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1. Korshunov AG, Sycheva RV, Gorelyshev SK, Ozerov SS, Golanov AV: [Chromosome 17 abnormalities in medulloblastomas and their prognostic value]. Zh Vopr Neirokhir Im N N Burdenko; 2008 Apr-Jun;(2):3-5; discussion 5
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  • The interphasic cytogenetic analysis of chromosome 17 abnormalities in medulloblastoma biopsy specimens may be recommended for its inclusion into a complex of laboratory diagnostic methods used in the examination of these tumors.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 17 / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Male. Predictive Value of Tests

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  • (PMID = 18724421.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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2. Kassam AB, Patel A, Welch W, Balzer J, Snyderman C, Hirsch B, Carrau R: The carotid-vertebral space: an 'extended' lateral window to the ventromedial cranial base and lower craniocervical junction. Ear Nose Throat J; 2005 May;84(5):312-5
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  • This "extended" lateral approach allows surgeons to resect very large tumors of the skull base through a single incision.
  • The operative field is more extensive than that achieved with other approaches; it extends from the cerebellar hemisphere to the extradural ventral upper cervical spine, and it provides access to tissue outside the spinal canal, such as the ventral strap muscles.
  • [MeSH-major] Hemangiopericytoma / surgery. Neurosurgical Procedures / methods. Skull Base Neoplasms / surgery
  • [MeSH-minor] Acyclovir. Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 15971756.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] X4HES1O11F / Acyclovir
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3. Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, von Bueren AO, Wittmann A, Schöttler A, Jorch N, Graf N, Kulozik AE, Witt O, Scheurlen W, von Deimling A, Rutkowski S, Taylor MD, Tabori U, Lichter P, Korshunov A, Pfister SM: TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma. J Clin Oncol; 2010 Dec 10;28(35):5188-96
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  • TP53 mutation status was not associated with unfavorable prognosis (P = .63) and was not linked to 17p allelic loss but was over-represented in the prognostically favorable WNT subgroup of MB as defined by CTNNB1 mutation (seven of 35 TP53-mutated tumors v 14 of 271 TP53 wild-type tumors; P = .005) and in tumors carrying high-level MYCN amplification (seven of 21 TP53-mutated tumors v 14 of 282 TP53 wild-type tumors; P = .001).
  • [MeSH-major] Biomarkers, Tumor / genetics. Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Comparative Genomic Hybridization. DNA Mutational Analysis. Female. Gene Amplification. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Mutation. Polymerase Chain Reaction. Prognosis. Tumor Suppressor Protein p53. Young Adult

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  • [CommentIn] J Clin Oncol. 2011 Apr 20;29(12):e344-6; author reply e347-8 [21357788.001]
  • (PMID = 21060032.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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4. Ishizawa K, Komori T, Hirose T: Stromal cells in hemangioblastoma: neuroectodermal differentiation and morphological similarities to ependymoma. Pathol Int; 2005 Jul;55(7):377-85
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  • An immunohistochemical and ultrastructural study was conducted for 17 cases of cerebellar hemangioblastoma.
  • In three cases, another component, known as a cellular variant, where epithelioid tumor cells were arranged in nests encircled by capillaries and/or in pseudorosette-like structures, was noted.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD / analysis. Antigens, CD56 / analysis. Antigens, CD57 / analysis. Cell Adhesion Molecules / analysis. Cell Differentiation. Child. Cytoskeletal Proteins. Diagnosis, Differential. Ependymoma / pathology. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged. Neuroectodermal Tumors / pathology. Phosphoproteins / analysis. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis. Vascular Endothelial Growth Factor A / analysis. Vascular Endothelial Growth Factor Receptor-2 / analysis. Vimentin / analysis

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  • (PMID = 15982211.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD56; 0 / Antigens, CD57; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Cytoskeletal Proteins; 0 / Phosphoproteins; 0 / S100 Proteins; 0 / Vascular Endothelial Growth Factor A; 0 / Vimentin; 0 / ezrin; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 4.2.1.11 / Phosphopyruvate Hydratase
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5. Gupta A, Ahmad FU, Sharma MC, Garg A, Mehta VS: Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report. J Neurosurg; 2007 Jun;106(6):1094-7
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  • [Title] Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report.
  • Meningeal melanocytomas are uncommon intracranial tumors and their occurrence at the cerebellopontine angle (CPA) is extremely rare.
  • The authors describe the case of a 58-year-old woman who presented with a left CPA tumor; on the basis of histopathological studies after resection, a diagnosis of meningeal melanocytoma was reached.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Melanoma / pathology. Melanoma / surgery. Meningioma / pathology. Meningioma / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Melanins / metabolism. Neurosurgical Procedures

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  • (PMID = 17564187.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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6. Hope AJ, Mansur DB, Tu PH, Simpson JR: Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma. Childs Nerv Syst; 2006 Sep;22(9):1201-7
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  • INTRODUCTION: Malignant brain tumors have been reported to occur after childhood irradiation more frequently than in the nonirradiated population.
  • [MeSH-major] Astrocytoma / diagnosis. Cerebellar Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Medulloblastoma / radiotherapy. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Radiotherapy Dosage. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 16570196.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 40
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7. Pascual-Castroviejo I, Pascual-Pascual SI, Viaño J, Carceller F, Gutierrez-Molina M, Morales C, Frutos-Martinez R: Posterior fossa tumors in children with neurofibromatosis type 1 (NF1). Childs Nerv Syst; 2010 Nov;26(11):1599-603
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  • [Title] Posterior fossa tumors in children with neurofibromatosis type 1 (NF1).
  • Four of them had astrocytomas but only in one case was the tumour primarily cerebellar while the tumour was primarily of the brain stem with invasion of the adjacent regions of one or both cerebellar hemispheres in three patients.
  • The patient with primary cerebellar astrocytoma is apparently cured 7 years after the removal of the tumour.
  • The patients with the brain stem tumours extending to the cerebellum, showed a chronic slowly progressive cerebellar disease, but remain alive at age of more than 20 years (one was lost to follow-up).
  • [MeSH-major] Cranial Fossa, Posterior. Neurofibromatosis 1 / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Astrocytoma / mortality. Astrocytoma / pathology. Astrocytoma / surgery. Brain Stem Neoplasms / diagnosis. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / surgery. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy. Male. Medulloblastoma / diagnosis. Medulloblastoma / mortality. Medulloblastoma / pathology. Medulloblastoma / surgery. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20464401.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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8. Kabacińska A, Dabrowska A, Tarnowska C, Cyryłowski L: [Diagnostic problems of rare cerebellopontine angle tumors]. Otolaryngol Pol; 2007;61(2):184-7
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  • [Title] [Diagnostic problems of rare cerebellopontine angle tumors].
  • Astrocytoma (neuroepithelial tumor) determine about 25% all the cerebroma but their original location in cerebellopontine angle is seldom.
  • In case of this kind of tumors in this place, the symptoms can be non-characteristic and similar to these, which appear in the acoustic neurinoma.
  • The most important in case of this diagnosis is both that this tumors can infiltrate of the brain tissues and the fact that they can transformate toward the anaplastic astrocytoma or glioblastoma multiforme (very malignant tumors).
  • MATERIAL AND METHODS: [corrected] A rare case of astrocytoma presenting as a cerebellopontine angle tumor is discussed.
  • The special characteristics of this tumor and unusual clinical course are disscused.
  • [MeSH-major] Astrocytoma / radiography. Astrocytoma / surgery. Cerebellar Neoplasms / radiography. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / radiography. Cerebellopontine Angle / surgery. Facial Nerve Diseases / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications. Treatment Outcome

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  • (PMID = 17668807.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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9. Marinovic T, Grahovac G, Habek M, Lambasa S, Tomac D: Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient. Clin Neuropathol; 2009 May-Jun;28(3):173-6
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  • [Title] Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient.
  • Multiple primary tumors in the central nervous system of different histological cell types are uncommon.
  • We report a patient who had pilocytic astrocytoma in the cerebellum and ependymoma in the cauda equina region, occurring simultaneously.
  • The suggested mechanism of this association is that primitive multipotent cells might have been displaced in the different CNS areas and developed in different tumor cells.
  • Multiplicity of primary CNS tumors should be considered in certain occasions, when clinical symptoms and signs are pointing in that direction.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Ependymoma / pathology. Neoplasms, Multiple Primary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Cauda Equina / pathology. Cauda Equina / surgery. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures

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  • (PMID = 19537133.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. Adachi M, Kawanami T, Ohshima H, Hosoya T: Cerebellar atrophy attributed to cerebellitis in two patients. Magn Reson Med Sci; 2005;4(2):103-7
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  • [Title] Cerebellar atrophy attributed to cerebellitis in two patients.
  • In a review of magnetic resonance (MR) images from patients with spinocerebellar degeneration (SCD), we found 2 rare patients considered to be in late-stage cerebellitis who showed isolated cerebellar atrophy.
  • The patients were negative for the spinocerebellar ataxia (SCA) genes and had no symptoms of hypothyroidism, history of malignant tumors, or history of alcohol and drug (phenytoin) abuse, which may cause cerebellar atrophy.
  • MR images demonstrated generalized atrophy of the cerebellum, excluding the brainstem or cerebrum.
  • In these cases, moreover, slightly high intensities were noted in the affected cerebellar cortices on fluid-attenuated inversion recovery (FLAIR) images.
  • [MeSH-major] Cerebellar Diseases / complications. Cerebellar Diseases / diagnosis. Magnetic Resonance Imaging / methods. Spinocerebellar Ataxias / etiology. Spinocerebellar Degenerations / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Fever / complications. Humans. Male

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  • (PMID = 16340165.001).
  • [ISSN] 1347-3182
  • [Journal-full-title] Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
  • [ISO-abbreviation] Magn Reson Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Curran EK, Le GM, Sainani KL, Propp JM, Fisher PG: Do children and adults differ in survival from medulloblastoma? A study from the SEER registry. J Neurooncol; 2009 Oct;95(1):81-85
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  • MB was defined strictly to exclude non-cerebellar primitive neuro-ectodermal tumors.
  • Similar outcomes between adult and childhood MB may justify inclusion of adults in pediatric cooperative trials for MB.
  • [MeSH-major] Cerebellar Neoplasms. Community Health Planning. Medulloblastoma / classification. Medulloblastoma / mortality
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Female. Humans. Male. Middle Aged. San Francisco / epidemiology. Survival Analysis. Young Adult

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  • (PMID = 19396401.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Attard TM, Giglio P, Koppula S, Snyder C, Lynch HT: Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. Cancer; 2007 Feb 15;109(4):761-6
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  • [Title] Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis.
  • They are at an increased risk of brain tumors, including cerebellar medulloblastoma, when compared with the general population (Brain Tumor Polyposis-BTP Type 2).
  • Genotype-phenotype correlations between APC gene mutations and central nervous system (CNS) tumors have, thus far not been successful.
  • METHODS: The authors analyzed their established hereditary CRC Registry for brain tumors in FAP pedigrees (56 families, 213 individuals), pooled their patients with BTP and known APC mutations with those reported thus far elsewhere, and compared the resulting mutation distribution of FAP-BTP with the mutation distribution for APC mutations in the US.
  • RESULTS: Twenty-eight patients from 24 families were accrued, the most common brain tumor in BTP was medulloblastoma (60%) predominantly in females (12:5) under the age of 20 (mean age 14.7 SD 9.2).
  • Analysis of the pooled APC mutation data by Chi-square test of association shows an odds ratio of 3.7 (P < .005) for all brain tumor subtypes and 13.1 (P < .001) for medulloblastoma in patients harboring segment 2 APC mutation (codons 679-1224) compared to nonsegment 2 mutation.
  • CONCLUSIONS: In patients with FAP and identifiable APC gene mutation, CNS tumors, especially medulloblastoma which developed in most cases during childhood, are more common in females with FAP and APC gene mutation in codons 686-1217.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli Protein / genetics. Brain Neoplasms / complications. Mutation / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Codon. Female. Humans. Male. Pedigree. Registries


13. Lonser RR, Vortmeyer AO, Butman JA, Glasker S, Finn MA, Ammerman JM, Merrill MJ, Edwards NA, Zhuang Z, Oldfield EH: Edema is a precursor to central nervous system peritumoral cyst formation. Ann Neurol; 2005 Sep;58(3):392-9
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  • Serial MRI was correlated with the clinical findings in 16 von Hippel-Lindau disease patients with 22 CNS hemangioblastomas (11 spinal cord; 11 cerebellar) that were associated with the appearance and evolution of peritumoral cysts.
  • MRI clearly showed peritumoral edema that developed and slowly and progressively evolved into enlarging hemangioblastoma-associated cysts in all tumors (mean follow-up, 130 +/- 38 months; mean +/- standard deviation).
  • CNS peritumoral cyst formation is initiated by increased tumor vascular permeability, increased interstitial pressure in the tumor, and plasma extravasation with convective distribution into the surrounding tissue.
  • When the delivery of plasma from the tumor exceeds the capacity of the surrounding tissue to absorb the extravasated fluid, edema (with its associated increased interstitial pressure) and subsequent cyst formation occur.
  • [MeSH-major] Brain Neoplasms / pathology. Central Nervous System Cysts / pathology. Edema / pathology
  • [MeSH-minor] Adult. Autopsy / methods. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging / methods. Male. Time Factors. Vascular Endothelial Growth Factor A / blood. Vascular Endothelial Growth Factor A / cerebrospinal fluid

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  • (PMID = 16130092.001).
  • [ISSN] 0364-5134
  • [Journal-full-title] Annals of neurology
  • [ISO-abbreviation] Ann. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A
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14. Basu S, Rubello D: PET imaging in the management of tumors of testis and ovary: current thinking and future directions. Minerva Endocrinol; 2008 Sep;33(3):229-56
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  • [Title] PET imaging in the management of tumors of testis and ovary: current thinking and future directions.
  • Of these, the area where FDG-PET imaging has been examined the most in testicular tumors is the evaluation of postchemotherapy residual mass in both seminoma and nonseminomatous germ cell tumors (NSGCT) of the testis, a critical step in determining the subsequent management approach of these tumors that vary amongst various centers.
  • [MeSH-major] Ovarian Neoplasms / radionuclide imaging. Positron-Emission Tomography. Testicular Neoplasms / radionuclide imaging
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Clinical Trials as Topic. Combined Modality Therapy. Cost-Benefit Analysis. Female. Follow-Up Studies. Forecasting. Humans. Lymphoma, Non-Hodgkin / radionuclide imaging. Lymphoma, Non-Hodgkin / therapy. Male. Middle Aged. Neoplasm Staging / methods. Neoplasms, Germ Cell and Embryonal / radionuclide imaging. Neoplasms, Germ Cell and Embryonal / therapy. Paraneoplastic Cerebellar Degeneration / radionuclide imaging. Prognosis. Prospective Studies. Radiopharmaceuticals. Retrospective Studies

