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1. Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M: Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol; 2006 Jun-Jul;27(6):1362-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apparent diffusion coefficients for differentiation of cerebellar tumors in children.
  • We hypothesized that cerebellar tumors in children can be differentiated by their ADC values.
  • METHODS: Brain MR imaging studies that included ADC maps were retrospectively reviewed in 32 patients with histologically proved cerebellar neoplasm.
  • There were 17 juvenile pilocytic astrocytomas (JPA), 8 medulloblastomas, 5 ependymomas, and 2 rhabdoid (atypical teratoid/rhabdoid tumor [AT/RT]) tumors.
  • Absolute ADC values of contrast-enhancing solid tumor regions and ADC ratios (ADC of solid tumor to ADC of normal-appearing white matter) were compared with the histologic diagnosis.
  • ADC ratios were also significantly different among these 3 tumor types.
  • CONCLUSION: Assessment of ADC values of enhancing solid tumor is a simple and reliable technique for preoperative differentiation of cerebellar tumors in pediatric patients.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / diagnosis. Astrocytoma / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / diagnosis. Ependymoma / pathology. Female. Humans. Infant. Male. Medulloblastoma / diagnosis. Medulloblastoma / pathology

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  • [CommentIn] Nat Clin Pract Neurol. 2007 Feb;3(2):78-9 [17279080.001]
  • (PMID = 16775298.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Ypma PF, Wijermans PW, Koppen H, Sillevis Smitt PA: Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma. Neth J Med; 2006 Jul-Aug;64(7):243-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma.
  • Paraneoplastic cerebellar degeneration (PCD) can present as a severe and (sub)acute cerebellar syndrome.
  • PCD can accompany different kinds of neoplasms including small cell lung cancer, adenocarcinoma of the breast and ovary, and Hodgkin's lymphoma.
  • Despite extensive laboratory and radiological evaluations in this patient with rapidly deteriorating cerebellar syndrome, the diagnosis of a paraneoplastic syndrome was only made after several months, when an anti-Tr antibody was detected in his serum.
  • After starting therapy the cerebellar degeneration stabilised.
  • Improvement of the cerebellar syndrome in anti-Tr autoantibody paraneoplastic disease is a rare achievement.
  • [MeSH-major] Cerebellum / pathology. Hodgkin Disease / diagnosis. Paraneoplastic Cerebellar Degeneration / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Dexamethasone / administration & dosage. Etoposide / administration & dosage. Humans. Male. Neoplasm Staging. Positron-Emission Tomography. Radiotherapy, Adjuvant. Remission Induction. Tomography, X-Ray Computed. Vinblastine / administration & dosage


3. Hayashi S, Takeda N, Komura E: Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report. Neurol Med Chir (Tokyo); 2010;50(12):1105-7
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  • [Title] Symptomatic cerebellar hemorrhage from recurrent hemangioblastoma during delivery. Case report.
  • A 30-year-old woman suffered cerebellar hemorrhage during the delivery of her first child.
  • She had undergone surgical removal of a symptomatic cerebellar hemangioblastoma 6 years previously.
  • Hemangioblastomas are benign tumors that are curable with surgical removal, but can grow during pregnancy.
  • [MeSH-major] Cerebellar Neoplasms / complications. Cerebellum / blood supply. Hemangioblastoma / complications. Intracranial Hemorrhages / etiology. Neoplasm Recurrence, Local / complications
  • [MeSH-minor] Adult. Cerebral Angiography. Female. Humans. Obstetric Labor Complications / etiology. Pregnancy. Pregnancy Complications, Neoplastic / pathology. Pregnancy Complications, Neoplastic / surgery. Treatment Outcome

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  • (PMID = 21206188.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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4. Slattery C, Agius M, Zaman R: Bipolar disorder associated with paraneoplastic cerebellar degeneration: a case report. Psychiatr Danub; 2010 Nov;22 Suppl 1:S137-8
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  • [Title] Bipolar disorder associated with paraneoplastic cerebellar degeneration: a case report.
  • We Present a case report of a patient who suffers from Paraneoplastic cerebellar degeneration (PCD) secondary to which the patient, a young woman, developed Bipolar Affective Disorder.
  • [MeSH-major] Bipolar Disorder / diagnosis. Paraneoplastic Cerebellar Degeneration / diagnosis
  • [MeSH-minor] Antidepressive Agents, Tricyclic. Antimanic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Comorbidity. Drug Therapy, Combination. Female. Hodgkin Disease / diagnosis. Hodgkin Disease / drug therapy. Hodgkin Disease / pathology. Humans. Imipramine / therapeutic use. Intelligence / drug effects. Lithium Carbonate / therapeutic use. Neoplasm Staging. Neuropsychological Tests. Young Adult


5. Tanioka D, Abe T, Ikeda H, Kushima M: [A case of cerebellar tuberculoma]. No Shinkei Geka; 2005 Sep;33(9):919-23
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  • [Title] [A case of cerebellar tuberculoma].
  • We report a case of cerebellar tuberculoma presenting with headache, without any specific data.
  • MRI demonstrated a mass lesion at the right cerebellum, suggesting the presence of a tuberculoma.
  • He underwent total removal of the tumor via the supracerebellar route.
  • The intracranial tuberculoma may be confused with an intracranial neoplasm.
  • In this report, we describe a cerebellar tuberculoma without any abnormal data, suggesting that intracranial tuberculoma should be considered in the differential diagnosis of any intracranial mass lesion.
  • [MeSH-major] Cerebellar Diseases / diagnosis. Tuberculoma / diagnosis
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 16164189.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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6. Grahovac G, Tomac D, Lambasa S, Zoric A, Habek M: Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir (Wien); 2009 Jun;151(6):653-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar glioblastomas: pathophysiology, clinical presentation and management.
  • Glioblastoma multiforme usually affects the cerebral hemispheres with the peak age of onset in the sixth or seventh decade, while cerebellar glioblastoma multiforme is a rare tumour especially in younger patients.
  • We report a 28 year old patient with primary multi-focal cerebellar glioblastoma multiforme and review the pathophysiology, clinical presentation, diagnosis and treatment of cerebellar glioblastomas.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Genetic Predisposition to Disease / genetics. Glioblastoma / pathology. Mutation / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cerebellum / pathology. Cerebellum / radiography. Cerebellum / surgery. Fatal Outcome. Female. Fourth Ventricle / pathology. Fourth Ventricle / surgery. Headache / etiology. Humans. Hydrocephalus / etiology. Intracranial Hypertension / etiology. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Reoperation. Tomography, X-Ray Computed. Vomiting / etiology

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  • (PMID = 19319469.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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7. Bishop FS, Liu JK, Chin SS, Fults DW: Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report. Neurosurgery; 2008 Jun;62(6):E1378-9; discussion E1379
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  • [Title] Recurrent cerebellar hemangioblastoma with enhancing tumor in the cyst wall: case report.
  • OBJECTIVE: Hemangioblastomas are the most common primary intra-axial tumors of the adult posterior fossa and the tumors most often associated with von Hippel-Lindau disease.
  • Resection of cerebellar hemangioblastomas involves tumor excision and drainage of associated cysts.
  • The cyst wall is considered devoid of tumor cells and is not excised.
  • We present an unusual variant of a hemangioblastoma that showed pathological evidence of a tumor within the cyst wall that correlated with radiographic cyst wall enhancement in a patient with a recurrent hemangioblastoma.
  • CLINICAL PRESENTATION: A 38-year-old woman with von Hippel-Lindau disease presented with a recurrent cerebellar hemangioblastoma despite two previous operations during which the mural nodule was removed but the cyst wall was not.
  • Histopathological examination showed a capillary hemangioblastoma with tumor tissue inside the cyst wall.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. Neoplasm Recurrence, Local / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 18824960.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Rodriguez FJ, Eberhart C, O'Neill BP, Slezak J, Burger PC, Goldthwaite P, Wu W, Giannini C: Histopathologic grading of adult medulloblastomas. Cancer; 2007 Jun 15;109(12):2557-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathologic grading of adult medulloblastomas.
  • Whether the same applies to adult medulloblastomas is not known.
  • METHODS: The study included 74 adult patients with histologically confirmed medulloblastomas and retrospectively reassessed 67 cases with available slides for the presence of nodularity, collagen deposition (desmoplasia without nodules), and degree and extent of anaplasia.
  • CONCLUSIONS: The incidence of severe anaplasia in adult medulloblastomas is lower than in the pediatric population.
  • However, the significance of severe anaplasia should be regarded with caution based on the small number of tumors with this feature in the current study.
  • [MeSH-major] Cerebellar Neoplasms / classification. Medulloblastoma / classification
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Female. Humans. Immunoenzyme Techniques. Incidence. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Sex Distribution. Survival Rate

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  • [Copyright] Copyright 2007 American Cancer Society.
  • (PMID = 17487854.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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9. Paslawski T, Duffy JR, Vernino S: Speech and language findings associated with paraneoplastic cerebellar degeneration. Am J Speech Lang Pathol; 2005 Aug;14(3):200-7
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  • [Title] Speech and language findings associated with paraneoplastic cerebellar degeneration.
  • Paraneoplastic cerebellar degeneration (PCD) is an autoimmune disease that can be associated with cancer of the breast, lung, and ovary.
  • While ataxic dysarthria was the most common speech diagnosis, a spastic component was recognized frequently enough to suggest that the subacute (days to weeks) emergence and progression of an ataxic or mixed ataxic-spastic dysarthria in the setting of a more diffuse cerebellar ataxia should raise suspicions about PCD and justify further investigation of a possible immune-related etiology.

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  • (PMID = 16229671.001).
  • [ISSN] 1058-0360
  • [Journal-full-title] American journal of speech-language pathology
  • [ISO-abbreviation] Am J Speech Lang Pathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / PCA-1 antigen, human
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10. Maryniak A, Roszkowski M: [Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors]. Neurol Neurochir Pol; 2005 May-Jun;39(3):202-6
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  • [Title] [Cognitive and affective disturbances in children after surgical treatment of cerebellar tumors].
  • BACKGROUND AND PURPOSE: The cerebellum has been associated with motor control, but more recent studies have extended its contribution to other functions, such as modulation of emotions, behavioral organization or language.
  • The cerebellar cognitive affective syndrome was described primarily in adults.
  • In children, cerebellar lesions are relatively frequent and some are due to neoplasm.
  • MATERIAL AND METHODS: Cognitive and emotional functions were studied in 66 children who underwent surgery for cerebellar pilocytic astrocytoma at the Department of Neurosurgery of the Children Memorial Health Institute.
  • No significant differences between groups of children with different localization of tumor (vermis or cerebellar hemisphere) were observed.
  • CONCLUSIONS: The present study confirms the psychological deficits following cerebellar lesion in children, similar to the cerebellar cognitive affective syndrome reported in adult patients.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Cognition Disorders / etiology. Mood Disorders / etiology. Neurosurgical Procedures / adverse effects. Speech Disorders / etiology
  • [MeSH-minor] Adaptation, Psychological. Adolescent. Adult. Cerebellum / physiopathology. Cerebellum / surgery. Child. Child, Preschool. Female. Humans. Male. Memory Disorders / etiology. Neuropsychological Tests. Parent-Child Relations. Poland. Retrospective Studies

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  • (PMID = 15981157.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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11. Chamberlain MC: Risk of neoplastic meningitis following surgical resection of cerebellar metastases. J Neurooncol; 2008 Aug;89(1):105-7
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  • [Title] Risk of neoplastic meningitis following surgical resection of cerebellar metastases.
  • BACKGROUND: Based on limited literature, an at risk group of patients for development of neoplastic meningitis (NM) are those with resected cerebellar parenchymal metastases.
  • OBJECTIVE: Characterize the incidence of NM in patients with cerebellar metastases treated with either surgical resection or radiotherapy.
  • PATIENTS AND METHODS: A retrospective study to determine outcome and in particular the occurrence of NM in 30 patients with resected cerebellar metastases (Group 1) and in 50 patients with cerebellar metastases treated with radiotherapy only (Group 2).
  • Additionally, 10 patients with coincident cerebellar metastases and NM were identified (Group 3) and compared with these groups.
  • CONCLUSIONS: The incidence of NM following resection of cerebellar metastases (3%: Group 1) was no greater than that seen following treatment of cerebellar metastases with radiotherapy only (2%; Group 2).
  • In addition, in a large data base of patients with NM (40% with parenchymal metastases), cerebellar metastases occurred at a proportion (10%; Group 3) expected based on proportional brain volume and cerebral blood flow.
  • [MeSH-major] Cerebellar Neoplasms / epidemiology. Cerebellum / pathology. Cerebellum / surgery. Meningitis, Aseptic / epidemiology
  • [MeSH-minor] Adult. Aged. Comorbidity. Humans. Incidence. Meninges / pathology. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Neurosurgical Procedures / adverse effects. Retrospective Studies. Risk Factors. Survival Rate

