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1. Tanaka K, Sasayama T, Kawamura A, Kondoh T, Kanomata N, Kohmura E: Isolated oculomotor nerve paresis in anaplastic astrocytoma with exophytic invasion. Neurol Med Chir (Tokyo); 2006 Apr;46(4):198-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated oculomotor nerve paresis in anaplastic astrocytoma with exophytic invasion.
  • Computed tomography and magnetic resonance imaging showed an intra-axial tumor in the left temporal lobe, extending to the basal and prepontine cisterns, and compressing the brainstem.
  • The histological diagnosis was anaplastic astrocytoma.
  • [MeSH-major] Astrocytoma / complications. Oculomotor Nerve Diseases / etiology. Supratentorial Neoplasms / complications. Temporal Lobe
  • [MeSH-minor] Adult. Astrocytes / pathology. Biomarkers, Tumor / analysis. Brain Stem / pathology. Cerebral Arteries / pathology. Cisterna Magna / pathology. Dominance, Cerebral / physiology. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology. Nerve Compression Syndromes / diagnosis. Nerve Compression Syndromes / etiology. Nerve Compression Syndromes / pathology. Nerve Compression Syndromes / surgery. Neuronavigation. Oculomotor Nerve / pathology. Oculomotor Nerve / surgery. Pons / pathology

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  • (PMID = 16636512.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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2. Pareés I, Alonso J, Rovira A, Martínez E, Montalban X: [Diffuse astrocytoma presenting as an optic-spinal syndrome]. Rev Neurol; 2009 Apr 1-15;48(7):354-6
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  • [Title] [Diffuse astrocytoma presenting as an optic-spinal syndrome].
  • A patient with an optic-spinal syndrome due to a fibrillary astrocytoma is described.
  • Brain MRI showed no abnormalities, and spinal MRI disclosed a cervical cord lesion suggestive of myelitis.
  • A new MRI with spectroscopy revealed an infiltrative lesion involving the right frontal lobe, optic chiasm, internal capsule, brainstem and cervical spinal cord, which was suggestive of low-grade astrocytoma.
  • Brain biopsy confirmed the diagnosis of diffuse fibrillary astrocytoma.
  • Brain biopsy is often necessary for a definite diagnosis.
  • [MeSH-major] Astrocytoma. Demyelinating Diseases. Optic Neuritis. Spinal Cord / pathology
  • [MeSH-minor] Adult. Biopsy. Brain / pathology. Humans. Male. Oligoclonal Bands / cerebrospinal fluid. Syndrome

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  • (PMID = 19319816.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Oligoclonal Bands
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3. Cao Z, Lv J, Wei X, Quan W: Appliance of preoperative diffusion tensor imaging and fiber tractography in patients with brainstem lesions. Neurol India; 2010 Nov-Dec;58(6):886-90
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  • [Title] Appliance of preoperative diffusion tensor imaging and fiber tractography in patients with brainstem lesions.
  • BACKGROUND: Surgical resection of brainstem lesions has a high risk of morbidity, because vital fasciculi in the brainstem can be damaged along the entry routes.
  • Diffusion tensor imaging (DTI) is an in vivo method for mapping white matter fiber tracts in the brain.
  • OBJECTIVE: To summarize the experience of surgical treatment of brainstem lesions with the assistance of DTI and fiber tractography.
  • MATERIALS AND METHODS: A retrospective analysis clinical data of nine patients with brainstem lesions were investigated between July 2007 and September 2009.
  • Total resection was achieved in two patients with brainstem cavernomas and two patients with pilocytic astrocytoma.
  • The neurological functional status was better than preoperative period in eight patients, one patient with medulla oblongata astrocytoma deteriorated.
  • CONCLUSIONS: DTI and fiber tractography can provide valuable information regarding the relationship between the principal fiber tracts and brainstem lesions, which is useful in neurosurgical planning.
  • [MeSH-major] Brain Diseases / diagnosis. Brain Mapping. Brain Stem / pathology. Diffusion Tensor Imaging. Pyramidal Tracts / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Imaging, Three-Dimensional. Male. Neurosurgery / methods. Preoperative Care. Retrospective Studies. Young Adult

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  • (PMID = 21150055.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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4. Tibbetts KM, Emnett RJ, Gao F, Perry A, Gutmann DH, Leonard JR: Histopathologic predictors of pilocytic astrocytoma event-free survival. Acta Neuropathol; 2009 Jun;117(6):657-65
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  • [Title] Histopathologic predictors of pilocytic astrocytoma event-free survival.
  • Pilocytic astrocytoma (PA) is the most common pediatric brain tumor.
  • Most arise in the cerebellum, but they also can develop in the brainstem and optic nerve, where gross total resection (GTR) is not possible.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Brain / pathology. Brain / physiopathology. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Immunohistochemistry. Infant. Male. Mitotic Index. Retrospective Studies. Signal Transduction. Tumor Suppressor Protein p53 / metabolism. Young Adult


