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1. Demir MK, Hakan T, Akinci O, Berkman Z: Primary cerebellar glioblastoma multiforme. Diagn Interv Radiol; 2005 Jun;11(2):83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cerebellar glioblastoma multiforme.
  • Primary glioblastoma multiforme of cerebellar hemispheres in adults is a rare condition.
  • We present two cases of unusual de novo cerebellar glioblastomas, one of which is the giant-cell variant.
  • [MeSH-major] Cerebellar Neoplasms / radiography. Glioblastoma / radiography
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Headache / etiology. Humans. Magnetic Resonance Imaging. Male. Nausea / etiology. Neurologic Examination. Vomiting / etiology

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  • (PMID = 15957093.001).
  • [ISSN] 1305-3825
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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2. Sousa R, Sá G, Reimão S, Lopes L, Ruivo J, Albuquerque L, Campos J: [Adult cerebellar medulloblastoma: imaging findings in eight cases]. Acta Med Port; 2006 Nov-Dec;19(6):466-70
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  • [Title] [Adult cerebellar medulloblastoma: imaging findings in eight cases].
  • Medulloblastoma is a brain tumor of neuroepithelial origin, frequent in children but rare in adults.
  • We report CT and MRI imaging findings of 8 adult patients with cerebellar medulloblastoma.
  • Most were lateral, located in the cerebellar hemisphere (63%).
  • They should be considered in the differential diagnosis of cerebellar tumor in adults, especially if they are hyperdense on CT, with well defined margins, with superficial extension and with dural involvement.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / radiography. Medulloblastoma / pathology. Medulloblastoma / radiography
  • [MeSH-minor] Adolescent. Adult. Cerebellum / pathology. Cerebellum / radiography. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17583605.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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3. Lerner A, Gilboa Y, Gerad L, Malinger G, Kidron D, Achiron R: Sonographic detection of fetal cerebellar cavernous hemangioma with in-utero hemorrhage leading to cerebellar hemihypoplasia. Ultrasound Obstet Gynecol; 2006 Dec;28(7):968-71
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  • [Title] Sonographic detection of fetal cerebellar cavernous hemangioma with in-utero hemorrhage leading to cerebellar hemihypoplasia.
  • We report the prenatal diagnosis of cerebellar cavernous angioma.
  • Ultrasound examination at 21 weeks' gestation showed a hyperechogenic lesion measuring 12 mm in diameter, occupying most of the right cerebellar hemisphere.
  • The right cerebellar lobe was hypoplastic and covered with blood clots.
  • Cerebral cavernous malformation should be considered in the differential diagnosis of hyperechogenic lesions in the fetal cerebellum.
  • [MeSH-major] Brain Neoplasms / ultrasonography. Cerebellum / abnormalities. Fetal Diseases / ultrasonography. Hemangioma, Cavernous / ultrasonography
  • [MeSH-minor] Adult. Female. Humans. Infant, Newborn. Intracranial Hemorrhages / complications. Intracranial Hemorrhages / ultrasonography. Pregnancy. Prenatal Diagnosis. Ultrasonography, Prenatal / methods

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  • [Copyright] Copyright 2006 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 17121422.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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4. Pazaitou-Panayiotou K, Kaprara A, Chrisoulidou A, Boudina M, Georgiou E, Patakiouta F, Drimonitis A, Vainas I: Cerebellar metastasis as first metastasis from papillary thyroid carcinoma. Endocr J; 2005 Dec;52(6):653-7
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  • [Title] Cerebellar metastasis as first metastasis from papillary thyroid carcinoma.
  • Even more, cerebellar metastases from papillary thyroid carcinoma (PTC) are exceptional.
  • Computerized tomography (CT) of the brain demonstrated a cerebellar mass and the patient underwent surgery.
  • Although PTC has generally a good prognosis, metastases to the cerebellum can occur, even as the first metastatic site, despite the fact that appropriate therapy (surgery, radioactive iodine therapy, TSH suppression therapy, chemotherapy and external radiotherapy) had been given for the primary tumour.
  • [MeSH-major] Carcinoma, Papillary / secondary. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / secondary. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Humans. Immunohistochemistry. Male. Thyroglobulin / analysis. Thyroglobulin / blood. Thyroidectomy. Tomography, X-Ray Computed

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  • (PMID = 16410655.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 9010-34-8 / Thyroglobulin
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5. Owler BK, Makeham JM, Shingde M, Besser M: Cerebellar liponeurocytoma. J Clin Neurosci; 2005 Apr;12(3):326-9
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  • [Title] Cerebellar liponeurocytoma.
  • A case of cerebellar liponeurocytoma in a 34-year-old man is reported.
  • The differences in behaviour and prognosis between medulloblastoma and cerebellar liponeurocytoma are presented with the corresponding implications for management.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Neurocytoma / pathology
  • [MeSH-minor] Adult. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / radiography. Cerebral Ventricle Neoplasms / surgery. Craniotomy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures

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  • (PMID = 15851097.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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6. Scheid R, Voltz R, Briest S, Kluge R, von Cramon DY: Clinical insights into paraneoplastic cerebellar degeneration. J Neurol Neurosurg Psychiatry; 2006 Apr;77(4):529-30
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  • [Title] Clinical insights into paraneoplastic cerebellar degeneration.
  • Neuroimaging is usually unremarkable in paraneoplastic cerebellar degeneration (PCD), at least in the early stages of the disease.
  • A patient with proven PCD is reported in whom it could be shown that cerebellar atrophy evolved very rapidly and was present in early imaging studies.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Paraneoplastic Cerebellar Degeneration / pathology
  • [MeSH-minor] Adult. Ataxia / diagnosis. Atrophy / pathology. Biopsy. Bone Marrow / pathology. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Carcinoma, Ductal / pathology. Carcinoma, Ductal / surgery. Cerebellum / pathology. Diagnosis, Differential. Disease Progression. Dysarthria / diagnosis. Female. Fluorodeoxyglucose F18. Humans. Magnetic Resonance Imaging. Migraine Disorders / diagnosis. Ovarian Cysts / radiography. Positron-Emission Tomography. Purkinje Cells / pathology. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • [Cites] Gynecol Oncol. 1999 Oct;75(1):178-83 [10502450.001]
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  • [CommentIn] J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):427 [16543516.001]
  • (PMID = 16543537.001).
  • [ISSN] 0022-3050
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2077487
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7. Mattos JP, Marenco HA, Campos JM, Faria AV, Queiroz LS, Borges G, Oliveira Ed: Cerebellar glioblastoma multiforme in an adult. Arq Neuropsiquiatr; 2006 Mar;64(1):132-5
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  • [Title] Cerebellar glioblastoma multiforme in an adult.
  • Cerebellar glioblastoma multiforme (GBM) is a rare tumor.
  • In conjunction, we present a literature review including particular issues, clinical data, advances in imaging studies, pathological characteristics, treatment options and the behavior of such malignant tumor.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellum / pathology. Glioblastoma / pathology

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  • (PMID = 16622570.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 16
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8. Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M: Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol; 2006 Jun-Jul;27(6):1362-9
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  • [Title] Apparent diffusion coefficients for differentiation of cerebellar tumors in children.
  • We hypothesized that cerebellar tumors in children can be differentiated by their ADC values.
  • METHODS: Brain MR imaging studies that included ADC maps were retrospectively reviewed in 32 patients with histologically proved cerebellar neoplasm.
  • There were 17 juvenile pilocytic astrocytomas (JPA), 8 medulloblastomas, 5 ependymomas, and 2 rhabdoid (atypical teratoid/rhabdoid tumor [AT/RT]) tumors.
  • Absolute ADC values of contrast-enhancing solid tumor regions and ADC ratios (ADC of solid tumor to ADC of normal-appearing white matter) were compared with the histologic diagnosis.
  • ADC ratios were also significantly different among these 3 tumor types.
  • CONCLUSION: Assessment of ADC values of enhancing solid tumor is a simple and reliable technique for preoperative differentiation of cerebellar tumors in pediatric patients.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Astrocytoma / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / diagnosis. Ependymoma / pathology. Female. Humans. Infant. Male. Medulloblastoma / diagnosis. Medulloblastoma / pathology

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  • [CommentIn] Nat Clin Pract Neurol. 2007 Feb;3(2):78-9 [17279080.001]
  • (PMID = 16775298.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Akil H, Statham PF, Götz M, Bramley P, Whittle IR: Adult cerebellar mutism and cognitive-affective syndrome caused by cystic hemangioblastoma. Acta Neurochir (Wien); 2006 May;148(5):597-8
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  • [Title] Adult cerebellar mutism and cognitive-affective syndrome caused by cystic hemangioblastoma.
  • Cerebellar mutism is a rare phenomenon often described in children following surgical intervention in the posterior fossa.
  • In this report we present a very unusual case of pre-operative cerebellar mutism in an adult in the context of cognitive-affective syndrome caused by cystic hemangioblastoma.
  • [MeSH-major] Affective Symptoms / etiology. Cerebellar Neoplasms / psychology. Cognition Disorders / etiology. Hemangioblastoma / psychology. Mutism / etiology

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  • [CommentIn] Acta Neurochir (Wien). 2007;149(4):437; Author reply 437-8 [17426999.001]
  • (PMID = 16200477.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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10. Aker FV, Ozkara S, Eren P, Peker O, Armağan S, Hakan T: Cerebellar liponeurocytoma/lipidized medulloblastoma. J Neurooncol; 2005 Jan;71(1):53-9
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  • [Title] Cerebellar liponeurocytoma/lipidized medulloblastoma.
  • Cerebellar liponeurocytoma that has been recently identified as a distinct entity by the World Health Organization is characterized by areas of lipomatous differentiation and apparently by a favorable prognosis.
  • Although, basically all reported cases share a similar histological pattern, i.e. focal accumulations of adiposities in an otherwise typical small cell tumor like central neurocytoma, some clinical properties such as (age, proliferative potential, therapy and survival) are not uniform.
  • The exact biological behavior of this special variant tumor is established.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis. Neoplasms, Adipose Tissue / diagnosis. Neurocytoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Treatment Outcome

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  • (PMID = 15719276.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 33
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11. Wells EM, Walsh KS, Khademian ZP, Keating RF, Packer RJ: The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder. Dev Disabil Res Rev; 2008;14(3):221-8
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  • [Title] The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder.
  • The postoperative cerebellar mutism syndrome (CMS), consisting of diminished speech output, hypotonia, ataxia, and emotional lability, occurs after surgery in up to 25% of patients with medulloblastoma and occasionally after removal of other posterior fossa tumors.
  • Theories about the pathophysiology of CMS have evolved along with our understanding of the cerebellum as an important structure in the distributive neurocircuitry underlying complex speech, cognition, and behavior.
  • CMS shares many similarities with the cerebellar cognitive affective syndrome, more commonly described in adults and consisting of disturbances of executive function, visuospatial skills, nonmotor language, and affect regulation.
  • [MeSH-major] Brain Damage, Chronic / etiology. Cerebellar Neoplasms / surgery. Cognition Disorders / etiology. Cranial Fossa, Posterior / surgery. Developmental Disabilities / etiology. Medulloblastoma / surgery. Mood Disorders / etiology. Mutism / etiology. Skull Base Neoplasms / surgery. Survivors / psychology
  • [MeSH-minor] Adolescent. Adult. Child. Child Behavior Disorders / diagnosis. Child Behavior Disorders / etiology. Child Behavior Disorders / psychology. Follow-Up Studies. Humans. Risk Factors. Young Adult

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18924161.001).
  • [ISSN] 1940-5529
  • [Journal-full-title] Developmental disabilities research reviews
  • [ISO-abbreviation] Dev Disabil Res Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 90
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12. Rafique MZ: Lhermitte-Duclos disease (dysplastic cerebellar gangliocytoma). J Coll Physicians Surg Pak; 2005 Jan;15(1):48-9
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  • [Title] Lhermitte-Duclos disease (dysplastic cerebellar gangliocytoma).
  • This case report describes an adult male presenting with ataxia.
  • Dysplastic cerebellar gangliocytoma, the Lhermitte-Duclos disease, was diagnosed on neuroimaging.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Ganglioneuroma / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 15670528.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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13. Afshar-Oromieh A, Linhart H, Podlesek D, Schrempf W, Schackert G, Krex D: Postoperative cerebellar mutism in adult patients with Lhermitte-Duclos disease. Neurosurg Rev; 2010 Oct;33(4):401-8
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  • [Title] Postoperative cerebellar mutism in adult patients with Lhermitte-Duclos disease.
  • Cerebellar mutism (CM) is a rare and severe form of speech and language impairment, mostly diagnosed in children and adolescents and rarely reported in adults.
  • We also report two illustrative cases of CM following surgical treatment of Lhermitte-Duclos disease (LDD; dysplastic gangliocytoma) in two adult patients.
  • LDD is a rare benign cerebellar tumor.
  • However, surgery is hampered by the difficulty to distinguish between tumor and healthy cerebellar tissue, which may result in extensive resection and cause neurological deficits such as CM.
  • Despite the severity, CM carries a favorable prognosis and generally resolves within a few months.To conclude, we review the clinical signs and particularly the pathophysiological observations and anatomical structures affected in the development of postoperative CM and contribute two cases illustrating the pathogenesis, prognosis, and possible prevention of this syndrome, to focus that CM might also occur in adults even in association with rare tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebellar Diseases / etiology. Cerebellar Diseases / pathology. Cerebellar Diseases / psychology. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellum / pathology. Cerebellum / surgery. Epilepsy, Absence / etiology. Ganglioneuroma / pathology. Ganglioneuroma / surgery. Headache / etiology. Humans. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Prognosis. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 20668902.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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14. Sander T, Sprenger A, Neumann G, Machner B, Gottschalk S, Rambold H, Helmchen C: Vergence deficits in patients with cerebellar lesions. Brain; 2009 Jan;132(Pt 1):103-15
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  • [Title] Vergence deficits in patients with cerebellar lesions.
  • The cerebellum is part of the cortico-ponto-cerebellar circuit for conjugate eye movements.
  • Recent animal data suggest an additional role of the cerebellum for the control of binocular alignment and disconjugate, i.e. vergence eye movements.
  • The aim of this study was to investigate whether circumscribed cerebellar lesions affect these dynamic vergence eye movements.
  • Disconjugate fast and slow vergence, conjugate smooth pursuit and saccades were binocularly recorded by a scleral search coil system in 20 patients with acute cerebellar lesions (all ischemic strokes except for one) and 20 age-matched healthy controls.
  • We conclude that (i) the human cerebellum, in particular the vermis, is involved in the processing of dynamic vergence eye movements and (ii) cerebellar lesions elicit dissociable effects on fast and slow vergence.
  • [MeSH-major] Cerebellum / blood supply. Cerebral Infarction / complications. Ocular Motility Disorders / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brain Mapping / methods. Cerebellar Neoplasms / complications. Convergence, Ocular. Eye Movement Measurements. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Pursuit, Smooth. Saccades