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  • (PMID = 18846028.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Number-of-references] 83
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15. Masunaga K, Inadome A, Sugiyama Y, Maeda Y, Satoji Y, Takahashi W, Yoshida M, Ueda S, Ikeda K, Takano Y, Yatsuda J: [Bilateral pheochromocytomas with von Hippel-Lindau disease: a case report]. Nihon Hinyokika Gakkai Zasshi; 2007 Nov;98(7):843-7
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  • Computed tomography revealed bilateral adrenal tumors and noradrenalin levels in serum and urine were elevated.
  • Moreover, he had cerebellar and spinal hemangioblastomas.
  • Bilateral adrenalectomies and left nephrectomy were performed because tumor thrombus extended into the left renal vein, and pathological diagnosis was pheochromocytoma.
  • We diagnosed the patient as VHL disease because of the existence of cerebellar and spinal hemangioblastomas, bilateral pheochromocytomas, missense mutation and his family history.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / complications. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / diagnosis
  • [MeSH-minor] Adrenalectomy. Adult. Diagnostic Imaging. Female. Humans. Male. Mutation, Missense. Siblings

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  • (PMID = 18062217.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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16. Korshunov A, Benner A, Remke M, Lichter P, von Deimling A, Pfister S: Accumulation of genomic aberrations during clinical progression of medulloblastoma. Acta Neuropathol; 2008 Oct;116(4):383-90
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  • Medulloblastomas comprise the most frequent malignant brain tumor in childhood and one of the biggest challenges in pediatric oncology.
  • The current concept suggests that these tumors may undergo stepwise progression as it has been shown for other brain tumors.
  • In the present study, 28 pairs of medulloblastoma at primary diagnosis and at the time of recurrence, either occurring as local tumor regrowth or tumor dissemination, were histopathologically and molecularly analyzed.
  • Cytogenetic analysis included interphase fluorescence in situ hybridization for five genomic loci (MYC, MYCN, 17p, 17q, 6q) that have previously been identified as prognostic markers in primary tumors.
  • Of 16 tumors showing early recurrence (<4 years after first diagnosis), only one showed increased histological anaplasia in the secondary lesion (6%), and two acquired genomic lesions indicative for a more malignant phenotype (13%).
  • In contrast to this, of 12 tumors with a time to recurrence of 4 years or more, nine tumors (75%) showed a more malignant phenotype either reflected by increased anaplasia alone or by both increased anaplasia and acquirement of genomic aberrations known to be associated with inferior patient outcome.
  • These results suggest that early recurrence in medulloblastoma mainly occurs in tumors with a highly malignant genotype and phenotype per se, whereas late recurrence is often dependent on tumor evolution toward a more malignant biology.
  • Therefore, biopsy of recurrent tumors should be performed to assess the biologic properties of the relapsed tumor, especially when targeted therapy approaches are considered.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 17 / genetics. Chromosomes, Human, Pair 6 / genetics. Medulloblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. Proto-Oncogene Proteins c-myc / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Cytogenetic Analysis. Disease Progression. Female. Humans. Male. Neoplasm Recurrence, Local / genetics. Prognosis

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  • (PMID = 18704466.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYC protein, human; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Proto-Oncogene Proteins c-myc
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17. Zhou LF, Du G, Mao Y, Zhang R: Diagnosis and surgical treatment of brainstem hemangioblastomas. Surg Neurol; 2005 Apr;63(4):307-15; discussion 315-6
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  • (1) patients with a single tumor on the brainstem which was verified by surgery and pathology;.
  • Tumors were located on oblongata (14), ponto-oblongata (9), pons (6), and cervicomedulla (4).
  • Tumors were solid in 29 cases, cyst in 4 cases, and had a small size in 5 (< or =3 cm), large in 19 (3.1-4 cm), and giant in 9 (>4 cm).
  • Total tumor removal was achieved in 31 patients (94%), and incomplete removal in 2 cases.
  • Two patients with EBS type and giant solid tumors died after operation.
  • A combined strategy of preoperative embolization, mild hypothermia with or without hypotension, microsurgical technique, and intensive perioperative management are mandatory for removal of these kinds of tumors with acceptable morbidity and mortality.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellar Neoplasms / therapy. Embolization, Therapeutic. Hemangioblastoma / surgery. Hemangioblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Humans. Hyperthermia, Induced. Hypotension. Male. Middle Aged. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 15808704.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Jalali R, Mallick I, Dutta D, Goswami S, Gupta T, Munshi A, Deshpande D, Sarin R: Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):974-9
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  • [Title] Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy.
  • PURPOSE: To present the effect of radiotherapy doses to different volumes of normal structures on neurocognitive outcomes in young patients with benign and low-grade brain tumors treated prospectively with stereotactic conformal radiotherapy (SCRT).
  • METHODS AND MATERIALS: Twenty-eight patients (median age, 13 years) with residual/progressive brain tumors (10 craniopharyngioma, 8 cerebellar astrocytoma, 6 optic pathway glioma and 4 cerebral low-grade glioma) were treated with SCRT to a dose of 54 Gy in 30 fractions over 6 weeks.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Cognition Disorders / etiology. Glioma / radiotherapy. Intelligence / radiation effects
  • [MeSH-minor] Adolescent. Astrocytoma / radiotherapy. Cerebellar Neoplasms / psychology. Cerebellar Neoplasms / radiotherapy. Child. Cognition / radiation effects. Craniopharyngioma / psychology. Craniopharyngioma / radiotherapy. Female. Humans. Male. Optic Nerve Glioma / radiotherapy. Prospective Studies. Radiotherapy, Conformal / methods. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19864079.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Glassmann A, Molly S, Surchev L, Nazwar TA, Holst M, Hartmann W, Baader SL, Oberdick J, Pietsch T, Schilling K: Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells. BMC Dev Biol; 2007;7:111
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  • [Title] Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells.
  • BACKGROUND: Mtss1 encodes an actin-binding protein, dysregulated in a variety of tumors, that interacts with sonic hedgehog/Gli signaling in epidermal cells.
  • Given the prime importance of this pathway for cerebellar development and tumorigenesis, we assessed expression of Mtss1 in the developing murine cerebellum and human medulloblastoma specimens.
  • In the adult CNS, Mtss1 is found exclusively in cerebellar Purkinje cells.
  • Whereas immature granule cells express a Mtss1 variant observed also in peripheral tissues and comprising exon 12, this exon is replaced by a CNS-specific exon, 12a, in more mature granule cells and in adult Purkinje cells.
  • Bioinformatic analysis of Mtss1 suggests that differential exon usage may affect interaction with Fyn and Src, two tyrosine kinases previously recognized as critical for cerebellar cell migration and histogenesis.
  • CONCLUSION: Both the pattern of expression and splicing of Mtss1 is developmentally regulated in the murine cerebellum.
  • These findings are discussed with a view on the potential role of Mtss1 for cytoskeletal dynamics in developing and mature cerebellar neurons.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Cerebellum / growth & development. Gene Expression Regulation, Developmental. Microfilament Proteins / genetics. Neoplasm Proteins / genetics
  • [MeSH-minor] Animals. Cerebellar Neoplasms / pathology. Exons. Humans. Mice. Mice, Inbred C57BL. Mice, Transgenic. Polymerase Chain Reaction. Protein Splicing / genetics. Purkinje Cells / pathology. Tumor Cells, Cultured

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  • (PMID = 17925019.001).
  • [ISSN] 1471-213X
  • [Journal-full-title] BMC developmental biology
  • [ISO-abbreviation] BMC Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Microfilament Proteins; 0 / Mtss1 protein, mouse; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2194783
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20. Vieira Santos A, Vilela P, Mateus L, Saraiva PF, Goulão A: [Central nervous system abnormalities namely secondary brain tumors]. Acta Med Port; 2006 Nov-Dec;19(6):451-4
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  • [Title] [Central nervous system abnormalities namely secondary brain tumors].
  • [Transliterated title] Tumor do sistema nervoso central secundário a radioterapia e quimioterapia.
  • Eighteen years later a cerebellar glioblastoma multiforme was diagnosed.
  • The authors speculate about the possibility that this tumor may have been radiation and/or chemotherapy induced.
  • [MeSH-major] Brain Neoplasms / diagnosis. Glioblastoma / diagnosis. Neoplasms, Second Primary / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17583602.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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21. Abe M, Tokumaru S, Tabuchi K, Kida Y, Takagi M, Imamura J: Stereotactic radiation therapy with chemotherapy in the management of recurrent medulloblastomas. Pediatr Neurosurg; 2006;42(2):81-8
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  • Medulloblastomas are highly lethal tumors when they recur.
  • The reduction in tumor size after SRT was often remarkable.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / therapy. Medulloblastoma / therapy. Neoplasm Recurrence, Local / therapy. Radiosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Cisplatin / administration & dosage. Dose-Response Relationship, Drug. Etoposide / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Male. Peripheral Blood Stem Cell Transplantation. Radiotherapy Dosage. Retrospective Studies

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16465076.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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22. Kramer K, Humm JL, Souweidane MM, Zanzonico PB, Dunkel IJ, Gerald WL, Khakoo Y, Yeh SD, Yeung HW, Finn RD, Wolden SL, Larson SM, Cheung NK: Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8. J Clin Oncol; 2007 Dec 1;25(34):5465-70
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  • PURPOSE: Tumors metastasizing to the CNS and leptomeninges (LM) are associated with significant mortality.
  • Tumor response was determined by clinical, radiographic, and cytologic criteria.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Immunoglobulin G / immunology. Immunotoxins / administration & dosage. Iodine Radioisotopes / administration & dosage. Meningeal Neoplasms / radiotherapy. Radioimmunotherapy / methods
  • [MeSH-minor] Adolescent. Adult. Animals. Cerebellar Neoplasms / immunology. Cerebellar Neoplasms / radionuclide imaging. Cerebellar Neoplasms / radiotherapy. Child. Child, Preschool. Humans. Infant. Medulloblastoma / immunology. Medulloblastoma / radionuclide imaging. Medulloblastoma / radiotherapy. Mice. Mice, Inbred BALB C. Middle Aged. Neuroblastoma / immunology. Neuroblastoma / radionuclide imaging. Neuroblastoma / radiotherapy

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  • (PMID = 18048828.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA72868
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 3F8 antibody; 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 0 / Immunotoxins; 0 / Iodine Radioisotopes
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23. Sherman JH, Sheehan JP, Elias WJ, Jane JA Sr: Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases. Surg Neurol; 2005 May;63(5):476-9
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  • [Title] Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases.
  • BACKGROUND: Mutism has been associated with injury to midline cerebellar structures secondary to degenerative disease, tumors, hemorrhage, or surgery.
  • Typically, cerebellar mutism syndrome (CMS) has been seen in children and only rarely described in adults after surgery of the posterior fossa.
  • CASE DESCRIPTION: The authors report on 2 patients each of whom developed cerebellar mutism after tumor resection using a posterior fossa approach.
  • The first patient underwent gross total resection of a pineal region tumor via a supracerebellar approach.
  • The second patient underwent posterior fossa decompression for a left cerebellar hemispheric renal cell carcinoma metastasis with adjacent hemorrhage.
  • One patient displayed a variant of cerebellar mutism with severe ataxic dysarthria without complete absence of speech, whereas the other demonstrated frank mutism.
  • CONCLUSION: It is paramount that neurosurgeons be aware of cerebellar mutism with regard to its very rare occurrence in adults, its time of onset, and typical self-limiting course.
  • [MeSH-major] Brain Neoplasms / surgery. Carcinoma, Renal Cell / surgery. Cerebellum / surgery. Cranial Fossa, Posterior / surgery. Dermoid Cyst / surgery. Mutism / etiology. Neurosurgical Procedures / adverse effects
  • [MeSH-minor] Adult. Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / secondary. Cerebellar Neoplasms / surgery. Decompression, Surgical / adverse effects. Female. Humans. Kidney Neoplasms / pathology. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual. Pinealoma / pathology. Pinealoma / surgery. Postoperative Complications / etiology. Postoperative Complications / pathology. Radiosurgery. Radiotherapy. Treatment Outcome

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  • [CommentIn] Surg Neurol. 2006 Apr;65(4):424 [16531220.001]
  • (PMID = 15883080.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Tella OI, Stavale JN, Herculano MA, Paiva Neto MA, Onishi FJ, Guimarães Filho Fde A, Silva LR: [Size and proliferative index correlation in acoustic neuromas]. Arq Neuropsiquiatr; 2006 Mar;64(1):72-6
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  • Acoustic neuromas are the most common tumors in the cerebellopontine angle.
  • The molecular mechanisms involved in generation and growth of these tumors are not completely elucidated.
  • Many radiological, clinic and immunohistochemistry data were correlated to tumor growth.
  • The size of the tumors were positively correlationated with proliferative index.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Ki-67 Antigen / analysis. Neoplasm Proteins / analysis. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Age Distribution. Age Factors. Aged. Cell Proliferation. Cell Size. Female. Humans. Immunohistochemistry. Middle Aged. Mitotic Index. Neoplasm Invasiveness. Statistics, Nonparametric

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  • (PMID = 16622557.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins
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25. Li ZQ, Lan Q: [Microsurgical anatomy and quantitative assessment of suboccipital median transcerebellomedullary fissure keyhole approach]. Zhonghua Yi Xue Za Zhi; 2009 Oct 27;89(39):2754-8
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  • METHODS: Six 10% formaldehyde-fixed adult cadaveric head and neck specimens injected with colored latex were chosen for the study.
  • Thus it can be used to remove the tumors located in the fourth ventricle, dorsum of pons and medullary oblongata and cerebellar vermis.
  • [MeSH-major] Cerebellum / anatomy & histology. Cisterna Magna / anatomy & histology. Microsurgery. Occipital Bone / anatomy & histology
  • [MeSH-minor] Adult. Humans

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  • (PMID = 20137597.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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26. Sun YJ, Yu SZ, Sun CY, Wang Q, Jin SM, Wu WX, An TL: [Detection of chromosomal DNA imbalance in medulloblastoma by comparative genomic hybridization]. Zhonghua Bing Li Xue Za Zhi; 2010 Sep;39(9):606-10
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  • Eleven gain zones (+5q, +6q, +7q, +11q, +15q, +17p, +17q, +19q, +20q, +21q, +Xp) and twenty-five loss zones (-1p, -1q, -2p, -2q, -3q, -4p, -6p, -6q, -8p, -8q, -10p, -10q, -11p, -14q, -16p, -16q, -17p, -18p, -18q, -19p, -19q, -20p, -20q, -Xp, -Xq) were detected in those tumors.
  • +7q, +17q, -14q and -10q correlate closely to development of the tumors.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Chromosome Deletion. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Comparative Genomic Hybridization. DNA, Neoplasm / genetics. Female. Humans. Male. Sex Factors. Young Adult

