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1. Liu Q, Liu R, Kashyap MV, Agarwal R, Shi X, Wang CC, Yang SH: Brainstem glioma progression in juvenile and adult rats. J Neurosurg; 2008 Nov;109(5):849-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brainstem glioma progression in juvenile and adult rats.
  • OBJECT: Brainstem gliomas are common in children and have the worst prognosis of any brain tumor in this age group.
  • On the other hand, brainstem gliomas are rare in adults, and the authors of some clinical studies have suggested that this lesion behaves differently in adults than in children.
  • In the present study, the authors test an orthotopic C6 brainstem glioma model in juvenile and adult rats, and investigate the biological behavior of this lesion in the 2 age groups.
  • METHODS: The C6 glioma cells were stereotactically implanted into the pons of juvenile or adult male rats.
  • Tumor proliferation and the number of apoptotic cells in brainstem gliomas of young and adult rats were determined by immunohistochemical staining with Ki 67 and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate-mediated nick-end labeling assay.
  • RESULTS: Striking differences in the onset of neurological signs, duration of symptoms, survival time, tumor growth pattern, tumor proliferation, and number of apoptotic cells were found between the gliomas in the 2 groups of rats.
  • The lesions were relatively focal in adult rats but more diffuse in young rats.
  • Furthermore, brainstem gliomas in adult rats were less proliferative and had more apoptotic cells than those in young rats.
  • CONCLUSIONS: The authors found that the C6 brainstem glioma model in young and adult rats closely imitates the course of brainstem glioma in humans both in neurological findings and histopathological characteristics.
  • Their findings also suggest that the different growth pattern and invasiveness of these lesions in children compared with that in adults could be due to different cellular environments in the 2 age groups, and warrants further investigation into the difference in the host response to brainstem gliomas in children and adults.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Glioma / pathology
  • [MeSH-minor] Age Factors. Animals. Apoptosis. Cell Line, Tumor. Cell Proliferation. Disease Models, Animal. Disease Progression. Kaplan-Meier Estimate. Male. Neoplasm Transplantation / pathology. Rats. Rats, Sprague-Dawley

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  • (PMID = 18976074.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS054651; United States / NINDS NIH HHS / NS / R01 NS054651-01A2; United States / NINDS NIH HHS / NS / R01 NS054687; United States / NINDS NIH HHS / NS / R01 NS054687-01A2
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS75237; NLM/ PMC2693119
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2. Broniscer A, Laningham FH, Kocak M, Krasin MJ, Fouladi M, Merchant TE, Kun LE, Boyett JM, Gajjar A: Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma. Cancer; 2006 Mar 15;106(6):1364-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma.
  • BACKGROUND: Children with diffuse brainstem glioma (BSG) commonly undergo novel therapies because their outcome is poor with radiation therapy (RT).
  • METHODS: All available brain imaging studies and medical records of 48 consecutive patients with newly diagnosed BSG treated at the study institution over a 10-year interval (1992-2002) were reviewed.
  • At the time of last follow-up, all patients had died of tumor progression.
  • The uniform occurrence of IH among patients treated with various chemotherapeutic regimens and its association with necrotic areas suggests that tumor biology plays a significant role in this event.
  • [MeSH-major] Brain Stem Neoplasms / diagnosis. Cerebral Hemorrhage / diagnosis. Glioma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Cranial Irradiation. Female. Humans. Magnetic Resonance Imaging. Male. Necrosis. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 16463390.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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3. Mehta VS, Chandra PS, Singh PK, Garg A, Rath GK: Surgical considerations for 'intrinsic' brainstem gliomas: proposal of a modification in classification. Neurol India; 2009 May-Jun;57(3):274-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical considerations for 'intrinsic' brainstem gliomas: proposal of a modification in classification.
  • BACKGROUND: Brainstem gliomas are highly heterogeneous tumors both in their clinical manifestation and in their pathology.
  • Despite significant advances in the surgery for brainstem gliomas many aspects of this pathology are still unclear.
  • OBJECTIVE: To evaluate the clinical, radiological and surgical outcome of 40 focal 'intrinsic' brainstem gliomas and propose a surgical strategy-oriented classification.
  • Our criteria included patients with (1) well-defined gadolinium enhancing tumor;.
  • RESULTS: The 'intrinsic' brainstem tumors were classified into three types: Expanding, diffuse infiltrative and pure ventral varieties.
  • Only patients with expanding variety of brainstem gliomas were subjected to surgery, mean age 19.2 years (range 4-55 years) and male to female ration mean: 3:2).
  • The tumor location included pons (n=19), midbrain (n=13) and medulla (n=8).
  • CONCLUSION: The surgical management of intrinsic brainstem tumors presents a surgical challenge; radical excision yielded a good outcome in the majority of cases.
  • The authors propose a classification system for 'intrinsic' brainstem tumors for defining surgical strategy.
  • [MeSH-major] Brain Stem Neoplasms / classification. Brain Stem Neoplasms / surgery. Glioma / classification. Glioma / surgery. Neurosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Child, Preschool. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Survival Analysis. Treatment Outcome. Young Adult

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  • [CommentIn] Neurol India. 2009 May-Jun;57(3):231-2 [19587459.001]
  • (PMID = 19587467.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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4. Joshi BH, Puri RA, Leland P, Varricchio F, Gupta G, Kocak M, Gilbertson RJ, Puri RK, US Pediatric Brain Tumor Consortium: Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma. Neuro Oncol; 2008 Jun;10(3):265-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma.
  • Human malignant glioma cell lines and adult brain tumors overexpress high levels of interleukin-13 receptor alpha2 chain (IL-13Ralpha2).
  • Because the IL-13Ralpha2 chain is an important target for cancer therapy and prognosis for patients with brainstem glioma (BSG) remains dismal, we investigated the expression of this receptor in specimens of diffusely infiltrative pediatric BSG relative to normal brain tissue.
  • Twenty-eight BSG specimens and 15 normal brain specimens were investigated for IL-13Ralpha2 protein expression by immunohistochemical analysis (IHC) using two different antibodies in two different laboratories.
  • By Q-dot IHC or a standard IHC assay, 17 of 28 (61%) tumor specimens showed modest to strong staining for IL-13Ralpha2, while 15 normal brain tissue samples showed weak expression for IL-13Ralpha2 protein.
  • High-level IL-13Ralpha2 RNA expression was detected in tumor samples by Q-dot ISH, but only weak RNA expression was observed in normal brain.
  • IL-13Ralpha2 protein and mRNA are expressed to significantly higher levels in BSG than in normal brain tissue.

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  • (PMID = 18430795.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA081457; United States / NCI NIH HHS / CA / U01 CA81457
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Interleukin-13 Receptor alpha2 Subunit; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2563049
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5. Pollack IF, Jakacki RI, Blaney SM, Hancock ML, Kieran MW, Phillips P, Kun LE, Friedman H, Packer R, Banerjee A, Geyer JR, Goldman S, Poussaint TY, Krasin MJ, Wang Y, Hayes M, Murgo A, Weiner S, Boyett JM: Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report. Neuro Oncol; 2007 Apr;9(2):145-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report.
  • This study estimated the maximum tolerated dose (MTD) of imatinib with irradiation in children with newly diagnosed brainstem gliomas, and those with recurrent malignant intracranial gliomas, stratified according to use of enzyme-inducing anticonvulsant drugs (EIACDs).
  • In the brainstem glioma stratum, imatinib was initially administered twice daily during irradiation, but because of possible association with intratumoral hemorrhage (ITH) was subsequently started two weeks after irradiation.
  • Twenty-four evaluable patients received therapy before the amendment, and three of six with a brainstem tumor experienced dose-limiting toxicity (DLT): one had asymptomatic ITH, one had grade 4 neutropenia and, one had renal insufficiency.
  • After protocol amendment, 3 of 16 patients with brainstem glioma and 2 of 11 patients with recurrent glioma who were not receiving EIACDs experienced ITH DLTs, with three patients being symptomatic.
  • The recommended phase II dose for brainstem gliomas was 265 mg/m(2).
  • Three of 27 patients with brainstem gliomas with imaging before and after irradiation, prior to receiving imatinib, had new hemorrhage, excluding their receiving imatinib.
  • In summary, recommended phase II imatinib doses were determined for children with newly diagnosed brainstem glioma and recurrent high-grade glioma who were not receiving EIACDs.
  • Imatinib may increase the risk of ITH, although the incidence of spontaneous hemorrhages in brainstem glioma is sufficiently high that this should be considered in studies of agents in which hemorrhage is a concern.

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  • (PMID = 17293590.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000188; United States / NCI NIH HHS / CA / U01 CA081457; United States / NCRR NIH HHS / RR / M01 RR00188-37; United States / NCI NIH HHS / CA / U01 CA81457
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
  • [Other-IDs] NLM/ PMC1871662
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6. Riina HA, Knopman J, Greenfield JP, Fralin S, Gobin YP, Tsiouris AJ, Souweidane MM, Boockvar JA: Balloon-assisted superselective intra-arterial cerebral infusion of bevacizumab for malignant brainstem glioma. A technical note. Interv Neuroradiol; 2010 Mar;16(1):71-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Balloon-assisted superselective intra-arterial cerebral infusion of bevacizumab for malignant brainstem glioma. A technical note.
  • Malignant brainstem gliomas (BSG) are rare tumors in adults, associated with a grim prognosis and limited treatment options.
  • Intravenous (IV) administration of bevacizumab (Avastin, Genentech Pharmaceuticals) has been shown to be active in the treatment of some enhancing malignant brainstem gliomas.
  • In addition, the percentage of IV drug that reaches the tumor site is restricted by the blood brain barrier (BBB).Weill Cornell Brain Tumor Center, Department of Neurosurgery, Weill Cornell Medical College of Cornell University: New York, NY, USA.
  • This technical report describes our protocol in performing superselective intra-arterial cerebral infusion (SIACI) of bevacizumab using endovascular balloon-assistance in the top of the basilar artery in a patient with a recurrent malignant brainstem glioma.
  • This method of drug delivery may have important implications in the treatment of both adult and pediatric brainstem gliomas.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Brain Stem Neoplasms / diagnostic imaging. Brain Stem Neoplasms / drug therapy. Catheterization / methods. Glioma / diagnostic imaging. Glioma / drug therapy. Infusions, Intra-Arterial / methods
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Humanized. Antineoplastic Agents / administration & dosage. Bevacizumab. Humans. Male. Radiography. Treatment Outcome

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  • (PMID = 20377982.001).
  • [ISSN] 1591-0199
  • [Journal-full-title] Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
  • [ISO-abbreviation] Interv Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 2S9ZZM9Q9V / Bevacizumab
  • [Other-IDs] NLM/ PMC3277958
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7. Gururangan S, Chi SN, Young Poussaint T, Onar-Thomas A, Gilbertson RJ, Vajapeyam S, Friedman HS, Packer RJ, Rood BN, Boyett JM, Kun LE: Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. J Clin Oncol; 2010 Jun 20;28(18):3069-75
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  • [Title] Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study.
  • PURPOSE: A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in children with recurrent malignant glioma (MG) and intrinsic brainstem glioma (BSG).
  • CONCLUSION: BVZ plus CPT-11 was well-tolerated but had minimal efficacy in children with recurrent malignant glioma and brainstem glioma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adolescent. Adult. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Bevacizumab. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Child. Diffusion Magnetic Resonance Imaging. Humans. Phosphorylation. Survival Rate. Treatment Outcome. Vascular Endothelial Growth Factor Receptor-2 / metabolism. Young Adult

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  • (PMID = 20479404.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000188; United States / NCI NIH HHS / CA / U01 CA081457; United States / NCRR NIH HHS / RR / M01RR00188; United States / NCI NIH HHS / CA / U01CA81457
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0H43101T0J / irinotecan; 2S9ZZM9Q9V / Bevacizumab; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; XT3Z54Z28A / Camptothecin
  • [Other-IDs] NLM/ PMC2903337
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8. Yoshimura J, Nishiyama K, Fukuda M, Watanabe M, Igarashi H, Fujii Y: Adult cerebellopontine angle medulloblastoma originating in the pons mimicking focal brainstem tumor. J Neuroimaging; 2009 Oct;19(4):385-7
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  • [Title] Adult cerebellopontine angle medulloblastoma originating in the pons mimicking focal brainstem tumor.
  • We herein report a rare case of cerebellopontine angle (CPA) medulloblastoma originating in the brainstem that demonstrated a very unusual clinical presentation and radiological appearances.
  • MR spectroscopic imaging is considered to be quite useful for the management of this rare type of brainstem tumor.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Cerebellopontine Angle / pathology. Infratentorial Neoplasms / pathology. Medulloblastoma / pathology. Pons / pathology
  • [MeSH-minor] Adult. Aspartic Acid / analogs & derivatives. Aspartic Acid / metabolism. Choline / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Functional Laterality. Humans. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy

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  • (PMID = 19021841.001).
  • [ISSN] 1552-6569
  • [Journal-full-title] Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • [ISO-abbreviation] J Neuroimaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; N91BDP6H0X / Choline
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9. Dong Y, Wei SH, Pi YL, Yan RM: [Ocular manifestations of brainstem tumor]. Zhonghua Yan Ke Za Zhi; 2009 Nov;45(11):999-1003
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  • [Title] [Ocular manifestations of brainstem tumor].
  • OBJECTIVE: To investigate the ocular manifestations of brainstem tumors and to avoid misdiagnosis and missed diagnosis.
  • The clinical data of 57 brainstem tumor in-patients were collected from 1993 to 2007.
  • RESULTS: The present series included 51 cases of brainstem germinoma, 4 cases of cavernous hemangioma, 1 case of hemangioblastoma and 1 case of metastatic tumor.
  • In 51 cases of brainstem germinoma, there were 37 males and 14 females.
  • The high incident ages of brainstem germinoma were 10 - 35 years.
  • CONCLUSIONS: Ocular manifestations occur frequently in brainstem tumor.
  • Nuclear ophthalmoplegia, nystagmus and other neuro-ophthalmic signs provide helpful clues for the diagnosis of brainstem tumor.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Eye Diseases / pathology
  • [MeSH-minor] Adolescent. Adult. Brain Stem / pathology. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20137418.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Laigle-Donadey F, Doz F, Delattre JY: Brainstem gliomas in children and adults. Curr Opin Oncol; 2008 Nov;20(6):662-7
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  • [Title] Brainstem gliomas in children and adults.
  • PURPOSE OF REVIEW: The purpose of this review is to determine if recent advances in diagnostic and treatment modalities result in improvement in the pattern of care of brainstem gliomas.
  • RECENT FINDINGS: New MRI techniques may contribute to differential diagnosis and aid neurosurgeons in removing resectable brainstem tumors.
  • However, biopsy remains indicated in many contrast enhancing brainstem masses in adults because of the great variety of differential diagnosis.
  • SUMMARY: Diffuse brainstem glioma is the most common subtype of brainstem tumor and remains a devastating malignancy in children.
  • Given the lack of efficacy of conventional drugs, a better understanding of the biology of this tumor is the key to more targeted therapy.
  • [MeSH-major] Brain Neoplasms / drug therapy. Brain Stem / pathology. Glioma / drug therapy
  • [MeSH-minor] Adult. Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents / therapeutic use. Biopsy. Child. Drug Delivery Systems. Humans. Magnetic Resonance Imaging / methods. Medical Oncology / methods. Neoplasm Metastasis. Neurofibromatosis 1 / drug therapy. Neurofibromatosis 1 / pathology. Signal Transduction