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  • (PMID = 19036765.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Nomura M, Hasegawa M, Kita D, Yamashita J, Minato H, Nakazato Y: Cerebellar gliofibroma with numerous psammoma bodies. Clin Neurol Neurosurg; 2006 Jun;108(4):421-5
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  • [Title] Cerebellar gliofibroma with numerous psammoma bodies.
  • Computed tomography (CT) showed a high-density mass without contrast enhancement in the right cerebellar hemisphere.
  • Pathological examinations revealed a biphasic pattern consisting of tumor cells in sparce cellularity and dense fibrous connective tissue.
  • The tumor cells expressed glial fibrillary acidic protein and S-100, but not p53, vimentin and EMA.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Fibroma / pathology. Glioma / pathology. Inclusion Bodies / pathology
  • [MeSH-minor] Adult. Calcinosis / complications. Calcinosis / pathology. Craniotomy. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 16644412.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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16. Fancellu R, Pareyson D, Corsini E, Salsano E, Laurà M, Bernardi G, Antozzi C, Andreetta F, Colecchia M, Di Donato S, Mariotti C: Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia. Eur Neurol; 2009;62(6):356-61
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  • [Title] Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia.
  • In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated.
  • In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified.
  • Two women had anti-Yo antibodies; two patients had anti-gliadin antibodies in the presence of celiac disease; one patient had a complex autoimmune disorder associated with anti-Ro-52/SS-A and anti-muscle-specific kinase antibodies, and a patient developed subacute cerebellar syndrome associated with the presence of a prostatic adenocarcinoma and atypical antibodies reacting both with cerebellar tissue and with the prostatic tumor.
  • Our study confirms previous findings in paraneoplastic syndromes, and indicates that at least 10% of sporadic cerebellar ataxia may be related to immune-mediated mechanisms.
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / immunology. Blotting, Western. Celiac Disease / complications. Celiac Disease / immunology. Electromyography. Enzyme-Linked Immunosorbent Assay. Female. Gliadin / immunology. Glutamate Decarboxylase / immunology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Nerve Tissue Proteins / immunology. Neurons / immunology. Prostatic Neoplasms / complications. Prostatic Neoplasms / immunology. Ribonucleoproteins / immunology

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  • (PMID = 19786780.001).
  • [ISSN] 1421-9913
  • [Journal-full-title] European neurology
  • [ISO-abbreviation] Eur. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / CDR2 protein, human; 0 / Nerve Tissue Proteins; 0 / Ribonucleoproteins; 0 / SS-A antigen; 9007-90-3 / Gliadin; EC 4.1.1.15 / Glutamate Decarboxylase
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17. Yoshida S, Takahashi H: Cerebellar metastases in patients with cancer. Surg Neurol; 2009 Feb;71(2):184-7; discussion 187

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar metastases in patients with cancer.
  • BACKGROUND: Cerebellar metastases are considered a negative prognostic factor in patients with systemic cancers.
  • We retrospectively reviewed the treatment and outcome of 109 patients with cerebellar metastases.
  • METHODS: A total of 1240 patients with metastatic brain tumors were identified and treated between January 1990 and December 2005.
  • RESULTS: Cerebellar metastases occurred in 109 (8.7%) of these patients.
  • CONCLUSIONS: Aggressive treatment including surgical resection and radiotherapy for patients and high performance status (KPS of at least 70) are associated with longer survival for selected patients with cerebellar metastases.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / secondary. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Radiosurgery. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18295837.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Buklina SB, Iakovlev SB, Bukharin EIu, Kheĭreddin AS, Bocharov AV, Sazonov IA, Okishev DN: [Cognitive disturbances in patients with arteriovenous malformations, cerebellar cavernomas and hematomas]. Zh Nevrol Psikhiatr Im S S Korsakova; 2009;109(6):15-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cognitive disturbances in patients with arteriovenous malformations, cerebellar cavernomas and hematomas].
  • A clinical-neuropsychological study using Luria's method has been conducted in 13 patients with arteriovenous malformations (AVM) and 12 patients with cerebellar cavernomas and hematomas.
  • After a surgery on the right cerebellar hemisphere, some patients had perseverations and micrographia in writing.
  • The disturbances of verbal memory were found in the lesion of both right and left cerebellar hemispheres that is the functional asymmetry of cerebellar hemispheres was not pronounced.
  • In some patients with the lesion of right cerebellar hemisphere, the disinhibition of speech, similar to that in patients with the lesion of right frontal lobe, was found.
  • The most distinct cognitive disturbances were found after surgeries of the superior cerebellar artery.
  • Possible mechanisms of the cerebellum's role in cognitive functions are discussed.

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  • (PMID = 19672221.001).
  • [ISSN] 1997-7298
  • [Journal-full-title] Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
  • [ISO-abbreviation] Zh Nevrol Psikhiatr Im S S Korsakova
  • [Language] RUS
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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19. Grahovac G, Tomac D, Lambasa S, Zoric A, Habek M: Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir (Wien); 2009 Jun;151(6):653-7
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  • [Title] Cerebellar glioblastomas: pathophysiology, clinical presentation and management.
  • Glioblastoma multiforme usually affects the cerebral hemispheres with the peak age of onset in the sixth or seventh decade, while cerebellar glioblastoma multiforme is a rare tumour especially in younger patients.
  • We report a 28 year old patient with primary multi-focal cerebellar glioblastoma multiforme and review the pathophysiology, clinical presentation, diagnosis and treatment of cerebellar glioblastomas.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Genetic Predisposition to Disease / genetics. Glioblastoma / pathology. Mutation / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cerebellum / pathology. Cerebellum / radiography. Cerebellum / surgery. Fatal Outcome. Female. Fourth Ventricle / pathology. Fourth Ventricle / surgery. Headache / etiology. Humans. Hydrocephalus / etiology. Intracranial Hypertension / etiology. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Reoperation. Tomography, X-Ray Computed. Vomiting / etiology

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  • (PMID = 19319469.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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20. Huber JF, Bradley K, Spiegler BJ, Dennis M: Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood. Childs Nerv Syst; 2006 Feb;22(2):132-8
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  • [Title] Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood.
  • BACKGROUND: Following cerebellar tumor resection, some patients develop transient cerebellar mutism (TCM).
  • Although the mutism resolves, it is not known whether there are long-term motor speech deficits in patients with TCM that are in excess of those in individuals with cerebellar tumors who had not developed postoperative TCM.
  • METHODS: Long-term survivors of cerebellar tumors resected in childhood who developed TCM were matched to survivors without TCM and to controls.
  • RESULTS: Tumor survivors who had TCM had significantly more ataxic dysarthric speech and slower speech than either those without TCM or controls and were more dysfluent than controls.
  • Tumor survivors without TCM did not differ from controls on ataxic dysarthria or speech rate.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Medulloblastoma / surgery. Mutism / etiology. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Case-Control Studies. Child. Dysarthria / etiology. Dysarthria / physiopathology. Follow-Up Studies. Humans. Male. Time Factors

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  • [CommentIn] Childs Nerv Syst. 2007 May;23(5):477 [17384951.001]
  • (PMID = 16155765.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P01 HD 35946
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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21. Megdiche Bazarbacha H, Nagi S, Zouauoi W, Belghith L, Sebai R, Touibi S: [Cerebellar liponeurocytoma. Case report]. Tunis Med; 2005 Feb;83(2):120-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cerebellar liponeurocytoma. Case report].
  • The cerebellar liponeurocytoma is a rarely and recently described tumour.
  • We report the case of a 38-year-old woman without particular pathological antecedent with a few months history of headache and dizziness, aggravated since 2 days by signs of increased intracranial pressure and cerebellar dysfunction.
  • The histopathological and immunohistochemical studies concluded to a cerebellar liponeurocytoma.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Lipoma / pathology. Lipoma / surgery. Neurocytoma / pathology. Neurocytoma / surgery
  • [MeSH-minor] Adult. Dizziness / etiology. Female. Headache / etiology. Humans. Immunohistochemistry. Intracranial Pressure. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15969237.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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22. de Oliveira JG, Rassi-Neto A, Ferraz FA, Braga FM: Neurosurgical management of cerebellar cavernous malformations. Neurosurg Focus; 2006;21(1):e11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurosurgical management of cerebellar cavernous malformations.
  • OBJECT: The aim of this study was to analyze cerebellar cavernous malformations (CMs) with respect to epidemiological, clinical, radiological, and therapeutic aspects.
  • The authors reviewed the records of 10 patients whose lesions were located in the cerebellum.
  • CONCLUSIONS: Cerebellar CMs should be analyzed separately from other posterior fossa CMs.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellum / surgery. Cerebral Veins / surgery. Hemangioma, Cavernous, Central Nervous System / surgery. Neurosurgical Procedures / methods. Vascular Surgical Procedures / methods
  • [MeSH-minor] Acute Disease / therapy. Adolescent. Adult. Age Distribution. Cranial Fossa, Posterior / anatomy & histology. Cranial Fossa, Posterior / surgery. Diagnostic Imaging / standards. Disease Progression. Female. Humans. Intracranial Hemorrhages / etiology. Intracranial Hemorrhages / prevention & control. Intracranial Hemorrhages / surgery. Male. Middle Aged. Retrospective Studies. Sex Distribution. Treatment Outcome

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  • (PMID = 16859249.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Kovács T, Osztie E, Bodrogi L, Pajor P, Farsang M, Juhász C, Szirmai I: Cerebellar developmental venous anomalies with associated vascular pathology. Br J Neurosurg; 2007 Apr;21(2):217-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar developmental venous anomalies with associated vascular pathology.
  • Cerebellar developmental venous anomalies (CDVA) are benign conditions, although sometimes they are associated with haemorrhages and reported to be symptomatic.
  • Four patients had CDVA and an associated vascular pathology: two pontine cavernomas, one asymptomatic arteriovenous malformation (this is the first published case in the literature) and one cerebellar infarct with a developmental variation of the posterior fossa venous circulation.
  • [MeSH-major] Cerebellar Diseases / complications. Intracranial Arteriovenous Malformations / complications
  • [MeSH-minor] Adult. Brain Stem Neoplasms / complications. Brain Stem Neoplasms / pathology. Female. Follow-Up Studies. Hemangioma, Cavernous / complications. Hemangioma, Cavernous / pathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 17453792.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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24. Mainland JD, Johnson BN, Khan R, Ivry RB, Sobel N: Olfactory impairments in patients with unilateral cerebellar lesions are selective to inputs from the contralesional nostril. J Neurosci; 2005 Jul 6;25(27):6362-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Olfactory impairments in patients with unilateral cerebellar lesions are selective to inputs from the contralesional nostril.
  • Functional imaging studies of olfaction have consistently reported odorant-induced activation of the cerebellum.
  • However, the cerebellar role in olfaction remains unknown.
  • We examined the olfactory and olfactomotor abilities of patients with unilateral cerebellar lesions, comparing performance within subjects across nostrils, as well as between subjects with age-matched and young controls.
  • In conclusion, cerebellar lesions impacted olfactory and olfactomotor performance.
  • These findings strongly implicate an olfactocerebellar pathway prominent in odor identification and detection that functionally connects each nostril primarily to the contralateral cerebellum.
  • [MeSH-major] Agnosia / physiopathology. Cerebellum / injuries. Dominance, Cerebral. Inhalation / physiology. Nasal Cavity / physiopathology. Odors. Olfaction Disorders / physiopathology. Olfactory Pathways / physiopathology. Pulmonary Ventilation / physiology
  • [MeSH-minor] Acoustic Stimulation. Adult. Age Factors. Aged. Case-Control Studies. Cerebellar Neoplasms / complications. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Dose-Response Relationship, Drug. Humans. Likelihood Functions. Magnetic Resonance Imaging. Male. Middle Aged. Sensory Thresholds. Smoking. Stroke / complications. Stroke / pathology

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  • (PMID = 16000626.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS 30256; United States / NINDS NIH HHS / NS / NS 40813
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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25. Lin M, Smith T, Beran RG: Crossed cerebellar hyperperfusion on ictal FDG PET in astrocytoma. J Clin Neurosci; 2009 Apr;16(4):603-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Crossed cerebellar hyperperfusion on ictal FDG PET in astrocytoma.
  • Crossed cerebellar hyperperfusion (CCH) is a rare phenomenon and reflects the close anatomical and functional relationship between the frontal brain region and its mediated remote effect on the contralateral cerebellum via the corticopontocerebellar pathway.
  • The scan performed shortly after seizure onset demonstrated intense metabolic activity in the right superior frontal lobe and in the contralateral cerebellar hemisphere consistent with CCH.
  • [MeSH-major] Astrocytoma / radionuclide imaging. Cerebellar Neoplasms / radionuclide imaging. Cerebellum. Cerebrovascular Circulation. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Status Epilepticus / etiology

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  • (PMID = 19231196.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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26. Akhaddar A, Belhachmi A, Elasri A, Boulahroud O, Okacha N, Elmostarshid B, Boucetta M: [Cerebellar mutism after removal of a vermian medulloblastoma in an adult]. Neurochirurgie; 2008 Aug;54(4):548-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cerebellar mutism after removal of a vermian medulloblastoma in an adult].
  • Cerebellar mutism is a rare postoperative phenomenon that generally occurs in children after resection of a cerebellar mass lesion.
  • A 22-year-old man developed cerebellar mutism after posterior fossa surgery for a mass lesion in the vermis.
  • The tumor was totally removed via a suboccipital approach.
  • Although pathophysiology and the anatomical substrate of cerebellar mutism still remain unclear, it is important that neurosurgeons be aware of this syndrome after posterior fossa surgery in adults.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Medulloblastoma / surgery. Mutism / etiology. Postoperative Complications
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures

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  • (PMID = 18495179.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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27. Szathmari A, Thiesse P, Galand-desmé S, Mottolese C, Bret P, Jouanneau E, Guyotat J, Lion-François L, Frappaz D: Correlation between pre- or postoperative MRI findings and cerebellar sequelae in patients with medulloblastomas. Pediatr Blood Cancer; 2010 Dec 15;55(7):1310-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between pre- or postoperative MRI findings and cerebellar sequelae in patients with medulloblastomas.
  • INTRODUCTION: Immediate and delayed cerebellar dysfunction may be expected after surgical resection of a medulloblastoma.
  • Magnetic Resonance Imaging (MRI) was analyzed for the following items: preoperative MRI (ratio of the surface of the tumor/posterior fossa, presence of ventricular dilatation or tonsilar hernia, involvement of the dentate nucleus) and delayed post-operative MRI (amount of cerebellar parenchyma removed, degree of cerebellar atrophy, presence of T1 hypointense regions in remaining cerebellar area and removal of region containing dentate nucleus).
  • These data were correlated with immediate and long-term cerebellar syndrome and daily life repercussions.
  • RESULTS: On preoperative MRI, the ratio of the surface of the tumor/posterior fossa and the presence of tonsilar hernia were significantly correlated with long-term sequelae on speech (respectively P = 0.027 and P = 0.05).
  • On delayed MRI, cerebellar atrophy was inversely correlated with ability to sustain daily tasks (P = 0.002).
  • Hypointense T1 territory in remaining cerebellar parenchyma significantly correlated with immediate post-operative cerebellar syndrome (P = 0.01) and showed a tendency for post-operative mutism (P = 0.087) but was not correlated with any long-term sequelae.
  • CONCLUSION: Increased cranial pressure on initial MRI and cerebellar atrophy detected on subsequent MRI studies correlated with immediate and long-term cerebellar sequelae.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Magnetic Resonance Imaging. Medulloblastoma / surgery. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Atrophy. Cerebellum / pathology. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Infant. Intracranial Hypertension / etiology. Intracranial Hypertension / pathology. Male. Young Adult

