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6. Alcantara MP, Lazarini PR, Veiga JC, Barboza ES, Lancellotti CL: Cerebellopontine angle cavernous hemangioma. Braz J Otorhinolaryngol; 2006 Nov-Dec;72(6):850
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  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Ear Neoplasms / diagnosis. Hemangioma, Cavernous / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Cerebellopontine Angle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17308842.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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7. Curry WT Jr, Cosgrove GR, Hochberg FH, Loeffler J, Zervas NT: Stereotactic interstitial radiosurgery for cerebral metastases. J Neurosurg; 2005 Oct;103(4):630-5
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  • OBJECT: The Photon Radiosurgery System (PRS) is a miniature x-ray generator that can stereotactically irradiate intracranial tumors by using low-energy photons.
  • Local control of lesions was defined as either stabilization or diminution in the size of the treated tumor as confirmed by Gd-enhanced magnetic resonance imaging.
  • Primary tumors included lung (33 patients), melanoma (15 patients), renal cell (five patients), breast (two patients), esophageal (two patients), colon (one patient), and Merkle cell (one patient) cancers, and malignant fibrous histiocytoma (one patient).
  • Supratentorial metastases were distributed throughout the cerebrum, with only one cerebellar metastasis.
  • At the last follow-up examination (median 6 months), local disease control had been achieved in 48 (81%) of 59 tumors.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Radiosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brachytherapy. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 16266044.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD: The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res; 2009 Apr 15;69(8):3249-55
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  • [Title] The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.
  • Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood.
  • Consistent with its regulation by Shh, we observed that Shh treatment of primary cerebellar granule neuron precursors (CGNP), proposed cells of origin for the Shh-associated medulloblastomas, resulted in increased miR-17/92 expression.

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  • (PMID = 19351822.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS061070-01; United States / NINDS NIH HHS / NS / R01 NS061070; United States / NINDS NIH HHS / NS / R01 NS061070-01; United States / NINDS NIH HHS / NS / R01NS061070
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / MIRN17 microRNA, human; 0 / MicroRNAs; 0 / Proto-Oncogene Proteins c-myc; 0 / SHH protein, human
  • [Other-IDs] NLM/ NIHMS100132; NLM/ PMC2836891
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9. Sander T, Sprenger A, Neumann G, Machner B, Gottschalk S, Rambold H, Helmchen C: Vergence deficits in patients with cerebellar lesions. Brain; 2009 Jan;132(Pt 1):103-15
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  • [Title] Vergence deficits in patients with cerebellar lesions.
  • The cerebellum is part of the cortico-ponto-cerebellar circuit for conjugate eye movements.
  • Recent animal data suggest an additional role of the cerebellum for the control of binocular alignment and disconjugate, i.e. vergence eye movements.
  • The aim of this study was to investigate whether circumscribed cerebellar lesions affect these dynamic vergence eye movements.
  • Disconjugate fast and slow vergence, conjugate smooth pursuit and saccades were binocularly recorded by a scleral search coil system in 20 patients with acute cerebellar lesions (all ischemic strokes except for one) and 20 age-matched healthy controls.
  • We conclude that (i) the human cerebellum, in particular the vermis, is involved in the processing of dynamic vergence eye movements and (ii) cerebellar lesions elicit dissociable effects on fast and slow vergence.
  • [MeSH-major] Cerebellum / blood supply. Cerebral Infarction / complications. Ocular Motility Disorders / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brain Mapping / methods. Cerebellar Neoplasms / complications. Convergence, Ocular. Eye Movement Measurements. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Pursuit, Smooth. Saccades


10. Castillo CG, Correa OC, Aguilar FA, García-Cayuela J, Navarro N, Alvarez JA: [Epidural anesthesia for cesarean section in a patient with von Hippel-Lindau disease]. Rev Esp Anestesiol Reanim; 2010 Jun-Jul;57(6):381-4
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  • It is characterized by hemangioblastomas in multiple organs but mainly in the retina and cerebellum.
  • She had no neurologic symptoms at the time of the operation but a history of ocular and cerebellar involvement and several procedures to remove cerebellar hemangioblastomas.
  • [MeSH-minor] Adult. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / surgery. Diabetes, Gestational. Female. Hemangioblastoma / genetics. Hemangioblastoma / surgery. Hemangioma / genetics. Hemangioma / surgery. Humans. Infant, Newborn. Laser Coagulation. Male. Pregnancy. Radiosurgery. Reoperation. Retinal Neoplasms / genetics. Retinal Neoplasms / surgery. Survivors

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  • (PMID = 20645491.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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11. Dubey A, Sung WS, Shaya M, Patwardhan R, Willis B, Smith D, Nanda A: Complications of posterior cranial fossa surgery--an institutional experience of 500 patients. Surg Neurol; 2009 Oct;72(4):369-75
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  • (1) cerebellopontine angle lesion, (2) microvascular decompression for facial pain and spasm, (3) cerebellar lesions, (4) Chiari I decompression, and (5) petroclival lesions.
  • RESULTS: Of the 500 patients reviewed, 220 (44%) patients had tumor resections at the cerebellopontine angle; 110 (22%) patients had microvascular decompression for trigeminal neuralgia and hemifacial spasm; 86 (17.2%) patients had cerebellar lesions; 60 (12%) patients had Chiari I decompression; and 24 (4.8%) patients required transpetrosal approaches for petroclival lesions.
  • Other complications that were observed to develop almost exclusively in patients undergoing cerebellar parenchymal tumor resection included cerebellar edema in 25 (5%) patients, hydrocephalus in 23 (4.6%) patients, cerebellar hematoma in 15 (3%) patients, and cerebellar mutism in 6 (1.2%) patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Arnold-Chiari Malformation / pathology. Arnold-Chiari Malformation / surgery. Brain Neoplasms / pathology. Brain Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Child. Chordoma / pathology. Chordoma / surgery. Decompression, Surgical / adverse effects. Decompression, Surgical / methods. Female. Hemifacial Spasm / pathology. Hemifacial Spasm / surgery. Humans. Length of Stay. Male. Microsurgery / adverse effects. Microsurgery / methods. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 19604553.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Bonneville F, Savatovsky J, Chiras J: Imaging of cerebellopontine angle lesions: an update. Part 1: enhancing extra-axial lesions. Eur Radiol; 2007 Oct;17(10):2472-82
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  • [MeSH-major] Cerebellar Diseases / diagnosis. Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurilemmoma / diagnosis

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  • (PMID = 17562049.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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13. Capper D, Mittelbronn M, Goeppert B, Meyermann R, Schittenhelm J: Secreted protein, acidic and rich in cysteine (SPARC) expression in astrocytic tumour cells negatively correlates with proliferation, while vascular SPARC expression is associated with patient survival. Neuropathol Appl Neurobiol; 2010 Apr;36(3):183-97
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  • RESULTS: In normal brain, SPARC is expressed in cortical marginal glia, cerebellar Bergmann glia and focally in white matter but is absent in neurones or vessels.
  • [MeSH-major] Astrocytoma / metabolism. Blood Vessels / metabolism. Brain / metabolism. Brain Neoplasms / metabolism. Cell Proliferation. Osteonectin / metabolism
  • [MeSH-minor] Adult. Cell Movement. Cytoplasm / metabolism. Cytoplasm / pathology. Female. Glioblastoma / blood supply. Glioblastoma / metabolism. Glioblastoma / mortality. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neovascularization, Pathologic. Nerve Fibers, Myelinated / metabolism. Nerve Fibers, Myelinated / pathology. Neuroglia / metabolism. Neuroglia / pathology. Neurons / metabolism. Neurons / pathology. RNA, Messenger / metabolism. Young Adult

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  • (PMID = 20132490.001).
  • [ISSN] 1365-2990
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Osteonectin; 0 / RNA, Messenger
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1
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4. Sun YJ, Yu SZ, Sun CY, Wang Q, Jin SM, Wu WX, An TL: [Detection of chromosomal DNA imbalance in medulloblastoma by comparative genomic hybridization]. Zhonghua Bing Li Xue Za Zhi; 2010 Sep;39(9):606-10
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  • Eleven gain zones (+5q, +6q, +7q, +11q, +15q, +17p, +17q, +19q, +20q, +21q, +Xp) and twenty-five loss zones (-1p, -1q, -2p, -2q, -3q, -4p, -6p, -6q, -8p, -8q, -10p, -10q, -11p, -14q, -16p, -16q, -17p, -18p, -18q, -19p, -19q, -20p, -20q, -Xp, -Xq) were detected in those tumors.
  • +7q, +17q, -14q and -10q correlate closely to development of the tumors.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Chromosome Deletion. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Comparative Genomic Hybridization. DNA, Neoplasm / genetics. Female. Humans. Male. Sex Factors. Young Adult

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  • (PMID = 21092588.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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15. Crabtree KL, Arnold PM: Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously. Pediatr Neurosurg; 2010;46(1):66-70
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  • [Title] Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously.
  • We report a 26-year-old male with an intradural extramedullary PA at the thoracolumbar junction following subtotal cerebellar PA resection 18 years previously.
  • To our knowledge, this is the longest time reported from initial tumor resection of leptomeningeal dissemination to the distal spinal cord.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Meningeal Neoplasms / secondary. Neoplasm Seeding. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Child. Follow-Up Studies. Humans. Laminectomy. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Thoracic Vertebrae. Time Factors

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516744.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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16. Chelly I, Mekni A, Kchir N, Karim BH, Khadija B, Selma B, Slim H, Khaldi M, Zitouna M: Intracerebellar granulocytic sarcoma. A case report. Pathologica; 2005 Oct;97(5):335-7
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  • We report a case of cerebellar granulocytic sarcoma occuring in a 43 years old woman without any precedent medical history.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Sarcoma, Myeloid / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Carboxylic Ester Hydrolases / analysis. Fatal Outcome. Female. Headache / etiology. Hepatomegaly / etiology. Humans. Immunoenzyme Techniques. Muramidase / analysis. Neoplasm Proteins / analysis. Peroxidase / analysis. Splenomegaly / etiology. Staining and Labeling

