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1. Dwarakanath S, Suri A, Sharma BS, Mehta VS: Intracranial hemangioblastomas: an institutional experience. Neurol India; 2006 Sep;54(3):276-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor was located in the cerebellar hemispheres, vermian and brainstem regions in 42 (60%) patients, 19 (28%) patients and 8 (12%) patients, respectively.
  • Thirty-three patients underwent CSF diversion procedures prior to surgery on the tumor.
  • Sixty eight patients underwent surgery on the tumor.
  • [MeSH-major] Brain Neoplasms. Hemangioblastoma. Institutional Practice / statistics & numerical data
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Male. Retrospective Studies. von Hippel-Lindau Disease / etiology

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  • (PMID = 16936388.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
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2. Tashjian VS, Khanlou N, Vinters HV, Canalis RF, Becker DP: Hemangiopericytoma of the cerebellopontine angle: a case report and review of the literature. Surg Neurol; 2009 Sep;72(3):290-5
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  • BACKGROUND: Intracranial hemangiopericytoma represents a rare intracranial tumor that is typically difficult to distinguish from meningioma based on clinical presentation and radiographic findings.
  • These inherently aggressive neoplasms have been observed to occur in numerous intracranial compartments; however, isolated involvement of the CPA is essentially unreported.
  • CONCLUSION: Given the fundamentally different treatment approach for HPCs over other more common CPA tumors, it is imperative that the treating surgeon consider this rare diagnosis when evaluating patients with lesions localized to this area.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / therapy. Cerebellopontine Angle. Hemangiopericytoma / diagnosis. Hemangiopericytoma / therapy
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Meningioma / diagnosis. Meningioma / surgery. Neoplasm Recurrence, Local / prevention & control. Positron-Emission Tomography. Radiotherapy, Adjuvant

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  • (PMID = 18786704.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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3. Galeeva A, Treuter E, Tomarev S, Pelto-Huikko M: A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain. Neuroscience; 2007 May 11;146(2):604-16
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  • [Title] A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain.
  • However, very little is known about Prox-1 expression and functions in the adult nervous system.
  • Here we have investigated the expression pattern of Prox-1 mRNA and protein during postnatal brain development and in adult rat and mouse brains using in situ hybridization (ISH), immunohistochemistry (IHC) and Western blotting.
  • In the developing and adult brain, we found prominent, but restricted Prox-1 mRNA expression in the dentate gyrus of the hippocampus, in some thalamic nuclei, notably in the anterior thalamus, and in the cerebellar cortex.
  • Using IHC and ISH approaches, we demonstrated rather restricted, but intense Prox-1 labeling in adult brain of both rat and mouse species.
  • The prominent but limited distribution of Prox-1 in the brain suggests its potentially important role during postnatal brain development and in adult CNS, which remains to be ascertained in future studies.
  • [MeSH-major] Brain / growth & development. Brain / metabolism. Gene Expression Regulation, Developmental / physiology. Homeodomain Proteins / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 17368742.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins; 0 / prospero-related homeobox 1 protein
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4. Nigri F, Telles C, Acioly MA: Late obstruction of an endoscopic third ventriculostomy stoma by metastatic seeding of a recurrent medulloblastoma. J Neurosurg Pediatr; 2010 Jun;5(6):641-4
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  • Secondary obstruction of the stoma due to intraventricular tumor seeding is an extremely rare condition, with only one case described to date.
  • In such cases of late failure of the ETV stoma because of tumor obstruction, a second ETV can be safely performed and lead to adequate function of the stoma, even if limited by the aggressive nature of the disease.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Hydrocephalus / pathology. Hydrocephalus / surgery. Medulloblastoma / pathology. Medulloblastoma / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Seeding. Neuroendoscopy. Third Ventricle / pathology. Third Ventricle / surgery. Ventriculostomy
  • [MeSH-minor] Adolescent. Adult. Cerebrospinal Fluid / cytology. Disease Progression. Fatal Outcome. Follow-Up Studies. Fourth Ventricle / pathology. Fourth Ventricle / surgery. Humans. Magnetic Resonance Imaging. Male. Reoperation. Young Adult

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  • (PMID = 20515341.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Pizem J, Cört A, Zadravec-Zaletel L, Popovic M: Survivin is a negative prognostic marker in medulloblastoma. Neuropathol Appl Neurobiol; 2005 Aug;31(4):422-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Cytoskeletal Proteins / metabolism. Female. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Male. Middle Aged. Prognosis. Survival Analysis. Trans-Activators / metabolism. Up-Regulation. beta Catenin

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  • (PMID = 16008826.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Trans-Activators; 0 / beta Catenin
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6. Ganigi PM, Santosh V, Anandh B, Chandramouli BA, Sastry Kolluri VR: Expression of p53, EGFR, pRb and bcl-2 proteins in pediatric glioblastoma multiforme: a study of 54 patients. Pediatr Neurosurg; 2005 Nov-Dec;41(6):292-9
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  • Pediatric glioblastoma multiforme (GBM) tumors, which have been established as 'de novo' neoplasms, are known to differ from their adult counterparts in terms of biology, genetics and ultimately survival of patients.
  • In order to evaluate the utility of markers of tumor biology for refining prognostic assessment, we retrospectively analyzed 54 pediatric GBMs (age range 9 months to 15 years) occurring at different anatomical sites in the brain, operated at our institute between 1995 and 2001.
  • The expression of p53, epidermal growth factor receptor (EGFR), bcl-2 and retinoblastoma proteins (pRb) was analyzed by immunohistochemistry and the results were compared with the clinical profile, MIB-1 labeling index (LI) and patient survival. p53 immunoreactivity was noted in 53.7% of cases, predominantly in thalamic (75%) and cerebral lobar (62.2%), followed by brainstem tumors (30%).
  • It was absent in cerebellar tumors. p53-positive tumors had a higher MIB-1 LI, compared to p53-negative tumors (p=0.003).
  • Our results indicate that p53 expression status is noted in a significant number of pediatric supratentorial neoplasms. p53 with bcl-2 overexpression is more often associated with ominous prognosis.
  • Further molecular characterization would provide newer insights into the biology of these neoplasms and form a basis for future therapeutic decision making.
  • [MeSH-major] Brain Neoplasms / metabolism. Glioblastoma / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Receptor, Epidermal Growth Factor / metabolism. Retinoblastoma Protein / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adolescent. Antibodies, Antinuclear / analysis. Antibodies, Monoclonal / analysis. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Ki-67 Antigen / immunology. Male. Neoplasm Recurrence, Local / metabolism. Prognosis. Retrospective Studies


7. Roser F, Nakamura M, Dormiani M, Matthies C, Vorkapic P, Samii M: Meningiomas of the cerebellopontine angle with extension into the internal auditory canal. J Neurosurg; 2005 Jan;102(1):17-23
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  • The authors investigated cases of CPA tumors in which the meningioma was inserted in the dura mater in or at the ICA or infiltrated a cranial nerve.
  • Total tumor resection was achieved in 86.1%.
  • In 34 patients, opening of the IAC was required for total tumor removal; this procedure did not influence the patient functional outcome.
  • Functional preservation of the seventh and eighth cranial nerves in cases of tumor extension within the IAC was 86 and 77%, respectively, whereas in cases in which the IAC was involved it was only 60%.
  • In four of five patients in whom the tumor had its origin in the dura mater within the IAC, the seventh or eighth cranial nerve had to be sacrificed to achieve tumor removal because of the lesion's infiltrative behavior.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Ear, Inner / pathology. Meningeal Neoplasms / surgery. Meningioma / surgery
  • [MeSH-minor] Adult. Aged. Evoked Potentials, Auditory / physiology. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / physiopathology. Female. Humans. Intraoperative Care. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / radiography. Postoperative Care. Severity of Illness Index. Tomography, X-Ray Computed. Vestibulocochlear Nerve Diseases / diagnosis. Vestibulocochlear Nerve Diseases / epidemiology. Vestibulocochlear Nerve Diseases / physiopathology

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  • (PMID = 15658091.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Fukushima S, Terasaki M, Tajima Y, Shigemori M: Granulocytic sarcoma: an unusual complication of acute promyelocytic leukemia causing cerebellar hemorrhage. Case report. J Neurosurg; 2006 Dec;105(6):912-5
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  • [Title] Granulocytic sarcoma: an unusual complication of acute promyelocytic leukemia causing cerebellar hemorrhage. Case report.
  • Granulocytic sarcomas are rare tumors that occur primarily in patients with acute myelogenous leukemia or other myeloproliferative disorders, are seldom seen in patients with acute promyelocytic leukemia (APL), and have never been reported to occur in the cerebellum.
  • The authors describe the case of a patient with APL who harbored a hemorrhagic granulocytic sarcoma in the cerebellum.
  • This 39-year-old woman presented with cerebellar ataxia.
  • Magnetic resonance images revealed an intraaxial tumor in the cerebellum.
  • Results of histopathological studies and immunohistochemical staining of the cerebellar tumor confirmed a granulocytic sarcoma.
  • This is the first report to document a granulocytic sarcoma in the cerebellum as the primary presentation in a patient with APL and abnormal coagulation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Cerebral Hemorrhage / etiology. Leukemia, Promyelocytic, Acute / complications. Sarcoma, Myeloid / etiology
  • [MeSH-minor] Adult. Bone Marrow / pathology. Cerebellar Ataxia / etiology. Cerebellum / pathology. Chimera / genetics. Female. Gene Fusion / genetics. Granulocyte Precursor Cells / pathology. Humans. Inclusion Bodies / pathology. Karyotyping. Magnetic Resonance Imaging. Receptors, Retinoic Acid / genetics

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  • (PMID = 17405265.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Retinoic Acid; 0 / retinoic acid receptor alpha
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9. Tanemura E, Masue T, Sugimoto J, Dohi S: Repetitive acute shock following tracheal extubations after neurosurgery for a cerebellar tumor. J Anesth; 2006;20(3):255-6
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  • [Title] Repetitive acute shock following tracheal extubations after neurosurgery for a cerebellar tumor.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Intubation, Intratracheal / methods. Neurosurgical Procedures / methods. Shock / etiology
  • [MeSH-minor] Acute Disease. Adult. Airway Obstruction / etiology. Airway Obstruction / surgery. Blood Gas Analysis / methods. Blood Pressure. Bulbar Palsy, Progressive / complications. Bulbar Palsy, Progressive / diagnosis. Humans. Hypotension / etiology. Male. Recurrence. Tracheotomy

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  • [Cites] Acta Anaesthesiol Scand. 2000 Apr;44(4):378-82 [10757568.001]
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  • (PMID = 16897254.001).
  • [ISSN] 0913-8668
  • [Journal-full-title] Journal of anesthesia
  • [ISO-abbreviation] J Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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10. Barnes M, Eberhart CG, Collins R, Tihan T: Expression of p75NTR in fetal brain and medulloblastomas: evidence of a precursor cell marker and its persistence in neoplasia. J Neurooncol; 2009 Apr;92(2):193-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis factor superfamily, and plays a significant role in nervous system development. p75NTR has a dual (proliferative/apoptotic) role in neurogenesis and binds pro-neurotrophins with high affinity.
  • Recent work suggests p75NTR is overexpressed in the developing cerebellum and in nodular/desmoplastic medulloblastomas.
  • We analyzed p75NTR expression in various parts of the fetal and adult human central nervous system, and in 75 patients with medulloblastomas.
  • The staining was present in gestational weeks 20-40, while no staining was identified elsewhere in the fetal brain or within the adult cerebellum. p75NTR positive cells were also positive with the proliferation marker ki-67, but were negative for ret, reelin, CD133, CD34, and cleaved caspase 3.
  • The persistence of p75NTR in a small group of medulloblastomas raises the possibility that in such tumors, the receptor could be a potential therapeutic target.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain / metabolism. Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. Receptor, Nerve Growth Factor / biosynthesis

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  • (PMID = 19066726.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptor, Nerve Growth Factor
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11. Comincini S, Chiarelli LR, Zelini P, Del Vecchio I, Azzalin A, Arias A, Ferrara V, Rognoni P, Dipoto A, Nano R, Valentini G, Ferretti L: Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells. Oncol Rep; 2006 Dec;16(6):1325-32
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  • [Title] Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells.
  • It is abundant in testis and, unlike PrP, it is expressed at low levels in the adult central nervous system (CNS).
  • Besides, Dpl overexpression correlates with some prion-disease pathological features, such as ataxia and death of cerebellar neurons.
  • Recently, ectopic expression of doppel was found in two different tumor types, specifically in glial and haematological cancers.
  • Immunohistochemistry experiments demonstrated that Dpl was mainly localised in the cytoplasm of the astrocytic tumor cells, and that it failed to be GPI-anchored to the cell membrane.
  • [MeSH-major] Astrocytoma / metabolism. Brain Neoplasms / metabolism. Cell Nucleus / metabolism. Prions / biosynthesis. RNA, Messenger / metabolism
  • [MeSH-minor] Blotting, Northern. Blotting, Western. Cell Line, Tumor. Cytoplasm / metabolism. GPI-Linked Proteins. Gene Expression. Gene Expression Profiling. Humans. Immunohistochemistry. Protein Biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Transcription, Genetic. Transfection