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  • (PMID = 20981689.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Chowdhury FU, Scarsbrook AF: Indium-111 pentetreotide uptake within cerebellar hemangioblastoma in von Hippel-lindau syndrome. Clin Nucl Med; 2008 Apr;33(4):294-6
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  • [Title] Indium-111 pentetreotide uptake within cerebellar hemangioblastoma in von Hippel-lindau syndrome.
  • A 38-year-old woman with known von Hippel-Lindau syndrome underwent In-111 pentetreotide (OctreoScan) scintigraphy to evaluate a suspected pancreatic neuroendocrine tumor.
  • The patient had undergone surgical resection of a left adrenal pheochromocytoma and a large right cerebellar hemangioblastoma several years previously.
  • Although there was no evidence for recurrence of pheochromocytoma and no uptake within the pancreatic lesion, there was focal tracer accumulation within the left cerebellar hemisphere.
  • MR imaging of the brain confirmed the presence of recurrent hemangioblastoma in the left cerebellum.
  • [MeSH-major] Cerebellar Neoplasms / radionuclide imaging. Hemangioblastoma / radionuclide imaging. Somatostatin / analogs & derivatives. von Hippel-Lindau Disease / radionuclide imaging
  • [MeSH-minor] Adult. Female. Humans. Radiopharmaceuticals

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  • (PMID = 18356676.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide
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29. Bedre G, Gupta T, Rajasekharan P, Munshi A, Jalali R: Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns? JOP; 2007;8(4):444-9
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  • [Title] Cerebellar, pancreatic, and paraspinal metastases in soft tissue sarcomas: unusual sites or changing patterns?
  • Cerebellar and pancreatic metastases from tumors of mesenchymal origin such as soft tissue sarcomas are exceptional, more so in the absence of pulmonary metastases.
  • An MRI brain scan was suggestive of a solitary cerebellar metastasis.
  • CONCLUSION: Cerebellar, pancreatic, and paraspinal metastases from soft tissue sarcomas are rare, especially in the absence of pulmonary metastases.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Pancreatic Neoplasms / secondary. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17625297.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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30. Till V, Koprivsek K, Stojanovic S, Avramov P, Vulekovic P: Transient cortical blindness following vertebral angiography in a young adult with cerebellar haemangioblastoma. Pediatr Radiol; 2009 Nov;39(11):1223-6
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  • [Title] Transient cortical blindness following vertebral angiography in a young adult with cerebellar haemangioblastoma.
  • We report a long episode of transient cortical blindness in a 17-year-old boy with cerebellar haemangioblastoma, which started during the preoperative vertebral angiography and lasted for 5 days.
  • Even though the patient's vision was completely restored 5 days after angiography, repeat MRI performed 2 months after angiography showed improvement but with residual lesions in the thalami, cerebellum and occipital lobe.
  • [MeSH-major] Blindness, Cortical / diagnosis. Blindness, Cortical / etiology. Brain Neoplasms / diagnosis. Cerebral Angiography / adverse effects. Hemangioblastoma / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 19779710.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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31. Richter S, Schoch B, Kaiser O, Groetschel H, Hein-Kropp C, Maschke M, Dimitrova A, Gizewski E, Ziegler W, Karnath HO, Timmann D: Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect. J Neurophysiol; 2005 Dec;94(6):4108-20
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  • [Title] Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect.
  • We studied language and visuospatial functions of 12 children and adolescents who had undergone surgery for cerebellar astrocytoma without subsequent radiation or chemotherapy and compared them with 27 age-, gender-, and education-matched healthy control subjects.
  • To study possible lateralization of the functions of the left and right cerebellar hemispheres, subjects performed several language tasks including a verb-generation task as well as standard neglect and extinction tests.
  • Three-dimensional-MR images confirmed that lesions affected cerebellar hemispheres in all children but one who had a pure vermal lesion.
  • The right cerebellar hemisphere was affected in six, the left hemisphere in four children, and both hemispheres in one child.
  • There were no signs of aphasia in the children or adolescents with cerebellar lesions.
  • Language abilities did not differ between cerebellar patients and control subjects except for small increases in reaction times in verb generation in patients with left-sided lesions.
  • Visuospatial functions were also intact in cerebellar subjects except for minor group differences in neglect tasks.
  • In sum, chronic focal cerebellar lesions acquired in childhood or youth do not result in persistent language disorders or clinically significant signs of spatial neglect or extinction.
  • [MeSH-major] Aphasia / physiopathology. Astrocytoma / physiopathology. Attention / physiology. Cerebellar Neoplasms / physiopathology. Language. Perceptual Disorders / physiopathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Brain Mapping. Case-Control Studies. Child. Dominance, Cerebral / physiology. Female. Humans. Language Tests / statistics & numerical data. Magnetic Resonance Imaging / methods. Male. Reaction Time / physiology. Space Perception / physiology. Verbal Behavior / physiology

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  • (PMID = 16033937.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Bishop FS, Liu JK, Chin SS, Fults DW: Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report. Neurosurgery; 2008 Jun;62(6):E1378-9; discussion E1379
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  • [Title] Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report.
  • OBJECTIVE: Hemangioblastomas are the most common primary intra-axial tumors of the adult posterior fossa and the tumors most often associated with von Hippel-Lindau disease.
  • Resection of cerebellar hemangioblastomas involves tumor excision and drainage of associated cysts.
  • The cyst wall is considered devoid of tumor cells and is not excised.
  • We present an unusual variant of a hemangioblastoma that showed pathological evidence of a tumor within the cyst wall that correlated with radiographic cyst wall enhancement in a patient with a recurrent hemangioblastoma.
  • CLINICAL PRESENTATION: A 38-year-old woman with von Hippel-Lindau disease presented with a recurrent cerebellar hemangioblastoma despite two previous operations during which the mural nodule was removed but the cyst wall was not.
  • Histopathological examination showed a capillary hemangioblastoma with tumor tissue inside the cyst wall.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Neoplasm Recurrence, Local / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18824960.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Konczak J, Schoch B, Dimitrova A, Gizewski E, Timmann D: Functional recovery of children and adolescents after cerebellar tumour resection. Brain; 2005 Jun;128(Pt 6):1428-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional recovery of children and adolescents after cerebellar tumour resection.
  • This study examined whether lesions to the cerebellum obtained in early childhood are better compensated than lesions in middle childhood or adolescence.
  • Since cerebellar lesions might affect motor as well a cognitive performance, posture, upper limb and working memory function were assessed in 22 patients after resection of a cerebellar tumour (age at surgery 1-17 years, minimum 3 years post-surgery).
  • Upper limb function was generally less impaired, but 54% of the patients revealed prolonged deceleration times in an arm pointing task, which probably does not reflect a genuine cerebellar deficit but rather the patients' adopted strategy to avoid overshooting.
  • We conclude that cerebellar damage inflicted at a young age is not necessarily better compensated.
  • The lesion site is critical for motor recovery, and lesions affecting the deep cerebellar nuclei are not fully compensated at any developmental age in humans.
  • [MeSH-major] Cerebellar Neoplasms / rehabilitation. Cerebellar Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Arm / physiopathology. Ataxia / etiology. Ataxia / pathology. Child. Humans. Magnetic Resonance Imaging. Memory Disorders / etiology. Memory, Short-Term. Postoperative Complications. Postoperative Period. Posture. Psychomotor Performance. Recovery of Function

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  • (PMID = 15659424.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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34. Frank B, Schoch B, Hein-Kropp C, Dimitrova A, Hövel M, Ziegler W, Gizewski ER, Timmann D: Verb generation in children and adolescents with acute cerebellar lesions. Neuropsychologia; 2007 Mar 14;45(5):977-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Verb generation in children and adolescents with acute cerebellar lesions.
  • The aim of the present study was to examine verb generation in a larger group of children and adolescents with acute focal lesions of the cerebellum.
  • Nine children and adolescents with cerebellar tumours participated.
  • Detailed analysis of individual 3D-MR images revealed that lesions affected cerebellar hemispheres in all children and adolescents.
  • The right cerebellar hemisphere was affected in four and the left hemisphere in five subjects.
  • In the present study, naming and verb generation accuracy were preserved in the majority of subjects with cerebellar lesions.
  • In sum, no significant signs of disordered verb generation were observed in children and adolescents with acute cerebellar lesions.
  • Findings suggest that the role of the cerebellum in verb generation may be less pronounced than previously suggested.
  • [MeSH-major] Cerebellar Diseases / complications. Cerebellum / physiology. Dysarthria / complications. Language Disorders / etiology. Verbal Behavior / physiology. Vocabulary
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Cerebellar Neoplasms / complications. Cerebellar Neoplasms / surgery. Child. Female. Functional Laterality / physiology. Humans. Language Tests. Male. Matched-Pair Analysis. Reaction Time / physiology. Reference Values. Verbal Learning / physiology

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  • (PMID = 17030046.001).
  • [ISSN] 0028-3932
  • [Journal-full-title] Neuropsychologia
  • [ISO-abbreviation] Neuropsychologia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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35. Paslawski T, Duffy JR, Vernino S: Speech and language findings associated with paraneoplastic cerebellar degeneration. Am J Speech Lang Pathol; 2005 Aug;14(3):200-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Speech and language findings associated with paraneoplastic cerebellar degeneration.
  • Paraneoplastic cerebellar degeneration (PCD) is an autoimmune disease that can be associated with cancer of the breast, lung, and ovary.
  • While ataxic dysarthria was the most common speech diagnosis, a spastic component was recognized frequently enough to suggest that the subacute (days to weeks) emergence and progression of an ataxic or mixed ataxic-spastic dysarthria in the setting of a more diffuse cerebellar ataxia should raise suspicions about PCD and justify further investigation of a possible immune-related etiology.

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  • (PMID = 16229671.001).
  • [ISSN] 1058-0360
  • [Journal-full-title] American journal of speech-language pathology
  • [ISO-abbreviation] Am J Speech Lang Pathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / PCA-1 antigen, human
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36. Tatke M, Singh AK: Cerebellar liponeurocytoma--a case report. Indian J Pathol Microbiol; 2005 Jan;48(1):29-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar liponeurocytoma--a case report.
  • Cerebellar liponeurocytomas have been included in the 2000 classification of tumours of the central nervous system, under the heading of glioneuronal tumours.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Lipoma / pathology. Neurocytoma / pathology
  • [MeSH-minor] Adult. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Synaptophysin / metabolism

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  • (PMID = 16758783.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Synaptophysin
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37. Ueba T, Kadota E, Kano H, Yamashita K, Kageyama N: MATH-1 production by an adult medulloblastoma suggestive of a cerebellar external granule cell precursor origin. J Clin Neurosci; 2008 Jan;15(1):84-7
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  • [Title] MATH-1 production by an adult medulloblastoma suggestive of a cerebellar external granule cell precursor origin.
  • Radiological, histological and molecular findings in an uncommon adult case of cerebellar medulloblastoma suggested an external granular cell precursor origin.
  • Neuroimaging studies demonstrated a homogeneously enhanced well-circumscribed mass lesion in the right cerebellar hemisphere and she underwent surgery.
  • Postoperative neuronal imaging studies showed that the tumor located in the cerebellar folia had been removed totally.
  • Polymerase chain reaction and immunohistochemical findings revealed the presence of MATH-1, expressed in cerebellar external granule cell precursors during fetal development, in the tumor cells.
  • These findings suggest that the tumor arose from external granule cell precursors of the cerebellum and that it was therefore of neuronal lineage.
  • [MeSH-major] Basic Helix-Loop-Helix Transcription Factors / metabolism. Cerebellar Neoplasms / metabolism. Cerebellar Neoplasms / pathology. Medulloblastoma / metabolism. Medulloblastoma / pathology. Neurons / physiology
  • [MeSH-minor] Adult. Female. Gene Expression Regulation, Neoplastic. Humans. Magnetic Resonance Imaging / methods. Neoplastic Stem Cells / physiology. Phosphopyruvate Hydratase / metabolism

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  • (PMID = 18032051.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / ATOH1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; EC 4.2.1.11 / Phosphopyruvate Hydratase
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38. Gyure KA: Newly defined central nervous system neoplasms. Am J Clin Pathol; 2005 Jun;123 Suppl:S3-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Newly defined central nervous system neoplasms.
  • In recent years, numerous new entities or variants of recognized central nervous system tumors have been described in the literature, and the morphologic spectrum of these neoplasms is delineated incompletely.
  • The clinicopathologic features and differential diagnosis of 4 new entities, including the chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and papillary glioneuronal tumor, are discussed in this review.
  • [MeSH-major] Central Nervous System Neoplasms / classification. Central Nervous System Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cerebellar Neoplasms / classification. Cerebellar Neoplasms / diagnosis. Child. Chordoma / classification. Chordoma / diagnosis. Diagnosis, Differential. Female. Ganglioglioma / classification. Ganglioglioma / diagnosis. Glioma / diagnosis. Glioma / pathology. Humans. Hypothalamic Neoplasms / classification. Hypothalamic Neoplasms / diagnosis. Male. Medulloblastoma / classification. Medulloblastoma / diagnosis. Prognosis. Rhabdoid Tumor / classification. Rhabdoid Tumor / diagnosis. Teratoma / classification. Teratoma / diagnosis. Third Ventricle / pathology

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  • (PMID = 16100866.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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39. Kawarabuki K, Ohta T, Hashimoto N, Wada K, Maruno M, Yamaki T, Ueda S: Cerebellar glioblastoma genetically defined as a secondary one. Clin Neuropathol; 2005 Mar-Apr;24(2):64-8
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  • [Title] Cerebellar glioblastoma genetically defined as a secondary one.
  • We report here the case of a 29-year-old woman with cerebellar glioblastma.
  • In the present case, tumor lesions were observed in each cerebellar hemisphere.
  • Immunohistochemistry revealed that the tumor cells of the left-side lesion was positive for p53, whereas epidermal growth factor receptors (EGFR) were negative in tumor cells from both sides.
  • Genetic alterations were investigated using a genome DNA microarray (GenoSensor Array 300), which has led us to define this tumor as a secondary glioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Glioblastoma / genetics. Neoplasms, Second Primary / genetics
  • [MeSH-minor] Adult. Female. Humans. Oligonucleotide Array Sequence Analysis

