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1. Liu BG, Qi ST, Pan J, Peng YP, Fang LX: [Growth of craniopharyngioma involving the third ventricular floor in relation to the hypothalamus]. Nan Fang Yi Ke Da Xue Xue Bao; 2007 Mar;27(3):377-9
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  • [Title] [Growth of craniopharyngioma involving the third ventricular floor in relation to the hypothalamus].
  • OBJECTIVE: To investigate the growth of craniopharyngioma involving the third ventricular floor with regard to the hypothalamus by detecting expressions of leukocyte common antigen (CD45) and intercellular adhesion molecule (ICAM-1) in the tumor tissue.
  • METHODS: The expressions of CD45 and ICAM-1 proteins in 30 craniopharyngioma samples with third ventricular floor involvement were detected by SP immunohistochemistry.
  • RESULTS: The inflammations labeled by CD45 were identified commonly in the craniopharyngioma tissues involving the third ventricular floor.
  • The expression of ICAM-1 was mainly in the inner tumor cells and interstitial cells, but not detected in the basilar tumor cells growing toward the third ventricular floor.
  • Adamantinomatous craniopharyngiomas showed markedly higher CD45 and ICAM-1 expressions than squamous papillary tumors (P<0.05).
  • CONCLUSION: Inflammatory adhesion largely characterizes the growth of the craniopharyngioma tissues involving the third ventricular floor toward the hypothalamus without the tendency of invasion.
  • The difference in the inflammation between the two types of craniopharyngioma may affect the prognosis of the patients.
  • [MeSH-major] Craniopharyngioma / pathology. Hypothalamus / pathology. Pituitary Neoplasms / pathology. Third Ventricle
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD45 / biosynthesis. Brain Neoplasms / metabolism. Brain Neoplasms / secondary. Child. Female. Humans. Immunohistochemistry. Intercellular Adhesion Molecule-1 / biosynthesis. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17425998.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 126547-89-5 / Intercellular Adhesion Molecule-1; EC 3.1.3.48 / Antigens, CD45
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2. Dekkers OM, Biermasz NR, Smit JW, Groot LE, Roelfsema F, Romijn JA, Pereira AM: Quality of life in treated adult craniopharyngioma patients. Eur J Endocrinol; 2006 Mar;154(3):483-9
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  • [Title] Quality of life in treated adult craniopharyngioma patients.
  • A reduced QoL has been reported in childhood-onset craniopharyngioma; however, reports of QoL in adult craniopharyngioma patients are scarce.
  • In the present study, we assessed QoL in adult patients successfully treated for craniopharyngioma in our centre.
  • METHODS: In this study, we assessed QoL in 29 adult patients in remission during long-term follow-up after treatment for craniopharyngioma.
  • CONCLUSION: Adult patients treated for craniopharyngioma show persistent impairment in QoL, especially in the physical subscales.

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  • (PMID = 16498063.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Jha AN, Rahmathulla G, Vaishya S, Walia BS, Gupta V: Intraoperative high field magnetic resonance imaging in neurosurgery: our initial experience with the brain suite. Neurol India; 2007 Apr-Jun;55(2):169-72
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  • [Title] Intraoperative high field magnetic resonance imaging in neurosurgery: our initial experience with the brain suite.
  • 11 patients were operated on from June 1st to August 1st 2006 of which there were astrocytomas (7), pituitary adenoma (1), craniopharyngioma (1) and meningiomas (2) Localization and lesion targeting were accurate, intra-operative imaging helped to assess the resection volumes, enable corrections for brain shift, perform further tumor resection at the same sitting and help preserve eloquent cortical areas.
  • One pituitary adenoma and a craniopharyngioma were also operated on with good outcome.
  • [MeSH-major] Brain / pathology. Brain / surgery. Magnetic Resonance Imaging. Neurosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Brain Neoplasms / pathology. Brain Neoplasms / surgery. Female. Glioma / pathology. Glioma / surgery. Humans. Intraoperative Period. Male. Meningioma / pathology. Meningioma / surgery. Middle Aged. Pituitary Gland / pathology. Pituitary Gland / surgery

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  • (PMID = 17558127.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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4. Kasuya H, Matsumoto M, Munakata R, Muramatsu H, Ichikawa T, Sato T, Endo Y, Sakuma J, Suzuki K, Sasaki T, Kodama N: Separate demonstration of arterial- and venous-phase by 3D-CT angiography for brain tumors using 64-multidetector row CT: 3D-CT arteriography and 3D-CT venography. Fukushima J Med Sci; 2009 Jun;55(1):7-22
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  • [Title] Separate demonstration of arterial- and venous-phase by 3D-CT angiography for brain tumors using 64-multidetector row CT: 3D-CT arteriography and 3D-CT venography.
  • We assessed the usefulness of the separate demonstration of the arterial- and venous phase on 3D-CT angiography (3D-CTA) using a 64-multidetector row CT (MDCT) scanner for the surgery of brain tumors.
  • Nineteen patients with meningiomas (n=11), schwannomas, metastatic brain tumors (n=2 each), glioblastoma multiforme, malignant lymphoma, craniopharyngioma, and embryonal carcinoma (n=1 each) underwent scanning on a 64-MDCT scanner.
  • The 3D-CT arteriographs, 3D-CT venographs, and the fused 3D-CT images facilitated our understanding of the 3D anatomic relationship among the tumor, arteries, veins, and bony structures.
  • In 14 of 19 cases our method provided the surgically valuable findings; the information on the anatomical relation between tumor and the surrounding arteries and veins (in 13 cases) the identification of anatomical course of the encased vessels (in one), and feeding arteries and draining veins (in one), and discrimination between the venous sinus and tumor (in one).
  • [MeSH-major] Brain Neoplasms / radiography. Imaging, Three-Dimensional / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Angiography / methods. Arteries. Female. Humans. Male. Middle Aged. Phlebography / methods. Veins

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  • (PMID = 19999165.001).
  • [ISSN] 0016-2590
  • [Journal-full-title] Fukushima journal of medical science
  • [ISO-abbreviation] Fukushima J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Japan
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5. Hargrave DR, Hargrave UA, Bouffet E: Quality of health information on the Internet in pediatric neuro-oncology. Neuro Oncol; 2006 Apr;8(2):175-82
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  • The Internet is now the single largest source of health information and is used by many patients and their families who are affected by childhood brain tumors.
  • To assess the quality of pediatric neuro-oncology information on the Internet, we used search engines to look for information on five common tumor types (brain stem glioma, craniopharyngioma, ependymoma, low-grade glioma, and medulloblastoma).
  • Few sites offered information in languages other than English, and readability statistics showed an average required reading level of U.S. grade 12+ (the suggested level being grades 6-8 for an adult audience).
  • [MeSH-major] Brain Neoplasms. Internet / standards. Medical Informatics / standards. Medical Oncology. Neurology

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  • (PMID = 16533758.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1871939
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6. Schittenhelm J, Psaras T, Meyermann R, Honegger J, Beschorner R: Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. Folia Neuropathol; 2010;48(2):75-80
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  • [Title] Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms.
  • While many neoplasms have been studied, to date, no data is available on CDX2 expression in craniopharyngiomas.
  • MATERIAL AND METHODS: We investigated CDX2 expression in 28 normal pituitary glands, 75 pituitary adenomas of varying hormonal activity (including 7 invasive adenomas and 7 atypical adenomas) and 23 craniopharyngiomas (17 adamantinous and 6 papillary) in tissue microarrays.
  • RESULTS: None of the pituitary adenomas, craniopharyngiomas and normal pituitary glands showed expression of CDX2.
  • CONCLUSIONS: There is no evidence for that CDX2 might play a role in tumourigenesis, invasive growth or tumour recurrence of pituitary adenomas or in tumourigenesis of craniopharyngiomas.

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  • (PMID = 20602288.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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7. Shi XE, Wu B, Fan T, Zhou ZQ, Zhang YL: Craniopharyngioma: surgical experience of 309 cases in China. Clin Neurol Neurosurg; 2008 Feb;110(2):151-9
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  • [Title] Craniopharyngioma: surgical experience of 309 cases in China.
  • OBJECTIVE: The objective of the present study was to retrospectively review the surgical outcome of 309 craniopharyngioma cases treated by a single neurosurgeon in China.
  • PATIENTS AND METHODS: A total of 309 cases of craniopharyngioma that were treated surgically from January 1996 to May 2006.
  • The tumor size varied in diameter from 2.0 cm to 9.0 cm (mean 34.5 mm).
  • In the 167 patients with total tumor removal, 23 (13.7%) had tumor recurrence within an average of 1.8 years.
  • CONCLUSION: Pre-surgery neuroimaging evaluations have improved our knowledge of intricate anatomical relationship between craniopharyngioma and the structures of the hypothalamus, pituitary stalk, and optic apparatus, which make total tumor resection feasible with the preservation of these vital structures to ensure a lower recurrence rate with acceptable mortality.
  • However, excessive long-term morbidity, mostly related to hypopituitarism, which leads to the poor quality of life for the craniopharyngioma patients, is still remained.
  • Further effort should be invested to monitor and maintain the normal hormone levels, hence improve the quality of life for craniopharyngioma patients.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. China. Cohort Studies. Female. Humans. Hypophysectomy. Infant. Male. Microsurgery. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 18063470.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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8. Kim SD, Park JY, Park J, Lee JB, Kim SH, Lim DJ: Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma. Clin Neurol Neurosurg; 2007 Apr;109(3):236-41
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  • [Title] Radiological findings following postsurgical intratumoral bleomycin injection for cystic craniopharyngioma.
  • OBJECTIVES: The purpose of this study was to compare the radiological findings before and after intratumoral bleomycin injection in patients with cystic craniopharyngioma so as to define the role of adjuvant intracavitary bleomycin chemotherapy for cystic craniopharyngiomas.
  • PATIENTS AND METHODS: Eleven patients whose craniopharyngioma was confirmed cytologically and/or histologically were retrospectively reviewed.
  • Only the solid portion of the cystic craniopharyngiomas was excised before repeated injections of bleomycin (15-180 mg in total) into the cystic portion through an Ommaya reservoir were given.
  • RESULTS: After the completion of all treatment cycles, the disappearance or shrinkage of the tumor was initially noted in all cases on follow-up CT and/or MR imaging studies.
  • However, tumor recurrence was seen in four cases with a mixed tumor type.
  • CONCLUSION: Postoperative bleomycin injection in cystic craniopharyngioma does not appear to totally eradicate the tumor and does not stop tumor recurrence unless the cyst is the only portion of the craniopharyngioma that is left.
  • Nevertheless, postoperative bleomycin injection decreases and stabilizes tumor size, and thus may be considered as an option of treatment modalities in patients with predominantly cystic craniopharyngiomas.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Craniopharyngioma. Cysts. Magnetic Resonance Imaging. Pituitary Neoplasms. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Brain / pathology. Brain / radiography. Brain / surgery. Child. Combined Modality Therapy. Female. Humans. Injections. Male. Middle Aged. Neurosurgical Procedures. Postoperative Care

