower bile duct cancer, who developed carcinomatous meningitis following surgical resection of the primary cancer.
  • To our knowledge, this is the third case of carcinomatous meningitis secondary to cholangiocarcinoma described in the literature so far.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / secondary. Meningeal Neoplasms / secondary. Meningitis / etiology

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  • (PMID = 18392723.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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47. Harewood GC, Baron TH, Rumalla A, Wang KK, Gores GJ, Stadheim LM, de Groen PC: Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma. J Gastroenterol Hepatol; 2005 Mar;20(3):415-20
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  • [Title] Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma.
  • BACKGROUND: Photodynamic therapy (PDT) has demonstrated promise in the palliative treatment of advanced cholangiocarcinoma.
  • The aim of this pilot study was to assess the outcome in patients with non-resectable cholangiocarcinoma following endoscopic application of PDT directly into the biliary tract.
  • METHODS: In patients with advanced cholangiocarcinoma, endoscopic retrograde cholangiopancreatography (ERCP) was performed to define the proximal and distal extent of intraductal tumor.
  • Eight patients with advanced cholangiocarcinoma received a total of 19 PDT treatments, range 1-5 treatments/patient.
  • CONCLUSIONS: Endoscopic application of PDT demonstrates promise in prolonging survival in patients with advanced cholangiocarcinoma.
  • Additional randomized clinical trials using commercially available fibers are needed to fully evaluate both the optimum frequency and treatment interval of endoscopic PDT in the management of advanced cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / therapy. Cholangiopancreatography, Endoscopic Retrograde / methods. Photochemotherapy / methods
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Cell Line, Tumor. Dihematoporphyrin Ether / administration & dosage. Dihematoporphyrin Ether / therapeutic use. Follow-Up Studies. Humans. Laser Therapy. Middle Aged. Pilot Projects. Prosthesis Implantation / instrumentation. Retrospective Studies. Stents. Survival Rate. Treatment Outcome

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  • (PMID = 15740486.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 97067-70-4 / Dihematoporphyrin Ether
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48. Tsalis K, Vasiliadis K, Kalpakidis V, Christoforidis E, Avgerinos A, Botsios D, Megalopoulos A, Haidich AB, Betsis D: A single-center experience in the management of Altemeier-Klatskin tumors. J Gastrointestin Liver Dis; 2007 Dec;16(4):383-9
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  • METHODS: Over a 15-year period, 37 patients with hilar cholangiocarcinoma were managed in our Department.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical / methods. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Female. Follow-Up Studies. Hepatic Duct, Common. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18193119.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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49. Wang M, Gong B, Li Y, Wang Y: Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance. Hematol Oncol Stem Cell Ther; 2010;3(2):66-70
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  • [Title] Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance.
  • We evaluated the expression and clinicopathological significance of the human G protein gamma 7 (G-gamma 7) in human extra-hepatic cholangiocarcinoma (EHCC).
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Biomarkers, Tumor / biosynthesis. Cholangiocarcinoma / metabolism. Gene Expression Regulation, Neoplastic. Heterotrimeric GTP-Binding Proteins / biosynthesis. Neoplasm Proteins / biosynthesis. Precancerous Conditions / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Prognosis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20543539.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.6.5.1 / Heterotrimeric GTP-Binding Proteins
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50. Tamandl D, Kaczirek K, Gruenberger B, Koelblinger C, Maresch J, Jakesz R, Gruenberger T: Lymph node ratio after curative surgery for intrahepatic cholangiocarcinoma. Br J Surg; 2009 Aug;96(8):919-25
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  • [Title] Lymph node ratio after curative surgery for intrahepatic cholangiocarcinoma.
  • BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is rare but its incidence is rising worldwide.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic / surgery. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Lymph Node Excision / mortality. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local / etiology. Retrospective Studies

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  • [Copyright] Copyright 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 19591163.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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51. Stavropoulos S, Larghi A, Verna E, Battezzati P, Stevens P: Intraductal ultrasound for the evaluation of patients with biliary strictures and no abdominal mass on computed tomography. Endoscopy; 2005 Aug;37(8):715-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / complications. Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Cholangiopancreatography, Endoscopic Retrograde. Constriction, Pathologic. Humans. Male. Middle Aged. Pancreatic Neoplasms / complications. Sensitivity and Specificity

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  • (PMID = 16032489.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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52. Xu MJ, Liu Q, Nisbet AJ, Cai XQ, Yan C, Lin RQ, Yuan ZG, Song HQ, He XH, Zhu XQ: Identification and characterization of microRNAs in Clonorchis sinensis of human health significance. BMC Genomics; 2010;11:521
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  • BACKGROUND: Clonorchis sinensis is a zoonotic parasite causing clonorchiasis-associated human disease such as biliary calculi, cholecystitis, liver cirrhosis, and it is currently classified as carcinogenic to humans for cholangiocarcinoma.
  • To identify and characterize miRNAs expressed in adult C. sinensis residing chronically in the biliary tract, we developed an integrative approach combining deep sequencing and bioinformatic predictions with stem-loop real-time PCR analysis.

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  • (PMID = 20920166.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Helminth
  • [Other-IDs] NLM/ PMC3224684
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53. Man XB, Tang L, Zhang BH, Li SJ, Qiu XH, Wu MC, Wang HY: Upregulation of Glypican-3 expression in hepatocellular carcinoma but downregulation in cholangiocarcinoma indicates its differential diagnosis value in primary liver cancers. Liver Int; 2005 Oct;25(5):962-6
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  • [Title] Upregulation of Glypican-3 expression in hepatocellular carcinoma but downregulation in cholangiocarcinoma indicates its differential diagnosis value in primary liver cancers.
  • BACKGROUND/AIM: Expression alteration of Glypican-3 (GPC3) is associated with several malignancies and has been identified as an overexpressed gene in hepatocellular carcinoma (HCC).
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Carcinoma, Hepatocellular / metabolism. Cholangiocarcinoma / metabolism. Liver Neoplasms / metabolism. Membrane Proteins / genetics. Neoplasm Proteins / genetics
  • [MeSH-minor] Adult. Aged. Bile Ducts, Intrahepatic. Diagnosis, Differential. Female. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Glypicans. Humans. Male. Middle Aged

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  • (PMID = 16162153.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GPC3 protein, human; 0 / Glypicans; 0 / Membrane Proteins; 0 / Neoplasm Proteins
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54. Wiseman K, Buczkowski AK, Chung SW, Francoeur J, Schaeffer D, Scudamore CH: Epidemiology, presentation, diagnosis, and outcomes of choledochal cysts in adults in an urban environment. Am J Surg; 2005 May;189(5):527-31; discussion 531
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  • No patient developed cholangiocarcinoma after complete resection of their cyst.
  • [MeSH-minor] Adult. British Columbia / epidemiology. Diagnosis, Differential. Female. Humans. Incidence. Male. Retrospective Studies. Urban Population

