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1. Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M: Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol; 2006 Jun-Jul;27(6):1362-9
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  • [Title] Apparent diffusion coefficients for differentiation of cerebellar tumors in children.
  • We hypothesized that cerebellar tumors in children can be differentiated by their ADC values.
  • METHODS: Brain MR imaging studies that included ADC maps were retrospectively reviewed in 32 patients with histologically proved cerebellar neoplasm.
  • There were 17 juvenile pilocytic astrocytomas (JPA), 8 medulloblastomas, 5 ependymomas, and 2 rhabdoid (atypical teratoid/rhabdoid tumor [AT/RT]) tumors.
  • Absolute ADC values of contrast-enhancing solid tumor regions and ADC ratios (ADC of solid tumor to ADC of normal-appearing white matter) were compared with the histologic diagnosis.
  • ADC ratios were also significantly different among these 3 tumor types.
  • CONCLUSION: Assessment of ADC values of enhancing solid tumor is a simple and reliable technique for preoperative differentiation of cerebellar tumors in pediatric patients.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Astrocytoma / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / diagnosis. Ependymoma / pathology. Female. Humans. Infant. Male. Medulloblastoma / diagnosis. Medulloblastoma / pathology

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  • [CommentIn] Nat Clin Pract Neurol. 2007 Feb;3(2):78-9 [17279080.001]
  • (PMID = 16775298.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Adachi M, Kawanami T, Ohshima H, Hosoya T: Cerebellar atrophy attributed to cerebellitis in two patients. Magn Reson Med Sci; 2005;4(2):103-7
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  • [Title] Cerebellar atrophy attributed to cerebellitis in two patients.
  • In a review of magnetic resonance (MR) images from patients with spinocerebellar degeneration (SCD), we found 2 rare patients considered to be in late-stage cerebellitis who showed isolated cerebellar atrophy.
  • The patients were negative for the spinocerebellar ataxia (SCA) genes and had no symptoms of hypothyroidism, history of malignant tumors, or history of alcohol and drug (phenytoin) abuse, which may cause cerebellar atrophy.
  • MR images demonstrated generalized atrophy of the cerebellum, excluding the brainstem or cerebrum.
  • In these cases, moreover, slightly high intensities were noted in the affected cerebellar cortices on fluid-attenuated inversion recovery (FLAIR) images.
  • [MeSH-major] Cerebellar Diseases / complications. Cerebellar Diseases / diagnosis. Magnetic Resonance Imaging / methods. Spinocerebellar Ataxias / etiology. Spinocerebellar Degenerations / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Fever / complications. Humans. Male

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  • (PMID = 16340165.001).
  • [ISSN] 1347-3182
  • [Journal-full-title] Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
  • [ISO-abbreviation] Magn Reson Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Bedre G, Gupta T, Rajasekharan P, Munshi A, Jalali R: Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns? JOP; 2007;8(4):444-9
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  • [Title] Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns?
  • Cerebellar and pancreatic metastases from tumors of mesenchymal origin such as soft tissue sarcomas are exceptional, more so in the absence of pulmonary metastases.
  • An MRI brain scan was suggestive of a solitary cerebellar metastasis.
  • CONCLUSION: Cerebellar, pancreatic, and paraspinal metastases from soft tissue sarcomas are rare, especially in the absence of pulmonary metastases.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Pancreatic Neoplasms / secondary. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17625297.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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4. Afshar-Oromieh A, Linhart H, Podlesek D, Schrempf W, Schackert G, Krex D: Postoperative cerebellar mutism in adult patients with Lhermitte-Duclos disease. Neurosurg Rev; 2010 Oct;33(4):401-8
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  • [Title] Postoperative cerebellar mutism in adult patients with Lhermitte-Duclos disease.
  • Cerebellar mutism (CM) is a rare and severe form of speech and language impairment, mostly diagnosed in children and adolescents and rarely reported in adults.
  • We also report two illustrative cases of CM following surgical treatment of Lhermitte-Duclos disease (LDD; dysplastic gangliocytoma) in two adult patients.
  • LDD is a rare benign cerebellar tumor.
  • However, surgery is hampered by the difficulty to distinguish between tumor and healthy cerebellar tissue, which may result in extensive resection and cause neurological deficits such as CM.
  • Despite the severity, CM carries a favorable prognosis and generally resolves within a few months.To conclude, we review the clinical signs and particularly the pathophysiological observations and anatomical structures affected in the development of postoperative CM and contribute two cases illustrating the pathogenesis, prognosis, and possible prevention of this syndrome, to focus that CM might also occur in adults even in association with rare tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebellar Diseases / etiology. Cerebellar Diseases / pathology. Cerebellar Diseases / psychology. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellum / pathology. Cerebellum / surgery. Epilepsy, Absence / etiology. Ganglioneuroma / pathology. Ganglioneuroma / surgery. Headache / etiology. Humans. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Prognosis. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20668902.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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5. Rodriguez FJ, Eberhart C, O'Neill BP, Slezak J, Burger PC, Goldthwaite P, Wu W, Giannini C: Histopathologic grading of adult medulloblastomas. Cancer; 2007 Jun 15;109(12):2557-65
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  • [Title] Histopathologic grading of adult medulloblastomas.
  • Whether the same applies to adult medulloblastomas is not known.
  • METHODS: The study included 74 adult patients with histologically confirmed medulloblastomas and retrospectively reassessed 67 cases with available slides for the presence of nodularity, collagen deposition (desmoplasia without nodules), and degree and extent of anaplasia.
  • CONCLUSIONS: The incidence of severe anaplasia in adult medulloblastomas is lower than in the pediatric population.
  • However, the significance of severe anaplasia should be regarded with caution based on the small number of tumors with this feature in the current study.
  • [MeSH-major] Cerebellar Neoplasms / classification. Medulloblastoma / classification
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Female. Humans. Immunoenzyme Techniques. Incidence. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Sex Distribution. Survival Rate

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  • [Copyright] Copyright 2007 American Cancer Society.
  • (PMID = 17487854.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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6. Wells EM, Walsh KS, Khademian ZP, Keating RF, Packer RJ: The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder. Dev Disabil Res Rev; 2008;14(3):221-8
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  • [Title] The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder.
  • The postoperative cerebellar mutism syndrome (CMS), consisting of diminished speech output, hypotonia, ataxia, and emotional lability, occurs after surgery in up to 25% of patients with medulloblastoma and occasionally after removal of other posterior fossa tumors.
  • Theories about the pathophysiology of CMS have evolved along with our understanding of the cerebellum as an important structure in the distributive neurocircuitry underlying complex speech, cognition, and behavior.
  • CMS shares many similarities with the cerebellar cognitive affective syndrome, more commonly described in adults and consisting of disturbances of executive function, visuospatial skills, nonmotor language, and affect regulation.
  • [MeSH-major] Brain Damage, Chronic / etiology. Cerebellar Neoplasms / surgery. Cognition Disorders / etiology. Cranial Fossa, Posterior / surgery. Developmental Disabilities / etiology. Medulloblastoma / surgery. Mood Disorders / etiology. Mutism / etiology. Skull Base Neoplasms / surgery. Survivors / psychology
  • [MeSH-minor] Adolescent. Adult. Child. Child Behavior Disorders / diagnosis. Child Behavior Disorders / etiology. Child Behavior Disorders / psychology. Follow-Up Studies. Humans. Risk Factors. Young Adult

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18924161.001).
  • [ISSN] 1940-5529
  • [Journal-full-title] Developmental disabilities research reviews
  • [ISO-abbreviation] Dev Disabil Res Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 90
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7. Hayashi S, Takeda N, Komura E: Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report. Neurol Med Chir (Tokyo); 2010;50(12):1105-7
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  • [Title] Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report.
  • A 30-year-old woman suffered cerebellar hemorrhage during the delivery of her first child.
  • She had undergone surgical removal of a symptomatic cerebellar hemangioblastoma 6 years previously.
  • Hemangioblastomas are benign tumors that are curable with surgical removal, but can grow during pregnancy.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellum / blood supply. Hemangioblastoma / complications. Intracranial Hemorrhages / etiology. Neoplasm Recurrence, Local / complications
  • [MeSH-minor] Adult. Cerebral Angiography. Female. Humans. Obstetric Labor Complications / etiology. Pregnancy. Pregnancy Complications, Neoplastic / pathology. Pregnancy Complications, Neoplastic / surgery. Treatment Outcome

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  • (PMID = 21206188.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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8. Maryniak A, Roszkowski M: [Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors]. Neurol Neurochir Pol; 2005 May-Jun;39(3):202-6
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  • [Title] [Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors].
  • BACKGROUND AND PURPOSE: The cerebellum has been associated with motor control, but more recent studies have extended its contribution to other functions, such as modulation of emotions, behavioral organization or language.
  • The cerebellar cognitive affective syndrome was described primarily in adults.
  • In children, cerebellar lesions are relatively frequent and some are due to neoplasm.
  • MATERIAL AND METHODS: Cognitive and emotional functions were studied in 66 children who underwent surgery for cerebellar pilocytic astrocytoma at the Department of Neurosurgery of the Children Memorial Health Institute.
  • No significant differences between groups of children with different localization of tumor (vermis or cerebellar hemisphere) were observed.
  • CONCLUSIONS: The present study confirms the psychological deficits following cerebellar lesion in children, similar to the cerebellar cognitive affective syndrome reported in adult patients.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Cognition Disorders / etiology. Mood Disorders / etiology. Neurosurgical Procedures / adverse effects. Speech Disorders / etiology
  • [MeSH-minor] Adaptation, Psychological. Adolescent. Adult. Cerebellum / physiopathology. Cerebellum / surgery. Child. Child, Preschool. Female. Humans. Male. Memory Disorders / etiology. Neuropsychological Tests. Parent-Child Relations. Poland. Retrospective Studies

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  • (PMID = 15981157.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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9. Schoch B, Hogan A, Gizewski ER, Timmann D, Konczak J: Balance control in sitting and standing in children and young adults with benign cerebellar tumors. Cerebellum; 2010 Sep;9(3):324-35
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  • [Title] Balance control in sitting and standing in children and young adults with benign cerebellar tumors.
  • Children and young adolescents with chronic surgical cerebellar lesions show persistent balance control problems during standing when lesions affect the deep cerebellar fastigial and adjacent interposed nuclei.
  • Balance control was assessed in 16 patients after surgery of a benign cerebellar tumor in chronic state and healthy age- and gender-matched control subjects.
  • High-resolution MRI scans were acquired in the cerebellar patients.
  • During sitting, 56% of cerebellar patients exhibited trunkal sway outside the range of healthy controls, and 87.5% of cerebellar patients revealed abnormal sway patterns during standing.
  • In patients with surgery <1-year lesions of the inferior cerebellar vermis also had an impact on balance function.
  • Our results corroborate previous evidence that the extent of permanent damage to the deep cerebellar nuclei greatly impacts on the recovery on balance function.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Neurosurgical Procedures / adverse effects. Postoperative Complications / physiopathology. Postural Balance
  • [MeSH-minor] Adolescent. Adult. Biomechanical Phenomena. Cerebellum / pathology. Cerebellum / physiopathology. Cerebellum / surgery. Child. Female. Humans. Male. Posture. Young Adult

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  • (PMID = 20352395.001).
  • [ISSN] 1473-4230
  • [Journal-full-title] Cerebellum (London, England)
  • [ISO-abbreviation] Cerebellum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Huber JF, Bradley K, Spiegler BJ, Dennis M: Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood. Childs Nerv Syst; 2006 Feb;22(2):132-8
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  • [Title] Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood.
  • BACKGROUND: Following cerebellar tumor resection, some patients develop transient cerebellar mutism (TCM).
  • Although the mutism resolves, it is not known whether there are long-term motor speech deficits in patients with TCM that are in excess of those in individuals with cerebellar tumors who had not developed postoperative TCM.
  • METHODS: Long-term survivors of cerebellar tumors resected in childhood who developed TCM were matched to survivors without TCM and to controls.
  • RESULTS: Tumor survivors who had TCM had significantly more ataxic dysarthric speech and slower speech than either those without TCM or controls and were more dysfluent than controls.
  • Tumor survivors without TCM did not differ from controls on ataxic dysarthria or speech rate.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Medulloblastoma / surgery. Mutism / etiology. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Case-Control Studies. Child. Dysarthria / etiology. Dysarthria / physiopathology. Follow-Up Studies. Humans. Male. Time Factors

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  • (PMID = 16155765.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P01 HD 35946
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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11. Yoshida S, Takahashi H: Cerebellar metastases in patients with cancer. Surg Neurol; 2009 Feb;71(2):184-7; discussion 187

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar metastases in patients with cancer.
  • BACKGROUND: Cerebellar metastases are considered a negative prognostic factor in patients with systemic cancers.
  • We retrospectively reviewed the treatment and outcome of 109 patients with cerebellar metastases.
  • METHODS: A total of 1240 patients with metastatic brain tumors were identified and treated between January 1990 and December 2005.
  • RESULTS: Cerebellar metastases occurred in 109 (8.7%) of these patients.
  • CONCLUSIONS: Aggressive treatment including surgical resection and radiotherapy for patients and high performance status (KPS of at least 70) are associated with longer survival for selected patients with cerebellar metastases.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / secondary. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Radiosurgery. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18295837.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Brandes AA, Franceschi E: Neuro-oncology: Genetic variation in pediatric and adult brain tumors. Nat Rev Neurol; 2010 Dec;6(12):653-4
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  • [Title] Neuro-oncology: Genetic variation in pediatric and adult brain tumors.
  • Two new studies suggest that pediatric medulloblastomas and high-grade gliomas are genetically different from the same tumors in adults.
  • Age-dependent gene expression might affect tumor biology; therefore, therapies for adult medulloblastomas or gliomas might not produce the same clinical outcomes in pediatric patients, and vice versa.
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. Gene Expression Profiling. Glioma / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adult. Child. Genetic Variation. Humans

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  • (PMID = 21131914.001).
  • [ISSN] 1759-4766
  • [Journal-full-title] Nature reviews. Neurology
  • [ISO-abbreviation] Nat Rev Neurol
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] England
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13. Kaylie DM, Warren FM 3rd, Haynes DS, Jackson CG: Neurotologic management of intracranial epidermoid tumors. Laryngoscope; 2005 Jun;115(6):1082-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurotologic management of intracranial epidermoid tumors.
  • OBJECTIVES: Epidermoid cysts are the most common intracranial embryonal tumor, although they account for only 1% of all intracranial tumors.
  • The average tumor size was 3.9 cm; six originated in the cerebellopontine angle and four in the petrous apex.
  • Six patients had a translabyrinthine approach to the tumor, two with additional transcochlear exposure.
  • Two patients had tumors removed by way of the middle fossa approach and one through the suboccipital approach.
  • Multiple cranial nerves were involved by tumor in all patients, including nerves III through XI.
  • The internal carotid artery was involved by tumor in four patients.
  • Eight patients required intradural access for complete tumor removal.
  • Seven had complete tumor removal.
  • [MeSH-minor] Adolescent. Adult. Cerebellar Diseases / surgery. Cerebellopontine Angle. Female. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Retrospective Studies

