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Items 1 to 100 of about 349
1. Arrese T, González P, Ramos A, Ruiz J, Lobato RD: [Idiopathic hypertrophic pachymeningitis of the cavernous sinus mimicking meningioma with complete occlusion of the carotid artery]. Neurocirugia (Astur); 2005 Feb;16(1):63-6
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  • [Title] [Idiopathic hypertrophic pachymeningitis of the cavernous sinus mimicking meningioma with complete occlusion of the carotid artery].
  • [Transliterated title] Paquimeningitis crónica hipertrófica del seno cavernoso simulando meningioma con oclusión completa de la arteria carótida.
  • We present the case of a patient with IHPM who was diagnosed of meningioma and showed a complete occlusion of the intracavernous carotid artery.
  • This 42 years old woman was sent to our hospital to be treated radiosurgicaly with the diagnosis of meningioma.
  • The differential diagnosis between meningioma and IHPM may be complex because of the similarities in image findings and the temporal resistance to corticosteroids shown by IHPM, thus we emphasize the usefulness of the SPECT to differentiate between inflammation and tumor in this clinical setting.
  • [MeSH-major] Cavernous Sinus / metabolism. Cavernous Sinus / pathology. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Meningitis / diagnosis
  • [MeSH-minor] Adult. Anti-Inflammatory Agents / therapeutic use. Brain / pathology. Brain / radionuclide imaging. Carotid Stenosis / diagnosis. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 15756414.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents
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2. Loh JK, Hwang SL, Tsai KB, Kwan AL, Howng SL: Sphenoid ridge lymphoplasmacyte-rich meningioma. J Formos Med Assoc; 2006 Jul;105(7):594-8
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  • [Title] Sphenoid ridge lymphoplasmacyte-rich meningioma.
  • There are numerous histologic variants of meningioma.
  • We report a 22-year-old woman with lymphoplasmacyte-rich meningioma who initially presented with dizziness and progressive headache.
  • Complete macroscopic removal of the tumor was performed.
  • Histologic examination revealed a meningioma with massive infiltrates of plasma cells and lymphocytes.
  • Brain computed tomography on the 6th postoperative day revealed total removal of the tumor with marked reduction of brain edema.
  • Complete resolution of symptoms occurred with no evidence of tumor recurrence during 2 years of follow-up.

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  • (PMID = 16877241.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 19
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3. Chamberlain MC, Glantz MJ: Cerebrospinal fluid-disseminated meningioma. Cancer; 2005 Apr 1;103(7):1427-30
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  • [Title] Cerebrospinal fluid-disseminated meningioma.
  • BACKGROUND: Intracranial meningiomas are common and comprise 20% of all primary brain tumors.
  • Multiple sites of metastases were seen in all patients and were both within the nervous system (subarachnoid or ventricular tumor: intracranial in eight patients, spinal cord in four patients) and extraneural (subcutaneous, cervical lymph nodes, orbit, or pulmonary in five patients).
  • CONCLUSIONS: The treatment of CSF-disseminated meningioma, although feasible and comparatively nontoxic, was associated with modest outcomes despite combined systemic and intraventricular chemotherapy.
  • [MeSH-major] Meningioma / secondary
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Central Nervous System Neoplasms / secondary. Cerebrospinal Fluid / cytology. Female. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Skin Neoplasms / secondary. Spinal Cord Neoplasms / secondary

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 15690330.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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4. Moradi A, Semnani V, Djam H, Tajodini A, Zali AR, Ghaemi K, Nikzad N, Madani-Civi M: Pathodiagnostic parameters for meningioma grading. J Clin Neurosci; 2008 Dec;15(12):1370-5
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  • [Title] Pathodiagnostic parameters for meningioma grading.
  • In this study the relationship between pathodiagnostic parameters, histological grade, and MIB-1 monoclonal antibody expression in meningioma diagnosed over 10 years in Shohada Hospital, Tehran, was assessed.
  • There was no relationship between the location of the tumor and the histopathological features.
  • Histopathological study of completely resected meningiomas showed that loss of architecture, frequent mitotic figures, a high cellularity, increased nucleo-cytoplasmic ratio, a prominent nucleolus, brain invasion, and necrosis were correlated with the grade of the meningiomas.
  • Overall, the mitotic count was the most important marker for tumor grade.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningioma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Iran. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Ubiquitin-Protein Ligases / metabolism. X-Ray Microtomography. Young Adult

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  • (PMID = 18819804.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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5. Lynch JC, Emmerich JC, Kislanov S, Gouvêa F, Câmara L, Santos Silva SM, D'Ippolito MM: [Brain tumors and pregnancy]. Arq Neuropsiquiatr; 2007 Dec;65(4B):1211-5
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  • [Title] [Brain tumors and pregnancy].
  • [Transliterated title] Tumor cerebral e gravidez.
  • BACKGROUND: Despite not being a common fact, the occurrence of brain tumors during pregnancy poses a risk to both the mother and infant.
  • AIM: To identify the best medical procedure to be followed for a pregnant patient harboring a brain tumor.
  • METHOD: The records of 6 patients with brain tumors, diagnosed during pregnancy were examined.
  • RESULTS: Several types of brain tumors have been associated with pregnancy, but the meningioma is, by far, the most frequent.
  • CONCLUSION: The best moment to recommend the craniotomy and the neurosurgical removal of the tumor will depend of the mothers neurological condition, the tumor histological type as well as the gestational age.
  • [MeSH-major] Brain Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Craniotomy. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Retrospective Studies

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  • (PMID = 18345432.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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6. Ono K, Hatada J, Minamimura K, Ohara I, Wada K: Delayed enlargement of brain edema after resection of intracranial meningioma: two case reports. Neurol Med Chir (Tokyo); 2009 Oct;49(10):478-81
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  • [Title] Delayed enlargement of brain edema after resection of intracranial meningioma: two case reports.
  • Two patients underwent uneventful total removal of convexity or trigone meningioma, but subsequently edema enlarged causing symptoms 3-4 weeks later.
  • VEGF secreted by the tumor might have resulted in spread of inflammation due to MCH in the brain parenchyma.
  • However, the risk of this phenomenon can probably be minimized by ensuring that MCH is removed as effectively as possible after use, or by refraining from use in the brain parenchyma and by taking care to connect the residual cavity to the ventricular system, particularly if the tumor contacts a cerebral ventricle.
  • [MeSH-major] Brain Edema / etiology. Cerebral Ventricle Neoplasms / complications. Meningeal Neoplasms / complications. Meningioma / complications. Postoperative Complications / etiology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Brain / pathology. Brain / physiopathology. Brain / surgery. Cerebrospinal Fluid Pressure / physiology. Collagen / adverse effects. Encephalitis / etiology. Encephalitis / pathology. Encephalitis / physiopathology. Humans. Hydrocephalus, Normal Pressure / etiology. Hydrocephalus, Normal Pressure / pathology. Hydrocephalus, Normal Pressure / physiopathology. Lateral Ventricles / pathology. Lateral Ventricles / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Time Factors. Vascular Endothelial Growth Factor A / analysis. Vascular Endothelial Growth Factor A / metabolism. Young Adult

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  • (PMID = 19855147.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A; 9007-34-5 / Collagen
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7. Santhosh K, Kesavadas C, Radhakrishnan VV, Thomas B, Kapilamoorthy TR, Gupta AK: Rhabdoid and papillary meningioma with leptomeningeal dissemination. J Neuroradiol; 2008 Oct;35(4):236-9
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  • [Title] Rhabdoid and papillary meningioma with leptomeningeal dissemination.
  • Rhabdoid meningioma is a rare variant of meningioma classified as grade III under the new World Health Organization (WHO) classification of brain tumors.
  • Although this tumor is known for its aggressive behavior, dissemination into cerebral spinal fluid (CSF) is extremely rare.
  • We report here a case of rhabdoid meningioma in a young man, operated on twice previously, who presented with multiple CSF areas of seeding in the brain and spinal cord.
  • The imaging findings for this tumor, including diffusion and perfusion MR sequences, are highlighted.
  • This particular histological subtype of meningioma has a poor prognosis and must be treated aggressively.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Rhabdoid Tumor / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Spinal Cord Neoplasms / secondary

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  • (PMID = 18325590.001).
  • [ISSN] 0150-9861
  • [Journal-full-title] Journal of neuroradiology. Journal de neuroradiologie
  • [ISO-abbreviation] J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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8. Binello E, Bederson JB, Kleinman GM: Hemangiopericytoma: collision with meningioma and recurrence. Neurol Sci; 2010 Oct;31(5):625-30
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  • [Title] Hemangiopericytoma: collision with meningioma and recurrence.
  • Intracranial hemangiopericytomas are a rare type of primary brain tumor, representing only about 0.5% of all primary brain tumors.
  • Even more rare is the co-existence of two juxtaposed primary brain tumors, termed a "collision" tumor.
  • This report provides the first documentation in the literature of a hemangiopericytoma colliding with a meningioma, and recurring after treatment with gross total resection.
  • Results were classically representative of a hemangiopericytoma (World Health Organization grade II) and of a meningioma (World Health Organization grade I).
  • This report of a unique collision tumor not only augments the repertoire of collision tumor combinations described in literature but also provides follow-up on the clinical outcome of the patient, thereby raising clinically relevant issues ranging from presentation to treatment paradigms.
  • [MeSH-major] Brain Neoplasms / complications. Hemangiopericytoma / complications. Meningeal Neoplasms / complications. Meningioma / complications. Neoplasm Recurrence, Local / complications
  • [MeSH-minor] Adult. Antigens, CD34 / metabolism. Humans. Magnetic Resonance Imaging. Male. Recurrence

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  • (PMID = 20198500.001).
  • [ISSN] 1590-3478
  • [Journal-full-title] Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
  • [ISO-abbreviation] Neurol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD34
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9. Dutta D, Lee HN, Munshi A, Gupta T, Kane S, Sridhar E, Jalali R: Intracerebral cystic rhabdoid meningioma. J Clin Neurosci; 2009 Aug;16(8):1073-4
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  • [Title] Intracerebral cystic rhabdoid meningioma.
  • An MRI of the brain revealed a left temporal intracerebral cystic lesion with rim enhancement.
  • The patient was diagnosed as having an intracerebral cystic rhabdoid meningioma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Meningioma / diagnosis. Meningioma / therapy. Rhabdoid Tumor / diagnosis. Rhabdoid Tumor / therapy
  • [MeSH-minor] Adult. Brain / pathology. Brain / radiation effects. Brain / surgery. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19427788.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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10. Takei H, Schmiege L, Buckleair L, Goodman JC, Powell SZ: Intracerebral schwannoma clinically and radiologically mimicking meningioma. Pathol Int; 2005 Aug;55(8):514-9
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  • [Title] Intracerebral schwannoma clinically and radiologically mimicking meningioma.
  • Microscopically, the tumor demonstrated classic biphasic Antoni type A and B patterns, admixed with degenerative changes.
  • The differential diagnosis includes fibrous meningioma, solitary fibrous tumor, and ICS.
  • [MeSH-major] Brain Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Calbindin 2. Diagnosis, Differential. Female. Frontal Lobe / chemistry. Frontal Lobe / pathology. Frontal Lobe / ultrastructure. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Parietal Lobe / chemistry. Parietal Lobe / pathology. Parietal Lobe / ultrastructure. Pregnancy. Pregnancy Complications, Neoplastic. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis

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  • (PMID = 15998381.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins
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11. Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S: Radiation-induced meningioma. Neurosurg Focus; 2008;24(5):E7
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  • [Title] Radiation-induced meningioma.
  • The long-term or delayed side effects of irradiation on neural tissue are now known to include the induction of new central nervous system neoplasms.
  • Emphasis is placed on meningiomas resulting from childhood treatment for primary brain tumor or tinea capitis, exposure to dental x-rays, and exposure to atomic explosions in Hiroshima and Nagasaki.
  • The authors review the typical presentation of patients with RIMs and discuss unique aspects of the surgical management of these tumors compared with sporadic meningioma, based on their clinical experience in treating these lesions.
  • [MeSH-major] Cranial Irradiation / adverse effects. Meningeal Neoplasms / etiology. Meningioma / etiology. Neoplasms, Radiation-Induced / etiology
  • [MeSH-minor] Adolescent. Adult. Alopecia / etiology. Brain Neoplasms / radiotherapy. Child. Cohort Studies. Dose-Response Relationship, Radiation. Female. Humans. Japan / epidemiology. Male. Neoplasm Invasiveness. Neoplasms, Second Primary / etiology. Neoplasms, Second Primary / radiotherapy. Neoplasms, Second Primary / surgery. Nuclear Warfare. Radiation Injuries / epidemiology. Radiation Injuries / etiology. Radiation Injuries / prevention & control. Radiography, Dental / adverse effects. Radiosurgery / adverse effects. Radiotherapy / trends. Tinea Capitis / radiotherapy

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  • [CommentIn] Neurosurg Focus. 2008;24(5):E6; discussion E6 [18447745.001]
  • (PMID = 18447746.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Portraits; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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12. Bollag RJ, Vender JR, Sharma S: Anaplastic meningioma: progression from atypical and chordoid morphotype with morphologic spectral variation at recurrence. Neuropathology; 2010 Jun;30(3):279-87
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  • [Title] Anaplastic meningioma: progression from atypical and chordoid morphotype with morphologic spectral variation at recurrence.
  • Recent literature evokes two pathways to disease progression in meningiomas akin to a comparable paradigm in gliomas, but without similar prognostic connotation: de novo anaplastic meningioma (better prognosis), and transformed meningioma (worse prognosis).
  • We present two adult cases of transformed meningiomas that display a spectrum of morphologic progression.
  • Case 1 at presentation showed a random admixture of meningothelial, atypical and anaplastic meningioma.
  • The tumor recurred as anaplastic meningioma.
  • Case 2 presented as a chordoid meningioma, but recurred as anaplastic meningioma mainly at the invasive front in transition with residual chordoid pattern.
  • Of interest, portions of tumor also showed papillary configuration.
  • In accordance with the dire prognosis for anaplastic meningioma, both patients succumbed to their disease within 2 months of recurrence.
  • The present study highlights two main points: First, that proper recognition of focal high-grade areas in a heterogeneous low-grade meningioma (case 1) provides critical morphologic clues to spatial histologic progression and predicts aggressive biologic behavior, as evidenced by progression to frankly anaplastic meningioma at recurrence.
  • Second, the presence of papillary in addition to anaplastic areas, in the recurrence of a previously diagnosed chordoid meningioma supports the ostensibly heightened transforming potential of grade II meningiomas, but also reflects on the morphologic heterogeneity of high-grade meningiomas, and their potentially diverse pathways of progression.
  • We propose that grading of meningiomas as outlined by WHO is of more critical prognostic import than histologic sub-typing, and must include a thorough survey of the tumor-brain interface.
  • Future molecular genetic correlates, akin to those characterized in gliomas, could help stratify prognostic subcategories to refine meningioma grading, and govern optimal therapeutic strategies.
  • [MeSH-major] Choroid Plexus Neoplasms / diagnosis. Choroid Plexus Neoplasms / pathology. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Meningioma / diagnosis. Meningioma / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology

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  • (PMID = 19780983.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
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13. Liu Y, Tian RF, Li YM, Liu WP, Cao L, Yang XL, Cao WD, Zhang X: The expression of seven 14-3-3 isoforms in human meningioma. Brain Res; 2010 Jun 8;1336:98-102
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  • [Title] The expression of seven 14-3-3 isoforms in human meningioma.
  • 14-3-3 proteins comprise a large family of highly conserved, acidic polypeptides, expressed in all eukaryotic organisms, with highest concentration found in the brain.
  • However, the expression of seven 14-3-3 isoforms in meningioma still remains unknown.
  • This study is the first examination of 14-3-3 isoforms in three grades of meningioma by immunohistochemistry.
  • 14-3-3epsilon, zeta and theta were specifically expressed in meningioma, and their expression levels increased with the increase of pathological grade of meningioma.
  • The 14-3-3 eta, beta, gamma and sigma isoforms were negatively expressed in meningioma.
  • In conclusion, The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma.
  • [MeSH-major] 14-3-3 Proteins / biosynthesis. Meningeal Neoplasms / metabolism. Meningeal Neoplasms / pathology. Meningioma / metabolism. Meningioma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Protein Isoforms / biosynthesis. Young Adult

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20388496.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / Protein Isoforms
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14. Chang JH, Kim JA, Chang JW, Park YG, Kim TS: Sylvian meningioma without dural attachment in an adult. J Neurooncol; 2005 Aug;74(1):43-5
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  • [Title] Sylvian meningioma without dural attachment in an adult.
  • This paper presents a rare case of a sylvian meningioma in a 35-year-old male.
  • The tumor was not stained on angiogram.
  • The tumor was located in the extra-axial space of the sylvian fissure without any dural attachment, and was strongly attached to the middle cerebral artery.
  • The tumor was excised, and a histological diagnosis of a transitional meningioma without a malignancy was made.
  • A Sylvian meningioma without dural attachment is quite rare, and a preoperative differentiation of this lesion is generally difficult.
  • [MeSH-major] Dura Mater / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Cerebral Artery / pathology. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16078106.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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15. Olivera M, Martínez C, Molina JA, Alonso-Navarro H, Jiménez-Jiménez FJ, García-Martín E, Benítez J, Agúndez JA: Increased frequency of rapid acetylator genotypes in patients with brain astrocytoma and meningioma. Acta Neurol Scand; 2006 May;113(5):322-6
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  • [Title] Increased frequency of rapid acetylator genotypes in patients with brain astrocytoma and meningioma.
  • We investigated the association between the genetic NAT2 polymorphism and brain tumors by analysis of genomic DNA from 71 brain tumor patients and 258 healthy controls.
  • A higher number of individuals carrying functional NAT2 genes, and therefore with a rapid acetylation phenotype, was found in brain tumor patients vs healthy volunteers (OR 1.79, 95% CI 1.05-3.05; P < 0.05).
  • This is observed either for patients suffering from meningioma or astrocytoma, and this is due to an increase of the wild-type NAT2*4 allelic variant frequency (OR 1.48, 95% CI 0.99-2.19), and a reduction of the commonest defective allelic variant NAT2*5B in the brain tumor patients, compared with healthy subjects (OR 0.54, 95% CI 0.37-0.80).
  • CONCLUSIONS: This observation indicates that NAT2 could be considered as a low-penetrance gene for brain tumors, and that individuals carrying rapid acetylation alleles are at increased risk of developing brain tumors.
  • [MeSH-major] Arylamine N-Acetyltransferase / genetics. Astrocytoma / genetics. Brain Neoplasms / genetics. Meningeal Neoplasms / genetics. Meningioma / genetics. Polymorphism, Single Nucleotide / genetics
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Female. Humans. Male. Middle Aged. Penetrance. Polymerase Chain Reaction

