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1. Figols-Ladrón de Guevara J, Lafuente-Sánchez JV: [The medulloblastoma]. Rev Neurol; 2006 Aug 16-31;43(4):213-7
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The medulloblastoma].
  • INTRODUCTION AND DEVELOPMENT: Medulloblastoma is a cerebellar small cell tumor, whose ancestor cell has not been yet identified in the human normal embriology: its exact origin is, in fact, still unknown.
  • [MeSH-major] Brain Neoplasms. Medulloblastoma
  • [MeSH-minor] Adult. Cerebellum / pathology. Chromosomes, Human, Pair 17. Diagnosis, Differential. Humans. Isochromosomes. Prognosis. Survival Rate

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  • (PMID = 16883510.001).
  • [ISSN] 0210-0010
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Spain
  • [Number-of-references] 17
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2. Secondino S, Citterio A, Pedrazzoli P, Funaioli C, Scialfa GG, Siena S: Neuroimaging abnormalities in adult medulloblastoma undergoing intensified therapy. Anticancer Res; 2008 Nov-Dec;28(6B):3991-2
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  • [Title] Neuroimaging abnormalities in adult medulloblastoma undergoing intensified therapy.
  • We report on radiological abnormalities resembling recurrent tumor in adult medulloblastoma receiving intensified chemotherapy and radiotherapy.
  • Evidence provided in this paper confirms previous reports in the pediatric population and suggests that neuroradiologist and medical oncologists should be aware of new possible radiological findings related to aggressive treatments for brain tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Medulloblastoma / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 19192661.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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3. Ferretti E, De Smaele E, Po A, Di Marcotullio L, Tosi E, Espinola MS, Di Rocco C, Riccardi R, Giangaspero F, Farcomeni A, Nofroni I, Laneve P, Gioia U, Caffarelli E, Bozzoni I, Screpanti I, Gulino A: MicroRNA profiling in human medulloblastoma. Int J Cancer; 2009 Feb 01;124(3):568-77
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  • [Title] MicroRNA profiling in human medulloblastoma.
  • Medulloblastoma is an aggressive brain malignancy with high incidence in childhood.
  • A high throughput microRNA expression profiles was performed in human primary medulloblastoma specimens to investigate microRNA involvement in medulloblastoma carcinogenesis.
  • We identified specific microRNA expression patterns which distinguish medulloblastoma differing in histotypes (anaplastic, classic and desmoplastic), in molecular features (ErbB2 or c-Myc overexpressing tumors) and in disease-risk stratification.
  • MicroRNAs expression profile clearly differentiates medulloblastoma from either adult or fetal normal cerebellar tissues.
  • This property has been addressed for miR-9 and miR-125a, whose rescued expression promoted medulloblastoma cell growth arrest and apoptosis while targeting the proproliferative truncated TrkC isoform.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cerebellar Neoplasms / genetics. Gene Expression Profiling. Medulloblastoma / genetics. MicroRNAs

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  • [Copyright] Copyright (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18973228.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP07118
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MicroRNAs; EC 2.7.10.1 / Receptor, trkC
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4. Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ: Subtypes of medulloblastoma have distinct developmental origins. Nature; 2010 Dec 23;468(7327):1095-9
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  • [Title] Subtypes of medulloblastoma have distinct developmental origins.
  • Medulloblastoma encompasses a collection of clinically and molecularly diverse tumour subtypes that together comprise the most common malignant childhood brain tumour.
  • The pathological processes that drive heterogeneity among the other medulloblastoma subtypes are not known, hindering the development of much needed new therapies.
  • Here we provide evidence that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem.
  • These lesions persisted in all mutant adult mice; moreover, in 15% of cases in which Tp53 was concurrently deleted, they progressed to form medulloblastomas that recapitulated the anatomy and gene expression profiles of human WNT-subtype medulloblastoma.
  • We provide the first evidence, to our knowledge, that subtypes of medulloblastoma have distinct cellular origins.

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  • [Cites] N Engl J Med. 2009 Sep 17;361(12):1173-8 [19726761.001]
  • [Cites] Curr Opin Cell Biol. 2009 Dec;21(6):741-7 [19883998.001]
  • [Cites] Proc Natl Acad Sci U S A. 2010 May 4;107(18):8422-7 [20400693.001]
  • [Cites] Nature. 2010 Jul 29;466(7306):632-6 [20639864.001]
  • [Cites] EMBO J. 1999 Nov 1;18(21):5931-42 [10545105.001]
  • [Cites] Cancer Res. 2001 Jan 15;61(2):513-6 [11212243.001]
  • [Cites] Hum Mol Genet. 2001 Jun 1;10(12):1325-34 [11406614.001]
  • [Cites] Nat Genet. 2001 Dec;29(4):418-25 [11694875.001]
  • [Cites] Science. 2002 Jul 19;297(5580):365-9 [12130776.001]
  • [Cites] Cancer Res. 2003 Sep 1;63(17):5428-37 [14500378.001]
  • [Cites] Cancer Cell. 2004 Sep;6(3):229-40 [15380514.001]
  • [Cites] Science. 1997 Aug 22;277(5329):1109-13 [9262482.001]
  • [Cites] Development. 2005 May;132(10):2425-39 [15843415.001]
  • [Cites] J Clin Oncol. 2005 Nov 1;23(31):7951-7 [16258095.001]
  • [Cites] Genes Dev. 2005 Nov 15;19(22):2656-67 [16260494.001]
  • [Cites] Neuron. 2005 Dec 22;48(6):933-47 [16364898.001]
  • [Cites] J Clin Oncol. 2006 Apr 20;24(12):1924-31 [16567768.001]
  • [Cites] Neuron. 2006 Apr 20;50(2):205-18 [16630833.001]
  • [Cites] Lancet Oncol. 2006 Oct;7(10):813-20 [17012043.001]
  • [Cites] J Neurosci. 2006 Nov 22;26(47):12226-36 [17122047.001]
  • [Cites] Annu Rev Pathol. 2008;3:341-65 [18039127.001]
  • [Cites] Cell Stem Cell. 2007 Oct 11;1(4):443-57 [18371380.001]
  • [Cites] Cancer Cell. 2008 Aug 12;14(2):123-34 [18691547.001]
  • [Cites] Cancer Cell. 2008 Aug 12;14(2):135-45 [18691548.001]
  • [Cites] PLoS One. 2008;3(8):e3088 [18769486.001]
  • [Cites] Development. 2009 Jan;136(2):295-305 [19088088.001]
  • [Cites] Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1880-5 [19164512.001]
  • [Cites] Neuroscience. 2009 Sep 1;162(3):560-73 [19303920.001]
  • [CommentIn] Nat Rev Cancer. 2011 Feb;11(2):79 [21322837.001]
  • [CommentIn] Nat Rev Cancer. 2011 Feb;11(2):80 [21436788.001]
  • (PMID = 21150899.001).
  • [ISSN] 1476-4687
  • [Journal-full-title] Nature
  • [ISO-abbreviation] Nature
  • [Language] ENG
  • [Databank-accession-numbers] GEO/ GSE24628
  • [Grant] United States / NCI NIH HHS / CA / R01 CA129541-04; United States / NCI NIH HHS / CA / R01 CA129541; United States / NCI NIH HHS / CA / R01CA129541; United States / NINDS NIH HHS / NS / R01 NS037956; United States / NCI NIH HHS / CA / R01 CA129541-02; United States / NCI NIH HHS / CA / R01 CA129541-05; United States / NCI NIH HHS / CA / R01 CA129541-03; United States / NCI NIH HHS / CA / P30CA021765; United States / NCI NIH HHS / CA / 01CA96832; United States / NCI NIH HHS / CA / P01 CA096832-06A18120; United States / NCI NIH HHS / CA / CA096832-078120; United States / NCI NIH HHS / CA / R01 CA129541-01; United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / P01 CA096832; United States / NINDS NIH HHS / NS / R01 NS037956-13; United States / NCI NIH HHS / CA / CA096832-06A18120; United States / NCI NIH HHS / CA / P01 CA096832-078120
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, mouse; 0 / beta Catenin
  • [Other-IDs] NLM/ NIHMS245937; NLM/ PMC3059767
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5. Yoshimura J, Nishiyama K, Fukuda M, Watanabe M, Igarashi H, Fujii Y: Adult cerebellopontine angle medulloblastoma originating in the pons mimicking focal brainstem tumor. J Neuroimaging; 2009 Oct;19(4):385-7
Hazardous Substances Data Bank. CHOLINE CHLORIDE .

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  • [Title] Adult cerebellopontine angle medulloblastoma originating in the pons mimicking focal brainstem tumor.
  • We herein report a rare case of cerebellopontine angle (CPA) medulloblastoma originating in the brainstem that demonstrated a very unusual clinical presentation and radiological appearances.
  • The histopathological diagnosis was medulloblastoma.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Cerebellopontine Angle / pathology. Infratentorial Neoplasms / pathology. Medulloblastoma / pathology. Pons / pathology
  • [MeSH-minor] Adult. Aspartic Acid / analogs & derivatives. Aspartic Acid / metabolism. Choline / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Functional Laterality. Humans. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy

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  • (PMID = 19021841.001).
  • [ISSN] 1552-6569
  • [Journal-full-title] Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • [ISO-abbreviation] J Neuroimaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; N91BDP6H0X / Choline
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6. Padovani L, André N, Carrie C, Muracciole X: [Childhood and adult medulloblastoma: what difference?]. Cancer Radiother; 2009 Oct;13(6-7):530-5
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  • [Title] [Childhood and adult medulloblastoma: what difference?].
  • Medulloblastoma is the most frequent childhood brain tumor (30%) but account only for less than 1% of adult brain tumor.
  • Due to the rarety in adult population, no prospective studies and few data about late effects are available.
  • Adult medulloblastoma is a therapeutic challenge and their therapeutic strategies are similar to pediatric protocols.
  • In order to improve the understanding of adult disease and to homogenize the treatment, National Cancer Institute (INCa) stimulated the creation of web conference to discuss each case prospectively and to propose a protocol of treatment.
  • A better comprehension of biological processes and abnormal cellular signalling pathways involved in medulloblastoma pathogenesis had led toward a new prognostic classification to adapt the therapeutic strategy and gives hope of new therapeutic tools.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adult. Age Factors. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Brain Neoplasms / epidemiology. Child. Cognition Disorders / epidemiology. Cognition Disorders / etiology. Combined Modality Therapy. France / epidemiology. Humans. Incidence. Molecular Biology / methods. Radiotherapy / adverse effects. Radiotherapy / methods. Surgical Procedures, Operative

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  • (PMID = 19713143.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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7. Razak AR, Nasser Q, Morris P, Alcutt D, Grogan L: Medulloblastoma in two successive pregnancies. J Neurooncol; 2005 May;73(1):89-90
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  • [Title] Medulloblastoma in two successive pregnancies.
  • Magnetic resonance imaging brain showed evidence of a cerebellar vermis lesion.
  • This was diagnosed as medulloblastoma on histopathological analysis.
  • We believe this is the first reported description of recurrent medulloblastoma in successive pregnancies.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Etoposide / therapeutic use. Female. Humans. Ifosfamide / therapeutic use. Pregnancy. Treatment Outcome. Vincristine / therapeutic use

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  • [Cites] Int J Radiat Oncol Biol Phys. 1990 Apr;18(4):763-72 [2323967.001]
  • [Cites] Clin Neurosurg. 1997;44:571-85 [10080028.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1998 Aug 1;42(1):143-6 [9747831.001]
  • [Cites] J Clin Oncol. 2003 Aug 15;21(16):3079-83 [12915597.001]
  • [Cites] J Clin Oncol. 1996 May;14(5):1526-31 [8622067.001]
  • [Cites] J Clin Oncol. 1995 Nov;13(11):2796-804 [7595741.001]
  • (PMID = 15933823.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; UM20QQM95Y / Ifosfamide; IVAD protocol
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8. Sousa R, Sá G, Reimão S, Lopes L, Ruivo J, Albuquerque L, Campos J: [Adult cerebellar medulloblastoma: imaging findings in eight cases]. Acta Med Port; 2006 Nov-Dec;19(6):466-70
Genetic Alliance. consumer health - Medulloblastoma.

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  • [Title] [Adult cerebellar medulloblastoma: imaging findings in eight cases].
  • Medulloblastoma is a brain tumor of neuroepithelial origin, frequent in children but rare in adults.
  • We report CT and MRI imaging findings of 8 adult patients with cerebellar medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / radiography. Medulloblastoma / pathology. Medulloblastoma / radiography
  • [MeSH-minor] Adolescent. Adult. Cerebellum / pathology. Cerebellum / radiography. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17583605.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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9. Brandes AA, Franceschi E, Tosoni A, Reni M, Gatta G, Vecht C, Kortmann RD: Adult neuroectodermal tumors of posterior fossa (medulloblastoma) and of supratentorial sites (stPNET). Crit Rev Oncol Hematol; 2009 Aug;71(2):165-79
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  • [Title] Adult neuroectodermal tumors of posterior fossa (medulloblastoma) and of supratentorial sites (stPNET).
  • Medulloblastoma and supratentorial primitive neuroectodermal tumors are rare diseases in adults.
  • Due to this rarity, few prospective clinical trials have been conducted on medulloblastoma in adults, investigations being based exclusively on retrospective studies; the populations considered in literature are small, and the different treatments given span decades, during which diagnostic procedures, neurosurgical skills and radiotherapy techniques have changed.
  • Unlike pediatric patients, adult medulloblastoma patients have been treated according to risk-adapted therapeutic strategies in only a few series and despite risk-tailored treatments, 20-30% of patients experience recurrence.
  • An important challenge for the future will be the biological characterization of medulloblastoma, with the identification of specific genetic patterns of patients with a better or a worse prognosis.
  • [MeSH-major] Brain Neoplasms. Medulloblastoma. Neuroectodermal Tumors, Primitive
  • [MeSH-minor] Adolescent. Adult. Child. Female. Genetic Predisposition to Disease. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Prognosis. Young Adult

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  • (PMID = 19303318.001).
  • [ISSN] 1879-0461
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 71
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10. Yoshimura J, Nishiyama K, Mori H, Takahashi H, Fujii Y: Intrathecal chemotherapy for refractory disseminated medulloblastoma. Childs Nerv Syst; 2008 May;24(5):581-5
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  • [Title] Intrathecal chemotherapy for refractory disseminated medulloblastoma.
  • OBJECTIVE: To analyze the effect of intrathecal (IT) chemotherapy for disseminated medulloblastoma.
  • CONCLUSION: IT chemotherapy was found to be effective in some cases with refractory disseminated medulloblastoma and it seems to be an appropriate treatment choice for leptomeningeal recurrence.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Immunosuppressive Agents / therapeutic use. Medulloblastoma / therapy. Methotrexate / therapeutic use. Nitrosourea Compounds / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Drug Therapy / methods. Female. Humans. Infant. Male. Neoplasm Recurrence, Local / prevention & control. Nimustine / therapeutic use. Retrospective Studies. Survival Analysis

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  • [Cites] J Clin Oncol. 2004 Oct 1;22(19):3916-21 [15459213.001]
  • [Cites] N Engl J Med. 1975 Jul 24;293(4):161-6 [806016.001]
  • [Cites] Paediatr Drugs. 2001;3(4):237-46 [11354696.001]
  • [Cites] Surg Neurol. 2005 Jan;63(1):52-5; discussion 55 [15639526.001]
  • [Cites] Cancer. 1975 Mar;35(3 suppl):965-72 [1111955.001]
  • [Cites] J Neurooncol. 1998 Jun-Jul;38(2-3):207-12 [9696373.001]
  • [Cites] Biol Pharm Bull. 2001 Apr;24(4):436-8 [11305611.001]
  • [Cites] Childs Brain. 1981;8(6):444-51 [6796342.001]
  • [Cites] Neurosurgery. 1993 Nov;33(5):817-23 [8264878.001]
  • [Cites] J Neurooncol. 1998 Jun-Jul;38(2-3):213-8 [9696374.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):978-86 [15758008.001]
  • (PMID = 18057943.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 0 / Nitrosourea Compounds; 0S726V972K / Nimustine; YL5FZ2Y5U1 / Methotrexate
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11. Holland H, Koschny R, Krupp W, Meixensberger J, Bauer M, Schober R, Kirsten H, Ganten TM, Ahnert P: Cytogenetic and molecular biological characterization of an adult medulloblastoma. Cancer Genet Cytogenet; 2007 Oct 15;178(2):104-13
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  • [Title] Cytogenetic and molecular biological characterization of an adult medulloblastoma.
  • Medulloblastoma is a malignant invasive embryonal tumor, occurring in children mainly.
  • It is rare in adults (<1% of adult brain tumors), and so comprehensive cytogenetic and molecular biological data on adult medulloblastomas are very limited.
  • We performed comprehensive cytogenetic analyses of an adult medulloblastoma, WHO grade IV, using trypsin-Giemsa staining (GTG-banding), multicolor fluorescence in situ hybridization (M-FISH), and locus-specific FISH, complemented by molecular karyotyping using high-density single nucleotide polymorphism (SNP) arrays.
  • Applying an upcoming therapeutic approach, we found that primary medulloblastoma cells were resistant to TRAIL, a novel anticancer cytokine, but could be efficiently sensitized by cotreatment with the proteasome inhibitor bortezomib.
  • Bortezomib-TRAIL cotreatment may serve as a powerful therapeutic option for medulloblastoma patients.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adult. Child. Chromosome Aberrations. Chromosome Banding. Female. Flow Cytometry. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. In Situ Hybridization, Fluorescence. Karyotyping. Matrix Metalloproteinase 2 / genetics. Phosphopyruvate Hydratase / genetics. Polymorphism, Single Nucleotide. Synaptophysin / genetics

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  • (PMID = 17954265.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Synaptophysin; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 4.2.1.11 / Phosphopyruvate Hydratase
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12. Pfister SM, Remke M, Benner A, Werft W, Mendrzyk F, Scheurlen W, Kulozik A, Lichter P, Korshunov A: Use of CDK6 oncogene amplification and 17q gain to predict poor clinical risk groups in adult medulloblastoma. J Clin Oncol; 2009 May 20;27(15_suppl):2030

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of CDK6 oncogene amplification and 17q gain to predict poor clinical risk groups in adult medulloblastoma.
  • : 2030 Background: While in children medulloblastoma comprises the most common malignant brain tumor, it accounts for only 1% of intracranial malignancies in adults.
  • METHODS: Array-CGH was performed for a total 34 adult medulloblastoma samples (>18 years) and results were compared with data from 101 pediatric patients.
  • Selected genomic regions were further investigated by FISH analysis in an independent cohort of 415 samples (112 adult and 303 pediatric).
  • All 146 adult patients received a standard treatment regimen consisting of tumor resection, irradiation of the neuroaxis with 36 Gy, a boost of 20-23 Gy to the posterior fossa, and eight cycles of vincristin, lomustine, and cisplatin.
  • RESULTS: Copy-number gains of chromosome 17q as well as high-level amplifications of CDK6 were identified as significant adverse prognostic markers in adult medulloblastoma.
  • Apart from one exception, CDK6 amplifications were only observed in adult patients (9% in adults versus 0.2 % in children), whereas amplifications of MYC or MYCN were significantly overrepresented in the pediatric cohort, but when present were also associated with dismal prognosis in adults.
  • Based on these results, we propose a molecular staging system for adult medulloblastoma: i) cases with oncogene amplification (10% of cases, 5-year OS = 0%);.
  • CONCLUSIONS: We report on the largest cohort of adult medulloblastoma investigated for genomic imbalances to date.
  • We propose a model for the molecular risk stratification of adult medulloblastoma comprising three distinct genomic risk groups with significantly different survival and tumor biology.

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  • (PMID = 27964634.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Spiller SE, Ravanpay AC, Hahn AW, Olson JM: Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma. J Neurooncol; 2006 Sep;79(3):259-70
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  • [Title] Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma.
  • PURPOSE: Suberoylanilide hydroxamic acid (SAHA) has been studied in adult solid and hematologic malignancies.
  • However, little information has been reported on the effects of SAHA on central nervous system (CNS) tumors including medulloblastoma, the most common malignant brain tumor in children.
  • We investigated SAHA in preclinical medulloblastoma models to determine its anti-cancer efficacy as well as its ability to affect intracranial lesions when administered systemically.
  • EXPERIMENTAL DESIGN AND RESULTS: Tissue culture studies were performed treating primary human fibroblasts, established medulloblastoma cell lines, and primary human medulloblastoma tumors with SAHA.
  • At 10 microM concentration, SAHA had little effect on normal fibroblasts but caused >90% apoptosis in cultured medulloblastoma cells.
  • In athymic mice with medulloblastoma xenograft tumors, oral SAHA resulted in apoptosis of tumor tissue and significantly slowed tumor growth.
  • In the ND2:Smo transgenic mouse medulloblastoma model, SAHA treatment caused significant apoptosis in these cerebellar tumors.
  • CONCLUSIONS: SAHA effectively induces cell death in established medulloblastoma cell lines, human patient primary tumor cultures, medulloblastoma xenografts and intracranial spontaneous medulloblastomas.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cerebellar Neoplasms / drug therapy. Hydroxamic Acids / pharmacology. Medulloblastoma / drug therapy

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  • [Cites] Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3578-88 [14506144.001]
  • [Cites] Cancer Cell. 2004 May;5(5):455-63 [15144953.001]
  • [Cites] Anticancer Res. 1999 Nov-Dec;19(6B):4999-5005 [10697502.001]
  • [Cites] FEBS Lett. 2003 Nov 20;554(3):347-50 [14623092.001]
  • [Cites] Cancer Lett. 2002 Dec 15;188(1-2):127-40 [12406558.001]
  • [Cites] Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10014-9 [10954755.001]
  • [Cites] Nat Med. 2003 Aug;9(8):1033-8 [12872164.001]
  • [Cites] J Biol Chem. 1979 Mar 10;254(5):1716-23 [762168.001]
  • [Cites] J Clin Oncol. 2006 Jan 1;24(1):166-73 [16330674.001]
  • [Cites] Eur Urol. 2004 Mar;45(3):382-9; author reply 389 [15036687.001]
  • [Cites] Cancer. 2002 Jan 15;94(2):552-60 [11900240.001]
  • [Cites] Lancet Oncol. 2004 Jul;5(7):399-408 [15231246.001]
  • [Cites] Science. 2002 Aug 30;297(5586):1559-61 [12202832.001]
  • [Cites] J Clin Oncol. 1999 Jul;17(7):2127-36 [10561268.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1241-6 [14734806.001]
  • [Cites] Neurosci Lett. 2005 Jun 10-17;381(1-2):69-73 [15882792.001]
  • [Cites] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6 [12576549.001]
  • [Cites] Cancer. 2003 Aug 15;98(4):841-53 [12910530.001]
  • [Cites] Mol Cancer Ther. 2002 Apr;1(6):385-92 [12477051.001]
  • [Cites] Lancet Oncol. 2004 Apr;5(4):209-18 [15050952.001]
  • [Cites] Oncogene. 1998 Apr 30;16(17):2283-5 [9619837.001]
  • [Cites] Prostate. 2004 May 1;59(2):177-89 [15042618.001]
  • [Cites] J Natl Cancer Inst. 2000 Aug 2;92(15):1210-6 [10922406.001]
  • [Cites] J Cell Sci. 2004 Sep 1;117(Pt 19):4481-94 [15316072.001]
  • [Cites] J Neurochem. 2005 May;93(4):992-9 [15857402.001]
  • [Cites] Cancer Res. 2004 Nov 1;64(21):7794-800 [15520185.001]
  • (PMID = 16645722.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA112350-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Hydroxamic Acids; 58IFB293JI / vorinostat
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14. Huse JT, Holland EC: Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer; 2010 May;10(5):319-31
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  • [Title] Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.
  • Malignant brain tumours continue to be the cause of a disproportionate level of morbidity and mortality across a wide range of individuals.
  • The most common variants in the adult and paediatric populations - malignant glioma and medulloblastoma, respectively - have been the subject of increasingly intensive research over the past two decades that has led to considerable advances in the understanding of their basic biology and pathogenesis.
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. Glioma / genetics. Medulloblastoma / genetics. Pathology, Molecular / trends


15. Wendland MM, Shrieve DC, Watson GA, Chin SS, Blumenthal DT: Extraneural metastatic medulloblastoma in an adult. J Neurooncol; 2006 Jun;78(2):191-6
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  • [Title] Extraneural metastatic medulloblastoma in an adult.
  • Medulloblastoma is a rare malignancy in adults, accounting for approximately 1% of all primary brain tumors.
  • We report here our experience with a 26 year-old woman with medulloblastoma treated with gross total resection followed by radiation therapy to her craniospinal axis.
  • The treatment of medulloblastoma, particularly salvage therapy following disease recurrence, is reviewed.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / secondary. Brain Neoplasms / pathology. Medulloblastoma / secondary
  • [MeSH-minor] Adult. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Radiotherapy Dosage. Salvage Therapy. Treatment Outcome

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  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1145-52 [7607936.001]
  • [Cites] J Neurosurg. 1991 Jun;74(6):872-7 [2033446.001]
  • [Cites] Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2 [10981749.001]
  • [Cites] Cancer. 1984 Feb 15;53(4):974-81 [6692295.001]
  • [Cites] Med Pediatr Oncol. 1995 Sep;25(3):166-78 [7623725.001]
  • [Cites] Neuro Oncol. 2001 Jan;3(1):29-34 [11305414.001]
  • [Cites] Cancer. 1991 Oct 1;68(7):1600-4 [1893359.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1982 Nov;8(11):2023-7 [6759487.001]
  • [Cites] Med Pediatr Oncol. 1986;14(6):329-31 [3784985.001]
  • [Cites] Neurosurgery. 1988 Oct;23(4):476-9 [3200378.001]
  • [Cites] Cancer. 1981 Nov 15;48(10 ):2296-309 [7296479.001]
  • [Cites] J Neurooncol. 1997 Apr;32(2):149-54 [9120544.001]
  • [Cites] Cancer. 1994 Oct 1;74(7):1887-90 [7521785.001]
  • [Cites] Med Pediatr Oncol. 2003 Jun;40(6):396-7 [12692812.001]
  • [Cites] J Clin Oncol. 1999 Jul;17(7):2127-36 [10561268.001]
  • [Cites] J Neurooncol. 1984;2(3):223-35 [6502196.001]
  • [Cites] Bone Marrow Transplant. 2002 Nov;30(9):565-9 [12407430.001]
  • [Cites] J Clin Oncol. 1998 Jan;16(1):222-8 [9440746.001]
  • [Cites] J Clin Oncol. 2000 Aug;18(16):3004-11 [10944134.001]
  • [Cites] Neuro Oncol. 2001 Jul;3(3):167-73 [11465397.001]
  • [Cites] Clin Nucl Med. 1993 Oct;18(10 ):821-8 [7694820.001]
  • (PMID = 16598430.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Barai S, Bandopadhayaya GP, Julka PK, Kale SS, Kumar R, Malhotra A, Haloi AK, Seith A, Naik KK, Dhanapathi H: Evaluation of Tc99m-glucoheptonate for SPECT functional imaging of medulloblastoma. J Clin Neurosci; 2005 Jan;12(1):36-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of Tc99m-glucoheptonate for SPECT functional imaging of medulloblastoma.
  • OBJECTIVES: Functional imaging of medulloblastoma using SPECT has been a difficult problem as this tumour does not concentrate conventional brain tumour imaging radiopharmaceuticals.
  • This study aimed to evaluate Tc99m-glucoheptonate as a "brain tumour-seeking" radiopharmaceutical for functional imaging of medulloblastoma.
  • METHODS: Tc99m-glucoheptonate brain SPECT was performed in 27 patients with medulloblastoma after radiation therapy and with clinical suspicion of tumour recurrence.
  • Histopathology confirmed viable medulloblastoma in all cases.
  • CONCLUSION: Tc99m-glucoheptonate is an ideal SPECT tracer for functional evaluation of medulloblastoma.
  • SPECT utilising Tc99m-glucoheptonate is a reliable diagnostic modality to differentiate tumour recurrence from post-radiation gliosis in patients with medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / radionuclide imaging. Medulloblastoma / radionuclide imaging. Organotechnetium Compounds. Radiopharmaceuticals. Sugar Acids
  • [MeSH-minor] Adolescent. Adult. Child. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neurosurgical Procedures. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 15639408.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / Sugar Acids; I853LE095B / technetium Tc 99m gluceptate
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17. Xu P, Pu PY, Kang CS, Jia ZF, Zhou X, Wang GX: [Differential expression of Notch1 and Notch2 in astrocytoma and medulloblastoma]. Zhonghua Bing Li Xue Za Zhi; 2008 Jul;37(7):450-3
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  • [Title] [Differential expression of Notch1 and Notch2 in astrocytoma and medulloblastoma].
  • OBJECTIVE: To detect the differential expression of Notch1 and Notch2 in human astrocytoma and medulloblastoma; and to study the role of Notch1 and Notch2 in the development of both tumors.
  • METHODS: Immunohistochemical staining (SP method) and Western blot analysis were used to detect Notch1 and Notch2 expression in tissue arrays and freshly resected samples of normal brain tissue, astrocytoma and medulloblastoma.
  • RESULTS: Notch1 and Notch2 were negative in normal human brain tissue.
  • On the other hand, overexpression of Notch2 was detected in medulloblastoma (9/10) in contrast with lower expression of Notch1 (2/10).
  • CONCLUSIONS: Notch1 and Notch2 show differential expression in astrocytoma and medulloblastoma.
  • This may be related to their different functional activities during the process of brain development.
  • [MeSH-major] Astrocytoma / metabolism. Biomarkers, Tumor / metabolism. Medulloblastoma / metabolism. Receptor, Notch1 / metabolism. Receptor, Notch2 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Brain / metabolism. Brain Neoplasms / metabolism. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19035115.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptor, Notch1; 0 / Receptor, Notch2
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18. Poelen J, Bernsen HJ, Prick MJ: Metastatic medulloblastoma in an adult; treatment with temozolomide. Acta Neurol Belg; 2007 Jun;107(2):51-4
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  • [Title] Metastatic medulloblastoma in an adult; treatment with temozolomide.
  • Medulloblastoma is a malignant brain tumour most frequently seen in children.
  • Relapses of medulloblastoma are sensitive to chemotherapy and treatment with chemotherapeutics in children has increased the survival rates.
  • A medulloblastoma at adult age is extremely rare, and there is no overall accepted treatment, especially not in the case of a relapse.
  • This observation encouraged us to decide to treat an adult patient with a recurrent medulloblastoma with temozolomide.
  • This female patient showed a recurrence of a medulloblastoma 7 years after the initial presentation with metastatic spread along the neuraxis and progressive neurological deterioration.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Cerebellar Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / secondary