5. Ramírez-Zamora A, Biller J: Brainstem cavernous malformations: a review with two case reports. Arq Neuropsiquiatr; 2009 Sep;67(3B):917-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brainstem cavernous malformations: a review with two case reports.
  • We present one case of 'de novo' brainstem cavernous malformation after radiation therapy adding to the increasing number of reported cases in the medical literature, and the case of a pregnant patient with symptomatic intracranial hemorrhage related to brainstem CMs to illustrate the complex nature in management of these patients, followed by a review of clinical and radiographic characteristics.
  • [MeSH-major] Brain Stem. Cerebral Hemorrhage / etiology. Intracranial Arteriovenous Malformations / diagnosis. Pregnancy Complications, Cardiovascular / diagnosis
  • [MeSH-minor] Adult. Astrocytoma / radiotherapy. Cerebellar Neoplasms / radiotherapy. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Pregnancy. Radiotherapy / adverse effects

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  • (PMID = 19838533.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 40
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6. Berhouma M, Jemel H, Kchir N: Calcified pilocytic astrocytoma of the medulla mimicking a brainstem "stone". Pathologica; 2008 Oct;100(5):408-10
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  • [Title] Calcified pilocytic astrocytoma of the medulla mimicking a brainstem "stone".
  • Brainstem gliomas are a heterogeneous group of tumours commonly found in children, comprising about 10% of central nervous system tumours in paediatric patients, but less than 2% in adults.
  • Thin calcifications can be normally found within low grade gliomas, but densely calcified pilocytic astrocytomas of the brainstem have been only rarely reported.
  • We present the case of a young man presenting with a large brainstem calcification involving the medulla, which was subtotally resected using a posterior suboccipital approach.
  • The definitive pathological diagnosis was calcified pilocytic astrocytoma.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Stem Neoplasms / diagnosis. Calcinosis / diagnosis. Medulla Oblongata / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Gait Ataxia / etiology. Humans. Male

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  • (PMID = 19253601.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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7. Stüer C, Vilz B, Majores M, Becker A, Schramm J, Simon M: Frequent recurrence and progression in pilocytic astrocytoma in adults. Cancer; 2007 Dec 15;110(12):2799-808
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  • [Title] Frequent recurrence and progression in pilocytic astrocytoma in adults.
  • BACKGROUND: Most pilocytic astrocytomas (piloA) are benign growths (World Health Organization [WHO] grade 1) of the deep midline structures, the brainstem, and the cerebellum.
  • RESULTS: There were 20 patients (45%) with supratentorial lobar piloA (including 10 temporal/temporomesial tumors, 5 parietal tumors, 3 insular tumors, 1 frontal tumor, and 1 occipital tumors), 12 patients with cerebellar piloA, 7 patients with brainstem piloA, 2 patients with opticochiasmatic PiloA, 1 patient with intramedullary piloA, and 2 patients with piloA of the basal ganglia.
  • CONCLUSIONS: PiloA in adult patients, surprisingly, often was not a benign disease.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / radiography. Brain Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Prognosis. Recurrence. Treatment Outcome

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  • [CommentIn] Nat Clin Pract Neurol. 2008 Jun;4(6):296-7 [18414467.001]
  • (PMID = 17973253.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Sajadi A, Janzer RC, Lu TL, Duff JM: Pilomyxoid astrocytoma of the spinal cord in an adult. Acta Neurochir (Wien); 2008 Jul;150(7):729-31

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  • [Title] Pilomyxoid astrocytoma of the spinal cord in an adult.
  • We report a 45-year old woman with a pilomyxoid astrocytoma (PMA) of the cervical spinal cord with a rapid clinical course and fatal outcome.
  • Moreover, two family members of the patient were reported to have brainstem tumours with similar histopathological features.
  • [MeSH-major] Astrocytoma / genetics. Spinal Cord Neoplasms / genetics