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  • (PMID = 18841048.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents
  • [Number-of-references] 57
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11. Colletti V: Auditory outcomes in tumor vs. nontumor patients fitted with auditory brainstem implants. Adv Otorhinolaryngol; 2006;64:167-85
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  • [Title] Auditory outcomes in tumor vs. nontumor patients fitted with auditory brainstem implants.
  • Auditory brainstem implants (ABIs) are currently indicated for patients older than 12 years with neurofibromatosis type 2 (NF2) who had bilateral schwannoma removed.
  • Over the last 10 years, we have extended the indications for ABIs to nontumor children and adult patients with cochlear or cochlear nerve injuries or malfunctions who would not benefit from a cochlear implant.
  • In the present chapter we report our recent findings in adult ABI patients and compare the psychophysical and speech perception outcomes in tumor with those in nontumor patients.
  • We demonstrate that the ABI can stimulate the central auditory system in a way that gives the ability of open set speech understanding, and can thus be indicated in nontumor adult patients who are not candidates for a cochlear implant.
  • At 1 year after implantations nontumor adults scored from 12 to 100% in open set speech perception tests (average 59%), and tumor (NF2) patients scored from 5 to 30% (average of 11%).
  • To investigate the cause of the differences in performance between tumor and nontumor ABI recipients, a series of psychophysical tests were done consecutively in 39 adult patients with implants (25 nontumor and 14 tumor patients) from May 1999 to April 2004 and with a follow-up of at least 1 year.
  • (1) The ABIs allow most tumor and nontumor patients to experience improved communication as well as awareness of environmental sounds. (2) Nontumor patients had better hearing outcomes than tumor patients when the variation in the auditory benefit with the ABI in relation to the patient's underlying pathological conditions were taken into consideration. (3) A significant number of nontumor patients are able understand speech at a level comparable to that of the most successful cochlear implant users including conversational telephone use. (4) The ABI represents the tool for hearing rehabilitation in patients with profound hearing loss who cannot be fitted with cochlear implants.
  • [MeSH-major] Auditory Brain Stem Implants. Ear Neoplasms / surgery. Hearing Loss / surgery. Neurilemmoma / surgery. Neurofibromatosis 2 / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Case-Control Studies. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Postoperative Care. Speech Perception / physiology. Treatment Outcome

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  • (PMID = 16891842.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 38
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12. Ueoka DI, Nogueira J, Campos JC, Maranhão Filho P, Ferman S, Lima MA: Brainstem gliomas--retrospective analysis of 86 patients. J Neurol Sci; 2009 Jun 15;281(1-2):20-3

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  • [Title] Brainstem gliomas--retrospective analysis of 86 patients.
  • Brainstem gliomas constitute 10% of brain tumors in children and less than 2% in adults.
  • Since therapeutic options are limited and brainstem gliomas are associated with a high morbidity and mortality, we sought to analyze the prognostic factors associated with a better outcome.
  • We reviewed the records of 86 patients with brainstem gliomas treated between 1996 and 2006.
  • Of 86 patients with brainstem gliomas, 55.8% were females.
  • A short duration of symptoms, which may imply a more aggressive tumor, was associated with a worst prognosis in patients with brainstem gliomas.
  • [MeSH-major] Brain Stem Neoplasms / diagnosis. Glioma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Brain Stem / pathology. Child. Child, Preschool. Disease Progression. Female. Humans. Infant. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19345380.001).
  • [ISSN] 1878-5883
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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13. Hussain A, Brown PD, Stafford SL, Pollock BE: Stereotactic radiosurgery for brainstem metastases: Survival, tumor control, and patient outcomes. Int J Radiat Oncol Biol Phys; 2007 Feb 1;67(2):521-4
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  • [Title] Stereotactic radiosurgery for brainstem metastases: Survival, tumor control, and patient outcomes.
  • PURPOSE: Patients with brainstem metastases have limited treatment options.
  • In this study, we reviewed outcomes after stereotactic radiosurgery (SRS) in the management of patients with brainstem metastases.
  • METHODS AND MATERIALS: Records were reviewed of 22 consecutive patients presenting with brainstem metastases who underwent SRS.
  • Three patients (14%) also underwent whole-brain radiation therapy (WBRT).
  • The median tumor volume was 0.9 mL (range, 0.1-3.3 mL); the median tumor margin dose was 16 Gy (range, 14-23 Gy).
  • Although local tumor control was achieved in all patients with imaging follow-up (n = 19), 5 patients died from development and progression of new brain metastases.
  • CONCLUSIONS: Radiosurgery is safe and provides a high local tumor control rate for patients with small brainstem metastases.
  • [MeSH-major] Brain Stem Neoplasms / radiotherapy. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Breast Neoplasms. Female. Humans. Kidney Neoplasms. Lung Neoplasms. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17097830.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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14. Ruivo J, Antunes JL: Maffucci syndrome associated with a pituitary adenoma and a probable brainstem tumor. J Neurosurg; 2009 Feb;110(2):363-8
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  • [Title] Maffucci syndrome associated with a pituitary adenoma and a probable brainstem tumor.
  • Malignancies are a common feature of Maffucci syndrome, with chondrosarcomas being the most common tumor type.
  • The authors present the first case of Maffucci syndrome associated with a pituitary adenoma and a probable brainstem glioma and review the literature concerning intracranial tumors related to this disease.
  • Neuroimaging revealed a pituitary macroadenoma and a suspected brainstem tumor.
  • [MeSH-major] Brain Stem Neoplasms / complications. Enchondromatosis / complications. Magnetic Resonance Imaging. Neoplasms, Multiple Primary / complications. Pituitary Neoplasms / complications. Pons
  • [MeSH-minor] Adult. Decompression, Surgical. Female. Humans. Nerve Compression Syndromes / diagnosis. Nerve Compression Syndromes / surgery. Optic Chiasm / pathology. Optic Nerve Diseases / diagnosis. Optic Nerve Diseases / surgery. Vision Disorders / diagnosis. Vision Disorders / etiology. Vision Disorders / surgery

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  • (PMID = 18976063.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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15. Fuentes S, Delsanti C, Metellus P, Peragut JC, Grisoli F, Regis J: Brainstem metastases: management using gamma knife radiosurgery. Neurosurgery; 2006 Jan;58(1):37-42; discussion 37-42
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  • [Title] Brainstem metastases: management using gamma knife radiosurgery.
  • OBJECTIVE: Brainstem metastasis is an uncommon complication of systemic cancer, generally considered to have a highly unfavorable prognosis.
  • The purpose of this study is to evaluate our experience using Gamma Knife radiosurgery (GKRS) for the management of brainstem metastasis.
  • METHODS: Between July 1992 and March 2001, we treated 28 patients with brainstem metastasis using GKRS.
  • The most frequent primary tumor site was the lung (13 cases) followed by the melanoma in four cases, the kidney in two, and other locations in six.
  • Only six patients underwent fractionated whole-brain radiation therapy.
  • Local tumor control was achieved in 92% of patients.
  • Death was related to the progression of the brainstem lesion in two cases.
  • CONCLUSION: The results of this small series demonstrate that GKRS can be a valuable modality for safe and effective management of brain stem metastasis.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Brain Stem. Radiosurgery
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Follow-Up Studies. Humans. Kidney Neoplasms / secondary. Lung Neoplasms / secondary. Male. Medulla Oblongata. Melanoma / secondary. Mesencephalon. Middle Aged. Pons. Survival Analysis. Treatment Outcome

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  • (PMID = 16385327.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Amato VG, Assietti R, Morosi M, Arienta C: Acute brainstem dissection of syringomyelia associated with cervical intramedullary neurinoma. Neurosurg Rev; 2005 Apr;28(2):163-7
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  • [Title] Acute brainstem dissection of syringomyelia associated with cervical intramedullary neurinoma.
  • The acute onset of syringomyelia is most likely attributable to an acute increase in cerebrospinal fluid and epidural venous pressure that results in impulsive fluid movement and, ultimately, in the rupture of the syrinx and dissection into the spinal cord or brainstem.
  • (1) how can a small tumor produce a large syrinx?
  • On the basis of current pathogenetic concepts, the authors concluded that tumor-related syringomyelia might be caused by an association of mechanisms, both from within (obstruction of perivascular spaces; increase in extracellular fluid viscosity due to the tumor itself; intramedullary pressure gradients among different cord levels and between the cord and the subarachnoid space) and from without (the cerebrospinal fluid entering the tissue).
  • All these factors may be amplified, as in the reported case, by a tumor located dorsally at the cervical level.
  • [MeSH-major] Brain Stem. Neurilemmoma / complications. Spinal Cord Neoplasms / complications. Syringomyelia / etiology
  • [MeSH-minor] Acute Disease. Adult. Cervical Vertebrae. Female. Humans. Rupture, Spontaneous / etiology. Rupture, Spontaneous / physiopathology. Rupture, Spontaneous / surgery

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  • (PMID = 15789252.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 41
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17. Miki T, Nakajima N, Akimoto J, Wada J, Haraoka J: Neuroendoscopic trans-third ventricle approach for lesions of the ventral brainstem surface. Minim Invasive Neurosurg; 2008 Dec;51(6):313-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendoscopic trans-third ventricle approach for lesions of the ventral brainstem surface.
  • Due to the establishment in recent years of neuroendoscopic third ventriculostomy (ETV), it has become possible during ETV to observe the ventral brainstem surface--particularly the prepontine cistern--in a minimally invasive manner via the third ventricular base with a neuroendoscope.
  • As an adaptation of that technique in this study, we investigated a neuroendoscopic trans-third ventricle approach (ETTVA), which accesses lesions of the ventral brainstem surface with a neuroendoscope inserted via the stoma of the third ventricular floor.
  • Surgical operations performed by ETTVA included 3 cases of tumor resection, 2 cases of tumor biopsy, and 1 case of cyst puncture and aspiration.
  • [MeSH-major] Astrocytoma / surgery. Brain Stem Neoplasms / surgery. Chordoma / surgery. Minimally Invasive Surgical Procedures / methods. Neuroendoscopy / methods. Third Ventricle / surgery. Ventriculostomy / methods
  • [MeSH-minor] Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19061139.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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18. Kesari S, Kim RS, Markos V, Drappatz J, Wen PY, Pruitt AA: Prognostic factors in adult brainstem gliomas: a multicenter, retrospective analysis of 101 cases. J Neurooncol; 2008 Jun;88(2):175-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors in adult brainstem gliomas: a multicenter, retrospective analysis of 101 cases.
  • BACKGROUND: Adult brainstem gliomas (BSG) are uncommon and poorly understood with respect to prognostic factors.
  • Out of 24 candidate prognosis factors, we selected seven covariates for proportional hazards model by Lasso procedure: age of diagnosis, ethnicity, need for corticosteroids, tumor grade, dysphagia, tumor location, and karnofsky performance status (KPS).
  • Multivariate analysis showed that four covariates significantly increased hazard for survival: ethnicity, tumor location, age of diagnosis, and tumor grade.
  • [MeSH-major] Brain Stem Neoplasms / diagnosis. Glioma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Algorithms. Disease Progression. Female. Follow-Up Studies. Health Surveys. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Multivariate Analysis. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 18365144.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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19. Stark AM, Maslehaty H, Hugo HH, Mahvash M, Mehdorn HM: Glioblastoma of the cerebellum and brainstem. J Clin Neurosci; 2010 Oct;17(10):1248-51
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  • [Title] Glioblastoma of the cerebellum and brainstem.
  • Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor.
  • Because of its rarity and the non-specific radiological features of iGB, it can easily be misdiagnosed as a brain metastasis, ependymoma or even as a benign lesion such as vestibular schwannoma or meningioma.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Stem / pathology. Cerebellum / pathology. Glioblastoma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20619657.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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20. Nakaya K, Niranjan A, Kondziolka D, Kano H, Khan AA, Nettel B, Koebbe C, Pirris S, Flickinger JC, Lunsford LD: Gamma knife radiosurgery for benign tumors with symptoms from brainstem compression. Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):988-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for benign tumors with symptoms from brainstem compression.
  • PURPOSE: This study evaluated the role of radiosurgery in the management of symptomatic patients with brainstem compression from benign basal tumors.
  • METHODS AND MATERIALS: Over a 17-year, period 246 patients (202 vestibular schwannomas and 44 meningiomas) with brainstem compression from benign skull-base tumors were managed with Gamma Knife radiosurgery.
  • Median tumor volumes were 3.9 cm(3) (range, 0.8-39.0 mL) and 6.6 mL (range, 1.6-25.1 mL) for vestibular schwannomas and meningiomas, respectively.
  • Patients were categorized into four groups on the basis of the tumor-brainstem relationship on neuroimaging.
  • RESULTS: Preservation of function was stratified according to grade of brainstem compression.
  • We analyzed the effect of radiosurgery on symptoms of brainstem compression.
  • The tumor control rate was 100 % for meningioma and 97% for vestibular schwannomas (although 5% required an additional procedure such as a ventriculoperitoneal shunt).
  • Balance improved significantly in patients who had less tumor compression (p = 0.0357) after radiosurgery.
  • CONCLUSION: Radiosurgery is a minimally invasive option for patients with benign basal tumors that indent or distort the brainstem.
  • A high tumor growth control rate and satisfactory rate of neurological preservation and symptom control can be obtained with radiosurgery.
  • [MeSH-major] Brain Stem. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Constriction, Pathologic / surgery. Female. Humans. Male. Middle Aged. Statistics, Nonparametric. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20381265.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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21. Koyfman SA, Tendulkar RD, Chao ST, Vogelbaum MA, Barnett GH, Angelov L, Weil RJ, Neyman G, Reddy CA, Suh JH: Stereotactic radiosurgery for single brainstem metastases: the cleveland clinic experience. Int J Radiat Oncol Biol Phys; 2010 Oct 1;78(2):409-14
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  • [Title] Stereotactic radiosurgery for single brainstem metastases: the cleveland clinic experience.
  • PURPOSE: To assess the imaging and clinical outcomes of patients with single brainstem metastases treated with stereotactic radiosurgery (SRS).
  • MATERIALS AND METHODS: We retrospectively reviewed the data from patients with single brainstem metastases treated with SRS.
  • RESULTS: Between 1997 and 2007, 43 patients with single brainstem metastases were treated with SRS.
  • The 1-year actuarial rate of local control, distant brain control, and overall survival was 85%, 38.3%, and 31.5%, respectively.
  • On multivariate analysis, greater performance status (hazard ratio [HR], 0.95, p = .004), score index for radiosurgery (HR, 0.7; p = .004), graded prognostic assessment score (HR, 0.48; p = .003), and smaller tumor volume (HR, 1.23, p = .002) were associated with improved survival.
  • CONCLUSION: The results of our study have shown that SRS is a safe and effective local therapy for patients with brainstem metastases.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Multivariate Analysis. Ohio. Proportional Hazards Models. Radiotherapy Planning, Computer-Assisted / methods. Retrospective Studies. Salvage Therapy / methods. Survival Analysis. Tumor Burden

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20133072.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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22. Ree A, Jain R, Rock J, Rosenblum M, Patel SC: Direct infiltration of brainstem glioma along the cranial nerves. J Neuroimaging; 2005 Apr;15(2):197-9
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  • [Title] Direct infiltration of brainstem glioma along the cranial nerves.
  • The authors describe a case of a low-grade brainstem glioma extending along the cranial nerves without any evidence of leptomeningeal spread.
  • The tumor extended directly along the VII-VIIIth cranial nerve complex and also along the trigeminal nerve, which is quite an unusual characteristic of the glial tumors.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Cranial Nerve Neoplasms / pathology. Glioma / pathology
  • [MeSH-minor] Adult. Facial Nerve Diseases / pathology. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Trigeminal Nerve Diseases / pathology. Vestibulocochlear Nerve Diseases / pathology

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  • (PMID = 15746234.001).
  • [ISSN] 1051-2284
  • [Journal-full-title] Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • [ISO-abbreviation] J Neuroimaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Yen CP, Sheehan J, Steiner M, Patterson G, Steiner L: Gamma knife surgery for focal brainstem gliomas. J Neurosurg; 2007 Jan;106(1):8-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife surgery for focal brainstem gliomas.
  • OBJECT: Focal tumors, a distinct subgroup of which is composed of brainstem gliomas, may have an indolent clinical course.
  • In the present study the authors assess clinical and imaging results in 20 patients who harbored focal brainstem gliomas treated with GKS between 1990 and 2001.
  • The mean tumor volume at the time of GKS was 2.5 cm3.
  • In 10 cases a tumor specimen was obtained either by open surgery or stereotactic biopsy, securing the diagnosis of pilocytic astrocytoma in five patients and nonpilocytic astrocytoma in five others.
  • Another patient whose tumor disappeared 3 years following GKS died of stroke 8 years postoperatively.
  • Tumor progression occurred in four patients; of these four, one patient developed hydrocephalus requiring a ventriculoperitoneal shunt, two showed neurological deterioration, and one 4-year-old boy died of tumor progression.
  • CONCLUSIONS: Gamma Knife surgery may be an effective primary treatment or adjunct to open surgery for focal brainstem gliomas.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Glioma / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome. Tumor Burden