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  • (PMID = 15803805.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Ilg W, Giese MA, Gizewski ER, Schoch B, Timmann D: The influence of focal cerebellar lesions on the control and adaptation of gait. Brain; 2008 Nov;131(Pt 11):2913-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The influence of focal cerebellar lesions on the control and adaptation of gait.
  • Cerebellar ataxic gait is influenced greatly by balance disorders, most likely caused by lesions of the medial zone of the cerebellum.
  • In this study, we analysed locomotion and goal-directed leg movements in 12 patients with chronic focal lesions after resection of benign cerebellar tumours.
  • The extent of the cortical lesion and possible involvement of the cerebellar nuclei was determined by 3D-MR imaging.
  • [MeSH-major] Cerebellar Nuclei / physiopathology. Gait Ataxia / physiopathology
  • [MeSH-minor] Adaptation, Physiological. Adolescent. Adult. Brain Mapping / methods. Cerebellar Neoplasms / surgery. Female. Gait. Humans. Leg / physiopathology. Magnetic Resonance Imaging / methods. Male. Movement. Postoperative Complications / pathology. Postoperative Complications / physiopathology. Postural Balance. Psychomotor Performance. Walking. Weight-Bearing. Young Adult

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  • (PMID = 18835866.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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41. Jagannathan J, Lonser RR, Smith R, DeVroom HL, Oldfield EH: Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg; 2008 Feb;108(2):210-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease.
  • OBJECT: Despite the frequency of cerebellar hemangioblastomas in von Hippel-Lindau (VHL) disease, their optimum contemporary management has not been defined, and is made complex because of the multiple, progressive, and protean nature of the tumors found in patients with this disorder.
  • To examine modern management and outcomes of cerebellar hemangioblastomas in VHL disease, the authors reviewed findings in patients with this disease who underwent resection of cerebellar hemangioblastomas.
  • METHODS: Consecutive patients with VHL disease who underwent surgery for cerebellar hemangioblastoma(s) at the National Institutes of Health were included.
  • Eighty consecutive patients (44 female and 36 male patients) underwent 126 operations for removal of 164 cerebellar hemangioblastomas (age at surgery 37.8+/-10.3 years, follow-up duration 96.0+/-60.3 months).
  • Tumors associated with symptoms were larger (diameter 1.8+/-1.9 cm; volume 2.8+/-3.4 cm3; p<0.05) and more likely to be associated with peritumoral edema or peritumoral cysts (100% associated with edema and/or cyst; p<0.05) than asymptomatic tumors (diameter 1.1+/-0.9 cm; volume 0.7+/-0.4 cm3; 18%).
  • More tumors were located in the posterior (74%) compared with the anterior (26%) half of the cerebellum (p<0.05).
  • Preoperative hydrocephalus resolved after tumor removal in 33 cases (94%) and did not require cerebrospinal fluid diversion.
  • CONCLUSIONS: Symptoms and signs caused by cerebellar hemangioblastomas in VHL disease are associated with edema and peritumoral cyst formation/propagation and are treated safely and effectively with resection.
  • Cerebrospinal fluid diversion is rarely necessary after complete tumor removal in patients with preoperative hydrocephalus.
  • Cerebellar hemangioblastomas are preferentially distributed in the posterior half of the cerebellum, as they are in the brainstem and spinal cord.
  • Tumor recurrence is avoided by meticulous extracapsular resection.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Ataxia / physiopathology. Brain Edema / physiopathology. Cerebellar Ataxia / physiopathology. Cranial Irradiation. Cysts / physiopathology. Dissection / methods. Electrocoagulation / methods. Female. Follow-Up Studies. Headache / physiopathology. Humans. Hydrocephalus / physiopathology. Male. Microdissection / methods. Postoperative Complications. Radiosurgery. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 18240914.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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42. Urbański J, Mucha-Małecka A, Gliński B: [Cerebellar metastasis from ovarian carcinoma. A case report]. Ginekol Pol; 2005 Jun;76(6):481-3
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  • [Title] [Cerebellar metastasis from ovarian carcinoma. A case report].
  • This report presents an unusual case of 40-year-old woman with complete locoregional remission of ovarian carcinoma, presented with a single cerebellar metastasis.
  • Surgical excision of the cerebellar lesion, followed by brain irradiation, resulted in complete resolution of her symptoms.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Cerebellar Neoplasms / therapy. Cystadenocarcinoma / secondary. Cystadenocarcinoma / therapy. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Treatment Outcome

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  • (PMID = 16149267.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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43. Hayashi S, Takeda N, Komura E: Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report. Neurol Med Chir (Tokyo); 2010;50(12):1105-7
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  • [Title] Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report.
  • A 30-year-old woman suffered cerebellar hemorrhage during the delivery of her first child.
  • She had undergone surgical removal of a symptomatic cerebellar hemangioblastoma 6 years previously.
  • Hemangioblastomas are benign tumors that are curable with surgical removal, but can grow during pregnancy.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellum / blood supply. Hemangioblastoma / complications. Intracranial Hemorrhages / etiology. Neoplasm Recurrence, Local / complications
  • [MeSH-minor] Adult. Cerebral Angiography. Female. Humans. Obstetric Labor Complications / etiology. Pregnancy. Pregnancy Complications, Neoplastic / pathology. Pregnancy Complications, Neoplastic / surgery. Treatment Outcome

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  • (PMID = 21206188.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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44. Chamberlain MC: Risk of neoplastic meningitis following surgical resection of cerebellar metastases. J Neurooncol; 2008 Aug;89(1):105-7
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  • [Title] Risk of neoplastic meningitis following surgical resection of cerebellar metastases.
  • BACKGROUND: Based on limited literature, an at risk group of patients for development of neoplastic meningitis (NM) are those with resected cerebellar parenchymal metastases.
  • OBJECTIVE: Characterize the incidence of NM in patients with cerebellar metastases treated with either surgical resection or radiotherapy.
  • PATIENTS AND METHODS: A retrospective study to determine outcome and in particular the occurrence of NM in 30 patients with resected cerebellar metastases (Group 1) and in 50 patients with cerebellar metastases treated with radiotherapy only (Group 2).
  • Additionally, 10 patients with coincident cerebellar metastases and NM were identified (Group 3) and compared with these groups.
  • CONCLUSIONS: The incidence of NM following resection of cerebellar metastases (3%: Group 1) was no greater than that seen following treatment of cerebellar metastases with radiotherapy only (2%; Group 2).
  • In addition, in a large data base of patients with NM (40% with parenchymal metastases), cerebellar metastases occurred at a proportion (10%; Group 3) expected based on proportional brain volume and cerebral blood flow.
  • [MeSH-major] Cerebellar Neoplasms / epidemiology. Cerebellum / pathology. Cerebellum / surgery. Meningitis, Aseptic / epidemiology
  • [MeSH-minor] Adult. Aged. Comorbidity. Humans. Incidence. Meninges / pathology. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Neurosurgical Procedures / adverse effects. Retrospective Studies. Risk Factors. Survival Rate

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  • (PMID = 18438610.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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45. Shoman N, Longridge N: Cerebellar vermis lesions and tumours of the fourth ventricle in patients with positional and positioning vertigo and nystagmus. J Laryngol Otol; 2007 Feb;121(2):166-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar vermis lesions and tumours of the fourth ventricle in patients with positional and positioning vertigo and nystagmus.
  • We draw attention to the diagnosis of cerebellar vermis lesions and tumours of the fourth ventricle by presenting two cases of patients with positional nystagmus of so called benign paroxysmal type.
  • [MeSH-major] Cerebellar Neoplasms / complications. Nystagmus, Pathologic / etiology. Vertigo / etiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Treatment Outcome

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  • (PMID = 17059627.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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46. Maryniak A, Roszkowski M: [Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors]. Neurol Neurochir Pol; 2005 May-Jun;39(3):202-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors].
  • BACKGROUND AND PURPOSE: The cerebellum has been associated with motor control, but more recent studies have extended its contribution to other functions, such as modulation of emotions, behavioral organization or language.
  • The cerebellar cognitive affective syndrome was described primarily in adults.
  • In children, cerebellar lesions are relatively frequent and some are due to neoplasm.
  • MATERIAL AND METHODS: Cognitive and emotional functions were studied in 66 children who underwent surgery for cerebellar pilocytic astrocytoma at the Department of Neurosurgery of the Children Memorial Health Institute.
  • No significant differences between groups of children with different localization of tumor (vermis or cerebellar hemisphere) were observed.
  • CONCLUSIONS: The present study confirms the psychological deficits following cerebellar lesion in children, similar to the cerebellar cognitive affective syndrome reported in adult patients.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Cognition Disorders / etiology. Mood Disorders / etiology. Neurosurgical Procedures / adverse effects. Speech Disorders / etiology
  • [MeSH-minor] Adaptation, Psychological. Adolescent. Adult. Cerebellum / physiopathology. Cerebellum / surgery. Child. Child, Preschool. Female. Humans. Male. Memory Disorders / etiology. Neuropsychological Tests. Parent-Child Relations. Poland. Retrospective Studies

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  • (PMID = 15981157.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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47. Ypma PF, Wijermans PW, Koppen H, Sillevis Smitt PA: Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma. Neth J Med; 2006 Jul-Aug;64(7):243-7
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  • [Title] Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma.
  • Paraneoplastic cerebellar degeneration (PCD) can present as a severe and (sub)acute cerebellar syndrome.
  • PCD can accompany different kinds of neoplasms including small cell lung cancer, adenocarcinoma of the breast and ovary, and Hodgkin's lymphoma.
  • Despite extensive laboratory and radiological evaluations in this patient with rapidly deteriorating cerebellar syndrome, the diagnosis of a paraneoplastic syndrome was only made after several months, when an anti-Tr antibody was detected in his serum.
  • After starting therapy the cerebellar degeneration stabilised.
  • Improvement of the cerebellar syndrome in anti-Tr autoantibody paraneoplastic disease is a rare achievement.
  • [MeSH-major] Cerebellum / pathology. Hodgkin Disease / diagnosis. Paraneoplastic Cerebellar Degeneration / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Dexamethasone / administration & dosage. Etoposide / administration & dosage. Humans. Male. Neoplasm Staging. Positron-Emission Tomography. Radiotherapy, Adjuvant. Remission Induction. Tomography, X-Ray Computed. Vinblastine / administration & dosage


48. Chen Y, Tachibana O, Hasegawa M, Xu R, Hamada J, Yamashita J, Hashimoto N, Takahashi JA: Absence of tight junctions between microvascular endothelial cells in human cerebellar hemangioblastomas. Neurosurgery; 2006 Sep;59(3):660-70; discussion 660-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of tight junctions between microvascular endothelial cells in human cerebellar hemangioblastomas.
  • METHODS: Twenty-four consecutive patients with cerebellar hemangioblastomas were studied.
  • CONCLUSION: The continuity of tight junctions of the BBB is interrupted in human cerebellar hemangioblastomas.
  • Significant absence of astrocytic endfeet and tight junctions can be found in microvessels of hemangioblastomas, which may lead to the breakdown of the BBB in these tumors.
  • [MeSH-major] Blood-Brain Barrier / ultrastructure. Cerebellar Neoplasms / pathology. Endothelial Cells / ultrastructure. Hemangioblastoma / pathology. Tight Junctions / ultrastructure
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16955048.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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49. Cornelius JF, Saint-Maurice JP, Bresson D, George B, Houdart E: Hemorrhage after particle embolization of hemangioblastomas: comparison of outcomes in spinal and cerebellar lesions. J Neurosurg; 2007 Jun;106(6):994-8
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  • [Title] Hemorrhage after particle embolization of hemangioblastomas: comparison of outcomes in spinal and cerebellar lesions.
  • OBJECT: In this study the authors compare the clinical outcomes after particle embolization of hemangioblastomas in the cerebellum and spinal cord.
  • METHODS: Seven patients with hemangioblastomas in the spinal cord (four patients) and cerebellum (three patients) underwent preoperative embolization at the authors' center.
  • The outcome of embolization was favorable in patients with spinal cord hemangioblastomas, but it was unfavorable for those with cerebellar hemangioblastomas; acute tumor bleeding and death occurred in all of the latter cases.
  • CONCLUSIONS: The authors no longer use particle embolization to treat cerebellar hemangioblastomas.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Cerebral Hemorrhage / etiology. Embolization, Therapeutic / adverse effects. Hemangioblastoma / therapy. Postoperative Complications / etiology. Spinal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Cerebral Angiography. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Particle Size. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2008 May;108(5):1063-4; author reply 1064-5 [18447734.001]
  • (PMID = 17564170.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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50. Schoch B, Hogan A, Gizewski ER, Timmann D, Konczak J: Balance control in sitting and standing in children and young adults with benign cerebellar tumors. Cerebellum; 2010 Sep;9(3):324-35
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  • [Title] Balance control in sitting and standing in children and young adults with benign cerebellar tumors.
  • Children and young adolescents with chronic surgical cerebellar lesions show persistent balance control problems during standing when lesions affect the deep cerebellar fastigial and adjacent interposed nuclei.
  • Balance control was assessed in 16 patients after surgery of a benign cerebellar tumor in chronic state and healthy age- and gender-matched control subjects.
  • High-resolution MRI scans were acquired in the cerebellar patients.
  • During sitting, 56% of cerebellar patients exhibited trunkal sway outside the range of healthy controls, and 87.5% of cerebellar patients revealed abnormal sway patterns during standing.
  • In patients with surgery <1-year lesions of the inferior cerebellar vermis also had an impact on balance function.
  • Our results corroborate previous evidence that the extent of permanent damage to the deep cerebellar nuclei greatly impacts on the recovery on balance function.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Neurosurgical Procedures / adverse effects. Postoperative Complications / physiopathology. Postural Balance
  • [MeSH-minor] Adolescent. Adult. Biomechanical Phenomena. Cerebellum / pathology. Cerebellum / physiopathology. Cerebellum / surgery. Child. Female. Humans. Male. Posture. Young Adult

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  • (PMID = 20352395.001).
  • [ISSN] 1473-4230
  • [Journal-full-title] Cerebellum (London, England)
  • [ISO-abbreviation] Cerebellum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Imgrund S, Hartmann D, Farwanah H, Eckhardt M, Sandhoff R, Degen J, Gieselmann V, Sandhoff K, Willecke K: Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem; 2009 Nov 27;284(48):33549-60
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  • [Title] Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.
  • Starting around 9 months, both the medullary tree and the internal granular layer of the cerebellum show significant signs of degeneration associated with the formation of microcysts.
  • Our results indicate that CERS2 activity supports different biological functions: maintenance of myelin, stabilization of the cerebellar as well as renal histological architecture, and protection against hepatocarcinomas.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Myelin Sheath / pathology. Oxidoreductases / deficiency. Sphingosine N-Acyltransferase / metabolism. Spinocerebellar Degenerations / pathology