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  • (PMID = 18438610.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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12. Akar S, Drappatz J, Hsu L, Blinder RA, Black PM, Kesari S: Hypertrophic olivary degeneration after resection of a cerebellar tumor. J Neurooncol; 2008 May;87(3):341-5
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  • [Title] Hypertrophic olivary degeneration after resection of a cerebellar tumor.
  • We report a case of hypertrophic olivary degeneration due to cerebellar surgery for a low-grade tumor.
  • A 27-year-old female presented with right-sided paresthesias and intermittent leg paresis following a right cerebellar resection of a tumor 2 weeks prior.
  • Hypertrophic olivary degeneration may be mistaken for tumor progression, post-operative vasculopathy or granulation tissue and should be considered in patients undergoing cerebellar surgery.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Neurosurgical Procedures / adverse effects. Olivary Nucleus / pathology
  • [MeSH-minor] Adult. Ataxia / etiology. Diagnosis, Differential. Female. Humans. Hypertrophy. Hypesthesia / etiology. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology

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  • (PMID = 18217209.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Mano Y, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T: [A case report of cerebellar pleomorphic xanthoastrocytoma]. No Shinkei Geka; 2009 Jun;37(6):586-90
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  • [Title] [A case report of cerebellar pleomorphic xanthoastrocytoma].
  • Pleomorphic xanthoastrocytoma (PXA) is a type of astrocytic neoplasm, classified as WHO grade II, which mainly occurs supratentorially, and rarely infratentorially.
  • We report an unusual case of PXA in the cerebellar vermis.
  • Magnetic resonance imaging and computed tomography demonstrated a mass lesion with cyst in the cerebellar vermis.
  • The histological diagnosis was PXA of the cerebellar vermis.
  • This case suggests that PXA should be considered in the differential diagnosis of cystic lesion in the cerebellar vermis.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19522287.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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14. Patrick TA, Giannini C, Ebersold MJ, Link MJ: Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report. J Neurosurg; 2006 Mar;104(3):452-6
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  • [Title] Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report.
  • Metastatic seeding or iatrogenic implantation of numerous types of primary central nervous system tumors, typically along cerebrospinal fluid pathways, is a frequently described albeit rare phenomenon and has never been reported in association with vestibular schwannoma (VS).
  • The authors present a case of inadvertent surgical implantation of VS into the cerebellar hemisphere during resection of a recurrent VS in the cerebellopontine angle and internal auditory canal.
  • Five years later--10 years after initial presentation--follow-up imaging revealed a 1-cm recurrence of the VS and a separate 2.2-cm tumor in the inferior cerebellar parenchyma with surrounding edema.
  • Both tumors were removed without complication by reopening the previous retrosigmoid craniotomy.
  • Histological evaluation of these tumors revealed features typical of VS and similar to those of the tissue obtained from the two prior resections.
  • Given the similarities among these tumors in pathological appearance and mitotic index, the presence of the intraparenchymal cerebellar schwannoma was probably due to intraoperative iatrogenic implantation.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Neuroma, Acoustic / etiology
  • [MeSH-minor] Adult. Cerebellopontine Angle / pathology. Humans. Iatrogenic Disease. Male. Mitotic Index. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16572663.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Sakaura H, Hosono N, Mukai Y, Ishii T, Yoshikawa H: Multiple cerebellar hemorrhagic infarctions following surgery for a huge atlantoaxial neurinoma. Spine J; 2006 Jan-Feb;6(1):86-9
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  • [Title] Multiple cerebellar hemorrhagic infarctions following surgery for a huge atlantoaxial neurinoma.
  • BACKGROUND CONTEXT: There have been only five reported cases with cerebellar hemorrhagic infarction after spinal surgery, and the underlying pathomechanism remains obscure.
  • PURPOSE: To describe a case with multiple cerebellar hemorrhagic infarctions after surgery for a huge atlantoaxial neurinoma.
  • After surgery, the patient was lethargic with slurred speech and subsequently developed cerebellar symptoms, although preoperative myelopathic symptoms did not worsen.
  • RESULTS: Magnetic resonance imaging of the brain after surgery showed multiple cerebellar hemorrhagic infarctions.
  • In response to the conservative treatment, the patient exhibited neurological recovery with disappearance of cerebellar symptoms.
  • CONCLUSIONS: In the present case with multiple cerebellar hemorrhagic infarctions, venous infarction appears more likely to be the cause of cerebellar hemorrhagic infarction than arterial infarction.
  • The most likely underlying pathomechanism is a cerebellar venous disturbance precipitated by loss of a large amount of cerebrospinal fluid, although the exact etiology remains elusive.
  • [MeSH-major] Brain Infarction / etiology. Cerebellar Diseases / etiology. Laminectomy / adverse effects. Neurilemmoma / surgery. Postoperative Complications / diagnosis. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Atlanto-Axial Joint. Follow-Up Studies. Humans. Magnetic Resonance Angiography. Male. Neoplasm Staging. Risk Assessment

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  • (PMID = 16413453.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Martin SE, Al-Khatib SM, Turner MS, Douglas-Akinwande AC, Hattab EM: A 41-year-old woman with von Hippel-Lindau and a cerebellar lesion. Brain Pathol; 2010 Mar;20(2):511-4
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  • [Title] A 41-year-old woman with von Hippel-Lindau and a cerebellar lesion.
  • MRI revealed a well-circumscribed, partially cystic cerebellar neoplasm, consistent with hemangioblastoma.
  • The tumor was resected and the diagnosis of hemangioblastoma confirmed.
  • RCC metastatic to a CNS hemangioblastoma is the second most common type of tumor-to-tumor metastasis, which may be due to a number of factors.
  • Proper immunostaining panels are required to clearly identify these cases since both tumor may have similar histology.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Cerebellar Neoplasms / pathology. Hemangioblastoma / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / diagnosis. Brain Neoplasms / pathology. Cerebellum / pathology. Diagnosis, Differential. Female. Humans. Kidney Neoplasms / pathology. Magnetic Resonance Imaging

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  • (PMID = 20438472.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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17. Zilidis G, Cadoux-Hudson TA: Recurrent dural based cystic cerebellar haemangioblastoma in a patient with von Hippel-Lindau disease. Acta Neurochir (Wien); 2007;149(4):433-6
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  • [Title] Recurrent dural based cystic cerebellar haemangioblastoma in a patient with von Hippel-Lindau disease.
  • Surgical excision of cerebellar haemangioblastomas, once they become Symptomatic, is the standard treatment in patients with von Hippel-Lindau disease.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Dura Mater / surgery. Hemangioblastoma / surgery. Meningeal Neoplasms / surgery. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Cerebellum / pathology. Cerebellum / physiopathology. Cerebellum / surgery. Female. Humans. Infratentorial Neoplasms / complications. Infratentorial Neoplasms / pathology. Infratentorial Neoplasms / surgery. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 17357827.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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18. Sherman JH, Sheehan JP, Elias WJ, Jane JA Sr: Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases. Surg Neurol; 2005 May;63(5):476-9
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  • [Title] Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases.
  • BACKGROUND: Mutism has been associated with injury to midline cerebellar structures secondary to degenerative disease, tumors, hemorrhage, or surgery.
  • Typically, cerebellar mutism syndrome (CMS) has been seen in children and only rarely described in adults after surgery of the posterior fossa.
  • CASE DESCRIPTION: The authors report on 2 patients each of whom developed cerebellar mutism after tumor resection using a posterior fossa approach.
  • The first patient underwent gross total resection of a pineal region tumor via a supracerebellar approach.
  • The second patient underwent posterior fossa decompression for a left cerebellar hemispheric renal cell carcinoma metastasis with adjacent hemorrhage.
  • One patient displayed a variant of cerebellar mutism with severe ataxic dysarthria without complete absence of speech, whereas the other demonstrated frank mutism.
  • CONCLUSION: It is paramount that neurosurgeons be aware of cerebellar mutism with regard to its very rare occurrence in adults, its time of onset, and typical self-limiting course.
  • [MeSH-major] Brain Neoplasms / surgery. Carcinoma, Renal Cell / surgery. Cerebellum / surgery. Cranial Fossa, Posterior / surgery. Dermoid Cyst / surgery. Mutism / etiology. Neurosurgical Procedures / adverse effects
  • [MeSH-minor] Adult. Cerebellar Neoplasms / physiopathology. Cerebellar Neoplasms / secondary. Cerebellar Neoplasms / surgery. Decompression, Surgical / adverse effects. Female. Humans. Kidney Neoplasms / pathology. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual. Pinealoma / pathology. Pinealoma / surgery. Postoperative Complications / etiology. Postoperative Complications / pathology. Radiosurgery. Radiotherapy. Treatment Outcome

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  • [CommentIn] Surg Neurol. 2006 Apr;65(4):424 [16531220.001]
  • (PMID = 15883080.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Selek U, Zorlu F, Hurmuz P, Cengiz M, Turker A, Soylemezoglu F, Gurkaynak M: Craniospinal radiotherapy in adult medulloblastoma. Strahlenther Onkol; 2007 May;183(5):236-40
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  • [Title] Craniospinal radiotherapy in adult medulloblastoma.
  • PURPOSE: To evaluate the outcome and prognostic factors of adult patients with medulloblastoma.
  • PATIENTS AND METHODS: 26 adult medulloblastoma patients with a median age of 27 were subjected to craniospinal radiotherapy.
  • Patient characteristics, treatment factors and tumor characteristics failed to show any significance in univariate analysis.
  • CONCLUSION: Yet, the current standard of care seems to remain craniospinal irradiation after maximal surgical resection of the primary neoplasm without clear indications for adjuvant chemotherapy.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Cranial Irradiation. Medulloblastoma / radiotherapy. Spine / radiation effects
  • [MeSH-minor] Adolescent. Adult. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17497094.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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20. Ertas G, Altundag MB, Ucer AR, Cankal F, Altundag K: Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature. J Neurooncol; 2005 Jul;73(3):273-5
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  • [Title] Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature.
  • Common manifestations of the disease are retinal, cerebellar and medullary hemangioblastomas; renal cysts and carcinomas; pancreatic cysts; pheochromocytoma; and papilllary cystadenoma of the epididym.
  • We report the case of a 40-year-old man with type I von Hippel-Lindau disease treated with external radiotherapy for recurrent cerebellar hemangioblastoma.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Hemangioblastoma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / etiology. Carcinoma, Renal Cell / surgery. Humans. Kidney Neoplasms / etiology. Kidney Neoplasms / surgery. Magnetic Resonance Imaging. Male

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  • (PMID = 15980980.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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21. Yong RL, Kavanagh EC, Fenton D, Dorovini-Zis K, Heran MK, Haw CS: Midline cerebellar medulloblastoma in a seventy-one-year-old patient. Can J Neurol Sci; 2006 Feb;33(1):101-4
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  • [Title] Midline cerebellar medulloblastoma in a seventy-one-year-old patient.
  • Hemispheric, rather than midline, cerebellar medulloblastomas are more common in older children and adults.
  • RESULTS: Histological examination showed a densely cellular neoplasm composed of small cells with a tendency towards neuroblastic rosette formation.
  • CONCLUSION: Adult medulloblastoma should be considered in the differential diagnosis of a partially calcified hyperattenuating mass within the fourth ventricle.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebral Ventricle Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Aged. Brain Neoplasms / pathology. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Fourth Ventricle / pathology. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Phosphopyruvate Hydratase / metabolism. Synaptophysin / metabolism. Tomography, X-Ray Computed

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  • (PMID = 16583731.001).
  • [ISSN] 0317-1671
  • [Journal-full-title] The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • [ISO-abbreviation] Can J Neurol Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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22. Weber DC, Miller RC, Villà S, Hanssens P, Baumert BG, Castadot P, Varlet P, Abacioglu U, Igdem S, Szutowicz E, Nishioka H, Hofer S, Rutz HP, Ozsahin M, Taghian A, Mirimanoff RO: Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network. Int J Radiat Oncol Biol Phys; 2006 Sep 1;66(1):179-86
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  • [Title] Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network.
  • PURPOSE: The aim of this study was to assess the outcome in patients with cerebellar glioblastoma (GBM) treated in 15 institutions of the Rare Cancer Network.
  • METHODS AND MATERIALS: Data from a series of 45 adult patients with cerebellar GBM were collected in a retrospective multicenter study.
  • RESULTS: The 1-year and 2-year actuarial overall survival rate was 37.8% and 14.7%, respectively, and was significantly influenced by salvage treatment (p = 0.048), tumor volume (p = 0.044), extent of neurosurgical resection (p = 0.019), brainstem invasion (p = 0.0013), additional treatment after surgery (p < 0.001), and completion of the initial treatment (p < 0.001) on univariate analysis.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Glioblastoma / radiotherapy. Rare Diseases / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy / methods. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 16814953.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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23. Capovilla M, Kambouchner M, Bernier M, Soulier A, Tissier F, Saintigny P: Late cerebellar relapse of a juvenile bronchial carcinoid. Clin Lung Cancer; 2007 Mar;8(5):339-41
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  • [Title] Late cerebellar relapse of a juvenile bronchial carcinoid.
  • Although epithelial bronchial neoplasm is a cancer frequently observed in adult patients, it is rarely observed in patients who are children.
  • The most frequent histologic subtype is well differentiated neuroendocrine tumor, or carcinoid.
  • They have a variable biologic behavior, ranging from benign to malignant tumors capable of very late recurrence or metastasis.
  • We report the case of a child with a pulmonary carcinoid initially considered typical, who presented with relapse in the cerebellum and mediastinum 16 years later.
  • After review of the pathology slides, primary and metastatic tumors were reclassified as atypical carcinoid according to the criteria of the 2004 World Health Organization classification of lung tumors.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / secondary
  • [MeSH-minor] Adolescent. Adult. Humans. Male