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  • (PMID = 15862490.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Abraham SC, Kamath PS, Eghtesad B, Demetris AJ, Krasinskas AM: Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. Am J Surg Pathol; 2006 Nov;30(11):1454-61
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  • Most patients undergoing OLT for chronic biliary tract disease have end-stage liver disease associated with cirrhosis, but a minority are transplanted in the precirrhotic stage for indications that can include poor quality of life (eg, intractable pruritus or fatigue), recurrent ascending cholangitis, or cholangiocarcinoma.
  • The following clinical data were recorded: age, sex, type of biliary tract disease, radiology, clinical symptoms, signs of portal hypertension, pretransplant shunting procedures, time between diagnosis and OLT, and primary indication for OLT.
  • Underlying biliary tract disease included primary sclerosing cholangitis (18 cases), primary biliary cirrhosis (5 cases), autoimmune cholangitis (2 cases), and secondary sclerosing cholangitis (1 case).
  • Primary indications for OLT were recurrent cholangitis and/or decreased quality of life (11 cases), complications of portal hypertension (6 cases), portal hypertension plus cholangitis/decreased quality of life (5 cases), and malignancy (4 cases).
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Hyperplasia. Liver / blood supply. Liver Neoplasms / surgery. Male. Middle Aged. Quality of Life


56. Dinant S, Gerhards MF, Rauws EA, Busch OR, Gouma DJ, van Gulik TM: Improved outcome of resection of hilar cholangiocarcinoma (Klatskin tumor). Ann Surg Oncol; 2006 Jun;13(6):872-80
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  • [Title] Improved outcome of resection of hilar cholangiocarcinoma (Klatskin tumor).
  • BACKGROUND: Treatment of hilar cholangiocarcinoma (Klatskin tumors) has changed in many aspects.
  • METHODS: A total of 99 consecutive patients underwent resection for hilar cholangiocarcinoma in three 5-year time periods: periods 1 (1988-1993; n=45), 2 (1993-1998; n=25), and 3 (1998-2003; n=29).
  • [MeSH-major] Bile Duct Neoplasms / surgery. Biliary Tract Surgical Procedures. Cholangiocarcinoma / surgery. Hepatic Duct, Common / surgery. Klatskin Tumor / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hepatectomy. Humans. Lymph Nodes / pathology. Male. Middle Aged. Palliative Care. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 16614876.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Mondragón-Sánchez R, Murrieta-González H, Martínez-González MN, Gómez-Gómez E, Arias-Arias O, Mondragón-Sánchez A, Bernal-Maldonado R, Jasso-Barranco R: [Ablation of malignant liver tumors with radiofrequency. A series of cases in Mexico.]. Rev Gastroenterol Mex; 2009;74(3):212-7
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  • BACKGROUND: Surgical resection is the treatment of choice for most of the primary and secondary liver tumors, unfortunately, many patients are not suitable for resection.
  • Histologic type was as follows: 18 hepatocellular carcinomas; 10 metastatic tumors (four breast, four colorectal and two neuro- endocrine); one gallbladder carcinoma and one peripheral cholangiocarcinoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Female. Humans. Liver Cirrhosis / etiology. Liver Cirrhosis / surgery. Male. Mexico / epidemiology. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 19858009.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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58. Taweevisit M, Chirakalwasan N, Pumsuk U, Keelawat S, Shuangshoti S: Metastatic adenocarcinoma to the cervical lymph node: a significant proportion of cholangiocarcinoma in Thai patients. Asian Pac J Cancer Prev; 2008 Jan-Mar;9(1):39-41
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  • [Title] Metastatic adenocarcinoma to the cervical lymph node: a significant proportion of cholangiocarcinoma in Thai patients.
  • OBJECTIVE: To determine distribution of the primary site of metastatic adenocarcinoma to the cervical lymph node in Thai population with histological correlation.
  • RESULTS: Thyroid gland (papillary carcinoma) was the commonest source of tumor (41%), followed by lung (25%), bile duct (17%) and breast (7%).
  • Metastatic cholangiocarcinoma typically produced distinct glandular pattern, and frequently involved the right supraclavicular lymph node.
  • Brush border of the gland-forming tumor cells was a consistent finding in metastatic cholangiocarcinoma, with 100% sensitivity and 97% specificity.
  • CONCLUSIONS: Cholangiocarcinoma represents a significant portion of primary tumor in Thai patients with cervical nodal metastasis.
  • This figure may hold true for countries where bile duct malignancy is endemic, and may be of clinical usefulness in identification of primary cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / secondary. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lung Neoplasms / pathology. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Retrospective Studies. Thailand. Thyroid Neoplasms / pathology. Young Adult

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  • (PMID = 18439070.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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59. Kim JY, Kang DH, Kim HW, Choi CW, Kim ID, Hwang JH, Kim DU, Eum JS, Bae YM: Usefulness of slimmer and open-cell-design stents for endoscopic bilateral stenting and endoscopic revision in patients with hilar cholangiocarcinoma (with video). Gastrointest Endosc; 2009 Dec;70(6):1109-15
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  • [Title] Usefulness of slimmer and open-cell-design stents for endoscopic bilateral stenting and endoscopic revision in patients with hilar cholangiocarcinoma (with video).
  • BACKGROUND: Although endoscopic bilateral metal stenting using a "stent-in-stent" method is currently used to treat patients with unresectable hilar cholangiocarcinoma, this method has limited application in cases of tight strictures or endoscopic revision in case of tumor recurrence, especially on the first stent (initial Y stent placed) side.
  • PATIENTS: This study involved 34 patients with unresectable hilar cholangiocarcinoma (Bismuth type II-IV).
  • CONCLUSION: A slimmer (7F), open-cell-design stent is effective in endoscopic bilateral stenting for advanced hilar cholangiocarcinoma and endoscopic revision in case of tumor recurrence.
  • [MeSH-major] Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / therapy. Stents
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Endoscopy, Digestive System. Equipment Design. Female. Humans. Male. Metals. Middle Aged. Prospective Studies. Prosthesis Implantation / methods

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  • (PMID = 19647244.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metals
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60. Vullierme MP, Vilgrain V: [Isolated or multifocal segmental intrahepatic bile duct dilatation: management]. J Radiol; 2006 Apr;87(4 Pt 2):500-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Bile Duct Neoplasms / diagnosis. Caroli Disease / diagnosis. Caroli Disease / radiography. Cholangiocarcinoma / diagnosis. Cholangitis, Sclerosing / diagnosis. Cholangitis, Sclerosing / radiography. Cholangitis, Sclerosing / ultrasonography. Cholecystectomy. Diagnosis, Differential. Echinococcosis, Hepatic / diagnosis. Female. Humans. Liver Neoplasms / diagnosis. Male. Middle Aged. Mutation. Tomography, X-Ray Computed

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  • (PMID = 16691179.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 25
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61. Li Q, Wang JM, Liu C, Xiao BL, Su Y, Zou SQ: [Expression and significance of aPKC-iota and E-cadherin in cholangiocarcinoma]. Ai Zheng; 2007 Jul;26(7):715-8
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  • [Title] [Expression and significance of aPKC-iota and E-cadherin in cholangiocarcinoma].
  • This study was to investigate the expression of aPKC-iota and E-cadherin in cholangiocarcinoma, and analyze molecular mechanisms of the invasion and metastasis of cholangiocarcinoma.
  • METHODS: The expression of aPKC-iota and E-cadherin in 9 specimens of benign bile duct tissues and 35 specimens of cholangiocarcinoma was detected by EnVision immunohistochemistry, and their correlations to the clinicopathologic characteristics and invasion of cholangiocarcinoma were analyzed.
  • RESULTS: The positive rate of aPKC-iota was significantly higher in cholangiocarcinoma than in benign bile duct tissues (68.6% vs. 11.1%, P = 0.006), while the positive rate of E-cadherin was significantly lower in cholangiocarcinoma than in benign bile duct tissues (37.1% vs. 88.9%, P = 0.016).
  • aPKC-iota expression was positively and E-cadherin expression was negatively correlated to the differentiation and invasion of cholangiocarcinoma (P < 0.05).
  • CONCLUSIONS: The expression of aPKC-iota and E-cadherin may reflect the differentiation and invasive potential of cholangiocarcinoma.
  • As a polar regulation-associated protein, aPKC-iota may play a role in the invasion and metastasis of cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic. Cadherins / metabolism. Cholangiocarcinoma / metabolism. Isoenzymes / metabolism. Protein Kinase C / metabolism
  • [MeSH-minor] Adult. Aged. Bile Ducts / metabolism. Cell Differentiation. Cholangitis / metabolism. Choledochal Cyst / metabolism. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Young Adult