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  • (PMID = 17046151.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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9. Massengale J, Tafti BA, Large L, Skirboll S: Reversal of preoperative catatonic state by surgical resection of an adult-onset craniopharyngioma: case report and review of the literature. Cogn Behav Neurol; 2009 Mar;22(1):67-71
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  • [Title] Reversal of preoperative catatonic state by surgical resection of an adult-onset craniopharyngioma: case report and review of the literature.
  • OBJECTIVE: To describe a case of a rare adult-onset craniopharyngioma presenting as rapidly progressive catatonia that was reversed after surgical resection of the tumor.
  • CONCLUSIONS: The search for an etiology of a profound catatonic state should include the probability of a suprasellar/hypothalamic lesion, which in this case was owing to the rare finding of an imaging-documented adult-onset craniopharyngioma.
  • [MeSH-major] Catatonia / therapy. Craniopharyngioma / complications. Craniopharyngioma / surgery. Neurosurgical Procedures. Pituitary Neoplasms / complications. Pituitary Neoplasms / surgery
  • [MeSH-minor] Brain / pathology. Hormones / blood. Humans. Hypnotics and Sedatives / therapeutic use. Lorazepam / therapeutic use. Male. Middle Aged. Psychotic Disorders / complications. Psychotic Disorders / psychology

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  • (PMID = 19372773.001).
  • [ISSN] 1543-3641
  • [Journal-full-title] Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
  • [ISO-abbreviation] Cogn Behav Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hormones; 0 / Hypnotics and Sedatives; O26FZP769L / Lorazepam
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10. Park YS, Ahn JY, Kim DS, Kim TS, Kim SH: Late development of craniopharyngioma following surgery for Rathke's cleft cyst. Clin Neuropathol; 2009 May-Jun;28(3):177-81
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  • [Title] Late development of craniopharyngioma following surgery for Rathke's cleft cyst.
  • OBJECTIVE: Rathke's cleft cyst (RCC) may transform to papillary type craniopharyngioma (CP) after squamous metaplasia: this is referred to as ciliated CP.
  • 34 months after the initial surgery, the patient revisited our hospital for a rapidly aggravating visual disturbance and underwent neuroendoscopic biopsy and tumor removal via a bifrontal craniotomy.
  • Histologically, the tumor was shown to be an adamantinomatous CP.
  • [MeSH-major] Central Nervous System Cysts / pathology. Craniopharyngioma / pathology. Neoplasms, Second Primary / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. beta Catenin / metabolism

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  • (PMID = 19537134.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / beta Catenin
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11. Bianco Ade M, Madeira LV, Rosemberg S, Shibata MK: Cortical seeding of a craniopharyngioma after craniotomy: Case report. Surg Neurol; 2006 Oct;66(4):437-40; discussion 440
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  • [Title] Cortical seeding of a craniopharyngioma after craniotomy: Case report.
  • BACKGROUND: Cortical seeding of a craniopharyngioma has been rarely reported.
  • METHODS: A 27-year-old woman presented earlier with a suprasellar craniopharyngioma.
  • A left frontotemporal craniotomy was done with subtotal resection of the tumor because it was strongly adhered to the optic chiasm.
  • Histopathology confirmed the diagnosis of craniopharyngioma.
  • Magnetic resonance imaging revealed a contrast-enhancing tumor with cystic and solid components on the left temporal lobe cortex.
  • The primary tumor bed was intact.
  • The patient was reoperated, and the temporal lobe tumor was totally removed.
  • Histologic studies showed an adamantinomatous craniopharyngioma.
  • CONCLUSIONS: Although craniopharyngiomas exhibit a benign histopathologic pattern, a total resection combined with careful inspection and irrigation of the surgical field is the optimal treatment for preventing local and ectopic recurrences.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Seeding. Pituitary Neoplasms / pathology. Temporal Lobe / pathology
  • [MeSH-minor] Adult. Craniotomy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Optic Chiasm / pathology. Optic Chiasm / physiopathology. Seizures / etiology. Seizures / physiopathology. Treatment Outcome. Vision, Low / etiology. Vision, Low / physiopathology

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  • (PMID = 17015135.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Romani R, Niemelä M, Celik O, Isarakul P, Paetau A, Hernesniemi J: Ectopic recurrence of craniopharyngioma along the surgical route: case report and literature review. Acta Neurochir (Wien); 2010 Feb;152(2):297-302; discussion 302
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  • [Title] Ectopic recurrence of craniopharyngioma along the surgical route: case report and literature review.
  • We present a 22-year-old woman with an ectopic recurrence of a craniopharyngioma.
  • The patient presented first with a visual field deficit, and a craniopharyngioma was removed via an interhemispheric transcallosal approach.
  • However, at 4 years, MRI showed the presence of a small tumor in the right medial frontal lobe attached to the falx and along the previous surgical route.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Seeding. Pituitary Neoplasms / pathology
  • [MeSH-minor] Choristoma / pathology. Choristoma / physiopathology. Choristoma / surgery. Corpus Callosum / anatomy & histology. Corpus Callosum / surgery. Dura Mater / pathology. Dura Mater / surgery. Female. Frontal Lobe / pathology. Frontal Lobe / surgery. Humans. Magnetic Resonance Imaging. Neoplasm Metastasis / pathology. Neoplasm Metastasis / therapy. Neurosurgical Procedures. Pituitary Gland / pathology. Pituitary Gland / surgery. Postoperative Complications / pathology. Postoperative Complications / surgery. Sella Turcica / pathology. Sella Turcica / surgery. Treatment Outcome. Young Adult

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  • (PMID = 19499168.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 29
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13. Brown JL, Burton DW, Deftos LJ, Smith AA, Pincus DW, Haller MJ: Congenital craniopharyngioma and hypercalcemia induced by parathyroid hormone-related protein. Endocr Pract; 2007 Jan-Feb;13(1):67-71
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  • [Title] Congenital craniopharyngioma and hypercalcemia induced by parathyroid hormone-related protein.
  • OBJECTIVE: To report a case of congenital craniopharyngioma and parathyroid hormone-related protein (PTHrP)-associated humoral hypercalcemia.
  • METHODS: Details of this unusual case are reviewed, from detection of fetal hydrocephalus and a brain tumor, through cesarean delivery at 36 weeks of gestation, to subsequent laboratory studies, management, and confirmation of the diagnosis.
  • RESULTS: Although PTHrP has been well documented as a cause of humoral hypercalcemia of malignancy (HHM) in adult patients with cancer, HHM is uncommon in children.
  • To the best of our knowledge, we report the first case of a neonate with congenital craniopharyngioma and refractory hypercalcemia (peak ionized calcium level of 1.92 mmol/L; normal, 1.05 to 1.3) attributed to an elevated PTHrP value of 8.6 pmol/L (normal, less than 4.7).
  • CONCLUSION: The diagnosis of craniopharyngioma was confirmed at autopsy, and immunohistochemical studies substantiated that the craniopharyngioma produced PTHrP.
  • [MeSH-major] Craniopharyngioma / congenital. Craniopharyngioma / metabolism. Hypercalcemia / etiology. Parathyroid Hormone-Related Protein / metabolism. Pituitary Neoplasms / congenital. Pituitary Neoplasms / metabolism
  • [MeSH-minor] Adult. Calcium / blood. Fatal Outcome. Female. Humans. Infant, Newborn. Magnetic Resonance Imaging. Pregnancy. Prenatal Diagnosis