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  • (PMID = 17562235.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Glassmann A, Molly S, Surchev L, Nazwar TA, Holst M, Hartmann W, Baader SL, Oberdick J, Pietsch T, Schilling K: Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells. BMC Dev Biol; 2007;7:111
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  • [Title] Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells.
  • BACKGROUND: Mtss1 encodes an actin-binding protein, dysregulated in a variety of tumors, that interacts with sonic hedgehog/Gli signaling in epidermal cells.
  • Given the prime importance of this pathway for cerebellar development and tumorigenesis, we assessed expression of Mtss1 in the developing murine cerebellum and human medulloblastoma specimens.
  • In the adult CNS, Mtss1 is found exclusively in cerebellar Purkinje cells.
  • Whereas immature granule cells express a Mtss1 variant observed also in peripheral tissues and comprising exon 12, this exon is replaced by a CNS-specific exon, 12a, in more mature granule cells and in adult Purkinje cells.
  • Bioinformatic analysis of Mtss1 suggests that differential exon usage may affect interaction with Fyn and Src, two tyrosine kinases previously recognized as critical for cerebellar cell migration and histogenesis.
  • CONCLUSION: Both the pattern of expression and splicing of Mtss1 is developmentally regulated in the murine cerebellum.
  • These findings are discussed with a view on the potential role of Mtss1 for cytoskeletal dynamics in developing and mature cerebellar neurons.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Cerebellum / growth & development. Gene Expression Regulation, Developmental. Microfilament Proteins / genetics. Neoplasm Proteins / genetics
  • [MeSH-minor] Animals. Cerebellar Neoplasms / pathology. Exons. Humans. Mice. Mice, Inbred C57BL. Mice, Transgenic. Polymerase Chain Reaction. Protein Splicing / genetics. Purkinje Cells / pathology. Tumor Cells, Cultured

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  • (PMID = 17925019.001).
  • [ISSN] 1471-213X
  • [Journal-full-title] BMC developmental biology
  • [ISO-abbreviation] BMC Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Microfilament Proteins; 0 / Mtss1 protein, mouse; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2194783
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25. Pettorini BL, Narducci A, de Carlo A, Abet F, Caldarelli M, Massimi L, Tamburrini G, Di Rocco C: Thyroid neoplasm after central nervous system irradiation for medulloblastoma in childhood: report of two cases. Childs Nerv Syst; 2009 May;25(5):631-4
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  • [Title] Thyroid neoplasm after central nervous system irradiation for medulloblastoma in childhood: report of two cases.
  • However, only a few papers on radioinduced thyroid neoplasms after CNS irradiation have been published in the literature.
  • We report on two additional cases of thyroid neoplasms following childhood CNS irradiation for the treatment of a posterior fossa medulloblastoma.
  • [MeSH-major] Carcinoma, Papillary / etiology. Cerebellar Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Medulloblastoma / radiotherapy. Neoplasms, Radiation-Induced / etiology. Thyroid Neoplasms / etiology
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Young Adult

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  • (PMID = 19225785.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Rushing EJ, Smith AB, Smirniotopoulos JG, Douglas AF, Zeng W, Azumi N: Occult leptomeningeal large cell medulloblastoma in an adult. Clin Neuropathol; 2009 May-Jun;28(3):188-92
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  • [Title] Occult leptomeningeal large cell medulloblastoma in an adult.
  • We report the first case of this entity in an adult that proved to be an unsuspected primary leptomeningeal tumor.
  • Postmortem examination of the brain was notable for necrotic cerebellar tonsils, but demonstrated no evidence of an intraparenchymal mass lesion.
  • Microscopic examination of the cerebellum revealed discohesive neoplastic cells, which showed characteristic dot-like immunoreactivity for synaptophysin, diagnostic of large cell medulloblastoma within the subarachnoid space.
  • CONCLUSIONS: Our experience with this unique case illustrates the challenges of diagnosing a primary leptomeningeal neoplasm.
  • This case also underscores the importance of maintaining a high degree of suspicion for leptomeningeal neoplasms in patients who present with imaging studies suspicious for Chiari I malformation.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology. Meningeal Neoplasms / pathology
  • [MeSH-minor] Adult. Arnold-Chiari Malformation / complications. Fatal Outcome. Humans. Intervertebral Disc Displacement / complications. Magnetic Resonance Imaging. Male

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  • (PMID = 19537136.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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27. Donovan DJ, Iskandar JI, Citrone MJ, Royer MC: Successful removal of a cerebellar hemangioblastoma in a combat support hospital. Mil Med; 2006 Mar;171(3):211-5
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  • [Title] Successful removal of a cerebellar hemangioblastoma in a combat support hospital.
  • Imaging studies revealed a cystic brain neoplasm causing hydrocephalus and increased intracranial pressure.
  • The tumor was completely removed and the patient's symptoms resolved, allowing safe evacuation.
  • This is the first reported case of a brain tumor successfully removed in a CSH.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Hemangioblastoma / surgery. Hospitals, Military. Hospitals, Packaged. Military Medicine. Military Personnel. Warfare
  • [MeSH-minor] Adult. Humans. Kuwait. Male. Tomography, X-Ray Computed. Treatment Outcome. United States

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  • (PMID = 16602518.001).
  • [ISSN] 0026-4075
  • [Journal-full-title] Military medicine
  • [ISO-abbreviation] Mil Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Germanwala AV, Mai JC, Tomycz ND, Niranjan A, Flickinger JC, Kondziolka D, Lunsford LD: Boost Gamma Knife surgery during multimodality management of adult medulloblastoma. J Neurosurg; 2008 Feb;108(2):204-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Boost Gamma Knife surgery during multimodality management of adult medulloblastoma.
  • OBJECT: The aim of this paper was to determine prognostic factors for adult medulloblastoma treated with boost Gamma Knife surgery (GKS) following resection and craniospinal irradiation.
  • METHODS: The authors performed a retrospective analysis of 12 adult patients with histologically proven medulloblastoma or supratentorial primitive neuroectodermal tumor who between February 1991 and December 2004 underwent >or=1 sessions of GKS for posttreatment residual or recurrent tumors (6 tumors in each group).
  • Stereotactic radiosurgery was applied to residual and recurrent posterior fossa tumor as well as to foci of intracranial medulloblastoma metastases.
  • The mean GKS-treated tumor volume was 9.4 cm3 (range 0.5-39 cm3).
  • RESULTS: Following adjunctive radiosurgery, 5 patients had no evidence of tumor on magnetic resonance (MR) imaging, 3 patients had stable tumor burden on MR imaging, and 4 patients had evidence of tumor progression locally with or without intracranial metastases.
  • All patients with tumor progression died.
  • The majority of patients who achieved tumor eradication (80%) and tumor stabilization (67%) after GKS had residual tumor as the reason for their referral for GKS.
  • The best outcomes were attained in patients with residual disease who were younger, had smaller tumor volumes, had no evidence of metastatic disease, and had received higher cumulative GKS doses.
  • CONCLUSIONS: Single or multiple GKS sessions were a well-tolerated, feasible, and effective adjunctive treatment for posterior fossa residual or recurrent medulloblastoma as well as intracranial metastatic medulloblastoma in adult patients.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Medulloblastoma / surgery. Neoadjuvant Therapy. Radiosurgery / methods
  • [MeSH-minor] Adult. Age Factors. Chemotherapy, Adjuvant. Cranial Irradiation. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual. Neuroectodermal Tumors / radiotherapy. Neuroectodermal Tumors / surgery. Remission Induction. Retrospective Studies. Spine / radiation effects. Supratentorial Neoplasms / radiotherapy. Supratentorial Neoplasms / surgery. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 18240913.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Chargari C, Feuvret L, Levy A, Lamproglou I, Assouline A, Hemery C, Ghorbal L, Lopez S, Tep B, G GB, Lang P, Laigle-Donadey F, Cornu P, Mazeron JJ, Simon JM: Reappraisal of clinical outcome in adult medulloblastomas with emphasis on patterns of relapse. Br J Neurosurg; 2010 Aug;24(4):460-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reappraisal of clinical outcome in adult medulloblastomas with emphasis on patterns of relapse.
  • BACKGROUND: Clinical outcome and prognostic factors were assessed in adult medulloblastoma patients, with emphasis on patterns of relapse.
  • PATIENTS AND METHODS: Records of 36 consecutive adult patients with medulloblastoma were reviewed.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant / methods. Disease-Free Survival. Female. Humans. Magnetic Resonance Angiography. Male. Middle Aged. Outcome Assessment (Health Care). Prognosis. Radiotherapy, Adjuvant / methods. Young Adult

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  • (PMID = 20726753.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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30. Kleinschmidt-Demasters BK, Cummings TJ, Hulette CM, Morgenlander JC, Corboy JR: Adult cases of leukoencephalopathy, cerebral calcifications, and cysts: expanding the spectrum of the disorder. J Neuropathol Exp Neurol; 2009 Apr;68(4):432-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult cases of leukoencephalopathy, cerebral calcifications, and cysts: expanding the spectrum of the disorder.
  • Leukoencephalopathy with cerebral calcifications and cysts (LCC) was first reported in children who developed cognitive decline and variable extrapyramidal, cerebellar, and pyramidal signs, with or without seizures.
  • Leukoencephalopathy with cerebral calcifications and cysts is characterized by progressive formation of brain cysts that can generate a mass effect simulating a neoplasm.
  • We report 2 additional adult-onset cases of LCC.
  • These cases expand the spectrum of adult-onset LCC, the etiology of which is unknown.
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 19287308.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Smee RI, Williams JR: Medulloblastomas-primitive neuroectodermal tumours in the adult population. J Med Imaging Radiat Oncol; 2008 Feb;52(1):72-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medulloblastomas-primitive neuroectodermal tumours in the adult population.
  • [MeSH-major] Cerebellar Neoplasms / epidemiology. Medulloblastoma / epidemiology. Neuroectodermal Tumors, Primitive / epidemiology
  • [MeSH-minor] Adolescent. Adult. Databases, Factual / statistics & numerical data. Female. Follow-Up Studies. Humans. Intracranial Pressure. Male. Neoplasm Recurrence, Local. Neurosurgical Procedures. New South Wales / epidemiology. Radiotherapy, Adjuvant. Rare Diseases. Retrospective Studies. Treatment Outcome

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  • (PMID = 18373831.001).
  • [ISSN] 1754-9477
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 29
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32. Poelen J, Bernsen HJ, Prick MJ: Metastatic medulloblastoma in an adult; treatment with temozolomide. Acta Neurol Belg; 2007 Jun;107(2):51-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic medulloblastoma in an adult; treatment with temozolomide.
  • A medulloblastoma at adult age is extremely rare, and there is no overall accepted treatment, especially not in the case of a relapse.
  • This observation encouraged us to decide to treat an adult patient with a recurrent medulloblastoma with temozolomide.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Cerebellar Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / secondary

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  • (PMID = 17710841.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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33. Durando X, Thivat E, Gilliot O, Irthum B, Verrelle P, Vincent C, Bay JO: Temozolomide treatment of an adult with a relapsing medulloblastoma. Cancer Invest; 2007 Sep;25(6):470-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temozolomide treatment of an adult with a relapsing medulloblastoma.
  • Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors.
  • Here, we report the use of temozolomide in an adult presenting relapsing medulloblastoma.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Cerebellar Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome

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  • (PMID = 17882660.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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34. Mekni A, Chelly I, Haouet S, Zitouna M, Kchir N: [Malignant cerebellar ganglioglioma. A case report and review of the literature]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):119-22
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  • [Title] [Malignant cerebellar ganglioglioma. A case report and review of the literature].
  • Ganglioglioma is usually a well differentiated slowly growing mixed neuronal and glial neoplasm corresponding to WHO grade I or II.
  • We report a case of a 25-year-old woman with a family history of neurofibromatosis who presented initially with a World Health Organization grade IV anaplastic ganglioglioma (a mixed ganglion cell multiform tumor glioblastoma).
  • Immunohistochemical analysis clearly distinguished the two tumor cell populations.
  • It also documents the aggressive biologic behavior of this complex neoplasm.
  • [MeSH-major] Ganglioglioma / pathology. Infratentorial Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Immunohistochemistry. Neurofibromatoses / genetics. Tomography, X-Ray Computed