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  • (PMID = 17089057.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / PRND protein, human; 0 / Prions; 0 / RNA, Messenger
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12. Francesco F, Maurizio I, Stefano C, Marina S, Ugo S, Massimo S: Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor. J Neurooncol; 2010 Apr;97(2):285-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor.
  • Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults.
  • Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors.
  • We describe a pilocytic astrocytoma of the CPA that was found to arise from the proximal portion of trigeminal nerve without any anatomic continuity with the brain stem and the cerebellum.
  • The proposed origin of this extremely rare tumor is the root entry zone of the involved nerve.
  • The tumor was completely resected via a suboccipital retrosigmoid approach.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Cranial Nerve Neoplasms / pathology. Trigeminal Nerve Diseases / pathology
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19820900.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Maussion G, Carayol J, Lepagnol-Bestel AM, Tores F, Loe-Mie Y, Milbreta U, Rousseau F, Fontaine K, Renaud J, Moalic JM, Philippi A, Chedotal A, Gorwood P, Ramoz N, Hager J, Simonneau M: Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. Hum Mol Genet; 2008 Aug 15;17(16):2541-51
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  • We found that MARK1 was overexpressed in the prefrontal cortex (BA46) but not in cerebellar granule cells, on postmortem brain tissues from patients.
  • [MeSH-minor] Adolescent. Adult. Animals. Cell Line, Tumor. Cell Polarity. Cerebellar Cortex / enzymology. Cerebellar Cortex / physiopathology. Child. Child, Preschool. Chromosome Mapping. Chromosomes, Human, Pair 1 / genetics. Dendrites / chemistry. Dendrites / enzymology. Dendrites / physiology. Evolution, Molecular. Female. Gene Expression. Haplotypes. Humans. Male. Mice. Middle Aged. Polymorphism, Single Nucleotide. Protein Transport

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  • (PMID = 18492799.001).
  • [ISSN] 1460-2083
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / MARK1 protein, human; EC 2.7.11.1 / MARK1 protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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14. Liang J, Li G, Li Q, Liu G: [Remov ing the tumor of the cerebellopontile angle with microsurgery to treat the secondary trigeminal neuralgia]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 May;19(10):446-8
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  • [Title] [Remov ing the tumor of the cerebellopontile angle with microsurgery to treat the secondary trigeminal neuralgia].
  • OBJECTIVE: In order to explore the relationship between the tumor of cerebellopontile angle(CPA) and trigeminal neuralgia and to select the surgical treatment.
  • METHOD: With retrosigmoidal approach, the tumors of CPA were removed in 56 patients with the tumor of CPA and coexisting trigeminal neuralgia.
  • RESULT: All tumors were totally removed except one meningcoma which was removed by only 2/3 parts.
  • CONCLUSION: The pressure to the root of trigeminal nerve which comes from the tumor of CPA may be one of the etiologies of trigeminal neuralgia, which could be treated with the removal of the tumor of CPA.
  • The micrurgy of removing the tumor with retrosigmoidal approach is an ideal functional operation.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Microsurgery. Trigeminal Neuralgia / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures. Neurosurgical Procedures / methods

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  • (PMID = 16108320.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Srikantha U, Balasubramaniam A, Santosh V, Somanna S, Bhagavatula ID, Ashwathnarayana CB: Recurrence in medulloblastoma - influence of clinical, histological and immunohistochemical factors. Br J Neurosurg; 2010 Jun;24(3):280-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms. Medulloblastoma. Neoplasm Recurrence, Local
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Female. Humans. Immunohistochemistry. India / epidemiology. Male. Middle Aged. Prognosis. Receptor, ErbB-2 / metabolism. Retrospective Studies. Survival Rate. Tumor Suppressor Protein p53 / metabolism. Young Adult

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  • (PMID = 20465457.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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16. Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ: Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol; 2006 Apr 20;24(12):1924-31
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  • Nonetheless, if we are to avoid rejecting effective molecular targeted therapies, we must test these drugs in patients whose tumors harbor mutations in the drug target.
  • We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities.
  • CONCLUSION: Genome-wide expression profiles can partition large tumor cohorts into subgroups that are enriched for specific genetic alterations.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Gene Expression Profiling. Genomics. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Cost-Benefit Analysis. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Infant, Newborn. Male. Patient Selection. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16567768.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 21765; United States / NCI NIH HHS / CA / CA096832
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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17. Low JA, de Sauvage FJ: Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol; 2010 Dec 20;28(36):5321-6
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  • A number of tumor types rely on overexpression of Hh ligands to activate the pathway in a paracrine manner from the tumor to the surrounding stroma.
  • However, the role of the Hh pathway is best established in tumors, such as basal cell carcinoma and medulloblastoma, where the pathway is activated via mutations.
  • Understanding the contribution of Hh signaling in these various tumor types will be critical to the development and use of agents targeting this pathway in the clinic.
  • [MeSH-major] Anilides / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Basal Cell / drug therapy. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Pyridines / therapeutic use. Skin Neoplasms / drug therapy
  • [MeSH-minor] Adult. Child. Hedgehog Proteins / antagonists & inhibitors. Hedgehog Proteins / physiology. Humans. Paracrine Communication / physiology. Receptors, G-Protein-Coupled / physiology. Signal Transduction

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  • (PMID = 21041712.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anilides; 0 / Antineoplastic Agents; 0 / Hedgehog Proteins; 0 / HhAntag691; 0 / Pyridines; 0 / Receptors, G-Protein-Coupled; 0 / SMO protein, human
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18. Zhang J, Yang C, Gu HH, Liang WM: [Intraoperative cranial nerves monitoring under partial neuromuscular relaxation during cerebellopontine angle tumor resection]. Zhonghua Yi Xue Za Zhi; 2008 Jun 3;88(21):1481-4
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  • [Title] [Intraoperative cranial nerves monitoring under partial neuromuscular relaxation during cerebellopontine angle tumor resection].
  • OBJECTIVE: To evaluate the efficacy of multiple cranial nerves monitoring under partial Seventy elective neuromuscular relaxation during cerebellopontine angle (CPA) tumor resection.
  • METHODS: patients undergoing CPA tumor resection via microneurosurgery were randomly allocated to 2 equal groups: Group FN receiving intraoperative facial nerve (NF) monitoring and Group MN receiving monitoring of multiple nerves: trigeminal nerve, glossopharyngeal nerve, accessory nerve or hypoglossal nerve other than the FN which were considered at risk by the neurosurgeon preoperatively.
  • Multiple cranial nerves combined with facial nerve monitoring seems unable to increase the short-term protective effects of nerve function after CPA tumor resection.
  • [MeSH-major] Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Cranial Nerves / physiopathology
  • [MeSH-minor] Adult. Feasibility Studies. Female. Humans. Male. Middle Aged. Monitoring, Intraoperative. Muscle Relaxation

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  • (PMID = 18953855.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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19. Peyre M, David P, Van Effenterre R, François P, Thys M, Emery E, Redondo A, Decq P, Aghakhani N, Parker F, Tadié M, Lacroix C, Bhangoo R, Giraud S, Richard S, French NCI Network VHL Disease and Inherited Predisposition to Kidney Cancer: Natural history of supratentorial hemangioblastomas in von Hippel-Lindau disease. Neurosurgery; 2010 Sep;67(3):577-87; discussion 587
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  • OBJECTIVE: Following recent advances in our understanding of the natural history of von Hippel-Lindau-associated cerebellar and spinal hemangioblastomas, we conducted a study of the natural history of supratentorial hemangioblastomas in von Hippel-Lindau disease.
  • Only 6 tumors had a cyst at diagnosis or during follow-up, and only 6 patients had associated symptoms at presentation or during follow-up.
  • Of 14 tumors with documented serial imaging, 13 demonstrated tumor growth.
  • Rates and patterns of tumor growth were unique to each patient.
  • CONCLUSION: This series illustrates the wide variation in tumor locations, patterns of growth, and edema progression seen in supratentorial hemangioblastomas and adds to our knowledge of the natural history of hemangioblastomas.
  • [MeSH-minor] Adolescent. Adult. Cohort Studies. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 20647972.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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20. Abel TW, Baker SJ, Fraser MM, Tihan T, Nelson JS, Yachnis AT, Bouffard JP, Mena H, Burger PC, Eberhart CG: Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway. J Neuropathol Exp Neurol; 2005 Apr;64(4):341-9
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  • Lhermitte-Duclos disease (LDD) is a rare cerebellar tumor associated with Cowden disease (CD) and germline mutations in the PTEN gene.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Cerebellar Neoplasms / physiopathology. Ganglioneuroma / metabolism. Ganglioneuroma / physiopathology. Phosphoric Monoester Hydrolases / metabolism. Protein Kinases / metabolism. Protein-Serine-Threonine Kinases / metabolism. Proto-Oncogene Proteins / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Female. Hamartoma Syndrome, Multiple / metabolism. Hamartoma Syndrome, Multiple / physiopathology. Humans. Immunohistochemistry. Male. Middle Aged. PTEN Phosphohydrolase. Proto-Oncogene Proteins c-akt. Signal Transduction / physiology. TOR Serine-Threonine Kinases. Thyroid Diseases / metabolism. Thyroid Diseases / physiopathology

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  • (PMID = 15835270.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K08NS/CA43279; United States / NINDS NIH HHS / NS / NS44172
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / AKT1 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Number-of-references] 32
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21. Akiyama Y, Ikeda J, Ibayashi Y, Nonaka T, Asai Y, Houkin K: Lhermitte-Duclos disease with cervical paraspinal arteriovenous fistula. Neurol Med Chir (Tokyo); 2006 Sep;46(9):446-9
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  • A 38-year-old man presented with a dysplastic cerebellar gangliocytoma associated with a paraspinal arteriovenous fistula (AVF) at the upper cervical portion.
  • The patient was treated by embolization of the AVF followed by partial resection of the cerebellar tumor.
  • Lhermitte-Duclos disease is a rare dysplastic gangliocytoma manifesting as a slowly growing mass in the cerebellum and is usually asymptomatic.
  • [MeSH-major] Arteriovenous Fistula / etiology. Cerebellar Neoplasms / complications. Ganglioneuroma / complications. Jugular Veins / abnormalities. Vertebral Artery / abnormalities
  • [MeSH-minor] Adult. Cervical Vertebrae. Humans. Male. PTEN Phosphohydrolase / genetics

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  • (PMID = 16998279.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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22. Mitsuyama T, Ide M, Hagiwara S, Tanaka N, Kawamura H, Aiba M: [Adult choroid plexus papilloma of the posterior fossa: extraventricular location]. No Shinkei Geka; 2005 Aug;33(8):825-9
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  • [Title] [Adult choroid plexus papilloma of the posterior fossa: extraventricular location].
  • Choroid plexus papillomas (CPPs) are rare neuroectodermal neoplasms accounting for 0.4% of all intracranial neoplasms in adults.
  • It is difficult to diagnose CPP preoperatively when the main portion of the tumor is not located in the 4th ventricle.
  • We present a case of a 54-year-old male manifesting slurred speech, nystagmus and cerebellar ataxia.
  • Magnetic resonance imaging demonstrated an intracerebellar solid tumor with multilocular cysts, extending towards both the right lateral medullary region and the foramen of Luschka.
  • Angiographically, via the right posterior inferior cerebellar artery revealed the tumor was faintly opacified.
  • Tumor was subtotally resected through a right suboccipital craniectomy.
  • CPP should be considered among calcified and enhanced masses in the lateral medullary to cerebellopontine angle space in adults, even if the main portion of the tumor is not located in the 4th ventricle.
  • [MeSH-major] Infratentorial Neoplasms / surgery. Papilloma, Choroid Plexus / surgery

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  • [ErratumIn] No Shinkei Geka. 2005 Oct;33(10):977
  • (PMID = 16095214.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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23. Holak H, Holak S, Holak N, Loel U: [Genetic diagnostic methods in ataxia-telangiectasia (Louis-Bar syndrome)]. Klin Oczna; 2006;108(7-9):340-5
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  • RESULTS: Cerebellar atrophy in MRT was associated with typical neuroophthalmological symptoms.
  • [MeSH-minor] Adult. Ataxia Telangiectasia Mutated Proteins. Biomarkers / metabolism. Cell Cycle. Cell Cycle Proteins / metabolism. DNA-Binding Proteins / metabolism. Genetic Markers. Humans. Karyotyping / methods. Male. Neurologic Examination. Protein-Serine-Threonine Kinases / metabolism. Tumor Suppressor Proteins / metabolism. alpha-Fetoproteins / metabolism

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  • (PMID = 17290839.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / Tumor Suppressor Proteins; 0 / alpha-Fetoproteins; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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24. Menon G, Krishnakumar K, Nair S: Adult medulloblastoma: clinical profile and treatment results of 18 patients. J Clin Neurosci; 2008 Feb;15(2):122-6
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  • [Title] Adult medulloblastoma: clinical profile and treatment results of 18 patients.
  • The objective of this article is to examine the clinicoradiological features and surgical outcomes of adult patients (>16 years) with medulloblastoma.
  • The tumor was located in the vermis in 12 patients (66.6%) and in the cerebellar hemisphere in six (16.6%).
  • Desmoplastic variant histology was not observed to be a significant prognostic factor in the adult group while brain stem invasion carried a poor prognosis.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Clinical Trials as Topic. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Statistics, Nonparametric. Treatment Outcome

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  • (PMID = 18078755.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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25. Bunin GR, Kushi LH, Gallagher PR, Rorke-Adams LB, McBride ML, Cnaan A: Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States). Cancer Causes Control; 2005 Sep;16(7):877-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fruit, vegetables, vitamin C, and folate during pregnancy have been suggested as protective factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children.
  • As hypothesized, cured meats were not associated with medulloblastoma/PNET, in contrast to other childhood brain tumors.
  • [MeSH-major] Cerebellar Neoplasms / epidemiology. Food Habits. Medulloblastoma / epidemiology
  • [MeSH-minor] Adult. Antioxidants / administration & dosage. Ascorbic Acid / administration & dosage. Candy / adverse effects. Female. Folic Acid / administration & dosage. Fruit. Humans. Maternal Welfare. Meat / adverse effects. Micronutrients. Odds Ratio. Pregnancy. United States / epidemiology. Vegetables. Vitamin B Complex / administration & dosage