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  • (PMID = 16480032.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / Neoplasm Proteins; EC 1.11.1.7 / Peroxidase; EC 3.1.1.- / Carboxylic Ester Hydrolases; EC 3.1.1.- / chloroacetate esterase; EC 3.2.1.17 / Muramidase
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17. Kohout A: [Nervous component of mature cystic ovarian teratomas]. Cesk Patol; 2005 Jan;41(1):19-28
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  • Apart from the foci similar to grey matter of the spinal cord and cerebral cortex, those of differentiated cerebellar cortex were present as well.
  • Ultrastructurally, neurons with fully developed synapses were observed in the nervous component, and dendritic spines were present on dendrites of Purkinje cells of cerebellar cortex.
  • [MeSH-major] Nerve Tissue / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Middle Aged

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  • (PMID = 15816120.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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18. Furuse M, Miyatake SI, Kuroiwa T: Cavernous malformation after radiation therapy for astrocytoma in adult patients: report of 2 cases. Acta Neurochir (Wien); 2005 Oct;147(10):1097-101; discussion 1101
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  • [Title] Cavernous malformation after radiation therapy for astrocytoma in adult patients: report of 2 cases.
  • We describe two adult patients with cavernous malformation after irradiation for astrocytoma.
  • Radiation-induced cavernous malformations are rare in adult patients with astrocytoma.
  • [MeSH-major] Astrocytoma / radiotherapy. Blood Vessels / pathology. Blood Vessels / radiation effects. Brain Neoplasms / radiotherapy. Hemangioma, Cavernous, Central Nervous System / etiology. Neoplasms, Radiation-Induced / etiology. Radiotherapy / adverse effects
  • [MeSH-minor] Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / radiotherapy. Dementia / diagnosis. Dementia / etiology. Dementia / physiopathology. Frontal Lobe / blood supply. Frontal Lobe / pathology. Frontal Lobe / radiation effects. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Temporal Lobe / blood supply. Temporal Lobe / pathology. Temporal Lobe / radiation effects. Tomography, X-Ray Computed

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  • (PMID = 16021386.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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19. McCarthy T, Leighton R, Mushambi M: Spinal anaesthesia for caesarean section for a woman with von Hippel Lindau disease. Int J Obstet Anesth; 2010 Oct;19(4):461-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Cerebellar Neoplasms / pathology. Female. Hemangioblastoma / pathology. Humans. Magnetic Resonance Imaging. Pregnancy. Spinal Cord Neoplasms / pathology

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  • [CommentOn] Int J Obstet Anesth. 2009 Jul;18(3):294-5 [19447600.001]
  • (PMID = 20692826.001).
  • [ISSN] 1532-3374
  • [Journal-full-title] International journal of obstetric anesthesia
  • [ISO-abbreviation] Int J Obstet Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Netherlands
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20. Puget S, Rutka JT: Malignant brain tumors: two steps forward. Clin Neurosurg; 2007;54:4-9
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  • [Title] Malignant brain tumors: two steps forward.
  • [MeSH-major] Brain Neoplasms / surgery. Glioma / surgery. Neurosurgical Procedures / trends
  • [MeSH-minor] Adult. Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / surgery. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Disease Progression. Female. Forecasting. Gene Expression Profiling. Humans. Male. Medulloblastoma / drug therapy. Medulloblastoma / genetics. Medulloblastoma / surgery. Oligodendroglioma / drug therapy. Oligodendroglioma / genetics. Oligodendroglioma / surgery. Oligonucleotide Array Sequence Analysis

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  • (PMID = 18504889.001).
  • [ISSN] 0069-4827
  • [Journal-full-title] Clinical neurosurgery
  • [ISO-abbreviation] Clin Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Jalali R, Mallick I, Dutta D, Goswami S, Gupta T, Munshi A, Deshpande D, Sarin R: Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):974-9
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  • [Title] Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy.
  • PURPOSE: To present the effect of radiotherapy doses to different volumes of normal structures on neurocognitive outcomes in young patients with benign and low-grade brain tumors treated prospectively with stereotactic conformal radiotherapy (SCRT).
  • METHODS AND MATERIALS: Twenty-eight patients (median age, 13 years) with residual/progressive brain tumors (10 craniopharyngioma, 8 cerebellar astrocytoma, 6 optic pathway glioma and 4 cerebral low-grade glioma) were treated with SCRT to a dose of 54 Gy in 30 fractions over 6 weeks.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Cognition Disorders / etiology. Glioma / radiotherapy. Intelligence / radiation effects
  • [MeSH-minor] Adolescent. Astrocytoma / radiotherapy. Cerebellar Neoplasms / psychology. Cerebellar Neoplasms / radiotherapy. Child. Cognition / radiation effects. Craniopharyngioma / psychology. Craniopharyngioma / radiotherapy. Female. Humans. Male. Optic Nerve Glioma / radiotherapy. Prospective Studies. Radiotherapy, Conformal / methods. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19864079.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Lindsey JC, Lusher ME, Anderton JA, Gilbertson RJ, Ellison DW, Clifford SC: Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma. Br J Cancer; 2007 Jul 16;97(2):267-74
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  • Assessment of these genes in the non-neoplastic cerebellum (from which medulloblastomas develop) revealed strong somatic methylation affecting S100A2 and S100A4, whereas S100A6 and S100A10 were unmethylated.
  • In contrast, pro-metastatic S100A4 displayed evidence of hypomethylation relative to the normal cerebellum in a significant proportion primary tumours (7 out of 41, 17%) and cell lines (3 out of 9, 33%), which was associated with its elevated expression.
  • In summary, these data characterise complex patterns of somatic methylation affecting S100 genes in the normal cerebellum and demonstrate their disruption causing epigenetic deregulation of multiple S100 family members in medulloblastoma development.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Epigenesis, Genetic. Gene Expression Regulation, Neoplastic. Medulloblastoma / genetics. S100 Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Azacitidine / analogs & derivatives. Azacitidine / pharmacology. Cell Line, Tumor. Cerebellum / metabolism. Child. Child, Preschool. DNA Methylation. DNA Modification Methylases / antagonists & inhibitors. Female. Humans. Infant. Male

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  • (PMID = 17579622.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / S100 Proteins; 776B62CQ27 / decitabine; EC 2.1.1.- / DNA Modification Methylases; M801H13NRU / Azacitidine
  • [Other-IDs] NLM/ PMC2360310
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23. Ganeshan D, Anand D: Radiological reasoning: cerebellopontine mass causing hemifacial spasm. AJR Am J Roentgenol; 2010 Sep;195(3 Suppl):S12-4 (Quiz S15-21)
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  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellar Neoplasms / diagnosis. Hemifacial Spasm / etiology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adult. Cerebellopontine Angle / pathology. Contrast Media. Diagnosis, Differential. Female. Humans

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  • (PMID = 20729405.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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24. Peltier J, Lok C, Fichten A, Bruniau A, Lefranc M, Toussaint P, Desenclos C, Le Gars D: Lhermitte-Duclos disease and Cowden's syndrome. Report of two cases. Neurochirurgie; 2006 Nov;52(5):407-14
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  • OBJECTIVE AND IMPORTANCE: Lhermitte-Duclos disease, or dysplastic cerebellar gangliocytoma is a rare entity characterized by a hamartomatous lesion in the posterior fossa.
  • Cowden's syndrome, or hamartoma-neoplasia syndrome is a rare underdiagnosed autosomal dominant genodermatosis with high incidence of malignant tumors.
  • CLINICAL PRESENTATION: We report two cases of Lhermitte-Duclos and Cowden disease occurring in adult patients.
  • An asymptomatic 38-year-old male had bilateral optic nerve drusen related to a cerebellar neoplasm.
  • A conservative strategy can be chosen without neurological signs because of slow tumor growth.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Ganglioneuroma / pathology. Ganglioneuroma / surgery. Hamartoma Syndrome, Multiple / pathology. Hamartoma Syndrome, Multiple / surgery
  • [MeSH-minor] Adult. Female. Fibrocystic Breast Disease / etiology. Fibrocystic Breast Disease / physiopathology. Goiter / complications. Humans. Intracranial Hypertension / etiology. Intracranial Hypertension / physiopathology. Magnetic Resonance Imaging. Male. Neurocutaneous Syndromes / pathology. Pedigree. Syndrome

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  • (PMID = 17185946.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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25. Brandes AA, Franceschi E, Tosoni A, Blatt V, Ermani M: Long-term results of a prospective study on the treatment of medulloblastoma in adults. Cancer; 2007 Nov 1;110(9):2035-41
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  • CONCLUSIONS: In adult patients with MB, long-term follow-up was essential for evaluating the real impact of treatments.
  • [MeSH-major] Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prospective Studies. Radiotherapy. Survival Rate. Time. Treatment Outcome

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  • (PMID = 17823910.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
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26. Miyazawa T, Aida S, Shima K: Hemorrhagic cerebellar anaplastic glioma appearing 12 years after prophylactic cranial radiotherapy for acute lymphocytic leukemia. Neurol Med Chir (Tokyo); 2008 Mar;48(3):126-30
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  • [Title] Hemorrhagic cerebellar anaplastic glioma appearing 12 years after prophylactic cranial radiotherapy for acute lymphocytic leukemia.
  • A radiation-induced cerebellar glioma is extremely rare, and the etiology of such a tumor is unknown.
  • We report a rare case of hemorrhagic cerebellar anaplastic glioma occurring 12 years after prophylactic cranial radiotherapy for acute lymphocytic leukemia.
  • We discuss the etiologies of the radiation-induced hemorrhagic cerebellar glioma as a secondary malignancy after radiotherapy.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Glioma / etiology. Intracranial Hemorrhages / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
  • [MeSH-minor] Adult. Anaplasia / etiology. Anaplasia / pathology. Humans. Male. Radiotherapy / adverse effects. Time Factors