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  • (PMID = 15933526.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Jagannathan J, Lonser RR, Smith R, DeVroom HL, Oldfield EH: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg; 2008 Feb;108(2):210-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease.
  • OBJECT: Despite the frequency of cerebellar hemangioblastomas in von Hippel-Lindau (VHL) disease, their optimum contemporary management has not been defined, and is made complex because of the multiple, progressive, and protean nature of the tumors found in patients with this disorder.
  • To examine modern management and outcomes of cerebellar hemangioblastomas in VHL disease, the authors reviewed findings in patients with this disease who underwent resection of cerebellar hemangioblastomas.
  • METHODS: Consecutive patients with VHL disease who underwent surgery for cerebellar hemangioblastoma(s) at the National Institutes of Health were included.
  • Eighty consecutive patients (44 female and 36 male patients) underwent 126 operations for removal of 164 cerebellar hemangioblastomas (age at surgery 37.8+/-10.3 years, follow-up duration 96.0+/-60.3 months).
  • Tumors associated with symptoms were larger (diameter 1.8+/-1.9 cm; volume 2.8+/-3.4 cm3; p<0.05) and more likely to be associated with peritumoral edema or peritumoral cysts (100% associated with edema and/or cyst; p<0.05) than asymptomatic tumors (diameter 1.1+/-0.9 cm; volume 0.7+/-0.4 cm3; 18%).
  • More tumors were located in the posterior (74%) compared with the anterior (26%) half of the cerebellum (p<0.05).
  • Preoperative hydrocephalus resolved after tumor removal in 33 cases (94%) and did not require cerebrospinal fluid diversion.
  • CONCLUSIONS: Symptoms and signs caused by cerebellar hemangioblastomas in VHL disease are associated with edema and peritumoral cyst formation/propagation and are treated safely and effectively with resection.
  • Cerebrospinal fluid diversion is rarely necessary after complete tumor removal in patients with preoperative hydrocephalus.
  • Cerebellar hemangioblastomas are preferentially distributed in the posterior half of the cerebellum, as they are in the brainstem and spinal cord.
  • Tumor recurrence is avoided by meticulous extracapsular resection.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Ataxia / physiopathology. Brain Edema / physiopathology. Cerebellar Ataxia / physiopathology. Cranial Irradiation. Cysts / physiopathology. Dissection / methods. Electrocoagulation / methods. Female. Follow-Up Studies. Headache / physiopathology. Humans. Hydrocephalus / physiopathology. Male. Microdissection / methods. Postoperative Complications. Radiosurgery. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 18240914.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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15. Bishop FS, Liu JK, Chin SS, Fults DW: Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report. Neurosurgery; 2008 Jun;62(6):E1378-9; discussion E1379
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  • [Title] Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report.
  • OBJECTIVE: Hemangioblastomas are the most common primary intra-axial tumors of the adult posterior fossa and the tumors most often associated with von Hippel-Lindau disease.
  • Resection of cerebellar hemangioblastomas involves tumor excision and drainage of associated cysts.
  • The cyst wall is considered devoid of tumor cells and is not excised.
  • We present an unusual variant of a hemangioblastoma that showed pathological evidence of a tumor within the cyst wall that correlated with radiographic cyst wall enhancement in a patient with a recurrent hemangioblastoma.
  • CLINICAL PRESENTATION: A 38-year-old woman with von Hippel-Lindau disease presented with a recurrent cerebellar hemangioblastoma despite two previous operations during which the mural nodule was removed but the cyst wall was not.
  • Histopathological examination showed a capillary hemangioblastoma with tumor tissue inside the cyst wall.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Neoplasm Recurrence, Local / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18824960.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Chen Y, Tachibana O, Hasegawa M, Xu R, Hamada J, Yamashita J, Hashimoto N, Takahashi JA: Absence of tight junctions between microvascular endothelial cells in human cerebellar hemangioblastomas. Neurosurgery; 2006 Sep;59(3):660-70; discussion 660-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of tight junctions between microvascular endothelial cells in human cerebellar hemangioblastomas.
  • METHODS: Twenty-four consecutive patients with cerebellar hemangioblastomas were studied.
  • CONCLUSION: The continuity of tight junctions of the BBB is interrupted in human cerebellar hemangioblastomas.
  • Significant absence of astrocytic endfeet and tight junctions can be found in microvessels of hemangioblastomas, which may lead to the breakdown of the BBB in these tumors.
  • [MeSH-major] Blood-Brain Barrier / ultrastructure. Cerebellar Neoplasms / pathology. Endothelial Cells / ultrastructure. Hemangioblastoma / pathology. Tight Junctions / ultrastructure
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16955048.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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17. Patrick TA, Giannini C, Ebersold MJ, Link MJ: Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report. J Neurosurg; 2006 Mar;104(3):452-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report.
  • Metastatic seeding or iatrogenic implantation of numerous types of primary central nervous system tumors, typically along cerebrospinal fluid pathways, is a frequently described albeit rare phenomenon and has never been reported in association with vestibular schwannoma (VS).
  • The authors present a case of inadvertent surgical implantation of VS into the cerebellar hemisphere during resection of a recurrent VS in the cerebellopontine angle and internal auditory canal.
  • Five years later--10 years after initial presentation--follow-up imaging revealed a 1-cm recurrence of the VS and a separate 2.2-cm tumor in the inferior cerebellar parenchyma with surrounding edema.
  • Both tumors were removed without complication by reopening the previous retrosigmoid craniotomy.
  • Histological evaluation of these tumors revealed features typical of VS and similar to those of the tissue obtained from the two prior resections.
  • Given the similarities among these tumors in pathological appearance and mitotic index, the presence of the intraparenchymal cerebellar schwannoma was probably due to intraoperative iatrogenic implantation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Neuroma, Acoustic / etiology
  • [MeSH-minor] Adult. Cerebellopontine Angle / pathology. Humans. Iatrogenic Disease. Male. Mitotic Index. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16572663.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Araujo AP, Ribeiro ME, Ricci R, Torquato RJ, Toma L, Porcionatto MA: Glial cells modulate heparan sulfate proteoglycan (HSPG) expression by neuronal precursors during early postnatal cerebellar development. Int J Dev Neurosci; 2010 Nov;28(7):611-20
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  • [Title] Glial cells modulate heparan sulfate proteoglycan (HSPG) expression by neuronal precursors during early postnatal cerebellar development.
  • Cerebellum controls motor coordination, balance, eye movement, and has been implicated in memory and addiction.
  • As in other parts of the CNS, correct embryonic and postnatal development of the cerebellum is crucial for adequate performance in the adult.
  • Cellular and molecular defects during cerebellar development can lead to severe phenotypes, such as ataxias and tumors.
  • This work aimed to investigate changes in heparan sulfate proteoglycans expression during cerebellar development that could unveil control mechanisms.
  • Using real time RT-PCR we evaluated the expression of syndecans, glypicans and modifying enzymes by isolated cerebellar granule cell precursors, and studied the influence of soluble glial factors on the expression of those genes.
  • Our data show for the first time that cerebellar granule cell precursors express members of the Runx family and that the expression of those genes can also be controlled by glial factors.
  • [MeSH-major] Cerebellum / cytology. Cerebellum / growth & development. Heparan Sulfate Proteoglycans / metabolism. Neural Stem Cells / physiology. Neuroglia / metabolism. Neurons / metabolism

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  • [Copyright] Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20638466.001).
  • [ISSN] 1873-474X
  • [Journal-full-title] International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
  • [ISO-abbreviation] Int. J. Dev. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Core Binding Factor alpha Subunits; 0 / Culture Media, Conditioned; 0 / Heparan Sulfate Proteoglycans
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19. Fukushima S, Terasaki M, Tajima Y, Shigemori M: Granulocytic sarcoma: an unusual complication of acute promyelocytic leukemia causing cerebellar hemorrhage. Case report. J Neurosurg; 2006 Dec;105(6):912-5
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  • [Title] Granulocytic sarcoma: an unusual complication of acute promyelocytic leukemia causing cerebellar hemorrhage. Case report.
  • Granulocytic sarcomas are rare tumors that occur primarily in patients with acute myelogenous leukemia or other myeloproliferative disorders, are seldom seen in patients with acute promyelocytic leukemia (APL), and have never been reported to occur in the cerebellum.
  • The authors describe the case of a patient with APL who harbored a hemorrhagic granulocytic sarcoma in the cerebellum.
  • This 39-year-old woman presented with cerebellar ataxia.
  • Magnetic resonance images revealed an intraaxial tumor in the cerebellum.
  • Results of histopathological studies and immunohistochemical staining of the cerebellar tumor confirmed a granulocytic sarcoma.
  • This is the first report to document a granulocytic sarcoma in the cerebellum as the primary presentation in a patient with APL and abnormal coagulation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Cerebral Hemorrhage / etiology. Leukemia, Promyelocytic, Acute / complications. Sarcoma, Myeloid / etiology
  • [MeSH-minor] Adult. Bone Marrow / pathology. Cerebellar Ataxia / etiology. Cerebellum / pathology. Chimera / genetics. Female. Gene Fusion / genetics. Granulocyte Precursor Cells / pathology. Humans. Inclusion Bodies / pathology. Karyotyping. Magnetic Resonance Imaging. Receptors, Retinoic Acid / genetics

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  • (PMID = 17405265.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Retinoic Acid; 0 / retinoic acid receptor alpha
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20. Sherman JH, Sheehan JP, Elias WJ, Jane JA Sr: Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases. Surg Neurol; 2005 May;63(5):476-9
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  • [Title] Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases.
  • BACKGROUND: Mutism has been associated with injury to midline cerebellar structures secondary to degenerative disease, tumors, hemorrhage, or surgery.
  • Typically, cerebellar mutism syndrome (CMS) has been seen in children and only rarely described in adults after surgery of the posterior fossa.
  • CASE DESCRIPTION: The authors report on 2 patients each of whom developed cerebellar mutism after tumor resection using a posterior fossa approach.
  • The first patient underwent gross total resection of a pineal region tumor via a supracerebellar approach.
  • The second patient underwent posterior fossa decompression for a left cerebellar hemispheric renal cell carcinoma metastasis with adjacent hemorrhage.
  • One patient displayed a variant of cerebellar mutism with severe ataxic dysarthria without complete absence of speech, whereas the other demonstrated frank mutism.
  • CONCLUSION: It is paramount that neurosurgeons be aware of cerebellar mutism with regard to its very rare occurrence in adults, its time of onset, and typical self-limiting course.
  • [MeSH-major] Brain Neoplasms / surgery. Carcinoma, Renal Cell / surgery. Cerebellum / surgery. Cranial Fossa, Posterior / surgery. Dermoid Cyst / surgery. Mutism / etiology. Neurosurgical Procedures / adverse effects
  • [MeSH-minor] Adult. Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / secondary. Cerebellar Neoplasms / surgery. Decompression, Surgical / adverse effects. Female. Humans. Kidney Neoplasms / pathology. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual. Pinealoma / pathology. Pinealoma / surgery. Postoperative Complications / etiology. Postoperative Complications / pathology. Radiosurgery. Radiotherapy. Treatment Outcome

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  • [CommentIn] Surg Neurol. 2006 Apr;65(4):424 [16531220.001]
  • (PMID = 15883080.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Recio MV, Gallagher MJ, McLean MJ, Abou-Khalil B: Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center. Epilepsy Res; 2007 Aug;76(1):1-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center.
  • PURPOSE: The objective of this study was to describe epilepsy localization, clinical features and surgery outcome in patients with epilepsy and cerebellar structural abnormalities.
  • METHODS: We identified 10 patients with cerebellar lesions and epilepsy from our epilepsy database.
  • Patients with only cerebellar atrophy were excluded.
  • We reviewed imaging data for cerebellar structural findings, as well as cerebral abnormalities.
  • RESULTS: Out of 2288 epilepsy patients in the database, 10 had epilepsy and cerebellar structural abnormalities other than atrophy.
  • The most common cerebellar malformations included Dandy-Walker malformation, cerebellar tumors and posterior fossa arachnoid cyst.
  • CONCLUSION: In this small series, epilepsy associated with cerebellar malformations was usually focal, most often with a temporal lobe focus.
  • The cerebellar lesions did not adversely affect surgical success.
  • [MeSH-major] Cerebellum / abnormalities. Epilepsy / pathology. Epilepsy / surgery. Neurosurgery / methods. Treatment Outcome
  • [MeSH-minor] Adult. Databases, Factual / statistics & numerical data. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Referral and Consultation. Temporal Lobe / surgery

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  • (PMID = 17664061.001).
  • [ISSN] 0920-1211
  • [Journal-full-title] Epilepsy research
  • [ISO-abbreviation] Epilepsy Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
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22. Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG, Majumder S: Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol; 2006 Mar;26(5):1666-78
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  • [Title] Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation.
  • Medulloblastoma, one of the most malignant brain tumors in children, is thought to arise from undifferentiated neural stem/progenitor cells (NSCs) present in the external granule layer of the cerebellum.
  • Previous studies have shown that neither c-Myc nor REST/NRSF alone could cause tumor formation.
  • When injected into intracranial locations in mice, the NSC-M cells did not form tumors either in the cerebellum or in the cerebral cortex.
  • In contrast, the NSC-M-R cells did produce tumors in the cerebellum, the site of human medulloblastoma formation, but not when injected into the cerebral cortex.
  • Furthermore, the NSC-M-R tumors were blocked from terminal neuronal differentiation.
  • To our knowledge, this is the first study in which abnormal expression of a sequence-specific DNA-binding transcriptional repressor has been shown to contribute directly to brain tumor formation.
  • Our findings indicate that abnormal expression of REST/NRSF and Myc in NSCs causes cerebellum-specific tumors by blocking neuronal differentiation and thus maintaining the "stemness" of these cells.

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  • (PMID = 16478988.001).
  • [ISSN] 0270-7306
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NINDS NIH HHS / NS / K08NS43279; United States / NCI NIH HHS / CA / CA16672; United States / NINDS NIH HHS / NS / K08 NS043279; United States / NCI NIH HHS / CA / R01 CA081255; United States / NCI NIH HHS / CA / CA 81255
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RE1-silencing transcription factor; 0 / Recombinant Proteins; 0 / Repressor Proteins; 0 / Transcription Factors; N12000U13O / Doxycycline
  • [Other-IDs] NLM/ PMC1430235
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23. Roth J, Nass D, Ram Z: Cerebellar tumor extension as a late event of long-standing, supratentorial low-grade gliomas: case report. Neurosurgery; 2006 Jun;58(6):E1210; discussion E1210
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  • [Title] Cerebellar tumor extension as a late event of long-standing, supratentorial low-grade gliomas: case report.
  • OBJECTIVE AND IMPORTANCE: Nonpilocytic low-grade glial tumors in adults occur mostly in the supratentorial compartment.
  • The occurrence of LGG in the cerebellum in the setting of a previously existing supratentorial glioma is rare.
  • All three patients presented years after their initial diagnosis with a second, nonenhancing lesion in the cerebellum, compatible with the radiological appearance of LGG.
  • Two patients subsequently became symptomatic from these lesions and underwent surgical resection of the cerebellar lesions that were found to have similar pathological features to the original supratentorial tumors.
  • INTERVENTION: Magnetic resonance imaging did not demonstrate tumor continuity between the supratentorial and infratentorial lesions in any of the patients.
  • The third patient has shown no cerebellar symptoms to date and is only followed with periodic magnetic resonance imaging.
  • CONCLUSION: The anatomic/pathological basis of these rare cases may include a primary, multicentric tumor formation, or a secondary tumor infiltration of the cerebrocerebellar pathways, leading to the formation of the cerebellar tumor.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Glioma / diagnosis. Magnetic Resonance Imaging. Neoplasms, Second Primary / diagnosis. Supratentorial Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged

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  • (PMID = 16723871.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Saito T, Hama S, Kajiwara Y, Sugiyama K, Yamasaki F, Arifin MT, Arita K, Kurisu K: Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas. Anticancer Res; 2006 Mar-Apr;26(2B):1351-7
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  • [Title] Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas.
  • BACKGROUND: Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood.
  • PATIENTS AND METHODS: Clinico-immunohistochemical findings were retrospectively analyzed in 43 supratentorial- and 7 cerebellar GBM.
  • The correlation between survival and immunopositivity for p53, epidermal growth factor receptor (EGFR) and Ki-67 in these tumors was statistically analyzed and compared.
  • All 5 cerebellar GBM patients treated with radio- and chemotherapy were EGFR-immunonegative; they survived significantly longer than patients with supratentorial GBM (p=0.0296) possibly because their EGFR negativity rendered their tumors more highly radiosensitive.
  • CONCLUSION: The better prognosis of patients with cerebellar, EGFR-negative tumors compared to patients with supratentorial tumors is due to the higher radiosensitivity of these tumors.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Glioblastoma / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Supratentorial Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Child. Female. Humans. Immunohistochemistry. Male. Nitrosourea Compounds / administration & dosage. Prognosis. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome