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  • (PMID = 18536992.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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9. Salgado JV, Costa-Silva M, Malloy-Diniz LF, Siqueira JM, Teixeira AL: Prefrontal cognitive dysfunction following brainstem lesion. Clin Neurol Neurosurg; 2007 May;109(4):379-82
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  • [Title] Prefrontal cognitive dysfunction following brainstem lesion.
  • As ascending monoaminergic brainstem systems modulate PFC functioning, it is possible that lesions in the brainstem lead to symptoms similar to prefrontal dysfunction.
  • A 29-year-old man developed several cognitive and behavioral symptoms after neurosurgery for resection of a pilocytic astrocytoma in the pontine-mesencephalic area.
  • A careful analysis of symptoms indicated PFC dysfunction that could be attributed to lesions in the ascending monoaminergic brainstem systems.
  • This is a unique case of PFC dysfunction that may be related to post-operative lesion of the catecholaminergic nuclei in the brainstem.
  • [MeSH-major] Astrocytoma / surgery. Brain Stem Neoplasms / surgery. Cognition Disorders / physiopathology. Postoperative Complications / physiopathology. Prefrontal Cortex / physiopathology
  • [MeSH-minor] Adolescent. Adult. Attention / drug effects. Attention / physiology. Central Nervous System Stimulants / therapeutic use. Educational Status. Follow-Up Studies. Humans. Impulsive Behavior / diagnosis. Impulsive Behavior / drug therapy. Impulsive Behavior / physiopathology. Inhibition (Psychology). Interpersonal Relations. Learning Disorders / diagnosis. Learning Disorders / drug therapy. Learning Disorders / physiopathology. Male. Methylphenidate / therapeutic use. Neuropsychological Tests. Problem Solving / drug effects. Problem Solving / physiology

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  • (PMID = 17275997.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Central Nervous System Stimulants; 207ZZ9QZ49 / Methylphenidate
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10. Miki T, Nakajima N, Akimoto J, Wada J, Haraoka J: Neuroendoscopic trans-third ventricle approach for lesions of the ventral brainstem surface. Minim Invasive Neurosurg; 2008 Dec;51(6):313-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendoscopic trans-third ventricle approach for lesions of the ventral brainstem surface.
  • Due to the establishment in recent years of neuroendoscopic third ventriculostomy (ETV), it has become possible during ETV to observe the ventral brainstem surface--particularly the prepontine cistern--in a minimally invasive manner via the third ventricular base with a neuroendoscope.
  • As an adaptation of that technique in this study, we investigated a neuroendoscopic trans-third ventricle approach (ETTVA), which accesses lesions of the ventral brainstem surface with a neuroendoscope inserted via the stoma of the third ventricular floor.
  • Our study included 6 cases, including one case each of neurenteric cyst, chordoma, pontine glioma (astrocytoma), ecchordosis physaliphora, endodermal cyst, and cystic schwannoma.
  • [MeSH-major] Astrocytoma / surgery. Brain Stem Neoplasms / surgery. Chordoma / surgery. Minimally Invasive Surgical Procedures / methods. Neuroendoscopy / methods. Third Ventricle / surgery. Ventriculostomy / methods
  • [MeSH-minor] Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19061139.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Sharma MS, Kondziolka D, Khan A, Kano H, Niranjan A, Flickinger JC, Lunsford LD: Radiation tolerance limits of the brainstem. Neurosurgery; 2008 Oct;63(4):728-32; discussion 732-3
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  • [Title] Radiation tolerance limits of the brainstem.
  • OBJECTIVE: One of the key limitations of gamma knife surgery arises from the radiation safety tolerance limit of the brainstem.
  • The authors conducted an analysis of patients with intra-axial brainstem lesions and documented the incidence of adverse radiation imaging effects (ARIE) and new neurological deficits after gamma knife surgery.
  • METHODS: Thirty-eight patients (39 lesions) with intra-axial brainstem astrocytomas or vascular malformations underwent gamma knife surgery during a 6-year interval.
  • Brainstem exposure volume was calculated by subtracting the volume within the 12-Gy isodose line (12 Gray volume) from the prescription volume.
  • RESULTS: The average prescription volume was 1.46 cm, 12 Gy volume was 2.03 cm, and brainstem exposure volume was 0.57 cm.
  • CONCLUSION: Exposure of the brainstem to more than 12 Gy at volumes as low as 0.1 cm can produce ARIE and new neurological deficits.
  • The tolerance of the brainstem to radiosurgery is related to patient age, lesion volume, and pathology.
  • Analysis of the exposed volume of brainstem tissue may be useful in radiosurgical planning for individual patients.
  • [MeSH-major] Astrocytoma / surgery. Brain Stem / radiation effects. Brain Stem Neoplasms / surgery. Ganglioglioma / surgery. Nervous System Diseases / etiology. Radiation Injuries / etiology. Radiosurgery / adverse effects
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Child, Preschool. Dose-Response Relationship, Radiation. Female. Humans. Intracranial Arteriovenous Malformations / surgery. Male. Middle Aged. Retrospective Studies. Time Factors. Young Adult