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  • (PMID = 18362460.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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27. Zustovich F, Della Puppa A, Scienza R, Anselmi P, Furlan C, Cartei G: Metastatic oligodendrogliomas: a review of the literature and case report. Acta Neurochir (Wien); 2008 Jul;150(7):699-702; discussion 702-3
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  • Oligodendroglioma cells are detectable in the cerebro-spinal fluid in up to 14% of patients [10] and cerebellar and/or spinal cord involvement is a well known phenomenon [3].
  • [MeSH-major] Brain Neoplasms / pathology. Liver Neoplasms / secondary. Occipital Lobe. Oligodendroglioma / secondary. Parietal Lobe
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male

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  • [CommentIn] Acta Neurochir (Wien). 2009 Aug;151(8):987 [19424658.001]
  • (PMID = 18548193.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 29
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28. Allen J, Donahue B, Mehta M, Miller DC, Rorke LB, Jakacki R, Robertson P, Sposto R, Holmes E, Vezina G, Muraszko K, Puccetti D, Prados M, Chan KW: A phase II study of preradiotherapy chemotherapy followed by hyperfractionated radiotherapy for newly diagnosed high-risk medulloblastoma/primitive neuroectodermal tumor: a report from the Children's Oncology Group (CCG 9931). Int J Radiat Oncol Biol Phys; 2009 Jul 15;74(4):1006-11
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  • [Title] A phase II study of preradiotherapy chemotherapy followed by hyperfractionated radiotherapy for newly diagnosed high-risk medulloblastoma/primitive neuroectodermal tumor: a report from the Children's Oncology Group (CCG 9931).
  • PURPOSE: To verify feasibility and monitor progression-free survival and overall survival in children with high-risk medulloblastoma and noncerebellar primitive neuroectodermal tumors (PNETs) treated in a Phase II study with preradiotherapy chemotherapy (CHT) followed by high-dose, hyperfractionated craniospinal radiotherapy (CSRT).
  • Treatment was initiated with five alternating monthly cycles of CHT (A [cisplatin, cyclophosphamide, etoposide, and vincristine], B [carboplatin and etoposide], A, B, and A) followed by hyperfractionated CSRT (40 Gy) with a boost to the primary tumor (72 Gy) given in twice-daily 1-Gy fractions.
  • No significant differences were detected in subset analysis related to response to CHT, site of primary tumor, postoperative residual disease, or M stage.

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  • (PMID = 19356859.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA003888-44; United States / NCI NIH HHS / CA / U10 CA003888; United States / NCI NIH HHS / CA / U10 CA098543; United States / NCI NIH HHS / CA / U10 CA003888-44
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ NIHMS128135; NLM/ PMC2739055
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29. Muscarella LA, Barbano R, Augello B, Formica V, Micale L, Zelante L, D'Agruma L, Merla G: An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma. J Hum Genet; 2007;52(6):485-91
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  • [Title] An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Cerebellar Neoplasms / genetics. Hemangioblastoma / genetics. Kidney Neoplasms / genetics. Promoter Regions, Genetic. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics
  • [MeSH-minor] Adult. Allelic Imbalance. Base Sequence. Electrophoretic Mobility Shift Assay. Humans. Male. Molecular Sequence Data. Mutation. Polymerase Chain Reaction


30. Anton T, Guttierez J, Rock J: Tentorial schwannoma: a case report and review of the literature. J Neurooncol; 2006 Feb;76(3):307-11
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  • Magnetic resonance imaging revealed a large tentorial-based tumor.
  • At surgery the origin of the tumor was clearly the tentorium, and while the trigeminal nerve was displaced, it easily separated from the mass.
  • CONCLUSION: While there are few reported cases of tentorial-based schwannoma, these tumors have been noted in unusual locations within the intracranial vault, and clinicians should be aware of this diversity of origin.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Dura Mater / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Meningioma / pathology. Neurosurgical Procedures. Tomography, X-Ray Computed. Trigeminal Nerve / pathology

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  • (PMID = 16200344.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Myong NH, Park BJ: Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient. Yonsei Med J; 2009 Aug 31;50(4):576-81
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  • [Title] Malignant glioma arising at the site of an excised cerebellar hemangioblastoma after irradiation in a von Hippel-Lindau disease patient.
  • The patient was a 25 year-old male with multiple hemangioblastomas at the cerebellum and spinal cord, multiple pancreatic cysts and a renal cell carcinoma; he was diagnosed as having VHL disease.
  • The largest hemangioblastoma at the right cerebellar hemisphere was completely removed, and he received high-dose irradiation postoperatively.
  • The tumor recurred at the same site 7 years later, which was a malignant glioma with no evidence of hemangioblastoma.
  • The malignant glioma showed molecular genetic profiles of radiation-induced tumors because of its diffuse p53 immunostaining and the loss of p16 immunoreactivity.
  • The genetic study to find the loss of heterozygosity (LOH) of VHL gene revealed that only the cerebellar hemangioblastoma showed allelic losses for the gene.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Glioma / diagnosis. Glioma / etiology. Hemangioblastoma / surgery. Radiotherapy / adverse effects. von Hippel-Lindau Disease / radiotherapy
  • [MeSH-minor] Adult. Humans. Male


32. Hartmann W, Digon-Söntgerath B, Koch A, Waha A, Endl E, Dani I, Denkhaus D, Goodyer CG, Sörensen N, Wiestler OD, Pietsch T: Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res; 2006 May 15;12(10):3019-27
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  • PURPOSE: Medulloblastomas represent the most frequent malignant brain tumors of childhood.
  • They are supposed to originate from cerebellar neural precursor cells.
  • Even more important, PTEN mRNA and protein levels were found to be significantly lower in medulloblastomas compared with normal cerebellar tissue of different developmental stages.
  • Reduction of PTEN expression was found to be associated with PTEN promoter hypermethylation in 50% of the tumor samples.
  • [MeSH-major] Cell Proliferation. Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. PTEN Phosphohydrolase / genetics. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism
  • [MeSH-minor] Adult. Child. DNA Mutational Analysis. Humans. Immunohistochemistry. Loss of Heterozygosity. Polymerase Chain Reaction. Polymorphism, Genetic. Signal Transduction. Tumor Cells, Cultured

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  • (PMID = 16707597.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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33. Gajjar A: High-dose chemotherapy for recurrent medulloblastoma: time for a reappraisal. Cancer; 2008 Apr 15;112(8):1643-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Humans. Neoadjuvant Therapy. Radiotherapy, Adjuvant. Stem Cell Transplantation. Treatment Outcome

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  • [CommentOn] Cancer. 2008 Apr 15;112(8):1805-11 [18300237.001]
  • (PMID = 18306390.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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34. Jacobson GP, McCaslin DL, Kaylie DM: Alexander's law revisited. J Am Acad Audiol; 2008 Sep;19(8):630-8
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  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle. Nystagmus, Pathologic / etiology. Pregnancy Complications, Neoplastic / pathology. Vestibular Diseases / complications. Vestibular Diseases / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Pregnancy

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  • (PMID = 19323354.001).
  • [ISSN] 1050-0545
  • [Journal-full-title] Journal of the American Academy of Audiology
  • [ISO-abbreviation] J Am Acad Audiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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35. Kabacińska A, Dabrowska A, Tarnowska C, Cyryłowski L: [Diagnostic problems of rare cerebellopontine angle tumors]. Otolaryngol Pol; 2007;61(2):184-7
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  • [Title] [Diagnostic problems of rare cerebellopontine angle tumors].
  • Astrocytoma (neuroepithelial tumor) determine about 25% all the cerebroma but their original location in cerebellopontine angle is seldom.
  • In case of this kind of tumors in this place, the symptoms can be non-characteristic and similar to these, which appear in the acoustic neurinoma.
  • The most important in case of this diagnosis is both that this tumors can infiltrate of the brain tissues and the fact that they can transformate toward the anaplastic astrocytoma or glioblastoma multiforme (very malignant tumors).
  • MATERIAL AND METHODS: [corrected] A rare case of astrocytoma presenting as a cerebellopontine angle tumor is discussed.
  • The special characteristics of this tumor and unusual clinical course are disscused.
  • [MeSH-major] Astrocytoma / radiography. Astrocytoma / surgery. Cerebellar Neoplasms / radiography. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / radiography. Cerebellopontine Angle / surgery. Facial Nerve Diseases / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Postoperative Complications. Treatment Outcome

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  • (PMID = 17668807.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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41. Stein PJ: A case of cerebellopontine angle meningioma presenting with neck and upper extremity pain. J Manipulative Physiol Ther; 2009 Nov-Dec;32(9):776-80
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  • INTERVENTION AND OUTCOME: Magnetic resonance imaging studies of the neck and brain revealed a posterior fossa tumor, which was eventually diagnosed as a benign meningioma.
  • Partial surgical removal of the tumor mass was followed by radiation therapy.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / radiography. Cerebellopontine Angle / pathology. Cerebellopontine Angle / radiography. Meningioma / pathology. Meningioma / radiography. Neck / physiopathology. Pain / etiology. Pain / physiopathology. Upper Extremity / physiopathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 20004806.001).
  • [ISSN] 1532-6586
  • [Journal-full-title] Journal of manipulative and physiological therapeutics
  • [ISO-abbreviation] J Manipulative Physiol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Brockmann MA, Nowak G, Reusche E, Russlies M, Petersen D: Zebra sign: cerebellar bleeding pattern characteristic of cerebrospinal fluid loss. Case report. J Neurosurg; 2005 Jun;102(6):1159-62
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  • [Title] Zebra sign: cerebellar bleeding pattern characteristic of cerebrospinal fluid loss. Case report.
  • Less often, spinal or supratentorial interventions cause remote cerebellar hemorrhage (RCH).
  • Hemorrhage is often characterized by a typical, streaky bleeding pattern due to blood spreading in the cerebellar sulci.
  • [MeSH-minor] Acute Disease. Adult. Cerebellum / blood supply. Female. Humans. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Pancoast Syndrome / surgery. Spinal Diseases / surgery