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  • (PMID = 16619544.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Nitrosourea Compounds; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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25. Marques JP, van der Zwaag W, Granziera C, Krueger G, Gruetter R: Cerebellar cortical layers: in vivo visualization with structural high-field-strength MR imaging. Radiology; 2010 Mar;254(3):942-8
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  • [Title] Cerebellar cortical layers: in vivo visualization with structural high-field-strength MR imaging.
  • PURPOSE: To perform in vivo imaging of the cerebellum with an in-plane resolution of 120 mm to observe its cortical granular and molecular layers by taking advantage of the high signal-to-noise ratio and the increased magnetic susceptibility-related contrast available at high magnetic field strength such as 7 T.
  • Gradient-echo images (repetition time msec/echo time msec, 1000/25) of the human cerebellum were acquired with a nominal in-plane resolution of approximately 120 mum and a section thickness of 1 mm.
  • RESULTS: Structures with dimensions as small as 240 mum, such as the granular and molecular layers in the cerebellar cortex, were detected in vivo.
  • The detection of these structures was confirmed by comparing the contrast obtained on T2*-weighted and phase images with that obtained on images of rat cerebellum acquired at 14 T with 30 mum in-plane resolution.
  • CONCLUSION: In vivo cerebellar imaging at near-microscopic resolution is feasible at 7 T.
  • Such detailed observation of an anatomic area that can be affected by a number of neurologic and psychiatric diseases, such as stroke, tumors, autism, and schizophrenia, could potentially provide newer markers for diagnosis and follow-up in patients with such pathologic conditions. (c) RSNA, 2010.
  • [MeSH-major] Cerebellar Cortex / anatomy & histology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adult. Animals. Female. Humans. Image Processing, Computer-Assisted. Male. Rats

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  • [CommentIn] Radiology. 2010 Mar;254(3):647-50 [20177081.001]
  • (PMID = 20177104.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Ela-Dalman N, Arnold AC, Chang LK, Velez FG, Lasky JL 3rd: Abducens nerve ocular neuromyotonia following non-sellar or parasellar tumors. Strabismus; 2007 Jul-Sep;15(3):149-51
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  • [Title] Abducens nerve ocular neuromyotonia following non-sellar or parasellar tumors.
  • We report two unusual cases of abducens nerve ocular neuromyotonia that followed radiation therapy of tumors in areas other than the sellar or parasellar region.
  • [MeSH-major] Abducens Nerve. Cerebellar Neoplasms / radiotherapy. Isaacs Syndrome / etiology. Oculomotor Muscles. Oculomotor Nerve Diseases / etiology. Radiation Injuries / complications. Skull Base Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Diplopia / etiology. Female. Humans. Sella Turcica

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  • (PMID = 17763251.001).
  • [ISSN] 0927-3972
  • [Journal-full-title] Strabismus
  • [ISO-abbreviation] Strabismus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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27. Taraszewska A, Czernicki Z, Andrychowski J: Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults. Folia Neuropathol; 2005;43(3):172-7
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  • [Title] Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults.
  • We report an unusual case of pigmented cerebellar pilocytic astrocytoma presenting with posttraumatic hemorrhage in a 38-year-old man with no history related to the tumor.
  • CT and MRI examination after head injury demonstrated unexpectedly the cystic lesion of 2 cm in diameter in the region of the right cerebellar hemisphere and vermis.
  • In the literature, the examples of neuroepithelial tumors with hemosiderin pigmentation of tumor cells have been rarely documented.

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  • (PMID = 16245213.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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28. Dave KA, Bordey A: GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: implications for proliferation. IUBMB Life; 2009 May;61(5):496-503
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  • [Title] GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: implications for proliferation.
  • GABA, glutamate, and their complement of receptors are essential signaling molecules that regulate developmental processes in both embryonic and young adult mammals.
  • In this review, we describe the current knowledge on the role of GABA and glutamate in development, focusing on the perinatal cerebellum.
  • From our review of the literature and these data, we hypothesize that GABA(A) receptors and metabotropic glutamate receptors may be a novel target for the pharmacological regulation of the cerebellar tumors, medulloblastomas.

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  • (PMID = 19391160.001).
  • [ISSN] 1521-6551
  • [Journal-full-title] IUBMB life
  • [ISO-abbreviation] IUBMB Life
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC007681; United States / NINDS NIH HHS / NS / NS048256; United States / NIDCD NIH HHS / DC / DC007681-02; United States / NIDCD NIH HHS / DC / DC007681; United States / NINDS NIH HHS / NS / NS048256-04; United States / NINDS NIH HHS / NS / R01 NS048256; United States / NINDS NIH HHS / NS / R01 NS048256-04; United States / NIDCD NIH HHS / DC / R01 DC007681-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, GABA-A; 3KX376GY7L / Glutamic Acid; 56-12-2 / gamma-Aminobutyric Acid; SY7Q814VUP / Calcium
  • [Number-of-references] 104
  • [Other-IDs] NLM/ NIHMS100672; NLM/ PMC2675662
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29. Kabacińska A, Dabrowska A, Tarnowska C, Cyryłowski L: [Diagnostic problems of rare cerebellopontine angle tumors]. Otolaryngol Pol; 2007;61(2):184-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic problems of rare cerebellopontine angle tumors].
  • Astrocytoma (neuroepithelial tumor) determine about 25% all the cerebroma but their original location in cerebellopontine angle is seldom.
  • In case of this kind of tumors in this place, the symptoms can be non-characteristic and similar to these, which appear in the acoustic neurinoma.
  • The most important in case of this diagnosis is both that this tumors can infiltrate of the brain tissues and the fact that they can transformate toward the anaplastic astrocytoma or glioblastoma multiforme (very malignant tumors).
  • MATERIAL AND METHODS: [corrected] A rare case of astrocytoma presenting as a cerebellopontine angle tumor is discussed.
  • The special characteristics of this tumor and unusual clinical course are disscused.
  • [MeSH-major] Astrocytoma / radiography. Astrocytoma / surgery. Cerebellar Neoplasms / radiography. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / radiography. Cerebellopontine Angle / surgery. Facial Nerve Diseases / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications. Treatment Outcome

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  • (PMID = 17668807.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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30. Oztürk S, Soyluk O, Görçin S, Alişir S, Güven D, Türkmen A, Sever MS: A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report. J Nephrol; 2005 Nov-Dec;18(6):781-2
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  • [Title] A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report.
  • Hemangioblastoma (HB) is especially prevalent in the cerebellum.
  • On cranial magnetic resonance imaging (MRI), a mass lesion in the right cerebellar hemisphere was observed, 3 x 3 x 3 cm in size, which was pushing against the fourth ventricle, and the right cerebellar peduncle.
  • The pathological diagnosis was cerebellar hemangioblastoma.
  • DISCUSSION: HB causes 2% of all intracranial tumors in the general population.
  • The treatment is surgical excision of the tumor, as in this case.
  • CONCLUSION: When cerebellar symptoms occur or a cerebellar mass lesion is detected in an organ recipient, HB should be considered in the differential diagnosis.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Hemangioblastoma / etiology. Kidney Transplantation / adverse effects
  • [MeSH-minor] Adult. Craniotomy. Follow-Up Studies. Humans. Kidney Failure, Chronic / surgery. Magnetic Resonance Imaging. Male

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  • (PMID = 16358240.001).
  • [ISSN] 1121-8428
  • [Journal-full-title] Journal of nephrology
  • [ISO-abbreviation] J. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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31. Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T: Genetic characterization of adult infratentorial gliomas. J Neurooncol; 2009 Feb;91(3):251-5
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  • [Title] Genetic characterization of adult infratentorial gliomas.
  • Adult infratentorial gliomas are rare and have not been well studied.
  • We therefore conducted genetic analysis of those tumors to see if there was any characteristic that could be relevant in clinical management and understanding of tumorigenesis.
  • Nineteen adult infratentorial gliomas were analyzed for chromosomal aberration by comparative genomic hybridization, and for expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry.
  • The most frequent chromosomal aberration was the gain of 7p, and five of the seven cerebellar or fourth ventricle malignant gliomas had that aberration.
  • However, the gain of 7q, the characteristic abnormality of supratentorial astrocytomas commonly associated with the gaining of 7p, was observed only in 1 of 11 adult infratentorial astrocytic tumors.
  • Our findings might suggest the presence of distinct tumorigenic pathway in adult infratentorial gliomas.
  • [MeSH-major] Brain Neoplasms / genetics. Frontal Lobe / pathology. Glioma / genetics. Receptor, Epidermal Growth Factor / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Chromosome Aberrations. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. Chromosomes, Human, Pair 7 / genetics. Comparative Genomic Hybridization. Female. Humans. Loss of Heterozygosity. Male. Middle Aged. Young Adult

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  • (PMID = 18941867.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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32. Kamide T, Nakada M, Hayashi Y, Suzuki T, Hayashi Y, Uchiyama N, Kijima T, Hamada J: Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report. J Neurooncol; 2010 Nov;100(2):299-303
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  • [Title] Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report.
  • Here, we report the case of a patient with cerebellar high-grade glioma that developed after the patient underwent treatment for medulloblastoma.
  • Magnetic resonance image showed a cerebellar tumor with multiple cavernomas and two lesions that were suspected to be meningiomas.
  • The cerebellar tumor was surgically removed.
  • According to pathological examination, the tumor was a high-grade glioma that was positive for methylated O-6-methylguanine-DNA methyltransferase promoter.
  • In the past, he had received radiotherapy at the age of 5, after which he was operated for desmoplastic medulloblastoma in his right cerebellar hemisphere.
  • To our knowledge, this is the first case of radiation-induced double intracranial tumors accompanied by symptomatic cavernoma.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Glioma / etiology. Hemangioma, Cavernous, Central Nervous System / etiology. Meningioma / etiology. Meningioma / pathology. Neoplasms, Radiation-Induced / pathology
  • [MeSH-minor] Adult. DNA Methylation. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Humans. Male. Medulloblastoma / radiotherapy. Meningeal Neoplasms / etiology. Meningeal Neoplasms / genetics. Meningeal Neoplasms / pathology. Polymerase Chain Reaction. Promoter Regions, Genetic / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20354758.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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33. Phi JH, Park SH, Chung CK, Wang KC, Cho BK, Kim SK: Atypical cell clusters expressing both neuronal and oligodendrocytic markers: novel histological pattern of glioneuronal tumors? Pathol Int; 2009 Oct;59(10):735-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical cell clusters expressing both neuronal and oligodendrocytic markers: novel histological pattern of glioneuronal tumors?
  • Glioneuronal tumors are a group of brain tumors that consist of both neuronal and glial cells.
  • The spectrum of glioneuronal tumors is currently expanding, and many atypical glioneuronal tumors require further characterization.
  • Two patients are described who had an atypical glioneuronal tumor with peculiar pathological features.
  • One patient was a 7-year-old girl with a tumor in the right cerebellar hemisphere.
  • The other was a 37-year-old man with a tumor in the spinal cord.
  • Although the clinical features (age at diagnosis, tumor location, and recurrence) were very different in these patients, the tumors had a characteristic common feature of atypical cell clusters.
  • Intriguingly, the tumor cells in the clusters expressed both neuronal and oligodendroglial markers, indicating aberrant differentiation.
  • Furthermore, the cluster-forming cells had modest proliferative indices and CD133 expression, indicating their role in the growth of the tumor.
  • It is believed that these atypical cell clusters are a novel pattern of differentiation of glioneuronal tumors and that they need further investigation.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cerebellar Neoplasms / pathology. Ganglioglioma / pathology. Neurons / pathology. Oligodendroglia / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Child. Disease-Free Survival. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Treatment Outcome

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  • (PMID = 19788619.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Sasayama T, Nishihara M, Tanaka K, Mizukawa K, Ehara K, Kanomata N, Kohmura E: Two metachronous tumors induced by radiation therapy: case report and review of the literature. J Neurooncol; 2008 Jul;88(3):315-20
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  • [Title] Two metachronous tumors induced by radiation therapy: case report and review of the literature.
  • Various radiation-induced tumors, including meningioma, glioma, and sarcoma, have been reported; however, metachronous intracranial double tumors induced by radiation therapy are extremely rare.
  • A 1-year-old boy had undergone tumor removal and craniospinal radiation therapy (30 Gy) for cerebellar medulloblastoma.
  • Six years later, an infiltrative tumor was newly found in the right fronto-temporal white matter.
  • The patient underwent stereotactic biopsy, and the tumor was found to be an anaplastic astrocytoma.
  • Since both secondary tumors were located within the area of previous radiation and the patient did not have any genetic disease predisposing him to tumors, radiation therapy was considered to be responsible for their tumorigenesis.
  • To our knowledge, this case is the fourth case of radiation-induced double CNS tumors arising after radiotherapy to be described in the literature.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adult. Age of Onset. Cerebellar Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Humans. In Situ Hybridization, Fluorescence. Infant. Loss of Heterozygosity. Magnetic Resonance Imaging. Male. Medulloblastoma / radiotherapy

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  • (PMID = 18373066.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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35. Kagawa N, Maruno M, Suzuki T, Hashiba T, Hashimoto N, Izumoto S, Yoshimine T: Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays. Brain Tumor Pathol; 2006 Apr;23(1):41-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays.
  • Medulloblastoma (MB) is the most frequent infratentorial malignant brain tumor in children.
  • In contrast, primitive neuroectodermal tumor (PNET) is defined as a supratentorial malignant tumor generated from the cerebral hemisphere.
  • These tumors have considerable histological overlap but have different clinical outcomes including overall survival period, recurrence rate, and chemosensitivity.
  • Genes that are frequently amplified in these both these tumors include MSH2, N-myc, AKT3, and EGFR.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Chromosome Aberrations. DNA, Neoplasm / genetics. Medulloblastoma / genetics. Medulloblastoma / pathology. Neuroectodermal Tumors, Primitive / genetics. Neuroectodermal Tumors, Primitive / pathology
  • [MeSH-minor] Biomarkers, Tumor. Cerebellum / pathology. Child. Child, Preschool. Female. Humans. In Situ Hybridization. Infant. Male. Microarray Analysis. Young Adult


36. Inda MM, Castresana JS: RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system. Neuropathology; 2007 Aug;27(4):341-6
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  • [Title] RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system.
  • Although cancer is rare in children, primary brain tumors constitute the most frequent location of solid tumors in childhood.
  • Primitive neuroectodermal tumors (PNET) of the central nervous system can be divided into infratentorial PNET or medulloblastoma (MB), and supratentorial (sPNET) tumors.
  • The RASSF1A (Ras Association Domain Family Protein 1) gene, located at 3p21.3, is highly methylated in multiple primary tumor samples, including neuroblastoma.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Promoter Regions, Genetic. Supratentorial Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. DNA Methylation. Female. Humans. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17899687.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins
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37. Myong NH, Park BJ: Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient. Yonsei Med J; 2009 Aug 31;50(4):576-81
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  • [Title] Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient.
  • The patient was a 25 year-old male with multiple hemangioblastomas at the cerebellum and spinal cord, multiple pancreatic cysts and a renal cell carcinoma; he was diagnosed as having VHL disease.
  • The largest hemangioblastoma at the right cerebellar hemisphere was completely removed, and he received high-dose irradiation postoperatively.
  • The tumor recurred at the same site 7 years later, which was a malignant glioma with no evidence of hemangioblastoma.
  • The malignant glioma showed molecular genetic profiles of radiation-induced tumors because of its diffuse p53 immunostaining and the loss of p16 immunoreactivity.
  • The genetic study to find the loss of heterozygosity (LOH) of VHL gene revealed that only the cerebellar hemangioblastoma showed allelic losses for the gene.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Glioma / diagnosis. Glioma / etiology. Hemangioblastoma / surgery. Radiotherapy / adverse effects. von Hippel-Lindau Disease / radiotherapy
  • [MeSH-minor] Adult. Humans. Male

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  • [Cites] Br J Neurosurg. 1999 Oct;13(5):504-7 [10627785.001]
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  • (PMID = 19718409.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2730623
  • [Keywords] NOTNLM ; Cerebellar neoplasms / hemangioblastoma / malignant glioma / radiation / von Hippel-Lindau disease
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38. Iida M, Tsujimoto S, Nakayama H, Yagishita S: Ultrastructural study of neuronal and related tumors in the ventricles. Brain Tumor Pathol; 2008;25(1):19-23
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  • [Title] Ultrastructural study of neuronal and related tumors in the ventricles.
  • Intraventricular tumors may arise from a variety of cells in the region.
  • There are some difficulties in diagnosing these tumors because of their histologically similar appearance.
  • We analyzed intraventricular tumors, including central neurocytoma, oligodendroglioma, cerebral neuroblastoma, and cerebellar neuroblastoma, the neuronal characters of which were established based on their ultrastructural findings, except for oligodendroglioma.
  • Central neurocytoma and cerebellar neuroblastoma showed synaptic formation, and cerebral neuroblastoma possessed immature neurites.
  • [MeSH-major] Cerebral Ventricle Neoplasms / ultrastructure. Neuroblastoma / ultrastructure. Neurocytoma / ultrastructure. Oligodendroglioma / ultrastructure
  • [MeSH-minor] Adult. Child, Preschool. Female. Humans. Infant. Male. Microscopy, Electron, Transmission