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  • (PMID = 17710841.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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19. Tabori U, Sung L, Hukin J, Laperriere N, Crooks B, Carret AS, Silva M, Odame I, Mpofu C, Strother D, Wilson B, Samson Y, Bouffet E, Canadian Pediatric Brain Tumor Consortium: Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma. Int J Radiat Oncol Biol Phys; 2006 Feb 1;64(2):402-7
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  • [Title] Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma.
  • PURPOSE: To report the clinical course of adolescents with medulloblastoma, with specific emphasis on prognosis and pattern of relapse.
  • METHODS AND MATERIALS: We retrospectively studied the clinical course and outcomes of children aged 10-20 years with medulloblastoma, treated at centers throughout Canada between 1986 and 2003.
  • CONCLUSIONS: Our study suggests that adolescents with medulloblastoma might have a unique prognosis and pattern of relapse, dissimilar to those in younger children.
  • [MeSH-major] Cerebellar Neoplasms / mortality. Medulloblastoma / mortality. Neoplasm Recurrence, Local / mortality
  • [MeSH-minor] Adolescent. Adult. Age Factors. Analysis of Variance. Child. Disease-Free Survival. Female. Humans. Male. Prognosis. Recurrence. Retrospective Studies. Sex Factors

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  • (PMID = 16198067.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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20. Menon G, Krishnakumar K, Nair S: Adult medulloblastoma: clinical profile and treatment results of 18 patients. J Clin Neurosci; 2008 Feb;15(2):122-6
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  • [Title] Adult medulloblastoma: clinical profile and treatment results of 18 patients.
  • The objective of this article is to examine the clinicoradiological features and surgical outcomes of adult patients (>16 years) with medulloblastoma.
  • An attempt was made to identify the predictors of poor outcome and assess patterns of relapse and to compare these with pediatric medulloblastoma.
  • In spite of recent advances in management, patients with medulloblastoma still have a poor prognosis.
  • Desmoplastic variant histology was not observed to be a significant prognostic factor in the adult group while brain stem invasion carried a poor prognosis.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Clinical Trials as Topic. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Statistics, Nonparametric. Treatment Outcome

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  • (PMID = 18078755.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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21. Rushing EJ, Smith AB, Smirniotopoulos JG, Douglas AF, Zeng W, Azumi N: Occult leptomeningeal large cell medulloblastoma in an adult. Clin Neuropathol; 2009 May-Jun;28(3):188-92
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  • [Title] Occult leptomeningeal large cell medulloblastoma in an adult.
  • OBJECTIVE AND IMPORTANCE: Large cell medulloblastoma is an uncommon malignancy of childhood that often pursues an aggressive clinical course.
  • We report the first case of this entity in an adult that proved to be an unsuspected primary leptomeningeal tumor.
  • Postmortem examination of the brain was notable for necrotic cerebellar tonsils, but demonstrated no evidence of an intraparenchymal mass lesion.
  • Microscopic examination of the cerebellum revealed discohesive neoplastic cells, which showed characteristic dot-like immunoreactivity for synaptophysin, diagnostic of large cell medulloblastoma within the subarachnoid space.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Medulloblastoma / pathology. Meningeal Neoplasms / pathology
  • [MeSH-minor] Adult. Arnold-Chiari Malformation / complications. Fatal Outcome. Humans. Intervertebral Disc Displacement / complications. Magnetic Resonance Imaging. Male

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  • (PMID = 19537136.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Herrlinger U, Steinbrecher A, Rieger J, Hau P, Kortmann RD, Meyermann R, Schabet M, Bamberg M, Dichgans J, Bogdahn U, Weller M: Adult medulloblastoma: prognostic factors and response to therapy at diagnosis and at relapse. J Neurol; 2005 Mar;252(3):291-9
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  • [Title] Adult medulloblastoma: prognostic factors and response to therapy at diagnosis and at relapse.
  • Adult medulloblastoma is a rare tumor with few retrospective studies published so far.
  • This study reports therapy and outcome in all adult (>or=16 years old) medulloblastoma (n=34) and supratentorial primitive neuroectodermal tumor (PNET) patients (n=2) treated in 2 neuro-oncological centers between 1976 and 2002.
  • In conclusion, adjuvant chemotherapy may prolong survival in adult medulloblastoma patients.
  • As in pediatric medulloblastoma patients, primary infiltration of the floor of the 4(th) ventricle indicates a poor prognosis.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Combined Modality Therapy. Demography. Disease Progression. Disease-Free Survival. Dose-Response Relationship, Radiation. Drug Therapy / methods. Female. Humans. Male. Middle Aged. Radiotherapy, High-Energy / methods. Recurrence. Regression Analysis. Retrospective Studies. Risk Factors. Time Factors. Treatment Outcome

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  • [Cites] Int J Radiat Oncol Biol Phys. 1990 Apr;18(4):763-72 [2323967.001]
  • [Cites] J Clin Oncol. 1999 Mar;17(3):832-45 [10071274.001]
  • [Cites] Int J Cancer. 1999 Mar 1;80(5):689-92 [10048968.001]
  • [Cites] J Neurosurg. 1990 Apr;72(4):572-82 [2319316.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1145-52 [7607936.001]
  • [Cites] Eur J Cancer. 1990 Apr;26(4):464-9 [2141512.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2002 Nov 1;54(3):855-60 [12377339.001]
  • [Cites] Cancer. 1994 Oct 15;74(8):2352-60 [7922986.001]
  • [Cites] Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2 [10981749.001]
  • [Cites] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840.001]
  • [Cites] Cancer Treat Rev. 1999 Feb;25(1):3-12 [10212586.001]
  • [Cites] Neuro Oncol. 2001 Jan;3(1):29-34 [11305414.001]
  • [Cites] Neurosurgery. 1996 Feb;38(2):265-71 [8869053.001]
  • [Cites] J Clin Oncol. 2002 Feb 1;20(3):842-9 [11821469.001]
  • [Cites] Cancer. 1999 Jul 1;86(1):142-8 [10391574.001]
  • [Cites] J Clin Oncol. 1999 Jul;17(7):2127-36 [10561268.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jun 1;47(3):573-84 [10837938.001]
  • [Cites] Bone Marrow Transplant. 2002 Nov;30(9):565-9 [12407430.001]
  • [Cites] Neurology. 1995 Mar;45(3 Pt 1):440-2 [7898692.001]
  • [Cites] J Clin Oncol. 2003 Apr 15;21(8):1581-91 [12697884.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):269-79 [10661332.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):951-7 [7607969.001]
  • [Cites] J Clin Oncol. 1998 Jan;16(1):222-8 [9440746.001]
  • [Cites] J Neurosurg. 1994 Nov;81(5):690-8 [7931615.001]
  • [Cites] J Clin Oncol. 2000 Aug;18(16):3004-11 [10944134.001]
  • [Cites] Med Pediatr Oncol. 2002 Aug;39(2):99-108 [12116057.001]
  • [Cites] Radiology. 1969 Dec;93(6):1351-9 [4983156.001]
  • (PMID = 16189725.001).
  • [ISSN] 0340-5354
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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23. Howes TL, Buatti JM, Kirby PA, Carlisle TL, Ryken TC: Radiation induced adult medulloblastoma: a case report. J Neurooncol; 2006 Nov;80(2):191-4
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  • [Title] Radiation induced adult medulloblastoma: a case report.
  • Adult medulloblastoma is a rare intracranial tumor.
  • Our patient is a 61 year old woman treated with cranial irradiation 15 years previously for a low grade astrocytoma in the left posterior temporal lobe that was recently diagnosed with medulloblastoma in the right cerebellum.
  • This is the first reported case of radiation induced adult medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / etiology. Medulloblastoma / etiology. Neoplasms, Radiation-Induced / pathology
  • [MeSH-minor] Astrocytoma / radiotherapy. Brain Neoplasms / radiotherapy. Craniotomy. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Temporal Lobe / pathology

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  • [Cites] J Neurol Neurosurg Psychiatry. 2004 Jun;75 Suppl 2:ii2-11 [15146033.001]
  • [Cites] Tumori. 2003 Jul-Aug;89(4):443-7 [14606653.001]
  • [Cites] Cancer. 1994 Oct 15;74(8):2352-60 [7922986.001]
  • [Cites] J Neurooncol. 1997 Nov;35(2):169-76 [9266455.001]
  • [Cites] Health Phys. 2003 Jul;85(1):43-6 [12852470.001]
  • [Cites] Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2 [10981749.001]
  • [Cites] Cancer Treat Rev. 1999 Feb;25(1):3-12 [10212586.001]
  • [Cites] J Clin Oncol. 2002 May 1;20(9):2267-76 [11980997.001]
  • [Cites] Surg Neurol. 2003 Jul;60(1):60-7; discussion 67 [12865017.001]
  • [Cites] J Clin Oncol. 2002 May 1;20(9):2223-4 [11980992.001]
  • [Cites] Lancet Neurol. 2003 Jul;2(7):395-403 [12849117.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1996 Oct 1;36(3):549-56 [8948338.001]
  • [Cites] Cancer. 1948 May;1(1):3-29 [18867438.001]
  • (PMID = 16710747.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Korshunov A, Benner A, Remke M, Lichter P, von Deimling A, Pfister S: Accumulation of genomic aberrations during clinical progression of medulloblastoma. Acta Neuropathol; 2008 Oct;116(4):383-90
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  • [Title] Accumulation of genomic aberrations during clinical progression of medulloblastoma.
  • Medulloblastomas comprise the most frequent malignant brain tumor in childhood and one of the biggest challenges in pediatric oncology.
  • The current concept suggests that these tumors may undergo stepwise progression as it has been shown for other brain tumors.
  • However, conclusive evidence of molecular progression over time has not been demonstrated yet for medulloblastoma.
  • In the present study, 28 pairs of medulloblastoma at primary diagnosis and at the time of recurrence, either occurring as local tumor regrowth or tumor dissemination, were histopathologically and molecularly analyzed.
  • These results suggest that early recurrence in medulloblastoma mainly occurs in tumors with a highly malignant genotype and phenotype per se, whereas late recurrence is often dependent on tumor evolution toward a more malignant biology.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 17 / genetics. Chromosomes, Human, Pair 6 / genetics. Medulloblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. Proto-Oncogene Proteins c-myc / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Cytogenetic Analysis. Disease Progression. Female. Humans. Male. Neoplasm Recurrence, Local / genetics. Prognosis

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  • (PMID = 18704466.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYC protein, human; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Proto-Oncogene Proteins c-myc
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25. Zawlik I, Zakrzewska M, Witusik M, Golanska E, Kulczycka-Wojdala D, Szybka M, Piaskowski S, Wozniak K, Zakrzewski K, Papierz W, Liberski PP, Rieske P: KCTD11 expression in medulloblastoma is lower than in adult cerebellum and higher than in neural stem cells. Cancer Genet Cytogenet; 2006 Oct 1;170(1):24-8
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  • [Title] KCTD11 expression in medulloblastoma is lower than in adult cerebellum and higher than in neural stem cells.
  • Medulloblastoma (MB) is the most common malignant brain tumor of childhood, and the most frequent associated genetic alteration is loss of heterozygosity on chromosome region 7p13.
  • We used real-time polymerase chain reaction in 20 tissue samples of primary MB to examine the transcriptional level of the two genes, with reference to two types of controls: adult cerebellum and fetal neural stem cells.
  • A significant reduction of KCTD11 expression relative to adult normal cerebellum was detected in 14 of 20 (70%) of MB samples.
  • HIC1 gene expression was low ( approximately 100 times lower than KCTD11 expression) in MB, and low also in both adult cerebellum and neural stem cells.
  • [MeSH-major] Cerebellum / metabolism. Medulloblastoma / genetics. Nervous System / metabolism. Potassium Channels / genetics. Stem Cells / metabolism

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  • (PMID = 16965951.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / HIC1 protein, human; 0 / KCTD11 protein, human; 0 / Kruppel-Like Transcription Factors; 0 / Potassium Channels; 0 / Transcription Factors
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26. Viana-Pereira M, Almeida I, Sousa S, Mahler-Araújo B, Seruca R, Pimentel J, Reis RM: Analysis of microsatellite instability in medulloblastoma. Neuro Oncol; 2009 Oct;11(5):458-67
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  • [Title] Analysis of microsatellite instability in medulloblastoma.
  • Medulloblastoma is the most common malignant brain tumor in children.
  • The presence of microsatellite instability (MSI) in brain tumors, particularly medulloblastomas, has not been properly addressed.
  • The aim of the present study was to evaluate the role of MSI in medulloblastoma carcinogenesis.
  • We observed the presence of MSI together with mutations of MSI target genes in a small fraction of cases, suggesting a new genetic pathway for a role in medulloblastoma development.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Microsatellite Instability
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. DNA Methylation. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Young Adult

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  • [Cites] Ann Genet. 2002 Apr-Jun;45(2):71-5 [12119215.001]
  • [Cites] Oncogene. 2002 Jul 18;21(31):4863-71 [12101426.001]
  • [Cites] Cancer Res. 2003 Sep 15;63(18):5738-44 [14522894.001]
  • [Cites] Cancer. 2003 Nov 15;98(10):2199-206 [14601090.001]
  • [Cites] J Natl Cancer Inst. 2004 Feb 18;96(4):261-8 [14970275.001]
  • [Cites] Lancet Oncol. 2004 Apr;5(4):209-18 [15050952.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1982 Nov;8(11):2023-7 [6759487.001]
  • [Cites] Nat Genet. 1994 Feb;6(2):152-6 [8162069.001]
  • [Cites] Cancer Res. 1995 Dec 1;55(23):5545-7 [7585631.001]
  • [Cites] Cancer Genet Cytogenet. 1995 Oct 1;84(1):56-9 [7497444.001]
  • [Cites] Cancer Res. 1997 Nov 1;57(21):4749-56 [9354436.001]
  • [Cites] Cancer Res. 1998 Mar 1;58(5):896-9 [9500446.001]
  • [Cites] Clin Cancer Res. 1998 Jun;4(6):1415-9 [9626457.001]
  • [Cites] Cancer Res. 1998 Nov 15;58(22):5248-57 [9823339.001]
  • [Cites] Cancer Res. 1999 Jan 15;59(2):294-7 [9927034.001]
  • [Cites] Oncol Res. 1998;10(8):421-8 [10100759.001]
  • [Cites] Cancer Res. 1999 Jun 15;59(12):2995-3002 [10383166.001]
  • [Cites] Cancer Res. 1999 Jul 15;59(14):3346-51 [10416591.001]
  • [Cites] Cancer Res. 1999 Sep 1;59(17):4213-5 [10485457.001]
  • [Cites] Dis Markers. 2004;20(4-5):251-7 [15528790.001]
  • [Cites] J Cancer Res Clin Oncol. 2005 Feb;131(2):87-93 [15672285.001]
  • [Cites] Acta Neuropathol. 2005 Feb;109(2):207-10 [15791479.001]
  • [Cites] Ann Hematol. 2005 Jun;84(6):368-75 [15789228.001]
  • [Cites] Nucleic Acids Res. 2005;33(14):e128 [16106041.001]
  • [Cites] J Clin Oncol. 2006 Jan 10;24(2):241-51 [16330668.001]
  • [Cites] Oncogene. 2006 Mar 30;25(14):2113-8 [16288216.001]
  • [Cites] Carcinogenesis. 2006 May;27(5):951-5 [16490738.001]
  • [Cites] Virchows Arch. 2006 Aug;449(2):238-43 [16639607.001]
  • [Cites] Cancer Biomark. 2006;2(1-2):69-86 [17192061.001]
  • [Cites] Nat Clin Pract Oncol. 2007 Feb;4(2):130-4 [17259933.001]
  • [Cites] Br J Cancer. 2007 Feb 26;96(4):660-6 [17285135.001]
  • [Cites] Brain Pathol. 2007 Apr;17(2):146-50 [17388945.001]
  • [Cites] Cancer. 2007 Jun 1;109(11):2349-56 [17440981.001]
  • [Cites] Eur J Hum Genet. 2007 Sep;15(9):922-9 [17534377.001]
  • [Cites] J Cancer Res Clin Oncol. 2007 Oct;133(10):749-59 [17530287.001]
  • [Cites] Oncogene. 2007 Aug 30;26(40):5919-26 [17384679.001]
  • [Cites] Lab Invest. 2007 Oct;87(10):1055-65 [17700563.001]
  • [Cites] Genes Chromosomes Cancer. 2007 Dec;46(12):1061-8 [17879369.001]
  • [Cites] DNA Repair (Amst). 2008 Feb 1;7(2):321-8 [18162445.001]
  • [Cites] J Clin Pathol. 2008 Feb;61(2):203-8 [17827398.001]
  • [Cites] Clin Cancer Res. 2008 Feb 15;14(4):971-6 [18281528.001]
  • [Cites] Neuropathol Appl Neurobiol. 2008 Oct;34(5):547-54 [18053027.001]
  • [Cites] Cancer Sci. 2006 Mar;97(3):226-34 [16542220.001]
  • [Cites] Nat Genet. 1999 Nov;23(3):266-8 [10545939.001]
  • [Cites] Hum Pathol. 1999 Nov;30(11):1284-90 [10571506.001]
  • [Cites] Trends Cell Biol. 1999 Dec;9(12):M57-60 [10611684.001]
  • [Cites] Am J Pathol. 2000 Feb;156(2):433-7 [10666372.001]
  • [Cites] Oncogene. 2000 Mar 16;19(12):1564-71 [10734316.001]
  • [Cites] Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2 [10981749.001]
  • [Cites] Virchows Arch. 2001 Jan;438(1):39-48 [11213834.001]
  • [Cites] J Cell Physiol. 2001 May;187(2):137-44 [11267993.001]
  • [Cites] Cancer Res. 2001 Mar 1;61(5):2124-8 [11280776.001]
  • [Cites] Cancer Res. 2001 Apr 1;61(7):3139-44 [11306499.001]
  • [Cites] Am J Pathol. 2001 Dec;159(6):2107-16 [11733361.001]
  • [Cites] Clin Cancer Res. 2002 Jan;8(1):138-43 [11801550.001]
  • [Cites] Clin Neuropathol. 2003 Jul-Aug;22(4):180-6 [12908754.001]
  • (PMID = 19179424.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2765336
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27. Siu IM, Bai R, Gallia GL, Edwards JB, Tyler BM, Eberhart CG, Riggins GJ: Coexpression of neuronatin splice forms promotes medulloblastoma growth. Neuro Oncol; 2008 Oct;10(5):716-24
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  • [Title] Coexpression of neuronatin splice forms promotes medulloblastoma growth.
  • Medulloblastoma (MB) is the most common pediatric brain cancer.

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  • [Cites] Dev Biol. 1995 Sep;171(1):73-84 [7556909.001]
  • [Cites] Oncogene. 2004 Apr 22;23(19):3444-53 [15064731.001]
  • [Cites] Brain Res. 1995 Aug 28;690(1):92-8 [7496812.001]
  • [Cites] Brain Res. 1996 Jun 3;723(1-2):8-22 [8813377.001]
  • [Cites] Cancer Res. 1997 Mar 1;57(5):842-5 [9041183.001]
  • [Cites] Am J Pathol. 1997 May;150(5):1805-13 [9137103.001]
  • [Cites] Nucleic Acids Res. 1997 Sep 1;25(17):3428-32 [9254699.001]
  • [Cites] Dev Biol. 1997 Oct 1;190(1):66-77 [9331332.001]
  • [Cites] J Mol Neurosci. 1997 Aug;9(1):55-60 [9356927.001]
  • [Cites] Genes Dev. 1999 Jul 1;13(13):1647-52 [10398678.001]
  • [Cites] Cancer Res. 2004 Nov 1;64(21):7787-93 [15520184.001]
  • [Cites] Mol Cancer Ther. 2005 Jan;4(1):151-68 [15657362.001]
  • [Cites] Cancer Res. 2005 Feb 1;65(3):703-7 [15705863.001]
  • [Cites] Diabetes. 2005 Apr;54(4):1064-73 [15793245.001]
  • [Cites] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W741-8 [15980575.001]
  • [Cites] Cancer Res. 2006 Jan 15;66(2):673-81 [16423996.001]
  • [Cites] Clin Cancer Res. 2006 May 15;12(10):3019-27 [16707597.001]
  • [Cites] J Thorac Oncol. 2007 Sep;2(9):796-801 [17805055.001]
  • [Cites] Science. 2000 Aug 18;289(5482):1197-202 [10947988.001]
  • [Cites] Genome Res. 2000 Sep;10(9):1393-402 [10984457.001]
  • [Cites] Dev Biol. 2001 Aug 15;236(2):387-99 [11476579.001]
  • [Cites] Genomics. 2001 Sep;77(1-2):99-104 [11543638.001]
  • [Cites] Oncogene. 2003 Oct 23;22(48):7687-94 [14576832.001]
  • [Cites] Biol Reprod. 2004 Apr;70(4):1131-5 [14668210.001]
  • [Cites] Science. 1995 Oct 20;270(5235):484-7 [7570003.001]
  • (PMID = 18701710.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS052507-02; United States / NINDS NIH HHS / NS / R01 NS052507; United States / NINDS NIH HHS / NS / NS052507; United States / NINDS NIH HHS / NS / R01 NS052507-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / NNAT protein, human; 0 / Nerve Tissue Proteins; 0 / Protein Isoforms
  • [Other-IDs] NLM/ PMC2666248
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28. Hoffman S, Schellinger KA, Propp JM, McCarthy BJ, Campbell RT, Davis FG: Seasonal variation in incidence of pediatric medulloblastoma in the United States, 1995-2001. Neuroepidemiology; 2007;29(1-2):89-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seasonal variation in incidence of pediatric medulloblastoma in the United States, 1995-2001.
  • BACKGROUND/AIMS: Brain tumors are the second most common pediatric malignancy.
  • The literature suggests that one of the most common subtypes of malignant childhood brain tumor, medulloblastoma, has some seasonal variation in incidence by month of birth.
  • METHODS: Data from cases in the Central Brain Tumor Registry of the United States, including primary brain tumor cases diagnosed in children (0-19 years) between the years 1995 and 2001 from 13 state cancer registries, were analyzed to determine whether there was seasonal variation.
  • RESULTS: Seasonal variation in incidence by month of birth was highly statistically significant for medulloblastoma, not otherwise specified (NOS) (p = 0.016), with the peak occurring in October.
  • Medulloblastoma, NOS also demonstrated seasonal variation in incidence by month of birth in children aged 5-19 (p = 0.041), especially females aged 5-19 (p = 0.034), with the peak in October.
  • There were no significant results for brain tumors overall, or for the other most common pediatric tumor subtypes (pilocytic astrocytoma, other astrocytoma, and ependymoma).
  • CONCLUSION: These preliminary results indicate seasonal variation unique to medulloblastoma incidence by month of birth and may provide evidence for an environmental exposure etiology, though further studies are needed to explore specific hypotheses.
  • [MeSH-major] Cerebellar Neoplasms / epidemiology. Medulloblastoma / epidemiology. Parturition. Seasons
  • [MeSH-minor] Adolescent. Adult. Birth Rate. Child. Child, Preschool. Female. Humans. Incidence. Male. Registries. United States / epidemiology

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17925600.001).
  • [ISSN] 1423-0208
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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29. Shim KW, Joo SY, Kim SH, Choi JU, Kim DS: Prediction of prognosis in children with medulloblastoma by using immunohistochemical analysis and tissue microarray. J Neurosurg Pediatr; 2008 Mar;1(3):196-205
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  • [Title] Prediction of prognosis in children with medulloblastoma by using immunohistochemical analysis and tissue microarray.
  • OBJECTIVES: Medulloblastoma is the most common malignant neuroepithelial tumor found in children.
  • Several reports have described efforts to identify the prognostic significance of various patterns of pathological and immunohistochemical features in medulloblastoma, but the published data appear to be controversial.
  • The authors therefore attempted to demonstrate these prognostic factors convincingly in a retrospective study performed in patients with medulloblastoma.
  • METHODS: The data used were obtained in 58 patients with medulloblastoma who were > 3 years of age and in whom > 1 year of follow-up was available after the maximal resection, craniospinal irradiation, and chemotherapy treatments.
  • The number of cases with a PI > 10% was significantly greater in the group of tumors in patients with recurrent medulloblastoma.
  • Most importantly, the PI is the only significant prognostic factor for the overall survival of patients with medulloblastoma.
  • CONCLUSIONS: Therefore, the authors suggest that the PI is directly linked to the prognostic factor for medulloblastoma and that immunohistochemical staining is a potentially powerful tool for predicting the prognosis of patients with medulloblastoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adolescent. Adult. Apoptosis / physiology. Cell Differentiation / physiology. Cell Proliferation. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Follow-Up Studies. Forecasting. Humans. Immunohistochemistry. Male. Microarray Analysis. Neoadjuvant Therapy. Neoplasm Recurrence, Local / pathology. Prognosis. Radiotherapy, Adjuvant. Receptor, ErbB-3 / analysis. Receptor, trkC / analysis. Retrospective Studies. Treatment Outcome


30. Jea A, Coscarella E, Chintagumpala M, Bhattacharjee M, Whitehead WE, Curry DJ, Luerssen TG: Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. J Neurosurg Pediatr; 2010 Feb;5(2):149-54
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  • [Title] Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report.
  • Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type have been published in the adult and pediatric literature.
  • However, the simultaneous occurrence of multiple primary brain tumors with different cell types is rare.
  • Even more rare is the pediatric presentation of multiple primary brain tumors with different cell types.
  • Brain MR imaging demonstrated a heterogeneously enhancing mixed solid/cystic mass of the left cerebellar hemisphere and a larger, midline, more homogeneously enhancing lesion of the superior vermis.
  • Pathological examination revealed the left cerebellar and superior vermian lesions to be a juvenile pilocytic astrocytoma and a medulloblastoma, respectively.
  • To the best of the authors' knowledge, they describe the first known pediatric case in which a medulloblastoma and a juvenile pilocytic astrocytoma presented as synchronous primary brain tumors.
  • They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cerebellar Neoplasms / pathology. Medulloblastoma / pathology


31. Shu XH, Li H, Sun Z, Wu ML, Ma JX, Wang JM, Wang Q, Sun Y, Fu YS, Chen XY, Kong QY, Liu J: Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells. Biochem Pharmacol; 2010 May 15;79(10):1516-25
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  • [Title] Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells.
  • This issue was addressed here by identifying the metabolic pattern and the bioactive form of resveratrol in a resveratrol-sensitive human medulloblastoma cell line, UW228-3.
  • The cell lysates and condition media of UW228-3 cells with or without 100 microM resveratrol treatment were analyzed by HPLC and LC/MS which revealed (1) that resveratrol was chemically unstable and the spontaneous generation of cis-resveratrol reduced resveratrol's anti-medulloblastoma efficacy and (2) that resveratrol monosulfate was the major metabolite of the cells.
  • To identify the bioactive form of resveratrol, a mixture-containing approximately half fraction of resveratrol monosulfate was prepared by incubating trans-resveratrol with freshly prepared rat brain lysates.
  • Medulloblastoma cells treated by 100 microM of this mixture showed attenuated cell crisis.
  • The overall levels of the three brain-associated sulfotransferases (SULT1A1, 1C2 and 4A1) were low in medulloblastoma cells in vivo and in vitro in comparison with that in human noncancerous and rat normal cerebella; resveratrol could more or less up-regulate the production of these enzymes in UW228-3 cells but their overall level was still lower than that in normal cerebellum tissue.
  • Our study thus demonstrated for the first time that trans-resveratrol is the bioactive form in medulloblastoma cells in which the expression of brain-associated SULTs was down-regulated, resulting in the increased intracellular bioavailability and anti-medulloblastoma efficacy of trans-resveratrol.
  • [MeSH-major] Antineoplastic Agents / metabolism. Antineoplastic Agents / pharmacokinetics. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Stilbenes / pharmacokinetics
  • [MeSH-minor] Adolescent. Animals. Biotransformation. Blotting, Western. Cell Line, Tumor. Child. Chromatography, High Pressure Liquid. Humans. Rats. Reverse Transcriptase Polymerase Chain Reaction. Sulfotransferases / metabolism. Young Adult

