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1. Phi JH, Park SH, Paek SH, Kim SK, Lee YJ, Park CK, Cho BK, Lee DH, Wang KC: Expression of Sox2 in mature and immature teratomas of central nervous system. Mod Pathol; 2007 Jul;20(7):742-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Sox2 in mature and immature teratomas of central nervous system.
  • This study was undertaken to investigate the expression pattern of Sox2 in mature and immature teratomas of the central nervous system.
  • Sox2 immunohistochemistry was performed in 14 cases of central nervous system teratoma: five mature, five immature teratomas, and four mixed germ cell tumors with a prominent teratoma component.
  • Since Sox2 is strongly expressed in the primitive neuroepithelial tissues of central nervous system immature teratomas, it may be a useful biomarker for the diagnosis and quantitative grading of central nervous system immature teratomas.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. HMGB Proteins / biosynthesis. Teratoma / pathology. Transcription Factors / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Fluorescent Antibody Technique. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Infant. Male. Microscopy, Confocal. SOXB1 Transcription Factors

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  • (PMID = 17464316.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / HMGB Proteins; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / Transcription Factors
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2. Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S: Teratomas in central nervous system: a clinico-morphological study with review of literature. Neurol India; 2010 Nov-Dec;58(6):841-6

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  • [Title] Teratomas in central nervous system: a clinico-morphological study with review of literature.
  • AIMS: To study the demographic, clinico-morphological and follow-up data of central nervous system (CNS) teratomas.
  • MATERIALS AND METHODS: Cases diagnosed as mature or immature teratomas in the CNS over a 20-year period were included in the study.
  • Of these, 11 were mature cystic teratomas; and 1 case each, of teratoma with malignant transformation, terato-carcinoma and mixed germ cell tumor (immature teratoma with germinoma).
  • CONCLUSION: CNS teratomas are rare.
  • [MeSH-major] Central Nervous System Neoplasms / diagnosis. Central Nervous System Neoplasms / surgery. Teratoma / diagnosis. Teratoma / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgery. Young Adult

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  • (PMID = 21150046.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
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3. Daszkiewicz P, Roszkowski M, Przasnek S, Grajkowska W, Jurkiewicz E: Teratoma or enterogenous cyst? The histopathological and clinical dilemma in co-existing occult neural tube dysraphism. Folia Neuropathol; 2006;44(1):24-33
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  • [Title] Teratoma or enterogenous cyst? The histopathological and clinical dilemma in co-existing occult neural tube dysraphism.
  • BACKGROUND: Better understanding of embryology, histopathology and genetics of dysraphic conditions have lead to an expansion of this concept to entities with a similar microscopic appearance (e.g. enterogenous cysts, colloid cyst of the III-rd ventricle) or rated among neoplasms (e.g. mature teratoma), creating a certain conceptual confusion.
  • Currently the diagnosis of "teratoma" is being substituted by "enterogenous cyst" or "teratomatous cyst".
  • RESULTS: the study group included: 3 cases of type I enterogenous cyst, 1 case of type II cyst and 3 cases of type III cyst (in 2 cases a former diagnosis of "mature teratoma" has been revised).
  • Types II and III of enterogenous cyst were historically diagnosed as "adult teratoma".

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  • (PMID = 16565928.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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4. Pećina-Slaus N, Niku Eva-Martić T, Beros V, Tomas D: Genetic alterations of E-cadherin and beta-catenin in germinoma and teratoma: report of two central nervous system cases. Pathol Oncol Res; 2007;13(4):370-4
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  • [Title] Genetic alterations of E-cadherin and beta-catenin in germinoma and teratoma: report of two central nervous system cases.
  • The genetic basis as well as mechanisms of development of germ cell tumors of the CNS are still unexplained.
  • In the present article changes of Ecadherin (CDH1) and beta-catenin (CTNNB1) genes in two CNS germ cell tumors are reported.
  • A case of germinoma of the central nervous system and a case of spinal channel teratoma were tested for loss of heterozygosity (LOH) of E-cadherin gene by PCR amplification of tetranucleotide polymorphism (D16S752).
  • [MeSH-major] Cadherins / genetics. Central Nervous System Neoplasms / genetics. Germinoma / genetics. Teratoma / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Female. Humans. Loss of Heterozygosity. Male. Mutation. Pineal Gland / pathology. Pinealoma / genetics. Pinealoma / pathology. Spinal Cord Neoplasms / genetics. Spinal Cord Neoplasms / pathology

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  • (PMID = 18158575.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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5. Tüzün E, Zhou L, Baehring JM, Bannykh S, Rosenfeld MR, Dalmau J: Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma. Acta Neuropathol; 2009 Dec;118(6):737-43
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  • [Title] Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma.
  • No complement deposits were observed in any of the central nervous system regions examined.