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  • (PMID = 16840971.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. García Casales Z, Echebarría Barona A, Urberuaga Pascual A, Astigarraga Aguirre I, Burgos Bretones JJ, Navajas Gutiérrez A: [Differential aspects in children and adult patients with medulloblastoma]. Med Clin (Barc); 2009 Oct 3;133(12):454-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Differential aspects in children and adult patients with medulloblastoma].
  • [Transliterated title] Meduloblastoma: aspectos diferenciales entre el tumor infantil y del adulto.
  • BACKGROUND AND OBJECTIVE: Medulloblastoma is the more frequent malignant cerebral tumor in childhood.
  • Tumor site and mortality according to initial dissemination were variables of statistic significance.
  • Sequelae were detected in 100% of the survivors, mainly with cerebellar and ocular alterations.
  • [MeSH-major] Cerebellar Neoplasms. Medulloblastoma
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Cohort Studies. Confidence Intervals. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Neoplasm Metastasis. Normal Distribution. Retrospective Studies. Spain / epidemiology. Statistics, Nonparametric. Time Factors

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  • (PMID = 19674760.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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36. Furuse M, Miyatake SI, Kuroiwa T: Cavernous malformation after radiation therapy for astrocytoma in adult patients: report of 2 cases. Acta Neurochir (Wien); 2005 Oct;147(10):1097-101; discussion 1101
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  • [Title] Cavernous malformation after radiation therapy for astrocytoma in adult patients: report of 2 cases.
  • We describe two adult patients with cavernous malformation after irradiation for astrocytoma.
  • Radiation-induced cavernous malformations are rare in adult patients with astrocytoma.
  • [MeSH-major] Astrocytoma / radiotherapy. Blood Vessels / pathology. Blood Vessels / radiation effects. Brain Neoplasms / radiotherapy. Hemangioma, Cavernous, Central Nervous System / etiology. Neoplasms, Radiation-Induced / etiology. Radiotherapy / adverse effects
  • [MeSH-minor] Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / radiotherapy. Dementia / diagnosis. Dementia / etiology. Dementia / physiopathology. Frontal Lobe / blood supply. Frontal Lobe / pathology. Frontal Lobe / radiation effects. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Temporal Lobe / blood supply. Temporal Lobe / pathology. Temporal Lobe / radiation effects. Tomography, X-Ray Computed

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  • (PMID = 16021386.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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37. Crabtree KL, Arnold PM: Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously. Pediatr Neurosurg; 2010;46(1):66-70
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  • [Title] Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously.
  • We report a 26-year-old male with an intradural extramedullary PA at the thoracolumbar junction following subtotal cerebellar PA resection 18 years previously.
  • To our knowledge, this is the longest time reported from initial tumor resection of leptomeningeal dissemination to the distal spinal cord.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Meningeal Neoplasms / secondary. Neoplasm Seeding. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Child. Follow-Up Studies. Humans. Laminectomy. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Thoracic Vertebrae. Time Factors

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516744.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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38. Shah MN, Leonard JR, Perry A: Rosette-forming glioneuronal tumors of the posterior fossa. J Neurosurg Pediatr; 2010 Jan;5(1):98-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rosette-forming glioneuronal tumors of the posterior fossa.
  • Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare, recently described WHO Grade I neoplasm.
  • The authors report 6 examples of RGNT arising primarily from the cerebellar vermis.
  • The original diagnoses included pilocytic astrocytoma, ependymoma, cerebellar dysembryoplastic neuroepithelial tumor (DNT), and oligodendroglioma.
  • These cases expand the known clinical and histological spectrum of this rare tumor type.
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / surgery. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / surgery. Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Cranial Fossa, Posterior. Ependymoma / diagnosis. Ependymoma / surgery. Magnetic Resonance Imaging. Neuroectodermal Tumors, Primitive / diagnosis. Oligodendroglioma / diagnosis. Oligodendroglioma / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / surgery. Teratoma / diagnosis. Teratoma / surgery
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Female. Humans. Middle Aged

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  • (PMID = 20043744.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Ang C, Hauerstock D, Guiot MC, Kasymjanova G, Roberge D, Kavan P, Muanza T: Characteristics and outcomes of medulloblastoma in adults. Pediatr Blood Cancer; 2008 Nov;51(5):603-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Adult medulloblastoma is a rare disease for which there is no internationally accepted standard of care.
  • We sought to review the presentation, management, and outcome of patients with adult medulloblastoma treated at the McGill University teaching hospitals over the past 18 years.
  • METHODS: Medical records were reviewed to gather demographic and clinical data including presenting symptoms, tumor characteristics, management, survival, and treatment toxicity.
  • CONCLUSION: Adult medulloblastoma has distinct characteristics from the pediatric population including presentation in the lateral cerebellar hemispheres.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / therapy. Medulloblastoma / pathology. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Chemotherapy, Adjuvant / adverse effects. Combined Modality Therapy. Cranial Irradiation. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Neurosurgical Procedures. Radiotherapy, Adjuvant / adverse effects. Salvage Therapy / methods. Treatment Outcome

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18649371.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Peltier J, Lok C, Fichten A, Bruniau A, Lefranc M, Toussaint P, Desenclos C, Le Gars D: Lhermitte-Duclos disease and Cowden's syndrome. Report of two cases. Neurochirurgie; 2006 Nov;52(5):407-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE AND IMPORTANCE: Lhermitte-Duclos disease, or dysplastic cerebellar gangliocytoma is a rare entity characterized by a hamartomatous lesion in the posterior fossa.
  • Cowden's syndrome, or hamartoma-neoplasia syndrome is a rare underdiagnosed autosomal dominant genodermatosis with high incidence of malignant tumors.
  • CLINICAL PRESENTATION: We report two cases of Lhermitte-Duclos and Cowden disease occurring in adult patients.
  • An asymptomatic 38-year-old male had bilateral optic nerve drusen related to a cerebellar neoplasm.
  • A conservative strategy can be chosen without neurological signs because of slow tumor growth.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Ganglioneuroma / pathology. Ganglioneuroma / surgery. Hamartoma Syndrome, Multiple / pathology. Hamartoma Syndrome, Multiple / surgery
  • [MeSH-minor] Adult. Female. Fibrocystic Breast Disease / etiology. Fibrocystic Breast Disease / physiopathology. Goiter / complications. Humans. Intracranial Hypertension / etiology. Intracranial Hypertension / physiopathology. Magnetic Resonance Imaging. Male. Neurocutaneous Syndromes / pathology. Pedigree. Syndrome

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  • (PMID = 17185946.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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41. Gauchotte G, Baylac F, Marie B, Vignaud JM: [Medullomyoblastoma: a medulloblastoma with rhabdomyoblastic differentiation]. Ann Pathol; 2010 Apr;30(2):135-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 26 years old patient was operated for a tumor of cerebellar vermix, and then reoperated for a relapse at the age of 35 years, with a similar histological pattern in both cases.
  • At pathologic examination, the tumor was composed of hypercellular sheets typical of medulloblastoma, containing also sparse large cells with eosinophilic cytoplasm and round nuclei containing voluminous nucleoli.
  • The main differential diagnoses are atypical teratoid/rhabdoid tumor, immature teratoma, medulloepithelioma, primitive intracranial rhabdomyosarcoma and myoneurocytoma.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cell Differentiation. Desmin / analysis. Disease Progression. Fatal Outcome. Humans. Male. Muscle Cells / chemistry. Muscle Cells / pathology. Myogenin / analysis. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local / chemistry. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurofilament Proteins / analysis. Rhabdomyosarcoma / pathology. Synaptophysin / analysis

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20451073.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Myogenin; 0 / Neoplasm Proteins; 0 / Neurofilament Proteins; 0 / Synaptophysin
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42. Ertas G, Ucer AR, Altundag MB, Durmus S, Calikoglu T, Ozbagi K, Abanuz H, Altundag K, Demirkasimoglu A: Medulloblastoma/primitive neuroectodermal tumor in adults: prognostic factors and treatment results: a single-center experience from Turkey. Med Oncol; 2008;25(1):69-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medulloblastoma/primitive neuroectodermal tumor in adults: prognostic factors and treatment results: a single-center experience from Turkey.
  • We performed retrospective review of 29 adult patients with cerebellar medulloblastoma/primitive neuroectodermal tumor (PNET) who received craniospinal radiotherapy in Ankara Oncology Hospital between years 2000 and 2005.
  • In conclusion, adult patients with PNET have worse survival rates than patients with medulloblastoma, like in childhood patients.
  • [MeSH-major] Cerebellar Neoplasms / mortality. Medulloblastoma / mortality
  • [MeSH-minor] Adult. Female. Humans. Male. Neoplasm Recurrence, Local. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 18188718.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Razak AR, Nasser Q, Morris P, Alcutt D, Grogan L: Medulloblastoma in two successive pregnancies. J Neurooncol; 2005 May;73(1):89-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 24-year old primaparous female at 20 weeks gestation presented acutely with cerebellar symptoms.
  • Magnetic resonance imaging brain showed evidence of a cerebellar vermis lesion.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Etoposide / therapeutic use. Female. Humans. Ifosfamide / therapeutic use. Pregnancy. Treatment Outcome. Vincristine / therapeutic use

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  • (PMID = 15933823.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; UM20QQM95Y / Ifosfamide; IVAD protocol
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44. Rorke-Adams LB, Portnoy H: Long-term survival of an infant with gliomatosis cerebelli. J Neurosurg Pediatr; 2008 Nov;2(5):346-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gliomatosis cerebri is an uncommon but well-established central nervous system neoplasm that occurs primarily in adults.
  • Although the neoplastic process typically arises in the cerebrum, it often spreads to brainstem, cerebellum, or even the spinal cord.
  • In this report the authors document the surgical treatment of a 13-month-old boy whose tumor arose in the cerebellum and over time extended to the thalamus where its growth halted at age 3 years and 10 months.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Neoplasms, Neuroepithelial / pathology. Neoplasms, Neuroepithelial / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Humans. Infant. Male. Neoplasm Invasiveness. Treatment Outcome

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  • (PMID = 18976105.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Kalina P, Decker A, Kornel E, Halperin JJ: Lyme disease of the brainstem. Neuroradiology; 2005 Dec;47(12):903-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Magnetic resonance imaging (MRI) and positron emission tomography (PET) suggested a brainstem neoplasm.
  • We describe Lyme disease involvement of the cerebellar peduncles with hypermetabolism on PET.
  • [MeSH-major] Cerebellum / microbiology. Cerebellum / pathology. Lyme Disease / complications
  • [MeSH-minor] Adult. Cerebellar Neoplasms / diagnosis. Female. Fluorodeoxyglucose F18. Humans. Magnetic Resonance Imaging. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 16158278.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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46. Saikali S, Le Strat A, Heckly A, Stock N, Scarabin JM, Hamlat A: Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature. J Neurosurg; 2005 Feb;102(2):376-81
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  • Although the occipital lesion was cured surgically, the cerebellar tumor recurred three times and underwent malignant transformation into an anaplastic oligodendroglioma.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Neurofibromatosis 1 / surgery
  • [MeSH-minor] Adult. Brain / pathology. Brain / surgery. Cell Transformation, Neoplastic / pathology. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellum / pathology. Cerebellum / surgery. Disease Progression. Female. Humans. Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Occipital Lobe / pathology. Occipital Lobe / surgery. Oligodendroglioma / pathology


47. Chelly I, Mekni A, Kchir N, Karim BH, Khadija B, Selma B, Slim H, Khaldi M, Zitouna M: Intracerebellar granulocytic sarcoma. A case report. Pathologica; 2005 Oct;97(5):335-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case of cerebellar granulocytic sarcoma occuring in a 43 years old woman without any precedent medical history.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Sarcoma, Myeloid / pathology
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / analysis. Carboxylic Ester Hydrolases / analysis. Fatal Outcome. Female. Headache / etiology. Hepatomegaly / etiology. Humans. Immunoenzyme Techniques. Muramidase / analysis. Neoplasm Proteins / analysis. Peroxidase / analysis. Splenomegaly / etiology. Staining and Labeling

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  • (PMID = 16480032.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / Neoplasm Proteins; EC 1.11.1.7 / Peroxidase; EC 3.1.1.- / Carboxylic Ester Hydrolases; EC 3.1.1.- / chloroacetate esterase; EC 3.2.1.17 / Muramidase
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48. El-Bahy K: Telovelar approach to the fourth ventricle: operative findings and results in 16 cases. Acta Neurochir (Wien); 2005 Feb;147(2):137-42; discussion 142

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cerebellar mutism was not observed in any patient and there was no mortality.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellum / pathology. Cerebellum / surgery. Fourth Ventricle / pathology. Fourth Ventricle / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / pathology. Astrocytoma / surgery. Cerebellar Ataxia / etiology. Cerebellar Ataxia / pathology. Cerebellar Ataxia / physiopathology. Child. Choroid Plexus / pathology. Choroid Plexus / surgery. Cranial Fossa, Posterior / surgery. Dermoid Cyst / pathology. Dermoid Cyst / surgery. Ependymoma / pathology. Ependymoma / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Medulloblastoma / pathology. Medulloblastoma / surgery. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Papilloma, Choroid Plexus / pathology. Papilloma, Choroid Plexus / surgery. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / physiopathology. Retrospective Studies. Treatment Outcome