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  • (PMID = 16132798.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA15488; United States / NCI NIH HHS / CA / CA60951
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Micronutrients; 12001-76-2 / Vitamin B Complex; 935E97BOY8 / Folic Acid; PQ6CK8PD0R / Ascorbic Acid
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26. Shiobara R, Ohira T, Inoue Y, Kanzaki J, Kawase T: Extended middle cranial fossa approach for vestibular schwannoma: technical note and surgical results of 896 operations. Prog Neurol Surg; 2008;21:65-72
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  • With this approach, the operative field can be extended according to tumor size and the facial and cochlear nerves can be preserved more easily with cooperation between the neurosurgeon and ENT surgeon.
  • In the 760 initially operated vestibular schwannomas with total removal of the tumor, facial nerves were anatomically preserved in 715 or 94.1% of the cases.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle. Cranial Fossa, Middle / surgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Cohort Studies. Female. Hearing Loss / etiology. Hearing Loss / prevention & control. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18810200.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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27. Skalova A, Síma R, Bohus P, Curík R, Lukás J, Michal M: Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene. Pathol Res Pract; 2008;204(8):599-606
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene.
  • Endolymphatic sac tumor (Heffner tumor) (ELST) is a very rare nonmetastasizing, locally aggressive low-grade adenocarcinoma of endolymphatic sac origin, which is linked to von-Hippel-Lindau disease (VHLD).
  • The tissues obtained from Heffner tumor and cerebellar hemangioblastoma from the patient with inherited VHLD possess a point mutation in exon 1 of VHL gene.
  • [MeSH-major] Adenocarcinoma / genetics. Ear Neoplasms / genetics. Ear, Middle / pathology. Endolymphatic Sac / pathology. Gene Expression Regulation, Neoplastic. Skull Neoplasms / genetics. Temporal Bone / pathology. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics
  • [MeSH-minor] Adult. Aged. DNA Mutational Analysis. Exons. Female. Genetic Predisposition to Disease. Humans. Introns. Neoplasm Invasiveness. Pedigree. Point Mutation

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  • (PMID = 18423895.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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28. Gyure KA: Newly defined central nervous system neoplasms. Am J Clin Pathol; 2005 Jun;123 Suppl:S3-12
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  • [Title] Newly defined central nervous system neoplasms.
  • In recent years, numerous new entities or variants of recognized central nervous system tumors have been described in the literature, and the morphologic spectrum of these neoplasms is delineated incompletely.
  • The clinicopathologic features and differential diagnosis of 4 new entities, including the chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and papillary glioneuronal tumor, are discussed in this review.
  • [MeSH-major] Central Nervous System Neoplasms / classification. Central Nervous System Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cerebellar Neoplasms / classification. Cerebellar Neoplasms / diagnosis. Child. Chordoma / classification. Chordoma / diagnosis. Diagnosis, Differential. Female. Ganglioglioma / classification. Ganglioglioma / diagnosis. Glioma / diagnosis. Glioma / pathology. Humans. Hypothalamic Neoplasms / classification. Hypothalamic Neoplasms / diagnosis. Male. Medulloblastoma / classification. Medulloblastoma / diagnosis. Prognosis. Rhabdoid Tumor / classification. Rhabdoid Tumor / diagnosis. Teratoma / classification. Teratoma / diagnosis. Third Ventricle / pathology

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  • (PMID = 16100866.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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29. Schönemeier B, Kolodziej A, Schulz S, Jacobs S, Hoellt V, Stumm R: Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. J Comp Neurol; 2008 Sep 10;510(2):207-20
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  • [Title] Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain.
  • In the adult brain the SDF-1/CXCR4 system was implicated in neurogenesis, neuromodulation, brain inflammation, tumor growth, and HIV encephalopathy.
  • Here we provide the first map of CXCR7 mRNA expression in the embryonic and adult rat brain.
  • Unlike CXCR4, CXCR7 was abundant in neurons forming the cortical plate and sparse in the developing dentate gyrus and cerebellar external germinal layer.
  • In the adult brain, CXCR7 was expressed by blood vessels, pyramidal cells in CA3, and mature dentate gyrus granule cells, which is reminiscent of the SDF-1 pattern.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18615560.001).
  • [ISSN] 1096-9861
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokine CXCL12; 0 / Cmkor1 protein, rat; 0 / Cxcr4 protein, rat; 0 / Receptors, CXCR; 0 / Receptors, CXCR4; 0 / Receptors, G-Protein-Coupled; 56-12-2 / gamma-Aminobutyric Acid
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30. Kagawa N, Maruno M, Suzuki T, Hashiba T, Hashimoto N, Izumoto S, Yoshimine T: Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays. Brain Tumor Pathol; 2006 Apr;23(1):41-7
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  • [Title] Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays.
  • Medulloblastoma (MB) is the most frequent infratentorial malignant brain tumor in children.
  • In contrast, primitive neuroectodermal tumor (PNET) is defined as a supratentorial malignant tumor generated from the cerebral hemisphere.
  • These tumors have considerable histological overlap but have different clinical outcomes including overall survival period, recurrence rate, and chemosensitivity.
  • Genes that are frequently amplified in these both these tumors include MSH2, N-myc, AKT3, and EGFR.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Chromosome Aberrations. DNA, Neoplasm / genetics. Medulloblastoma / genetics. Medulloblastoma / pathology. Neuroectodermal Tumors, Primitive / genetics. Neuroectodermal Tumors, Primitive / pathology
  • [MeSH-minor] Biomarkers, Tumor. Cerebellum / pathology. Child. Child, Preschool. Female. Humans. In Situ Hybridization. Infant. Male. Microarray Analysis. Young Adult


31. Capovilla M, Kambouchner M, Bernier M, Soulier A, Tissier F, Saintigny P: Late cerebellar relapse of a juvenile bronchial carcinoid. Clin Lung Cancer; 2007 Mar;8(5):339-41
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  • [Title] Late cerebellar relapse of a juvenile bronchial carcinoid.
  • Although epithelial bronchial neoplasm is a cancer frequently observed in adult patients, it is rarely observed in patients who are children.
  • The most frequent histologic subtype is well differentiated neuroendocrine tumor, or carcinoid.
  • They have a variable biologic behavior, ranging from benign to malignant tumors capable of very late recurrence or metastasis.
  • We report the case of a child with a pulmonary carcinoid initially considered typical, who presented with relapse in the cerebellum and mediastinum 16 years later.
  • After review of the pathology slides, primary and metastatic tumors were reclassified as atypical carcinoid according to the criteria of the 2004 World Health Organization classification of lung tumors.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / secondary
  • [MeSH-minor] Adolescent. Adult. Humans. Male

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  • (PMID = 17562235.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Rorke-Adams LB, Portnoy H: Long-term survival of an infant with gliomatosis cerebelli. J Neurosurg Pediatr; 2008 Nov;2(5):346-50
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  • Gliomatosis cerebri is an uncommon but well-established central nervous system neoplasm that occurs primarily in adults.
  • Although the neoplastic process typically arises in the cerebrum, it often spreads to brainstem, cerebellum, or even the spinal cord.
  • In this report the authors document the surgical treatment of a 13-month-old boy whose tumor arose in the cerebellum and over time extended to the thalamus where its growth halted at age 3 years and 10 months.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Neoplasms, Neuroepithelial / pathology. Neoplasms, Neuroepithelial / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Humans. Infant. Male. Neoplasm Invasiveness. Treatment Outcome

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  • (PMID = 18976105.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Shim KW, Joo SY, Kim SH, Choi JU, Kim DS: Prediction of prognosis in children with medulloblastoma by using immunohistochemical analysis and tissue microarray. J Neurosurg Pediatr; 2008 Mar;1(3):196-205
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  • OBJECTIVES: Medulloblastoma is the most common malignant neuroepithelial tumor found in children.
  • In addition, the authors tried to determine the prognostic utility of these results in this tumor category.
  • RESULTS: There was no statistically significant correlation between the prognosis and the degree of cell differentiation, but a positive correlation was noted between the PI and the AI in a tumor mass.
  • The number of cases with a PI > 10% was significantly greater in the group of tumors in patients with recurrent medulloblastoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adolescent. Adult. Apoptosis / physiology. Cell Differentiation / physiology. Cell Proliferation. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Follow-Up Studies. Forecasting. Humans. Immunohistochemistry. Male. Microarray Analysis. Neoadjuvant Therapy. Neoplasm Recurrence, Local / pathology. Prognosis. Radiotherapy, Adjuvant. Receptor, ErbB-3 / analysis. Receptor, trkC / analysis. Retrospective Studies. Treatment Outcome


34. Baker KA, Mendez I: Long distance selective fiber outgrowth of transplanted hNT neurons in white matter tracts of the adult rat brain. J Comp Neurol; 2005 Jun 13;486(4):318-30
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  • [Title] Long distance selective fiber outgrowth of transplanted hNT neurons in white matter tracts of the adult rat brain.
  • Fewer fibers were associated with the superior cerebellar peduncle, medial lemniscus, and nigrostriatal pathway.
  • These pathways were seen in all grafted animals, suggesting that specific guidance cues exist in the adult brain governing hNT fiber outgrowth.
  • Injured adult axons and transplanted embryonic neuronal axons rarely extend for such distances in the adult nervous system.
  • We propose that elucidating the factors promoting and guiding hNT axonal outgrowth could provide important clues to enhancing regeneration and target reinnervation in the adult brain, two factors of critical importance for cell restoration strategies aimed at brain repair.
  • [MeSH-minor] Adrenergic Agents / toxicity. Amphetamine / pharmacology. Animals. Axons / physiology. Behavior, Animal / drug effects. Cell Differentiation / drug effects. Cell Line, Tumor. Cell Transplantation / methods. Cyclosporine / pharmacology. Female. Functional Laterality. Graft Survival / drug effects. Graft Survival / physiology. Humans. Immunosuppressive Agents / pharmacology. Motor Activity / drug effects. Neural Pathways / drug effects. Neural Pathways / physiology. Neural Pathways / surgery. Neurites / physiology. Oxidopamine / toxicity. Phosphopyruvate Hydratase / metabolism. Random Allocation. Rats. Rats, Wistar. Rotarod Performance Test / methods. Teratocarcinoma. Transplantation, Heterologous. Tyrosine 3-Monooxygenase / metabolism

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15846787.001).
  • [ISSN] 0021-9967
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic Agents; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine; 8HW4YBZ748 / Oxidopamine; CK833KGX7E / Amphetamine; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; EC 4.2.1.11 / Phosphopyruvate Hydratase
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35. Rubello D, Vitaliani R, Rigoni MT, Rampin L, Giometto B, Casara D, Zonzin GC, Zavagno G, Capirci C, Shapiro B, Muzzio PC: A rare case of paraneoplastic cerebellar degeneration discovered by whole-body F-18 FDG PET. Clin Nucl Med; 2005 Oct;30(10):704-6
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  • [Title] A rare case of paraneoplastic cerebellar degeneration discovered by whole-body F-18 FDG PET.
  • A rare case of paraneoplastic cerebellar degeneration (PCD) in a 36-year-old woman is reported.
  • No tumor was found until April 2003; repeated CT scan, ultrasound, and mammographic examinations were negative.
  • In the reported case, F-18 FDG PET played a crucial role in detecting the unknown primary tumor in a young patient with PCD.
  • [MeSH-major] Breast Neoplasms / complications. Breast Neoplasms / diagnosis. Fluorodeoxyglucose F18. Paraneoplastic Cerebellar Degeneration / diagnosis. Paraneoplastic Cerebellar Degeneration / etiology. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods. Whole Body Imaging / methods
  • [MeSH-minor] Adult. Female. Humans. Radiopharmaceuticals. Rare Diseases / diagnosis


36. Chen GJ, Karajannis MA, Newcomb EW, Zagzag D: Overexpression and activation of epidermal growth factor receptor in hemangioblastomas. J Neurooncol; 2010 Sep;99(2):195-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumors are characterized by a dense network of blood capillaries, often in association with cysts.
  • Although activation of receptor tyrosine kinase (RTK) signaling, including epidermal growth factor receptor (EGFR) has been implicated in the development of malignant brain tumors such as high-grade gliomas, little is known about the role of RTK signaling in hemangioblastomas.
  • To address this issue, we examined hemangioblastoma tumor specimens using receptor tyrosine kinase (RTK) activation profiling and immunohistochemistry.
  • Six human hemangioblastomas were analyzed with a phospho-RTK antibody array, revealing EGFR phosphorylation in all tumors.
  • EGFR expression was confirmed by immunohistochemistry in all tumors analyzed and downstream effector pathway activation was demonstrated by positive staining for phospho-AKT.