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  • (PMID = 16629768.001).
  • [ISSN] 0001-6314
  • [Journal-full-title] Acta neurologica Scandinavica
  • [ISO-abbreviation] Acta Neurol. Scand.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.3.1.5 / Arylamine N-Acetyltransferase; EC 2.3.1.5 / NAT2 protein, human
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16. Kano T, Nakazato Y, Tamura M, Ohye C, Zama A, Saito F, Tomizawa S: Ultrastructural and immunohistochemical study of an adult case of chordoid meningioma. Brain Tumor Pathol; 2009;26(1):37-42
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  • [Title] Ultrastructural and immunohistochemical study of an adult case of chordoid meningioma.
  • Magnetic resonance imaging revealed a large meningeal tumor with some cysts in the right frontal region.
  • Surgical resections were performed three times, and local radiation therapy was administered twice over a period of 8 years for the treatment of tumor recurrences.
  • The tumor tended to recur in spite of the surgical and radiation therapies.
  • The tumor was diagnosed as a chordoid meningioma, and the second surgical specimen showed increasing nuclear atypia and mitoses in tumor cells.
  • An immunohistochemical study revealed the tumor cells were positive for vimentin, S-100 protein, and cytokeratin AE1/AE3.
  • The tumor cell surfaces displayed pseudopodia which extended into the intercellular spaces and the tumor cells had moderate quantities of cytoplasm containing abundant mitochondria and glycogen granules.
  • [MeSH-major] Meningioma / pathology

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  • (PMID = 19408096.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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17. Lee JW, Kang KW, Park SH, Lee SM, Paeng JC, Chung JK, Lee MC, Lee DS: 18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma. Eur J Nucl Med Mol Imaging; 2009 Oct;36(10):1574-82
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  • [Title] 18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma.
  • PURPOSE: The purpose of this study was to investigate the role of (18)F-fluorodeoxyglucose (FDG) PET in detecting high-grade meningioma and predicting the recurrence in patients with meningioma after surgical resection.
  • METHODS: Fifty-nine patients (27 men and 32 women) with intracranial meningioma who underwent preoperative FDG PET and subsequent surgical resection were enrolled.
  • All patients underwent clinical follow-up for tumor recurrence with a mean duration of 34+/-20 months.
  • The tumor to gray matter ratio (TGR) of FDG uptake was calculated and a receiver-operating characteristic (ROC) curve of the TGR was drawn to determine the cutoff value of the TGR for detection of high-grade meningioma.
  • Further, univariate analysis with the log-rank test was performed to assess the predictive factors of meningioma recurrence.
  • RESULTS: The TGR in high-grade meningioma (WHO grade II and III) was significantly higher than that in low-grade ones (WHO grade I) (p=0.002) and significantly correlated with the MIB-1 labeling index (r=0.338, p=0.009) and mitotic count of the tumor (r=0.284, p=0.03).
  • The ROC analysis revealed that the TGR of 1.0 was the best cutoff value for detecting high-grade meningioma with a sensitivity of 43%, specificity of 95%, and accuracy of 81%.
  • In the log-rank test, the TGR, MIB-1 labeling index, presence of brain invasion, and WHO grade were significantly associated with tumor recurrence.
  • The cumulative recurrence-free survival rate of patients with a TGR of 1.0 or less was significantly higher than that of patients with a TGR of more than 1.0 (p=0.0003) CONCLUSION: FDG uptake in meningioma was the significant predictive factor of tumor recurrence and significantly correlated with the proliferative potential of the tumor.
  • [MeSH-major] Brain Neoplasms / diagnostic imaging. Fluorodeoxyglucose F18. Meningioma / diagnostic imaging. Radiopharmaceuticals
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Fluorine Radioisotopes. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnostic imaging. Positron-Emission Tomography. ROC Curve

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  • (PMID = 19377904.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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18. Chamberlain MC, Tsao-Wei DD, Groshen S: Salvage chemotherapy with CPT-11 for recurrent meningioma. J Neurooncol; 2006 Jul;78(3):271-6
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  • [Title] Salvage chemotherapy with CPT-11 for recurrent meningioma.
  • BACKGROUND: A prospective Phase II study of irinotecan (CPT-11) in adult patients with recurrent surgery and radiotherapy-refractory WHO Grade I meningioma.
  • METHODS: Sixteen patients (5 men; 11 women) ages 48-70 years (median 62.5), with recurrent meningioma were treated.
  • Time to tumor progression ranged from 2.5 to 5.0 months (median 5.0 months).
  • Using CPT-11 in this moderately toxic dose schedule failed to demonstrate efficacy in this cohort of adult patients with recurrent surgery and radiotherapy-refractory meningioma.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Brain Neoplasms / drug therapy. Camptothecin / analogs & derivatives. Meningioma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Salvage Therapy

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  • (PMID = 16628476.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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19. Suga Y, Tsutsumi S, Higo T, Kondo A, Abe Y, Yasumoto Y, Ito M: [Huge falx meningioma resected en bloc following acute brain swelling: a case report]. No Shinkei Geka; 2008 Sep;36(9):819-23
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  • [Title] [Huge falx meningioma resected en bloc following acute brain swelling: a case report].
  • Surgery of a meningioma is composed of four essential consecutive steps; devascularization, detachment, debulking, and dissection.
  • However, this is not the case with a huge meningioma in which circumferential devascularization and detachment may be difficult to complete before debulking is attempted.
  • We report a case of a 37-year-old female presented headache, memory disturbance, and character change and sustaining a huge falx meningioma, with hypervascular appearance.
  • Intraoperatively her blood pressure decreased to 45/30 mmHg due to profuse bleeding caused by "premature debulking" followed by significant brain swelling, which pushed out the tumor from the underlying brain after detachment of the tumor from the falx, and, consequently, yielded en bloc removal like a birth delivery.
  • The histopathological diagnosis was angiomatous meningioma with prominent capillary proliferation without findings of celluar atypia.
  • We thought that relative hyperemia in the brain surrounding the tumor, which was induced by the craniotomy, and acute brain ischemia caused by the intraoperative significant hypotension, might facilitate en bloc removal.
  • We should be aware that huge meningiomas may cause intraoperative acute brain swelling as well as significant blood loss.
  • Also we should carefully consider the indication and select proper candidates for presurgical cerebral angiography and tumor embolization because of the inherent risk that is apt to be underestimated.
  • [MeSH-major] Brain Edema / etiology. Intraoperative Complications / etiology. Meningeal Neoplasms / complications. Meningeal Neoplasms / surgery. Meningioma / complications. Meningioma / surgery
  • [MeSH-minor] Acute Disease. Adult. Blood Loss, Surgical. Female. Humans

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  • (PMID = 18800638.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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20. Rezanko T, Tunakan M, Kahraman A, Sucu HK, Gelal F, Akkol I: Primary rhabdoid tumor of the brain in an adult. Neuropathology; 2006 Feb;26(1):57-61
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  • [Title] Primary rhabdoid tumor of the brain in an adult.
  • Rhabdoid tumor (RT) is an uncommon childhood neoplasm that typically arises within the kidney.
  • Since its description in 1978, several cases of primary extrarenal RT, including a CNS localization, have been reported.
  • The first case in the CNS was reported in 1985 and was defined as "rhabdoid tumor" initially, and was classified as grade IV in the most recent classification of the World Health Organization under the term of "atypical teratoid/rhabdoid tumor".
  • Nearly 200 cases of atypical teratoid/rhabdoid tumor of the CNS have been reported to date, most of them occurring in childhood.
  • We report a case of primary RT of the brain located in the right frontal lobe with the clinical, radiographic and pathological features presenting at an unusual age.
  • This tumor, which was composed purely of rhabdoid cells with no additional primitive neuroectodermal, epithelial and mesenchymal components, was in a 27-year-old male patient.
  • In conclusion, RT should be considered also in the differential diagnosis of intracerebral neoplasms of adult patients.
  • [MeSH-major] Brain Neoplasms / pathology. Rhabdoid Tumor / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Meningioma / pathology

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  • (PMID = 16521480.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. Schmid S, Aboul-Enein F, Pfisterer W, Birkner T, Stadek C, Knosp E: Vascular endothelial growth factor: the major factor for tumor neovascularization and edema formation in meningioma patients. Neurosurgery; 2010 Dec;67(6):1703-8; discussion 1708
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  • [Title] Vascular endothelial growth factor: the major factor for tumor neovascularization and edema formation in meningioma patients.
  • BACKGROUND: Peritumoral brain edema (PTBE) may be crucial in the clinical outcome of meningioma patients.
  • Sex, age, tumor size, location, involvement of other structures, or the histological appearance was not found to sufficiently explain PTBE formation in meningiomas.
  • Pre- and postoperative magnetic resonance imaging including 3-dimensional reconstruction of 1.3-mm thick layers, with calculation of tumor and edema volume, was performed.
  • RESULTS: VEGF was found to be exclusively confined to meningioma tumor cells.
  • VEGF and supplying pial vessels were found in 14 meningioma patients, pial vascular supply only in 3, VEGF expression only in 46, and neither VEGF expression nor supplying pial vessels in 16.
  • Only the occurrence of both pial vascular supply and tumor VEGF expression was found to be correlated with PTBE formation (P<.002).
  • [MeSH-major] Brain Edema / etiology. Gene Expression Regulation, Neoplastic / physiology. Meningeal Neoplasms / complications. Meningioma / complications. Neovascularization, Pathologic / etiology. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Regression Analysis. Statistics, Nonparametric. Young Adult

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  • (PMID = 21107201.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A
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22. McIver JI, Scheithauer BW, Atkinson JL: Deep Sylvian fissure chordoid meningioma: case report. Neurosurgery; 2005 Nov;57(5):E1064; discussion E1064
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  • [Title] Deep Sylvian fissure chordoid meningioma: case report.
  • OBJECTIVE AND IMPORTANCE: A case of chordoid meningioma originating in the right sylvian fissure is reported.
  • This is the first reported case of a chordoid meningioma without dural attachment arising in the sylvian fissure.
  • A heterogeneously enhancing right frontotemporal mass was identified on magnetic resonance imaging of the brain.
  • The tumor was ultimately resected using standard microsurgical techniques.
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging / methods. Male. Meningioma. Neurosurgery / methods

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  • (PMID = 16284544.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Al-Habib A, Lach B, Al Khani A: Intracerebral rhabdoid and papillary meningioma with leptomeningeal spread and rapid clinical progression. Clin Neuropathol; 2005 Jan-Feb;24(1):1-7
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  • [Title] Intracerebral rhabdoid and papillary meningioma with leptomeningeal spread and rapid clinical progression.
  • OBJECTIVE AND IMPORTANCE: Rhabdoid meningioma (RM) is a relatively new, Grade III tumor entity according to the latest WHO classification.
  • We report rhabdoid and partly papillary, highly anaplastic, intracerebral meningioma with diffuse leptomeningeal spread and distant SCF metastasis to the cervical cord.
  • CLINICAL PRESENTATION: This 27-year-old female was admitted to the hospital with radiological findings suggestive of a primary brain tumor or a metastasis.
  • After subtotal resection and during radiotherapy, follow-up MRI revealed recurrence, metastasis to meninges at the high cervical level, and diffuse basal leptomeningeal enhancement indicating infiltrating tumor.
  • RESULTS: Histological examination revealed rhabdoid and papillary meningioma with high proliferation rate (80% of MIB1-positive cells), necrosis and extensive brain invasion.
  • The recurrent tumor diffusely infiltrated leptomeninges and subarachnoid space.
  • CONCLUSION: This is a rare example of mixed, rhabdoid and papillary variant of meningioma, located entirely within the brain parenchyma and accompanied by a fulminant clinical course.
  • [MeSH-major] Arachnoid / pathology. Frontal Lobe. Meningeal Neoplasms / secondary. Meningeal Neoplasms / surgery. Meningioma / secondary. Meningioma / surgery. Pia Mater / pathology
  • [MeSH-minor] Adult. Brain / pathology. Disease Progression. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Time Factors

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  • (PMID = 15696777.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 34
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24. Senbokuya N, Asahara T, Uchida M, Yagishita T, Naganuma H: Atypical meningioma with large cyst. Case report. Neurol Med Chir (Tokyo); 2006 Mar;46(3):147-51
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  • [Title] Atypical meningioma with large cyst. Case report.
  • Computed tomography and magnetic resonance imaging showed a solid, enhanced tumor with a cyst in the left frontal area with surrounding edema and mild mass effect.
  • The preoperative diagnosis was cystic falx meningioma.
  • The tumor was totally resected, but most of the cyst wall adhered tightly to the surrounding brain and could not be removed.
  • Histological examination revealed atypical meningioma and tumor cells in the cyst wall.
  • [MeSH-major] Cysts / complications. Meningeal Neoplasms / complications. Meningioma / complications
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 16565585.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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25. Jain D, Sharma MC, Sarkar C, Suri V, Garg A, Singh M, Sharma BS, Mahapatra AK: Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J Neurooncol; 2007 Feb;81(3):315-21
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  • [Title] Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases.
  • AIMS: Clear cell meningioma (CCM) is an uncommon variant of meningioma, which affect younger patients, occur more often in spinal or cerebello pontine locations and shows a higher recurrence rate.
  • Radiologically lesions showed homogenous enhancement and were isointense to brain parenchyma.
  • Histopathologic examination revealed tumor cells to be arranged in sheets with clear cytoplasm and monomorphic nuclei.
  • CONCLUSIONS: CCM is a rare variant of meningioma with poor outcome.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Sex Factors. Tomography, X-Ray Computed

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  • (PMID = 16955223.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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26. Shinoura N, Takahashi M, Yamada R: Delineation of brain tumor margins using intraoperative sononavigation: implications for tumor resection. J Clin Ultrasound; 2006 May;34(4):177-83
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  • [Title] Delineation of brain tumor margins using intraoperative sononavigation: implications for tumor resection.
  • PURPOSE: Sonography has been employed for real-time intraoperative delineation of tumor boundaries during resection of brain tumors.
  • However, the variably hyperechoic appearance of brain edema or gliosis surrounding the brain may interfere with accurate depiction of tumor margins.
  • The goal of the present study was to use sononavigation, which provides coregistration between real-time sonograms and MRI scans, to assess the accuracy of sonographic determination of tumor margins.
  • METHODS: Sononavigation was performed on 12 brain tumors (7 metastatic brain tumors, 2 meningiomas, 1 anaplastic oligodendroglioma, 1 anaplastic pilocytic astrocytoma, and 1 anaplastic astrocytoma).
  • Sonograms of tumor margins were categorized into 1 of 3 types: in type 1, the tumor margin was clearly visualized and corresponded to the margin of the enhanced lesion on MR scan in all areas; in type 2, the tumor margin was clearly seen in some areas but was obscure in others due to hyperechoic edema; and in type 3, the tumor margin was indistinguishable from surrounding tissues in all areas.
  • RESULTS: Three metastatic brain tumors and 1 meningioma were categorized as type 1.
  • Three metastatic brain tumors, 1 meningioma, and 1 anaplastic oligodendroglioma were categorized as type 2.
  • The anaplastic pilocytic astrocytoma, 1 metastatic brain tumor (which consisted mainly of necrotic tissue), and the anaplastic astrocytoma were categorized as type 3.
  • These data assist in determining whether the sonographic appearance of tumor margins is accurate and whether to rely on information from either sonography (type 1) or the sononavigation system when resecting tumor types 1, 2, and 3.
  • CONCLUSIONS: Sononavigation can help categorize the sonographic tumor margins into 3 different patterns, and this categorization can assist in determining which imaging modalities are needed to better delineate the tumor margins for subsequent resection.
  • [MeSH-major] Brain Neoplasms / surgery. Brain Neoplasms / ultrasonography. Neuronavigation / methods. Ultrasonography, Interventional / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Intraoperative Period. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies