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  • (PMID = 19680671.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R56 CA089054; United States / NCI NIH HHS / CA / R01 CA089054-02; United States / NCI NIH HHS / CA / CA107192-01; United States / NCI NIH HHS / CA / R01 CA107192-01; United States / NCI NIH HHS / CA / R01CA89054; United States / NCI NIH HHS / CA / R01 CA107192; United States / NCI NIH HHS / CA / R01CA107192; United States / NCI NIH HHS / CA / CA089054-02; United States / NCI NIH HHS / CA / R01 CA089054
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Receptors, N-Methyl-D-Aspartate
  • [Other-IDs] NLM/ NIHMS174149; NLM/ PMC2888642
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6. Okano H: Strategies toward CNS-regeneration using induced pluripotent stem cells. Genome Inform; 2009 Oct;23(1):217-20
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  • [Title] Strategies toward CNS-regeneration using induced pluripotent stem cells.
  • Secondary neurospheres (SNSs) generated from various mouse iPS cell showed their neural differentiation capacity and teratoma formation after transplantation into the brain of immunodeficient NOD/SCID mice.
  • Surprisingly, SNSs derived from c-Myc minus iPS cells generated without drug selection showed robust tumorigenesis, in spite of their potential to contribute adult chimeric mice without tumor formation.
  • [MeSH-major] Central Nervous System / physiology. Pluripotent Stem Cells / cytology. Regeneration

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  • (PMID = 20180278.001).
  • [ISSN] 0919-9454
  • [Journal-full-title] Genome informatics. International Conference on Genome Informatics
  • [ISO-abbreviation] Genome Inform
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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7. Samaras V, Stamatelli A, Samaras E, Stergiou I, Konstantopoulou P, Varsos V, Judkins AR, Biegel JA, Barbatis C: Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient. Clin Neuropathol; 2009 Jan-Feb;28(1):1-10
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  • [Title] Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient.
  • OBJECTIVE: Atypical teratoid/rhabdoid tumors are aggressive neoplasms of the central nervous system occurring mainly in the early childhood and rarely in adults.
  • To our knowledge, this is the eighth case of an ATRT reported in an adult patient having genetic confirmation and the first one in which the tumor is, partly, localized in the right temporal area of the brain.

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  • (PMID = 19216214.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA046274-17A2; United States / NCI NIH HHS / CA / R01 CA046274; United States / NCI NIH HHS / CA / CA 46274; United States / NCI NIH HHS / CA / R01 CA046274-17A2
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ NIHMS113796; NLM/ PMC2712356
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8. Bare JB, Abramowsky CR, Hayes LL, Shehata BM: Congenital immature teratoma of the central nervous system: three case reports with literature review. Fetal Pediatr Pathol; 2007 May-Jun;26(3):109-18
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  • [Title] Congenital immature teratoma of the central nervous system: three case reports with literature review.
  • Intracranial teratoma in the first case was diagnosed by MRI and in the second and third cases by ultrasound.
  • Congenital CNS teratoma should be considered in the differential diagnosis of fetuses diagnosed with macrocephaly or hydrocephaly.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Fetal Diseases / pathology. Teratoma / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Gestational Age. Humans. Male. Pregnancy. Prenatal Diagnosis. Review Literature as Topic

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  • (PMID = 17886021.001).
  • [ISSN] 1551-3815
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Umredkar A, Bal A, Vashista RK: Atypical teratoid/rhabdoid tumour of the central nervous system in adult: case report. Br J Neurosurg; 2010 Dec;24(6):699-704

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  • [Title] Atypical teratoid/rhabdoid tumour of the central nervous system in adult: case report.
  • Atypical teratoid/rhabdoid tumours (AT/RT) are aggressive neoplasms of the central nervous system occurring mainly in the paediatric population.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology
  • [MeSH-minor] Adult. Humans. Male. Treatment Outcome