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  • (PMID = 18981883.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Ramat S, Leigh RJ, Zee DS, Optican LM: Ocular oscillations generated by coupling of brainstem excitatory and inhibitory saccadic burst neurons. Exp Brain Res; 2005 Jan;160(1):89-106
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  • [Title] Ocular oscillations generated by coupling of brainstem excitatory and inhibitory saccadic burst neurons.
  • Previous models proposed that high-frequency eye oscillations produced by the saccadic system (saccadic oscillations), occur because of a delay in a negative feedback loop around high-gain, excitatory burst neurons in the brainstem.
  • We propose another model that accounts for saccadic oscillations based on 1) coupling of excitatory and inhibitory burst neurons in the brainstem and 2) the hypothesis that burst neurons show post-inhibitory rebound discharge.
  • [MeSH-major] Astrocytoma / physiopathology. Biological Clocks / physiology. Brain Stem / physiology. Cerebellar Neoplasms / physiopathology. Cerebellar Nuclei / physiology. Neurons / physiology. Saccades / physiology
  • [MeSH-minor] Adult. Feedback / physiology. Humans. Male. Middle Aged. Models, Neurological. Nerve Net / physiology. Nerve Net / physiopathology. Neural Inhibition / physiology. Neural Pathways / physiology. Neural Pathways / physiopathology. Ocular Motility Disorders / etiology. Ocular Motility Disorders / physiopathology. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Psychomotor Performance / physiology

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  • (PMID = 15289966.001).
  • [ISSN] 0014-4819
  • [Journal-full-title] Experimental brain research
  • [ISO-abbreviation] Exp Brain Res
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY01849; United States / NEI NIH HHS / EY / EY06717
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Germany
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13. Chen X, Weigel D, Ganslandt O, Buchfelder M, Nimsky C: Diffusion tensor imaging and white matter tractography in patients with brainstem lesions. Acta Neurochir (Wien); 2007 Nov;149(11):1117-31; discussion 1131

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion tensor imaging and white matter tractography in patients with brainstem lesions.
  • BACKGROUND: Diffusion tensor imaging (DTI) and white matter tractography (WMT) are promising techniques for estimating the course, extent, and connectivity patterns of the white matter (WM) structures in the human brain.
  • In this study, we investigated the ability of DTI and WMT to visualize white matter tract involvement for the preoperative surgical planning and postoperative assessment of brainstem lesions.
  • METHODS: Preoperative and postoperative DTI data (echo-planar, 1.5T) were retrospectively analyzed in 10 patients with brainstem lesions (3 diffuse, 7 focal).
  • CONCLUSIONS: Compared with the information provided by conventional MR imaging, DTI and WMT provided superior quantification and visualization of lesion involvement in eloquent fibre tracts of the brainstem.
  • Moreover, DTI and WMT were found to be beneficial for white matter recognition in the neurosurgical planning and postoperative assessment of brainstem lesions.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Mapping. Brain Stem Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging. Hemangioma, Cavernous, Central Nervous System / diagnosis. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Nerve Fibers, Myelinated / pathology. Nerve Net / pathology. Neuronavigation. Pons / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Damage, Chronic / diagnosis. Brain Damage, Chronic / pathology. Brain Damage, Chronic / surgery. Cranial Nerve Diseases / diagnosis. Cranial Nerve Diseases / pathology. Dominance, Cerebral / physiology. Female. Humans. Male. Middle Aged. Neurologic Examination. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Pyramidal Tracts / pathology. Pyramidal Tracts / surgery

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  • (PMID = 17712509.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
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14. Mursch K, Halatsch ME, Markakis E, Behnke-Mursch J: Intrinsic brainstem tumours in adults: results of microneurosurgical treatment of 16 consecutive patients. Br J Neurosurg; 2005 Apr;19(2):128-36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrinsic brainstem tumours in adults: results of microneurosurgical treatment of 16 consecutive patients.
  • Intrinsic brainstem tumours in adults have a poor prognosis and surgical resection is rarely performed.
  • Eight patients had from WHO grade II astrocytoma and a similar course as patients with higher-grade gliomas (n = 4).
  • Our results indicate that open microneurosurgery for intrinsic brainstem tumours is of questionable benefit for the patient.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Glioma / surgery. Microsurgery / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / diagnosis. Astrocytoma / mortality. Astrocytoma / surgery. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Survival Analysis. Treatment Outcome

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  • (PMID = 16120515.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Yen CP, Sheehan J, Steiner M, Patterson G, Steiner L: Gamma knife surgery for focal brainstem gliomas. J Neurosurg; 2007 Jan;106(1):8-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife surgery for focal brainstem gliomas.
  • OBJECT: Focal tumors, a distinct subgroup of which is composed of brainstem gliomas, may have an indolent clinical course.
  • In the present study the authors assess clinical and imaging results in 20 patients who harbored focal brainstem gliomas treated with GKS between 1990 and 2001.
  • In 10 cases a tumor specimen was obtained either by open surgery or stereotactic biopsy, securing the diagnosis of pilocytic astrocytoma in five patients and nonpilocytic astrocytoma in five others.
  • CONCLUSIONS: Gamma Knife surgery may be an effective primary treatment or adjunct to open surgery for focal brainstem gliomas.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Glioma / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome. Tumor Burden