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  • (PMID = 17360305.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein; SY7Q814VUP / Calcium
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14. Kyrgiannis K, Mourgela S, Karamanakos PN, Liaropoulos K, Papadakis N: Optimal treatment of a recurrent giant craniopharyngioma: lessons from a case. J BUON; 2008 Oct-Dec;13(4):593-6
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  • [Title] Optimal treatment of a recurrent giant craniopharyngioma: lessons from a case.
  • A case of a 33-year-old man presented with symptoms of dramatic deterioration of the level of consciousness because of a recurrence of a previously aspirated and irradiated craniopharyngioma is described.
  • The tumor had grown enormously in dimensions and was extending in the region of hypothalamus, third ventricle and brain stem, with signs of local compression and obstructive hydrocephalus.
  • We conclude that in expert hands, microsurgery aiming at total removal should be the therapeutic option for the treatment of recurrent as well as primary craniopharyngiomas.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 19145689.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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15. Tena-Suck ML, Moreno-Reyes I, Rembao D, Vega R, Moreno-Jiménez S, Castillejos-López Mde J, Fernández-Plata R, Martínez-Briseño D, Salinas-Lara C: [Clinical pathological study of craniopharyngioma. Fifteen years at the National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez"]. Gac Med Mex; 2009 Sep-Oct;145(5):361-8
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  • [Title] [Clinical pathological study of craniopharyngioma. Fifteen years at the National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez"].
  • [Transliterated title] Craneofaringioma, estudio clínico-patológico. Quince años del Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez".
  • BACKGROUND: Craniopharyngioma is a sellar region benign cyst It's frequency ranges from 1.2% to 4.6% of all brain tumors.
  • OBJECTIVE: To carry out a clinical pathological correlation of craniopharyngioma among adults and describe the tumor's biological characteristics.
  • METHODS: We included 115 craniopharyngiomas; 100 were adamantimomatous and 15 were papillary type.
  • Follow-up was longer among females than males and in suprasellar tumor location, papillary type, external epithelium cysts and laxo stellate reticulum.
  • CONCLUSIONS: However a good prognostic factor in craniopharyngiomas was observed in older female patients with complete exeresis, small tumors, external epithelium cysts, edematous stroma, inflammation, and absence of atypical cell and mitosis.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20073441.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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16. Burghaus S, Hölsken A, Buchfelder M, Fahlbusch R, Riederer BM, Hans V, Blümcke I, Buslei R: A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch; 2010 Mar;456(3):287-300
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  • [Title] A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.
  • Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants.
  • Both subtypes are classified according to the World Health Organization grade I, but their irregular digitate brain infiltration makes any complete surgical resection difficult to obtain.
  • Herein, we characterized the cellular interface between the tumor and the surrounding brain tissue in 48 CP (41 adaCP and seven papCP) compared to non-neuroepithelial tumors, i.e., 12 cavernous hemangiomas, 10 meningiomas, and 14 metastases using antibodies directed against glial fibrillary acid protein (GFAP), vimentin, nestin, microtubule-associated protein 2 (MAP2) splice variants, and tenascin-C.
  • Furthermore, the outer tumor cell layer of adaCP showed a distinct expression of MAP2, a novel finding helpful in the differential diagnosis of epithelial tumors in the sellar region.
  • Our data support the hypothesis that adaCP, unlike other non-neuroepithelial tumors of the central nervous system, create a tumor-specific cellular environment at the tumor-brain junction.
  • [MeSH-major] Craniopharyngioma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Brain / metabolism. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Nerve Tissue Proteins / metabolism. Nestin. Tenascin / metabolism. Vimentin / metabolism

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  • (PMID = 20069432.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Tenascin; 0 / Vimentin
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17. Jiang ZL, Ren XH, Chu JS, Lin S, Zhang MZ: [Microsurgical treatment of adult craniopharyngiomas in 156 cases]. Zhonghua Yi Xue Za Zhi; 2010 Feb 2;90(5):291-4
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  • [Title] [Microsurgical treatment of adult craniopharyngiomas in 156 cases].
  • OBJECTIVE: To explore the clinical features, surgical approaches and outcomes of craniopharyngioma in adults.
  • METHODS: A total of 156 cases of adult craniopharyngioma underwent microsurgery at our hospital were retrospectively reviewed and classified into four types according to the location of tumor relative to sellar diaphragm and the third ventricle.
  • 75.3% of the cases were capable of normal work and life and tumor recurred in 26 cases.
  • CONCLUSION: Selection of appropriate approach is the key to successful microsurgery for craniopharyngioma according to the site and growth pattern of tumor.
  • [MeSH-major] Craniopharyngioma / surgery. Microsurgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20368046.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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18. Bardakci F, Arslan S, Bardakci S, Binatli AO, Budak M: Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors. J Cancer Res Clin Oncol; 2008 Jan;134(1):109-14
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  • [Title] Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors.
  • The present study has investigated the association between SULT1A1 polymorphism and primary brain tumor incidence.
  • METHODS: SULT1A1 genotypes were successfully detected using the PCR-RFLP assay in 60 primary brain tumor patients and 156 hospital-based healthy control individuals with no history of cancer or precancerous disorder.
  • RESULTS: There was a significant difference in genotypes distribution (GG vs. GA + AA) between brain tumor patients (GG genotype frequency = 48.3%) and control population (GG genotype frequency = 65.4%; OR = 2.019, 95% CI = 1.103-3.695; P = 0.022).
  • In order to determine the association between SULT1A1 polymorphism and specific types of brain tumors, the patients were classified according to the type of brain tumors they suffer from: glial and non-glial.
  • Results of the statistical analyses of each group of patients in comparison with the control individuals showed a significant difference only between SULT1A1 polymorphism and non-glial brain tumors (OR = 2.615; 95% CI = 1.192-5.739; P = 0.014) but glial tumors (OR = 1.535; 95% CI = 0.688-3.425; P = 0.293).
  • When non-glial tumors were classified as meningiomal and others (pituitary adenoma, craniopharyngioma, acoustic neuroma and hemangioblastoma), statistical analysis showed that this significance is only due to the meningiomal tumors (OR = 3.238; CI = 1.205-8.704; P = 0.015).
  • We also estimated a reduced risk of brain tumor in non-smokers (OR = 1.700; CI = 0.800-3.615) in comparison to smokers (OR = 2.773; CI = 0.993-7.749), but this was not statistically significant.
  • CONCLUSION: Our findings have suggested that there was a significant association between brain tumor and SULT1A1*2 allele (A allele that is also known as His allele) and this allele is an important risk factor in the development of meningiomal brain tumors.
  • [MeSH-major] Arylsulfotransferase / genetics. Brain Neoplasms / genetics. Genetic Predisposition to Disease. Polymorphism, Genetic
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Alleles. Case-Control Studies. Child. Child, Preschool. Craniopharyngioma / enzymology. Craniopharyngioma / genetics. Craniopharyngioma / pathology. Female. Hemangioblastoma / enzymology. Hemangioblastoma / genetics. Hemangioblastoma / pathology. Humans. Infant. Male. Meningioma / enzymology. Meningioma / genetics. Meningioma / pathology. Middle Aged. Neuroma, Acoustic / enzymology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology. Pituitary Neoplasms / enzymology. Pituitary Neoplasms / genetics. Pituitary Neoplasms / pathology. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length. Prognosis. Risk Factors. Turkey / epidemiology

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  • (PMID = 17605044.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.8.2.1 / Arylsulfotransferase; EC 2.8.2.1 / SULT1A1 protein, human
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19. Linnert M, Gehl J: Bleomycin treatment of brain tumors: an evaluation. Anticancer Drugs; 2009 Mar;20(3):157-64
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  • [Title] Bleomycin treatment of brain tumors: an evaluation.
  • Bleomycin has been used in the treatment of brain tumors for over 30 years.
  • Currently, we are evaluating electrochemotherapy (the use of electric pulses to enhance uptake of bleomycin) for patients with secondary brain tumors.
  • Using the keywords 'brain' and 'bleomycin', a database search without date restriction was performed and over 500 articles were found.
  • Twenty-five articles were used for this study based on relevance determined by: (i) clinical studies, (ii) use of bleomycin, and (iii) direct injection into brain tissue or cysts.
  • There were two main indications for the use of bleomycin directly into the brain: (i) cystic tumors in the form of craniopharyngiomas and (ii) solid brain tumors such as glioblastomas and astrocytomas.
  • All cases with severe and moderate adverse effects except one were patients with craniopharyngiomas and probably because of tumor localization in the deep brain.
  • In conclusion, bleomycin injection into the brain has been fairly well tolerated at doses much higher than that used in electrochemotherapy.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Brain Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Blindness / chemically induced. Brain Edema / chemically induced. Child. Child, Preschool. Craniopharyngioma / drug therapy. DNA Damage. Deafness / chemically induced. Electroporation. Female. Glioma / drug therapy. Humans. Infant. Injections, Spinal. Male. Middle Aged. Pituitary Neoplasms / drug therapy. Young Adult

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  • (PMID = 19396014.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 11056-06-7 / Bleomycin
  • [Number-of-references] 43
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20. Xu J, Zhang S, You C, Huang S, Cai B, Wang X: Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. J Neurooncol; 2007 Jun;83(2):183-9
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  • [Title] Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.
  • Craniopharyngioma often recurs after resection resulting in poor outcome for the affected patients.
  • The reliable criteria for predicting the tumor behavior are still lacking.
  • It has been suggested that proliferative potential of the tumor cells is necessary for recurrence.
  • Present study evaluated the cell multiplication activity, which is possibly related to relapse in 32 patients with adamantine epithelioma (AE) and 31 patients with squamous papillary tumor (SP).
  • For this tissue specimens from their primary and recurring tumors were collected and immunohistochemical analysis of the expression of minichromosome maintenance protein 6 (MCM6) and DNA topoisomerase II alphalpha (DNA Topo II alpha) in the tumor sections was performed by quantitative microscopy.
  • There was a strong linear positive correlation between MCM6 LI and DNA Topo II alpha LI (r = 0.713; p = 0.000) in the craniopharyngiomas studied.
  • The median MCM6 LI of the total 20 recurrent craniopharyngiomas (31.49%) was not significantly different from that of their primary tumors (29.65%).
  • The long term risk of tumor recurrence is higher in AE than SP and it is associated with MCM6 and DNA Topo II alpha expression.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Brain Neoplasms / metabolism. Cell Cycle Proteins / metabolism. Craniopharyngioma / metabolism. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Neoplasm Recurrence, Local / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Proliferation. Child. Child, Preschool. Cohort Studies. Female. Humans. Immunohistochemistry. Male. Matched-Pair Analysis. Middle Aged. Minichromosome Maintenance Complex Component 6. Prospective Studies

