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1. Campos WK, Linhares MN: Sporadic intramedullary spinal cord hemangioblastoma in a newborn. Pediatr Neurosurg; 2010;46(5):385-9
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  • Spinal cord HB are usually diagnosed in adult patients and their incidence in early infancy is an extreme rarity.
  • MRI of the spine revealed an intramedullary tumor extending from level T6 to T12.
  • RESULTS: The tumor was excised completely, using standard microsurgical techniques via a posterior approach.
  • CONCLUSION: A review of the literature revealed that this neoplasm is composed of 3 major cell types: endothelial cells, pericytes and stromal cells.
  • Complete microsurgical removal is the treatment of choice for spinal cord HB because the tumor is benign.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21389752.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
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2. Medhkour A, Chan M: Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: a case report and review of the literature. Surg Neurol; 2005 Jun;63(6):576-82; discussion 582-3
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  • [Title] Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: a case report and review of the literature.
  • Proper diagnosis via histopathologic and immunochemical staining with close clinical and radiological follow-up is important for the management of this very aggressive tumor.
  • CASE DESCRIPTION: The authors report the clinical features, histopathologic and immunochemical staining characteristics, as well as the radiographic evidence of a case of primary GBM of the conus medullaris with metastases to the whole spinal cord and brain in a 20-year-old man who presented with low back pain and bilateral lower extremity weakness and numbness.
  • Serial magnetic resonance scans, performed after the initial surgery, demonstrated enlargement of the primary GBM in the conus medullaris with metastases to the thoracic and cervical spinal cord as well as to the brain.
  • [MeSH-major] Brain Stem Neoplasms / secondary. Glioblastoma / secondary. Spinal Cord Compression / pathology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Brain Stem / pathology. Brain Stem / physiopathology. Cranial Nerve Diseases / etiology. Cranial Nerve Diseases / pathology. Cranial Nerve Diseases / physiopathology. Disease Progression. Fatal Outcome. Glial Fibrillary Acidic Protein / metabolism. Humans. Low Back Pain / etiology. Low Back Pain / pathology. Low Back Pain / physiopathology. Magnetic Resonance Imaging. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / physiopathology. Paresis / etiology. Paresis / pathology. Paresis / physiopathology. Rare Diseases. Respiratory Insufficiency / etiology. Respiratory Insufficiency / pathology. Respiratory Insufficiency / physiopathology. Spinal Cord / pathology. Spinal Cord / physiopathology

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  • (PMID = 15936395.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
  • [Number-of-references] 13
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3. Kadota RP, Mahoney DH, Doyle J, Duerst R, Friedman H, Holmes E, Kun L, Zhou T, Pollack IF: Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinoma. Pediatr Blood Cancer; 2008 Nov;51(5):675-8
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  • [Title] Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinoma.
  • PURPOSE: To determine the response, toxicity, and survival for children with progressive or recurrent medulloblastoma and germinoma using a single myeloablative course of chemotherapy supported by autologous hematopoietic stem cells.
  • CONCLUSION: Myeloablative chemotherapy consisting of cyclophosphamide and melphalan was tolerable in the relapsed brain tumor setting with 19/29 cases achieving CR or CCR status and 9/29 becoming long-term survivors.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18623206.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA098543-06; United States / NCI NIH HHS / CA / CA98543; United States / NCI NIH HHS / CA / U10 CA098413-06; United States / NCI NIH HHS / CA / U10 CA098413; United States / NCI NIH HHS / CA / U10 CA098543; None / None / / U10 CA098413-06; None / None / / U10 CA098543-06
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 8N3DW7272P / Cyclophosphamide; Q41OR9510P / Melphalan
  • [Other-IDs] NLM/ NIHMS123029; NLM/ PMC2900925
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4. Mimeault M, Hauke R, Mehta PP, Batra SK: Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. J Cell Mol Med; 2007 Sep-Oct;11(5):981-1011
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  • [Title] Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers.
  • Overcoming intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic cancers.
  • This review summarizes recent advances in our understanding of the cellular origin and molecular mechanisms at the basis of cancer initiation and progression as well as the heterogeneity of cancers arising from the malignant transformation of adult stem/progenitor cells.
  • We describe the critical functions provided by several growth factor cascades, including epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor (SCF) receptor (KIT), hedgehog and Wnt/beta-catenin signalling pathways that are frequently activated in cancer progenitor cells and are involved in their sustained growth, survival, invasion and drug resistance.
  • Of therapeutic interest, we also discuss recent progress in the development of new drug combinations to treat the highly aggressive and metastatic cancers including refractory/relapsed leukaemias, melanoma and head and neck, brain, lung, breast, ovary, prostate, pancreas and gastrointestinal cancers which remain incurable in the clinics.

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  • (PMID = 17979879.001).
  • [ISSN] 1582-1838
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA111294; United States / NCI NIH HHS / CA / CA72712; United States / NCI NIH HHS / CA / R01 CA078590; United States / NCI NIH HHS / CA / CA78590; United States / NCI NIH HHS / CA / P50 CA072712; United States / NCI NIH HHS / CA / CA111294
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Number-of-references] 242
  • [Other-IDs] NLM/ PMC4401269
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5. Reynolds BA, Vescovi AL: Brain cancer stem cells: Think twice before going flat. Cell Stem Cell; 2009 Nov 6;5(5):466-7; author reply 468-9
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  • [Title] Brain cancer stem cells: Think twice before going flat.
  • [MeSH-major] Brain Neoplasms / pathology. Cell Culture Techniques. Glioblastoma / pathology. Glioma / pathology. Neoplastic Stem Cells / pathology
  • [MeSH-minor] Adult. Animals. Apoptosis. Cell Adhesion. Cell Differentiation. Cell Line, Tumor. Humans. Mice. Neoplasm Transplantation. Reproducibility of Results


6. Patru C, Romao L, Varlet P, Coulombel L, Raponi E, Cadusseau J, Renault-Mihara F, Thirant C, Leonard N, Berhneim A, Mihalescu-Maingot M, Haiech J, Bièche I, Moura-Neto V, Daumas-Duport C, Junier MP, Chneiweiss H: CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors. BMC Cancer; 2010;10:66
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  • [Title] CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors.
  • BACKGROUND: Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies.
  • METHODS: We screened for TICs in 47 human adult brain malignant tumors.
  • Cells forming floating spheres in culture, and endowed with all of the features expected from tumor cells with stem-like properties were obtained from glioblastomas, medulloblastoma but not oligodendrogliomas.
  • Xenografts of fewer than 500 cells in Nude mouse brains induced a progressively growing tumor.
  • [MeSH-major] Antigens, CD / biosynthesis. Antigens, CD15 / biosynthesis. Antigens, CD34 / biosynthesis. Brain Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Glioma / metabolism. Glycoproteins / biosynthesis. Neoplastic Stem Cells / cytology. Neurons / pathology
  • [MeSH-minor] Animals. Cell Line, Tumor. Humans. Mice. Mice, Nude. Neoplasm Transplantation. Peptides. Proteomics / methods

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  • (PMID = 20181261.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Antigens, CD15; 0 / Antigens, CD34; 0 / Glycoproteins; 0 / Peptides
  • [Other-IDs] NLM/ PMC2841664
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7. Doyle DM, Einhorn LH: Delayed effects of whole brain radiotherapy in germ cell tumor patients with central nervous system metastases. Int J Radiat Oncol Biol Phys; 2008 Apr 1;70(5):1361-4
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  • [Title] Delayed effects of whole brain radiotherapy in germ cell tumor patients with central nervous system metastases.
  • CNS metastases have been managed with whole brain radiotherapy (WBRT) and concomitant cisplatin-based combination chemotherapy.
  • CONCLUSION: Whole brain radiotherapy is not innocuous in young patients with germ cell tumors and can cause late CNS toxicity.
  • [MeSH-major] Brain / radiation effects. Brain Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Neoplasms, Germ Cell and Embryonal / radiotherapy. Radiation Injuries / complications. Testicular Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / blood. Choriocarcinoma / drug therapy. Choriocarcinoma / radiotherapy. Choriocarcinoma / secondary. Chorionic Gonadotropin / blood. Cisplatin / administration & dosage. Combined Modality Therapy / adverse effects. Combined Modality Therapy / methods. Fatal Outcome. Humans. Leukoencephalopathy, Progressive Multifocal / etiology. Lung Neoplasms / secondary. Male. Neoplasm Proteins / blood. Radiotherapy Dosage. Salvage Therapy / methods. Stem Cell Transplantation. Time Factors

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  • [CommentIn] Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1300-2 [18374219.001]
  • (PMID = 18374223.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / Neoplasm Proteins; Q20Q21Q62J / Cisplatin
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8. Ehtesham M, Stevenson CB, Thompson RC: Stem cell therapies for malignant glioma. Neurosurg Focus; 2005 Sep 15;19(3):E5
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  • [Title] Stem cell therapies for malignant glioma.
  • The prognosis for patients with malignant glioma, which is the most common primary intracranial neoplasm, remains dismal despite significant progress in neurooncological therapies and technology.
  • Malignant glial cells often disseminate throughout the brain, making it exceedingly difficult to target and treat all intracranial neoplastic foci, with the result that tumor recurrence is inevitable despite aggressive surgery and adjuvant radiotherapy and/or chemotherapy.
  • The use of neural stem cells (NSCs) as delivery vehicles for tumor-toxic molecules represents the first experimental strategy aimed specifically at targeting disseminated tumor pockets.
  • Investigators have demonstrated that NSCs possess robust tropism for infiltrating tumor cells, and that they can be used to deliver therapeutic agents directly to tumor satellites, with significant therapeutic benefit.
  • With the aim of developing these findings into a clinically viable technology that would not be hindered by ethical and tissue rejection-related concerns, the use of adult tissue-derived stem cells has recently been explored.
  • These technologies represent important progress in the development of a treatment strategy that can specifically target disseminated neoplastic pockets within the brain.
  • Key among these are an inadequate understanding of the specific tropic mechanisms that govern NSC migration toward invasive tumor, and the need to refine the processes used to generate tumor-tropic stem cells from adult tissues so that this can be accomplished in a clinically practicable fashion.
  • Despite these limitations, the use of stem cell therapies for brain tumors holds significant promise and may emerge as an important therapeutic modality for patients with malignant glioma.
  • [MeSH-major] Brain Neoplasms / therapy. Glioma / therapy. Stem Cell Transplantation / methods. Stem Cells / physiology

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  • (PMID = 16190604.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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9. Gokce M: Analysis of isolated cranial nerve manifestations in patients with cancer. J Clin Neurosci; 2005 Nov;12(8):882-5
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  • They included meningeal carcinomatosis (10/16), brain stem metastases (3/16), primary brain astrocytomas (1/16), and metastases out of the central nervous system (2/16).
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / secondary. Middle Aged. Neoplasm Metastasis / pathology

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  • (PMID = 16326269.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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10. Mori K, Iwata J, Miyazaki M, Osada H, Tange Y, Yamamoto T, Aiko Y, Tamura M, Shiroishi T: Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cells. Neurol Med Chir (Tokyo); 2010;50(7):545-53
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  • [Title] Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cells.
  • Transduction of the suicide gene of Herpes simplex virus thymidine kinase (Hsv-tk) into glioma cells or neural stem cells combined with pro-drug ganciclovir (GCV) treatment has been effective to treat experimental glioma in the rat through the bystander effect.
  • Bone marrow stromal cells (MSCs) in the adult bone marrow have tropism for brain tumors and act as tumor stromal cells.
  • Whether adult MSCs expressing Hsv-tk can also act as effector cells of the bystander killing effect on murine glioma cells was investigated.
  • The animals co-inoculated with 9L glioma cells and MSCs/tk(+) showed significant retardation of tumor growth and prolongation of survival time compared with the animals with 9L glioma cells and MSCs/tk(-).
  • Quantitative findings were established of the novel effects of adult MSCs/tk(+) as effector cells of the bystander killing effect on glioma cells.
  • [MeSH-major] Antiviral Agents / pharmacology. Bone Marrow Cells. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Bystander Effect / genetics. Cell Survival / genetics. Ganciclovir / pharmacology. Genes, Transgenic, Suicide / genetics. Genetic Therapy / methods. Glioma / genetics. Glioma / pathology. Simplexvirus / enzymology. Simplexvirus / genetics. Stromal Cells. Thymidine Kinase / genetics
  • [MeSH-minor] Animals. Cell Division / drug effects. Cell Division / genetics. Cell Line, Tumor. Humans. In Vitro Techniques. Lac Operon / genetics. Male. Mice. Neoplasm Transplantation. Rats. Rats, Inbred F344

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  • (PMID = 20671379.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antiviral Agents; EC 2.7.1.21 / Thymidine Kinase; P9G3CKZ4P5 / Ganciclovir
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11. Curtis KM, Gomez LA, Rios C, Garbayo E, Raval AP, Perez-Pinzon MA, Schiller PC: EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells. BMC Mol Biol; 2010 Aug 17;11:61
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  • [Title] EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells.
  • CONCLUSIONS: In order to make comparisons between heterogeneous MSC populations, as well as adult stem cell like MSC which are used in different laboratories throughout the world, it is important to have a standardized, reproducible set of housekeeping genes for RT-qPCR analysis.