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  • (PMID = 21070155.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Gyure KA: Newly defined central nervous system neoplasms. Am J Clin Pathol; 2005 Jun;123 Suppl:S3-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Newly defined central nervous system neoplasms.
  • In recent years, numerous new entities or variants of recognized central nervous system tumors have been described in the literature, and the morphologic spectrum of these neoplasms is delineated incompletely.
  • [MeSH-major] Central Nervous System Neoplasms / classification. Central Nervous System Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cerebellar Neoplasms / classification. Cerebellar Neoplasms / diagnosis. Child. Chordoma / classification. Chordoma / diagnosis. Diagnosis, Differential. Female. Ganglioglioma / classification. Ganglioglioma / diagnosis. Glioma / diagnosis. Glioma / pathology. Humans. Hypothalamic Neoplasms / classification. Hypothalamic Neoplasms / diagnosis. Male. Medulloblastoma / classification. Medulloblastoma / diagnosis. Prognosis. Rhabdoid Tumor / classification. Rhabdoid Tumor / diagnosis. Teratoma / classification. Teratoma / diagnosis. Third Ventricle / pathology

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  • (PMID = 16100866.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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11. Cheng YC, Lirng JF, Chang FC, Guo WY, Teng MM, Chang CY, Wong TT, Ho DM: Neuroradiological findings in atypical teratoid/rhabdoid tumor of the central nervous system. Acta Radiol; 2005 Feb;46(1):89-96
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  • [Title] Neuroradiological findings in atypical teratoid/rhabdoid tumor of the central nervous system.
  • PURPOSE: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) findings of atypical teratoid tumor/rhabdoid tumor (AT/RT) of the central nervous system (CNS).
  • MATERIAL AND METHODS: Twenty cases of CNS AT/RT have been found over the past 23 years in our hospital; these involving 11 boys and 9 girls whose mean age at diagnosis was 5.5 years.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Central Nervous System Neoplasms / radiography. Rhabdoid Tumor / pathology. Rhabdoid Tumor / radiography. Teratoma / pathology. Teratoma / radiography
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Prognosis. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 15841745.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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12. Tonomura Y, Kataoka H, Hara Y, Takamure M, Naba I, Kitauti T, Saito K, Ueno S: Clinical analysis of paraneoplastic encephalitis associated with ovarian teratoma. J Neurooncol; 2007 Sep;84(3):287-92
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  • [Title] Clinical analysis of paraneoplastic encephalitis associated with ovarian teratoma.
  • BACKGROUND: Recently, paraneoplastic encephalitis associated with ovarian teratoma has been described and related to an autoantibody.
  • METHODS: We describe four patients with ovarian teratoma-associated encephalitis (OTE) and compared their clinical pictures with those of 17 previously reported patients with OTE.
  • RESULTS: Clinically, OTE was characterized by the development of acute prominent psychiatric symptoms (20 of 21 patients), seizures (15 of 21 patients), and central hypoventilation (13 of 21 patients).
  • CONCLUSIONS: OTE presents with cardiac conduction problems and hypersalivation in addition to psychiatric symptoms, seizures, and central hypoventilation.
  • [MeSH-major] Ovarian Neoplasms / complications. Paraneoplastic Syndromes, Nervous System / etiology. Paraneoplastic Syndromes, Nervous System / physiopathology. Teratoma / complications
  • [MeSH-minor] Adolescent. Adult. Arrhythmias, Cardiac / etiology. Brain / pathology. Female. Humans. Hypoventilation / etiology. Magnetic Resonance Imaging. Mental Disorders / etiology. Seizures / etiology. Sialorrhea / etiology