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  • [CommentIn] J Neurosurg. 2007 Sep;107(3):708; author reply 708-9 [17886574.001]
  • [CommentIn] J Neurosurg. 2007 Jan;106(1):6-7 [17262931.001]
  • (PMID = 17236482.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Rachinger W, Grau S, Holtmannspötter M, Herms J, Tonn JC, Kreth FW: Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only. J Neurol Neurosurg Psychiatry; 2009 Oct;80(10):1134-9
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  • [Title] Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only.
  • OBJECTIVE: The aim of the current prospective study was to analyse the validity of MRI based diagnosis of brainstem gliomas which was verified by stereotactic biopsy and follow-up evaluation as well as to assess prognostic factors and risk profile.
  • METHODS: Between 1998 and 2007, all consecutive adult patients with radiologically suspected brainstem glioma were included.
  • RESULTS: 46 adult patients were included.
  • Histological evaluation revealed pilocytic astrocytoma (n = 2), WHO grade II glioma (n = 14), malignant glioma (n = 12), metastasis (n = 7), lymphoma (n = 5), cavernoma (n = 1), inflammatory disease (n = 2) or no tumour/gliosis (n = 3).
  • In the subgroup with a verified brainstem glioma, negative predictors for length of survival were higher tumour grade (p = 0.002) and Karnofsky performance score < or =70 (p = 0.004).
  • CONCLUSION: Intra-axial brainstem lesions with a radiological pattern of glioma represent a very heterogeneous tumour group with completely different outcomes.
  • [MeSH-major] Biopsy / methods. Brain Stem Neoplasms / pathology. Glioma / pathology. Magnetic Resonance Imaging. Stereotaxic Techniques
  • [MeSH-minor] Adolescent. Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Reproducibility of Results. Retrospective Studies. Risk Factors. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19520698.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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17. Burzynski SR, Janicki TJ, Weaver RA, Burzynski B: Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma. Integr Cancer Ther; 2006 Mar;5(1):40-7
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  • [Title] Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma.
  • BACKGROUND: Brainstem glioma carries the worst prognosis of all malignancies of the brain.
  • Most patients with brainstem glioma fail standard radiation therapy and chemotherapy and do not survive longer than 2 years.
  • RESULTS: The overall survival at 2 and 5 years was 39% and 22%, respectively, and maximum survival was more than 17 years for a patient with anaplastic astrocytoma and more than 5 years for a patient with glioblastoma.
  • CONCLUSION: Antineoplastons contributed to more than a 5-year survival in recurrent diffuse intrinsic glioblastomas and anaplastic astrocytomas of the brainstem in a small group of patients.
  • [MeSH-major] Benzeneacetamides / administration & dosage. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy. Glutamine / analogs & derivatives. Neoplasm Recurrence, Local / drug therapy. Phenylacetates / administration & dosage. Piperidones / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Combinations. Female. Follow-Up Studies. Humans. Injections, Intravenous. Magnetic Resonance Imaging. Male. Maximum Tolerated Dose. Neoplasm Staging. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 16484713.001).
  • [ISSN] 1534-7354
  • [Journal-full-title] Integrative cancer therapies
  • [ISO-abbreviation] Integr Cancer Ther
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzeneacetamides; 0 / Drug Combinations; 0 / Phenylacetates; 0 / Piperidones; 0RH81L854J / Glutamine; 104624-98-8 / antineoplaston AS 2-1; 91531-30-5 / antineoplaston A10
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18. Salmaggi A, Fariselli L, Milanesi I, Lamperti E, Silvani A, Bizzi A, Maccagnano E, Trevisan E, Laguzzi E, Rudà R, Boiardi A, Soffietti R, Associazione Italiana di Neuro-oncologia: Natural history and management of brainstem gliomas in adults. A retrospective Italian study. J Neurol; 2008 Feb;255(2):171-7
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  • [Title] Natural history and management of brainstem gliomas in adults. A retrospective Italian study.
  • Brainstem gliomas in adults are rare tumors, with heterogeneous clinical course; only a few studies in the MRI era describe the features in consistent groups of patients.
  • In this retrospective study, we report clinical features at onset, imaging characteristics and subsequent course in a group of 34 adult patients with either histologically proven or clinico-radiologically diagnosed brainstem gliomas followed at two centers in Northern Italy.
  • In 21 of the patients histology was obtained and in 20 it was informative (2 pilocytic astrocytoma, 9 low-grade astrocytoma, 8 anaplastic astrocytoma and 1 glioblastoma).
  • Compared with literature data, our study confirms the clinical and radiological heterogeneity of adult brainstem gliomas and underscores the need for multicenter trials in order to assess the efficacy of treatments in these tumors.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / therapy. Glioma / pathology. Glioma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Brain / pathology. Disease Progression. Female. Fluorodeoxyglucose F18. Humans. Image Processing, Computer-Assisted. Italy. Magnetic Resonance Imaging. Male. Middle Aged. Positron-Emission Tomography. Prognosis. Radiopharmaceuticals. Retrospective Studies. Spinal Cord / pathology. Survival Analysis. Treatment Outcome