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  • (PMID = 20716364.001).
  • [ISSN] 1471-2199
  • [Journal-full-title] BMC molecular biology
  • [ISO-abbreviation] BMC Mol. Biol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS045676; United States / NINDS NIH HHS / NS / #NS34773; United States / NINDS NIH HHS / NS / NS045676-06; United States / NCRR NIH HHS / RR / #P40RR017447; United States / NINDS NIH HHS / NS / R01 NS045676-06; United States / NINDS NIH HHS / NS / R01 NS034773
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Molecular Chaperones; 0 / Neoplasm Proteins; 0 / Peptide Elongation Factor 1; 0 / RPL13 protein, human; 0 / Ribosomal Proteins; 0 / Ywhaz protein, rat; 103107-01-3 / Fibroblast Growth Factor 2; 62229-50-9 / Epidermal Growth Factor; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases; S88TT14065 / Oxygen
  • [Other-IDs] NLM/ PMC2931506
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12. Tabatabai G, Frank B, Möhle R, Weller M, Wick W: Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12. Brain; 2006 Sep;129(Pt 9):2426-35
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  • Previously we defined a pathway of transforming growth factor beta (TGF-beta) and stromal cell-derived factor-1/CXC chemokine ligand 12 (SDF-1alpha/CXCL12) dependent migration of adult haematopoietic stem and progenitor cells (HPC) towards glioma cells in vitro and their homing to experimental gliomas in vivo.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Cell Hypoxia / physiology. Chemokines, CXC / physiology. Glioma / radiotherapy. Hematopoietic Stem Cells / physiology. Hypoxia-Inducible Factor 1, alpha Subunit / physiology. Transforming Growth Factor beta / physiology
  • [MeSH-minor] Animals. Antineoplastic Agents, Alkylating / pharmacology. Brain / pathology. Brain / radiation effects. Cell Line, Tumor. Cell Movement / radiation effects. Chemokine CXCL12. Dacarbazine / analogs & derivatives. Dacarbazine / pharmacology. Gamma Rays. Humans. Immunohistochemistry / methods. Mice. Mice, Nude. Neoplasm Proteins / physiology. Promoter Regions, Genetic / genetics. Signal Transduction / genetics. Transcription, Genetic

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  • (PMID = 16835250.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / CXCL12 protein, human; 0 / Chemokine CXCL12; 0 / Chemokines, CXC; 0 / Cxcl12 protein, mouse; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Neoplasm Proteins; 0 / Transforming Growth Factor beta; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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13. Nakamura Y, Kanemura Y, Yamada T, Sugita Y, Higaki K, Yamamoto M, Takahashi M, Yamasaki M: D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells. Mod Pathol; 2006 Jul;19(7):974-85
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  • [Title] D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells.
  • Some brain tumors such as anaplastic ependymoma, some medulloblastomas, glioblastoma, pineal germinoma, craniopharyngioma, choroid plexus papilloma, choroid plexus carcinoma, and meningioma showed positive immunoreactivity with D2-40.
  • Therefore, D2-40 antibody is considered a useful marker for research on developing brain and diagnosis of brain tumors, differentiation between choroid plexus carcinoma and metastatic carcinoma.
  • In addition, on cultured human neural cells, D2-40 immunoreactivity was found in nestin-positive neural stem/progenitor cells and neuronal lineage cells.
  • As D2-40 antibody recognizes cell surface antigen M2A, it might be a candidate cell surface marker for isolation of human neural stem cells/neuronal lineage cells in the fluorescence-activated cell sorting technique.
  • [MeSH-major] Antibodies, Monoclonal. Antigens, Neoplasm / analysis. Brain Neoplasms / immunology. Cerebellum / immunology. Telencephalon / immunology
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Cell Differentiation. Cells, Cultured. Child, Preschool. Fetus / immunology. Gestational Age. Humans. Immunohistochemistry. Infant. Middle Aged. Neurons / cytology. Neurons / immunology. Prosencephalon / cytology. Stem Cells / cytology. Stem Cells / immunology

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  • (PMID = 16648867.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, Neoplasm; 0 / monoclonal antibody D2-40; 0 / oncofetal antigens
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14. Shiras A, Chettiar ST, Shepal V, Rajendran G, Prasad GR, Shastry P: Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells; 2007 Jun;25(6):1478-89
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  • [Title] Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma.
  • The presence of a CD133+/nestin+ population in brain tumors suggests that a normal neural stem cell may be the cell of origin for gliomas.
  • We have identified human CD133-positive NSCs from adult glioma tissue and established them as long-term in vitro cultures human neuroglial culture (HNGC)-1.
  • Replicative senescence in HNGC-1 led to a high level of genomic instability and emergence of a spontaneously immortalized clone that developed into cell line HNGC-2 with features of cancer stem cells (CSCs), which include the ability for self-renewal and the capacity to form CD133-positive neurospheres and develop intracranial tumors.
  • The activated forms of Notch and Hes isoforms were expressed in both non-neoplastic neural stem cells and brain tumor stem cells derived from it.
  • Importantly, a significant overexpression of these molecules was found in the brain tumor stem cells.
  • These findings suggest that this model comprised of HNGC-1 and HNGC-2 cells would be a useful system for studying pathways involved in self-renewal of stem cells and their transformation to cancer stem cells.
  • [MeSH-major] Adult Stem Cells / pathology. Brain Neoplasms / pathology. Cell Transformation, Neoplastic / genetics. Genomic Instability / physiology. Glioblastoma / pathology. Models, Biological. Neoplastic Stem Cells / pathology
  • [MeSH-minor] Animals. Cell Aging / genetics. Cell Proliferation. Humans. Mice. Mice, Nude. Neoplasm Invasiveness / genetics. Neoplasm Invasiveness / pathology. Telomerase / metabolism. Tumor Cells, Cultured

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  • (PMID = 17332509.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.7.49 / Telomerase
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15. Dai KY, Chan SH, Chang AY: Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla. J Biomed Sci; 2010;17:72
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  • [Title] Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla.
  • BACKGROUND: Despite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death.
  • A suitable neural substrate for mechanistic delineation on brain stem death resides in the rostral ventrolateral medulla (RVLM) because it is the origin of a life-and-death signal that sequentially increases (pro-life) and decreases (pro-death) to reflect the advancing central cardiovascular regulatory dysfunction during the progression towards brain stem death in critically ill patients.
  • The present study evaluated the hypothesis that heme oxygnase-1 (HO-1) may play a pro-life role as an interposing signal between hypoxia-inducible factor-1 (HIF-1) and nitric oxide synthase I (NOS I)/protein kinase G (PKG) cascade in RVLM, which sustains central cardiovascular regulatory functions during brain stem death.
  • METHODS: We performed cardiovascular, pharmacological, biochemical and confocal microscopy experiments in conjunction with an experimental model of brain stem death that employed microinjection of the organophosphate insecticide mevinphos (Mev; 10 nmol) bilaterally into RVLM of adult male Sprague-Dawley rats.
  • RESULTS: Western blot analysis coupled with laser scanning confocal microscopy revealed that augmented HO-1 expression that was confined to the cytoplasm of RVLM neurons occurred preferentially during the pro-life phase of experimental brain stem death and was antagonized by immunoneutralization of HIF-1α or HIF-1β in RVLM.
  • CONCLUSIONS: We conclude that transcriptional upregulation of HO-1 on activation by HIF-1 in RVLM plays a preferential pro-life role by sustaining central cardiovascular regulatory functions during brain stem death via upregulation of NOS I/PKG signaling pathway.
  • [MeSH-major] Brain Death / physiopathology. Heme Oxygenase-1 / metabolism. Insecticides / toxicity. Medulla Oblongata / drug effects. Mevinphos / toxicity. Signal Transduction / physiology
  • [MeSH-minor] Analysis of Variance. Animals. Blotting, Western. Cyclic GMP-Dependent Protein Kinases / metabolism. Fluorescent Antibody Technique. Gene Knockdown Techniques. Male. Microscopy, Confocal. Neoplasm Proteins / metabolism. Nitric Oxide Synthase Type I / metabolism. Oligonucleotides / genetics. Rats. Rats, Sprague-Dawley

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  • (PMID = 20819234.001).
  • [ISSN] 1423-0127
  • [Journal-full-title] Journal of biomedical science
  • [ISO-abbreviation] J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HIG1 protein, human; 0 / Insecticides; 0 / Neoplasm Proteins; 0 / Oligonucleotides; 7786-34-7 / Mevinphos; EC 1.14.13.39 / Nitric Oxide Synthase Type I; EC 1.14.99.3 / Heme Oxygenase-1; EC 2.7.11.12 / Cyclic GMP-Dependent Protein Kinases
  • [Other-IDs] NLM/ PMC2941487
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16. Nicholson HS, Kretschmar CS, Krailo M, Bernstein M, Kadota R, Fort D, Friedman H, Harris MB, Tedeschi-Blok N, Mazewski C, Sato J, Reaman GH: Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group. Cancer; 2007 Oct 1;110(7):1542-50
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  • Temozolomide, an agent with activity against adult brain tumors, was investigated in children and adolescents with recurrent CNS tumors.
  • PRs occurred in 1 of 23 evaluable patients with high-grade astrocytoma, 1 of 21 with low-grade astrocytoma, and 3 of 25 with medulloblastoma/primitive neuroectodermal tumor (PNET).
  • No responses were observed in patients with ependymoma, brain-stem glioma, or other CNS tumors.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Administration, Oral. Adolescent. Adult. Astrocytoma / drug therapy. Central Nervous System Neoplasms / drug therapy. Child. Child, Preschool. Drug Administration Schedule. Ependymoma / drug therapy. Female. Humans. Infant. Male. Medulloblastoma / drug therapy. Neuroectodermal Tumors, Primitive / drug therapy. Treatment Outcome


17. Hruska M, Keefe J, Wert D, Tekinay AB, Hulce JJ, Ibañez-Tallon I, Nishi R: Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. J Neurosci; 2009 Nov 25;29(47):14847-54
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  • [Title] Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons.
  • Vertebrate alpha-bungarotoxin-like molecules of the Ly-6 superfamily have been implicated as balancers of activity and survival in the adult nervous system.
  • One of these genes, an ortholog of prostate stem cell antigen (psca), is barely detectable at embryonic day (E) 8, before neuronal cell loss in the ciliary ganglion, but increases >100-fold as the number of neurons begins to decline between E9 and E14.

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  • (PMID = 19940180.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / R01 DA017784; United States / NIDA NIH HHS / DA / DA017784-04; United States / NIDA NIH HHS / DA / R01 DA017784-03; United States / NIDA NIH HHS / DA / DA17784; United States / NIDA NIH HHS / DA / R01 DA017784-02; United States / NCRR NIH HHS / RR / P20 RR016435; United States / NIDA NIH HHS / DA / DA017784-03; United States / NIDA NIH HHS / DA / DA017784-02; United States / NCRR NIH HHS / RR / 5 P20 RR016435; United States / NIDA NIH HHS / DA / R01 DA017784-04; United States / NIDA NIH HHS / DA / R01 DA017784-01A2; United States / NIDA NIH HHS / DA / DA017784-01A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Avian Proteins; 0 / Chrna7 protein, mouse; 0 / GPI-Linked Proteins; 0 / Lynx1 protein, mouse; 0 / Lynx2 protein, mouse; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / Neuropeptides; 0 / Neurotoxins; 0 / Nicotinic Agonists; 0 / Nicotinic Antagonists; 0 / Psca protein, mouse; 0 / Receptors, Nicotinic; 0 / alpha7 Nicotinic Acetylcholine Receptor
  • [Other-IDs] NLM/ NIHMS174829; NLM/ PMC2848080
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18. Meppiel E, Koumakis E, Cret C, Stefanizzi S, Béroud R, Améri A: [Cerebral radionecrosis after irradiation of a cancer of the cavum]. Rev Neurol (Paris); 2009 Sep;165 Spec No 3:F194-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Brain Injury, Chronic / etiology. Brain Stem / radiation effects. Carcinoma / radiotherapy. Cranial Irradiation / adverse effects. Gait Disorders, Neurologic / etiology. Hypesthesia / etiology. Nasopharyngeal Neoplasms / radiotherapy. Paresis / etiology. Radiation Injuries / etiology. Temporal Lobe / radiation effects
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Diagnosis, Differential. Epirubicin / administration & dosage. Female. Humans. Magnetic Resonance Imaging. Neoadjuvant Therapy. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 20222182.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 3Z8479ZZ5X / Epirubicin; Q20Q21Q62J / Cisplatin
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19. Prabhu K, Daniel RT, Mani S, Chacko AG: Dermoid tumor with diastematobulbia. Surg Neurol; 2009 Dec;72(6):717-21; discussion 721
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  • [Title] Dermoid tumor with diastematobulbia.
  • Dermoid tumor with diastematobulbia is very rare.
  • CASE DESCRIPTION: We report a dermoid tumor in an adult female with an unusual location and morphology.
  • The anterior part of the lesion was situated in the prepontine cistern and encircling the anterior half of the brainstem.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Cerebral Ventricle Neoplasms / surgery. Cisterna Magna / surgery. Dermoid Cyst / surgery. Fourth Ventricle / surgery. Medulla Oblongata / surgery. Neoplasms, Multiple Primary / surgery. Pons / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neural Tube Defects / diagnosis. Neural Tube Defects / pathology. Neural Tube Defects / surgery. Neurologic Examination. Postoperative Complications / diagnosis

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 19608253.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Qiu J, Ai L, Ramachandran C, Yao B, Gopalakrishnan S, Fields CR, Delmas AL, Dyer LM, Melnick SJ, Yachnis AT, Schwartz PH, Fine HA, Brown KD, Robertson KD: Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas. Lab Invest; 2008 Sep;88(9):910-25
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  • [Title] Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas.
  • Malignant gliomas are the most common primary brain tumors in adults and the second most common tumor in children.
  • Morbidity and mortality are high in glioma patients because tumors are resistant to treatment and are highly invasive into surrounding brain tissue rendering complete surgical resection impossible.
  • Here, we study the expression of cystatin E/M in normal brain and show that it is highly and moderately expressed in oligodendrocytes and astrocytes, respectively, but not in neurons.
  • In contrast, 78% of 28 primary brain tumors demonstrated reduced/absent cystatin E/M expression using a tissue microarray and this reduced expression correlated with CST6 promoter hypermethylation.
  • Interestingly, CST6 was expressed in neural stem cells (NSC) and markedly induced upon differentiation, whereas a glioma tumor initiating cell (TIC) line was completely blocked for CST6 expression by promoter methylation.
  • Analysis of primary pediatric brain tumor-derived lines also showed CST6 downregulation and methylation in nearly 100% of 12 cases.
  • These results demonstrate that epigenetic silencing of CST6 is frequent in adult and pediatric brain tumors and occurs in TICs, which are thought to give rise to the tumor.