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  • [CommentIn] J Neurosurg. 2007 Sep;107(3):708; author reply 708-9 [17886574.001]
  • [CommentIn] J Neurosurg. 2007 Jan;106(1):6-7 [17262931.001]
  • (PMID = 17236482.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Colletti V, Shannon RV: Open set speech perception with auditory brainstem implant? Laryngoscope; 2005 Nov;115(11):1974-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Open set speech perception with auditory brainstem implant?
  • OBJECTIVE: Only a small percentage of auditory brainstem implant (ABI) recipients treated for neurofibromatosis type 2 (NF2) have proved capable of identifying words using only the sound from the ABI.
  • In the present study, a series of psychophysical tests were administered to determine the cause of the difference in performance between tumor (T) and nontumor (NT) ABI patients.
  • In NF2 patients, the tumor and surgery may selectively damage this pathway, resulting in poor speech recognition with prosthetic stimulation.
  • [MeSH-major] Auditory Brain Stem Implantation / instrumentation. Auditory Brain Stem Implants. Hearing Loss, Central / rehabilitation. Speech Perception / physiology. Vestibulocochlear Nerve Diseases / rehabilitation
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Follow-Up Studies. Humans. Infant. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 16319608.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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25. Colletti L, Zoccante L: Nonverbal cognitive abilities and auditory performance in children fitted with auditory brainstem implants: preliminary report. Laryngoscope; 2008 Aug;118(8):1443-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonverbal cognitive abilities and auditory performance in children fitted with auditory brainstem implants: preliminary report.
  • OBJECTIVES/HYPOTHESIS: Auditory brainstem implants (ABIs) can provide excellent open set speech recognition in adults without auditory tumors.
  • From 2000 to 2006, 17 children aged 14 months to 16 years received an ABI for different tumor and nontumor diseases in our department in Verona, and nine children were operated in other countries.
  • Intraoperative and postoperative electrically evoked auditory brainstem responses were performed in all children.
  • [MeSH-major] Auditory Brain Stem Implants. Cognition Disorders / rehabilitation. Deafness / rehabilitation. Nonverbal Communication
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Comprehension. Humans. Infant. Middle Aged. Treatment Outcome

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  • (PMID = 18496153.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Zhou LF, Du G, Mao Y, Zhang R: Diagnosis and surgical treatment of brainstem hemangioblastomas. Surg Neurol; 2005 Apr;63(4):307-15; discussion 315-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and surgical treatment of brainstem hemangioblastomas.
  • OBJECTIVE: The study aims to elucidate the advance of diagnosis and surgical treatment of brainstem hemangioblastomas (BSHs).
  • (1) patients with a single tumor on the brainstem which was verified by surgery and pathology;.
  • Extra-brainstem (EBS) type (including the fourth-ventricle hemangioblastomas) was seen in 25 cases, and intrabrainstem (IBS) type in 8 cases.
  • Total tumor removal was achieved in 31 patients (94%), and incomplete removal in 2 cases.
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Humans. Hyperthermia, Induced. Hypotension. Male. Middle Aged. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 15808704.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Uchino M, Haga D, Nomoto J, Mito T, Kuramitsu T: Brainstem involvement in hypertensive encephalopathy: a report of two cases and literature review. Eur Neurol; 2007;57(4):223-6
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  • [Title] Brainstem involvement in hypertensive encephalopathy: a report of two cases and literature review.
  • The cerebral hemispheres show prominent involvement in hypertensive encephalopathy far more frequently than the brainstem.
  • Two patients with severe paroxysmally accelerated hypertension associated with brainstem hyperintensity in T2-weighted magnetic resonance images are presented.
  • Extreme acceleration of hypertension may be essential for breakdown of autoregulation in the brainstem circulation.
  • The marked clinicoradiologic dissociation ruled out major brainstem infarction and made tumor unlikely.
  • [MeSH-major] Brain Stem / pathology. Hypertensive Encephalopathy / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Blood Pressure / drug effects. Cerebral Hemorrhage / radiography. Confusion / etiology. Confusion / psychology. Headache / etiology. Humans. Injections, Intravenous. Male. Nitroprusside / administration & dosage. Nitroprusside / therapeutic use. Tomography, X-Ray Computed. Vasodilator Agents / administration & dosage. Vasodilator Agents / therapeutic use. Verapamil / therapeutic use

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17312370.001).
  • [ISSN] 1421-9913
  • [Journal-full-title] European neurology
  • [ISO-abbreviation] Eur. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Vasodilator Agents; 169D1260KM / Nitroprusside; CJ0O37KU29 / Verapamil
  • [Number-of-references] 25
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28. Shih C, Tseng FY, Yeh TH, Hsu CJ, Chen YS: Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma. Otolaryngol Head Neck Surg; 2009 Dec;141(6):695-700
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  • [Title] Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma.
  • OBJECTIVE: To analyze auditory brainstem response (ABR) data in patients with vestibular schwannomas (VS) in an effort to identify correlations between abnormal ABR parameters and tumor size.
  • Average VS tumor size was 2.48 +/- 1.31 cm.
  • Tumor size was positively correlated with pure-tone average (P = 0.0106) and with the total number of bilateral abnormal ABR parameters (P = 0.004).
  • CONCLUSIONS: We identified a correlation between ABR parameters and VS tumor size.
  • An ipsilateral ILD-I-V greater than 0.2 ms was sensitive for detecting vs. Abnormal contralateral wave V and interpeak III-V latency indicated a tumor size potentially larger than 2 cm.
  • [MeSH-major] Evoked Potentials, Auditory, Brain Stem / physiology. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry, Pure-Tone. Cross-Sectional Studies. Female. Humans. Linear Models. Male. Middle Aged. Retrospective Studies. Vestibular Function Tests

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  • (PMID = 19932840.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Torcuator R, Zuniga R, Loutfi R, Mikkelsen T: Bevacizumab and irinotecan treatment for progressive diffuse brainstem glioma: case report. J Neurooncol; 2009 Jul;93(3):409-12
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  • [Title] Bevacizumab and irinotecan treatment for progressive diffuse brainstem glioma: case report.
  • Diffuse brainstem glioma carries a dismal prognosis.
  • In this paper, we report our experience in an adult patient with progressive diffuse brainstem glioma treated with bevacizumab and irinotecan.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy
  • [MeSH-minor] Adult. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Bevacizumab. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Radiotherapy

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  • [CommentIn] J Neurooncol. 2009 Nov;95(2):299-300 [19506812.001]
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  • (PMID = 19139822.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0H43101T0J / irinotecan; 2S9ZZM9Q9V / Bevacizumab; XT3Z54Z28A / Camptothecin
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30. Ushio M, Iwasaki S, Chihara Y, Kawahara N, Morita A, Saito N, Murofushi T: Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response? Acta Otolaryngol; 2009 Oct;129(10):1095-100
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  • [Title] Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response?
  • CONCLUSIONS: The results of the caloric test, vestibular evoked myogenic potential (VEMP), and auditory brainstem response (ABR) in patients with vestibular schwannoma (VS) did not show clear correlation with the nerve origin of the tumor but with tumor size.
  • When we focused on patients with VS within the internal acoustic canal (IAC), neither the nerve origin of the tumor nor the tumor size showed clear correlation with the results of these tests.
  • Tumor size was measured with preoperative MRI.
  • RESULTS: The nerve origin of the tumor was identified in 63 of the 109 patients.
  • Mean tumor size in patients showing abnormal responses was larger than that in patients showing normal responses on each test.
  • [MeSH-minor] Adult. Aged. Caloric Tests. Evoked Potentials, Auditory, Brain Stem. Humans. Middle Aged. Vestibular Evoked Myogenic Potentials. Vestibular Nerve / pathology. Vestibular Nerve / physiopathology. Young Adult

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  • (PMID = 19034733.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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31. Colletti V, Shannon R, Carner M, Veronese S, Colletti L: Outcomes in nontumor adults fitted with the auditory brainstem implant: 10 years' experience. Otol Neurotol; 2009 Aug;30(5):614-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes in nontumor adults fitted with the auditory brainstem implant: 10 years' experience.
  • OBJECTIVES: Recently, open-set speech recognition performance has been observed with electric stimulation of the brainstem in some nontumor (NT) patients.
  • These outcomes require that we reevaluate the criteria for patient selection and the rationale for expanding the application for the auditory brainstem implant (ABI) to NT adult patients with profound hearing loss.
  • MATERIALS AND METHODS: In our Department, from April 1997 to September 2007, ABIs have been implanted in 112 patients (83 adults and 29 children) with tumor (T) and NT disorders.
  • [MeSH-major] Auditory Brain Stem Implantation. Hearing Loss / surgery
  • [MeSH-minor] Adult. Cochlea / abnormalities. Cochlear Diseases / pathology. Cochlear Diseases / surgery. Cochlear Nerve / pathology. Craniocerebral Trauma / pathology. Craniocerebral Trauma / surgery. Female. Follow-Up Studies. Hearing Tests. Humans. Male. Peripheral Nervous System Diseases / pathology. Peripheral Nervous System Diseases / surgery. Retrospective Studies. Treatment Outcome

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  • (PMID = 19546832.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Davidson L, Zada G, Yu C, Petrovich Z, Pagnini PG, Zee CS, Giannotta SL, Zelman V, Apuzzo ML: Delayed toxicity from gamma knife radiosurgery to lesions in and adjacent to the brainstem. J Clin Neurosci; 2009 Sep;16(9):1139-47
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  • [Title] Delayed toxicity from gamma knife radiosurgery to lesions in and adjacent to the brainstem.
  • The aims of this study were to assess the incidence of, and risk factors for, delayed toxicity following gamma knife stereotactic radiosurgery (GKRS) to lesions in and adjacent to the brainstem.
  • We retrospectively evaluated the delayed toxicity of GKRS following the treatment of 114 lesions in and adjacent to the brainstem in 107 patients.
  • The median tumor volume was 6.2 cm(3) and the median dose to the tumor margin was 16Gy.
  • Larger tumor volume (p=0.02) and larger treatment volume (p=0.04) were associated with an increased incidence of delayed toxicity.
  • Large lesions adjacent to the brainstem have a higher than previously suspected rate of delayed toxicity.
  • [MeSH-major] Brain Diseases / etiology. Brain Diseases / pathology. Brain Stem / pathology. Brain Stem / surgery. Postoperative Complications / epidemiology. Postoperative Complications / psychology. Radiosurgery / adverse effects
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / surgery. Child. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Nervous System Diseases / epidemiology. Nervous System Diseases / etiology. Retrospective Studies. Risk Factors. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 19576781.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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33. Burzynski SR, Janicki TJ, Weaver RA, Burzynski B: Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma. Integr Cancer Ther; 2006 Mar;5(1):40-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma.
  • BACKGROUND: Brainstem glioma carries the worst prognosis of all malignancies of the brain.
  • Most patients with brainstem glioma fail standard radiation therapy and chemotherapy and do not survive longer than 2 years.
  • Treatment is even more challenging when an inoperable tumor is of high-grade pathology (HBSG).
  • CONCLUSION: Antineoplastons contributed to more than a 5-year survival in recurrent diffuse intrinsic glioblastomas and anaplastic astrocytomas of the brainstem in a small group of patients.
  • [MeSH-major] Benzeneacetamides / administration & dosage. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy. Glutamine / analogs & derivatives. Neoplasm Recurrence, Local / drug therapy. Phenylacetates / administration & dosage. Piperidones / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Combinations. Female. Follow-Up Studies. Humans. Injections, Intravenous. Magnetic Resonance Imaging. Male. Maximum Tolerated Dose. Neoplasm Staging. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 16484713.001).
  • [ISSN] 1534-7354
  • [Journal-full-title] Integrative cancer therapies
  • [ISO-abbreviation] Integr Cancer Ther
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzeneacetamides; 0 / Drug Combinations; 0 / Phenylacetates; 0 / Piperidones; 0RH81L854J / Glutamine; 104624-98-8 / antineoplaston AS 2-1; 91531-30-5 / antineoplaston A10
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34. Gorgulho A, De Salles AA, McArthur D, Agazaryan N, Medin P, Solberg T, Mattozo C, Ford J, Lee S, Selch MT: Brainstem and trigeminal nerve changes after radiosurgery for trigeminal pain. Surg Neurol; 2006 Aug;66(2):127-35; discussion 135
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brainstem and trigeminal nerve changes after radiosurgery for trigeminal pain.
  • Twenty-nine had ETN, 5 secondary TN due to tumor or multiple sclerosis, and 3 had atypical TN.
  • Enhancement on MRIs was observed in 21 cases (56.75%) with nerve enhancement in 9, pons enhancement in 4, pons-nerve enhancement in 4, and tumor enhancement in 4.
  • Paresthesias correlated with enhancement (P = .02), but not with brainstem volume encompassed by the 20%, 30%, and 50% isodoseline (P = .689, .525, .908).
  • Radiation delivery to the brainstem-REZ interface seems to improve pain outcome, although more paresthesias should be expected.
  • [MeSH-major] Brain Stem / pathology. Radiosurgery. Trigeminal Nerve / pathology. Trigeminal Neuralgia / pathology. Trigeminal Neuralgia / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Incidence. Magnetic Resonance Imaging. Male. Middle Aged. Paresthesia / epidemiology. Treatment Outcome

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  • (PMID = 16876597.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Acioly MA, Carvalho CH, Koerbel A, Löwenheim H, Tatagiba M, Gharabaghi A: Intraoperative brainstem auditory evoked potential observations after trigeminocardiac reflex during cerebellopontine angle surgery. J Neurosurg Anesthesiol; 2010 Oct;22(4):347-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative brainstem auditory evoked potential observations after trigeminocardiac reflex during cerebellopontine angle surgery.
  • BACKGROUND: The occurrence of trigeminocardiac reflex (TCR) is known to be a negative prognostic factor for hearing preservation in cerebellopontine angle tumor surgery.
  • Our study was conducted to investigate brainstem auditory evoked potential (BAEP) changes after this reflex in cerebellopontine angle tumor surgery and to evaluate their impact on postoperative hearing function.
  • [MeSH-major] Cerebellopontine Angle / surgery. Evoked Potentials, Auditory, Brain Stem / physiology. Heart / physiology. Reflex / physiology. Trigeminal Nerve / physiology
  • [MeSH-minor] Adolescent. Adult. Anesthesia. Audiometry, Pure-Tone. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Epidermal Cyst / surgery. Female. Hearing. Humans. Male. Meningioma / surgery. Monitoring, Intraoperative. Neurilemmoma / surgery. Prognosis. Treatment Outcome