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  • [Copyright] Copyright 2006 Wiley Periodicals, Inc.
  • (PMID = 16615048.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
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27. Tena-Suck ML, Collado-Ortìz MA, Salinas-Lara C, García-López R, Gelista N, Rembao-Bojorquez D: Chordoid meningioma: a report of ten cases. J Neurooncol; 2010 Aug;99(1):41-8
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  • [Title] Chordoid meningioma: a report of ten cases.
  • Chordoid meningioma is a rare variant of meningioma with histological features resembling those of chordoma.
  • This tumor has a great risk of recurrence and aggressive growth (WHO grade II).
  • This study was done to document the clinical and pathological features of ten patients with chordoid meningioma who submitted to surgery at the National Institute of Neurology and Neurosurgery in Mexico City.
  • The tumor was localized in eight cases in the supratentorial compartments.
  • Two of the ten tumors showed metaplasic changes, and seven showed brain invasion.
  • Tumor cells demonstrated CK7, EMA and focal S-100 protein and Ep-CAM.
  • The mean rate of the MIB-1 labeling index in recurrences was 7.1% versus 6.33% for no tumor recurrence.
  • Chordoid meningioma, World Health Organization grade II, is an uncommon variant of meningioma with a propensity for aggressive behavior and increased likelihood of recurrence.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Meningeal Neoplasms / metabolism. Meningeal Neoplasms / pathology. Meningioma / metabolism. Meningioma / pathology
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / metabolism. Cell Adhesion Molecules / metabolism. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Ki-67 Antigen / metabolism. Male. Middle Aged. Mucin-1 / metabolism. Retrospective Studies. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 20094774.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin
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28. Tawil A, Comair Y, Nasser H, Hourani R, Rebeiz J, Chamoun R: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract; 2008;204(6):413-22
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  • [Title] Periosteal osteoblastoma of the calvaria mimicking a meningioma.
  • While osteoblastoma of the cranial vault is rare, the periosteal form of the tumor is highly unusual, with only one case reported in the English literature.
  • Magnetic resonance imaging of the brain showed an extra-axial temporal mass with findings that were suggestive of a meningioma.
  • The tumor was strongly positive for epithelial membrane antigen, a feature not previously described in osteoblastoma, and one that could lead to a mistaken diagnosis of metaplastic meningioma in a limited sample.
  • Accurate histological diagnosis of a calvarial osteoblastoma requires adequate sampling of the tumor, including its interface with adjacent structures.
  • Correlation with the radiological findings is crucial for the diagnosis in most cases; however, it is not helpful in differentiating the rare intracranial periosteal variant from a meningioma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Meningioma / diagnosis. Osteoblastoma / diagnosis. Skull / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Mucin-1 / analysis. Treatment Outcome

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  • (PMID = 18359169.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1
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29. Asgari S, Bassiouni H, Hunold A, Klassen D, Stolke D, Sandalcioglu IE: Extensive brain swelling with neurological deterioration after intracranial meningioma surgery - venous complication or 'unspecific' increase in tissue permeability. Zentralbl Neurochir; 2008 Feb;69(1):22-9
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  • [Title] Extensive brain swelling with neurological deterioration after intracranial meningioma surgery - venous complication or 'unspecific' increase in tissue permeability.
  • OBJECTIVE: We retrospectively analyzed a series of patients who deteriorated after resection of an intracranial meningioma due to extensive brain edema (EBE) with regard to etiology of the neurological worsening and outcome.
  • METHODS: Out of a series of 376 consecutive patients who underwent resection of an intracranial meningioma, 13 (3.5%) experienced postoperative deterioration due to EBE which necessitated prolonged artificial ventilation, tracheal reintubation, or decompressive craniectomy.
  • Mean tumor volume in this group was higher when compared to group A (75 ml vs. 30 ml).
  • CONCLUSION: Extensive brain swelling during or after intracranial meningioma surgery may be due to VI or possibly due to increased postoperative tissue permeability.
  • [MeSH-major] Brain Edema / etiology. Brain Neoplasms / surgery. Cerebrovascular Disorders / etiology. Meningioma / surgery. Nervous System Diseases / etiology. Neurosurgical Procedures / adverse effects. Postoperative Complications / epidemiology
  • [MeSH-minor] Adult. Aged. Cerebral Infarction / etiology. Cerebral Infarction / pathology. Cerebral Veins / pathology. Constriction. Data Interpretation, Statistical. Female. Follow-Up Studies. Glasgow Outcome Scale. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18393161.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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30. Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD: Risk of meningioma and common variation in genes related to innate immunity. Cancer Epidemiol Biomarkers Prev; 2010 May;19(5):1356-61
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  • [Title] Risk of meningioma and common variation in genes related to innate immunity.
  • BACKGROUND: The etiology of meningioma, the second most common type of adult brain tumor in the United States, is largely unknown.
  • Prior studies indicate that history of immune-related conditions may affect the risk of meningioma.
  • METHODS: To identify genetic markers for meningioma in genes involved with innate immunity, we conducted an exploratory association study of 101 meningioma cases and 330 frequency-matched controls of European ancestry using subjects from a hospital-based study conducted by the National Cancer Institute.
  • Risk of meningioma was estimated by odds ratios and 95% confidence intervals.
  • RESULTS: Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.
  • CONCLUSIONS AND IMPACT: Our results indicate that common genetic polymorphisms in innate immunity genes may be associated with risk of meningioma.
  • Given the small sample size, replication of these results in a larger study of meningioma is needed.

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  • [Copyright] Copyright (c) 2010 AACR
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  • (PMID = 20406964.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / N01CO12400; United States / Intramural NIH HHS / / Z99 CA999999; United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ NIHMS184299; NLM/ PMC3169167
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31. Kaynar MY, Sanus GZ, Hnimoglu H, Kacira T, Kemerdere R, Atukeren P, Gumustas K, Canbaz B, Tanriverdi T: Expression of hypoxia inducible factor-1alpha in tumors of patients with glioblastoma multiforme and transitional meningioma. J Clin Neurosci; 2008 Sep;15(9):1036-42
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  • [Title] Expression of hypoxia inducible factor-1alpha in tumors of patients with glioblastoma multiforme and transitional meningioma.
  • The aim of this study was to assess HIF-1alpha in 22 patients with transitional meningioma (TM) and 26 patients with glioblastoma multiforme (GBM).
  • There was no statistically significant difference between the two types of tumor (p=0.264).
  • These findings indicate that HIF-1alpha is elevated in both TM and GBM, suggesting that although hypoxia is one of the most important and powerful stimuli for HIF-1alpha elevation and consequently angiogenesis, other mechanisms may play roles in HIF-1alpha stimulation in benign brain tumors such as TM.
  • [MeSH-major] Brain Neoplasms / metabolism. Glioblastoma / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism
  • [MeSH-minor] Adult. Aged. Anoxia / diagnosis. Anoxia / metabolism. Anoxia / physiopathology. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cell Hypoxia / physiology. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neovascularization, Pathologic / etiology. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / physiopathology. Predictive Value of Tests. Up-Regulation / physiology

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  • (PMID = 18621534.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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32. Fisher JL, Schwartzbaum JA, Wrensch M, Berger MS: Evaluation of epidemiologic evidence for primary adult brain tumor risk factors using evidence-based medicine. Prog Neurol Surg; 2006;19:54-79
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  • [Title] Evaluation of epidemiologic evidence for primary adult brain tumor risk factors using evidence-based medicine.
  • We evaluate genetic, behavioral, developmental and experiential risk factors for primary adult brain tumors (primarily, astrocytoma and meningioma) using a systematic set of principles adapted from evidence-based medicine standards.
  • In addition to ionizing radiation, rare mutations in highly penetrant genes associated with certain diseases/syndromes, and epilepsy and seizures (which probably result from, rather than cause, adult brain tumors), only the unexplained observation of familial aggregation of astrocytoma has been consistently shown.
  • There is promising renewed interest in associations between infections, allergic conditions and adult brain tumor risk.
  • Our knowledge of the causes of adult brain tumors is limited and should be expanded by results from large, well-designed studies of novel potential risk factors and potential interactions between known and suspected risk factors.
  • [MeSH-major] Brain Neoplasms / etiology. Epidemiologic Methods. Evidence-Based Medicine / methods
  • [MeSH-minor] Astrocytoma / etiology. Humans. Meningioma / etiology. Risk Assessment. Risk Factors

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  • (PMID = 17033147.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 142
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33. Tella OI Jr, Paiva Neto MA, Herculano MA, Faedo Neto A: [Olfactory groove meningioma]. Arq Neuropsiquiatr; 2006 Mar;64(1):83-7
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  • [Title] [Olfactory groove meningioma].
  • There were nine complete resections including duramater and infiltrate bone and four patients with tumor removal and duramater coagulation.
  • One patient died on post-operative period due to brain infarction and three patients had cerebrospinal fluid fistula that resolved.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Postoperative Complications. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16622559.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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34. Bruna J, Brell M, Ferrer I, Gimenez-Bonafe P, Tortosa A: Ki-67 proliferative index predicts clinical outcome in patients with atypical or anaplastic meningioma. Neuropathology; 2007 Apr;27(2):114-20
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  • [Title] Ki-67 proliferative index predicts clinical outcome in patients with atypical or anaplastic meningioma.
  • Meningiomas represent the second most common central nervous system neoplasms in adults and account for 26% of all primary brain tumors.
  • Although histological grade is the most relevant prognostic factor, there are some unusual cases in which establishing a diagnosis of high-grade meningioma following 2000 World Health Organization (WHO) histological criteria is extremely difficult.
  • Therefore, the aim of the present study was to evaluate the predictive value of Ki-67 labeling index and its contribution to current WHO classification in predicting tumor recurrence and overall survival in patients with high-grade meningiomas.
  • In the univariate analysis, Ki-67 labeling index and postoperative Karnofsky performance status were identified as significant prognostic factors of tumor recurrence and overall survival.
  • The multivariate analysis demonstrated that Ki-67 labeling index is the only independent predictor of both tumor recurrence and overall survival.
  • More importantly, this predictive value was maintained in both patients with atypical and patients with anaplastic meningioma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Ki-67 Antigen / metabolism. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Proliferation. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis. ROC Curve. Sensitivity and Specificity. Survival Analysis

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  • [CommentIn] Neuropathology. 2008 Feb;28(1):106-7 [18181839.001]
  • (PMID = 17494511.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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35. Chen YY, Tiang XY, Li Z, Luo BN, Huang Q: Sporadic meningioangiomatosis-associated atypical meningioma mimicking parenchymal invasion of brain: a case report and review of the literature. Diagn Pathol; 2010;5:39
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  • [Title] Sporadic meningioangiomatosis-associated atypical meningioma mimicking parenchymal invasion of brain: a case report and review of the literature.
  • Meningioangiomatosis is a rare hamartomatous lesion or meningiovascular malformation in brain.
  • In extremely rare condition, meningioma may occur together with meningioangiomatosis, and only 19 cases have been described in English literature until now.
  • We now report a case of meningioangiomatosis-associated meningioma with atypical and clear cell variant.
  • Microscopically, parts of lesions were atypical and clear cell meningioma corresponding to WHO grade II.
  • The adjacent brain parenchyma showed the histological features of meningioangiomatosis.
  • Neoplastic cells in atypical meningioma area were immunoreactive to epithelial membrane antigen (EMA) with high MIB-1 index of up to 20%.
  • The diagnosis of atypical meningioma associated with sporadic meningioangiomatosis was made.
  • To our knowledge, this is the first case of a meningioangiomatosis-associated meningioma with atypical and clear cell variant component to be described.
  • No tumor recurrence was found during this period.
  • Meningioangiomatosis-associated meningioma is more likely to occur in younger patients and histologically to mimic parenchymal invasion of brain.
  • We suggest that postoperative radiotherapy or chemotherapy should be given careful consideration to avoid over-treatment due to erroneously interpret as malignant meningioma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Central Nervous System Vascular Malformations / diagnosis. Cerebral Cortex / pathology. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Treatment Outcome

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  • [Cites] Surg Neurol. 2006 Jun;65(6):595-603 [16720184.001]
  • [Cites] Am J Surg Pathol. 2002 Jan;26(1):125-9 [11756780.001]
  • (PMID = 20565869.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2904739
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36. Schwartzbaum J, Jonsson F, Ahlbom A, Preston-Martin S, Malmer B, Lönn S, Söderberg K, Feychting M: Prior hospitalization for epilepsy, diabetes, and stroke and subsequent glioma and meningioma risk. Cancer Epidemiol Biomarkers Prev; 2005 Mar;14(3):643-50
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  • [Title] Prior hospitalization for epilepsy, diabetes, and stroke and subsequent glioma and meningioma risk.
  • We conducted a case-control study to evaluate the preclinical association between epilepsy, diabetes, and stroke and primary adult brain tumors.
  • We first identified all 1,501 low-grade glioma, 4,587 high-grade glioma (HGG), and 4,193 meningioma cases reported to the Swedish Cancer Registry from 1987 to 1999.
  • Results are similar for glioblastoma multiforme, low-grade glioma, and meningioma.
  • In contrast, risk of HGG among people discharged with diabetes or stroke does not increase until year of brain tumor diagnosis.
  • [MeSH-major] Brain Neoplasms / etiology. Diabetes Complications. Diabetes Mellitus / therapy. Epilepsy / complications. Glioma / etiology. Meningeal Neoplasms / etiology. Meningioma / etiology. Stroke / complications
  • [MeSH-minor] Adult. Age of Onset. Aged. Case-Control Studies. Female. Hospitalization. Humans. Male. Middle Aged. Risk Factors. Time Factors


37. Malmer BS, Feychting M, Lönn S, Lindström S, Grönberg H, Ahlbom A, Schwartzbaum J, Auvinen A, Collatz-Christensen H, Johansen C, Kiuru A, Mudie N, Salminen T, Schoemaker MJ, Swerdlow AJ, Henriksson R: Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma. J Neurooncol; 2007 May;82(3):229-37
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  • [Title] Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma.
  • BACKGROUND: P53 and ATM are central checkpoint genes involved in the repair of DNA damage after ionising irradiation, which has been associated with risk of brain tumours.
  • Therefore, we tested the hypothesis that polymorphisms and haplotypes in p53 and ATM could be associated with glioma and meningioma risk.
  • MATERIAL AND METHODS: Six hundred and eighty glioma cases (298 glioblastoma (GBM)), 503 meningioma cases, and 1555 controls recruited in the Nordic-UK Interphone study, were analysed in association with three polymorphisms in p53 (rs2287499, rs1042533, rs1625895) and five polymorphisms in ATM ( rs228599, rs3092992, rs664143, rs170548, rs3092993).
  • The haplotype analysis in ATM revealed an increased frequency of the 1-1-1-2-1 haplotype in meningioma cases (33.8%) compared with controls (30.3%) (p = 0.03).
  • The 2-1-2-1-1 haplotype had a lower frequency in meningioma cases (36.1%) than controls (40.7%) (p = 0.009).
  • CONCLUSIONS: This study found both positive and negative associations of haplotypes in p53 for glioblastoma and ATM for meningioma.
  • This study provides new data that could add to our understanding of brain tumour susceptibility.
  • [MeSH-major] Brain Neoplasms / genetics. Cell Cycle Proteins / genetics. DNA-Binding Proteins / genetics. Glioma / genetics. Meningeal Neoplasms / genetics. Meningioma / genetics. Protein-Serine-Threonine Kinases / genetics. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Aged. Ataxia Telangiectasia Mutated Proteins. Case-Control Studies. Female. Genetic Predisposition to Disease. Haplotypes. Humans. Male. Middle Aged. Polymorphism, Single Nucleotide. Risk Factors

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  • (PMID = 17151932.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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38. Armstrong L, Graham GE, Schimke RN, Collins DL, Kirse DJ, Costello F, Ardinger HH: The Hunter-MacDonald syndrome with expanded phenotype including risk of meningioma: an update and review. Am J Med Genet A; 2008 Jan 1;146A(1):83-92
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  • [Title] The Hunter-MacDonald syndrome with expanded phenotype including risk of meningioma: an update and review.
  • Decreased hearing acuity, transient cranial nerve palsies, congenital heart defects, and meningioma are also reported.
  • Herein, we present two cases, and, through review of the manifestations of HMS in affected and at-risk family members, we have observed that predisposition to brain tumor is a cardinal feature of this condition.
  • [MeSH-major] Abnormalities, Multiple / genetics. Meningeal Neoplasms / genetics. Meningioma / genetics. Phenotype
  • [MeSH-minor] Adult. Child. Female. Genes, Dominant. Hearing Loss / genetics. Hearing Loss / physiopathology. Humans. Male. Pedigree. Risk Factors. Syndrome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17972300.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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39. Tamura Y, Miyatake S, Nonoguchi N, Miyata S, Yokoyama K, Doi A, Kuroiwa T, Asada M, Tanabe H, Ono K: Boron neutron capture therapy for recurrent malignant meningioma. Case report. J Neurosurg; 2006 Dec;105(6):898-903
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  • [Title] Boron neutron capture therapy for recurrent malignant meningioma. Case report.
  • Malignant meningioma is a rare brain tumor with a high risk of recurrence.
  • If this tumor recurs after complete resection and adjuvant radiotherapy, there is no optimal treatment to control it.
  • The authors report the first case of recurrent malignant meningioma treated using boron neutron capture therapy (BNCT).
  • This 25-year-old pregnant woman presented with a large frontal tumor.
  • After her baby was born, she underwent gross-total resection of the tumor.
  • The minimum tumor dose and maximum brain tissue dose were estimated as 39.7 Gy-Eq and less than 9.0 Gy-Eq, respectively.
  • Twenty-two weeks later she underwent a second BNCT for tumor regrowth on the contralateral side, and the lesion was subsequently reduced.
  • The tumor volume was markedly decreased from 65.6 cm3 at the time of the first BNCT to 31.8 cm3 at 26 weeks thereafter.
  • The treatment of recurrent malignant meningioma is difficult and has been discouraging thus far.
  • Data in the present case indicate that BNCT may be a promising treatment option for this challenging tumor.
  • [MeSH-major] Boron Neutron Capture Therapy. Cranial Irradiation. Meningeal Neoplasms / radiotherapy. Meningioma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Pregnancy Complications, Neoplastic / radiotherapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neurologic Examination. Positron-Emission Tomography. Pregnancy. Radiosurgery. Radiotherapy Dosage. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 17405262.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Bacciu A, Piazza P, Di Lella F, Sanna M: Intracanalicular meningioma: clinical features, radiologic findings, and surgical management. Otol Neurotol; 2007 Apr;28(3):391-9
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  • [Title] Intracanalicular meningioma: clinical features, radiologic findings, and surgical management.
  • The aim of this study is to describe the clinical, radiologic, and histopathologic features of 13 intracanalicular meningiomas highlighting important aspects of tumor diagnosis and treatment.
  • PATIENTS: Thirteen consecutive patients with pathologically confirmed intracanalicular meningioma surgically treated between December 1988 and July 2006.
  • RESULTS: Total tumor removal was achieved in all cases.
  • On account of a lack of specific symptoms and the limited diagnostic findings, preoperative diagnosis of intracanalicular meningioma still represents a diagnostic challenge.
  • [MeSH-major] Ear Neoplasms / pathology. Ear Neoplasms / surgery. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery. Otologic Surgical Procedures / methods. Vestibular Aqueduct / pathology. Vestibular Aqueduct / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry, Pure-Tone. Evoked Potentials, Auditory, Brain Stem. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / diagnosis. Postoperative Complications / epidemiology. Retrospective Studies