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  • (PMID = 16028781.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Akar S, Drappatz J, Hsu L, Blinder RA, Black PM, Kesari S: Hypertrophic olivary degeneration after resection of a cerebellar tumor. J Neurooncol; 2008 May;87(3):341-5
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  • [Title] Hypertrophic olivary degeneration after resection of a cerebellar tumor.
  • We report a case of hypertrophic olivary degeneration due to cerebellar surgery for a low-grade tumor.
  • A 27-year-old female presented with right-sided paresthesias and intermittent leg paresis following a right cerebellar resection of a tumor 2 weeks prior.
  • Hypertrophic olivary degeneration may be mistaken for tumor progression, post-operative vasculopathy or granulation tissue and should be considered in patients undergoing cerebellar surgery.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Neurosurgical Procedures / adverse effects. Olivary Nucleus / pathology
  • [MeSH-minor] Adult. Ataxia / etiology. Diagnosis, Differential. Female. Humans. Hypertrophy. Hypesthesia / etiology. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18217209.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Li XN, Shu Q, Su JM, Adesina AM, Wong KK, Perlaky L, Antalffy BA, Blaney SM, Lau CC: Differential expression of survivin splice isoforms in medulloblastomas. Neuropathol Appl Neurobiol; 2007 Feb;33(1):67-76
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  • The current study was undertaken to examine the mRNA expression of survivin isoforms and their correlation with clinical staging and outcome in 20 medulloblastoma (MB) tumours, three MB cell lines and normal brain tissues (a foetal and an adult cerebellum) by densitometry scanning of 32p-dCTP incorporated reverse transcription polymerase chain reaction (RT-PCR) products and quantitative real-time PCR.
  • Our results showed that the normal adult brain only expressed low levels of survivin-deltaEx3 mRNA, while the foetal brain expressed all three isoforms, with wild-type survivin as the dominant transcript.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. Microtubule-Associated Proteins / biosynthesis. Neoplasm Proteins / biosynthesis
  • [MeSH-minor] Adolescent. Cell Line, Tumor. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism. Humans. Immunohistochemistry. Infant. Inhibitor of Apoptosis Proteins. Isomerism. Male. Neoplasm Staging. RNA, Messenger / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Treatment Outcome

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  • (PMID = 17239009.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases
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45. Antoine JC, Camdessanché JP: [Paraneoplastic neurological syndromes]. Presse Med; 2007 Oct;36(10 Pt 2):1418-26
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  • The classic paraneoplastic neurological syndromes include Lambert-Eaton myasthenic syndrome, limbic encephalitis, sensory neuronopathy, intestinal pseudo-obstruction, subacute cerebellar degeneration, encephalomyelitis, and dermatomyositis.
  • [MeSH-minor] Adult. Anti-Inflammatory Agents / therapeutic use. Antibodies, Neoplasm / immunology. Autoantibodies / immunology. Blotting, Western. Child. Clinical Trials as Topic. Cyclophosphamide / therapeutic use. Humans. Immunoglobulins, Intravenous / therapeutic use. Immunosuppressive Agents / therapeutic use. Methylprednisolone / therapeutic use. Neoplasms / diagnosis. Neoplasms / diagnostic imaging. Neoplasms / epidemiology. Neoplasms / immunology. Plasmapheresis. Positron-Emission Tomography. Prevalence. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 17399944.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies, Neoplasm; 0 / Autoantibodies; 0 / Immunoglobulins, Intravenous; 0 / Immunosuppressive Agents; 8N3DW7272P / Cyclophosphamide; X4W7ZR7023 / Methylprednisolone
  • [Number-of-references] 25
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46. Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ: Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol; 2006 Oct;7(10):813-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Cranial Irradiation / methods. Cyclophosphamide / therapeutic use. Hematopoietic Stem Cell Transplantation / methods. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents, Alkylating / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Disease Progression. Dose-Response Relationship, Drug. Female. Follow-Up Studies. Humans. Male. Prospective Studies. Risk Factors. Survival Analysis. Survival Rate. Transplantation, Autologous. Treatment Outcome

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  • [CommentIn] Curr Neurol Neurosci Rep. 2007 Mar;7(2):130, 132 [17324362.001]
  • [CommentIn] Lancet Oncol. 2006 Oct;7(10):787-9 [17012036.001]
  • [ErratumIn] Lancet Oncol. 2006 Oct;7(10):797
  • (PMID = 17012043.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00003211
  • [Grant] United States / NCI NIH HHS / CA / CA 21765
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide
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47. Selek U, Zorlu F, Hurmuz P, Cengiz M, Turker A, Soylemezoglu F, Gurkaynak M: Craniospinal radiotherapy in adult medulloblastoma. Strahlenther Onkol; 2007 May;183(5):236-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniospinal radiotherapy in adult medulloblastoma.
  • PURPOSE: To evaluate the outcome and prognostic factors of adult patients with medulloblastoma.
  • PATIENTS AND METHODS: 26 adult medulloblastoma patients with a median age of 27 were subjected to craniospinal radiotherapy.
  • Patient characteristics, treatment factors and tumor characteristics failed to show any significance in univariate analysis.
  • CONCLUSION: Yet, the current standard of care seems to remain craniospinal irradiation after maximal surgical resection of the primary neoplasm without clear indications for adjuvant chemotherapy.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Cranial Irradiation. Medulloblastoma / radiotherapy. Spine / radiation effects
  • [MeSH-minor] Adolescent. Adult. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17497094.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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48. Morris EB, Phillips NS, Laningham FH, Patay Z, Gajjar A, Wallace D, Boop F, Sanford R, Ness KK, Ogg RJ: Proximal dentatothalamocortical tract involvement in posterior fossa syndrome. Brain; 2009 Nov;132(Pt 11):3087-95
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  • Posterior fossa syndrome is characterized by cerebellar dysfunction, oromotor/oculomotor apraxia, emotional lability and mutism in patients after infratentorial injury.
  • Postoperative magnetic resonance signal abnormalities within the superior cerebellar peduncles and midbrain were observed more often in patients with posterior fossa syndrome (P = 0.030 and 0.003, respectively).
  • The fractional anisotropy of water was lower in the bilateral superior cerebellar peduncles, in the bilateral fornices, white matter region proximate to the right angular gyrus (Tailerach coordinates 35, -71, 19) and white matter region proximate to the left superior frontal gyrus (Tailerach coordinates -24, 57, 20).
  • Our findings suggest that multiple bilateral injuries to the proximal dentatothalamocortical pathways may predispose the development of posterior fossa syndrome, that functional disruption of the white matter bundles containing efferent axons within the superior cerebellar peduncles is a critical underlying pathophysiological component of posterior fossa syndrome, and that decreased fractional anisotropy in the fornices and cerebral cortex may be related to the abnormal neurobehavioural symptoms of posterior fossa syndrome.

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  • (PMID = 19805491.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD49888; United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2781745
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49. Gelabert González M: [Posterior fossa hemangioblastomas]. Neurologia; 2007 Dec;22(10):853-9
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  • INTRODUCTION: Hemangioblastomas are histologically benign lesions that comprise 1-2 % of primary nervous system tumours and 8-12 % of all posterior fossa lesions in the adult.
  • Tumors were located on cerebellar hemisphere (17), cerebellar vermis (4) and brain stem (1).
  • Tumors were cyst in 16 cases, solid in 8 cases.
  • Total tumor removal was achieved in 21 patients (95 %), and incomplete removal in 1 cases.
  • CONCLUSIONS: Hemangioblastomas are benign tumors of uncertain origin that are located predominantly in the posterior cranial fossa and the spinal cord.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Hemangioblastoma / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Cranial Fossa, Posterior. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17671853.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] Spain
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50. McClelland S 3rd, Garcia RE, Monaco SE, Goldman JE, Olson TJ, Kim GH, Petrylak DP, Goodman RR: Carcinomatous meningitis from urachal carcinoma: the first reported case. J Neurooncol; 2006 Jan;76(2):171-4
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  • We report a patient with known primary carcinoma of the urachus who presented with headaches, nausea, vomiting and ataxia 1 week following resection of a nodular arachnoidal metastasis (indenting the cerebellum).
  • [MeSH-major] Adenocarcinoma / pathology. Meningeal Neoplasms / pathology. Urachus. Urologic Neoplasms / pathology
  • [MeSH-minor] Adult. Cerebellar Neoplasms / cerebrospinal fluid. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / secondary. Fatal Outcome. Humans. Lung Neoplasms / cerebrospinal fluid. Lung Neoplasms / pathology. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 16307300.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Ypma PF, Wijermans PW, Koppen H, Sillevis Smitt PA: Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma. Neth J Med; 2006 Jul-Aug;64(7):243-7
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  • [Title] Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma.
  • Paraneoplastic cerebellar degeneration (PCD) can present as a severe and (sub)acute cerebellar syndrome.
  • PCD can accompany different kinds of neoplasms including small cell lung cancer, adenocarcinoma of the breast and ovary, and Hodgkin's lymphoma.
  • Despite extensive laboratory and radiological evaluations in this patient with rapidly deteriorating cerebellar syndrome, the diagnosis of a paraneoplastic syndrome was only made after several months, when an anti-Tr antibody was detected in his serum.
  • After starting therapy the cerebellar degeneration stabilised.
  • Improvement of the cerebellar syndrome in anti-Tr autoantibody paraneoplastic disease is a rare achievement.
  • [MeSH-major] Cerebellum / pathology. Hodgkin Disease / diagnosis. Paraneoplastic Cerebellar Degeneration / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Dexamethasone / administration & dosage. Etoposide / administration & dosage. Humans. Male. Neoplasm Staging. Positron-Emission Tomography. Radiotherapy, Adjuvant. Remission Induction. Tomography, X-Ray Computed. Vinblastine / administration & dosage