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  • (PMID = 20706143.001).
  • [ISSN] 1537-1921
  • [Journal-full-title] Journal of neurosurgical anesthesiology
  • [ISO-abbreviation] J Neurosurg Anesthesiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. Nakamura M, Roser F, Dormiani M, Samii M, Matthies C: Intraoperative auditory brainstem responses in patients with cerebellopontine angle meningiomas involving the inner auditory canal: analysis of the predictive value of the responses. J Neurosurg; 2005 Apr;102(4):637-42
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  • [Title] Intraoperative auditory brainstem responses in patients with cerebellopontine angle meningiomas involving the inner auditory canal: analysis of the predictive value of the responses.
  • The aim of this retrospective study was to investigate the reliability and predictive importance of auditory brainstem responses (ABRs) for the determination of postoperative auditory function in patients with CPA meningiomas in comparison with results obtained in patients who undergo surgery for vestibular schwannomas.
  • On analysis, ABR monitoring demonstrated stable findings in 24 patients throughout tumor resection and fluctuating signals in 10 patients.
  • [MeSH-minor] Adult. Aged. Cerebellopontine Angle. Ear, Inner / pathology. Ear, Inner / physiology. Evoked Potentials, Auditory. Female. Humans. Intraoperative Period. Male. Middle Aged. Neuroma, Acoustic / complications. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 15871505.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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37. Grayeli AB, Kalamarides M, Bouccara D, Ambert-Dahan E, Sterkers O: Auditory brainstem implant in neurofibromatosis type 2 and non-neurofibromatosis type 2 patients. Otol Neurotol; 2008 Dec;29(8):1140-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory brainstem implant in neurofibromatosis type 2 and non-neurofibromatosis type 2 patients.
  • OBJECTIVE: To evaluate the auditory brainstem implant (ABI) performances in neurofibromatosis type 2 (NF2) and non-NF2 patients.
  • PATIENTS: Between 1996 and 2006, 31 adult patients (mean age, 41 yr; range, 17-65 yr) were implanted with a 21-electrode Nucleus device (Cochlear Inc., Lane Cove, Australia).
  • INTERVENTION: Auditory brainstem implant was placed through a translabyrinthine or a retrosigmoid approach.
  • MAIN OUTCOME MEASURES: Auditory brainstem implant was evaluated by open-set words and sentences in sound, vision, and sound-plus-vision modes.
  • CONCLUSION: A clear benefit of ABI could be evidenced in NF2 patients, especially in case of small tumor and short duration of hearing loss.
  • Auditory brainstem implant may also be indicated in patients with bilateral profound hearing loss and a predictable failure of cochlear implantation.
  • [MeSH-major] Auditory Brain Stem Implantation / methods. Hearing Aids. Neurofibromatosis 2 / surgery. Prosthesis Implantation / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Cochlea / pathology. Cohort Studies. Ear, Inner / abnormalities. Electric Stimulation. Evoked Potentials, Auditory / physiology. Humans. Meningitis / complications. Middle Aged. Neuroma, Acoustic / surgery. Ossification, Heterotopic / etiology. Otosclerosis / complications. Retrospective Studies. Young Adult

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  • (PMID = 18849886.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Vincenti V, Pasanisi E, Guida M, Di Trapani G, Sanna M: Hearing rehabilitation in neurofibromatosis type 2 patients: cochlear versus auditory brainstem implantation. Audiol Neurootol; 2008;13(4):273-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing rehabilitation in neurofibromatosis type 2 patients: cochlear versus auditory brainstem implantation.
  • OBJECTIVE: We aimed to evaluate and compare the auditory performance of neurofibromatosis type 2 (NF2) patients with bilateral total deafness fitted with cochlear or auditory brainstem implants.
  • Nine patients suffering from NF2 who underwent hearing rehabilitation by means of cochlear (4 patients) or auditory brainstem (5 patients) implantation participated in the study.
  • RESULTS: In the group of patients fitted with a cochlear implant, 3 subjects achieved open-set speech recognition abilities comparable to those of standard adult postlingual implant patients; the remaining patient scored 0% in all open-set format tests, reporting benefits only in environmental sound detection and lip-reading.
  • Among the 5 patients who underwent auditory brainstem implantation, 1 reached good open-set speech recognition skills, scoring 70% in the common phrases comprehension test, and she was able to communicate on the telephone.
  • In this small cohort, cochlear implant patients performed better than auditory brainstem implant patients, even if variability in auditory performance was observed with both devices.
  • More studies are needed in order to clarify the role and reliability of electrophysiological tests in predicting the residual functionality of the cochlear nerve after tumor removal.
  • [MeSH-major] Auditory Brain Stem Implants. Cochlear Implantation / methods. Deafness / rehabilitation. Neurofibromatosis 2 / rehabilitation. Neuroma, Acoustic / rehabilitation. Speech Reception Threshold Test
  • [MeSH-minor] Adult. Audiometry, Pure-Tone. Female. Humans. Male. Middle Aged. Prosthesis Design. Retrospective Studies


39. Cobb WS, Makosch G, Anand VK, Schwartz TH: Endoscopic transsphenoidal, transclival resection of an enterogenous cyst located ventral to the brainstem: case report. Neurosurgery; 2010 Dec;67(2 Suppl Operative):522-6
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  • [Title] Endoscopic transsphenoidal, transclival resection of an enterogenous cyst located ventral to the brainstem: case report.
  • We describe a method for resection of an enterogenous cyst located anterior to the brainstem via the endoscopic transsphenoidal approach.
  • CLINICAL PRESENTATION: A 37-year-old man was found to have a 2-cm mass anterior to the brainstem during routine screening after a trauma.
  • A minimally invasive endoscopic endonasal transsphenoidal transclival approach was performed for gross total resection of the tumor.
  • CONCLUSION: We discuss the endoscopic transsphenoidal approach used for the resection of an enterogenous cyst in the posterior fossa anterior to the brainstem.
  • The transsphenoidal approach provides direct access to lesions in this location using a minimally invasive technique while avoiding excessive brain retraction or injury to cranial nerves.
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 21099582.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Gouveris H, Mann W: Association between surgical steps and intraoperative auditory brainstem response and electrocochleography waveforms during hearing preservation vestibular schwannoma surgery. Eur Arch Otorhinolaryngol; 2009 Feb;266(2):225-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between surgical steps and intraoperative auditory brainstem response and electrocochleography waveforms during hearing preservation vestibular schwannoma surgery.
  • Intraoperative monitoring of the auditory pathway by means of either electrocochleography or auditory brainstem response audiometry is valuable during hearing preservation vestibular schwannoma (VS) surgery.
  • Most frequently, drilling of the internal auditory canal and direct tumor resection were associated with the aforementioned changes, but also drilling of the cortical temporal bone at the very beginning of surgery or the opening of the dura could be implicated.
  • [MeSH-major] Audiometry, Evoked Response / methods. Evoked Potentials, Auditory, Brain Stem. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Cohort Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Postoperative Complications / physiopathology. Risk Assessment. Sensitivity and Specificity. Treatment Outcome. Young Adult

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  • (PMID = 18553092.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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41. Prabhu K, Daniel RT, Mani S, Chacko AG: Dermoid tumor with diastematobulbia. Surg Neurol; 2009 Dec;72(6):717-21; discussion 721

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  • [Title] Dermoid tumor with diastematobulbia.
  • Dermoid tumor with diastematobulbia is very rare.
  • CASE DESCRIPTION: We report a dermoid tumor in an adult female with an unusual location and morphology.
  • The anterior part of the lesion was situated in the prepontine cistern and encircling the anterior half of the brainstem.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Cerebral Ventricle Neoplasms / surgery. Cisterna Magna / surgery. Dermoid Cyst / surgery. Fourth Ventricle / surgery. Medulla Oblongata / surgery. Neoplasms, Multiple Primary / surgery. Pons / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neural Tube Defects / diagnosis. Neural Tube Defects / pathology. Neural Tube Defects / surgery. Neurologic Examination. Postoperative Complications / diagnosis

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608253.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Fouladi M, Nicholson HS, Zhou T, Laningham F, Helton KJ, Holmes E, Cohen K, Speights RA, Wright J, Pollack IF, Children's Oncology Group: A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study. Cancer; 2007 Dec 1;110(11):2535-41
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  • [Title] A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study.
  • BACKGROUND: An open-label Phase II study of tipifarnib was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB)/primitive neuroectodermal tumor (PNET), high-grade glioma (HGG), and diffuse intrinsic brainstem glioma (BSG).
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy. Medulloblastoma / drug therapy. Quinolones / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Female. Humans. Male. Neuroectodermal Tumors / drug therapy. Treatment Outcome


43. Zhang W, Li X, Zhang J, Luft A, Hanley DF, van Zijl P, Miller MI, Younes L, Mori S: Landmark-referenced voxel-based analysis of diffusion tensor images of the brainstem white matter tracts: application in patients with middle cerebral artery stroke. Neuroimage; 2009 Feb 1;44(3):906-13
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  • [Title] Landmark-referenced voxel-based analysis of diffusion tensor images of the brainstem white matter tracts: application in patients with middle cerebral artery stroke.
  • In this study, we developed and tested a new tool to perform brain normalization and voxel-based analysis of DTI data.
  • After landmark placement, highly elastic non-linear Large Deformation Diffeomorphic Metric Mapping (LDDMM) was driven by the landmarks to normalize the brainstem anatomy of normal subjects.
  • The approach was then applied to delineate brainstem tract abnormalities in patients with left chronic middle cerebral artery (MCA) stroke.
  • We believe that this tool is useful for regional brain normalization of patients with severe anatomical alterations, such as stroke, brain tumor, and lobectomy, for whom standard automated normalization tools may not work properly.

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  • (PMID = 18852056.001).
  • [ISSN] 1095-9572
  • [Journal-full-title] NeuroImage
  • [ISO-abbreviation] Neuroimage
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / U24 RR021382; United States / NCRR NIH HHS / RR / P41 RR015241-040003; United States / NCRR NIH HHS / RR / P41 RR015241-050003; United States / NICHD NIH HHS / HD / R03 HD037931-02; United States / NCRR NIH HHS / RR / P41 RR015241-09; United States / NIA NIH HHS / AG / R01 AG020012; United States / NCRR NIH HHS / RR / P41 RR015241-060003; United States / NINDS NIH HHS / NS / R01 NS024282; United States / NIA NIH HHS / AG / R01 AG020012-05; United States / NIA NIH HHS / AG / R01 AG020012-02; United States / NIA NIH HHS / AG / R01 AG020012-09; United States / NIA NIH HHS / AG / AG020012-07; United States / NIA NIH HHS / AG / AG020012-04; United States / NCRR NIH HHS / RR / P41RR015241; United States / NINDS NIH HHS / NS / 1R01 NS 24282-08; United States / NCRR NIH HHS / RR / RR015241-050003; United States / NCRR NIH HHS / RR / U24RR021382; United States / NIA NIH HHS / AG / R01 AG020012-06A1; United States / NIA NIH HHS / AG / R01 AG020012-03; United States / NIA NIH HHS / AG / AG020012-06A1; United States / NCRR NIH HHS / RR / RR015241-078615; United States / NIA NIH HHS / AG / AG020012-09; United States / NCRR NIH HHS / RR / RR015241-060003; United States / NICHD NIH HHS / HD / R03 HD037931; United States / NCRR NIH HHS / RR / RR021382-03; United States / NICHD NIH HHS / HD / HD037931-02; United States / NCRR NIH HHS / RR / RR015241-09; United States / NIA NIH HHS / AG / AG020012-05; United States / NIA NIH HHS / AG / R01AG20012; United States / NCRR NIH HHS / RR / P41 RR015241; United States / NIA NIH HHS / AG / R01 AG020012-07; United States / NCRR NIH HHS / RR / U24 RR021382-03; United States / NCRR NIH HHS / RR / RR015241-086350; United States / NCRR NIH HHS / RR / RR015241-040003; United States / NIA NIH HHS / AG / AG020012-02; United States / NIA NIH HHS / AG / R01 AG020012-04; United States / NIA NIH HHS / AG / P60AG 12583; United States / NCRR NIH HHS / RR / P41 RR015241-078615; United States / NICHD NIH HHS / HD / HD037931-01; United States / NIBIB NIH HHS / EB / P41 EB015909; United States / NIA NIH HHS / AG / P60 AG012583; United States / NCRR NIH HHS / RR / P41 RR015241-086350; United States / NICHD NIH HHS / HD / R03 HD037931-01; United States / NIA NIH HHS / AG / R01 AG020012-01
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS90635; NLM/ PMC2662766
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44. Schipani S, Jain R, Shah K, Rock JP, Movsas B, Rosenblum M, Ryu S: Clinical, dosimetric, and radiographic correlation of radiation injury involving the brainstem and the medial temporal lobes following stereotactic radiotherapy for neoplasms of central skull base. J Neurooncol; 2010 Jun;98(2):177-84
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  • [Title] Clinical, dosimetric, and radiographic correlation of radiation injury involving the brainstem and the medial temporal lobes following stereotactic radiotherapy for neoplasms of central skull base.
  • Mean time interval between SRT and detection of RI was 9 +/- 3, 18.5 +/- 5, and 13.5 months for brainstem, temporal lobe, and cerebellum/labyrinth lesions, respectively.
  • RI can occur around the skull base because of irregular shape of target tumor, its close proximity to normal brain parenchyma, and inhomogeneity of dose distribution.
  • Brainstem lesions occurred earlier than temporal lobe RI.
  • The majority of the RI lesions, not mixed with the tumor in this study, showed radiographic and clinical improvement with steroid and symptomatic treatments.
  • [MeSH-major] Brain Stem / pathology. Radiation Injuries / pathology. Radiosurgery / adverse effects. Skull Base Neoplasms / surgery. Temporal Lobe / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Male. Middle Aged. Radiometry / methods. Radiotherapy Dosage. Time Factors

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  • (PMID = 20376551.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Notarianni C, Akin M, Fowler M, Nanda A: Brainstem astroblastoma: a case report and review of the literature. Surg Neurol; 2008 Feb;69(2):201-5
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  • [Title] Brainstem astroblastoma: a case report and review of the literature.
  • BACKGROUND: Astroblastoma is a rare glial tumor that occurs mainly in the cerebral hemispheres of young adults.
  • Our purpose in writing this article is to report one case of astroblastoma located within the medulla and review the literature on this infrequent tumor.
  • Light microscopy demonstrated a papillary neoplasm composed of mildly pleomorphic cells with indistinct cytoplasmic borders.
  • Occasional rosettes of tumor cells were seen around blood vessels.
  • The tumor exhibited thickened but not hyalinized blood vessel walls.
  • The tumor cells exhibited strong staining for EMA and vimentin throughout the tissue section.
  • Neurofilament, CAM 5.2, and CK immunostains were negative, except for rare positive staining of CK between cells and within rare tumor cells.
  • Ki-67 was positive in small numbers of tumor nuclei, with an overall reactivity of 7%.
  • By electron microscopy, the tumor nuclei had irregularly round to oval nuclei with moderate clumping of the chromatin, especially at the nuclear margins.
  • CONCLUSIONS: The combination of the radiologic and histopathologic characteristics of this tumor is necessary for making the diagnosis of astroblastoma.
  • This article serves to summarize these characteristics as well as to report of an unusual location for this mainly hemispheric tumor.
  • [MeSH-major] Brain Stem Neoplasms / diagnosis. Neoplasms, Neuroepithelial / diagnosis
  • [MeSH-minor] Adult. Female. Humans