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  • (PMID = 17626746.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins; 0 / Isoenzymes; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / protein kinase C lambda
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62. Mourad W, Khalaf H, Tulbah A, Al Omari M, Al Mana H, Neimatallah M: Clinicopathologic features of hepatic neoplasms in explanted livers: a single institution experience. Ann Saudi Med; 2007 Nov-Dec;27(6):437-41
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  • BACKGROUND: Hepatic neoplasms can be the primary indication for hepatic transplantation.
  • The primary etiology of hepatic disease was hepatitis C virus in 12 cases, hepatitis B virus in 1 case, cryptigenic cirrhosis in 1 case and congenital hepatic fibrosis in 1 case.
  • The tumors included hepatocellular carcinoma (HCC) in 13 cases, 1 case of choloangiocarcinoma and 1 case of combined HCC and hepatoblastoma.
  • [MeSH-minor] Adolescent. Adult. CA-19-9 Antigen / blood. Carcinoma, Hepatocellular / etiology. Carcinoma, Hepatocellular / pathology. Child. Child, Preschool. Cholangiocarcinoma / etiology. Cholangiocarcinoma / pathology. Female. Follow-Up Studies. Gene Expression. Hepatitis B / complications. Hepatitis C / complications. Hepatoblastoma / etiology. Hepatoblastoma / pathology. Humans. Liver Cirrhosis / complications. Male. Middle Aged. alpha-Fetoproteins / analysis

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  • (PMID = 18059117.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / CA-19-9 Antigen; 0 / alpha-Fetoproteins
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63. Chen PH, Lin YC, Tu HP, Chiang SL, Ko AM, Hsu CL, Chang YF, Ko YC: Important prognostic factors for the long-term survival of subjects with primary liver cancer in Taiwan: a hyperendemic area. Eur J Cancer; 2007 Apr;43(6):1076-84
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  • [Title] Important prognostic factors for the long-term survival of subjects with primary liver cancer in Taiwan: a hyperendemic area.
  • This study used a large-scale cancer database in determining the survival prognostic factors among primary liver cancer (PLC) subjects.
  • The prognostic indicators associated with higher risk of all-cause deaths are male gender (males versus females; HR=1.16, 95% confidence intervals (CI), 1.13-1.20), diagnosis at later period (shown in 1990-1994 versus 1985-1989; HR=1.04, 95% CI, 1.01-1.08), increasing age at diagnosis, subjects with adenocarcinoma/cholangiocarcinoma (CC) and with no therapy against those with chemotherapy.
  • [MeSH-minor] Adenocarcinoma / mortality. Adult. Age Distribution. Aged. Carcinoma, Hepatocellular / mortality. Cause of Death. Cholangiocarcinoma / mortality. Female. Humans. Male. Middle Aged. Prognosis. Sex Distribution. Survival Analysis. Taiwan / epidemiology

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  • (PMID = 17329095.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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64. Costa DB, Stuart KE, Inzucchi SE: Hyperglycemia and biliary tract adenocarcinoma. J Gastroenterol Hepatol; 2006 Feb;21(2):484-5
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  • [MeSH-major] Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Biliary Tract Neoplasms / complications. Cholangiocarcinoma / complications. Hyperglycemia / complications
  • [MeSH-minor] Adult. Aged. Blood Glucose / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Risk Factors

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  • (PMID = 16509886.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Letter
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Blood Glucose
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65. Chamadol N, Laopaiboon V, Kaewradee J, Khuntikeo N, Bhudhisawasdi V, Pairojkul C: Comparison of computed tomographic finding of the intraductal and periductal cholangiocarcinoma. J Med Assoc Thai; 2010 Apr;93(4):481-8
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  • [Title] Comparison of computed tomographic finding of the intraductal and periductal cholangiocarcinoma.
  • OBJECTIVE: To compare the CT findings of the intraductal and periductal cholangiocarcinoma (CCA) in Srinagarind Hospital.
  • [MeSH-major] Bile Duct Neoplasms / radiography. Bile Ducts, Extrahepatic. Bile Ducts, Intrahepatic. Cholangiocarcinoma / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Cohort Studies. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20462093.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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66. Hänninen EL, Pech M, Jonas S, Ricke J, Thelen A, Langrehr J, Hintze R, Röttgen R, Denecke T, Winter L, Neuhaus P, Felix R: Magnetic resonance imaging including magnetic resonance cholangiopancreatography for tumor localization and therapy planning in malignant hilar obstructions. Acta Radiol; 2005 Aug;46(5):462-70
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  • MATERIAL AND METHODS: Thirty-one patients with malignant hilar obstructions (hilar cholangiocarcinoma, n=30; hepatocellular carcinoma, n=1) received MRCP by two techniques (single-shot thick-slab and multisection thin-slice MRCP) and unenhanced and contrast material-enhanced MRI.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / diagnosis. Cholangiocarcinoma / diagnosis. Cholangiopancreatography, Magnetic Resonance / methods. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adult. Aged. Artifacts. Female. Humans. Male. Middle Aged. Observer Variation. Reproducibility of Results