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  • (PMID = 19801672.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ceramides; 0 / Sphingolipids; 0 / Sphingomyelins; EC 1.- / Oxidoreductases; EC 1.3.1.- / dihydroceramide desaturase; EC 2.3.1.24 / Sphingosine N-Acyltransferase
  • [Other-IDs] NLM/ PMC2785198
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52. Kasliwal MK, Suri A, Rishi A, Suri V, Sharma BS, Sarkar C: Symptomatic bilateral cerebellar mass lesions: an unusual presentation of intracranial xanthogranuloma. J Clin Neurosci; 2008 Dec;15(12):1401-4
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  • [Title] Symptomatic bilateral cerebellar mass lesions: an unusual presentation of intracranial xanthogranuloma.
  • Multicentric bilateral symptomatic cerebellar xanthogranuloma has not been reported previously.
  • We describe a 35-year-old man who presented with a complaint of vertigo, with nystagmus and left-side cerebellar signs found on clinical examination.
  • Radiological evaluation revealed bilateral cerebellar lesions abutting the cerebellopontine angle cistern.
  • The role of histopathology cannot be overemphasized in the diagnosis of this rare lesion and long-term follow-up is advised in cases managed conservatively owing to the propensity of this tumor to grow over time.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Granuloma / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 18952438.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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53. Sakaura H, Hosono N, Mukai Y, Ishii T, Yoshikawa H: Multiple cerebellar hemorrhagic infarctions following surgery for a huge atlantoaxial neurinoma. Spine J; 2006 Jan-Feb;6(1):86-9
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  • [Title] Multiple cerebellar hemorrhagic infarctions following surgery for a huge atlantoaxial neurinoma.
  • BACKGROUND CONTEXT: There have been only five reported cases with cerebellar hemorrhagic infarction after spinal surgery, and the underlying pathomechanism remains obscure.
  • PURPOSE: To describe a case with multiple cerebellar hemorrhagic infarctions after surgery for a huge atlantoaxial neurinoma.
  • After surgery, the patient was lethargic with slurred speech and subsequently developed cerebellar symptoms, although preoperative myelopathic symptoms did not worsen.
  • RESULTS: Magnetic resonance imaging of the brain after surgery showed multiple cerebellar hemorrhagic infarctions.
  • In response to the conservative treatment, the patient exhibited neurological recovery with disappearance of cerebellar symptoms.
  • CONCLUSIONS: In the present case with multiple cerebellar hemorrhagic infarctions, venous infarction appears more likely to be the cause of cerebellar hemorrhagic infarction than arterial infarction.
  • The most likely underlying pathomechanism is a cerebellar venous disturbance precipitated by loss of a large amount of cerebrospinal fluid, although the exact etiology remains elusive.
  • [MeSH-major] Brain Infarction / etiology. Cerebellar Diseases / etiology. Laminectomy / adverse effects. Neurilemmoma / surgery. Postoperative Complications / diagnosis. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Atlanto-Axial Joint. Follow-Up Studies. Humans. Magnetic Resonance Angiography. Male. Neoplasm Staging. Risk Assessment

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  • (PMID = 16413453.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Akar S, Drappatz J, Hsu L, Blinder RA, Black PM, Kesari S: Hypertrophic olivary degeneration after resection of a cerebellar tumor. J Neurooncol; 2008 May;87(3):341-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypertrophic olivary degeneration after resection of a cerebellar tumor.
  • We report a case of hypertrophic olivary degeneration due to cerebellar surgery for a low-grade tumor.
  • A 27-year-old female presented with right-sided paresthesias and intermittent leg paresis following a right cerebellar resection of a tumor 2 weeks prior.
  • Hypertrophic olivary degeneration may be mistaken for tumor progression, post-operative vasculopathy or granulation tissue and should be considered in patients undergoing cerebellar surgery.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Neurosurgical Procedures / adverse effects. Olivary Nucleus / pathology
  • [MeSH-minor] Adult. Ataxia / etiology. Diagnosis, Differential. Female. Humans. Hypertrophy. Hypesthesia / etiology. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18217209.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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55. de Ribaupierre S, Ryser C, Villemure JG, Clarke S: Cerebellar lesions: is there a lateralisation effect on memory deficits? Acta Neurochir (Wien); 2008 Jun;150(6):545-50; discussion 550

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar lesions: is there a lateralisation effect on memory deficits?
  • BACKGROUND: Until recently, neurosurgeons eagerly removed cerebellar lesions without consideration of future cognitive impairment that might be caused by the resection.
  • In children, transient cerebellar mutism after resection has lead to a diminished use of midline approaches and vermis transection, as well as reduced retraction of the cerebellar hemispheres.
  • The role of the cerebellum in higher cognitive functions beyond coordination and motor control has recently attracted significant interest in the scientific community, and might change the neurosurgical approach to these lesions.
  • The aim of this study was to investigate the specific effects of cerebellar lesions on memory, and to assess a possible lateralisation effect.
  • METHODS: We studied 16 patients diagnosed with a cerebellar lesion, from January 1997 to April 2005, in the "Centre Hospitalier Universitaire Vaudois (CHUV)", Lausanne, Switzerland.
  • RESULTS: Severe memory deficits in at least one modality were identified in a majority (81%) of patients with cerebellar lesions.
  • FINDINGS: These findings are consistent with findings in the literature concerning memory deficits in isolated cerebellar lesions.
  • The high percentage of patients with a cerebellar lesion who demonstrate memory deficits should lead us to assess memory in all patients with cerebellar lesions.
  • [MeSH-major] Amnesia / physiopathology. Cerebellar Neoplasms / physiopathology. Dominance, Cerebral / physiology
  • [MeSH-minor] Adolescent. Adult. Aged. Amnesia, Anterograde / diagnosis. Amnesia, Anterograde / physiopathology. Astrocytoma / diagnosis. Astrocytoma / physiopathology. Astrocytoma / surgery. Cerebellum / physiopathology. Cerebellum / surgery. Female. Follow-Up Studies. Glioblastoma / diagnosis. Glioblastoma / physiopathology. Glioblastoma / surgery. Hemangioblastoma / diagnosis. Hemangioblastoma / physiopathology. Hemangioblastoma / surgery. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / physiopathology. Hemangioma, Cavernous / surgery. Humans. Male. Medulloblastoma / diagnosis. Medulloblastoma / physiopathology. Medulloblastoma / surgery. Memory, Short-Term / physiology. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / physiopathology. Meningeal Neoplasms / surgery. Meningioma / diagnosis. Meningioma / physiopathology. Meningioma / surgery. Middle Aged. Neuropsychological Tests. Postoperative Complications / diagnosis. Postoperative Complications / physiopathology. Verbal Learning / physiology

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  • (PMID = 18512000.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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56. Nadkarni TD, Menon RK, Desai KI, Goel AH: Cerebellar oligodendroglioma in a young adult. J Clin Neurosci; 2005 Sep;12(7):837-8
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  • [Title] Cerebellar oligodendroglioma in a young adult.
  • A rare case of an oligodendroglioma of the cerebellum in an 18-year-old male is presented.
  • [MeSH-major] Cerebellar Neoplasms. Oligodendroglioma

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  • (PMID = 16169228.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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57. Patrick TA, Giannini C, Ebersold MJ, Link MJ: Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report. J Neurosurg; 2006 Mar;104(3):452-6
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  • [Title] Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report.
  • Metastatic seeding or iatrogenic implantation of numerous types of primary central nervous system tumors, typically along cerebrospinal fluid pathways, is a frequently described albeit rare phenomenon and has never been reported in association with vestibular schwannoma (VS).
  • The authors present a case of inadvertent surgical implantation of VS into the cerebellar hemisphere during resection of a recurrent VS in the cerebellopontine angle and internal auditory canal.
  • Five years later--10 years after initial presentation--follow-up imaging revealed a 1-cm recurrence of the VS and a separate 2.2-cm tumor in the inferior cerebellar parenchyma with surrounding edema.
  • Both tumors were removed without complication by reopening the previous retrosigmoid craniotomy.
  • Histological evaluation of these tumors revealed features typical of VS and similar to those of the tissue obtained from the two prior resections.
  • Given the similarities among these tumors in pathological appearance and mitotic index, the presence of the intraparenchymal cerebellar schwannoma was probably due to intraoperative iatrogenic implantation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Neuroma, Acoustic / etiology
  • [MeSH-minor] Adult. Cerebellopontine Angle / pathology. Humans. Iatrogenic Disease. Male. Mitotic Index. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16572663.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Naeije G, de Hemptinne Q, Depondt C, Pandolfo M, Legros B: Acute behavioural change in a young woman evolving towards cerebellar syndrome. Clin Neurol Neurosurg; 2010 Jul;112(6):509-11
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  • [Title] Acute behavioural change in a young woman evolving towards cerebellar syndrome.
  • The remaining sequellae included a cerebellar syndrome seldom described before.
  • As cerebellar and cortical neurons share the same excitatory pathway through NMDA-glutamate receptors, the cerebellar function impairment observed in our patient could be explained by a disabling action on glutamate NMDAR by the A-NMDAR.
  • [MeSH-major] Autoantibodies / immunology. Autoimmune Diseases / immunology. Autoimmune Diseases / psychology. Paraneoplastic Cerebellar Degeneration / psychology. Receptors, N-Methyl-D-Aspartate / immunology
  • [MeSH-minor] Adult. Behavior. Brain Chemistry / physiology. Coma / etiology. Coma / psychology. Delirium / etiology. Delirium / psychology. Female. Humans. Magnetic Resonance Imaging. Ovarian Neoplasms / complications. Ovarian Neoplasms / surgery. Positron-Emission Tomography. Psychomotor Agitation / psychology. Teratoma / complications. Teratoma / surgery

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20347215.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Receptors, N-Methyl-D-Aspartate
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59. Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD: The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res; 2009 Apr 15;69(8):3249-55
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  • [Title] The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.
  • Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood.
  • Consistent with its regulation by Shh, we observed that Shh treatment of primary cerebellar granule neuron precursors (CGNP), proposed cells of origin for the Shh-associated medulloblastomas, resulted in increased miR-17/92 expression.

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  • (PMID = 19351822.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS061070-01; United States / NINDS NIH HHS / NS / R01 NS061070; United States / NINDS NIH HHS / NS / R01 NS061070-01; United States / NINDS NIH HHS / NS / R01NS061070
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / MIRN17 microRNA, human; 0 / MicroRNAs; 0 / Proto-Oncogene Proteins c-myc; 0 / SHH protein, human
  • [Other-IDs] NLM/ NIHMS100132; NLM/ PMC2836891
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60. Schweizer TA, Alexander MP, Susan Gillingham BA, Cusimano M, Stuss DT: Lateralized cerebellar contributions to word generation: a phonemic and semantic fluency study. Behav Neurol; 2010;23(1-2):31-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lateralized cerebellar contributions to word generation: a phonemic and semantic fluency study.
  • Impairment on verbal fluency tasks has been one of the more consistently reported neuropsychological findings after cerebellar lesions, but it has not been uniformly observed and the possible underlying cognitive basis has not been investigated.
  • We tested twenty-two patients with chronic, unilateral cerebellar lesions (12 Left, 10 Right) and thirty controls on phonemic and semantic fluency tasks.
  • In the phonemic fluency task, the right cerebellar lesion (RC) group produced significantly fewer words compared to the left cerebellar lesion (LC) group and healthy controls, particularly over the first 15 seconds of the task with no increase in errors and significantly fewer switches over the entire task.
  • This supports the hypotheses of a prefrontal-lateral cerebellar system for modulation of attention/executive or strategy demanding tasks.
  • [MeSH-major] Cerebellum / physiology. Functional Laterality / physiology. Speech / physiology. Verbal Behavior / physiology
  • [MeSH-minor] Adult. Aged. Brain Hemorrhage, Traumatic / physiopathology. Brain Hemorrhage, Traumatic / psychology. Cerebellar Diseases / physiopathology. Cerebellar Diseases / psychology. Cerebellar Neoplasms / surgery. Executive Function / physiology. Female. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Middle Aged. Neuropsychological Tests. Phonetics. Semantics. Stroke / complications. Young Adult

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  • (PMID = 20714059.001).
  • [ISSN] 1875-8584
  • [Journal-full-title] Behavioural neurology
  • [ISO-abbreviation] Behav Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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61. Mano Y, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T: [A case report of cerebellar pleomorphic xanthoastrocytoma]. No Shinkei Geka; 2009 Jun;37(6):586-90
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  • [Title] [A case report of cerebellar pleomorphic xanthoastrocytoma].
  • Pleomorphic xanthoastrocytoma (PXA) is a type of astrocytic neoplasm, classified as WHO grade II, which mainly occurs supratentorially, and rarely infratentorially.
  • We report an unusual case of PXA in the cerebellar vermis.
  • Magnetic resonance imaging and computed tomography demonstrated a mass lesion with cyst in the cerebellar vermis.
  • The histological diagnosis was PXA of the cerebellar vermis.
  • This case suggests that PXA should be considered in the differential diagnosis of cystic lesion in the cerebellar vermis.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19522287.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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62. Kirschen MP, Davis-Ratner MS, Milner MW, Chen SH, Schraedley-Desmond P, Fisher PG, Desmond JE: Verbal memory impairments in children after cerebellar tumor resection. Behav Neurol; 2008;20(1-2):39-53
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  • [Title] Verbal memory impairments in children after cerebellar tumor resection.
  • This study was designed to investigate cerebellar lobular contributions to specific cognitive deficits observed after cerebellar tumor resection.
  • Verbal working memory (VWM) tasks were administered to children following surgical resection of cerebellar pilocytic astrocytomas and age-matched controls.
  • Anatomical MRI scans were used to quantify the extent of cerebellar lobular damage from each patient's resection.
  • These data corroborate neuroimaging studies showing focal cerebellar activation during VWM paradigms, and thereby allow us to predict with greater accuracy which specific neurocognitive processes will be affected by a cerebellar tumor resection.