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  • (PMID = 17765957.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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46. Araneda S, Commin L, Atlagich M, Kitahama K, Parraguez VH, Pequignot JM, Dalmaz Y: VEGF overexpression in the astroglial cells of rat brainstem following ozone exposure. Neurotoxicology; 2008 Nov;29(6):920-7
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  • [Title] VEGF overexpression in the astroglial cells of rat brainstem following ozone exposure.
  • Vascular endothelial growth factor (VEGF) is a factor associated with cellular recovery following brain injury.
  • Adult rats were subjected to 0.5ppm ozone for 3h and then recovered for further 3h.
  • The VEGF up-regulation which persists after ozone exposure may contribute to brain repair and consecutive functional adaptations.
  • [MeSH-minor] Animals. Glial Fibrillary Acidic Protein / metabolism. Interleukin-6 / metabolism. Male. Rats. Rats, Sprague-Dawley. Time Factors. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 18848842.001).
  • [ISSN] 0161-813X
  • [Journal-full-title] Neurotoxicology
  • [ISO-abbreviation] Neurotoxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Interleukin-6; 0 / Oxidants, Photochemical; 0 / Tumor Necrosis Factor-alpha; 0 / Vascular Endothelial Growth Factor A; 66H7ZZK23N / Ozone
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47. Caprile T, Salazar K, Astuya A, Cisternas P, Silva-Alvarez C, Montecinos H, Millán C, de Los Angeles García M, Nualart F: The Na+-dependent L-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids. J Neurochem; 2009 Feb;108(3):563-77
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  • [Title] The Na+-dependent L-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids.
  • As the brain does not synthesize AA, high levels are achieved in this organ by specific uptake mechanisms, which concentrate AA from the bloodstream to the CSF and from the CSF to the intracellular compartment.
  • In the adult brain the expression of SVCT2 was observed in the hippocampus and cortical neurons by in situ hybridization; however, there is no data regarding the expression and distribution of this transporter in the fetal brain.
  • We analyze SVCT2 expression in human and rat developing brain by RT-PCR.
  • Additionally, we study the normal localization of SVCT2 in rat fetal brain by immunohistochemistry and in situ hybridization demonstrating that SVCT2 is highly expressed in the ventricular and subventricular area of the rat brain.
  • SVCT2 expression and function was also confirmed in neurons isolated from brain cortex and cerebellum.
  • Our data demonstrates that brain cortex and cerebellar stem cells, neurons and neuroblastoma cells express SVCT2.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Stem / metabolism. Flavonoids / pharmacology. Neuroblastoma / metabolism. Neurons / metabolism. Organic Anion Transporters, Sodium-Dependent / antagonists & inhibitors. Organic Anion Transporters, Sodium-Dependent / biosynthesis. Sodium / physiology. Symporters / antagonists & inhibitors. Symporters / biosynthesis
  • [MeSH-minor] Animals. Ascorbic Acid / metabolism. Blotting, Western. Cell Line, Tumor. Cerebellum / cytology. Cerebellum / drug effects. Cerebellum / metabolism. Cerebral Cortex / cytology. Cerebral Cortex / drug effects. Cerebral Cortex / metabolism. DNA, Complementary / biosynthesis. DNA, Complementary / genetics. Female. Humans. Immunohistochemistry. In Situ Hybridization. Kinetics. Mice. Pregnancy. Rats. Rats, Sprague-Dawley. Reverse Transcriptase Polymerase Chain Reaction. Sodium-Coupled Vitamin C Transporters

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  • (PMID = 19054284.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Flavonoids; 0 / Organic Anion Transporters, Sodium-Dependent; 0 / SLC23A1 protein, human; 0 / SLC23A2 protein, human; 0 / Slc23a1 protein, mouse; 0 / Slc23a1 protein, rat; 0 / Slc23a2 protein, mouse; 0 / Slc23a2 protein, rat; 0 / Sodium-Coupled Vitamin C Transporters; 0 / Symporters; 9NEZ333N27 / Sodium; PQ6CK8PD0R / Ascorbic Acid
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48. Carlson ML, Babovic-Vuksanovic D, Messiaen L, Scheithauer BW, Neff BA, Link MJ: Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis type 2. J Neurosurg; 2010 Jan;112(1):81-7
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  • [Title] Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis type 2.
  • The gene responsible for the development of NF2 acts as a tumor suppressor gene.
  • Compared with patients with sporadic tumors, NF2 patients having a germline tumor suppressor gene defect may be more prone to secondary malignancies after treatment involving radiation therapy.
  • [MeSH-major] Brain Stem Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Neurofibromatosis 2 / surgery. Radiosurgery / adverse effects. Rhabdomyosarcoma / etiology
  • [MeSH-minor] Adult. Brain Neoplasms / etiology. Brain Neoplasms / surgery. Brain Stem / pathology. Brain Stem / radiation effects. Brain Stem / surgery. Ear Neoplasms / etiology. Ear Neoplasms / surgery. Fatal Outcome. Female. Humans. Neurilemmoma / etiology. Neurilemmoma / surgery. Vestibular Diseases / etiology. Vestibular Diseases / surgery

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  • [ErratumIn] J Neurosurg. 2010 Jan;112(1):209. Scheithauer, Bernd B [corrected to Scheithauer, Bernd W]
  • (PMID = 19575577.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Sousa R, Sá G, Reimão S, Lopes L, Ruivo J, Albuquerque L, Campos J: [Adult cerebellar medulloblastoma: imaging findings in eight cases]. Acta Med Port; 2006 Nov-Dec;19(6):466-70
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  • [Title] [Adult cerebellar medulloblastoma: imaging findings in eight cases].
  • Medulloblastoma is a brain tumor of neuroepithelial origin, frequent in children but rare in adults.
  • We report CT and MRI imaging findings of 8 adult patients with cerebellar medulloblastoma.
  • Dural involvement was seen in 7, one of which with lateral venous sinus compromise, and brainstem invasion was seen in 1 case.
  • They should be considered in the differential diagnosis of cerebellar tumor in adults, especially if they are hyperdense on CT, with well defined margins, with superficial extension and with dural involvement.
  • [MeSH-minor] Adolescent. Adult. Cerebellum / pathology. Cerebellum / radiography. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17583605.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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50. Choi KD, Kim JS, Kim HJ, Koo JW, Kim JH, Kim CY, Oh CW, Kee HJ: Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor. Neurology; 2007 Sep 4;69(10):1050-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor.
  • RESULTS: The incidence of HIN was higher in the CPA tumor than in the UPV group (82 vs 34%, p < 0.01) and was also higher in the acute than in the chronic UPV group (60 vs 21%, p < 0.01).
  • Furthermore, HIN was more commonly ipsilesional (i-HIN) in the CPA tumor than in the UPV group (52 vs 8%, p < 0.01) and more commonly ipsilesional in the acute than in the chronic UPV group (21 vs 1%, p < 0.01).
  • Our study demonstrates that hyperventilation-induced nystagmus (HIN) beating to the side of reduced caloric response, hearing impairment, or abnormal auditory brainstem response responses may be a valuable sign for bedside detection of cerebellopontine angle (CPA) tumors.
  • CPA tumor should be a prime suspicion in patients with acute vertigo and ipsilesional HIN, especially when the vertigo accompanies hearing impairments.
  • [MeSH-minor] Adult. Aged. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Humans. Male. Middle Aged

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  • [ErratumIn] Neurology. 2010 Nov 30;75(22):2046
  • (PMID = 17785675.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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51. Menon G, Krishnakumar K, Nair S: Adult medulloblastoma: clinical profile and treatment results of 18 patients. J Clin Neurosci; 2008 Feb;15(2):122-6
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  • [Title] Adult medulloblastoma: clinical profile and treatment results of 18 patients.
  • The objective of this article is to examine the clinicoradiological features and surgical outcomes of adult patients (>16 years) with medulloblastoma.
  • The following variables were assessed by bivariate analyses: age, location of the lesion, brainstem invasion, extent of excision and histological subtype.
  • The tumor was located in the vermis in 12 patients (66.6%) and in the cerebellar hemisphere in six (16.6%).
  • MRI evidence of brainstem infiltration was seen in three patients (16.6%).
  • Desmoplastic variant histology was not observed to be a significant prognostic factor in the adult group while brain stem invasion carried a poor prognosis.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Statistics, Nonparametric. Treatment Outcome

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  • (PMID = 18078755.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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52. Colpan ME, Sekerci Z, Berk C: Bilateral reversible deafness after surgery for unilateral epidermoid tumor: an unusual complication: case report. Neurosurgery; 2005 Apr;56(4):E870; discussion E870
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  • [Title] Bilateral reversible deafness after surgery for unilateral epidermoid tumor: an unusual complication: case report.
  • OBJECTIVE AND IMPORTANCE: We present an unusual complication of bilateral hearing loss after surgery for unilateral epidermoid tumor situated at the right pontocerebellar junction.
  • A brainstem auditory evoked potential test confirmed this with reduced amplitudes and a prolonged I-V interval.
  • The tumor was completely excised, and all of the cranial nerves were preserved during the operation.
  • CONCLUSION: Controlled cerebrospinal fluid drainage during exposure and tumor excision may reduce the possibility of shift and traction on the neural structures and help to prevent ischemic injury.
  • Frequent irrigation of the surgical field and minimizing the spilling of the tumor contents may reduce the risk of chemical irritation.
  • [MeSH-minor] Adult. Functional Laterality. Humans. Male

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  • (PMID = 15792529.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Pitskhelauri DI, Konovalov AN, Kornienko VN, Serova NK, Arutiunov NV, Kopachev DN: Intraoperative direct third ventriculostomy and aqueductal stenting in deep-seated midline brain tumor surgery. Neurosurgery; 2009 Feb;64(2):256-66; discussion 266-7
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  • [Title] Intraoperative direct third ventriculostomy and aqueductal stenting in deep-seated midline brain tumor surgery.
  • OBJECTIVE: Surgical resection of deep-seated midline brain tumors does not always resolve obstruction of cerebrospinal fluid pathways, and an additional operation--ventricular shunting--is required.
  • To prevent postoperative obstructive hydrocephalus, we combine tumor removal and internal ventricular shunting in 1 stage.
  • METHODS: Between 2000 and 2006, 82 patients with deep-seated midline brain tumors (tumors of the third ventricle, pineal region, thalamus, upper brainstem, and superior half of the fourth ventricle) underwent 84 tumor resections with intraoperative internal ventricular shunting.
  • RESULTS: As most of the tumors had an infiltrative growth pattern, gross total tumor removal was achieved in only 31% of patients in this series.
  • CONCLUSION: Intraoperative direct third ventriculostomy and aqueductal stenting under direct visual control were found to be reliable methods of hydrocephalus management in patients with deep-seated midline brain tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Cerebral Ventricles / surgery. Cerebrospinal Fluid Shunts / instrumentation. Cerebrospinal Fluid Shunts / methods. Ventriculostomy / instrumentation. Ventriculostomy / methods
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Intraoperative Care / instrumentation. Intraoperative Care / methods. Male. Middle Aged. Treatment Outcome. Young Adult

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  • (PMID = 19190455.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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54. Fisher BJ, Dennis KE: Malignant epithelioid cranial nerve sheath tumor: case report of a radiation response. J Neurooncol; 2006 Jun;78(2):173-7
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  • [Title] Malignant epithelioid cranial nerve sheath tumor: case report of a radiation response.
  • The tumor was resected but residual tumor was present at the cut end of the infraorbital nerve, within the oral cavity and at the brainstem.
  • Tumor was controlled for 38 months and then radiographic recurrence was resected from the infratemporal fossa outside the irradiated field.A new primary MES tumor developed at 69 months at the C1/C2 root levels at the lower edge of the previously irradiated field.
  • It was subtotally resected but by 77 months residual tumor had grown inferiorly down to C5 so this area was re-irradiated with a complicated 7-field approach to spare spinal cord.
  • Initially the tumor responded but ultimately progressed posteriorly where radiation dose was limited by spinal cord tolerance.
  • The patient expired from brainstem compression 7 years after initial radiotherapy.
  • The long-term control of the original tumor despite positive margins argues for the use of radiotherapy in the treatment of these tumors.
  • [MeSH-minor] Adult. Facial Nerve / pathology. Facial Nerve / surgery. Humans. Male. Radiotherapy Dosage. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / surgery

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  • (PMID = 16557352.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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55. Popugaev KA, Savin IA, Goriachev AS, Kadashev BA: Hypothalamic injury as a cause of refractory hypotension after sellar region tumor surgery. Neurocrit Care; 2008;8(3):366-73
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  • [Title] Hypothalamic injury as a cause of refractory hypotension after sellar region tumor surgery.
  • INTRODUCTION: Fluid-resistant arterial hypotension can result in hypoperfusion of the brain and other organs.
  • Well-known causes of arterial hypotension in neurosurgical practice include cardiac failure, septic shock, adrenal insufficiency, brainstem, and cervical spinal cord damage.
  • Fluid-resistant arterial hypotension can occur in patients with brain edema without damage to brainstem when hypothalamic nuclei suffer.
  • CONCLUSION: Hypothalamic damage can result in life-threatening vasodilatory arterial hypotension after sellar region tumor surgery. beta-Sympatomimetics are indicated in cases with thyroid insufficiency.
  • [MeSH-major] Brain Neoplasms / surgery. Hypotension / physiopathology. Hypothalamus / injuries. Hypothalamus / physiopathology. Postoperative Complications / physiopathology. Sella Turcica
  • [MeSH-minor] Adult. Aged. Blood Pressure. Central Venous Pressure. Female. Humans. Hypothyroidism / etiology. Hypothyroidism / physiopathology. Hypovolemia / etiology. Hypovolemia / physiopathology. Male. Middle Aged. Phenylephrine / therapeutic use. Prospective Studies. Pulmonary Wedge Pressure. Stroke Volume. Vasoconstrictor Agents / therapeutic use

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  • (PMID = 18363043.001).
  • [ISSN] 1541-6933
  • [Journal-full-title] Neurocritical care
  • [ISO-abbreviation] Neurocrit Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasoconstrictor Agents; 1WS297W6MV / Phenylephrine
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56. Durko M, Jankowski A, Durko T, Gajewicz W, Pajor A: [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness]. Otolaryngol Pol; 2008;62(2):204-8
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  • [Title] [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness].
  • INTRODUCTION: Acoustic neuroma usually presents as an unilateral tumor, seldom - bilateral and rarely in coexistence with other central nervous system neoplasms.
  • Audiometry revealed moderate sensorineural hearing loss in left ear (for low and middle frequencies), brainstem auditory evoked potentials were absent on the left side and ENG examination showed left peripheral vestibular impairment.
  • [MeSH-minor] Adult. Audiometry, Pure-Tone. Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / etiology. Humans. Male. Tinnitus / diagnosis. Tinnitus / etiology. Treatment Outcome. Vertigo / diagnosis. Vertigo / etiology

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  • (PMID = 18637448.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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57. Yong RL, Westerberg BD, Dong C, Akagami R: Length of tumor-cochlear nerve contact and hearing outcome after surgery for vestibular schwannoma. J Neurosurg; 2008 Jan;108(1):105-10
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  • [Title] Length of tumor-cochlear nerve contact and hearing outcome after surgery for vestibular schwannoma.
  • OBJECTIVES: Tumor size is likely to be a major determinant of hearing preservation after surgery for vestibular schwannoma.
  • Findings in some large case series have not supported this concept, possibly due to variation in the technique used for tumor measurement.
  • The authors sought to determine if the length of tumor-cochlear nerve contact was predictive of hearing outcome in adults undergoing resection of a vestibular schwannoma.
  • Magnetic resonance images were reviewed and used to calculate the length of tumor-cochlear nerve contact.
  • Univariate analysis revealed that extracanalicular length of tumor-cochlear nerve contact (p = 0.0365), preoperative hearing class (p = 0.028), I-V interpeak latency of the brainstem auditory evoked potential (p = 0.021), and the interaural I-V interpeak latency difference (p = 0.018) were predictive of hearing outcome.
  • CONCLUSIONS: Vestibular schwannomas with greater lengths of tumor-cochlear nerve contact increase a patient's risk for hearing loss after surgery with attempted hearing preservation.
  • [MeSH-minor] Adult. Audiometry. Cohort Studies. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Predictive Value of Tests. Recovery of Function. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 18173318.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Kimura M, Onozawa M, Fujisaki A, Arakawa T, Takeda K, Dalmau J, Hattori K: Anti-Ma2 paraneoplastic encephalitis associated with testicular germ cell tumor treated by carboplatin, etoposide and bleomycin. Int J Urol; 2008 Oct;15(10):942-3
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  • [Title] Anti-Ma2 paraneoplastic encephalitis associated with testicular germ cell tumor treated by carboplatin, etoposide and bleomycin.
  • Anti-Ma2-associated encephalitis is a paraneoplastic disorder that predominantly affects the limbic system, diencephalon and brainstem, and is usually associated with tumors of the testis.
  • After three courses of carboplatin, etoposide and bleomycin for metastatic testicular germ-cell tumor, all elevated tumor markers normalized and the retroperitoneal metastases disappeared, but the neurological disorder deteriorated.
  • To our knowledge, this is the first case in which orchiectomy followed by carboplatin, etoposide and bleomycin for a testicular tumor with anti-Ma2 encephalitis was performed.
  • [MeSH-major] Antigens, Neoplasm / immunology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Germ Cell and Embryonal / therapy. Nerve Tissue Proteins / immunology. Orchiectomy. Paraneoplastic Syndromes, Nervous System / immunology. Paraneoplastic Syndromes, Nervous System / therapy. Testicular Neoplasms / therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Carboplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Male

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  • (PMID = 19138287.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Ma2 antigen; 0 / Nerve Tissue Proteins; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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59. Patel AJ, Fox BD, Fulkerson DH, Yallampalli S, Illner A, Whitehead WE, Curry DJ, Luerssen TG, Jea A: Posterior reversible encephalopathy syndrome during posterior fossa tumor resection in a child. J Neurosurg Pediatr; 2010 Oct;6(4):377-80
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  • [Title] Posterior reversible encephalopathy syndrome during posterior fossa tumor resection in a child.
  • In addition, a single case of intraoperative (posterior fossa craniotomy) PRES has been reported; however, this case occurred in an adult.
  • The authors present a clinically and radiographically documented case of intraoperative PRES complicating the resection of a posterior fossa tumor in a 6-year-old child.
  • During tumor resection, untoward force was used to circumferentially dissect the tumor, and excessive manipulation of the brainstem led to severe hypertension for a 10-minute period.
  • An immediate postoperative MR image was obtained to rule out residual tumor, but instead the image showed findings consistent with PRES.