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  • (PMID = 18607344.001).
  • [ISSN] 1530-0307
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA114229-04; United States / NCI NIH HHS / CA / R01 CA114229-03; United States / NCI NIH HHS / CA / R01 CA114229; United States / NCI NIH HHS / CA / CA114229-03; United States / NCI NIH HHS / CA / R01CA102289; United States / NCI NIH HHS / CA / R01 CA102289; United States / NCI NIH HHS / CA / CA114229-04; United States / NCI NIH HHS / CA / R01CA114229
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CST6 protein, human; 0 / Cystatin M; 0 / Cystatins; 0 / DNA Primers
  • [Other-IDs] NLM/ NIHMS59304; NLM/ PMC2574902
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21. Gururangan S, Krauser J, Watral MA, Driscoll T, Larrier N, Reardon DA, Rich JN, Quinn JA, Vredenburgh JJ, Desjardins A, McLendon RE, Fuchs H, Kurtzberg J, Friedman HS: Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. Neuro Oncol; 2008 Oct;10(5):745-51
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  • Nineteen patients (7 who received no RT before recurrence [group A] and 12 who received definitive RT before recurrence [group B]) underwent surgery and/or induction chemotherapy followed by HDC plus autologous stem-cell rescue.
  • All patients in groups B and C have died of tumor, at a median of 35 months and 26 months from HDC and standard salvage therapy, respectively.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Salvage Therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Humans. Kaplan-Meier Estimate. Retrospective Studies


22. Zhang M, Song T, Yang L, Chen R, Wu L, Yang Z, Fang J: Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients. J Exp Clin Cancer Res; 2008;27:85
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  • [Title] Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients.
  • AIM: Gliomas represent the most frequent neoplasm of the central nervous system.
  • Unfortunately, surgical cure of it is practically impossible and their clinical course is primarily determined by the biological behaviors of the tumor cells.
  • The aim of this study was to investigate the correlation of the stem cell markers Nestin and CD133 expression with the grading of gliomas, and to evaluate their prognostic value.
  • METHODS: The tissue samples consisted of 56 low- (WHO grade II), 69 high- (WHO grade III, IV) grade gliomas, and 10 normal brain tissues.
  • RESULTS: Immunohistochemical analysis with anti-Nestin and anti-CD133 antibodies revealed dense and spotty staining in the tumor cells and their expression levels became significantly higher as the glioma grade advanced (p < 0.05).
  • A combined detection of Nestin/CD133 co-expression may benefit us in the prediction of aggressive nature of this tumor.
  • [MeSH-major] Antigens, CD / biosynthesis. Biomarkers, Tumor / biosynthesis. Brain Neoplasms / metabolism. Glioma / metabolism. Glycoproteins / biosynthesis. Intermediate Filament Proteins / biosynthesis. Neoplastic Stem Cells / metabolism. Nerve Tissue Proteins / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged. Nestin. Peptides. Prognosis. Young Adult

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  • (PMID = 19108713.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Peptides
  • [Other-IDs] NLM/ PMC2633002
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23. Liu Q, Liu R, Kashyap MV, Agarwal R, Shi X, Wang CC, Yang SH: Brainstem glioma progression in juvenile and adult rats. J Neurosurg; 2008 Nov;109(5):849-55
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  • [Title] Brainstem glioma progression in juvenile and adult rats.
  • OBJECT: Brainstem gliomas are common in children and have the worst prognosis of any brain tumor in this age group.
  • On the other hand, brainstem gliomas are rare in adults, and the authors of some clinical studies have suggested that this lesion behaves differently in adults than in children.
  • In the present study, the authors test an orthotopic C6 brainstem glioma model in juvenile and adult rats, and investigate the biological behavior of this lesion in the 2 age groups.
  • METHODS: The C6 glioma cells were stereotactically implanted into the pons of juvenile or adult male rats.
  • Tumor proliferation and the number of apoptotic cells in brainstem gliomas of young and adult rats were determined by immunohistochemical staining with Ki 67 and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate-mediated nick-end labeling assay.
  • RESULTS: Striking differences in the onset of neurological signs, duration of symptoms, survival time, tumor growth pattern, tumor proliferation, and number of apoptotic cells were found between the gliomas in the 2 groups of rats.
  • The lesions were relatively focal in adult rats but more diffuse in young rats.
  • Furthermore, brainstem gliomas in adult rats were less proliferative and had more apoptotic cells than those in young rats.
  • CONCLUSIONS: The authors found that the C6 brainstem glioma model in young and adult rats closely imitates the course of brainstem glioma in humans both in neurological findings and histopathological characteristics.
  • Their findings also suggest that the different growth pattern and invasiveness of these lesions in children compared with that in adults could be due to different cellular environments in the 2 age groups, and warrants further investigation into the difference in the host response to brainstem gliomas in children and adults.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Glioma / pathology
  • [MeSH-minor] Age Factors. Animals. Apoptosis. Cell Line, Tumor. Cell Proliferation. Disease Models, Animal. Disease Progression. Kaplan-Meier Estimate. Male. Neoplasm Transplantation / pathology. Rats. Rats, Sprague-Dawley

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  • (PMID = 18976074.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS054651; United States / NINDS NIH HHS / NS / R01 NS054651-01A2; United States / NINDS NIH HHS / NS / R01 NS054687; United States / NINDS NIH HHS / NS / R01 NS054687-01A2
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS75237; NLM/ PMC2693119
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24. Nass D, Rosenwald S, Meiri E, Gilad S, Tabibian-Keissar H, Schlosberg A, Kuker H, Sion-Vardy N, Tobar A, Kharenko O, Sitbon E, Lithwick Yanai G, Elyakim E, Cholakh H, Gibori H, Spector Y, Bentwich Z, Barshack I, Rosenfeld N: MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors. Brain Pathol; 2009 Jul;19(3):375-83
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  • [Title] MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors.
  • A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a primary tumor or a metastasis from some other tissue.
  • The accurate diagnosis of brain malignancies is essential for selection of proper treatment.
  • Using microRNA expression profiling, we found that hsa-miR-92b and hsa-miR-9/hsa-miR-9* are over-expressed, specifically in brain primary tumors, as compared to primary tumors from other tissues and their metastases to the brain.
  • By considering the expression of only these two microRNAs, it is possible to distinguish between primary and metastatic brain tumors with very high accuracy.
  • These microRNAs thus represent excellent biomarkers for brain primary tumors.
  • Previous reports have found that hsa-miR-92b and hsa-miR-9/hsa-miR-9* are expressed more strongly in developing neurons and brain than in adult brain.
  • Thus, their specific over-expression in brain primary tumors supports a functional role for these microRNAs or a link between neuronal stem cells and brain tumorigenesis.
  • [MeSH-major] Biomarkers, Tumor / genetics. Brain Neoplasms / diagnosis. Brain Neoplasms / genetics. MicroRNAs / genetics. Neoplasm Metastasis / diagnosis
  • [MeSH-minor] Adult. Area Under Curve. Diagnosis, Differential. Gene Expression. Humans. Oligonucleotide Array Sequence Analysis. ROC Curve. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 18624795.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MicroRNAs
  • [Other-IDs] NLM/ PMC2728890
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25. Glas M, Rath BH, Simon M, Reinartz R, Schramme A, Trageser D, Eisenreich R, Leinhaas A, Keller M, Schildhaus HU, Garbe S, Steinfarz B, Pietsch T, Steindler DA, Schramm J, Herrlinger U, Brüstle O, Scheffler B: Residual tumor cells are unique cellular targets in glioblastoma. Ann Neurol; 2010 Aug;68(2):264-9
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  • [Title] Residual tumor cells are unique cellular targets in glioblastoma.
  • Residual tumor cells remain beyond the margins of every glioblastoma (GBM) resection.
  • In this study, residual tumor cells were derived via experimental biopsy of the resection margin after standard neurosurgery for direct comparison with samples from the routinely resected tumor tissue.
  • In vitro analysis of proliferation, invasion, stem cell qualities, GBM-typical antigens, genotypes, and in vitro drug and irradiation challenge studies revealed these cells as unique entities.
  • Our findings suggest a need for characterization of residual tumor cells to optimize diagnosis and treatment of GBM.

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  • (PMID = 20695020.001).
  • [ISSN] 1531-8249
  • [Journal-full-title] Annals of neurology
  • [ISO-abbreviation] Ann. Neurol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS055165; United States / NINDS NIH HHS / NS / NS055165
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
  • [Other-IDs] NLM/ NIHMS686096; NLM/ PMC4445859
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26. Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin D, Black KL, Yu JS: Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer; 2006 Dec 02;5:67
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  • [Title] Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.
  • BACKGROUND: Recently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified.
  • Some evidence has suggested that CD133 is a marker for a subset of leukemia and glioblastoma cancer stem cells.
  • The gene expression and the drug resistance property of CD133 positive cancer stem cells, however, are still unknown.
  • CONCLUSION: Our study for the first time provided evidence that CD133 positive cancer stem cells display strong capability on tumor's resistance to chemotherapy.
  • Future treatment should target this small population of CD133 positive cancer stem cells in tumors to improve the survival of brain tumor patients.

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  • (PMID = 17140455.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS048959; United States / NINDS NIH HHS / NS / K23 NS002232; United States / NINDS NIH HHS / NS / 1R21 NS048879; United States / NINDS NIH HHS / NS / R21 NS048879; United States / NINDS NIH HHS / NS / 1R01 NS048959; United States / NINDS NIH HHS / NS / 1K23NS02232
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Antineoplastic Agents; 0 / Glycoproteins; 0 / Peptides; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC1697823
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27. Metz RL, Patel PS, Hameed M, Bryan M, Rameshwar P: Role of human HGFIN/nmb in breast cancer. Breast Cancer Res; 2007;9(5):R58
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  • These seemingly opposing roles of HGFIN suggest that this protein might be central to malignancies and might also behave as a tumor suppressor.
  • CONCLUSION: As the majority of cancer cells have mutations in p53, further studies on the relationship between p53 and HGFIN expression, and its role in tumor genesis and bone invasion, might uncover novel therapy targets for breast and other cancers.
  • [MeSH-minor] 5' Flanking Region / genetics. Adult. Aged. Blotting, Northern. Blotting, Western. Cell Differentiation. Cell Movement. Cells, Cultured. Colony-Forming Units Assay. Female. Gene Expression Regulation, Neoplastic. Genes, Reporter. Humans. In Situ Hybridization. Membrane Glycoproteins. Middle Aged. Mutation. Neoplasm Invasiveness / pathology. RNA, Small Interfering / genetics. Reverse Transcriptase Polymerase Chain Reaction. Tumor Suppressor Protein p53 / physiology

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  • (PMID = 17845721.001).
  • [ISSN] 1465-542X
  • [Journal-full-title] Breast cancer research : BCR
  • [ISO-abbreviation] Breast Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GPNMB protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / RNA, Small Interfering; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2242655
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28. Schmidt M, Simon T, Hero B, Eschner W, Dietlein M, Sudbrock F, Bongartz R, Berthold F, Schicha H: Is there a benefit of 131 I-MIBG therapy in the treatment of children with stage 4 neuroblastoma? A retrospective evaluation of The German Neuroblastoma Trial NB97 and implications for The German Neuroblastoma Trial NB2004. Nuklearmedizin; 2006;45(4):145-51; quiz N39-40
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  • However, subgroup analysis of 66 patients who underwent high dose chemotherapy with autologous stem cell transplantation (ASCT) during treatment found a very similar outcome with (131)I-MIBG therapy (3-y-EFS 49 +/- 9%, 3-y-OS 59 +/- 10%) and without (131)I-MIBG therapy (3-y-EFS 33 +/- 9%, p = 0.171; 3-y-OS 59 +/- 9%, p = 0.285) due to the dominating effect of ASCT.
  • [MeSH-major] 3-Iodobenzylguanidine / therapeutic use. Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy. Iodine Radioisotopes / therapeutic use. Neuroblastoma / drug therapy. Neuroblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Follow-Up Studies. Humans. Neoplasm Staging. Regression Analysis. Retrospective Studies. Survival Analysis. Treatment Outcome


29. Lee HY, Kim KM, Kang MH, Kang JH, Kang KM, Lee GW: Concurrent craniospinal radiotherapy and intrathecal chemotherapy in patient with acute promyelocytic leukemia second relapsed in central nervous system (CNS) following allogeneic stem cell transplantation. J Neurooncol; 2006 Aug;79(1):73-5
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  • [Title] Concurrent craniospinal radiotherapy and intrathecal chemotherapy in patient with acute promyelocytic leukemia second relapsed in central nervous system (CNS) following allogeneic stem cell transplantation.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Brain Neoplasms / therapy. Cranial Irradiation. Leukemia, Promyelocytic, Acute / therapy. Neoplasm Recurrence, Local / therapy. Stem Cell Transplantation
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Injections, Spinal. Male


30. Shah GD, Silver JS, Rosenfeld SS, Gavrilovic IT, Abrey LE, Lassman AB: Myelosuppression in patients benefiting from imatinib with hydroxyurea for recurrent malignant gliomas. J Neurooncol; 2007 Nov;85(2):217-22
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  • Disease control may also correlate with hematologic toxicity (p = 0.08), suggesting that glioma and marrow stem cells may share a common sensitivity to this chemotherapy regimen.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Bone Marrow Diseases / chemically induced. Brain Neoplasms / drug therapy. Glioblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Aged. Benzamides. Bone Marrow / drug effects. Humans. Hydroxyurea / administration & dosage. Imatinib Mesylate. Male. Middle Aged. Nucleic Acid Synthesis Inhibitors / administration & dosage. Piperazines / administration & dosage. Protein Kinase Inhibitors / administration & dosage. Protein-Tyrosine Kinases / antagonists & inhibitors. Pyrimidines / administration & dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 17594055.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzamides; 0 / Nucleic Acid Synthesis Inhibitors; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases; X6Q56QN5QC / Hydroxyurea
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31. Fischer I, Cunliffe CH, Bollo RJ, Raza S, Monoky D, Chiriboga L, Parker EC, Golfinos JG, Kelly PJ, Knopp EA, Gruber ML, Zagzag D, Narayana A: High-grade glioma before and after treatment with radiation and Avastin: initial observations. Neuro Oncol; 2008 Oct;10(5):700-8
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  • Histological analysis focused on microvessel density and vascular morphology, and expression patterns of vascular endothelial growth factor-A (VEGF-A) and the hematopoietic stem cell, mesenchymal, and cell motility markers CD34, smooth muscle actin, D2-40, and fascin.
  • VEGF-A expression in tumor cells was increased in two cases and decreased in three and did not correlate with treatment response.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antibodies, Monoclonal / therapeutic use. Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy. Glioma / drug therapy. Glioma / radiotherapy
  • [MeSH-minor] Actins / drug effects. Actins / radiation effects. Adult. Antibodies, Monoclonal, Humanized. Antigens, CD34 / drug effects. Antigens, CD34 / radiation effects. Bevacizumab. Carrier Proteins / drug effects. Carrier Proteins / radiation effects. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Male. Microfilament Proteins / drug effects. Microfilament Proteins / radiation effects. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Retrospective Studies. Vascular Endothelial Growth Factor A / drug effects. Vascular Endothelial Growth Factor A / radiation effects