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  • (PMID = 18415662.001).
  • [ISSN] 1433-7398
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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39. Huber JF, Bradley K, Spiegler B, Dennis M: Long-term neuromotor speech deficits in survivors of childhood posterior fossa tumors: effects of tumor type, radiation, age at diagnosis, and survival years. J Child Neurol; 2007 Jul;22(7):848-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term neuromotor speech deficits in survivors of childhood posterior fossa tumors: effects of tumor type, radiation, age at diagnosis, and survival years.
  • The cerebellum is important for the coordination of fluent speech.
  • The authors studied how childhood cerebellar tumors affect long-term neuromotor speech outcomes, including the relation between outcome and tumor type, radiation, age at diagnosis, and survival years.
  • Videotaped speech samples of child and adult long-term survivors of childhood cerebellar astrocytoma (nonradiated) and medulloblastoma (radiated) tumors and healthy controls were analyzed by 2 speech pathologists for ataxic dysarthria, dysfluency, and speech rate.
  • Ataxia varied with tumor type/radiation.
  • Dysfluency varied with a history of a posterior fossa tumor.
  • Speech rate varied with age and tumor type.
  • Adult controls were significantly faster than child controls, although adult tumor survivors were comparable to their child counterparts.
  • Adult controls had significantly faster speech rates than adult survivors of medulloblastoma tumors.
  • Ataxic dysarthric speech characteristics are more frequent in radiated survivors of medulloblastoma tumors than nonradiated survivors of astrocytoma tumors.
  • Dysfluent and slow speech occur in cerebellar tumor survivors, regardless of tumor type and radiation history.
  • Cerebellar tumors in childhood limit speech rate in adulthood.
  • [MeSH-major] Astrocytoma / complications. Cerebellar Neoplasms / complications. Dysarthria / etiology. Infratentorial Neoplasms / complications. Medulloblastoma / complications
  • [MeSH-minor] Adolescent. Adult. Age Factors. Analysis of Variance. Case-Control Studies. Child. Female. Follow-Up Studies. Humans. Male. Mutism / etiology. Radiotherapy / adverse effects. Reference Values. Speech Disorders / classification. Speech Disorders / etiology. Survivors. Treatment Outcome

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  • (PMID = 17715277.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P01 HD 35946
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
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40. Kida Y, Yoshimoto M, Hasegawa T, Fujitani S: [Radiosurgery of epidermoid tumors with gamma knife: possiblility of radiosurgical nerve decompression]. No Shinkei Geka; 2006 Apr;34(4):375-81

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  • [Title] [Radiosurgery of epidermoid tumors with gamma knife: possiblility of radiosurgical nerve decompression].
  • Long-term results of radiosurgery for epidermoid tumors are reported.
  • At radiosurgery whole tumor was covered in 4 cases and partially covered in 3 cases in attempting to relieve cranial nerve signs like trigeminal neuralgia and facial spasm.
  • In the mean follow-up of 52.7 months, all the tumors showed good tumor control without any progression and tumor shrinkage has been confirmed in 2 out of the 7 cases.
  • In conclusion, it is apparent that epidermoid tumors do respond well to radiosurgery and the accompanying hyperactive dysfunction of cranial nerves is significantly improved by gamma knife treatment with either entire or partial tumor coverage.
  • Therefore the radiosurgical nerve decompression for epidermoid tumor seems to be achieved by gamma-radiosurgery.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Cerebellar Neoplasms / surgery. Decompression, Surgical / methods. Radiosurgery / methods
  • [MeSH-minor] Adult. Cerebellopontine Angle. Child. Exfoliatins. Female. Follow-Up Studies. Hemifacial Spasm / etiology. Humans. Male. Middle Aged. Radiotherapy Dosage. Treatment Outcome. Trigeminal Neuralgia / etiology

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  • (PMID = 16613218.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Exfoliatins
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41. Glassmann A, Molly S, Surchev L, Nazwar TA, Holst M, Hartmann W, Baader SL, Oberdick J, Pietsch T, Schilling K: Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells. BMC Dev Biol; 2007;7:111
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  • [Title] Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells.
  • BACKGROUND: Mtss1 encodes an actin-binding protein, dysregulated in a variety of tumors, that interacts with sonic hedgehog/Gli signaling in epidermal cells.
  • Given the prime importance of this pathway for cerebellar development and tumorigenesis, we assessed expression of Mtss1 in the developing murine cerebellum and human medulloblastoma specimens.
  • In the adult CNS, Mtss1 is found exclusively in cerebellar Purkinje cells.
  • Whereas immature granule cells express a Mtss1 variant observed also in peripheral tissues and comprising exon 12, this exon is replaced by a CNS-specific exon, 12a, in more mature granule cells and in adult Purkinje cells.
  • Bioinformatic analysis of Mtss1 suggests that differential exon usage may affect interaction with Fyn and Src, two tyrosine kinases previously recognized as critical for cerebellar cell migration and histogenesis.
  • CONCLUSION: Both the pattern of expression and splicing of Mtss1 is developmentally regulated in the murine cerebellum.
  • These findings are discussed with a view on the potential role of Mtss1 for cytoskeletal dynamics in developing and mature cerebellar neurons.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Cerebellum / growth & development. Gene Expression Regulation, Developmental. Microfilament Proteins / genetics. Neoplasm Proteins / genetics
  • [MeSH-minor] Animals. Cerebellar Neoplasms / pathology. Exons. Humans. Mice. Mice, Inbred C57BL. Mice, Transgenic. Polymerase Chain Reaction. Protein Splicing / genetics. Purkinje Cells / pathology. Tumor Cells, Cultured

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  • (PMID = 17925019.001).
  • [ISSN] 1471-213X
  • [Journal-full-title] BMC developmental biology
  • [ISO-abbreviation] BMC Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Microfilament Proteins; 0 / Mtss1 protein, mouse; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2194783
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42. Han H, Chen G, Zuo H: Microsurgical treatment for 55 patients with hemifacial spasm due to cerebellopontine angle tumors. Neurosurg Rev; 2010 Jul;33(3):335-9; discussion 339-40
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  • [Title] Microsurgical treatment for 55 patients with hemifacial spasm due to cerebellopontine angle tumors.
  • Tumor-related hemifacial spasm (HFS) has been found to be rare.
  • Of these HFS patients, 55 cases were associated with cerebellopontine angle tumors.
  • A small craniectomy was performed in order to excise the tumor.
  • All tumors were found to compress the root exit zone (REZ) of the facial nerve to different extents, but concomitant vascular compression of the facial nerve was observed in a majority of cases, and microvascular decompression of the facial nerve at REZ was conducted in 43 of 55 patients (78.2%) by displacing the co-compressing vasculature away from the REZ and retaining it using a Teflon pad.
  • Intraoperative findings and postoperative pathological examinations suggested that the tumors were epidermoid cysts, meningiomas, and Schwannomas.
  • We concluded from this study that the majority of cases of tumor-related HFS are caused by combined tumor and vascular co-compression at the REZ, and tumor removal and microvascular decompression are required in order to relieve the symptoms.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellopontine Angle. Hemifacial Spasm / etiology. Hemifacial Spasm / surgery. Microsurgery / methods. Neurosurgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Decompression, Surgical / adverse effects. Decompression, Surgical / methods. Female. Follow-Up Studies. Humans. Male. Meningioma / pathology. Meningioma / surgery. Middle Aged. Neoplasm Recurrence, Local. Neurilemmoma / pathology. Neurilemmoma / surgery. Treatment Outcome. Young Adult

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  • (PMID = 20217169.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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43. Shah MN, Leonard JR, Perry A: Rosette-forming glioneuronal tumors of the posterior fossa. J Neurosurg Pediatr; 2010 Jan;5(1):98-103
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  • [Title] Rosette-forming glioneuronal tumors of the posterior fossa.
  • Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare, recently described WHO Grade I neoplasm.
  • The authors report 6 examples of RGNT arising primarily from the cerebellar vermis.
  • The original diagnoses included pilocytic astrocytoma, ependymoma, cerebellar dysembryoplastic neuroepithelial tumor (DNT), and oligodendroglioma.
  • These cases expand the known clinical and histological spectrum of this rare tumor type.
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / surgery. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / surgery. Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Cranial Fossa, Posterior. Ependymoma / diagnosis. Ependymoma / surgery. Magnetic Resonance Imaging. Neuroectodermal Tumors, Primitive / diagnosis. Oligodendroglioma / diagnosis. Oligodendroglioma / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / surgery. Teratoma / diagnosis. Teratoma / surgery
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Female. Humans. Middle Aged

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  • (PMID = 20043744.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Jea A, Coscarella E, Chintagumpala M, Bhattacharjee M, Whitehead WE, Curry DJ, Luerssen TG: Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. J Neurosurg Pediatr; 2010 Feb;5(2):149-54
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  • [Title] Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report.
  • Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type have been published in the adult and pediatric literature.
  • However, the simultaneous occurrence of multiple primary brain tumors with different cell types is rare.
  • Even more rare is the pediatric presentation of multiple primary brain tumors with different cell types.
  • Brain MR imaging demonstrated a heterogeneously enhancing mixed solid/cystic mass of the left cerebellar hemisphere and a larger, midline, more homogeneously enhancing lesion of the superior vermis.
  • Pathological examination revealed the left cerebellar and superior vermian lesions to be a juvenile pilocytic astrocytoma and a medulloblastoma, respectively.
  • To the best of the authors' knowledge, they describe the first known pediatric case in which a medulloblastoma and a juvenile pilocytic astrocytoma presented as synchronous primary brain tumors.
  • They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cerebellar Neoplasms / pathology. Medulloblastoma / pathology


45. Bonner MJ, Hardy KK, Willard VW, Anthony KK, Hood M, Gururangan S: Social functioning and facial expression recognition in survivors of pediatric brain tumors. J Pediatr Psychol; 2008 Nov-Dec;33(10):1142-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Social functioning and facial expression recognition in survivors of pediatric brain tumors.
  • OBJECTIVE: To assess social functioning and facial expression recognition skill in survivors of pediatric brain tumors (BT) as compared to children with juvenile rheumatoid arthritis (JRA).
  • RESULTS: After controlling for estimated IQ, survivors of BT made significantly more errors interpreting adult facial expressions as compared to children with JRA.
  • [MeSH-major] Brain Damage, Chronic / psychology. Brain Neoplasms / psychology. Cognition Disorders / psychology. Emotions. Facial Expression. Pattern Recognition, Visual. Socialization. Survivors / psychology
  • [MeSH-minor] Adolescent. Arthritis, Juvenile / psychology. Astrocytoma / psychology. Cerebellar Neoplasms / psychology. Child. Ependymoma / psychology. Female. Humans. Intelligence. Male. Medulloblastoma / psychology. Personal Construct Theory. Social Behavior Disorders / diagnosis. Social Behavior Disorders / psychology

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  • (PMID = 18390896.001).
  • [ISSN] 1465-735X
  • [Journal-full-title] Journal of pediatric psychology
  • [ISO-abbreviation] J Pediatr Psychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Jalali R, Mallick I, Dutta D, Goswami S, Gupta T, Munshi A, Deshpande D, Sarin R: Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):974-9
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  • [Title] Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy.
  • PURPOSE: To present the effect of radiotherapy doses to different volumes of normal structures on neurocognitive outcomes in young patients with benign and low-grade brain tumors treated prospectively with stereotactic conformal radiotherapy (SCRT).
  • METHODS AND MATERIALS: Twenty-eight patients (median age, 13 years) with residual/progressive brain tumors (10 craniopharyngioma, 8 cerebellar astrocytoma, 6 optic pathway glioma and 4 cerebral low-grade glioma) were treated with SCRT to a dose of 54 Gy in 30 fractions over 6 weeks.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Cognition Disorders / etiology. Glioma / radiotherapy. Intelligence / radiation effects
  • [MeSH-minor] Adolescent. Astrocytoma / radiotherapy. Cerebellar Neoplasms / psychology. Cerebellar Neoplasms / radiotherapy. Child. Cognition / radiation effects. Craniopharyngioma / psychology. Craniopharyngioma / radiotherapy. Female. Humans. Male. Optic Nerve Glioma / radiotherapy. Prospective Studies. Radiotherapy, Conformal / methods. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19864079.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Chang Q, Pang JC, Li KK, Poon WS, Zhou L, Ng HK: Promoter hypermethylation profile of RASSF1A, FHIT, and sFRP1 in intracranial primitive neuroectodermal tumors. Hum Pathol; 2005 Dec;36(12):1265-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Promoter hypermethylation profile of RASSF1A, FHIT, and sFRP1 in intracranial primitive neuroectodermal tumors.
  • Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumors (SPNETs) are histologically alike intracranial PNETs found in different anatomical locations of the brain.
  • The aim of this study was to investigate whether promoter hypermethylation of putative tumor suppressor genes was involved in both types of intracranial PNETs.
  • Our results revealed no promoter hypermethylation of RASSF1A, FHIT, and sFRP1 in 2 normal cerebellar and 5 normal cerebral tissue specimens examined.
  • [MeSH-major] Acid Anhydride Hydrolases / genetics. Brain Neoplasms / genetics. Cell Cycle Proteins / genetics. DNA Methylation. Neoplasm Proteins / genetics. Neuroectodermal Tumors, Primitive / genetics. Protein-Serine-Threonine Kinases / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Ataxia Telangiectasia Mutated Proteins. Cell Line, Tumor. Child. Child, Preschool. DNA Primers / chemistry. DNA, Neoplasm / analysis. Female. Humans. Infant. Male. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16311119.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA Primers; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins; 0 / fragile histidine triad protein; EC 2.7.11.1 / ATR protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 3.6.- / Acid Anhydride Hydrolases
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48. Rasmussen A, Nava-Salazar S, Yescas P, Alonso E, Revuelta R, Ortiz I, Canizales-Quinteros S, Tusié-Luna MT, López-López M: Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma. J Neurosurg; 2006 Mar;104(3):389-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma.
  • OBJECT: Central nervous system (CNS) hemangioblastomas are benign vascular tumors arising either sporadically or as a manifestation of von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome.
  • The authors studied a series of patients with CNS hemangioblastomas and their families to identify germline mutations in the VHL tumor suppressor gene and to establish a predictive testing and screening protocol.
  • All asymptomatic mutation carriers underwent genetic counseling and tumor surveillance.
  • [MeSH-minor] Adolescent. Adult. Cerebellar Neoplasms. Child. Child, Preschool. DNA Mutational Analysis. Female. Genetic Testing. Humans. Male. Mexico. Middle Aged. Pedigree. Prognosis

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  • (PMID = 16572651.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Basu S, Rubello D: PET imaging in the management of tumors of testis and ovary: current thinking and future directions. Minerva Endocrinol; 2008 Sep;33(3):229-56
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  • [Title] PET imaging in the management of tumors of testis and ovary: current thinking and future directions.
  • Of these, the area where FDG-PET imaging has been examined the most in testicular tumors is the evaluation of postchemotherapy residual mass in both seminoma and nonseminomatous germ cell tumors (NSGCT) of the testis, a critical step in determining the subsequent management approach of these tumors that vary amongst various centers.
  • [MeSH-major] Ovarian Neoplasms / radionuclide imaging. Positron-Emission Tomography. Testicular Neoplasms / radionuclide imaging
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Clinical Trials as Topic. Combined Modality Therapy. Cost-Benefit Analysis. Female. Follow-Up Studies. Forecasting. Humans. Lymphoma, Non-Hodgkin / radionuclide imaging. Lymphoma, Non-Hodgkin / therapy. Male. Middle Aged. Neoplasm Staging / methods. Neoplasms, Germ Cell and Embryonal / radionuclide imaging. Neoplasms, Germ Cell and Embryonal / therapy. Paraneoplastic Cerebellar Degeneration / radionuclide imaging. Prognosis. Prospective Studies. Radiopharmaceuticals. Retrospective Studies