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  • [CommentIn] J Neurosurg Pediatr. 2011 Nov;8(5):535; author's reply 535 [22044382.001]
  • (PMID = 20887113.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Waldron JS, Tihan T, Parsa AT: Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma. Neurosurgery; 2006 Oct;59(4):E939-40; discussion E940
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  • [Title] Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma.
  • OBJECTIVE: The authors present a report of a solitary fibrous tumor (SFT) arising from the intradural component of the VIth cranial nerve as it travels through the prepontine cistern.
  • Outside imaging revealed a 3.9-cm mass in the prepontine cistern with extension into Meckel's cave and the cavernous sinus, resulting in significant brainstem compression.
  • The patient was then taken to the operating room by a combined neurosurgical and ear, nose, and throat team, where the patient underwent a retrolabyrinthine/subtemporal craniotomy for tumor resection.
  • During resection of the prepontine component, the tumor was identified as originating from the left Cranial Nerve VI as it traversed through the prepontine cistern.
  • Resection of the tumor component involving the cavernous sinus and Meckel's cave was deferred for follow-up treatment with intensity-modulated radiation therapy.
  • [MeSH-minor] Adult. Cerebral Angiography. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Radiotherapy, Adjuvant

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  • (PMID = 17038929.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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61. Cho JM, Ahn JY, Kim SH, Lee KS, Chang JH: An endodermal cyst mimicking an intra-axial tumor in the medulla oblongata. Childs Nerv Syst; 2010 Jun;26(6):853-6
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  • [Title] An endodermal cyst mimicking an intra-axial tumor in the medulla oblongata.
  • Endodermal cysts are rarely intracranial, but when this occurs, the cysts are frequently located in the posterior fossa with the most common locations being anterior to the brainstem and within the fourth ventricle.
  • [MeSH-major] Brain Diseases / diagnosis. Brain Neoplasms / diagnosis. Cysts / diagnosis. Medulla Oblongata
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Treatment Outcome. Young Adult

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  • [CommentIn] Childs Nerv Syst. 2011 Jun;27(6):861-2; author reply 863 [21503756.001]
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  • (PMID = 20217097.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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62. Kobayashi H, Sawamura Y, Ikeda J: A tumor in the medulla oblongata producing beta-HCG and AFP. J Clin Neurosci; 2005 Aug;12(6):709-11
Hazardous Substances Data Bank. LINDANE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A tumor in the medulla oblongata producing beta-HCG and AFP.
  • Surgical resection should be carefully considered in patients with brainstem tumours with elevation of serum tumour markers as chemo- and radiotherapy may be effective for brainstem NGGCT.
  • [MeSH-major] Brain Stem Neoplasms / blood. Lindane / blood. Medulla Oblongata / pathology. Neoplasms / blood. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods

  • Hazardous Substances Data Bank. BETA-HEXACHLOROCYCLOHEXANE .
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  • (PMID = 16098752.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / alpha-Fetoproteins; 319-85-7 / beta-hexachlorocyclohexane; 59NEE7PCAB / Lindane
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63. Matsumura R, Umemiya K, Sugiyama T, Sueishi M, Umibe T, Ichikawa K, Yoshimura M, Study Group on Nephrology at the National Hospital Organization of Japan: Anti-tumor necrosis factor therapy in patients with difficult-to-treat lupus nephritis: a prospective series of nine patients. Clin Exp Rheumatol; 2009 May-Jun;27(3):416-21
Hazardous Substances Data Bank. Infliximab .

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  • [Title] Anti-tumor necrosis factor therapy in patients with difficult-to-treat lupus nephritis: a prospective series of nine patients.
  • In one patient in whom the steroid dosage was increased due to poor response to anti-TNF-alpha therapy, brainstem infarction occurred four months later.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antirheumatic Agents / therapeutic use. Lupus Nephritis / drug therapy. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Adult. Antibodies, Anti-Idiotypic / blood. DNA / immunology. Female. Follow-Up Studies. Humans. Infliximab. Lupus Erythematosus, Systemic / blood. Lupus Erythematosus, Systemic / complications. Lupus Erythematosus, Systemic / physiopathology. Male. Middle Aged. Prospective Studies. Proteinuria / etiology. Proteinuria / prevention & control. Severity of Illness Index. Treatment Outcome

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  • (PMID = 19604433.001).
  • [ISSN] 0392-856X
  • [Journal-full-title] Clinical and experimental rheumatology
  • [ISO-abbreviation] Clin. Exp. Rheumatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Antirheumatic Agents; 0 / Tumor Necrosis Factor-alpha; 9007-49-2 / DNA; B72HH48FLU / Infliximab
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64. Wu Z, Zhang J, Zhang L, Jia G, Tang J, Wang L, Wang Z: Prognostic factors for long-term outcome of patients with surgical resection of skull base chordomas-106 cases review in one institution. Neurosurg Rev; 2010 Oct;33(4):451-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The previous radiotherapy or surgery, dedifferentiated pathology, and less tumor resection are risk factors for longterm survival and recurrence (p < 0.05).
  • Although there is no statistic significant role of tumor adherent to vital structure for outcome (p = 0.051), it can not exclude its importance for favorable outcome.
  • Gender, age, tumor size and staging are not independent risk factors for outcome.
  • Surgical technique leading to radical tumor resection with less morbidity is advocatory and beneficial for patients with skull base chordoma with long term outcome, if the tumor could be exposed and resected completely, the recurrence rate was very low for most benign chordomas.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Karnofsky Performance Status. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Regression Analysis. Retrospective Studies. Risk Factors. Treatment Outcome. Young Adult

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  • (PMID = 20668904.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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65. Tibbetts KM, Emnett RJ, Gao F, Perry A, Gutmann DH, Leonard JR: Histopathologic predictors of pilocytic astrocytoma event-free survival. Acta Neuropathol; 2009 Jun;117(6):657-65
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  • Pilocytic astrocytoma (PA) is the most common pediatric brain tumor.
  • Most arise in the cerebellum, but they also can develop in the brainstem and optic nerve, where gross total resection (GTR) is not possible.
  • Lastly, we did find a statistical trend between EFS and the number of CD68+ cells, suggesting that non-neoplastic elements of the tumor microenvironment may influence subsequent growth and clinical recurrence.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Brain / pathology. Brain / physiopathology. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Immunohistochemistry. Infant. Male. Mitotic Index. Retrospective Studies. Signal Transduction. Tumor Suppressor Protein p53 / metabolism. Young Adult


66. Ugokwe K, Nathoo N, Prayson R, Barnett GH: Trigeminal nerve schwannoma with ancient change. Case report and review of the literature. J Neurosurg; 2005 Jun;102(6):1163-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, the tumor has biphasic features typical of a schwannoma with evidence of degenerative changes that may complicate diagnosis.
  • Magnetic resonance imaging demonstrated a rim-enhancing lesion in the cerebellopontine angle with displacement of brainstem structures and no supratentorial hydrocephalus.
  • At surgery, the tumor was found to arise from the inferior division of the trigeminal nerve.
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 16028782.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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67. Fayad JN, Keles B, Brackmann DE: Jugular foramen tumors: clinical characteristics and treatment outcomes. Otol Neurotol; 2010 Feb;31(2):299-305

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Presenting symptoms, otologic and neurotologic examination, audiologic thresholds, treatment procedure, surgical technique, tumor size and classification, and postoperative complications were recorded.
  • Extent of tumor removal was determined at time of surgery, followed by routine radiographic follow-up.
  • Total tumor removal was achieved in 81% of surgery cases.
  • However, subtotal removal may be required to preserve CN function, vital vascular structures, and the brainstem.
  • Postoperative radiotherapy is used to control residual tumor.
  • [MeSH-major] Glomus Jugulare Tumor / surgery. Meningioma / surgery. Neurilemmoma / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Audiometry, Pure-Tone. Cerebrovascular Circulation / physiology. Facial Nerve Diseases / etiology. Female. Humans. Laryngoscopy. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications / epidemiology. Retrospective Studies. Treatment Outcome

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  • (PMID = 19779386.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Tanaka K, Sasayama T, Kawamura A, Kondoh T, Kanomata N, Kohmura E: Isolated oculomotor nerve paresis in anaplastic astrocytoma with exophytic invasion. Neurol Med Chir (Tokyo); 2006 Apr;46(4):198-201
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  • Computed tomography and magnetic resonance imaging showed an intra-axial tumor in the left temporal lobe, extending to the basal and prepontine cisterns, and compressing the brainstem.
  • The tumor was removed subtotally.
  • [MeSH-minor] Adult. Astrocytes / pathology. Biomarkers, Tumor / analysis. Brain Stem / pathology. Cerebral Arteries / pathology. Cisterna Magna / pathology. Dominance, Cerebral / physiology. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology. Nerve Compression Syndromes / diagnosis. Nerve Compression Syndromes / etiology. Nerve Compression Syndromes / pathology. Nerve Compression Syndromes / surgery. Neuronavigation. Oculomotor Nerve / pathology. Oculomotor Nerve / surgery. Pons / pathology

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  • (PMID = 16636512.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Niranjan A, Kano H, Khan A, Kim IY, Kondziolka D, Flickinger JC, Lunsford LD: Radiosurgery for brain metastases from unknown primary cancers. Int J Radiat Oncol Biol Phys; 2010 Aug 1;77(5):1457-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for brain metastases from unknown primary cancers.
  • PURPOSE: We evaluated the role of Gamma Knife stereotactic radiosurgery in the multidisciplinary management of brain metastases from an undiagnosed primary cancer.
  • METHODS AND MATERIALS: Twenty-nine patients who had solitary or multiple brain metastases without a detectable primary site underwent stereotactic radiosurgery between January 1990 and March 2007 at the University of Pittsburgh.
  • RESULTS: After radiosurgery, the local tumor control rate was 88.5%.
  • Factors associated with poor progression-free survival included large tumor volume (3 cc or more) and brainstem tumor location.
  • CONCLUSIONS: Radiosurgery is an effective and safe minimally invasive option for patients with brain metastases from an unknown primary site.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Neoplasms, Unknown Primary. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / secondary. Brain Stem Neoplasms / surgery. Disease-Free Survival. Humans. Middle Aged. Radiotherapy Dosage. Survival Rate. Tumor Burden

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20056342.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Chung WY, Pan DH, Lee CC, Wu HM, Liu KD, Yen YS, Guo WY, Shiau CY, Shih YH: Large vestibular schwannomas treated by Gamma Knife surgery: long-term outcomes. J Neurosurg; 2010 Dec;113 Suppl:112-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: Although radiosurgery has been well accepted as a treatment for small- to medium-sized vestibular schwannomas (VSs), its application in the treatment of large VSs remains controversial because of unfavorable effects such as tumor swelling and potential compression of the brainstem.
  • Long-term outcomes are reported, and possible factors affecting tumor responses to GKS are analyzed.
  • A large VS was defined as a tumor whose diameter was > 3 cm.
  • Fourteen of these patients had undergone 1 or more craniotomies previously to remove the tumor.
  • The mean radiation dose directed to the tumor ranged from 15 to 17.5 Gy.
  • The mean radiation dose prescribed to the tumor margin was 11.9 Gy (range 11-14 Gy).
  • RESULTS: The tumor control rate was 90.5% (19 of 21 lesions).
  • Three of the 21 patients developed initial tumor swelling, which required minor surgical interventions, including aspiration using an Ommaya reservoir or placement of a ventriculoperitoneal shunt.
  • There was no significant correlation between tumor control and the following factors: patient age or sex, tumor volume, radiation dose, previous operation, presence of brainstem compression, petrous bone invasion, T2 signal ratio between tumor and brainstem, and presence of a cyst.
  • However, there was a significant correlation between the T2 signal ratio between tumor and brainstem and the duration of tumor swelling (p = 0.003).
  • Control of tumor growth and preservation of neurological function are the main goals of treatment.
  • Although delayed microsurgery was required in 2 patients (9.5%), the satisfactory tumor control rate and excellent preservation of facial and trigeminal nerve function are the great advantages of radiosurgery.
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Female. Humans. Magnetic Resonance Imaging. Male. Microsurgery / instrumentation. Middle Aged. Radiotherapy Dosage. Retrospective Studies. Statistics, Nonparametric. Treatment Outcome. Tumor Burden

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  • (PMID = 21121793.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Goutagny S, Bouccara D, Bozorg-Grayeli A, Sterkers O, Kalamarides M: [Neurofibromatosis type 2]. Rev Neurol (Paris); 2007 Sep;163(8-9):765-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • NF2 tumor suppressor gene encodes Merlin/Schwannomin, and is also involved in most sporadic schwannomas and meningiomas.
  • Auditory brainstem implant must be taken into account in hearing rehabilitation.
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / epidemiology. Ependymoma / genetics. Ependymoma / pathology. Female. Genes, Tumor Suppressor. Humans. Male. Middle Aged. Neurilemmoma / genetics. Neurilemmoma / pathology. Prognosis

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  • (PMID = 17878803.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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72. Tahara A, de Santana PA Jr, Calfat Maldaun MV, Panagopoulos AT, da Silva AN, Zicarelli CA, Pires de Aguiar PH: Petroclival meningiomas: surgical management and common complications. J Clin Neurosci; 2009 May;16(5):655-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They have a tendency to grow slowly, involve cranial nerves and compress the brainstem and basilar artery, pushing them to the opposite side.
  • The mortality rate was 13.5% due to surgical bed hematoma and brain ischemia.
  • Limiting factors for surgical removal are tumor consistency, encasement of brainstem perforators and pre-operative clinical status.
  • [MeSH-minor] Adult. Cranial Nerves / pathology. Cranial Nerves / surgery. Craniotomy / adverse effects. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Postoperative Complications. Retrospective Studies. Treatment Outcome

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  • (PMID = 19318254.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Scotland
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73. Luetjens G, Mirzayan MJ, Brandis A, Krauss JK: Exophytic giant cell glioblastoma of the medulla oblongata. J Neurosurg; 2009 Mar;110(3):589-93
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  • A giant cell glioblastoma may be associated with a better prognosis than the common type of GBM after combined treatment involving tumor resection and radiochemotherapy.
  • A giant cell glioblastoma may occur at various sites in the brain and spinal cord.
  • To the authors' knowledge, this type of tumor has not been previously reported as arising as an exophytic tumor from the medulla oblongata.
  • The authors report on a 40-year-old man who presented with a large tumor located in the caudal fourth ventricle.
  • The tumor was removed completely and the patient underwent percutaneous radiotherapy with 60 Gy and concomitant chemotherapy with temozolomide.
  • Histopathological examination of the tumor revealed the typical features of a giant cell glioblastoma.
  • At the 2-year follow-up the patient was doing well and showed no signs of tumor recurrence.
  • It is important to identify variants of GBM because they may predict favorable long-term outcome, even when they arise from the caudal brainstem.
  • [MeSH-major] Brain Neoplasms / pathology. Glioblastoma / pathology. Medulla Oblongata
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male