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  • (PMID = 21092588.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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27. Bedre G, Gupta T, Rajasekharan P, Munshi A, Jalali R: Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns? JOP; 2007;8(4):444-9
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  • [Title] Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns?
  • Cerebellar and pancreatic metastases from tumors of mesenchymal origin such as soft tissue sarcomas are exceptional, more so in the absence of pulmonary metastases.
  • An MRI brain scan was suggestive of a solitary cerebellar metastasis.
  • CONCLUSION: Cerebellar, pancreatic, and paraspinal metastases from soft tissue sarcomas are rare, especially in the absence of pulmonary metastases.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Pancreatic Neoplasms / secondary. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17625297.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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28. Choi YL, Kim CJ, Matsuo T, Gaetano C, Falconi R, Suh YL, Kim SH, Shin YK, Park SH, Chi JG, Thiele CJ: HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. J Neurooncol; 2005 May;73(1):19-27
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  • [Title] HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors.
  • HUlip is highly expressed only in the fetal brain and spinal cord, and is undetected in the adult brain.
  • The purpose of this study was to investigate the pattern of hUlip expression in the developing human brain and nervous system tumors.
  • Ten human brains at different developmental stages and 118 cases of nervous system tumor tissues were examined by immunohistochemistry.
  • Twelve related tumor cell lines were also analyzed by northern blotting and immunoblotting.
  • HUlip was expressed in late fetal and early postnatal brains; strongly in the neurons of the brain stem, basal ganglia/thalamus, and dentate gyrus of the hippocampus, and relatively weakly in the cerebral and cerebellar cortex.
  • Among tumors, hUlip expression was easily detected in tumor cells undergoing neuronal differentiation such as ganglioneuroblastomas and ganglioneuromas.
  • Furthermore, hUlip immunoreactivity was also found in various brain tumors showing neuronal differentiation: central neurocytomas (6 of 6 cases were positive), medulloblastomas (5/11), atypical teratoid rhabdoid tumor (1/1) and gangliogliomas (4/7).
  • Some astrocytic tumors also showed weak positivity: astrocytomas (1 of 5 cases), anaplastic astrocytomas (2/5), and glioblastomas (3/11).
  • The results of this study indicate that the expression of hUlip protein is distinctly restricted to the late fetal and early postnatal periods of human nervous system development and to certain subsets of nervous system tumors.
  • The exact function of hUlip needs to be further clarified; yet the results of our study strongly imply that hUlip function is important in human nervous system development and its aberrant expression in various types of nervous system tumors suggests a role of hUlip as an oncofetal neural antigen.
  • [MeSH-major] Brain / metabolism. Brain Neoplasms / metabolism. Gene Expression Regulation, Developmental / physiology. Gene Expression Regulation, Neoplastic / physiology. Muscle Proteins / metabolism
  • [MeSH-minor] Astrocytes / cytology. Astrocytes / metabolism. Cell Differentiation / genetics. Cell Differentiation / physiology. Cell Line, Tumor. Female. Gestational Age. Humans. Immunohistochemistry. Male. Neuroblastoma / genetics. Neuroblastoma / metabolism. Neurons / cytology. Neurons / metabolism

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  • (PMID = 15933812.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DPYSL3 protein, human; 0 / Muscle Proteins
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29. Bobest M, Tóth C, Gyurcsó M, Molnár MJ, Garzuly F: [Nonsense mutation 193C&gt;T of neurofibromatosis type 2--a neurosurgical challenge]. Ideggyogy Sz; 2007 Jan 20;60(1-2):41-5
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  • Two years later severe cerebellar ataxia and left sided anacusis developed.
  • MRI revealed bilateral vestibularis tumors and multiple cervical intradural extramedullary myelin compressing lesions.
  • After partial resection of the huge left sided cerebello-pontine tumor, histologically schwannoma, and the extirpation of the multiple cervical meningiomas the patient died three months later due to septic complications.
  • [MeSH-minor] Adolescent. Adult. Cytosine. Female. Humans. Magnetic Resonance Imaging. Male. Thymine. Tomography, X-Ray Computed

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  • (PMID = 17432093.001).
  • [ISSN] 0019-1442
  • [Journal-full-title] Ideggyógyászati szemle
  • [ISO-abbreviation] Ideggyogy Sz
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Codon, Nonsense; 8J337D1HZY / Cytosine; QR26YLT7LT / Thymine
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30. Wyss MT, Hofer S, Hefti M, Bärtschi E, Uhlmann C, Treyer V, Roelcke U: Spatial heterogeneity of low-grade gliomas at the capillary level: a PET study on tumor blood flow and amino acid uptake. J Nucl Med; 2007 Jul;48(7):1047-52
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  • [Title] Spatial heterogeneity of low-grade gliomas at the capillary level: a PET study on tumor blood flow and amino acid uptake.
  • We used PET with (18)F-fluoro-ethyl-l-tyrosine (FET) to measure the spatial distribution of the amino acid carrier, which is located at the brain capillaries, and (15)O-H(2)O to measure tumor CBF.
  • Region-of-interest (ROI) analysis was used to quantify tumor tracer uptake, which was normalized to cerebellar uptake (tumor-to-cerebellum ratio).
  • "Active" tumor was defined as tumor having a radioactivity concentration that was at least 110% of the cerebellar activity.
  • This threshold provided measures of active tumor volume, global and peak tumor CBF, and (18)F-FET uptake.
  • Trace ROIs were applied to create voxelwise profiles of CBF and (18)F-FET uptake across tumor and brain.
  • RESULTS: Fourteen of 17 tumors showed increased global CBF and (18)F-FET uptake.
  • Active tumor volumes ranged between 3 and 270 cm(3) for (18)F-FET and between 1 and 41 cm(3) for CBF.
  • Global (18)F-FET uptake in tumors corresponded to CBF increases (Spearman rank rho = 0.771, P < 0.01).
  • Trace ROIs showed that irrespective of increased (18)F-FET uptake at the tumor periphery, CBF increases were more confined to the tumor center.
  • Within individual tumors, spatial heterogeneity was present.
  • Particular tumors infiltrating the corpus callosum showed low CBF and (18)F-FET uptake in this tumor region.
  • The patterns observed with PET were not reflected on MRI of the tumors, all of which presented as homogeneous non-gadolinium-enhancing lesions.
  • CONCLUSION: Low-grade gliomas are heterogeneous tumors with regard to the distribution of amino acid uptake and CBF.
  • Both are coupled in the tumor center.
  • At the tumor periphery, where tumor infiltration of surrounding brain occurs, CBF may be low irrespective of increased (18)F-FET uptake.
  • [MeSH-major] Brain Neoplasms / blood supply. Glioma / blood supply. Radiopharmaceuticals / pharmacokinetics. Tyrosine / analogs & derivatives
  • [MeSH-minor] Adult. Amino Acid Transport Systems / metabolism. Capillaries / metabolism. Capillaries / radionuclide imaging. Cerebellum / blood supply. Cerebellum / metabolism. Cerebellum / radionuclide imaging. Female. Fluorine Radioisotopes. Humans. Male. Microcirculation / metabolism. Microcirculation / radionuclide imaging. Middle Aged. Oxygen Isotopes. Oxygen Radioisotopes. Positron-Emission Tomography. Water

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  • (PMID = 17574979.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acid Transport Systems; 0 / Fluorine Radioisotopes; 0 / O-(2-fluoroethyl)tyrosine; 0 / Oxygen Isotopes; 0 / Oxygen Radioisotopes; 0 / Radiopharmaceuticals; 059QF0KO0R / Water; 42HK56048U / Tyrosine
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31. Vajtai I, Arnold M, Kappeler A, Jeless O, Lukes A, Mariani L, Paulus W: Rosette-forming glioneuronal tumor of the fourth ventricle: report of two cases with a differential diagnostic overview. Pathol Res Pract; 2007;203(8):613-9
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  • [Title] Rosette-forming glioneuronal tumor of the fourth ventricle: report of two cases with a differential diagnostic overview.
  • We report on clinicopathological findings in two cases of rosette-forming glioneuronal tumor of the fourth ventricle (RGNT) occurring in females aged 16 years (Case 1) and 30 years (Case 2).
  • Symptoms included vertigo, nausea, cerebellar ataxia, as well as headaches, and had been present for 4-months and 1 week, respectively.
  • Magnetic resonance imaging (MRI) indicated a cerebellar-based tumor of 1.8 cm (Case 1) and 5 cm (Case 2) diameter each, bulging into the fourth ventricle.
  • On microscopy, both tumors comprised an admixture of low-grade astrocytoma interspersed with circular aggregates of synaptophysin-expressing round cells harboring oligodendrocyte-like nuclei.
  • Cerebellar parenchyma included in the surgical specimen did not reveal any preexisting malformative anomaly.
  • Despite sharing some overlapping histologic traits with dysembryoplastic neuroepithelial tumor (DNT), the presentation of RGNT with respect to both patient age and location is consistent enough for this lesion to be singled out as an autonomous entity.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Ganglioglioma / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neurosurgical Procedures. Synaptophysin / metabolism

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  • (PMID = 17651910.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Synaptophysin
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32. Jarrell ST, Vortmeyer AO, Linehan WM, Oldfield EH, Lonser RR: Metastases to hemangioblastomas in von Hippel-Lindau disease. J Neurosurg; 2006 Aug;105(2):256-63
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  • OBJECT: Patients with hereditary cancer syndromes may be at increased risk for the development of tumor-to-tumor metastases.
  • Metastasis to a CNS hemangioblastoma was found in six resected tumors (8% of all hemangioblastomas resected from patients with VHL disease at the NINDS during the study period) from six patients (five women, one man; mean age at surgery 42.5 years).
  • The primary site of metastatic disease was the kidney in five patients (renal cell carcinoma) and the pancreas in one (a pancreatic neuroendocrine tumor).
  • Emerging histopathological techniques may lead to recognition of an increasing number of cases of tumor-to-hemangioblastoma metastasis.
  • Management of cases involving tumor-to-hemangioblastoma metastases in VHL disease should be based on the histological characteristics of the primary tumor, extent of the primary disease, and completeness of the resection.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Carcinoma, Renal Cell / secondary. Cerebellar Neoplasms / secondary. Hemangioblastoma / diagnosis. Kidney Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Neuroendocrine Tumors / secondary. Pancreatic Neoplasms / diagnosis. Pheochromocytoma / secondary. Spinal Cord Neoplasms / secondary. von Hippel-Lindau Disease / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Brain / pathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / diagnosis. Spinal Cord / pathology. Tomography, X-Ray Computed


33. Low JA, de Sauvage FJ: Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol; 2010 Dec 20;28(36):5321-6
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  • A number of tumor types rely on overexpression of Hh ligands to activate the pathway in a paracrine manner from the tumor to the surrounding stroma.
  • However, the role of the Hh pathway is best established in tumors, such as basal cell carcinoma and medulloblastoma, where the pathway is activated via mutations.
  • Understanding the contribution of Hh signaling in these various tumor types will be critical to the development and use of agents targeting this pathway in the clinic.
  • [MeSH-major] Anilides / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Basal Cell / drug therapy. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Pyridines / therapeutic use. Skin Neoplasms / drug therapy
  • [MeSH-minor] Adult. Child. Hedgehog Proteins / antagonists & inhibitors. Hedgehog Proteins / physiology. Humans. Paracrine Communication / physiology. Receptors, G-Protein-Coupled / physiology. Signal Transduction

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  • (PMID = 21041712.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anilides; 0 / Antineoplastic Agents; 0 / Hedgehog Proteins; 0 / HhAntag691; 0 / Pyridines; 0 / Receptors, G-Protein-Coupled; 0 / SMO protein, human
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34. Bishop FS, Liu JK, Chin SS, Fults DW: Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report. Neurosurgery; 2008 Jun;62(6):E1378-9; discussion E1379
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  • [Title] Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report.
  • OBJECTIVE: Hemangioblastomas are the most common primary intra-axial tumors of the adult posterior fossa and the tumors most often associated with von Hippel-Lindau disease.
  • Resection of cerebellar hemangioblastomas involves tumor excision and drainage of associated cysts.
  • The cyst wall is considered devoid of tumor cells and is not excised.
  • We present an unusual variant of a hemangioblastoma that showed pathological evidence of a tumor within the cyst wall that correlated with radiographic cyst wall enhancement in a patient with a recurrent hemangioblastoma.
  • CLINICAL PRESENTATION: A 38-year-old woman with von Hippel-Lindau disease presented with a recurrent cerebellar hemangioblastoma despite two previous operations during which the mural nodule was removed but the cyst wall was not.
  • Histopathological examination showed a capillary hemangioblastoma with tumor tissue inside the cyst wall.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Neoplasm Recurrence, Local / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18824960.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Rasmussen A, Nava-Salazar S, Yescas P, Alonso E, Revuelta R, Ortiz I, Canizales-Quinteros S, Tusié-Luna MT, López-López M: Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma. J Neurosurg; 2006 Mar;104(3):389-94
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  • [Title] Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma.
  • OBJECT: Central nervous system (CNS) hemangioblastomas are benign vascular tumors arising either sporadically or as a manifestation of von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome.
  • The authors studied a series of patients with CNS hemangioblastomas and their families to identify germline mutations in the VHL tumor suppressor gene and to establish a predictive testing and screening protocol.
  • All asymptomatic mutation carriers underwent genetic counseling and tumor surveillance.
  • [MeSH-minor] Adolescent. Adult. Cerebellar Neoplasms. Child. Child, Preschool. DNA Mutational Analysis. Female. Genetic Testing. Humans. Male. Mexico. Middle Aged. Pedigree. Prognosis

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  • (PMID = 16572651.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Wong CY, Noujaim D, Fu HF, Huang WS, Cheng CY, Thie J, Dalal I, Chang CY, Nagle C: Time sensitivity: a parameter reflecting tumor metabolic kinetics by variable dual-time F-18 FDG PET imaging. Mol Imaging Biol; 2009 Jul-Aug;11(4):283-90
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  • [Title] Time sensitivity: a parameter reflecting tumor metabolic kinetics by variable dual-time F-18 FDG PET imaging.
  • OBJECTIVES: The aim of this study was to define and investigate the time sensitivity of tumors by variable dual-time fluorodeoxyglucose positron emission tomography (FDG PET).
  • METHODS: Variable dual-time (t) protocol (P) FDG PET-computed tomography (CT) scans from 40 patients with pathologically proven head and neck tumors without brain metastasis were analyzed.
  • The maximum standardized uptake values (SUVs) were measured in the primary tumor (CA1) and the cerebellum (CBL).
  • Patients with cerebellar variations greater than 30% in SUV between E- and D-PET was excluded from the analysis.
  • RESULTS: Two patients from P.I were excluded due to wide cerebellar SUV variations.
  • CONCLUSIONS: The time sensitivity factor reflects another kinetic parameter of tumor metabolism besides SUV when using variable dual-time FDG PET.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Head and Neck Neoplasms / diagnostic imaging. Head and Neck Neoplasms / metabolism. Radiopharmaceuticals / pharmacokinetics. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Algorithms. Blood Glucose. Female. Humans. Linear Models. Male. Middle Aged. Positron-Emission Tomography. Time Factors

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  • (PMID = 19326175.001).
  • [ISSN] 1860-2002
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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37. Araujo AP, Ribeiro ME, Ricci R, Torquato RJ, Toma L, Porcionatto MA: Glial cells modulate heparan sulfate proteoglycan (HSPG) expression by neuronal precursors during early postnatal cerebellar development. Int J Dev Neurosci; 2010 Nov;28(7):611-20
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  • [Title] Glial cells modulate heparan sulfate proteoglycan (HSPG) expression by neuronal precursors during early postnatal cerebellar development.
  • Cerebellum controls motor coordination, balance, eye movement, and has been implicated in memory and addiction.
  • As in other parts of the CNS, correct embryonic and postnatal development of the cerebellum is crucial for adequate performance in the adult.
  • Cellular and molecular defects during cerebellar development can lead to severe phenotypes, such as ataxias and tumors.
  • This work aimed to investigate changes in heparan sulfate proteoglycans expression during cerebellar development that could unveil control mechanisms.
  • Using real time RT-PCR we evaluated the expression of syndecans, glypicans and modifying enzymes by isolated cerebellar granule cell precursors, and studied the influence of soluble glial factors on the expression of those genes.
  • Our data show for the first time that cerebellar granule cell precursors express members of the Runx family and that the expression of those genes can also be controlled by glial factors.
  • [MeSH-major] Cerebellum / cytology. Cerebellum / growth & development. Heparan Sulfate Proteoglycans / metabolism. Neural Stem Cells / physiology. Neuroglia / metabolism. Neurons / metabolism