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  • (PMID = 18846028.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Number-of-references] 83
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50. Capovilla M, Kambouchner M, Bernier M, Soulier A, Tissier F, Saintigny P: Late cerebellar relapse of a juvenile bronchial carcinoid. Clin Lung Cancer; 2007 Mar;8(5):339-41
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  • [Title] Late cerebellar relapse of a juvenile bronchial carcinoid.
  • Although epithelial bronchial neoplasm is a cancer frequently observed in adult patients, it is rarely observed in patients who are children.
  • The most frequent histologic subtype is well differentiated neuroendocrine tumor, or carcinoid.
  • They have a variable biologic behavior, ranging from benign to malignant tumors capable of very late recurrence or metastasis.
  • We report the case of a child with a pulmonary carcinoid initially considered typical, who presented with relapse in the cerebellum and mediastinum 16 years later.
  • After review of the pathology slides, primary and metastatic tumors were reclassified as atypical carcinoid according to the criteria of the 2004 World Health Organization classification of lung tumors.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / secondary
  • [MeSH-minor] Adolescent. Adult. Humans. Male

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  • (PMID = 17562235.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Nakamura Y, Kanemura Y, Yamada T, Sugita Y, Higaki K, Yamamoto M, Takahashi M, Yamasaki M: D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells. Mod Pathol; 2006 Jul;19(7):974-85
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  • [Title] D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells.
  • It has been used as a marker for lymphatic endothelium as well as mesothelioma and cerebellar hemangioblastoma.
  • In the developing cerebellum, positive D2-40 immunoreactivity was found in the external granular layer particularly of the outer portion and the Purkinje cell layer as well as meninges.
  • Some brain tumors such as anaplastic ependymoma, some medulloblastomas, glioblastoma, pineal germinoma, craniopharyngioma, choroid plexus papilloma, choroid plexus carcinoma, and meningioma showed positive immunoreactivity with D2-40.
  • Therefore, D2-40 antibody is considered a useful marker for research on developing brain and diagnosis of brain tumors, differentiation between choroid plexus carcinoma and metastatic carcinoma.
  • [MeSH-major] Antibodies, Monoclonal. Antigens, Neoplasm / analysis. Brain Neoplasms / immunology. Cerebellum / immunology. Telencephalon / immunology
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Cells, Cultured. Child, Preschool. Fetus / immunology. Gestational Age. Humans. Immunohistochemistry. Infant. Middle Aged. Neurons / cytology. Neurons / immunology. Prosencephalon / cytology. Stem Cells / cytology. Stem Cells / immunology

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  • (PMID = 16648867.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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52. Germanwala AV, Mai JC, Tomycz ND, Niranjan A, Flickinger JC, Kondziolka D, Lunsford LD: Boost Gamma Knife surgery during multimodality management of adult medulloblastoma. J Neurosurg; 2008 Feb;108(2):204-9
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  • [Title] Boost Gamma Knife surgery during multimodality management of adult medulloblastoma.
  • OBJECT: The aim of this paper was to determine prognostic factors for adult medulloblastoma treated with boost Gamma Knife surgery (GKS) following resection and craniospinal irradiation.
  • METHODS: The authors performed a retrospective analysis of 12 adult patients with histologically proven medulloblastoma or supratentorial primitive neuroectodermal tumor who between February 1991 and December 2004 underwent >or=1 sessions of GKS for posttreatment residual or recurrent tumors (6 tumors in each group).
  • Stereotactic radiosurgery was applied to residual and recurrent posterior fossa tumor as well as to foci of intracranial medulloblastoma metastases.
  • The mean GKS-treated tumor volume was 9.4 cm3 (range 0.5-39 cm3).
  • RESULTS: Following adjunctive radiosurgery, 5 patients had no evidence of tumor on magnetic resonance (MR) imaging, 3 patients had stable tumor burden on MR imaging, and 4 patients had evidence of tumor progression locally with or without intracranial metastases.
  • All patients with tumor progression died.
  • The majority of patients who achieved tumor eradication (80%) and tumor stabilization (67%) after GKS had residual tumor as the reason for their referral for GKS.
  • The best outcomes were attained in patients with residual disease who were younger, had smaller tumor volumes, had no evidence of metastatic disease, and had received higher cumulative GKS doses.
  • CONCLUSIONS: Single or multiple GKS sessions were a well-tolerated, feasible, and effective adjunctive treatment for posterior fossa residual or recurrent medulloblastoma as well as intracranial metastatic medulloblastoma in adult patients.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Medulloblastoma / surgery. Neoadjuvant Therapy. Radiosurgery / methods
  • [MeSH-minor] Adult. Age Factors. Chemotherapy, Adjuvant. Cranial Irradiation. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual. Neuroectodermal Tumors / radiotherapy. Neuroectodermal Tumors / surgery. Remission Induction. Retrospective Studies. Spine / radiation effects. Supratentorial Neoplasms / radiotherapy. Supratentorial Neoplasms / surgery. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 18240913.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Chernov MF, Skvortzova TY, Brodskaya ZL: Reduction of blood flow in the brain stem and cerebellum caused by petroclival tumors. Neurol Med Chir (Tokyo); 2005 Jan;45(1):31-5; discussion 36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reduction of blood flow in the brain stem and cerebellum caused by petroclival tumors.
  • Blood flow in the brain stem (BSBF) and cerebellum (CerBF) was investigated by positron emission tomography in 12 patients with petroclival tumors (study group) and 14 healthy volunteers (control group). (15)O-labeled water was used as the radioisotope tracer.
  • Five of 12 patients in the study group exhibited more than 20% reduction of CerBF ipsilateral to the tumor, whereas no such asymmetry was disclosed in any subject in the control group (p < 0.01).
  • Sex, age, and tumor histology had no statistically significant association with the level of BSBF.
  • No statistically significant association between BSBF and the type of postoperative course was found, whereas four of the five patients with more than 20% reduction of CerBF ipsilateral to the tumor had prominently increased cerebellar ataxia after removal of the neoplasm.
  • Preoperative investigation of the cerebral blood flow may be important for the prediction of outcome after surgical resection of petroclival tumors.
  • [MeSH-major] Brain Stem / blood supply. Cerebellum / blood supply. Cerebrovascular Circulation / physiology. Cranial Fossa, Posterior. Skull Base Neoplasms / physiopathology
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15699618.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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54. Sugita Y, Nakamura Y, Yamamoto M, Ogasawara S, Ohshima K, Shigemori M: Expression of KIAA 0864 protein in neuroepithelial tumors: an analysis based on the presence of monoclonal antibody HFB-16. J Neurooncol; 2008 Sep;89(2):151-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of KIAA 0864 protein in neuroepithelial tumors: an analysis based on the presence of monoclonal antibody HFB-16.
  • To elucidate the correlation between the KA protein and neuroepithelial tumors (NETs), the present study assessed the KA expression by the NETs using immunohistochemical and Western blot analyses with HFB-16 monoclonal antibody.
  • Among the 55 NETs, a moderate-to-intense KA protein immunoreactivity was observed in 8 of 8 medulloblastomas, 1 of 1 central nervous system supratentorial primitive neuroectodermal tumor (CNS supratentorial PNET), 4 of 4 retinoblastomas, 1 of 1 neuroblastoma, 8 of 8 central neurocytomas, 4 of 4 oligodendrogliomas, 4 of 4 oligoastrocytomas, 1 of 1 extraventricular neurocytoma, and 1 of 1 gangliocytoma.
  • These results indicate that the antibody HFB-16 could be a useful marker for neuronal tumors and primitive neuroectodermal tumors that may originate from immature neural progenitor cells.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Guanine Nucleotide Exchange Factors / metabolism. Medulloblastoma / metabolism. Neoplasms, Neuroepithelial / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18458818.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Guanine Nucleotide Exchange Factors; 0 / RASGRP3 protein, human
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55. Korshunov A, Remke M, Werft W, Benner A, Ryzhova M, Witt H, Sturm D, Wittmann A, Schöttler A, Felsberg J, Reifenberger G, Rutkowski S, Scheurlen W, Kulozik AE, von Deimling A, Lichter P, Pfister SM: Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification. J Clin Oncol; 2010 Jun 20;28(18):3054-60
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  • [Title] Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.
  • PURPOSE: Medulloblastoma (MB) is the most common malignant brain tumor in children, whereas it rarely presents in adults.
  • We aimed to identify genetic aberrations in 146 adult MBs to evaluate age-dependent differences in tumor biology and adapt age-specific risk stratification models.
  • METHODS: As a screening set, we studied a cohort of 34 adult MBs by using array-based comparative genomic hybridization comparing molecular results with clinical data.
  • DNA copy number aberrations identified as possible prognostic markers were validated in an independent cohort of 112 adult patients with MB by fluorescent in situ hybridization analysis.
  • RESULTS: CDK6 amplification, 10q loss, and 17q gain are the most powerful prognostic markers in adult MB.
  • Whereas MYC/MYCN oncogene amplifications had a high prognostic value in pediatric MB, these aberrations were rarely observed in adult tumors.
  • Surprisingly, adult MBs with 6q deletion and nuclear beta-catenin activation did not share the excellent prognosis with their pediatric counterparts.
  • CONCLUSION: Adult MB is distinct from pediatric MB in terms of genomic aberrations and their impact on clinical outcomes.
  • Therefore, adult MBs require age-specific risk stratification models.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Medulloblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. Proto-Oncogene Proteins c-myc / genetics
  • [MeSH-minor] Adolescent. Adult. Algorithms. Biomarkers, Tumor / genetics. Carcinoma, Large Cell / classification. Carcinoma, Large Cell / genetics. Carcinoma, Large Cell / metabolism. Child. Child, Preschool. Chromosomes, Human, Pair 10 / genetics. Chromosomes, Human, Pair 17 / genetics. Chromosomes, Human, Pair 6 / genetics. Comparative Genomic Hybridization. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Infant. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Prognosis. Risk Assessment. Tissue Array Analysis. Young Adult. beta Catenin / genetics

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  • (PMID = 20479417.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYC protein, human; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin
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56. Marinovic T, Grahovac G, Habek M, Lambasa S, Tomac D: Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient. Clin Neuropathol; 2009 May-Jun;28(3):173-6
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  • [Title] Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient.
  • Multiple primary tumors in the central nervous system of different histological cell types are uncommon.
  • We report a patient who had pilocytic astrocytoma in the cerebellum and ependymoma in the cauda equina region, occurring simultaneously.
  • The suggested mechanism of this association is that primitive multipotent cells might have been displaced in the different CNS areas and developed in different tumor cells.
  • Multiplicity of primary CNS tumors should be considered in certain occasions, when clinical symptoms and signs are pointing in that direction.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Ependymoma / pathology. Neoplasms, Multiple Primary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cauda Equina / pathology. Cauda Equina / surgery. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures

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  • (PMID = 19537133.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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57. Holland H, Koschny R, Krupp W, Meixensberger J, Bauer M, Schober R, Kirsten H, Ganten TM, Ahnert P: Cytogenetic and molecular biological characterization of an adult medulloblastoma. Cancer Genet Cytogenet; 2007 Oct 15;178(2):104-13
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  • [Title] Cytogenetic and molecular biological characterization of an adult medulloblastoma.
  • Medulloblastoma is a malignant invasive embryonal tumor, occurring in children mainly.
  • It is rare in adults (<1% of adult brain tumors), and so comprehensive cytogenetic and molecular biological data on adult medulloblastomas are very limited.
  • We performed comprehensive cytogenetic analyses of an adult medulloblastoma, WHO grade IV, using trypsin-Giemsa staining (GTG-banding), multicolor fluorescence in situ hybridization (M-FISH), and locus-specific FISH, complemented by molecular karyotyping using high-density single nucleotide polymorphism (SNP) arrays.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adult. Child. Chromosome Aberrations. Chromosome Banding. Female. Flow Cytometry. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Matrix Metalloproteinase 2 / genetics. Phosphopyruvate Hydratase / genetics. Polymorphism, Single Nucleotide. Synaptophysin / genetics

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  • (PMID = 17954265.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Synaptophysin; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 4.2.1.11 / Phosphopyruvate Hydratase
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58. Smee RI, Williams JR: Medulloblastomas-primitive neuroectodermal tumours in the adult population. J Med Imaging Radiat Oncol; 2008 Feb;52(1):72-6

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  • [Title] Medulloblastomas-primitive neuroectodermal tumours in the adult population.
  • [MeSH-major] Cerebellar Neoplasms / epidemiology. Medulloblastoma / epidemiology. Neuroectodermal Tumors, Primitive / epidemiology
  • [MeSH-minor] Adolescent. Adult. Databases, Factual / statistics & numerical data. Female. Follow-Up Studies. Humans. Intracranial Pressure. Male. Neoplasm Recurrence, Local. Neurosurgical Procedures. New South Wales / epidemiology. Radiotherapy, Adjuvant. Rare Diseases. Retrospective Studies. Treatment Outcome

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  • (PMID = 18373831.001).
  • [ISSN] 1754-9477
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 29
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59. Tsai MH, Wong AM, Jaing TH, Wang HS, Hsueh C, Wu CT: Treatment of cerebellopontine angle tumors in children: a single institution's experience. J Pediatr Hematol Oncol; 2009 Nov;31(11):832-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of cerebellopontine angle tumors in children: a single institution's experience.
  • The authors discuss the current management for cerebellopontine angle (CPA) tumors in children.
  • CPA tumors accounted for 1% to 3% of intracranial tumors in children.
  • There had been much controversy with the management of these tumors.
  • Eight patients with tumors exclusively confined in the CPA.
  • Sixteen patients with tumors occurred predominantly within CPA and 5 arising from the vicinity and growing mainly into the CPA.
  • Twelve tumors were located in the right CPA (41%) and 5 (17%) on the left.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Infant. Male. Survival Rate

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  • (PMID = 19636269.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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60. Biswas S, Burke A, Cherian S, Williams D, Nicholson J, Horan G, Jefferies S, Williams M, Earl HM, Burnet NG, Hatcher H: Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation? Pediatr Blood Cancer; 2009 Jul;52(7):796-803
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  • [Title] Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?
  • BACKGROUND: Supratentorial PNET (sPNET) are rare CNS tumors of embryonal origin arising in children and adults.
  • METHODS: Medical records were reviewed to gather demographic and clinical data about all embryonal CNS tumors in children and adults from 2001 to 2007.
  • Tumor pathology, clinical management and survival data were also assessed, particularly as regards those patients who received the Packer chemotherapy regimen for either sPNET or MB.
  • RESULTS: Eleven patients (five children and six adults) were identified with non-pineal sPNET, three children with pineal sPNET, and 19 patients (18 children and 1 adult) with MB.
  • There was no difference in overall survival (OS) rates between pediatric and adult sPNET.
  • We suggest that it is time to reconsider the use of this regimen in teenage and young adult non-pineal sPNET and to investigate the utility of alternative approaches.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / therapy. Cranial Irradiation. Medulloblastoma / therapy. Neuroectodermal Tumors, Primitive / therapy. Supratentorial Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Cisplatin / administration & dosage. Follow-Up Studies. Humans. Lomustine / administration & dosage. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome. Vincristine / administration & dosage. Young Adult