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  • (PMID = 19061354.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Feigl GC, Horstmann GA: Intracranial glomus jugulare tumors: volume reduction with Gamma Knife surgery. J Neurosurg; 2006 Dec;105 Suppl:161-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The treatment strategy was either multimodal, with microsurgical tumor volume reduction followed by GKS in patients suffering from brainstem compression, or GKS as the only treatment.
  • Follow-up examinations included thorough neurological examinations and neuroradiological quantitative volumetric tumor analysis.
  • Tumor volumes ranging from 1.6 to 24.8 cm3 were treated using prescription doses of 14 to 20 Gy (nine-28 isocenters).
  • The achieved overall tumor control rate after GKS was 100% (33 months mean follow up) with only mild side effects observed.
  • A tumor volume reduction (mean 41.1%; 3.2 cm3) was achieved in all patients.
  • The tumor volume reductions achieved are comparable to those achieved using microsurgery but with a much lower rate of side effects.
  • [MeSH-major] Glomus Jugulare Tumor / pathology. Glomus Jugulare Tumor / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Male. Middle Aged. Prospective Studies. Radiotherapy Dosage. Recovery of Function. Treatment Outcome. Tumor Burden

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  • (PMID = 18503351.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Wang EM, Pan L, Wang BJ, Zhang N, Zhou LF, Dong YF, Dai JZ, Cai PW, Chen H: The long-term results of gamma knife radiosurgery for hemangioblastomas of the brain. J Neurosurg; 2005 Jan;102 Suppl:225-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The long-term results of gamma knife radiosurgery for hemangioblastomas of the brain.
  • OBJECT: The authors assessed the long-term result of gamma knife surgery (GKS) for hemangioblastomas of the brain (HABs) and show histopathological findings after GKS.
  • Eighteen patients presented with multiple tumors and 17 with a solitary tumor.
  • The mean tumor diameter was 13 mm (range 5-55 mm).
  • The mean prescription dose was 17.2 Gy (range 12-24 Gy) at the tumor margin.
  • For tumors close to or within the brainstem a prescription dose of 12 to 13 Gy was used.
  • At the most recent follow up, 29 patients were alive, six were dead, and satisfactory tumor control had been achieved in 29.
  • Eight patients underwent open surgery because of tumor-associated cyst enlargement or the development of new tumors after GKS.
  • The 1-year tumor control rate was 94%; 2 years, 85%; 3 years, 82%; 4 years, 79%; and 5 years, 71%.
  • Histopathology showed that no tumor cells were found and there was degeneration and necrosis in a tumor nodule 48 months after GKS with a prescription dose of 18 Gy.
  • CONCLUSIONS: Gamma knife surgery was a useful choice for small- or medium-sized, solid HAB in the long term, especially when the tumor margin dose was 18 Gy.
  • Although GKS can treat multiple tumors in a single session, for HABs associated with VHL disease, GKS faces the dual problems of tumor recurrence or development of a new tumor.
  • [MeSH-major] Brain Neoplasms / surgery. Hemangioblastoma / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adolescent. Adult. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiation Dosage. Survival Rate. Time. von Hippel-Lindau Disease / mortality. von Hippel-Lindau Disease / pathology. von Hippel-Lindau Disease / surgery

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  • (PMID = 15662815.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Gerosa M, Mesiano N, Longhi M, De Simone A, Foroni R, Verlicchi A, Zanotti B, Nicolato A: Gamma Knife surgery in vestibular schwannomas: impact on the anterior and posterior labyrinth. J Neurosurg; 2010 Dec;113 Suppl:128-35
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  • OBJECT: During the past decades, in small-to-medium size vestibular schwannomas, Gamma Knife surgery (GKS) has become a reliable therapeutic option because of either excellent local tumor control or minimal morbidity, with cranial neuropathy becoming increasingly rare.
  • METHODS: A small group of patients with vestibular schwannomas (74 patients, including 41 men and 33 women) treated between 2003 and 2009 using GKS at the authors' institution were analyzed--both before and after GKS--with computerized static stabilometry and electronystagmography for balance disorders, vertigo, and ataxia on 1 side and pure tone average, vocal speech discrimination score, auditory brainstem response, and so forth for hearing impairment and tinnitus on the other side.
  • RESULTS: To date, tumor growth control rates remain satisfactory; at a mean follow-up of 50 months, the rate was 96%.
  • CONCLUSIONS: Using appropriate radiodosimetry planning, GKS seems to guarantee not only adequate tumor growth control rates, but also better levels of hearing preservation, with a documented, long-lasting improvement in vestibular functions.
  • [MeSH-minor] Adult. Aged. Audiometry. Auditory Threshold. Electronystagmography. Female. Follow-Up Studies. Hearing Disorders / etiology. Hearing Disorders / surgery. Humans. Male. Middle Aged. Prospective Studies. Radiotherapy Dosage. Treatment Outcome. Vestibular Diseases / etiology. Vestibular Diseases / surgery

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  • (PMID = 21121794.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Pichierri A, D'Avella E, Ruggeri A, Tschabitscher M, Delfini R: Endoscopic assistance in the epidural subtemporal approach and Kawase approach: anatomic study. Neurosurgery; 2010 Sep;67(3 Suppl Operative):ons29-37; discussion ons37
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  • METHODS: Twelve epidural subtemporal approaches were performed on 6 adult cadaveric heads.
  • Surgical freedom was limited by the brainstem and the depth of the posterior cranial fossa.
  • CONCLUSION: The endoscope-assisted subtemporal approach can be useful in visualizing tumor in the posterior fossa.
  • It can help the surgeon in planning further surgical steps through consideration of the size, extension, and adherence of the tumor to surrounding structures.

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  • (PMID = 20679951.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Miyatake S, Tamura Y, Kawabata S, Iida K, Kuroiwa T, Ono K: Boron neutron capture therapy for malignant tumors related to meningiomas. Neurosurgery; 2007 Jul;61(1):82-90; discussion 90-1
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  • RESULTS: Five of the six patients who underwent BPA-PET analysis showed good BPA uptake, with a greater than 2.7 tumor-to-healthy brain ratio.
  • The atypical meningioma case showed a tumor-to-healthy brain ratio of 2.0.
  • The original tumor sizes were between 13.6 and 109 ml.
  • In this patient, a huge atypical meningioma arose from the falcotentorial junction and extended to the bilateral occipital lobes and brainstem; visual problems worsened after repetitive BNCT, with an increase in peritumoral edema.
  • [MeSH-major] Boron Neutron Capture Therapy / methods. Brain Neoplasms / radionuclide imaging. Brain Neoplasms / radiotherapy. Meningeal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Brain Injuries / etiology. Brain Injuries / radionuclide imaging. Female. Humans. Male. Radiation Injuries / etiology. Radiation Injuries / radionuclide imaging. Treatment Outcome

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  • (PMID = 17621022.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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79. Stüer C, Vilz B, Majores M, Becker A, Schramm J, Simon M: Frequent recurrence and progression in pilocytic astrocytoma in adults. Cancer; 2007 Dec 15;110(12):2799-808
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  • BACKGROUND: Most pilocytic astrocytomas (piloA) are benign growths (World Health Organization [WHO] grade 1) of the deep midline structures, the brainstem, and the cerebellum.
  • RESULTS: There were 20 patients (45%) with supratentorial lobar piloA (including 10 temporal/temporomesial tumors, 5 parietal tumors, 3 insular tumors, 1 frontal tumor, and 1 occipital tumors), 12 patients with cerebellar piloA, 7 patients with brainstem piloA, 2 patients with opticochiasmatic PiloA, 1 patient with intramedullary piloA, and 2 patients with piloA of the basal ganglia.
  • All but 1 patient with a lobar tumor presented with epilepsy.
  • Tumor recurrence or disease progression was observed in 13 of 44 patients (30%).
  • CONCLUSIONS: PiloA in adult patients, surprisingly, often was not a benign disease.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / radiography. Brain Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Prognosis. Recurrence. Treatment Outcome

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  • [CommentIn] Nat Clin Pract Neurol. 2008 Jun;4(6):296-7 [18414467.001]
  • (PMID = 17973253.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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80. Tohmé A, Koussa S, Haddad-Zébouni S, El-Rassi B, Ghayad E: [Neurological manifestations of Behcet's disease: 22 cases among 170 patients]. Presse Med; 2009 May;38(5):701-9
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  • Meningoencephalitis and/or transverse myelitis were found in 57% (12/21) of cases (in association with brainstem syndrome in 2 of these cases), brainstem syndrome without meningoencephalitis in 5 cases, tumor-like syndrome in 2 cases, repetitive ischemic attacks in 1 case and cerebral venous thrombosis in one.
  • MRI, performed in 9 patients, was abnormal in 6 and showed abnormal signals distributed over the brainstem and the thalamus in 4, a tumor-like lesion and thrombosis of the left lateral sinus one each.
  • One patient who had brainstem syndrome died within 18 months because of a delayed corticosteroid treatment.
  • CONCLUSION: Within central neurological involvement in Behçet's disease, we can individualize 4 clinical aspects: meningoencephalitis (and/or myelitis), brainstem syndrome, tumor-like features and cerebral venous thrombosis.
  • Abnormalities, observed on CT Scan and MRI, by their brainstem localization and their multiplicity, should evoke the diagnosis.
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Brain / pathology. Female. Humans. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Sex Factors

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  • (PMID = 19062244.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Immunosuppressive Agents
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81. Hua C, Bass JK, Khan R, Kun LE, Merchant TE: Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose. Int J Radiat Oncol Biol Phys; 2008 Nov 1;72(3):892-9
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  • [Title] Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose.
  • PURPOSE: To determine the effect of cochlear dose on sensorineural hearing loss in pediatric patients with brain tumor treated by using conformal radiation therapy (CRT).
  • PATIENTS AND METHODS: We studied 78 pediatric patients (155 ears) with localized brain tumors treated in 1997-2001 who had not received platinum-based chemotherapy and were followed up for at least 48 months.
  • They were evaluated prospectively by means of serial pure-tone audiograms (250 Hz-8 kHz) and/or auditory brainstem response before and every 6 months after CRT.
  • In the absence of other factors, including ototoxic chemotherapy, increase in cochlear dose correlates positively with hearing loss in pediatric patients with brain tumor.
  • [MeSH-major] Audiometry, Pure-Tone. Brain Neoplasms / radiotherapy. Cochlea / radiation effects. Hearing Loss, Sensorineural / radionuclide imaging. Radiotherapy / adverse effects
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Incidence. Male. Radiotherapy Dosage. Retrospective Studies. Time Factors. Young Adult

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  • (PMID = 18395355.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Daly ME, Chen AM, Bucci MK, El-Sayed I, Xia P, Kaplan MJ, Eisele DW: Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):151-7
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  • Treatment plans were designed to provide a dose of 70 Gy to 95% or more of the gross tumor volume (GTV) and 60 Gy to 95% or more of the clinical tumor volume (CTV) while sparing neighboring critical structures including the optic chiasm, optic nerves, eyes, and brainstem.
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adenocarcinoma / secondary. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / secondary. Esthesioneuroblastoma, Olfactory / radiotherapy. Esthesioneuroblastoma, Olfactory / secondary. Female. Humans. Male. Middle Aged. Nasal Cavity. Neoplasm Staging. Radiation Injuries / etiology. Radiotherapy Dosage

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  • (PMID = 17189068.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Sandri A, Sardi N, Genitori L, Giordano F, Peretta P, Basso ME, Bertin D, Mastrodicasa L, Todisco L, Mussa F, Forni M, Ricardi U, Cordero di Montezemolo L, Madon E: Diffuse and focal brain stem tumors in childhood: prognostic factors and surgical outcome. Experience in a single institution. Childs Nerv Syst; 2006 Sep;22(9):1127-35
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  • [Title] Diffuse and focal brain stem tumors in childhood: prognostic factors and surgical outcome. Experience in a single institution.
  • OBJECTIVE: Brainstem tumors (BSTs) are usually gliomas and are divided into diffuse BSTs (DBSTs) and focal BSTs (FBSTs).
  • Eight out of 17 patients had adjuvant chemo- and/or radiotherapy after progression: 6/8 are without neurological symptoms and 2/8 have died due to tumor progression.
  • [MeSH-major] Astrocytoma / surgery. Brain Stem Neoplasms / surgery. Ganglioglioma / surgery
  • [MeSH-minor] Adolescent. Adult. Brain Stem / pathology. Brain Stem / surgery. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Cranial Irradiation. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Infant. Male. Prognosis. Radiation-Sensitizing Agents / administration & dosage. Radiotherapy, Adjuvant. Survival Rate. Vincristine / administration & dosage

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  • (PMID = 16568342.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiation-Sensitizing Agents; 5J49Q6B70F / Vincristine
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84. Pavesi G, Feletti A, Berlucchi S, Opocher G, Martella M, Murgia A, Scienza R: Neurosurgical treatment of von Hippel-Lindau-associated hemangioblastomas: benefits, risks and outcome. J Neurosurg Sci; 2008 Jun;52(2):29-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The authors evaluated 20 VHL subjects (7 males and 13 females, age at surgery 32+/-10 years) who underwent 28 operations in order to remove 48 CNS hemangioblastomas and 1 endolymphatic sac tumor.
  • Among the 49 resected lesions, 21 (42%) were cerebellar, 9 (18%) at brainstem, 19 (38%) spinal (7 cervical, 6 dorsal, 6 at cone-cauda level), and 1 (2%) endolymphatic sac tumor in the petrous bone.
  • CONCLUSION: VHL-associated hemangioblastomas generally affect a young adult population and can be successfully removed, either when symptomatic, or when they reach a critical volume.
  • Transient surgical complications are possible, particularly with brainstem and spinal cord hemangioblastomas.
  • [MeSH-minor] Adult. Endolymphatic Sac / pathology. Endolymphatic Sac / surgery. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Postoperative Complications / epidemiology. Risk Assessment. Treatment Outcome

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  • (PMID = 18500215.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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85. Wakabayashi T, Natsume A, Hatano H, Fujii M, Shimato S, Ito M, Ohno M, Ito S, Ogura M, Yoshida J: p16 promoter methylation in the serum as a basis for the molecular diagnosis of gliomas. Neurosurgery; 2009 Mar;64(3):455-61; discussion 461-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Deoxyribonucleic acid (DNA) methylation of tumor origin can be detected in the serum/plasma of cancer patients.
  • The aim of this study was to detect aberrant p16 promoter methylation as a potential diagnostic marker in the serum of patients with diffuse glioma to differentiate between gliomas and, particularly, to differentiate those in the brainstem from others; this was done by using the modified methylation-specific polymerase chain reaction technique.
  • In addition, the serum DNA in 7 patients with a brainstem tumor (4 gliomas, 1 schwannoma, 1 cavernous angioma, and 1 ependymoma) was analyzed.
  • Similar methylations were detected in the serum of 9 (75%) of the 12 patients with aberrant methylation in the tumor tissues.
  • Additionally, p16 promoter methylation in the serum was observed in all brainstem astrocytoma cases, but not in other cases.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / blood. DNA, Neoplasm / genetics. Genes, p16. Glioma / diagnosis. Glioma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. DNA Methylation / genetics. Female. Genetic Predisposition to Disease / genetics. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 19240607.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm
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86. Colletti V, Shannon R, Carner M, Sacchetto L, Turazzi S, Masotto B, Colletti L: The first successful case of hearing produced by electrical stimulation of the human midbrain. Otol Neurotol; 2007 Jan;28(1):39-43
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  • HYPOTHESIS: Electrical stimulation of the inferior colliculus in the midbrain can provide a safe and efficacious alternative to auditory brainstem implants (ABIs).
  • Some ABI patients without NF2 can achieve excellent speech understanding, suggesting that the limited NF2 performance is due to brainstem damage from the tumor and its removal.
  • CONCLUSION: This approach may provide advantages for patients with brainstem damage.
  • [MeSH-major] Auditory Brain Stem Implantation. Inferior Colliculi / surgery. Speech Perception / physiology
  • [MeSH-minor] Adult. Auditory Cortex / physiology. Auditory Threshold / physiology. Deafness / surgery. Electric Stimulation / instrumentation. Electrodes, Implanted. Humans. Male. Neurofibromatosis 2. Time Factors. Treatment Outcome