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20105429.001).
  • [ISSN] 1873-2968
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Stilbenes; EC 2.8.2.- / Sulfotransferases; Q369O8926L / resveratrol
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32. Roland JT Jr, Cosetti M, Liebman T, Waltzman S, Allen JC: Cochlear implantation following treatment for medulloblastoma. Laryngoscope; 2010 Jan;120(1):139-43
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  • [Title] Cochlear implantation following treatment for medulloblastoma.
  • OBJECTIVES/HYPOTHESIS: Medulloblastoma is the most common pediatric malignant tumor of the central nervous system in children.
  • METHODS: Three patients treated for pediatric medulloblastoma with surgical resection, postoperative hyperfractioned craniospinal radiotherapy, and multiagent adjuvant chemotherapy who underwent cochlear implantation were identified.
  • CONCLUSIONS: Patients treated for pediatric medulloblastoma develop otologic sequelae, including profound SNHL, and may require cochlear implantation.
  • [MeSH-major] Brain Neoplasms / therapy. Cochlear Implantation. Hearing Loss, Sensorineural / surgery. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Humans. Retrospective Studies. Treatment Outcome


33. Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA: Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med; 2009 Sep 17;361(12):1173-8
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  • [Title] Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
  • Medulloblastoma is the most common malignant brain tumor in children.
  • Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma.
  • A 26-year-old man with metastatic medulloblastoma that was refractory to multiple therapies was treated with a novel hedgehog pathway inhibitor, GDC-0449; treatment resulted in rapid (although transient) regression of the tumor and reduction of symptoms.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzimidazoles / therapeutic use. Cerebellar Neoplasms / drug therapy. Hedgehog Proteins / antagonists & inhibitors. Medulloblastoma / drug therapy
  • [MeSH-minor] Adult. Anilides. Gene Expression. Humans. Male. Patched Receptors. Patched-1 Receptor. Polymerase Chain Reaction. Pyridines. RNA, Messenger / metabolism. Receptors, Cell Surface / genetics. Receptors, Cell Surface / metabolism. Signal Transduction / drug effects. Transcription Factors / genetics. Transcription Factors / metabolism. Zinc Finger Protein GLI1


34. Pierson J, Hostager B, Fan R, Vibhakar R: Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma. J Neurooncol; 2008 Oct;90(1):1-7
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  • [Title] Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma.
  • Despite recent advances in treatment medulloblastoma continues to remain a vexing problem.
  • Recently increased expression of cyclin dependent kinase 6 (CDK6) was identified as an adverse prognostic marker in medulloblastoma.
  • We hypothesized that CDK6 expression is also regulated by microRNAs in medulloblastoma.
  • We identified putative miR sites in the CDK6 including microRNA 124a, a brain enriched microRNA.
  • Expression of miR 124a was significantly decreased in medulloblastoma cells compared to normal adult cerebellum.
  • Functional association between miR 124a and CDK6 in medulloblastoma was established using luciferase assays.
  • Additionally, re-expression of miR 124a in medulloblastoma cells decreased expression of CDK6 protein.
  • Transfection of miR 124 significantly decreases medulloblastoma cell growth but does not alter apoptosis.
  • Our data strongly indicate that CDK6 is regulated by microRNA 124 in medulloblastoma and that miR 124 modulates medulloblastoma cell growth.
  • [MeSH-major] Brain Neoplasms / genetics. Cyclin-Dependent Kinase 6 / genetics. Gene Expression Regulation, Neoplastic. Medulloblastoma / genetics. MicroRNAs / genetics

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  • [Cites] RNA. 2003 Oct;9(10):1274-81 [13130141.001]
  • [Cites] Neuro Oncol. 2007 Apr;9(2):135-44 [17329407.001]
  • [Cites] Gene. 2007 Apr 15;391(1-2):39-44 [17229533.001]
  • [Cites] Neuro Oncol. 1999 Jul;1(3):232-50 [11550316.001]
  • [Cites] Cancer Cell. 2006 Jan;9(1):13-22 [16413468.001]
  • [Cites] Proc Natl Acad Sci U S A. 2006 May 2;103(18):7024-9 [16641092.001]
  • [Cites] Nature. 2005 Jun 9;435(7043):828-33 [15944707.001]
  • [Cites] J Cell Biochem. 2006 Feb 15;97(3):485-93 [16294322.001]
  • [Cites] Mol Cell. 2007 Jul 6;27(1):91-105 [17612493.001]
  • [Cites] Nature. 2005 Feb 17;433(7027):769-73 [15685193.001]
  • [Cites] Nature. 2004 Sep 16;431(7006):350-5 [15372042.001]
  • [Cites] Cell. 2007 Dec 14;131(6):1109-23 [18083101.001]
  • [Cites] Cancer Res. 2007 Feb 15;67(4):1424-9 [17308079.001]
  • [Cites] Neuron. 2005 Sep 15;47(6):779-82 [16157272.001]
  • [Cites] Nat Genet. 2005 May;37(5):495-500 [15806104.001]
  • [Cites] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14317-22 [11114185.001]
  • [Cites] Oncogene. 2007 Jul 26;26(34):5017-22 [17297439.001]
  • [Cites] Genes Dev. 2007 Apr 1;21(7):744-9 [17403776.001]
  • [Cites] Nucleic Acids Res. 2005 Mar 01;33(4):1290-7 [15741182.001]
  • [Cites] Cell Cycle. 2006 Sep;5(17):1929-35 [16929174.001]
  • [Cites] Pediatr Neurosurg. 2003 Jul;39(2):60-7 [12845195.001]
  • [Cites] Nat Struct Mol Biol. 2006 Dec;13(12 ):1097-101 [17099701.001]
  • [Cites] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2422-7 [16461918.001]
  • [Cites] Nat Genet. 2006 Sep;38(9):1060-5 [16878133.001]
  • [Cites] J Clin Oncol. 2005 Dec 1;23 (34):8853-62 [16314645.001]
  • [Cites] Development. 2005 Nov;132(21):4645-52 [16224044.001]
  • [Cites] Trends Biochem Sci. 2005 Nov;30(11):630-41 [16236519.001]
  • [Cites] Dev Dyn. 2006 Sep;235(9):2538-48 [16736490.001]
  • [Cites] Expert Rev Neurother. 2004 Sep;4(5):879-93 [15853514.001]
  • [Cites] Pediatr Blood Cancer. 2007 Dec;49(7 Suppl):1074-82 [17943961.001]
  • [Cites] Science. 2006 Apr 7;312(5770):75-9 [16484454.001]
  • [Cites] Curr Biol. 2005 Jun 21;15(12):R458-60 [15964265.001]
  • [Cites] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4 [16381832.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3697-702 [15738394.001]
  • (PMID = 18607543.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Messenger; EC 2.7.11.22 / Cyclin-Dependent Kinase 6
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35. Douglas-Akinwande AC, Payner TD, Hattab EM: Medulloblastoma mimicking Lhermitte-Duclos disease on MRI and CT. Clin Neurol Neurosurg; 2009 Jul;111(6):536-9
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  • [Title] Medulloblastoma mimicking Lhermitte-Duclos disease on MRI and CT.
  • BACKGROUND: Although previous reports purport that the unique magnetic resonance imaging (MRI) features of Lhermitte-Duclos disease (LDD) obviates the need for biopsy, medulloblastoma can have an indistinguishable imaging appearance.
  • CASE DESCRIPTION: We present a patient who suffered from a medulloblastoma that demonstrated no enhancement and had imaging characteristics that were indistinguishable from LDD.
  • [MeSH-major] Brain / pathology. Ganglioneuroma / pathology. Hamartoma Syndrome, Multiple / pathology. Infratentorial Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Adult. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / radiography. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19233547.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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36. Zitterbart K, Zavrelova I, Kadlecova J, Spesna R, Kratochvilova A, Pavelka Z, Sterba J: p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival. Acta Neuropathol; 2007 Dec;114(6):641-50
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  • [Title] p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival.
  • Recently, several TP73 transcripts have been revealed in medulloblastoma (MB), the most common malignant brain tumor in children.
  • In normal cerebellum, positive staining for p73alpha and DeltaNp73 was observed in the Purkinje cells of newborns, not adult samples, which supports the developmental role of TP73 during organogenesis of the human cerebellum.
  • Our results indicate the involvement of p73 protein in MB tumorigenesis and define TP73 as a potential prognostic and therapeutic target for medulloblastoma.
  • [MeSH-major] Brain Neoplasms / metabolism. DNA-Binding Proteins / metabolism. Medulloblastoma / metabolism. Nuclear Proteins / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Brain / metabolism. Brain / pathology. Brain / physiopathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / metabolism. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry. Male. Prognosis. Protein Isoforms / genetics. Protein Isoforms / isolation & purification. Protein Isoforms / metabolism. RNA, Messenger / analysis. RNA, Messenger / metabolism. Retrospective Studies. Survival Rate

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  • [ErratumIn] Acta Neuropathol. 2008 Nov;116(5):579-80
  • (PMID = 17912537.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Protein Isoforms; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins
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37. Gilbertson RJ, Langdon JA, Hollander A, Hernan R, Hogg TL, Gajjar A, Fuller C, Clifford SC: Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma. Eur J Cancer; 2006 Mar;42(5):646-9
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  • [Title] Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma.
  • Aberrant signalling via platelet derived growth factor receptors (PDGFRs) and the RAS/MAPK pathway has been implicated in the development of medulloblastoma, the most common malignant brain tumour in childhood.
  • To determine whether genetic mechanisms play a role in the activation of PDGFR-RAS/MAPK signalling in medulloblastoma, we performed a direct sequence analysis of the established mutational "hotspots" of known targets of activating mutations within the pathway (PDGFRA, NRAS, KRAS, HRAS and BRAF) and PDFRFB, in a cohort of 28 primary tumours.
  • A synonymous sequence variation in PDGFRA (CCG to CCA; PRO 567 PRO) was detected in two cases (approximately 7%), but not in 150 normal chromosomes assessed, suggesting that the PDGFRA locus may be associated with medulloblastoma development in certain cases.
  • These data demonstrate that activating mutations in established mutational hotspots within the PDGFR-RAS/MAPK pathway are rare events in medulloblastoma development, and suggest that alternative mechanisms are responsible for RAS/MAPK pathway activation in this disease.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Genes, ras / genetics. Medulloblastoma / genetics. Mitogen-Activated Protein Kinases / genetics. Mutation / genetics. Receptors, Platelet-Derived Growth Factor / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Exons. Female. Humans. Infant. MAP Kinase Signaling System. Male. Polymorphism, Restriction Fragment Length. Receptor, Platelet-Derived Growth Factor alpha / genetics. Receptor, Platelet-Derived Growth Factor alpha / metabolism

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  • (PMID = 16434186.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA023944; United States / NCI NIH HHS / CA / CA21765; United States / NCI NIH HHS / CA / CA96832-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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38. Yang LS, Wang YQ, Huang FP: [Correlation between the prognosis of medulloblastoma and relevant clinical factors: analysis of 73 cases]. Zhonghua Yi Xue Za Zhi; 2007 May 22;87(19):1322-5
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  • [Title] [Correlation between the prognosis of medulloblastoma and relevant clinical factors: analysis of 73 cases].
  • OBJECTIVE: To analyze the correlation between the prognosis of medulloblastoma (MB) and relevant clinical factors.
  • Those undergoing whole brain/posterior fossa plus spinal axis radiotherapy showed a better prognosis than those undergoing whole brain/posterior fossa radiotherapy.
  • [MeSH-major] Central Nervous System Neoplasms / therapy. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17727776.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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39. Mühlisch J, Bajanowski T, Rickert CH, Roggendorf W, Würthwein G, Jürgens H, Frühwald MC: Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses. J Neurooncol; 2007 May;83(1):17-29
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  • [Title] Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses.
  • Aberrant methylation is common in malignant brain tumors of childhood and may have implications for stratification and therapy.
  • Methylation of p16 (INK4A), p14 (ARF), TIMP3, CDH1, p15 (INK4B )and DAPK1 in medulloblastoma (MB) and ependymoma has been discussed controversially in the literature.
  • Therapeutic and diagnostic implications urge into depth analyses of methylation as a mechanism, which might fill some of the gaps of our understanding of brain tumor origin.
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. DNA Methylation. Genes, p16. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Tissue Inhibitor of Metalloproteinase-3 / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Apoptosis Regulatory Proteins / genetics. Calcium-Calmodulin-Dependent Protein Kinases / genetics. Child. Child, Preschool. Death-Associated Protein Kinases. Female. Gene Silencing. Humans. Infant. Male. Middle Aged. Nerve Tissue Proteins / genetics. Receptors, Immunologic / genetics

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  • [Cites] Oncogene. 2002 Feb 7;21(7):1048-61 [11850822.001]
  • [Cites] Clin Orthop Relat Res. 2006 Jan;442:216-22 [16394764.001]
  • [Cites] Oncogene. 2001 Aug 16;20(36):5033-42 [11526488.001]
  • [Cites] Int J Cancer. 2000 Jun 1;86(5):632-5 [10797283.001]
  • [Cites] Carcinogenesis. 2004 May;25(5):661-8 [14688019.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9821-6 [8790415.001]
  • [Cites] Biotechniques. 1995 Jul;19(1):116-21 [7669285.001]
  • [Cites] Cancer Res. 1999 Feb 15;59(4):798-802 [10029065.001]
  • [Cites] APMIS. 2003 Nov;111(11):1067-74 [14629273.001]
  • [Cites] Mol Cell Biol. 1993 Dec;13(12):7372-9 [7504173.001]
  • [Cites] Cancer Res. 2004 Jun 1;64(11):3871-7 [15172996.001]
  • [Cites] Cancer Res. 2004 Aug 1;64(15):5511-7 [15289362.001]
  • [Cites] Nucleic Acids Res. 2001 Nov 15;29(22):4598-606 [11713309.001]
  • [Cites] Cell. 1996 Apr 5;85(1):27-37 [8620534.001]
  • [Cites] Cancer Res. 2002 Feb 15;62(4):1148-51 [11861396.001]
  • [Cites] Biochem Biophys Res Commun. 2004 Jun 25;319(2):697-704 [15178462.001]
  • [Cites] Cancer Genet Cytogenet. 2006 Apr 1;166(1):74-81 [16616114.001]
  • [Cites] Pharmacogenomics J. 2002;2(1):7-10 [11990385.001]
  • [Cites] Methods. 2001 Dec;25(4):456-62 [11846615.001]
  • [Cites] Int J Cancer. 1999 Oct 29;83(3):309-13 [10495421.001]
  • [Cites] Anal Biochem. 2004 Oct 1;333(1):119-27 [15351288.001]
  • [Cites] Cell. 2001 Sep 7;106(5):531-4 [11551500.001]
  • [Cites] Int J Mol Med. 2003 May;11(5):655-60 [12684707.001]
  • [Cites] Mol Cell Biol. 1997 Oct;17(10):5897-904 [9315647.001]
  • [Cites] Genomics. 1999 Jun 15;58(3):254-62 [10373323.001]
  • [Cites] Oncogene. 2002 Jun 20;21(27):4345-9 [12082624.001]
  • [Cites] Mol Cell Biol. 1994 Aug;14(8):5487-94 [7518564.001]
  • [Cites] J Med Genet. 2000 Jul;37(7):501-9 [10882752.001]
  • [Cites] Cancer Res. 2001 Apr 1;61(7):2816-21 [11306450.001]
  • [Cites] Trends Genet. 2000 Jun;16(6):276-7 [10827456.001]
  • [Cites] Neurosurg Focus. 2005 Nov 15;19(5):E10 [16398460.001]
  • [Cites] Clin Cancer Res. 2006 Aug 1;12 (15):4738-46 [16899625.001]
  • [Cites] Pediatr Neurosurg. 2003 Jul;39(2):60-7 [12845195.001]
  • [Cites] Genes Chromosomes Cancer. 2001 Jan;30(1):38-47 [11107174.001]
  • [Cites] Oncogene. 2006 Feb 16;25(7):1111-7 [16186793.001]
  • [Cites] Biotechniques. 1996 Jul;21(1):126-33 [8816247.001]
  • [Cites] J Clin Oncol. 2006 Jul 20;24(21):3431-7 [16849758.001]
  • [Cites] Neuropathol Appl Neurobiol. 2003 Dec;29(6):574-83 [14636164.001]
  • [Cites] PLoS Biol. 2004 Dec;2(12):e405 [15550986.001]
  • [Cites] Pathol Oncol Res. 2004;10(1):17-21 [15029256.001]
  • [Cites] Neuropathol Appl Neurobiol. 2002 Aug;28(4):257-82 [12175339.001]
  • [Cites] Cancer Cell. 2004 Oct;6(4):387-98 [15488761.001]
  • [Cites] Cancer Genet Cytogenet. 2003 Jul 15;144(2):134-42 [12850376.001]
  • [Cites] J Pediatr Hematol Oncol. 1997 Nov-Dec;19(6):492-501 [9407934.001]
  • [Cites] Bioinformatics. 2004 Nov 22;20(17):3005-12 [15247106.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10 ):997-1003 [15758010.001]
  • [Cites] Nat Med. 2003 Apr;9(4):407-15 [12652295.001]
  • [Cites] Pediatr Blood Cancer. 2007 Apr;48(4):403-7 [16609952.001]
  • [Cites] Clin Cancer Res. 2002 Jul;8(7):2217-24 [12114423.001]
  • [Cites] Nat Genet. 2000 Feb;24(2):132-8 [10655057.001]
  • [Cites] Nature. 2001 Feb 15;409(6822):860-921 [11237011.001]
  • (PMID = 17206475.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Nerve Tissue Proteins; 0 / Receptors, Immunologic; 0 / TIMP3 protein, human; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / roundabout protein; EC 2.7.11.1 / DAPK1 protein, human; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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40. Wolff JE, Hüttermann U, Askins MA: Quantifying health status outcomes in pediatric medulloblastoma patients. Anticancer Res; 2007 Jan-Feb;27(1B):523-9
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  • [Title] Quantifying health status outcomes in pediatric medulloblastoma patients.
  • BACKGROUND: Comprehensive, efficient health status assessment tools are needed for multi-center studies examining childhood brain tumor treatment outcomes.
  • PATIENTS AND METHODS: The FMH was compared with the medical assessments, intelligence scores, and behavioral/emotional adjustment scores of 21 survivors of medulloblastoma to examine the instrument's feasibility and discriminate validity.
  • CONCLUSION: The FMH is useful as an objective, easily administered measure of health status in brain tumor patients.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Health Status. Medulloblastoma / therapy. Outcome Assessment (Health Care) / methods. Surveys and Questionnaires
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Humans. Infant. Reproducibility of Results

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  • (PMID = 17348436.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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41. Pizer BL, Clifford SC: The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials. Br J Neurosurg; 2009 Aug;23(4):364-75
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  • [Title] The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials.
  • Medulloblastoma is the most common malignant brain tumour of childhood and accounts for around 10% of all childhood cancer deaths.
  • Pan-European clinical trials being planned for medulloblastoma by the SIOP Brain tumour group will assess the stratification of patients using molecular and histological biomarkers, alongside clinical indices, to select favourable, standard and high-risk treatment groups.
  • Their success will require a coordinated approach by the entire multidisciplinary team, including neurosurgeons, oncologists and neuropathologists, with the common aim of facilitating targeted delivery of individualised risk-adapted therapies for children with medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms. Clinical Trials as Topic. Medulloblastoma. Patient Selection
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease Progression. Europe / epidemiology. Feasibility Studies. Female. Humans. Intercellular Signaling Peptides and Proteins / physiology. Male. Mutation. Prognosis. Signal Transduction. Survival Rate. Young Adult

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  • (PMID = 19637007.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins
  • [Number-of-references] 86
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42. Teglund S, Toftgård R: Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta; 2010 Apr;1805(2):181-208
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  • [Title] Hedgehog beyond medulloblastoma and basal cell carcinoma.
  • In normal adult physiology, the pathway is implicated in stem cell maintenance, tissue repair and regeneration.
  • The Hh pathway is firmly linked to the etiology of basal cell carcinoma and to at least a subset of medulloblastoma.
  • [MeSH-major] Brain Neoplasms / metabolism. Carcinoma, Basal Cell / metabolism. Hedgehog Proteins / metabolism. Medulloblastoma / metabolism. Signal Transduction / physiology. Skin Neoplasms / metabolism


43. Lueth M, von Deimling A, Pietsch T, Wong LJ, Kurtz A, Henze G, Driever PH: Medulloblastoma harbor somatic mitochondrial DNA mutations in the D-loop region. J Pediatr Hematol Oncol; 2010 Mar;32(2):156-9
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  • [Title] Medulloblastoma harbor somatic mitochondrial DNA mutations in the D-loop region.
  • Despite the growing knowledge on molecular risk factors of the most common malignant brain tumor in childhood, medulloblastoma, its biology remains only partially understood.
  • A previous study investigating the entire mitochondrial genome of medulloblastoma revealed a number of somatic mutations in tumor and corresponding cerebrospinal fluid samples.
  • In our present study we sought to corroborate these results on somatic and germ line mutations by comparing the complete mitochondrial genome sequences of medulloblastoma tissue in a further cohort of patients.
  • Analysis of the entire mitochondrial genome by temporal temperature gel electrophoresis and direct sequencing revealed 6 somatic mutations in 6 of 15 medulloblastoma.
  • These results are in support of our previous findings on frequency of somatic mitochondrial mutations in medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / genetics. DNA, Mitochondrial / genetics. Medulloblastoma / genetics. Mutation
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Genome, Mitochondrial. Humans. Infant. Male

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  • (PMID = 20147852.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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44. Chang Q, Ng HK: [Different hypermethylation status of RASSF1A in medulloblastoma and supratentorial primitive neuroectodermal tumor]. Zhonghua Bing Li Xue Za Zhi; 2007 Jan;36(1):24-8
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  • [Title] [Different hypermethylation status of RASSF1A in medulloblastoma and supratentorial primitive neuroectodermal tumor].
  • OBJECTIVE: To investigate the epigenetic involvement of RASSF1A in intracranial primitive neuroectodermal tumors (PNETs) and compare the methylation patterns between medulloblastoma (MBs) and supratentorial PNETs (SPNETs).
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. Medulloblastoma / genetics. Neuroectodermal Tumors, Primitive / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Line, Tumor. Child. Child, Preschool. DNA Methylation. Female. Gene Expression Regulation, Neoplastic. Gene Silencing. HeLa Cells. Humans. Infant. Male. Promoter Regions, Genetic / genetics. Reverse Transcriptase Polymerase Chain Reaction. Young Adult


45. Hope AJ, Mansur DB, Tu PH, Simpson JR: Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma. Childs Nerv Syst; 2006 Sep;22(9):1201-7
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  • [Title] Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma.
  • INTRODUCTION: Malignant brain tumors have been reported to occur after childhood irradiation more frequently than in the nonirradiated population.
  • DISCUSSION: In this study, we report the case of a 15-year-old boy treated for medulloblastoma with surgery and craniospinal radiotherapy, who developed a meningioma 18 years after initial treatment and subsequently an anaplastic astrocytoma 23 years after primary treatment.
  • [MeSH-major] Astrocytoma / diagnosis. Cerebellar Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Medulloblastoma / radiotherapy. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Radiotherapy Dosage. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed

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  • [Cites] J Neurosurg. 1987 Dec;67(6):915-8 [2824720.001]
  • [Cites] J Clin Oncol. 1998 Dec;16(12):3761-7 [9850019.001]
  • [Cites] J Neurosurg. 1989 Mar;70(3):469-74 [2536806.001]
  • [Cites] Ann Neurol. 1978 Oct;4(4):319-21 [727737.001]
  • [Cites] Childs Nerv Syst. 2000 Jul;16(7):390-7 [10958546.001]
  • [Cites] J Natl Cancer Inst. 2001 Apr 18;93(8):618-29 [11309438.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Aug 1;48(1):65-73 [10924973.001]
  • [Cites] Childs Nerv Syst. 2004 Apr;20(4):243-6 [14704813.001]
  • [Cites] Cancer. 1984 Feb 1;53(3):426-9 [6581853.001]
  • [Cites] Lancet. 1997 May 10;349(9062):1369 [9149706.001]
  • [Cites] J Pediatr Endocrinol Metab. 2003 Jan;16(1):97-101 [12585346.001]
  • [Cites] Surg Neurol. 2003 Jul;60(1):60-7; discussion 67 [12865017.001]
  • [Cites] Clin Neuropathol. 1994 Sep-Oct;13(5):281-5 [7805312.001]
  • [Cites] Cancer. 1998 Jan 1;82(1):8-34 [9428476.001]
  • [Cites] Pediatr Neurosurg. 1996 Oct;25(4):214-9 [9293548.001]
  • [Cites] J Neurosurg. 1998 Jan;88(1):111-5 [9420081.001]
  • [Cites] J Neurosurg. 1978 Apr;48(4):622-7 [632887.001]
  • [Cites] BMJ. 1993 Oct 23;307(6911):1030-6 [8251777.001]
  • [Cites] N Engl J Med. 1988 Oct 20;319(16):1033-9 [3173432.001]
  • [Cites] Cancer Causes Control. 1997 Nov;8(6):865-71 [9427429.001]
  • [Cites] Neurosurgery. 1995 Apr;36(4):685-90 [7596497.001]
  • [Cites] N Engl J Med. 1995 Mar 30;332(13):839-47 [7661930.001]
  • [Cites] Acta Neurochir (Wien). 2001;143(7):697-700 [11534690.001]
  • [Cites] J Neuroradiol. 1983;10 (1):43-9 [6864263.001]
  • [Cites] Neurology. 1981 May;31(5):616-9 [7194977.001]
  • [Cites] Neurosurgery. 1980 May;6(5):546-51 [6251397.001]
  • [Cites] Lancet. 1974 Feb 23;1(7852):277-9 [4130470.001]
  • [Cites] J Neurosurg. 1995 Jul;83(1):154-62 [7782835.001]
  • [Cites] Clin Neurol Neurosurg. 1998 Mar;100(1):56-9 [9637208.001]
  • [Cites] Can J Neurol Sci. 1984 Nov;11(4):475-8 [6518432.001]
  • [Cites] Arch Ophthalmol. 1988 Dec;106(12 ):1701-5 [3196211.001]
  • [Cites] Cancer. 1999 Jan 15;85(2):485-91 [10023719.001]
  • [Cites] Onkologie. 2001 Feb;24(1):66-72 [11441284.001]
  • [Cites] Eur J Paediatr Neurol. 1999;3(4):177-80 [10476368.001]
  • [Cites] Can J Neurol Sci. 1992 Nov;19(4):498-503 [1330262.001]
  • [Cites] J Neurosurg. 1978 Sep;49(3):445-9 [682008.001]
  • [Cites] Am J Public Health Nations Health. 1966 Dec;56(12):2114-20 [5334312.001]
  • [Cites] Cancer. 1979 Jan;43(1):129-36 [104784.001]
  • [Cites] J Pediatr Hematol Oncol. 2001 Oct;23(7):431-6 [11878577.001]
  • (PMID = 16570196.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 40
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46. Massimino M, Gandola L, Spreafico F, Biassoni V, Luksch R, Collini P, Solero CN, Simonetti F, Pignoli E, Cefalo G, Poggi G, Modena P, Mariani L, Potepan P, Podda M, Casanova M, Pecori E, Acerno S, Ferrari A, Terenziani M, Meazza C, Polastri D, Ravagnani F, Fossati-Bellani F: No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma. Int J Radiat Oncol Biol Phys; 2009 Apr 1;73(5):1358-63
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  • [Title] No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma.
  • PURPOSE: Myeloablative regimens were frequently used for medulloblastoma relapsing after craniospinal irradiation (CSI): in 1997-2002, we used repeated surgery, standard-dose and myeloablative chemotherapy, and reirradiation.
  • Relapse sites included leptomeninges in 9 patients, spine in 4 patients, posterior fossa in 3 patients, and brain in 1 patient.
  • A salvage therapy for medulloblastoma after CSI still needs to be sought.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms. Medulloblastoma. Neoplasm Recurrence, Local. Salvage Therapy
  • [MeSH-minor] Adolescent. Carboplatin / administration & dosage. Carboplatin / adverse effects. Child. Child, Preschool. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy / methods. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Disease-Free Survival. Drug Administration Schedule. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Granulocyte Colony-Stimulating Factor / administration & dosage. Humans. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Radiotherapy Dosage. Remission Induction / methods. Thiotepa / administration & dosage. Thiotepa / adverse effects. Vincristine / administration & dosage. Vincristine / adverse effects. Young Adult