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  • (PMID = 17287658.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Takahashi S, Ohira T, Shido S, Kawase T: Focal hand dystonia cured by removal of clinoid meningioma-case report-. Neurol Med Chir (Tokyo); 2009 Dec;49(12):619-21
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  • [Title] Focal hand dystonia cured by removal of clinoid meningioma-case report-.
  • A 40-year-old Asian female presented with an unusual case of focal hand dystonia caused by contralateral clinoid meningioma.
  • Magnetic resonance imaging showed that the tumor compressed the caudate nucleus, lentiform nucleus, cerebral peduncle, internal capsule, and a large portion of the white matter surrounding the basal ganglia.
  • The tumor was gross totally removed via a frontotemporal approach with zygomatic osteotomy, resulting in cure of the focal hand dystonia.
  • Magnetic resonance imaging after surgery showed that the compression of the surrounding brain was released.
  • This case shows that secondary focal hand dystonia caused by extra-axial brain tumor can be cured by surgical removal.
  • [MeSH-major] Dystonic Disorders / etiology. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Basal Ganglia / pathology. Basal Ganglia / physiopathology. Basal Ganglia Diseases / etiology. Basal Ganglia Diseases / pathology. Basal Ganglia Diseases / physiopathology. Decompression, Surgical / methods. Disease Progression. Female. Hand / innervation. Hand / physiopathology. Humans. Internal Capsule / pathology. Internal Capsule / physiopathology. Magnetic Resonance Imaging. Neoplasm Invasiveness / pathology. Neural Pathways / pathology. Neural Pathways / physiopathology. Neurosurgical Procedures / methods. Sphenoid Bone / pathology. Sphenoid Bone / surgery. Tegmentum Mesencephali / pathology. Tegmentum Mesencephali / physiopathology. Treatment Outcome

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  • (PMID = 20035142.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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42. Sanai N, Sughrue ME, Shangari G, Chung K, Berger MS, McDermott MW: Risk profile associated with convexity meningioma resection in the modern neurosurgical era. J Neurosurg; 2010 May;112(5):913-9
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  • [Title] Risk profile associated with convexity meningioma resection in the modern neurosurgical era.
  • Patients with multiple meningiomas, hemangiopericytomas, malignant meningiomas, or tumor-prone syndromes were excluded from analysis.
  • RESULTS: Between 1997 and 2007, 141 consecutive patients (median age 48 years, range 18-95 years) underwent resection of a supratentorial convexity meningioma.
  • The mean tumor volume was 146.3 cm3 (range 1-512 cm3).
  • Six patients (4%) had radiographic evidence of tumor recurrence, with 3 (2%) undergoing repeat resection.
  • [MeSH-major] Meningioma / pathology. Meningioma / surgery. Neurosurgical Procedures / methods. Radiosurgery / methods. Supratentorial Neoplasms / pathology. Supratentorial Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Intraoperative Complications / epidemiology. Intraoperative Complications / prevention & control. Male. Microsurgery / instrumentation. Middle Aged. Risk Assessment. Risk Factors. Young Adult

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  • (PMID = 19645533.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Monleón D, Morales JM, Gonzalez-Darder J, Talamantes F, Cortés O, Gil-Benso R, López-Ginés C, Cerdá-Nicolás M, Celda B: Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling. J Proteome Res; 2008 Jul;7(7):2882-8
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  • [Title] Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling.
  • Meningiomas are neoplasms that arise from the leptomeningeal covering of the brain and spinal cord, accounting for 15%-20% of CNS tumors.
  • Sometimes, meningiomas with histological diagnosis of benign meningioma show clinical characteristics of atypical meningioma.
  • In this context, high-resolution magic-angle spinning (HR-MAS) spectroscopy of intact tissue from brain tumor biopsies has shown great potential as a support diagnostic tool.
  • In this work, we show differences between benign and atypical meningiomas in HR-MAS molecular profiles of meningioma biopsies.
  • Metabolic differences between meningioma grades include changes in the levels of glutathione.
  • Glutamine and glutamate, which are related to glutathione metabolism and have been associated with tumor recurrence, are also increased in atypical meningiomas.
  • Other metabolites associated with tumor malignancy that show statistically significant differences between benign and atypical meningiomas include phosphocholine and phosphoethanolamine.
  • Overall, this work suggests that the additional information obtained by NMR metabolomics applied to biopsies of human meningiomas may be useful for assessing tumor grade and determining optimum treatment strategies.
  • [MeSH-major] Meningeal Neoplasms / metabolism. Meningioma / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Gene Expression Profiling. Humans. Magnetic Resonance Spectroscopy. Male. Middle Aged. Principal Component Analysis

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  • (PMID = 18507434.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Cassereau J, Lavigne C, Michalak-Provost S, Ghali A, Dubas F, Fournier HD: An intraventricular clear cell meningioma revealed by an inflammatory syndrome in a male adult: a case report. Clin Neurol Neurosurg; 2008 Jul;110(7):743-6
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  • [Title] An intraventricular clear cell meningioma revealed by an inflammatory syndrome in a male adult: a case report.
  • Clinical symptoms are mainly due to an increased intracranial pressure or a direct pressure on the surrounding brain structures.
  • Here we report a case of right intraventricular clear cell meningioma in a 50-year-old man who presented with fever, headache, and inflammatory syndrome.
  • Clinical and biological normalization was rapidly obtained after tumor removal.
  • Immunohistochemical examination showed tumor cells and lymphocytes positivity for the pyrogenic cytokine interleukin-6, with a same intensity.
  • To our knowledge, this is the first case described in the literature concerning an adult man with an intraventricular clear cell meningioma associated with a systemic inflammatory syndrome.
  • [MeSH-major] Inflammation / pathology. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 18514392.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Interleukin-6
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45. Paiva Neto MA, Tella OI Jr, Herculano MA, Stávale JN, Bonatteli AP: [Olfactory groove meningioma: correlation between clinicoradiological features and proliferative index (Mib-1)]. Arq Neuropsiquiatr; 2006 Mar;64(1):77-82
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  • [Title] [Olfactory groove meningioma: correlation between clinicoradiological features and proliferative index (Mib-1)].
  • OBJECTIVE: The aim of this study is to correlationate demographic, radiologic features and proliferative index defined by immunohistochemical expression of Mib-1 in olfactory groove meningiomas, and to observe possible predictive factors of recurrence of this tumor.
  • METHOD: There were analysed demographic, clinical and radiological features of 15 patients with olfactory groove meningioma.
  • Two cases with tumor recurrence had proliferative indices higher than the mean index.
  • [MeSH-major] Ki-67 Antigen / metabolism. Meningeal Neoplasms / pathology. Meningioma / pathology. Meningioma / radiography. Neoplasm Proteins / metabolism. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal / analysis. Brain Edema / pathology. Brain Edema / radiography. Cell Division / physiology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16622558.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins
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46. Lah TT, Nanni I, Trinkaus M, Metellus P, Dussert C, De Ridder L, Rajcević U, Blejec A, Martin PM: Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors. J Neurosurg; 2010 May;112(5):940-50
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  • [Title] Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors.
  • The second aim was to confirm if cathepsin B and/or cathepsin L and their endogenous inhibitors were also prognostic parameters in the clinical study of 119 patients with meningioma.
  • METHODS: Primary meningioma cultured spheroids were "confronted" with embryonic chick heart spheroids in vitro, and cathepsin B was used as molecular marker to immunolabel the invasive tumor cells.
  • In vitro invasion assays of the malignant meningioma cells were used to assess the invasive potential related to the cysteine cathepsins.
  • As to the second aim, the possible association of cathepsin B along with selected molecular markers, cathepsin L, and endogenous cysteine protease inhibitors (stefins A and B and cystatin C) with meningioma malignancy was determined using enzyme-linked immunosorbent assays in tumor homogenates.
  • Univariate and multivariate analyses were used to compare these parameters with established biological markers of meningioma recurrence in 119 patients with meningiomas.
  • More intensive staining of cathepsin B in these tumors was not only found at the tumor front, but also in the invading pseudopodia of a single migrating tumor cells.
  • Matrigel invasion of malignant meningioma cells was significantly altered by modulating cathepsin B activity and by stefin B silencing.
  • In the clinical samples of meningioma, the levels of cathepsins B and L, stefin B, and cystatin C were highest in the tumors of higher histological grades, whereas stefin A and progesterone receptor were the only markers that were significantly increased and decreased, respectively, in WHO Grade III lesions.
  • As expected, WHO grade, age, and Simpson grade (complete tumor resection) were prognostic, with Simpson grade only relevant in the short term (up to 90 months) but not in longer-term follow-up.
  • CONCLUSIONS: The data indicate that the cysteine cathepsins and their inhibitors are involved in a process related to early meningioma recurrence, regardless of their histological classification.
  • Of note, the known tumor invasiveness marker cathepsin B, measured in whole-tumor homogenates, was not prognostic, in contrast to its endogenous inhibitor stefin B, which was highly significant and the only independent prognostic factor to predict meningioma relapse in multivariate analysis and reported herein for the first time.
  • [MeSH-major] Brain Neoplasms / drug therapy. Brain Neoplasms / pathology. Cysteine Proteinase Inhibitors / pharmacology. Cysteine Proteinase Inhibitors / therapeutic use. Lysosomes / drug effects. Meningioma / drug therapy. Meningioma / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cathepsin B / genetics. Cystatin A / genetics. Cystatin B / genetics. Female. Gene Silencing. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Neurosurgical Procedures. World Health Organization. Young Adult

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  • (PMID = 19747051.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CSTB protein, human; 0 / Cystatin A; 0 / Cysteine Proteinase Inhibitors; 88844-95-5 / Cystatin B; EC 3.4.22.1 / CTSB protein, human; EC 3.4.22.1 / Cathepsin B
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47. Epstein NE, Drexler S, Schneider J: Clear cell meningioma of the cauda equina in an adult: case report and literature review. J Spinal Disord Tech; 2005 Dec;18(6):539-43
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  • [Title] Clear cell meningioma of the cauda equina in an adult: case report and literature review.
  • Preoperative noncontrast MR studies of the brain and cervical and thoracic spine were negative.
  • Frozen-section diagnosis confirmed clear cell tumor.
  • Differential diagnoses included meningioma versus renal cell carcinoma.
  • Negative postoperative chest, abdominal, and pelvic computed tomography studies ruled out tumor of renal cell origin.
  • The high recurrence rate for clear cell meningiomas in children requires repeated tumor resection with or without secondary radiation therapy.
  • [MeSH-major] Cauda Equina / pathology. Cauda Equina / surgery. Meningioma / diagnosis. Meningioma / surgery. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Paresis / diagnosis. Paresis / etiology. Treatment Outcome

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  • (PMID = 16306847.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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48. Schüz J, Böhler E, Berg G, Schlehofer B, Hettinger I, Schlaefer K, Wahrendorf J, Kunna-Grass K, Blettner M: Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany). Am J Epidemiol; 2006 Mar 15;163(6):512-20
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  • [Title] Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany).
  • The widespread use of cellular telephones has generated concern about possible adverse health effects, particularly brain tumors.
  • In this population-based case-control study carried out in three regions of Germany, all incident cases of glioma and meningioma among patients aged 30-69 years were ascertained during 2000-2003.
  • In total, 366 glioma cases, 381 meningioma cases, and 1,494 controls were interviewed.
  • Overall use of a cellular phone was not associated with brain tumor risk; the respective odds ratios were 0.98 (95% confidence interval (CI): 0.74, 1.29) for glioma and 0.84 (95% CI: 0.62, 1.13) for meningioma.
  • Among persons who had used cellular phones for 10 or more years, increased risk was found for glioma (odds ratio = 2.20, 95% CI: 0.94, 5.11) but not for meningioma (odds ratio = 1.09, 95% CI: 0.35, 3.37).
  • No excess of temporal glioma (p = 0.41) or meningioma (p = 0.43) was observed in cellular phone users as compared with nonusers.
  • Cordless phone use was not related to either glioma risk or meningioma risk.
  • In conclusion, no overall increased risk of glioma or meningioma was observed among these cellular phone users; however, for long-term cellular phone users, results need to be confirmed before firm conclusions can be drawn.
  • [MeSH-major] Brain Neoplasms / epidemiology. Cell Phones. Electromagnetic Fields / adverse effects. Glioma / epidemiology. Meningioma / epidemiology
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Environmental Exposure / adverse effects. Female. Germany / epidemiology. Humans. Incidence. Interviews as Topic. Male. Middle Aged. Registries. Risk Assessment. Risk Factors


49. Young JP, Young PH: Meningioma associated with abscess formation--a case report. Surg Neurol; 2005 Jun;63(6):584-5
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  • [Title] Meningioma associated with abscess formation--a case report.
  • A rare case of meningioma associated with both intratumoral and peritumoral abscess formation occurred in a 38-year-old man presenting with signs and symptoms of elevated intracranial pressure, intracranial infection, and right temporal pole mass lesion.
  • The mass lesion was totally removed, revealing a meningioma.
  • Group B streptococcus and peptostreptococcus were cultured from both the tumor and peritumoral white matter.
  • [MeSH-major] Brain Abscess / microbiology. Brain Abscess / pathology. Meningeal Neoplasms / complications. Meningeal Neoplasms / pathology. Meningioma / complications. Meningioma / pathology
  • [MeSH-minor] Adult. Dental Instruments / adverse effects. Dura Mater / pathology. Humans. Male. Neurosurgical Procedures. Oxacillin / therapeutic use. Sphenoid Bone / pathology. Streptococcal Infections / complications. Streptococcal Infections / etiology. Streptococcal Infections / physiopathology. Temporal Lobe / pathology. Treatment Outcome

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  • (PMID = 15936397.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] UH95VD7V76 / Oxacillin
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50. Boviatsis EJ, Bouras TI, Kouyialis AT, Themistocleous MS, Sakas DE: Impact of age on complications and outcome in meningioma surgery. Surg Neurol; 2007 Oct;68(4):407-11; discussion 411
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  • [Title] Impact of age on complications and outcome in meningioma surgery.
  • BACKGROUND: Surgery for benign brain tumors in elderly patients without severe general health problems is an acceptable practice, as results are comparable with the ones of younger patients.
  • Tumor removal rate was not significantly different in the 2 groups.
  • Regarding each complication, postoperative hematoma, infections, and deep vein thrombosis were more frequent in elderly patients, presenting various degrees of statistical significance, whereas postoperative brain edema, hydrocephalus, and cardiorespiratory incidents presented no statistically significant difference.
  • CONCLUSIONS: Operation for intracranial meningioma in elderly patients is justified as long as detailed preoperative evaluation is performed.
  • [MeSH-major] Meningioma / surgery. Postoperative Complications / epidemiology. Supratentorial Neoplasms / surgery
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Cerebral Hemorrhage / etiology. Craniotomy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Nervous System Diseases / epidemiology. Neurosurgical Procedures. Retrospective Studies. Treatment Outcome

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  • (PMID = 17586023.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Fu JY, Gao XG, Li SY, Wang LZ, Hu YJ: [Ectopic meningioma in oral and maxillofacial region: report of 23 cases]. Shanghai Kou Qiang Yi Xue; 2010 Feb;19(1):23-7
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  • [Title] [Ectopic meningioma in oral and maxillofacial region: report of 23 cases].
  • PURPOSE: To analyse the clinical features and treatment of ectopic meningioma (EM) in oral and maxillofacial region.
  • The primary sites of the tumor were parapharyngeal space(13), infratemporal space/ pterygopalatine space(5), temporal region(3),orbital area (1) and buccal mucosa(1).
  • The CT image of EM in the oral and maxillofacial region was similar to that in the brain.
  • All 23 cases underwent surgical treatment, seventeen cases underwent the tumor totally resected and 6 cases underwent partially resected.
  • The predilection site of the tumor is the deep space of oral and maxillofacial region with adherence to the cervical sheath and lower cranial nerves.
  • [MeSH-major] Meningioma. Mouth Neoplasms. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Female. Humans. Male. Meningeal Neoplasms. Retrospective Studies

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  • (PMID = 20300688.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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52. Drevelegas A, Xinou E, Karacostas D, Parissis D, Karkavelas G, Milonas I: Meningioma growth and interferon beta-1b treated multiple sclerosis: coincidence or relationship? Neuroradiology; 2005 Jul;47(7):516-9
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  • [Title] Meningioma growth and interferon beta-1b treated multiple sclerosis: coincidence or relationship?
  • Although the coincidence of multiple sclerosis (MS) and central nervous system (CNS) tumors has been reported in over 30 cases in English literature, meningioma growth was associated with interferon-beta (INF-b) treated MS only in two of them.
  • We report the case of a 19-year-old woman with clinically possible, laboratory supported MS, and a concomitant right intraventricular tumor with magnetic resonance imaging (MRI) characteristics consistent with meningioma (similar signal with grey matter on T1 and T2-weighted images and homogenous, intense enhancement).
  • Two years after initiation of INF-b treatment, follow-up brain MRI revealed enlargement of the intraventricular mass and relative increase in the number of white matter lesions without significant clinical deterioration.
  • She underwent almost total resection of the mass and histology confirmed the diagnosis of papillary meningioma.
  • Based on the immunohistochemistry results, we speculate that INF-b resulted in meningioma growth by enhancing platelet derived growth factor (PDGF) receptors or/and down-regulating transforming growth factor receptors on the tumor itself.
  • [MeSH-major] Adjuvants, Immunologic / adverse effects. Cerebral Ventricle Neoplasms / diagnosis. Interferon-beta / adverse effects. Magnetic Resonance Imaging. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Multiple Sclerosis / drug therapy
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Interferon beta-1b. Receptors, Platelet-Derived Growth Factor / metabolism