52. Jung TY, Jung S, Lee MC, Kim IY, Kang SS, Kim SH: Papillary endothelial hyperplasia associated with repeated bleeding. Br J Neurosurg; 2005 Oct;19(5):428-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebral Hemorrhage / etiology. Hemangioendothelioma / complications
  • [MeSH-minor] Adult. Endothelium / pathology. Humans. Hyperplasia / pathology. Magnetic Resonance Imaging. Male. Recurrence

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  • (PMID = 16455567.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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53. Zhang J, Yang C, Gu HH, Liang WM: [Intraoperative cranial nerves monitoring under partial neuromuscular relaxation during cerebellopontine angle tumor resection]. Zhonghua Yi Xue Za Zhi; 2008 Jun 3;88(21):1481-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intraoperative cranial nerves monitoring under partial neuromuscular relaxation during cerebellopontine angle tumor resection].
  • OBJECTIVE: To evaluate the efficacy of multiple cranial nerves monitoring under partial Seventy elective neuromuscular relaxation during cerebellopontine angle (CPA) tumor resection.
  • METHODS: patients undergoing CPA tumor resection via microneurosurgery were randomly allocated to 2 equal groups: Group FN receiving intraoperative facial nerve (NF) monitoring and Group MN receiving monitoring of multiple nerves: trigeminal nerve, glossopharyngeal nerve, accessory nerve or hypoglossal nerve other than the FN which were considered at risk by the neurosurgeon preoperatively.
  • Multiple cranial nerves combined with facial nerve monitoring seems unable to increase the short-term protective effects of nerve function after CPA tumor resection.
  • [MeSH-major] Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Cranial Nerves / physiopathology
  • [MeSH-minor] Adult. Feasibility Studies. Female. Humans. Male. Middle Aged. Monitoring, Intraoperative. Muscle Relaxation

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  • (PMID = 18953855.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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54. Brewis S, Baguley DM: Management of tinnitus induced by brainstem and cerebellar infarction associated with complications of cerebello-pontine angle surgery. J Laryngol Otol; 2007 Apr;121(4):393-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of tinnitus induced by brainstem and cerebellar infarction associated with complications of cerebello-pontine angle surgery.
  • Following surgery in the USA in 1992 to remove a large right cerebello-pontine angle tumour, a 39-year-old woman developed severe brainstem and cerebellar infarction.
  • [MeSH-major] Brain Stem Infarctions / complications. Cerebellar Neoplasms / complications. Cerebellopontine Angle. Cerebral Infarction / complications. Meningioma / complications. Tinnitus / etiology
  • [MeSH-minor] Adult. Female. Hearing Aids. Hearing Loss / etiology. Humans. Treatment Outcome

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  • (PMID = 17403265.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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55. Khaw SL, Downie PA, Waters KD, Ashley DM, Heath JA: Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide. Pediatr Blood Cancer; 2007 Sep;49(3):341-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients.
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / drug therapy. Child. Child, Preschool. Cyclophosphamide / administration & dosage. Female. Humans. Medulloblastoma / drug therapy. Osteosarcoma / drug therapy. Spinal Neoplasms / drug therapy

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16333822.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protective Agents; 8N3DW7272P / Cyclophosphamide; NR7O1405Q9 / Mesna
  • [Number-of-references] 7
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56. Rahme R, Rahme RJ, Hourani R, Moussa R, Nohra G, Okais N, Samaha E, Rizk T: Endoscopic third ventriculostomy: the Lebanese experience. Pediatr Neurosurg; 2009;45(5):361-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aqueductal stenosis and tectal tumor were the most common etiologies (63%).
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Kaplan-Meier Estimate. Lebanon / epidemiology. Male. Medulloblastoma / mortality. Medulloblastoma / surgery. Middle Aged. Morbidity. Pinealoma / mortality. Pinealoma / surgery. Prognosis. Retrospective Studies. Risk Factors. Young Adult

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19907200.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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57. Imanaka M, Iida K, Takahashi K, Tsuji K, Nishizawa H, Fukuoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara K: The N131S mutation in the von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas. Endocr J; 2006 Dec;53(6):819-27
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  • von Hippel-Lindau (VHL) disease (VHLD) is a hereditary autosomal dominant syndrome that causes various benign and malignant tumors.
  • VHLD is caused by mutations in the VHL tumor suppressor gene.
  • We also identified somatic loss of heterozygosity (LOH) at chromosome 3p25-26 in the adrenal tumor of the patient.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Cerebellar Neoplasms / genetics. Hemangioblastoma / genetics. Mutation. Pheochromocytoma / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics
  • [MeSH-minor] Adult. Asian Continental Ancestry Group. DNA Mutational Analysis. Family. Humans. Male. Pedigree

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  • (PMID = 17001110.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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58. Matalka I, Alorjani M, Kanaan F, Al-Hussaini M: Medulloblastoma in an adult with cervical lymph node metastasis: a case report and review of the literature. Pathology; 2009 Feb;41(2):197-9
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  • [Title] Medulloblastoma in an adult with cervical lymph node metastasis: a case report and review of the literature.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Lymphatic Metastasis / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures

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  • (PMID = 19152196.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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59. Patrick TA, Giannini C, Ebersold MJ, Link MJ: Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report. J Neurosurg; 2006 Mar;104(3):452-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report.
  • Metastatic seeding or iatrogenic implantation of numerous types of primary central nervous system tumors, typically along cerebrospinal fluid pathways, is a frequently described albeit rare phenomenon and has never been reported in association with vestibular schwannoma (VS).
  • The authors present a case of inadvertent surgical implantation of VS into the cerebellar hemisphere during resection of a recurrent VS in the cerebellopontine angle and internal auditory canal.
  • Five years later--10 years after initial presentation--follow-up imaging revealed a 1-cm recurrence of the VS and a separate 2.2-cm tumor in the inferior cerebellar parenchyma with surrounding edema.
  • Both tumors were removed without complication by reopening the previous retrosigmoid craniotomy.
  • Histological evaluation of these tumors revealed features typical of VS and similar to those of the tissue obtained from the two prior resections.
  • Given the similarities among these tumors in pathological appearance and mitotic index, the presence of the intraparenchymal cerebellar schwannoma was probably due to intraoperative iatrogenic implantation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Neuroma, Acoustic / etiology
  • [MeSH-minor] Adult. Cerebellopontine Angle / pathology. Humans. Iatrogenic Disease. Male. Mitotic Index. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16572663.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. O'Brien J, Thornton J, Cawley D, Farrell M, Keohane K, Kaar G, McEvoy L, O'Brien DF: Extraskeletal myxoid chondrosarcoma of the cerebellopontine angle presenting during pregnancy. Br J Neurosurg; 2008 Jun;22(3):429-32
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  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Chondrosarcoma / pathology. Pregnancy Complications, Neoplastic / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Treatment Outcome


61. Debelius A, Rudolph J, Schrom T: [Lipoma of the cerebellopontine angle - a case report]. Laryngorhinootologie; 2006 Feb;85(2):128-31
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  • On the native T1 sequence the tumor was hyperintense and fat-supression images confirmed the tumor to be fat in origin.
  • Because of the minor symptoms and the small size of the tumor we recommended a BERA after six months and an MRI every year.
  • [MeSH-major] Cerebellar Neoplasms. Cerebellopontine Angle. Lipoma
  • [MeSH-minor] Adult. Disease Progression. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Time Factors. Tinnitus / etiology. Vertigo / etiology

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  • (PMID = 16498542.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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62. Packer RJ, Gajjar A, Vezina G, Rorke-Adams L, Burger PC, Robertson PL, Bayer L, LaFond D, Donahue BR, Marymont MH, Muraszko K, Langston J, Sposto R: Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol; 2006 Sep 1;24(25):4202-8
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  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant / adverse effects. Child. Child, Preschool. Cisplatin / administration & dosage. Cyclophosphamide / administration & dosage. Disease-Free Survival. Female. Humans. Lomustine / administration & dosage. Male. Neoplasm Staging. Neoplasms, Second Primary / diagnosis. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant / adverse effects. Risk Factors. Survival Analysis. Vincristine / administration & dosage


63. Alobid I, Gastón F, Morello A, Guilemany JM, Mullol J: Peripheral primitive neuroectodermal tumor of the cerebellopontine angle. Acta Otolaryngol; 2005 Apr;125(4):426-9
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  • [Title] Peripheral primitive neuroectodermal tumor of the cerebellopontine angle.
  • Peripheral primitive neuroectodermal tumors are highly malignant small cell neoplasms.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Ear, Inner / pathology. Ear, Inner / surgery. Female. Follow-Up Studies. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Retreatment

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  • (PMID = 15823816.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Shoman N, Longridge N: Cerebellar vermis lesions and tumours of the fourth ventricle in patients with positional and positioning vertigo and nystagmus. J Laryngol Otol; 2007 Feb;121(2):166-9
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  • [Title] Cerebellar vermis lesions and tumours of the fourth ventricle in patients with positional and positioning vertigo and nystagmus.
  • We draw attention to the diagnosis of cerebellar vermis lesions and tumours of the fourth ventricle by presenting two cases of patients with positional nystagmus of so called benign paroxysmal type.
  • [MeSH-major] Cerebellar Neoplasms / complications. Nystagmus, Pathologic / etiology. Vertigo / etiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Treatment Outcome

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  • (PMID = 17059627.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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65. Freeman BB 3rd, Iacono LC, Panetta JC, Gajjar A, Stewart CF: Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma. Neuro Oncol; 2006 Apr;8(2):89-95
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  • One patient (four studies) with tumor blockage of CSF flow, which can alter CSF pharmacokinetics, was removed, and the bootstrap analysis was repeated.