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  • (PMID = 20730556.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA100426-01A1; United States / NCI NIH HHS / CA / R01 CA100426; United States / NCI NIH HHS / CA / R01 CA100426-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS194899; NLM/ PMC2928155
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37. Wang Y, Wang Y, Gao X, Wang Y: Intraoperative sonographically guided resection of hemangioblastoma in the cerebellum. J Clin Ultrasound; 2006 Jun;34(5):247-9
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  • [Title] Intraoperative sonographically guided resection of hemangioblastoma in the cerebellum.
  • Intraoperative sonography was used to significantly reduce the duration of the intervention and ensure thorough resection of the tumor.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellum / surgery. Cerebellum / ultrasonography. Hemangioblastoma / surgery. Intraoperative Care / methods
  • [MeSH-minor] Adult. Female. Humans. Neurosurgical Procedures

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  • (PMID = 16673369.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Ng D, Stavrou T, Liu L, Taylor MD, Gold B, Dean M, Kelley MJ, Dubovsky EC, Vezina G, Nicholson HS, Byrne J, Rutka JT, Hogg D, Reaman GH, Goldstein AM: Retrospective family study of childhood medulloblastoma. Am J Med Genet A; 2005 May 1;134(4):399-403
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Medulloblastoma is the most common malignant central nervous system tumor of childhood and can occur sporadically or in association with inherited cancer susceptibility syndromes such as the nevoid basal cell carcinoma syndrome (NBCCS).
  • Six patients had tumors showing desmoplastic histology.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA / chemistry. DNA / genetics. DNA Mutational Analysis. DNA-Binding Proteins / genetics. Female. Humans. Infant. Kruppel-Like Transcription Factors. Male. Mutation. Nerve Tissue Proteins / genetics. Pedigree. Receptors, Cell Surface / genetics. Repressor Proteins / genetics. Retrospective Studies. Transcription Factors / genetics

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • [ErratumIn] Am J Med Genet A. 2005 Jul 15;136(2):226
  • (PMID = 15759260.001).
  • [ISSN] 1552-4825
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / GLI3 protein, human; 0 / Kruppel-Like Transcription Factors; 0 / Nerve Tissue Proteins; 0 / Receptors, Cell Surface; 0 / Repressor Proteins; 0 / SUFU protein, human; 0 / Transcription Factors; 0 / patched receptors; 9007-49-2 / DNA
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39. Tabori U, Sung L, Hukin J, Laperriere N, Crooks B, Carret AS, Silva M, Odame I, Mpofu C, Strother D, Wilson B, Samson Y, Bouffet E, Canadian Pediatric Brain Tumor Consortium: Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma. Int J Radiat Oncol Biol Phys; 2006 Feb 1;64(2):402-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / mortality. Medulloblastoma / mortality. Neoplasm Recurrence, Local / mortality
  • [MeSH-minor] Adolescent. Adult. Age Factors. Analysis of Variance. Child. Disease-Free Survival. Female. Humans. Male. Prognosis. Recurrence. Retrospective Studies. Sex Factors

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  • (PMID = 16198067.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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40. Chelly I, Mekni A, Kchir N, Karim BH, Khadija B, Selma B, Slim H, Khaldi M, Zitouna M: Intracerebellar granulocytic sarcoma. A case report. Pathologica; 2005 Oct;97(5):335-7
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  • We report a case of cerebellar granulocytic sarcoma occuring in a 43 years old woman without any precedent medical history.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Sarcoma, Myeloid / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Carboxylic Ester Hydrolases / analysis. Fatal Outcome. Female. Headache / etiology. Hepatomegaly / etiology. Humans. Immunoenzyme Techniques. Muramidase / analysis. Neoplasm Proteins / analysis. Peroxidase / analysis. Splenomegaly / etiology. Staining and Labeling

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  • (PMID = 16480032.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / Neoplasm Proteins; EC 1.11.1.7 / Peroxidase; EC 3.1.1.- / Carboxylic Ester Hydrolases; EC 3.1.1.- / chloroacetate esterase; EC 3.2.1.17 / Muramidase
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41. Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL: Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res; 2005 Jul 15;65(14):6178-88
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  • The genetic hallmark of hemangioblastomas and clear cell-renal cell carcinomas (CC-RCCs) is loss-of-function of the von Hippel-Lindau (VHL) tumor suppressor protein.
  • Immunohistochemistry revealed overexpression of both CXCR4 and SDF-1alpha within tumor cells and endothelial cells of hemangioblastomas and CC-RCCs.
  • HIF-1alpha was detected in tumor cell nuclei of both hemangioblastomas and CC-RCCs.
  • These results suggest that loss-of-function of a single tumor suppressor gene can up-regulate the expression of both a ligand and its receptor, which may establish an autocrine signaling pathway with important roles in the pathogenesis of hemangioblastoma and CC-RCC.
  • [MeSH-major] Adenocarcinoma, Clear Cell / metabolism. Cerebellar Neoplasms / metabolism. Chemokines, CXC / biosynthesis. Hemangioblastoma / metabolism. Kidney Neoplasms / metabolism. Receptors, CXCR4 / biosynthesis. Tumor Suppressor Proteins / physiology. Ubiquitin-Protein Ligases / physiology
  • [MeSH-minor] Adolescent. Adult. Aged. Animals. Cell Line, Tumor. Cell Nucleus / metabolism. Chemokine CXCL12. Cytosol / metabolism. Enzyme-Linked Immunosorbent Assay. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Mice. Middle Aged. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Signal Transduction. Transfection. Up-Regulation. Vascular Endothelial Growth Factor A / biosynthesis. Vascular Endothelial Growth Factor A / genetics. Von Hippel-Lindau Tumor Suppressor Protein

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  • (PMID = 16024619.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50-CA103175; United States / NCI NIH HHS / CA / R01-CA100426; United States / NHLBI NIH HHS / HL / R01-HL55338
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CXCL12 protein, human; 0 / Chemokine CXCL12; 0 / Chemokines, CXC; 0 / Cxcl12 protein, mouse; 0 / RNA, Messenger; 0 / Receptors, CXCR4; 0 / Tumor Suppressor Proteins; 0 / Vascular Endothelial Growth Factor A; EC 6.3.2.19 / Ubiquitin-Protein Ligases; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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42. Suyama K, Ujifuku K, Hirao T, Takahata H, Ito M, Yonekura M, Nagata I: Symptomatic syringomyelia associated with a dermoid tumor in the posterior fossa. Neurol Med Chir (Tokyo); 2009 Sep;49(9):434-7
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  • [Title] Symptomatic syringomyelia associated with a dermoid tumor in the posterior fossa.
  • A 28-year-old female presented with a dermoid tumor in the posterior fossa associated with symptomatic syringomyelia.
  • Magnetic resonance (MR) imaging revealed cervical syringomyelia and tonsillar herniation concomitant with an intradural posterior fossa tumor which was totally removed.
  • The histological diagnosis was dermoid tumor.
  • Her symptoms subsided and MR imaging demonstrated complete resolution of the syrinx 12 months after tumor removal.
  • Benign congenital intracranial tumor may cause tonsillar herniation resulting in symptomatic cervical syringomyelia.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cranial Fossa, Posterior / pathology. Dermoid Cyst / pathology. Infratentorial Neoplasms / pathology. Syringomyelia / etiology
  • [MeSH-minor] Adult. Cerebrospinal Fluid Pressure / physiology. Decompression, Surgical. Encephalocele / etiology. Encephalocele / physiopathology. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures. Treatment Outcome

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  • (PMID = 19779293.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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43. Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M: Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol; 2006 Jun-Jul;27(6):1362-9
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  • [Title] Apparent diffusion coefficients for differentiation of cerebellar tumors in children.
  • We hypothesized that cerebellar tumors in children can be differentiated by their ADC values.
  • METHODS: Brain MR imaging studies that included ADC maps were retrospectively reviewed in 32 patients with histologically proved cerebellar neoplasm.
  • There were 17 juvenile pilocytic astrocytomas (JPA), 8 medulloblastomas, 5 ependymomas, and 2 rhabdoid (atypical teratoid/rhabdoid tumor [AT/RT]) tumors.
  • Absolute ADC values of contrast-enhancing solid tumor regions and ADC ratios (ADC of solid tumor to ADC of normal-appearing white matter) were compared with the histologic diagnosis.
  • ADC ratios were also significantly different among these 3 tumor types.
  • CONCLUSION: Assessment of ADC values of enhancing solid tumor is a simple and reliable technique for preoperative differentiation of cerebellar tumors in pediatric patients.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Astrocytoma / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / diagnosis. Ependymoma / pathology. Female. Humans. Infant. Male. Medulloblastoma / diagnosis. Medulloblastoma / pathology

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  • [CommentIn] Nat Clin Pract Neurol. 2007 Feb;3(2):78-9 [17279080.001]
  • (PMID = 16775298.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Caprile T, Salazar K, Astuya A, Cisternas P, Silva-Alvarez C, Montecinos H, Millán C, de Los Angeles García M, Nualart F: The Na+-dependent L-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids. J Neurochem; 2009 Feb;108(3):563-77
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  • In the adult brain the expression of SVCT2 was observed in the hippocampus and cortical neurons by in situ hybridization; however, there is no data regarding the expression and distribution of this transporter in the fetal brain.
  • SVCT2 expression and function was also confirmed in neurons isolated from brain cortex and cerebellum.
  • Our data demonstrates that brain cortex and cerebellar stem cells, neurons and neuroblastoma cells express SVCT2.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Stem / metabolism. Flavonoids / pharmacology. Neuroblastoma / metabolism. Neurons / metabolism. Organic Anion Transporters, Sodium-Dependent / antagonists & inhibitors. Organic Anion Transporters, Sodium-Dependent / biosynthesis. Sodium / physiology. Symporters / antagonists & inhibitors. Symporters / biosynthesis
  • [MeSH-minor] Animals. Ascorbic Acid / metabolism. Blotting, Western. Cell Line, Tumor. Cerebellum / cytology. Cerebellum / drug effects. Cerebellum / metabolism. Cerebral Cortex / cytology. Cerebral Cortex / drug effects. Cerebral Cortex / metabolism. DNA, Complementary / biosynthesis. DNA, Complementary / genetics. Female. Humans. Immunohistochemistry. In Situ Hybridization. Kinetics. Mice. Pregnancy. Rats. Rats, Sprague-Dawley. Reverse Transcriptase Polymerase Chain Reaction. Sodium-Coupled Vitamin C Transporters

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  • (PMID = 19054284.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Flavonoids; 0 / Organic Anion Transporters, Sodium-Dependent; 0 / SLC23A1 protein, human; 0 / SLC23A2 protein, human; 0 / Slc23a1 protein, mouse; 0 / Slc23a1 protein, rat; 0 / Slc23a2 protein, mouse; 0 / Slc23a2 protein, rat; 0 / Sodium-Coupled Vitamin C Transporters; 0 / Symporters; 9NEZ333N27 / Sodium; PQ6CK8PD0R / Ascorbic Acid
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45. Pimentel J, Resende M, Vaz A, Reis AM, Campos A, Carvalho H, Honavar M: Rosette-forming glioneuronal tumor: pathology case report. Neurosurgery; 2008 May;62(5):E1162-3; discussion E1163
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  • [Title] Rosette-forming glioneuronal tumor: pathology case report.
  • OBJECTIVE: Rosette-forming glioneuronal tumor is a newly described mixed glial and neuronal tumor.
  • METHODS: Patients were surgically treated, and tumors were diagnosed by light microscopy and immunohistochemistry using the avidin-biotin complex method.
  • Magnetic resonance imaging revealed a right paramedian cerebellar cystic and nodular mass and a separate nodule in the vermis, which were excised gross totally with no morbidity.
  • Microscopic examination showed neuroepithelial tumors composed of neurocytic cells focally forming well-defined rosettes that were immunopositive for neuronal markers and of elongated, glial fibrillary acidic protein-immunoreactive astrocytes.
  • Eighteen rosette-forming glioneuronal tumors were identified with the literature search.
  • CONCLUSION: These are tumors of young adulthood (range, 12-59 yr) usually in or close to the fourth ventricle.
  • They are composed of neurocytic and glial elements, probably arising from a common progenitor in the subependymal plate, and need to be differentiated from a variety of glioneuronal tumors.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Ganglioglioma / pathology
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures

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  • (PMID = 18580784.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Patrick TA, Giannini C, Ebersold MJ, Link MJ: Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report. J Neurosurg; 2006 Mar;104(3):452-6
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  • [Title] Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report.
  • Metastatic seeding or iatrogenic implantation of numerous types of primary central nervous system tumors, typically along cerebrospinal fluid pathways, is a frequently described albeit rare phenomenon and has never been reported in association with vestibular schwannoma (VS).
  • The authors present a case of inadvertent surgical implantation of VS into the cerebellar hemisphere during resection of a recurrent VS in the cerebellopontine angle and internal auditory canal.
  • Five years later--10 years after initial presentation--follow-up imaging revealed a 1-cm recurrence of the VS and a separate 2.2-cm tumor in the inferior cerebellar parenchyma with surrounding edema.
  • Both tumors were removed without complication by reopening the previous retrosigmoid craniotomy.
  • Histological evaluation of these tumors revealed features typical of VS and similar to those of the tissue obtained from the two prior resections.
  • Given the similarities among these tumors in pathological appearance and mitotic index, the presence of the intraparenchymal cerebellar schwannoma was probably due to intraoperative iatrogenic implantation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Neuroma, Acoustic / etiology
  • [MeSH-minor] Adult. Cerebellopontine Angle / pathology. Humans. Iatrogenic Disease. Male. Mitotic Index. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16572663.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Corns R, Crocker M, Kumar A, Salisbury J, Tolias C, Sadler G, Hill M: Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report. Acta Neurochir (Wien); 2010 Jun;152(6):1075-7
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  • [Title] Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report.
  • We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Cranial Irradiation. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / radiotherapy. Methotrexate / therapeutic use
  • [MeSH-minor] Adult. Antineoplastic Agents, Hormonal / therapeutic use. Biomarkers, Tumor / analysis. Biopsy. Cerebellum / pathology. Combined Modality Therapy. Dexamethasone / therapeutic use. Dose-Response Relationship, Drug. Female. Humans. Infusions, Intravenous. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Neurologic Examination. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 19936608.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 7S5I7G3JQL / Dexamethasone; YL5FZ2Y5U1 / Methotrexate
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48. Myong NH, Park BJ: Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient. Yonsei Med J; 2009 Aug 31;50(4):576-81
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  • [Title] Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient.
  • The patient was a 25 year-old male with multiple hemangioblastomas at the cerebellum and spinal cord, multiple pancreatic cysts and a renal cell carcinoma; he was diagnosed as having VHL disease.
  • The largest hemangioblastoma at the right cerebellar hemisphere was completely removed, and he received high-dose irradiation postoperatively.
  • The tumor recurred at the same site 7 years later, which was a malignant glioma with no evidence of hemangioblastoma.
  • The malignant glioma showed molecular genetic profiles of radiation-induced tumors because of its diffuse p53 immunostaining and the loss of p16 immunoreactivity.
  • The genetic study to find the loss of heterozygosity (LOH) of VHL gene revealed that only the cerebellar hemangioblastoma showed allelic losses for the gene.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Glioma / diagnosis. Glioma / etiology. Hemangioblastoma / surgery. Radiotherapy / adverse effects. von Hippel-Lindau Disease / radiotherapy
  • [MeSH-minor] Adult. Humans. Male