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  • (PMID = 18293027.001).
  • [ISSN] 0340-5354
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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19. Wang CC, Zhang JT, Liu AL: [Surgical management of brain-stem gliomas: a retrospective analysis of 311 cases]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2005 Feb;27(1):7-12

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  • [Title] [Surgical management of brain-stem gliomas: a retrospective analysis of 311 cases].
  • OBJECTIVE: To further study the clinical features, diagnosis, and surgery outcome of brain-stem gliomas.
  • METHODS: Totally 311 patients with brain-stem gliomas received surgery operations in our hospital from 1980 to the end of 2001.
  • RESULTS: Different brain-stem gliomas showed different growth patterns.
  • Five years survival rate is 67% in ependymoma patients, 42% in astrocytoma patients.
  • None of brain-stem glioblastoma patients survived up to 5 years.
  • CONCLUSIONS: The histology and growth pattern of brainstem gliomas varies.
  • The patients with well-differentiated gliomas of brain-stem may be cured by microsurgical removal.
  • [MeSH-major] Astrocytoma / surgery. Brain Stem Neoplasms / surgery. Ependymoma / surgery. Glioblastoma / surgery. Neurosurgical Procedures
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Mesencephalon / surgery. Microsurgery / methods. Middle Aged. Pons / surgery. Retrospective Studies. Survival Rate

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  • (PMID = 15782484.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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20. Battaglia F, Uro-Coste E, Delisle MB, Tannier C: [Radiation-induced cavernoma: two cases]. Rev Neurol (Paris); 2008 May;164(5):468-71
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  • Cavernomas occur several years after radiotherapy for brain neoplasia.
  • The first case was a 55-year-old man given radiation and chemotherapy for frontal astrocytoma at the age of 46.
  • The second concerned a 30-year-old woman treated by radiation and surgery for brainstem medulloblastoma at the age of four.
  • [MeSH-minor] Adult. Astrocytoma / radiotherapy. Cerebellar Neoplasms / radiotherapy. Cerebral Hemorrhage / pathology. Cerebral Ventricles / pathology. Female. Histocytochemistry. Humans. Magnetic Resonance Imaging. Male. Medulloblastoma / radiotherapy. Middle Aged. Pons / pathology

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  • (PMID = 18555880.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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21. Hargrave D: Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy. Br J Neurosurg; 2009 Aug;23(4):351-63
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  • Gliomas are the most common type of paediatric brain tumour and range from benign low grade gliomas which can be resected/observed to aggressive brainstem gliomas with dismal survival rates.
  • Pilocytic astrocytoma, the most common childhood low grade brain tumour, has recently been shown to harbour an activated BRAF/MAPK/ERK pathway in the majority of cases; this represents an attractive target for new agents.
  • The molecular biology of adult malignant glioma is now well described and targeted therapies against VEGFR are already playing a role in the management of glioblastoma.
  • Brainstem glioma remains a tumour with a dismal prognosis but relatively little is known about the underlying biology and progress will require a concerted effort to collect tissue by biopsy and autopsy to allow appropriate analysis to identify and validate targets.
  • [MeSH-major] Brain Neoplasms. Glioma / pathology
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / genetics. Astrocytoma / pathology. Astrocytoma / therapy. Child. Child, Preschool. Combined Modality Therapy. Drug Delivery Systems. Genetic Predisposition to Disease. Genome-Wide Association Study. Hamartoma Syndrome, Multiple / genetics. Humans. Infant. Neoplasm Staging. Neurofibromatosis 1 / genetics. Prognosis. Tuberous Sclerosis / genetics

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  • (PMID = 19637006.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 170
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22. Suzuki Y, Tanaka K, Negishi D, Shimizu M, Yoshida Y, Hashimoto T, Yamazaki H: Pharmacokinetic investigation of increased efficacy against malignant gliomas of carboplatin combined with hyperbaric oxygenation. Neurol Med Chir (Tokyo); 2009 May;49(5):193-7; discussion 197
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  • The efficacy of intravenous administration of 400 mg carboplatin/m(2) body surface area over 60 minutes combined with hyperbaric oxygenation (HBO) therapy (0.2 MPa for 60 min) was investigated in 6 Japanese patients (aged 36-67 years) with malignant or brainstem gliomas.
  • Brain tumor response was evaluated by magnetic resonance imaging as a function of maximum plasma concentration, area under the curve, or mean residence time (MRT) for carboplatin.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Brain Neoplasms / therapy. Carboplatin / therapeutic use. Glioblastoma / therapy. Hyperbaric Oxygenation
  • [MeSH-minor] Adult. Aged. Astrocytoma / drug therapy. Astrocytoma / radiotherapy. Astrocytoma / surgery. Astrocytoma / therapy. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / radiotherapy. Brain Stem Neoplasms / surgery. Brain Stem Neoplasms / therapy. Chromatography, High Pressure Liquid. Combined Modality Therapy. Cranial Irradiation. Drug Synergism. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / therapy. Salvage Therapy. Treatment Outcome