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  • (PMID = 17195744.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / N01-DC-4-0005
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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87. Benesch M, Lackner H, Sovinz P, Suppan E, Schwinger W, Eder HG, Dornbusch HJ, Moser A, Triebl-Roth K, Urban C: Late sequela after treatment of childhood low-grade gliomas: a retrospective analysis of 69 long-term survivors treated between 1983 and 2003. J Neurooncol; 2006 Jun;78(2):199-205
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  • Eighty-seven patients with low-grade gliomas grouped according to tumor location (cerebellum: n=28; cerebral hemispheres: n=21; central midline: n=15; brainstem: n=12; tectum: n=5; other locations: n=6) were evaluated for tumor- and/or treatment-related late effects by analysis of medical and computer records, and personal interviews.
  • Median follow-up of survivors is 96 months with an overall survival of 79% (cerebellum: 89%; cerebral hemispheres: 95%; central midline: 80%; brainstem: 25%; tectum: 100%; other locations: 66%).
  • Chronic medical problems (mild ataxia to multiple severe neuroendocrine deficits) are observed in 100% of patients with brainstem/central midline tumors and in 40-50% of patients with low-grade gliomas of other locations.
  • Tumor- and treatment-related late effects are common in patients with low-grade gliomas with the most severe occurring in patients with brainstem or central midline tumors.
  • As long-term survival is excellent in patients with low-grade gliomas except for tumors located in the brainstem, future treatment studies should focus on avoiding long-term late effects.
  • [MeSH-major] Brain Neoplasms / therapy. Endocrine System Diseases / epidemiology. Glioma / therapy. Nervous System Diseases / epidemiology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / adverse effects. Austria / epidemiology. Child. Child, Preschool. Cohort Studies. Combined Modality Therapy / adverse effects. Disease-Free Survival. Female. Follow-Up Studies. Hearing Disorders / epidemiology. Hearing Disorders / etiology. Humans. Infant. Male. Radiation Injuries / epidemiology. Retrospective Studies. Survivors / statistics & numerical data. Vision Disorders / epidemiology. Vision Disorders / etiology

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  • (PMID = 16739030.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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88. Weber DC, Miller RC, Villà S, Hanssens P, Baumert BG, Castadot P, Varlet P, Abacioglu U, Igdem S, Szutowicz E, Nishioka H, Hofer S, Rutz HP, Ozsahin M, Taghian A, Mirimanoff RO: Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network. Int J Radiat Oncol Biol Phys; 2006 Sep 1;66(1):179-86
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  • METHODS AND MATERIALS: Data from a series of 45 adult patients with cerebellar GBM were collected in a retrospective multicenter study.
  • Brainstem invasion was observed in 9 (20%) patients.
  • RESULTS: The 1-year and 2-year actuarial overall survival rate was 37.8% and 14.7%, respectively, and was significantly influenced by salvage treatment (p = 0.048), tumor volume (p = 0.044), extent of neurosurgical resection (p = 0.019), brainstem invasion (p = 0.0013), additional treatment after surgery (p < 0.001), and completion of the initial treatment (p < 0.001) on univariate analysis.
  • The 1- and 2-year actuarial progression free survival was 25% and 10.7%, respectively, and was significantly influenced by brainstem invasion (p = 0.002), additional treatment after surgery (p = 0.0016), and completion of the initial treatment (p < 0.001).
  • On multivariate analysis, survival was negatively influenced by the extent of surgery (p = 0.03) and brainstem invasion (p = 0.02).
  • Brainstem invasion was observed in a substantial number of patients and was an adverse prognostic factor.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy / methods. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 16814953.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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89. Hasegawa T, Kida Y, Yoshimoto M, Koike J: Trigeminal schwannomas: results of gamma knife surgery in 37 cases. J Neurosurg; 2007 Jan;106(1):18-23
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  • The authors evaluated tumor control and functional outcomes in patients who underwent GKS for trigeminal schwannomas to clarify the efficacy of this treatment.
  • The mean tumor volume in these patients was 10 cm3.
  • The mean maximum radiation dose directed to the tumor was 27.9 Gy and the mean dose directed to the tumor margin was 14.2 Gy.
  • In four patients (11%) there was complete tumor remission; in 20 (54%) there was partial tumor remission; in eight (22%) the disease remained stable; and in five (14%) the tumor enlarged or uncontrollable facial pain developed with radiation-induced edema requiring resection.
  • The actuarial 5- and 10-year tumor control rates were both 84%.
  • With respect to functional outcomes, 40% of patients noted an improvement in their symptoms, and one patient experienced new symptoms despite good tumor control.
  • Large tumors that compress the brainstem and cause deviation of the fourth ventricle should first be removed surgically and any remnant should be treated by GKS.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Pain / etiology. Facial Pain / prevention & control. Female. Follow-Up Studies. Humans. Hypesthesia / etiology. Hypesthesia / prevention & control. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17236483.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Toyooka T, Miyazawa T, Fukui S, Otani N, Nawashiro H, Shima K: Central neurogenic hyperventilation in a conscious man with CSF dissemination from a pineal glioblastoma. J Clin Neurosci; 2005 Sep;12(7):834-7
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  • He had tumor dissemination to the brainstem 10 months after undergoing partial removal of a pineal glioblastoma.
  • To the best of our knowledge, this is the first report of CNH caused by the cerebrospinal fluid dissemination of a tumor.
  • The authors suggest that multiple lesions from an infiltrative tumor in the brainstem may give rise to CNH and further our understanding of the pathogenesis of CNH.
  • [MeSH-minor] Adult. Disease Progression. Humans. Magnetic Resonance Imaging / methods. Male. Neoplasm Invasiveness

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  • (PMID = 16198924.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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91. Park HY, Kim SH, Son EJ, Lee HK, Lee WS: Intracanalicular facial nerve schwannoma. Otol Neurotol; 2007 Apr;28(3):376-80
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  • INTERVENTIONS: Pure-tone average, auditory brainstem response, caloric test, and temporal magnetic resonance imaging were done in all 11 patients.
  • MAIN OUTCOME MEASURE: Preoperative symptoms, pure-tone average, auditory brainstem response, caloric test, electroneuronography, and magnetic resonance imaging were compared between patients with facial nerve schwannomas and patients with vestibular schwannomas.
  • CONCLUSION: A facial nerve schwannoma may be misdiagnosed as a vestibular schwannoma, especially when the tumor is confined to the internal auditory canal.
  • [MeSH-minor] Adult. Aged. Audiometry, Pure-Tone. Diagnosis, Differential. Ear, Inner. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neuroma, Acoustic / pathology. Otologic Surgical Procedures. Retrospective Studies

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  • (PMID = 17414044.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Yu LM, Yang SM, Han DY, Yu LM, Yang WY: [Preliminary study of intraoperative auditory monitoring techniques in acoustic neuroma surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 May;41(5):335-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Continuous hearing monitoring of auditory brainstem responses (ABR) and transtympanic electrocochleography (ECochG) was performed during operation.
  • The hearing was preserved in 2 cases, which had class A hearing post operation with tumor size <2 cm.
  • In another case, the waves of I, III could be evoked after the tumor resection with the disappearance of wave V.
  • The CAP amplitudes decreased significantly in 4 cases and even dropped to zero while dissecting the tumor at the lateral end of the internal auditory canal (IAC) or clamping the internal auditory artery (IAA) during operation.
  • In one case, although the cochlear nerve was cut down, the CAP could still be recorded after the tumor resection.
  • However, the CAP amplitudes was dropped to zero while pressurized and pulled cochlea nerve of brainstem lateral and the wave disappeared post-operation in another cases.
  • One of them showed low amplitude of CAP wave when the tumor partially removed.
  • Drilling of the IAC and tumor removal at the lateral end of the IAC were the most critical steps for achieving hearing preservation.
  • [MeSH-minor] Adolescent. Adult. Audiometry, Evoked Response. Evoked Potentials, Auditory, Brain Stem. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 16848284.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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93. Korah MP, Esiashvili N, Mazewski CM, Hudgins RJ, Tighiouart M, Janss AJ, Schwaibold FP, Crocker IR, Curran WJ Jr, Marcus RB Jr: Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma. Int J Radiat Oncol Biol Phys; 2010 May 1;77(1):106-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Five patients had <1.5-cm(2) residual tumor, 4 had >or=1.5-cm(2) residual tumor, and the remainder had no residual tumor.
  • On univariate analysis, brainstem invasion, midline tumor location, younger age, and the absence of radiographic residual tumor were found to be predictors of PFS; the last two variables remained significant on multivariate analysis.
  • From 1990 to 2000 and from 2001 to 2007, the proportions of patients with no radiographic residual tumor were 77% and 94%, respectively.
  • Children with midline tumors exhibiting brainstem invasion are at increased risk.
  • With the increased incidence of PFS and the permanent morbidity in many patients, the risks and benefits of complete tumor removal in all patients need to be reexamined.
  • [MeSH-minor] Adolescent. Analysis of Variance. Ataxia / epidemiology. Ataxia / etiology. Child. Child, Preschool. Combined Modality Therapy / methods. Cranial Irradiation. Disease-Free Survival. Dysarthria / epidemiology. Dysarthria / etiology. Female. Follow-Up Studies. Humans. Incidence. Male. Muscle Hypotonia / epidemiology. Muscle Hypotonia / etiology. Mutism / epidemiology. Mutism / etiology. Neoplasm, Residual. Postoperative Complications / epidemiology. Radiotherapy Dosage. Retrospective Studies. Risk. Syndrome. Young Adult

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  • (PMID = 19695790.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Goto T, Ohata K, Morino M, Takami T, Tsuyuguchi N, Nishio A, Hara M: Falcotentorial meningioma: surgical outcome in 14 patients. J Neurosurg; 2006 Jan;104(1):47-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On the basis of neuroimaging studies, the authors analyzed the influence of the anatomical relationship of the tumor to the vein of Galen, patency of the vein of Galen, tumor size, and the signal intensities on the magnetic resonance images to determine possible difficulties that might be encountered during surgery and to prognosticate the outcome of surgery.
  • Of the prognostic factors, tumor location especially seemed to be the most important (p < 0.01, Fisher exact test).
  • The outcome associated with the inferior type of tumor was significantly less optimal probably due to the relationship to the deep veins and the brainstem.
  • Classification of the tumor location by preoperative neuroimaging studies can be helpful in estimating the surgical difficulty that might be encountered in treating the falcotentorial junction meningioma.
  • [MeSH-minor] Adult. Aged. Cerebral Veins / surgery. Female. Humans. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 16509146.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Ares C, Hug EB, Lomax AJ, Bolsi A, Timmermann B, Rutz HP, Schuller JC, Pedroni E, Goitein G: Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys; 2009 Nov 15;75(4):1111-8
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  • Brainstem compression at the time of PT (p = 0.007) and gross tumor volume >25 mL (p = 0.03) were associated with lower LC rates.
  • No patient experienced brainstem toxicity.
  • With target definition, dose prescription and normal organ tolerance levels similar to passive-scattering based PT series, complication-free, tumor control and survival rates are at present comparable.
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Child. Female. Follow-Up Studies. Humans. Male. Maximum Tolerated Dose. Middle Aged. Neoplasm, Residual. Radiotherapy Dosage. Relative Biological Effectiveness. Survival Rate. Tumor Burden. Young Adult

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  • (PMID = 19386442.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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96. Matsumoto H, Ugawa Y: [Paraneoplastic opsoclonus-myoclonus syndrome--a review]. Brain Nerve; 2010 Apr;62(4):365-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Parainfectious brainstem encephalitis, toxic-metabolic disturbances and others condition should be considered as potential causes of these symptoms.
  • In adults, POMS is less responsive to immunotherapy and improves only with tumor resection.
  • [MeSH-minor] Adrenocorticotropic Hormone / therapeutic use. Adult. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Child. Cyclophosphamide / therapeutic use. Humans. Immunity, Cellular. Immunity, Humoral. Immunoglobulins, Intravenous / therapeutic use. Immunotherapy. Plasma Exchange. Prognosis. Rituximab

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  • (PMID = 20420176.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Autoantibodies; 0 / Immunoglobulins, Intravenous; 4F4X42SYQ6 / Rituximab; 8N3DW7272P / Cyclophosphamide; 9002-60-2 / Adrenocorticotropic Hormone
  • [Number-of-references] 22
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97. Brandt MG, Poirier J, Hughes B, Lownie SP, Parnes LS: The transcrusal approach: a 10-year experience at one Canadian center. Neurosurgery; 2010 May;66(5):1017-22
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  • METHODS: Ten-year retrospective review of 17 consecutive patients requiring transcrusal exposure of the petrous apex and upper brainstem was performed.
  • Average tumor size was 3.6 cm.
  • Two patients died perioperatively (brainstem infarction).
  • [MeSH-major] Brain Diseases / surgery. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Postoperative Complications / epidemiology
  • [MeSH-minor] Adult. Aged. Canada. Female. Hearing Loss / epidemiology. Hearing Loss / etiology. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20414979.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Strauss C, Bischoff B, Romstöck J, Rachinger J, Rampp S, Prell J: Hearing preservation in medial vestibular schwannomas. J Neurosurg; 2008 Jul;109(1):70-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A consecutive series of 31 cases in 30 patients with medial VSs (mean size 31 mm) who underwent surgery between 1997 and 2005 via a suboccipitolateral route was evaluated with respect to pre- and postoperative cochlear nerve function, extent of tumor removal, and radiological findings.
  • Intraoperative monitoring of brainstem auditory evoked potentials was performed in all patients with hearing.
  • Tumor removal was complete in all patients with hearing preservation, except for 2 patients with neurofibromatosis.
  • In 1 patient a recurrent tumor was completely removed 3 years after the initial procedure.
  • Even in large tumors, hearing could be preserved in 37% of cases, since the cochlear nerve in medial schwannomas may not exhibit the adherence to the tumor capsule seen in tumors with comparable size involving the internal auditory canal.
  • [MeSH-minor] Adult. Aged. Cochlear Nerve / physiopathology. Cohort Studies. Facial Nerve / physiopathology. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Recovery of Function / physiology. Treatment Outcome

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  • (PMID = 18590434.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Kurokawa R, Kawase T: Spinal arachnoid cyst causing paraplegia following skull base surgery. Neurol Med Chir (Tokyo); 2006 Jun;46(6):309-12
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  • A 40-year-old woman presented with a right petroclival meningioma compressing the brainstem and manifesting as a 6-month history of headache and gait difficulty.
  • The patient underwent subtotal removal of the tumor via an anterior transpetrosal approach.
  • Magnetic resonance (MR) imaging of the brain showed enlargement of the ventricles and no residual brainstem compression.
  • The patient's gait gradually deteriorated, although repeat brain MR imaging showed no significant increase in ventricular size.
  • [MeSH-minor] Adult. Cerebrospinal Fluid Shunts. Decompression, Surgical. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hydrocephalus / diagnosis. Hydrocephalus / surgery. Laminectomy. Magnetic Resonance Imaging. Neoplasm, Residual / diagnosis. Neurologic Examination. Recurrence. Reoperation. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery

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  • (PMID = 16794354.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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100. Noshita N, Kumabe T, Kayama T, Tominaga T: [Choroid plexus tumors: report of 7 cases in a single institution]. No Shinkei Geka; 2006 Jan;34(1):73-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Subtotal resection was achieved in four patients, one of whom underwent second surgery resulting in total resection, and one patient died of respiratory disturbance after the third operation because of regrowth of the tumor.
  • Complete excision could not be achieved in 3 of the 5 tumors located in the fourth ventricle because of extension to the brainstem.
  • [MeSH-minor] Adult. Child, Preschool. Female. Humans. Infant. Magnetic Resonance Imaging. Male

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  • (PMID = 16440700.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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