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  • (PMID = 19491473.001).
  • [ISSN] 0953-4180
  • [Journal-full-title] Behavioural neurology
  • [ISO-abbreviation] Behav Neurol
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / MH060234-08; United States / NIMH NIH HHS / MH / R01 MH060234; United States / NIMH NIH HHS / MH / MH060234; United States / NIMH NIH HHS / MH / R01 MH060234-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS124119; NLM/ PMC2745108
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63. Brockmann MA, Nowak G, Reusche E, Russlies M, Petersen D: Zebra sign: cerebellar bleeding pattern characteristic of cerebrospinal fluid loss. Case report. J Neurosurg; 2005 Jun;102(6):1159-62
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  • [Title] Zebra sign: cerebellar bleeding pattern characteristic of cerebrospinal fluid loss. Case report.
  • Less often, spinal or supratentorial interventions cause remote cerebellar hemorrhage (RCH).
  • Hemorrhage is often characterized by a typical, streaky bleeding pattern due to blood spreading in the cerebellar sulci.
  • [MeSH-minor] Acute Disease. Adult. Cerebellum / blood supply. Female. Humans. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Pancoast Syndrome / surgery. Spinal Diseases / surgery

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  • (PMID = 16028781.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Brewis S, Baguley DM: Management of tinnitus induced by brainstem and cerebellar infarction associated with complications of cerebello-pontine angle surgery. J Laryngol Otol; 2007 Apr;121(4):393-4
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  • [Title] Management of tinnitus induced by brainstem and cerebellar infarction associated with complications of cerebello-pontine angle surgery.
  • Following surgery in the USA in 1992 to remove a large right cerebello-pontine angle tumour, a 39-year-old woman developed severe brainstem and cerebellar infarction.
  • [MeSH-major] Brain Stem Infarctions / complications. Cerebellar Neoplasms / complications. Cerebellopontine Angle. Cerebral Infarction / complications. Meningioma / complications. Tinnitus / etiology
  • [MeSH-minor] Adult. Female. Hearing Aids. Hearing Loss / etiology. Humans. Treatment Outcome

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  • (PMID = 17403265.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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65. Abo-Al Hassan A, Ismail M, Panda SM: Pre-operative endovascular embolization of a cerebellar haemangioblastoma. A case report. Med Princ Pract; 2006;15(6):459-62
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  • [Title] Pre-operative endovascular embolization of a cerebellar haemangioblastoma. A case report.
  • OBJECTIVE: To present an interesting case of pre-operative embolization of a cerebellar haemangioblastoma.
  • MRI of the brain revealed a right cerebellar solid mass and cerebral angiography demonstrated its extensive hypervascular nature.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Embolization, Therapeutic / methods. Hemangioblastoma / therapy
  • [MeSH-minor] Adult. Humans. Male. Polyvinyl Alcohol / therapeutic use

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  • (PMID = 17047356.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 9002-89-5 / Polyvinyl Alcohol
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66. Fukushima S, Terasaki M, Tajima Y, Shigemori M: Granulocytic sarcoma: an unusual complication of acute promyelocytic leukemia causing cerebellar hemorrhage. Case report. J Neurosurg; 2006 Dec;105(6):912-5
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  • [Title] Granulocytic sarcoma: an unusual complication of acute promyelocytic leukemia causing cerebellar hemorrhage. Case report.
  • Granulocytic sarcomas are rare tumors that occur primarily in patients with acute myelogenous leukemia or other myeloproliferative disorders, are seldom seen in patients with acute promyelocytic leukemia (APL), and have never been reported to occur in the cerebellum.
  • The authors describe the case of a patient with APL who harbored a hemorrhagic granulocytic sarcoma in the cerebellum.
  • This 39-year-old woman presented with cerebellar ataxia.
  • Magnetic resonance images revealed an intraaxial tumor in the cerebellum.
  • Results of histopathological studies and immunohistochemical staining of the cerebellar tumor confirmed a granulocytic sarcoma.
  • This is the first report to document a granulocytic sarcoma in the cerebellum as the primary presentation in a patient with APL and abnormal coagulation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Cerebral Hemorrhage / etiology. Leukemia, Promyelocytic, Acute / complications. Sarcoma, Myeloid / etiology
  • [MeSH-minor] Adult. Bone Marrow / pathology. Cerebellar Ataxia / etiology. Cerebellum / pathology. Chimera / genetics. Female. Gene Fusion / genetics. Granulocyte Precursor Cells / pathology. Humans. Inclusion Bodies / pathology. Karyotyping. Magnetic Resonance Imaging. Receptors, Retinoic Acid / genetics

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  • (PMID = 17405265.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Retinoic Acid; 0 / retinoic acid receptor alpha
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67. Rodriguez FJ, Eberhart C, O'Neill BP, Slezak J, Burger PC, Goldthwaite P, Wu W, Giannini C: Histopathologic grading of adult medulloblastomas. Cancer; 2007 Jun 15;109(12):2557-65
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  • [Title] Histopathologic grading of adult medulloblastomas.
  • Whether the same applies to adult medulloblastomas is not known.
  • METHODS: The study included 74 adult patients with histologically confirmed medulloblastomas and retrospectively reassessed 67 cases with available slides for the presence of nodularity, collagen deposition (desmoplasia without nodules), and degree and extent of anaplasia.
  • CONCLUSIONS: The incidence of severe anaplasia in adult medulloblastomas is lower than in the pediatric population.
  • However, the significance of severe anaplasia should be regarded with caution based on the small number of tumors with this feature in the current study.
  • [MeSH-major] Cerebellar Neoplasms / classification. Medulloblastoma / classification
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Female. Humans. Immunoenzyme Techniques. Incidence. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Sex Distribution. Survival Rate

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  • [Copyright] Copyright 2007 American Cancer Society.
  • (PMID = 17487854.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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68. Sokolov AA, Gharabaghi A, Tatagiba MS, Pavlova M: Cerebellar engagement in an action observation network. Cereb Cortex; 2010 Feb;20(2):486-91
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  • [Title] Cerebellar engagement in an action observation network.
  • The cerebellum has traditionally been viewed as a brain structure subserving skilled motor behaviors.
  • However, the cerebellum might be involved not only in movement coordination, but also in action observation and understanding of others' actions.
  • Here, by combining visual psychophysics with a lesion analysis, we assessed visual sensitivity to human walking in patients with lesions to the left cerebellum.
  • Patients with left lateral cerebellar lesions exhibit deficits in visual sensitivity to body motion, whereas medial lesions do not substantially affect visual perception of human locomotion.
  • The findings point to left lateral cerebellar involvement in an action observation network.
  • We discuss possible mechanisms of cerebellar engagement in visual social perception revealed by body motion.
  • [MeSH-major] Cerebellar Diseases / psychology. Cerebellum / physiology. Motion Perception / physiology. Movement / physiology. Social Behavior. Visual Perception / physiology
  • [MeSH-minor] Adult. Brain Mapping. Cerebellar Ataxia / pathology. Cerebellar Ataxia / physiopathology. Cerebellar Ataxia / psychology. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / psychology. Disability Evaluation. Female. Functional Laterality / physiology. Humans. Imitative Behavior / physiology. Magnetic Resonance Imaging. Male. Middle Aged. Movement Disorders / etiology. Movement Disorders / pathology. Movement Disorders / physiopathology. Nerve Net / anatomy & histology. Nerve Net / physiology. Neuropsychological Tests. Psychophysics

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  • (PMID = 19546157.001).
  • [ISSN] 1460-2199
  • [Journal-full-title] Cerebral cortex (New York, N.Y. : 1991)
  • [ISO-abbreviation] Cereb. Cortex
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Martin SE, Al-Khatib SM, Turner MS, Douglas-Akinwande AC, Hattab EM: A 41-year-old woman with von Hippel-Lindau and a cerebellar lesion. Brain Pathol; 2010 Mar;20(2):511-4
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  • [Title] A 41-year-old woman with von Hippel-Lindau and a cerebellar lesion.
  • MRI revealed a well-circumscribed, partially cystic cerebellar neoplasm, consistent with hemangioblastoma.
  • The tumor was resected and the diagnosis of hemangioblastoma confirmed.
  • RCC metastatic to a CNS hemangioblastoma is the second most common type of tumor-to-tumor metastasis, which may be due to a number of factors.
  • Proper immunostaining panels are required to clearly identify these cases since both tumor may have similar histology.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / diagnosis. Brain Neoplasms / pathology. Cerebellum / pathology. Diagnosis, Differential. Female. Humans. Kidney Neoplasms / pathology. Magnetic Resonance Imaging

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  • (PMID = 20438472.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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70. Miyazawa T, Aida S, Shima K: Hemorrhagic cerebellar anaplastic glioma appearing 12 years after prophylactic cranial radiotherapy for acute lymphocytic leukemia. Neurol Med Chir (Tokyo); 2008 Mar;48(3):126-30
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  • [Title] Hemorrhagic cerebellar anaplastic glioma appearing 12 years after prophylactic cranial radiotherapy for acute lymphocytic leukemia.
  • A radiation-induced cerebellar glioma is extremely rare, and the etiology of such a tumor is unknown.
  • We report a rare case of hemorrhagic cerebellar anaplastic glioma occurring 12 years after prophylactic cranial radiotherapy for acute lymphocytic leukemia.
  • We discuss the etiologies of the radiation-induced hemorrhagic cerebellar glioma as a secondary malignancy after radiotherapy.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Glioma / etiology. Intracranial Hemorrhages / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
  • [MeSH-minor] Adult. Anaplasia / etiology. Anaplasia / pathology. Humans. Male. Radiotherapy / adverse effects. Time Factors

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  • (PMID = 18362460.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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71. Alvarez-Betancourt L, Ramírez-Mendoza A, López-Ortega SJ, Caldera-Duarte A: [Spontaneous cerebellar haematoma. Diagnosis, management and follow-up in 18 patients]. Gac Med Mex; 2005 May-Jun;141(3):191-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spontaneous cerebellar haematoma. Diagnosis, management and follow-up in 18 patients].
  • OBJECTIVE: Describe eighteen patients with spontaneous cerebellar haematoma (SCH), their diagnosis, management and outcome.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / therapy. Hematoma / diagnosis. Hematoma / therapy. Intracranial Hemorrhages / diagnosis. Intracranial Hemorrhages / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 16025983.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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72. Roth J, Nass D, Ram Z: Cerebellar tumor extension as a late event of long-standing, supratentorial low-grade gliomas: case report. Neurosurgery; 2006 Jun;58(6):E1210; discussion E1210
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  • [Title] Cerebellar tumor extension as a late event of long-standing, supratentorial low-grade gliomas: case report.
  • OBJECTIVE AND IMPORTANCE: Nonpilocytic low-grade glial tumors in adults occur mostly in the supratentorial compartment.
  • The occurrence of LGG in the cerebellum in the setting of a previously existing supratentorial glioma is rare.
  • All three patients presented years after their initial diagnosis with a second, nonenhancing lesion in the cerebellum, compatible with the radiological appearance of LGG.
  • Two patients subsequently became symptomatic from these lesions and underwent surgical resection of the cerebellar lesions that were found to have similar pathological features to the original supratentorial tumors.
  • INTERVENTION: Magnetic resonance imaging did not demonstrate tumor continuity between the supratentorial and infratentorial lesions in any of the patients.
  • The third patient has shown no cerebellar symptoms to date and is only followed with periodic magnetic resonance imaging.
  • CONCLUSION: The anatomic/pathological basis of these rare cases may include a primary, multicentric tumor formation, or a secondary tumor infiltration of the cerebrocerebellar pathways, leading to the formation of the cerebellar tumor.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Glioma / diagnosis. Magnetic Resonance Imaging. Neoplasms, Second Primary / diagnosis. Supratentorial Neoplasms / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged

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  • (PMID = 16723871.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Striano P, Coppola A, Vacca G, Zara F, Brescia Morra V, Orefice G, Striano S: Levetiracetam for cerebellar tremor in multiple sclerosis: an open-label pilot tolerability and efficacy study. J Neurol; 2006 Jun;253(6):762-6
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  • [Title] Levetiracetam for cerebellar tremor in multiple sclerosis: an open-label pilot tolerability and efficacy study.
  • We conducted an open-label trial to evaluate the effect of levetiracetam (LEV) to treat cerebellar tremor in MS patients.
  • PATIENTS AND METHODS: Fourteen MS patients, aged 27 to 57 years, with cerebellar tremor.
  • CONCLUSIONS: LEV could be useful for the management of cerebellar tremor in MS and the good tolerability makes it easy to test.
  • [MeSH-major] Anticonvulsants / therapeutic use. Cerebellar Neoplasms / drug therapy. Piracetam / analogs & derivatives
  • [MeSH-minor] Activities of Daily Living / psychology. Adult. Disability Evaluation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multiple Sclerosis / complications. Multiple Sclerosis / drug therapy. Pilot Projects. Severity of Illness Index. Statistics, Nonparametric

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  • (PMID = 16683063.001).
  • [ISSN] 0340-5354
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anticonvulsants; 230447L0GL / etiracetam; ZH516LNZ10 / Piracetam
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74. Zilidis G, Cadoux-Hudson TA: Recurrent dural based cystic cerebellar haemangioblastoma in a patient with von Hippel-Lindau disease. Acta Neurochir (Wien); 2007;149(4):433-6
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  • [Title] Recurrent dural based cystic cerebellar haemangioblastoma in a patient with von Hippel-Lindau disease.
  • Surgical excision of cerebellar haemangioblastomas, once they become Symptomatic, is the standard treatment in patients with von Hippel-Lindau disease.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Dura Mater / surgery. Hemangioblastoma / surgery. Meningeal Neoplasms / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Cerebellum / pathology. Cerebellum / physiopathology. Cerebellum / surgery. Female. Humans. Infratentorial Neoplasms / complications. Infratentorial Neoplasms / pathology. Infratentorial Neoplasms / surgery. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 17357827.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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75. Lawton MT, Quiñones-Hinojosa A, Jun P: The supratonsillar approach to the inferior cerebellar peduncle: anatomy, surgical technique, and clinical application to cavernous malformations. Neurosurgery; 2006 Oct;59(4 Suppl 2):ONS244-51; discussion ONS251-2
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  • [Title] The supratonsillar approach to the inferior cerebellar peduncle: anatomy, surgical technique, and clinical application to cavernous malformations.
  • OBJECTIVE: To introduce the supratonsillar approach, an approach that traverses the tonsillobiventral fissure in a trajectory over the cerebellar tonsil to the inferior cerebellar peduncle, and to demonstrate the utility of this approach for resecting peduncular cavernous malformations.
  • METHODS: Anatomy of the cerebellar tonsil and surrounding fissures, arteries, and veins are reviewed using cadaveric brain specimens.
  • RESULTS: Of our experience with 171 patients with cavernous malformations, six patients had lesions in the inferior cerebellar peduncle that were resected using the supratonsillar approach.
  • CONCLUSION: The supratonsillar approach differs from the transvermian and telovelar approaches to the fourth ventricle, with a more superolateral trajectory that leads instead to the inferior cerebellar peduncle.
  • By splitting the tonsillobiventral fissure and mobilizing the tonsil inferomedially, the point of access to the lesion is deepened and transgression of normal cerebellar tissue is minimized.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / surgery. Cerebellum / pathology. Cerebellum / surgery. Hemangioma, Cavernous, Central Nervous System / pathology. Hemangioma, Cavernous, Central Nervous System / surgery. Palatine Tonsil / pathology
  • [MeSH-minor] Adult. Female. Humans. In Vitro Techniques. Male. Practice Guidelines as Topic. Practice Patterns, Physicians'