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  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / PHS HHS / / P01 23099; United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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66. Lo Muzio L: Nevoid basal cell carcinoma syndrome (Gorlin syndrome). Orphanet J Rare Dis; 2008;3:32
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  • Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is a hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms.
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / epidemiology. Bone Neoplasms / genetics. Bone Neoplasms / pathology. Bone and Bones / abnormalities. Bone and Bones / radiography. Cerebellar Neoplasms / epidemiology. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Child. Female. Humans. Male. Medulloblastoma / epidemiology. Medulloblastoma / genetics. Medulloblastoma / pathology. Odontogenic Cysts / epidemiology. Odontogenic Cysts / genetics. Odontogenic Cysts / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Young Adult

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  • (PMID = 19032739.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 164
  • [Other-IDs] NLM/ PMC2607262
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67. Mekni A, Chelly I, Haouet S, Zitouna M, Kchir N: [Malignant cerebellar ganglioglioma. A case report and review of the literature]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):119-22
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  • [Title] [Malignant cerebellar ganglioglioma. A case report and review of the literature].
  • Ganglioglioma is usually a well differentiated slowly growing mixed neuronal and glial neoplasm corresponding to WHO grade I or II.
  • We report a case of a 25-year-old woman with a family history of neurofibromatosis who presented initially with a World Health Organization grade IV anaplastic ganglioglioma (a mixed ganglion cell multiform tumor glioblastoma).
  • Immunohistochemical analysis clearly distinguished the two tumor cell populations.
  • It also documents the aggressive biologic behavior of this complex neoplasm.
  • [MeSH-major] Ganglioglioma / pathology. Infratentorial Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Immunohistochemistry. Neurofibromatoses / genetics. Tomography, X-Ray Computed

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  • (PMID = 16840971.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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68. Hortobágyi T, Bódi I, Lantos PL: Adult cerebellar liponeurocytoma with predominant pilocytic pattern and myoid differentiation. Neuropathol Appl Neurobiol; 2007 Feb;33(1):121-5
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  • [Title] Adult cerebellar liponeurocytoma with predominant pilocytic pattern and myoid differentiation.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Lipoma / pathology. Neurocytoma / pathology

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  • (PMID = 17239014.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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69. Padovani L, André N, Carrie C, Muracciole X: [Childhood and adult medulloblastoma: what difference?]. Cancer Radiother; 2009 Oct;13(6-7):530-5
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  • [Title] [Childhood and adult medulloblastoma: what difference?].
  • Medulloblastoma is the most frequent childhood brain tumor (30%) but account only for less than 1% of adult brain tumor.
  • Due to the rarety in adult population, no prospective studies and few data about late effects are available.
  • Adult medulloblastoma is a therapeutic challenge and their therapeutic strategies are similar to pediatric protocols.
  • In order to improve the understanding of adult disease and to homogenize the treatment, National Cancer Institute (INCa) stimulated the creation of web conference to discuss each case prospectively and to propose a protocol of treatment.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adult. Age Factors. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Brain Neoplasms / epidemiology. Child. Cognition Disorders / epidemiology. Cognition Disorders / etiology. Combined Modality Therapy. France / epidemiology. Humans. Incidence. Molecular Biology / methods. Radiotherapy / adverse effects. Radiotherapy / methods. Surgical Procedures, Operative

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  • (PMID = 19713143.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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70. Pilkington GJ: Cancer stem cells in the mammalian central nervous system. Cell Prolif; 2005 Dec;38(6):423-33
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  • Malignant tumours intrinsic to the central nervous system (CNS) are among the most difficult of neoplasms to treat effectively.
  • In the 1970s transplacental administration of the potent neurocarcinogen, N-ethyl-N-nitrosourea (ENU), enabled investigation of the sequential development of brain and spinal neoplasms by electron microscopy and immunohistochemistry.
  • In addition to the gliomas, stem cells may have been identified in paediatric tumours including cerebellar medulloblastoma, thought to be of external granule cell neuronal derivation.
  • Interestingly, while the stem cell marker CD133 is expressed in these primitive neuroectodermal tumours (PNETs), the chondroitin sulphate proteoglycan neuronal/glial 2 (NG2), which appears to denote increased proliferative, but reduced migratory activity in adult gliomas, is rarely expressed.
  • The divergent pathways of differentiation of CNS tumours and the possibility of stem cell origin, for some, if not all, such neoplasms remain a matter for debate and continued research, but the presence of self-renewing neural stem cells in the CNS of both children and adults strongly suggests a role for these cells in tumour initiation and resistance to current therapeutic strategies.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Neoplastic Stem Cells / pathology

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  • (PMID = 16300654.001).
  • [ISSN] 0960-7722
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 62
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71. Capovilla M, Kambouchner M, Bernier M, Soulier A, Tissier F, Saintigny P: Late cerebellar relapse of a juvenile bronchial carcinoid. Clin Lung Cancer; 2007 Mar;8(5):339-41
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  • [Title] Late cerebellar relapse of a juvenile bronchial carcinoid.
  • Although epithelial bronchial neoplasm is a cancer frequently observed in adult patients, it is rarely observed in patients who are children.
  • The most frequent histologic subtype is well differentiated neuroendocrine tumor, or carcinoid.
  • They have a variable biologic behavior, ranging from benign to malignant tumors capable of very late recurrence or metastasis.
  • We report the case of a child with a pulmonary carcinoid initially considered typical, who presented with relapse in the cerebellum and mediastinum 16 years later.
  • After review of the pathology slides, primary and metastatic tumors were reclassified as atypical carcinoid according to the criteria of the 2004 World Health Organization classification of lung tumors.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / secondary
  • [MeSH-minor] Adolescent. Adult. Humans. Male

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  • (PMID = 17562235.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Betker AL, Szturm T, Moussavi ZK, Nett C: Video game-based exercises for balance rehabilitation: a single-subject design. Arch Phys Med Rehabil; 2006 Aug;87(8):1141-9
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  • PARTICIPANTS: A young adult with excised cerebellar tumor, 1 middle-aged adult with single right cerebrovascular accident, and 1 middle-aged adult with traumatic brain injury.
  • [MeSH-minor] Adult. Biofeedback, Psychology. Brain Injuries / rehabilitation. Cerebellar Neoplasms / rehabilitation. Equipment Design. Humans. Middle Aged. Stroke / rehabilitation

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  • (PMID = 16876562.001).
  • [ISSN] 0003-9993
  • [Journal-full-title] Archives of physical medicine and rehabilitation
  • [ISO-abbreviation] Arch Phys Med Rehabil
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Mitsuyama T, Ide M, Hagiwara S, Tanaka N, Kawamura H, Aiba M: [Adult choroid plexus papilloma of the posterior fossa: extraventricular location]. No Shinkei Geka; 2005 Aug;33(8):825-9
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  • [Title] [Adult choroid plexus papilloma of the posterior fossa: extraventricular location].
  • Choroid plexus papillomas (CPPs) are rare neuroectodermal neoplasms accounting for 0.4% of all intracranial neoplasms in adults.
  • It is difficult to diagnose CPP preoperatively when the main portion of the tumor is not located in the 4th ventricle.
  • We present a case of a 54-year-old male manifesting slurred speech, nystagmus and cerebellar ataxia.
  • Magnetic resonance imaging demonstrated an intracerebellar solid tumor with multilocular cysts, extending towards both the right lateral medullary region and the foramen of Luschka.
  • Angiographically, via the right posterior inferior cerebellar artery revealed the tumor was faintly opacified.
  • Tumor was subtotally resected through a right suboccipital craniectomy.
  • CPP should be considered among calcified and enhanced masses in the lateral medullary to cerebellopontine angle space in adults, even if the main portion of the tumor is not located in the 4th ventricle.
  • [MeSH-major] Infratentorial Neoplasms / surgery. Papilloma, Choroid Plexus / surgery

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  • [ErratumIn] No Shinkei Geka. 2005 Oct;33(10):977
  • (PMID = 16095214.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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74. Bessler M, Wilson DB, Mason PJ: Dyskeratosis congenita. FEBS Lett; 2010 Sep 10;584(17):3831-8
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  • With this new definition the disease spectrum has broadened and ranges from intrauterine growth retardation, cerebellar hypoplasia, and death in early childhood to asymptomatic mutation carriers whose descendants are predisposed to malignancy, BMF, or pulmonary disease.
  • [MeSH-minor] Adult. Aged. Aging / physiology. Bone Marrow / pathology. Cell Division / genetics. Genetic Diseases, Inborn / enzymology. Genetic Diseases, Inborn / genetics. Humans. Infant, Newborn. Middle Aged. Mutation. Neoplasms / epidemiology. Neoplasms / genetics. Telomerase / genetics. Telomerase / metabolism. Telomere-Binding Proteins / genetics

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  • [Copyright] Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 20493861.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA105312; United States / NCI NIH HHS / CA / R01 CA106995; United States / NCI NIH HHS / CA / R01 CA106995; United States / NCI NIH HHS / CA / R01 CA106995-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Telomere-Binding Proteins; 0 / shelterin, human; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ NIHMS300709; NLM/ PMC3238451
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75. Smith D, MacDougall N, Monk J, Sibtain A, Powell ME, Plowman PN: First quinquennial review of intensity-modulated radiotherapy at St Bartholomew's Hospital, London. Clin Oncol (R Coll Radiol); 2010 Oct;22(8):666-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / radiotherapy. Cerebellar Neoplasms / radiotherapy. Female. Head and Neck Neoplasms / radiotherapy. Hospitals. Humans. London. Male. Medulloblastoma / radiotherapy. Middle Aged. Pelvic Neoplasms / radiotherapy. Quality Control. Rhabdomyosarcoma / radiotherapy