49. Ali Y, Rahme R, Moussa R, Abadjian G, Menassa-Moussa L, Samaha E: Multifocal meningeal melanocytoma: a new pathological entity or the result of leptomeningeal seeding? J Neurosurg; 2009 Sep;111(3):488-91
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  • Meningeal melanocytoma is a rare benign CNS tumor derived from the leptomeningeal melanocytes.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle. Melanocytes / pathology. Melanoma / pathology. Meningeal Neoplasms / pathology. Neoplasm Seeding. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19361258.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Dezmalj-Grbelja L, Bosnjak J, Lovrencić-Huzjan A, Ivica M, Demarin V: Moyamoya disease in a patient with brain tumor: case report. Acta Clin Croat; 2010 Dec;49(4):459-63
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  • [Title] Moyamoya disease in a patient with brain tumor: case report.
  • Nuclear magnetic resonance (NMR) showed vascular lesions in the white matter and infratentorially an expansive lesion with no postcontrast imbibition in the right cerebellar hemisphere.
  • We recommended neurosurgical operation of brain tumor.
  • This case is interesting because of the rare complex cerebrovascular disease, i.e. coexistence ofhypoplasia of both ICA, bilateral subtotal stenosis of ICA, intracranial moyamoya disease, and brain tumor.
  • [MeSH-major] Brain Neoplasms / complications. Moyamoya Disease / diagnosis
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Angiography. Magnetic Resonance Spectroscopy. Male. Radiographic Image Enhancement

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  • (PMID = 21830458.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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51. Comincini S, Ferrara V, Arias A, Malovini A, Azzalin A, Ferretti L, Benericetti E, Cardarelli M, Gerosa M, Passarin MG, Turazzi S, Bellazzi R: Diagnostic value of PRND gene expression profiles in astrocytomas: relationship to tumor grades of malignancy. Oncol Rep; 2007 May;17(5):989-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of PRND gene expression profiles in astrocytomas: relationship to tumor grades of malignancy.
  • It is abundant in testis and, unlike PRNP, it is expressed at low levels in the adult central nervous system (CNS).
  • Besides, doppel overexpression correlates with some prion-disease pathological features, such as ataxia and death of cerebellar neurons.
  • Recently, ectopic expression of doppel was found in two different tumor types, specifically in glial and haematological cancers.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Prions / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Algorithms. Child. Cluster Analysis. Female. GPI-Linked Proteins. Gene Expression Profiling. Glioblastoma / genetics. Glioblastoma / metabolism. Glioblastoma / pathology. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 17390034.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / PRND protein, human; 0 / Prions
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52. Gururangan S, Krauser J, Watral MA, Driscoll T, Larrier N, Reardon DA, Rich JN, Quinn JA, Vredenburgh JJ, Desjardins A, McLendon RE, Fuchs H, Kurtzberg J, Friedman HS: Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. Neuro Oncol; 2008 Oct;10(5):745-51
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  • All patients in groups B and C have died of tumor, at a median of 35 months and 26 months from HDC and standard salvage therapy, respectively.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Salvage Therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Humans. Kaplan-Meier Estimate. Retrospective Studies


53. Saikali S, Le Strat A, Heckly A, Stock N, Scarabin JM, Hamlat A: Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature. J Neurosurg; 2005 Feb;102(2):376-81
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  • Although the occipital lesion was cured surgically, the cerebellar tumor recurred three times and underwent malignant transformation into an anaplastic oligodendroglioma.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Neurofibromatosis 1 / surgery
  • [MeSH-minor] Adult. Brain / pathology. Brain / surgery. Cell Transformation, Neoplastic / pathology. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellum / pathology. Cerebellum / surgery. Disease Progression. Female. Humans. Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Occipital Lobe / pathology. Occipital Lobe / surgery. Oligodendroglioma / pathology


54. Schoch B, Hogan A, Gizewski ER, Timmann D, Konczak J: Balance control in sitting and standing in children and young adults with benign cerebellar tumors. Cerebellum; 2010 Sep;9(3):324-35
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  • [Title] Balance control in sitting and standing in children and young adults with benign cerebellar tumors.
  • Children and young adolescents with chronic surgical cerebellar lesions show persistent balance control problems during standing when lesions affect the deep cerebellar fastigial and adjacent interposed nuclei.
  • Balance control was assessed in 16 patients after surgery of a benign cerebellar tumor in chronic state and healthy age- and gender-matched control subjects.
  • High-resolution MRI scans were acquired in the cerebellar patients.
  • During sitting, 56% of cerebellar patients exhibited trunkal sway outside the range of healthy controls, and 87.5% of cerebellar patients revealed abnormal sway patterns during standing.
  • In patients with surgery <1-year lesions of the inferior cerebellar vermis also had an impact on balance function.
  • Our results corroborate previous evidence that the extent of permanent damage to the deep cerebellar nuclei greatly impacts on the recovery on balance function.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Neurosurgical Procedures / adverse effects. Postoperative Complications / physiopathology. Postural Balance
  • [MeSH-minor] Adolescent. Adult. Biomechanical Phenomena. Cerebellum / pathology. Cerebellum / physiopathology. Cerebellum / surgery. Child. Female. Humans. Male. Posture. Young Adult

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  • (PMID = 20352395.001).
  • [ISSN] 1473-4230
  • [Journal-full-title] Cerebellum (London, England)
  • [ISO-abbreviation] Cerebellum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Sciubba DM, Gallia GL, Recinos P, Garonzik IM, Clatterbuck RE: Intracranial aneurysm following radiation therapy during childhood for a brain tumor. Case report and review of the literature. J Neurosurg; 2006 Aug;105(2 Suppl):134-9
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  • [Title] Intracranial aneurysm following radiation therapy during childhood for a brain tumor. Case report and review of the literature.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Intracranial Aneurysm / etiology. Medulloblastoma / radiotherapy. Radiotherapy / adverse effects
  • [MeSH-minor] Adult. Cerebral Angiography. Humans. Magnetic Resonance Imaging. Male. Middle Cerebral Artery / pathology. Middle Cerebral Artery / surgery


56. Dagostino C, Clara E, Chio A, Giordana MT: Morphophenotype of medulloblastoma in children and adults. The size of nuclei. Clin Neuropathol; 2006 Sep-Oct;25(5):227-31
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  • The aim of the present study was to compare the size of nuclei between pediatric and adult medulloblastomas by a morphometric analysis.
  • MATERIAL AND METHODS: In 79 neurosurgical specimens of cerebellar medulloblastomas, the maximum nuclear diameter of the largest nuclei was measured.
  • The distribution of maximum values measured in each case had two distinct peaks in the two age groups, in 3.5% of adult cases and in more than 30% of pediatric cases the maximum nuclear size was superior to 12 microm.
  • CONCLUSIONS: The present results show that nuclei of tumor cells in pediatric medulloblastomas are larger than those in adult medulloblastomas and confirm that the phenotype of medulloblastoma is different in the two age groups.
  • Distinct genetic events can, thus, underlie medulloblastoma in childhood and adult age, the prognostic role of genetic variables can differ by age.
  • [MeSH-major] Cell Nucleus / ultrastructure. Cerebellar Neoplasms / ultrastructure. Medulloblastoma / ultrastructure
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Child, Preschool. Female. Humans. Image Processing, Computer-Assisted. Infant. Male. Middle Aged. Prognosis

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  • (PMID = 17007445.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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57. Viana-Pereira M, Almeida I, Sousa S, Mahler-Araújo B, Seruca R, Pimentel J, Reis RM: Analysis of microsatellite instability in medulloblastoma. Neuro Oncol; 2009 Oct;11(5):458-67
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  • Medulloblastoma is the most common malignant brain tumor in children.
  • The presence of microsatellite instability (MSI) in brain tumors, particularly medulloblastomas, has not been properly addressed.
  • Among the 36 tumors, we found four (11%) cases with instability, one with high MSI and three with low MSI.
  • Methylation analysis of MMR genes in cases presenting shifts on the MSI markers revealed mild hypermethylation of MSH6 in 75% of cases, yet MSH6 was expressed in all the tumors.
  • The MSI target genes MBD4 (methyl-CpG binding domain protein 4) and MRE11 (meiotic recombination 11 homolog A) were mutated in two different tumors.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Microsatellite Instability
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. DNA Methylation. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Young Adult


58. Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D: The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J; 2007 Sep 5;26(17):4038-50
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  • The cellular prion protein, PrP(C), is neuroprotective in a number of settings and in particular prevents cerebellar degeneration mediated by CNS-expressed Doppel or internally deleted PrP ('DeltaPrP').
  • Here we demonstrate Sprn expression and Sho protein in the adult CNS.
  • Sho expression overlaps PrP(C), but is low in cerebellar granular neurons (CGNs) containing PrP(C) and high in PrP(C)-deficient dendritic processes.
  • [MeSH-minor] Amino Acid Sequence. Animals. Cell Line, Tumor. Cerebellum / metabolism. GPI-Linked Proteins. Hippocampus / metabolism. Mice. Molecular Sequence Data. Protein Binding


59. Tanaka K, Sasayama T, Nishihara M, Sakagami Y, Kondoh T, Ohbayashi C, Kohmura E: Rapid regrowth of an atypical choroid plexus papilloma located in the cerebellopontine angle. J Clin Neurosci; 2009 Jan;16(1):121-4
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  • CT scans and MRI showed a large extra-axial tumor in the right cerebellopontine angle.
  • Repeat imaging conducted 1 year after the operation showed that the tumor had recurred with distinct cystic features.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Cerebellopontine Angle / pathology. Choroid Plexus Neoplasms / pathology. Papilloma, Choroid Plexus / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Radiotherapy

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  • (PMID = 19008101.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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60. Tanioka D, Abe T, Ikeda H, Kushima M: [A case of cerebellar tuberculoma]. No Shinkei Geka; 2005 Sep;33(9):919-23
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  • [Title] [A case of cerebellar tuberculoma].
  • We report a case of cerebellar tuberculoma presenting with headache, without any specific data.
  • MRI demonstrated a mass lesion at the right cerebellum, suggesting the presence of a tuberculoma.
  • He underwent total removal of the tumor via the supracerebellar route.
  • The intracranial tuberculoma may be confused with an intracranial neoplasm.
  • In this report, we describe a cerebellar tuberculoma without any abnormal data, suggesting that intracranial tuberculoma should be considered in the differential diagnosis of any intracranial mass lesion.
  • [MeSH-major] Cerebellar Diseases / diagnosis. Tuberculoma / diagnosis
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 16164189.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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61. Cagliada MP, Carbone C, Ayala MA, Laborde JM, Maschi F, Milocco SN, Bonzo E, Cid De La Paz V, Galosi CM: Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina. Rev Argent Microbiol; 2010 Jan-Feb;42(1):27-9
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  • The clinical signs associated with a natural KRV infection include foetal resorption in dams, runting, ataxia, cerebellar hypoplasia and jaundice in suckling rats, and sudden death, scrotal cyanosis, abdominal swelling and dehydration in juvenile rats.
  • The ability of this virus to produce persistent infections has resulted in a high frequency of contamination of cell cultures and transplantable-tumor system.
  • This study determines the seroprevalence of Kilham antibodies from sera of adult rats from conventional facilities, using the haemagglutination inhibition test.