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  • [Copyright] Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20638466.001).
  • [ISSN] 1873-474X
  • [Journal-full-title] International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
  • [ISO-abbreviation] Int. J. Dev. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Core Binding Factor alpha Subunits; 0 / Culture Media, Conditioned; 0 / Heparan Sulfate Proteoglycans
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38. Schüller U, Koch A, Hartmann W, Garrè ML, Goodyer CG, Cama A, Sörensen N, Wiestler OD, Pietsch T: Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas. Int J Cancer; 2005 Oct 20;117(1):82-9
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  • Recent findings indicate that the chemokine receptor Cxcr4 is essential for normal development of the cerebellar cortex.
  • As medulloblastomas (MBs), the most common malignant brain tumors of childhood, are believed to arise from neuronal cerebellar precursors, we asked whether there is a potential role for Cxcr4 in the pathogenesis of MB.
  • In addition, a significant correlation of high CXCR4 mRNA levels and presence of the neurotrophin receptor p75NTR or expression of ATOH1 and GLI1 suggests that CXCR4 is a reliable marker for tumors derived from the cerebellar external granular layer.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Receptors, CXCR4 / genetics
  • [MeSH-minor] Adolescent. Adult. Amino Acid Substitution. Basic Helix-Loop-Helix Transcription Factors. Child. Child, Preschool. DNA / genetics. DNA Mutational Analysis. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic. Humans. Infant. Middle Aged. Mutation / genetics. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Oncogene Proteins / genetics. Oncogene Proteins / metabolism. Polymorphism, Single-Stranded Conformational. RNA / genetics. RNA, Messenger / analysis. Receptor, Nerve Growth Factor. Receptors, Nerve Growth Factor / genetics. Receptors, Nerve Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Trans-Activators. Transcription Factors / genetics. Transcription Factors / metabolism. Tumor Cells, Cultured

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15880586.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATOH1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / DNA-Binding Proteins; 0 / Gli protein; 0 / Nerve Tissue Proteins; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / Receptor, Nerve Growth Factor; 0 / Receptors, CXCR4; 0 / Receptors, Nerve Growth Factor; 0 / Trans-Activators; 0 / Transcription Factors; 63231-63-0 / RNA; 9007-49-2 / DNA
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39. Kool M, Koster J, Bunt J, Hasselt NE, Lakeman A, van Sluis P, Troost D, Meeteren NS, Caron HN, Cloos J, Mrsić A, Ylstra B, Grajkowska W, Hartmann W, Pietsch T, Ellison D, Clifford SC, Versteeg R: Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One; 2008;3(8):e3088
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  • BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children.
  • Recent data showed that patients with WNT-activated tumors have a favorable prognosis, suggesting that these patients could be treated less intensively, thereby reducing the side-effects.
  • Mutations in beta-catenin were identified in all 9 type A tumors, but not in any other tumor.
  • PTCH1 mutations were exclusively identified in type B tumors.
  • Monosomy of chromosome 6 occurred only in type A tumors, loss of 9q mostly occurred in type B tumors, whereas chromosome 17 aberrations, most common in medulloblastoma, were strongly associated with type C or D tumors.
  • Loss of the inactivated X-chromosome was highly specific for female cases of type C, D and E tumors.
  • Patients below 3 yrs of age had type B, D, or E tumors.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Gene Expression Profiling. Genomics. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA Mutational Analysis. DNA, Neoplasm / genetics. Female. Humans. Male. Nucleic Acid Hybridization. RNA, Neoplasm / genetics. Signal Transduction. Transforming Growth Factor beta / physiology

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  • (PMID = 18769486.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Neoplasm; 0 / Transforming Growth Factor beta
  • [Other-IDs] NLM/ PMC2518524
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40. Jagannathan J, Lonser RR, Smith R, DeVroom HL, Oldfield EH: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg; 2008 Feb;108(2):210-22
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  • [Title] Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease.
  • OBJECT: Despite the frequency of cerebellar hemangioblastomas in von Hippel-Lindau (VHL) disease, their optimum contemporary management has not been defined, and is made complex because of the multiple, progressive, and protean nature of the tumors found in patients with this disorder.
  • To examine modern management and outcomes of cerebellar hemangioblastomas in VHL disease, the authors reviewed findings in patients with this disease who underwent resection of cerebellar hemangioblastomas.
  • METHODS: Consecutive patients with VHL disease who underwent surgery for cerebellar hemangioblastoma(s) at the National Institutes of Health were included.
  • Eighty consecutive patients (44 female and 36 male patients) underwent 126 operations for removal of 164 cerebellar hemangioblastomas (age at surgery 37.8+/-10.3 years, follow-up duration 96.0+/-60.3 months).
  • Tumors associated with symptoms were larger (diameter 1.8+/-1.9 cm; volume 2.8+/-3.4 cm3; p<0.05) and more likely to be associated with peritumoral edema or peritumoral cysts (100% associated with edema and/or cyst; p<0.05) than asymptomatic tumors (diameter 1.1+/-0.9 cm; volume 0.7+/-0.4 cm3; 18%).
  • More tumors were located in the posterior (74%) compared with the anterior (26%) half of the cerebellum (p<0.05).
  • Preoperative hydrocephalus resolved after tumor removal in 33 cases (94%) and did not require cerebrospinal fluid diversion.
  • CONCLUSIONS: Symptoms and signs caused by cerebellar hemangioblastomas in VHL disease are associated with edema and peritumoral cyst formation/propagation and are treated safely and effectively with resection.
  • Cerebrospinal fluid diversion is rarely necessary after complete tumor removal in patients with preoperative hydrocephalus.
  • Cerebellar hemangioblastomas are preferentially distributed in the posterior half of the cerebellum, as they are in the brainstem and spinal cord.
  • Tumor recurrence is avoided by meticulous extracapsular resection.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Ataxia / physiopathology. Brain Edema / physiopathology. Cerebellar Ataxia / physiopathology. Cranial Irradiation. Cysts / physiopathology. Dissection / methods. Electrocoagulation / methods. Female. Follow-Up Studies. Headache / physiopathology. Humans. Hydrocephalus / physiopathology. Male. Microdissection / methods. Postoperative Complications. Radiosurgery. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 18240914.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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41. Iwai Y, Yamanaka K: Gamma knife radiosurgery for other primary intra-axial tumors. Prog Neurol Surg; 2009;22:129-41
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  • [Title] Gamma knife radiosurgery for other primary intra-axial tumors.
  • We report the usefulness of gamma knife radiosurgery for hemangioblastomas, hemangiopericytomas, germ cell tumors and pineal parenchymal tumors, and primary central nervous system lymphoma (PCNSL).
  • In hemangioblastomas, small solid tumors can be treated very effectively.
  • Radiosurgery is a reasonable option to control residual and recurrent germ cell tumors and pineoblastomas.
  • Although the prognosis is poor for PCNSL patients, gamma knife radiosurgery, even with a relatively low tumor margin dose, is an effective treatment for controlling PCNSL.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Hemangiopericytoma / surgery. Neoplasms, Germ Cell and Embryonal / surgery. Pinealoma / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Lymphoma / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis

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  • (PMID = 18948725.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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42. Puget S, Rutka JT: Malignant brain tumors: two steps forward. Clin Neurosurg; 2007;54:4-9
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  • [Title] Malignant brain tumors: two steps forward.
  • [MeSH-major] Brain Neoplasms / surgery. Glioma / surgery. Neurosurgical Procedures / trends
  • [MeSH-minor] Adult. Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / surgery. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Disease Progression. Female. Forecasting. Gene Expression Profiling. Humans. Male. Medulloblastoma / drug therapy. Medulloblastoma / genetics. Medulloblastoma / surgery. Oligodendroglioma / drug therapy. Oligodendroglioma / genetics. Oligodendroglioma / surgery. Oligonucleotide Array Sequence Analysis

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  • (PMID = 18504889.001).
  • [ISSN] 0069-4827
  • [Journal-full-title] Clinical neurosurgery
  • [ISO-abbreviation] Clin Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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43. Kano H, Niranjan A, Mongia S, Kondziolka D, Flickinger JC, Lunsford LD: The role of stereotactic radiosurgery for intracranial hemangioblastomas. Neurosurgery; 2008 Sep;63(3):443-50; discussion 450-1
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  • OBJECTIVE: To evaluate the role of stereotactic radiosurgery (SRS) in the management of recurrent or residual intracranial hemangioblastomas, we assessed tumor control, survival, and complications in 32 consecutive patients.
  • METHODS: We retrospectively reviewed records of 32 consecutive hemangioblastoma patients (74 intracranial tumors) who underwent gamma knife SRS.
  • Nineteen patients had sporadic lesions (22 tumors), and 13 patients had von Hippel-Lindau disease-associated hemangioblastomas (52 tumors).
  • Follow-up imaging studies demonstrated tumor control in 68 tumors (91.9%).
  • Factors associated with an improved progression-free survival included von Hippel-Lindau disease-associated hemangioblastoma, solid tumor, lower tumor volume, and greater marginal dose.
  • CONCLUSION: SRS is an important tool in the management of hemangioblastomas and is associated with a high tumor control rate and a low risk of adverse radiation effects.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Radiosurgery / trends
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate / trends. Young Adult

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  • (PMID = 18812955.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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44. Oba-Shinjo SM, Caballero OL, Jungbluth AA, Rosemberg S, Old LJ, Simpson AJ, Marie SK: Cancer-testis (CT) antigen expression in medulloblastoma. Cancer Immun; 2008;8:7
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  • Medulloblastoma is the most common childhood malignant tumor of the central nervous system.
  • Due to their presence in various cancers and their limited expression in normal tissues, CT antigens are ideal vaccine targets for tumor immunotherapy.
  • The absence of correlation between mRNA and protein expression in medulloblastoma has not been observed in other tumors and further studies addressing the biology of CT antigens are necessary to investigate the present discrepant results.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Cerebellar Neoplasms / immunology. Medulloblastoma / immunology
  • [MeSH-minor] Adult. Cancer Vaccines. Child. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Membrane Proteins / biosynthesis. Membrane Proteins / genetics. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. RNA Processing, Post-Transcriptional / genetics. RNA, Messenger / metabolism. Testis / metabolism. Testis / pathology

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  • (PMID = 18426187.001).
  • [ISSN] 1424-9634
  • [Journal-full-title] Cancer immunity
  • [ISO-abbreviation] Cancer Immun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / Cancer Vaccines; 0 / MAGEA3 protein, human; 0 / MAGEC1 protein, human; 0 / MAGEC2 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2935780
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45. Asthagiri AR, Mehta GU, Zach L, Li X, Butman JA, Camphausen KA, Lonser RR: Prospective evaluation of radiosurgery for hemangioblastomas in von Hippel-Lindau disease. Neuro Oncol; 2010 Jan;12(1):80-6
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  • Twenty VHL patients (10 males and 10 females) underwent SRS treatment of 44 CNS hemangioblastomas (39 cerebellar and 5 brainstem).
  • Mean treated tumor volume was 0.5 +/- 0.7 cm(3) (range: 0.01-3.6 cm(3)).
  • Mean prescription dose was 18.9 Gy (range: 12-24 Gy) at the tumor margin.
  • Univariate analysis did not identify variables associated (P > .05) with worse tumor control at last follow-up.
  • Thirty-three percent of SRS-treated small (<1.0 cm diameter), asymptomatic tumors progressed over a long-term follow-up.
  • These results indicate that SRS should not be used to prophylactically treat asymptomatic tumors and should be reserved for the treatment of tumors that are not surgically resectable.

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  • (PMID = 20150370.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2940550
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46. Karasaki H, Ishizaki A, Yanagawa N, Nakano Y, Sasajima J, Mizukami Y, Tanno S, Tokusashi Y, Miyokawa N, Obara M, Goto J, Kino S, Kono T, Kasai S: [Two cases of pancreatic tumor with von Hippel-Lindau disease]. Nihon Shokakibyo Gakkai Zasshi; 2008 May;105(5):725-31
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  • [Title] [Two cases of pancreatic tumor with von Hippel-Lindau disease].
  • Adrenal pheochromocytoma, spinal hemangioblastoma and pancreatic endocrine tumor were resected.
  • The second case was a 68-year-old woman with past surgical histories included cerebellar and spinal hemangioblastoma.
  • We considered VHL disease from coexistent multiple tumors include pancreatic involvements and finally diagnosed by genetic examination in both cases.
  • [MeSH-major] Cystadenoma, Serous / complications. Cystadenoma, Serous / surgery. Neoplasms, Multiple Primary. Pancreatic Neoplasms / complications. Pancreatic Neoplasms / surgery. von Hippel-Lindau Disease / complications. von Hippel-Lindau Disease / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Molecular Diagnostic Techniques. Pancreatectomy

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  • (PMID = 18460863.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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47. Jain VK, Mehrotra N, Sahu RN, Behari S, Banerji D, Chhabra DK: Surgery of vestibular schwannomas: an institutional experience. Neurol India; 2005 Mar;53(1):41-5; discussion 45
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  • AIMS: To report management results of vestibular schwannomas (VS) treated surgically in our institute, with particular reference to completeness of tumor excision, facial nerve and hearing preservation and complications of surgery.
  • RESULTS: Most patients had large tumors and had no useful hearing (90%), had disabling cerebellar ataxia (88%) and presented with features of raised intra-cranial pressure (45%).
  • Large sized tumors were in 41.3% and giant sized tumors were in 56% cases.
  • Complete tumor excision was carried out in 96.5% and anatomical preservation of facial nerve was achieved in 79.2% cases.
  • CONCLUSIONS: With experience, complete tumor excision with good facial nerve preservation can be achieved in large tumors.
  • Hearing preservation is difficult in bigger tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 15805654.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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48. Li HY, Xu YK, Lin BQ, Yu T: [Magnetic resonance imaging findings of capillary hemangioma in the brain]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 May;29(5):1043-5, 1048
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  • RESULTS: In the 6 patients, the capillary hemangiomas were located in the pons (n=1), bulbus medullae (n=1), bilateral cerebellar hemisphere (n=1), right temporal lobe (n=1) or left frontal lobe (n=1).
  • Three patients had subacute hemorrhage, 2 had cystic degeneration and 1 had solid tumors, all shoeing heterogeneous MRI signals.
  • Contrast-enhanced MR scans revealed marked heterogeneous enhancement with clear boundaries of the tumor parenchyma, where spots and thin strips without enhancement were seen in 5 cases; vascular network was seen in 1 case.
  • [MeSH-major] Brain Neoplasms / diagnosis. Hemangioma, Capillary / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19460739.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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49. Yağmurlu B, Akyürek S, Fitoz S, Demirkazik A: MRI of non-neoplastic cranial complications of malignant disorders. Diagn Interv Radiol; 2008 Jun;14(2):61-8
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  • PURPOSE: To depict the well-known and atypical magnetic resonance imaging (MRI) findings of non-neoplastic central nervous system (CNS) complications of extra- CNS tumors and portray additional information from advanced techniques, such as diffusion and perfusion MRI.
  • MATERIALS AND METHODS: MRI scans of 92 patients were retrospectively evaluated based on the non-neoplastic effects induced by treatment or the remote effects of the tumor itself.
  • Three patients had bilateral radionecrosis of the temporal lobe due to radiotherapy given for the vicinal tumor (nasopharyngeal carcinoma).
  • One patient had encephalitis in the bitemporal region and one patient had cerebellar degeneration, each of whom had a paraneoplastic syndrome.
  • [MeSH-major] Brain / pathology. Central Nervous System Diseases / diagnosis. Central Nervous System Diseases / etiology. Magnetic Resonance Imaging / methods. Neoplasms / complications
  • [MeSH-minor] Adolescent. Adult. Aged. Central Nervous System Neoplasms / complications. Central Nervous System Neoplasms / diagnosis. Central Nervous System Neoplasms / secondary. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18553277.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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50. Alobid I, Gastón F, Morello A, Guilemany JM, Mullol J: Peripheral primitive neuroectodermal tumor of the cerebellopontine angle. Acta Otolaryngol; 2005 Apr;125(4):426-9
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  • [Title] Peripheral primitive neuroectodermal tumor of the cerebellopontine angle.
  • Peripheral primitive neuroectodermal tumors are highly malignant small cell neoplasms.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Ear, Inner / pathology. Ear, Inner / surgery. Female. Follow-Up Studies. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Retreatment