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  • (PMID = 17041494.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Saito T, Hama S, Kajiwara Y, Sugiyama K, Yamasaki F, Arifin MT, Arita K, Kurisu K: Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas. Anticancer Res; 2006 Mar-Apr;26(2B):1351-7
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  • [Title] Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas.
  • BACKGROUND: Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood.
  • PATIENTS AND METHODS: Clinico-immunohistochemical findings were retrospectively analyzed in 43 supratentorial- and 7 cerebellar GBM.
  • The correlation between survival and immunopositivity for p53, epidermal growth factor receptor (EGFR) and Ki-67 in these tumors was statistically analyzed and compared.
  • All 5 cerebellar GBM patients treated with radio- and chemotherapy were EGFR-immunonegative; they survived significantly longer than patients with supratentorial GBM (p=0.0296) possibly because their EGFR negativity rendered their tumors more highly radiosensitive.
  • CONCLUSION: The better prognosis of patients with cerebellar, EGFR-negative tumors compared to patients with supratentorial tumors is due to the higher radiosensitivity of these tumors.
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Glioblastoma / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Supratentorial Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Child. Female. Humans. Immunohistochemistry. Male. Nitrosourea Compounds / administration & dosage. Prognosis. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome

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  • (PMID = 16619544.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Nitrosourea Compounds; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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77. Sherman JH, Sheehan JP, Elias WJ, Jane JA Sr: Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases. Surg Neurol; 2005 May;63(5):476-9
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  • [Title] Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases.
  • BACKGROUND: Mutism has been associated with injury to midline cerebellar structures secondary to degenerative disease, tumors, hemorrhage, or surgery.
  • Typically, cerebellar mutism syndrome (CMS) has been seen in children and only rarely described in adults after surgery of the posterior fossa.
  • CASE DESCRIPTION: The authors report on 2 patients each of whom developed cerebellar mutism after tumor resection using a posterior fossa approach.
  • The first patient underwent gross total resection of a pineal region tumor via a supracerebellar approach.
  • The second patient underwent posterior fossa decompression for a left cerebellar hemispheric renal cell carcinoma metastasis with adjacent hemorrhage.
  • One patient displayed a variant of cerebellar mutism with severe ataxic dysarthria without complete absence of speech, whereas the other demonstrated frank mutism.
  • CONCLUSION: It is paramount that neurosurgeons be aware of cerebellar mutism with regard to its very rare occurrence in adults, its time of onset, and typical self-limiting course.
  • [MeSH-major] Brain Neoplasms / surgery. Carcinoma, Renal Cell / surgery. Cerebellum / surgery. Cranial Fossa, Posterior / surgery. Dermoid Cyst / surgery. Mutism / etiology. Neurosurgical Procedures / adverse effects
  • [MeSH-minor] Adult. Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / secondary. Cerebellar Neoplasms / surgery. Decompression, Surgical / adverse effects. Female. Humans. Kidney Neoplasms / pathology. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual. Pinealoma / pathology. Pinealoma / surgery. Postoperative Complications / etiology. Postoperative Complications / pathology. Radiosurgery. Radiotherapy. Treatment Outcome

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  • [CommentIn] Surg Neurol. 2006 Apr;65(4):424 [16531220.001]
  • (PMID = 15883080.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Padovani L, André N, Carrie C, Muracciole X: [Childhood and adult medulloblastoma: what difference?]. Cancer Radiother; 2009 Oct;13(6-7):530-5
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  • [Title] [Childhood and adult medulloblastoma: what difference?].
  • Medulloblastoma is the most frequent childhood brain tumor (30%) but account only for less than 1% of adult brain tumor.
  • Due to the rarety in adult population, no prospective studies and few data about late effects are available.
  • Adult medulloblastoma is a therapeutic challenge and their therapeutic strategies are similar to pediatric protocols.
  • In order to improve the understanding of adult disease and to homogenize the treatment, National Cancer Institute (INCa) stimulated the creation of web conference to discuss each case prospectively and to propose a protocol of treatment.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adult. Age Factors. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Brain Neoplasms / epidemiology. Child. Cognition Disorders / epidemiology. Cognition Disorders / etiology. Combined Modality Therapy. France / epidemiology. Humans. Incidence. Molecular Biology / methods. Radiotherapy / adverse effects. Radiotherapy / methods. Surgical Procedures, Operative

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  • (PMID = 19713143.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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79. Majchrzak H, Tymowski M, Majchrzak K, Stepień T: Surgical approaches to pathological lesions of the middle cerebellar peduncle and the lateral part of the pons - clinical observation. Neurol Neurochir Pol; 2007 Sep-Oct;41(5):436-44

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  • [Title] Surgical approaches to pathological lesions of the middle cerebellar peduncle and the lateral part of the pons - clinical observation.
  • BACKGROUND AND PURPOSE: Pathological lesions of the middle cerebellar peduncle include tumours, arteriovenous malformations, cavernous angiomas and spontaneous haematomas.
  • Because of the very low incidence of these lesions, surgical approaches to the middle cerebellar peduncle are not commonly known.
  • MATERIAL AND METHODS: Five patients were operated on, four with tumours and one with spontaneous haematoma of the middle cerebellar peduncle.
  • CONCLUSIONS: Pathological lesions of the middle cerebellar peduncle can be effectively treated surgically.
  • The cerebellomedullary fissure approach has been found to be the best because it provides greater access to the dorsal surface of the middle cerebellar peduncle and to the lateral part of the pons.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellum / surgery. Cerebral Hemorrhage / surgery. Craniotomy / methods. Pons / surgery
  • [MeSH-minor] Adult. Cranial Nerve Injuries / etiology. Female. Gait Disorders, Neurologic / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications. Treatment Outcome

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  • (PMID = 18033644.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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80. Kajimoto K, Oku N, Kimura Y, Kato H, Tanaka MR, Kanai Y, Kitagawa K, Maruno M, Yoshimine T, Hori M, Hatazawa J: Crossed cerebellar diaschisis: a positron emission tomography study with L-[methyl-11C]methionine and 2-deoxy-2-[18F]fluoro-D-glucose. Ann Nucl Med; 2007 Feb;21(2):109-13
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  • [Title] Crossed cerebellar diaschisis: a positron emission tomography study with L-[methyl-11C]methionine and 2-deoxy-2-[18F]fluoro-D-glucose.
  • OBJECTIVE: Crossed cerebellar diaschisis (CCD) is defined as a depression of blood flow and oxidative metabolism of glucose in the cerebellum contralateral to a supratentorial brain lesion, as detected with positron emission tomography (PET) and single photon emission computed tomography.
  • METHODS: In 12 patients with a unilateral supratentorial brain tumor, we evaluated the uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) and MET in the cerebellar hemispheres by means of PET.
  • Asymmetry index (AI) was defined as a difference in the average count between the ipsilateral and contralateral cerebellar hemispheres divided by the average count in both cerebellar hemispheres.
  • CONCLUSIONS: Different from glucose metabolism, cerebellar MET uptake was not affected in CCD.
  • The present study may indicate that cerebellar MET uptake is independent of suppression of cerebellar neuronal activity.
  • [MeSH-major] Cerebellar Diseases / metabolism. Cerebellar Diseases / radionuclide imaging. Fluorodeoxyglucose F18 / pharmacokinetics. Methionine / analogs & derivatives. Positron-Emission Tomography / methods
  • [MeSH-minor] Adult. Aged. Brain Neoplasms / metabolism. Brain Neoplasms / radionuclide imaging. Cerebellum / blood supply. Cerebellum / metabolism. Cerebellum / radionuclide imaging. Female. Humans. Male. Middle Aged. Radiopharmaceuticals / pharmacokinetics. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 17424977.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; AE28F7PNPL / Methionine; BN630929UL / methionine methyl ester
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81. Oztürk S, Soyluk O, Görçin S, Alişir S, Güven D, Türkmen A, Sever MS: A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report. J Nephrol; 2005 Nov-Dec;18(6):781-2
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  • [Title] A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report.
  • Hemangioblastoma (HB) is especially prevalent in the cerebellum.
  • On cranial magnetic resonance imaging (MRI), a mass lesion in the right cerebellar hemisphere was observed, 3 x 3 x 3 cm in size, which was pushing against the fourth ventricle, and the right cerebellar peduncle.
  • The pathological diagnosis was cerebellar hemangioblastoma.
  • DISCUSSION: HB causes 2% of all intracranial tumors in the general population.
  • The treatment is surgical excision of the tumor, as in this case.
  • CONCLUSION: When cerebellar symptoms occur or a cerebellar mass lesion is detected in an organ recipient, HB should be considered in the differential diagnosis.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Hemangioblastoma / etiology. Kidney Transplantation / adverse effects
  • [MeSH-minor] Adult. Craniotomy. Follow-Up Studies. Humans. Kidney Failure, Chronic / surgery. Magnetic Resonance Imaging. Male

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  • (PMID = 16358240.001).
  • [ISSN] 1121-8428
  • [Journal-full-title] Journal of nephrology
  • [ISO-abbreviation] J. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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82. Crocker M, deSouza R, Epaliyanage P, Bodi I, Deasy N, Selway R: Masson's tumour in the right parietal lobe after stereotactic radiosurgery for cerebellar AVM: case report and review. Clin Neurol Neurosurg; 2007 Nov;109(9):811-5
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  • [Title] Masson's tumour in the right parietal lobe after stereotactic radiosurgery for cerebellar AVM: case report and review.
  • We present a 50-year-old patient who had undergone stereotactic radiosurgery for a cerebellar vermian arteriovenous malformation.
  • [MeSH-major] Brain Neoplasms / etiology. Cerebellum / blood supply. Hemangioendothelioma / etiology. Intracranial Arteriovenous Malformations / surgery. Parietal Lobe. Radiosurgery / adverse effects
  • [MeSH-minor] Adult. Female. Humans. Middle Aged

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  • (PMID = 17714859.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 23
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83. Dave KA, Bordey A: GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: implications for proliferation. IUBMB Life; 2009 May;61(5):496-503
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  • [Title] GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: implications for proliferation.
  • GABA, glutamate, and their complement of receptors are essential signaling molecules that regulate developmental processes in both embryonic and young adult mammals.
  • In this review, we describe the current knowledge on the role of GABA and glutamate in development, focusing on the perinatal cerebellum.
  • From our review of the literature and these data, we hypothesize that GABA(A) receptors and metabotropic glutamate receptors may be a novel target for the pharmacological regulation of the cerebellar tumors, medulloblastomas.

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  • (PMID = 19391160.001).
  • [ISSN] 1521-6551
  • [Journal-full-title] IUBMB life
  • [ISO-abbreviation] IUBMB Life
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC007681; United States / NINDS NIH HHS / NS / NS048256; United States / NIDCD NIH HHS / DC / DC007681-02; United States / NIDCD NIH HHS / DC / DC007681; United States / NINDS NIH HHS / NS / NS048256-04; United States / NINDS NIH HHS / NS / R01 NS048256; United States / NINDS NIH HHS / NS / R01 NS048256-04; United States / NIDCD NIH HHS / DC / R01 DC007681-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, GABA-A; 3KX376GY7L / Glutamic Acid; 56-12-2 / gamma-Aminobutyric Acid; SY7Q814VUP / Calcium
  • [Number-of-references] 104
  • [Other-IDs] NLM/ NIHMS100672; NLM/ PMC2675662
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84. Taraszewska A, Czernicki Z, Andrychowski J: Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults. Folia Neuropathol; 2005;43(3):172-7
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  • [Title] Hemosiderin pigmentation of tumour cells in cerebellar pilocytic astrocytoma associated with post-traumatic hemorrhage in adults.
  • We report an unusual case of pigmented cerebellar pilocytic astrocytoma presenting with posttraumatic hemorrhage in a 38-year-old man with no history related to the tumor.
  • CT and MRI examination after head injury demonstrated unexpectedly the cystic lesion of 2 cm in diameter in the region of the right cerebellar hemisphere and vermis.
  • In the literature, the examples of neuroepithelial tumors with hemosiderin pigmentation of tumor cells have been rarely documented.

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  • (PMID = 16245213.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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85. Kim SJ, Lee WY, Kim BJ, Kim JY, Hong SB, Tae WS, Seo DW: Isolated tongue tremor after removal of cerebellar pilocytic astrocytoma: Functional analysis with SPECT study. Mov Disord; 2007 Sep 15;22(12):1825-8
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  • [Title] Isolated tongue tremor after removal of cerebellar pilocytic astrocytoma: Functional analysis with SPECT study.
  • We experienced a case of isolated tongue tremor after the removal of a cerebellar pilocytic astrocytoma.
  • [MeSH-minor] Adult. Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Female. Humans. Magnetic Resonance Imaging. Olivary Nucleus / pathology. Olivary Nucleus / radionuclide imaging. Red Nucleus / pathology. Red Nucleus / radionuclide imaging

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  • [Copyright] (c) 2007 Movement Disorder Society.
  • (PMID = 17657811.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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86. Rubello D, Vitaliani R, Rigoni MT, Rampin L, Giometto B, Casara D, Zonzin GC, Zavagno G, Capirci C, Shapiro B, Muzzio PC: A rare case of paraneoplastic cerebellar degeneration discovered by whole-body F-18 FDG PET. Clin Nucl Med; 2005 Oct;30(10):704-6
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  • [Title] A rare case of paraneoplastic cerebellar degeneration discovered by whole-body F-18 FDG PET.
  • A rare case of paraneoplastic cerebellar degeneration (PCD) in a 36-year-old woman is reported.
  • No tumor was found until April 2003; repeated CT scan, ultrasound, and mammographic examinations were negative.
  • In the reported case, F-18 FDG PET played a crucial role in detecting the unknown primary tumor in a young patient with PCD.
  • [MeSH-major] Breast Neoplasms / complications. Breast Neoplasms / diagnosis. Fluorodeoxyglucose F18. Paraneoplastic Cerebellar Degeneration / diagnosis. Paraneoplastic Cerebellar Degeneration / etiology. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods. Whole Body Imaging / methods
  • [MeSH-minor] Adult. Female. Humans. Radiopharmaceuticals. Rare Diseases / diagnosis