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  • (PMID = 20461290.001).
  • [ISSN] 0325-7541
  • [Journal-full-title] Revista Argentina de microbiología
  • [ISO-abbreviation] Rev. Argent. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Argentina
  • [Chemical-registry-number] 0 / Antibodies, Viral
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62. Han L, Zhang X, Qiu S, Li X, Xiong W, Zhang Y, Qu H, Chang R, Chen B, Wang W, Li S: Magnetic resonance imaging of primary cerebral gliosarcoma: a report of 15 cases. Acta Radiol; 2008 Nov;49(9):1058-67
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  • BACKGROUND: Gliosarcomas are rare tumors with mixed glial and mesenchymal components.
  • RESULTS: Apart from one tumor in the right cerebellar hemisphere, all were supratentorial.
  • Two tumors were intraventricular, and four involved the corpus callosum.
  • The tumors were well demarcated, with an inhomogeneous or cystic appearance and moderate-to-extensive surrounding edema.
  • These findings, combined with patient age, can aid the differential diagnosis of gliosarcomas from more common primary brain tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Gliosarcoma / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / pathology. Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / pathology. Corpus Callosum. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18766496.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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63. Gupta A, Ahmad FU, Sharma MC, Garg A, Mehta VS: Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report. J Neurosurg; 2007 Jun;106(6):1094-7
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  • [Title] Cerebellopontine angle meningeal melanocytoma: a rare tumor in an uncommon location. Case report.
  • Meningeal melanocytomas are uncommon intracranial tumors and their occurrence at the cerebellopontine angle (CPA) is extremely rare.
  • The authors describe the case of a 58-year-old woman who presented with a left CPA tumor; on the basis of histopathological studies after resection, a diagnosis of meningeal melanocytoma was reached.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Melanoma / pathology. Melanoma / surgery. Meningioma / pathology. Meningioma / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Melanins / metabolism. Neurosurgical Procedures

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  • (PMID = 17564187.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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64. Gauchotte G, Baylac F, Marie B, Vignaud JM: [Medullomyoblastoma: a medulloblastoma with rhabdomyoblastic differentiation]. Ann Pathol; 2010 Apr;30(2):135-8
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  • A 26 years old patient was operated for a tumor of cerebellar vermix, and then reoperated for a relapse at the age of 35 years, with a similar histological pattern in both cases.
  • At pathologic examination, the tumor was composed of hypercellular sheets typical of medulloblastoma, containing also sparse large cells with eosinophilic cytoplasm and round nuclei containing voluminous nucleoli.
  • The main differential diagnoses are atypical teratoid/rhabdoid tumor, immature teratoma, medulloepithelioma, primitive intracranial rhabdomyosarcoma and myoneurocytoma.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cell Differentiation. Desmin / analysis. Disease Progression. Fatal Outcome. Humans. Male. Muscle Cells / chemistry. Muscle Cells / pathology. Myogenin / analysis. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local / chemistry. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurofilament Proteins / analysis. Rhabdomyosarcoma / pathology. Synaptophysin / analysis

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20451073.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Myogenin; 0 / Neoplasm Proteins; 0 / Neurofilament Proteins; 0 / Synaptophysin
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65. Iwai Y, Yamanaka K: Gamma knife radiosurgery for other primary intra-axial tumors. Prog Neurol Surg; 2009;22:129-41
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  • [Title] Gamma knife radiosurgery for other primary intra-axial tumors.
  • We report the usefulness of gamma knife radiosurgery for hemangioblastomas, hemangiopericytomas, germ cell tumors and pineal parenchymal tumors, and primary central nervous system lymphoma (PCNSL).
  • In hemangioblastomas, small solid tumors can be treated very effectively.
  • Radiosurgery is a reasonable option to control residual and recurrent germ cell tumors and pineoblastomas.
  • Although the prognosis is poor for PCNSL patients, gamma knife radiosurgery, even with a relatively low tumor margin dose, is an effective treatment for controlling PCNSL.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Hemangiopericytoma / surgery. Neoplasms, Germ Cell and Embryonal / surgery. Pinealoma / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Lymphoma / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis

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  • (PMID = 18948725.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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66. Koch HJ, Roeber S, Zimmermann UW, Schäfer C, Villarrubia V, Kuchelmeister K, Schachenmayr W, Bogdahn U, Steinbrecher A: [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle]. Wien Med Wochenschr; 2005 Aug;155(15-16):360-4
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  • This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse.
  • [MeSH-major] Cerebellopontine Angle. Melanocytes / pathology. Melanoma. Meningeal Neoplasms. Meninges. Neoplasm Seeding
  • [MeSH-minor] Administration, Oral. Adult. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Arachnoid. Cerebellar Diseases / diagnosis. Cerebellar Neoplasms / diagnosis. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Diagnosis, Differential. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Pia Mater. Radiotherapy Dosage. Time Factors

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  • (PMID = 16160923.001).
  • [ISSN] 0043-5341
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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67. Jagannathan J, Lonser RR, Smith R, DeVroom HL, Oldfield EH: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg; 2008 Feb;108(2):210-22
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  • [Title] Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease.
  • OBJECT: Despite the frequency of cerebellar hemangioblastomas in von Hippel-Lindau (VHL) disease, their optimum contemporary management has not been defined, and is made complex because of the multiple, progressive, and protean nature of the tumors found in patients with this disorder.
  • To examine modern management and outcomes of cerebellar hemangioblastomas in VHL disease, the authors reviewed findings in patients with this disease who underwent resection of cerebellar hemangioblastomas.
  • METHODS: Consecutive patients with VHL disease who underwent surgery for cerebellar hemangioblastoma(s) at the National Institutes of Health were included.
  • Eighty consecutive patients (44 female and 36 male patients) underwent 126 operations for removal of 164 cerebellar hemangioblastomas (age at surgery 37.8+/-10.3 years, follow-up duration 96.0+/-60.3 months).
  • Tumors associated with symptoms were larger (diameter 1.8+/-1.9 cm; volume 2.8+/-3.4 cm3; p<0.05) and more likely to be associated with peritumoral edema or peritumoral cysts (100% associated with edema and/or cyst; p<0.05) than asymptomatic tumors (diameter 1.1+/-0.9 cm; volume 0.7+/-0.4 cm3; 18%).
  • More tumors were located in the posterior (74%) compared with the anterior (26%) half of the cerebellum (p<0.05).
  • Preoperative hydrocephalus resolved after tumor removal in 33 cases (94%) and did not require cerebrospinal fluid diversion.
  • CONCLUSIONS: Symptoms and signs caused by cerebellar hemangioblastomas in VHL disease are associated with edema and peritumoral cyst formation/propagation and are treated safely and effectively with resection.
  • Cerebrospinal fluid diversion is rarely necessary after complete tumor removal in patients with preoperative hydrocephalus.
  • Cerebellar hemangioblastomas are preferentially distributed in the posterior half of the cerebellum, as they are in the brainstem and spinal cord.
  • Tumor recurrence is avoided by meticulous extracapsular resection.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Ataxia / physiopathology. Brain Edema / physiopathology. Cerebellar Ataxia / physiopathology. Cranial Irradiation. Cysts / physiopathology. Dissection / methods. Electrocoagulation / methods. Female. Follow-Up Studies. Headache / physiopathology. Humans. Hydrocephalus / physiopathology. Male. Microdissection / methods. Postoperative Complications. Radiosurgery. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 18240914.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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68. Kasliwal MK, Suri A, Rishi A, Suri V, Sharma BS, Sarkar C: Symptomatic bilateral cerebellar mass lesions: an unusual presentation of intracranial xanthogranuloma. J Clin Neurosci; 2008 Dec;15(12):1401-4
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  • [Title] Symptomatic bilateral cerebellar mass lesions: an unusual presentation of intracranial xanthogranuloma.
  • Multicentric bilateral symptomatic cerebellar xanthogranuloma has not been reported previously.
  • We describe a 35-year-old man who presented with a complaint of vertigo, with nystagmus and left-side cerebellar signs found on clinical examination.
  • Radiological evaluation revealed bilateral cerebellar lesions abutting the cerebellopontine angle cistern.
  • The role of histopathology cannot be overemphasized in the diagnosis of this rare lesion and long-term follow-up is advised in cases managed conservatively owing to the propensity of this tumor to grow over time.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Granuloma / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 18952438.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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69. Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T: Genetic characterization of adult infratentorial gliomas. J Neurooncol; 2009 Feb;91(3):251-5
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  • [Title] Genetic characterization of adult infratentorial gliomas.
  • Adult infratentorial gliomas are rare and have not been well studied.
  • We therefore conducted genetic analysis of those tumors to see if there was any characteristic that could be relevant in clinical management and understanding of tumorigenesis.
  • Nineteen adult infratentorial gliomas were analyzed for chromosomal aberration by comparative genomic hybridization, and for expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry.
  • The most frequent chromosomal aberration was the gain of 7p, and five of the seven cerebellar or fourth ventricle malignant gliomas had that aberration.
  • However, the gain of 7q, the characteristic abnormality of supratentorial astrocytomas commonly associated with the gaining of 7p, was observed only in 1 of 11 adult infratentorial astrocytic tumors.
  • Our findings might suggest the presence of distinct tumorigenic pathway in adult infratentorial gliomas.
  • [MeSH-major] Brain Neoplasms / genetics. Frontal Lobe / pathology. Glioma / genetics. Receptor, Epidermal Growth Factor / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Chromosome Aberrations. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. Chromosomes, Human, Pair 7 / genetics. Comparative Genomic Hybridization. Female. Humans. Loss of Heterozygosity. Male. Middle Aged. Young Adult

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  • (PMID = 18941867.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Muscarella LA, Barbano R, Augello B, Formica V, Micale L, Zelante L, D'Agruma L, Merla G: An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma. J Hum Genet; 2007;52(6):485-91
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  • [Title] An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Cerebellar Neoplasms / genetics. Hemangioblastoma / genetics. Kidney Neoplasms / genetics. Promoter Regions, Genetic. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics
  • [MeSH-minor] Adult. Allelic Imbalance. Base Sequence. Electrophoretic Mobility Shift Assay. Humans. Male. Molecular Sequence Data. Mutation. Polymerase Chain Reaction


71. Merchant TE, Kun LE, Krasin MJ, Wallace D, Chintagumpala MM, Woo SY, Ashley DM, Sexton M, Kellie SJ, Ahern V, Gajjar A: Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. Int J Radiat Oncol Biol Phys; 2008 Mar 1;70(3):782-7
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  • The planning target volume for the primary site included the postoperative tumor bed surrounded by an anatomically confined margin of 2 cm that was then expanded with a geometric margin of 0.3-0.5 cm.

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  • (PMID = 17892918.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA021765-28; United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / CA21765; United States / NCI NIH HHS / CA / P30 CA021765-28
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ NIHMS40526; NLM/ PMC2716663
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72. Schumann M, Kiewe P, Hartlieb S, Neumann M, Schilling A, Koch HC, Thiel E, Korfel A: Diffuse leukoencephalopathy and brain edema: unusual presentations of CNS relapse of acute myeloid leukemia. J Neuroimaging; 2010 Apr;20(2):198-200
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  • Cerebral imaging revealed cerebral and cerebellar edema and a diffuse leukoencephalopathy.
  • The case highlights the relevance of the CNS as a pharmacologic "sanctuary" for tumor cells in patients that on prior treatments have not received intrathecal chemotherapy or chemotherapeutics that cross the blood-brain barrier.
  • [MeSH-minor] Adult. Humans. Male. Recurrence


73. Khan AO, Oystreck DT, Koenig M, Salih MA: Ophthalmic features of ataxia telangiectasia-like disorder. J AAPOS; 2008 Apr;12(2):186-9
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  • All patients had cerebellar atrophy by neuroimaging and slowly progressive ataxia.


74. Richter S, Schoch B, Kaiser O, Groetschel H, Dimitrova A, Hein-Kropp C, Maschke M, Gizewski ER, Timmann D: Behavioral and affective changes in children and adolescents with chronic cerebellar lesions. Neurosci Lett; 2005 Jun 10-17;381(1-2):102-7
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  • [Title] Behavioral and affective changes in children and adolescents with chronic cerebellar lesions.
  • The aim of the present study was to investigate if clinically relevant affective or behavioral changes as described in adults in the cerebellar affective syndrome by Schmahmann and Sherman [The cerebellar cognitive affective syndrome, Brain 121 (1998) 561-579] are likely to occur as a long-term sequelae of cerebellar vermis lesions in children.
  • Affect and behavior were assessed in children after cerebellar tumor surgery by means of experimenter ratings based on the description of the cerebellar affective syndrome and free ratings by the patients and their parents.
  • Twelve children and adolescents with a former cerebellar astrocytoma surgery without subsequent radiation or chemotherapy participated.
  • [MeSH-major] Cerebellar Diseases / complications. Cerebellar Diseases / diagnosis. Mental Disorders / diagnosis. Mental Disorders / etiology. Mood Disorders / diagnosis. Mood Disorders / etiology
  • [MeSH-minor] Adolescent. Adult. Child. Chronic Disease. Female. Humans. Male


75. Hamasaki K, Nakamura H, Ueda Y, Makino K, Kuratsu J: Radiation-induced glioblastoma occurring 35 years after radiation therapy for medulloblastoma: case report. Brain Tumor Pathol; 2010 Apr;27(1):39-43
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  • A 41-year-old man was admitted in June 2007 with a 1-month history of headache and cerebellar ataxia.
  • Cerebral angiographical study demonstrated vascular shift caused by a mass lesion in the cerebellar vermis.
  • The tumor was surgically removed, and he received radiotherapy and chemotherapy with ACNU, procarbazine, and vincristine.
  • Postoperative irradiation reduced the size of the second tumor.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Glioblastoma / etiology. Glioblastoma / therapy. Medulloblastoma / radiotherapy. Neoplasms, Second Primary. Radiotherapy / adverse effects
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Male. Neurosurgical Procedures. Nimustine / administration & dosage. Procarbazine / administration & dosage. Time Factors. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 20425047.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0S726V972K / Nimustine; 35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine
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76. Kinfe TM, Sedlaczek O, Blahak C, Bergler W, Wöhrle JC, Daffertshofer M, Bäzner H, Hennerici M, Krauss JK: Reconstruction of the petrosal bone for treatment of kinetic tremor due to cerebellar herniation and torsion of cerebellar outflow pathways. Mov Disord; 2008 Jul 30;23(10):1485-7
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  • [Title] Reconstruction of the petrosal bone for treatment of kinetic tremor due to cerebellar herniation and torsion of cerebellar outflow pathways.
  • [MeSH-major] Cerebellar Ataxia / surgery. Cerebellar Diseases / surgery. Encephalocele / surgery. Petrous Bone / surgery. Postoperative Complications / surgery. Prostheses and Implants. Torsion Abnormality / surgery. Tremor / surgery
  • [MeSH-minor] Abdominal Fat / transplantation. Adult. Efferent Pathways / physiopathology. Facial Paralysis / etiology. Gait Ataxia / etiology. Gait Ataxia / surgery. Glomus Jugulare Tumor / surgery. Hearing Loss, Mixed Conductive-Sensorineural / etiology. Humans. Male. Polymethyl Methacrylate. Pons / pathology. Recovery of Function. Transplantation, Autologous. Transplantation, Heterotopic

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  • (PMID = 18546298.001).
  • [ISSN] 1531-8257
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 9011-14-7 / Polymethyl Methacrylate
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77. Wang L, Lee KY, Park HT, Kang DS: Expression profile of tumor endothelial marker 7 and a putative ligand in the rat spinal cord and dorsal root ganglion. Asian Spine J; 2007 Dec;1(2):65-74
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  • [Title] Expression profile of tumor endothelial marker 7 and a putative ligand in the rat spinal cord and dorsal root ganglion.
  • STUDY DESIGN: To analyze the expression profile of tumor endothelial marker 7 (TEM7) in the spinal cord and dorsal root ganglion (DRG).
  • PURPOSE: To investigate the expression profile of TEM7 in the spinal cord and DRG of adult and developing rats.
  • OVERVIEW OF LITERATURE: Tumor endothelial marker 7 (TEM7) is a putative transmembrane protein that is highly expressed in the tumor endothelium and in cerebellar neurons.