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  • (PMID = 18697955.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antigens, CD34; 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 146808-54-0 / fascin; 2S9ZZM9Q9V / Bevacizumab
  • [Other-IDs] NLM/ PMC2666246
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32. Geoerger B, Vassal G, Doz F, O'Quigley J, Wartelle M, Watson AJ, Raquin MA, Frappaz D, Chastagner P, Gentet JC, Rubie H, Couanet D, Geoffray A, Djafari L, Margison GP, Pein F: Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies. Br J Cancer; 2005 Sep 5;93(5):529-37
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  • Hearing loss was experienced in five patients with prior irradiation to the brain stem or posterior fossa.
  • Partial responses were observed in two malignant glioma, one brain stem glioma, and two neuroblastoma.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Cisplatin / administration & dosage. Dacarbazine / administration & dosage. Dacarbazine / analogs & derivatives. Drug Resistance, Neoplasm. Female. Humans. Infant. Male. Maximum Tolerated Dose. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Salvage Therapy. Treatment Outcome

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  • (PMID = 16136028.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ PMC2361608
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33. Erreni M, Solinas G, Brescia P, Osti D, Zunino F, Colombo P, Destro A, Roncalli M, Mantovani A, Draghi R, Levi D, Rodriguez Y Baena R, Gaetani P, Pelicci G, Allavena P: Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1. Eur J Cancer; 2010 Dec;46(18):3383-92
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  • [Title] Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1.
  • The most severe form, the glioblastoma multiforme, is characterised by a marked and diffuse infiltration through the normal brain parenchyma.
  • Glioblastoma-derived neurospheres, containing a mixed population of stem and progenitor cells, were positive for both CX3CR1 and for the membrane-bound chemokine, which was further up-regulated and secreted after TNF-IFNγ stimulation.
  • [MeSH-major] Brain Neoplasms / metabolism. Chemokine CX3CL1 / metabolism. Glioblastoma / metabolism. Neoplasm Proteins / metabolism. Neoplastic Stem Cells / metabolism. Receptors, Interleukin-8A / metabolism
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Tumor Cells, Cultured

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20728344.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chemokine CX3CL1; 0 / Neoplasm Proteins; 0 / Receptors, Interleukin-8A
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34. Gilheeney SW, Khakoo Y, Souweidane M, Wolden S, Boulad F, Dunkel IJ: Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognosis pediatric malignancies of the central nervous system. Pediatr Blood Cancer; 2010 Apr;54(4):591-5
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  • [Title] Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognosis pediatric malignancies of the central nervous system.
  • Topotecan potentiates the anti-cancer effects of alkylators and crosses the blood-brain barrier.
  • Stem cell rescue was on day 0.
  • Four of the seven patients with no evidence of disease/minimal residual disease status at the time of stem cell rescue are long-term survivors versus 1/3 with measurable disease.
  • Diagnosis and extent of disease prior to stem cell rescue may have an impact on outcome.
  • [MeSH-minor] Adolescent. Carboplatin / administration & dosage. Carboplatin / adverse effects. Child. Child, Preschool. Combined Modality Therapy. Female. Hematopoietic Stem Cell Transplantation. Humans. Male. Neoplasm Recurrence, Local / drug therapy. Prognosis. Thiotepa / administration & dosage. Thiotepa / adverse effects. Topotecan / administration & dosage. Topotecan / adverse effects. Young Adult

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  • (PMID = 19998470.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 7M7YKX2N15 / Topotecan; 905Z5W3GKH / Thiotepa; BG3F62OND5 / Carboplatin
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35. Owonikoko T, Agha M, Balassanian R, Smith R, Raptis A: Gemtuzumab therapy for isolated extramedullary AML relapse following allogeneic stem-cell transplant. Nat Clin Pract Oncol; 2007 Aug;4(8):491-5
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  • [Title] Gemtuzumab therapy for isolated extramedullary AML relapse following allogeneic stem-cell transplant.
  • He received consolidation therapy 3 months later with a matched-unrelated-donor stem-cell transplant.
  • The disease relapsed in the bone marrow (BM) 9 months after the initial stem-cell transplant, and was successfully treated by repeat transplant from the same donor.
  • INVESTIGATIONS: Physical examination, complete blood count, BM biopsy, flow cytometry, cytogenetic analysis, chimera study, tongue biopsy, abdominal-wall biopsy, cytology and immunohistochemistry, CT scan of the chest, abdomen and pelvis, MRI of the brain, and cerebrospinal fluid analysis.
  • DIAGNOSIS: Isolated extramedullary relapse of acute myeloid leukemia after stem-cell transplant.
  • A matched-unrelated-donor stem-cell transplant for consolidation and donor-lymphocyte infusions were performed, followed by repeat unrelated-donor transplant for leukemia relapse in the marrow, radiation therapy and gemtuzumab ozogamicin for multiple sites of extramedullary leukemia relapse.
  • [MeSH-major] Aminoglycosides / therapeutic use. Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Hematopoietic Stem Cell Transplantation / adverse effects. Neoplasm Recurrence, Local / drug therapy. Sarcoma, Myeloid / drug therapy
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Humanized. Humans. Male

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  • (PMID = 17657254.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminoglycosides; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / gemtuzumab
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36. Joo KM, Kim SY, Jin X, Song SY, Kong DS, Lee JI, Jeon JW, Kim MH, Kang BG, Jung Y, Jin J, Hong SC, Park WY, Lee DS, Kim H, Nam DH: Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab Invest; 2008 Aug;88(8):808-15
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  • A number of recent reports have demonstrated that only CD133-positive cancer cells of glioblastoma multiforme (GBM) have tumor-initiating potential.
  • These findings raise an attractive hypothesis that GBMs can be cured by eradicating CD133-positive cancer stem cells (CSCs), which are a small portion of GBM cells.
  • Both CD133-positive and CD133-negative cells purified from four out of six GBM patients produced typical GBM tumor masses in NOD-SCID brains, whereas brain mass from CD133-negative cells showed more proliferative and angiogenic features compared to that from CD133-positive cells.
  • Our results suggest, in contrast to previous reports that only CD133-positive cells of GBMs can initiate tumor formation in vivo CD133-negative cells also possess tumor-initiating potential, which is indicative of complexity in the identification of cancer cells for therapeutic targeting.
  • [MeSH-major] Antigens, CD / metabolism. Brain Neoplasms / immunology. Glioblastoma / immunology. Glycoproteins / metabolism. Neoplastic Stem Cells / immunology. Peptides / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Animals. Brain / pathology. Cells, Cultured. Drug Resistance, Neoplasm / immunology. Female. Gene Expression Profiling. Humans. Male. Mice. Mice, SCID. Middle Aged

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  • (PMID = 18560366.001).
  • [ISSN] 1530-0307
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Glycoproteins; 0 / Peptides
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37. Shuto T, Inomori S, Matsunaga S, Fujino H: Microsurgery for vestibular schwannoma after gamma knife radiosurgery. Acta Neurochir (Wien); 2008 Mar;150(3):229-34; discussion 234
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  • Adhesion to the brain stem was severe in 7 patients.
  • Dissection of the tumour from the facial nerve or brain stem is likely to be difficult.
  • [MeSH-minor] Adult. Aged. Dissection / methods. Dissection / standards. Ear, Inner / anatomy & histology. Ear, Inner / pathology. Ear, Inner / surgery. Facial Nerve / pathology. Facial Nerve / physiopathology. Facial Nerve / surgery. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / prevention & control. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Neurosurgical Procedures / statistics & numerical data. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Retrospective Studies. Treatment Failure. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / physiopathology. Trigeminal Nerve / surgery

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  • (PMID = 18253695.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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38. Fangusaro J: Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas. J Child Neurol; 2009 Nov;24(11):1409-17
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  • Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors.
  • Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy.
  • [MeSH-major] Brain Neoplasms. Brain Stem Neoplasms. Glioma
  • [MeSH-minor] Child. Humans. Models, Neurological. Neoplasm Staging

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  • (PMID = 19638636.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 83
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39. Pisati F, Belicchi M, Acerbi F, Marchesi C, Giussani C, Gavina M, Javerzat S, Hagedorn M, Carrabba G, Lucini V, Gaini SM, Bresolin N, Bello L, Bikfalvi A, Torrente Y: Effect of human skin-derived stem cells on vessel architecture, tumor growth, and tumor invasion in brain tumor animal models. Cancer Res; 2007 Apr 1;67(7):3054-63
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  • [Title] Effect of human skin-derived stem cells on vessel architecture, tumor growth, and tumor invasion in brain tumor animal models.
  • New experimental approaches have shown tumor regression after the grafting of neural stem cells and human mesenchymal stem cells into experimental intracranial gliomas of adult rodents.
  • In the present study, we evaluated the tumor targeting and antitumor activity of human skin-derived stem cells (hSDSCs) in human brain tumor models.
  • The hSDSCs exhibit tumor targeting characteristics in vivo when injected into the controlateral hemisphere or into the tail vein of mice.
  • When implanted directly into glioblastomas, hSDSCs distributed themselves extensively throughout the tumor mass, reduced tumor vessel density, and decreased angiogenic sprouts.
  • In addition, transplanted hSDSCs differentiate into pericyte cell and release high amounts of human transforming growth factor-beta1 with low expression of vascular endothelial growth factor, which may contribute to the decreased tumor cell invasion and number of tumor vessels.
  • In long-term experiments, the hSDSCs were also able to significantly inhibit tumor growth and to prolong animal survival.
  • Similar behavior was seen when hSDSCs were implanted into two different tumor models, the chicken embryo experimental glioma model and the transgenic Tyrp1-Tag mice.
  • Taken together, these data validate the use of hSDSCs for targeting human brain tumors.
  • [MeSH-major] Brain Neoplasms / blood supply. Brain Neoplasms / therapy. Glioblastoma / blood supply. Glioblastoma / therapy. Skin / cytology. Stem Cell Transplantation. Stem Cells / physiology
  • [MeSH-minor] Animals. Cell Growth Processes / physiology. Cell Line, Tumor. Chick Embryo. Chorioallantoic Membrane / blood supply. Humans. Mice. Mice, Nude. Mice, Transgenic. Neoplasm Invasiveness. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Neovascularization, Pathologic / therapy. Transforming Growth Factor beta1 / biosynthesis. Xenograft Model Antitumor Assays

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  • (PMID = 17409412.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta1
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40. Kozić D, Nagulić M, Samardzić M, Ostojić J, Rasulić L, Cvetković-Dozić D: Intrapontine malignant nerve sheath tumor: MRI and MRS features. Acta Neurol Belg; 2008 Jun;108(2):67-71
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  • [Title] Intrapontine malignant nerve sheath tumor: MRI and MRS features.
  • The primary source of malignant intracerebral nerve sheath tumors is still unclear We report the imaging and MR spectroscopic findings in a 39-year-old man with a very rare brain stem tumor MR examination revealed the presence of intraaxial brain stem tumor with a partial exophytic growth.
  • On pathological examination, the neoplasm appeared to be an intrapontine nerve sheath tumor originating most likely from the intrapontine segment of one of the cranial nerve fibres.
  • The tumor showed exophytic growth, with consequent spread to adjacent subaracnoid space.
  • [MeSH-major] Brain Neoplasms / pathology. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy. Nerve Sheath Neoplasms / pathology. Pons / pathology
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 18795600.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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41. Michor F: Mathematical models of cancer stem cells. J Clin Oncol; 2008 Jun 10;26(17):2854-61
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  • [Title] Mathematical models of cancer stem cells.
  • Human cancers are thought to be sustained in their growth by a pathologic counterpart of normal adult stem cells: cancer stem cells.
  • This concept was first developed in human myeloid leukemias and is today being extended to solid tumors such as breast and brain cancers.
  • A quantitative understanding of cancer stem cells requires a mathematical framework to describe the dynamics of cancer initiation and progression, the response to treatment, and the evolution of resistance.
  • In this review, I use chronic myeloid leukemia as an example to discuss how mathematical and computational techniques have been used to gain insights into the biology of cancer stem cells.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Models, Biological. Neoplastic Stem Cells / pathology
  • [MeSH-minor] Antineoplastic Agents / pharmacology. Antineoplastic Agents / therapeutic use. Benzamides. Cell Differentiation. Cell Proliferation. Drug Resistance, Neoplasm. Gene Expression Regulation, Leukemic. Humans. Imatinib Mesylate. Mutation. Patient Selection. Piperazines / pharmacology. Piperazines / therapeutic use. Protein Kinase Inhibitors / pharmacology. Protein Kinase Inhibitors / therapeutic use. Pyrimidines / pharmacology. Pyrimidines / therapeutic use. Time Factors

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  • (PMID = 18539964.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
  • [Number-of-references] 65
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42. Moviglia GA, Carrizo AG, Varela G, Gaeta CA, Paes de Lima A, Farina P, Molina H: Preliminary report on tumor stem cell/B cell hybridoma vaccine for recurrent glioblastoma multiforme. Hematol Oncol Stem Cell Ther; 2008 Jan-Mar;1(1):3-13
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  • [Title] Preliminary report on tumor stem cell/B cell hybridoma vaccine for recurrent glioblastoma multiforme.
  • BACKGROUND: Glioblastoma multiforme (GBM), the most aggressive glioma, presents with a rapid evolution and relapse within the first year, which is attributed to the persistence of tumor stem cells (TSC) and the escape of immune surveillance.
  • Tumor B-cell hybridoma (TBH) vaccines have been shown to function as antigen-presenting cells.
  • RESULTS: Treatment with MLC had strong and rapid therapeutic effects, but was limited in duration and induced various degrees of brain inflammation.
  • Treatment with MLC+TBH acted synergistically, provoking a rapid, strong and lasting therapeutic response but also generating different degrees of brain inflammation.
  • A lasting therapeutic effect without generating high degrees of brain inflammation occurred in patients treated with TBH vaccine alone.
  • CONCLUSION: TSC vaccine consisting of TBH alone seems to have potent adjuvant reactions overcoming both persistence of tumor stem cells and immune escape of GBM without provoking an encephalitic reaction.
  • [MeSH-major] B-Lymphocytes / transplantation. Brain Neoplasms / therapy. Cancer Vaccines / therapeutic use. Glioblastoma / therapy. Hybridomas / transplantation. Neoplastic Stem Cells / transplantation
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Leukocytes, Mononuclear / immunology. Leukocytes, Mononuclear / transplantation. Lymphocyte Culture Test, Mixed. Male. Middle Aged. Neoplasm Recurrence, Local / therapy