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  • (PMID = 17431543.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Wang Z, Fan QH, Yu MN, Zhang WM: [Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system]. Zhonghua Bing Li Xue Za Zhi; 2006 Aug;35(8):458-61
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  • [Title] [Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system].
  • OBJECTIVE: To study the clinicopathologic features and differential diagnosis of atypical teratoid/rhabdoid tumor (AT/RT) occurring in the central nervous system.
  • CONCLUSIONS: AT/RT is a highly malignant tumor occurring in the central nervous system.
  • It needs to be distinguished from a number of central nervous system tumors, including medulloblastoma, primitive neuroectodermal tumor, germ cell neoplasm and rhabdoid meningioma.
  • [MeSH-major] Brain Neoplasms / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology
  • [MeSH-minor] Actins / analysis. Adult. Antigens, CD / analysis. Cell Adhesion Molecules / analysis. Child, Preschool. Desmin / analysis. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Keratins / analysis. Male. Mucin-1 / analysis. Muscle, Smooth / chemistry. Neurofilament Proteins / analysis. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 17069697.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 0 / Neurofilament Proteins; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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14. Ngan KW, Jung SM, Lee LY, Chuang WY, Yeh CJ, Hsieh YY: Immunohistochemical expression of OCT4 in primary central nervous system germ cell tumours. J Clin Neurosci; 2008 Feb;15(2):149-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of OCT4 in primary central nervous system germ cell tumours.
  • The aim of this study was to evaluate the role of OCT4 expression in the diagnosis of primary central nervous system (CNS) pure and mixed GCT.
  • Seventeen formalin-fixed, paraffin-embedded tissues of primary CNS GCT were immunohistochemically studied.
  • The 12 pure GCT samples comprised germinoma (5), yolk sac tumour (3), mature teratoma (2), and immature teratoma (2).
  • The five cases of mixed GCT contained various components as follows: yolk sac tumour (4), embryonal carcinoma (3), mature teratoma (1), germinoma (2), polyembryoma (1) and immature teratoma (1).
  • There was no corresponding staining in pure GCT of yolk sac tumour, mature teratoma, or immature teratoma except in a primitive neuroectodermal component, or in mixed GCT containing components of yolk sac tumour, mature teratoma or immature teratoma.
  • In conclusion, we found that OCT4 immunostaining is a useful diagnostic tool to assist in the identification of primary CNS embryonal carcinoma and germinoma.
  • In CNS mixed GCT, OCT4 expression can be detected provided that the components include embryonal carcinoma and/or germinoma.
  • [MeSH-major] Central Nervous System Neoplasms / metabolism. Neoplasms, Germ Cell and Embryonal / metabolism. Octamer Transcription Factor-3 / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Male

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  • (PMID = 17997317.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human
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15. Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T: Nestin expression in central nervous system germ cell tumors. Neurosurg Rev; 2008 Apr;31(2):173-6; discussion 176-7

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  • [Title] Nestin expression in central nervous system germ cell tumors.
  • Central nervous system (CNS) germ cell tumors constitute a unique class of rare tumors that mainly affect children and adolescents.
  • Nestin is an intermediate filament protein expressed in undifferentiated cells during CNS development and in CNS tumors and is used as a marker of immature elements of tumors, including brain tumor stem cells.
  • In this study, we examined for the first time nestin expression in 19 CNS germ cell tumors (nine pure germinomas, five germinomas with syncytiotrophoblastic giant cells, one yolk sac tumor, one choriocarcinoma, one embryonal carcinoma, and two mature teratomas).
  • These findings suggest that the detection of nestin expression could be useful in the management of CNS germ cell tumors, as an auxiliary predictor of dissemination and/or progression.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Biomarkers, Tumor / genetics. Central Nervous System Neoplasms / genetics. Intermediate Filament Proteins / biosynthesis. Intermediate Filament Proteins / genetics. Neoplasms, Germ Cell and Embryonal / genetics. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Choriocarcinoma / genetics. Choriocarcinoma / metabolism. Choriocarcinoma / pathology. Endodermal Sinus Tumor / genetics. Endodermal Sinus Tumor / metabolism. Endodermal Sinus Tumor / pathology. Female. Germinoma / genetics. Germinoma / metabolism. Germinoma / pathology. Giant Cell Tumors / genetics. Giant Cell Tumors / metabolism. Giant Cell Tumors / pathology. Humans. Hypopituitarism / etiology. Immunoenzyme Techniques. Magnetic Resonance Imaging. Male. Nestin. Teratoma / genetics. Teratoma / metabolism. Teratoma / pathology. Vision Disorders / etiology