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  • (PMID = 17410335.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; EC 3.6.4.12 / MCM6 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 6; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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21. Jung TY, Jung S, Choi JE, Moon KS, Kim IY, Kang SS: Adult craniopharyngiomas: surgical results with a special focus on endocrinological outcomes and recurrence according to pituitary stalk preservation. J Neurosurg; 2009 Sep;111(3):572-7
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  • [Title] Adult craniopharyngiomas: surgical results with a special focus on endocrinological outcomes and recurrence according to pituitary stalk preservation.
  • OBJECT: The aim of this study was to evaluate the results of surgical treatment of adult craniopharyngioma with a special focus on the endocrinological outcomes and tumor recurrence in cases of pituitary preservation.
  • METHODS: Between 1993 and February 2008, 41 patients underwent 47 surgical procedures for craniopharyngioma.
  • The tumor was totally removed in 36 procedures (76.6%), subtotally in 10 (21.3%), and partially in 1 (2.1%).
  • The rate of tumor recurrence was 24.4%.
  • The recurrence-free survival rate was significantly different between patients in whom complete tumor resection was accomplished and those in whom tumor resection was incomplete.
  • CONCLUSIONS: The pituitary stalk must be preserved with maximal tumor resection whenever possible to increase the chance of intact anterior pituitary function being maintained.
  • [MeSH-major] Craniopharyngioma / surgery. Pituitary Gland. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Postoperative Complications. Vision Disorders / etiology

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  • (PMID = 19361259.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Eskandary H, Sabba M, Khajehpour F, Eskandari M: Incidental findings in brain computed tomography scans of 3000 head trauma patients. Surg Neurol; 2005 Jun;63(6):550-3; discussion 553
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  • [Title] Incidental findings in brain computed tomography scans of 3000 head trauma patients.
  • We studied the frequency of incidental findings on 3000 brain CT scans of trauma patients.
  • METHODS: Three thousands standard brain CT scans of trauma patients were evaluated for some incidental findings.
  • RESULTS: In this study we found 30 incidental abnormalities that include 8 cases of tumor: 3 meningioma, 2 craniopharyngioma, 1 oligodendroglioma, 1 low-grade astrocytoma, and 1 medulloblastoma.
  • Three suspect lipomas were found in midline and near midline of the brain.
  • CONCLUSION: Cisterna magna enlargement was the most common incidental finding and brain tumor and arachnoid cyst were next in frequency.
  • [MeSH-major] Brain / radiography. Brain Diseases / radiography. Brain Neoplasms / radiography. Craniocerebral Trauma / radiography. Tomography, X-Ray Computed / statistics & numerical data
  • [MeSH-minor] Adolescent. Adult. Aged. Arachnoid Cysts / pathology. Arachnoid Cysts / radiography. Calcinosis / pathology. Calcinosis / radiography. Child. Child, Preschool. Comorbidity. Cross-Sectional Studies. Female. Humans. Hydrocephalus / pathology. Hydrocephalus / radiography. Infant. Infant, Newborn. Male. Middle Aged. Prevalence


23. Gonçalves MI, Radzinsky TC, da Silva NS, Chiari BM, Consonni D: Speech-language and hearing complaints of children and adolescents with brain tumors. Pediatr Blood Cancer; 2008 Mar;50(3):706-8
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  • [Title] Speech-language and hearing complaints of children and adolescents with brain tumors.
  • Central nervous system (CNS) tumors generally leave sequelae that may compromise speech, language, swallowing, hearing, and voice functions.
  • This report describes the incidence of speech-language and hearing complaints and disorders in children and adolescents with CNS tumor under treatment at one of the most important Brazilian reference center for pediatric cancer.
  • [MeSH-major] Brain Neoplasms / complications. Hearing Loss / etiology. Language Disorders / etiology. Speech Disorders / etiology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Astrocytoma / complications. Astrocytoma / drug therapy. Child. Child, Preschool. Craniopharyngioma / complications. Craniopharyngioma / drug therapy. Deglutition Disorders / etiology. Ependymoma / complications. Ependymoma / drug therapy. Facial Paralysis / etiology. Female. Humans. Infant. Male. Medulloblastoma / complications. Medulloblastoma / drug therapy

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17534932.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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24. Kiehna EN, Mulhern RK, Li C, Xiong X, Merchant TE: Changes in attentional performance of children and young adults with localized primary brain tumors after conformal radiation therapy. J Clin Oncol; 2006 Nov 20;24(33):5283-90
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  • [Title] Changes in attentional performance of children and young adults with localized primary brain tumors after conformal radiation therapy.
  • PURPOSE: To prospectively assess the impact of conformal radiation therapy (CRT) and demographic and clinical variables on four measures of attention in pediatric and young adult patients with localized primary brain tumors.
  • PATIENTS AND METHODS: We prospectively evaluated 120 patients with primary brain tumors, ages 2 to 24.4 years (median, 9.2 years).
  • After CRT, inattentiveness increased significantly (P = .03), and global attention disorders were associated with craniopharyngioma (P < .0001), supratentorial tumors (P = .008), optic pathway and diencephalic tumors (P = .012), and subtotal resection of the tumor (P = .010).
  • CONCLUSION: Brain tumors and their treatment impair sustained attention and reaction time.
  • Local tumor effects, initial surgical intervention, and focal irradiation of central structures contribute to long-lasting attentional problems in pediatric and young adult patients.
  • [MeSH-major] Attention / radiation effects. Brain Neoplasms / psychology. Brain Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Impulsive Behavior / etiology. Radiotherapy, Conformal / adverse effects
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Male. Prospective Studies

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  • (PMID = 17114662.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA023944; United States / NCI NIH HHS / CA / CA21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Kawamata T, Kubo O, Hori T: Histological findings at the boundary of craniopharyngiomas. Brain Tumor Pathol; 2005;22(2):75-8
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  • [Title] Histological findings at the boundary of craniopharyngiomas.
  • Although a craniopharyngioma is grossly well circumscribed, microscopically the borders are frequently irregular and may be associated with gliosis in the adjacent brain tissue.
  • In the current study, we investigated the histology of the interface between craniopharyngiomas and surrounding normal structures such as the hypothalamus and pituitary gland.
  • Histologically, we classified the findings at the boundary of craniopharyngiomas into three types.
  • In type 1, a relatively thick capsule-like tissue was identified at the boundary between the craniopharyngioma and surrounding normal structure composed of tumor cells and inflammatory changes.
  • In type 2, a craniopharyngioma had a relatively clear cleavage between the surrounding gliosis.
  • In type 3, the boundary had some interdigitation of the tumor in the surrounding gliotic layer adjacent to the craniopharyngioma.
  • In types 1 and 3, surgeons may fail to accomplish complete resection of the tumor.
  • These histological features may result in recurrence of craniopharyngioma even after gross total resection.
  • [MeSH-major] Craniopharyngioma / ultrastructure. Hypothalamus / ultrastructure. Pituitary Gland / ultrastructure. Pituitary Neoplasms / ultrastructure
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Stem / ultrastructure. Child. Child, Preschool. Female. Gliosis / etiology. Gliosis / pathology. Humans. Infant. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Visual Pathways / ultrastructure. Young Adult

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  • (PMID = 18095108.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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26. Schmalisch K, Beschorner R, Psaras T, Honegger J: Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature. Acta Neurochir (Wien); 2010 Feb;152(2):313-9; discussion 319
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  • [Title] Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature.
  • PURPOSE: Seeding of craniopharyngioma has been rarely reported.
  • METHODS: The first patient was a 13-year-old boy who had initially undergone radical excision of a suprasellar and retrosellar craniopharyngioma by a right pterional approach.
  • Postoperative MRI showed no evidence of residual tumor.
  • Two years later, MRI revealed a local recurrence and in addition a separated cystic tumor on the right side adjacent to the middle cerebral artery consistent with seeding along the surgical route.
  • On histopathological examination, both, the local recurrent tumor and the distant deposit turned out to be adamantinomatous craniopharyngiomas.
  • The second patient was a 27-year-old woman who was operated on for the first time via a right pterional and 1 year later for a recurrent craniopharyngioma via a transsphenoidal approach.
  • This deposit in the operative pathway was found to be an adamantinomatous craniopharyngioma, as was the initial tumor.
  • The recent control MRT revealed a right parietal intracranial tumor with peripheral contrast enhancement, which was located distant to the former craniotomy.
  • The tumor was removed and histopathological examination revealed an adamantinomatous craniopharyngioma in accordance with the initial tumor.
  • CONCLUSION: Although craniopharyngiomas exhibit a benign histopathological pattern, cerebrospinal fluid seeding along the surgical route or along the CSF pathways has been observed.
  • Ectopic recurrence of craniopharyngioma suggests that meticulous protection of the whole surgical field and careful handling of the tumor during the operation are required.
  • [MeSH-major] Brain Neoplasms / secondary. Craniopharyngioma / secondary. Neoplasm Metastasis / pathology. Neoplasm Seeding. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Craniotomy. Female. Frontal Bone / pathology. Frontal Bone / surgery. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Parietal Bone / pathology. Parietal Bone / surgery. Reoperation. Treatment Outcome