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19202566.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine; Q20Q21Q62J / Cisplatin
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61. Terterov S, Krieger MD, Bowen I, McComb JG: Evaluation of intracranial cerebrospinal fluid cytology in staging pediatric medulloblastomas, supratentorial primitive neuroectodermal tumors, and ependymomas. J Neurosurg Pediatr; 2010 Aug;6(2):131-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of intracranial cerebrospinal fluid cytology in staging pediatric medulloblastomas, supratentorial primitive neuroectodermal tumors, and ependymomas.
  • OBJECT: The objective of this study was to determine the role of intracranial CSF examination in detecting true cases of early tumor dissemination.
  • Cerebrospinal fluid dissemination is an ominous feature of pediatric brain tumors, occurring in as many as 30% of medulloblastomas, 25% of supratentorial primitive neuroectodermal tumors (PNETs), and 5% of ependymomas at diagnosis.
  • METHODS: Under an institutional review board-approved protocol, medical records, pathology reports, and radiology reports for 150 patients who had undergone resection of brain tumors (88 with medulloblastomas, 21 with supratentorial PNETs, and 41 with ependymomas) and who had been evaluated using neuraxis MR imaging studies in the last 15 years were retrospectively reviewed.
  • CONCLUSIONS: Discordance exists between the results of neuraxis MR imaging and lumbar and intracranial CSF cytology in perioperative detection of tumor dissemination for pediatric medulloblastoma, supratentorial PNETs, and ependymoma.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebrospinal Fluid / cytology. Ependymoma / pathology. Medulloblastoma / pathology. Neuroectodermal Tumors, Primitive / pathology. Supratentorial Neoplasms / pathology
  • [MeSH-minor] Adolescent. Brain / pathology. Brain / surgery. Cerebellum / pathology. Cerebellum / surgery. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Infant. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Neoplasm Staging. Predictive Value of Tests. Radiotherapy, Adjuvant. Survival Rate. Young Adult

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  • (PMID = 20672933.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Huo L, Bi C, Fang J, Wang Y, Zhang M, Chen F: [Microsurgical treatment and prevention of postoperative complications for the fourth ventricle tumors in adults]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2009 Jul;34(7):642-5
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  • [Title] [Microsurgical treatment and prevention of postoperative complications for the fourth ventricle tumors in adults].
  • OBJECTIVE: To explore the microneurosurgical technique and prevention of postoperative complications for the fourth ventricle tumors in adults.
  • METHODS: We retrospectively analyzed the clinical data of 68 patients with the fourth ventricle tumors between August 2005 and August 2007 in Xiangya Hospital after microsurgical operation.
  • Tumors were excised by inferior vermis cerebellar approach or cerebellomedullary fissure approach.
  • The extent of tumor removal should take into consideration the possible injury of brain stem respiratory center, especially tumors adherent to the brain stem.
  • RESULTS: There were 58 total tumor excisions and 10 subtotal tumor excisions.
  • Hemorrhage in tumor lumen happened in 4 patients, who received second microsurgery.
  • [MeSH-major] Astrocytoma / surgery. Cerebral Ventricle Neoplasms / surgery. Fourth Ventricle / surgery. Microsurgery / methods. Postoperative Complications / prevention & control
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / prevention & control. Male. Middle Aged. Neurosurgical Procedures / methods. Retrospective Studies. Young Adult

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  • (PMID = 19648678.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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63. Phi JH, Kim JH, Eun KM, Wang KC, Park KH, Choi SA, Kim YY, Park SH, Cho BK, Kim SK: Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas. J Neurosurg Pediatr; 2010 Jun;5(6):608-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas.
  • OBJECT: Supratentorial primitive neuroectodermal tumor (PNET) and medulloblastoma are highly malignant embryonal brain tumors.
  • The authors compared the expression of specific genes involved in neuroglial differentiation in supratentorial PNETs and medulloblastomas to define the distinct characters of these tumors.
  • METHODS: The mRNA expression of 8 genes (SOX2, NOTCH1, ID1, ASCL-1, NEUROD1, NEUROG1, NEUROG2, and NRG1) was evaluated in 25 embryonal tumors (12 supratentorial PNETs and 13 medulloblastomas) by quantitative real-time polymerase chain reaction.
  • The expression levels of the transcripts of these genes were compared between the tumor groups.
  • These divergent differentiation patterns may be related to the location and origin of each tumor.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Inhibitor of Differentiation Protein 1 / genetics. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Receptor, Notch1 / genetics. SOXB1 Transcription Factors / genetics. STAT3 Transcription Factor / genetics. Supratentorial Neoplasms / genetics. Up-Regulation / genetics
  • [MeSH-minor] Adolescent. Adult. Cerebellum / pathology. Cerebral Cortex / pathology. Child. Child, Preschool. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. Infant. Infant, Newborn. Male. Neuroglia / pathology. Neurons / pathology. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transcription, Genetic / genetics

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  • (PMID = 20515335.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ID1 protein, human; 0 / Inhibitor of Differentiation Protein 1; 0 / NOTCH1 protein, human; 0 / RNA, Messenger; 0 / Receptor, Notch1; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human
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64. Iwai Y, Yamanaka K: Gamma knife radiosurgery for other primary intra-axial tumors. Prog Neurol Surg; 2009;22:129-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for other primary intra-axial tumors.
  • We report the usefulness of gamma knife radiosurgery for hemangioblastomas, hemangiopericytomas, germ cell tumors and pineal parenchymal tumors, and primary central nervous system lymphoma (PCNSL).
  • In hemangioblastomas, small solid tumors can be treated very effectively.
  • Radiosurgery is a reasonable option to control residual and recurrent germ cell tumors and pineoblastomas.
  • Although the prognosis is poor for PCNSL patients, gamma knife radiosurgery, even with a relatively low tumor margin dose, is an effective treatment for controlling PCNSL.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Hemangiopericytoma / surgery. Neoplasms, Germ Cell and Embryonal / surgery. Pinealoma / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Lymphoma / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis

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  • (PMID = 18948725.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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65. Larysz D, Blamek S, Larysz P, Pietras K, Mandera M: Posterior fossa brain tissue injury: developmental, neuropsychological, and neurological consequences of brain tumors in children. Acta Neurochir Suppl; 2010;106:271-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Posterior fossa brain tissue injury: developmental, neuropsychological, and neurological consequences of brain tumors in children.
  • The aim of the study was the functional neurodevelopmental assessment of children with posterior fossa tumors, specifically examining whether tumor location in particular cerebellar structures determines particular neuropsychological deficits.
  • There were 21 total and 8 subtotal resections of tumor, and marsupialization was performed in cases of arachnoid cysts.
  • Histopathological diagnoses of tumors were as follows: 4 medulloblastomas, 8 pilocytic astrocytomas, 6 fibrillary astrocytomas, 1 anaplastic astrocytoma, 2 oligodendrogliomas, 4 anaplastic ependymomas, 1 choroid plexus papilloma, and 5 arachnoid cysts.
  • Posterior fossa tumors can disturb normal development of higher mental functions, especially in the development of linguistic and emotional traits.
  • Our study aimed to better understand the functional anatomy of the cerebellum in the context of behavioral changes.
  • [MeSH-major] Brain. Brain Injuries / etiology. Cognition Disorders / etiology. Infratentorial Neoplasms. Nervous System Diseases / etiology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Functional Laterality / physiology. Humans. Male. Neuropsychological Tests. Retrospective Studies. Young Adult

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  • (PMID = 19812963.001).
  • [ISSN] 0065-1419
  • [Journal-full-title] Acta neurochirurgica. Supplement
  • [ISO-abbreviation] Acta Neurochir. Suppl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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66. Choi YL, Kim CJ, Matsuo T, Gaetano C, Falconi R, Suh YL, Kim SH, Shin YK, Park SH, Chi JG, Thiele CJ: HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. J Neurooncol; 2005 May;73(1):19-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors.
  • HUlip is highly expressed only in the fetal brain and spinal cord, and is undetected in the adult brain.
  • The purpose of this study was to investigate the pattern of hUlip expression in the developing human brain and nervous system tumors.
  • Ten human brains at different developmental stages and 118 cases of nervous system tumor tissues were examined by immunohistochemistry.
  • Twelve related tumor cell lines were also analyzed by northern blotting and immunoblotting.
  • HUlip was expressed in late fetal and early postnatal brains; strongly in the neurons of the brain stem, basal ganglia/thalamus, and dentate gyrus of the hippocampus, and relatively weakly in the cerebral and cerebellar cortex.
  • Among tumors, hUlip expression was easily detected in tumor cells undergoing neuronal differentiation such as ganglioneuroblastomas and ganglioneuromas.
  • Furthermore, hUlip immunoreactivity was also found in various brain tumors showing neuronal differentiation: central neurocytomas (6 of 6 cases were positive), medulloblastomas (5/11), atypical teratoid rhabdoid tumor (1/1) and gangliogliomas (4/7).
  • Some astrocytic tumors also showed weak positivity: astrocytomas (1 of 5 cases), anaplastic astrocytomas (2/5), and glioblastomas (3/11).
  • The results of this study indicate that the expression of hUlip protein is distinctly restricted to the late fetal and early postnatal periods of human nervous system development and to certain subsets of nervous system tumors.
  • The exact function of hUlip needs to be further clarified; yet the results of our study strongly imply that hUlip function is important in human nervous system development and its aberrant expression in various types of nervous system tumors suggests a role of hUlip as an oncofetal neural antigen.
  • [MeSH-major] Brain / metabolism. Brain Neoplasms / metabolism. Gene Expression Regulation, Developmental / physiology. Gene Expression Regulation, Neoplastic / physiology. Muscle Proteins / metabolism
  • [MeSH-minor] Astrocytes / cytology. Astrocytes / metabolism. Cell Differentiation / genetics. Cell Differentiation / physiology. Cell Line, Tumor. Female. Gestational Age. Humans. Immunohistochemistry. Male. Neuroblastoma / genetics. Neuroblastoma / metabolism. Neurons / cytology. Neurons / metabolism

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  • (PMID = 15933812.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DPYSL3 protein, human; 0 / Muscle Proteins
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67. Narotam PK, Qiao F, Nathoo N: Collagen matrix duraplasty for posterior fossa surgery: evaluation of surgical technique in 52 adult patients. Clinical article. J Neurosurg; 2009 Aug;111(2):380-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collagen matrix duraplasty for posterior fossa surgery: evaluation of surgical technique in 52 adult patients. Clinical article.
  • METHODS: A retrospective analysis was performed in 52 adult patients who had undergone collagen matrix duraplasty for the posterior fossa.
  • RESULTS: The indication for posterior fossa surgery was tumors in 32 patients, vascular abnormalities in 9 patients, and spontaneous cerebellar hemorrhage in 11 patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biocompatible Materials / therapeutic use. Brain Diseases / surgery. Drainage. Female. Humans. Hydrocephalus / complications. Male. Middle Aged. Postoperative Complications. Reconstructive Surgical Procedures / methods. Retrospective Studies

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  • (PMID = 19199453.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 9007-34-5 / Collagen
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68. Lai R: Survival of patients with adult medulloblastoma: a population-based study. Cancer; 2008 Apr 1;112(7):1568-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival of patients with adult medulloblastoma: a population-based study.
  • BACKGROUND: Adult medulloblastoma accounts for less than 1% of adult intracranial tumors.
  • RESULTS: Four hundred fifty-four patients with adult medulloblastoma were diagnosed from 1973-2004 in the 17 regions covered by SEER.
  • [MeSH-major] Cerebellar Neoplasms / mortality. Medulloblastoma / mortality
  • [MeSH-minor] Adult. Cohort Studies. Female. Follow-Up Studies. Humans. Male. Prognosis. Registries. SEER Program. Survival Rate

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  • (PMID = 18278809.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Pascual-Castroviejo I, Pascual-Pascual SI, Viaño J, Carceller F, Gutierrez-Molina M, Morales C, Frutos-Martinez R: Posterior fossa tumors in children with neurofibromatosis type 1 (NF1). Childs Nerv Syst; 2010 Nov;26(11):1599-603
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Posterior fossa tumors in children with neurofibromatosis type 1 (NF1).
  • Four of them had astrocytomas but only in one case was the tumour primarily cerebellar while the tumour was primarily of the brain stem with invasion of the adjacent regions of one or both cerebellar hemispheres in three patients.
  • The patient with primary cerebellar astrocytoma is apparently cured 7 years after the removal of the tumour.
  • The patients with the brain stem tumours extending to the cerebellum, showed a chronic slowly progressive cerebellar disease, but remain alive at age of more than 20 years (one was lost to follow-up).
  • [MeSH-major] Cranial Fossa, Posterior. Neurofibromatosis 1 / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Astrocytoma / mortality. Astrocytoma / pathology. Astrocytoma / surgery. Brain Stem Neoplasms / diagnosis. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / surgery. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy. Male. Medulloblastoma / diagnosis. Medulloblastoma / mortality. Medulloblastoma / pathology. Medulloblastoma / surgery. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Young Adult

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  • [CommentIn] Childs Nerv Syst. 2010 Nov;26(11):1491; author reply 1493 [20853110.001]
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  • (PMID = 20464401.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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70. Durando X, Thivat E, Gilliot O, Irthum B, Verrelle P, Vincent C, Bay JO: Temozolomide treatment of an adult with a relapsing medulloblastoma. Cancer Invest; 2007 Sep;25(6):470-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temozolomide treatment of an adult with a relapsing medulloblastoma.
  • Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors.
  • Here, we report the use of temozolomide in an adult presenting relapsing medulloblastoma.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Cerebellar Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 17882660.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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71. Attard TM, Giglio P, Koppula S, Snyder C, Lynch HT: Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. Cancer; 2007 Feb 15;109(4):761-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis.
  • They are at an increased risk of brain tumors, including cerebellar medulloblastoma, when compared with the general population (Brain Tumor Polyposis-BTP Type 2).
  • Genotype-phenotype correlations between APC gene mutations and central nervous system (CNS) tumors have, thus far not been successful.
  • METHODS: The authors analyzed their established hereditary CRC Registry for brain tumors in FAP pedigrees (56 families, 213 individuals), pooled their patients with BTP and known APC mutations with those reported thus far elsewhere, and compared the resulting mutation distribution of FAP-BTP with the mutation distribution for APC mutations in the US.
  • RESULTS: Twenty-eight patients from 24 families were accrued, the most common brain tumor in BTP was medulloblastoma (60%) predominantly in females (12:5) under the age of 20 (mean age 14.7 SD 9.2).
  • Analysis of the pooled APC mutation data by Chi-square test of association shows an odds ratio of 3.7 (P < .005) for all brain tumor subtypes and 13.1 (P < .001) for medulloblastoma in patients harboring segment 2 APC mutation (codons 679-1224) compared to nonsegment 2 mutation.
  • CONCLUSIONS: In patients with FAP and identifiable APC gene mutation, CNS tumors, especially medulloblastoma which developed in most cases during childhood, are more common in females with FAP and APC gene mutation in codons 686-1217.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli Protein / genetics. Brain Neoplasms / complications. Mutation / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Codon. Female. Humans. Male. Pedigree. Registries


72. Dutta D, Vanere P, Gupta T, Munshi A, Jalali R: Factors influencing activities of daily living using FIM-FAM scoring system before starting adjuvant treatment in patients with brain tumors: results from a prospective study. J Neurooncol; 2009 Aug;94(1):103-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors influencing activities of daily living using FIM-FAM scoring system before starting adjuvant treatment in patients with brain tumors: results from a prospective study.
  • BACKGROUND: Patients with brain tumors have varied degree of functional and psychological impairments because of factors relating to the tumor or to the treatment they receive.
  • MATERIAL AND METHOD: From August 2007 to April 2008, 150 consecutive adult (>18 years) primary brain tumor patients (median age 40 years; male 88, female 62) registered in a general out-patient neuro-oncology clinic were accrued and detailed data were recorded.
  • Seventy percent had malignant tumor (66% high-grade and 34% low-grade; 70% intra-axial).
  • The common sites for tumors included frontal region (30.7%), posterior fossa (12%), and left parietal region (11.3%).
  • Univariate analysis showed total FIM-FAM scores not significantly different with age (< or =35 years vs. >35 years; P = 0.994), sex (male versus female; P = 0.133), and grade of the tumor (high-grade versus low-grade; P = 0.142) but were significantly higher in patients with a Karnofsky performance score (KPS) of > or =70 as compared with <70 (P = 0.001), neurological performance scale (NPS) of 0 or 1 vs. 2 or 3; P = 0.001), disease type (benign versus malignant; P = 0.001), and site of disease (cerebral versus cerebellar; P = 0.024).
  • A trend for correlation between tumor sites with the corresponding function as assesses on the FIM-FAM score was observed.
  • There is strong correlation with age, type of tumor, and site of disease with different functional and cognitive domain impairment.
  • [MeSH-major] Activities of Daily Living / psychology. Brain Neoplasms / psychology. Disability Evaluation. Stress, Psychological / psychology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Analysis of Variance. Female. Humans. Male. Middle Aged. Prospective Studies. Psychometrics. Retrospective Studies. Severity of Illness Index. Young Adult