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  • (PMID = 18092184.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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16. Behdad A, Perry A: Central nervous system primitive neuroectodermal tumors: a clinicopathologic and genetic study of 33 cases. Brain Pathol; 2010 Mar;20(2):441-50
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  • [Title] Central nervous system primitive neuroectodermal tumors: a clinicopathologic and genetic study of 33 cases.
  • Central nervous system (CNS) primitive neuroectodermal tumors (PNETs) include supratentorial, brain stem, and spinal cord tumors with medulloblastoma-like histopathology.
  • After re-diagnosis of three infantile cases as atypical teratoid/rhabdoid tumor (AT/RT), 33 remaining CNS PNETs were retrieved for clinicopathologic and fluorescence in situ hybridization studies.
  • We conclude that in CNS PNET: (i) routine application of INI1 immunohistochemistry helps rule out AT/RT, particularly in infants;.
  • (iii) involvement of CNS parenchyma by Ewing sarcoma/peripheral PNET is rare enough that EWS gene testing is not necessary unless significant dural involvement is present; and (iv) both anaplastic/large cell features and polysomies of 2 and 8 are associated with more aggressive clinical behavior.
  • [MeSH-minor] Adolescent. Adult. Aneuploidy. Child. Child, Preschool. Chromosomes, Human, Pair 2. Chromosomes, Human, Pair 22. Chromosomes, Human, Pair 8. Female. Humans. Infant. Male. Middle Aged. Nuclear Proteins / genetics. Oncogene Proteins / genetics. RNA-Binding Protein EWS / genetics. Rhabdoid Tumor / diagnosis. Rhabdoid Tumor / genetics. Rhabdoid Tumor / pathology. Teratoma / diagnosis. Teratoma / genetics. Teratoma / pathology. Young Adult

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  • (PMID = 19725831.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / RNA-Binding Protein EWS
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17. Idowu MO, Rosenblum MK, Wei XJ, Edgar MA, Soslow RA: Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. Am J Surg Pathol; 2008 May;32(5):710-8
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  • [Title] Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein.
  • We reviewed the morphologic and immunohistochemical features of 5 extra-axial ependymomas occurring in adults, 1 arising in an infantile sacrococcygeal teratoma, and a control group of 10 central nervous system (CNS) ependymomas in adults.
  • The adult extra-axial cases demonstrated more architectural variability than the CNS cases.
  • We observed that both the CNS and adult extra-axial ependymomas expressed GFAP diffusely, whereas only 9 stage III, high-grade ovarian serous papillary carcinomas stained with GFAP (2 strongly and diffusely and 7 exhibiting focally weak expression).
  • There were significant immunophenotypic differences between adult extra-axial and CNS ependymomas, with extra-axial cases preferentially expressing 34betaE12 (60% vs. 0%), CK18 (100% vs. 20%), CAM 5.2 (60% vs. 10%), CK7 (80% vs. 10%), ER (100% vs. 10%), and PR (80% vs. 20%).
  • CNS ependymomas more frequently expressed CD99 (100% vs. 20%).
  • The following stains were not differentially expressed: epithelial membrane antigen (expressed in 2 of 15 cases, including both extra-axial and CNS ependymomas), synaptophysin (1/15), chromogranin (0/15), WT1 (8/15), AE1:3 (10/15), and CK20 (0/15).
  • The ependymal elements of the sacrococcygeal tumor failed to express 34betaE12, CK18, CAM 5.2, and CK7, like most CNS ependymomas.
  • The morphologic and immunophenotypic differences between extra-axial and CNS ependymomas suggest that they derive from distinct precursors and/or differentiate along distinct pathways.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Central Nervous System Neoplasms / metabolism. Ependymoma / metabolism. Glial Fibrillary Acidic Protein / metabolism. Ovarian Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Immunoenzyme Techniques. Infant. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging

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  • (PMID = 18360284.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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18. Vibert-Guigue C, Gonzales M, Gouellet N, Zirah C, Milliez J, Carbonne B: Vaginal delivery using cranioclasia following prenatal diagnosis of a giant fetal intracranial teratoma. Fetal Diagn Ther; 2008;23(3):222-7
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  • [Title] Vaginal delivery using cranioclasia following prenatal diagnosis of a giant fetal intracranial teratoma.
  • Intracranial teratoma, although a rare disease, is nonetheless the most common of the congenital tumors of the central nervous system in the neonatal period.
  • The prognosis for fetal forms of teratoma is very grim.
  • We report here the case of an immature teratoma identified at 26 weeks' gestation and discuss its obstetric consequences, in particular, the technical procedures for a medically-indicated termination of pregnancy in view of the massive increase in head circumference associated with this tumor.
  • [MeSH-major] Abortion, Induced / methods. Brain Neoplasms / congenital. Brain Neoplasms / ultrasonography. Teratoma / congenital. Teratoma / ultrasonography
  • [MeSH-minor] Adult. Breech Presentation. Female. Fetal Death. Gestational Age. Humans. Magnetic Resonance Imaging. Polyhydramnios / ultrasonography. Pregnancy. Ultrasonography, Prenatal