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  • (PMID = 20063522.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cancer Vaccines
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43. Saldanha-Araujo F, Haddad R, Zanette DL, De Araujo AG, Orellana MD, Covas DT, Zago MA, Panepucci RA: Cancer/Testis antigen expression on mesenchymal stem cells isolated from different tissues. Anticancer Res; 2010 Dec;30(12):5023-7
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  • [Title] Cancer/Testis antigen expression on mesenchymal stem cells isolated from different tissues.
  • BACKGROUND/AIMS: The expression of cancer/testis antigens (CTAs) on additional normal tissues or stem cells may restrict their use as cancer targets.
  • MATERIALS AND METHODS: mRNA of pericytes, fibroblasts and mesenchymal stem cells (MSCs) derived from adult and fetal tissues, human umbilical vein endothelial cells, MSC-derived adipocytes, selected normal tissues and control cancer cell lines (CLs) were extracted and quantitative polymerase chain reaction was performed for MAGED1, PRAME, CTAG1B, MAGEA3 and MAGEA4.
  • CTAG1B was expressed at levels comparable to control CLs on MSCs derived from arterial, fetal skin, adipose tissue and saphenous vein, heart, brain and skin tissues.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Mesenchymal Stromal Cells / immunology
  • [MeSH-minor] Fibroblasts / immunology. Humans. Immunophenotyping. Melanoma-Specific Antigens. Membrane Proteins / biosynthesis. Neoplasm Proteins / biosynthesis. Pericytes / immunology

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  • (PMID = 21187485.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / MAGEA1 protein, human; 0 / MAGEA3 protein, human; 0 / MAGEA4 protein, human; 0 / MAGED1 protein, human; 0 / Melanoma-Specific Antigens; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / PRAME protein, human
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44. Kawataki T, Sato E, Sato T, Kinouchi H: Anaplastic ganglioglioma with malignant features in both neuronal and glial components--case report. Neurol Med Chir (Tokyo); 2010;50(3):228-31
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  • The tumor was subtotally removed, followed by irradiation and chemotherapy.
  • Though these cells were weakly positive for synaptophysin and glial fibrillary acidic protein, the neural stem cell marker nestin was extremely expressed in both these cells.
  • Two months later, the tumor recurred with more pleomorphic appearance and higher cellularity with increased nestin expression level.
  • The expression of nestin may suggest that the origin or malignant transformation in anaplastic gangliogliomas is related to the undifferentiated neural stem cells.
  • [MeSH-major] Brain Neoplasms / pathology. Ganglioglioma / pathology. Intermediate Filament Proteins / metabolism. Neoplasm Proteins / metabolism. Nerve Tissue Proteins / metabolism. Neuroglia / pathology. Neurons / pathology
  • [MeSH-minor] Adult. Anaplasia. Fatal Outcome. Humans. Male. Neoplasm Recurrence, Local. Nestin. Seizures / etiology. Seizures / pathology. Temporal Lobe / cytology. Temporal Lobe / metabolism. Temporal Lobe / pathology

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  • (PMID = 20339274.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Nestin
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45. Chu L, Huang Q, Zhai DZ, Zhu Q, Huo HM, Dong J, Qian ZY, Wang AD, Lan Q, Gao YL: [Expression and significance of ABCG2 in human malignant glioma]. Ai Zheng; 2007 Oct;26(10):1090-4
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  • BACKGROUND & OBJECTIVE: ATP-binding cassette transporter protein ABCG2 is a marker derived from hematopoietic stem cells.
  • METHODS: A microarray chip containing glioma tissues of different malignant grades, implanted glioma xenografts in nude mice, spheroids of glioma cell lines and glioma stem cells was prepared and examined for the expression of ABCG2 with immunohistochemical staining.
  • The positive rate of ABCG2 was 100% in implanted glioma xenografts in nude mice, gliomas stem cells, and neural stem cells.
  • CONCLUSIONS: ABCG2 is overexpressed in glioma stem cells, glioma tissues of higher grades, and implanted glioma xenografts.
  • [MeSH-major] ATP-Binding Cassette Transporters / metabolism. Brain Neoplasms / metabolism. Glioma / metabolism. Neoplasm Proteins / metabolism. Neoplastic Stem Cells / metabolism
  • [MeSH-minor] ATP Binding Cassette Transporter, Sub-Family G, Member 2. Adolescent. Adult. Aged. Aged, 80 and over. Animals. Bone Marrow Cells / metabolism. Brain / metabolism. Brain / pathology. Cell Line, Tumor. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Mice. Mice, Nude. Middle Aged. Neoplasm Transplantation. Stem Cells / metabolism. Tissue Array Analysis. Young Adult

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  • (PMID = 17927879.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / ATP Binding Cassette Transporter, Sub-Family G, Member 2; 0 / ATP-Binding Cassette Transporters; 0 / Neoplasm Proteins
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46. Huang AP, Chen JS, Yang CC, Wang KC, Yang SH, Lai DM, Tu YK: Brain stem cavernous malformations. J Clin Neurosci; 2010 Jan;17(1):74-9
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  • [Title] Brain stem cavernous malformations.
  • We retrospectively reviewed the clinical experience of 30 patients with brain stem cavernous malformations (BSCM) treated operatively and non-operatively at our hospital between 1983 and 2005 to elucidate the natural history of BSCM and the factors that affect surgical outcome.
  • [MeSH-major] Brain Stem / pathology. Brain Stem / surgery. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / surgery. Hemangioma, Cavernous, Central Nervous System / pathology. Hemangioma, Cavernous, Central Nervous System / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Stem Infarctions / etiology. Brain Stem Infarctions / physiopathology. Brain Stem Infarctions / prevention & control. Cerebral Arteries / abnormalities. Cerebral Arteries / pathology. Cerebral Arteries / surgery. Cerebral Veins / abnormalities. Cerebral Veins / pathology. Cerebral Veins / surgery. Child. Female. Humans. Intracranial Hemorrhages / etiology. Intracranial Hemorrhages / physiopathology. Intracranial Hemorrhages / prevention & control. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures / methods. Neurosurgical Procedures / statistics & numerical data. Outcome Assessment (Health Care). Postoperative Hemorrhage / epidemiology. Postoperative Hemorrhage / prevention & control. Retrospective Studies. Treatment Outcome. Young Adult

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20005720.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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47. Capitini CM, Derdak J, Hughes MS, Love CP, Baird K, Mackall CL, Fry TJ: Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantation. J Pediatr Hematol Oncol; 2009 Feb;31(2):142-4
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  • [Title] Unusual sites of extraskeletal metastases of Ewing sarcoma after allogeneic hematopoietic stem cell transplantation.
  • Allogeneic stem cell transplantation (SCT) for solid tumors remains under investigation.
  • Of note, the patient developed metastatic disease to 2 unusual sites-the brain and small intestine.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation / methods. Neoplasm Metastasis / pathology. Sarcoma, Ewing / pathology
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Humans. Intestinal Neoplasms / secondary. Male. Transplantation, Homologous. Treatment Failure

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  • (PMID = 19194203.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS87241; NLM/ PMC2644462
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48. Zhou J, Li NY, Zhou XJ, Zhou HB, Wu B, Jiang SJ, Ma HH, Zhang RS: [Clinicopathologic study of von Hippel-Lindau syndrome-related and sporadic hemangioblastomas of central nervous system]. Zhonghua Bing Li Xue Za Zhi; 2010 Mar;39(3):145-50
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  • There were 10 patients presenting other lesions related to VHL, including 6 retinal HBs, 4 pancreatic tumors (endocrine tumor and microcystic cystadenoma), 1 clear renal cell carcinoma, 4 renal cysts and 1 endolymphatic sac tumor.
  • Involvement of the brain tissue was seen in 32 cases, among which, 21 patients with available follow-up information were learnt to be alive.
  • Tumor cells of HB stained positive for vimentin, EGFR, Inhibin alpha and D2-40, but negative for CD34 and CD68.
  • The most common tumor is CNS-HB, which occurs predominantly in the cerebellum.
  • Patients with VHL syndrome tend to present at a younger age than patients with sporadic CNS-HBs, and VHL related HB occurs more predominantly in the brain stem and spinal cord.
  • Prognosis of CNS-HB patients is not correlated with the nuclear atypicality, expression for Ki-67 and involvement of the brain tissue.
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / surgery. Child. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / metabolism. Humans. Inhibins / metabolism. Ki-67 Antigen / metabolism. Male. Middle Aged. Neoplasm Recurrence, Local. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Receptor, Epidermal Growth Factor / metabolism. Retinal Neoplasms / metabolism. Retinal Neoplasms / pathology. Retinal Neoplasms / surgery. Survival Analysis. Vimentin / metabolism. Young Adult

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  • (PMID = 20450758.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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49. Farnie G, Clarke RB: Mammary stem cells and breast cancer--role of Notch signalling. Stem Cell Rev; 2007 Jun;3(2):169-75
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  • [Title] Mammary stem cells and breast cancer--role of Notch signalling.
  • Adult stem cells are found in numerous tissues of the body and play a role in tissue development, replacement and repair.
  • Evidence shows that breast stem cells are multipotent and can self renew, which are key characteristics of stem cells, and a single cell enriched with cell surface markers has the ability to grow a fully functional mammary gland in vivo.
  • Many groups have extrapolated the cancer stem cell hypothesis from the haematopoietic system to solid cancers, where using in vitro culture techniques and in vivo transplant models have established evidence of cancer stem cells in colon, pancreas, prostate, brain and breast cancers.
  • In the report we describe the evidence for breast cancer stem cells; studies consistently show that stem cell like and breast cancer initiating populations can be enriched using cell surface makers CD44+/CD24- and have upregulated genes which include Notch.
  • A gamma-secretase inhibitor, DAPT, which inhibits all four Notch receptors and a Notch 4 neutralising antibody were shown to reduce DCIS mammosphere formation, indicating that Notch signalling and other stem cell self-renewal pathways may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.
  • [MeSH-major] Breast Neoplasms / metabolism. Carcinoma, Intraductal, Noninfiltrating / metabolism. Mammary Glands, Human / metabolism. Multipotent Stem Cells / metabolism. Neoplastic Stem Cells / metabolism. Receptor, Notch1 / metabolism
  • [MeSH-minor] Amyloid Precursor Protein Secretases / antagonists & inhibitors. Amyloid Precursor Protein Secretases / metabolism. Animals. Antigens, CD24 / metabolism. Antigens, CD44 / metabolism. Biomarkers, Tumor / metabolism. Dipeptides / pharmacology. Enzyme Inhibitors / pharmacology. Female. Gene Expression Regulation, Neoplastic. Humans. Mammary Glands, Animal / metabolism. Mammary Glands, Animal / pathology. Mammary Neoplasms, Experimental / metabolism. Mammary Neoplasms, Experimental / pathology. Mammary Neoplasms, Experimental / prevention & control. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Transplantation. Spheroids, Cellular / metabolism. Spheroids, Cellular / pathology. Up-Regulation

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  • (PMID = 17873349.001).
  • [ISSN] 1550-8943
  • [Journal-full-title] Stem cell reviews
  • [ISO-abbreviation] Stem Cell Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD24; 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD24 protein, human; 0 / CD44 protein, human; 0 / Dipeptides; 0 / Enzyme Inhibitors; 0 / N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester; 0 / NOTCH1 protein, human; 0 / Receptor, Notch1; EC 3.4.- / Amyloid Precursor Protein Secretases
  • [Number-of-references] 58
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50. Bera TK, Saint Fleur A, Ha D, Yamada M, Lee Y, Lee B, Hahn Y, Kaufman DS, Pera M, Pastan I: Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells. Stem Cells Dev; 2008 Apr;17(2):325-32
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  • [Title] Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.
  • The expression of the POTE gene in normal adult tissues is restricted, but several POTE paralogs are frequently expressed in many cancers including breast, prostate, and lung cancers.
  • We show here that POTE is expressed in several human embryonic stem (ES) cell lines.

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  • (PMID = 18447647.001).
  • [ISSN] 1547-3287
  • [Journal-full-title] Stem cells and development
  • [ISO-abbreviation] Stem Cells Dev.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL077923-02; United States / NHLBI NIH HHS / HL / R01 HL077923; United States / NHLBI NIH HHS / HL / R01 HL077923-02; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / POTE-2alpha protein, human; 0 / POTE-2beta protein, human; 0 / POTE-2gamma protein, human; 0 / Protein Isoforms; 776B62CQ27 / decitabine; M801H13NRU / Azacitidine
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51. Gururangan S, Chi SN, Young Poussaint T, Onar-Thomas A, Gilbertson RJ, Vajapeyam S, Friedman HS, Packer RJ, Rood BN, Boyett JM, Kun LE: Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. J Clin Oncol; 2010 Jun 20;28(18):3069-75
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  • [Title] Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study.
  • PURPOSE: A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in children with recurrent malignant glioma (MG) and intrinsic brainstem glioma (BSG).
  • CONCLUSION: BVZ plus CPT-11 was well-tolerated but had minimal efficacy in children with recurrent malignant glioma and brainstem glioma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adolescent. Adult. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Bevacizumab. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Child. Diffusion Magnetic Resonance Imaging. Humans. Phosphorylation. Survival Rate. Treatment Outcome. Vascular Endothelial Growth Factor Receptor-2 / metabolism. Young Adult

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  • (PMID = 20479404.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000188; United States / NCI NIH HHS / CA / U01 CA081457; United States / NCRR NIH HHS / RR / M01RR00188; United States / NCI NIH HHS / CA / U01CA81457
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0H43101T0J / irinotecan; 2S9ZZM9Q9V / Bevacizumab; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; XT3Z54Z28A / Camptothecin
  • [Other-IDs] NLM/ PMC2903337
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52. An JH, Lee SY, Jeon JY, Cho KG, Kim SU, Lee MA: Identification of gliotropic factors that induce human stem cell migration to malignant tumor. J Proteome Res; 2009 Jun;8(6):2873-81
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  • [Title] Identification of gliotropic factors that induce human stem cell migration to malignant tumor.
  • Neural stem cells are mobile, are attracted to regions of brain damage, and can migrate a considerable distance to reach a glioma site.
  • This research is expected to provide clues to the molecular mechanisms underlying the migration of neural stem cells (F3 cell) to glioma sites.
  • These results reveal that this novel molecular approach to the monitoring of glioma may provide clinically relevant information regarding tumor malignancy, and should also prove appropriate for high-throughput clinical screening applications.
  • [MeSH-major] Cell Movement. Glioma / genetics. Glioma / metabolism. Neurons / cytology. Stem Cells / physiology
  • [MeSH-minor] Adult. Aged. Annexin A2 / genetics. Annexin A2 / metabolism. Blotting, Western. Cell Line. Electrophoresis, Gel, Two-Dimensional. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Proteomics / methods. Reproducibility of Results. Tumor Cells, Cultured