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  • [CommentIn] Acta Radiol. 2005 Aug;46(5):442 [16224915.001]
  • (PMID = 16224919.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Sweden
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67. Fasanella KE, Krasinskas A, Schoedel KE, Sasatomi E, Slivka A, Whitcomb DC, Sanders M, Nodit L, Raab S, McGrath KM, Ohori NP, Khalid A: DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma. Pancreatology; 2010;10(4):429-33
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  • [Title] DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma.
  • BACKGROUND/AIMS: Preoperative distinction between pancreatic cancer (PC) and extrahepatic cholangiocarcinoma (CC) is desirable due to diverging management options, and to optimize enrollment into neoadjuvant trials.
  • RESULTS: Of 33 cases studied (17 males; 16 PC, 17 CC; 10 with primary sclerosing cholangitis), a K-ras mutation was present in 14/16 (87.5%) PC and 1/17 (5.9%) CC cases (p < 0.001), sensitivity and specificity were 87.5 and 94%, respectively.
  • [MeSH-major] Bile Duct Neoplasms / genetics. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / genetics. Cholangiocarcinoma / genetics. DNA Mutational Analysis. Pancreatic Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholangitis, Sclerosing / genetics. Cholangitis, Sclerosing / pathology. DNA, Neoplasm / analysis. Female. Genes, ras / genetics. Humans. Male. Microdissection. Microsatellite Instability. Middle Aged. Mutation. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20720444.001).
  • [ISSN] 1424-3911
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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68. Kuo CM, Changchien CS, Wu KL, Chuah SK, Chiu KW, Chiu YC, Chou YP, Kuo CH: Mucin-producing cholangiocarcinoma: clinical experience of 24 cases in 16 years. Scand J Gastroenterol; 2005 Apr;40(4):455-9
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  • [Title] Mucin-producing cholangiocarcinoma: clinical experience of 24 cases in 16 years.
  • OBJECTIVE: Mucin-producing cholangiocarcinoma (MPCC) is an uncommon biliary tract malignancy.
  • MATERIAL AND METHODS: The study included 24 MPCC cases (7 M, 17 F) from 132 histopathology-proven cholangiocarcinoma patients seen between 1988 and 2003.
  • MPCC and non-mucin-producing cholangiocarcinoma (non-MPCC) were compared.
  • In detecting MPCC, a serum CA-19-9 level > 120 U/ml had 73% sensitivity, 41% specificity, 25% positive predictive value, 85% negative predictive value, and 48% accuracy in the 132 cholangiocarcinoma patients.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. CA-19-9 Antigen / blood. Cholangiocarcinoma / diagnosis. Mucins / physiology
  • [MeSH-minor] Adult. Aged. Biliary Tract Surgical Procedures. Biomarkers, Tumor / blood. Cholelithiasis / complications. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prognosis. Retrospective Studies

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  • (PMID = 16028441.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Mucins
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69. Phongkitkarun S, Srisuwan T, Sornmayura P, Jatchavala J: Combined hepatocellular and cholangiocarcinoma: CT findings with emphasis on multiphasic helical CT. J Med Assoc Thai; 2007 Jan;90(1):113-20
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  • [Title] Combined hepatocellular and cholangiocarcinoma: CT findings with emphasis on multiphasic helical CT.
  • OBJECTIVE: To describe CT findings of patients with combined hepatocellular carcinoma and cholangiocarcinoma (HCC-CC) in correlation with clinical data and histopathological results.
  • [MeSH-major] Bile Duct Neoplasms / radiography. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / radiography. Cholangiocarcinoma / radiography. Liver Neoplasms / radiography. Neoplasms, Multiple Primary / radiography. Tomography, Spiral Computed
  • [MeSH-minor] Adult. Aged. CA-19-9 Antigen / blood. Female. Humans. Male. Middle Aged. Radiographic Image Enhancement. Retrospective Studies. alpha-Fetoproteins / analysis

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  • (PMID = 17621741.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / CA-19-9 Antigen; 0 / alpha-Fetoproteins
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70. Kim JH, Yoon HK, Sung KB, Ko GY, Gwon DI, Shin JH, Song HY: Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes. Cancer; 2008 Oct 1;113(7):1614-22
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  • [Title] Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes.
  • BACKGROUND: The role of transcatheter arterial chemoembolization (TACE) or transcatheter arterial chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned.
  • [MeSH-major] Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Chemoembolization, Therapeutic / methods. Cholangiocarcinoma / therapy. Hepatic Artery. Infusions, Intra-Arterial / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis. Treatment Outcome


71. Li TY, Wang SG, Li DJ, Gao ZF, Gao YH, Jiang WW: [Effect of hepatitis C virus core protein on cholangiocarcinoma tissues' epithelial-mesenchymal transition]. Zhonghua Wai Ke Za Zhi; 2007 Nov 1;45(21):1491-3
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  • [Title] [Effect of hepatitis C virus core protein on cholangiocarcinoma tissues' epithelial-mesenchymal transition].
  • OBJECTIVE: To explore the role of hepatitis C virus core protein on the infiltration and metastasis of cholangiocarcinoma tissues.
  • METHODS: From January 2001 to November 2006, 34 patients with cholangiocarcinoma who had intact follow-up data randomly were chosen.
  • The expression of HCVc protein, epithelium markers and mesenchymal markers in cholangiocarcinoma tissues were examined by SP methods of immunohistochemistry, clinical-pathological data were recorded and analyzed.
  • CONCLUSION: HCVc protein might promote cholangiocarcinoma tissues' infiltration and metastasis by inducing it's epithelial-mesenchymal transition.
  • [MeSH-major] Cell Transformation, Neoplastic. Cholangiocarcinoma / pathology. Epithelium / pathology. Viral Core Proteins / physiology
  • [MeSH-minor] Adult. Aged. Female. Hepacivirus / metabolism. Hepatitis C / metabolism. Hepatitis C / pathology. Hepatitis C / virology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis

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  • (PMID = 18275718.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Viral Core Proteins; 0 / nucleocapsid protein, Hepatitis C virus
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72. Ishizaki Y, Yoshimoto J, Miwa K, Sugo H, Kawasaki S: Safety of prolonged intermittent pringle maneuver during hepatic resection. Arch Surg; 2006 Jul;141(7):649-53; discussion 654
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  • PATIENTS: Resections were performed for metastatic carcinoma in 19 patients, hepatocellular carcinoma in 7 patients, hilar bile duct carcinoma in 3 patients, intrahepatic cholangiocarcinoma in 1 patient, combined hepatocellular carcinoma and cholangiocarcinoma in 1 patient, undifferentiated embryonal sarcoma in 1 patient, carcinoid tumor in 1 patient, and benign mucinous cystic tumor in 1 patient.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Constriction. Female. Follow-Up Studies. Humans. Intraoperative Period. Liver Circulation. Liver Function Tests. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 16847234.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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73. Zhang TL, Ma SH, Xiu DR, Song SB, Yuan CH, Jia YM, Gong EC: [The pathological feature of primary hepatic carcinoma on explanted liver and its significance]. Zhonghua Wai Ke Za Zhi; 2010 Jul 1;48(13):964-7
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  • [Title] [The pathological feature of primary hepatic carcinoma on explanted liver and its significance].
  • OBJECTIVE: To investigate the pathological feature of primary hepatic carcinoma and the clinical significance.
  • METHODS: From August 2000 to December 2007, there were 89 patients with cirrhosis and carcinoma of liver who accepted whole liver resection.
  • RESULTS: The total of 89 cases included hepatocellular carcinoma in 86 cases and cholangiocarcinoma in 3 cases; 53 cases with multiple tumors and 36 cases with solitary tumor; complete capsule only in 14 cases, no obvious margin in 11 cases, 13 cases had a major tumor in the right lobe and a small tumor in the left lobe; 8 of 25 cases with gross invaded tissue were confirmed by histological examination, 7 of 16 cases with swollen lymph nodes were infiltrated by cancer cells.
  • CONCLUSIONS: The whole explanted liver can completely reflect the characteristics of growth and infiltration of hepatic carcinoma.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Hepatectomy. Humans. Liver / pathology. Male. Middle Aged. Young Adult

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  • (PMID = 21054976.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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74. Mulvenna J, Sripa B, Brindley PJ, Gorman J, Jones MK, Colgrave ML, Jones A, Nawaratna S, Laha T, Suttiprapa S, Smout MJ, Loukas A: The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini. Proteomics; 2010 Mar;10(5):1063-78
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  • [Title] The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini.
  • Both experimental and epidemiological evidence strongly implicate liver fluke infection in the etiology of one of the liver cancer subtypes, cholangiocarcinoma (CCA).