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18417982.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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19. Okano H: [Regeneration of the central nervous system using iPS cell-technologies]. Rinsho Shinkeigaku; 2009 Nov;49(11):825-6
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  • [Title] [Regeneration of the central nervous system using iPS cell-technologies].
  • We found that secondary neurospheres (SNSs) generated from various mouse iPS cell showed their neural differentiation capacity and teratoma formation after transplantation into the brain of immunodeficient NOD/SCID mice.
  • Surprisingly, SNSs derived from c-Myc minus iPS cells generated without drug selection showed robust tumorigenesis, in spite of their potential to contribute adult chimeric mice without tumor formation.

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  • (PMID = 20030221.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 3
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20. Iizuka T: [Clinical features and pathogenesis of anti-NMDA receptor encephalitis]. Rinsho Shinkeigaku; 2008 Nov;48(11):920-2
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  • The antibodies are usually detected in CSF/serum of young women with ovarian teratoma, who typically developed schizophrenia-like psychiatric symptoms, usually preceded by viral infection-like illness.
  • Most cases developed seizures, followed by unresponsive/catatonic state, decreased level of consciousness, central hypoventilation, orofacial-limb dyskinesias, and autonomic symptoms.
  • The prodromal "viral-like" disorder by itself or in combination with a teratoma sets off the autoimmune response.
  • [MeSH-major] Autoantibodies. Encephalitis. Paraneoplastic Syndromes, Nervous System. Receptors, N-Methyl-D-Aspartate / immunology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Dyskinesias / etiology. Female. Humans. Japan / epidemiology. Male. Middle Aged. Ovarian Neoplasms. Schizophrenia / etiology. Sleep Apnea, Central / etiology. Teratoma. Young Adult

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  • (PMID = 19198118.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Receptors, N-Methyl-D-Aspartate
  • [Number-of-references] 10
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21. Le Foll J, Pelletier A: [Psychiatric symptoms of a paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis: A case report]. Encephale; 2010 Apr;36(2):166-71
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  • INTRODUCTION: We describe the case of a young woman affected by a benign ovarian teratoma with paraneoplastic encephalitis.
  • BACKGROUND: Paraneoplastic encephalitis usually begins with a prodromal phase, followed first by prominent psychiatric symptoms or, less frequently, short-term memory loss, seizure, catatonia-like symptoms, dyskynesias and, secondly, by autonomic instability and central hypoventilation requiring intensive care.
  • It has been shown that patients suffering from paraneoplastic encephalitis associated with ovarian teratoma display antibodies for anti-N-methyl-D-aspartate (NMDA) receptors in CSF or plasma (more specifically for the NR1 subunit of the NRl/NR2 heteromers required to form a functional NMDA receptor).
  • The NR1/NR2B heteromers are preferentially expressed in the adult hippocampus/forebrain, which are brain regions involved in the pathogenesis of various psychiatric, psychotic in particular, symptoms.
  • [MeSH-major] Autoantibodies / cerebrospinal fluid. Ovarian Neoplasms / psychology. Paraneoplastic Syndromes, Nervous System / diagnosis. Paraneoplastic Syndromes, Nervous System / psychology. Receptors, N-Methyl-D-Aspartate / immunology. Teratoma / diagnosis. Teratoma / psychology
  • [MeSH-minor] Bipolar Disorder / diagnosis. Bipolar Disorder / immunology. Bipolar Disorder / psychology. Brain / pathology. Diagnostic Errors. Female. Humans. Magnetic Resonance Imaging. Neurologic Examination. Patient Care Team. Tomography, X-Ray Computed. Young Adult