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  • (PMID = 15981002.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 145155-23-3 / Interferon beta-1b; 77238-31-4 / Interferon-beta; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
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53. Kashimura H, Ogasawara K, Arai H, Beppu T, Inoue T, Takahashi T, Matsuda K, Takahashi Y, Fujiwara S, Ogawa A: Fusion of magnetic resonance angiography and magnetic resonance imaging for surgical planning for meningioma--technical note. Neurol Med Chir (Tokyo); 2008 Sep;48(9):418-21; discussion 422
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  • [Title] Fusion of magnetic resonance angiography and magnetic resonance imaging for surgical planning for meningioma--technical note.
  • A fusion technique for magnetic resonance (MR) angiography and MR imaging was developed to help assess the peritumoral angioarchitecture during surgical planning for meningioma.
  • Three-dimensional time-of-flight (3D-TOF) and 3D-spoiled gradient recalled (SPGR) datasets were obtained from 10 patients with intracranial meningioma, and fused using newly developed volume registration and visualization software.
  • Fusion images showed displacement of the anterior cerebral or middle cerebral artery in 7 patients and encasement of the anterior cerebral arteries in 1 patient, with no relationship between the main arterial trunk and tumor in 2 patients.
  • Fusion of MR angiography and MR imaging can clarify relationships between the intracranial vasculature and meningioma, and may be helpful for surgical planning for meningioma.
  • [MeSH-major] Brain Neoplasms / surgery. Magnetic Resonance Angiography / methods. Magnetic Resonance Imaging / methods. Meningioma / surgery. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Patient Care Planning. Software

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  • (PMID = 18812687.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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54. Fukushima S, Terasaki M, Sakata K, Miyagi N, Kato S, Sugita Y, Shigemori M: Sensitivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases. Brain Tumor Pathol; 2009;26(2):51-7
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  • [Title] Sensitivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases.
  • Recently, anti-phosphohistone-H3 (PHH3) antibody has been reported as a mitosis-specific marker for meningioma grading.
  • In this study, we attempted PHH3 immunostaining for our meningioma cases and verified not only the sensitivity of PHH3 immunostaining but also that of its usefulness in grading meningiomas.
  • As such, PHH3 may be a sensitive and useful marker for meningioma grading as based on the MF.
  • [MeSH-major] Histones / metabolism. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Mitotic Index / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Eosine Yellowish-(YS). Female. Hematoxylin. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. Mitosis. Phosphorylation. Sensitivity and Specificity

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  • (PMID = 19856215.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Histones; 0 / Ki-67 Antigen; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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55. Lind CR, Muthiah K, Bok AP: Peritumoral Citrobacter koseri abscess associated with parasagittal meningioma. Neurosurgery; 2005 Oct;57(4):E814
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  • [Title] Peritumoral Citrobacter koseri abscess associated with parasagittal meningioma.
  • OBJECTIVE AND IMPORTANCE: This is the second report of a Citrobacter-associated brain abscess in an adult and the first report of its association with an intradural tumor.
  • Five of seven tumor-associated abscesses with a microbiological diagnosis involved gram-negative bacteria, a finding that may indicate a predilection of these microorganisms for intracranial tumors.
  • Computed tomographic imaging revealed a noncalcified, homogeneously enhancing, 3-cm-diameter, extra-axial tumor associated with the right anterior falx cerebri.
  • The tumor did not extend to the skull base.
  • INTERVENTION: At craniotomy, 10 to 20 ml of thick pus was found around the posteroinferior surface of the tumor.
  • [MeSH-major] Brain Abscess / etiology. Brain Abscess / surgery. Citrobacter koseri. Enterobacteriaceae Infections / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery

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  • (PMID = 17152669.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thienamycins; 75J73V1629 / Ceftriaxone; FV9J3JU8B1 / meropenem
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56. Curry WT, McDermott MW, Carter BS, Barker FG 2nd: Craniotomy for meningioma in the United States between 1988 and 2000: decreasing rate of mortality and the effect of provider caseload. J Neurosurg; 2005 Jun;102(6):977-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Craniotomy for meningioma in the United States between 1988 and 2000: decreasing rate of mortality and the effect of provider caseload.
  • Multivariate analyses revealed that larger-volume centers had lower mortality rates for patients who underwent craniotomy for meningioma (odds ratio [OR] 0.74, 95% confidence interval [CI] 0.59-0.93, p = 0.01).
  • The annual meningioma caseload in the US increased 83% between 1988 and 2000, from 3900 patients/year to 7200 patients/year.
  • Fewer centers hosted one meningioma resection annually, whereas the largest centers had disproportionate increases in their caseloads, indicating a modest centralization of meningioma surgery in the US during this interval.
  • CONCLUSIONS: The mortality and adverse hospital discharge disposition rates were lower when meningioma surgery was performed by high-volume providers.
  • [MeSH-major] Craniotomy / mortality. Meningeal Neoplasms / mortality. Meningeal Neoplasms / surgery. Meningioma / mortality. Meningioma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Centralized Hospital Services / statistics & numerical data. Cohort Studies. Databases, Factual. Female. Hospital Mortality / trends. Humans. Male. Middle Aged. Multivariate Analysis. Neurosurgery / statistics & numerical data. Postoperative Complications / mortality. Retrospective Studies. Risk Factors. United States / epidemiology

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  • [CommentIn] J Neurosurg. 2005 Jun;102(6):969-70; discussion 970 [16028752.001]
  • (PMID = 16028755.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Shuto T, Inomori S, Fujino H, Nagano H, Hasegawa N, Kakuta Y: Cyst formation following gamma knife surgery for intracranial meningioma. J Neurosurg; 2005 Jan;102 Suppl:134-9
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  • [Title] Cyst formation following gamma knife surgery for intracranial meningioma.
  • The tumor location was the sphenoid ridge in one case, petroclival in two, tentorium in one, and parasagittal region in one.
  • The mean tumor volume was 10.5 cm3, the mean margin dose was 13.4 Gy (median 14 Gy), and the mean maximum dose was 27.5 Gy (median 24.1 Gy).
  • Histological examination demonstrated various findings such as tumor necrosis, proliferation of small vessels, vascular obliteration, and hemosiderin deposits.
  • CONCLUSIONS: New cyst formation following GKS for benign intracranial meningioma is relatively rare; however, both preexisting and newly developed cysts tend to enlarge after GKS and often require surgery.
  • [MeSH-major] Brain Diseases / etiology. Brain Diseases / surgery. Cysts / etiology. Cysts / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Postoperative Complications. Radiosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiation Dosage

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  • (PMID = 15662796.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Yilmaz N, Dulger H, Kiymaz N, Yilmaz C, Bayram I, Ragip B, Oğer M: Lipid peroxidation in patients with brain tumor. Int J Neurosci; 2006 Aug;116(8):937-43
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  • [Title] Lipid peroxidation in patients with brain tumor.
  • Molecular and genetic signatures may predict brain tumor behavior and may soon guide tumor classification, diagnosis, and tumor-specific treatment strategies.
  • This article explored the state of FORs and antioxidant system in patients with cerebral tumor.
  • The serum concentrations of malondialdehyde (MDA), catalase, and glutathione peroxidase (GSH-Px) enzyme activities were measured in the serum of 35 patients with cerebral tumors (21 glioma, 14 meningioma) and 11 controls.
  • Mean serum MDA levels, catalase, and GSH-Px enzyme activities were significantly higher for both glial and meningiomal tumor cases when compared to controls (p < .05).
  • There is no significant difference between glioma and meningioma groups in terms of the aforementioned parameters (p > .05).
  • In conclusion, lipid peroxidation and antioxidant enzymes as assessed by MDA, catalase, and GSH-Px were increased in patients with brain tumors, for this respect there is no difference between gliomas and meningiomas.
  • [MeSH-major] Brain Neoplasms / blood. Lipid Peroxidation / physiology
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Catalase / blood. Child. Child, Preschool. Female. Glutathione Peroxidase / blood. Humans. Male. Malondialdehyde / blood. Middle Aged

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  • (PMID = 16861159.001).
  • [ISSN] 0020-7454
  • [Journal-full-title] The International journal of neuroscience
  • [ISO-abbreviation] Int. J. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4Y8F71G49Q / Malondialdehyde; EC 1.11.1.6 / Catalase; EC 1.11.1.9 / Glutathione Peroxidase
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59. Aghi M, Barker FG 2nd: Benign adult brain tumors: an evidence-based medicine review. Prog Neurol Surg; 2006;19:80-96
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  • [Title] Benign adult brain tumors: an evidence-based medicine review.
  • BACKGROUND: Benign adult brain tumors can be managed conservatively or using surgery, radiation, or medicines.
  • While randomized comparisons assessing tumor recurrence, quality of life, or survival are the ideal means of comparing treatments, it can be difficult to recruit patients to such trials and lengthy follow-up periods are needed because of the slowly progressive natural history of these tumors.
  • METHODS: Review of the literature on benign adult brain tumors using evidence-based standards and focusing on meningiomas, pituitary adenomas, and vestibular schwannomas, which together represent the majority of WHO grade 1 adult brain tumors.
  • RESULTS: Nearly all studies of benign adult brain tumors were of relatively poor quality (level 3 or poorer).
  • The safety of meningioma surgery in the elderly varies with institution, radiosurgery is a reliable alternative to surgery in small to medium-sized meningiomas, and the efficacy of drugs in therapy of meningiomas recurring after surgery is difficult to interpret due to a lack of uniform criteria in the studies.
  • CONCLUSIONS: While randomized clinical trials comparing conservative management, surgery, radiation, and medical management of benign adult benign tumors are unlikely to occur, there is some level 3 evidence that can assist in their treatment.
  • [MeSH-major] Brain Neoplasms / therapy. Evidence-Based Medicine
  • [MeSH-minor] Adenoma / therapy. Adult. Humans. Meningeal Neoplasms / therapy. Meningioma / therapy. Neuroma, Acoustic / therapy. Neurosurgical Procedures. Phototherapy. Pituitary Neoplasms / therapy. Radiosurgery

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  • (PMID = 17033148.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 58
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60. Matsuda R, Nikaido Y, Yamada T, Mishima H, Tamaki R: [High-dose radiation-induced meningioma following prophylactic cranial irradiation for acute lymphoblastic leukaemia]. No Shinkei Geka; 2005 Mar;33(3):277-80
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  • [Title] [High-dose radiation-induced meningioma following prophylactic cranial irradiation for acute lymphoblastic leukaemia].
  • The high cure rate in childhood ALL, attributable to aggressive chemotherapy and prophylatic cranial irradiation, is capable of inducing secondary brain tumor.
  • Twelve cases of high-dose radiation-induced meningioma following ALL are also reviewed.
  • [MeSH-major] Cranial Irradiation / adverse effects. Meningeal Neoplasms / etiology. Meningioma / etiology. Neoplasms, Second Primary / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
  • [MeSH-minor] Adult. Central Nervous System Neoplasms / prevention & control. Female. Humans. Radiotherapy Dosage

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  • (PMID = 15773318.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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61. Williams HM, Lundberg GA Jr: Systemic lupus erythematosus, meningioma and carcinoma of the cervix--a case report. 1956. Conn Med; 2006 Aug;70(7):453-6
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  • [Title] Systemic lupus erythematosus, meningioma and carcinoma of the cervix--a case report. 1956.
  • The history of a patient with systemic lupus erythematosus, meningioma and carcinoma of the cervix is presented.
  • Although the meningioma originally masqueraded as a cerebral manifestation of lupus, lack of response to cortisone and progression of symptoms eventually indicated the diagnosis of brain tumor.
  • [MeSH-major] Lupus Erythematosus, Systemic / history. Meningioma / history. Uterine Cervical Neoplasms / history
  • [MeSH-minor] Adult. Female. History, 20th Century. Humans


62. Garcia-Conde M, Roldan-Delgado H, Martel-Barth-Hansen D, Manzano-Sanz C: Anaplastic transformation of an atypical intraventricular meningioma with metastases to the liver: case report. Neurocirugia (Astur); 2009 Dec;20(6):541-9
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  • [Title] Anaplastic transformation of an atypical intraventricular meningioma with metastases to the liver: case report.
  • We present herein the first case of a malignant intraventricular meningioma with extraneural metastases.
  • Histological examination demonstrated an atypical meningioma.
  • Thereafter, the tumor recurred twice.
  • At first recurrence, the tumor was completely removed again and external radiotherapy was administered.
  • At surgery at second recurrence, the tumor was more aggressive, invading the brain parenchyma.
  • Histological examination showed anaplastic meningioma.
  • Biopsy was consistent with liver metastases of a malignant meningioma.
  • Therefore, when systemic deterioration occurs in a patient with a malignant intraventricular meningioma, metastases to extraneural organs such as the liver must be ruled out.
  • [MeSH-major] Anaplasia / pathology. Liver Neoplasms / secondary. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 19967319.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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63. Bakar B, Sav A, Tekkok IH: Giant chordoid meningioma symptomatic immediately after pregnancy: report of a rare case. Clin Neuropathol; 2010 May-Jun;29(3):163-8
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  • [Title] Giant chordoid meningioma symptomatic immediately after pregnancy: report of a rare case.
  • BACKGROUND: Chordoid meningioma is a very rare subtype of meningioma with less than 90 cases reported in the literature.
  • Herein, we present a pregnancy-associated case of a chordoid meningioma and briefly discuss possible mechanisms.
  • The patient was immediately taken to the operating theater and the tumor was gross totally removed.
  • The postoperative period was uneventful; and histopathological diagnosis was chordoid meningioma.
  • As for this case of chordoid meningioma associated with pregnancy, we think mucin accumulation in tumor could be involved in an increase in the tumor size while delivery procedures with the common anaesthetic and sedative drugs may also have enhanced the peritumoral edema by causing a relative decrease in the cerebral blood flow.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Adult. Biopsy. Brain / pathology. Brain Edema / pathology. Brain Edema / radiography. Cesarean Section. Female. Humans. Magnetic Resonance Imaging. Pregnancy. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 20423691.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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64. Zhi L, Bing L, Yang L, Bo-ning L, Quan H: Cystic papillary meningioma with subarachnoid dissemination: a case report and review of the literature. Pathol Res Pract; 2009;205(8):582-7
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  • [Title] Cystic papillary meningioma with subarachnoid dissemination: a case report and review of the literature.
  • The development of the papillary variant of meningiomas with cyst formation in the central nervous system is extremely rare.
  • We report a case of cystic papillary meningioma in a young female occurring in the lateral ventricle with invasion of brain parenchyma and dissemination of subarachnoid space.
  • The tumor exhibits a marked peritumoral cyst, with contrast enhancement on magnetic resonance imaging (MRI) in accordance with type 2 of Zee's classification of cystic meningioma.
  • Histologically, the tumor displays a classical perivascular pseudopapillary pattern with focal necrosis and subarachnoid space dissemination.
  • Tumor cells are diffusely positive for epithelial membrane antigen (EMA) and vimentin, but lack immunoreactivity for cytokeratin (CK) and glial fibrillary acidic protein (GFAP).
  • MIB-1 labeling is high, accounting for 5% of tumor focally.
  • A diagnosis of primary intraventricular cystic papillary meningioma with subarachnoid space dissemination (WHO grade III) was made.
  • To our knowledge, there is no report describing the radiological and histological characteristics of cystic papillary meningioma presenting in the lateral ventricle.
  • In addition, the biological behavior and the clinical outcome of this tumor are also discussed.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Cysts / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Magnetic Resonance Imaging. Mucin-1 / metabolism. Neoplasm Staging. Treatment Outcome. Vimentin / metabolism. Young Adult

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  • (PMID = 19307065.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Vimentin
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65. Kim EY, Weon YC, Kim ST, Kim HJ, Byun HS, Lee JI, Kim JH: Rhabdoid meningioma: clinical features and MR imaging findings in 15 patients. AJNR Am J Neuroradiol; 2007 Sep;28(8):1462-5
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  • [Title] Rhabdoid meningioma: clinical features and MR imaging findings in 15 patients.
  • BACKGROUND AND PURPOSE: Rhabdoid meningioma (RM) is a recently described variant of malignant meningioma, with radiologic features currently not well characterized in the medical literature.
  • After surgery, the patients had follow-up brain MR imaging to evaluate for tumor recurrence.
  • [MeSH-major] Magnetic Resonance Imaging. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / physiopathology. Meningioma / diagnosis. Meningioma / physiopathology
  • [MeSH-minor] Adult. Aged. Cysts / diagnosis. Edema / chemically induced. Edema / etiology. Female. Follow-Up Studies. Humans. Hyperostosis / diagnosis. Hyperostosis / etiology. Male. Middle Aged. Neurosurgical Procedures. Radiotherapy, Adjuvant. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17846191.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Fukushima S, Terasaki M, Shigemori M: Chordoid meningioma arising in the pineal region: a case report. Brain Tumor Pathol; 2008;25(2):91-5
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  • [Title] Chordoid meningioma arising in the pineal region: a case report.
  • We report a rare case of chordoid meningioma arising in the pineal region, which presented in a 22-year-old woman.
  • We performed subtotal removal of the tumor with an occipital transtentorial approach (OTA), and all her preoperative symptoms completely abated.
  • Histological examination of this tumor specimen showed the typical pattern of chordoid meningioma.
  • Chordoid meningioma has been known to correspond with Castleman's disease, and pineal meningiomas are extremely rare among intracranial meningiomas.
  • [MeSH-major] Meningioma / pathology. Pinealoma / pathology
  • [MeSH-minor] Adult. Anemia / blood. Anemia / complications. Angiography. Blood Cell Count. Blood Chemical Analysis. C-Reactive Protein / metabolism. Contrast Media. Female. Gadolinium DTPA. Headache / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Tissue Fixation