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  • (PMID = 19465788.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; BG3F62OND5 / Carboplatin
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23. Patel AJ, Fox BD, Fulkerson DH, Yallampalli S, Illner A, Whitehead WE, Curry DJ, Luerssen TG, Jea A: Posterior reversible encephalopathy syndrome during posterior fossa tumor resection in a child. J Neurosurg Pediatr; 2010 Oct;6(4):377-80
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  • In addition, a single case of intraoperative (posterior fossa craniotomy) PRES has been reported; however, this case occurred in an adult.
  • During tumor resection, untoward force was used to circumferentially dissect the tumor, and excessive manipulation of the brainstem led to severe hypertension for a 10-minute period.
  • [MeSH-major] Astrocytoma / surgery. Hypertensive Encephalopathy / etiology. Infratentorial Neoplasms / surgery. Intraoperative Complications / etiology. Posterior Leukoencephalopathy Syndrome / etiology

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  • [CommentIn] J Neurosurg Pediatr. 2011 Nov;8(5):535; author's reply 535 [22044382.001]
  • (PMID = 20887113.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Sandri A, Sardi N, Genitori L, Giordano F, Peretta P, Basso ME, Bertin D, Mastrodicasa L, Todisco L, Mussa F, Forni M, Ricardi U, Cordero di Montezemolo L, Madon E: Diffuse and focal brain stem tumors in childhood: prognostic factors and surgical outcome. Experience in a single institution. Childs Nerv Syst; 2006 Sep;22(9):1127-35
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  • [Title] Diffuse and focal brain stem tumors in childhood: prognostic factors and surgical outcome. Experience in a single institution.
  • OBJECTIVE: Brainstem tumors (BSTs) are usually gliomas and are divided into diffuse BSTs (DBSTs) and focal BSTs (FBSTs).
  • [MeSH-major] Astrocytoma / surgery. Brain Stem Neoplasms / surgery. Ganglioglioma / surgery
  • [MeSH-minor] Adolescent. Adult. Brain Stem / pathology. Brain Stem / surgery. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Cranial Irradiation. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Infant. Male. Prognosis. Radiation-Sensitizing Agents / administration & dosage. Radiotherapy, Adjuvant. Survival Rate. Vincristine / administration & dosage

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  • (PMID = 16568342.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiation-Sensitizing Agents; 5J49Q6B70F / Vincristine
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25. Wakabayashi T, Natsume A, Hatano H, Fujii M, Shimato S, Ito M, Ohno M, Ito S, Ogura M, Yoshida J: p16 promoter methylation in the serum as a basis for the molecular diagnosis of gliomas. Neurosurgery; 2009 Mar;64(3):455-61; discussion 461-2
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  • The aim of this study was to detect aberrant p16 promoter methylation as a potential diagnostic marker in the serum of patients with diffuse glioma to differentiate between gliomas and, particularly, to differentiate those in the brainstem from others; this was done by using the modified methylation-specific polymerase chain reaction technique.
  • In addition, the serum DNA in 7 patients with a brainstem tumor (4 gliomas, 1 schwannoma, 1 cavernous angioma, and 1 ependymoma) was analyzed.
  • RESULTS: We found p16 methylation in 12 (60%) of the 20 tissues with astrocytoma, but in only 1 of the tissues with oligodendroglioma.
  • Additionally, p16 promoter methylation in the serum was observed in all brainstem astrocytoma cases, but not in other cases.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA, Neoplasm / blood. DNA, Neoplasm / genetics. Genes, p16. Glioma / diagnosis. Glioma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. DNA Methylation / genetics. Female. Genetic Predisposition to Disease / genetics. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 19240607.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm
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26. Wu-Chen WY, Jacobs DA, Volpe NJ, Dalmau JO, Moster ML: Intracranial malignancies occurring more than 20 years after radiation therapy for pituitary adenoma. J Neuroophthalmol; 2009 Dec;29(4):289-95
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  • The brainstem abnormality was presumptively diagnosed as a malignant glioma.
  • A 63-year-old man developed a malignant astrocytoma of the left optic nerve and chiasm 23 years after partial excision and radiation of a nonsecreting pituitary adenoma.
  • [MeSH-major] Adenoma / radiotherapy. Brain Stem Neoplasms / etiology. Glioma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Optic Nerve Neoplasms / etiology. Pituitary Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. Male. Middle Aged. Time Factors