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  • (PMID = 19859655.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 31
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27. Tena-Suck ML, Salinas-Lara C, Arce-Arellano RI, Rembao-Bojórquez D, Morales-Espinosa D, Sotelo J, Arrieta O: Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas. Clin Neurol Neurosurg; 2006 Oct;108(7):661-9
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  • [Title] Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas.
  • BACKGROUND: Craniopharyngioma is a rare, benign epithelial brain tumor of the suprasellar region with a high rate of recurrence.
  • METHODS: We compared recurrence/regrowth of the tumors with the clinico-pathological characteristics, vascular density, cell proliferation index, and immunohistochemical profile (cytokeratins, epithelial membrane antigen [EMA], carcinoembrionary antigen [CEA], and laminin) of 47 patients with craniopharyngioma followed for more than 5 years.
  • Residual tumor after surgery, whorl-like arrays (p=0.04) and immunoreactivity for p53 (p=0.022) were significantly related to recurrence/regrowth.
  • CONCLUSIONS: Residual tumor after surgery, immunoreactivity to p53 and presence of whorl-like arrays are associated to recurrence/regrowth of craniopharyngioma.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / physiopathology. Craniopharyngioma / diagnosis. Craniopharyngioma / physiopathology. Neoplasm Recurrence, Local / epidemiology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoembryonic Antigen / metabolism. Cell Proliferation. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Keratins / metabolism. Laminin / metabolism. Male. Mucin-1 / metabolism. Neovascularization, Pathologic / diagnosis. Neovascularization, Pathologic / epidemiology. Neovascularization, Pathologic / physiopathology. Predictive Value of Tests. Prognosis. Radiotherapy / statistics & numerical data. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16500745.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Laminin; 0 / Mucin-1; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
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28. Dehdashti AR, Ganna A, Witterick I, Gentili F: Expanded endoscopic endonasal approach for anterior cranial base and suprasellar lesions: indications and limitations. Neurosurgery; 2009 Apr;64(4):677-87; discussion 687-9
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  • METHODS: From June 2005 to June 2007, the expanded endoscopic endonasal approach was used in 22 patients with the following pathologies: 6 craniopharyngiomas; 4 esthesioneuroblastomas; 3 giant pituitary macroadenomas; 2 suprasellar Rathke's pouch cysts; 2 angiofibromas; and 1 each of suprasellar meningioma, germinoma, ethmoidal carcinoma, adenoid cystic carcinoma, and large suprasellar arachnoid cyst.
  • RESULTS: Gross total tumor removal, as assessed by postoperative magnetic resonance imaging, was possible in the majority of patients (73%), with the exception of the craniopharyngioma group, in which only 1 lesion was completely removed.
  • Large lesions, significant lateral extension, encasement of neurovascular structures, and brain invasion in malignant lesions are considered some of the contraindications for this technique.
  • The avoidance of craniotomy and brain retraction and reduced neurovascular manipulation with less morbidity are potential advantages.
  • [MeSH-major] Brain Neoplasms / surgery. Nasal Cavity / surgery. Neuroendoscopy / methods. Neurosurgical Procedures / methods. Sella Turcica / surgery. Skull Base / surgery
  • [MeSH-minor] Adult. Aged. Craniopharyngioma / surgery. Esthesioneuroblastoma, Olfactory / surgery. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neurofibroma / surgery. Retrospective Studies. Young Adult

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  • (PMID = 19349826.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Fatemi N, Dusick JR, de Paiva Neto MA, Malkasian D, Kelly DF: Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas. Neurosurgery; 2009 May;64(5 Suppl 2):269-84; discussion 284-6
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  • [Title] Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas.
  • OBJECTIVE: Endonasal and supraorbital "eyebrow" craniotomies are increasingly being used to remove craniopharyngiomas and tuberculum sellae meningiomas.
  • METHODS: All consecutive patients who had endonasal or supraorbital removal of a craniopharyngioma or tuberculum sellae meningioma were analyzed.
  • RESULTS: Of 43 patients, 22 had a craniopharyngioma (18 endonasal, 4 supraorbital), and 21 had a meningioma (12 endonasal, 7 supraorbital, 2 both routes); 33% had prior surgery.
  • Craniopharyngiomas were primarily retrochiasmal in location in 78% of endonasal cases versus 25% of supraorbital cases (P = 0.08).
  • Of patients having first-time surgery for a craniopharyngioma (n = 14) or meningioma (n = 15), total/near total removal was achieved in 83% and 80% of patients by the endonasal route and in 50% and 80% of patients by the supraorbital route, respectively.
  • CONCLUSION: The endonasal route is preferred for removal of most retrochiasmal craniopharyngiomas, whereas the supraorbital route is recommended for meningiomas larger than 30 to 35 mm or with growth beyond the supraclinoid carotid arteries.
  • For smaller midline tumors, either approach can be used, depending on surgeon experience and tumor anatomy.
  • [MeSH-major] Craniopharyngioma / surgery. Craniotomy / methods. Meningeal Neoplasms / surgery. Meningioma / surgery. Pituitary Neoplasms / surgery. Sella Turcica / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Endoscopy / methods. Female. Frontal Bone / anatomy & histology. Frontal Bone / surgery. Humans. Intraoperative Complications / prevention & control. Male. Middle Aged. Nasal Cavity / anatomy & histology. Nasal Cavity / surgery. Neurosurgical Procedures / instrumentation. Neurosurgical Procedures / methods. Orbit / anatomy & histology. Orbit / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19287324.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Shi XE, Wu B, Zhou ZQ, Fan T, Zhang YL: Microsurgical treatment of craniopharyngiomas: report of 284 patients. Chin Med J (Engl); 2006 Oct 5;119(19):1653-63
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  • [Title] Microsurgical treatment of craniopharyngiomas: report of 284 patients.
  • BACKGROUND: Generally, total surgical removal of craniopharyngioma results in satisfactory outcome with a low recurrence rate, however, the location of the tumor and its adherence to the hypothalamic structures can make the operation difficult.
  • The goal of the present study was to assess the outcome of craniopharyngiomas in 284 patients treated surgically.
  • METHODS: A total of 284 patients (151 men and 133 women) with craniopharyngioma were treated surgically by our neurosurgeons from January 1996 to March 2006.
  • The tumors were classified into the superior (23 patients) and inferior ventricular (261) types according to the location of the tumor relative to the third ventricular floor.
  • For the patients with craniopharyngioma of inferior ventricular type, pterional approach was used in 191 (67.3%) patients, subfrontal approach in 17 (6.0%), and translamina terminalis through frontobasal interhemispheric approach in 53 (18.7%).
  • Of the 284 patients, 204 (71.8%) were followed up for 0.5 to 8 years (mean, 2.1 +/- 1.8), including 162 patients received total tumor removal, and 37 underwent subtotal or partial removal.
  • During the follow-up, 23 (14.1%) patients experienced tumor recurrence 1.0 - 3.5 years (mean, 1.8 +/- 1.6) after total tumor removal, and 24 (64.9%) had recurrent tumor 0.25 - 1.5 years (mean, 0.5 +/- 0.4) after subtotal or partial resection.
  • In addition, preservation of the pituitary stalk is critical when total tumor resection is feasible.
  • [MeSH-major] Craniopharyngioma / surgery. Microsurgery / methods. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged

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  • (PMID = 17042979.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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31. Jane JA Jr, Kiehna E, Payne SC, Early SV, Laws ER Jr: Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas. Neurosurg Focus; 2010 Apr;28(4):E9
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  • [Title] Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas.
  • OBJECT: Although the transsphenoidal approach for subdiaphragmatic craniopharyngiomas has been performed for many years, there are few reports describing the role of the endoscopic transsphenoidal technique for suprasellar craniopharyngiomas.
  • The purpose of this study was to report the outcomes of the endoscopic transsphenoidal approach for adults with craniopharyngiomas in whom the goal was gross-total resection.
  • CONCLUSIONS: The authors have achieved a high rate of radical resection and symptomatic improvement with the endoscopic transsphenoidal technique for both subdiaphragmatic (sellar/suprasellar) and supradiaphragmatic (suprasellar) craniopharyngiomas.
  • Endoscopic assessment of tumor resection may be more sensitive for residual tumor than the first postoperative MR imaging study.
  • [MeSH-major] Craniopharyngioma / surgery. Neuroendoscopy / methods. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Diabetes Insipidus / etiology. Female. Humans. Hypopituitarism / etiology. Magnetic Resonance Imaging. Male. Microsurgery / methods. Middle Aged. Postoperative Complications / etiology. Sella Turcica / pathology. Sella Turcica / surgery. Sphenoid Sinus. Treatment Outcome. Tumor Burden. Vision Disorders / etiology