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  • (PMID = 15823816.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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51. Sameshima T, Fukushima T, McElveen JT Jr, Friedman AH: Critical assessment of operative approaches for hearing preservation in small acoustic neuroma surgery: retrosigmoid vs middle fossa approach. Neurosurgery; 2010 Sep;67(3):640-4; discussion 644-5
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  • METHODS: We reviewed 504 consecutive AN resections performed between November 1998 and September 2007 and identified 43 MF and 82 RS approaches for tumors smaller than 1.5 cm during hearing preservation surgery.
  • Individual cases were examined postoperatively with respect to hearing ability, facial nerve activity, operative time, blood loss, and symptoms resulting from retraction of the cerebellar or temporal lobes.
  • No cerebellar dysfunction was noted in the RS group.
  • [MeSH-minor] Adult. Aged. Audiometry / methods. Female. Humans. Male. Middle Aged. Postoperative Complications / epidemiology

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  • (PMID = 20647969.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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52. Dutta D, Vanere P, Gupta T, Munshi A, Jalali R: Factors influencing activities of daily living using FIM-FAM scoring system before starting adjuvant treatment in patients with brain tumors: results from a prospective study. J Neurooncol; 2009 Aug;94(1):103-10
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  • [Title] Factors influencing activities of daily living using FIM-FAM scoring system before starting adjuvant treatment in patients with brain tumors: results from a prospective study.
  • BACKGROUND: Patients with brain tumors have varied degree of functional and psychological impairments because of factors relating to the tumor or to the treatment they receive.
  • MATERIAL AND METHOD: From August 2007 to April 2008, 150 consecutive adult (>18 years) primary brain tumor patients (median age 40 years; male 88, female 62) registered in a general out-patient neuro-oncology clinic were accrued and detailed data were recorded.
  • Seventy percent had malignant tumor (66% high-grade and 34% low-grade; 70% intra-axial).
  • The common sites for tumors included frontal region (30.7%), posterior fossa (12%), and left parietal region (11.3%).
  • Univariate analysis showed total FIM-FAM scores not significantly different with age (< or =35 years vs. >35 years; P = 0.994), sex (male versus female; P = 0.133), and grade of the tumor (high-grade versus low-grade; P = 0.142) but were significantly higher in patients with a Karnofsky performance score (KPS) of > or =70 as compared with <70 (P = 0.001), neurological performance scale (NPS) of 0 or 1 vs. 2 or 3; P = 0.001), disease type (benign versus malignant; P = 0.001), and site of disease (cerebral versus cerebellar; P = 0.024).
  • A trend for correlation between tumor sites with the corresponding function as assesses on the FIM-FAM score was observed.
  • There is strong correlation with age, type of tumor, and site of disease with different functional and cognitive domain impairment.
  • [MeSH-major] Activities of Daily Living / psychology. Brain Neoplasms / psychology. Disability Evaluation. Stress, Psychological / psychology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Analysis of Variance. Female. Humans. Male. Middle Aged. Prospective Studies. Psychometrics. Retrospective Studies. Severity of Illness Index. Young Adult

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  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
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53. Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T: Genetic characterization of adult infratentorial gliomas. J Neurooncol; 2009 Feb;91(3):251-5
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  • [Title] Genetic characterization of adult infratentorial gliomas.
  • Adult infratentorial gliomas are rare and have not been well studied.
  • We therefore conducted genetic analysis of those tumors to see if there was any characteristic that could be relevant in clinical management and understanding of tumorigenesis.
  • Nineteen adult infratentorial gliomas were analyzed for chromosomal aberration by comparative genomic hybridization, and for expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry.
  • The most frequent chromosomal aberration was the gain of 7p, and five of the seven cerebellar or fourth ventricle malignant gliomas had that aberration.
  • However, the gain of 7q, the characteristic abnormality of supratentorial astrocytomas commonly associated with the gaining of 7p, was observed only in 1 of 11 adult infratentorial astrocytic tumors.
  • Our findings might suggest the presence of distinct tumorigenic pathway in adult infratentorial gliomas.
  • [MeSH-major] Brain Neoplasms / genetics. Frontal Lobe / pathology. Glioma / genetics. Receptor, Epidermal Growth Factor / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Chromosome Aberrations. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. Chromosomes, Human, Pair 7 / genetics. Comparative Genomic Hybridization. Female. Humans. Loss of Heterozygosity. Male. Middle Aged. Young Adult

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  • (PMID = 18941867.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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54. Eberhart CG, Chaudhry A, Daniel RW, Khaki L, Shah KV, Gravitt PE: Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus. BMC Cancer; 2005 Feb 17;5:19
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  • We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors.
  • METHODS: p53 protein levels were evaluated semi-quantitatively in 64 medulloblastomas, 3 atypical teratoid rhabdoid tumors (ATRT), and 8 supratentorial primitive neuroectodermal tumors (sPNET) using immunohistochemistry.
  • Log rank analysis of clinical outcome revealed significantly shorter survival in patients with p53 immunopositive embryonal tumors.
  • No JC virus was identified in the embryonal brain tumor samples, while an endogenous human retrovirus (ERV-3) was readily detected.
  • CONCLUSION: Immunoreactivity for p53 protein is more common in anaplastic medulloblastomas, ATRT and sPNET than in non-anaplastic tumors, and is associated with worse clinical outcomes.

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  • (PMID = 15717928.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS043279; United States / NINDS NIH HHS / NS / K08NS43279
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC554768
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55. Castillo O, Kerkebe M, Vitagliano G, Arellano L: [Single-stage laparoscopic adrenalectomy and pancreatic cyst exsicion in a patient with von Hippel-Lindau disease]. Actas Urol Esp; 2007 Mar;31(3):292-4
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  • INTRODUCTION: Von Hippel-Lindau disease is a dominant autosomic hereditary condition, characterized by cerebellar hemangioblastomas, retinal animas and visceral cysts and tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy / methods. Pancreatic Cyst / complications. Pancreatic Cyst / surgery. Pheochromocytoma / complications. Pheochromocytoma / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Humans. Male


56. Choi KD, Kim JS, Kim HJ, Koo JW, Kim JH, Kim CY, Oh CW, Kee HJ: Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor. Neurology; 2007 Sep 4;69(10):1050-9
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  • [Title] Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor.
  • OBJECTIVE: To determine the incidence and characteristics of hyperventilation-induced nystagmus (HIN) in cerebellopontine angle (CPA) tumors and unilateral peripheral vestibulopathy (UPV), and to elucidate differential contribution of hyperventilation to bring out vestibular asymmetry between acute and chronic phases of UPV.
  • METHODS: We recorded horizontal HIN in 33 patients with CPA tumors and 145 with UPV.
  • RESULTS: The incidence of HIN was higher in the CPA tumor than in the UPV group (82 vs 34%, p < 0.01) and was also higher in the acute than in the chronic UPV group (60 vs 21%, p < 0.01).
  • Furthermore, HIN was more commonly ipsilesional (i-HIN) in the CPA tumor than in the UPV group (52 vs 8%, p < 0.01) and more commonly ipsilesional in the acute than in the chronic UPV group (21 vs 1%, p < 0.01).
  • The patients with i-HIN and acoustic neuroma had a tendency to harbor smaller tumors and to have less severe caloric asymmetry.
  • Our study demonstrates that hyperventilation-induced nystagmus (HIN) beating to the side of reduced caloric response, hearing impairment, or abnormal auditory brainstem response responses may be a valuable sign for bedside detection of cerebellopontine angle (CPA) tumors.
  • CPA tumor should be a prime suspicion in patients with acute vertigo and ipsilesional HIN, especially when the vertigo accompanies hearing impairments.
  • [MeSH-major] Cerebellar Neoplasms / physiopathology. Cerebellopontine Angle / physiopathology. Hyperventilation / physiopathology. Nystagmus, Pathologic / physiopathology. Vestibular Neuronitis / physiopathology
  • [MeSH-minor] Adult. Aged. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Humans. Male. Middle Aged


57. Kaylie DM, Warren FM 3rd, Haynes DS, Jackson CG: Neurotologic management of intracranial epidermoid tumors. Laryngoscope; 2005 Jun;115(6):1082-6
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  • [Title] Neurotologic management of intracranial epidermoid tumors.
  • OBJECTIVES: Epidermoid cysts are the most common intracranial embryonal tumor, although they account for only 1% of all intracranial tumors.
  • The average tumor size was 3.9 cm; six originated in the cerebellopontine angle and four in the petrous apex.
  • Six patients had a translabyrinthine approach to the tumor, two with additional transcochlear exposure.
  • Two patients had tumors removed by way of the middle fossa approach and one through the suboccipital approach.
  • Multiple cranial nerves were involved by tumor in all patients, including nerves III through XI.
  • The internal carotid artery was involved by tumor in four patients.
  • Eight patients required intradural access for complete tumor removal.
  • Seven had complete tumor removal.
  • [MeSH-minor] Adolescent. Adult. Cerebellar Diseases / surgery. Cerebellopontine Angle. Female. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Retrospective Studies

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  • (PMID = 15933526.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Schiefer TK, Link MJ: Epidermoids of the cerebellopontine angle: a 20-year experience. Surg Neurol; 2008 Dec;70(6):584-90; discussion 590
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  • The aim of this study was to review our experience with cerebellopontine-angle epidermoid tumors, as well as the current literature, focusing on the correlation between long-term outcome and the extent of surgical removal.
  • METHODS: We performed a retrospective review of 24 patients with epidermoid tumors of the CPA surgically treated at our institution between 1985 and 2005.
  • The rate of recurrence was 23% in tumors considered totally removed and 27% in those near/subtotally removed.
  • [MeSH-major] Cerebellar Diseases / surgery. Cerebellopontine Angle. Cholesteatoma / surgery. Epidermal Cyst / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cohort Studies. Disease-Free Survival. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18423548.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Kanno H, Yamamoto I, Nishikawa R, Matsutani M, Wakabayashi T, Yoshida J, Shitara N, Yamasaki I, Shuin T, Clinical VHL Research Group in Japan: Spinal cord hemangioblastomas in von Hippel-Lindau disease. Spinal Cord; 2009 Jun;47(6):447-52
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  • RESULTS: Among these 48 patients, 46 of them (95.8%) also had a central nervous system (CNS) hemangioblastoma at another site: 42 (87.5%) with cerebellar hemangioblastoma and 11 (22.9%) with brain stem hemangioblastoma.
  • The 48 patients with spinal cord hemangioblastomas collectively had a total of 74 tumors.
  • The tumor was accompanied with a syrinx in 64 and without it in 10 patients.
  • These tumors can be removed in the majority of VHL patients without aggravation.
  • [MeSH-major] Hemangioblastoma / etiology. Hemangioblastoma / surgery. Spinal Cord Neoplasms / etiology. Spinal Cord Neoplasms / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Neurologic Examination. Retrospective Studies. Severity of Illness Index. Treatment Outcome. Young Adult

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  • (PMID = 19030009.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Investigator] Ibayashi Y; Yamaki T; Numagami Y; Jokura E; Kayama Y; Yamada Y; Shiokawa Y; Yamashita J; Hasegawa M; Hatano H; Shinoda J; Sakai N; Taki W; Matsushima S; Murao K; Matsubara T; Takahashi JA; Matsumoto K; Nakajima H; Hashimoto M; Matsumoto S; Ichigizaki K; Murase I; Kashiwabara K; Yamakawa Y; Yamazaki H; Kubo S; Tokuda K; Abiko S; Miyazaki H; Anda T; Shibata S; Miyamoto T; Okawa N; Morimoto S; Inoue M; Miyagami M
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60. Kawashima M, Rhoton AL Jr, Tanriover N, Ulm AJ, Yasuda A, Fujii K: Microsurgical anatomy of cerebral revascularization. Part II: posterior circulation. J Neurosurg; 2005 Jan;102(1):132-47
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  • OBJECT: Revascularization is an important component of treatment for complex aneurysms, skull base tumors, and vertebrobasilar ischemia in the posterior circulation.
  • METHODS: The microsurgical anatomy of cerebral and cerebellar vessels as they relate to revascularization procedure and techniques, including extracranial-to-intracranial bypass grafting, arterial interposition grafting, and side-to-side anastomosis, were examined by performing stepwise dissections in 22 adult cadaveric specimens.
  • Dominant cerebral and cerebellar revascularization procedures in the posterior circulations include superficial temporal artery (STA)-posterior cerebral artery (PCA), STA-superior cerebellar artery (SCA), occipital artery (OA)-anterior inferior cerebellar artery, OA-posterior inferior cerebellar artery (PICA), and PICA-PICA anastomoses.
  • These procedures are effective in relatively small but critical areas including the brainstem and cerebellum.
  • This will help surgeons consider surgical indications for treatment of patients with vertebrobasilar ischemia caused by aneurysms, tumors, or atherosclerotic diseases in the posterior circulation.