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  • (PMID = 19952902.001).
  • [ISSN] 1536-5166
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Hayashi M, Hachiya Y, Arai N: An autopsy case presenting repetitive hypoglycemia and unique cortical dysplasia. Brain Dev; 2010 Apr;32(4):289-92
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  • Various endocrine tests, abdominal CT and brain MRI failed to demonstrate abnormalities.
  • A well-demarcated pilocytic astrocytoma was present in the brainstem.
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male

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  • [Copyright] Copyright (c) 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19303727.001).
  • [ISSN] 1872-7131
  • [Journal-full-title] Brain & development
  • [ISO-abbreviation] Brain Dev.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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28. Stark AM, Fritsch MJ, Claviez A, Dörner L, Mehdorn HM: Management of tectal glioma in childhood. Pediatr Neurol; 2005 Jul;33(1):33-8
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  • Histology was obtained in 5 cases (low-grade astrocytoma, n = 4; ependymoma, n = 1).
  • Tectal glioma represents a distinct subgroup of brainstem tumors associated with a good (or favorable) prognosis.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / therapy. Glioma / pathology. Glioma / therapy. Superior Colliculi / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Management. Female. Follow-Up Studies. Humans. Infant. Male. Retrospective Studies

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  • (PMID = 15876519.001).
  • [ISSN] 0887-8994
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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29. Chen CC, Cheng PW, Tseng HM, Young YH: Posterior cranial fossa tumors in young adults. Laryngoscope; 2006 Sep;116(9):1678-81
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  • Magnetic resonance imaging scan demonstrated space-occupying lesions at the cerebellopontine angle in 11, cerebellum in two, brainstem in two, and jugular fossa in one.
  • Diagnoses consisted of vestibular schwannoma and neurofibromatosis II in eight patients (50%), glial neoplasm (including astrocytoma, ependymoma, glioma) in four patients (25%), epidermoid cyst in three patients, and glomus jugulare tumor in one patient.
  • [MeSH-minor] Adolescent. Adult. Audiometry. Electronystagmography. Female. Hearing Loss, Sensorineural / etiology. Humans. Male. Nystagmus, Pathologic / etiology. Retrospective Studies. Vertigo / etiology

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  • (PMID = 16955003.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Terasaki M, Bouffet E, Katsuki H, Fukushima S, Shigemori M: Pilot trial of the rate of response, safety, and tolerability of temozolomide and oral VP-16 in patients with recurrent or treatment-induced malignant central nervous system tumors. Surg Neurol; 2008 Jan;69(1):46-50
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  • BACKGROUND: The aim of this study was to determine the response and toxicity of patients with recurrent or treatment-induced brain tumors to TMZ and oral VP-16.
  • METHODS: Eleven patients with recurrent or treatment-induced malignant CNS tumors, including treatment-induced PNET (in 1 patient), brainstem glioma (in 3 patients; 1 with treatment-induced, 2 with recurrence), recurrent anaplastic astrocytoma (in 3 patients), and recurrent glioblastoma (in 4 patients) were evaluated in a pilot study of TMZ and oral VP-16 chemotherapy.
  • CONCLUSION: This limited pilot study confirms the innocuousness and the activity of the combination of TMZ and oral VP-16 in recurrent malignant brain tumors.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Etoposide / administration & dosage. Neoplasm Recurrence, Local / drug therapy. Neoplasms, Neuroepithelial / drug therapy. Neoplasms, Second Primary / drug therapy
  • [MeSH-minor] Administration, Oral. Adolescent. Adult. Aged. Drug Therapy, Combination. Female. Humans. Male. Middle Aged. Pilot Projects. Treatment Outcome

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  • (PMID = 18054615.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 6PLQ3CP4P3 / Etoposide; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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31. Narayana A, Yamada J, Berry S, Shah P, Hunt M, Gutin PH, Leibel SA: Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results. Int J Radiat Oncol Biol Phys; 2006 Mar 1;64(3):892-7
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  • The median progression-free survival time for anaplastic astrocytoma and glioblastoma histology was 5.6 and 2.5 months, respectively.
  • The mean brainstem dose also decreased by 7%.
  • Intensity-modulated radiotherapy delivered with a limited number of beams did not result in an increased dose to the normal brain.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Glioma / radiotherapy. Radiotherapy, Intensity-Modulated
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brain / radiation effects. Disease Progression. Female. Glioblastoma / radiotherapy. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Oligodendroglioma / radiotherapy. Radiotherapy Dosage. Retrospective Studies

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  • (PMID = 16458777.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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32. Yamada M, Tanaka H, Morita T, Takahashi H: Separate CNS lesions involving the brainstem and spinal cord in a 47-year-old man. Neuropathology; 2008 Jun;28(3):341-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Separate CNS lesions involving the brainstem and spinal cord in a 47-year-old man.
  • [MeSH-major] Astrocytoma / pathology. Brain Stem Neoplasms / pathology. Glioblastoma / pathology. Neoplasms, Multiple Primary / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Multiple Sclerosis / pathology

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  • (PMID = 18021196.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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