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  • (PMID = 20049860.001).
  • [ISSN] 1615-9861
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI065871-01; United States / NIAID NIH HHS / AI / U01 AI065871; United States / NIAID NIH HHS / AI / U01 AI065871-01; United States / NIAID NIH HHS / AI / UO1AI065871
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Helminth Proteins; 0 / Membrane Proteins; 0 / Peptides; 0 / Proteome; EC 3.4.- / Peptide Hydrolases
  • [Other-IDs] NLM/ NIHMS259436; NLM/ PMC3038172
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75. Wu F, Wu L, Zheng S, Ding W, Teng L, Wang Z, Ma Z, Zhao W: The clinical value of hepatocyte growth factor and its receptor--c-met for liver cancer patients with hepatectomy. Dig Liver Dis; 2006 Jul;38(7):490-7
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  • BACKGROUND: To study the dynamic change of hepatocyte growth factor after hepatectomy in patients with primary liver cancer, and to analyse the prognostic value of hepatocyte growth factor and c-met for these patients.
  • Serum hepatocyte growth factor level was positively affected by tumour size, node cirrhosis, portal vein tumour thrombi, cholangiocarcinoma (including combined hepatocellular carcinoma), poorly differentiated hepatocellular carcinoma and tumour recurrence or metastases.
  • C-met protein expression in cancerous tissues was correlated with portal vein tumour thrombi, cholangiocarcinoma and tumour recurrence or metastases, and the expression in paracancerous tissues was correlated with node cirrhosis.
  • [MeSH-minor] Adult. Aged. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. RNA, Messenger / genetics

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  • (PMID = 16627020.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 67256-21-7 / Hepatocyte Growth Factor; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
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76. Rau S, Autschbach F, Riedel HD, Konig J, Kulaksiz H, Stiehl A, Riemann JF, Rost D: Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas. Eur J Clin Invest; 2008 Feb;38(2):134-42
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  • [Title] Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas.
  • BACKGROUND: Cholangiocellular carcinomas and gallbladder carcinomas are highly aggressive tumours with a poor prognosis and are generally regarded as chemoresistant tumours.
  • To further define the role of MRP family members in biliary tract cancer, we studied the expression and localization of MRP2 and MRP3 in cholangiocellular carcinomas and gallbladder carcinomas.
  • MATERIALS AND METHODS: The expression and cellular localization of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas and gallbladder carcinomas were analysed by immunohistochemistry using isoform-specific antibodies.
  • MRP3 was the predominant MRP isoform in gallbladder carcinomas (93%) and cholangiocellular carcinomas (57%), whereas MRP2 expression was detected in only 29% of gallbladder carcinomas and was undetectable in cholangiocellular carcinomas.
  • CONCLUSIONS: Our findings suggest that the intrinsic multidrug resistance of cholangiocellular and gallbladder carcinomas seems to be independent of MRP2 expression while the expression of MRP3 may contribute to the MDR phenotype.
  • [MeSH-major] Cholangiocarcinoma / metabolism. Drug Resistance, Multiple / genetics. Drug Resistance, Neoplasm / genetics. Gallbladder Neoplasms / metabolism. Membrane Transport Proteins / analysis. Multidrug Resistance-Associated Proteins / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Gene Expression. Humans. Immunoblotting. Microscopy, Fluorescence. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 18226047.001).
  • [ISSN] 1365-2362
  • [Journal-full-title] European journal of clinical investigation
  • [ISO-abbreviation] Eur. J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Transport Proteins; 0 / Multidrug Resistance-Associated Proteins; 0 / multidrug resistance-associated protein 2; 0 / multidrug resistance-associated protein 3
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77. Lai EC, Lau WY: Aggressive surgical resection for hilar cholangiocarcinoma. ANZ J Surg; 2005 Nov;75(11):981-5
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  • [Title] Aggressive surgical resection for hilar cholangiocarcinoma.
  • BACKGROUND: Surgical treatment of hilar cholangiocarcinoma remains a great challenge to surgeons because of its low resectability, poor survival, and high operative mortality and morbidity.
  • METHODS: The medical and pathological records of 36 patients with a preoperative diagnosis of 'resectable' hilar cholangiocarcinoma operated on by us between January 1998 and December 2002 were studied.
  • CONCLUSIONS: Aggressive surgery increases the resectability of hilar cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Hepatectomy. Humans. Liver Transplantation. Male. Middle Aged. Retrospective Studies. Survival Rate. Transplantation, Autologous

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  • (PMID = 16336393.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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78. Ji Y, Fan J, Zhou J, Wang BS, Liu HB, Wu ZW, Tan YS: Intraductal papillary neoplasms of bile duct. A distinct entity like its counterpart in pancreas. Histol Histopathol; 2008 01;23(1):41-50
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  • Because of its distinct clinical, pathological features and a favorable prognosis can be expected after complete surgical resection, we suggested that intraductal papillary neoplasia should be distinguished from other types of peripheral cholangiocarcinoma, as a distinct entity, like its counterparts in the pancreas.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Pancreatic Neoplasms / pathology. Papilloma / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 17952856.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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79. Wu YM, Johlin FC, Rayhill SC, Jensen CS, Jin X, Mitros FA: [Long-term, tumor-free survival after radiotherapy combining hepatectomy-Whipple en bloc and orthotopic liver transplantation for early-stage hilar cholangiocarcinoma]. Zhonghua Wai Ke Za Zhi; 2009 Aug 1;47(15):1155-61
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  • [Title] [Long-term, tumor-free survival after radiotherapy combining hepatectomy-Whipple en bloc and orthotopic liver transplantation for early-stage hilar cholangiocarcinoma].
  • OBJECTIVE: To report the experience in surveillance and early detection of cholangiocarcinoma (CC) and in using en bloc total hepatectomy-pancreaticoduodenectomy-orthotopic liver transplantation (OLT-Whipple) to achieve complete eradication of early-stage CC complicating primary sclerosing cholangitis (PSC).
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adolescent. Adult. Disease-Free Survival. Early Diagnosis. Female. Follow-Up Studies. Hepatectomy. Humans. Liver Transplantation. Male. Mass Screening. Middle Aged. Pancreaticoduodenectomy. Retrospective Studies

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  • (PMID = 20021907.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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80. Nuzzo G, Clemente G, Giovannini I, De Rose AM, Vellone M, Sarno G, Marchi D, Giuliante F: Liver resection for primary intrahepatic stones: a single-center experience. Arch Surg; 2008 Jun;143(6):570-3; discussion 574
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  • [Title] Liver resection for primary intrahepatic stones: a single-center experience.
  • HYPOTHESIS: Primary intrahepatic lithiasis occurs frequently in East Asia but is rare in Western countries.
  • Biliary pain and episodes of cholangitis are the most common presenting symptoms, whereas intrahepatic cholangiocarcinoma represents a long-term unfavorable complication of the disease.
  • PATIENTS: The clinical records of 35 patients treated for primary intrahepatic lithiasis between January 1, 1992, and December 31, 2005, were reviewed and clinical data, cholangiograms, operative procedures, and early and late results were examined.
  • A cholangiocarcinoma was found in 3 patients (8.6%): 2 underwent liver resection and 1, who was found unresectable at surgery, underwent only explorative laparotomy.
  • CONCLUSIONS: Primary intrahepatic lithiasis more commonly involves 1 single liver segment or lobe.
  • [MeSH-minor] Adult. Aged. Cholangiography. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Time Factors