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  • (PMID = 18987835.001).
  • [ISSN] 1433-7398
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; 9007-41-4 / C-Reactive Protein; K2I13DR72L / Gadolinium DTPA
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67. Deltour I, Johansen C, Auvinen A, Feychting M, Klaeboe L, Schüz J: Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974-2003. J Natl Cancer Inst; 2009 Dec 16;101(24):1721-4
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  • [Title] Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974-2003.
  • In Denmark, Finland, Norway, and Sweden, the use of mobile phones increased sharply in the mid-1990s; thus, time trends in brain tumor incidence after 1998 may provide information about possible tumor risks associated with mobile phone use.
  • We investigated time trends in the incidence of glioma and meningioma in Denmark, Finland, Norway, and Sweden from 1974 to 2003, using data from national cancer registries.
  • We used joinpoint regression models to analyze the annual incidence rates of glioma and meningioma.
  • During this period, 59,984 men and women aged 20-79 years were diagnosed with brain tumors in a population of 16 million adults.
  • From 1974 to 2003, the incidence rate of glioma increased by 0.5% per year (95% confidence interval [CI] = 0.2% to 0.8%) among men and by 0.2% per year (95% CI = -0.1% to 0.5%) among women and that of meningioma increased by 0.8% per year (95% CI = 0.4% to 1.3%) among men, and after the early 1990s, by 3.8% per year (95% CI = 3.2% to 4.4%) among women.
  • [MeSH-major] Brain Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Denmark / epidemiology. Female. Finland / epidemiology. Glioma / epidemiology. Humans. Incidence. Male. Meningeal Neoplasms / epidemiology. Meningioma / epidemiology. Middle Aged. Norway / epidemiology. Registries. Sweden / epidemiology. Young Adult

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  • [CommentIn] J Natl Cancer Inst. 2010 May 19;102(10):740-1; author reply 742-3 [20403845.001]
  • [CommentIn] J Natl Cancer Inst. 2010 May 19;102(10):741-2; author reply 742-3 [20403846.001]
  • (PMID = 19959779.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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68. Stranjalis G, Korfias S, Psachoulia C, Boviatsis E, Kouyialis A, Protopappa D, Sakas DE: Serum S-100B as an indicator of early postoperative deterioration after meningioma surgery. Clin Chem; 2005 Jan;51(1):202-7
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  • [Title] Serum S-100B as an indicator of early postoperative deterioration after meningioma surgery.
  • BACKGROUND: S-100B protein is an established serum marker of primary and secondary brain damage in head injury and stroke.
  • Despite major progress in neurophysiologic monitoring, there are still difficulties in the early identification and quantification of evolving edema or trauma after craniotomy for tumor.
  • In this study we aimed to correlate serum S-100B values with early postoperative neurologic course as well as late outcome in meningioma surgery.
  • METHODS: We enrolled 50 consecutive patients who underwent meningioma resection.
  • In addition, multiple logistic regression showed that age, sex, site, preoperative edema, history of meningioma resection, extent of resection, and histologic type did not correlate with postoperative increases in S-100B.
  • CONCLUSIONS: After meningioma excision, postcraniotomy increases in serum S-100B appear to be an early indicator of short-term postoperative neurologic deterioration and of a poor longer-term outcome.
  • [MeSH-major] Craniotomy / adverse effects. Meningeal Neoplasms / surgery. Meningioma / surgery. Nervous System Diseases / diagnosis. S100 Proteins / blood
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Biomarkers / blood. Brain Edema / diagnosis. Brain Edema / etiology. Female. Humans. Male. Middle Aged. Nerve Growth Factors. Predictive Value of Tests. Prognosis. ROC Curve. Regression Analysis. S100 Calcium Binding Protein beta Subunit. Serum. Sex Factors

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  • (PMID = 15550475.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Nerve Growth Factors; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins
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69. Ida CM, Rodríguez FJ, Scheithauer BW, Kois N, Vanefsky M, Andersen BJ, Erickson B: Infiltrative chordoid meningioma of the pineal region: a study of 2 cases. Clin Neuropathol; 2007 May-Jun;26(3):111-8
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  • [Title] Infiltrative chordoid meningioma of the pineal region: a study of 2 cases.
  • Herein we describe two cases of chordoid meningioma with histologic evidence of pineal gland infiltration.
  • RESULTS: the patients included a 44-year-old male and a 37-year-old female who presented with symptoms of intracranial tumor referable to the pineal region.
  • Tumor cells demonstrated EMA and focal S100 protein immunoreactivity, but lacked cytokeratin AE1/AE3 and glial fibrillary acidic protein (GFAP) staining.
  • CONCLUSIONS: Chordoid meningioma, although rare, may occur in the pineal region.
  • The differential diagnosis of this meningioma subtype in this location is discussed.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Pineal Gland / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male

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  • (PMID = 19157002.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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70. Amoli FA, Mehrabani PM, Tari AS: Aggressive orbital optic nerve meningioma with benign microscopic features: a case report. Orbit; 2007 Dec;26(4):271-4
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  • [Title] Aggressive orbital optic nerve meningioma with benign microscopic features: a case report.
  • Primary optic nerve meningiomas occur at lower ages than meningiomas arising from the coverings of the brain and spinal cord.
  • Here we report the case of a 20-year-old female with an aggressive orbital meningioma referred to the Ophthalmology Department of the Farabi Hospital in Tehran.
  • The patient had a history of orbital meningioma from 10 years ago and several surgical resections due to tumor recurrence during these 10 years.
  • Fine-needle aspiration cytology of the mass confirmed tumor recurrence.
  • The patient first received radiotherapy due to the inoperable mass, and the tumor was resected 1.5 month later.
  • Microscopic study showed meningotheliomatous meningioma with extensive involvement of the optic nerve and invasion of the optic disc, sclera and choroid.
  • The interesting aspect of this case was the aggressive behavior of the tumor with intraocular invasion, despite its benign histopathological features, which led to wide exenteration of the eye together with resection of the upper and lower lids.
  • [MeSH-major] Meningioma / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 18097966.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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71. Stein PJ: A case of cerebellopontine angle meningioma presenting with neck and upper extremity pain. J Manipulative Physiol Ther; 2009 Nov-Dec;32(9):776-80
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  • [Title] A case of cerebellopontine angle meningioma presenting with neck and upper extremity pain.
  • OBJECTIVE: The purpose of this case report is to describe and discuss the clinical presentation, diagnosis, and management of a patient with a cerebellopontine angle meningioma.
  • INTERVENTION AND OUTCOME: Magnetic resonance imaging studies of the neck and brain revealed a posterior fossa tumor, which was eventually diagnosed as a benign meningioma.
  • Partial surgical removal of the tumor mass was followed by radiation therapy.
  • CONCLUSION: Patients with brain lesions may present to chiropractic practices with predominantly musculoskeletal symptoms.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / radiography. Cerebellopontine Angle / pathology. Cerebellopontine Angle / radiography. Meningioma / pathology. Meningioma / radiography. Neck / physiopathology. Pain / etiology. Pain / physiopathology. Upper Extremity / physiopathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 20004806.001).
  • [ISSN] 1532-6586
  • [Journal-full-title] Journal of manipulative and physiological therapeutics
  • [ISO-abbreviation] J Manipulative Physiol Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Saraswathy A, Jayasree RS, Baiju KV, Gupta AK, Pillai VP: Optimum wavelength for the differentiation of brain tumor tissue using autofluorescence spectroscopy. Photomed Laser Surg; 2009 Jun;27(3):425-33
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  • [Title] Optimum wavelength for the differentiation of brain tumor tissue using autofluorescence spectroscopy.
  • OBJECTIVE: The role of autofluorescence spectroscopy in the detection and staging of benign and malignant brain tumors is being investigated in this study, with an additional aim of determining an optimum excitation wavelength for the spectroscopic identification of brain tumors.
  • MATERIALS AND METHODS: The present study involves in-vitro autofluorescence monitoring of different human brain tumor samples to assess their spectroscopic properties.
  • The autofluorescence measurement at four different excitation wavelengths 320, 370, 410, and 470 nm, were carried out for five different brain tumor types: glioma, astrocytoma, meningioma, pituitary adenoma, and schwannoma.
  • RESULTS: The fluorescence spectra of tumor tissues showed significant differences, both in intensity and in spectral profile, from those of adjacent normal brain tissues at all four excitation wavelengths.
  • Of the four excitation wavelengths being considered, 470 nm appeared to be the optimal wavelength for detecting tissue fluorescence of brain tumor tissues.
  • CONCLUSIONS: In conclusion, the spectroscopic luminescence measurements carried out in this study revealed significant differences between tumor tissue and adjacent normal tissue of human brains for all the tumor types tested, except for pituitary adenoma.
  • From the results of this study we conclude that excitation wavelengths ranging from 410-470 nm are most suitable for the detection of brain tumor tissue.
  • [MeSH-major] Brain Neoplasms / pathology. Spectrometry, Fluorescence / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Algorithms. Astrocytoma / pathology. Child. Child, Preschool. Discriminant Analysis. Female. Glioma / pathology. Humans. Male. Meningioma / pathology. Middle Aged. Neoplasm Staging. Neurilemmoma / pathology. Pituitary Neoplasms / pathology. Principal Component Analysis

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  • (PMID = 19025404.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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73. Schüz J, Böhler E, Schlehofer B, Berg G, Schlaefer K, Hettinger I, Kunna-Grass K, Wahrendorf J, Blettner M: Radiofrequency electromagnetic fields emitted from base stations of DECT cordless phones and the risk of glioma and meningioma (Interphone Study Group, Germany). Radiat Res; 2006 Jul;166(1 Pt 1):116-9
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  • [Title] Radiofrequency electromagnetic fields emitted from base stations of DECT cordless phones and the risk of glioma and meningioma (Interphone Study Group, Germany).
  • The objective of this study was to test the hypothesis that exposure to continuous low-level radiofrequency electromagnetic fields (RF EMFs) increases the risk of glioma and meningioma.
  • Participants in a population-based case-control study in Germany on the risk of brain tumors in relation to cellular phone use were 747 incident brain tumor cases between the ages of 30 and 69 years and 1494 matched controls.
  • Estimated odds ratios were 0.82 (95% confidence interval: 0.29-2.33) for glioma and 0.83 (0.29-2.36) for meningioma.
  • Although the study was limited due to the small number of exposed subjects, it is still a first indication that residential low-level exposure to RF EMFs may not pose a higher risk of brain tumors.
  • [MeSH-major] Brain Neoplasms / epidemiology. Cell Phones / statistics & numerical data. Electromagnetic Fields. Environmental Exposure / statistics & numerical data. Glioma / epidemiology. Meningioma / epidemiology. Neoplasms, Radiation-Induced / epidemiology
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Female. Germany / epidemiology. Humans. Incidence. Male. Microwaves. Middle Aged. Proportional Hazards Models. Risk Assessment / methods. Risk Factors


74. Al-Khalaf HH, Lach B, Allam A, Hassounah M, Alkhani A, Elkum N, Alrokayan SA, Aboussekhra A: Expression of survivin and p16(INK4a)/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells. Brain Res; 2008 Jan 10;1188:25-34
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  • [Title] Expression of survivin and p16(INK4a)/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells.
  • Although meningiomas represent the most common class of tumors of the central nervous system, the molecular events underlying their genesis and development are still not well defined, and therapeutic approaches based on the genetics of these tumors are currently lacking.
  • In the present study we have used the immunoblotting technique to show that the p16(INK4A), Cdk6 and pRB proteins are differentially expressed in primary meningioma cells with 20-, 30- and 36-fold difference between the lowest and the highest levels of each protein, respectively.
  • Moreover, the annexin V-associated flow cytometry technique was used to show that 60% of meningioma cell cultures underwent apoptosis in response to both gamma-rays and cisplatin, and 50% of these cells exhibited significant sensitivity to hydroxyurea.
  • These data shed more light on the molecular biology of meningioma cells and suggest that survivin and proteins of the RB pathway could play a determinant role in the development and the treatment of meningiomas.
  • [MeSH-major] Apoptosis / physiology. Cyclin-Dependent Kinase 6 / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Meningeal Neoplasms / metabolism. Meningioma / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism. Retinoblastoma Protein / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / pharmacology. Cell Line, Tumor. Cisplatin / pharmacology. Female. Flow Cytometry. Humans. Hydroxyurea / pharmacology. Immunoblotting. Inhibitor of Apoptosis Proteins. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / drug effects. Proto-Oncogene Proteins c-bcl-2 / metabolism. Proto-Oncogene Proteins c-bcl-2 / radiation effects. Radiotherapy. Signal Transduction / drug effects. Signal Transduction / physiology. Up-Regulation / drug effects. Up-Regulation / physiology. Up-Regulation / radiation effects. bcl-2-Associated X Protein / drug effects. bcl-2-Associated X Protein / metabolism. bcl-2-Associated X Protein / radiation effects

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  • (PMID = 18048012.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / BIRC5 protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Retinoblastoma Protein; 0 / bcl-2-Associated X Protein; EC 2.7.11.22 / CDK6 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 6; Q20Q21Q62J / Cisplatin; X6Q56QN5QC / Hydroxyurea
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75. Apollonsky N, Edelman M, Johnson A, Bhuiya T, Karayalcin G: Intracerebral presentation of Hodgkin disease mimicking meningioma in a young woman: case presentation with literature review. J Pediatr Hematol Oncol; 2008 May;30(5):369-72
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  • [Title] Intracerebral presentation of Hodgkin disease mimicking meningioma in a young woman: case presentation with literature review.
  • Until now, 9 cases of initial presentation of the HD as a brain tumor with appropriate morphologic and histochemical confirmation were reported.
  • We describe a patient with systemic nodular sclerosing HD, who initially presented with a brain mass mimicking meningioma and was found to have disseminated lymphadenopathy and bone involvement.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / radiography. Hodgkin Disease / pathology. Hodgkin Disease / radiography. Meningioma / pathology. Meningioma / radiography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Meningeal Neoplasms / pathology. Meningeal Neoplasms / radiography

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  • (PMID = 18458571.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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76. Lönn S, Ahlbom A, Hall P, Feychting M, Swedish Interphone Study Group: Long-term mobile phone use and brain tumor risk. Am J Epidemiol; 2005 Mar 15;161(6):526-35
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  • [Title] Long-term mobile phone use and brain tumor risk.
  • The purpose of this population-based, case-control study was to test the hypothesis that long-term mobile phone use increases the risk of brain tumors.
  • The authors identified all cases aged 20-69 years who were diagnosed with glioma or meningioma during 2000-2002 in certain parts of Sweden.
  • Detailed information about mobile phone use was collected from 371 (74%) glioma and 273 (85%) meningioma cases and 674 (71%) controls.
  • For regular mobile phone use, the odds ratio was 0.8 (95% confidence interval: 0.6, 1.0) for glioma and 0.7 (95% confidence interval: 0.5, 0.9) for meningioma.
  • Furthermore, the odds ratio did not increase, regardless of tumor histology, type of phone, and amount of use.
  • This study includes a large number of long-term mobile phone users, and the authors conclude that the data do not support the hypothesis that mobile phone use is related to an increased risk of glioma or meningioma.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Glioma / etiology. Meningioma / etiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Case-Control Studies. Confidence Intervals. Female. Humans. Male. Middle Aged. Sex Distribution. Sweden / epidemiology. Time Factors

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  • [CommentIn] Am J Epidemiol. 2005 Sep 15;162(6):600-1; author reply 601 [16107569.001]
  • [CommentIn] Am J Epidemiol. 2005 Sep 15;162(6):599-600; author reply 601 [16107571.001]
  • [CommentIn] Am J Epidemiol. 2005 Sep 15;162(6):599; author reply 601 [16107570.001]
  • (PMID = 15746469.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. De Roos AJ, Rothman N, Brown M, Bell DA, Pittman GS, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD: Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro Oncol; 2006 Apr;8(2):145-55
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  • [Title] Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
  • Genes involved in phase I and phase II regulation of aromatic hydrocarbon-induced effects exhibit sequence variability that may mediate the risk of adult brain tumors.
  • We evaluated associations between gene variants in CYP1A1, CYP1B1, GSTM3, EPHX1, and NQO1 and adult brain tumor incidence.
  • Cases were patients with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96) diagnosed from 1994 to 1998 at three U.S. hospitals.
  • The CYP1B1 V432L homozygous variant was associated with decreased risk of meningioma (odds ratio [OR] = 0.6; 95% CI, 0.3-1.0) but not the other tumor types.
  • The GSTM3 *B/*B genotype was associated with increased risk of glioma (OR = 2.3; 95% CI, 1.0-5.2) and meningioma (OR = 3.6; 95% CI, 1.3-9.8).
  • The magnitude of association for GSTM3 with glioma and meningioma was greater among ever-smokers than among those who had never smoked.
  • None of the other genotypes showed consistent associations with any tumor type.

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  • (PMID = 16598069.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hydrocarbons, Aromatic; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / CYP1B1 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 1.14.14.1 / Cytochrome P-450 CYP1B1; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human; EC 3.3.2.- / Epoxide Hydrolases
  • [Other-IDs] NLM/ PMC1871937
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78. Terry MB, Howe G, Pogoda JM, Zhang FF, Ahlbom A, Choi W, Giles GG, Little J, Lubin F, Menegoz F, Ryan P, Schlehofer B, Preston-Martin S: An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group. Ann Epidemiol; 2009 Mar;19(3):161-71
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  • [Title] An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group.
  • PURPOSE: Existing studies of diet and adult brain tumors have been limited by small numbers in histology-specific subgroups.
  • Dietary data from an international collaborative case-control study on adult brain tumors were used to evaluate associations between histology-specific risk and consumption of specific food groups.
  • Of the 1548 cases, 1185 were gliomas, 332 were meningiomas, and 31 were other tumor types.
  • We also found positive associations between egg, grain, and citrus fruit consumption and glioma but not meningioma risk.
  • CONCLUSIONS: Our study suggests that selected dietary food groups may be associated with adult gliomas and its subtypes but not meningiomas.