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  • (PMID = 19019566.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; 905Z5W3GKH / Thiotepa; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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47. Kadota RP, Mahoney DH, Doyle J, Duerst R, Friedman H, Holmes E, Kun L, Zhou T, Pollack IF: Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinoma. Pediatr Blood Cancer; 2008 Nov;51(5):675-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinoma.
  • PURPOSE: To determine the response, toxicity, and survival for children with progressive or recurrent medulloblastoma and germinoma using a single myeloablative course of chemotherapy supported by autologous hematopoietic stem cells.
  • There were 6 medulloblastoma and 3 germinoma survivors with a median follow-up of 7.5 years (range = 2.8-10).
  • CONCLUSION: Myeloablative chemotherapy consisting of cyclophosphamide and melphalan was tolerable in the relapsed brain tumor setting with 19/29 cases achieving CR or CCR status and 9/29 becoming long-term survivors.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • [Cites] J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):277-81 [11464982.001]
  • [Cites] Neuro Oncol. 2003 Oct;5(4):261-7 [14565163.001]
  • [Cites] J Clin Oncol. 1996 Feb;14(2):382-8 [8636747.001]
  • [Cites] J Clin Oncol. 1997 May;15(5):1814-23 [9164190.001]
  • [Cites] Br J Cancer. 1999 Mar;79(7-8):1199-204 [10098759.001]
  • [Cites] J Neurooncol. 1999 May;43(1):43-7 [10448870.001]
  • [Cites] J Clin Oncol. 2007 Oct 10;25(29):4622-7 [17925558.001]
  • [Cites] J Neurooncol. 2005 Dec;75(3):273-8 [16195803.001]
  • [Cites] Expert Rev Neurother. 2006 May;6(5):765-79 [16734524.001]
  • [Cites] J Clin Oncol. 2006 Sep 1;24(25):4202-8 [16943538.001]
  • [Cites] Cancer. 2006 Nov 1;107(9):2291-7 [17019740.001]
  • [Cites] Pediatr Blood Cancer. 2007 Mar;48(3):285-91 [16598761.001]
  • [Cites] Cancer. 2007 Oct 1;110(7):1542-50 [17705175.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):978-86 [15758008.001]
  • (PMID = 18623206.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA098543-06; United States / NCI NIH HHS / CA / CA98543; United States / NCI NIH HHS / CA / U10 CA098413-06; United States / NCI NIH HHS / CA / U10 CA098413; United States / NCI NIH HHS / CA / U10 CA098543; None / None / / U10 CA098413-06; None / None / / U10 CA098543-06
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 8N3DW7272P / Cyclophosphamide; Q41OR9510P / Melphalan
  • [Other-IDs] NLM/ NIHMS123029; NLM/ PMC2900925
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48. Oba-Shinjo SM, Caballero OL, Jungbluth AA, Rosemberg S, Old LJ, Simpson AJ, Marie SK: Cancer-testis (CT) antigen expression in medulloblastoma. Cancer Immun; 2008;8:7
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  • [Title] Cancer-testis (CT) antigen expression in medulloblastoma.
  • Medulloblastoma is the most common childhood malignant tumor of the central nervous system.
  • Treatment of medulloblastoma requires harmful therapy and nevertheless carries a poor prognosis.
  • CT antigens, such as MAGE and NY-ESO-1, have been employed in clinical trials in various malignancies but little is known about their presence in medulloblastoma.
  • The absence of correlation between mRNA and protein expression in medulloblastoma has not been observed in other tumors and further studies addressing the biology of CT antigens are necessary to investigate the present discrepant results.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Cerebellar Neoplasms / immunology. Medulloblastoma / immunology
  • [MeSH-minor] Adult. Cancer Vaccines. Child. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Membrane Proteins / biosynthesis. Membrane Proteins / genetics. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. RNA Processing, Post-Transcriptional / genetics. RNA, Messenger / metabolism. Testis / metabolism. Testis / pathology

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  • [Cites] Annu Rev Immunol. 2006;24:175-208 [16551247.001]
  • [Cites] Int J Cancer. 2006 Feb 1;118(3):696-703 [16094643.001]
  • [Cites] Int J Oncol. 2006 May;28(5):1089-98 [16596224.001]
  • [Cites] Clin Cancer Res. 2006 Sep 15;12(18):5442-7 [17000678.001]
  • [Cites] Lancet Oncol. 2006 Oct;7(10):813-20 [17012043.001]
  • [Cites] Int J Cancer. 2007 Jan 1;120(1):67-74 [17019710.001]
  • [Cites] Cancer Biol Ther. 2006 Sep;5(9):1218-25 [16929165.001]
  • [Cites] Int J Cancer. 2007 Jan 15;120(2):337-43 [17066423.001]
  • [Cites] Childs Nerv Syst. 2007 Apr;23(4):399-405 [17119978.001]
  • [Cites] Int J Cancer. 2007 Jun 1;120(11):2411-7 [17294444.001]
  • [Cites] Int J Cancer. 2000 Mar 1;85(5):726-32 [10699956.001]
  • [Cites] Br J Cancer. 2000 Aug;83(4):493-7 [10945497.001]
  • [Cites] Clin Cancer Res. 2000 Oct;6(10):3916-22 [11051238.001]
  • [Cites] Int J Cancer. 2001 May 1;92(3):441-50 [11291084.001]
  • [Cites] Int J Cancer. 2001 Jun 15;92(6):856-60 [11351307.001]
  • [Cites] Cancer Res. 2001 Jun 15;61(12):4809-14 [11406556.001]
  • [Cites] Br J Cancer. 2001 Sep 1;85(5):713-20 [11531257.001]
  • [Cites] Cancer Res. 2001 Sep 15;61(18):6682-7 [11559535.001]
  • [Cites] Int J Cancer. 2002 Jun 20;99(6):839-45 [12115486.001]
  • [Cites] Cancer Biol Ther. 2002 Jul-Aug;1(4):380-7 [12432251.001]
  • [Cites] In Vivo. 2002 Nov-Dec;16(6):583-8 [12494904.001]
  • [Cites] Clin Cancer Res. 2003 Jan;9(1):167-73 [12538465.001]
  • [Cites] Cancer Immun. 2001 Mar 30;1:1 [12747762.001]
  • [Cites] Cancer Immun. 2002 Sep 19;2:11 [12747756.001]
  • [Cites] Lab Invest. 2003 Aug;83(8):1185-92 [12920247.001]
  • [Cites] Brain Pathol. 2003 Jul;13(3):376-85 [12946027.001]
  • [Cites] Cancer Immun. 2004 Jan 23;4:1 [14738373.001]
  • [Cites] Int J Cancer. 2004 Apr 20;109(4):568-75 [14991579.001]
  • [Cites] Int J Cancer. 2004 May 1;109(5):698-702 [14999777.001]
  • [Cites] Cancer Res. 2004 Jul 15;64(14):4980-6 [15256472.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10697-702 [15252201.001]
  • [Cites] Science. 1991 Dec 13;254(5038):1643-7 [1840703.001]
  • [Cites] Int J Cancer. 1993 May 28;54(3):527-8 [8509230.001]
  • [Cites] Int J Cancer. 1995 Nov 3;63(3):375-80 [7591235.001]
  • [Cites] Int J Cancer. 1996 Oct 21;69(5):403-7 [8900375.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1914-8 [9050879.001]
  • [Cites] Am J Pathol. 1997 Jun;150(6):2143-52 [9176405.001]
  • [Cites] Cancer Res. 1998 Feb 15;58(4):743-52 [9485030.001]
  • [Cites] Nat Med. 1998 Mar;4(3):321-7 [9500606.001]
  • [Cites] Nat Med. 1998 Mar;4(3):328-32 [9500607.001]
  • [Cites] Childs Nerv Syst. 1998 Jun;14(6):256-62 [9694337.001]
  • [Cites] Int J Cancer. 1999 Jan 18;80(2):219-30 [9935203.001]
  • [Cites] Clin Cancer Res. 1999 Feb;5(2):335-41 [10037183.001]
  • [Cites] Cancer Immun. 2004 Nov 17;4:13 [15546177.001]
  • [Cites] Mod Pathol. 2005 Jan;18(1):119-26 [15272278.001]
  • [Cites] Neurosci Lett. 2005 Jun 10-17;381(1-2):69-73 [15882792.001]
  • [Cites] Nat Rev Cancer. 2005 Aug;5(8):615-25 [16034368.001]
  • [Cites] Clin Cancer Res. 2005 Nov 15;11(22):8055-62 [16299236.001]
  • [Cites] Cancer Immun. 2006;6:7 [16594646.001]
  • (PMID = 18426187.001).
  • [ISSN] 1424-9634
  • [Journal-full-title] Cancer immunity
  • [ISO-abbreviation] Cancer Immun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / Cancer Vaccines; 0 / MAGEA3 protein, human; 0 / MAGEC1 protein, human; 0 / MAGEC2 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2935780
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49. Kool M, Koster J, Bunt J, Hasselt NE, Lakeman A, van Sluis P, Troost D, Meeteren NS, Caron HN, Cloos J, Mrsić A, Ylstra B, Grajkowska W, Hartmann W, Pietsch T, Ellison D, Clifford SC, Versteeg R: Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One; 2008;3(8):e3088
The Lens. Cited by Patents in .

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  • [Title] Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
  • BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children.
  • This illustrates the potential benefits of a robust classification of medulloblastoma patients and a detailed knowledge of associated biological mechanisms.
  • METHODS AND FINDINGS: To get a better insight into the molecular biology of medulloblastoma we established mRNA expression profiles of 62 medulloblastomas and analyzed 52 of them also by comparative genomic hybridization (CGH) arrays.
  • Monosomy of chromosome 6 occurred only in type A tumors, loss of 9q mostly occurred in type B tumors, whereas chromosome 17 aberrations, most common in medulloblastoma, were strongly associated with type C or D tumors.
  • CONCLUSIONS: The new medulloblastoma classification presented in this study will greatly enhance the understanding of this heterogeneous disease.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Gene Expression Profiling. Genomics. Medulloblastoma / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA Mutational Analysis. DNA, Neoplasm / genetics. Female. Humans. Male. Nucleic Acid Hybridization. RNA, Neoplasm / genetics. Signal Transduction. Transforming Growth Factor beta / physiology

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  • [Cites] Cancer Res. 1997 Jul 1;57(13):2581-5 [9205058.001]
  • [Cites] Cancer Res. 1998 Mar 1;58(5):896-9 [9500446.001]
  • [Cites] Clin Cancer Res. 2007 May 1;13(9):2651-7 [17473196.001]
  • [Cites] Cancer Res. 2007 May 1;67(9):4005-9 [17483310.001]
  • [Cites] Cancer Res. 1997 Mar 1;57(5):842-5 [9041183.001]
  • [Cites] Cancer Res. 1997 Jun 1;57(11):2085-8 [9187099.001]
  • [Cites] J Neurosurg. 1999 Dec;91(6):971-7 [10584843.001]
  • [Cites] Am J Pathol. 2000 Feb;156(2):433-7 [10666372.001]
  • [Cites] J Neuropathol Exp Neurol. 2000 Apr;59(4):333-7 [10759189.001]
  • [Cites] Genes Dev. 2000 Apr 15;14(8):994-1004 [10783170.001]
  • [Cites] J Neurosurg. 2000 Sep;93(3):437-48 [10969942.001]
  • [Cites] Klin Padiatr. 2000 Jul-Aug;212(4):196-9 [10994550.001]
  • [Cites] Int J Cancer. 2000 Sep 20;89(5):395-402 [11008200.001]
  • [Cites] Physiol Genomics. 1999 Aug 31;1(2):83-91 [11015565.001]
  • [Cites] Int J Cancer. 2001 Aug 1;93(3):445-9 [11433413.001]
  • [Cites] Surv Ophthalmol. 1998 Jul-Aug;43(1):59-70 [9716194.001]
  • [Cites] J Neurooncol. 2004 Nov;70(2):203-15 [15674478.001]
  • [Cites] Cancer Res. 2005 Feb 1;65(3):703-7 [15705863.001]
  • [Cites] Cancer Res. 2005 Feb 1;65(3):919-24 [15705891.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):978-86 [15758008.001]
  • [Cites] Clin Cancer Res. 2005 Jul 1;11(13):4707-16 [16000565.001]
  • [Cites] Clin Cancer Res. 2005 Jul 1;11(13):4733-40 [16000568.001]
  • [Cites] BMC Bioinformatics. 2005;6:144 [15941488.001]
  • [Cites] J Clin Oncol. 2005 Nov 1;23(31):7951-7 [16258095.001]
  • [Cites] Nucleic Acids Res. 2005;33(22):e192 [16361265.001]
  • [Cites] Genes Chromosomes Cancer. 2006 Mar;45(3):290-303 [16320246.001]
  • [Cites] J Neuropathol Exp Neurol. 2006 Feb;65(2):176-86 [16462208.001]
  • [Cites] Eur J Cancer. 2006 Mar;42(5):646-9 [16434186.001]
  • [Cites] J Clin Oncol. 2006 Apr 20;24(12):1924-31 [16567768.001]
  • [Cites] J Neuropathol Exp Neurol. 2006 Jun;65(6):549-61 [16783165.001]
  • [Cites] Oncogene. 2006 Aug 28;25(38):5277-85 [16936748.001]
  • [Cites] Lancet Oncol. 2006 Oct;7(10):813-20 [17012043.001]
  • [Cites] Cell Cycle. 2006 Nov;5(22):2666-70 [17172831.001]
  • [Cites] Brain Pathol. 2007 Apr;17(2):151-64 [17388946.001]
  • [Cites] Bioinformatics. 2007 Apr 1;23(7):892-4 [17267432.001]
  • [Cites] Clin Cancer Res. 2001 Aug;7(8):2425-33 [11489822.001]
  • [Cites] Br J Cancer. 2001 Sep 1;85(5):705-12 [11531256.001]
  • [Cites] Cancer Res. 2001 Oct 1;61(19):7039-43 [11585731.001]
  • [Cites] Nat Genet. 2001 Oct;29(2):143-52 [11544480.001]
  • [Cites] J Neurosurg. 2001 Nov;95(5):871-8 [11702879.001]
  • [Cites] Nature. 2002 Jan 24;415(6870):436-42 [11807556.001]
  • [Cites] Cancer. 2002 Jan 15;94(2):552-60 [11900240.001]
  • [Cites] Arch Pathol Lab Med. 2002 May;126(5):540-4 [11958658.001]
  • [Cites] J Pediatr Hematol Oncol. 2002 Mar-Apr;24(3):205-10 [11990307.001]
  • [Cites] Nat Genet. 2002 Jul;31(3):306-10 [12068298.001]
  • [Cites] Int J Cancer. 2002 Sep 10;101(2):198-201 [12209999.001]
  • [Cites] Biotechniques. 2003 Feb;34(2):374-8 [12613259.001]
  • [Cites] Oncogene. 2003 Oct 23;22(48):7687-94 [14576832.001]
  • [Cites] Nat Genet. 2003 Nov;35(3):197-8 [14593398.001]
  • [Cites] Oncol Rep. 2004 Aug;12(2):275-80 [15254688.001]
  • [Cites] Clin Cancer Res. 2004 Aug 15;10(16):5482-93 [15328187.001]
  • [Cites] Invest Ophthalmol Vis Sci. 1985 Apr;26(4):568-71 [4074467.001]
  • [Cites] Arch Ophthalmol. 1986 Jan;104(1):111-3 [3942531.001]
  • [Cites] Acta Neuropathol. 1986;69(1-2):165-7 [3515828.001]
  • [Cites] Acta Neuropathol. 1986;71(3-4):224-7 [3541480.001]
  • [Cites] Cancer. 1987 Oct 15;60(8):1763-6 [2958128.001]
  • [Cites] Acta Neuropathol. 1988;76(2):204-7 [3407397.001]
  • [Cites] Acta Neuropathol. 1989;78(6):629-36 [2816305.001]
  • [Cites] Oncogene. 1990 Feb;5(2):225-32 [2157185.001]
  • [Cites] J Neuropathol Exp Neurol. 1990 Jul;49(4):424-37 [2141872.001]
  • [Cites] Tumori. 1991 Apr 30;77(2):118-21 [2048223.001]
  • [Cites] Med Pediatr Oncol. 1991;19(4):240-5 [2056968.001]
  • [Cites] Acta Neuropathol. 1991;81(3):296-302 [2058365.001]
  • [Cites] Acta Neuropathol. 1992;83(5):482-7 [1377856.001]
  • [Cites] Br J Cancer. 1995 Mar;71(3):473-7 [7880726.001]
  • [Cites] J Neuropathol Exp Neurol. 1995 Sep;54(5):664-72 [7666055.001]
  • (PMID = 18769486.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Neoplasm; 0 / Transforming Growth Factor beta
  • [Other-IDs] NLM/ PMC2518524
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50. Riazmontazer N, Daneshbod Y: Cytology of desmoplastic medulloblastoma in imprint smears: a report of 2 cases. Acta Cytol; 2006 Jan-Feb;50(1):97-100
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  • [Title] Cytology of desmoplastic medulloblastoma in imprint smears: a report of 2 cases.
  • BACKGROUND: Desmoplastic medulloblastoma is a rare subtype of medulloblastoma with astroglial differentiation.
  • The cytomorphologic features in intraoperative imprint smears from 2 cases of desmoplastic medulloblastoma are described.
  • The cytology was misinterpreted as glial tumors, while the final histologic diagnosis in both cases were desmoplastic medulloblastoma.
  • CONCLUSION: Desmoplastic medulloblastoma shows distinctive cytology in intraoperative smears.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis
  • [MeSH-minor] Adult. Astrocytes / pathology. Brain Neoplasms / diagnosis. Diagnostic Errors. Female. Glioma / diagnosis. Humans. Intraoperative Period. Male. Neurons / pathology

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  • (PMID = 16514849.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Scott DK, Straughton D, Cole M, Bailey S, Ellison DW, Clifford SC: Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma. Cell Cycle; 2006 Oct;5(20):2381-9
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  • [Title] Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma.
  • Abnormalities of chromosome 10 are frequently observed in the development of medulloblastoma, the most common malignant brain tumor of childhood.
  • This region contains three genes, MXI1, SUFU and BTRC, which represent putative medulloblastoma tumor suppressor (TS) genes on the basis of either (i) negative regulation of critical medulloblastoma pathways, or (ii) mutation in other cancer types.
  • These findings implicate the inactivation of critical TS loci at 10q23.3-25.3 in medulloblastoma, however comprehensive analysis of SUFU, BTRC and MXI1 indicates they are unlikely to represent major targets of these allelic losses.
  • MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma.
  • [MeSH-major] Basic Helix-Loop-Helix Transcription Factors / genetics. Chromosomes, Human, Pair 10. Genes, Tumor Suppressor. Medulloblastoma / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA Mutational Analysis. Female. Gene Silencing. Humans. Infant. Male. Physical Chromosome Mapping. Repressor Proteins / genetics. beta-Transducin Repeat-Containing Proteins / genetics

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  • (PMID = 17102621.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BTRC protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / MXI1 protein, human; 0 / Repressor Proteins; 0 / SUFU protein, human; 0 / Tumor Suppressor Proteins; 0 / beta-Transducin Repeat-Containing Proteins
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52. Gururangan S, Krauser J, Watral MA, Driscoll T, Larrier N, Reardon DA, Rich JN, Quinn JA, Vredenburgh JJ, Desjardins A, McLendon RE, Fuchs H, Kurtzberg J, Friedman HS: Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. Neuro Oncol; 2008 Oct;10(5):745-51
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  • [Title] Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma.
  • The efficacy of high-dose chemotherapy (HDC) or standard salvage therapy was evaluated in patients with recurrent medulloblastoma (MBL) using retrospective chart review of all patients with recurrent MBL treated at Duke University Medical Center between 1995 and 2005 and who had undergone HDC with or without radiotherapy (RT) or standard salvage therapy after relapse.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cerebellar Neoplasms / drug therapy. Medulloblastoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Salvage Therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Humans. Kaplan-Meier Estimate. Retrospective Studies

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  • [Cites] J Clin Oncol. 1999 Dec;17(12):3720-8 [10577843.001]
  • [Cites] Cancer. 2008 Mar 15;112(6):1345-53 [18224664.001]
  • [Cites] Neuro Oncol. 1999 Apr;1(2):152-61 [11554387.001]
  • [Cites] Lancet Oncol. 2004 Apr;5(4):209-18 [15050952.001]
  • [Cites] Neurology. 1986 May;36(5):597-601 [3703257.001]
  • [Cites] Cancer Res. 1988 Nov 15;48(22):6417-23 [3180059.001]
  • [Cites] J Neurosurg. 1991 Oct;75(4):575-82 [1885975.001]
  • [Cites] N Engl J Med. 1994 Mar 31;330(13):892-5 [8114859.001]
  • [Cites] J Clin Oncol. 1996 Feb;14(2):382-8 [8636747.001]
  • [Cites] J Neurooncol. 1996 Jan;27(1):87-98 [8699230.001]
  • [Cites] J Clin Oncol. 1996 Jun;14(6):1922-7 [8656261.001]
  • [Cites] J Clin Oncol. 1997 May;15(5):1814-23 [9164190.001]
  • [Cites] J Clin Oncol. 1998 Jan;16(1):222-8 [9440746.001]
  • [Cites] J Clin Oncol. 1998 Jul;16(7):2486-93 [9667268.001]
  • [Cites] J Clin Oncol. 2006 Sep 1;24(25):4202-8 [16943538.001]
  • [Cites] Eur J Cancer. 2006 Sep;42(14):2335-42 [16899365.001]
  • [Cites] Lancet Oncol. 2006 Oct;7(10):813-20 [17012043.001]
  • [Cites] J Neurosurg. 2007 Jul;107(1 Suppl):5-10 [17644914.001]
  • [Cites] J Clin Oncol. 2000 Aug;18(16):2935-7 [10944125.001]
  • (PMID = 18755919.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2666251
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53. Nakahara Y, Northcott PA, Li M, Kongkham PN, Smith C, Yan H, Croul S, Ra YS, Eberhart C, Huang A, Bigner D, Grajkowska W, Van Meter T, Rutka JT, Taylor MD: Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. Neoplasia; 2010 Jan;12(1):20-7
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  • [Title] Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.
  • Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown.
  • We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution single nucleotide polymorphism arrays, digital karyotyping, and genomic real-time polymerase chain reaction (PCR).
  • Medulloblastoma cell lines drastically increase the expression of KLF4 in response to the demethylating agent 5-azacytidine and demonstrate dense methylation of the promoter CpG island by bisulfite sequencing.
  • Reexpression of KLF4 in the D283 medulloblastoma cell line results in significant growth suppression both in vitro and in vivo.
  • We conclude that KLF4 is inactivated by either genetic or epigenetic mechanisms in a large subset of medulloblastomas and that it likely functions as a tumor suppressor gene in the pathogenesis of medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Epigenesis, Genetic. Kruppel-Like Transcription Factors / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adult. Animals. Antimetabolites, Antineoplastic / pharmacology. Azacitidine / pharmacology. Cell Line, Tumor. CpG Islands / genetics. DNA Methylation / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Gene Expression Regulation, Neoplastic / genetics. Humans. Kaplan-Meier Estimate. Loss of Heterozygosity. Mice. Mice, Nude. Neoplasms, Experimental / genetics. Neoplasms, Experimental / pathology. Oligonucleotide Array Sequence Analysis. Polymorphism, Single Nucleotide. Promoter Regions, Genetic / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transplantation, Heterologous

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  • [Cites] Neuron. 2001 Aug 30;31(4):557-68 [11545715.001]
  • [Cites] Cancer Res. 2009 Apr 15;69(8):3249-55 [19351822.001]
  • [Cites] Oncogene. 2004 Jan 15;23(2):395-402 [14724568.001]
  • [Cites] Clin Cancer Res. 2004 Apr 15;10(8):2709-19 [15102675.001]
  • [Cites] Oncogene. 2004 Apr 22;23(19):3444-53 [15064731.001]
  • [Cites] Neoplasia. 2004 Mar-Apr;6(2):168-78 [15140406.001]
  • [Cites] Oncogene. 2004 Jun 3;23(26):4577-83 [15077159.001]
  • [Cites] Neoplasia. 2004 Jul-Aug;6(4):310-22 [15256053.001]
  • [Cites] Cancer Res. 2004 Sep 1;64(17):6002-9 [15342380.001]
  • [Cites] Development. 1999 May;126(9):1927-35 [10101126.001]
  • [Cites] Cancer Res. 2004 Nov 1;64(21):7787-93 [15520184.001]
  • [Cites] Cancer Res. 2005 Feb 1;65(3):919-24 [15705891.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4542-7 [15761058.001]
  • [Cites] Cancer Res. 2005 Apr 1;65(7):2746-54 [15805274.001]
  • [Cites] Neoplasia. 2005 Jun;7(6):575-84 [16036108.001]
  • [Cites] Nat Cell Biol. 2005 Nov;7(11):1074-82 [16244670.001]
  • [Cites] Nat Rev Cancer. 2006 Jan;6(1):11-23 [16372018.001]
  • [Cites] J Clin Oncol. 2006 Apr 20;24(12):1924-31 [16567768.001]
  • [Cites] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11579-83 [16864777.001]
  • [Cites] Lancet Oncol. 2006 Oct;7(10):813-20 [17012043.001]
  • [Cites] Childs Nerv Syst. 2006 Nov;22(11):1379-94 [16951964.001]
  • [Cites] Br J Cancer. 2007 Jul 16;97(2):267-74 [17579622.001]
  • [Cites] Cancer Res. 2007 Aug 1;67(15):7147-54 [17671182.001]
  • [Cites] J Immunol. 2007 Oct 1;179(7):4679-84 [17878366.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14935-40 [17846424.001]
  • [Cites] Neoplasia. 2008 Jan;10(1):89-98 [18231642.001]
  • [Cites] Cancer Res. 2008 Jun 15;68(12):4631-9 [18559508.001]
  • [Cites] Neoplasia. 2008 Jul;10(7):736-44 [18592012.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16224-9 [18852474.001]
  • [Cites] Cancer Res. 2008 Dec 1;68(23):9945-53 [19047176.001]
  • [Cites] Neoplasia. 2008 Dec;10(12):1343-9, 5p following 1349 [19048113.001]
  • [Cites] Neuro Oncol. 2008 Dec;10(6):981-94 [18664619.001]
  • [Cites] Neoplasia. 2009 Jan;11(1):96-101 [19107236.001]
  • [Cites] Mol Cancer Res. 2009 Jan;7(1):33-40 [19147535.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G490-8 [19109406.001]
  • [Cites] Nat Genet. 2009 Apr;41(4):465-72 [19270706.001]
  • [Cites] Nature. 2009 Apr 9;458(7239):719-24 [19360079.001]
  • [Cites] Neoplasia. 2003 May-Jun;5(3):198-204 [12869303.001]
  • (PMID = 20072650.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS055089
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / GKLF protein; 0 / Kruppel-Like Transcription Factors; M801H13NRU / Azacitidine
  • [Other-IDs] NLM/ PMC2805880
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54. Khalil EM: Treatment results of adults and children with medulloblastoma NCI, Cairo University experience. J Egypt Natl Canc Inst; 2008 Jun;20(2):175-86
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  • [Title] Treatment results of adults and children with medulloblastoma NCI, Cairo University experience.
  • PURPOSE: To evaluate treatment outcome and prognostic factors of adults and pediatric medulloblastoma patients treated by adjuvant postoperative craniospinal irradiation (CSI) and chemotherapy.
  • PATIENTS AND METHODS: Between 1997 and 2004, 67 patients were treated in the National cancer Institute- Cairo University; 51 pediatric patients with a median age of 7 years and 16 adult patients with a median age of 25 years.
  • All patients were treated by craniospinal radiotherapy (RT); with a median dose of 34Gy to the whole brain, 54Gy to the posterior fossa and 32Gy to the spinal axis.
  • The median interval between surgery and RT was 45 days and 38 days for the pediatric and adult groups respectively.
  • The median duration of RT was 54 days and 52 days for pediatric and adult patients respectively.
  • RESULTS: For the pediatric and adult patients, the 5- and 7-year overall and disease-free survival rates were 89% & 78% vs. 84% & 56% and 80% & 68% vs. 79% & 52% respectively.
  • Ninety percent (9/10) of the pediatric relapses were of the high risk group (8 received no chemotherapy) and took place within 2 years; similarly all adult relapses were of the high risk group; three relapses took place after 2 years.
  • For adult patients; only the risk category was a significant prognostic factor with 5-year disease-free survival rate of 100% vs. 40% for low and high risk respectively (p=0.03).
  • CONCLUSION: Survival rates of medulloblastoma pediatric patients were better than the adult ones.
  • Late relapses, lateral tumor location and shorter median follow up were noted in adult patients.
  • In addition, high risk category was shown to be a prognostic factor for both pediatric and adult patients.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cerebellar Neoplasms / therapy. Cranial Irradiation. Medulloblastoma / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20029474.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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55. Hamasaki K, Nakamura H, Ueda Y, Makino K, Kuratsu J: Radiation-induced glioblastoma occurring 35 years after radiation therapy for medulloblastoma: case report. Brain Tumor Pathol; 2010 Apr;27(1):39-43
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  • [Title] Radiation-induced glioblastoma occurring 35 years after radiation therapy for medulloblastoma: case report.
  • Histological diagnosis was medulloblastoma (MB).
  • Postoperatively he received a total of 40 Gy radiation to the whole brain and 30.5 Gy to the spine without chemotherapy.
  • [MeSH-major] Cerebellar Neoplasms / therapy. Glioblastoma / etiology. Glioblastoma / therapy. Medulloblastoma / radiotherapy. Neoplasms, Second Primary. Radiotherapy / adverse effects
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Male. Neurosurgical Procedures. Nimustine / administration & dosage. Procarbazine / administration & dosage. Time Factors. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 20425047.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0S726V972K / Nimustine; 35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine
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56. Yüksel M, Lutterbey G, Biersack HJ, Elke U, Hasan C, Gao Z, Bode U, Ezziddin S: 111In-pentetreotide scintigraphy in medulloblastoma: a comparison with magnetic resonance imaging. Acta Oncol; 2007;46(1):111-7
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  • [Title] 111In-pentetreotide scintigraphy in medulloblastoma: a comparison with magnetic resonance imaging.
  • Medulloblastoma (MB) is a primitive neuroectodermal tumour constituting a grade IV brain malignancy.
  • MRI remains the first step imaging technique in medulloblastoma patients before and after surgery and during the follow-up providing the highest sensitivity.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Magnetic Resonance Imaging. Medulloblastoma / diagnosis. Somatostatin / analogs & derivatives
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Predictive Value of Tests. Receptors, Somatostatin. Sensitivity and Specificity. Tomography, Emission-Computed, Single-Photon. Whole Body Imaging