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  • [Copyright] 2009 L'Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.
  • (PMID = 20434635.001).
  • [ISSN] 0013-7006
  • [Journal-full-title] L'Encéphale
  • [ISO-abbreviation] Encephale
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Receptors, N-Methyl-D-Aspartate
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22. Harms D, Zahn S, Göbel U, Schneider DT: Pathology and molecular biology of teratomas in childhood and adolescence. Klin Padiatr; 2006 Nov-Dec;218(6):296-302
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  • The Kiel Pediatric Tumor Registry includes 541 teratoma specimens, and among these, the most frequent tumor sites (in descending order) are: the sacrococcygeal region (33.8 %), the ovaries (31.2 %) and the testes (10.5 %).
  • Rare localizations include the mediastinum, the retroperitoneum, the head and neck region as well as the central nervous system.
  • According to the grading system (Gonzalez-Crussi, 1982), mature teratomas (G0) are more frequent (54.5 %) than immature teratomas (G1-G3, 45.5 %).
  • [MeSH-major] Ovarian Neoplasms. Registries. Teratoma. Testicular Neoplasms
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Chromosome Aberrations. Chromosome Deletion. Cytogenetic Analysis. Endodermal Sinus Tumor / epidemiology. Endodermal Sinus Tumor / pathology. Female. Germany / epidemiology. Heterozygote. Humans. Incidence. Infant. Infant, Newborn. Male. Ovary / pathology. Puberty. Testis / pathology

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  • (PMID = 17080330.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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23. Hirayama Y, Kubota M, Kakita A, Kawasaki T, Hasegawa G, Tanaka S, Ohtaki M, Yamazaki S, Okuyama N, Yagi M, Naito M: Sacral parasite with histopathological features of an unequally conjoined twin. Pediatr Surg Int; 2007 Jul;23(7):715-20

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  • Even though a large proportion of the central nervous system tissue showed immature and dysplastic features, there were no evidences suggesting the presence of neoplasm.
  • We therefore believe that the present case should be considered a sacral parasite, rather than a sacrococcygeal teratoma.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Infant, Newborn. Teratoma / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 17351782.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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24. Khatua S, Dhall G, O'Neil S, Jubran R, Villablanca JG, Marachelian A, Nastia A, Lavey R, Olch AJ, Gonzalez I, Gilles F, Nelson M, Panigrahy A, McComb G, Krieger M, Fan J, Sposto R, Finlay JL: Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation. Pediatr Blood Cancer; 2010 Jul 15;55(1):42-6
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  • [Title] Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation.
  • BACKGROUND: The purpose of this study was to evaluate a reduced irradiation dose strategy for newly diagnosed primary central nervous system (CNS) germinomas.
  • METHODS: Twenty patients with histologically diagnosed localized pure germinoma (n = 19) or germinoma with a mature teratoma component (n = 1) received four cycles of carboplatin and etoposide at 3-week intervals.
  • CONCLUSION: Chemotherapy followed by reduced dose whole ventricular and local boost irradiation appears to be effective in patients with localized pure CNS germinoma with evidence of preservation of neurocognitive function.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / therapy. Central Nervous System Neoplasms / therapy. Germinoma / therapy. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Adolescent. Adult. Carboplatin / adverse effects. Carboplatin / therapeutic use. Child. Child, Preschool. Chorionic Gonadotropin, beta Subunit, Human / blood. Combined Modality Therapy. Dose-Response Relationship, Radiation. Etoposide / adverse effects. Etoposide / therapeutic use. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Retrospective Studies. Young Adult. alpha-Fetoproteins / analysis

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  • (PMID = 20222020.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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25. Yoshikata R, Yamamoto T, Kobayashi M, Ota H: Immunohistochemical characteristics of mature ovarian cystic teratomas in patients with postoperative recurrence. Int J Gynecol Pathol; 2006 Jan;25(1):95-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Because a mature teratoma could recur, we studied the clinical, pathological, and immunohistochemical characteristics of mature ovarian cystic teratomas of 121 patients who underwent surgeries between 1994 and 2002.
  • The recurrence group was generally younger (mean, 22.9 +/- 1.26 vs. 32.8 +/- 1.15 years; p < 0.05), had higher tridermal components, and had greater central nervous system (CNS) component expression rate (9 vs. 48%, p < 0.05) compared with the non-recurrence group.
  • [MeSH-major] Neoplasm Recurrence, Local. Ovarian Neoplasms / chemistry. Teratoma / chemistry
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Female. Fluorescent Antibody Technique, Indirect. Glial Fibrillary Acidic Protein / analysis. Humans. Intermediate Filament Proteins / analysis. Nerve Tissue Proteins / analysis. Nestin. Neuroglia / pathology. Neurons / pathology. Synaptophysin / analysis