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  • (PMID = 19216998.001).
  • [ISSN] 1873-2585
  • [Journal-full-title] Annals of epidemiology
  • [ISO-abbreviation] Ann Epidemiol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K07 CA090685; United States / NCI NIH HHS / CA / T32 CA009529; United States / NCI NIH HHS / CA / K07CA90685
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS469516; NLM/ PMC3832293
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79. Rieske P, Zakrzewska M, Biernat W, Bartkowiak J, Zimmermann A, Liberski PP: Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome. J Neurooncol; 2005 Jan;71(1):27-30
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  • [Title] Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome.
  • We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome.
  • [MeSH-major] Germ-Line Mutation. Glioblastoma / genetics. Histiocytoma, Benign Fibrous / genetics. Li-Fraumeni Syndrome / genetics. Meningioma / genetics. Neoplasms, Multiple Primary / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Brain Neoplasms / genetics. Brain Neoplasms / therapy. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 22 / genetics. DNA / analysis. Fatal Outcome. Genetic Testing. Humans. Loss of Heterozygosity. Male. Microsatellite Repeats. Skin Neoplasms / genetics. Skin Neoplasms / therapy


80. Jouanneau E, Guzman Tovar RA, Desuzinges C, Frappaz D, Louis-Tisserand G, Sunyach MP, Jouvet A, Sindou M: Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report. Neurosurgery; 2006 Apr;58(4):E789; discussion E789
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  • [Title] Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report.
  • OBJECTIVE AND IMPORTANCE: We present a rare case of very long-term medulloblastoma relapse in an adult patient and discuss the pattern of recurrence and metabolic imaging of the tumor.
  • CLINICAL PRESENTATION: A 45-year-old man was referred for evaluation of a frontobasal midline tumor 21 years after treatment of a cerebellar medulloblastoma by surgery followed by chemotherapy and craniospinal radiotherapy.
  • Magnetic resonance images were suggestive of a meningioma.
  • On diffusion imaging, the tumor appeared hyperintense, with a low apparent diffusion coefficient value of 0.689.
  • Metabolic imaging favored the diagnosis of medulloblastoma over the initially suspected diagnosis of meningioma.
  • The patient underwent complete removal of the tumor that was confirmed to be a metastasis of his primary medulloblastoma.
  • CONCLUSION: Late relapse should be considered, even after several decades, on occurrence of a second intracranial tumor in this context.
  • Our observation validates the clinical interest of preoperative metabolic imaging for brain tumors with distinctive pattern.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 16575298.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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81. Liu RS, Chang CP, Guo WY, Pan DH, Ho DM, Chang CW, Yang BH, Wu LC, Yeh SH: 1-11C-acetate versus 18F-FDG PET in detection of meningioma and monitoring the effect of gamma-knife radiosurgery. J Nucl Med; 2010 Jun;51(6):883-91
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  • [Title] 1-11C-acetate versus 18F-FDG PET in detection of meningioma and monitoring the effect of gamma-knife radiosurgery.
  • METHODS: Twenty-two patients with the neuroradiologic diagnosis of meningioma were examined by 1-(11)C-acetate and (18)F-FDG PET on the same day.
  • There were 12 cases of histopathologically proven meningioma (8 grade I, 2 grade II, and 2 grade III), 1 of tuberculous granuloma, and 1 of degenerative tissue.
  • The PET images were evaluated by a qualitative method and semiquantitative analysis using standardized uptake value and tumor-to-cortex ratio.
  • High uptake of 1-(11)C-acetate was observed in all 20 meningiomas, in contrast to the low uptake in surrounding normal brain tissue, allowing a clearer demarcation of the tumor boundary than that provided by (18)F-FDG.
  • Dissociation of regional accumulation of 1-(11)C-acetate and (18)F-FDG within the tumor was also noted on the coregistered images.
  • The standardized uptake value for 1-(11)C-acetate was not different from that for (18)F-FDG (mean +/- SD, 3.16 +/- 1.75 vs. 3.22 +/- 1.50, P = 0.601), but the tumor-to-cortex ratio for 1-(11)C-acetate was higher than that for (18)F-FDG (3.46 +/- 1.38 vs. 0.93 +/- 1.08, P < 0.005). (18)F-FDG was able to differentiate grade I from grade II-III meningiomas, whereas 1-(11)C-acetate was unable to do so.
  • Tuberculous granuloma had a high 1-(11)C-acetate and (18)F-FDG uptake similar to that of grade II/III meningioma.
  • 1-(11)C-acetate performed better than did (18)F-FDG in monitoring the response of tumor metabolism to radiosurgery.
  • CONCLUSION: 1-(11)C-acetate was found to be useful for detecting meningiomas and evaluating the extent of meningiomas and potentially useful for monitoring tumor response to radiosurgery.
  • However, 1-(11)C-acetate was not useful for evaluating the tumor grade. (18)F-FDG was found to be less useful than 1-(11)C-acetate for evaluating the extent of meningiomas and the response to radiosurgical treatment but may be useful for differentiating benign from malignant meningiomas. (18)F-FDG and 1-(11)C-acetate are complementary for assessing diverse cell metabolism of meningioma.
  • [MeSH-major] Acetates. Carbon. Fluorodeoxyglucose F18. Meningioma / radionuclide imaging. Meningioma / surgery. Positron-Emission Tomography / methods. Radiosurgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biological Transport. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Regression Analysis. Retrospective Studies. Treatment Outcome. Tumor Burden

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  • (PMID = 20484430.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetates; 0 / carbon-11 acetate; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 7440-44-0 / Carbon
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82. Jensen TR, Schmainda KM: Computer-aided detection of brain tumor invasion using multiparametric MRI. J Magn Reson Imaging; 2009 Sep;30(3):481-9
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  • [Title] Computer-aided detection of brain tumor invasion using multiparametric MRI.
  • PURPOSE: To determine the potential of using a computer-aided detection method to intelligently distinguish peritumoral edema alone from peritumor edema consisting of tumor using a combination of high-resolution morphological and physiological magnetic resonance imaging (MRI) techniques available on most clinical MRI scanners.
  • MATERIALS AND METHODS: This retrospective study consisted of patients with two types of primary brain tumors: meningiomas (n = 7) and glioblastomas (n = 11).
  • Meningiomas are typically benign and have a clear delineation of tumor and edema.
  • Four classifiers of differing designs were trained using morphological, diffusion-weighted, and perfusion-weighted features derived from MRI to discriminate tumor and edema, tested on edematous regions surrounding tumors, and assessed for their ability to detect nonenhancing tumor invasion.
  • Each classifier was able to identify areas of nonenhancing tumor invasion supported with adjunct images or follow-up studies.
  • CONCLUSION: The combination of features derived from morphological and physiological imaging techniques contains the information necessary for computer-aided detection of tumor invasion and allows for the identification of tumor invasion not previously visualized on morphological, diffusion-weighted, and perfusion-weighted images and maps.

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  • (PMID = 19711398.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA028500; United States / NCRR NIH HHS / RR / M01 RR000058; United States / NCI NIH HHS / CA / R21 CA109280; United States / NCI NIH HHS / CA / R01 CA082500; United States / NCRR NIH HHS / RR / M01-RR00058; United States / NCI NIH HHS / CA / R21 CA10928; United States / NCI NIH HHS / CA / R01 CA082500-06
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 84F6U3J2R6 / gadodiamide; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ NIHMS185656; NLM/ PMC4321878
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83. Pinarbasi H, Silig Y, Gurelik M: Genetic polymorphisms of GSTs and their association with primary brain tumor incidence. Cancer Genet Cytogenet; 2005 Jan 15;156(2):144-9
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  • [Title] Genetic polymorphisms of GSTs and their association with primary brain tumor incidence.
  • In this study, the association between polymorphisms in these genes and primary brain tumor incidence was investigated in 228 Turkish individuals (75 patients with primary brain tumor and 153 controls).
  • No association was observed between the GSTT1 or GSTP1 Ile105Val polymorphism and brain tumor incidence.
  • Polymorphisms in GSTM1, GSTT1, and GSTP1 did not show association with histopathologic type of brain tumor (glioma or meningioma).
  • Analysis of the polymorphisms in the studied genes and smoking status of the brain tumor patients revealed no statistically significant association.
  • The presented data clearly suggest a relation between brain tumor incidence with GSTM1 null genotype but not with GSTT1 or GSTP1 gene variants.
  • [MeSH-major] Brain Neoplasms / enzymology. Brain Neoplasms / genetics. Glutathione Transferase / genetics. Isoenzymes / genetics. Polymorphism, Genetic
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. DNA Primers. Female. Genetic Variation. Glutathione S-Transferase pi. Humans. Incidence. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length

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  • (PMID = 15642394.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Isoenzymes; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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84. Chen CH, Shen CC, Sun MH, Ho WL, Huang CF, Kwan PC: Histopathology of radiation necrosis with severe peritumoral edema after gamma knife radiosurgery for parasagittal meningioma. A report of two cases. Stereotact Funct Neurosurg; 2007;85(6):292-5
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  • [Title] Histopathology of radiation necrosis with severe peritumoral edema after gamma knife radiosurgery for parasagittal meningioma. A report of two cases.
  • We present 2 cases of parasagittal meningioma after GKS complicated with radiation necrosis and peritumoral edema.
  • CASE DESCRIPTION: Two cases of parasagittal meningioma received GKS.
  • Both of them underwent surgical resection of their tumor afterwards.
  • Histologic examination showed necrotic change inside the tumor and infiltration of inflammatory cells in both cases.
  • Imaging performed 3 months after surgical resection showed alleviation of brain edema.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / pathology. Meningioma / surgery. Radiation Injuries / pathology. Radiosurgery / adverse effects
  • [MeSH-minor] Adult. Brain Edema / pathology. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Necrosis

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17709982.001).
  • [ISSN] 1423-0372
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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85. Pfister C, Ritz R, Endemann E, Schittenhelm J, Bornemann A, Tatagiba MS, Roser F: Evidence of ubiquitous in vivo and in vitro expression of pro-apoptotic Smac/DIABLO protein in meningioma cell lines. Oncol Rep; 2009 May;21(5):1181-8
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  • [Title] Evidence of ubiquitous in vivo and in vitro expression of pro-apoptotic Smac/DIABLO protein in meningioma cell lines.
  • Although meningiomas are one of the most common tumors in the central nervous system, the adjuvant treatment for recurrent or malignant meningiomas is not satisfactory.
  • Changes in apoptosis mechanisms play important roles in tumor pathogenesis.
  • As Smac/DIABLO has not been previously analyzed in meningiomas, We investigated the expression of Smac/DIABLO and survivin in primary meningioma cultures in vivo and in vitro.
  • Expression of Smac/DIABLO, survivin and single-stranded (ss)DNA in vivo were determined immunohistochemically in 100 meningioma surgical specimens, dura and normal human cortex.
  • PCR analysis displayed no changes of Smac/DIABLO and survivin expression in different meningioma grades, normal human cortical cortex or dura.
  • Constant high-level Smac/DIABLO respectively low-level survivin expression in meningiomas and normal brain demonstrate similar apoptotic behavior of meningiomas compared to normal brain tissue.
  • [MeSH-major] Meningeal Neoplasms / metabolism. Meningioma / metabolism. Mitochondrial Proteins / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Intracellular Signaling Peptides and Proteins / genetics. Male. Middle Aged. RNA, Neoplasm / biosynthesis. RNA, Neoplasm / genetics. Tumor Cells, Cultured. Young Adult

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  • (PMID = 19360292.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DIABLO protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / Mitochondrial Proteins; 0 / RNA, Neoplasm
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86. Zhang MX, Zhao X, Wang ZG, Zhao WM, Wang YS: Constitutive activation of signal transducer and activator of transcription 3 regulates expression of vascular endothelial growth factor in human meningioma differentiation. J Cancer Res Clin Oncol; 2010 Jul;136(7):981-8
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  • [Title] Constitutive activation of signal transducer and activator of transcription 3 regulates expression of vascular endothelial growth factor in human meningioma differentiation.
  • The function of STAT3 in the pathogenesis of meningioma remains unknown.
  • In this study, we investigated the role of JAK1/STAT3 regulating vascular endothelial growth factor (VEGF) expression in the occurrence and progression of human meningioma.
  • METHODS: We detected the expression of JAK1, p-JAK1, STAT3, p-STAT3, and VEGF in human meningioma and normal dura tissues by RT-PCR, Western blot analysis, and immunohistochemistry.
  • RESULTS: JAK1, p-JAK1, STAT3, p-STAT3, and VEGF showed high expression in grade I and grade II meningioma.
  • The level of STAT3 activation was associated with VEGF expression; all meningioma tumors that expressed p-STAT3 also expressed VEGF.
  • Both frequency of positivity and expression were enhanced with increasing tumor grade; high frequencies and levels were found in grade II tumors, with no expression detected in normal dura tissues (P < 0.05).
  • CONCLUSIONS: VEGF is directly regulated by constitutive STAT3 activity and associated with meningioma differentiation.
  • STAT3 has an important role in the occurrence and development of human meningioma by regulating VEGF expression.
  • [MeSH-major] Janus Kinase 1 / metabolism. Meningeal Neoplasms / metabolism. Meningeal Neoplasms / pathology. Meningioma / metabolism. Meningioma / pathology. STAT3 Transcription Factor / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Blotting, Western. Disease Progression. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Young Adult

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  • (PMID = 20052595.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / Vascular Endothelial Growth Factor A; EC 2.7.010.2 / JAK1 protein, human; EC 2.7.10.2 / Janus Kinase 1
  • [Other-IDs] NLM/ PMC2874489
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87. Kashio A, Suzuki M: Bilateral hearing loss due to a meningioma located in the left posterior fossa: a case report. Acta Otolaryngol Suppl; 2007 Dec;(559):168-71
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  • [Title] Bilateral hearing loss due to a meningioma located in the left posterior fossa: a case report.
  • We report the case of a 39-year-old woman with a left side meningioma, suffering from bilateral sensorineural hearing loss, who recovered audiometric hearing in both ears after surgery.
  • After the operation, bilateral hearing loss due to a left posterior fossa meningioma gradually improved.
  • We speculate that hearing loss in the left ear may have been induced by the indirect compression of the cochlear nerve caused by the tumor's edema, whereas that in the right ear may have resulted from changes in CSF pressure caused by the mass effects of the tumor.
  • [MeSH-major] Hearing Loss, Bilateral / etiology. Hearing Loss, Sensorineural / etiology. Infratentorial Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Audiometry, Pure-Tone. Cochlea / physiopathology. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Functional Laterality / physiology. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures. Severity of Illness Index

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  • (PMID = 18340591.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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88. Kimura H, Takeuchi H, Koshimoto Y, Arishima H, Uematsu H, Kawamura Y, Kubota T, Itoh H: Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features. AJNR Am J Neuroradiol; 2006 Jan;27(1):85-93
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  • [Title] Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features.
  • PURPOSE: The goal of the present study was to determine the utility of continuous arterial spin labeling (CASL) for characterization of meningioma by MR perfusion imaging and to compare these results with those obtained from the T2 dynamic susceptibility contrast (T2DSC) method and from histopathologic examination.
  • T2DSC perfusion imaging was also performed by using a double-echo spoiled gradient echo sequence in a section containing the tumor.
  • Perfusion values were the greatest for angiomatous meningioma and lowest for fibrous meningioma when using either perfusion method.
  • Further, CASL is of use in assessing tumor microcirculation.
  • [MeSH-major] Brain / pathology. Cerebrovascular Circulation. Contrast Media. Magnetic Resonance Angiography. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Spin Labels
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blood Flow Velocity. Blood Volume. Echo-Planar Imaging. Female. Humans. Male. Middle Aged

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  • (PMID = 16418363.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Spin Labels
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89. Takei H, Adesina AM, Mehta V, Powell SZ, Langford LA: Atypical teratoid/rhabdoid tumor of the pineal region in an adult. J Neurosurg; 2010 Aug;113(2):374-9
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  • [Title] Atypical teratoid/rhabdoid tumor of the pineal region in an adult.
  • An atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal tumor most often occurring in the posterior fossa in children younger than 3 years of age.
  • Adult cases of AT/RT are very rare, and 27 cases with a diagnosis of either AT/RT or (malignant) rhabdoid tumor have been reported to date.
  • The authors report an adult case of an AT/RT occurring in the pineal region with molecular cytogenetic and immunohistochemical confirmation.
  • She underwent a subtotal resection of the tumor and was then treated with chemoradiation.
  • Histological sections showed epithelioid cellular sheets of rhabdoid tumor cells with scattered mitotic figures.
  • Immunohistochemically, the tumor cells were diffusely and strongly positive for epithelial membrane antigen and vimentin, and showed focal expression of glial fibrillary acidic protein, pancytokeratin, and neurofilament protein.
  • Histologically, this tumor consisted exclusively of epithelioid tumor cells with rhabdoid features.
  • The differential diagnoses include rhabdoid glioblastoma, metastatic carcinoma, and rhabdoid meningioma.
  • Molecular testing to identify monosomy 22 or deletions of the chromosome 22q11 containing the INI1/hSNF5 gene and/or immunohistochemical staining with INI1 antibody is of great importance for the diagnosis of this tumor.
  • [MeSH-major] Brain Neoplasms / pathology. Pinealoma / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology
  • [MeSH-minor] Adult. Biopsy. Chromosomal Proteins, Non-Histone / genetics. Chromosomes, Human, Pair 22. DNA-Binding Proteins / genetics. Female. Gene Deletion. Humans. In Situ Hybridization, Fluorescence. Magnetic Resonance Imaging. Transcription Factors / genetics