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  • (PMID = 17438713.001).
  • [ISSN] 0284-186X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Receptors, Somatostatin; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide
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57. Lindsey JC, Lusher ME, Anderton JA, Gilbertson RJ, Ellison DW, Clifford SC: Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma. Br J Cancer; 2007 Jul 16;97(2):267-74
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  • [Title] Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma.
  • Using a pharmacological expression reactivation approach, we screened 16 S100 genes for evidence of epigenetic regulation in medulloblastoma, the most common malignant brain tumour of childhood.
  • Four family members (S100A2, S100A4, S100A6 and S100A10) demonstrated evidence of upregulated expression in multiple medulloblastoma cell lines, following treatment with the DNA methyltransferase inhibitor, 5'-aza-2'-deoxycytidine.
  • Assessed against these normal tissue-specific methylation states, S100A6 and S100A10 demonstrated tumour-specific hypermethylation in medulloblastoma primary tumours (5 out of 40 and 4 out of 35, respectively, both 12%) and cell lines (both 7 out of 9, 78%), which was associated with their transcriptional silencing.
  • In summary, these data characterise complex patterns of somatic methylation affecting S100 genes in the normal cerebellum and demonstrate their disruption causing epigenetic deregulation of multiple S100 family members in medulloblastoma development.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Epigenesis, Genetic. Gene Expression Regulation, Neoplastic. Medulloblastoma / genetics. S100 Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Azacitidine / analogs & derivatives. Azacitidine / pharmacology. Cell Line, Tumor. Cerebellum / metabolism. Child. Child, Preschool. DNA Methylation. DNA Modification Methylases / antagonists & inhibitors. Female. Humans. Infant. Male

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  • [Cites] Acta Neurobiol Exp (Wars). 2000;60(4):569-75 [11200185.001]
  • [Cites] Nat Genet. 2006 May;38(5):540-9 [16642018.001]
  • [Cites] Am J Pathol. 2002 Jan;160(1):45-50 [11786397.001]
  • [Cites] Front Biosci. 2002 May 1;7:d1356-68 [11991838.001]
  • [Cites] Expert Opin Investig Drugs. 2002 Jun;11(6):747-54 [12036419.001]
  • [Cites] Oncogene. 2002 Aug 12;21(35):5400-13 [12154403.001]
  • [Cites] Cancer Res. 2002 Oct 15;62(20):5906-11 [12384556.001]
  • [Cites] Bioinformatics. 2002 Nov;18(11):1427-31 [12424112.001]
  • [Cites] Cancer Res. 2003 Jan 1;63(1):140-8 [12517790.001]
  • [Cites] FASEB J. 2003 Feb;17(2):235-46 [12554702.001]
  • [Cites] Microsc Res Tech. 2003 Apr 15;60(6):540-51 [12645002.001]
  • [Cites] Gene. 2003 May 22;310:133-42 [12801640.001]
  • [Cites] J Neuropathol Exp Neurol. 2003 Jun;62(6):627-32 [12834107.001]
  • [Cites] J Biol Chem. 2004 Jan 16;279(3):2053-62 [14570893.001]
  • [Cites] Oncogene. 2004 Feb 26;23(8):1531-8 [14716296.001]
  • [Cites] Carcinogenesis. 2004 May;25(5):661-8 [14688019.001]
  • [Cites] Biochem Cell Biol. 2004 Aug;82(4):508-15 [15284904.001]
  • [Cites] Biochem J. 2006 Jun 1;396(2):201-14 [16683912.001]
  • [Cites] Br J Cancer. 2004 Aug 16;91(4):739-44 [15280928.001]
  • [Cites] FEBS Lett. 2004 Aug 13;572(1-3):184-8 [15304345.001]
  • [Cites] Biochem Biophys Res Commun. 2004 Oct 1;322(4):1111-22 [15336958.001]
  • [Cites] Biochem Soc Trans. 2004 Dec;32(Pt 6):913-5 [15506922.001]
  • [Cites] Proc Natl Acad Sci U S A. 1990 Aug;87(16):6117-21 [2385586.001]
  • [Cites] Cancer Res. 1992 Jan 1;52(1):108-16 [1727369.001]
  • [Cites] Neuroreport. 1993 Apr;4(4):383-6 [8499593.001]
  • [Cites] Nucleic Acids Res. 1997 Jun 15;25(12):2532-4 [9171110.001]
  • [Cites] Cell Calcium. 1997 Oct;22(4):243-54 [9481475.001]
  • [Cites] Clin Exp Metastasis. 1998 Jul;16(5):471-9 [10091942.001]
  • [Cites] Cancer Res. 2005 Jan 1;65(1):26-33 [15665276.001]
  • [Cites] Br J Cancer. 2005 Jun 6;92(11):1955-8 [15900299.001]
  • [Cites] Clin Cancer Res. 2005 Aug 1;11(15):5356-64 [16061848.001]
  • [Cites] Cell Mol Biol (Noisy-le-grand). 2005 Sep 5;51(2):201-14 [16171556.001]
  • [Cites] Prostate. 2005 Dec 1;65(4):322-30 [16015609.001]
  • [Cites] Genes Chromosomes Cancer. 2006 Jan;45(1):47-60 [16149064.001]
  • [Cites] J Pediatr. 2005 Dec;147(6):731-8 [16356421.001]
  • [Cites] Neurosurg Focus. 2005 Nov;19(5):E10 [16398460.001]
  • [Cites] J Biol Chem. 2006 Jan 13;281(2):677-80 [16243835.001]
  • [Cites] Cancer Res. 2006 Jan 15;66(2):1199-207 [16424059.001]
  • [Cites] Cancer Res. 2001 Nov 1;61(21):7999-8004 [11691825.001]
  • (PMID = 17579622.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / S100 Proteins; 776B62CQ27 / decitabine; EC 2.1.1.- / DNA Modification Methylases; M801H13NRU / Azacitidine
  • [Other-IDs] NLM/ PMC2360310
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58. Eberhart CG, Chaudhry A, Daniel RW, Khaki L, Shah KV, Gravitt PE: Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus. BMC Cancer; 2005 Feb 17;5:19
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  • [Title] Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus.
  • BACKGROUND: p53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes.
  • We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors.
  • JC viral sequences were analyzed in DNA extracted from 33 frozen medulloblastoma and PNET samples using quantitative polymerase chain reaction.
  • The increased p53 immunoreactivity in anaplastic medulloblastoma, ATRT, and sPNET was statistically significant.
  • No JC virus was identified in the embryonal brain tumor samples, while an endogenous human retrovirus (ERV-3) was readily detected.

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  • [Cites] Brain Pathol. 2000 Jan;10(1):85-92 [10668898.001]
  • [Cites] J Neurooncol. 1999;45(2):103-10 [10778725.001]
  • [Cites] Genes Dev. 2000 Apr 15;14(8):994-1004 [10783170.001]
  • [Cites] Clin Cancer Res. 2000 Jul;6(7):2759-63 [10914721.001]
  • [Cites] Cancer Res. 2001 Jan 15;61(2):513-6 [11212243.001]
  • [Cites] J Virol Methods. 2001 Feb;91(2):109-17 [11164492.001]
  • [Cites] Neuropathology. 2001 Jun;21(2):129-37 [11396678.001]
  • [Cites] J Cancer Res Clin Oncol. 2001;127(6):351-8 [11414195.001]
  • [Cites] J Neurooncol. 2001 Mar;52(1):57-62 [11451203.001]
  • [Cites] Nature. 2002 Jan 24;415(6870):436-42 [11807556.001]
  • [Cites] J Natl Cancer Inst. 2002 Feb 20;94(4):267-73 [11854388.001]
  • [Cites] Cancer. 2002 Jan 15;94(2):552-60 [11900240.001]
  • [Cites] Neuro Oncol. 2002 Apr;4(2):115-22 [11916503.001]
  • [Cites] Br J Cancer. 2002 Apr 8;86(7):1117-23 [11953859.001]
  • [Cites] Neuro Oncol. 2002 Jul;4(3):165-70 [12084346.001]
  • [Cites] Neuropathol Appl Neurobiol. 2002 Aug;28(4):325-33 [12175345.001]
  • [Cites] J Neurooncol. 2002 Aug;59(1):49-61 [12222838.001]
  • [Cites] Cancer Res. 1991 Sep 1;51(17):4721-3 [1873817.001]
  • [Cites] Oncogene. 1992 Jun;7(6):1159-66 [1594246.001]
  • [Cites] Annu Rev Biochem. 1992;61:55-85 [1323237.001]
  • [Cites] Am J Surg Pathol. 1992 Jul;16(7):687-93 [1530108.001]
  • [Cites] Br J Cancer. 1993 Oct;68(4):801-7 [8398711.001]
  • [Cites] Diagn Mol Pathol. 1993 Mar;2(1):23-8 [8287222.001]
  • [Cites] Cancer Res. 1994 Nov 1;54(21):5649-51 [7923211.001]
  • [Cites] Hum Pathol. 1994 Dec;25(12):1341-5 [8001929.001]
  • [Cites] Am J Pathol. 1984 Sep;116(3):455-63 [6089567.001]
  • [Cites] J Natl Cancer Inst. 1987 Sep;79(3):585-91 [3041095.001]
  • [Cites] J Clin Microbiol. 1989 Jun;27(6):1174-9 [2546971.001]
  • [Cites] Acta Neuropathol. 1994;88(5):465-71 [7847076.001]
  • [Cites] Cancer Lett. 1996 Jun 24;104(1):103-13 [8640736.001]
  • [Cites] Cancer Genet Cytogenet. 1998 May;103(1):1-6 [9595036.001]
  • [Cites] Anticancer Res. 1998 Mar-Apr;18(2A):849-53 [9615731.001]
  • [Cites] Nat Med. 1998 Jul;4(7):844-7 [9662379.001]
  • [Cites] J Infect Dis. 1998 Dec;178(6):1816-20 [9815242.001]
  • [Cites] Oncogene. 1999 Jan 7;18(1):39-46 [9926918.001]
  • [Cites] Cancer. 1999 Jul 15;86(2):331-9 [10421270.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11519-24 [10500209.001]
  • [Cites] Clin Cancer Res. 2004 Nov 15;10(22):7613-20 [15569993.001]
  • [Cites] Int J Cancer. 2005 Feb 20;113(5):769-74 [15499616.001]
  • [Cites] Childs Nerv Syst. 2002 Oct;18(9-10):485-91 [12382173.001]
  • [Cites] J Neuropathol Exp Neurol. 2003 Jun;62(6):627-32 [12834107.001]
  • [Cites] Oncology. 2003;65(1):46-51 [12837982.001]
  • [Cites] Oncogene. 2003 Aug 11;22(33):5181-91 [12910255.001]
  • [Cites] Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):137-40 [14969745.001]
  • [Cites] Cancer Res. 2004 May 1;64(9):3103-11 [15126347.001]
  • [Cites] Lancet. 2004 Sep 25-Oct 1;364(9440):1157-66 [15451223.001]
  • [Cites] Cancer Res. 1977 Mar;37(3):718-20 [189911.001]
  • [Cites] Prog Clin Biol Res. 1983;105:205-21 [6304758.001]
  • (PMID = 15717928.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS043279; United States / NINDS NIH HHS / NS / K08NS43279
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC554768
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59. Massimino M, Gandola L, Collini P, Seregni E, Marchianò A, Serra A, Pignoli E, Spreafico F, Pallotti F, Terenziani M, Biassoni V, Bombardieri E, Fossati-Bellani F: Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor. Int J Radiat Oncol Biol Phys; 2007 Oct 1;69(2):404-10
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  • [Title] Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor.
  • Hence, our study was launched in 1998 to evaluate the protective effect of TSH suppression during CSI for medulloblastoma/primitive neuroectodermal tumor.
  • PATIENTS AND METHODS: From Jan 1998 to Feb 2001, a total of 37 euthyroid children scheduled for CSI for medulloblastoma/primitive neuroectodermal tumor underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of CSI.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Hypothyroidism / prevention & control. Medulloblastoma / radiotherapy. Neuroectodermal Tumors, Primitive / radiotherapy. Thyrotropin / antagonists & inhibitors
  • [MeSH-minor] Adolescent. Adult. Biomarkers / blood. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Infant. Male. Radiotherapy Dosage. Thyroxine / blood. Triiodothyronine / blood


60. Matsumoto J, Kochi M, Morioka M, Nakamura H, Makino K, Hamada J, Kuratsu J, Ushio Y: A long-term ventricular drainage for patients with germ cell tumors or medulloblastoma. Surg Neurol; 2006 Jan;65(1):74-80; discussion 80
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  • [Title] A long-term ventricular drainage for patients with germ cell tumors or medulloblastoma.
  • BACKGROUND: Hydrocephalus associated with intracranial germ cell tumors or disseminated medulloblastoma has been treated with ventriculoperitoneal shunt.
  • However, this procedure has a potential risk of intraperitoneal metastasis of these brain tumors.
  • METHODS: From 1979 to 2003, we have treated 96 patients with germ cell tumors and medulloblastoma in our hospital.
  • Of 96 patients, 59 (germ cell tumor, 31; medulloblastoma, 28) had hydrocephalus and 13 needed long-term cerebrospinal fluid drainage to manage the obstructive hydrocephalus due to persistent tumor or communicating hydrocephalus due to dissemination.
  • CONCLUSIONS: Percutaneous long-tunneled ventricular drainage was an effective method to manage long-lasting obstructive or communicating hydrocephalus with germ cell tumors and medulloblastoma.
  • [MeSH-major] Brain Neoplasms / complications. Hydrocephalus / etiology. Hydrocephalus / surgery. Medulloblastoma / complications. Neoplasms, Germ Cell and Embryonal / complications. Ventriculoperitoneal Shunt
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Incidence. Infant. Infection / epidemiology. Male. Postoperative Complications / epidemiology. Retrospective Studies. Time Factors


61. Yong RL, Kavanagh EC, Fenton D, Dorovini-Zis K, Heran MK, Haw CS: Midline cerebellar medulloblastoma in a seventy-one-year-old patient. Can J Neurol Sci; 2006 Feb;33(1):101-4
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  • [Title] Midline cerebellar medulloblastoma in a seventy-one-year-old patient.
  • BACKGROUND: Medulloblastoma is the most common malignant central nervous system tumour in children but, in contrast, quite rare in adults.
  • We present the unusual case of a 71-year-old man who presented with a fourth ventricular mass that proved to be a medulloblastoma.
  • A CT scan of the brain revealed a hyperattenuating, partially calcified, avidly enhancing mass within the fourth ventricle.
  • These findings were consistent with a classical medulloblastoma.
  • CONCLUSION: Adult medulloblastoma should be considered in the differential diagnosis of a partially calcified hyperattenuating mass within the fourth ventricle.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebral Ventricle Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Aged. Brain Neoplasms / pathology. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Fourth Ventricle / pathology. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Phosphopyruvate Hydratase / metabolism. Synaptophysin / metabolism. Tomography, X-Ray Computed

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  • (PMID = 16583731.001).
  • [ISSN] 0317-1671
  • [Journal-full-title] The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • [ISO-abbreviation] Can J Neurol Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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62. Maddrey AM, Bergeron JA, Lombardo ER, McDonald NK, Mulne AF, Barenberg PD, Bowers DC: Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. J Neurooncol; 2005 May;72(3):245-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma.
  • PURPOSE: Survivors of medulloblastoma, the most frequently occurring malignant brain tumor of childhood, suffer neuropsychological damage in the first decade after diagnosis.
  • Cognitive performance, psychosocial functioning and quality of life were assessed in medulloblastoma survivors in the second decade after diagnosis.
  • RESULTS: Sixteen medulloblastoma survivors [mean age at diagnosis: 7.2 years, range: 1-15 years; 6 males] were tested at a mean age of 22.2 years [range: 13.6-27.9 years].
  • CONCLUSION: Survivors of childhood medulloblastoma frequently suffer severe persistent deficits in a wide-range of neuropsychological functional domains.
  • These severe neuropsychological and psychosocial deficiencies justify further attempts to reduce or delay the use of craniospinal radiation therapy for childhood medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / psychology. Medulloblastoma / psychology. Quality of Life. Survivors / psychology
  • [MeSH-minor] Activities of Daily Living. Adult. Child. Cognition / physiology. Cognition Disorders / etiology. Cognition Disorders / psychology. Education. Employment. Female. Humans. Intelligence Tests. Interpersonal Relations. Male. Neuropsychological Tests. Psychomotor Performance / physiology. Surveys and Questionnaires

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  • [Cites] Eur J Cancer. 2002 Sep;38(14):1824-31 [12204663.001]
  • [Cites] Arch Clin Neuropsychol. 1990;5(1):1-14 [14589539.001]
  • [Cites] Cancer Pract. 1995 Jan-Feb;3(1):47-53 [7704061.001]
  • [Cites] J Neurooncol. 1996 Jul;29(1):91-101 [8817420.001]
  • [Cites] Eur J Cancer. 1998 Nov;34(12):1902-9 [10023313.001]
  • [Cites] Am J Roentgenol Radium Ther Nucl Med. 1954 Apr;71(4):659-68 [13148416.001]
  • [Cites] J Clin Oncol. 2001 Apr 15;19(8):2302-8 [11304784.001]
  • [Cites] Oncol Nurs Forum. 1990 May-Jun;17(3 Suppl):15-9; discussion 20-1 [2342979.001]
  • [Cites] Dev Med Child Neurol. 2000 Nov;42(11):741-5 [11104345.001]
  • [Cites] Brain Cogn. 1990 Jul;13(2):233-81 [2390236.001]
  • [Cites] J Clin Oncol. 2001 Aug 1;19(15):3470-6 [11481352.001]
  • [Cites] J Clin Psychol. 1993 May;49(3):372-82 [8315040.001]
  • [Cites] Clin Endocrinol (Oxf). 1976 May;5(3):287-90 [954222.001]
  • [Cites] Dev Med Child Neurol. 1999 Oct;41(10):683-8 [10587045.001]
  • [Cites] J Clin Oncol. 2003 Jul 15;21(14):2754-9 [12860955.001]
  • [Cites] J Neuropsychiatry Clin Neurosci. 1998 Fall;10(4):426-32 [9813788.001]
  • [Cites] Cancer. 1984 Sep 1;54(5):825-9 [6744214.001]
  • [Cites] J Clin Oncol. 1993 Jun;11(6):1033-8 [8501489.001]
  • [Cites] J Clin Oncol. 1991 Apr;9(4):592-9 [2066756.001]
  • [Cites] Arch Dis Child. 1987 May;62(5):461-4 [3606177.001]
  • [Cites] J Clin Oncol. 1999 Dec;17(12):3720-8 [10577843.001]
  • [Cites] Childs Nerv Syst. 1995 Jun;11(6):340-5; discussion 345-6 [7671269.001]
  • [Cites] Ann Neurol. 1999 Dec;46(6):834-41 [10589535.001]
  • [Cites] Qual Life Res. 1998 Apr;7(3):257-66 [9584556.001]
  • [Cites] Brain. 2000 May;123 ( Pt 5):1041-50 [10775548.001]
  • [Cites] Neuropediatrics. 1991 Feb;22(1):36-42 [2038426.001]
  • [Cites] Br J Cancer. 1990 Apr;61(4):622-5 [2109998.001]
  • [Cites] J Clin Epidemiol. 1992 Jul;45(7):743-60 [1619454.001]
  • [Cites] Br J Cancer. 1988 Jan;57(1):109-12 [3348942.001]
  • [Cites] J Am Geriatr Soc. 1992 Dec;40(12):1221-6 [1447438.001]
  • [Cites] Eur Urol. 2000 May;37(5):541-51 [10765092.001]
  • [Cites] J Clin Oncol. 1998 May;16(5):1723-8 [9586884.001]
  • [Cites] J Clin Oncol. 1999 Jul;17(7):2127-36 [10561268.001]
  • [Cites] J Psychosom Res. 2000 Jul;49(1):27-34 [11053601.001]
  • [Cites] Br J Neurosurg. 1999 Oct;13(5):480-5 [10627779.001]
  • [Cites] J Clin Oncol. 2000 Apr;18(7):1481-91 [10735896.001]
  • [Cites] J Neurosurg. 2000 Dec;93(6):917-26 [11117863.001]
  • [Cites] J Neurosurg. 1994 Nov;81(5):690-8 [7931615.001]
  • [Cites] Br J Surg. 1966 Sep;53(9):774-7 [5911763.001]
  • [Cites] J Neurooncol. 2001 Nov;55(2):121-31 [11817703.001]
  • [Cites] J Clin Oncol. 2004 Mar 15;22(6):999-1006 [15020603.001]
  • [Cites] J Clin Oncol. 2004 Feb 15;22(4):706-13 [14966095.001]
  • [Cites] Arch Phys Med Rehabil. 1990 Dec;71(13):1058-64 [2256806.001]
  • [Cites] J Neurosurg. 1994 Jun;80(6):1004-10 [8189255.001]
  • [Cites] Med Pediatr Oncol. 1992;20(3):181-91 [1574027.001]
  • [Cites] Med Pediatr Oncol. 1990;18(4):304-10 [2355890.001]
  • [Cites] ANS Adv Nurs Sci. 1985 Oct;8(1):15-24 [3933411.001]
  • (PMID = 15937648.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Jouanneau E, Guzman Tovar RA, Desuzinges C, Frappaz D, Louis-Tisserand G, Sunyach MP, Jouvet A, Sindou M: Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report. Neurosurgery; 2006 Apr;58(4):E789; discussion E789
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  • [Title] Very late frontal relapse of medulloblastoma mimicking a meningioma in an adult: usefulness of 1H magnetic resonance spectroscopy and diffusion-perfusion magnetic resonance imaging for preoperative diagnosis: case report.
  • OBJECTIVE AND IMPORTANCE: We present a rare case of very long-term medulloblastoma relapse in an adult patient and discuss the pattern of recurrence and metabolic imaging of the tumor.
  • CLINICAL PRESENTATION: A 45-year-old man was referred for evaluation of a frontobasal midline tumor 21 years after treatment of a cerebellar medulloblastoma by surgery followed by chemotherapy and craniospinal radiotherapy.
  • Several hypotheses were discussed, such as other radio-induced tumors, sarcomas, high-grade gliomas, or lymphomas (previous chemotherapy) and even recurrence of medulloblastoma.
  • Metabolic imaging favored the diagnosis of medulloblastoma over the initially suspected diagnosis of meningioma.
  • The patient underwent complete removal of the tumor that was confirmed to be a metastasis of his primary medulloblastoma.
  • Our observation validates the clinical interest of preoperative metabolic imaging for brain tumors with distinctive pattern.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Medulloblastoma / diagnosis. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis

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  • (PMID = 16575298.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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64. Brandes AA, Franceschi E, Tosoni A, Blatt V, Ermani M: Long-term results of a prospective study on the treatment of medulloblastoma in adults. Cancer; 2007 Nov 1;110(9):2035-41
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  • [Title] Long-term results of a prospective study on the treatment of medulloblastoma in adults.
  • BACKGROUND: Because medulloblastoma (MB) is rare in adults, the few studies on this condition have been retrospective, and the follow-up has tended to be short.
  • Patients were staged completely with a neuroradiologic examination of the brain and neuroaxis and by cerebrospinal fluid cytology, according to Chang's staging system.
  • CONCLUSIONS: In adult patients with MB, long-term follow-up was essential for evaluating the real impact of treatments.
  • [MeSH-major] Cerebellar Neoplasms / drug therapy. Cerebellar Neoplasms / radiotherapy. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prospective Studies. Radiotherapy. Survival Rate. Time. Treatment Outcome

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  • (PMID = 17823910.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
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65. Rieken S, Gaiser T, Mohr A, Welzel T, Witt O, Kulozik AE, Wick W, Debus J, Combs SE: Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept. BMC Cancer; 2010;10:450
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  • [Title] Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept.
  • BACKGROUND: Desmoplasia in medulloblastoma is often diagnosed in adult patients and was repeatedly associated with improved results.
  • Today, all medulloblastoma patients receive intensive multimodal treatment including surgery, radiotherapy and chemotherapy.
  • METHODS: Twenty patients treated for desmoplastic medulloblastoma in the Department of Radiation Oncology at the University of Heidelberg between 1984 and 2007 were included.
  • Two patients underwent whole brain radiotherapy (WBRT), and 18 patients received craniospinal irradiation (CSI).
  • The median dose to the whole brain and the craniospinal axis was 35.2 Gray (Gy), and 54.4 Gy to the posterior fossa.
  • Five patients died from recurrent medulloblastoma.
  • CONCLUSIONS: Multimodal approaches with surgical resection followed by chemoirradiation achieved high response rates with long OS in desmoplastic medulloblastoma patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebellar Neoplasms / therapy. Cranial Irradiation. Medulloblastoma / therapy. Neoplasm Recurrence, Local / therapy. Neurosurgical Procedures
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • [Cites] J Clin Oncol. 1999 Jul;17(7):2127-36 [10561268.001]
  • [Cites] Pediatr Blood Cancer. 2010 Apr;54(4):635-7 [20146217.001]
  • [Cites] Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2 [10981749.001]
  • [Cites] Neuro Oncol. 2001 Jan;3(1):29-34 [11305414.001]
  • [Cites] J Neurooncol. 2002 Aug;59(1):49-61 [12222838.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2002 Nov 1;54(3):855-60 [12377339.001]
  • [Cites] Neurol India. 2003 Mar;51(1):27-34 [12865511.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):755-61 [14529781.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1161-4 [15001259.001]
  • [Cites] Radiology. 1969 Dec;93(6):1351-9 [4983156.001]
  • [Cites] Cancer. 1971 Oct;28(4):977-83 [5111749.001]
  • [Cites] J Neurosurg. 1990 Apr;72(4):572-82 [2319316.001]
  • [Cites] Eur J Cancer. 1990 Apr;26(4):464-9 [2141512.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1990 Aug;19(2):265-74 [2394606.001]
  • [Cites] Am J Clin Oncol. 1992 Jun;15(3):207-11 [1590272.001]
  • [Cites] J Clin Oncol. 1993 Apr;11(4):616-22 [8478656.001]
  • [Cites] Cancer. 1994 Oct 15;74(8):2352-60 [7922986.001]
  • [Cites] Acta Neurochir (Wien). 1994;127(1-2):65-8 [7942185.001]
  • [Cites] Am J Pathol. 1995 Feb;146(2):472-80 [7856756.001]
  • [Cites] Acta Neurochir (Wien). 1995;132(1-3):59-65 [7754860.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1145-52 [7607936.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1255-7 [7607951.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):951-7 [7607969.001]
  • [Cites] Pediatr Neurosurg. 1996;24(4):167-176; discussion 176-7 [8873158.001]
  • [Cites] J Neurooncol. 1997 Nov;35(2):169-76 [9266455.001]
  • [Cites] J Clin Oncol. 1999 Mar;17(3):832-45 [10071274.001]
  • [Cites] Cancer. 1999 Jul 1;86(1):142-8 [10391574.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):978-86 [15758008.001]
  • [Cites] J Neurol. 2005 Mar;252(3):291-9 [16189725.001]
  • [Cites] J Pediatr Hematol Oncol. 2006 Jun;28(6):374-8 [16794506.001]
  • [Cites] J Clin Oncol. 2006 Sep 1;24(25):4202-8 [16943538.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):433-40 [17498567.001]
  • [Cites] Acta Neuropathol. 2007 Aug;114(2):97-109 [17618441.001]
  • [Cites] Med Oncol. 2008;25(1):69-72 [18188718.001]
  • [Cites] Strahlenther Onkol. 2008 Jan;184(1):8-14 [18188517.001]
  • [Cites] J Clin Oncol. 2009 Apr 1;27(10):1627-36 [19255330.001]
  • [Cites] Cancer. 2000 Jun 15;88(12):2887 [10870076.001]
  • (PMID = 20731859.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2939548
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66. De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY: Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. BMC Cancer; 2006 Sep 12;6:223
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  • [Title] Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.
  • BACKGROUND: Medulloblastoma is the most common malignant brain tumor of childhood.
  • In the present study, we applied cytogenetic characterization to guide the identification of biologically significant genes from gene expression microarray profiles of medulloblastoma.
  • By applying CGH results to gene expression analysis of medulloblastoma, we identified three 8q-mapped genes that are associated with overall survival in the larger group of 64 patients (p < 0.05): eukaryotic translation elongation factor 1D (EEF1D), ribosomal protein L30 (RPL30), and ribosomal protein S20 (RPS20).
  • CONCLUSION: The complementary use of CGH and expression profiles can facilitate the identification of clinically significant candidate genes involved in medulloblastoma growth.
  • We demonstrate that gain of 8q and expression levels of three 8q-mapped candidate genes (EEF1D, RPL30, RPS20) are associated with adverse outcome in medulloblastoma.