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  • (PMID = 20367523.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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32. Okuyama T, Fukuyama A, Fukuyama K, Ikeno K, Araki H, Okada K, Sohma N: [Three-dimensional imaging of the optic nerve using magnetic resonance angiography--application to anterior communicating artery aneurysm and craniopharingioma]. No Shinkei Geka; 2005 Apr;33(4):351-5
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  • The optic nerve and brain tumor were traced with paintbrush from one sheet to another of the reformed images after subtraction of the blood vessels around the anterior communicating artery in these reformed images, and then three-dimensional images were constructed.
  • The optic nerve and anterior communicating arterial aneurysm or brain tumor were both observed in the overlapped 3D-SSD (shaded surface display) images.
  • Three-dimensional images of the optic nerve and anterior communicating artery aneurysm or brain tumor were able to be made in all cases.
  • As a preoperative investigation for anterior communicating artery aneurysm or suprasellar brain tumor, we considered that three-dimensional imaging of the optic nerve is useful in the operative approach because the optic nerve acts as a merkmal for the anterior communicating aneurysm or brain tumor.
  • [MeSH-major] Craniopharyngioma / diagnosis. Imaging, Three-Dimensional. Intracranial Aneurysm / diagnosis. Magnetic Resonance Angiography. Optic Nerve / pathology. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Aneurysm, Ruptured / diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 15830541.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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33. Fatemi N, Dusick JR, de Paiva Neto MA, Kelly DF: The endonasal microscopic approach for pituitary adenomas and other parasellar tumors: a 10-year experience. Neurosurgery; 2008 Oct;63(4 Suppl 2):244-56; discussion 256
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  • From July 1998 to January 2008, 812 patients underwent a total of 881 operations for a pituitary adenoma (n = 605), Rathke's cleft cyst (n = 59), craniopharyngioma (n = 26), parasellar meningioma (n = 23), chordoma (n = 18), or other pathological condition (n = 81).
  • [MeSH-minor] Adult. Aged. Chordoma / surgery. Cranial Fossa, Posterior / surgery. Craniopharyngioma / surgery. Databases, Factual. Female. Humans. Male. Medical Illustration. Middle Aged. Optic Chiasm / pathology. Postoperative Complications / etiology. Retrospective Studies. Sphenoid Bone / surgery. Young Adult

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  • (PMID = 18981830.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Van Gompel JJ, Nippoldt TB, Higgins DM, Meyer FB: Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity. Neurosurg Focus; 2010 Apr;28(4):E3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity.
  • OBJECT: Obesity as a consequence of management of pediatric craniopharyngioma is a well-described phenomenon related to the degree of hypothalamic involvement.
  • However, weight change and obesity have not been analyzed in adult patients.
  • Therefore, the purpose of this study was 1) to evaluate the pattern of postoperative weight gain related to preoperative body mass index (BMI), 2) determine if postoperative weight gain is an issue in adult patients, and 3) develop an objective MR imaging grading system to predict risk of postoperative weight gain and obesity in adults treated for craniopharyngioma.
  • METHODS: The authors retrospectively screened 296 patients with known craniopharyngioma for the following inclusion criteria: pathologically confirmed craniopharyngioma, index surgery at the authors' institution, and operative weight and height recorded with at least 3 months of follow-up including body weight measurement.
  • Cases of craniopharyngiomas were compared with age- and sex-matched controls (pituitary adenoma patients) to evaluate the pattern and significance of perioperative weight changes.
  • Comparing craniopharyngioma patients (cases) to age- and sex-matched controls, the preoperative BMIs were similar (p = 0.93) between cases (mean 28.9 [95% CI 30.9-26.9]) and controls (mean 29.3 [95% CI 31.9-26.7]).
  • CONCLUSIONS: Postoperative weight gain in adult patients undergoing surgery for craniopharyngioma is a significant problem and correlates with hypothalamic involvement, as it does in pediatric patients.
  • [MeSH-major] Craniopharyngioma / surgery. Magnetic Resonance Imaging / statistics & numerical data. Obesity / diagnosis. Pituitary Neoplasms / surgery. Postoperative Complications / diagnosis
  • [MeSH-minor] Adolescent. Adult. Age Factors. Body Mass Index. Female. Follow-Up Studies. Humans. Hypophysectomy / methods. Hypothalamus / pathology. Hypothalamus / surgery. Male. Preoperative Care. Retrospective Studies. Risk Factors. Weight Gain

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  • (PMID = 20367360.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024150
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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35. Zhou L, Li Q, Luo L, Xu J, Zhang Y, Chen T, Wei Y, You C: Radiological features of craniopharyngiomas located in the posterior fossa. J Neurol Sci; 2009 Dec 15;287(1-2):119-25
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  • [Title] Radiological features of craniopharyngiomas located in the posterior fossa.
  • BACKGROUND AND PURPOSE: Posterior fossa craniopharyngiomas (PFCP) constitute 1.6-4% of all craniopharyngiomas and have long been neglected.
  • Seven tumors were of retrochiasmatic origin and 5 of 7 were of retrostalk growth pattern with location in the ventral area of brain stem.
  • Total tumor removal was accomplished in 5 cases, subtotal removal and partial removal in 1 case respectively.
  • Tumor with cystic component arises from sellar region and then extends to posterior fossa, which should be strongly suspected as a PFCP.
  • [MeSH-major] Cranial Fossa, Posterior / pathology. Craniopharyngioma / pathology. Infratentorial Neoplasms / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Central Nervous System Cysts / etiology. Central Nervous System Cysts / pathology. Central Nervous System Cysts / radiography. Child. Cohort Studies. Craniotomy / methods. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Pituitary Gland / pathology. Pituitary Gland / radiography. Pituitary Gland / surgery. Sella Turcica / pathology. Sella Turcica / radiography. Sella Turcica / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19758604.001).
  • [ISSN] 1878-5883
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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36. Gupta DK, Ojha BK, Sarkar C, Mahapatra AK, Mehta VS: Recurrence in craniopharyngiomas: analysis of clinical and histological features. J Clin Neurosci; 2006 May;13(4):438-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence in craniopharyngiomas: analysis of clinical and histological features.
  • The aim of this study was to investigate the recurrence patterns and significance of various clinical and histological features as predictors of recurrence in craniopharyngiomas.
  • A series of 234 craniopharyngiomas (156 males, 78 females; age range 1.6-65 years) was reviewed.
  • Peri-operative mortality was 7.4% and tumor recurrence was observed in 26 patients (20.3%).
  • Of the patients with recurrence, one had total tumor excision (recurrence-free survival (RFS) 14 months), four had near-total excision (mean RFS 18.2 months) and 21 had subtotal tumor excision (RFS for symptomatic recurrence 7.1 months).
  • Brain tissue was included in 67 cases and brain invasion was noted in 44 (all were of adamantinous histology).
  • No correlation was noted between histopathological subtyping or brain invasion and recurrence.
  • The significant clinical factors predictive of recurrence included the extent of resection, tumor size greater than 4 cm and cystic tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Craniopharyngioma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16678722.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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37. Lin KC, Cheng TJ, Yung JM, Kuo JR: Malignant astrocytoma following radiation for nasopharyngeal carcinoma: case report and review of the literature. Acta Neurol Taiwan; 2007 Mar;16(1):27-32
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  • Introduction of brain malignancy induction after external beam radiation for craniopharyngioma, pituitary adenoma, or meningioma has been previously reported.
  • The theoretical risk of tumor induction in neural tissues, following radiotherapy by low-dose radiation has been verified, but the association of radiation-induced brain malignancy and NPC is extremely rare.
  • [MeSH-major] Astrocytoma / etiology. Brain Neoplasms / etiology. Nasopharyngeal Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / etiology. Radiotherapy / adverse effects
  • [MeSH-minor] Adult. Female. Humans. Radiotherapy Dosage

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  • (PMID = 17486730.001).
  • [ISSN] 1028-768X
  • [Journal-full-title] Acta neurologica Taiwanica
  • [ISO-abbreviation] Acta Neurol Taiwan
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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38. Marcus KJ, Goumnerova L, Billett AL, Lavally B, Scott RM, Bishop K, Xu R, Young Poussaint T, Kieran M, Kooy H, Pomeroy SL, Tarbell NJ: Stereotactic radiotherapy for localized low-grade gliomas in children: final results of a prospective trial. Int J Radiat Oncol Biol Phys; 2005 Feb 1;61(2):374-9
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  • PURPOSE: To evaluate the efficacy of stereotactic radiotherapy (SRT) for small, localized, pediatric brain tumors and to determine the patterns of failure.
  • Of the 81 patients, 50 had low-grade astrocytoma, 23 had residual or recurrent craniopharyngioma, 4 had posterior fossa ependymoma, and 4 had other histologic types.
  • All patients underwent biopsy for diagnosis, with the exception of patients with neurofibromatosis and radiographic evidence of an optic system tumor.
  • The target volume generally included the preoperative tumor plus a 2-mm margin for the planning target volume.
  • Five patients, all with optic system/hypothalamic primary tumors, developed central nervous system dissemination 1.0-7.4 years after SRT.
  • One patient developed a presumed radiation-induced primitive neuroectodermal tumor 6 years after initial treatment.
  • Six patients died, three of dissemination, two of progression to higher grade tumors, and one of a secondary radiation-induced tumor.
  • All 6 cases of local progression were within the primary tumor bed at the time of progression and had received the full prescription dose.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Confidence Intervals. Disease Progression. Disease-Free Survival. Female. Humans. Male. Neoplasm Recurrence, Local / drug therapy. Prospective Studies. Radiotherapy Dosage

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  • (PMID = 15667955.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Masaya-anon P, Lorpattanakasem J: Intracranial tumors affecting visual system: 5-year review in Prasat Neurological Institute. J Med Assoc Thai; 2008 Apr;91(4):515-9
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  • [Title] Intracranial tumors affecting visual system: 5-year review in Prasat Neurological Institute.
  • OBJECTIVES: To study the types of intracranial tumors with histological confirmation that impair visual system and to determine the neuro-ophthalmic manifestations in patients with intracranial tumors.
  • The three most common types of intracranial tumors were meningioma (45%), pituitary adenoma (32.9%), tumors of neuroepithelial tissues (6.7%) and craniopharyngioma (6.7%).Common neuro-ophthalmological symptoms were visual blur (88.6%) and proptosis (12.1%).
  • CONCLUSION: From the study, meningioma is the most common tumor that impairs the visual pathway structures followed by pituitary adenoma.
  • [MeSH-major] Academies and Institutes. Brain Neoplasms / complications. Optic Disk / pathology. Vision Disorders / etiology. Visual Fields
  • [MeSH-minor] Adult. Aged. Eye Movements. Female. Humans. Male. Middle Aged. Retrospective Studies. Risk Factors. Thailand. Time Factors