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  • (PMID = 20411127.001).
  • [ISSN] 1976-7846
  • [Journal-full-title] Asian spine journal
  • [ISO-abbreviation] Asian Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2857480
  • [Keywords] NOTNLM ; Dorsal root ganglion / Ligand / Spinal cord / Tumor endothelial marker
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78. Adamson DC, Dimitrov DF, Bronec PR: Upward transtentorial herniation, hydrocephalus, and cerebellar edema in hypertensive encephalopathy. Neurologist; 2005 May;11(3):171-5
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  • [Title] Upward transtentorial herniation, hydrocephalus, and cerebellar edema in hypertensive encephalopathy.
  • BACKGROUND: Edema of the cerebellum with secondary obstructive hydrocephalus is a rare presentation of hypertensive encephalopathy.
  • Neuroimaging revealed edema of the cerebellar folia with noncommunicating hydrocephalus and upward transtentorial herniation.
  • Differential diagnoses of posterior fossa tumor, rhombencephalitis, and hypertensive encephalopathy were entertained.
  • Repeat imaging revealed near resolution of the obstructive hydrocephalus and cerebellar edema.
  • CONCLUSION: Isolated edema of the cerebellum with upward transtentorial herniation and obstructive hydrocephalus is a rare presentation of hypertensive encephalopathy and should be considered in patients with an acute hypertensive crisis and mental status changes.
  • [MeSH-major] Brain Edema / etiology. Cerebellar Diseases / etiology. Encephalocele / etiology. Hydrocephalus / etiology. Hypertensive Encephalopathy / complications
  • [MeSH-minor] Adult. Blood Pressure / physiology. Cranial Fossa, Posterior / pathology. Diuretics / administration & dosage. Diuretics / therapeutic use. Furosemide / administration & dosage. Furosemide / therapeutic use. Glasgow Coma Scale. Humans. Magnetic Resonance Imaging. Male. Neurodegenerative Diseases / etiology. Tomography, X-Ray Computed. Ventriculoperitoneal Shunt


79. Li XN, Shu Q, Su JM, Adesina AM, Wong KK, Perlaky L, Antalffy BA, Blaney SM, Lau CC: Differential expression of survivin splice isoforms in medulloblastomas. Neuropathol Appl Neurobiol; 2007 Feb;33(1):67-76
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  • The current study was undertaken to examine the mRNA expression of survivin isoforms and their correlation with clinical staging and outcome in 20 medulloblastoma (MB) tumours, three MB cell lines and normal brain tissues (a foetal and an adult cerebellum) by densitometry scanning of 32p-dCTP incorporated reverse transcription polymerase chain reaction (RT-PCR) products and quantitative real-time PCR.
  • Our results showed that the normal adult brain only expressed low levels of survivin-deltaEx3 mRNA, while the foetal brain expressed all three isoforms, with wild-type survivin as the dominant transcript.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. Microtubule-Associated Proteins / biosynthesis. Neoplasm Proteins / biosynthesis
  • [MeSH-minor] Adolescent. Cell Line, Tumor. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism. Humans. Immunohistochemistry. Infant. Inhibitor of Apoptosis Proteins. Isomerism. Male. Neoplasm Staging. RNA, Messenger / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Treatment Outcome

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  • (PMID = 17239009.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases
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80. Kaszper E, Hanzély Z, Szende B, Dabasi G, Garami M, Schuler D, Hauser P: [Examination of somatostatin receptor expression in recurrent childhood medulloblastomas]. Magy Onkol; 2008 Dec;52(4):351-5
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  • Medulloblastoma is the most common malignant pediatric central nervous system tumor.
  • Despite the adequate therapy the tumor often recurs.
  • The primary medulloblastoma expresses somatostatin receptor-2 (SSTR-2), but so far we had no experience about the receptor status in recurrent tumors.
  • All primary and recurrent tumors have been operated at the National Institute of Neurosurgery.
  • We examined the intensity and the percentage of SSTR-2-positive tumor cells in the primary and recurrent tumor samples.
  • All primary tumors were receptor-positive and SSTR-2 was also expressed in all recurrent medulloblastomas.
  • In our samples the percentage of SSTR-2-positive tumor cells was 30-90%.
  • As a conclusion, SSTR-2-positive recurrent tumors can be detected early by Octreoscan imaging, and the presence of SSTR-2 establishes the opportunity of applying somatostatin analogues (octreotide) in the treatment of recurrent childhood medulloblastoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cerebellar Neoplasms / chemistry. Medulloblastoma / chemistry. Neoplasm Recurrence, Local / chemistry. Receptors, Somatostatin / analysis
  • [MeSH-minor] Adolescent. Antineoplastic Agents, Hormonal / therapeutic use. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Indium Radioisotopes. Infant. Male. Octreotide / therapeutic use. Predictive Value of Tests. Somatostatin / analogs & derivatives. Tomography, Emission-Computed, Single-Photon / methods. Young Adult

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  • (PMID = 19068462.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers, Tumor; 0 / Indium Radioisotopes; 0 / Receptors, Somatostatin; 0 / somatostatin receptor 2; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide; RWM8CCW8GP / Octreotide
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81. Ju DT, Lin JW, Lin MS, Lee LM, Tseng HM, Wei CP, Yen CH, Hung CC, Hung KS, Lin CM, Lin TJ, Chiu WT, Tsai JT: Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. Acta Neurochir Suppl; 2008;101:169-73
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  • Tumors with volumes ranging from 0.13 to 24.8 cm3 (mean 5.4 cm3) were irradiated with the marginal dose 1800-2000 cGy/3 fractions.
  • Tumors were treated with an 80 to 89% isodose line (mean 83%) and mean 97.9% tumor coverage.
  • No facial or trigeminal dysfunction, brain stem toxicity, or cerebellar edema occurred.
  • Tumor regression was seen in 9 patients (43%) and stable in 12 patients (57%).
  • 100% tumor control rate was achieved.
  • Hypofractionated CKSRS was not only effective in tumor control but also excellent in hearing preservation for non-NF2 AN.
  • But for NF2 patients, although the tumor control was remarkable, hearing preservation was modest as in non-NF2 patients.
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Peripheral Nerves / physiopathology


82. Donovan DJ, Iskandar JI, Citrone MJ, Royer MC: Successful removal of a cerebellar hemangioblastoma in a combat support hospital. Mil Med; 2006 Mar;171(3):211-5
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  • [Title] Successful removal of a cerebellar hemangioblastoma in a combat support hospital.
  • Imaging studies revealed a cystic brain neoplasm causing hydrocephalus and increased intracranial pressure.
  • The tumor was completely removed and the patient's symptoms resolved, allowing safe evacuation.
  • This is the first reported case of a brain tumor successfully removed in a CSH.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Hospitals, Military. Hospitals, Packaged. Military Medicine. Military Personnel. Warfare
  • [MeSH-minor] Adult. Humans. Kuwait. Male. Tomography, X-Ray Computed. Treatment Outcome. United States

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  • (PMID = 16602518.001).
  • [ISSN] 0026-4075
  • [Journal-full-title] Military medicine
  • [ISO-abbreviation] Mil Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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83. Lueth M, von Deimling A, Pietsch T, Wong LJ, Kurtz A, Henze G, Driever PH: Medulloblastoma harbor somatic mitochondrial DNA mutations in the D-loop region. J Pediatr Hematol Oncol; 2010 Mar;32(2):156-9
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  • Despite the growing knowledge on molecular risk factors of the most common malignant brain tumor in childhood, medulloblastoma, its biology remains only partially understood.
  • A previous study investigating the entire mitochondrial genome of medulloblastoma revealed a number of somatic mutations in tumor and corresponding cerebrospinal fluid samples.
  • [MeSH-major] Cerebellar Neoplasms / genetics. DNA, Mitochondrial / genetics. Medulloblastoma / genetics. Mutation
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Genome, Mitochondrial. Humans. Infant. Male

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  • (PMID = 20147852.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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84. Gelabert González M: [Posterior fossa hemangioblastomas]. Neurologia; 2007 Dec;22(10):853-9
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  • INTRODUCTION: Hemangioblastomas are histologically benign lesions that comprise 1-2 % of primary nervous system tumours and 8-12 % of all posterior fossa lesions in the adult.
  • Tumors were located on cerebellar hemisphere (17), cerebellar vermis (4) and brain stem (1).
  • Tumors were cyst in 16 cases, solid in 8 cases.
  • Total tumor removal was achieved in 21 patients (95 %), and incomplete removal in 1 cases.
  • CONCLUSIONS: Hemangioblastomas are benign tumors of uncertain origin that are located predominantly in the posterior cranial fossa and the spinal cord.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Hemangioblastoma / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Cranial Fossa, Posterior. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17671853.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] Spain
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85. Imanaka M, Iida K, Takahashi K, Tsuji K, Nishizawa H, Fukuoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara K: The N131S mutation in the von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas. Endocr J; 2006 Dec;53(6):819-27
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  • von Hippel-Lindau (VHL) disease (VHLD) is a hereditary autosomal dominant syndrome that causes various benign and malignant tumors.
  • VHLD is caused by mutations in the VHL tumor suppressor gene.
  • We also identified somatic loss of heterozygosity (LOH) at chromosome 3p25-26 in the adrenal tumor of the patient.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Cerebellar Neoplasms / genetics. Hemangioblastoma / genetics. Mutation. Pheochromocytoma / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics
  • [MeSH-minor] Adult. Asian Continental Ancestry Group. DNA Mutational Analysis. Family. Humans. Male. Pedigree

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  • (PMID = 17001110.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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86. Van Diest D, De Raeve H, Claes J, Parizel PM, De Ridder D, Cras P: Paraneoplastic Opsoclonus-Myoclonus-Ataxia (OMA) syndrome in an adult patient with esthesioneuroblastoma. J Neurol; 2008 Apr;255(4):594-6
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  • [Title] Paraneoplastic Opsoclonus-Myoclonus-Ataxia (OMA) syndrome in an adult patient with esthesioneuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / complications. Esthesioneuroblastoma, Olfactory / pathology. Opsoclonus-Myoclonus Syndrome / etiology. Opsoclonus-Myoclonus Syndrome / immunology. Paranasal Sinus Neoplasms / complications. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cerebellar Ataxia / drug therapy. Cerebellar Ataxia / immunology. Cerebellar Ataxia / physiopathology. Cerebellum / drug effects. Cerebellum / immunology. Cerebellum / physiopathology. Disease Progression. Dose-Response Relationship, Drug. Ethmoid Sinus / immunology. Ethmoid Sinus / pathology. Female. Humans. Immunosuppressive Agents / administration & dosage. Methylprednisolone / administration & dosage. Middle Aged. Nasal Septum / immunology. Nasal Septum / pathology. Oculomotor Muscles / drug effects. Oculomotor Muscles / immunology. Oculomotor Muscles / physiopathology. Remission Induction. Skin Neoplasms / secondary. Skin Neoplasms / surgery. Treatment Outcome


87. Tella OI, Stavale JN, Herculano MA, Paiva Neto MA, Onishi FJ, Guimarães Filho Fde A, Silva LR: [Size and proliferative index correlation in acoustic neuromas]. Arq Neuropsiquiatr; 2006 Mar;64(1):72-6
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  • Acoustic neuromas are the most common tumors in the cerebellopontine angle.
  • The molecular mechanisms involved in generation and growth of these tumors are not completely elucidated.
  • Many radiological, clinic and immunohistochemistry data were correlated to tumor growth.
  • The size of the tumors were positively correlationated with proliferative index.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Ki-67 Antigen / analysis. Neoplasm Proteins / analysis. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Age Distribution. Age Factors. Aged. Cell Proliferation. Cell Size. Female. Humans. Immunohistochemistry. Middle Aged. Mitotic Index. Neoplasm Invasiveness. Statistics, Nonparametric

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  • (PMID = 16622557.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins
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88. Chen YT, Collins LL, Chang SS, Chang C: The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development. Cerebellum; 2008;7(1):9-17
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  • [Title] The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development.
  • Throughout postnatal and adult stages, TR4(-/-) mice exhibited behavioral deficits in motor coordination, suggesting impaired cerebellar function.
  • Histological examination of the postnatal and adult TR4(-/-) cerebellum revealed gross abnormalities in foliation.
  • Further analyses demonstrated changes in the lamination of the TR4(-/-) cerebellar cortex, including reduction in the thickness of both the molecular layer (ML) and the internal granule layer (IGL).
  • Analyses of the developing TR4(-/-) cerebellum indicate that the lamination irregularities observed may result from disrupted granule cell proliferation within the external granule cell layer (EGL), delayed inward migration of post-mitotic granule cells, and increased apoptosis during cerebellar development.
  • In addition, abnormal development of Purkinje cells was observed in the postnatal TR4(-/-) cerebellum, as indicated by aberrant dendritic arborization.
  • In postnatal, neuronal-specific TR4 knockout mice, architectural changes in the cerebellum were similar to those seen in TR4(-/-) animals, suggesting that TR4 function in neuronal lineages might be important for cerebellar morphogenesis, and that the effect on Purkinje cell development is likely mediated by changes elsewhere, such as in granule cells, or is highly dependent on developmental stage.
  • Together, our findings from various TR4 knockout mouse models suggest that TR4 is required for normal cerebellar development and that failure to establish proper cytoarchitecture results in dysfunction of the cerebellum and leads to abnormal behavior.
  • [MeSH-major] Cerebellar Cortex / physiology. Receptors, Steroid / physiology. Receptors, Thyroid Hormone / physiology