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  • [Cites] J Clin Oncol. 2000 Aug;18(16):3004-11 [10944134.001]
  • [Cites] Cancer Res. 1999 Feb 1;59(3):711-9 [9973222.001]
  • [Cites] Mol Pathol. 2000 Dec;53(6):313-9 [11193050.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6 [11134512.001]
  • [Cites] Clin Neurol Neurosurg. 2000 Dec;102(4):203-209 [11154805.001]
  • [Cites] J Clin Oncol. 2001 May 15;19(10):2696-704 [11352962.001]
  • [Cites] Br J Cancer. 2001 Sep 1;85(5):705-12 [11531256.001]
  • [Cites] Neuro Oncol. 1999 Apr;1(2):139-51 [11550309.001]
  • [Cites] Nature. 2002 Jan 24;415(6870):436-42 [11807556.001]
  • [Cites] Cancer. 2002 Jan 15;94(2):552-60 [11900240.001]
  • [Cites] Neuropathol Appl Neurobiol. 2002 Aug;28(4):257-82 [12175339.001]
  • [Cites] Teratog Carcinog Mutagen. 2002;22(5):377-83 [12210501.001]
  • [Cites] J Clin Oncol. 2005 Jan 20;23(3):525-31 [15659498.001]
  • [Cites] BMC Genomics. 2005;6:59 [15854232.001]
  • [Cites] Methods Mol Med. 2005;113:71-83 [15968096.001]
  • [Cites] Clin Cancer Res. 2005 Jul 1;11(13):4733-40 [16000568.001]
  • [Cites] J Clin Oncol. 2005 Dec 1;23(34):8853-62 [16314645.001]
  • [Cites] J Neurooncol. 2005 Dec;75(3):273-8 [16195803.001]
  • [Cites] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886.001]
  • [Cites] Nat Rev Cancer. 2003 Mar;3(3):179-92 [12612653.001]
  • [Cites] Pediatr Neurosurg. 2003 Jul;39(2):60-7 [12845195.001]
  • [Cites] J Neurosurg. 2004 Feb;100(2 Suppl Pediatrics):187-93 [14758948.001]
  • [Cites] J Clin Oncol. 2004 Mar 15;22(6):994-8 [14970184.001]
  • [Cites] J Neurooncol. 2004 Mar-Apr;67(1-2):41-6 [15072446.001]
  • [Cites] J Neuropathol Exp Neurol. 2004 May;63(5):441-9 [15198123.001]
  • [Cites] Mol Carcinog. 2004 Jul;40(3):171-9 [15224349.001]
  • [Cites] Br J Cancer. 2004 Jul 19;91(2):282-6 [15199388.001]
  • [Cites] Clin Cancer Res. 2004 Aug 15;10(16):5482-93 [15328187.001]
  • [Cites] N Engl J Med. 1993 Jun 17;328(24):1725-31 [8388548.001]
  • [Cites] J Neurooncol. 1995;24(1):39-45 [8523074.001]
  • [Cites] J Neurooncol. 1996 Jul;29(1):103-12 [8817421.001]
  • [Cites] Clin Cancer Res. 1996 Sep;2(9):1559-64 [9816333.001]
  • [Cites] Clin Cancer Res. 1997 Mar;3(3):473-8 [9815707.001]
  • [Cites] J Neurosurg. 2000 Sep;93(3):437-48 [10969942.001]
  • (PMID = 16968546.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA105607; United States / NICHD NIH HHS / HD / HD042977; United States / NINDS NIH HHS / NS / NS043517; United States / NICHD NIH HHS / HD / T32 HD042977; United States / NCI NIH HHS / CA / R01 CA105607; United States / NINDS NIH HHS / NS / K08 NS043517; United States / NICHD NIH HHS / HD / K12 HD041648; United States / NCI NIH HHS / CA / R01 CA109467; United States / NICHD NIH HHS / HD / HD041648; United States / NCI NIH HHS / CA / CA109467
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Peptide Elongation Factor 1; 0 / Ribosomal Proteins; 0 / ribosomal protein L30; 0 / ribosomal protein S20
  • [Other-IDs] NLM/ PMC1578584
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67. Bobola MS, Finn LS, Ellenbogen RG, Geyer JR, Berger MS, Braga JM, Meade EH, Gross ME, Silber JR: Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors. Clin Cancer Res; 2005 Oct 15;11(20):7405-14
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  • [Title] Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors.
  • Suppressing Ap endo activity in a human medulloblastoma cell line significantly increased sensitivity to 1,3-bis(2-chlororethyl)-1-nitrosourea and temozolomide, suggesting that the association of tumor activity with TTP reflected, at least in part, abasic site repair.
  • [MeSH-major] Brain Neoplasms / enzymology. DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism. Medulloblastoma / enzymology. Neuroectodermal Tumors, Primitive / enzymology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents, Alkylating / pharmacology. Blotting, Western. Brain / drug effects. Brain / enzymology. Brain / radiation effects. Carmustine / pharmacology. Cell Line, Tumor. Cell Nucleus / enzymology. Cell Survival / drug effects. Cell Survival / genetics. Child. Child, Preschool. Combined Modality Therapy. Disease Progression. Dose-Response Relationship, Drug. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Multivariate Analysis. Oligonucleotides, Antisense / genetics. RNA, Small Interfering / genetics. Time Factors. Transfection

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  • (PMID = 16243814.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA104593; United States / NCI NIH HHS / CA / CA70790; United States / NCI NIH HHS / CA / CA82622
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Oligonucleotides, Antisense; 0 / RNA, Small Interfering; EC 4.2.99.18 / DNA-(Apurinic or Apyrimidinic Site) Lyase; U68WG3173Y / Carmustine
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68. Baryawno N, Sveinbjörnsson B, Eksborg S, Orrego A, Segerström L, Oqvist CO, Holm S, Gustavsson B, Kågedal B, Kogner P, Johnsen JI: Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol; 2008 Oct;10(5):661-74
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  • [Title] Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets.
  • In this study, we show for the first time that medulloblastoma (MB), the most common malignant childhood brain tumor, expresses high levels of COX-2, microsomal prostaglandin E synthase-1, and EP(1) through EP(4) and secretes PGE(2).
  • [MeSH-major] Cerebellar Neoplasms / metabolism. Cyclooxygenase 2 / metabolism. Dinoprostone / metabolism. Medulloblastoma / metabolism. Signal Transduction / physiology
  • [MeSH-minor] Adolescent. Adult. Animals. Apoptosis / drug effects. Apoptosis / physiology. Blotting, Western. Cell Proliferation / drug effects. Child. Child, Preschool. Enzyme Inhibitors / pharmacology. Female. Flow Cytometry. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Mice. Mice, Nude. Middle Aged. Xenograft Model Antitumor Assays

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  • [Cites] Nat Rev Cancer. 2006 Feb;6(2):130-40 [16491072.001]
  • [Cites] Cancer Lett. 1998 Oct 23;132(1-2):17-21 [10397448.001]
  • [Cites] Int J Cancer. 2006 Nov 15;119(10):2247-54 [16921484.001]
  • [Cites] Cancer Res. 2006 Oct 15;66(20):9794-7 [17047037.001]
  • [Cites] Cancer Res. 2006 Dec 1;66(23):11115-9 [17145853.001]
  • [Cites] Clin Cancer Res. 2007 Feb 1;13(3):1036-44 [17289900.001]
  • [Cites] N Engl J Med. 2007 May 24;356(21):2195-8 [17522404.001]
  • [Cites] Acta Neuropathol. 2007 Aug;114(2):97-109 [17618441.001]
  • [Cites] Nat Med. 1999 Dec;5(12):1418-23 [10581086.001]
  • [Cites] J Biol Chem. 2000 Apr 14;275(15):11397-403 [10753955.001]
  • [Cites] Cancer Res. 2000 Sep 1;60(17):4926-31 [10987308.001]
  • [Cites] J Biol Chem. 2000 Oct 20;275(42):32783-92 [10869354.001]
  • [Cites] Cancer Res. 2000 Nov 1;60(21):6045-51 [11085526.001]
  • [Cites] Cancer Res. 2001 Jun 1;61(11):4375-81 [11389063.001]
  • [Cites] Neurosci Lett. 2001 Aug 31;309(3):193-6 [11514074.001]
  • [Cites] FASEB J. 2001 Dec;15(14):2742-4 [11606477.001]
  • [Cites] J Natl Cancer Inst. 2002 Feb 20;94(4):252-66 [11854387.001]
  • [Cites] J Neurooncol. 2002 Apr;57(2):147-50 [12125976.001]
  • [Cites] Biochem J. 2002 Sep 15;366(Pt 3):831-7 [12076251.001]
  • [Cites] Clin Pharmacol Ther. 2002 Nov;72(5):490-7 [12426512.001]
  • [Cites] Int J Cancer. 2003 Apr 20;104(4):418-24 [12584737.001]
  • [Cites] Am J Clin Oncol. 2003 Aug;26(4):S98-102 [12902865.001]
  • [Cites] Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):106-14 [12941466.001]
  • [Cites] Int J Cancer. 2003 Nov 20;107(4):551-6 [14520691.001]
  • [Cites] Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):712-9 [15701860.001]
  • [Cites] Int J Cancer. 2005 Jun 20;115(3):484-92 [15688368.001]
  • [Cites] Cancer Res. 2005 Jun 15;65(12):5038-44 [15958546.001]
  • [Cites] Cancer Lett. 2005 Oct 18;228(1-2):195-201 [15975708.001]
  • [Cites] Cancer Res. 2005 Oct 15;65(20):9501-9 [16230415.001]
  • [Cites] Gut. 2006 Jan;55(1):115-22 [16118353.001]
  • [Cites] J Pathol. 2006 Feb;208(3):356-63 [16353170.001]
  • [Cites] J Cell Physiol. 2006 Apr;207(1):261-70 [16331686.001]
  • [Cites] J Natl Cancer Inst. 2003 Oct 1;95(19):1440-52 [14519750.001]
  • [Cites] Trends Pharmacol Sci. 2003 Oct;24(10):524-9 [14559404.001]
  • [Cites] J Clin Pathol. 2004 Jan;57(1):6-13 [14693827.001]
  • [Cites] Cancer Res. 2004 Feb 15;64(4):1444-51 [14973075.001]
  • [Cites] Biochem Pharmacol. 2004 Mar 15;67(6):1123-30 [15006548.001]
  • [Cites] Lancet Oncol. 2004 Jul;5(7):399-408 [15231246.001]
  • [Cites] J Biol Chem. 2004 Jul 9;279(28):29797-804 [15123663.001]
  • [Cites] Oncol Rep. 2004 Aug;12(2):403-9 [15254709.001]
  • [Cites] Neoplasia. 2004 Jul-Aug;6(4):310-22 [15256053.001]
  • [Cites] Pharmacol Ther. 2004 Aug;103(2):147-66 [15369681.001]
  • [Cites] Cancer Res. 2004 Oct 15;64(20):7210-5 [15492235.001]
  • [Cites] Semin Oncol. 2004 Oct;31(5):666-75 [15497120.001]
  • [Cites] J Pharmacokinet Biopharm. 1974 Apr;2(2):123-48 [4427218.001]
  • [Cites] J Neuropathol Exp Neurol. 1985 Sep;44(5):472-85 [2993532.001]
  • [Cites] Brain Res. 1991 Mar 8;543(1):15-24 [1905180.001]
  • [Cites] Neuron. 1993 Aug;11(2):371-86 [8352945.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2317-21 [8637870.001]
  • [Cites] Cancer Res. 1997 May 1;57(9):1625-9 [9134996.001]
  • [Cites] Cancer Biochem Biophys. 1998 Nov;16(4):301-12 [9925279.001]
  • [Cites] J Natl Cancer Inst. 2006 Jun 7;98(11):736-47 [16757698.001]
  • (PMID = 18715952.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
  • [Other-IDs] NLM/ PMC2666243
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69. Hartmann W, Digon-Söntgerath B, Koch A, Waha A, Endl E, Dani I, Denkhaus D, Goodyer CG, Sörensen N, Wiestler OD, Pietsch T: Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res; 2006 May 15;12(10):3019-27
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  • [Title] Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN.
  • PURPOSE: Medulloblastomas represent the most frequent malignant brain tumors of childhood.
  • Recently, it has been shown that Sonic Hedgehog-induced formation of medulloblastoma in an animal model is significantly enhanced by activation of the phosphatidylinositol 3'-kinase (PI3K) signaling pathway.
  • EXPERIMENTAL DESIGN: To examine a role for PI3K/AKT signaling in the molecular pathogenesis of human medulloblastoma, we did an immunohistochemical study of the expression of Ser473-phosphorylated (p)-AKT protein in 22 medulloblastoma samples: All samples displayed p-AKT expression.
  • To investigate if an activated PI3K/AKT pathway is required for medulloblastoma cell growth, we treated five human medulloblastoma cell lines with increasing concentrations of the PI3K inhibitor LY294002 and analyzed cellular proliferation and apoptosis.
  • As the activation of PI3K/AKT signaling may be associated with alterations of the PTEN gene located at 10q23.3, a chromosomal region subject to frequent allelic losses in medulloblastoma, we screened PTEN for mutations and mRNA expression.
  • RESULTS: Proliferation of all of the medulloblastoma cell lines was dependent on PI3K/AKT signaling, whereas apoptosis was not prominently affected.
  • One medulloblastoma cell line was found to carry a truncating mutation in the PTEN coding sequence.
  • CONCLUSIONS: We conclude that activation of the PI3K/AKT pathway constitutes an important step in the molecular pathogenesis of medulloblastoma and that dysregulation of PTEN may play a significant role in this context.
  • [MeSH-major] Cell Proliferation. Cerebellar Neoplasms / metabolism. Medulloblastoma / metabolism. PTEN Phosphohydrolase / genetics. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism
  • [MeSH-minor] Adult. Child. DNA Mutational Analysis. Humans. Immunohistochemistry. Loss of Heterozygosity. Polymerase Chain Reaction. Polymorphism, Genetic. Signal Transduction. Tumor Cells, Cultured

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  • (PMID = 16707597.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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70. Benesch M, Spiegl K, Winter A, Passini A, Lackner H, Moser A, Sovinz P, Schwinger W, Urban C: A scoring system to quantify late effects in children after treatment for medulloblastoma/ependymoma and its correlation with quality of life and neurocognitive functioning. Childs Nerv Syst; 2009 Feb;25(2):173-81
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  • [Title] A scoring system to quantify late effects in children after treatment for medulloblastoma/ependymoma and its correlation with quality of life and neurocognitive functioning.
  • BACKGROUND: The aim of this study was to quantify the severity of late effects by a simple numerical score (late effects severity score, LESS) in patients who received radiochemotherapy for medulloblastoma or ependymoma.
  • Twenty-three patients with medulloblastoma (n = 18) or ependymoma (n = 5) underwent extensive neurocognitive and QoL testing at a median of 56 months (range, 1-174) after the end of treatment.
  • RESULTS: Patients with medulloblastoma/ependymoma had significantly higher LESS and significantly lower Wechsler Adult Intelligence Scale (WAIS)/Wechsler Intelligence Scales for Children (WISC) scores compared to patients with LGG.
  • Comparison of QoL and late effects in patients with medulloblastoma/ependymoma demonstrated a significant negative correlation only for neurological late effects and the KINDL score suggesting that younger patients with more severe late effects reported on a worse QoL.
  • CONCLUSIONS: This LESS seems to be a simple and practical tool to quantify late effects in former brain tumor patients.
  • [MeSH-major] Ependymoma / therapy. Medulloblastoma / therapy. Nervous System Diseases / physiopathology. Quality of Life
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cognition / drug effects. Cognition / physiology. Cognition / radiation effects. Combined Modality Therapy / adverse effects. Drug-Related Side Effects and Adverse Reactions. Endocrine System / drug effects. Endocrine System / physiopathology. Endocrine System / radiation effects. Female. Follow-Up Studies. Hearing / drug effects. Hearing / physiology. Hearing / radiation effects. Humans. Infant. Magnetic Resonance Imaging / methods. Male. Outcome Assessment (Health Care) / methods. Radiotherapy / adverse effects. Time Factors. Verbal Learning / drug effects. Verbal Learning / physiology. Verbal Learning / radiation effects. Vision, Ocular / drug effects. Vision, Ocular / physiology. Vision, Ocular / radiation effects. Young Adult

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  • [Cites] J Clin Oncol. 1999 Mar;17(3):832-45 [10071274.001]
  • [Cites] Neuropediatrics. 2005 Dec;36(6):357-65 [16429375.001]
  • [Cites] J Clin Oncol. 2003 Sep 1;21(17):3255-61 [12947060.001]
  • [Cites] Qual Life Res. 1998 Jul;7(5):399-407 [9691720.001]
  • [Cites] Schweiz Arch Neurol Psychiatr (1985). 1990;141(1):21-30 [1690447.001]
  • [Cites] J Clin Oncol. 1999 Nov;17(11):3476-86 [10550145.001]
  • [Cites] Eur J Cancer. 2006 Sep;42(13):2064-80 [16919771.001]
  • [Cites] Cancer. 1984 Jul 1;54(1):135-8 [6722738.001]
  • [Cites] J Natl Cancer Inst. 1993 Mar 3;85(5):365-76 [8433390.001]
  • [Cites] Lancet Oncol. 2004 Jul;5(7):399-408 [15231246.001]
  • [Cites] J Clin Oncol. 1991 Apr;9(4):592-9 [2066756.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):287-95 [10661334.001]
  • [Cites] J Clin Oncol. 2006 Jun 1;24(16):2527-35 [16735705.001]
  • [Cites] Cancer. 1982 Apr 15;49(8):1580-6 [7066864.001]
  • [Cites] J Clin Oncol. 1999 Dec;17(12):3720-8 [10577843.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1999 Aug 1;45(1):137-45 [10477017.001]
  • [Cites] J Pediatr. 1978 Dec;93(6):903-9 [214533.001]
  • [Cites] Childs Nerv Syst. 1990 Mar;6(2):60-5 [2340529.001]
  • [Cites] J Clin Oncol. 1998 May;16(5):1723-8 [9586884.001]
  • [Cites] Eur J Pediatr. 2000 Oct;159(10):750-8 [11039130.001]
  • [Cites] J Neurosurg. 1998 Apr;88(4):695-703 [9525716.001]
  • [Cites] J Neurooncol. 2005 May;72(3):245-53 [15937648.001]
  • [Cites] Blood. 1997 Mar 15;89(6):2079-88 [9058730.001]
  • [Cites] J Clin Oncol. 2005 Aug 20;23(24):5493-500 [16110009.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):269-79 [10661332.001]
  • [Cites] Lancet Oncol. 2006 Oct;7(10):813-20 [17012043.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1994 Jan 15;28(2):381-6 [8276653.001]
  • [Cites] Int J Cancer Suppl. 1999;12:83-6 [10679876.001]
  • [Cites] J Pediatr. 2002 Nov;141(5):683-8 [12410198.001]
  • [Cites] Pediatr Neurol. 2003 Jan;28(1):42-7 [12657419.001]
  • [Cites] J Neurosurg. 1994 Jun;80(6):1004-10 [8189255.001]
  • [Cites] Arch Surg. 2007 Nov;142(11):1043-8 [18025331.001]
  • [Cites] Cancer. 1997 Jul 15;80(2):341-7 [9217048.001]
  • [Cites] J Neurooncol. 2006 Jun;78(2):199-205 [16739030.001]
  • (PMID = 18974990.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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71. Bunin GR, Kushi LH, Gallagher PR, Rorke-Adams LB, McBride ML, Cnaan A: Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States). Cancer Causes Control; 2005 Sep;16(7):877-91
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  • [Title] Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States).
  • Fruit, vegetables, vitamin C, and folate during pregnancy have been suggested as protective factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children.
  • As hypothesized, cured meats were not associated with medulloblastoma/PNET, in contrast to other childhood brain tumors.
  • French fries (OR = 2.4, 95% CI: 1.2, 4.9) and chili peppers (OR = 1.8, 95% CI: 1.0, 3.0) were associated with medulloblastoma/PNET.
  • [MeSH-major] Cerebellar Neoplasms / epidemiology. Food Habits. Medulloblastoma / epidemiology
  • [MeSH-minor] Adult. Antioxidants / administration & dosage. Ascorbic Acid / administration & dosage. Candy / adverse effects. Female. Folic Acid / administration & dosage. Fruit. Humans. Maternal Welfare. Meat / adverse effects. Micronutrients. Odds Ratio. Pregnancy. United States / epidemiology. Vegetables. Vitamin B Complex / administration & dosage

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  • (PMID = 16132798.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA15488; United States / NCI NIH HHS / CA / CA60951
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Micronutrients; 12001-76-2 / Vitamin B Complex; 935E97BOY8 / Folic Acid; PQ6CK8PD0R / Ascorbic Acid
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72. Campbell RM, Mader RD, Dufresne RG Jr: Meningiomas after medulloblastoma irradiation treatment in a patient with basal cell nevus syndrome. J Am Acad Dermatol; 2005 Nov;53(5 Suppl 1):S256-9
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  • [Title] Meningiomas after medulloblastoma irradiation treatment in a patient with basal cell nevus syndrome.
  • A 23-year-old woman with basal cell nevus syndrome (BCNS), or Gorlin's syndrome, was given the diagnosis at age 2 years of a medulloblastoma that was resected and treated postoperatively with craniospinal irradiation.
  • [MeSH-major] Basal Cell Nevus Syndrome / epidemiology. Cerebellar Neoplasms / radiotherapy. Medulloblastoma / radiotherapy. Meningeal Neoplasms / epidemiology. Meningioma / epidemiology
  • [MeSH-minor] Adult. Brain Neoplasms / epidemiology. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Parietal Lobe. Radiotherapy Dosage. Time Factors

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  • (PMID = 16227103.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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73. Daniel RA, Rozanska AL, Mulligan EA, Drew Y, Thomas HD, Castelbuono DJ, Hostomsky Z, Plummer ER, Tweddle DA, Boddy AV, Clifford SC, Curtin NJ: Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. Br J Cancer; 2010 Nov 9;103(10):1588-96
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  • [Title] Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.
  • BACKGROUND: Temozolomide shows activity against medulloblastoma, the most common malignant paediatric brain tumour.
  • Poly(ADP-ribose) polymerase (PARP) inhibitors enhance temozolomide activity in extracranial adult and paediatric human malignancies.
  • METHODS: We assessed the effect of AG-014699, a clinically active PARP inhibitor, on temozolomide-induced growth inhibition in human medulloblastoma models.
  • AG-014699 was not toxic, accumulated and reduced PARP activity ≥75% in xenograft and brain tissues.
  • CONCLUSION: We show for the first time central nervous system penetration and inhibition of brain PARP activity by AG-014699.

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  • [Cites] Clin Cancer Res. 2005 May 1;11(9):3402-9 [15867241.001]
  • [Cites] Nat Rev Drug Discov. 2005 May;4(5):421-40 [15864271.001]
  • [Cites] Genes Chromosomes Cancer. 2006 Jan;45(1):47-60 [16149064.001]
  • [Cites] Neurosurg Focus. 2005 Nov;19(5):E10 [16398460.001]
  • [Cites] Childs Nerv Syst. 2006 Jul;22(7):652-61 [16565851.001]
  • [Cites] Eur J Cancer. 2006 Sep;42(14):2335-42 [16899365.001]
  • [Cites] Clin Cancer Res. 2007 Mar 15;13(6):1663-74 [17363519.001]
  • [Cites] Mol Cancer Ther. 2007 Mar;6(3):945-56 [17363489.001]
  • [Cites] Clin Cancer Res. 2007 May 1;13(9):2728-37 [17473206.001]
  • [Cites] Expert Opin Ther Targets. 2007 Jun;11(6):783-99 [17504016.001]
  • [Cites] Cancer. 2007 Oct 1;110(7):1542-50 [17705175.001]
  • [Cites] Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6712-8 [18006772.001]
  • [Cites] Nat Clin Pract Oncol. 2008 Aug;5(8):476-86 [18542116.001]
  • [Cites] Arch Dis Child Educ Pract Ed. 2008 Oct;93(5):137-44 [18809691.001]
  • [Cites] Clin Cancer Res. 2008 Dec 1;14(23):7917-23 [19047122.001]
  • [Cites] Cancer Res. 2009 Jan 1;69(1):120-7 [19117994.001]
  • [Cites] Clin Cancer Res. 2009 Feb 15;15(4):1241-9 [19174487.001]
  • [Cites] Childs Nerv Syst. 2009 May;25(5):535-41 [19107490.001]
  • [Cites] N Engl J Med. 2009 Jul 9;361(2):123-34 [19553641.001]
  • [Cites] Br J Neurosurg. 2009 Aug;23(4):364-75 [19637007.001]
  • [Cites] Clin Cancer Res. 2009 Oct 1;15(19):6106-12 [19789326.001]
  • [Cites] Semin Oncol. 2001 Aug;28(4 Suppl 13):3-12 [11550133.001]
  • [Cites] Clin Cancer Res. 2000 Mar;6(3):998-1007 [10741727.001]
  • [Cites] Neuro Oncol. 2009 Oct;11(5):458-67 [19179424.001]
  • [Cites] J Clin Oncol. 2003 Jul 1;21(13):2525-8 [12829671.001]
  • [Cites] Clin Cancer Res. 2003 Nov 1;9(14):5370-9 [14614022.001]
  • [Cites] J Natl Cancer Inst. 2004 Jan 7;96(1):56-67 [14709739.001]
  • [Cites] Clin Cancer Res. 2004 Feb 1;10(3):881-9 [14871963.001]
  • [Cites] J Med Chem. 2004 Aug 12;47(17):4151-4 [15293985.001]
  • [Cites] Cancer Res. 1995 Jul 1;55(13):2853-7 [7796412.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):997-1003 [15758010.001]
  • [Cites] Mol Cancer Ther. 2005 Sep;4(9):1364-8 [16170028.001]
  • (PMID = 20978505.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United Kingdom / Cancer Research UK / / C8464/A5414; United Kingdom / Department of Health / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Indoles; 0 / Poly(ADP-ribose) Polymerase Inhibitors; 7GR28W0FJI / Dacarbazine; 8237F3U7EH / rucaparib; 85622-93-1 / temozolomide; EC 2.4.2.30 / PARP1 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ PMC2990587
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74. Nieder C, Mehta MP, Jalali R: Combined radio- and chemotherapy of brain tumours in adult patients. Clin Oncol (R Coll Radiol); 2009 Sep;21(7):515-24
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  • [Title] Combined radio- and chemotherapy of brain tumours in adult patients.
  • In order to examine the current standards of care regarding combined radio- and chemotherapy for adult patients with brain tumours, a review was carried out of recent studies examining surgery, radiotherapy and chemotherapy in high-grade glioma, medulloblastoma and primary central nervous system lymphoma.
  • In medulloblastoma, no comparable landmark trial exists and therefore combined radiochemotherapy must be considered investigational.
  • The challenges associated with brain tumour treatment remain formidable, but rationally designed clinical trials are gradually leading to improved outcomes.
  • [MeSH-major] Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy

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  • (PMID = 19487112.001).
  • [ISSN] 1433-2981
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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75. Weller M: [Chemotherapy for brain tumors in adult patients]. Nervenarzt; 2008 Feb;79(2):231-41
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  • [Title] [Chemotherapy for brain tumors in adult patients].
  • Chemotherapy has become a third major treatment option for patients with brain tumors, in addition to surgery and radiotherapy.
  • Outside such clinical trials chemotherapy is used in addition to radiotherapy, e.g., in anaplastic astrocytoma, medulloblastoma or germ cell tumors, or as an alternative to radiotherapy, e.g., in anaplastic oligodendroglial tumors or low-grade gliomas.
  • Primary cerebral lymphomas are probably the only brain tumors which can be cured by chemotherapy alone and only by chemotherapy.
  • The chemotherapy of brain metastases follows the recommendations for the respective primary tumors.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Glioma / drug therapy. Lymphoma / drug therapy
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 19. Combined Modality Therapy. DNA Methylation. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Dacarbazine / adverse effects. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Genetic Markers / genetics. Humans. Prognosis. Promoter Regions, Genetic / genetics. Topotecan / adverse effects. Topotecan / therapeutic use. Tumor Suppressor Proteins / genetics