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  • (PMID = 19351187.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ANXA2 protein, human; 0 / Annexin A2; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins
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53. MacDonald TJ, Arenson EB, Ater J, Sposto R, Bevan HE, Bruner J, Deutsch M, Kurczynski E, Luerssen T, McGuire-Cullen P, O'Brien R, Shah N, Steinbok P, Strain J, Thomson J, Holmes E, Vezina G, Yates A, Phillips P, Packer R: Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933. Cancer; 2005 Dec 15;104(12):2862-71
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  • BACKGROUND: High-grade astrocytomas (HGA) carry a dismal prognosis and compose nearly 20% of all childhood brain tumors.
  • The authors conclude that these commonly used HDCT regimens provide no additional clinical benefit to conventional treatment in HGA, regardless of the amount of measurable residual tumor.
  • [MeSH-minor] Adolescent. Adult. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / radiotherapy. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Humans. Male. Neoplasm Staging. Probability. Prognosis. Prospective Studies. Radiotherapy, High-Energy. Reference Values. Risk Assessment. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiotherapy. Survival Analysis. Time Factors. Treatment Outcome

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16315242.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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54. Jinhu Y, Jianping D, Jun M, Hui S, Yepeng F: Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neurooncol; 2007 May;83(1):47-52
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  • Plain CT scan of the cranium revealed a partly calcified tumor filling the fourth ventricle and its right recess.
  • Cranial MRI showed an inhomogeneously contrast-enhancing tumor and leptomeningeal enhancement encasing the brain stem.
  • Complete resection of the tumor was carried out, and seedings to the floor of the fourth ventricle and cervico-medullary junction were found during the operation.
  • Two months after the first operation, on follow-up MRI of the cranium, the leptomeningeal enhancement encasing the brain stem had resolved spontaneously.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Seeding. Neurosurgical Procedures / adverse effects. Subarachnoid Space. Tomography, X-Ray Computed

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  • (PMID = 17387433.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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55. Gómez-Esteban JC, Berganzo K, Tijero B, Barcena J, Zarranz JJ: Orthostatic hypotension associated with an epidermoid tumor of the IV ventricle. J Neurol; 2009 Aug;256(8):1357-9
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  • [Title] Orthostatic hypotension associated with an epidermoid tumor of the IV ventricle.
  • We report the case of a 32-year-old man with an epidermoid tumor of the fourth ventricle.
  • About 14 years later, he showed a tumor recurrence which was removed.
  • The brain MRI showed a tetraventricular hydrocephalus predominating in the fourth ventricle.
  • [MeSH-minor] Adult. Autonomic Pathways / physiopathology. Baroreflex / physiology. Blood Pressure / physiology. Brain Stem / physiopathology. Fourth Ventricle / pathology. Fourth Ventricle / physiopathology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / complications. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurologic Examination. Neurosurgical Procedures. Treatment Outcome. Ventriculoperitoneal Shunt. Ventriculostomy

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  • (PMID = 19353231.001).
  • [ISSN] 1432-1459
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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56. Tanaka K, Sasayama T, Kawamura A, Kondoh T, Kanomata N, Kohmura E: Isolated oculomotor nerve paresis in anaplastic astrocytoma with exophytic invasion. Neurol Med Chir (Tokyo); 2006 Apr;46(4):198-201
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  • Computed tomography and magnetic resonance imaging showed an intra-axial tumor in the left temporal lobe, extending to the basal and prepontine cisterns, and compressing the brainstem.
  • The tumor was removed subtotally.
  • [MeSH-minor] Adult. Astrocytes / pathology. Biomarkers, Tumor / analysis. Brain Stem / pathology. Cerebral Arteries / pathology. Cisterna Magna / pathology. Dominance, Cerebral / physiology. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness / pathology. Nerve Compression Syndromes / diagnosis. Nerve Compression Syndromes / etiology. Nerve Compression Syndromes / pathology. Nerve Compression Syndromes / surgery. Neuronavigation. Oculomotor Nerve / pathology. Oculomotor Nerve / surgery. Pons / pathology

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  • (PMID = 16636512.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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57. Laigle-Donadey F, Doz F, Delattre JY: Brainstem gliomas in children and adults. Curr Opin Oncol; 2008 Nov;20(6):662-7
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  • [Title] Brainstem gliomas in children and adults.
  • PURPOSE OF REVIEW: The purpose of this review is to determine if recent advances in diagnostic and treatment modalities result in improvement in the pattern of care of brainstem gliomas.
  • RECENT FINDINGS: New MRI techniques may contribute to differential diagnosis and aid neurosurgeons in removing resectable brainstem tumors.
  • However, biopsy remains indicated in many contrast enhancing brainstem masses in adults because of the great variety of differential diagnosis.
  • SUMMARY: Diffuse brainstem glioma is the most common subtype of brainstem tumor and remains a devastating malignancy in children.
  • Given the lack of efficacy of conventional drugs, a better understanding of the biology of this tumor is the key to more targeted therapy.
  • [MeSH-major] Brain Neoplasms / drug therapy. Brain Stem / pathology. Glioma / drug therapy
  • [MeSH-minor] Adult. Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents / therapeutic use. Biopsy. Child. Drug Delivery Systems. Humans. Magnetic Resonance Imaging / methods. Medical Oncology / methods. Neoplasm Metastasis. Neurofibromatosis 1 / drug therapy. Neurofibromatosis 1 / pathology. Signal Transduction

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  • (PMID = 18841048.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents
  • [Number-of-references] 57
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58. Amthauer H, Wurm R, Kuczer D, Ruf J, Michel R, Eisenacher J, Stockhammer F, Denecke T, Felix R, Plotkin M: Relevance of image fusion with MRI for the interpretation of I-123 iodo-methyl-tyrosine scans in patients with suspected recurrent or residual brain tumor. Clin Nucl Med; 2006 Apr;31(4):189-92
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  • [Title] Relevance of image fusion with MRI for the interpretation of I-123 iodo-methyl-tyrosine scans in patients with suspected recurrent or residual brain tumor.
  • PURPOSE: The aim of the study was to investigate the impact of MR/SPECT image fusion on the interpretation of I-123 iodo-methyl-tyrosine (IMT) SPECT examinations in patients with pretreated brain tumors.
  • Tumor localization and extent were evaluated and correlated with histopathology or clinical follow up, including MR imaging.
  • RESULTS: In 10 of 45 (22%) patients, image fusion had a significant impact on the interpretation of scans: 5 suspected SPECT findings were correctly classified as physiological or therapy-related; in another 5 patients, image fusion added relevant clinical information on tumor extent (infiltration of the contralateral hemisphere n = 3, infiltration of the brain stem n = 2).
  • [MeSH-major] Brain Neoplasms / pathology. Iodine Radioisotopes. Magnetic Resonance Imaging. Methyltyrosines. Tomography, Emission-Computed, Single-Photon
  • [MeSH-minor] Adolescent. Adult. Aged. Contrast Media. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual. Retrospective Studies

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  • (PMID = 16550008.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Iodine Radioisotopes; 0 / Methyltyrosines; 14684-02-7 / 3-iodo-alpha-methyltyrosine
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59. Baudin E, Droz JP, Paz-Ares L, van Oosterom AT, Cullell-Young M, Schlumberger M: Phase II study of plitidepsin 3-hour infusion every 2 weeks in patients with unresectable advanced medullary thyroid carcinoma. Am J Clin Oncol; 2010 Feb;33(1):83-8
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  • METHODS: Sixteen patients with MTC and disease progression or large tumor burden received plitidepsin.
  • Tumor response and time-related parameters were evaluated according to Response Evaluation Criteria in Solid Tumors.
  • [MeSH-major] Brain Stem Neoplasms / drug therapy. Depsipeptides / administration & dosage. Thyroid Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Female. Humans. Infusions, Intravenous. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 19704366.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Depsipeptides; Y76ID234HW / aplidine
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60. Bouetel V, Lescanne E, François P, Jan M, Morinière S, Robier A: [Evolution of facial nerve prognosis in vestibular schwannoma surgery by translabyrinthine approach]. Rev Laryngol Otol Rhinol (Bord); 2008;129(1):27-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Evoked Potentials, Auditory, Brain Stem / physiology. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / physiopathology. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Severity of Illness Index

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  • (PMID = 18777766.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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61. Glantz M, Kesari S, Recht L, Fleischhack G, Van Horn A: Understanding the origins of gliomas and developing novel therapies: cerebrospinal fluid and subventricular zone interplay. Semin Oncol; 2009 Aug;36(4 Suppl 2):S17-24
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  • Glioblastoma multiforme (GBM), the most common malignant primary brain tumor in adults, carries a poor prognosis, with median survival generally less than 1 year.
  • Although initial therapy often eradicates the bulk of the tumor, disease recurrence, usually within 2 cm of the original tumor, is almost inevitable.
  • An increasing body of preclinical data suggests that these cells may correspond to stem cells derived from the subventricular zone (SVZ), which migrate to tumor sites and contribute to glioma growth and recurrence.
  • Therapeutic targeting of SVZ stem cell populations via cerebrospinal fluid (CSF)-directed therapy may provide a means for limiting tumor recurrence.
  • This approach has proved successful in the treatment of medulloblastoma, another brain tumor thought to be derived from stem cells.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Brain Neoplasms / drug therapy. Glioblastoma / drug therapy. Neoplasm Recurrence, Local / prevention & control
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant / methods. Humans. Injections, Spinal. Neoplastic Stem Cells. Research Design

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  • (PMID = 19660679.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Boehme V, Zeynalova S, Kloess M, Loeffler M, Kaiser U, Pfreundschuh M, Schmitz N, German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL): Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol; 2007 Jan;18(1):149-57
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  • From 1990 to 1997, 312 patients<or=60 years with an elevated LDH were randomized to five cycles CHOEP+involved field (IF) radiotherapy or three cycles CHOEP followed by high-dose BCNU, etoposide, cytarabine and melphalan (BEAM) and autologous stem-cell transplantation (NHL-A study).

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  • (PMID = 17018708.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VB0R961HZT / Prednisone
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63. Zhang M, Segerer F, Ketonen L, Mahajan A, Wolff J: Prediction of tumour regrowth of pontine glioma using a two-term model. Anticancer Res; 2008 Mar-Apr;28(2A):741-9
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  • [MeSH-major] Brain Stem Neoplasms / pathology. Glioma / pathology. Models, Biological
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Neoplasm Recurrence, Local. Survival Analysis. Time Factors

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  • (PMID = 18507015.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Greece
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64. Tamura K, Aoyagi M, Wakimoto H, Ando N, Nariai T, Yamamoto M, Ohno K: Accumulation of CD133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation. J Neurosurg; 2010 Aug;113(2):310-8
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  • OBJECT: Recent evidence suggests that a glioma stem cell subpopulation might contribute to radioresistance in malignant gliomas.
  • Histological sections were subjected to immunohistochemistry for MIB-1, factor VIII, and stem cell markers, nestin and CD133.
  • Histopathological examination after GKS and EBRT showed variable mixtures of viable tumor tissues and necrosis.
  • Viable tumor tissues exhibited high MIB-1 indices but reduced numbers of tumor blood vessels.
  • CONCLUSIONS: The results indicate that CD133-positive glioma stemlike cells can survive high-dose irradiation, leading to recurrence, despite prolonged damage to tumor blood vessels.
  • [MeSH-major] Antigens, CD / metabolism. Brain Neoplasms / radiotherapy. Brain Neoplasms / surgery. Glioblastoma / radiotherapy. Glioblastoma / surgery. Glycoproteins / metabolism. Peptides / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers / metabolism. Biopsy. Blood Vessels / radiation effects. Combined Modality Therapy. Disease Progression. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Positron-Emission Tomography. Radiation Tolerance. Radiosurgery. Radiotherapy. Young Adult

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  • (PMID = 20205512.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Biomarkers; 0 / Glycoproteins; 0 / Peptides
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65. Newlin HE, Morris CG, Amdur RJ, Mendenhall WM: Neurotropic melanoma of the head and neck with clinical perineural invasion. Am J Clin Oncol; 2005 Aug;28(4):399-402
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  • OBJECTIVE: The purpose of this article is to report our experience with neurotropic melanoma, a rare malignancy that sometimes produces neurologic symptoms because of a direct extension of the primary tumor.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Head and Neck Neoplasms / pathology. Melanoma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Peripheral Nervous System Neoplasms / radiotherapy. Peripheral Nervous System Neoplasms / surgery. Radiotherapy, Adjuvant. Salvage Therapy

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  • (PMID = 16062083.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Ehtesham M, Sarangi A, Valadez JG, Chanthaphaychith S, Becher MW, Abel TW, Thompson RC, Cooper MK: Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells. Oncogene; 2007 Aug 23;26(39):5752-61
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  • We have investigated the activity of this pathway in adult gliomas, and demonstrate that the Hh pathway is operational and activated within grade II and III gliomas, but not grade IV de novo glioblastoma multiforme.
  • These findings suggest a regulatory role for the Hh pathway in progenitor cells within grade II and III gliomas, and the potential clinical utility of monitoring and targeting this pathway in these primary brain tumors.
  • [MeSH-major] Brain Neoplasms / genetics. Gene Expression Regulation, Neoplastic. Glioma / genetics. Hedgehog Proteins / genetics. Neoplastic Stem Cells / physiology. Signal Transduction
  • [MeSH-minor] Animals. Blotting, Western. Humans. Ligands. Mice. Neoplasm Staging. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Receptors, Cell Surface / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors / physiology. Tumor Cells, Cultured

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  • (PMID = 17353902.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS02133; United States / NINDS NIH HHS / NS / R01 NS051557
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Ligands; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptors, Cell Surface; 0 / SHH protein, human; 0 / Transcription Factors; 0 / patched receptors
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67. Tuettenberg J, Grobholz R, Seiz M, Brockmann MA, Lohr F, Wenz F, Vajkoczy P: Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy. J Cancer Res Clin Oncol; 2009 Sep;135(9):1239-44
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  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Glioblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Survival Rate