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  • (PMID = 15658105.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Oztürk S, Soyluk O, Görçin S, Alişir S, Güven D, Türkmen A, Sever MS: A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report. J Nephrol; 2005 Nov-Dec;18(6):781-2
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  • [Title] A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report.
  • Hemangioblastoma (HB) is especially prevalent in the cerebellum.
  • On cranial magnetic resonance imaging (MRI), a mass lesion in the right cerebellar hemisphere was observed, 3 x 3 x 3 cm in size, which was pushing against the fourth ventricle, and the right cerebellar peduncle.
  • The pathological diagnosis was cerebellar hemangioblastoma.
  • DISCUSSION: HB causes 2% of all intracranial tumors in the general population.
  • The treatment is surgical excision of the tumor, as in this case.
  • CONCLUSION: When cerebellar symptoms occur or a cerebellar mass lesion is detected in an organ recipient, HB should be considered in the differential diagnosis.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Hemangioblastoma / etiology. Kidney Transplantation / adverse effects
  • [MeSH-minor] Adult. Craniotomy. Follow-Up Studies. Humans. Kidney Failure, Chronic / surgery. Magnetic Resonance Imaging. Male

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  • (PMID = 16358240.001).
  • [ISSN] 1121-8428
  • [Journal-full-title] Journal of nephrology
  • [ISO-abbreviation] J. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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62. Joerger M, Koeberle D, Neumann HP, Gillessen S: Von Hippel-Lindau disease--a rare disease important to recognize. Onkologie; 2005 Mar;28(3):159-63
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  • INTRODUCTION: Von Hippel-Lindau disease (VHL) is an autosomal dominant multisystemic cancer syndrome due to a mutation of the VHL tumor suppressor gene on chromosome 3, region p25-26, with an incidence of 1/36,000 in newborns.
  • Patients are at risk of developing cerebellar, spinal and retinal hemangioblastoma, renal cell carcinoma, pheochromocytoma, pancreatic neuroendocrine tumors, pancreatic and renal cysts, and epididymal cystadenoma.
  • The most common causes of death from VHL are metastases from renal cell carcinoma and neurological complications from cerebellar hemangioblastomas.
  • CASE REPORT: A 19-year-old woman was surgically treated for cerebellar hemangioblastoma in 1998 and for renal cell carcinoma of the right side in 2002.
  • CONCLUSION: The multitude of VHL-associated tumors and intra-familial variability in clinical expressivity render early diagnosis of VHL difficult.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Practice Guidelines as Topic. Practice Patterns, Physicians'

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  • (PMID = 15772467.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 33
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63. Recio MV, Gallagher MJ, McLean MJ, Abou-Khalil B: Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center. Epilepsy Res; 2007 Aug;76(1):1-5
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  • [Title] Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center.
  • PURPOSE: The objective of this study was to describe epilepsy localization, clinical features and surgery outcome in patients with epilepsy and cerebellar structural abnormalities.
  • METHODS: We identified 10 patients with cerebellar lesions and epilepsy from our epilepsy database.
  • Patients with only cerebellar atrophy were excluded.
  • We reviewed imaging data for cerebellar structural findings, as well as cerebral abnormalities.
  • RESULTS: Out of 2288 epilepsy patients in the database, 10 had epilepsy and cerebellar structural abnormalities other than atrophy.
  • The most common cerebellar malformations included Dandy-Walker malformation, cerebellar tumors and posterior fossa arachnoid cyst.
  • CONCLUSION: In this small series, epilepsy associated with cerebellar malformations was usually focal, most often with a temporal lobe focus.
  • The cerebellar lesions did not adversely affect surgical success.
  • [MeSH-major] Cerebellum / abnormalities. Epilepsy / pathology. Epilepsy / surgery. Neurosurgery / methods. Treatment Outcome
  • [MeSH-minor] Adult. Databases, Factual / statistics & numerical data. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Referral and Consultation. Temporal Lobe / surgery

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  • (PMID = 17664061.001).
  • [ISSN] 0920-1211
  • [Journal-full-title] Epilepsy research
  • [ISO-abbreviation] Epilepsy Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
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64. Roth J, Nass D, Ram Z: Cerebellar tumor extension as a late event of long-standing, supratentorial low-grade gliomas: case report. Neurosurgery; 2006 Jun;58(6):E1210; discussion E1210
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  • [Title] Cerebellar tumor extension as a late event of long-standing, supratentorial low-grade gliomas: case report.
  • OBJECTIVE AND IMPORTANCE: Nonpilocytic low-grade glial tumors in adults occur mostly in the supratentorial compartment.
  • The occurrence of LGG in the cerebellum in the setting of a previously existing supratentorial glioma is rare.
  • All three patients presented years after their initial diagnosis with a second, nonenhancing lesion in the cerebellum, compatible with the radiological appearance of LGG.
  • Two patients subsequently became symptomatic from these lesions and underwent surgical resection of the cerebellar lesions that were found to have similar pathological features to the original supratentorial tumors.
  • INTERVENTION: Magnetic resonance imaging did not demonstrate tumor continuity between the supratentorial and infratentorial lesions in any of the patients.
  • The third patient has shown no cerebellar symptoms to date and is only followed with periodic magnetic resonance imaging.
  • CONCLUSION: The anatomic/pathological basis of these rare cases may include a primary, multicentric tumor formation, or a secondary tumor infiltration of the cerebrocerebellar pathways, leading to the formation of the cerebellar tumor.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Glioma / diagnosis. Magnetic Resonance Imaging. Neoplasms, Second Primary / diagnosis. Supratentorial Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged

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  • (PMID = 16723871.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. García Martín G, Perez Errazquin F, Chamorro Muñoz M, Romero Acebal M: [Amyotrophic lateral sclerosis and anti-CV2 antibodies. Paraneoplastic association?]. Neurologia; 2007 Jul-Aug;22(6):406-9
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  • The anti-CV2 are a type of onconeuronal antibody, invariably associated to tumor and described in different PNSs as paraneoplastic encephalomyelitis, cerebellar degeneration and peripheral neuropathy.
  • After three years of follow-up and exhaustive search for tumors, with progression of the disease, there is currently no evidence of associated cancer.
  • When ALS exists, we should rule out association to tumor when the presentation is early (< 30 years) or late (> 70 years), when it is associated to other neurological symptoms/signs (sensory symptoms, ataxia, etc.
  • We also have no knowledge of the existence of anti-CV2 antibodies outside of the tumor context, so that we believe that our patient probably has an occult neoplasm.
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17610172.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibodies; 0 / BMPER protein, human; 0 / Carrier Proteins
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66. Nakamura Y, Kanemura Y, Yamada T, Sugita Y, Higaki K, Yamamoto M, Takahashi M, Yamasaki M: D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells. Mod Pathol; 2006 Jul;19(7):974-85
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  • [Title] D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells.
  • It has been used as a marker for lymphatic endothelium as well as mesothelioma and cerebellar hemangioblastoma.
  • In the developing cerebellum, positive D2-40 immunoreactivity was found in the external granular layer particularly of the outer portion and the Purkinje cell layer as well as meninges.
  • Some brain tumors such as anaplastic ependymoma, some medulloblastomas, glioblastoma, pineal germinoma, craniopharyngioma, choroid plexus papilloma, choroid plexus carcinoma, and meningioma showed positive immunoreactivity with D2-40.
  • Therefore, D2-40 antibody is considered a useful marker for research on developing brain and diagnosis of brain tumors, differentiation between choroid plexus carcinoma and metastatic carcinoma.
  • [MeSH-major] Antibodies, Monoclonal. Antigens, Neoplasm / analysis. Brain Neoplasms / immunology. Cerebellum / immunology. Telencephalon / immunology
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Cells, Cultured. Child, Preschool. Fetus / immunology. Gestational Age. Humans. Immunohistochemistry. Infant. Middle Aged. Neurons / cytology. Neurons / immunology. Prosencephalon / cytology. Stem Cells / cytology. Stem Cells / immunology

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  • (PMID = 16648867.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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67. Koch A, Hrychyk A, Hartmann W, Waha A, Mikeska T, Waha A, Schüller U, Sörensen N, Berthold F, Goodyer CG, Wiestler OD, Birchmeier W, Behrens J, Pietsch T: Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. Int J Cancer; 2007 Jul 15;121(2):284-91
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  • Medulloblastomas (MBs) represent the most common malignant brain tumors in children.
  • Most MBs develop sporadically in the cerebellum, but their incidence is highly elevated in patients with familial adenomatous polyposis coli.
  • These patients carry germline mutations in the APC tumor suppressor gene.
  • The pathway is negatively controlled by the tumor suppressor AXIN2 (Conductin), a scaffold protein of this signaling complex.
  • One MB displayed a somatic, tumor-specific 2 bp insertion in exon 5, leading to carboxy-terminal truncation of the AXIN2 protein.
  • This tumor biopsy showed nuclear accumulation of beta-catenin protein, indicating an activation of Wnt signaling.
  • In 2 further MB biopsies, mutations were identified in exon 5 (Glu408Lys) and exon 8 (Ser738Phe) of the AXIN2 gene, which are due to predicted germline mutations and rare polymorphisms. mRNA expression analysis in 22 MBs revealed reduced expression of AXIN2 mRNA compared to 8 fetal cerebellar tissues.
  • [MeSH-minor] Adolescent. Adult. Axin Protein. Base Sequence. Blotting, Western. Cell Line, Tumor. Cerebellum / embryology. Cerebellum / growth & development. Cerebellum / metabolism. Child. Child, Preschool. DNA Methylation. DNA Mutational Analysis. Female. Gene Expression Profiling. Humans. Infant. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / genetics. Signal Transduction / physiology. Wnt1 Protein / genetics. Wnt1 Protein / metabolism

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17373666.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AXIN2 protein, human; 0 / Axin Protein; 0 / Cytoskeletal Proteins; 0 / RNA, Messenger; 0 / TCF Transcription Factors; 0 / Wnt1 Protein
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68. Phi JH, Kim JH, Eun KM, Wang KC, Park KH, Choi SA, Kim YY, Park SH, Cho BK, Kim SK: Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas. J Neurosurg Pediatr; 2010 Jun;5(6):608-14
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  • [Title] Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas.
  • OBJECT: Supratentorial primitive neuroectodermal tumor (PNET) and medulloblastoma are highly malignant embryonal brain tumors.
  • The authors compared the expression of specific genes involved in neuroglial differentiation in supratentorial PNETs and medulloblastomas to define the distinct characters of these tumors.
  • METHODS: The mRNA expression of 8 genes (SOX2, NOTCH1, ID1, ASCL-1, NEUROD1, NEUROG1, NEUROG2, and NRG1) was evaluated in 25 embryonal tumors (12 supratentorial PNETs and 13 medulloblastomas) by quantitative real-time polymerase chain reaction.
  • The expression levels of the transcripts of these genes were compared between the tumor groups.
  • These divergent differentiation patterns may be related to the location and origin of each tumor.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Inhibitor of Differentiation Protein 1 / genetics. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Receptor, Notch1 / genetics. SOXB1 Transcription Factors / genetics. STAT3 Transcription Factor / genetics. Supratentorial Neoplasms / genetics. Up-Regulation / genetics
  • [MeSH-minor] Adolescent. Adult. Cerebellum / pathology. Cerebral Cortex / pathology. Child. Child, Preschool. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. Infant. Infant, Newborn. Male. Neuroglia / pathology. Neurons / pathology. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transcription, Genetic / genetics

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  • (PMID = 20515335.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ID1 protein, human; 0 / Inhibitor of Differentiation Protein 1; 0 / NOTCH1 protein, human; 0 / RNA, Messenger; 0 / Receptor, Notch1; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human
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69. Brandes AA, Franceschi E: Neuro-oncology: Genetic variation in pediatric and adult brain tumors. Nat Rev Neurol; 2010 Dec;6(12):653-4
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  • [Title] Neuro-oncology: Genetic variation in pediatric and adult brain tumors.
  • Two new studies suggest that pediatric medulloblastomas and high-grade gliomas are genetically different from the same tumors in adults.
  • Age-dependent gene expression might affect tumor biology; therefore, therapies for adult medulloblastomas or gliomas might not produce the same clinical outcomes in pediatric patients, and vice versa.
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. Gene Expression Profiling. Glioma / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adult. Child. Genetic Variation. Humans

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  • (PMID = 21131914.001).
  • [ISSN] 1759-4766
  • [Journal-full-title] Nature reviews. Neurology
  • [ISO-abbreviation] Nat Rev Neurol
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] England
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70. Khalil EM: Treatment results of adults and children with medulloblastoma NCI, Cairo University experience. J Egypt Natl Canc Inst; 2008 Jun;20(2):175-86
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  • PATIENTS AND METHODS: Between 1997 and 2004, 67 patients were treated in the National cancer Institute- Cairo University; 51 pediatric patients with a median age of 7 years and 16 adult patients with a median age of 25 years.
  • According to the Chang staging system; 50%-35% , 37.5%-47% and 12.5%-18% had T2, T3 and T4 tumors of adults and pediatric patient's population respectively.
  • All patients underwent primary surgical resection; near total resection in 25% , Subtotal resection in 61% ; with tumor residual < 1.5cm(2) in 49% compared to 51% with > 1.5cm(2) residual tumor and 14% , had biopsy only.
  • The median interval between surgery and RT was 45 days and 38 days for the pediatric and adult groups respectively.
  • The median duration of RT was 54 days and 52 days for pediatric and adult patients respectively.
  • RESULTS: For the pediatric and adult patients, the 5- and 7-year overall and disease-free survival rates were 89% & 78% vs. 84% & 56% and 80% & 68% vs. 79% & 52% respectively.
  • Ninety percent (9/10) of the pediatric relapses were of the high risk group (8 received no chemotherapy) and took place within 2 years; similarly all adult relapses were of the high risk group; three relapses took place after 2 years.
  • For adult patients; only the risk category was a significant prognostic factor with 5-year disease-free survival rate of 100% vs. 40% for low and high risk respectively (p=0.03).
  • CONCLUSION: Survival rates of medulloblastoma pediatric patients were better than the adult ones.
  • Late relapses, lateral tumor location and shorter median follow up were noted in adult patients.
  • Advanced tumor stage, metastases at presentation, limited tumor resection were powerful prognostic factors among the pediatric patients.
  • In addition, high risk category was shown to be a prognostic factor for both pediatric and adult patients.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cerebellar Neoplasms / therapy. Cranial Irradiation. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20029474.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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71. Jea A, Coscarella E, Chintagumpala M, Bhattacharjee M, Whitehead WE, Curry DJ, Luerssen TG: Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. J Neurosurg Pediatr; 2010 Feb;5(2):149-54
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  • [Title] Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report.
  • Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type have been published in the adult and pediatric literature.
  • However, the simultaneous occurrence of multiple primary brain tumors with different cell types is rare.
  • Even more rare is the pediatric presentation of multiple primary brain tumors with different cell types.
  • Brain MR imaging demonstrated a heterogeneously enhancing mixed solid/cystic mass of the left cerebellar hemisphere and a larger, midline, more homogeneously enhancing lesion of the superior vermis.
  • Pathological examination revealed the left cerebellar and superior vermian lesions to be a juvenile pilocytic astrocytoma and a medulloblastoma, respectively.
  • To the best of the authors' knowledge, they describe the first known pediatric case in which a medulloblastoma and a juvenile pilocytic astrocytoma presented as synchronous primary brain tumors.
  • They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cerebellar Neoplasms / pathology. Medulloblastoma / pathology


72. Deb P, Sharma MC, Gaikwad S, Gupta A, Mehta VS, Sarkar C: Cerebellopontine angle paraganglioma - report of a case and review of literature. J Neurooncol; 2005 Aug;74(1):65-9
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  • Majority of the cerebellopontine angle (CPA) tumors are acoustic neuromas, while bulk of the non-acoustic tumors are formed by meningiomas and epidermoid cysts.
  • Primary paraganglioma is a rare tumor in this location, with only two such cases having been reported in the literature, till date.
  • Recently, a case has been described wherein a paraganglioma was apparently arising as a primary lesion in the cerebellar hemisphere.
  • We report another case of an intracranial paraganglioma of the CPA in a 40-year-old female, which did not have any vascular attachment but had focal cerebellar extension.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Paraganglioma / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Microscopy, Electron, Transmission

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  • (PMID = 16078110.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Viana-Pereira M, Almeida I, Sousa S, Mahler-Araújo B, Seruca R, Pimentel J, Reis RM: Analysis of microsatellite instability in medulloblastoma. Neuro Oncol; 2009 Oct;11(5):458-67
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  • Medulloblastoma is the most common malignant brain tumor in children.
  • The presence of microsatellite instability (MSI) in brain tumors, particularly medulloblastomas, has not been properly addressed.
  • Among the 36 tumors, we found four (11%) cases with instability, one with high MSI and three with low MSI.
  • Methylation analysis of MMR genes in cases presenting shifts on the MSI markers revealed mild hypermethylation of MSH6 in 75% of cases, yet MSH6 was expressed in all the tumors.
  • The MSI target genes MBD4 (methyl-CpG binding domain protein 4) and MRE11 (meiotic recombination 11 homolog A) were mutated in two different tumors.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Microsatellite Instability
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. DNA Methylation. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Young Adult


74. Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ: Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol; 2006 Apr 20;24(12):1924-31
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  • Nonetheless, if we are to avoid rejecting effective molecular targeted therapies, we must test these drugs in patients whose tumors harbor mutations in the drug target.
  • We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities.
  • CONCLUSION: Genome-wide expression profiles can partition large tumor cohorts into subgroups that are enriched for specific genetic alterations.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Gene Expression Profiling. Genomics. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Cost-Benefit Analysis. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Infant, Newborn. Male. Patient Selection. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16567768.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 21765; United States / NCI NIH HHS / CA / CA096832
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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75. Huang TW, Cheng PW, Su HC: The influence of unilateral versus bilateral clicks on the vestibular-evoked myogenic potentials. Otol Neurotol; 2006 Feb;27(2):193-6
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  • SUBJECTS: Fourteen healthy volunteers and four patients with unilateral cerebellopontine angle tumors were enrolled in this study.
  • Four patients with unilateral cerebellopontine angle tumors and prolonged latencies of unilateral clicks vestibular-evoked myogenic potentials also showed latency prolongation in bilateral clicks vestibular-evoked myogenic potentials.
  • [MeSH-major] Cerebellar Neoplasms / physiopathology. Cerebellopontine Angle. Evoked Potentials, Auditory / physiology. Neuroma, Acoustic / physiopathology. Vestibule, Labyrinth / physiology
  • [MeSH-minor] Acoustic Stimulation. Adult. Aged. Case-Control Studies. Electromyography / methods. Epidermal Cyst / physiopathology. Female. Humans. Male. Middle Aged. Muscle, Skeletal / physiology. Prospective Studies

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  • (PMID = 16436989.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Inda MM, Castresana JS: RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system. Neuropathology; 2007 Aug;27(4):341-6
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  • [Title] RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system.
  • Although cancer is rare in children, primary brain tumors constitute the most frequent location of solid tumors in childhood.
  • Primitive neuroectodermal tumors (PNET) of the central nervous system can be divided into infratentorial PNET or medulloblastoma (MB), and supratentorial (sPNET) tumors.
  • The RASSF1A (Ras Association Domain Family Protein 1) gene, located at 3p21.3, is highly methylated in multiple primary tumor samples, including neuroblastoma.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Promoter Regions, Genetic. Supratentorial Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. DNA Methylation. Female. Humans. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17899687.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins
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77. Saito T, Hama S, Kajiwara Y, Sugiyama K, Yamasaki F, Arifin MT, Arita K, Kurisu K: Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas. Anticancer Res; 2006 Mar-Apr;26(2B):1351-7
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  • [Title] Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas.
  • BACKGROUND: Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood.
  • PATIENTS AND METHODS: Clinico-immunohistochemical findings were retrospectively analyzed in 43 supratentorial- and 7 cerebellar GBM.
  • The correlation between survival and immunopositivity for p53, epidermal growth factor receptor (EGFR) and Ki-67 in these tumors was statistically analyzed and compared.
  • All 5 cerebellar GBM patients treated with radio- and chemotherapy were EGFR-immunonegative; they survived significantly longer than patients with supratentorial GBM (p=0.0296) possibly because their EGFR negativity rendered their tumors more highly radiosensitive.
  • CONCLUSION: The better prognosis of patients with cerebellar, EGFR-negative tumors compared to patients with supratentorial tumors is due to the higher radiosensitivity of these tumors.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Glioblastoma / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Supratentorial Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Child. Female. Humans. Immunohistochemistry. Male. Nitrosourea Compounds / administration & dosage. Prognosis. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome

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  • (PMID = 16619544.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Nitrosourea Compounds; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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78. Ganigi PM, Santosh V, Anandh B, Chandramouli BA, Sastry Kolluri VR: Expression of p53, EGFR, pRb and bcl-2 proteins in pediatric glioblastoma multiforme: a study of 54 patients. Pediatr Neurosurg; 2005 Nov-Dec;41(6):292-9
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  • Pediatric glioblastoma multiforme (GBM) tumors, which have been established as 'de novo' neoplasms, are known to differ from their adult counterparts in terms of biology, genetics and ultimately survival of patients.
  • In order to evaluate the utility of markers of tumor biology for refining prognostic assessment, we retrospectively analyzed 54 pediatric GBMs (age range 9 months to 15 years) occurring at different anatomical sites in the brain, operated at our institute between 1995 and 2001.
  • The expression of p53, epidermal growth factor receptor (EGFR), bcl-2 and retinoblastoma proteins (pRb) was analyzed by immunohistochemistry and the results were compared with the clinical profile, MIB-1 labeling index (LI) and patient survival. p53 immunoreactivity was noted in 53.7% of cases, predominantly in thalamic (75%) and cerebral lobar (62.2%), followed by brainstem tumors (30%).
  • It was absent in cerebellar tumors. p53-positive tumors had a higher MIB-1 LI, compared to p53-negative tumors (p=0.003).
  • Our results indicate that p53 expression status is noted in a significant number of pediatric supratentorial neoplasms. p53 with bcl-2 overexpression is more often associated with ominous prognosis.
  • Further molecular characterization would provide newer insights into the biology of these neoplasms and form a basis for future therapeutic decision making.
  • [MeSH-major] Brain Neoplasms / metabolism. Glioblastoma / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Receptor, Epidermal Growth Factor / metabolism. Retinoblastoma Protein / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adolescent. Antibodies, Antinuclear / analysis. Antibodies, Monoclonal / analysis. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Ki-67 Antigen / immunology. Male. Neoplasm Recurrence, Local / metabolism. Prognosis. Retrospective Studies


79. Lai R: Survival of patients with adult medulloblastoma: a population-based study. Cancer; 2008 Apr 1;112(7):1568-74
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  • [Title] Survival of patients with adult medulloblastoma: a population-based study.
  • BACKGROUND: Adult medulloblastoma accounts for less than 1% of adult intracranial tumors.
  • RESULTS: Four hundred fifty-four patients with adult medulloblastoma were diagnosed from 1973-2004 in the 17 regions covered by SEER.
  • [MeSH-major] Cerebellar Neoplasms / mortality. Medulloblastoma / mortality
  • [MeSH-minor] Adult. Cohort Studies. Female. Follow-Up Studies. Humans. Male. Prognosis. Registries. SEER Program. Survival Rate

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  • (PMID = 18278809.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Sai Kiran NA, Kasliwal MK, Suri A, Sharma BS, Suri V, Mridha AR, Sharma MC, Garg A: Eumycetoma presenting as a cerebellopontine angle mass lesion. Clin Neurol Neurosurg; 2007 Jul;109(6):516-9
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  • The prognosis of this bizarre pathology is dismal despite all treatment modalities as compared to the usual tumors of the cerebellopontine angle that generally have a favorable outcome.
  • [MeSH-major] Cerebellar Diseases / diagnosis. Cerebellopontine Angle. Mycetoma / diagnosis. Scedosporium
  • [MeSH-minor] Adult. Amphotericin B / administration & dosage. Antifungal Agents / administration & dosage. Brain Edema / diagnosis. Brain Stem. Decompression, Surgical. Drug Therapy, Combination. Female. Humans. Hydrocephalus / diagnosis. Hydrocephalus / surgery. Ketoconazole / administration & dosage. Magnetic Resonance Imaging. Otitis Media with Effusion / complications. Otitis Media with Effusion / diagnosis. Tomography, X-Ray Computed. Ventriculoperitoneal Shunt

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  • (PMID = 17449170.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antifungal Agents; 7XU7A7DROE / Amphotericin B; R9400W927I / Ketoconazole
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81. Piedimonte LR, Wailes IK, Weiner HL: Medulloblastoma: mouse models and novel targeted therapies based on the Sonic hedgehog pathway. Neurosurg Focus; 2005 Nov;19(5):E8
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  • In children, tumors of the central nervous system are thought to arise from progenitor cells that show considerable temporal and spatial heterogeneity in a developmental environment that is different from that of the adult.
  • Investigating the molecular basis of pediatric tumors is critical because it is likely to generate novel treatments.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Disease Models, Animal. Gene Targeting / methods. Medulloblastoma / genetics. Trans-Activators / genetics

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  • (PMID = 16398472.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA093450
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Shh protein, mouse; 0 / Trans-Activators
  • [Number-of-references] 64
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82. Germanwala AV, Mai JC, Tomycz ND, Niranjan A, Flickinger JC, Kondziolka D, Lunsford LD: Boost Gamma Knife surgery during multimodality management of adult medulloblastoma. J Neurosurg; 2008 Feb;108(2):204-9
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  • [Title] Boost Gamma Knife surgery during multimodality management of adult medulloblastoma.
  • OBJECT: The aim of this paper was to determine prognostic factors for adult medulloblastoma treated with boost Gamma Knife surgery (GKS) following resection and craniospinal irradiation.
  • METHODS: The authors performed a retrospective analysis of 12 adult patients with histologically proven medulloblastoma or supratentorial primitive neuroectodermal tumor who between February 1991 and December 2004 underwent >or=1 sessions of GKS for posttreatment residual or recurrent tumors (6 tumors in each group).
  • Stereotactic radiosurgery was applied to residual and recurrent posterior fossa tumor as well as to foci of intracranial medulloblastoma metastases.
  • The mean GKS-treated tumor volume was 9.4 cm3 (range 0.5-39 cm3).
  • RESULTS: Following adjunctive radiosurgery, 5 patients had no evidence of tumor on magnetic resonance (MR) imaging, 3 patients had stable tumor burden on MR imaging, and 4 patients had evidence of tumor progression locally with or without intracranial metastases.
  • All patients with tumor progression died.
  • The majority of patients who achieved tumor eradication (80%) and tumor stabilization (67%) after GKS had residual tumor as the reason for their referral for GKS.
  • The best outcomes were attained in patients with residual disease who were younger, had smaller tumor volumes, had no evidence of metastatic disease, and had received higher cumulative GKS doses.
  • CONCLUSIONS: Single or multiple GKS sessions were a well-tolerated, feasible, and effective adjunctive treatment for posterior fossa residual or recurrent medulloblastoma as well as intracranial metastatic medulloblastoma in adult patients.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Medulloblastoma / surgery. Neoadjuvant Therapy. Radiosurgery / methods
  • [MeSH-minor] Adult. Age Factors. Chemotherapy, Adjuvant. Cranial Irradiation. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual. Neuroectodermal Tumors / radiotherapy. Neuroectodermal Tumors / surgery. Remission Induction. Retrospective Studies. Spine / radiation effects. Supratentorial Neoplasms / radiotherapy. Supratentorial Neoplasms / surgery. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 18240913.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. DeAngelis LM: Chemotherapy for brain tumors--a new beginning. N Engl J Med; 2005 Mar 10;352(10):1036-8
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  • [Title] Chemotherapy for brain tumors--a new beginning.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Glioblastoma / drug therapy. Medulloblastoma / drug therapy. O(6)-Methylguanine-DNA Methyltransferase / genetics
  • [MeSH-minor] Adult. Cerebellar Neoplasms / drug therapy. Chemotherapy, Adjuvant. Child, Preschool. Gene Silencing. Humans. Survival Analysis

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  • [CommentIn] N Engl J Med. 2005 Jun 2;352(22):2350-3; author reply 2350-3 [15938011.001]
  • [CommentOn] N Engl J Med. 2005 Mar 10;352(10):978-86 [15758008.001]
  • [CommentOn] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009.001]
  • [CommentOn] N Engl J Med. 2005 Mar 10;352(10):997-1003 [15758010.001]
  • (PMID = 15758016.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
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84. Aquilina K, O'Brien DF, Farrell MA, Bolger C: Primary cerebellopontine angle craniopharyngioma in a patient with gardner syndrome. Case report and review of the literature. J Neurosurg; 2006 Aug;105(2):330-3
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  • Although familial adenomatous polyposis (FAP) is associated with intracranial neoplasms, the current case is only the third reported craniopharyngioma in a patient with Gardner syndrome.
  • Two of these tumors, including that of the current case, originated in the CPA, an unusual location for craniopharyngiomas.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Craniopharyngioma / surgery. Gardner Syndrome / surgery
  • [MeSH-minor] Adult. Cerebellum / pathology. Cerebellum / surgery. Diagnosis, Differential. Fibroma / diagnosis. Fibroma / genetics. Fibroma / pathology. Fibroma / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / genetics. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Scalp / pathology. Scalp / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 17219843.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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85. Silvani A: [Experience with the intrathecal use of liposomal cytarabine at the Besta Institute]. Tumori; 2007 May-Jun;93(3):suppl 6-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Astrocytoma / complications. Astrocytoma / drug therapy. Brain Neoplasms / pathology. Breast Neoplasms / pathology. Carcinoma, Non-Small-Cell Lung / complications. Carcinoma, Non-Small-Cell Lung / drug therapy. Cerebellar Neoplasms / pathology. Drug Evaluation. Female. Headache / chemically induced. Humans. Injections, Spinal. Liposomes. Lung Neoplasms / pathology. Male. Neuroectodermal Tumors, Primitive / complications. Neuroectodermal Tumors, Primitive / drug therapy. Palliative Care. Prospective Studies. Retrospective Studies. Treatment Outcome

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  • (PMID = 17679480.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] ita
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Liposomes; 04079A1RDZ / Cytarabine
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86. Sugita Y, Nakamura Y, Yamamoto M, Ogasawara S, Ohshima K, Shigemori M: Expression of KIAA 0864 protein in neuroepithelial tumors: an analysis based on the presence of monoclonal antibody HFB-16. J Neurooncol; 2008 Sep;89(2):151-8
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  • [Title] Expression of KIAA 0864 protein in neuroepithelial tumors: an analysis based on the presence of monoclonal antibody HFB-16.
  • To elucidate the correlation between the KA protein and neuroepithelial tumors (NETs), the present study assessed the KA expression by the NETs using immunohistochemical and Western blot analyses with HFB-16 monoclonal antibody.
  • Among the 55 NETs, a moderate-to-intense KA protein immunoreactivity was observed in 8 of 8 medulloblastomas, 1 of 1 central nervous system supratentorial primitive neuroectodermal tumor (CNS supratentorial PNET), 4 of 4 retinoblastomas, 1 of 1 neuroblastoma, 8 of 8 central neurocytomas, 4 of 4 oligodendrogliomas, 4 of 4 oligoastrocytomas, 1 of 1 extraventricular neurocytoma, and 1 of 1 gangliocytoma.
  • These results indicate that the antibody HFB-16 could be a useful marker for neuronal tumors and primitive neuroectodermal tumors that may originate from immature neural progenitor cells.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Guanine Nucleotide Exchange Factors / metabolism. Medulloblastoma / metabolism. Neoplasms, Neuroepithelial / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18458818.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Guanine Nucleotide Exchange Factors; 0 / RASGRP3 protein, human
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87. Neder L, Scheithauer BW, Turel KE, Arnesen MA, Ketterling RP, Jin L, Moynihan TJ, Giannini C, Meyer FB: Desmoplastic small round cell tumor of the central nervous system: report of two cases and review of the literature. Virchows Arch; 2009 Apr;454(4):431-9
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  • [Title] Desmoplastic small round cell tumor of the central nervous system: report of two cases and review of the literature.
  • Desmoplastic small round cell tumor (DSRCT) is a malignant tumor often involving the abdominal and/or pelvic peritoneum.
  • Patient 2, a 39-year-old man, presented with cerebellar and CPA lesions as well as spinal leptomeningeal deposits.
  • Although rare, DSRCT warrants consideration in the differential diagnosis of "malignant small blue cell tumors" of the CNS.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology
  • [MeSH-minor] Adult. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Magnetic Resonance Imaging. Male. Oncogene Proteins, Fusion / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19263077.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / EWS1-WT1 fusion protein, human; 0 / Oncogene Proteins, Fusion
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88. Jahn K: [Vertigo in children. Clinical presentation, course and treatment]. Nervenarzt; 2009 Aug;80(8):900-8
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  • Because of the relatively high frequency of brainstem and cerebellar tumors in children, MRI should be considered in all patients presenting with subacute central vestibular signs.
  • In principle, all forms of vertigo known in adult patients can also occur in children; however, they must gradually be included in the diagnostic spectrum of the primary care physician (e.g., vestibular paroxysm).