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  • [Cites] J Neurooncol. 2005 Feb;71(3):271-6 [15735916.001]
  • [Cites] Neurosurgery. 2002 Jul;51(1):44-55; discussion 55-6 [12182434.001]
  • [Cites] Neurologist. 2006 Jul;12(4):179-87 [16832237.001]
  • [Cites] Curr Treat Options Neurol. 2006 Jul;8(4):346-57 [16942677.001]
  • [Cites] Nervenarzt. 2003 Dec;74(12):1139-49 [14994756.001]
  • [Cites] J Clin Oncol. 2003 Sep 1;21(17):3276-84 [12947063.001]
  • [Cites] J Neurol. 2005 Mar;252(3):291-9 [16189725.001]
  • [Cites] Cancer. 2005 Jul 1;104(1):143-8 [15912507.001]
  • [Cites] J Clin Oncol. 2007 Aug 1;25(22):3357-61 [17664483.001]
  • [Cites] J Clin Oncol. 2006 Jun 20;24(18):2707-14 [16782910.001]
  • [Cites] Acta Neurochir (Wien). 2006 Mar;148(3):269-75; discussion 275 [16482400.001]
  • [Cites] Clin Cancer Res. 2007 Feb 15;13(4):1253-9 [17317837.001]
  • [Cites] J Clin Oncol. 2006 Jun 20;24(18):2715-22 [16782911.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10 ):997-1003 [15758010.001]
  • [Cites] Hematol Oncol Clin North Am. 2006 Dec;20(6):1287-95 [17113463.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10 ):987-96 [15758009.001]
  • (PMID = 18253773.001).
  • [ISSN] 0028-2804
  • [Journal-full-title] Der Nervenarzt
  • [ISO-abbreviation] Nervenarzt
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Genetic Markers; 0 / Tumor Suppressor Proteins; 7GR28W0FJI / Dacarbazine; 7M7YKX2N15 / Topotecan; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes; YF1K15M17Y / temozolomide
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76. Bull KS, Spoudeas HA, Yadegarfar G, Kennedy CR, CCLG: Reduction of health status 7 years after addition of chemotherapy to craniospinal irradiation for medulloblastoma: a follow-up study in PNET 3 trial survivors on behalf of the CCLG (formerly UKCCSG). J Clin Oncol; 2007 Sep 20;25(27):4239-45
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  • [Title] Reduction of health status 7 years after addition of chemotherapy to craniospinal irradiation for medulloblastoma: a follow-up study in PNET 3 trial survivors on behalf of the CCLG (formerly UKCCSG).
  • PURPOSE: To compare quality of survival after craniospinal irradiation (CSI) alone with survival after CSI plus chemotherapy (CT) for medulloblastoma.
  • PATIENTS AND METHODS: Follow-up study of surviving UK patients with medulloblastoma diagnosed between 1992 and 2000 treated according to one or other treatment arm of the PNET 3 controlled trial.
  • CONCLUSION: The addition of CT to CSI for medulloblastoma was associated with a significant decrease in health status.
  • [MeSH-major] Cranial Irradiation / adverse effects. Medulloblastoma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / radiotherapy. Child. Clinical Trials as Topic. Follow-Up Studies. Health Status. Humans. Quality of Life. Spinal Neoplasms / radiotherapy. Survivors. Treatment Outcome

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  • [CommentIn] Curr Neurol Neurosci Rep. 2008 Mar;8(2):111-3 [18460278.001]
  • (PMID = 17878477.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Brandes AA, Franceschi E: Neuro-oncology: Genetic variation in pediatric and adult brain tumors. Nat Rev Neurol; 2010 Dec;6(12):653-4
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  • [Title] Neuro-oncology: Genetic variation in pediatric and adult brain tumors.
  • Age-dependent gene expression might affect tumor biology; therefore, therapies for adult medulloblastomas or gliomas might not produce the same clinical outcomes in pediatric patients, and vice versa.
  • [MeSH-major] Brain Neoplasms / genetics. Cerebellar Neoplasms / genetics. Gene Expression Profiling. Glioma / genetics. Medulloblastoma / genetics
  • [MeSH-minor] Adult. Child. Genetic Variation. Humans

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  • (PMID = 21131914.001).
  • [ISSN] 1759-4766
  • [Journal-full-title] Nature reviews. Neurology
  • [ISO-abbreviation] Nat Rev Neurol
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] England
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78. Fouladi M, Nicholson HS, Zhou T, Laningham F, Helton KJ, Holmes E, Cohen K, Speights RA, Wright J, Pollack IF, Children's Oncology Group: A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study. Cancer; 2007 Dec 1;110(11):2535-41
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  • [Title] A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study.
  • BACKGROUND: An open-label Phase II study of tipifarnib was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB)/primitive neuroectodermal tumor (PNET), high-grade glioma (HGG), and diffuse intrinsic brainstem glioma (BSG).
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy. Medulloblastoma / drug therapy. Quinolones / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Female. Humans. Male. Neuroectodermal Tumors / drug therapy. Treatment Outcome


79. Allen J, Donahue B, Mehta M, Miller DC, Rorke LB, Jakacki R, Robertson P, Sposto R, Holmes E, Vezina G, Muraszko K, Puccetti D, Prados M, Chan KW: A phase II study of preradiotherapy chemotherapy followed by hyperfractionated radiotherapy for newly diagnosed high-risk medulloblastoma/primitive neuroectodermal tumor: a report from the Children's Oncology Group (CCG 9931). Int J Radiat Oncol Biol Phys; 2009 Jul 15;74(4):1006-11
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  • [Title] A phase II study of preradiotherapy chemotherapy followed by hyperfractionated radiotherapy for newly diagnosed high-risk medulloblastoma/primitive neuroectodermal tumor: a report from the Children's Oncology Group (CCG 9931).
  • PURPOSE: To verify feasibility and monitor progression-free survival and overall survival in children with high-risk medulloblastoma and noncerebellar primitive neuroectodermal tumors (PNETs) treated in a Phase II study with preradiotherapy chemotherapy (CHT) followed by high-dose, hyperfractionated craniospinal radiotherapy (CSRT).
  • METHODS AND MATERIALS: Eligibility criteria included age >3 years at diagnosis, medulloblastoma with either high M stage and/or >1.5 cm(2) postoperative residual disease, and all patients with noncerebellar PNET.

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  • [Cites] Int J Radiat Oncol Biol Phys. 1999 Jan 15;43(2):279-85 [10030250.001]
  • [Cites] Klin Padiatr. 1998 Jul-Aug;210(4):227-33 [9743957.001]
  • [Cites] Cancer J. 2004 Nov-Dec;10(6):386-90 [15701271.001]
  • [Cites] Eur J Cancer. 2005 Mar;41(5):727-34 [15763649.001]
  • [Cites] Australas Radiol. 2005 Aug;49(4):298-303 [16026436.001]
  • [Cites] Acta Oncol. 2005;44(6):554-62 [16165914.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):711-6 [15927408.001]
  • [Cites] J Clin Oncol. 2006 Sep 1;24(25):4202-8 [16943538.001]
  • [Cites] Lancet Oncol. 2006 Oct;7(10):813-20 [17012043.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):269-79 [10661332.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1287-94 [11483340.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1982 Feb;8(2):219-26 [7085377.001]
  • [Cites] Cancer. 1983 Dec 1;52(11):2001-6 [6627214.001]
  • [Cites] J Clin Oncol. 1988 Apr;6(4):649-53 [3258630.001]
  • [Cites] J Clin Oncol. 1989 Jun;7(6):754-60 [2715805.001]
  • [Cites] Am J Pediatr Hematol Oncol. 1990 Fall;12(3):297-300 [2173440.001]
  • [Cites] Cancer. 1993 Nov 1;72(9):2755-62 [8402500.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jan 15;31(2):371-8 [7836091.001]
  • [Cites] J Clin Oncol. 1995 Jun;13(6):1377-83 [7751882.001]
  • [Cites] J Clin Oncol. 1995 Sep;13(9):2247-54 [7666082.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1996 Dec 1;36(5):1155-61 [8985038.001]
  • [Cites] Med Pediatr Oncol. 1997 Jun;28(6):387-400 [9143382.001]
  • [Cites] Cancer. 1997 Aug 15;80(4):798-804 [9264364.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1997 Aug 1;39(1):15-24 [9300735.001]
  • [Cites] J Clin Oncol. 1999 Mar;17(3):832-45 [10071274.001]
  • (PMID = 19356859.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA003888-44; United States / NCI NIH HHS / CA / U10 CA003888; United States / NCI NIH HHS / CA / U10 CA098543; United States / NCI NIH HHS / CA / U10 CA003888-44
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ NIHMS128135; NLM/ PMC2739055
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80. Ellert-Miklaszewska A, Grajkowska W, Gabrusiewicz K, Kaminska B, Konarska L: Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors. Brain Res; 2007 Mar 16;1137(1):161-9
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  • [Title] Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors.
  • The efficacy of cannabinoids against high-grade glioma in animal models, mediated by two specific receptors, CB1 and CB2, raised promises for targeted treatment of the most frequent and malignant primary brain tumors.
  • Unlike the abundantly expressed CB1, the CB2 receptor shows a restricted distribution in normal brain.
  • Although brain tumors constitute the second most common malignancy in children and the prevalence of histological types of brain tumors vary significantly between the adult and pediatric populations, cannabinoid receptor expression in pediatric tumors remains unknown.
  • In the present study, we compared the expression of the CB2 receptor in paraffin-embedded sections from primary brain tumors of adult and pediatric patients.
  • In contrast, all examined cases of embryonal tumors (medulloblastoma and S-PNET), the most frequently diagnosed malignant brain tumors in childhood, showed no or trace CB2 immunoreactivity.
  • Our results suggest that the CB2 receptor expression depends primarily on the histopathological origin of the brain tumor cells and differentiation state, reflecting the tumor grade.
  • [MeSH-major] Brain Neoplasms / metabolism. Gene Expression Regulation, Neoplastic / physiology. Receptor, Cannabinoid, CB2 / metabolism
  • [MeSH-minor] Adolescent. Adult. Age Factors. Astrocytoma / metabolism. Child. Glioblastoma / metabolism. Histocompatibility Antigens / metabolism. Humans. Immunohistochemistry. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 17239827.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Histocompatibility Antigens; 0 / Receptor, Cannabinoid, CB2
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81. Kieran MW, Walker D, Frappaz D, Prados M: Brain tumors: from childhood through adolescence into adulthood. J Clin Oncol; 2010 Nov 10;28(32):4783-9
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  • [Title] Brain tumors: from childhood through adolescence into adulthood.
  • Clinical care is currently divided into adult or pediatric care; adolescent patients require specific expertise that most clinical practices do not have.
  • Health systems historically have varied widely in the age they choose for allocating an individual to the adult model of health care.
  • Some brain tumors are unique to children, some occur predominantly in adults, and others peak in adolescence.
  • Delays in the diagnosis of brain tumors can occur at any age but are particularly common in adolescence because of difficulties of accessing health systems, the difficulties of discriminating pathologic from typical adolescent behavioral characteristics, and changing endocrine function.
  • This article will discuss the changing brain tumor profile of children, adolescents, and adults, with a focus on our limited understanding of the adolescent/young adult transition period.
  • [MeSH-major] Brain Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adolescent Medicine. Adult. Brain / growth & development. Child. Continuity of Patient Care. Glioma / diagnosis. Glioma / therapy. Humans. Medulloblastoma / diagnosis. Medulloblastoma / therapy. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / therapy

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  • (PMID = 20458039.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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82. Korshunov A, Remke M, Werft W, Benner A, Ryzhova M, Witt H, Sturm D, Wittmann A, Schöttler A, Felsberg J, Reifenberger G, Rutkowski S, Scheurlen W, Kulozik AE, von Deimling A, Lichter P, Pfister SM: Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification. J Clin Oncol; 2010 Jun 20;28(18):3054-60
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  • [Title] Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.
  • PURPOSE: Medulloblastoma (MB) is the most common malignant brain tumor in children, whereas it rarely presents in adults.
  • We aimed to identify genetic aberrations in 146 adult MBs to evaluate age-dependent differences in tumor biology and adapt age-specific risk stratification models.
  • METHODS: As a screening set, we studied a cohort of 34 adult MBs by using array-based comparative genomic hybridization comparing molecular results with clinical data.
  • DNA copy number aberrations identified as possible prognostic markers were validated in an independent cohort of 112 adult patients with MB by fluorescent in situ hybridization analysis.
  • RESULTS: CDK6 amplification, 10q loss, and 17q gain are the most powerful prognostic markers in adult MB.
  • Whereas MYC/MYCN oncogene amplifications had a high prognostic value in pediatric MB, these aberrations were rarely observed in adult tumors.
  • Surprisingly, adult MBs with 6q deletion and nuclear beta-catenin activation did not share the excellent prognosis with their pediatric counterparts.
  • CONCLUSION: Adult MB is distinct from pediatric MB in terms of genomic aberrations and their impact on clinical outcomes.
  • Therefore, adult MBs require age-specific risk stratification models.
  • [MeSH-major] Cerebellar Neoplasms / genetics. Chromosome Aberrations. Medulloblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. Proto-Oncogene Proteins c-myc / genetics
  • [MeSH-minor] Adolescent. Adult. Algorithms. Biomarkers, Tumor / genetics. Carcinoma, Large Cell / classification. Carcinoma, Large Cell / genetics. Carcinoma, Large Cell / metabolism. Child. Child, Preschool. Chromosomes, Human, Pair 10 / genetics. Chromosomes, Human, Pair 17 / genetics. Chromosomes, Human, Pair 6 / genetics. Comparative Genomic Hybridization. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Infant. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Prognosis. Risk Assessment. Tissue Array Analysis. Young Adult. beta Catenin / genetics

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  • (PMID = 20479417.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYC protein, human; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin
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83. Lasky JL 3rd, Choe M, Nakano I: Cancer stem cells in pediatric brain tumors. Curr Stem Cell Res Ther; 2009 Dec;4(4):298-305
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer stem cells in pediatric brain tumors.
  • Although recent studies have focused on molecular mechanisms that underlie the initiation and progression of adult glioblastoma multiforme (GBM), these tumors differ phenotypically and at a molecular level from pediatric brain tumors.
  • Recent investigations have identified a stem cell population, termed "brain tumor stem cells" (BTSC) within the heterogeneous cell populations that comprise malignant brain tumors which may be partly responsible for the resistance to current therapies.
  • These have been identified in several pediatric tumors including medulloblastoma, ependymomas, and malignant gliomas.
  • By exploiting molecular differences present within these heterogeneous populations of brain tumor cells, we may be able to achieve specific eradication of BTSC and long-lasting remissions, while causing less toxicity to normal tissues.
  • In this review, we describe the issues surrounding the identification and characterization of BTSC, the molecular biology of BTSC for different pediatric brain tumors, and suggest future avenues for the development of treatments for this devastating disease.
  • [MeSH-major] Brain Neoplasms / pathology. Ependymoma / pathology. Medulloblastoma / pathology. Neoplastic Stem Cells / pathology. Optic Nerve Glioma / pathology
  • [MeSH-minor] Adult Stem Cells / pathology. Biomarkers / metabolism. Cell Differentiation. Chemotherapy, Adjuvant. Child. Humans. Surgical Procedures, Operative


84. Takei H, Bhattacharjee MB, Rivera A, Dancer Y, Powell SZ: New immunohistochemical markers in the evaluation of central nervous system tumors: a review of 7 selected adult and pediatric brain tumors. Arch Pathol Lab Med; 2007 Feb;131(2):234-41
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  • [Title] New immunohistochemical markers in the evaluation of central nervous system tumors: a review of 7 selected adult and pediatric brain tumors.
  • CONTEXT: Immunohistochemistry (IHC) has become an important tool in the diagnosis of brain tumors.
  • We discuss (1) placental alkaline phosphatase, c-Kit, and OCT4 for germinoma, (2) alpha-inhibin and D2-40 for capillary hemangioblastoma, (3) phosphohistone-H3 (PHH3), MIB-1/Ki-67, and claudin-1 for meningioma, (4) PHH3, MIB-1/Ki-67, and p53 for astrocytoma, (5) synaptophysin, microtubule-associated protein 2, neurofilament protein, and neuronal nuclei for medulloblastoma, (6) INI1 for atypical teratoid/rhabdoid tumor, and (7) epithelial membrane antigen for ependymoma.
  • All the markers presented here are used mainly for supporting or confirming the diagnosis, with the exception of the proliferation markers (MIB-1/Ki-67 and PHH3), which are primarily used to support grading and are reportedly associated with prognosis in certain categories of brain tumors.
  • In addition, IHC is also of great help in predicting the prognosis for certain brain tumors.
  • [MeSH-minor] Adult. Antibodies. Astrocytoma / diagnosis. Astrocytoma / metabolism. Child. Diagnosis, Differential. Ependymoma / diagnosis. Ependymoma / metabolism. Germinoma / diagnosis. Germinoma / metabolism. Hemangioblastoma / diagnosis. Hemangioblastoma / metabolism. Humans. Medulloblastoma / diagnosis. Medulloblastoma / metabolism. Meningioma / diagnosis. Meningioma / metabolism. Rhabdoid Tumor / diagnosis. Rhabdoid Tumor / metabolism

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  • (PMID = 17284108.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers, Tumor
  • [Number-of-references] 96
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85. Hänninen MM, Haapasalo J, Haapasalo H, Fleming RE, Britton RS, Bacon BR, Parkkila S: Expression of iron-related genes in human brain and brain tumors. BMC Neurosci; 2009;10:36
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  • [Title] Expression of iron-related genes in human brain and brain tumors.
  • Although the expression of genes involved in normal iron balance has been intensively studied in other tissues, little is known about their expression in the brain.
  • We investigated the mRNA levels of hepcidin (HAMP), HFE, neogenin (NEO1), transferrin receptor 1 (TFRC), transferrin receptor 2 (TFR2), and hemojuvelin (HFE2) in normal human brain, brain tumors, and astrocytoma cell lines.
  • The specimens included 5 normal brain tissue samples, 4 meningiomas, one medulloblastoma, 3 oligodendrocytic gliomas, 2 oligoastrocytic gliomas, 8 astrocytic gliomas, and 3 astrocytoma cell lines.
  • Notable findings include high expression of transferrin receptor 1 in the hippocampus and medulla oblongata compared to other brain regions, low expression of HFE in normal brain with elevated HFE expression in meningiomas, and absence of hepcidin mRNA in astrocytoma cell lines despite expression in normal brain and tumor specimens.
  • CONCLUSION: These results indicate that several iron-related genes are expressed in normal brain, and that their expression may be dysregulated in brain tumors.
  • [MeSH-major] Brain / metabolism. Brain Neoplasms / metabolism. Gene Expression Regulation, Neoplastic / physiology. Histocompatibility Antigens Class I / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / genetics. Antigens, CD / metabolism. Antimicrobial Cationic Peptides / genetics. Antimicrobial Cationic Peptides / metabolism. Astrocytoma / genetics. Astrocytoma / metabolism. Cell Line, Tumor. Female. GPI-Linked Proteins. Hepcidins. Humans. Male. Meningioma / genetics. Meningioma / metabolism. Middle Aged. Oligodendroglioma / genetics. Oligodendroglioma / metabolism. RNA, Messenger / analysis. Receptors, Transferrin / genetics. Receptors, Transferrin / metabolism. Statistics, Nonparametric. Young Adult

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  • [Cites] Histochem Cell Biol. 2001 Mar;115(3):195-203 [11326747.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G590-4 [16537971.001]
  • [Cites] Clin Cancer Res. 2001 Aug;7(8):2213-21 [11489794.001]
  • [Cites] J Natl Cancer Inst. 2001 Sep 5;93(17):1337-43 [11535709.001]
  • [Cites] Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 [12184808.001]
  • [Cites] J Clin Invest. 2002 Oct;110(7):1037-44 [12370282.001]
  • [Cites] Biometals. 2003 Mar;16(1):63-75 [12572665.001]
  • [Cites] Blood. 2003 Aug 1;102(3):783-8 [12663437.001]
  • [Cites] Brain Res Bull. 2003 Aug 30;61(4):365-74 [12909279.001]
  • [Cites] Nat Rev Mol Cell Biol. 2004 May;5(5):343-54 [15122348.001]
  • [Cites] Nat Rev Neurosci. 2004 Nov;5(11):863-73 [15496864.001]
  • [Cites] J Neurosurg. 1990 Jun;72(6):941-5 [2159987.001]
  • [Cites] Nat Genet. 1996 Aug;13(4):399-408 [8696333.001]
  • [Cites] J Comp Neurol. 1996 Nov 25;375(4):675-92 [8930792.001]
  • [Cites] J Neurol Sci. 2004 Dec 15;227(1):27-33 [15546588.001]
  • [Cites] Science. 2004 Dec 17;306(5704):2090-3 [15514116.001]
  • [Cites] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078.001]
  • [Cites] Dev Comp Immunol. 2005;29(11):939-50 [15935472.001]
  • [Cites] J Biol Chem. 2005 Oct 7;280(40):33885-94 [16103117.001]
  • [Cites] BMC Neurol. 2006;6:24 [16824219.001]
  • [Cites] J Neurosci Res. 2006 Sep;84(4):790-800 [16933319.001]
  • [Cites] J Alzheimers Dis. 2006 Nov;10(2-3):215-22 [17119289.001]
  • [Cites] J Alzheimers Dis. 2006 Nov;10(2-3):267-76 [17119292.001]
  • [Cites] J Histochem Cytochem. 2007 Jan;55(1):85-96 [16982849.001]
  • [Cites] Eur J Haematol. 2007 Jan;78(1):1-10 [17042775.001]
  • [Cites] J Clin Invest. 2007 Jul;117(7):1926-32 [17557118.001]
  • [Cites] Retina. 2007 Oct;27(8):997-1003 [18040235.001]
  • [Cites] Blood. 2008 Jan 15;111(2):924-31 [17938254.001]
  • [Cites] Biochemistry. 2008 Apr 8;47(14):4237-45 [18335997.001]
  • [Cites] Cell Metab. 2008 Apr;7(4):288-90 [18396134.001]
  • [Cites] J Biol Chem. 2008 Jun 20;283(25):17494-502 [18445598.001]
  • [Cites] Nat Rev Cancer. 2008 Dec;8(12):967-75 [18987634.001]
  • [Cites] BMC Cancer. 2005;5:154 [16324219.001]
  • [Cites] Brain Pathol. 2005 Oct;15(4):297-310 [16389942.001]
  • [Cites] J Clin Oncol. 2006 Mar 10;24(8):1253-65 [16525180.001]
  • [Cites] J Biol Chem. 2001 Mar 16;276(11):7806-10 [11113131.001]
  • (PMID = 19386095.001).
  • [ISSN] 1471-2202
  • [Journal-full-title] BMC neuroscience
  • [ISO-abbreviation] BMC Neurosci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antimicrobial Cationic Peptides; 0 / CD71 antigen; 0 / GPI-Linked Proteins; 0 / HAMP protein, human; 0 / HFE protein, human; 0 / HFE2 protein, human; 0 / Hepcidins; 0 / Histocompatibility Antigens Class I; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Receptors, Transferrin; 0 / TFR2 protein, human; 0 / neogenin
  • [Other-IDs] NLM/ PMC2679039
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86. Merchant TE, Pollack IF, Loeffler JS: Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol; 2010 Jan;20(1):58-66
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  • [Title] Brain tumors across the age spectrum: biology, therapy, and late effects.
  • The clinical difference between brain tumors in adults and children is striking.
  • In this review of glioma, ependymoma, and medulloblastoma, we highlight the differences between adults and children, including the higher incidence of spinal cord ependymoma and supratentorial high-grade glioma in the adult and a higher incidence of medulloblastoma in the child.
  • An effort is underway to better characterize adult and pediatric brain tumors biologically with an emphasis on improving our understanding of tumor genesis, malignant transformation, and some of the similarities and differences between tumor types and their response to conventional therapy.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / therapy. Glioma / epidemiology. Glioma / therapy. Radiotherapy / adverse effects
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Child. Child, Preschool. Combined Modality Therapy / methods. Disease Progression. Ependymoma / epidemiology. Ependymoma / therapy. Humans. Incidence. Infant. Infant, Newborn. Medulloblastoma / epidemiology. Medulloblastoma / therapy. Radiation Injuries. Young Adult

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  • [Cites] Lancet Oncol. 2009 Mar;10(3):258-66 [19274783.001]
  • [Cites] Brain Pathol. 2009 Jan;19(1):81-90 [18452568.001]
  • [Cites] J Pathol. 2009 Jun;218(2):172-81 [19373855.001]
  • [Cites] Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2 [10981749.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):287-95 [10661334.001]
  • [Cites] J Neurooncol. 2009 Jul;93(3):343-8 [19142584.001]
  • [Cites] Histopathology. 2000 Nov;37(5):437-44 [11119125.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2002 May 1;53(1):52-7 [12007941.001]
  • [Cites] J Pathol. 2002 Jun;197(2):238-44 [12015749.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2002 Nov 1;54(3):855-60 [12377339.001]
  • [Cites] Neurosurgery. 2003 Sep;53(3):544-53; discussion 554-5 [12943571.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):755-61 [14529781.001]
  • [Cites] N Engl J Med. 1993 Jun 17;328(24):1725-31 [8388548.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):978-86 [15758008.001]
  • [Cites] J Neurosurg. 2005 Apr;102(4):629-36 [15871504.001]
  • [Cites] J Clin Oncol. 2005 Dec 1;23(34):8853-62 [16314645.001]
  • [Cites] J Neurooncol. 2006 Feb;76(3):313-9 [16200343.001]
  • [Cites] Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2070-9 [16609018.001]
  • [Cites] J Clin Oncol. 2006 Sep 1;24(25):4202-8 [16943538.001]
  • [Cites] J Clin Oncol. 2007 Feb 20;25(6):682-9 [17308273.001]
  • [Cites] Brain Pathol. 2007 Apr;17(2):146-50 [17388945.001]
  • [Cites] J Clin Oncol. 2007 Apr 1;25(10):1196-208 [17401009.001]
  • [Cites] Brain. 2007 May;130(Pt 5):1338-49 [17449478.001]
  • [Cites] Neurochirurgie. 2007 Jun;53(2-3 Pt 1):66-75 [17475290.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):782-7 [17892918.001]
  • [Cites] J Clin Oncol. 2009 Aug 1;27(22):3691-7 [19581535.001]
  • [Cites] J Clin Oncol. 2009 Aug 1;27(22):3598-604 [19581536.001]
  • [Cites] J Neurooncol. 2009 Sep;94(3):391-8 [19330288.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):496-503 [19464817.001]
  • [Cites] Childs Nerv Syst. 2009 Oct;25(10):1261-8 [19373477.001]
  • [Cites] Cancer. 2008 Apr 1;112(7):1568-74 [18278809.001]
  • [Cites] J Clin Invest. 2008 May;118(5):1739-49 [18398503.001]
  • [Cites] Arch Pathol Lab Med. 2008 Jun;132(6):993-1007 [18517285.001]
  • [Cites] J Clin Oncol. 2008 Aug 20;26(24):3965-70 [18711186.001]
  • [Cites] Curr Opin Neurol. 2008 Dec;21(6):754-61 [18989122.001]
  • [Cites] J Clin Oncol. 2009 Apr 1;27(10):1627-36 [19255330.001]
  • (PMID = 19959032.001).
  • [ISSN] 1532-9461
  • [Journal-full-title] Seminars in radiation oncology
  • [ISO-abbreviation] Semin Radiat Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
  • [Other-IDs] NLM/ NIHMS425593; NLM/ PMC3529408
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87. Karkouri M, Zafad S, Khattab M, Benjaafar N, El Kacemi H, Sefiani S, Kettani F, Dey S, Soliman AS: Epidemiologic profile of pediatric brain tumors in Morocco. Childs Nerv Syst; 2010 Aug;26(8):1021-7
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  • [Title] Epidemiologic profile of pediatric brain tumors in Morocco.
  • INTRODUCTION: Brain tumors are the most common solid tumors diagnosed among children below 15 years worldwide.
  • However, little is known about the profile of pediatric brain tumors in Africa.
  • The purpose of this study was to further elaborate the epidemiological profile of pediatric brain tumors in Africa, specifically Morocco.
  • METHODS: A retrospective review was conducted of all patients with primary brain tumors in the age group 0-19 years, from 2003 to 2007, from multiple centers in two cities of Rabat and Casablanca, Morocco.
  • Descriptive epidemiologic profiles were created for the patients by age, sex, and histological subtypes of brain tumors.
  • RESULTS: Overall medulloblastoma was the most common brain tumor (34.5%), followed by pilocytic astrocytoma (17.3%) and diffuse astrocytoma grade 2 (12.5%).
  • Brain tumors occurred most commonly in 5-9-year age group followed by 10-14-year age group with the former being more common among males and the latter being more common among females.
  • We also found medulloblastoma to be the most common brain tumor in the 0-14-year-olds.
  • CONCLUSIONS: In this rare study focused on pediatric brain tumors in Morocco, most of the findings were consistent with past studies from other parts of the world.
  • However, we found medulloblastoma to be the most common pediatric brain tumor followed by astrocytoma.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / pathology
  • [MeSH-minor] Adolescent. Age Distribution. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Morocco / epidemiology. Retrospective Studies. Young Adult