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  • (PMID = 19277712.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors
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68. Soussain C, Hoang-Xuan K, Taillandier L, Fourme E, Choquet S, Witz F, Casasnovas O, Dupriez B, Souleau B, Taksin AL, Gisselbrecht C, Jaccard A, Omuro A, Sanson M, Janvier M, Kolb B, Zini JM, Leblond V, Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire: Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire. J Clin Oncol; 2008 May 20;26(15):2512-8
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  • [Title] Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire.
  • We report the results of a prospective multicenter trial of intensive chemotherapy followed by autologous hematopoietic stem-cell rescue (IC + HCR) in immunocompetent adult patients with PCNSL or intraocular lymphoma (IOL) after failure of high-dose methotrexate-based treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / therapy. Eye Neoplasms / therapy. Hematopoietic Stem Cell Transplantation. Lymphoma, Large B-Cell, Diffuse / therapy. Neoplasm Recurrence, Local / therapy. Salvage Therapy
  • [MeSH-minor] Adult. Aged. Busulfan / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Cytarabine / administration & dosage. Etoposide / administration & dosage. Female. Humans. Male. Middle Aged. Prospective Studies. Survival Rate. Thiotepa / administration & dosage

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  • (PMID = 18413641.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; 905Z5W3GKH / Thiotepa; G1LN9045DK / Busulfan
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69. Duntsch C, Zhou Q, Weimar JD, Frankel B, Robertson JH, Pourmotabbed T: Up-regulation of neuropoiesis generating glial progenitors that infiltrate rat intracranial glioma. J Neurooncol; 2005 Feb;71(3):245-55
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  • To investigate adult neural stem cell (NSC) biology in relation to glioma, the C6 glioma cell line was tagged with green fluorescent protein (GFP) and inoculated into the brain of adult rats.
  • The in vivo biological response of the brain to glioma was studied using immunohistochemical analysis of the subventricular zone (SVZ), peritumoral areas, and glioma.
  • Nestin immunoreactive cells were found infiltrating glioma, but the distribution of abnormal immunoreactivity was restricted to the dorsal and medial border of the tumor relative to the ipsilateral ventricle.
  • Furthermore, a dense contiguous population of nestin immunoreactive cells could be found streaming from ipsilateral dorsal tip of the SVZ, tracking along the ventral margin of the corpus callosum, and fanning out to encompass and infiltrate the proximal tumor border.
  • Although most cells were either nestin or glial fibrillary acidic protein (GFAP) immunoreactive in the SVZ and along the ventral margin of the corpus callosum, the number of cells co-expressing both markers increased proportionally as the tumor was approached so that the predominant cell population along the proximal tumor border was GFAP immunoreactive.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Glioma / metabolism. Glioma / pathology. Neuroglia / metabolism. Neuroglia / pathology. Stem Cells / metabolism
  • [MeSH-minor] Animals. Cell Differentiation. Cell Lineage. Cell Movement. Cerebral Ventricles / pathology. Disease Models, Animal. Fluorescent Antibody Technique. Glial Fibrillary Acidic Protein / metabolism. Immunohistochemistry. Intermediate Filament Proteins / metabolism. Neoplasm Transplantation. Nerve Tissue Proteins / metabolism. Nestin. Rats. Rats, Inbred WF. Rats, Sprague-Dawley. Up-Regulation

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  • (PMID = 15735912.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, rat; 0 / Nestin
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70. Kroonen J, Nguyen-Khac MT, Deprez M, Rogister B, Robe P: [Glioblastoma, an example of translational research?]. Rev Med Liege; 2008 May-Jun;63(5-6):251-6
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  • In the adult, GBM is the most frequent and most aggressive tumour of the Central Nervous System.
  • GBM stem cells have been recently described and it was demonstrated that they are specifically implied in the experimental tumorigenesis.
  • It is thus very attractive to speculate on a possible relationship between these GBM stem cells and the neural stem cells which are persisting in the neurogenic zones of the adult brain.
  • In this review, we formulate and discuss the hypothesis by which, in a patient with GBM, malignant stem cells might be present in the neurogenic zones, away from the tumour mass.
  • [MeSH-major] Brain Neoplasms / pathology. Glioblastoma / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Biomedical Research. Humans. Neoplastic Stem Cells

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  • (PMID = 18669189.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Belgium
  • [Number-of-references] 27
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71. Fukaya R, Yoshida K, Ohira T, Kawase T: Trigeminal schwannomas: experience with 57 cases and a review of the literature. Neurosurg Rev; 2010 Apr;34(2):159-71
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  • Trigeminal schwannoma is a mostly benign tumor that can be cured by complete resection.
  • Since 1990, all such patients have been treated using three main types of middle fossa skull base approaches, which minimize the exposure of the brain: the anterior transpetrosal approach, subtemporal interdural approach (Dolenc), or a combination of these approaches.
  • Before 1990, total tumor removal was achieved in only three of eight patients (38%).
  • However, total surgical removal after surgery and Gamma knife surgery was very difficult because of dense adhesions to the brain stem and cranial nerves.
  • A correct anatomical knowledge is critical for minimizing brain exposure and avoiding surgical complications.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cranial Fossa, Middle / surgery. Dura Mater / surgery. Female. Follow-Up Studies. Humans. Karnofsky Performance Status. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Radiosurgery. Retrospective Studies. Skull Base / surgery. Temporal Bone / surgery. Treatment Outcome. Young Adult

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  • (PMID = 20963463.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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72. Li DR, Ishikawa T, Zhao D, Michiue T, Quan L, Zhu BL, Maeda H: Unexpected sudden death due to intracranial chordoma: an autopsy case. Forensic Sci Int; 2010 Jul 15;200(1-3):e15-8
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  • We report an autopsy case of a sudden unexpected death due to clinically undiagnosed intracranial chordoma in the brainstem without haemorrhage.
  • The autopsy revealed two small gelatinous and semi-translucent greyish tumours on the ventral surface of the brainstem between the midbrain and pons.
  • The brain was markedly swollen, with enlarged lateral and third ventricles, but the aqueduct was compressed and narrowed.
  • The cause of death was diagnosed as acute obstructive hydrocephalus due to a ventral brainstem tumour.
  • The brainstem is one of the most vulnerable regions in the brain, and careful examination of this region is important for forensic pathologists.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Chordoma / pathology. Death, Sudden / etiology
  • [MeSH-minor] Adult. Brain / pathology. Forensic Pathology. Humans. Hydrocephalus / etiology. Male. Neoplasm Invasiveness

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  • [Copyright] (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20444561.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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73. Okada H, Low KL, Kohanbash G, McDonald HA, Hamilton RL, Pollack IF: Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. J Neurooncol; 2008 Jul;88(3):245-50
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  • [Title] Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas.
  • We investigated the protein expression of three glioma-associated antigens (GAAs) in pediatric brain stem glioma (BSG) and non-brain stem glioma (NBSG) cases with a view to their possible use in immunotherapy.
  • Thirteen of 15 BSGs and all 12 NBSGs expressed at least one of GAAs; and 7 BSGs and 9 NBSGs expressed at least two of these GAAs at higher levels than non-neoplastic brain.
  • There was no association between the tumor grade and levels of GAA expression.

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  • (PMID = 18324354.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS 40923; United States / NINDS NIH HHS / NS / NS040923-06A15462; United States / NINDS NIH HHS / NS / P01 NS040923; United States / NCI NIH HHS / CA / P01 CA 100327; United States / NCI NIH HHS / CA / P01 CA100327; United States / NINDS NIH HHS / NS / P01 NS040923-06A15462
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Interleukin-13 Receptor alpha2 Subunit; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 2.7.10.1 / Receptor, EphA2
  • [Other-IDs] NLM/ NIHMS70086; NLM/ PMC2561297
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74. Nohroudi K, Arnhold S, Berhorn T, Addicks K, Hoehn M, Himmelreich U: In vivo MRI stem cell tracking requires balancing of detection limit and cell viability. Cell Transplant; 2010;19(4):431-41
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  • [Title] In vivo MRI stem cell tracking requires balancing of detection limit and cell viability.
  • Cell-based therapy using adult mesenchymal stem cells (MSCs) has already been the subject of clinical trials, but for further development and optimization the distribution and integration of the engrafted cells into host tissues have to be monitored.
  • [MeSH-major] Cell Movement. Contrast Media / analysis. Ferric Compounds / analysis. Magnetic Resonance Imaging. Mesenchymal Stem Cell Transplantation. Metal Nanoparticles / analysis
  • [MeSH-minor] Animals. Bone Marrow Cells / cytology. Brain Neoplasms / therapy. Cell Survival. Glioma / therapy. Male. Neoplasm Transplantation. Rats. Rats, Wistar

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  • (PMID = 20149297.001).
  • [ISSN] 1555-3892
  • [Journal-full-title] Cell transplantation
  • [ISO-abbreviation] Cell Transplant
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
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75. Majchrzak H, Krawczyk L, Majchrzak K, Bierzyńska-Macyszyn G: [Surgical treatment of brainstem gliomas and other tumors in adults]. Neurol Neurochir Pol; 2005 Jan-Feb;39(1):27-32
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  • [Title] [Surgical treatment of brainstem gliomas and other tumors in adults].
  • BACKGROUND AND PURPOSE: After the introduction of MR imaging to the diagnostics of brainstem tumors and after the introduction of microsurgical procedures to their treatment, the successful treatment, particularly of focal and exophytic forms of these tumors has begun all over the world.
  • The objective of this paper is to establish indications for surgical treatment of gliomas and other tumors of brainstem, to determine surgical approaches and to establish the outcome.
  • MATERIAL AND METHODS: Within the last 6 years, 12 patients with focal and exophytic tumors of the brainstem in adults were operated on.
  • CONCLUSIONS: Patients with focal and exophytic forms of the brainstem tumors in MR imaging are qualified for surgical treatment.
  • Immediate results of the treatment depend on the localization and size of the neoplasm.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Glioma / surgery. Neurosurgical Procedures
  • [MeSH-minor] Adult. Brain Neoplasms / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Postoperative Complications / prevention & control. Retrospective Studies. Time Factors

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  • (PMID = 15735987.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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76. Abe M, Tokumaru S, Tabuchi K, Kida Y, Takagi M, Imamura J: Stereotactic radiation therapy with chemotherapy in the management of recurrent medulloblastomas. Pediatr Neurosurg; 2006;42(2):81-8
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  • Five patients were treated with one to two sequential courses of high-dose chemotherapy with peripheral blood stem cell transplantation.
  • The reduction in tumor size after SRT was often remarkable.
  • In contrast, all 8 patients with metastasis had new lesions either in the spinal canal or on the surface of the brain outside the target area of SRT.
  • One patient had brainstem edema after SRT causing bulbar palsy and quadriparesis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / therapy. Medulloblastoma / therapy. Neoplasm Recurrence, Local / therapy. Radiosurgery / methods
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Cisplatin / administration & dosage. Dose-Response Relationship, Drug. Etoposide / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Male. Peripheral Blood Stem Cell Transplantation. Radiotherapy Dosage. Retrospective Studies

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16465076.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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77. Foreman NK, Schissel D, Le T, Strain J, Fleitz J, Quinones R, Giller R: A study of sequential high dose cyclophosphamide and high dose carboplatin with peripheral stem-cell rescue in resistant or recurrent pediatric brain tumors. J Neurooncol; 2005 Jan;71(2):181-7
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  • [Title] A study of sequential high dose cyclophosphamide and high dose carboplatin with peripheral stem-cell rescue in resistant or recurrent pediatric brain tumors.
  • PURPOSE: To determine the maximum tolerated dose (MTD) of carboplatin with autologous hematopoietic stem-cell rescue, in children with poor-prognosis brain tumors.
  • PATIENTS AND METHODS: A previously determined dose of cyclophosphamide with stem-cell rescue was used as a first course.
  • In a second course, carboplatin was given for 3 days with stem-cell rescue to 20 children.
  • Toxicity and tumor response were recorded.
  • The median duration of tumor response was 10 months (range: 1.5-87 months) with two children disease free at 66 and 87 months.
  • CONCLUSION: The MTD of carboplatin with stem-cell rescue is 700 mg/m2/day for 3 days.
  • Sequential stem-cell supported cyclophosphamide and carboplatin was tolerable in children with brain tumors and produced responses in PNETs and Germinomas.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / therapy. Drug Resistance, Neoplasm. Hematopoietic Stem Cell Transplantation. Neoplasm Recurrence, Local / therapy. Salvage Therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Carboplatin / administration & dosage. Carboplatin / therapeutic use. Child. Child, Preschool. Cyclophosphamide / administration & dosage. Cyclophosphamide / therapeutic use. Dose-Response Relationship, Drug. Female. Humans. Male

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  • (PMID = 15690136.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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78. Fang DD, Kim YJ, Lee CN, Aggarwal S, McKinnon K, Mesmer D, Norton J, Birse CE, He T, Ruben SM, Moore PA: Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery. Br J Cancer; 2010 Apr 13;102(8):1265-75
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  • [Title] Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery.
  • BACKGROUND: Despite earlier studies demonstrating in vitro propagation of solid tumour cancer stem cells (CSCs) as non-adherent tumour spheres, it remains controversial as to whether CSCs can be maintained in vitro.
  • [MeSH-major] Antigens, CD / metabolism. Colonic Neoplasms / pathology. Glycoproteins / metabolism. Neoplastic Stem Cells. Peptides / metabolism. Spheroids, Cellular. Tumor Cells, Cultured
  • [MeSH-minor] AC133 Antigen. ATP Binding Cassette Transporter, Sub-Family G, Member 2. ATP-Binding Cassette Transporters / genetics. Adult. Aged. Aged, 80 and over. Animals. Cell Differentiation. Drug Resistance, Neoplasm. Female. Humans. Male. Mass Spectrometry. Membrane Proteins / analysis. Mice. Mice, Nude. Mice, SCID. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Transplantation. Proteomics

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  • (PMID = 20332776.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / AC133 Antigen; 0 / ATP Binding Cassette Transporter, Sub-Family G, Member 2; 0 / ATP-Binding Cassette Transporters; 0 / Antigens, CD; 0 / Glycoproteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / PROM1 protein, human; 0 / Peptides; 0 / Prom1 protein, mouse
  • [Other-IDs] NLM/ PMC2855999
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79. Hoei-Hansen CE, Sehested A, Juhler M, Lau YF, Skakkebaek NE, Laursen H, Rajpert-de Meyts E: New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J Pathol; 2006 May;209(1):25-33
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  • We applied recent knowledge from gonadal germ cell tumours and analysed expression of a wide panel of stem cell-related proteins (C-KIT, OCT-3/4 (POU5F1), AP-2gamma (TFAP2C), and NANOG) and developmentally regulated germ cell-specific proteins (including MAGE-A4, NY-ESO-1, and TSPY).
  • Stem cell related proteins were highly expressed in intracranial germ cell tumours, and many similarities were detected with their gonadal equivalents, including a close similarity with primordial germ cells.
  • The expression of genes associated with embryonic stem cell pluripotency in CNS germ cell tumours strongly suggests that these tumours are derived from cells that retain, at least partially, an embryonic stem cell-like phenotype, which is a hallmark of primordial germ cells.
  • [MeSH-major] Brain Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Neoplastic Stem Cells / pathology. Pluripotent Stem Cells / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Differentiation / metabolism. Cell Differentiation. Child. Child, Preschool. Embryonal Carcinoma Stem Cells. Female. Gene Expression. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Infant. Infant, Newborn. Male. Neoplasm Proteins / metabolism. Stromal Cells / metabolism. Transcription Factors / metabolism