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  • (PMID = 15605202.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Austria
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49. Gomy I, Molfetta GA, de Andrade Barreto E, Ferreira CA, Zanette DL, Casali-da-Rocha JC, Silva WA Jr: Clinical and molecular characterization of Brazilian families with von Hippel-Lindau disease: a need for delineating genotype-phenotype correlation. Fam Cancer; 2010 Dec;9(4):635-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary cancer syndrome that predisposes to the development of a variety of benign and malignant tumours, especially cerebellar haemangioblastomas, retinal angiomas and clear-cell renal cell carcinomas (RCC).
  • Eighteen of twenty patients from ten unrelated families underwent genetic testing, nine of them fulfilled VHL disease criteria and one had an apparently sporadic cerebellar haemangioblastoma.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Gene Deletion. Kidney Neoplasms / genetics. Mutation / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics. von Hippel-Lindau Disease / genetics
  • [MeSH-minor] Adolescent. Adult. Brazil. Case-Control Studies. Cerebellar Neoplasms / complications. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Child. DNA Mutational Analysis. DNA, Neoplasm / genetics. Family. Female. Genetic Association Studies. Genetic Predisposition to Disease. Genotype. Humans. Introns. Male. Pedigree. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length. Risk Factors. Young Adult

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  • (PMID = 20567917.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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50. Misaki K, Marukawa K, Hayashi Y, Fukusato T, Minamoto T, Hasegawa M, Yamashita J, Fujisawa H: Correlation of gamma-catenin expression with good prognosis in medulloblastomas. J Neurosurg; 2005 Mar;102(2 Suppl):197-206
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: Medulloblastoma is a malignant cerebellar tumor of childhood and is difficult to cure due to frequent cerebrospinal fluid dissemination.
  • Molecules on the Wnt signal pathway in primary tumors were examined.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cytoskeletal Proteins / genetics. Genes, myc / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Antibodies, Neoplasm / immunology. Blotting, Western. Child. Child, Preschool. Combined Modality Therapy. DNA Mutational Analysis. DNA Primers / genetics. Desmoplakins. Genes, bcl-1 / immunology. Humans. Immunohistochemistry. Infant. Point Mutation / genetics. Polymerase Chain Reaction. Prognosis. RNA, Messenger / genetics. Trans-Activators / genetics. Trans-Activators / immunology. beta Catenin. gamma Catenin

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  • (PMID = 16156230.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / DNA Primers; 0 / Desmoplakins; 0 / JUP protein, human; 0 / RNA, Messenger; 0 / Trans-Activators; 0 / beta Catenin; 0 / gamma Catenin
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51. Phi JH, Park SH, Chung CK, Wang KC, Cho BK, Kim SK: Atypical cell clusters expressing both neuronal and oligodendrocytic markers: novel histological pattern of glioneuronal tumors? Pathol Int; 2009 Oct;59(10):735-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical cell clusters expressing both neuronal and oligodendrocytic markers: novel histological pattern of glioneuronal tumors?
  • Glioneuronal tumors are a group of brain tumors that consist of both neuronal and glial cells.
  • The spectrum of glioneuronal tumors is currently expanding, and many atypical glioneuronal tumors require further characterization.
  • Two patients are described who had an atypical glioneuronal tumor with peculiar pathological features.
  • One patient was a 7-year-old girl with a tumor in the right cerebellar hemisphere.
  • The other was a 37-year-old man with a tumor in the spinal cord.
  • Although the clinical features (age at diagnosis, tumor location, and recurrence) were very different in these patients, the tumors had a characteristic common feature of atypical cell clusters.
  • Intriguingly, the tumor cells in the clusters expressed both neuronal and oligodendroglial markers, indicating aberrant differentiation.
  • Furthermore, the cluster-forming cells had modest proliferative indices and CD133 expression, indicating their role in the growth of the tumor.
  • It is believed that these atypical cell clusters are a novel pattern of differentiation of glioneuronal tumors and that they need further investigation.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cerebellar Neoplasms / pathology. Ganglioglioma / pathology. Neurons / pathology. Oligodendroglia / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Child. Disease-Free Survival. Female. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Treatment Outcome

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  • (PMID = 19788619.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Spiller SE, Ravanpay AC, Hahn AW, Olson JM: Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma. J Neurooncol; 2006 Sep;79(3):259-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Suberoylanilide hydroxamic acid (SAHA) has been studied in adult solid and hematologic malignancies.
  • However, little information has been reported on the effects of SAHA on central nervous system (CNS) tumors including medulloblastoma, the most common malignant brain tumor in children.
  • EXPERIMENTAL DESIGN AND RESULTS: Tissue culture studies were performed treating primary human fibroblasts, established medulloblastoma cell lines, and primary human medulloblastoma tumors with SAHA.
  • In athymic mice with medulloblastoma xenograft tumors, oral SAHA resulted in apoptosis of tumor tissue and significantly slowed tumor growth.
  • In the ND2:Smo transgenic mouse medulloblastoma model, SAHA treatment caused significant apoptosis in these cerebellar tumors.
  • CONCLUSIONS: SAHA effectively induces cell death in established medulloblastoma cell lines, human patient primary tumor cultures, medulloblastoma xenografts and intracranial spontaneous medulloblastomas.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cerebellar Neoplasms / drug therapy. Hydroxamic Acids / pharmacology. Medulloblastoma / drug therapy
  • [MeSH-minor] Animals. Apoptosis / drug effects. Cells, Cultured. Child. Fibroblasts / drug effects. Humans. In Situ Nick-End Labeling. Mice. Mice, Nude. Neoplasm Transplantation. Neoplasms, Experimental / drug therapy

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  • (PMID = 16645722.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA112350-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Hydroxamic Acids; 58IFB293JI / vorinostat
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53. Izycka-Swieszewska E, Szurowska E, Kloc W, Rzepko R, Dubaniewicz-Wybieralska M, Skorek A, Drozyńska E, Stempniewicz M: Cerebellopontine angle tumours: radiologic-pathologic correlation and diagnostic difficulties. Folia Neuropathol; 2006;44(4):274-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellopontine angle tumours: radiologic-pathologic correlation and diagnostic difficulties.
  • A group of 119 cases of cerebellopontine angle (CPA) tumours was studied looking at the pathological composition, relative incidence of tumour types, their radiological features and the pathological-radiological correlations.
  • Tumours with preoperative radiological diagnosis and verified pathologically were analyzed.
  • Histopathologically the material consisted of 77 schwannomas and 42 non-acoustic tumours.
  • Radiological retrospective evaluation of CT and/or MRI documentation was performed in 84 patients.
  • The tumours were classified according to Koos's staging scale.
  • Diagnostic discrepancies (histopathological vs radiological) according to the clinical stage of CPA tumours were analyzed.
  • In our series non-acoustic tumours made up 37% of CPA lesions.
  • Sharp tumour-pyramis angle and intracanalicular fraction are not exclusive features of schwannomas.
  • Tumours in stage IV are the most heterogeneous and diagnostically difficult group.

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  • (PMID = 17183454.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
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54. Tchoghandjian A, Fernandez C, Colin C, El Ayachi I, Voutsinos-Porche B, Fina F, Scavarda D, Piercecchi-Marti MD, Intagliata D, Ouafik L, Fraslon-Vanhulle C, Figarella-Branger D: Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature. Brain; 2009 Jun;132(Pt 6):1523-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These tumours affect preferentially the cerebellum (benign clinical course) and the optic pathway, especially the hypothalamo-chiasmatic region (poor prognosis).
  • We used the microarray technique to compare the transcriptional profiles of five hypothalamo-chiasmatic and six cerebellar pilocytic astrocytomas.
  • Results demonstrate that cerebellar and hypothalamo-chiasmatic pilocytic astrocytomas are two genetically distinct and topography-dependent entities.
  • [MeSH-major] Astrocytoma / diagnosis. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Astrocytes / metabolism. Cell Proliferation. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Child. Child, Preschool. DNA, Neoplasm / genetics. Diagnosis, Differential. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Humans. Hypothalamus / metabolism. Infant. Middle Aged. Neoplastic Stem Cells / pathology. Neuroglia / pathology. Oligonucleotide Array Sequence Analysis / methods. Optic Chiasm / cytology. Optic Chiasm / embryology. Optic Chiasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Up-Regulation. Vimentin / metabolism. Young Adult

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  • (PMID = 19336457.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Vimentin
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55. Sun YJ, Yu SZ, Sun CY, Wang Q, Jin SM, Wu WX, An TL: [Detection of chromosomal DNA imbalance in medulloblastoma by comparative genomic hybridization]. Zhonghua Bing Li Xue Za Zhi; 2010 Sep;39(9):606-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eleven gain zones (+5q, +6q, +7q, +11q, +15q, +17p, +17q, +19q, +20q, +21q, +Xp) and twenty-five loss zones (-1p, -1q, -2p, -2q, -3q, -4p, -6p, -6q, -8p, -8q, -10p, -10q, -11p, -14q, -16p, -16q, -17p, -18p, -18q, -19p, -19q, -20p, -20q, -Xp, -Xq) were detected in those tumors.
  • +7q, +17q, -14q and -10q correlate closely to development of the tumors.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Chromosome Deletion. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Comparative Genomic Hybridization. DNA, Neoplasm / genetics. Female. Humans. Male. Sex Factors. Young Adult

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  • (PMID = 21092588.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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56. Luan S, Zhuang D, Sun L, Huang FP: Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: Case report and review of literature. Clin Neurol Neurosurg; 2010 May;112(4):362-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: Case report and review of literature.
  • Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle has been identified as a novel and distinctive type of primary central nervous system neoplasm.
  • In this report, we present a case with RGNT arising from the right cerebellar hemisphere.
  • RGNT of the fourth ventricle is a rare, benign tumor with an excellent prognosis.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Glioma / pathology. Rosette Formation
  • [MeSH-minor] Adult. Cerebellar Neoplasms / pathology. Cerebellum / pathology. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures. Treatment Outcome

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  • [Copyright] Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20133047.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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57. Kano T, Ikota H, Wada H, Iwasa S, Kurosaki S: A case of an anaplastic ependymoma with gliosarcomatous components. Brain Tumor Pathol; 2009;26(1):11-7
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  • Computed tomography revealed a large cystic lesion with a mural nodule-like mass homogeneously enhanced with contrast medium in the right cerebellum.
  • The tumor was removed, and pathological studies revealed a cerebellar astrocytoma corresponding to World Health Organization grade II.
  • When she was 35 years old, or 6 years after the surgery, magnetic resonance imaging revealed a recurrence of the tumor in the right cerebellum, and subtotal removal of the recurrent tumor was performed.
  • Thereafter, at 39 years of age, or 4 years after radiation therapy, magnetic resonance imaging again revealed a recurrence of the tumor, which was heterogeneously enhanced with gadoliniumdiethylenetriamine pentaacetic acid in the right cerebellum.
  • Subtotal removal of the tumor was performed; pathological studies revealed an anaplastic ependymoma with sarcomatous components.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Ependymoma / pathology. Gliosarcoma / pathology
  • [MeSH-minor] Adult. Astrocytoma / pathology. Astrocytoma / surgery. Female. Glial Fibrillary Acidic Protein / metabolism. Headache / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Paraffin Embedding. Tomography, X-Ray Computed

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  • (PMID = 19408092.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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58. Korah MP, Esiashvili N, Mazewski CM, Hudgins RJ, Tighiouart M, Janss AJ, Schwaibold FP, Crocker IR, Curran WJ Jr, Marcus RB Jr: Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma. Int J Radiat Oncol Biol Phys; 2010 May 1;77(1):106-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Five patients had <1.5-cm(2) residual tumor, 4 had >or=1.5-cm(2) residual tumor, and the remainder had no residual tumor.
  • On univariate analysis, brainstem invasion, midline tumor location, younger age, and the absence of radiographic residual tumor were found to be predictors of PFS; the last two variables remained significant on multivariate analysis.
  • From 1990 to 2000 and from 2001 to 2007, the proportions of patients with no radiographic residual tumor were 77% and 94%, respectively.
  • Children with midline tumors exhibiting brainstem invasion are at increased risk.
  • With the increased incidence of PFS and the permanent morbidity in many patients, the risks and benefits of complete tumor removal in all patients need to be reexamined.
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Medulloblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Analysis of Variance. Ataxia / epidemiology. Ataxia / etiology. Child. Child, Preschool. Combined Modality Therapy / methods. Cranial Irradiation. Disease-Free Survival. Dysarthria / epidemiology. Dysarthria / etiology. Female. Follow-Up Studies. Humans. Incidence. Male. Muscle Hypotonia / epidemiology. Muscle Hypotonia / etiology. Mutism / epidemiology. Mutism / etiology. Neoplasm, Residual. Postoperative Complications / epidemiology. Radiotherapy Dosage. Retrospective Studies. Risk. Syndrome. Young Adult