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  • [Copyright] Copyright 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20674299.001).
  • [ISSN] 1433-2981
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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76. Strenger V, Sovinz P, Lackner H, Dornbusch HJ, Lingitz H, Eder HG, Moser A, Urban C: Intracerebral cavernous hemangioma after cranial irradiation in childhood. Incidence and risk factors. Strahlenther Onkol; 2008 May;184(5):276-80
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  • BACKGROUND AND PURPOSE: Radiotherapy is an integral part of various therapeutic regimens in pediatric and adult oncology.
  • [MeSH-major] Brain Neoplasms / etiology. Cranial Irradiation / adverse effects. Hemangioma, Cavernous, Central Nervous System / etiology. Neoplasms, Radiation-Induced / etiology
  • [MeSH-minor] Adolescent. Adult. Cerebellar Neoplasms / radiotherapy. Child. Child, Preschool. Craniopharyngioma / radiotherapy. Ependymoma / radiotherapy. Female. Follow-Up Studies. Frontal Lobe / pathology. Frontal Lobe / radiation effects. Humans. Infant. Magnetic Resonance Imaging. Male. Medulloblastoma / radiotherapy. Parietal Lobe / pathology. Parietal Lobe / radiation effects. Pituitary Neoplasms / radiotherapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy. Radiotherapy Dosage. Risk Factors. Temporal Lobe / pathology. Temporal Lobe / radiation effects. Tomography, X-Ray Computed

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  • (PMID = 18427759.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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77. Cochran DM, Yock TI, Adams JA, Tarbell NJ: Radiation dose to the lens during craniospinal irradiation-an improvement in proton radiotherapy technique. Int J Radiat Oncol Biol Phys; 2008 Apr 1;70(5):1336-42
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  • METHODS AND MATERIALS: Thirty-nine patients with central nervous system tumors who received CSI with a posterior fossa boost were analyzed for the radiation dose to the lens.
  • [MeSH-major] Central Nervous System Neoplasms / radiotherapy. Cranial Irradiation / methods. Lens, Crystalline / radiation effects
  • [MeSH-minor] Adolescent. Adult. Age Factors. Cerebellar Neoplasms / radiotherapy. Child. Child, Preschool. Female. Humans. Male. Medulloblastoma / radiotherapy. Protons / therapeutic use. Radiation Dosage. Radiation Injuries / prevention & control

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  • (PMID = 18029111.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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78. de Divitiis O, Cavallo LM, Dal Fabbro M, Elefante A, Cappabianca P: Freehand dynamic endoscopic resection of an epidermoid tumor of the cerebellopontine angle: technical case report. Neurosurgery; 2007 Nov;61(5 Suppl 2):E239-40; discussion E240
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  • [Title] Freehand dynamic endoscopic resection of an epidermoid tumor of the cerebellopontine angle: technical case report.
  • Epidermoid tumors, especially those located on the CPA, resulting from their avascular and noninfiltrative nature, appear particularly suited to being treated using an endoscopic approach.
  • Magnetic resonance imaging scans revealed a left CPA lesion compatible with an epidermoid tumor, and he was admitted for surgical treatment.
  • TECHNIQUE: We report a patient who underwent freehand dynamic endoscopic resection of an epidermoid tumor of the CPA.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Endoscopy / methods. Neurosurgical Procedures / methods
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Trigeminal Neuralgia / etiology. Trigeminal Neuralgia / surgery

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  • (PMID = 18091219.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Ribi K, Relly C, Landolt MA, Alber FD, Boltshauser E, Grotzer MA: Outcome of medulloblastoma in children: long-term complications and quality of life. Neuropediatrics; 2005 Dec;36(6):357-65
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  • [MeSH-major] Cerebellar Neoplasms / psychology. Medulloblastoma / psychology. Outcome Assessment (Health Care). Quality of Life
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Child. Disease Progression. Endocrine System / physiopathology. Female. Humans. Intelligence. Interviews as Topic. Longitudinal Studies. Male. Neurologic Examination. Neuropsychological Tests. Retrospective Studies. Social Behavior. Statistics, Nonparametric. Surveys and Questionnaires. Time Factors

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  • (PMID = 16429375.001).
  • [ISSN] 0174-304X
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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80. Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ: Subtypes of medulloblastoma have distinct developmental origins. Nature; 2010 Dec 23;468(7327):1095-9
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  • These tumours are thought to arise within the cerebellum, with approximately 25% originating from granule neuron precursor cells (GNPCs) after aberrant activation of the Sonic Hedgehog pathway (hereafter, SHH subtype).
  • Here we provide evidence that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem.
  • We found that genes marking human WNT-subtype medulloblastomas are more frequently expressed in the lower rhombic lip (LRL) and embryonic dorsal brainstem than in the upper rhombic lip (URL) and developing cerebellum.
  • Magnetic resonance imaging (MRI) and intra-operative reports showed that human WNT-subtype tumours infiltrate the dorsal brainstem, whereas SHH-subtype tumours are located within the cerebellar hemispheres.
  • Activating mutations in Ctnnb1 had little impact on progenitor cell populations in the cerebellum, but caused the abnormal accumulation of cells on the embryonic dorsal brainstem which included aberrantly proliferating Zic1(+) precursor cells.
  • These lesions persisted in all mutant adult mice; moreover, in 15% of cases in which Tp53 was concurrently deleted, they progressed to form medulloblastomas that recapitulated the anatomy and gene expression profiles of human WNT-subtype medulloblastoma.

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  • (PMID = 21150899.001).
  • [ISSN] 1476-4687
  • [Journal-full-title] Nature
  • [ISO-abbreviation] Nature
  • [Language] ENG
  • [Databank-accession-numbers] GEO/ GSE24628
  • [Grant] United States / NCI NIH HHS / CA / R01 CA129541-04; United States / NCI NIH HHS / CA / R01 CA129541; United States / NCI NIH HHS / CA / R01CA129541; United States / NINDS NIH HHS / NS / R01 NS037956; United States / NCI NIH HHS / CA / R01 CA129541-02; United States / NCI NIH HHS / CA / R01 CA129541-05; United States / NCI NIH HHS / CA / R01 CA129541-03; United States / NCI NIH HHS / CA / P30CA021765; United States / NCI NIH HHS / CA / 01CA96832; United States / NCI NIH HHS / CA / P01 CA096832-06A18120; United States / NCI NIH HHS / CA / CA096832-078120; United States / NCI NIH HHS / CA / R01 CA129541-01; United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / P01 CA096832; United States / NINDS NIH HHS / NS / R01 NS037956-13; United States / NCI NIH HHS / CA / CA096832-06A18120; United States / NCI NIH HHS / CA / P01 CA096832-078120
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, mouse; 0 / beta Catenin
  • [Other-IDs] NLM/ NIHMS245937; NLM/ PMC3059767
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81. Gilbertson RJ, Langdon JA, Hollander A, Hernan R, Hogg TL, Gajjar A, Fuller C, Clifford SC: Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma. Eur J Cancer; 2006 Mar;42(5):646-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Genes, ras / genetics. Medulloblastoma / genetics. Mitogen-Activated Protein Kinases / genetics. Mutation / genetics. Receptors, Platelet-Derived Growth Factor / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Exons. Female. Humans. Infant. MAP Kinase Signaling System. Male. Polymorphism, Restriction Fragment Length. Receptor, Platelet-Derived Growth Factor alpha / genetics. Receptor, Platelet-Derived Growth Factor alpha / metabolism

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  • (PMID = 16434186.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA023944; United States / NCI NIH HHS / CA / CA21765; United States / NCI NIH HHS / CA / CA96832-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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82. Zilidis G, Cadoux-Hudson TA: Recurrent dural based cystic cerebellar haemangioblastoma in a patient with von Hippel-Lindau disease. Acta Neurochir (Wien); 2007;149(4):433-6
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  • [Title] Recurrent dural based cystic cerebellar haemangioblastoma in a patient with von Hippel-Lindau disease.
  • Surgical excision of cerebellar haemangioblastomas, once they become Symptomatic, is the standard treatment in patients with von Hippel-Lindau disease.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Dura Mater / surgery. Hemangioblastoma / surgery. Meningeal Neoplasms / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Cerebellum / pathology. Cerebellum / physiopathology. Cerebellum / surgery. Female. Humans. Infratentorial Neoplasms / complications. Infratentorial Neoplasms / pathology. Infratentorial Neoplasms / surgery. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 17357827.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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83. Taraszewska A, Czernicki Z, Andrychowski J: Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults. Folia Neuropathol; 2005;43(3):172-7
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  • [Title] Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults.
  • We report an unusual case of pigmented cerebellar pilocytic astrocytoma presenting with posttraumatic hemorrhage in a 38-year-old man with no history related to the tumor.
  • CT and MRI examination after head injury demonstrated unexpectedly the cystic lesion of 2 cm in diameter in the region of the right cerebellar hemisphere and vermis.
  • In the literature, the examples of neuroepithelial tumors with hemosiderin pigmentation of tumor cells have been rarely documented.

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  • (PMID = 16245213.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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84. Longatti P, Basaldella L, Orvieto E, Dei Tos AP, Martinuzzi A: Aquaporin 1 expression in cystic hemangioblastomas. Neurosci Lett; 2006 Jan 16;392(3):178-80
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  • We analyzed AQP1 water channel expression by an immunostaining technique in ten specimens of operated cerebellar cystic hemangioblastomas, for which complete clinical and follow-up records were available.
  • [MeSH-major] Aquaporin 1 / metabolism. Cerebellar Neoplasms / metabolism. Cysts. Gene Expression Regulation, Neoplastic / physiology. Hemangioblastoma / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry / methods. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 16300893.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 146410-94-8 / Aquaporin 1
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85. Utsuki S, Oka H, Sato K, Shimizu S, Suzuki S, Fujii K: Fluorescence diagnosis of tumor cells in hemangioblastoma cysts with 5-aminolevulinic acid. J Neurosurg; 2010 Jan;112(1):130-2
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  • [Title] Fluorescence diagnosis of tumor cells in hemangioblastoma cysts with 5-aminolevulinic acid.
  • Peritumoral hemangioblastoma cysts are usually composed of fibrous tissue without tumor cells.
  • The authors describe the first case in which fluorescence with 5-aminolevulinic acid (5-ALA) was used to diagnose a hemangioblastoma tumor in a peritumoral cyst wall.
  • A 27-year-old woman with a homogeneous, enhanced nodular lesion in the right hemisphere of the cerebellum underwent surgical treatment.
  • The fluorescent cyst consisted of tumor cells.
  • [MeSH-major] Aminolevulinic Acid. Central Nervous System Cysts / diagnosis. Cerebellar Neoplasms / diagnosis. Hemangioblastoma / diagnosis. Photosensitizing Agents
  • [MeSH-minor] Adult. Female. Fluorescence. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures / methods. Photomicrography. Spectrometry, Fluorescence