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  • [Copyright] Copyright 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 16456896.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Neoplasm Proteins; 0 / Transcription Factors
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80. Lotze C, Schüler F, Krüger WH, Hirt C, Kirsch M, Vogelgesang S, Schmidt CA, Dölken G: Combined immunoradiotherapy induces long-term remission of CNS relapse of peripheral, diffuse, large-cell lymphoma after allogeneic stem cell transplantation: case study. Neuro Oncol; 2005 Oct;7(4):508-10
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  • [Title] Combined immunoradiotherapy induces long-term remission of CNS relapse of peripheral, diffuse, large-cell lymphoma after allogeneic stem cell transplantation: case study.
  • Graft-versus-leukemia effects (GvL) contribute substantially to eradication of hematological malignancies after allogeneic stem cell transplantation.
  • Few data are available describing GvL activity within the brain.
  • The brain was irradiated with 44 Gy, anti-CD20 antibodies were given, and the immunosuppression was withdrawn.
  • [MeSH-major] Antibodies / therapeutic use. Brain Neoplasms / radiotherapy. Graft vs Leukemia Effect / physiology. Lymphoma, Large B-Cell, Diffuse / radiotherapy. Stem Cell Transplantation
  • [MeSH-minor] Adult. Antigens, CD20 / immunology. Humans. Male. Neoplasm Recurrence, Local / immunology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy

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81. Meregalli M, Farini A, Belicchi M, Torrente Y: CD133(+) cells isolated from various sources and their role in future clinical perspectives. Expert Opin Biol Ther; 2010 Nov;10(11):1521-8
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  • Initially, the expression of CD133 antigen was seen only in the hematopoietic derived CD34(+) stem cells.
  • CD133(+) neurosphere cells isolated from brain are able to differentiate into both neurons and glial cells.
  • These data suggested that CD133 could be a specific marker for various stem and progenitor cell populations.
  • OBJECTIVES: The main goal would be to describe the role for CD133 as a marker of stem cells able to engraft and differentiate, to form functional non-hematopoietic adult lineages and contribute to disease amelioration via tissue regeneration.
  • RESULTS/CONCLUSION: In conclusion, since the rise of CD133 antigen as a suitable stem cell marker, the possible use of CD133(+) stem cells in therapeutic applications has opened a new promising field in the treatment of degenerating diseases.
  • The human circulating cells expressing the CD133 antigen behave as a stem cell population capable of commitment to hematopoietic, endothelial and myogenic lineages.
  • [MeSH-major] Antigens, CD / analysis. Glycoproteins / analysis. Peptides / analysis. Stem Cell Transplantation. Stem Cells / chemistry
  • [MeSH-minor] Animals. Cell Differentiation. Cell Lineage. Clinical Trials as Topic. Epithelial Cells / chemistry. Hematopoietic Stem Cells / chemistry. Humans. Ischemia / surgery. Mice. Mice, Inbred NOD. Mice, SCID. Muscular Dystrophies / surgery. Neoplasm Transplantation. Neoplasms / surgery. Neoplastic Stem Cells / chemistry. Organ Specificity. Transplantation, Heterologous

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  • (PMID = 20932225.001).
  • [ISSN] 1744-7682
  • [Journal-full-title] Expert opinion on biological therapy
  • [ISO-abbreviation] Expert Opin Biol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Glycoproteins; 0 / Peptides
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82. Maderna E, Salmaggi A, Calatozzolo C, Limido L, Pollo B: Nestin, PDGFRbeta, CXCL12 and VEGF in glioma patients: different profiles of (pro-angiogenic) molecule expression are related with tumor grade and may provide prognostic information. Cancer Biol Ther; 2007 Jul;6(7):1018-24
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  • [Title] Nestin, PDGFRbeta, CXCL12 and VEGF in glioma patients: different profiles of (pro-angiogenic) molecule expression are related with tumor grade and may provide prognostic information.
  • Nestin, a marker for multipotential neuroepithelial stem cells, is detected in neuroepithelial tumors and in proliferating endothelial cells (ECs) and is involved in the early stages of lineage commitment, proliferation and differentiation.
  • We performed a retrospective study on the presence and role of nestin-expressing cells in 102 patients with glioma, relating the findings to VEGF, CXCL12, PDGFRbeta expression and to clinical outcome (time to tumor progression-TTP and survival time-ST).
  • [MeSH-major] Brain Neoplasms / chemistry. Chemokine CXCL12 / analysis. Glioma / blood supply. Intermediate Filament Proteins / analysis. Nerve Tissue Proteins / analysis. Receptor, Platelet-Derived Growth Factor beta / analysis. Vascular Endothelial Growth Factor A / analysis
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Nestin. Prognosis

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  • (PMID = 17611402.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CXCL12 protein, human; 0 / Chemokine CXCL12; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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83. Lin T, Islam O, Heese K: ABC transporters, neural stem cells and neurogenesis--a different perspective. Cell Res; 2006 Nov;16(11):857-71
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  • [Title] ABC transporters, neural stem cells and neurogenesis--a different perspective.
  • Stem cells intrigue.
  • They have the ability to divide exponentially, recreate the stem cell compartment, as well as create differentiated cells to generate tissues.
  • Stem cells have the capacity to generate specific tissues or even whole organs like the blood, heart, or bones.
  • A subgroup of stem cells, the neural stem cells (NSCs), is characterized as a self-renewing population that generates neurons and glia of the developing brain.
  • They can be isolated, genetically manipulated and differentiated in vitro and reintroduced into a developing, adult or a pathologically altered central nervous system.
  • Characterization of genes with tightly controlled expression patterns during differentiation represents an approach to understanding the regulation of stem cell commitment.
  • The regulation of stem cell biology by the ATP-binding cassette (ABC) transporters has emerged as an important new field of investigation.
  • As a major focus of stem cell research is in the manipulation of cells to enable differentiation into a targeted cell population; in this review, we discuss recent literatures on ABC transporters and stem cells, and propose an integrated view on the role of the ABC transporters, especially ABCA2, ABCA3, ABCB1 and ABCG2, in NSCs' proliferation, differentiation and regulation, along with comparisons to that in hematopoietic and other stem cells.
  • [MeSH-major] ATP-Binding Cassette Transporters / metabolism. Neurons / cytology. Stem Cells / cytology
  • [MeSH-minor] ATP Binding Cassette Transporter, Sub-Family B. ATP Binding Cassette Transporter, Sub-Family G, Member 2. ATP-Binding Cassette, Sub-Family B, Member 1. Animals. Cell Differentiation / genetics. Cell Differentiation / physiology. Cell Proliferation. Gene Expression / genetics. Humans. Models, Biological. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Neoplasm Proteins / physiology. Organic Anion Transporters / genetics. Organic Anion Transporters / metabolism. Organic Anion Transporters / physiology

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  • (PMID = 17088897.001).
  • [ISSN] 1748-7838
  • [Journal-full-title] Cell research
  • [ISO-abbreviation] Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ABCB1 protein, human; 0 / ABCG2 protein, human; 0 / ATP Binding Cassette Transporter, Sub-Family B; 0 / ATP Binding Cassette Transporter, Sub-Family G, Member 2; 0 / ATP-Binding Cassette Transporters; 0 / ATP-Binding Cassette, Sub-Family B, Member 1; 0 / Neoplasm Proteins; 0 / Organic Anion Transporters
  • [Number-of-references] 181
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84. Schild AM, Fricke J, Herkenrath P, Bolz H, Neugebauer A: [Neuro-ophthalmological and ophthalmological findings in Joubert syndrome]. Klin Monbl Augenheilkd; 2010 Oct;227(10):786-91
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  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adolescent. Amblyopia / diagnosis. Amblyopia / genetics. Antigens, Neoplasm / genetics. Blepharoptosis / diagnosis. Blepharoptosis / genetics. Brain Stem / abnormalities. Brain Stem / pathology. Cerebellum / abnormalities. Cerebellum / pathology. Child. Child, Preschool. Consanguinity. DNA Mutational Analysis. Electroretinography. Facial Paralysis / diagnosis. Facial Paralysis / genetics. Female. Fundus Oculi. Humans. Magnetic Resonance Imaging. Male. Membrane Proteins / genetics. Neoplasm Proteins / genetics. Nystagmus, Optokinetic / genetics. Ocular Motility Disorders / diagnosis. Ocular Motility Disorders / genetics. Refraction, Ocular. Retrospective Studies. Strabismus / diagnosis. Strabismus / genetics. Visual Acuity. Young Adult

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20963681.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antigens, Neoplasm; 0 / Cep290 protein, human; 0 / Membrane Proteins; 0 / NPHP1 protein, human; 0 / Neoplasm Proteins; Arima syndrome
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85. Charpiot A, Tringali S, Zaouche S, Ferber-Viart C, Dubreuil C: Perioperative complications after translabyrinthine removal of large or giant vestibular schwannoma: Outcomes for 123 patients. Acta Otolaryngol; 2010 Nov;130(11):1249-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Aphasia / etiology. Brain Stem / pathology. Cerebrospinal Fluid Leak. Cerebrospinal Fluid Rhinorrhea / etiology. Edema / etiology. Electromyography. Epilepsy / etiology. Facial Nerve / physiopathology. Female. Follow-Up Studies. Hematoma, Subdural / etiology. Hematoma, Subdural / surgery. Humans. Magnetic Resonance Imaging. Male. Meningitis / etiology. Middle Aged. Neoplasm Staging. Nervous System Diseases / etiology. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [CommentIn] Acta Otolaryngol. 2011 Nov;131(11):1237-8 [21728749.001]
  • (PMID = 20443757.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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86. Murat A, Migliavacca E, Gorlia T, Lambiv WL, Shay T, Hamou MF, de Tribolet N, Regli L, Wick W, Kouwenhoven MC, Hainfellner JA, Heppner FL, Dietrich PY, Zimmer Y, Cairncross JG, Janzer RC, Domany E, Delorenzi M, Stupp R, Hegi ME: Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol; 2008 Jun 20;26(18):3015-24
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  • [Title] Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.
  • PURPOSE: Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently, to the particular biologic behavior of tumor stem-like cells.
  • Better outcome was associated with gene clusters characterizing features of tumor-host interaction including tumor vascularization and cell adhesion, and innate immune response.
  • CONCLUSION: This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma.
  • [MeSH-major] Adult Stem Cells / pathology. Brain Neoplasms / pathology. Brain Neoplasms / therapy. Glioblastoma / pathology. Glioblastoma / therapy. Receptor, Epidermal Growth Factor / biosynthesis
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents, Alkylating / therapeutic use. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Drug Resistance, Neoplasm. Gene Expression Profiling. Genes, Homeobox. Humans. Middle Aged. Multigene Family. Radiation Tolerance

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  • (PMID = 18565887.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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87. Suzuki Y, Tanaka K, Negishi D, Shimizu M, Yoshida Y, Hashimoto T, Yamazaki H: Pharmacokinetic investigation of increased efficacy against malignant gliomas of carboplatin combined with hyperbaric oxygenation. Neurol Med Chir (Tokyo); 2009 May;49(5):193-7; discussion 197
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  • The efficacy of intravenous administration of 400 mg carboplatin/m(2) body surface area over 60 minutes combined with hyperbaric oxygenation (HBO) therapy (0.2 MPa for 60 min) was investigated in 6 Japanese patients (aged 36-67 years) with malignant or brainstem gliomas.
  • Brain tumor response was evaluated by magnetic resonance imaging as a function of maximum plasma concentration, area under the curve, or mean residence time (MRT) for carboplatin.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Brain Neoplasms / therapy. Carboplatin / therapeutic use. Glioblastoma / therapy. Hyperbaric Oxygenation
  • [MeSH-minor] Adult. Aged. Astrocytoma / drug therapy. Astrocytoma / radiotherapy. Astrocytoma / surgery. Astrocytoma / therapy. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / radiotherapy. Brain Stem Neoplasms / surgery. Brain Stem Neoplasms / therapy. Chromatography, High Pressure Liquid. Combined Modality Therapy. Cranial Irradiation. Drug Synergism. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / therapy. Salvage Therapy. Treatment Outcome

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  • (PMID = 19465788.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; BG3F62OND5 / Carboplatin
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88. Mimeault M, Batra SK: Targeting of cancer stem/progenitor cells plus stem cell-based therapies: the ultimate hope for treating and curing aggressive and recurrent cancers. Panminerva Med; 2008 Mar;50(1):3-18
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  • [Title] Targeting of cancer stem/progenitor cells plus stem cell-based therapies: the ultimate hope for treating and curing aggressive and recurrent cancers.
  • The late-stage leukemias and disseminated and metastatic sarcomas, melanomas, brain tumors and epithelial cancers are the devastating diseases associated with a high rate of recurrence after treatment with the conventional clinical therapies including surgery, ionizing radiation, hormonal therapy and systemic chemotherapy, which generally lead to the death of patients.
  • Recent advances have led to the identification of specific oncogenic products that are implicated in the malignant transformation of adult stem/progenitor cells into leukemic or tumorigenic and migrating cancer stem/progenitor cells during cancer progression.
  • Of therapeutic interest, the molecular targeting of deregulated signaling elements in cancer stem/progenitor cells and their local microenvironment represents a new potential strategy for the development of more effective clinical treatments against aggressive cancers.
  • Particularly, the combined use of chemotherapeutic drugs to eradicate cancer-initiating cells with hematopoietic stem cell or genetically-modified stem cell transplant is emerging as potential cancer treatments that hold great promise in the area of clinical cancer research.
  • These targeting and stem cell-based therapies may offer the ultimate hope for treating and even curing the patients diagnosed with locally advanced cancers at high risk of recurrence, metastatic and/or relapsed cancers in the clinics.

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