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  • (PMID = 19695790.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Yamamoto T, Tsuji S: [Anti-Ma2-associated encephalitis and paraneoplastic limbic encephalitis]. Brain Nerve; 2010 Aug;62(8):838-51
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  • The corresponding antigen, Ma2 is selectively expressed intracellularly in neurons and tumors as is the case with other onconeuronal antigens targeted by classical antibodies.
  • These patients may have predominant cerebellar and/or brainstem dysfunctions due to more extensive involvement of subtentorial structures.
  • While it can cause severe neurological deficits or death in a substantial proportion of the patients, approximately one-third show neurological improvement and another 20 - 40% stabilize in response to treatment, including immunotherapy and/or tumor treatment.
  • Patients who have limited CNS involvement and testicular tumors with complete response to therapy are more likely to show neurological improvement.
  • In this respect, it is useful to highlight that anti-Ma2 encephalitis is almost always associated with testicular germ cell tumors in men younger than 50 years.
  • We experienced a 40-year-old patient with severe hypokinesis caused by anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes.
  • [MeSH-major] Antigens, Neoplasm / immunology. Autoantibodies. Limbic Encephalitis. Nerve Tissue Proteins / immunology
  • [MeSH-minor] Adult. Animals. Biomarkers / blood. Biomarkers / cerebrospinal fluid. Carcinoma, Non-Small-Cell Lung. Diagnosis, Differential. Female. Humans. Lung Neoplasms. Male. Middle Aged. Neoplasms, Germ Cell and Embryonal. Prognosis. Testicular Neoplasms

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  • (PMID = 20714032.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Autoantibodies; 0 / Biomarkers; 0 / Ma2 antigen; 0 / Nerve Tissue Proteins
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60. Alobid I, Gastón F, Morello A, Guilemany JM, Mullol J: Peripheral primitive neuroectodermal tumor of the cerebellopontine angle. Acta Otolaryngol; 2005 Apr;125(4):426-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral primitive neuroectodermal tumor of the cerebellopontine angle.
  • Peripheral primitive neuroectodermal tumors are highly malignant small cell neoplasms.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Ear, Inner / pathology. Ear, Inner / surgery. Female. Follow-Up Studies. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Retreatment

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  • (PMID = 15823816.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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61. Chernov MF, Skvortzova TY, Brodskaya ZL: Reduction of blood flow in the brain stem and cerebellum caused by petroclival tumors. Neurol Med Chir (Tokyo); 2005 Jan;45(1):31-5; discussion 36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reduction of blood flow in the brain stem and cerebellum caused by petroclival tumors.
  • Blood flow in the brain stem (BSBF) and cerebellum (CerBF) was investigated by positron emission tomography in 12 patients with petroclival tumors (study group) and 14 healthy volunteers (control group). (15)O-labeled water was used as the radioisotope tracer.
  • Five of 12 patients in the study group exhibited more than 20% reduction of CerBF ipsilateral to the tumor, whereas no such asymmetry was disclosed in any subject in the control group (p < 0.01).
  • Sex, age, and tumor histology had no statistically significant association with the level of BSBF.
  • No statistically significant association between BSBF and the type of postoperative course was found, whereas four of the five patients with more than 20% reduction of CerBF ipsilateral to the tumor had prominently increased cerebellar ataxia after removal of the neoplasm.
  • Preoperative investigation of the cerebral blood flow may be important for the prediction of outcome after surgical resection of petroclival tumors.
  • [MeSH-major] Brain Stem / blood supply. Cerebellum / blood supply. Cerebrovascular Circulation / physiology. Cranial Fossa, Posterior. Skull Base Neoplasms / physiopathology
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15699618.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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62. Saran F, Baumert BG, Creak AL, Warrington AP, Ashley S, Traish D, Brada M: Hypofractionated stereotactic radiotherapy in the management of recurrent or residual medulloblastoma/PNET. Pediatr Blood Cancer; 2008 Mar;50(3):554-60
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  • PURPOSE: To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy in the management of locally recurrent or residual central nervous system (CNS) primitive neuroectodermal tumors (PNETs).
  • [MeSH-major] Cerebellar Neoplasms / radiotherapy. Dose Fractionation. Medulloblastoma / radiotherapy. Neuroectodermal Tumors, Primitive / radiotherapy. Radiotherapy, Conformal / methods. Supratentorial Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Neoplasm Recurrence, Local / radiotherapy. Neoplasm, Residual. Palliative Care. Retrospective Studies. Stereotaxic Techniques

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17941071.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Tella OI, Stavale JN, Herculano MA, Paiva Neto MA, Onishi FJ, Guimarães Filho Fde A, Silva LR: [Size and proliferative index correlation in acoustic neuromas]. Arq Neuropsiquiatr; 2006 Mar;64(1):72-6
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  • Acoustic neuromas are the most common tumors in the cerebellopontine angle.
  • The molecular mechanisms involved in generation and growth of these tumors are not completely elucidated.
  • Many radiological, clinic and immunohistochemistry data were correlated to tumor growth.
  • The size of the tumors were positively correlationated with proliferative index.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Ki-67 Antigen / analysis. Neoplasm Proteins / analysis. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Age Distribution. Age Factors. Aged. Cell Proliferation. Cell Size. Female. Humans. Immunohistochemistry. Middle Aged. Mitotic Index. Neoplasm Invasiveness. Statistics, Nonparametric

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  • (PMID = 16622557.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins
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64. Tabori U, Sung L, Hukin J, Laperriere N, Crooks B, Carret AS, Silva M, Odame I, Mpofu C, Strother D, Wilson B, Samson Y, Bouffet E, Canadian Pediatric Brain Tumor Consortium: Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma. Int J Radiat Oncol Biol Phys; 2006 Feb 1;64(2):402-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / mortality. Medulloblastoma / mortality. Neoplasm Recurrence, Local / mortality
  • [MeSH-minor] Adolescent. Adult. Age Factors. Analysis of Variance. Child. Disease-Free Survival. Female. Humans. Male. Prognosis. Recurrence. Retrospective Studies. Sex Factors

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  • (PMID = 16198067.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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65. Brandes AA, Franceschi E, Tosoni A, Blatt V, Ermani M: Long-term results of a prospective study on the treatment of medulloblastoma in adults. Cancer; 2007 Nov 1;110(9):2035-41
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  • CONCLUSIONS: In adult patients with MB, long-term follow-up was essential for evaluating the real impact of treatments.
  • [MeSH-major] Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prospective Studies. Radiotherapy. Survival Rate. Time. Treatment Outcome

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  • (PMID = 17823910.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
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71. Pizem J, Cört A, Zadravec-Zaletel L, Popovic M: Survivin is a negative prognostic marker in medulloblastoma. Neuropathol Appl Neurobiol; 2005 Aug;31(4):422-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Cytoskeletal Proteins / metabolism. Female. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Male. Middle Aged. Prognosis. Survival Analysis. Trans-Activators / metabolism. Up-Regulation. beta Catenin

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  • (PMID = 16008826.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Trans-Activators; 0 / beta Catenin
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72. Spreafico F, Massimino M, Gandola L, Cefalo G, Mazza E, Landonio G, Pignoli E, Poggi G, Terenziani M, Pedrazzoli P, Siena S, Fossati-Bellani F: Survival of adults treated for medulloblastoma using paediatric protocols. Eur J Cancer; 2005 Jun;41(9):1304-10
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  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy
  • [MeSH-minor] Administration, Oral. Adolescent. Adult. Chemotherapy, Adjuvant / methods. Cranial Irradiation / methods. Disease-Free Survival. Humans. Infusions, Intravenous. Lomustine / administration & dosage. Lomustine / adverse effects. Methotrexate / administration & dosage. Methotrexate / adverse effects. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / mortality. Retrospective Studies. Treatment Outcome. Vincristine / administration & dosage. Vincristine / adverse effects

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  • (PMID = 15869875.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine; YL5FZ2Y5U1 / Methotrexate
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73. Roser F, Nakamura M, Dormiani M, Matthies C, Vorkapic P, Samii M: Meningiomas of the cerebellopontine angle with extension into the internal auditory canal. J Neurosurg; 2005 Jan;102(1):17-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The authors investigated cases of CPA tumors in which the meningioma was inserted in the dura mater in or at the ICA or infiltrated a cranial nerve.
  • Total tumor resection was achieved in 86.1%.
  • In 34 patients, opening of the IAC was required for total tumor removal; this procedure did not influence the patient functional outcome.
  • Functional preservation of the seventh and eighth cranial nerves in cases of tumor extension within the IAC was 86 and 77%, respectively, whereas in cases in which the IAC was involved it was only 60%.
  • In four of five patients in whom the tumor had its origin in the dura mater within the IAC, the seventh or eighth cranial nerve had to be sacrificed to achieve tumor removal because of the lesion's infiltrative behavior.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Ear, Inner / pathology. Meningeal Neoplasms / surgery. Meningioma / surgery
  • [MeSH-minor] Adult. Aged. Evoked Potentials, Auditory / physiology. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / physiopathology. Female. Humans. Intraoperative Care. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / radiography. Postoperative Care. Severity of Illness Index. Tomography, X-Ray Computed. Vestibulocochlear Nerve Diseases / diagnosis. Vestibulocochlear Nerve Diseases / epidemiology. Vestibulocochlear Nerve Diseases / physiopathology

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  • (PMID = 15658091.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Schild AM, Fricke J, Herkenrath P, Bolz H, Neugebauer A: [Neuro-ophthalmological and ophthalmological findings in Joubert syndrome]. Klin Monbl Augenheilkd; 2010 Oct;227(10):786-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Diseases. Coloboma. Polycystic Kidney Diseases
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adolescent. Amblyopia / diagnosis. Amblyopia / genetics. Antigens, Neoplasm / genetics. Blepharoptosis / diagnosis. Blepharoptosis / genetics. Brain Stem / abnormalities. Brain Stem / pathology. Cerebellum / abnormalities. Cerebellum / pathology. Child. Child, Preschool. Consanguinity. DNA Mutational Analysis. Electroretinography. Facial Paralysis / diagnosis. Facial Paralysis / genetics. Female. Fundus Oculi. Humans. Magnetic Resonance Imaging. Male. Membrane Proteins / genetics. Neoplasm Proteins / genetics. Nystagmus, Optokinetic / genetics. Ocular Motility Disorders / diagnosis. Ocular Motility Disorders / genetics. Refraction, Ocular. Retrospective Studies. Strabismus / diagnosis. Strabismus / genetics. Visual Acuity. Young Adult

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20963681.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antigens, Neoplasm; 0 / Cep290 protein, human; 0 / Membrane Proteins; 0 / NPHP1 protein, human; 0 / Neoplasm Proteins; Arima syndrome
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75. Armstrong CL, Vogel MW, Hawkes R: Development of Hsp25 expression compartments is not constrained by Purkinje cell defects in the Lurcher mouse mutant. J Comp Neurol; 2005 Oct 10;491(1):69-78
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  • Four transverse zones can be distinguished in the adult mouse cerebellar cortex based on differential expression of cell-specific antigens, termination patterns of mossy fiber afferents, and phenotypes of mouse mutants with cerebellar defects: the anterior zone (AZ), central zone (CZ), posterior zone (PZ), and nodular zone (NZ).
  • The Purkinje cell-specific antigen zebrin II is normally differentially expressed in all four zones of the adult cerebellum, but in the Lc/+ mutant is confined to the PZ and NZ, caudal to a transverse boundary in the dorsal aspect of lobule VIII.
  • Using immunohistochemistry we demonstrate that cerebellar maturation anterior to the CZ/PZ transverse boundary appears to be unaffected by the Lc allele, in that initial progression of Hsp25 expression in the Lc/+ cerebellum was similar to controls.
  • Double-labeling experiments with anti-Hsp25 and anti-calbindin suggest that characteristic banding patterns of Hsp25 in Lc/+ cerebellum develop and are preserved despite cell loss.
  • Thus, since simple temporal or spatial models cannot account for the zonal restriction seen during Lc/+ cerebellar development, the abnormality may be zebrin II-specific.
  • [MeSH-major] Cerebellum / growth & development. Heat-Shock Proteins / metabolism. Mice, Neurologic Mutants / metabolism. Neoplasm Proteins / metabolism. Nerve Tissue Proteins / metabolism. Purkinje Cells / metabolism

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16127699.001).
  • [ISSN] 0021-9967
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS34309
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calbindins; 0 / Heat-Shock Proteins; 0 / Hspb1 protein, mouse; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / S100 Calcium Binding Protein G; 0 / zebrin II
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76. Ramirez C, Delrieu O, Mineo JF, Paradot G, Allaoui M, Dubois F, Blond S: Intracranial dissemination of primary spinal cord anaplastic oligodendroglioma. Eur J Neurol; 2007 May;14(5):578-80
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  • We support a hypothesis whereby the anaplastic parts of tumors have spread along the spinal cord and brainstem via the cerebrospinal fluid pathways, a process that could be promoted by surgical manipulation, although the relative contribution of the two factors remains speculative.
  • [MeSH-major] Brain Neoplasms / secondary. Neoplasm Metastasis / physiopathology. Oligodendroglioma / secondary. Spinal Cord Neoplasms / pathology. Subarachnoid Space / physiopathology
  • [MeSH-minor] Adult. Cerebellar Neoplasms / secondary. Fatal Outcome. Humans. Hydrocephalus / etiology. Hydrocephalus / physiopathology. Hydrocephalus / therapy. Lateral Ventricles / pathology. Lateral Ventricles / physiopathology. Male. Neurosurgical Procedures / adverse effects