87. Selek U, Zorlu F, Hurmuz P, Cengiz M, Turker A, Soylemezoglu F, Gurkaynak M: Craniospinal radiotherapy in adult medulloblastoma. Strahlenther Onkol; 2007 May;183(5):236-40
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  • [Title] Craniospinal radiotherapy in adult medulloblastoma.
  • PURPOSE: To evaluate the outcome and prognostic factors of adult patients with medulloblastoma.
  • PATIENTS AND METHODS: 26 adult medulloblastoma patients with a median age of 27 were subjected to craniospinal radiotherapy.
  • Patient characteristics, treatment factors and tumor characteristics failed to show any significance in univariate analysis.
  • CONCLUSION: Yet, the current standard of care seems to remain craniospinal irradiation after maximal surgical resection of the primary neoplasm without clear indications for adjuvant chemotherapy.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Cranial Irradiation. Medulloblastoma / radiotherapy. Spine / radiation effects
  • [MeSH-minor] Adolescent. Adult. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17497094.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Yong RL, Kavanagh EC, Fenton D, Dorovini-Zis K, Heran MK, Haw CS: Midline cerebellar medulloblastoma in a seventy-one-year-old patient. Can J Neurol Sci; 2006 Feb;33(1):101-4
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  • [Title] Midline cerebellar medulloblastoma in a seventy-one-year-old patient.
  • Hemispheric, rather than midline, cerebellar medulloblastomas are more common in older children and adults.
  • RESULTS: Histological examination showed a densely cellular neoplasm composed of small cells with a tendency towards neuroblastic rosette formation.
  • CONCLUSION: Adult medulloblastoma should be considered in the differential diagnosis of a partially calcified hyperattenuating mass within the fourth ventricle.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebral Ventricle Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Aged. Brain Neoplasms / pathology. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Fourth Ventricle / pathology. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Phosphopyruvate Hydratase / metabolism. Synaptophysin / metabolism. Tomography, X-Ray Computed

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  • (PMID = 16583731.001).
  • [ISSN] 0317-1671
  • [Journal-full-title] The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • [ISO-abbreviation] Can J Neurol Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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89. Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T: Genetic characterization of adult infratentorial gliomas. J Neurooncol; 2009 Feb;91(3):251-5
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  • [Title] Genetic characterization of adult infratentorial gliomas.
  • Adult infratentorial gliomas are rare and have not been well studied.
  • We therefore conducted genetic analysis of those tumors to see if there was any characteristic that could be relevant in clinical management and understanding of tumorigenesis.
  • Nineteen adult infratentorial gliomas were analyzed for chromosomal aberration by comparative genomic hybridization, and for expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry.
  • The most frequent chromosomal aberration was the gain of 7p, and five of the seven cerebellar or fourth ventricle malignant gliomas had that aberration.
  • However, the gain of 7q, the characteristic abnormality of supratentorial astrocytomas commonly associated with the gaining of 7p, was observed only in 1 of 11 adult infratentorial astrocytic tumors.
  • Our findings might suggest the presence of distinct tumorigenic pathway in adult infratentorial gliomas.
  • [MeSH-major] Brain Neoplasms / genetics. Frontal Lobe / pathology. Glioma / genetics. Receptor, Epidermal Growth Factor / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Chromosome Aberrations. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. Chromosomes, Human, Pair 7 / genetics. Comparative Genomic Hybridization. Female. Humans. Loss of Heterozygosity. Male. Middle Aged. Young Adult

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  • (PMID = 18941867.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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90. Ardavanis A, Sykoutri D, Kountourakis P, Doufexis D, Korkolis D, Tzerbini H, Skarlatos I, Mosa E, Rigatos G: Paraneoplastic cerebellar degeneration in a patient with pseudomyxoma peritonei and breast cancer: case report and literature review. In Vivo; 2009 Sep-Oct;23(5):835-8
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  • [Title] Paraneoplastic cerebellar degeneration in a patient with pseudomyxoma peritonei and breast cancer: case report and literature review.
  • The case of a 31-year-old woman with progressive cerebellar degeneration preceding by several months the diagnosis and treatment of breast cancer initially and pseudomyxoma peritonei (PMP) with evidence of causative association with the latter is presented.
  • Interestingly, neurological symptoms partially regressed transiently only after surgical debulking of the PMP and not after the remission of breast cancer after various chemotherapeutic regimens suggesting an etiological relationship of the former and the cerebellar degeneration.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / secondary. Paraneoplastic Cerebellar Degeneration / pathology. Pseudomyxoma Peritonei / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans


91. Pereira S, Serra D, Freitas PM, Santiago B, Brito O: Epidermal nevus syndrome: an unusual cerebellar involvement. J Neuroradiol; 2009 Oct;36(4):237-9
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  • [Title] Epidermal nevus syndrome: an unusual cerebellar involvement.
  • [MeSH-major] Cerebellar Diseases / complications. Nevus, Pigmented / complications. Skin Neoplasms / complications
  • [MeSH-minor] Arrhythmias, Cardiac / complications. Facial Asymmetry / complications. Female. Hearing Loss / complications. Humans. Magnetic Resonance Imaging. Syndrome. Young Adult


92. Ertas G, Altundag MB, Ucer AR, Cankal F, Altundag K: Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature. J Neurooncol; 2005 Jul;73(3):273-5
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  • [Title] Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature.
  • Common manifestations of the disease are retinal, cerebellar and medullary hemangioblastomas; renal cysts and carcinomas; pancreatic cysts; pheochromocytoma; and papilllary cystadenoma of the epididym.
  • We report the case of a 40-year-old man with type I von Hippel-Lindau disease treated with external radiotherapy for recurrent cerebellar hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Hemangioblastoma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / etiology. Carcinoma, Renal Cell / surgery. Humans. Kidney Neoplasms / etiology. Kidney Neoplasms / surgery. Magnetic Resonance Imaging. Male

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  • (PMID = 15980980.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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93. Tailor JK, Kim AH, Folkerth RD, Black PM: The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report. Neurosurgery; 2008 Sep;63(3):E609-10; discussion E610
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  • [Title] The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report.
  • OBJECTIVE: Dysembryoplastic neuroepithelial tumor (DNT) occurs rarely in the cerebellum.
  • We describe a rare case of cerebellar DNT that developed contrast enhancement after long-term observation and discuss the underlying mechanism and clinical relevance of this unusual phenomenon.
  • CLINICAL PRESENTATION: A 34-year-old woman with known cystic cerebellar lesions presented with increased frequency of vertigo and new onset of truncal ataxia.
  • Magnetic resonance imaging revealed new contrast enhancement in the dominant cystic lesion of the cerebellar vermis without any change in size and shape or evidence of edema.
  • CONCLUSION: This is the first report of the development of contrast enhancement in a previously nonenhancing case of cerebellar DNT.
  • [MeSH-major] Cerebellar Neoplasms / radiography. Contrast Media. Neoplasms, Neuroepithelial / radiography. Teratoma / radiography
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Magnetic Resonance Imaging / trends

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  • (PMID = 18812941.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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94. Kamide T, Nakada M, Hayashi Y, Suzuki T, Hayashi Y, Uchiyama N, Kijima T, Hamada J: Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report. J Neurooncol; 2010 Nov;100(2):299-303
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  • [Title] Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report.
  • Here, we report the case of a patient with cerebellar high-grade glioma that developed after the patient underwent treatment for medulloblastoma.
  • Magnetic resonance image showed a cerebellar tumor with multiple cavernomas and two lesions that were suspected to be meningiomas.
  • The cerebellar tumor was surgically removed.
  • According to pathological examination, the tumor was a high-grade glioma that was positive for methylated O-6-methylguanine-DNA methyltransferase promoter.
  • In the past, he had received radiotherapy at the age of 5, after which he was operated for desmoplastic medulloblastoma in his right cerebellar hemisphere.
  • To our knowledge, this is the first case of radiation-induced double intracranial tumors accompanied by symptomatic cavernoma.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Glioma / etiology. Hemangioma, Cavernous, Central Nervous System / etiology. Meningioma / etiology. Meningioma / pathology. Neoplasms, Radiation-Induced / pathology
  • [MeSH-minor] Adult. DNA Methylation. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Humans. Male. Medulloblastoma / radiotherapy. Meningeal Neoplasms / etiology. Meningeal Neoplasms / genetics. Meningeal Neoplasms / pathology. Polymerase Chain Reaction. Promoter Regions, Genetic / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20354758.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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95. Gontkovsky ST, Nevels R, McDonald NB, Winkelmann MH: Decreased serum glucose levels after initiation of methylphenidate in a patient status post-cerebellar tumour resection: a potential interaction with glipizide. Clin Drug Investig; 2007;27(10):719-25
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  • [Title] Decreased serum glucose levels after initiation of methylphenidate in a patient status post-cerebellar tumour resection: a potential interaction with glipizide.
  • This case report illustrates a significant post-intervention decrease in blood glucose levels subsequent to initiation of methylphenidate to address neurocognitive deficits, status post-acute cerebellar tumour resection, in a 38-year-old female with type 2 diabetes mellitus.
  • [MeSH-minor] Adult. Cerebellar Neoplasms / surgery. Cognition Disorders / drug therapy. Diabetes Mellitus, Type 2 / drug therapy. Drug Interactions. Drug Labeling. Female. Humans. Risk Management. United States. United States Food and Drug Administration

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  • (PMID = 17803347.001).
  • [ISSN] 1173-2563
  • [Journal-full-title] Clinical drug investigation
  • [ISO-abbreviation] Clin Drug Investig
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Central Nervous System Stimulants; 0 / Sulfonylurea Compounds; 207ZZ9QZ49 / Methylphenidate; X7WDT95N5C / Glipizide
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96. Weber DC, Miller RC, Villà S, Hanssens P, Baumert BG, Castadot P, Varlet P, Abacioglu U, Igdem S, Szutowicz E, Nishioka H, Hofer S, Rutz HP, Ozsahin M, Taghian A, Mirimanoff RO: Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network. Int J Radiat Oncol Biol Phys; 2006 Sep 1;66(1):179-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network.
  • PURPOSE: The aim of this study was to assess the outcome in patients with cerebellar glioblastoma (GBM) treated in 15 institutions of the Rare Cancer Network.
  • METHODS AND MATERIALS: Data from a series of 45 adult patients with cerebellar GBM were collected in a retrospective multicenter study.
  • RESULTS: The 1-year and 2-year actuarial overall survival rate was 37.8% and 14.7%, respectively, and was significantly influenced by salvage treatment (p = 0.048), tumor volume (p = 0.044), extent of neurosurgical resection (p = 0.019), brainstem invasion (p = 0.0013), additional treatment after surgery (p < 0.001), and completion of the initial treatment (p < 0.001) on univariate analysis.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Glioblastoma / radiotherapy. Rare Diseases / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy / methods. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 16814953.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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97. Corns R, Crocker M, Kumar A, Salisbury J, Tolias C, Sadler G, Hill M: Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report. Acta Neurochir (Wien); 2010 Jun;152(6):1075-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report.
  • We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Cranial Irradiation. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / radiotherapy. Methotrexate / therapeutic use
  • [MeSH-minor] Adult. Antineoplastic Agents, Hormonal / therapeutic use. Biomarkers, Tumor / analysis. Biopsy. Cerebellum / pathology. Combined Modality Therapy. Dexamethasone / therapeutic use. Dose-Response Relationship, Drug. Female. Humans. Infusions, Intravenous. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Neurologic Examination. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 19936608.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 7S5I7G3JQL / Dexamethasone; YL5FZ2Y5U1 / Methotrexate
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98. Ongürü O, Karslioglu Y, Ozcan A, Celik E: Anti-apoptotic and growth-promoting markers in adult medulloblastomas. Clin Neuropathol; 2010 Nov-Dec;29(6):384-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anti-apoptotic and growth-promoting markers in adult medulloblastomas.
  • AIM: the aim of this study was to investigate the pathologic features, proliferation potential and expression of some anti-apoptotic and growth-promoting markers in adult medulloblastomas.
  • METHOD: we analyzed the immunohistochemical expression of survivin, c-KIT, Bcl-2, fascin, p-53 and Ki-67 in 18 adult medulloblastomas (> 16 years of age).
  • CONCLUSION: frequent nuclear survivin expression implies the predominance of anti-apoptotic factors in pathogenesis of adult medulloblastomas.
  • It may also be a potential therapeutic target for adult medulloblastomas.
  • Although Blc-2 immunoreactivity was previously reported in approximately 30% in medulloblastomas, we have observed that it is rarely expressed in the present series of adult medulloblastomas.
  • Mild-to-moderate cytoplasmic c-KIT immunoreactivity without membranous staining in adult medulloblastomas may support the previous studies reporting low level of c-KIT protein expression with lack of activating mutations in medulloblastomas.
  • It seems p53 is rarely involved in the course of develepment of adult medulloblastomas.
  • [MeSH-major] Apoptosis Regulatory Proteins / metabolism. Cerebellar Neoplasms / metabolism. Growth Substances / metabolism. Medulloblastoma / metabolism
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Carrier Proteins / metabolism. Female. Humans. Inhibitor of Apoptosis Proteins. Male. Microfilament Proteins / metabolism. Microtubule-Associated Proteins / metabolism. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / metabolism. Proto-Oncogene Proteins c-kit / metabolism. Retrospective Studies. Tumor Suppressor Protein p53 / metabolism. Young Adult

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  • (PMID = 21073843.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Growth Substances; 0 / Inhibitor of Apoptosis Proteins; 0 / Microfilament Proteins; 0 / Microtubule-Associated Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 146808-54-0 / fascin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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99. Rushing EJ, Smith AB, Smirniotopoulos JG, Douglas AF, Zeng W, Azumi N: Occult leptomeningeal large cell medulloblastoma in an adult. Clin Neuropathol; 2009 May-Jun;28(3):188-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occult leptomeningeal large cell medulloblastoma in an adult.
  • We report the first case of this entity in an adult that proved to be an unsuspected primary leptomeningeal tumor.
  • Postmortem examination of the brain was notable for necrotic cerebellar tonsils, but demonstrated no evidence of an intraparenchymal mass lesion.
  • Microscopic examination of the cerebellum revealed discohesive neoplastic cells, which showed characteristic dot-like immunoreactivity for synaptophysin, diagnostic of large cell medulloblastoma within the subarachnoid space.
  • CONCLUSIONS: Our experience with this unique case illustrates the challenges of diagnosing a primary leptomeningeal neoplasm.
  • This case also underscores the importance of maintaining a high degree of suspicion for leptomeningeal neoplasms in patients who present with imaging studies suspicious for Chiari I malformation.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology. Meningeal Neoplasms / pathology
  • [MeSH-minor] Adult. Arnold-Chiari Malformation / complications. Fatal Outcome. Humans. Intervertebral Disc Displacement / complications. Magnetic Resonance Imaging. Male

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  • (PMID = 19537136.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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100. Romoli S, Abbruzzese A, Castagna M, Becherini F, Parenti G: Unusual exophytic subependymoma in the bulbo-cerebellar angle. Case report. J Neurosurg Sci; 2007 Jun;51(2):81-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual exophytic subependymoma in the bulbo-cerebellar angle. Case report.
  • [MeSH-major] Cerebellopontine Angle / pathology. Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Glioma, Subependymal / pathology
  • [MeSH-minor] Adult. Cranial Nerves / pathology. Cranial Nerves / surgery. Humans. Hydrocephalus / etiology. Hydrocephalus / physiopathology. Hydrocephalus / prevention & control. Magnetic Resonance Imaging. Male. Medulla Oblongata / pathology. Medulla Oblongata / surgery. Muscle Weakness / etiology. Nausea / etiology. Neurosurgical Procedures. Pons / pathology. Pons / surgery. Treatment Outcome

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  • (PMID = 17571040.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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