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  • (PMID = 18559750.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Singh P, Erickson RA, Mukhopadhyay P, Gopal S, Kiss A, Khan A, Ulf Westblom T: EUS for detection of the hepatocellular carcinoma: results of a prospective study. Gastrointest Endosc; 2007 Aug;66(2):265-73
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  • [Title] EUS for detection of the hepatocellular carcinoma: results of a prospective study.
  • BACKGROUND: Early detection of hepatocellular carcinoma (HCC) and accurate determination of the number of lesions are critical in determining eligibility for liver transplantation or resection.
  • OBJECTIVE: To compare the accuracy of the EUS with CT for the detection of primary tumors of the liver.
  • Nine of these patients had liver tumors (HCC, 8; cholangiocarcinoma, 1).
  • [MeSH-major] Carcinoma, Hepatocellular / ultrasonography. Endosonography. Liver Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Humans. Liver / pathology. Liver / radiography. Liver / ultrasonography. Magnetic Resonance Imaging. Middle Aged. Sensitivity and Specificity. Tomography, X-Ray Computed. Ultrasonography, Interventional

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  • [CommentIn] Gastrointest Endosc. 2007 Aug;66(2):274-6 [17643699.001]
  • (PMID = 17543307.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00290316
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Ben-David MA, Griffith KA, Abu-Isa E, Lawrence TS, Knol J, Zalupski M, Ben-Josef E: External-beam radiotherapy for localized extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys; 2006 Nov 1;66(3):772-9
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  • [Title] External-beam radiotherapy for localized extrahepatic cholangiocarcinoma.
  • PURPOSE: The role of radiation therapy (RT) in extrahepatic cholangiocarcinoma (EHCC) is not clear and only limited reports exist on the use of this modality.
  • [MeSH-major] Bile Duct Neoplasms / radiotherapy. Bile Ducts, Extrahepatic. Cholangiocarcinoma / radiotherapy. Gallbladder Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy / methods. Female. Humans. Male. Middle Aged. Radiotherapy / adverse effects. Radiotherapy Dosage. Survival Analysis


83. Liu XF, Kong FM, Xu Z, Yu SP, Sun FB, Zhang CS, Huang QX, Zhou XT, Song ZW: Promoter hypermethylation of death-associated protein kinase gene in cholangiocarcinoma. Hepatobiliary Pancreat Dis Int; 2007 Aug;6(4):407-11
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  • [Title] Promoter hypermethylation of death-associated protein kinase gene in cholangiocarcinoma.
  • We studied the relationship of methylation status and expression of the DAPK gene with the clinical findings in cholangiocarcinoma.
  • RESULTS: Aberrant methylation of the DAPK gene was detected in 11 (30.6%) of 36 tissue specimens of cholangiocarcinoma, and in 2 (5.6%) of 36 specimens of adjacent normal tissues.
  • CONCLUSIONS: The frequency of DAPK gene methylation in cholangiocarcinoma is high and it may offer an effective means for earlier auxiliary diagnosis of the malignancy.
  • The DAPK gene epigenetically affected by methylation may be associated with the carcinogenesis of cholangiocarcinoma.
  • [MeSH-major] Apoptosis Regulatory Proteins / genetics. Apoptosis Regulatory Proteins / physiology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / genetics. Bile Ducts, Intrahepatic / pathology. Calcium-Calmodulin-Dependent Protein Kinases / genetics. Calcium-Calmodulin-Dependent Protein Kinases / physiology. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / genetics. DNA Methylation. Epigenesis, Genetic. Gene Expression Regulation, Neoplastic. Promoter Regions, Genetic
  • [MeSH-minor] Adult. Aged. Calmodulin / metabolism. Death-Associated Protein Kinases. Female. Humans. Male. Middle Aged. Sulfites / chemistry

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  • (PMID = 17690039.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Calmodulin; 0 / Sulfites; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases; TZX5469Z6I / sodium bisulfite
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84. Woo HG, Lee JH, Yoon JH, Kim CY, Lee HS, Jang JJ, Yi NJ, Suh KS, Lee KU, Park ES, Thorgeirsson SS, Kim YJ: Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma. Cancer Res; 2010 Apr 15;70(8):3034-41
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  • [Title] Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma.
  • Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver cancers.
  • The existence of combined hepatocellular-cholangiocarcinoma (CHC), a histopathologic intermediate form between HCC and CC, suggests phenotypic overlap between these tumors.
  • By performing gene expression profiling of human HCC, CHC, and CC, we identified a novel HCC subtype, i.e., cholangiocarcinoma-like HCC (CLHCC), which expressed cholangiocarcinoma-like traits (CC signature).
  • In conclusion, we suggest that the acquisition of cholangiocarcinoma-like expression traits plays a critical role in the heterogeneous progression of HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Cholangiocarcinoma / metabolism. Gene Expression Regulation, Neoplastic. Liver Neoplasms / metabolism

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  • [Copyright] (c)2010 AACR.
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  • (PMID = 20395200.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE15765
  • [Grant] United States / Intramural NIH HHS / / ZIA BC011173-01
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS182474; NLM/ PMC3498758
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85. Burger I, Hong K, Schulick R, Georgiades C, Thuluvath P, Choti M, Kamel I, Geschwind JF: Transcatheter arterial chemoembolization in unresectable cholangiocarcinoma: initial experience in a single institution. J Vasc Interv Radiol; 2005 Mar;16(3):353-61
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  • [Title] Transcatheter arterial chemoembolization in unresectable cholangiocarcinoma: initial experience in a single institution.
  • PURPOSE: Unresectable cholangiocarcinoma carries a dismal prognosis, with median survival times ranging from 6 to 12 months from the time of diagnosis.
  • Conversely, transcatheter arterial chemoembolization (TACE) has been effective in prolonging the lives of patients with hepatocellular carcinoma but has not been used against cholangiocarcinoma.
  • Therefore, the purpose of the present study was to assess the safety and efficacy (ie, survival) of TACE in patients with unresectable intrahepatic cholangiocarcinoma.
  • MATERIALS AND METHODS: Seventeen patients with unresectable cholangiocarcinoma were treated with one or more cycles of TACE between 1995 and 2004 at our institution.
  • CONCLUSIONS: The results suggest that TACE was effective at prolonging survival of patients with unresectable cholangiocarcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Chemoembolization, Therapeutic. Cholangiocarcinoma / therapy
  • [MeSH-minor] Adult. Aged. Contrast Media. Female. Gadolinium DTPA. Humans. Iodized Oil / administration & dosage. Magnetic Resonance Imaging. Male. Middle Aged. Palliative Care. Prospective Studies. Radiography, Interventional. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15758131.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 8001-40-9 / Iodized Oil; K2I13DR72L / Gadolinium DTPA
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86. Hu ZM, Wu WD, Zhang CW, Zhang YH, Ye ZY, Zhao DJ: [Selective exclusion of hepatic outflow and inflow in hepatectomy for huge hepatic tumor]. Zhonghua Zhong Liu Za Zhi; 2008 Aug;30(8):620-2
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  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatectomy / methods. Hepatic Veins / surgery. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Alanine Transaminase / blood. Bile Duct Neoplasms / blood. Bile Duct Neoplasms / blood supply. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Blood Loss, Surgical. Cholangiocarcinoma / blood. Cholangiocarcinoma / blood supply. Cholangiocarcinoma / surgery. Female. Humans. Intraoperative Care. Liver / blood supply. Liver / surgery. Male. Middle Aged. Prealbumin / metabolism. Young Adult