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  • (PMID = 16306792.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Synaptophysin
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26. Chen YW, Wong TT, Ho DM, Huang PI, Chang KP, Shiau CY, Yen SH: Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience). Int J Radiat Oncol Biol Phys; 2006 Mar 15;64(4):1038-43
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  • [Title] Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience).
  • PURPOSE: To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT).
  • METHODS AND MATERIALS: Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Rhabdoid Tumor / radiotherapy. Teratoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Cranial Irradiation / methods. Disease-Free Survival. Female. Humans. Male. Multivariate Analysis. Radiotherapy Dosage. Retrospective Studies. Survival Analysis

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  • [CommentIn] Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1273; author reply 1273-4 [16798419.001]
  • (PMID = 16406394.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Cebesoy FB, Balat O, Dikensoy E, Ugur MG, Kutlar I, Kalayci H: Role of dietary habits on fetal anomaly development: review of 315 consecutive fetal anomaly cases. Clin Exp Obstet Gynecol; 2008;35(4):264-6
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  • RESULTS: Total fetal anomaly incidence was found to be 4.17%, neural tube defects 1.37%, renal anomalies 0.54%, non-immune fetal hydrops 0.46%, cystic hygroma 0.39%, central nervous system anomalies 0.36%, chromosomal anomalies 0.17%, gastrointestinal system anomalies 0.147%, sacrococcygeal teratoma 0.12%, cardiac anomalies 0.09%, and respiratory system anomalies 0.049%.
  • [MeSH-minor] Adolescent. Adult. Cohort Studies. Female. Humans. Incidence. Middle Aged. Prenatal Exposure Delayed Effects. Retrospective Studies. Risk Factors. Turkey / epidemiology. Young Adult

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  • (PMID = 19205440.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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28. Kao CL, Chiou SH, Ho DM, Chen YJ, Liu RS, Lo CW, Tsai FT, Lin CH, Ku HH, Yu SM, Wong TT: Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor. Am J Clin Pathol; 2005 Feb;123(2):297-304
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  • Osteopontin, a cancer metastasis-associated gene, is specifically up-regulated in central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT), but its biological behavior in the progression of CNS AT/RT has never been studied.
  • [MeSH-major] Brain Neoplasms / metabolism. Rhabdoid Tumor / metabolism. Sialoglycoproteins. Teratoma / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Enzyme-Linked Immunosorbent Assay. Humans. Infant. Infant, Newborn. Medulloblastoma / metabolism. Medulloblastoma / mortality. Medulloblastoma / pathology. Neoplasm Recurrence, Local. Osteopontin. Survival Rate

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  • (PMID = 15842057.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin
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29. Iczkowski KA, Butler SL, Shanks JH, Hossain D, Schall A, Meiers I, Zhou M, Torkko KC, Kim SJ, MacLennan GT: Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. Hum Pathol; 2008 Feb;39(2):275-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 93 germ cell tumors (41 seminoma, 22 embryonal carcinoma, 18 teratoma, and 12 yolk sac tumor) were obtained from the central nervous system (30), mediastinum (23), retroperitoneum/abdomen (31), and other locations (9).
  • Epithelial membrane antigen discriminated teratoma from other nonseminomas with a sensitivity of 1 but reacted occasionally in embryonal carcinoma (3/15) and yolk sac tumor (2/7).
  • [MeSH-minor] Adolescent. Adult. Antibodies, Monoclonal / analysis. Antibodies, Monoclonal, Murine-Derived. Female. Fluorescent Antibody Technique, Indirect. Humans. Male. Octamer Transcription Factor-3 / analysis. Sensitivity and Specificity. Transcription Factor AP-2 / analysis

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  • [ErratumIn] Hum Pathol. 2013 Dec;44(12):2873
  • (PMID = 18045648.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / Transcription Factor AP-2; 0 / monoclonal antibody D2-40
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