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  • (PMID = 17437621.001).
  • [ISSN] 1468-1331
  • [Journal-full-title] European journal of neurology
  • [ISO-abbreviation] Eur. J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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77. Biswas S, Burke A, Cherian S, Williams D, Nicholson J, Horan G, Jefferies S, Williams M, Earl HM, Burnet NG, Hatcher H: Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation? Pediatr Blood Cancer; 2009 Jul;52(7):796-803
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  • [Title] Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?
  • BACKGROUND: Supratentorial PNET (sPNET) are rare CNS tumors of embryonal origin arising in children and adults.
  • METHODS: Medical records were reviewed to gather demographic and clinical data about all embryonal CNS tumors in children and adults from 2001 to 2007.
  • Tumor pathology, clinical management and survival data were also assessed, particularly as regards those patients who received the Packer chemotherapy regimen for either sPNET or MB.
  • RESULTS: Eleven patients (five children and six adults) were identified with non-pineal sPNET, three children with pineal sPNET, and 19 patients (18 children and 1 adult) with MB.
  • There was no difference in overall survival (OS) rates between pediatric and adult sPNET.
  • We suggest that it is time to reconsider the use of this regimen in teenage and young adult non-pineal sPNET and to investigate the utility of alternative approaches.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / therapy. Cranial Irradiation. Medulloblastoma / therapy. Neuroectodermal Tumors, Primitive / therapy. Supratentorial Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Cisplatin / administration & dosage. Follow-Up Studies. Humans. Lomustine / administration & dosage. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome. Vincristine / administration & dosage. Young Adult

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19202566.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine; Q20Q21Q62J / Cisplatin
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78. Nigri F, Telles C, Acioly MA: Late obstruction of an endoscopic third ventriculostomy stoma by metastatic seeding of a recurrent medulloblastoma. J Neurosurg Pediatr; 2010 Jun;5(6):641-4
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  • Secondary obstruction of the stoma due to intraventricular tumor seeding is an extremely rare condition, with only one case described to date.
  • In such cases of late failure of the ETV stoma because of tumor obstruction, a second ETV can be safely performed and lead to adequate function of the stoma, even if limited by the aggressive nature of the disease.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Hydrocephalus / pathology. Hydrocephalus / surgery. Medulloblastoma / pathology. Medulloblastoma / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Seeding. Neuroendoscopy. Third Ventricle / pathology. Third Ventricle / surgery. Ventriculostomy
  • [MeSH-minor] Adolescent. Adult. Cerebrospinal Fluid / cytology. Disease Progression. Fatal Outcome. Follow-Up Studies. Fourth Ventricle / pathology. Fourth Ventricle / surgery. Humans. Magnetic Resonance Imaging. Male. Reoperation. Young Adult

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  • (PMID = 20515341.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. De la Cruz A, Teufert KB: Transcochlear approach to cerebellopontine angle and clivus lesions: indications, results, and complications. Otol Neurotol; 2009 Apr;30(3):373-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MAIN OUTCOME MEASURES: Indications, postoperative outcomes, and complications including tumor removal and facial nerve status (House-Brackmann grade).
  • The remainder included tumors associated with NF2, acoustic tumors, malignancies, and other lesions.
  • Complete removal was achieved in 92.5% of tumors.
  • CONCLUSION: The TC and TO approaches provide access to midline intradural lesions, intradural petroclival tumors, and cerebellopontine angle tumors and cholesteatomas arising anterior to the internal auditory canal, without using brain retractors.
  • Total tumor removal, including its base and blood supply, is possible.
  • With these approaches, recurrence israre when all tumor has been removed.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Cochlea / surgery. Cranial Fossa, Posterior / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Carotid Arteries / anatomy & histology. Child, Preschool. Data Interpretation, Statistical. Ear Canal / anatomy & histology. Ear Canal / surgery. Facial Nerve / physiology. Facial Nerve / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / surgery. Middle Aged. Neoplasm Recurrence, Local. Treatment Outcome. Young Adult

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  • (PMID = 19318889.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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80. Basu S, Rubello D: PET imaging in the management of tumors of testis and ovary: current thinking and future directions. Minerva Endocrinol; 2008 Sep;33(3):229-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PET imaging in the management of tumors of testis and ovary: current thinking and future directions.
  • Of these, the area where FDG-PET imaging has been examined the most in testicular tumors is the evaluation of postchemotherapy residual mass in both seminoma and nonseminomatous germ cell tumors (NSGCT) of the testis, a critical step in determining the subsequent management approach of these tumors that vary amongst various centers.
  • [MeSH-major] Ovarian Neoplasms / radionuclide imaging. Positron-Emission Tomography. Testicular Neoplasms / radionuclide imaging
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Clinical Trials as Topic. Combined Modality Therapy. Cost-Benefit Analysis. Female. Follow-Up Studies. Forecasting. Humans. Lymphoma, Non-Hodgkin / radionuclide imaging. Lymphoma, Non-Hodgkin / therapy. Male. Middle Aged. Neoplasm Staging / methods. Neoplasms, Germ Cell and Embryonal / radionuclide imaging. Neoplasms, Germ Cell and Embryonal / therapy. Paraneoplastic Cerebellar Degeneration / radionuclide imaging. Prognosis. Prospective Studies. Radiopharmaceuticals. Retrospective Studies

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  • (PMID = 18846028.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals
  • [Number-of-references] 83
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81. Kagawa N, Maruno M, Suzuki T, Hashiba T, Hashimoto N, Izumoto S, Yoshimine T: Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays. Brain Tumor Pathol; 2006 Apr;23(1):41-7
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  • [Title] Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays.
  • Medulloblastoma (MB) is the most frequent infratentorial malignant brain tumor in children.
  • In contrast, primitive neuroectodermal tumor (PNET) is defined as a supratentorial malignant tumor generated from the cerebral hemisphere.
  • These tumors have considerable histological overlap but have different clinical outcomes including overall survival period, recurrence rate, and chemosensitivity.
  • Genes that are frequently amplified in these both these tumors include MSH2, N-myc, AKT3, and EGFR.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Chromosome Aberrations. DNA, Neoplasm / genetics. Medulloblastoma / genetics. Medulloblastoma / pathology. Neuroectodermal Tumors, Primitive / genetics. Neuroectodermal Tumors, Primitive / pathology
  • [MeSH-minor] Biomarkers, Tumor. Cerebellum / pathology. Child. Child, Preschool. Female. Humans. In Situ Hybridization. Infant. Male. Microarray Analysis. Young Adult


82. Ali Y, Rahme R, Moussa R, Abadjian G, Menassa-Moussa L, Samaha E: Multifocal meningeal melanocytoma: a new pathological entity or the result of leptomeningeal seeding? J Neurosurg; 2009 Sep;111(3):488-91
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  • Meningeal melanocytoma is a rare benign CNS tumor derived from the leptomeningeal melanocytes.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellopontine Angle. Melanocytes / pathology. Melanoma / pathology. Meningeal Neoplasms / pathology. Neoplasm Seeding. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19361258.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Khalil EM: Treatment results of adults and children with medulloblastoma NCI, Cairo University experience. J Egypt Natl Canc Inst; 2008 Jun;20(2):175-86
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  • PATIENTS AND METHODS: Between 1997 and 2004, 67 patients were treated in the National cancer Institute- Cairo University; 51 pediatric patients with a median age of 7 years and 16 adult patients with a median age of 25 years.
  • According to the Chang staging system; 50%-35% , 37.5%-47% and 12.5%-18% had T2, T3 and T4 tumors of adults and pediatric patient's population respectively.
  • All patients underwent primary surgical resection; near total resection in 25% , Subtotal resection in 61% ; with tumor residual < 1.5cm(2) in 49% compared to 51% with > 1.5cm(2) residual tumor and 14% , had biopsy only.
  • The median interval between surgery and RT was 45 days and 38 days for the pediatric and adult groups respectively.
  • The median duration of RT was 54 days and 52 days for pediatric and adult patients respectively.
  • RESULTS: For the pediatric and adult patients, the 5- and 7-year overall and disease-free survival rates were 89% & 78% vs. 84% & 56% and 80% & 68% vs. 79% & 52% respectively.
  • Ninety percent (9/10) of the pediatric relapses were of the high risk group (8 received no chemotherapy) and took place within 2 years; similarly all adult relapses were of the high risk group; three relapses took place after 2 years.
  • For adult patients; only the risk category was a significant prognostic factor with 5-year disease-free survival rate of 100% vs. 40% for low and high risk respectively (p=0.03).
  • CONCLUSION: Survival rates of medulloblastoma pediatric patients were better than the adult ones.
  • Late relapses, lateral tumor location and shorter median follow up were noted in adult patients.
  • Advanced tumor stage, metastases at presentation, limited tumor resection were powerful prognostic factors among the pediatric patients.
  • In addition, high risk category was shown to be a prognostic factor for both pediatric and adult patients.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cerebellar Neoplasms / therapy. Cranial Irradiation. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20029474.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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84. Packer RJ, Gajjar A, Vezina G, Rorke-Adams L, Burger PC, Robertson PL, Bayer L, LaFond D, Donahue BR, Marymont MH, Muraszko K, Langston J, Sposto R: Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol; 2006 Sep 1;24(25):4202-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant / adverse effects. Child. Child, Preschool. Cisplatin / administration & dosage. Cyclophosphamide / administration & dosage. Disease-Free Survival. Female. Humans. Lomustine / administration & dosage. Male. Neoplasm Staging. Neoplasms, Second Primary / diagnosis. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant / adverse effects. Risk Factors. Survival Analysis. Vincristine / administration & dosage


85. Kaszper E, Hanzély Z, Szende B, Dabasi G, Garami M, Schuler D, Hauser P: [Examination of somatostatin receptor expression in recurrent childhood medulloblastomas]. Magy Onkol; 2008 Dec;52(4):351-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Medulloblastoma is the most common malignant pediatric central nervous system tumor.
  • Despite the adequate therapy the tumor often recurs.
  • The primary medulloblastoma expresses somatostatin receptor-2 (SSTR-2), but so far we had no experience about the receptor status in recurrent tumors.
  • All primary and recurrent tumors have been operated at the National Institute of Neurosurgery.
  • We examined the intensity and the percentage of SSTR-2-positive tumor cells in the primary and recurrent tumor samples.
  • All primary tumors were receptor-positive and SSTR-2 was also expressed in all recurrent medulloblastomas.
  • In our samples the percentage of SSTR-2-positive tumor cells was 30-90%.
  • As a conclusion, SSTR-2-positive recurrent tumors can be detected early by Octreoscan imaging, and the presence of SSTR-2 establishes the opportunity of applying somatostatin analogues (octreotide) in the treatment of recurrent childhood medulloblastoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cerebellar Neoplasms / chemistry. Medulloblastoma / chemistry. Neoplasm Recurrence, Local / chemistry. Receptors, Somatostatin / analysis
  • [MeSH-minor] Adolescent. Antineoplastic Agents, Hormonal / therapeutic use. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Indium Radioisotopes. Infant. Male. Octreotide / therapeutic use. Predictive Value of Tests. Somatostatin / analogs & derivatives. Tomography, Emission-Computed, Single-Photon / methods. Young Adult

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  • (PMID = 19068462.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers, Tumor; 0 / Indium Radioisotopes; 0 / Receptors, Somatostatin; 0 / somatostatin receptor 2; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide; RWM8CCW8GP / Octreotide
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86. Gururangan S, Krauser J, Watral MA, Driscoll T, Larrier N, Reardon DA, Rich JN, Quinn JA, Vredenburgh JJ, Desjardins A, McLendon RE, Fuchs H, Kurtzberg J, Friedman HS: Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. Neuro Oncol; 2008 Oct;10(5):745-51
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  • All patients in groups B and C have died of tumor, at a median of 35 months and 26 months from HDC and standard salvage therapy, respectively.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Salvage Therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Humans. Kaplan-Meier Estimate. Retrospective Studies

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  • (PMID = 18755919.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2666251
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87. Layadi F, Aniba K, Lmejjati M, Aït Elqadi A, Aït Benali S: [Giant osteoid osteoma of the posterior skull base. A case report and literature review]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):128-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones.
  • He presented with clinical sign of raised intracranial pressure, cerebellar symptoms and large left retro-auricular swelling.
  • [MeSH-major] Osteoma / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neurologic Examination. Neurosurgical Procedures

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  • (PMID = 16840973.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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88. Dunkel IJ, Gardner SL, Garvin JH Jr, Goldman S, Shi W, Finlay JL: High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma. Neuro Oncol; 2010 Mar;12(3):297-303
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  • Tumor recurred in 16 at a median of 8.5 months (range 2.3-58.5 months).
  • [MeSH-major] Cerebellar Neoplasms / therapy. Hematopoietic Stem Cell Transplantation. Medulloblastoma / therapy. Neoplasm Recurrence, Local / therapy. Salvage Therapy / methods
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Etoposide / administration & dosage. Female. Humans. Kaplan-Meier Estimate. Male. Quality of Life. Radiotherapy. Thiotepa / administration & dosage. Young Adult