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  • (PMID = 18418664.001).
  • [ISSN] 1473-4230
  • [Journal-full-title] Cerebellum (London, England)
  • [ISO-abbreviation] Cerebellum
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 56984; United States / NIDDK NIH HHS / DK / DK 63212
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nr2c2 protein, mouse; 0 / Receptors, Steroid; 0 / Receptors, Thyroid Hormone; 56-12-2 / gamma-Aminobutyric Acid
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89. Gheri CF, Buccoliero AM, Pansini G, Castiglione F, Garbini F, Moncini D, Maccari C, Mennonna P, Pellicanò G, Ammannati F, Taddei GL: Lipoastrocytoma: Case report and review of the literature. Neuropathology; 2010 Oct;30(5):553-8
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  • Lipoastrocytoma is an extremely rare tumor, with only six cases described.
  • We report the case of an astrocytoma involving the upper part of the cerebellar-pontine angle and the right portion of the clivus starting from the brainstem with a diffuse lipomatous component in a 39 year-old man.
  • MRI revealed a ponto-cerebellar lesion that showed irregular enhancement after contrast administration.
  • Subtotal excision of the tumor was accomplished.
  • Histologically the tumor showed the classical histology of low-grade astrocytoma and a portion of the lesion was composed of lipid-laden cells.
  • It is important to record each new case of this rare tumor to produce a better characterization of this lesion.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Lipomatosis / pathology
  • [MeSH-minor] Adult. Brain Stem / pathology. Cerebellum / pathology. Humans. Male

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  • [Copyright] © 2010 Japanese Society of Neuropathology.
  • (PMID = 20113404.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Keywords] NOTNLM ; lipid vacuole / lipoastrocytoma / lipomatous / low grade astrocytoma
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90. Gokcan MK, Batikhan H, Calguner M, Tataragasi AI: Unilateral hearing loss as a presenting manifestation of granulocytic sarcoma (chloroma). Otol Neurotol; 2006 Jan;27(1):106-9
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  • As increased intracranial pressure symptoms developed subsequently, subtotal tumor resection was performed.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Hearing Loss, Sudden / etiology. Sarcoma, Myeloid / complications. Sarcoma, Myeloid / diagnosis
  • [MeSH-minor] Adult. Auditory Threshold. Evoked Potentials, Auditory, Brain Stem / physiology. Facial Paralysis / etiology. Female. Humans. Leukemia, Promyelocytic, Acute / complications. Leukemia, Promyelocytic, Acute / therapy. Magnetic Resonance Imaging. Treatment Outcome. Vocal Cord Paralysis / etiology

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  • (PMID = 16371856.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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91. Morawski KF, Niemczyk K, Bohorquez J, Marchel A, Delgado RE, Ozdamar O, Telischi FF: Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography. Otol Neurotol; 2007 Jun;28(4):541-5
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  • [Title] Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography.
  • PATIENTS: Fifteen patients with cerebellopontine angle tumor among 50 patients were included in this study.

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  • (PMID = 17529854.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC004344-02; United States / NIDCD NIH HHS / DC / R44 DC004344; United States / NIDCD NIH HHS / DC / 2R44DC04344-02; United States / NIDCD NIH HHS / DC / R44 DC004344-02
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS27764; NLM/ PMC2094124
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92. Nordfors K, Haapasalo J, Korja M, Niemelä A, Laine J, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S, Haapasalo H: The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis. BMC Cancer; 2010;10:148
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  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Carbonic Anhydrase II / analysis. Carbonic Anhydrases / analysis. Cerebellar Neoplasms / enzymology. Medulloblastoma / enzymology. Neuroectodermal Tumors, Primitive / enzymology. Supratentorial Neoplasms / enzymology
  • [MeSH-minor] Adolescent. Adult. Aged. Apoptosis. Chi-Square Distribution. Child. Child, Preschool. Cytoplasm / enzymology. Endothelial Cells / enzymology. Female. Finland. Humans. Immunohistochemistry. Infant. Infant, Newborn. Kaplan-Meier Estimate. Male. Middle Aged. Odds Ratio. Proportional Hazards Models. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20398423.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; EC 4.2.1.1 / carbonic anhydrase XII
  • [Other-IDs] NLM/ PMC2874782
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93. Brackmann DE, Doherty JK: CPA melanoma: diagnosis and management. Otol Neurotol; 2007 Jun;28(4):529-37
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  • Translabyrinthine craniotomy was performed for tumor extirpation in five patients.
  • MAIN OUTCOME MEASURE(S): Symptoms at presentation, MRI findings, presence of malignant cells in CSF, tumor progression, intraoperative findings, response to treatment, time interval from initial diagnosis of melanoma elsewhere, and survival.
  • Management includes tumor resection when melanoma seems to be solitary and malignant cells are not present in CSF.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / therapy. Cerebellopontine Angle. Melanoma / diagnosis. Melanoma / therapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Facial Paralysis / etiology. Fatal Outcome. Female. Hearing Loss, Bilateral / etiology. Humans. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Retrospective Studies

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  • (PMID = 17414177.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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94. Shah MN, Leonard JR, Perry A: Rosette-forming glioneuronal tumors of the posterior fossa. J Neurosurg Pediatr; 2010 Jan;5(1):98-103
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  • [Title] Rosette-forming glioneuronal tumors of the posterior fossa.
  • Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare, recently described WHO Grade I neoplasm.
  • The authors report 6 examples of RGNT arising primarily from the cerebellar vermis.
  • The original diagnoses included pilocytic astrocytoma, ependymoma, cerebellar dysembryoplastic neuroepithelial tumor (DNT), and oligodendroglioma.
  • These cases expand the known clinical and histological spectrum of this rare tumor type.
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / surgery. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / surgery. Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Cranial Fossa, Posterior. Ependymoma / diagnosis. Ependymoma / surgery. Magnetic Resonance Imaging. Neuroectodermal Tumors, Primitive / diagnosis. Oligodendroglioma / diagnosis. Oligodendroglioma / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / surgery. Teratoma / diagnosis. Teratoma / surgery
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Female. Humans. Middle Aged

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  • (PMID = 20043744.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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95. Tailor JK, Kim AH, Folkerth RD, Black PM: The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report. Neurosurgery; 2008 Sep;63(3):E609-10; discussion E610
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  • [Title] The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report.
  • OBJECTIVE: Dysembryoplastic neuroepithelial tumor (DNT) occurs rarely in the cerebellum.
  • We describe a rare case of cerebellar DNT that developed contrast enhancement after long-term observation and discuss the underlying mechanism and clinical relevance of this unusual phenomenon.
  • CLINICAL PRESENTATION: A 34-year-old woman with known cystic cerebellar lesions presented with increased frequency of vertigo and new onset of truncal ataxia.
  • Magnetic resonance imaging revealed new contrast enhancement in the dominant cystic lesion of the cerebellar vermis without any change in size and shape or evidence of edema.
  • CONCLUSION: This is the first report of the development of contrast enhancement in a previously nonenhancing case of cerebellar DNT.
  • [MeSH-major] Cerebellar Neoplasms / radiography. Contrast Media. Neoplasms, Neuroepithelial / radiography. Teratoma / radiography
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Magnetic Resonance Imaging / trends

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  • (PMID = 18812941.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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96. Zhang HZ, Lan Q: Design and microsurgical anatomy of the retrosigmoid-retrocondylar keyhole approach without occipital condyle removal. Minim Invasive Neurosurg; 2006 Feb;49(1):49-54
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  • METHODS: 8 adult cadaveric heads fixed in formalin and with intracranial vessels perfused by colored latex were used in this study.
  • Many anatomic structures could be observed under the microscope when the cerebellar hemisphere was retracted.
  • By means of adjusting the head position and the angle of microscope, the ipsilateral vertebral artery, posterior inferior cerebellar artery, anterior inferior cerebellar artery, VII, VIII, IX, X, XI, XII cranial nerves and the ventral lateral aspect of medulla oblongata were exposed via this keyhole approach.
  • With the techniques of modern microsurgery, several diseases such as an aneurysm situated at the vertebral artery or the posterior inferior cerebellar artery, a small hypoglossal neurinoma and tumor located at the ventral lateral aspect of the medulla oblongata, may be operated via this retrosigmoid-retrocondylar keyhole approach without drilling the occipital condyle.
  • [MeSH-minor] Adult. Cadaver. Cranial Nerves / anatomy & histology. Dissection. Feasibility Studies. Humans. Medulla Oblongata / anatomy & histology. Vertebral Artery / anatomy & histology

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  • (PMID = 16547883.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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97. Mattos JP, Marenco HA, Campos JM, Faria AV, Queiroz LS, Borges G, Oliveira Ed: Cerebellar glioblastoma multiforme in an adult. Arq Neuropsiquiatr; 2006 Mar;64(1):132-5
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  • [Title] Cerebellar glioblastoma multiforme in an adult.
  • Cerebellar glioblastoma multiforme (GBM) is a rare tumor.
  • In conjunction, we present a literature review including particular issues, clinical data, advances in imaging studies, pathological characteristics, treatment options and the behavior of such malignant tumor.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellum / pathology. Glioblastoma / pathology

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  • (PMID = 16622570.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 16
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98. Ito-Ishida A, Miura E, Emi K, Matsuda K, Iijima T, Kondo T, Kohda K, Watanabe M, Yuzaki M: Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo. J Neurosci; 2008 Jun 4;28(23):5920-30
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  • [Title] Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo.
  • Cbln1, which belongs to the C1q/tumor necrosis factor superfamily, is the most recently identified protein involved in synapse formation in the mammalian CNS.
  • In the cerebellum, Cbln1 is predominantly produced and secreted from granule cells; cbln1-null mice show ataxia and a severe reduction in the number of synapses between Purkinje cells and parallel fibers (PFs), the axon bundle of granule cells.
  • Cbln1 also rapidly induced electrophysiologically functional and ultrastructurally normal PF synapses in acutely prepared cbln1-null cerebellar slices.
  • Furthermore, a single injection of recombinant Cbln1 rescued severe ataxia in adult cbln1-null mice in vivo by completely, but transiently, restoring PF synapses.
  • Therefore, Cbln1 is a unique synapse organizer that is required not only for the normal development of PF-Purkinje cell synapses but also for their maintenance in the mature cerebellum both in vitro and in vivo.
  • Furthermore, our results indicate that Cbln1 can also rapidly organize new synapses in adult cerebellum, implying its therapeutic potential for cerebellar ataxic disorders.
  • [MeSH-minor] Age Factors. Animals. Cell Line. Cells, Cultured. Cerebellum / growth & development. Cerebellum / ultrastructure. Mice. Mice, Knockout

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  • (PMID = 18524896.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cbln1 protein, mouse; 0 / Nerve Tissue Proteins; 0 / Protein Precursors
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99. Attard TM, Giglio P, Koppula S, Snyder C, Lynch HT: Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. Cancer; 2007 Feb 15;109(4):761-6
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  • [Title] Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis.
  • They are at an increased risk of brain tumors, including cerebellar medulloblastoma, when compared with the general population (Brain Tumor Polyposis-BTP Type 2).
  • Genotype-phenotype correlations between APC gene mutations and central nervous system (CNS) tumors have, thus far not been successful.
  • METHODS: The authors analyzed their established hereditary CRC Registry for brain tumors in FAP pedigrees (56 families, 213 individuals), pooled their patients with BTP and known APC mutations with those reported thus far elsewhere, and compared the resulting mutation distribution of FAP-BTP with the mutation distribution for APC mutations in the US.
  • RESULTS: Twenty-eight patients from 24 families were accrued, the most common brain tumor in BTP was medulloblastoma (60%) predominantly in females (12:5) under the age of 20 (mean age 14.7 SD 9.2).
  • Analysis of the pooled APC mutation data by Chi-square test of association shows an odds ratio of 3.7 (P < .005) for all brain tumor subtypes and 13.1 (P < .001) for medulloblastoma in patients harboring segment 2 APC mutation (codons 679-1224) compared to nonsegment 2 mutation.
  • CONCLUSIONS: In patients with FAP and identifiable APC gene mutation, CNS tumors, especially medulloblastoma which developed in most cases during childhood, are more common in females with FAP and APC gene mutation in codons 686-1217.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli Protein / genetics. Brain Neoplasms / complications. Mutation / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Codon. Female. Humans. Male. Pedigree. Registries


100. Rivera AL, Takei H, Zhai J, Shen SS, Ro JY, Powell SZ: Useful immunohistochemical markers in differentiating hemangioblastoma versus metastatic renal cell carcinoma. Neuropathology; 2010 Dec;30(6):580-5
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  • Hemangioblastomas (HBs) account for nearly a tenth of all posterior fossa neoplasms and can be the presenting finding in patients with von Hippel-Lindau (VHL) syndrome.
  • Fifteen cerebellar HBs and 17 metastatic clear cell RCCs to the brain were selected for the study.
  • The staining patterns were scored based on intensity and extent of tumor staining.
  • Fli-1 failed to stain tumor cells in both HBs and RCC.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Cerebellar Neoplasms / diagnosis. Hemangioblastoma / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • [Copyright] © 2010 Japanese Society of Neuropathology.
  • (PMID = 20374497.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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