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  • (PMID = 19590845.001).
  • [ISSN] 1433-0407
  • [Journal-full-title] Der Nervenarzt
  • [ISO-abbreviation] Nervenarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 37
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89. Zada G, Day JD, Giannotta SL: The extradural temporopolar approach: a review of indications and operative technique. Neurosurg Focus; 2008;25(6):E3
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  • The main indications for surgery were as follows: meningioma (25 patients, 38%), basilar artery aneurysm (11 patients, 17%), trigeminal schwannoma (7 patients, 11%), chordoma (5 patients, 7%), hemangioma (3 patients, 5%), pituitary adenoma (3 patients, 5%), superior cerebellar artery aneurysm (3 patients, 5%), and other lesions (9 patients, 14%).
  • This is an advantageous approach to large tumors in these regions and for complex upper basilar artery or superior cerebellar artery aneurysms.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brain Neoplasms / radiography. Brain Neoplasms / surgery. Cavernous Sinus / radiography. Cavernous Sinus / surgery. Humans. Middle Aged. Retrospective Studies. Temporal Bone / radiography. Temporal Bone / surgery. Young Adult

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  • (PMID = 19035701.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Bonner MJ, Hardy KK, Willard VW, Anthony KK, Hood M, Gururangan S: Social functioning and facial expression recognition in survivors of pediatric brain tumors. J Pediatr Psychol; 2008 Nov-Dec;33(10):1142-52
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  • [Title] Social functioning and facial expression recognition in survivors of pediatric brain tumors.
  • OBJECTIVE: To assess social functioning and facial expression recognition skill in survivors of pediatric brain tumors (BT) as compared to children with juvenile rheumatoid arthritis (JRA).
  • RESULTS: After controlling for estimated IQ, survivors of BT made significantly more errors interpreting adult facial expressions as compared to children with JRA.
  • [MeSH-major] Brain Damage, Chronic / psychology. Brain Neoplasms / psychology. Cognition Disorders / psychology. Emotions. Facial Expression. Pattern Recognition, Visual. Socialization. Survivors / psychology
  • [MeSH-minor] Adolescent. Arthritis, Juvenile / psychology. Astrocytoma / psychology. Cerebellar Neoplasms / psychology. Child. Ependymoma / psychology. Female. Humans. Intelligence. Male. Medulloblastoma / psychology. Personal Construct Theory. Social Behavior Disorders / diagnosis. Social Behavior Disorders / psychology

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  • (PMID = 18390896.001).
  • [ISSN] 1465-735X
  • [Journal-full-title] Journal of pediatric psychology
  • [ISO-abbreviation] J Pediatr Psychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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91. Nordfors K, Haapasalo J, Korja M, Niemelä A, Laine J, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S, Haapasalo H: The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis. BMC Cancer; 2010;10:148
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Carbonic Anhydrase II / analysis. Carbonic Anhydrases / analysis. Cerebellar Neoplasms / enzymology. Medulloblastoma / enzymology. Neuroectodermal Tumors, Primitive / enzymology. Supratentorial Neoplasms / enzymology
  • [MeSH-minor] Adolescent. Adult. Aged. Apoptosis. Chi-Square Distribution. Child. Child, Preschool. Cytoplasm / enzymology. Endothelial Cells / enzymology. Female. Finland. Humans. Immunohistochemistry. Infant. Infant, Newborn. Kaplan-Meier Estimate. Male. Middle Aged. Odds Ratio. Proportional Hazards Models. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20398423.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; EC 4.2.1.1 / carbonic anhydrase XII
  • [Other-IDs] NLM/ PMC2874782
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92. Liang C, Du Y, Lin X, Wu L, Wu D, Wang X: Anatomical features of the cisternal segment of the oculomotor nerve: neurovascular relationships and abnormal compression on magnetic resonance imaging. J Neurosurg; 2009 Dec;111(6):1193-200
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  • OBJECT: The object of this study was to assess the detailed anatomical features and vascular relationships of the cisternal segment of the oculomotor nerve, and to assess the utility of MR imaging in oculomotor nerve palsy caused by abnormal compression related to arteries and tumors.
  • The images were assessed with respect to the demonstration of the oculomotor nerve, the optimal display angles on MPR images, the visualized length of the nerve, neurovascular relationships, and abnormal compression caused by arteries and tumors.
  • The posterior cerebral artery was observed to contact the oculomotor nerve in 216 (55.1%) of 392 nerves, and the superior cerebellar artery was observed to contact the oculomotor nerve in 231 (58.9%) of 392 nerves.
  • CONCLUSIONS: Use of 3D CISS sequences and 3D time-of-flight sequences enables accurate identification of the cisternal segment of the oculomotor nerve, neurovascular relationships, and abnormal compression caused by arteries and tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aging / pathology. Child. Cholesteatoma / complications. Cholesteatoma / pathology. Female. Humans. Image Processing, Computer-Assisted. Imaging, Three-Dimensional / methods. Magnetic Resonance Imaging / methods. Male. Middle Aged. Young Adult

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  • (PMID = 19267538.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Lagares A, Rivas JJ, Jiménez L, Cicuendez M, Avendaño C: Central demyelination in the pathogenesis of trigeminal neuralgia associated with cerebellopontine angle tumors: case report with ultrastructural trigeminal root analysis. Neurosurgery; 2010 Apr;66(4):E841-2
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  • [Title] Central demyelination in the pathogenesis of trigeminal neuralgia associated with cerebellopontine angle tumors: case report with ultrastructural trigeminal root analysis.
  • OBJECTIVE: To describe the surgical and ultrastructural findings in the trigeminal root of a patient with trigeminal neuralgia (TN) associated with a cerebellopontine epidermoid tumor, and to relate these to literature reports of patients with vascular compression-related TN.
  • Cranial magnetic resonance imaging revealed an epidermoid tumor in the right cerebellopontine angle that distorted and compressed the right trigeminal root.
  • TECHNIQUE: The tumor was resected.
  • At operation, the trigeminal root appeared distorted and compressed by the tumor.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / ultrastructure. Demyelinating Diseases / etiology. Trigeminal Neuralgia / complications
  • [MeSH-minor] Adult. Analgesics, Non-Narcotic / therapeutic use. Carbamazepine / therapeutic use. Female. Humans. Neurosurgery / methods. Rhizotomy / methods

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  • (PMID = 20190659.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Non-Narcotic; 33CM23913M / Carbamazepine
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94. Tang BN, Sadeghi N, Branle F, De Witte O, Wikler D, Goldman S: Semi-quantification of methionine uptake and flair signal for the evaluation of chemotherapy in low-grade oligodendroglioma. J Neurooncol; 2005 Jan;71(2):161-8
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  • Among these tumors, a high percentage of low-grade oligodendrogliomas (ODG) are sensitive to chemotherapy with procarbazine, CCNU, and vincristine (PCV). We aimed at:.
  • Regions of interest (ROI) were generated by covering all voxels with count values above a threshold level set at 120% of the mean cerebellar activity.
  • AVI was calculated as the sum over all ROI of tumor volumex(tumor mean count/cerebellum count).
  • Tumor volume measurements on MRI, were based on signal abnormalities visually detected on fluid-attenuated inversion recovery (FLAIR) sequences.
  • Likewise, we observed a decrease in tumor volume estimated from the FLAIR signal (31.37+/-11.99 post-PCV vs. 67.95+/-39.96 prior PCV, P=0.03) although AVI decrease after PCV was significantly more pronounced (P=0.015).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Lomustine / therapeutic use. Magnetic Resonance Imaging. Methionine / pharmacokinetics. Oligodendroglioma / drug therapy. Positron-Emission Tomography. Procarbazine / therapeutic use. Vincristine / therapeutic use
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15690133.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine; AE28F7PNPL / Methionine; PCV protocol
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95. Daszkiewicz P, Maryniak A, Roszkowski M, Barszcz S: Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. Childs Nerv Syst; 2009 Jul;25(7):855-60
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  • [Title] Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children.
  • PURPOSE: Increasing incidence of pediatric brain tumors and improving survival rates encouraged us to assess long-term functional outcome of patients with cerebellar juvenile pilocytic astrocytoma (JPA).
  • CONCLUSIONS: Long-term functional treatment outcome of cerebellar JPA is relatively favorable, in spite of permanent neurological deficits and emotional disorders in over half of the patients.
  • Vermian tumors are associated with worse long-term functional outcome.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Cerebellum / surgery. Child. Child, Preschool. Education. Female. Follow-Up Studies. Humans. Infant. Male. Mood Disorders / etiology. Nervous System Diseases / etiology. Parents / psychology. Patient Satisfaction. Surveys and Questionnaires. Survival. Treatment Outcome. Young Adult

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  • (PMID = 19418058.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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96. Jamróz B, Niemczyk K, Morawski K, Bartoszewicz R: [Extended middle fossa approach in treatment of vestibular schwannoma--technique of surgery and postoperative complications]. Otolaryngol Pol; 2010 Jun;64(7):3-9
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  • INTRODUCTION: The main tumor of cerebellopontine angle are vestibular schwannoma (80-90%).
  • MATERIAL AND METHODS: 39 patients (40 tumor) suffered from tumor of cerebellopontine angle, operated by using middle fossa approach in years 1998-2007.
  • CONCLUSION: According to NIH middle fossa approach is one of three possible approaches in microsurgery of cerebellopontine angle tumors.
  • There is possible total tumor removal with hearing preservation.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cranial Fossa, Middle / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology
  • [MeSH-minor] Adult. Aged. Audiometry, Pure-Tone. Cerebellopontine Angle / pathology. Female. Hearing Loss / etiology. Hearing Loss / prevention & control. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Poland / epidemiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 21171303.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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97. Misaki K, Marukawa K, Hayashi Y, Fukusato T, Minamoto T, Hasegawa M, Yamashita J, Fujisawa H: Correlation of gamma-catenin expression with good prognosis in medulloblastomas. J Neurosurg; 2005 Mar;102(2 Suppl):197-206
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  • OBJECT: Medulloblastoma is a malignant cerebellar tumor of childhood and is difficult to cure due to frequent cerebrospinal fluid dissemination.
  • Molecules on the Wnt signal pathway in primary tumors were examined.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cytoskeletal Proteins / genetics. Genes, myc / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Antibodies, Neoplasm / immunology. Blotting, Western. Child. Child, Preschool. Combined Modality Therapy. DNA Mutational Analysis. DNA Primers / genetics. Desmoplakins. Genes, bcl-1 / immunology. Humans. Immunohistochemistry. Infant. Point Mutation / genetics. Polymerase Chain Reaction. Prognosis. RNA, Messenger / genetics. Trans-Activators / genetics. Trans-Activators / immunology. beta Catenin. gamma Catenin

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  • (PMID = 16156230.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / DNA Primers; 0 / Desmoplakins; 0 / JUP protein, human; 0 / RNA, Messenger; 0 / Trans-Activators; 0 / beta Catenin; 0 / gamma Catenin
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98. Riffaud L, Saikali S, Leray E, Hamlat A, Haegelen C, Vauleon E, Lesimple T: Survival and prognostic factors in a series of adults with medulloblastomas. J Neurosurg; 2009 Sep;111(3):478-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: In this article, the authors report their experience in the management of adult patients with medulloblastoma at their institution to identify prognostic factors important for survival and disease control.
  • Staging according to the Chang classification showed 4 patients with tumors invading the brainstem (2 with Stage T3b and 2 with Stage T4), 3 patients with metastases (2 with Stage M2 and 1 with Stage M3), and 1 patient in whom the stage was unknown (Stage MX) who died 10 days postoperatively.
  • Patient age, duration of symptoms, Karnofsky Performance Scale score at presentation, hydrocephalus, tumor location, brainstem invasion, extent of resection, histological subtype, preradiotherapy chemotherapy, risk group, and period of presentation were not significant variables.
  • Eleven patients suffered tumor recurrence within a median time of 4.2 years.
  • All patients in whom the tumor recurred have died despite aggressive treatments.
  • Tumor recurrences should be treated with aggressive therapies as some patients may have sustained response.
  • [MeSH-major] Cerebellar Neoplasms / mortality. Medulloblastoma / mortality
  • [MeSH-minor] Adolescent. Adult. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Quality of Life. Sex Factors. Survival Rate

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  • (PMID = 19231932.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Lachenal F, Cotton F, Desmurs-Clavel H, Haroche J, Taillia H, Magy N, Hamidou M, Salvatierra J, Piette JC, Vital-Durand D, Rousset H: Neurological manifestations and neuroradiological presentation of Erdheim-Chester disease: report of 6 cases and systematic review of the literature. J Neurol; 2006 Oct;253(10):1267-77
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  • Cerebellar and pyramidal syndromes were the most frequent clinical manifestations (41% and 45% of cases), but seizures, headaches, neuropsychiatric or cognitive troubles, sensory disturbances, cranial nerve paralysis or asymptomatic lesions were also reported.
  • Neuroradiological findings could be separated into three patterns: the infiltrative pattern (44%), with widespread lesions, nodules or intracerebral masses, the meningeal pattern (37%), with either thickening of the dura mater or meningioma-like tumors, and the composite pattern (19%), with both infiltrative and meningeal lesions.
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiography. Seizures / etiology

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  • (PMID = 17063320.001).
  • [ISSN] 0340-5354
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 58
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100. Yoshida S, Takahashi H: Cerebellar metastases in patients with cancer. Surg Neurol; 2009 Feb;71(2):184-7; discussion 187
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  • [Title] Cerebellar metastases in patients with cancer.
  • BACKGROUND: Cerebellar metastases are considered a negative prognostic factor in patients with systemic cancers.
  • We retrospectively reviewed the treatment and outcome of 109 patients with cerebellar metastases.
  • METHODS: A total of 1240 patients with metastatic brain tumors were identified and treated between January 1990 and December 2005.
  • RESULTS: Cerebellar metastases occurred in 109 (8.7%) of these patients.
  • CONCLUSIONS: Aggressive treatment including surgical resection and radiotherapy for patients and high performance status (KPS of at least 70) are associated with longer survival for selected patients with cerebellar metastases.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / secondary. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Radiosurgery. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18295837.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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