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  • (PMID = 18556861.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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40. Hori T, Kawamata T, Amano K, Aihara Y, Ono M, Miki N: Anterior interhemispheric approach for 100 tumors in and around the anterior third ventricle. Neurosurgery; 2010 Mar;66(3 Suppl Operative):65-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: One hundred patients with 46 craniopharyngiomas, 12 hypothalamic gliomas, 12 meningiomas, 6 hypothalamic hamartomas, and 24 other lesions were operated on using an anterior interhemispheric approach with or without opening of the lamina terminalis.
  • This surgical approach involves no frontal sinus opening; a narrow (approximately 15-20 mm in width) access between the bridging veins, which is sufficient to remove the tumor totally; and sparing of the anterior communicating artery.
  • RESULTS: Total removal of the neoplasm was accomplished in 37 of 46 patients with craniopharyngiomas (80.4%), whereas subtotal resection was performed in hypothalamic gliomas.
  • No significant differences in pre- and postoperative hormonal disturbances were observed in 37 craniopharyngiomas and 10 hypothalamic gliomas.
  • CONCLUSION: The minimally invasive anterior interhemispheric approach, with or without opening of the lamina terminalis, is useful for removal of tumors in and around the anterior third ventricle, such as craniopharyngiomas and hypothalamic gliomas.
  • [MeSH-major] Brain Neoplasms / surgery. Hypothalamus / surgery. Neurosurgical Procedures / methods. Third Ventricle / surgery. Ventriculostomy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Cerebrum / anatomy & histology. Cerebrum / surgery. Child. Child, Preschool. Craniopharyngioma / pathology. Craniopharyngioma / surgery. Female. Glioma / pathology. Glioma / surgery. Hamartoma / pathology. Hamartoma / surgery. Humans. Infant. Male. Meningioma / pathology. Meningioma / surgery. Middle Aged. Minimally Invasive Surgical Procedures / instrumentation. Minimally Invasive Surgical Procedures / methods. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Surgical Instruments / standards. Treatment Outcome. Young Adult

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  • (PMID = 20173574.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Bauchet L, Rigau V, Mathieu-Daudé H, Fabbro-Peray P, Palenzuela G, Figarella-Branger D, Moritz J, Puget S, Bauchet F, Pallusseau L, Duffau H, Coubes P, Trétarre B, Labrousse F, Dhellemmes P, Société Française de Neurochirurgie Pédiatrique, Société Française de Neurochirurgie, Société Française de Neuropathologie, Association des Neuro-Oncologues d'Expression Française: Clinical epidemiology for childhood primary central nervous system tumors. J Neurooncol; 2009 Mar;92(1):87-98

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical epidemiology for childhood primary central nervous system tumors.
  • This work was conducted by the French Brain Tumor Data Bank (FBTDB) and aims to prospectively record all primary central nervous system tumors (PCNST), in France, for which histological diagnosis is available.
  • The Tumor Registry from Herault was authorized to compile the data files with personal identifiers.
  • About 1,017 cases (533 boys and 484 girls) of newly diagnosed childhood PCNST have been recorded (gliomas: 52%, all other neuroepithelial tumors: 31%, craniopharyngioma: 5%, germ cell tumors, meningioma and neurinoma: approximately 3% each, all histological subtypes have been detailed).
  • Tumor resections were performed in 83.3%, and biopsies in 16.7%.
  • The distributions by histology, cryopreservation of the samples, age, sex, tumor site and surgery have been detailed.
  • The long term goals of the FBTDB are to create a national registry and a network to perform epidemiological studies, to implement clinical and basic research protocols, and to evaluate and harmonize the healthcare of children and adult patients affected by PCNST.
  • [MeSH-major] Central Nervous System Neoplasms / epidemiology. Registries
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. France / epidemiology. Humans. Infant. Infant, Newborn. Male

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  • (PMID = 19020806.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Investigator] Aghakhani N; Ali Benali M; Alliez B; Amat D; Amlashi A; Arbez-Gindre F; Arbion F; Assaker R; Aubriot Lorton MH; Auque J; Autricque A; Auvigne I; Averous G; Baldet P; Bataille B; Bazin A; Beaurain J; Benezech J; Bergemer Fouquet A; Besson G; Beuvon F; Billotet C; Blond S; Boetto S; Boissonnet H; Bonyhay G; Bouillot P; Bourgeois P; Bouvier C; Brassier G; Broche C; Brunon J; Cabal P; Cahn V; Caire F; Calvet P; Cazals-Hatem D; Chapon F; Chazal J; Civit T; Colnat S; Colombat M; Comoy J; Couvelard A; Czorny A; Dam Hieu P; Daumas-Duport C; Dautheribes M; David P; Debono B; Delage Corre M; Delhaye M; Delisle MB; Delsol G; Derlon JM; Desenclos C; Desplat A; Devaux B; Di Rocco F; Diaz A; Diebold MD; Dorfmuller G; Dran G; Dufour T; Dumas B; Dumollard JM; Durand L; Duthel R; Eimer S; El Fertit H; Emery E; Espagno C; Esposito P; Etchandy MP; Eyremandi RP; Faillot T; Felix S; Fernandez C; Fesselet J; Fontaine D; Fournier D; François P; Froelich S; Fuentes JM; Fuentes S; Gadan R; Gaspard C; Gay G; Gigaud M; Gil Robles S; Godard J; Gontier MF; Goujon JM; Gray F; Grignon Y; Grisoli F; Guarnieri J; Guyotat J; Hallacq P; Hamlat A; Hayek G; Heitzmann A; Hennequin V; Huot JC; Irthum B; Jacquet G; Jan M; Jaubert F; Jouanneau E; Jouvet A; Justrabo E; Kalamarides M; Kehrli P; Kemeny JL; Keravel Y; Kerdraon R; Khalil T; Khouri K; Khouri S; Klein O; Kujas M; Lacroix C; Lagarrigue J; Langlois O; Lapierre F; Laquerriere A; Laurent MC; Le Gall F; Le Guerinel C; Le Houcq M; Lechapt E; Legars D; Lemaire JJ; Lena G; Lepeintre JF; Leriche B; Lescure JP; Levillain P; Liguoro D; Lioret E; Listrat A; Loiseau H; Lonjon M; Lopes M; Lot G; Louis E; Maheut-Lourmière J; Maillard A; Maitre F; Maitrot D; Majek-Zakine E; Mandonnet E; Manzo N; Marchal JC; Marie B; Maurage CA; Menei P; Mercier P; Mergey E; Metellus P; Michalak S; Michiels JF; Milinkevitch S; Mineo JF; Miquel C; Mireau E; Mohr M; Mokhtari K; Morandi X; Morar S; Moreau JJ; Moreno S; Mourier KL; Mottolese C; Nataf F; Neuville A; Nogues L; Noudel R; Nuti C; Page P; Paquis P; Parent M; Parker F; Pasqualini F; Patey M; Pelissou-Guyotat I; Peoc'h M; Peragut JC; Peruzzi P; Pierre-Kahn A; Pinelli C; Polivka M; Pommepuy I; Ponnelle T; Porhiel V; Proust F; Quintin-Roue I; Ragragui O; Rasendrarijao D; Raynaud P; Redondo A; Renjard L; Reyns N; Richard S; Richaud J; Riem T; Riffaud L; Ringenbach F; Robert G; Roche PH; Rodriguez MA; Roujeau T; Rousseaux P; Rousselet MC; Roux FE; Roux FX; Ruchoux MM; Sabatier J; Sabatier P; Saïkali S; Saint Andre JP; Saint Pierre G; Saint-Rose C; San Galli F; Sautreaux JL; Sawan B; Scavarda D; Segnarbieux F; Seigneuret E; Sindou M; Sorbara R; Sorin A; Stilhart B; Straub P; Taha S; Ternier JP; Tortel MC; Toussaint P; Touzet G; Tremoulet M; Trouillas J; Tubiana A; Uro-Coste E; Vandenbos F; Varlet P; Velut S; Vidal J; Viennet G; Vignaud JM; Vignes JR; Vinchon M; Vital A; Wager M; Weinbreck N; Zerah M
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42. Lan Q, Dong J, Huang Q: Minimally invasive keyhole approaches for removal of tumors of the third ventricle. Chin Med J (Engl); 2006 Sep 5;119(17):1444-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 34 removed tumors in or extended into the third ventricle included 11 craniopharyngiomas, 10 pituitary adenomas, 2 pinealomas, 1 cholesteatoma, 3 germinomas, and 7 gliomas.
  • RESULTS: Total tumor resection was done in 27 (79.4%) of the patients, and subtotal resection in 7 patients (20.6%).
  • Residual tumor was due to tight adherence of germinoma to the vein of Galen (1 patient), craniopharyngioma to the pituitary stalk (3), supratentorial extension of pineal region gliomas (1), suprasellar extension of gliomas (1) and giant pituitary adenoma (1).
  • Complications such as brain contusion, postoperative hemorrhage and infection were not associated with keyhole approaches.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures