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  • (PMID = 19102943.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Prealbumin; EC 2.6.1.2 / Alanine Transaminase
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87. Khalbuss WE, Grigorian S, Bui MM, Elhosseiny A: Small-cell tumors of the liver: a cytological study of 91 cases and a review of the literature. Diagn Cytopathol; 2005 Jul;33(1):8-14
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  • The diagnostic categories included 44 cases of metastatic small-cell undifferentiated carcinoma, 15 cases of metastatic neuroendocrine carcinoma, 10 cases of metastatic adenocarcinoma, 7 cases of malignant lymphoma, 4 cases of hepatocellular carcinoma with small-cell features, 2 cases of cholangiocarcinoma, 1 case of poorly differentiated carcinoma, and 8 cases of rare tumors including granulosa cell tumor (2 cases), sarcoma (4 cases), malignant melanoma with small-cell features (1 case), and meningioma with small-cell features (1 case).
  • [MeSH-major] Carcinoma, Small Cell / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Carcinoma, Neuroendocrine / metabolism. Carcinoma, Neuroendocrine / pathology. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Liver / chemistry. Liver / pathology. Lymphoma / metabolism. Lymphoma / pathology. Male. Middle Aged. Mucin-1 / analysis. Review Literature as Topic. S100 Proteins / analysis. Vimentin / analysis

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  • [Copyright] 2005 Wiley-Liss, Inc
  • (PMID = 15945087.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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88. He F, Yan Q, Fan L, Liu Y, Cui J, Wang J, Wang L, Wang Y, Wang Z, Guo Y, Huang G: PBK/TOPK in the differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma and its involvement in prognosis of human cholangiocarcinoma. Hum Pathol; 2010 Mar;41(3):415-24
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  • [Title] PBK/TOPK in the differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma and its involvement in prognosis of human cholangiocarcinoma.
  • In this study, we analyzed PBK/TOPK expression in hepatic primary tumor and explored its role in cholangiocarcinoma biology.
  • The protein, mRNA of PBK/TOPK, and cell cycle of cholangiocarcinoma cell line after PBK/TOPK suppression with small interfere RNA were studied by Western blot, semiquantitative reverse transcriptase-polymerase chain reaction, and flow cytometry, respectively.
  • PBK/TOPK was usually expressed in normal bile duct epithelial cells and much more frequently expressed in cholangiocarcinoma (68/74) but never expressed in hepatocytes and hepatocellular carcinomas (0/33).
  • PBK/TOPK down-regulation was related to the poor prognosis of patients with cholangiocarcinoma (P = .013).
  • Epidermal growth factor can enhance PBK/TOPK expression in cholangiocarcinoma QBC 939 cells, but suppression of PBK/TOPK in the cells did not affect their proliferation.
  • PBK/TOPK protein could serve as a useful indicator for histopathologic differentiation between cholangiocarcinoma and hepatocellular carcinomas and the low expression of PBK/TOPK is predicative of poor survival in cholangiocarcinoma patients.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Cholangiocarcinoma / diagnosis. Liver Neoplasms / diagnosis. Protein-Serine-Threonine Kinases / metabolism
  • [MeSH-minor] Adult. Aged. Bile Ducts / metabolism. Blotting, Western. Cell Cycle / physiology. Cell Line, Tumor. Cells, Cultured. Diagnosis, Differential. Epithelial Cells / metabolism. Female. Flow Cytometry. Gene Silencing. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Mitogen-Activated Protein Kinase Kinases. Prognosis. Proportional Hazards Models. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sex Factors

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19954816.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 2.7.12.2 / PDZ-binding kinase
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89. Sasaki M, Yamaguchi J, Ikeda H, Itatsu K, Nakanuma Y: Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies. Hum Pathol; 2009 Dec;40(12):1723-30
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  • [Title] Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies.
  • We examined the significance of the Bmi1 expression in intrahepatic cholangiocarcinoma.
  • The expression of Bmi1 was examined in intrahepatic cholangiocarcinoma (n = 30; 9 bile ductular carcinoma, 8 intrahepatic cholangiocarcinoma of peripheral type, and 13 of hilar type) by using immunohistochemistry and real-time polymerase chain reaction.
  • The expression level of Bmi1 was assessed in 7 cholangiocarcinoma cell lines.
  • The effect of Bmi1 knockdown was examined in cultured cholangiocarcinoma cells (HuCCT1 and TFK-1) using small interfering RNA.
  • Bmi1 was consistently expressed in nonneoplastic biliary epithelial cells and in all intrahepatic cholangiocarcinoma, irrespective of the location and histological degree of differentiation.
  • The level of mRNA expression was significantly higher in 13 (81.3%) of 16 intrahepatic cholangiocarcinoma compared with the corresponding nonneoplastic tissues.
  • All 7 cultured cholangiocarcinoma cells overexpressed Bmi1 to various degrees.
  • The overexpression of polycomb-group protein Bmi1 is essential for colony formation and cell proliferation, probably by the repression of cellular senescence in intrahepatic cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / metabolism. Cell Aging / physiology. Cholangiocarcinoma / metabolism. Nuclear Proteins / biosynthesis. Proto-Oncogene Proteins / biosynthesis. Repressor Proteins / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blotting, Western. Cell Proliferation. Female. Fluorescent Antibody Technique. Humans. Immunohistochemistry. In Vitro Techniques. Male. Middle Aged. Polycomb Repressive Complex 1. RNA, Messenger / analysis. RNA, Small Interfering. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation

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  • (PMID = 19695678.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BMI1 protein, human; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Repressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
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90. Bergquist A, Said K, Broomé U: Changes over a 20-year period in the clinical presentation of primary sclerosing cholangitis in Sweden. Scand J Gastroenterol; 2007 Jan;42(1):88-93
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  • [Title] Changes over a 20-year period in the clinical presentation of primary sclerosing cholangitis in Sweden.
  • OBJECTIVE: The use of magnetic resonance cholangiopancreaticography (MRCP) as a non-invasive diagnostic tool for primary sclerosing cholangitis (PSC), together with increased clinical awareness of the disease, has led to earlier diagnosis.
  • The aim of this study was to investigate the clinical presentation of PSC including its association with inflammatory bowel disease (IBD) and the development of cholangiocarcinoma at one centre over an observation period of 20 years.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Female. Humans. Inflammatory Bowel Diseases / complications. Male. Sweden