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  • (PMID = 19255726.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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73. Vieira Santos A, Vilela P, Mateus L, Saraiva PF, Goulão A: [Central nervous system abnormalities namely secondary brain tumors]. Acta Med Port; 2006 Nov-Dec;19(6):451-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Central nervous system abnormalities namely secondary brain tumors].
  • [Transliterated title] Tumor do sistema nervoso central secundário a radioterapia e quimioterapia.
  • Eighteen years later a cerebellar glioblastoma multiforme was diagnosed.
  • The authors speculate about the possibility that this tumor may have been radiation and/or chemotherapy induced.
  • [MeSH-major] Brain Neoplasms / diagnosis. Glioblastoma / diagnosis. Neoplasms, Second Primary / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17583602.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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74. Jouanneau E, Guzman Tovar RA, Desuzinges C, Frappaz D, Louis-Tisserand G, Sunyach MP, Jouvet A, Sindou M: Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report. Neurosurgery; 2006 Apr;58(4):E789; discussion E789
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  • [Title] Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report.
  • OBJECTIVE AND IMPORTANCE: We present a rare case of very long-term medulloblastoma relapse in an adult patient and discuss the pattern of recurrence and metabolic imaging of the tumor.
  • CLINICAL PRESENTATION: A 45-year-old man was referred for evaluation of a frontobasal midline tumor 21 years after treatment of a cerebellar medulloblastoma by surgery followed by chemotherapy and craniospinal radiotherapy.
  • Several hypotheses were discussed, such as other radio-induced tumors, sarcomas, high-grade gliomas, or lymphomas (previous chemotherapy) and even recurrence of medulloblastoma.
  • On diffusion imaging, the tumor appeared hyperintense, with a low apparent diffusion coefficient value of 0.689.
  • The patient underwent complete removal of the tumor that was confirmed to be a metastasis of his primary medulloblastoma.
  • CONCLUSION: Late relapse should be considered, even after several decades, on occurrence of a second intracranial tumor in this context.
  • Our observation validates the clinical interest of preoperative metabolic imaging for brain tumors with distinctive pattern.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 16575298.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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75. Francesco F, Maurizio I, Stefano C, Marina S, Ugo S, Massimo S: Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor. J Neurooncol; 2010 Apr;97(2):285-90
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  • [Title] Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor.
  • Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults.
  • Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors.
  • We describe a pilocytic astrocytoma of the CPA that was found to arise from the proximal portion of trigeminal nerve without any anatomic continuity with the brain stem and the cerebellum.
  • The proposed origin of this extremely rare tumor is the root entry zone of the involved nerve.
  • The tumor was completely resected via a suboccipital retrosigmoid approach.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Cranial Nerve Neoplasms / pathology. Trigeminal Nerve Diseases / pathology
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19820900.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Lagares A, Rivas JJ, Jiménez L, Cicuendez M, Avendaño C: Central demyelination in the pathogenesis of trigeminal neuralgia associated with cerebellopontine angle tumors: case report with ultrastructural trigeminal root analysis. Neurosurgery; 2010 Apr;66(4):E841-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Central demyelination in the pathogenesis of trigeminal neuralgia associated with cerebellopontine angle tumors: case report with ultrastructural trigeminal root analysis.
  • OBJECTIVE: To describe the surgical and ultrastructural findings in the trigeminal root of a patient with trigeminal neuralgia (TN) associated with a cerebellopontine epidermoid tumor, and to relate these to literature reports of patients with vascular compression-related TN.
  • Cranial magnetic resonance imaging revealed an epidermoid tumor in the right cerebellopontine angle that distorted and compressed the right trigeminal root.
  • TECHNIQUE: The tumor was resected.
  • At operation, the trigeminal root appeared distorted and compressed by the tumor.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / ultrastructure. Demyelinating Diseases / etiology. Trigeminal Neuralgia / complications
  • [MeSH-minor] Adult. Analgesics, Non-Narcotic / therapeutic use. Carbamazepine / therapeutic use. Female. Humans. Neurosurgery / methods. Rhizotomy / methods

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  • (PMID = 20190659.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Non-Narcotic; 33CM23913M / Carbamazepine
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77. Furtado SV, Venkatesh PK, Dadlani R, Reddy K, Hegde AS: Adult medulloblastoma and the "dural-tail" sign: rare mimic of a posterior petrous meningioma. Clin Neurol Neurosurg; 2009 Jul;111(6):540-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult medulloblastoma and the "dural-tail" sign: rare mimic of a posterior petrous meningioma.
  • The role of magnetic resonance spectroscopy in the diagnosis of primitive neuroectodermal tumors is discussed.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Dura Mater / pathology. Infratentorial Neoplasms / pathology. Medulloblastoma / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Spectroscopy. Male. Petrous Bone. Treatment Outcome

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  • (PMID = 19285790.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 19
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78. Riazmontazer N, Daneshbod Y: Cytology of desmoplastic medulloblastoma in imprint smears: a report of 2 cases. Acta Cytol; 2006 Jan-Feb;50(1):97-100
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  • CASE REPORTS: A 22-year-old man and 27-year-old woman with a cerebellar tumor underwent craniotomy and tumor resection.
  • The cytology was misinterpreted as glial tumors, while the final histologic diagnosis in both cases were desmoplastic medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis
  • [MeSH-minor] Adult. Astrocytes / pathology. Brain Neoplasms / diagnosis. Diagnostic Errors. Female. Glioma / diagnosis. Humans. Intraoperative Period. Male. Neurons / pathology

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  • (PMID = 16514849.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Gelabert González M: [Posterior fossa hemangioblastomas]. Neurologia; 2007 Dec;22(10):853-9
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  • INTRODUCTION: Hemangioblastomas are histologically benign lesions that comprise 1-2 % of primary nervous system tumours and 8-12 % of all posterior fossa lesions in the adult.
  • Tumors were located on cerebellar hemisphere (17), cerebellar vermis (4) and brain stem (1).
  • Tumors were cyst in 16 cases, solid in 8 cases.
  • Total tumor removal was achieved in 21 patients (95 %), and incomplete removal in 1 cases.
  • CONCLUSIONS: Hemangioblastomas are benign tumors of uncertain origin that are located predominantly in the posterior cranial fossa and the spinal cord.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Hemangioblastoma / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Cranial Fossa, Posterior. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17671853.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] Spain
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80. Chang Q, Ng HK: [Different hypermethylation status of RASSF1A in medulloblastoma and supratentorial primitive neuroectodermal tumor]. Zhonghua Bing Li Xue Za Zhi; 2007 Jan;36(1):24-8
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  • [Title] [Different hypermethylation status of RASSF1A in medulloblastoma and supratentorial primitive neuroectodermal tumor].
  • OBJECTIVE: To investigate the epigenetic involvement of RASSF1A in intracranial primitive neuroectodermal tumors (PNETs) and compare the methylation patterns between medulloblastoma (MBs) and supratentorial PNETs (SPNETs).
  • RESULTS: The results revealed no promoter hypermethylation of RASSF1A in 2 normal cerebellar and 5 normal cerebral tissue specimens examined.
  • These results demonstrated that such epigenetic alteration was tumor-specific.
  • Different hypermethylation status of RASSF1A are found in PNET subtypes suggesting that MBs and SPNETs are epigenetical distinct tumors.
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Line, Tumor. Child. Child, Preschool. DNA Methylation. Female. Gene Expression Regulation, Neoplastic. Gene Silencing. HeLa Cells. Humans. Infant. Male. Promoter Regions, Genetic / genetics. Reverse Transcriptase Polymerase Chain Reaction. Young Adult


81. Ammerman JM, Lonser RR, Dambrosia J, Butman JA, Oldfield EH: Long-term natural history of hemangioblastomas in patients with von Hippel-Lindau disease: implications for treatment. J Neurosurg; 2006 Aug;105(2):248-55
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  • OBJECT: In the course of their lives most patients with von Hippel-Lindau (VHL) disease require treatment for several symptom-producing hemangioblastomas of the cerebellum, brainstem, or spinal cord.
  • However, many tumors never produce symptoms and do not require treatment.
  • Detection at an early stage of lesions that will later produce symptoms and ultimately require treatment would allow for earlier excision of hemangioblastomas of the spinal cord, brainstem, or cerebellum, and may identify cerebellar hemangioblastomas that can be treated with radiosurgery at a stage before treatment is contraindicated because of tumor size or the presence of an associated cyst.
  • Hemangioblastomas were located in the cerebellum (68 hemangioblastomas, 48% of patients), brainstem (17 hemangioblastomas, 12% of patients), and spinal cord (58 hemangioblastomas, 40% of patients).
  • Twenty-six (45%) of the hemangioblastomas that eventually produced symptoms were not among the tumors that were apparent on the initial MR imaging study.
  • Depending on location, the hemangioblastoma size and/or tumor and cyst growth rates predicted symptom development and the need for treatment (p < 0.05).
  • Cerebellar hemangioblastomas growing faster than 112 mm3/ month or larger than 69 mm3 with associated tumor and cyst growth rates greater than 14 mm3/month became symptomatic (100% sensitivity, 72% specificity).
  • Basing the decision to intervene in individual tumors solely on radiographic progression would have resulted in approximately four additional procedures per patient during the 10-year study period.
  • Threshold values are presented for tumor size and/or tumor and cyst growth rates that can be used to predict symptom formation and future need for treatment.
  • [MeSH-major] Brain Stem Neoplasms / diagnosis. Cerebellar Neoplasms / diagnosis. Hemangioblastoma / diagnosis. Magnetic Resonance Imaging. Spinal Cord Neoplasms / diagnosis. von Hippel-Lindau Disease / diagnosis
  • [MeSH-minor] Adult. Disease Progression. Early Diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neurologic Examination. Patient Care Planning. Prognosis

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  • (PMID = 17219830.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Mühlisch J, Bajanowski T, Rickert CH, Roggendorf W, Würthwein G, Jürgens H, Frühwald MC: Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses. J Neurooncol; 2007 May;83(1):17-29
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  • Certain risk groups among tumors of the central nervous system (CNS) in children take an almost inevitably fatal course.
  • Aberrant methylation is common in malignant brain tumors of childhood and may have implications for stratification and therapy.
  • Only p16 (INK4A )and TIMP3 were methylated consistently in medulloblastomas (p16 (INK4A ) 14%, TIMP3 11%) and p16 (INK4A) also in anaplastic ependymomas (1/4 tumors).
  • Therapeutic and diagnostic implications urge into depth analyses of methylation as a mechanism, which might fill some of the gaps of our understanding of brain tumor origin.
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. DNA Methylation. Genes, p16. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Tissue Inhibitor of Metalloproteinase-3 / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Apoptosis Regulatory Proteins / genetics. Calcium-Calmodulin-Dependent Protein Kinases / genetics. Child. Child, Preschool. Death-Associated Protein Kinases. Female. Gene Silencing. Humans. Infant. Male. Middle Aged. Nerve Tissue Proteins / genetics. Receptors, Immunologic / genetics

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  • (PMID = 17206475.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Nerve Tissue Proteins; 0 / Receptors, Immunologic; 0 / TIMP3 protein, human; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / roundabout protein; EC 2.7.11.1 / DAPK1 protein, human; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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83. Chamadoira C, Cerejo A, Duarte F, Vaz R: [Trigeminal neuralgia caused by contra lateral cerebellopontine angle tumor. A case report]. Neurocirugia (Astur); 2010 Feb;21(1):50-2
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  • [Title] [Trigeminal neuralgia caused by contra lateral cerebellopontine angle tumor. A case report].
  • [Transliterated title] Neuralgia del trigémino provocada por un tumor del ángulo ponto-cerebeloso contralateral. Caso clínico.
  • About 1% of cases, have trigeminal neuralgia associated with the presence of ipsilateral lesion of cerebellar-pontine angle.
  • Rarely, trigeminal neuralgia may be due to contralateral posterior fossa tumors.
  • Facial pain completely disappeared after tumor removal.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellopontine Angle / pathology. Neuroma, Acoustic / complications. Trigeminal Neuralgia / etiology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 20186375.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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84. Hartmann W, Digon-Söntgerath B, Koch A, Waha A, Endl E, Dani I, Denkhaus D, Goodyer CG, Sörensen N, Wiestler OD, Pietsch T: Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res; 2006 May 15;12(10):3019-27
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  • PURPOSE: Medulloblastomas represent the most frequent malignant brain tumors of childhood.
  • They are supposed to originate from cerebellar neural precursor cells.
  • Even more important, PTEN mRNA and protein levels were found to be significantly lower in medulloblastomas compared with normal cerebellar tissue of different developmental stages.
  • Reduction of PTEN expression was found to be associated with PTEN promoter hypermethylation in 50% of the tumor samples.
  • [MeSH-major] Cell Proliferation. Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. PTEN Phosphohydrolase / genetics. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism
  • [MeSH-minor] Adult. Child. DNA Mutational Analysis. Humans. Immunohistochemistry. Loss of Heterozygosity. Polymerase Chain Reaction. Polymorphism, Genetic. Signal Transduction. Tumor Cells, Cultured

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  • (PMID = 16707597.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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85. Schüller U, Koch A, Hartmann W, Garrè ML, Goodyer CG, Cama A, Sörensen N, Wiestler OD, Pietsch T: Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas. Int J Cancer; 2005 Oct 20;117(1):82-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent findings indicate that the chemokine receptor Cxcr4 is essential for normal development of the cerebellar cortex.
  • As medulloblastomas (MBs), the most common malignant brain tumors of childhood, are believed to arise from neuronal cerebellar precursors, we asked whether there is a potential role for Cxcr4 in the pathogenesis of MB.
  • In addition, a significant correlation of high CXCR4 mRNA levels and presence of the neurotrophin receptor p75NTR or expression of ATOH1 and GLI1 suggests that CXCR4 is a reliable marker for tumors derived from the cerebellar external granular layer.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Receptors, CXCR4 / genetics
  • [MeSH-minor] Adolescent. Adult. Amino Acid Substitution. Basic Helix-Loop-Helix Transcription Factors. Child. Child, Preschool. DNA / genetics. DNA Mutational Analysis. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic. Humans. Infant. Middle Aged. Mutation / genetics. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Oncogene Proteins / genetics. Oncogene Proteins / metabolism. Polymorphism, Single-Stranded Conformational. RNA / genetics. RNA, Messenger / analysis. Receptor, Nerve Growth Factor. Receptors, Nerve Growth Factor / genetics. Receptors, Nerve Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Trans-Activators. Transcription Factors / genetics. Transcription Factors / metabolism. Tumor Cells, Cultured

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15880586.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATOH1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / DNA-Binding Proteins; 0 / Gli protein; 0 / Nerve Tissue Proteins; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / Receptor, Nerve Growth Factor; 0 / Receptors, CXCR4; 0 / Receptors, Nerve Growth Factor; 0 / Trans-Activators; 0 / Transcription Factors; 63231-63-0 / RNA; 9007-49-2 / DNA
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86. Gyure KA: Newly defined central nervous system neoplasms. Am J Clin Pathol; 2005 Jun;123 Suppl:S3-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Newly defined central nervous system neoplasms.
  • In recent years, numerous new entities or variants of recognized central nervous system tumors have been described in the literature, and the morphologic spectrum of these neoplasms is delineated incompletely.
  • The clinicopathologic features and differential diagnosis of 4 new entities, including the chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and papillary glioneuronal tumor, are discussed in this review.
  • [MeSH-major] Central Nervous System Neoplasms / classification. Central Nervous System Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cerebellar Neoplasms / classification. Cerebellar Neoplasms / diagnosis. Child. Chordoma / classification. Chordoma / diagnosis. Diagnosis, Differential. Female. Ganglioglioma / classification. Ganglioglioma / diagnosis. Glioma / diagnosis. Glioma / pathology. Humans. Hypothalamic Neoplasms / classification. Hypothalamic Neoplasms / diagnosis. Male. Medulloblastoma / classification. Medulloblastoma / diagnosis. Prognosis. Rhabdoid Tumor / classification. Rhabdoid Tumor / diagnosis. Teratoma / classification. Teratoma / diagnosis. Third Ventricle / pathology