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  • (PMID = 16989745.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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43. Berlis A, Vesper J, Ostertag C: Stent placement for intracranial cysts by combined stereotactic/endoscopic surgery. Neurosurgery; 2006 Oct;59(4 Suppl 2):ONS474-9; discussion ONS479-80
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  • The authors present a new treatment method with internal drainage of cysts into the ventricular system using a balloon-mounted vascular stent.
  • METHODS: Six patients with cysts of low-grade gliomas, one with monocystic craniopharyngioma, and one with suprasellar arachnoid cyst were treated between September 2003 and May 2005.
  • The first patient showed recurrence of the tumor cyst 3 months after initial treatment with a Herkulink stent (5 x 18 mm), followed by retreatment with an Omnilink stent (6 x 28 mm; Guidant Corp., Santa Clara, CA).
  • [MeSH-major] Brain Diseases / surgery. Cysts / surgery. Endoscopy / methods. Neurosurgical Procedures / methods. Prosthesis Implantation / methods. Stents. Stereotaxic Techniques
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17041520.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Hölsken A, Kreutzer J, Hofmann BM, Hans V, Oppel F, Buchfelder M, Fahlbusch R, Blümcke I, Buslei R: Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas. Brain Pathol; 2009 Jul;19(3):357-64

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas.
  • Activating beta-catenin (CTNNB1) mutations can be identified in the majority of adamantinomatous craniopharyngiomas (adaCP), suggesting an aberrant Wnt signaling pathway in this histopathologically peculiar tumor entity.
  • We performed a laser-microdissection-based study comparing beta-catenin accumulating vs. non-accumulating tumor cells.
  • Mutational analysis and gene expression profiling using real-time polymerase chain reaction were conducted in adamantinomatous and papillary tumor specimens.
  • Target gene activation, that is, over-expression of Axin2 could be detected in adaCP, especially in tumor cells with nuclear beta-catenin accumulation.
  • Interestingly, accumulating and non-accumulating tumor cell populations carried CTNNB1 mutations within exon 3.
  • [MeSH-major] Craniopharyngioma / genetics. Signal Transduction / physiology. Transcriptional Activation. Wnt Proteins / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Axin Protein. Bone Morphogenetic Protein 4 / genetics. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Cytoskeletal Proteins / genetics. DNA Mutational Analysis. Female. Gene Expression. Humans. Immunohistochemistry. Male. Microdissection. Pituitary Neoplasms / genetics. Pituitary Neoplasms / metabolism. Pituitary Neoplasms / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18540944.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / AXIN2 protein, human; 0 / Axin Protein; 0 / Bone Morphogenetic Protein 4; 0 / Cytoskeletal Proteins; 0 / Wnt Proteins; 0 / beta Catenin
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45. Husain M, Jha DK, Rastogi M: Angiographic catheter: unique tool for neuroendoscopic surgery. Surg Neurol; 2005 Dec;64(6):546-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULT: Total excision, near total removal, and biopsy of the lesions could be achieved in 14, 19, and 38 patients, respectively; however, in 2 patients of thalamic tumor, the biopsied tissue was negative for tumor.
  • Tumor consistency was the deciding factor for their removal by angiographic catheters; soft lesions were sucked easily, whereas only biopsy could be done in firm and nonsuckable lesions.
  • Major bleeding in a case of craniopharyngioma was the complication managed by irrigation followed by external ventricular drain.
  • [MeSH-major] Angiography / instrumentation. Brain Diseases / surgery. Neuroendoscopy. Neurosurgical Procedures / instrumentation
  • [MeSH-minor] Adolescent. Adult. Biopsy / methods. Catheterization. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16293482.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. de Divitiis E, Cavallo LM, Cappabianca P, Esposito F: Extended endoscopic endonasal transsphenoidal approach for the removal of suprasellar tumors: Part 2. Neurosurgery; 2007 Jan;60(1):46-58; discussion 58-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The series consisted of seven pituitary adenomas, seven craniopharyngiomas, three suprasellar Rathke's cleft cysts, two tuberculum sellae meningiomas, and one pilocytic astrocytoma of the chiasm.
  • RESULTS: Tumor removal, as assessed by postoperative magnetic resonance imaging, revealed complete removal of the lesion in four out of seven pituitary adenomas, five out of seven craniopharyngiomas, three out of three Rathke's cleft cysts, and two out of two tuberculum sellae meningiomas.
  • One patient (5%) with craniopharyngioma had a postoperative cerebrospinal fluid leak that required reoperation.
  • [MeSH-major] Brain Neoplasms / surgery. Nasal Cavity / surgery. Neuroendoscopy / methods. Sphenoid Sinus / surgery
  • [MeSH-minor] Adult. Aged. Central Nervous System Neoplasms / diagnosis. Central Nervous System Neoplasms / radiography. Central Nervous System Neoplasms / surgery. Female. Humans. Male. Middle Aged. Sphenoid Bone / radiography. Sphenoid Bone / surgery

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  • (PMID = 17228252.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Binder G, Weber S, Ehrismann M, Zaiser N, Meisner C, Ranke MB, Maier L, Wudy SA, Hartmann MF, Heinrich U, Bettendorf M, Doerr HG, Pfaeffle RW, Keller E, South German Working Group for Pediatric Endocrinology: Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. J Clin Endocrinol Metab; 2009 Apr;94(4):1182-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial.
  • CONTEXT AND OBJECTIVE: The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown.
  • Exclusion criteria were cerebral radiation with more than 30 Gy, tumor remission less than 1 yr, amaurosis, hypothalamic obesity, psychiatric disorders, and unstable hormone medication.
  • INTERVENTION: Patients were randomized to placebo (n = 12) or 25 mg HPLC-purified DHEA/d (n = 11) orally for 12 months after stratification into a nontumor (n = 7) and a tumor group (n = 16).
  • RESULTS: In the placebo group, four patients dropped out because of recurrence of craniopharyngioma, manifestation of type 1 diabetes, and change of residence (n = 2); in the DHEA group, one patient dropped out because of recurrent anxiety attacks.
  • CONCLUSIONS: In adolescent girls with central adrenal insufficiency, daily replacement with 25 mg DHEA orally is beneficial: atrichia pubis vanishes, and psychological well-being improves significantly.
  • [MeSH-minor] Adolescent. Adult. Blood Pressure / drug effects. Blood Pressure / physiology. Brain Neoplasms / epidemiology. Double-Blind Method. Female. Humans. Hydrocortisone / therapeutic use. Obesity / epidemiology. Young Adult

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  • (PMID = 19126625.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 459AG36T1B / Dehydroepiandrosterone; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
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48. Ceylan S, Koc K, Anik I: Extended endoscopic approaches for midline skull-base lesions. Neurosurg Rev; 2009 Jul;32(3):309-19; discussion 318-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extended endoscopic transsphenoidal approach was performed for three patients with pituitary adenoma, two patients with craniopharyngioma, one patient with metastatic lesion, one patient with anaplastic germinoma, two patients with chordoma, one patient with chondrosarcoma, one plasmocytoma, and two patients with tuberculum sella meningioma.
  • Total removal of the tumor was achieved in nine patients and subtotal removal was achieved in four patients.
  • Endoscopic approach permits reaching the lesion without brain retraction and with minimal neurovascular manipulation.
  • [MeSH-minor] Adolescent. Adult. Aged. Chondrosarcoma / pathology. Chondrosarcoma / surgery. Chordoma / pathology. Chordoma / surgery. Female. Germinoma / pathology. Germinoma / surgery. Humans. Magnetic Resonance Imaging. Male. Meningioma / pathology. Meningioma / surgery. Middle Aged. Pituitary Neoplasms / surgery. Plasmacytoma / pathology. Plasmacytoma / surgery. Postoperative Complications / epidemiology. Retrospective Studies. Sella Turcica / pathology. Sella Turcica / surgery. Sphenoid Bone / surgery. Treatment Outcome

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  • (PMID = 19408020.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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49. Dusick JR, Esposito F, Kelly DF, Cohan P, DeSalles A, Becker DP, Martin NA: The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors. J Neurosurg; 2005 May;102(5):832-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Twenty-six procedures for tumor removal were performed in 24 patients (ages 9-79 years), including two repeated operations for residual tumor.
  • Gross-total removal could be accomplished in only 46% of patients, with near-gross-total removal or better in 74% of 23 patients (five of eight with craniopharyngiomas, six of seven with meningiomas, five of six with Rathke cleft cysts, and one of two with a dermoid or epidermoid cyst); a patient with a lymphoma only underwent biopsy.
  • Of 13 patients with tumor-related visual loss, 85% improved postoperatively.
  • [MeSH-major] Brain Neoplasms / surgery. Minimally Invasive Surgical Procedures / methods. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Diseases / surgery. Central Nervous System Cysts / surgery. Child. Craniopharyngioma / surgery. Epidermal Cyst / surgery. Humans. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Pituitary Neoplasms / surgery. Postoperative Complications. Sphenoid Bone. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2005 May;102(5):825-7; discussion 827-8 [15926704.001]
  • (PMID = 15926706.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Kassam AB, Prevedello DM, Thomas A, Gardner P, Mintz A, Snyderman C, Carrau R: Endoscopic endonasal pituitary transposition for a transdorsum sellae approach to the interpeduncular cistern. Neurosurgery; 2008 Mar;62(3 Suppl 1):57-72; discussion 72-4
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pathology consisted of four craniopharyngiomas, four chordomas, and two petroclival meningiomas.
  • RESULTS: Five patients (50%) underwent total resection of the tumor, three patients (30%) underwent near total resection ( > 95% removal), and two patients (20%) had partial resection of petroclival meningiomas with the goal of optic apparatus decompression.
  • The remaining patient with a hypothalamic craniopharyngioma underwent complete resection with obligatory panhypopituitarism and diabetes insipidus.
  • [MeSH-major] Brain Neoplasms / surgery. Nasal Septum / surgery. Neuroendoscopy / methods. Pituitary Gland / surgery. Sella Turcica / surgery. Tegmentum Mesencephali / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 18424968.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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