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  • [CommentIn] J Neurosurg. 2011 Mar;114(3):886; author reply 886-7 [21275559.001]
  • (PMID = 19480541.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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91. Leonetti JP, Anderson DE, Marzo SJ, Origitano TC, Schuman R: Combined transtemporal access for large (>3 cm) meningiomas of the cerebellopontine angle. Otolaryngol Head Neck Surg; 2006 Jun;134(6):949-52
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  • OBJECTIVES: Large meningiomas of the cerebellopontine angle present a formidable surgical challenge due to tumor vascularity, neural attachment, and brain stem compression.
  • RESULTS: Total tumor removal was achieved in 19 of 29 (67%) of the patients and the facial nerve was anatomically preserved in 26 of 29 (89%) of the cases.
  • Of the 10 patients with residual tumor, 6 have been stable without growth, 2 were treated with reoperation for regrowth of disease, and 2 were controlled with localized radiotherapy.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Meningioma / surgery. Temporal Bone / surgery
  • [MeSH-minor] Adult. Aged. Cerebral Angiography. Facial Nerve. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Otologic Surgical Procedures. Retrospective Studies. Treatment Outcome

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  • (PMID = 16730536.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Plotkin SR, Dorfman MV, Loeffler JS: Facial numbness in a man with inguinal and retroperitoneal masses. Nat Clin Pract Oncol; 2005 Jan;2(1):54-8; quiz 1 p following 58
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  • Cranial MRI revealed a 1.6 cm irregular enhancing mass in the left middle cerebellar peduncle.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Demyelinating Diseases / etiology. Hypesthesia / etiology. Paraneoplastic Syndromes / etiology. Seminoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Ataxia / etiology. Face. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed. Vertigo / etiology

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  • (PMID = 16264857.001).
  • [ISSN] 1743-4254
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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93. Jamróz B, Niemczyk K, Morawski K, Bartoszewicz R: [Extended middle fossa approach in treatment of vestibular schwannoma--technique of surgery and postoperative complications]. Otolaryngol Pol; 2010 Jun;64(7):3-9
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  • INTRODUCTION: The main tumor of cerebellopontine angle are vestibular schwannoma (80-90%).
  • MATERIAL AND METHODS: 39 patients (40 tumor) suffered from tumor of cerebellopontine angle, operated by using middle fossa approach in years 1998-2007.
  • CONCLUSION: According to NIH middle fossa approach is one of three possible approaches in microsurgery of cerebellopontine angle tumors.
  • There is possible total tumor removal with hearing preservation.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cranial Fossa, Middle / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology
  • [MeSH-minor] Adult. Aged. Audiometry, Pure-Tone. Cerebellopontine Angle / pathology. Female. Hearing Loss / etiology. Hearing Loss / prevention & control. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Poland / epidemiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 21171303.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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94. Porter RG Sr, Leonetti JP, Ksiazek J, Anderson D: Association between adipose graft usage and postoperative headache after retrosigmoid craniotomy. Otol Neurotol; 2009 Aug;30(5):635-9
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  • INTERVENTION(S): All patients underwent retrosigmoid craniotomy for removal of cerebellopontine angle tumors and received either an abdominal fat graft closure or a standard wound closure.
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Surveys and Questionnaires. Young Adult

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  • (PMID = 19628998.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Furtado SV, Venkatesh PK, Dadlani R, Reddy K, Hegde AS: Adult medulloblastoma and the "dural-tail" sign: rare mimic of a posterior petrous meningioma. Clin Neurol Neurosurg; 2009 Jul;111(6):540-3
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  • [Title] Adult medulloblastoma and the "dural-tail" sign: rare mimic of a posterior petrous meningioma.
  • The role of magnetic resonance spectroscopy in the diagnosis of primitive neuroectodermal tumors is discussed.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Dura Mater / pathology. Infratentorial Neoplasms / pathology. Medulloblastoma / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Spectroscopy. Male. Petrous Bone. Treatment Outcome

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  • (PMID = 19285790.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 19
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96. Sarrazin JL, Marsot-Dupuch K, Chaÿas A: [Pathology of the cerebellopontine angle]. J Radiol; 2006 Nov;87(11 Pt 2):1765-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Diseases. Cerebellar Neoplasms. Cerebellopontine Angle. Epidermal Cyst. Meningeal Neoplasms. Meningioma. Neuroma, Acoustic
  • [MeSH-minor] Adolescent. Adult. Aged. Cochlear Nerve. Diagnosis, Differential. Female. Glossopharyngeal Nerve Diseases / diagnosis. Hemifacial Spasm / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Nerve Compression Syndromes / diagnosis. Tomography, X-Ray Computed. Trigeminal Neuralgia / diagnosis

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  • (PMID = 17171839.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 31
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97. de Oliveira JG, Rassi-Neto A, Ferraz FA, Braga FM: Neurosurgical management of cerebellar cavernous malformations. Neurosurg Focus; 2006;21(1):e11
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  • [Title] Neurosurgical management of cerebellar cavernous malformations.
  • OBJECT: The aim of this study was to analyze cerebellar cavernous malformations (CMs) with respect to epidemiological, clinical, radiological, and therapeutic aspects.
  • The authors reviewed the records of 10 patients whose lesions were located in the cerebellum.
  • CONCLUSIONS: Cerebellar CMs should be analyzed separately from other posterior fossa CMs.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellum / surgery. Cerebral Veins / surgery. Hemangioma, Cavernous, Central Nervous System / surgery. Neurosurgical Procedures / methods. Vascular Surgical Procedures / methods
  • [MeSH-minor] Acute Disease / therapy. Adolescent. Adult. Age Distribution. Cranial Fossa, Posterior / anatomy & histology. Cranial Fossa, Posterior / surgery. Diagnostic Imaging / standards. Disease Progression. Female. Humans. Intracranial Hemorrhages / etiology. Intracranial Hemorrhages / prevention & control. Intracranial Hemorrhages / surgery. Male. Middle Aged. Retrospective Studies. Sex Distribution. Treatment Outcome

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  • (PMID = 16859249.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Okita R, Saeki T, Takashima S, Aogi K, Ohsumi S: Progressive central nervous system metastases in responder patients for outside central nervous system metastases on trastuzumab-based therapy--report of two cases of refractory breast cancer. Hiroshima J Med Sci; 2005 Mar;54(1):35-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During combination treatment, the patients developed cerebellar metastases.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Breast Neoplasms / therapy. Cerebellar Neoplasms / secondary
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Humanized. Antineoplastic Agents / therapeutic use. Blood-Brain Barrier. Combined Modality Therapy. Female. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Radiosurgery. Trastuzumab

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  • (PMID = 15847063.001).
  • [ISSN] 0018-2052
  • [Journal-full-title] Hiroshima journal of medical sciences
  • [ISO-abbreviation] Hiroshima J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; P188ANX8CK / Trastuzumab
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99. Roser F, Nakamura M, Dormiani M, Matthies C, Vorkapic P, Samii M: Meningiomas of the cerebellopontine angle with extension into the internal auditory canal. J Neurosurg; 2005 Jan;102(1):17-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The authors investigated cases of CPA tumors in which the meningioma was inserted in the dura mater in or at the ICA or infiltrated a cranial nerve.
  • Total tumor resection was achieved in 86.1%.
  • In 34 patients, opening of the IAC was required for total tumor removal; this procedure did not influence the patient functional outcome.
  • Functional preservation of the seventh and eighth cranial nerves in cases of tumor extension within the IAC was 86 and 77%, respectively, whereas in cases in which the IAC was involved it was only 60%.
  • In four of five patients in whom the tumor had its origin in the dura mater within the IAC, the seventh or eighth cranial nerve had to be sacrificed to achieve tumor removal because of the lesion's infiltrative behavior.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Ear, Inner / pathology. Meningeal Neoplasms / surgery. Meningioma / surgery
  • [MeSH-minor] Adult. Aged. Evoked Potentials, Auditory / physiology. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / physiopathology. Female. Humans. Intraoperative Care. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / radiography. Postoperative Care. Severity of Illness Index. Tomography, X-Ray Computed. Vestibulocochlear Nerve Diseases / diagnosis. Vestibulocochlear Nerve Diseases / epidemiology. Vestibulocochlear Nerve Diseases / physiopathology

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  • (PMID = 15658091.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Notaridis G, Ebbing K, Giannakopoulos P, Bouras C, Kövari E: Neuropathological analysis of an asymptomatic adult case with Dandy-Walker variant. Neuropathol Appl Neurobiol; 2006 Jun;32(3):344-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuropathological analysis of an asymptomatic adult case with Dandy-Walker variant.
  • Clinically, it is characterized by mental retardation, seizures, cerebellar ataxia as well as symptoms of hydrocephalus.
  • Structural imaging reveal a hypoplasia or agenesis of the cerebellar vermis, enlargement of the fourth ventricle with a posterior fossa cyst.
  • We report the first neuropathological analysis of an adult asymptomatic DW case.
  • Brain computerized tomography showed a massive posterior fossa cyst and hypoplasia of the cerebellum.
  • Macroscopic brain examination revealed hypoplasia of both cerebellar hemispheres and posterior part of the vermis, as well as dilatation of the fourth ventricle without hydrocephalus.
  • There were two foci of cerebellar cortical dysplasia but no ectopic neurons, neuronal loss or gliosis in both cerebellum and cerebral cortex.
  • In comparison with previous reports in DW infants, this adult case displayed milder brain abnormalities compatible with a diagnosis of DW variant.
  • [MeSH-minor] Breast Neoplasms / physiopathology. Comorbidity. Ehlers-Danlos Syndrome / physiopathology. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16640653.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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