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  • (PMID = 17190768.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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91. Chok KS, Ng KK, Cheung TT, Yuen WK, Poon RT, Lo CM, Fan ST: An update on long-term outcome of curative hepatic resection for hepatocholangiocarcinoma. World J Surg; 2009 Sep;33(9):1916-21
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  • BACKGROUND: Hepatocholangiocarcinoma (HCC-CC) is a rare primary liver cancer.
  • PATIENTS AND METHODS: Prospectively collected data from December 1991 to 2006 recording patients with primary liver cancer receiving curative hepatectomy were reviewed.
  • Their long-term outcome of resection was analyzed and compared to that of patients with cholangiocarcinoma (CC) or hepatocellular carcinoma (HCC).
  • All HCC-CC patients died within 120 months of primary surgery.
  • [MeSH-major] Cholangiocarcinoma / surgery. Hepatectomy / methods. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Prospective Studies. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • (PMID = 19548027.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Cheng Y, Chen Y, Chen H: Application of portal parenchyma-enterostomy after high hilar resection for Bismuth type IV hilar cholangiocarcinoma. Am Surg; 2010 Feb;76(2):182-7
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  • [Title] Application of portal parenchyma-enterostomy after high hilar resection for Bismuth type IV hilar cholangiocarcinoma.
  • For the surgical treatment of Bismuth Type IV hilar cholangiocarcinoma, it is difficult to achieve curative resection (R0 resection) with restrictive excision (local resection and parenchyma-preserving liver resection) as a result of the complexity and difficulty in biliary reconstruction.
  • Eleven patients with Bismuth IV hilar cholangiocarcinoma underwent high hilar resection (resection for tumors in bile ducts and 1 cm above the tumors including segments IVb, V, and part of the caudate liver lobe) and the biliary tract was reconstructed through a portal parenchyma-enterostomy.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery. Hepatectomy / methods. Jejunostomy / methods. Portal Vein / surgery
  • [MeSH-minor] Adult. Aged. Anastomosis, Surgical / methods. Cholangiopancreatography, Magnetic Resonance. Female. Follow-Up Studies. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Retrospective Studies. Suture Techniques. Treatment Outcome

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  • (PMID = 20336897.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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93. Dong AS, Tian JM, Lu JP, Zuo CJ, Wang L, Wang J: [In vivo proton magnetic resonance spectroscopy of hepatocellular carcinoma and cholangiocarcinoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2009 Apr;31(2):151-4
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  • [Title] [In vivo proton magnetic resonance spectroscopy of hepatocellular carcinoma and cholangiocarcinoma].
  • OBJECTIVE: To investigate the value of in vivo proton magnetic resonance spectroscopy (1H MRS) in the assessment of hepatocellular carcinoma (HCC) and cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / diagnosis. Cholangiocarcinoma / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Spectroscopy / methods
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Protons. Retrospective Studies

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  • (PMID = 19507591.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Protons
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94. He Y, Li ZH, Cai JX, Han BL, He ZP, Wang SG, Bie P: [Surgical treatment for hilar cholangiocarcinoma of Bismuth-Corlette type IV]. Zhonghua Wai Ke Za Zhi; 2009 Aug 1;47(15):1151-4
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  • [Title] [Surgical treatment for hilar cholangiocarcinoma of Bismuth-Corlette type IV].
  • OBJECTIVE: To investigate the surgical treatment for hilar cholangiocarcinoma(HCCA) of Bismuth-Corlette type IV.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Drainage. Female. Follow-Up Studies. Hepatectomy. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 20021906.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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95. Sornmayura P, Boonsakan P, Sobhonslidsuk A, Sriphojanart S, Euanorasetr C, Bunyaratvej S: Dysplastic nodules and small primary carcinoma of the liver: a study detecting the early morphological changes during hepatocarcinogenesis. J Med Assoc Thai; 2007 Feb;90(2):352-62
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  • [Title] Dysplastic nodules and small primary carcinoma of the liver: a study detecting the early morphological changes during hepatocarcinogenesis.
  • MATERIAL AND METHOD: Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining.
  • RESULTS: One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma.
  • CONCLUSION: The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma.
  • [MeSH-minor] Adult. Early Diagnosis. Female. Humans. Male. Middle Aged. Retrospective Studies. Time Factors

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  • (PMID = 17375643.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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96. Giuliante F, Ardito F, Vellone M, Nuzzo G: Liver resections for hilar cholangiocarcinoma. Eur Rev Med Pharmacol Sci; 2010 Apr;14(4):368-70
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  • [Title] Liver resections for hilar cholangiocarcinoma.
  • Hilar cholangiocarcinoma (HC) is a rare tumor which has to be distinguished by intrahepatic cholagiocarcinoma invading hepatic hilum because the former has better prognosis then the latter.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Cholangiocarcinoma / surgery. Liver / surgery. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Survival Rate. Treatment Outcome

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  • (PMID = 20496550.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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97. Wang WB, Li YH, Liu B, Wang HS, Cui AR, Zhnag XH: [Correlation between PPARgamma and VEGF-C expression in extrahepatic cholangioadenocarcinoma (EHCAC) and their prognostic significance]. Zhonghua Zhong Liu Za Zhi; 2009 Oct;31(10):773-7
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  • [MeSH-major] Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic. Cholangiocarcinoma / metabolism. PPAR gamma / metabolism. Vascular Endothelial Growth Factor C / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Proportional Hazards Models. Survival Rate

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  • (PMID = 20021832.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / PPAR gamma; 0 / VEGFC protein, human; 0 / Vascular Endothelial Growth Factor C
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98. Tang D, Nagano H, Nakamura M, Wada H, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K, Monden M: Clinical and pathological features of Allen's type C classification of resected combined hepatocellular and cholangiocarcinoma: a comparative study with hepatocellular carcinoma and cholangiocellular carcinoma. J Gastrointest Surg; 2006 Jul-Aug;10(7):987-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and pathological features of Allen's type C classification of resected combined hepatocellular and cholangiocarcinoma: a comparative study with hepatocellular carcinoma and cholangiocellular carcinoma.
  • The clinical features of Allen's type C of combined hepatocellular and cholangiocarcinoma (cHCC-CC) are not well known.
  • In this study, we aim to define the clinicopathologic features of cHCC-CC and to evaluate the preoperative diagnosis and surgical treatment results in comparison with those of hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC).
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / pathology. Cholangiocarcinoma / surgery. Liver Neoplasms / pathology. Liver Neoplasms / surgery. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery
  • [MeSH-minor] Adult. Aged. Female. Hepatectomy. Humans. Immunohistochemistry. Male. Middle Aged. Retrospective Studies. Survival Rate

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  • (PMID = 16843869.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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99. Geng XP, Zhu HG, Liu FB, Hou H, Zhang ZG, Zhao HC, Wang GB, Zhao YJ: [Anatomy problems in the radical resection for hilar cholangiocarcinoma]. Zhonghua Wai Ke Za Zhi; 2009 Aug 1;47(15):1167-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anatomy problems in the radical resection for hilar cholangiocarcinoma].
  • OBJECTIVE: To analyze the clinical data, surgical strategies and results from the patients with hilar cholangiocarcinoma (HCCA), and to explore the anatomic factors related to the radical resection.
  • CONCLUSIONS: Some anatomical factors should be considered during the radical resection of hilar cholangiocarcinoma, especially evaluation of potential hepatectomy, resection of caudate lobe, hepatic artery resection and/or reconstruction.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hepatectomy. Humans. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 20021909.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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100. Tufail M, Rizwan MM, Majid HJ: Pleomorphic rhabdomyosarcoma within a choledochal cyst; a rare cause of obstructive jaundice. J Pak Med Assoc; 2006 Aug;56(8):379-81
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  • Histopathologically it is Cholangiocarcinoma in the majority of cases with poor long-term prognosis.
  • However, Rhabdomyosarcoma associated with choledochal cyst in an adult is rarely reported before.
  • The authors report one such case in an adult female patient who presented to us with features of obstructive jaundice.

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  • (PMID = 16967793.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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