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  • (PMID = 19911885.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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90. Wigertz A, Lönn S, Schwartzbaum J, Hall P, Auvinen A, Christensen HC, Johansen C, Klaeboe L, Salminen T, Schoemaker MJ, Swerdlow AJ, Tynes T, Feychting M: Allergic conditions and brain tumor risk. Am J Epidemiol; 2007 Oct 15;166(8):941-50
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  • [Title] Allergic conditions and brain tumor risk.
  • In this large population-based case-control study, the authors identified cases diagnosed with glioma or meningioma in Denmark, Norway, Finland, Sweden, and southeast England between 2000 and 2004.
  • Detailed information on self-reported physician-diagnosed allergic conditions was collected from 1,527 glioma cases, 1,210 meningioma cases, and 3,309 randomly selected controls.
  • Meningioma risk was not associated with allergic conditions, except for eczema (odds ratio = 0.74, 95% confidence interval: 0.60, 0.91).
  • If this is etiologic, it has implications for the understanding of how allergic conditions might reduce the tumor risk.
  • [MeSH-major] Brain Neoplasms / epidemiology. Glioma / epidemiology. Hypersensitivity. Meningioma / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Aged. Case-Control Studies. Child. Denmark / epidemiology. Female. Finland / epidemiology. Great Britain / epidemiology. Humans. Logistic Models. Male. Middle Aged. Norway / epidemiology. Odds Ratio. Retrospective Studies. Risk Assessment. Risk Factors. Surveys and Questionnaires. Sweden / epidemiology

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  • (PMID = 17646205.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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91. Delgado-López PD, Martín-Velasco V, Castilla-Díez JM, Fernández-Arconada O, Corrales-García EM, Galacho-Harnero A, Rodríguez-Salazar A, Pérez-Mies B: Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature. Neurocirugia (Astur); 2006 Jun;17(3):240-9
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  • [Title] Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature.
  • To our knowledge, this is the first description of a total en bloc spondylectomy through a posterior approach for the treatment of an intraosseous metastatic meningioma to the eleventh dorsal vertebra.
  • CASE REPORT: In March 1996, a 37 year-old male underwent surgical resection for a left occipital intraventricular benign meningioma (WHO I).
  • Advice from a second pathologist was seeked, who suggested the diagnosis of intraosseous meningioma.
  • Workup studies failed to reveal any primary tumor.
  • Definite pathology: benign meningioma (WHO I).
  • Such score correlates with the chance of metastatizing: more than 40% in malignant meningiomas compared to 3.8% of brain tumors overall.
  • Hematogenous (especially venous; Batson's perivertebral plexus), linfatic and cerebrospinal fluid are the main routes involved in the spreading of the tumor.
  • [MeSH-major] Meningioma / pathology. Orthopedic Procedures / methods. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery. Thoracic Vertebrae
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Review Literature as Topic

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  • (PMID = 16855782.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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92. Hatch EE, Linet MS, Zhang J, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD: Reproductive and hormonal factors and risk of brain tumors in adult females. Int J Cancer; 2005 May 1;114(5):797-805
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  • [Title] Reproductive and hormonal factors and risk of brain tumors in adult females.
  • Causes of brain tumors are largely unknown, and there is an urgent need to identify possible risk factors.
  • Several observations point to a possible role of reproductive hormones, but few epidemiologic studies have examined whether reproductive factors, such as age at menarche and parity, are associated with brain tumor risk.
  • We conducted a multi-center case-control study of newly diagnosed glioma (n = 212) and meningioma (n = 151) and frequency-matched controls (n = 436) in women from hospitals in Phoenix, Arizona; Boston, Massachusetts; and Pittsburgh, Pennsylvania between 1994 and 1998.
  • Research nurses interviewed patients regarding potential risk factors for brain tumors, including reproductive factors and hormone use.
  • Possibly owing to low statistical power, there were few noteworthy associations between meningioma and reproductive factors, other than a nonsignificant (p = 0.09) trend of increasing risk with increasing age at menopause.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Case-Control Studies. Contraceptives, Oral / pharmacology. Female. Glioma / diagnosis. Glioma / etiology. Glioma / metabolism. Hormones / metabolism. Humans. Menarche. Meningioma / diagnosis. Meningioma / etiology. Meningioma / metabolism. Menopause. Middle Aged. Odds Ratio. Risk. Risk Factors

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  • [Copyright] 2004 Wiley-Liss, Inc.
  • (PMID = 15609304.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral; 0 / Hormones
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93. Taoka T, Yamada S, Yamatani Y, Akashi T, Miyasaka T, Emura T, Nakase H, Kichikawa K: Brain surface motion imaging to predict adhesions between meningiomas and the brain surface. Neuroradiology; 2010 Nov;52(11):1003-10
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  • [Title] Brain surface motion imaging to predict adhesions between meningiomas and the brain surface.
  • INTRODUCTION: "Brain surface motion imaging" (BSMI) is the subtraction of pulse-gated, 3D, heavily T2-weighted image of two different phases of cerebrospinal fluid (CSF) pulsation, which enables the assessment of the dynamics of brain surface pulsatile motion.
  • The purpose of this study was to evaluate the feasibility of this imaging method for providing presurgical information about adhesions between meningiomas and the brain surface.
  • METHODS: Eighteen cases with surgically resected meningioma in whom BSMI was presurgically obtained were studied.
  • We analyzed the presence of band-like texture surrounding the tumor and judged the degree of motion discrepancy as "total," "partial," or "none."
  • CONCLUSION: In the current study, BSMI could predict brain and meningioma adhesions correctly in 72.2% of cases, and adhesion location could also be predicted.
  • This imaging method appears to provide presurgical information about brain/meningioma adhesions.
  • [MeSH-major] Brain / pathology. Brain Neoplasms / pathology. Magnetic Resonance Imaging / methods. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Motion. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 20333508.001).
  • [ISSN] 1432-1920
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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94. Julià-Sapé M, Acosta D, Majós C, Moreno-Torres A, Wesseling P, Acebes JJ, Griffiths JR, Arús C: Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database. J Neurosurg; 2006 Jul;105(1):6-14
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  • [Title] Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database.
  • OBJECT: The aim of this study was to estimate the accuracy of routine magnetic resonance (MR) imaging studies in the classification of brain tumors in terms of both cell type and grade of malignancy.
  • METHODS: The authors retrospectively assessed the correlation between neuroimaging classifications and histopathological diagnoses by using multicenter database records from 393 patients with brain tumors.
  • Each tumor category was compared with the corresponding histopathological diagnoses by dichotomization.
  • In routine reporting of MR imaging examinations, tumor types and grades were classified with a high specificity (85.2-100%); sensitivity varied, depending on the tumor type and grade, alone or in combination.
  • The recognition of broad diagnostic categories (neuroepithelial or meningeal lesions) was highly sensitive, whereas when both detailed type and grade were considered, sensitivity diverged, being highest in low-grade meningioma (sensitivity 100%, 95% CI 96.2-100.0%) and lowest in high-grade meningioma (sensitivity 0.0%, 95% CI 0.0-65.8%) and low-grade oligodendroglioma (sensitivity 15%, 95% CI 5.2-36.0%).
  • This study targets the need for noninvasively increasing sensitivity in categorizing most brain tumor types while retaining high specificity, especially in the differentiation of high- and low-grade glial tumor classes.
  • [MeSH-major] Brain Neoplasms / classification. Brain Neoplasms / pathology. Magnetic Resonance Imaging. Neoplasms, Nerve Tissue / classification. Neoplasms, Nerve Tissue / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Child. Child, Preschool. Databases, Factual. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16874886.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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95. Zhu W, Mao Y, Zhou LF, Zhang R, Chen L: Combined subtemporal and retrosigmoid keyhole approach for extensive petroclival meningioma surgery: report of experience with 7 cases. Minim Invasive Neurosurg; 2007 Apr;50(2):106-10
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  • [Title] Combined subtemporal and retrosigmoid keyhole approach for extensive petroclival meningioma surgery: report of experience with 7 cases.
  • The extent of tumor resection was evaluated by MRI 3 months after surgery, and postoperative complications were investigated.
  • [MeSH-major] Cranial Fossa, Posterior / surgery. Craniotomy / methods. Infratentorial Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adult. Brain / pathology. Brain / radiography. Brain / surgery. Cavernous Sinus / anatomy & histology. Cavernous Sinus / pathology. Cavernous Sinus / surgery. Cranial Fossa, Middle / anatomy & histology. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Cranial Nerves / pathology. Cranial Nerves / physiopathology. Cranial Nerves / surgery. Dura Mater / anatomy & histology. Dura Mater / pathology. Dura Mater / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Occipital Bone / anatomy & histology. Occipital Bone / pathology. Occipital Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Treatment Outcome

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  • (PMID = 17674298.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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96. Hou BL, Bradbury M, Peck KK, Petrovich NM, Gutin PH, Holodny AI: Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex. Neuroimage; 2006 Aug 15;32(2):489-97
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  • [Title] Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex.
  • We utilized blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) and MR perfusion imaging methods to study the influence of brain tumor neovascularity on the BOLD fMRI activation volume in the primary motor cortex (PMC).
  • The results from 57 brain tumor cases demonstrated that, for grade IV gliomas only, decreases in the BOLD fMRI activation volumes within the ipsilateral PMC, when compared with that observed in the contralateral PMC, correlated with increases in the relative regional cerebral blood volume (rCBV) in the PMC.
  • These findings lend support to the hypothesis that decreases in the fMRI activation volumes adjacent to a GBM may, in part, be due to the increased contribution of aberrant tumor neovascularity, with the resultant de-coupling of blood flow from neuronal activity.
  • The nature of the relationship between the resulting activation volumes and adjacent tumor characteristics is complex, but is found to be dependent on the tumor grade and type, as well as the distance of the tumor to the PMC.
  • [MeSH-major] Astrocytoma / blood supply. Blood Volume / physiology. Brain Neoplasms / physiopathology. Glioblastoma / blood supply. Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Motor Cortex / blood supply. Neovascularization, Pathologic / physiopathology. Oligodendroglioma / blood supply. Oxygen / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Hemangiopericytoma / blood supply. Humans. Male. Meningeal Neoplasms / blood supply. Meningioma / blood supply. Middle Aged. Neurons / physiology. Regional Blood Flow / physiology. Statistics as Topic

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  • (PMID = 16806983.001).
  • [ISSN] 1053-8119
  • [Journal-full-title] NeuroImage
  • [ISO-abbreviation] Neuroimage
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] S88TT14065 / Oxygen
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97. Goldhoff P, Warrington NM, Limbrick DD Jr, Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin JB: Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res; 2008 Dec 1;14(23):7717-25
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  • [Title] Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.
  • PURPOSE: As favorable outcomes from malignant brain tumors remain limited by poor survival and treatment-related toxicity, novel approaches to cure are essential.
  • Here, we investigate the role of PDE4 in brain tumors and examine the utility of PDE4 as a therapeutic target.
  • EXPERIMENTAL DESIGN: Immunohistochemistry was used to evaluate the expression pattern of a subfamily of PDE4, PDE4A, in multiple brain tumor types.
  • To evaluate the effect of PDE4A on growth, a brain-specific isoform, PDE4A1 was overexpressed in xenografts of Daoy medulloblastoma and U87 glioblastoma cells.
  • RESULTS: We found that PDE4A is expressed in medulloblastoma, glioblastoma, oligodendroglioma, ependymoma, and meningioma.
  • Bioluminescence imaging indicated that whereas temozolomide and radiation therapy arrested intracranial tumor growth, the addition of Rolipram to this regimen resulted in tumor regression.
  • CONCLUSIONS: This study shows that PDE4 is widely expressed in brain tumors and promotes their growth and that inhibition with Rolipram overcomes tumor resistance and mediates tumor regression.

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  • (PMID = 19047098.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA094056; United States / NINDS NIH HHS / NS / P30 NS057105; United States / NCI NIH HHS / CA / P30 CA91842; United States / NCI NIH HHS / CA / P30 CA091842; United States / NCI NIH HHS / CA / R21 CA108677; United States / NCI NIH HHS / CA / P50 CA94056; United States / NCI NIH HHS / CA / P50 CA094056-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Phosphodiesterase Inhibitors; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 3.1.4.17 / Cyclic Nucleotide Phosphodiesterases, Type 4; K676NL63N7 / Rolipram
  • [Other-IDs] NLM/ NIHMS82831; NLM/ PMC2615415
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98. Kinoshita M, Goto T, Okita Y, Kagawa N, Kishima H, Hashimoto N, Yoshimine T: Diffusion tensor-based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema. J Neurooncol; 2010 Feb;96(3):409-15
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  • [Title] Diffusion tensor-based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema.
  • Among these uses, predicting the extent or existence of tumor cell invasion into white matter by DTI is under extensive investigation.
  • The previously reported tumor infiltration index (TII) holds great potential for the discrimination of pure vasogenic edema from tumor-infiltrated edema.
  • The present investigation reevaluated the utility of TII in patients with meningioma or glioma.
  • We found that TII was unable to discriminate vasogenic from tumor-infiltrated edema.
  • Conversely, detailed voxel-by-voxel comparison of TII and (11)C-methionie PET in the T2-hyperintense area of gliomas showed that TII and (11)C-methionie PET has a positive correlation, suggesting that, although TII is unable to discriminate the cause of edema, the extent of tumor cell invasion into white matter is depicted in gliomas by TII.
  • These data suggest that TII involves both vasogenic and tumor-infiltrated factors, rather than only a single factor.
  • [MeSH-major] Brain Edema / diagnosis. Brain Neoplasms / diagnosis. Glioma / diagnosis. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis
  • [MeSH-minor] Adult. Aged. Carbon Isotopes. Diffusion Tensor Imaging. Female. Humans. Image Processing, Computer-Assisted. Male. Methionine. Middle Aged. Positron-Emission Tomography / methods. Statistics as Topic. Young Adult

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  • (PMID = 19696968.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Isotopes; AE28F7PNPL / Methionine
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99. Rajaraman P, Hutchinson A, Rothman N, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Linet MS, Inskip PD: Oxidative response gene polymorphisms and risk of adult brain tumors. Neuro Oncol; 2008 Oct;10(5):709-15
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  • [Title] Oxidative response gene polymorphisms and risk of adult brain tumors.
  • Oxidative stress is believed to play a key role in tumor formation.
  • Although this mechanism could be especially pertinent for brain tumors given the high oxygen consumption of the brain, very little has been published regarding brain tumor risk with respect to genes mediating oxidative stress.
  • Using data from non-Hispanic whites in a hospital-based case-control study conducted by the National Cancer Institute between 1994 and 1998, we evaluated risk of glioma (n=362), meningioma (n=134), and acoustic neuroma (n=69) compared to noncancer controls (n=494) with respect to nine single nucleotide polymorphisms from seven genes involved in oxidative stress response (CAT, GPX1, NOS3, PON1, SOD1, SOD2, and SOD3).
  • We observed increased risk of glioma (odds ratio [OR](CT/CC)=1.3; 95% confidence interval [95% CI], 1.0-1.7) and meningioma (OR(CT/CC)=1.7; 95% CI, 1.1-2.7) with the C variant of SOD3 rs699473.
  • Our results suggest that common variants in the SOD2, SOD3, and CAT genes may influence brain tumor risk.
  • [MeSH-major] Brain Neoplasms / genetics. Catalase / genetics. Oxidative Stress / genetics. Polymorphism, Single Nucleotide / genetics. Superoxide Dismutase / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Genetic Predisposition to Disease. Humans. Male. Middle Aged

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  • (PMID = 18682580.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / N01CO12400; United States / NCI NIH HHS / CO / N01-CO-12400; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.11.1.6 / Catalase; EC 1.15.1.1 / SOD3 protein, human; EC 1.15.1.1 / Superoxide Dismutase; EC 1.15.1.1 / superoxide dismutase 2
  • [Other-IDs] NLM/ PMC2666247
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100. van Westen D, Lätt J, Englund E, Brockstedt S, Larsson EM: Tumor extension in high-grade gliomas assessed with diffusion magnetic resonance imaging: values and lesion-to-brain ratios of apparent diffusion coefficient and fractional anisotropy. Acta Radiol; 2006 Apr;47(3):311-9
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  • [Title] Tumor extension in high-grade gliomas assessed with diffusion magnetic resonance imaging: values and lesion-to-brain ratios of apparent diffusion coefficient and fractional anisotropy.
  • PURPOSE: To determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema in gliomas from pure edema in meningiomas and metastases.
  • ADC and FA were determined from ROIs placed in peritumoral areas with T2-signal changes, adjacent normal appearing white matter (NAWM), and corresponding areas in the contralateral healthy brain.
  • Values and lesion-to-brain ratios from gliomas were compared to those from meningiomas and metastases.
  • RESULTS: Values and lesion-to-brain ratios of ADC and FA in peritumoral areas with T2-signal changes did not differ between gliomas, meningiomas, and metastases (P = 0.40, P = 0.40, P = 0.61, P = 0.34).
  • Values of ADC and FA and the lesion-to-brain ratio of FA in the adjacent NAWM did not differ between tumor types (P = 0.74, P = 0.25, and P = 0.31).
  • The lesion-to-brain ratio of ADC in the adjacent NAWM was higher in gliomas than in meningiomas and metastases (P = 0.004), but overlapped between tumor types.
  • CONCLUSION: Values and lesion-to-brain ratios of ADC and FA in areas with T2-signal changes surrounding intracranial tumors and adjacent NAWM were not helpful for distinguishing pure edema from tumor-infiltrated edema when data from gliomas, meningiomas, and metastases were compared.
  • [MeSH-major] Brain Edema / pathology. Brain Neoplasms / pathology. Diffusion Magnetic Resonance Imaging. Glioma / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adult. Aged. Anisotropy. Diagnosis, Differential. Diffusion. Female. Humans. Male. Middle Aged. Prospective Studies

  • MedlinePlus Health Information. consumer health - Brain Tumors.
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  • [CommentIn] Acta Radiol. 2006 Apr;47(3):230 [16613301.001]
  • (PMID = 16613314.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
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