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  • (PMID = 16100866.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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87. Peltier J, Lok C, Fichten A, Bruniau A, Lefranc M, Toussaint P, Desenclos C, Le Gars D: Lhermitte-Duclos disease and Cowden's syndrome. Report of two cases. Neurochirurgie; 2006 Nov;52(5):407-14
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  • OBJECTIVE AND IMPORTANCE: Lhermitte-Duclos disease, or dysplastic cerebellar gangliocytoma is a rare entity characterized by a hamartomatous lesion in the posterior fossa.
  • Cowden's syndrome, or hamartoma-neoplasia syndrome is a rare underdiagnosed autosomal dominant genodermatosis with high incidence of malignant tumors.
  • CLINICAL PRESENTATION: We report two cases of Lhermitte-Duclos and Cowden disease occurring in adult patients.
  • An asymptomatic 38-year-old male had bilateral optic nerve drusen related to a cerebellar neoplasm.
  • A conservative strategy can be chosen without neurological signs because of slow tumor growth.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Ganglioneuroma / pathology. Ganglioneuroma / surgery. Hamartoma Syndrome, Multiple / pathology. Hamartoma Syndrome, Multiple / surgery
  • [MeSH-minor] Adult. Female. Fibrocystic Breast Disease / etiology. Fibrocystic Breast Disease / physiopathology. Goiter / complications. Humans. Intracranial Hypertension / etiology. Intracranial Hypertension / physiopathology. Magnetic Resonance Imaging. Male. Neurocutaneous Syndromes / pathology. Pedigree. Syndrome

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  • (PMID = 17185946.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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88. Deb P, Sharma MC, Gaikwad S, Gupta A, Mehta VS, Sarkar C: Cerebellopontine angle paraganglioma - report of a case and review of literature. J Neurooncol; 2005 Aug;74(1):65-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Majority of the cerebellopontine angle (CPA) tumors are acoustic neuromas, while bulk of the non-acoustic tumors are formed by meningiomas and epidermoid cysts.
  • Primary paraganglioma is a rare tumor in this location, with only two such cases having been reported in the literature, till date.
  • Recently, a case has been described wherein a paraganglioma was apparently arising as a primary lesion in the cerebellar hemisphere.
  • We report another case of an intracranial paraganglioma of the CPA in a 40-year-old female, which did not have any vascular attachment but had focal cerebellar extension.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Paraganglioma / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Microscopy, Electron, Transmission

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  • (PMID = 16078110.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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89. Alobid I, Gastón F, Morello A, Guilemany JM, Mullol J: Peripheral primitive neuroectodermal tumor of the cerebellopontine angle. Acta Otolaryngol; 2005 Apr;125(4):426-9

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  • [Title] Peripheral primitive neuroectodermal tumor of the cerebellopontine angle.
  • Peripheral primitive neuroectodermal tumors are highly malignant small cell neoplasms.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Ear, Inner / pathology. Ear, Inner / surgery. Female. Follow-Up Studies. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Retreatment

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  • (PMID = 15823816.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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90. Teider N, Scott DK, Neiss A, Weeraratne SD, Amani VM, Wang Y, Marquez VE, Cho YJ, Pomeroy SL: Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. Neuro Oncol; 2010 Dec;12(12):1244-56
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  • Human Neuralized1 (NEURL1) was investigated as a potential tumor suppressor in medulloblastoma (MB).
  • The gene is located at 10q25.1, a region demonstrating frequent loss of heterozygosity in tumors.
  • In addition, prior publications have shown that the Notch pathway is functional in a proportion of MB tumors and that Neurl1 is only expressed in differentiated cells in the developing cerebellum.
  • In this study, NEURL1 expression was downregulated in MB compared with normal cerebellar tissue, with the lowest levels of expression in hedgehog-activated tumors.
  • NEURL1-transfected MB cell lines demonstrated decreased population growth, colony-forming ability, tumor sphere formation, and xenograft growth compared with controls, and a significant increase in apoptosis was seen on cell cycle and cell death analysis.
  • From these studies, we conclude that NEURL1 is a candidate tumor suppressor in MB, at least in part through its effects on the Notch pathway.

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  • (PMID = 20847082.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / P30 HD018655; United States / NCI NIH HHS / CA / R01CA109467; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Calcium-Binding Proteins; 0 / Cell Cycle Proteins; 0 / HEY1 protein, human; 0 / Homeodomain Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Receptors, Notch; 134324-36-0 / Serrate proteins; 149348-15-2 / HES1 protein, human; EC 6.3.2.19 / NEURL1 protein, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
  • [Other-IDs] NLM/ PMC3018940
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91. Peña-Altamira E, Petazzi P, Contestabile A: Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous origin. Curr Pharm Des; 2010;16(4):440-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous origin.
  • Recent evidence suggests that nitric oxide (NO) has a remarkable anti-proliferative action towards dividing neural precursor cells as well as towards cells giving rise to neural-derived tumors.
  • The present paper summarizes essential literature-derived information on this issue and provides novel experimental evidence for these NO-mediated actions regarding a well characterized population of neuronal precursors, the cerebellar granule cell precursors and a cell line of medulloblastoma, a pediatric tumor originating from these same precursor cells undergoing deregulated proliferation.
  • Evidence is presented regarding the NO-mediated regulation of proliferation of neuronal precursor cells both during developmental and adult neurogenesis.
  • Then, the role of NO in the control of proliferation of neural-derived tumor cells, such as PC12 and neuroblastoma cells, is discussed.
  • Novel experimental data are provided documenting the anti-proliferative action of NO towards basal and mitogen-stimulated division of rat cerebellar granule cell precursors, as well as towards medulloblastoma DAOY cells.
  • Overall, the data presented and discussed here highlight similarities at the molecular level between physiologic processes regulating normal proliferation of neural precursors and pathologic deregulation of these processes leading to tumor formation.
  • [MeSH-major] Cell Proliferation. Neuroectodermal Tumors / pathology. Neurons / cytology. Nitric Oxide / metabolism

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  • (PMID = 20236073.001).
  • [ISSN] 1873-4286
  • [Journal-full-title] Current pharmaceutical design
  • [ISO-abbreviation] Curr. Pharm. Des.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 31C4KY9ESH / Nitric Oxide
  • [Number-of-references] 113
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92. Saran F, Baumert BG, Creak AL, Warrington AP, Ashley S, Traish D, Brada M: Hypofractionated stereotactic radiotherapy in the management of recurrent or residual medulloblastoma/PNET. Pediatr Blood Cancer; 2008 Mar;50(3):554-60
Genetic Alliance. consumer health - Medulloblastoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy in the management of locally recurrent or residual central nervous system (CNS) primitive neuroectodermal tumors (PNETs).
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Dose Fractionation. Medulloblastoma / radiotherapy. Neuroectodermal Tumors, Primitive / radiotherapy. Radiotherapy, Conformal / methods. Supratentorial Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Neoplasm Recurrence, Local / radiotherapy. Neoplasm, Residual. Palliative Care. Retrospective Studies. Stereotaxic Techniques

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17941071.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Gupta A, Ahmad FU, Sharma MC, Garg A, Mehta VS: Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report. J Neurosurg; 2007 Jun;106(6):1094-7
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  • [Title] Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report.
  • Meningeal melanocytomas are uncommon intracranial tumors and their occurrence at the cerebellopontine angle (CPA) is extremely rare.
  • The authors describe the case of a 58-year-old woman who presented with a left CPA tumor; on the basis of histopathological studies after resection, a diagnosis of meningeal melanocytoma was reached.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Melanoma / pathology. Melanoma / surgery. Meningioma / pathology. Meningioma / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Melanins / metabolism. Neurosurgical Procedures

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  • (PMID = 17564187.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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94. Piedimonte LR, Wailes IK, Weiner HL: Medulloblastoma: mouse models and novel targeted therapies based on the Sonic hedgehog pathway. Neurosurg Focus; 2005 Nov;19(5):E8
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In children, tumors of the central nervous system are thought to arise from progenitor cells that show considerable temporal and spatial heterogeneity in a developmental environment that is different from that of the adult.
  • Investigating the molecular basis of pediatric tumors is critical because it is likely to generate novel treatments.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Disease Models, Animal. Gene Targeting / methods. Medulloblastoma / genetics. Trans-Activators / genetics

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  • (PMID = 16398472.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA093450
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Shh protein, mouse; 0 / Trans-Activators
  • [Number-of-references] 64
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95. Tan CC, Gonzales M, Veitch A: Clinical implications of the infratentorial rosette-forming glioneuronal tumor: case report. Neurosurgery; 2008 Jul;63(1):E175-6; discussion E176

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical implications of the infratentorial rosette-forming glioneuronal tumor: case report.
  • OBJECTIVE: This article describes our experience with two patients who presented with unusual tumors in the cerebellar vermis and cerebral aqueduct.
  • Although sparing the fourth ventricle proper, both tumors had histological features consistent with the rare diagnosis of a rosette-forming glioneuronal tumor of the fourth ventricle, of which only 19 cases have been reported previously.
  • Patient 2 was a 38-year-old woman with a long history of intermittent giddiness, no neurological signs, and a magnetic resonance imaging scan that demonstrated a nonenhancing and subtle abnormality in the cerebellar vermis.
  • CONCLUSION: These cases demonstrate that the rosette-forming glioneuronal tumor may be more accurately categorized as an infratentorial tumor rather than a tumor of the fourth ventricle.
  • Because the literature indicates that this is a tumor with little potential for malignant behavior and considerable morbidity can accompany attempts at resection, a conservative management approach would seem well advised.
  • If this tumor is to be managed conservatively, because of the paucity of extended follow-up data, long-term radiological and clinical surveillance is strongly recommended.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / diagnosis. Infratentorial Neoplasms / diagnosis. Rosette Formation
  • [MeSH-minor] Adult. Female. Humans. Male

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  • (PMID = 18728557.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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96. Ishizawa K, Komori T, Hirose T: Stromal cells in hemangioblastoma: neuroectodermal differentiation and morphological similarities to ependymoma. Pathol Int; 2005 Jul;55(7):377-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An immunohistochemical and ultrastructural study was conducted for 17 cases of cerebellar hemangioblastoma.
  • In three cases, another component, known as a cellular variant, where epithelioid tumor cells were arranged in nests encircled by capillaries and/or in pseudorosette-like structures, was noted.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD / analysis. Antigens, CD56 / analysis. Antigens, CD57 / analysis. Cell Adhesion Molecules / analysis. Cell Differentiation. Child. Cytoskeletal Proteins. Diagnosis, Differential. Ependymoma / pathology. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Neuroectodermal Tumors / pathology. Phosphoproteins / analysis. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis. Vascular Endothelial Growth Factor A / analysis. Vascular Endothelial Growth Factor Receptor-2 / analysis. Vimentin / analysis

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  • (PMID = 15982211.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD56; 0 / Antigens, CD57; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Cytoskeletal Proteins; 0 / Phosphoproteins; 0 / S100 Proteins; 0 / Vascular Endothelial Growth Factor A; 0 / Vimentin; 0 / ezrin; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 4.2.1.11 / Phosphopyruvate Hydratase
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97. Daszkiewicz P, Maryniak A, Roszkowski M, Barszcz S: Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. Childs Nerv Syst; 2009 Jul;25(7):855-60
Genetic Alliance. consumer health - Pilocytic astrocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children.
  • PURPOSE: Increasing incidence of pediatric brain tumors and improving survival rates encouraged us to assess long-term functional outcome of patients with cerebellar juvenile pilocytic astrocytoma (JPA).
  • CONCLUSIONS: Long-term functional treatment outcome of cerebellar JPA is relatively favorable, in spite of permanent neurological deficits and emotional disorders in over half of the patients.
  • Vermian tumors are associated with worse long-term functional outcome.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cerebellum / surgery. Child. Child, Preschool. Education. Female. Follow-Up Studies. Humans. Infant. Male. Mood Disorders / etiology. Nervous System Diseases / etiology. Parents / psychology. Patient Satisfaction. Surveys and Questionnaires. Survival. Treatment Outcome. Young Adult

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  • (PMID = 19418058.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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98. Ammerman JM, Lonser RR, Oldfield EH: Posterior subtemporal transtentorial approach to intraparenchymal lesions of the anteromedial region of the superior cerebellum. J Neurosurg; 2005 Nov;103(5):783-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Posterior subtemporal transtentorial approach to intraparenchymal lesions of the anteromedial region of the superior cerebellum.
  • OBJECT: To overcome the limitations associated with surgical approaches that have been described for accessing intraparenchymal lesions of the anteromedial region of the superior cerebellum, the authors used a posterior subtemporal transtentorial approach to remove tumors in this region.
  • In this paper they describe the surgical technique that they used as well as the operative findings and clinical outcomes observed in patients who underwent resection of tumors in the anteromedial superior cerebellum.
  • METHODS: The consecutive patients with anteromedial superior cerebellar tumors who underwent resection performed using the posterior subtemporal transtentorial approach at the National Institutes of Health were included in this study.
  • Three patients (two men and one woman) with anteromedial superior cerebellar tumors (two hemangioblastomas and one pilocytic astrocytoma) underwent resection via this approach.
  • All the tumors were larger than 3 cm in diameter (range 3.1-3.5 cm).
  • This approach provided excellent surgical access and permitted complete tumor resection in each case.
  • CONCLUSIONS: The posterior subtemporal transtentorial approach provides excellent access to the anteromedial superior cerebellar region.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Cerebellum / surgery. Hemangioblastoma / surgery. Neurosurgical Procedures
  • [MeSH-minor] Adult. Cerebral Veins. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Temporal Lobe. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2006 May;104(5):854; author reply 855-6 [16703898.001]
  • [CommentIn] J Neurosurg. 2006 May;104(5):854-5; author reply 855-6 [16703899.001]
  • [CommentIn] J Neurosurg. 2005 Nov;103(5):776-7; discussion 777 [16304978.001]
  • (PMID = 16304980.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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99. Spiller SE, Ravanpay AC, Hahn AW, Olson JM: Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma. J Neurooncol; 2006 Sep;79(3):259-70
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Suberoylanilide hydroxamic acid (SAHA) has been studied in adult solid and hematologic malignancies.
  • However, little information has been reported on the effects of SAHA on central nervous system (CNS) tumors including medulloblastoma, the most common malignant brain tumor in children.
  • EXPERIMENTAL DESIGN AND RESULTS: Tissue culture studies were performed treating primary human fibroblasts, established medulloblastoma cell lines, and primary human medulloblastoma tumors with SAHA.
  • In athymic mice with medulloblastoma xenograft tumors, oral SAHA resulted in apoptosis of tumor tissue and significantly slowed tumor growth.
  • In the ND2:Smo transgenic mouse medulloblastoma model, SAHA treatment caused significant apoptosis in these cerebellar tumors.
  • CONCLUSIONS: SAHA effectively induces cell death in established medulloblastoma cell lines, human patient primary tumor cultures, medulloblastoma xenografts and intracranial spontaneous medulloblastomas.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cerebellar Neoplasms / drug therapy. Hydroxamic Acids / pharmacology. Medulloblastoma / drug therapy
  • [MeSH-minor] Animals. Apoptosis / drug effects. Cells, Cultured. Child. Fibroblasts / drug effects. Humans. In Situ Nick-End Labeling. Mice. Mice, Nude. Neoplasm Transplantation. Neoplasms, Experimental / drug therapy

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  • (PMID = 16645722.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA112350-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Hydroxamic Acids; 58IFB293JI / vorinostat
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100. Jiang YG, Xiang J, Wen F, Zhang LY: Microsurgical excision of the large or giant cerebellopontine angle meningioma. Minim Invasive Neurosurg; 2006 Feb;49(1):43-8
Genetic Alliance. consumer health - Meningioma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The tumors of 44 cases were all resected (Simpson I, II), with a total resection rate of 78.6%, and there was no operative mortality.
  • CONCLUSION: A rationally selected surgical approach, a microscopic technology applied in the operation to appropriately treat and protect vein, nerve and brain stem, which can ideally excise the tumors, together can increase the survival ability of patients.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle. Meningeal Neoplasms / surgery. Meningioma / surgery. Microsurgery
  • [MeSH-minor] Adolescent. Adult. Craniotomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 16547882.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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