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  • (PMID = 20167818.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 905Z5W3GKH / Thiotepa; BG3F62OND5 / Carboplatin
  • [Other-IDs] NLM/ PMC2940591
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89. Armstrong CL, Chung SH, Armstrong JN, Hochgeschwender U, Jeong YG, Hawkes R: A novel somatostatin-immunoreactive mossy fiber pathway associated with HSP25-immunoreactive purkinje cell stripes in the mouse cerebellum. J Comp Neurol; 2009 Dec 1;517(4):524-38
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  • [Title] A novel somatostatin-immunoreactive mossy fiber pathway associated with HSP25-immunoreactive purkinje cell stripes in the mouse cerebellum.
  • Somatostatin 28 immunoreactivity (Sst28-ir) identifies a specific subset of mossy fiber terminals in the adult mouse cerebellum.
  • In the cerebellum of the homozygous weaver mouse, in which a subpopulation of HSP25-ir Purkinje cells are located ectopically, the corresponding Sst28-ir mossy fiber projection is also ectopic, suggesting a role for a specific Purkinje cell subset in afferent pattern formation.
  • HSP25 itself does not appear to be critical for normal patterning, however: in the KJR mouse, which does not express cerebellar HSP25, Sst28 expression appears to be normal.
  • [MeSH-major] Cerebellum / cytology. Heat-Shock Proteins / metabolism. Neoplasm Proteins / metabolism. Nerve Fibers / metabolism. Purkinje Cells / metabolism. Somatostatin-28 / metabolism

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  • (PMID = 19795496.001).
  • [ISSN] 1096-9861
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Heat-Shock Proteins; 0 / Hspb1 protein, mouse; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Receptors, Somatostatin; 56-12-2 / gamma-Aminobutyric Acid; 75037-27-3 / Somatostatin-28; 9015-71-8 / Corticotropin-Releasing Hormone; EC 2.3.1.6 / Choline O-Acetyltransferase
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90. Bonneville F, Savatovsky J, Chiras J: Imaging of cerebellopontine angle lesions: an update. Part 2: intra-axial lesions, skull base lesions that may invade the CPA region, and non-enhancing extra-axial lesions. Eur Radiol; 2007 Nov;17(11):2908-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Algorithms. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging / methods. Female. Gadolinium / pharmacology. Humans. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Middle Aged. Neoplasm Invasiveness. Neuroma, Acoustic / diagnosis

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  • (PMID = 17569053.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
  • [Number-of-references] 75
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91. Massimino M, Gandola L, Spreafico F, Biassoni V, Luksch R, Collini P, Solero CN, Simonetti F, Pignoli E, Cefalo G, Poggi G, Modena P, Mariani L, Potepan P, Podda M, Casanova M, Pecori E, Acerno S, Ferrari A, Terenziani M, Meazza C, Polastri D, Ravagnani F, Fossati-Bellani F: No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma. Int J Radiat Oncol Biol Phys; 2009 Apr 1;73(5):1358-63
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  • RESULTS: Seventeen patients were treated: previous treatment included CSI of 19.5-36 Gy with posterior fossa/tumor boost and chemotherapy in 16 patients.
  • Twelve of 14 patients with assessable tumor had an objective response after reinduction; 2 experienced progression and were not given the myeloablative courses.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms. Medulloblastoma. Neoplasm Recurrence, Local. Salvage Therapy
  • [MeSH-minor] Adolescent. Carboplatin / administration & dosage. Carboplatin / adverse effects. Child. Child, Preschool. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy / methods. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Disease-Free Survival. Drug Administration Schedule. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Granulocyte Colony-Stimulating Factor / administration & dosage. Humans. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Radiotherapy Dosage. Remission Induction / methods. Thiotepa / administration & dosage. Thiotepa / adverse effects. Vincristine / administration & dosage. Vincristine / adverse effects. Young Adult

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  • (PMID = 19019566.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; 905Z5W3GKH / Thiotepa; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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92. Rousselot C, Francois P, Jan M, Bergemer AM: [Report of seven cases of clear-cell meningioma and a literature review]. Ann Pathol; 2010 Apr;30(2):73-82
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  • CCM occurred in various locations: medullary region (two), sphenoid wing (two), ponto-cerebellar angle (two), tentorium (one).
  • [MeSH-major] Biomarkers, Tumor / analysis. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Proteins / analysis
  • [MeSH-minor] Adult. Aged. Astrocytoma / diagnosis. Child, Preschool. Diagnostic Errors. Ependymoma / diagnosis. Female. Humans. Keratins / analysis. Ki-67 Antigen / analysis. Male. Middle Aged. Mucin-1 / analysis. Neurofibromatosis 2 / diagnosis. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / pathology. Receptors, Progesterone / analysis. Retrospective Studies. S100 Proteins / analysis. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20451062.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / Receptors, Progesterone; 0 / S100 Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 33
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93. Nordfors K, Haapasalo J, Korja M, Niemelä A, Laine J, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S, Haapasalo H: The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis. BMC Cancer; 2010;10:148
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Carbonic Anhydrase II / analysis. Carbonic Anhydrases / analysis. Cerebellar Neoplasms / enzymology. Medulloblastoma / enzymology. Neuroectodermal Tumors, Primitive / enzymology. Supratentorial Neoplasms / enzymology
  • [MeSH-minor] Adolescent. Adult. Aged. Apoptosis. Chi-Square Distribution. Child. Child, Preschool. Cytoplasm / enzymology. Endothelial Cells / enzymology. Female. Finland. Humans. Immunohistochemistry. Infant. Infant, Newborn. Kaplan-Meier Estimate. Male. Middle Aged. Odds Ratio. Proportional Hazards Models. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 20398423.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; EC 4.2.1.1 / carbonic anhydrase XII
  • [Other-IDs] NLM/ PMC2874782
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94. Perrault I, Delphin N, Hanein S, Gerber S, Dufier JL, Roche O, Defoort-Dhellemmes S, Dollfus H, Fazzi E, Munnich A, Kaplan J, Rozet JM: Spectrum of NPHP6/CEP290 mutations in Leber congenital amaurosis and delineation of the associated phenotype. Hum Mutat; 2007 Apr;28(4):416
The Lens. Cited by Patents in .

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  • All LCA patients shared an intronic mutation resulting in an aberrantly spliced transcript and low levels of wild-type transcript that was believed to explain the absence of cerebellar and renal involvement in these patients.
  • [MeSH-major] Antigens, Neoplasm / genetics. Frameshift Mutation. Neoplasm Proteins / genetics. Optic Atrophy, Hereditary, Leber / genetics
  • [MeSH-minor] Adult. Alleles. Child. Child, Preschool. Exons. Humans. Infant. Introns. Linkage Disequilibrium

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  • [Copyright] Copyright 2007 Wiley-Liss, Inc.
  • (PMID = 17345604.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cep290 protein, human; 0 / Neoplasm Proteins
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95. Nakamura Y, Kanemura Y, Yamada T, Sugita Y, Higaki K, Yamamoto M, Takahashi M, Yamasaki M: D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells. Mod Pathol; 2006 Jul;19(7):974-85
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

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  • [Title] D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells.
  • It has been used as a marker for lymphatic endothelium as well as mesothelioma and cerebellar hemangioblastoma.
  • In the developing cerebellum, positive D2-40 immunoreactivity was found in the external granular layer particularly of the outer portion and the Purkinje cell layer as well as meninges.
  • Some brain tumors such as anaplastic ependymoma, some medulloblastomas, glioblastoma, pineal germinoma, craniopharyngioma, choroid plexus papilloma, choroid plexus carcinoma, and meningioma showed positive immunoreactivity with D2-40.
  • Therefore, D2-40 antibody is considered a useful marker for research on developing brain and diagnosis of brain tumors, differentiation between choroid plexus carcinoma and metastatic carcinoma.
  • [MeSH-major] Antibodies, Monoclonal. Antigens, Neoplasm / analysis. Brain Neoplasms / immunology. Cerebellum / immunology. Telencephalon / immunology
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Cells, Cultured. Child, Preschool. Fetus / immunology. Gestational Age. Humans. Immunohistochemistry. Infant. Middle Aged. Neurons / cytology. Neurons / immunology. Prosencephalon / cytology. Stem Cells / cytology. Stem Cells / immunology

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  • (PMID = 16648867.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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96. Korshunov A, Benner A, Remke M, Lichter P, von Deimling A, Pfister S: Accumulation of genomic aberrations during clinical progression of medulloblastoma. Acta Neuropathol; 2008 Oct;116(4):383-90
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  • Medulloblastomas comprise the most frequent malignant brain tumor in childhood and one of the biggest challenges in pediatric oncology.
  • The current concept suggests that these tumors may undergo stepwise progression as it has been shown for other brain tumors.
  • In the present study, 28 pairs of medulloblastoma at primary diagnosis and at the time of recurrence, either occurring as local tumor regrowth or tumor dissemination, were histopathologically and molecularly analyzed.
  • Cytogenetic analysis included interphase fluorescence in situ hybridization for five genomic loci (MYC, MYCN, 17p, 17q, 6q) that have previously been identified as prognostic markers in primary tumors.
  • Of 16 tumors showing early recurrence (<4 years after first diagnosis), only one showed increased histological anaplasia in the secondary lesion (6%), and two acquired genomic lesions indicative for a more malignant phenotype (13%).
  • In contrast to this, of 12 tumors with a time to recurrence of 4 years or more, nine tumors (75%) showed a more malignant phenotype either reflected by increased anaplasia alone or by both increased anaplasia and acquirement of genomic aberrations known to be associated with inferior patient outcome.
  • These results suggest that early recurrence in medulloblastoma mainly occurs in tumors with a highly malignant genotype and phenotype per se, whereas late recurrence is often dependent on tumor evolution toward a more malignant biology.
  • Therefore, biopsy of recurrent tumors should be performed to assess the biologic properties of the relapsed tumor, especially when targeted therapy approaches are considered.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 17 / genetics. Chromosomes, Human, Pair 6 / genetics. Medulloblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. Proto-Oncogene Proteins c-myc / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Cytogenetic Analysis. Disease Progression. Female. Humans. Male. Neoplasm Recurrence, Local / genetics. Prognosis

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  • (PMID = 18704466.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYC protein, human; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Proto-Oncogene Proteins c-myc
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97. Haberler C, Slavc I, Czech T, Gelpi E, Heinzl H, Budka H, Urban C, Scarpatetti M, Ebetsberger-Dachs G, Schindler C, Jones N, Klein-Franke A, Maier H, Jauk B, Kiefer A, Hainfellner JA: Histopathological prognostic factors in medulloblastoma: high expression of survivin is related to unfavourable outcome. Eur J Cancer; 2006 Nov;42(17):2996-3003
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Inhibitor of Apoptosis Proteins. Male. Prognosis. Receptor, ErbB-2 / metabolism. Receptor, trkC / metabolism. Survival Analysis

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  • (PMID = 16996732.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptor, trkC
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98. Hanna SJ, Derham C, Van Hille P, Fenwick JD: Cerebellopontine angle meningioma resulting in middle-ear polyp. J Laryngol Otol; 2006 Sep;120(9):786-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cerebellar Neoplasms / radiography. Cerebellopontine Angle. Ear, Middle / radiography. Meningioma / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Tympanic Membrane / pathology. Tympanic Membrane / radiography

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  • (PMID = 16762094.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 15
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99. [Application of navigation system ExacTrac in radiation therapy of a female patient with disseminated pineoblastoma]. Zh Vopr Neirokhir Im N N Burdenko; 2010 Jan-Mar;(1):43-6
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  • We describe 1 illustrative case of a female patient with 2 metastases of pineoblastoma located in left cerebellar hemisphere and at the level of CVII vertebra.
  • [MeSH-major] Brain Neoplasms / surgery. Neuronavigation. Pineal Gland / surgery. Pinealoma / surgery. Radiosurgery
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Metastasis

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  • (PMID = 20429363.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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100. Iwai Y, Yamanaka K, Yamagata K, Yasui T: Surgery after radiosurgery for acoustic neuromas: surgical strategy and histological findings. Neurosurgery; 2007 Feb;60(2 Suppl 1):ONS75-82; discussion ONS82
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  • The operative indications were cerebellar ataxia and symptoms associated with increased intracranial pressure.
  • RESULTS: The tumors were subtotally removed (> or = 80%) in four patients and partially removed (< 80%) in the other two patients.
  • Histological features were typical of acoustic schwannoma, and some tumors were associated with foamy macrophages, myxoid degeneration, and necrosis attributed to radiation effects.
  • At follow-up, the residual tumor was decreased in five patients and increased in one patient with an expanding intratumoral hematoma.
  • CONCLUSION: Surgical resection after radiosurgery is indicated in the presence of such symptoms as cerebellar ataxia and increased intracranial pressure.
  • It must be carefully considered because of the natural regression of transient tumor swelling over time.
  • In patients with tumor enlargement several years after radiosurgery, the possibility of chronic intratumoral bleeding resulting from delayed radiation injury must be considered.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Humans. Magnetic Resonance Imaging. Middle Aged. Retrospective Studies. Treatment Failure

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  • (PMID = 17297369.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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