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  • (PMID = 20179946.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA112383; United States / NCI NIH HHS / CA / R25 CA112383
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Other-IDs] NLM/ NIHMS649757; NLM/ PMC4276037
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88. Bowers DC, Adhikari S, El-Khashab YM, Gargan L, Oeffinger KC: Survey of long-term follow-up programs in the United States for survivors of childhood brain tumors. Pediatr Blood Cancer; 2009 Dec 15;53(7):1295-301
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  • [Title] Survey of long-term follow-up programs in the United States for survivors of childhood brain tumors.
  • INTRODUCTION: Despite recognition that childhood brain tumor survivors often suffer multiple late effects following therapy, little is known regarding the long-term follow-up (LTFU) programs for these patients.
  • Institutions were asked about the size of their brain tumor program, activities of the LTFU programs and perceived barriers to follow-up.
  • Institutions with a neuro-oncology LTFU clinic were more likely to use neuro-psychological testing following radiation therapy (P = 0.001), have longer duration of continued surveillance imaging (P = 0.02), use growth hormone replacement for medulloblastoma survivors (P < 0.001) and continue the use of growth hormone into adulthood (P = 0.05) than those with a general pediatric oncology program.
  • Perceived barriers to care of brain tumor survivors included limited access and lack of insurance (32.1%), lack of funding or dedicated time for providers (22.9%), patients' uncertainty about need to follow-up (20.6%), and patients' desire to not be followed in a pediatric cancer program (12.2%).
  • CONCLUSIONS: Considerable variation exists across institutions in the United States in the delivery of follow-up care for survivors of childhood brain tumors.
  • We encourage additional investigation to better define and implement optimal follow-up care for childhood brain tumor survivors.
  • [MeSH-major] Aftercare / organization & administration. Ambulatory Care / organization & administration. Brain Neoplasms. Oncology Service, Hospital / organization & administration. Outpatient Clinics, Hospital / organization & administration. Survivors
  • [MeSH-minor] Adult. Brain Diseases / etiology. Child. Chronic Disease. Cranial Irradiation / adverse effects. Data Collection. Dwarfism, Pituitary / etiology. Dwarfism, Pituitary / prevention & control. Female. Follow-Up Studies. Human Growth Hormone / administration & dosage. Human Growth Hormone / therapeutic use. Humans. Insurance Benefits. Male. Medulloblastoma / complications. Neuropsychological Tests. Patient Participation. Radiation Injuries / drug therapy. Radiation Injuries / etiology. Societies, Medical. United States / epidemiology

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  • (PMID = 19688835.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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89. van den Berkmortel F, Gidding C, De Kanter M, Punt CJ: Severe encephalopathy after high-dose chemotherapy with autologous stem cell support for brain tumours. Anticancer Res; 2006 Jan-Feb;26(1B):729-33
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  • [Title] Severe encephalopathy after high-dose chemotherapy with autologous stem cell support for brain tumours.
  • Recurrent medulloblastoma carries a poor prognosis.
  • A 21-year-old woman with recurrent medulloblastoma after previous chemotherapy and radiotherapy is presented.
  • Possible causative factors are discussed and central nervous system toxicity by high-dose chemotherapy in brain tumour patients is reviewed.
  • These data strongly support a systematic long-term follow-up of brain tumour patients treated with high-dose chemotherapy with emphasis on neurocognitive function tests.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Brain Neoplasms / drug therapy. Medulloblastoma / drug therapy. Neurotoxicity Syndromes / etiology. Stem Cell Transplantation
  • [MeSH-minor] Adult. Combined Modality Therapy. Dose-Response Relationship, Drug. Female. Humans. Transplantation, Autologous

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  • (PMID = 16739345.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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90. Deorah S, Lynch CF, Sibenaller ZA, Ryken TC: Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus; 2006;20(4):E1
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  • [Title] Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001.
  • OBJECT: An increasing incidence of brain cancer has been reported for the last three decades.
  • In this study of brain cancer incidence and patient survival in the US, the authors attempt to update information on trends by examining data provided by the Surveillance, Epidemiology, and End Results (SEER) Program.
  • METHODS: Population-based data from the SEER Program were used to calculate the incidence of and survival rates for people with brain cancer.
  • The approximate Poisson method was used to calculate relative risks for brain cancer and to determine a 95% confidence interval.
  • The relative risks of brain cancer were 1.48 for men compared with women, 3.18 for elderly persons compared with young adults, 1.86 for Caucasian patients compared with African-American patients, and 1.35 for those in metropolitan counties compared with those in nonmetropolitan counties.
  • The incidence of brain cancer increased until 1987, when the annual percentage of change reversed direction, decreasing from 1.68 to 20.44%.
  • Rising trends were noticed for glioblastoma multiforme (GBM), oligodendroglioma, anaplastic astrocytoma, medulloblastoma, and mixed glioma, and falling trends were observed for astrocytoma not otherwise specified and malignant glioma.
  • CONCLUSIONS: Increased risk of brain cancer is associated with being male, Caucasian, elderly, and residing in a metropolitan county.
  • The incidence rate of brain cancer in the US is gradually declining, but the rising trend of GBM combined with its poor survival rate is disconcerting and needs further exploration.
  • [MeSH-major] Astrocytoma / epidemiology. Brain Neoplasms / epidemiology. Glioblastoma / epidemiology. Glioma / epidemiology. Medulloblastoma / epidemiology. Oligodendroglioma / epidemiology. Population Surveillance
  • [MeSH-minor] Adult. Age Distribution. Aged. Cohort Studies. Continental Population Groups / statistics & numerical data. Female. Humans. Incidence. Male. Middle Aged. Risk Factors. Rural Population / statistics & numerical data. SEER Program / statistics & numerical data. Sex Distribution. Survival Rate / trends. United States / epidemiology. Urban Population / statistics & numerical data

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  • (PMID = 16709014.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Spreafico F, Gandola L, Marchianò A, Simonetti F, Poggi G, Adduci A, Clerici CA, Luksch R, Biassoni V, Meazza C, Catania S, Terenziani M, Musumeci R, Fossati-Bellani F, Massimino M: Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors. Int J Radiat Oncol Biol Phys; 2008 Mar 15;70(4):1011-9
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  • [Title] Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors.
  • PURPOSE: Brain necrosis or other subacute iatrogenic reactions has been recognized as a potential complication of radiotherapy (RT), although the possible synergistic effects of high-dose chemotherapy and RT might have been underestimated.
  • METHODS AND MATERIALS: We reviewed the clinical and radiologic data of 49 consecutive children with malignant brain tumors treated with high-dose thiotepa and autologous hematopoietic stem cell rescue, preceded or followed by RT.
  • RESULTS: Of the 49 children, 18 (6 of 25 with high-grade gliomas and 12 of 24 with primitive neuroectodermal tumors) had abnormal brain MRI findings occurring a median of 8 months (range, 2-39 months) after RT and beginning to regress a median of 13 months (range, 2-26 months) after onset.
  • [MeSH-major] Antineoplastic Agents, Alkylating / adverse effects. Brain. Brain Neoplasms. Glioma. Neuroectodermal Tumors, Primitive. Thiotepa / adverse effects
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Cognition / drug effects. Cognition / radiation effects. Combined Modality Therapy / adverse effects. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Infant. Intelligence / drug effects. Intelligence / radiation effects. Magnetic Resonance Imaging. Male. Medulloblastoma / drug therapy. Medulloblastoma / radiotherapy

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  • (PMID = 17904307.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 905Z5W3GKH / Thiotepa
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92. Barone G, Maurizi P, Tamburrini G, Riccardi R: Role of temozolomide in pediatric brain tumors. Childs Nerv Syst; 2006 Jul;22(7):652-61
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  • [Title] Role of temozolomide in pediatric brain tumors.
  • TMZ is able to cross the blood brain barrier and is stable at gastric acid pH so it has almost 100% oral bioavailability and is rapidly absorbed after it is taken orally.
  • TEMOZOLOMIDE IN CANCER PATIENTS: On the basis of the relatively safe toxicity and the findings achieved in adult malignant gliomas, phase I and II clinical trials were set up to evaluate the opportunity of using this novel drug in pediatric cancer, too.
  • In this review, we evaluate the antitumor activity of TMZ against high-grade gliomas, low-grade-gliomas, and medulloblastoma/primitive neuroectodermal tumors analyzing several phases I and II clinical trials in children.
  • CONCLUSIONS: In spite of the poor activity of TMZ against pediatric brain tumors, the use of the drug in combination with other compounds should be evaluated in phases I and II clinical trials.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Pediatrics

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  • [Cites] J Pediatr Hematol Oncol. 2003 May;25(5):372-8 [12759623.001]
  • [Cites] Br J Cancer. 2004 Aug 2;91(3):425-9 [15266331.001]
  • [Cites] J Clin Oncol. 2002 Dec 15;20(24):4684-91 [12488414.001]
  • [Cites] Br J Cancer. 1996 Feb;73(4):482-90 [8595163.001]
  • [Cites] Cancer Res. 1984 May;44(5):1772-5 [6713381.001]
  • [Cites] Br J Cancer. 1992 Feb;65(2):287-91 [1739631.001]
  • [Cites] Br J Cancer. 1998 Sep;78(5):652-61 [9744506.001]
  • [Cites] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):118-31 [15313584.001]
  • [Cites] J Clin Oncol. 1999 Sep;17 (9):2762-71 [10561351.001]
  • [Cites] J Clin Oncol. 1999 May;17 (5):1516-25 [10334539.001]
  • [Cites] Clin Cancer Res. 2000 Mar;6(3):998-1007 [10741727.001]
  • [Cites] Cancer Chemother Pharmacol. 2003 Dec;52(6):459-64 [13680160.001]
  • [Cites] Cancer Chemother Pharmacol. 1997;40(6):484-8 [9332462.001]
  • [Cites] Br J Cancer. 1996 Oct;74(7):1030-6 [8855970.001]
  • [Cites] Int J Health Serv. 2002;32(4):669-707 [12456121.001]
  • [Cites] J Clin Oncol. 2003 Feb 15;21(4):646-51 [12586801.001]
  • [Cites] J Neurooncol. 2003 Feb;61(3):203-7 [12675312.001]
  • [Cites] Clin Cancer Res. 2000 Oct;6(10 ):4110-8 [11051264.001]
  • [Cites] Cancer Res. 1987 Nov 15;47(22):5846-52 [3664486.001]
  • [Cites] J Clin Oncol. 1998 Sep;16(9):3037-43 [9738573.001]
  • [Cites] J Clin Oncol. 1995 Apr;13(4):910-3 [7707118.001]
  • [Cites] Lancet Oncol. 2001 Sep;2(9):552-60 [11905710.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jun 1;47(3):779-84 [10837964.001]
  • [Cites] J Clin Oncol. 2000 Apr;18(7):1481-91 [10735896.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10 ):997-1003 [15758010.001]
  • [Cites] Cancer. 2005 Jan 1;103(1):133-9 [15565574.001]
  • [Cites] J Med Chem. 1984 Feb;27(2):196-201 [6694168.001]
  • [Cites] J Neurooncol. 2004 Jan;66(1-2):203-8 [15015788.001]
  • [Cites] Childs Nerv Syst. 2005 Jun;21(6):477-81 [15378329.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10 ):987-96 [15758009.001]
  • [Cites] Invest New Drugs. 1998;16(1):77-9 [9740547.001]
  • (PMID = 16565851.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; YF1K15M17Y / temozolomide
  • [Number-of-references] 31
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93. Lindsey JC, Lusher ME, Strathdee G, Brown R, Gilbertson RJ, Bailey S, Ellison DW, Clifford SC: Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours. Int J Cancer; 2006 Jan 15;118(2):346-52
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  • [Title] Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours.
  • We examined the status of MCJ in intracranial primitive neuroectodermal tumours [PNETs, comprising cerebellar PNETs (medulloblastomas) and supratentorial PNETs (stPNETs)] and ependymomas, together representing the most common malignant brain tumours of childhood.
  • Evidence of MCJ hypermethylation was found in all 3 tumour types [medulloblastomas, 3/9 (33%) cell lines, 2/28 (7%) primary tumours; stPNETs, 2/2 (100%) cell lines, 3/10 (30%) primary tumours; and ependymomas, 2/20 (10%) primary tumours] but not in nonneoplastic brain tissues (n = 11), indicating that MCJ methylation is a tumour-specific event.
  • Extensive methylation patterns were associated with the methylation-dependent transcriptional silencing of MCJ in medulloblastoma and stPNET cell lines.
  • These data indicate that epigenetic inactivation of MCJ may play a role in the development of a range of paediatric brain tumour types, and its role in disease pathogenesis and chemotherapeutic resistance should now be investigated further.
  • [MeSH-major] Brain Neoplasms / genetics. Ependymoma / genetics. Epigenesis, Genetic. HSP40 Heat-Shock Proteins / biosynthesis. Membrane Proteins / biosynthesis. Neuroectodermal Tumors, Primitive / genetics
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Child, Preschool. DNA Methylation. Female. Gene Expression Profiling. Gene Silencing. Humans. Male. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16049974.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNAJC1 protein, human; 0 / HSP40 Heat-Shock Proteins; 0 / Membrane Proteins
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94. Malakootian M, Mowla SJ, Saberi H, Asadi MH, Atlasi Y, Shafaroudi AM: Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors. Mol Carcinog; 2010 Sep;49(9):818-25
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  • [Title] Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors.
  • In the present study, we have examined the expression of NS and its spliced variants in various brain tumors.
  • Total RNA was extracted from 59 brain tumor samples, and the expression of different NS spliced variants was measured by semi-quantitative RT-PCR.
  • The subcellular distribution of NS protein in brain tumors was further examined by immunohistochemistry.
  • Furthermore, to decipher the potential involvement of NS in brain tumorogenesis, its expression was knocked-down by means of RNA interference (RNAi) in two malignant glioma (U-87MG and A172), one astrocytoma (1321N1) and one medulloblastoma (DAOY) cell lines.
  • Our data revealed that NS and its variants are widely expressed in different types of brain tumors.
  • All in all, our data suggest a potential role for NS in tumorogenesis of brain cancers.
  • [MeSH-major] Astrocytoma / metabolism. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Glioma / metabolism
  • [MeSH-minor] Adult. Brain / metabolism. Cell Cycle / genetics. Cell Line. Cell Proliferation. Female. Humans. Immunohistochemistry. Male. Medulloblastoma / genetics. Medulloblastoma / metabolism. Medulloblastoma / pathology. Middle Aged. Proteins / genetics. Proteins / metabolism. RNA Interference. RNA Splicing. RNA, Small Interfering / genetics. RNA, Small Interfering / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Stem Cells / metabolism. Stem Cells / pathology

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  • [Copyright] 2010 Wiley-Liss, Inc.
  • (PMID = 20572164.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins; 0 / RNA, Small Interfering
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95. Bonner MJ, Hardy KK, Willard VW, Anthony KK, Hood M, Gururangan S: Social functioning and facial expression recognition in survivors of pediatric brain tumors. J Pediatr Psychol; 2008 Nov-Dec;33(10):1142-52
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  • [Title] Social functioning and facial expression recognition in survivors of pediatric brain tumors.
  • OBJECTIVE: To assess social functioning and facial expression recognition skill in survivors of pediatric brain tumors (BT) as compared to children with juvenile rheumatoid arthritis (JRA).
  • RESULTS: After controlling for estimated IQ, survivors of BT made significantly more errors interpreting adult facial expressions as compared to children with JRA.
  • [MeSH-major] Brain Damage, Chronic / psychology. Brain Neoplasms / psychology. Cognition Disorders / psychology. Emotions. Facial Expression. Pattern Recognition, Visual. Socialization. Survivors / psychology
  • [MeSH-minor] Adolescent. Arthritis, Juvenile / psychology. Astrocytoma / psychology. Cerebellar Neoplasms / psychology. Child. Ependymoma / psychology. Female. Humans. Intelligence. Male. Medulloblastoma / psychology. Personal Construct Theory. Social Behavior Disorders / diagnosis. Social Behavior Disorders / psychology

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  • (PMID = 18390896.001).
  • [ISSN] 1465-735X
  • [Journal-full-title] Journal of pediatric psychology
  • [ISO-abbreviation] J Pediatr Psychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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96. Han YG, Alvarez-Buylla A: Role of primary cilia in brain development and cancer. Curr Opin Neurobiol; 2010 Feb;20(1):58-67
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  • [Title] Role of primary cilia in brain development and cancer.
  • Recent studies show that this tiny projection plays important roles in brain development and diseases.
  • Ciliary mutant mice show defects in brain patterning, progenitor proliferation, and specification of adult neural stem cells.
  • Primary cilia also have dual opposing functions in the development of brain tumors.
  • Understanding the multifaceted roles that primary cilia have in brain development will provide important insights into the mechanism of brain development and diseases.

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  • [Copyright] 2009 Elsevier Ltd. All rights reserved.
  • [Cites] Cell Motil Cytoskeleton. 2002 Aug;52(4):195-201 [12112134.001]
  • [Cites] Cell. 2003 Jul 11;114(1):61-73 [12859898.001]
  • [Cites] Nature. 2003 Nov 6;426(6962):83-7 [14603322.001]
  • [Cites] J Cell Biol. 2004 Jun 7;165(5):673-83 [15184400.001]
  • [Cites] J Neurocytol. 1974 Oct;3(4):449-58 [4436691.001]
  • [Cites] Int J Dev Neurosci. 1987;5(1):43-51 [3503488.001]
  • [Cites] J Comp Neurol. 1990 Nov 15;301(3):365-81 [2262596.001]
  • [Cites] Neuron. 1999 Jan;22(1):103-14 [10027293.001]
  • [Cites] Curr Biol. 1999 Apr 22;9(8):445-8 [10226030.001]
  • [Cites] Development. 1999 Jun;126(14):3089-100 [10375501.001]
  • [Cites] Development. 1999 Aug;126(16):3561-71 [10409502.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11619-24 [10500226.001]
  • [Cites] Annu Rev Physiol. 2005;67:515-29 [15709968.001]
  • [Cites] Development. 2005 Jul;132(13):3103-11 [15930098.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11325-30 [16061793.001]
  • [Cites] J Biol Chem. 2005 Oct 14;280(41):34718-22 [16079132.001]
  • [Cites] Nature. 2005 Oct 13;437(7061):1018-21 [16136078.001]
  • [Cites] PLoS Genet. 2005 Oct;1(4):e53 [16254602.001]
  • [Cites] Development. 2005 Dec;132(23):5329-39 [16284123.001]
  • [Cites] Dev Biol. 2005 Nov 15;287(2):378-89 [16229832.001]
  • [Cites] Nat Genet. 2006 Jan;38(1):112-7 [16311594.001]
  • [Cites] Science. 2006 Feb 3;311(5761):629-32 [16410488.001]
  • [Cites] Bioinformatics. 2006 May 1;22(9):1031-5 [16443634.001]
  • [Cites] Hum Genet. 2006 Sep;120(2):171-8 [16783569.001]
  • [Cites] J Neurosci. 2006 Sep 6;26(36):9282-92 [16957084.001]
  • [Cites] Genes Dev. 2006 Nov 15;20(22):3161-73 [17114586.001]
  • [Cites] Front Biosci. 2007;12:1661-9 [17127412.001]
  • [Cites] J Cell Biol. 2007 Feb 12;176(4):483-95 [17283184.001]
  • [Cites] Cell. 2007 Jun 15;129(6):1201-13 [17574030.001]
  • [Cites] Development. 2007 Jul;134(14):2569-77 [17553904.001]
  • [Cites] Nat Genet. 2007 Jul;39(7):875-81 [17558409.001]
  • [Cites] Cell. 2007 Jun 29;129(7):1255-7 [17604715.001]
  • [Cites] Cell. 2007 Jun 29;129(7):1351-63 [17604723.001]
  • [Cites] Science. 2007 Jul 20;317(5836):372-6 [17641202.001]
  • [Cites] Cell. 2007 Aug 24;130(4):678-90 [17719545.001]
  • [Cites] J Neurosci. 2007 Sep 5;27(36):9780-9 [17804638.001]
  • [Cites] Curr Biol. 2007 Sep 18;17(18):1586-94 [17825558.001]
  • [Cites] J Comp Neurol. 2007 Dec 10;505(5):562-71 [17924533.001]
  • [Cites] Annu Rev Cell Dev Biol. 2007;23:345-73 [17506691.001]
  • [Cites] J Neurosci. 2007 Oct 24;27(43):11595-603 [17959802.001]
  • [Cites] Nat Neurosci. 2008 Mar;11(3):277-84 [18297065.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2853-8 [18287022.001]
  • [Cites] Int J Obes (Lond). 2008 Mar;32(3):407-12 [17895882.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4242-6 [18334641.001]
  • [Cites] Annu Rev Pathol. 2008;3:341-65 [18039127.001]
  • [Cites] Nat Genet. 2008 Apr;40(4):403-10 [18327258.001]
  • [Cites] Dev Biol. 2008 May 1;317(1):246-59 [18353302.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 May 6;105(18):6714-9 [18443298.001]
  • [Cites] PLoS Biol. 2008 Jul 22;6(7):e182 [18651793.001]
  • [Cites] Arch Gen Psychiatry. 2008 Sep;65(9):996-1006 [18762586.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13127-32 [18728187.001]
  • [Cites] Cell Stem Cell. 2008 Sep 11;3(3):265-78 [18786414.001]
  • [Cites] J Cell Biol. 2008 Nov 3;183(3):377-84 [18981227.001]
  • [Cites] J Neurosci. 2008 Nov 26;28(48):12887-900 [19036983.001]
  • [Cites] Dev Biol. 2009 Jan 1;325(1):24-32 [18930042.001]
  • [Cites] Am J Physiol Renal Physiol. 2009 Jan;296(1):F87-97 [18945824.001]
  • [Cites] Curr Top Dev Biol. 2008;85:23-61 [19147001.001]
  • [Cites] Hum Mol Genet. 2009 Apr 1;18(7):1323-31 [19150989.001]
  • [Cites] Nature. 2009 Apr 2;458(7238):651-4 [19242413.001]
  • [Cites] Cell. 2009 Apr 3;137(1):32-45 [19345185.001]
  • [Cites] Dev Biol. 2009 Aug 1;332(1):177-85 [19481538.001]
  • [Cites] Development. 2009 Sep;136(18):3089-98 [19700616.001]
  • [Cites] Exp Cell Res. 2009 Oct 1;315(16):2802-17 [19576885.001]
  • [Cites] Nat Genet. 2009 Sep;41(9):1027-31 [19668215.001]
  • [Cites] Nat Genet. 2009 Sep;41(9):1032-6 [19668216.001]
  • [Cites] Science. 2009 Aug 28;325(5944):1131-4 [19628819.001]
  • [Cites] PLoS One. 2009;4(8):e6839 [19718259.001]
  • [Cites] Nat Med. 2009 Sep;15(9):1062-5 [19701203.001]
  • [Cites] Nat Med. 2009 Sep;15(9):1055-61 [19701205.001]
  • [Cites] PLoS One. 2009;4(9):e6979 [19750222.001]
  • [Cites] Biochem Biophys Res Commun. 2009 Oct 30;388(4):757-62 [19703416.001]
  • [Cites] FASEB J. 2009 Oct;23(10):3289-97 [19470799.001]
  • [Cites] Dev Biol. 2009 Nov 1;335(1):166-78 [19732765.001]
  • [Cites] Curr Biol. 2009 Sep 15;19(17):1498-502 [19682908.001]
  • [Cites] Dev Biol. 2000 Jan 15;217(2):254-65 [10625551.001]
  • [Cites] Development. 2000 May;127(9):1799-813 [10751169.001]
  • [Cites] Science. 2001 Jun 15;292(5524):2041-50 [11375483.001]
  • (PMID = 20080044.001).
  • [ISSN] 1873-6882
  • [Journal-full-title] Current opinion in neurobiology
  • [ISO-abbreviation] Curr. Opin. Neurobiol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS028478; United States / NINDS NIH HHS / NS / NS28478; United States / NINDS NIH HHS / NS / R01 NS028478-17; United States / NICHD NIH HHS / HD / HD32116; United States / NICHD NIH HHS / HD / R37 HD032116-15; United States / NICHD NIH HHS / HD / R37 HD032116; United States / NINDS NIH HHS / NS / R37 NS028478; United States / NICHD NIH HHS / HD / R01 HD032116
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 77
  • [Other-IDs] NLM/ NIHMS164482; NLM/ PMC2829308
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97. Rollison DE, Utaipat U, Ryschkewitsch C, Hou J, Goldthwaite P, Daniel R, Helzlsouer KJ, Burger PC, Shah KV, Major EO: Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories. Int J Cancer; 2005 Feb 20;113(5):769-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories.
  • JC virus (JCV), BK virus (BKV) and simian virus 40 (SV40) may be associated with human brain tumors.
  • These polyomaviruses have been shown to induce brain tumors in experimentally infected animals.
  • Several studies have found polyomavirus genomic sequences in human brain tumor tissues by using polymerase chain reaction (PCR), while others have not.
  • To assess the role of polyomaviruses in human brain tumors and address inconsistencies of previous reports, we investigated the prevalence of viral sequences in a series of 225 brain tumor tissue specimens in 2 independent laboratories.
  • Nucleotide sequences for JCV, BKV and SV40 are rarely present in a large series of adult and pediatric brain tumors.
  • [MeSH-major] Brain Neoplasms / virology. Polyomavirus Infections / virology. Tumor Virus Infections / virology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. BK Virus / genetics. BK Virus / isolation & purification. Blotting, Southern. Child. Child, Preschool. DNA, Neoplasm / genetics. Female. Genome, Viral. Glioma / diagnosis. Glioma / genetics. Glioma / virology. Humans. Infant. JC Virus / genetics. JC Virus / isolation & purification. Male. Medulloblastoma / diagnosis. Medulloblastoma / genetics. Medulloblastoma / virology. Meningioma / diagnosis. Meningioma / genetics. Meningioma / virology. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / genetics. RNA, Viral / genetics. Reverse Transcriptase Polymerase Chain Reaction. Simian virus 40 / genetics. Simian virus 40 / isolation & purification

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  • [Copyright] (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15499616.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Viral
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98. Barnholtz-Sloan JS, Severson RK, Stanton B, Hamre M, Sloan AE: Pediatric brain tumors in non-Hispanics, Hispanics, African Americans and Asians: differences in survival after diagnosis. Cancer Causes Control; 2005 Jun;16(5):587-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric brain tumors in non-Hispanics, Hispanics, African Americans and Asians: differences in survival after diagnosis.
  • BACKGROUND: Racial differences in survival for children with brain tumors have not been well studied, particularly in Hispanics and Asians.
  • The objective of this study was to assess racial differences in survival of children with brain tumors, focusing on Hispanics, African Americans and Asians compared to Non-Hispanics.
  • METHODS: Subjects identified through the SEER Program were 2799 children, < or =19 years old at diagnosis, newly diagnosed between 1973 and 1996 with primary, malignant brain tumors.
  • [MeSH-major] Brain Neoplasms / mortality. Continental Population Groups / statistics & numerical data
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / ethnology. Astrocytoma / mortality. Astrocytoma / therapy. Child. Child, Preschool. Ependymoma / ethnology. Ependymoma / mortality. Ependymoma / therapy. Female. Humans. Infant. Infant, Newborn. Male. Medulloblastoma / ethnology. Medulloblastoma / mortality. Medulloblastoma / therapy. Proportional Hazards Models. SEER Program. Survival Analysis. United States / epidemiology

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  • (PMID = 15986114.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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99. Kremer P, Fardanesh M, Ding R, Pritsch M, Zoubaa S, Frei E: Intraoperative fluorescence staining of malignant brain tumors using 5-aminofluorescein-labeled albumin. Neurosurgery; 2009 Mar;64(3 Suppl):ons53-60; discussion ons60-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative fluorescence staining of malignant brain tumors using 5-aminofluorescein-labeled albumin.
  • OBJECTIVE: The newly developed conjugate 5-aminofluorescein (AFL)-human serum albumin (HSA) was investigated in a clinical trial for fluorescence-guided surgery of malignant brain tumors to assess its efficacy and tolerability.
  • Neither bleaching nor penetration of AFL-HSA into the surrounding brain edema or into necrotic tissue was seen.
  • CONCLUSION: Tumor fluorescence using AFL-HSA made fluorescence-guided brain tumor resection possible, demonstrating that albumin is a suitable carrier system for selective targeting of aminofluorescein into malignant gliomas.
  • [MeSH-major] Brain Neoplasms / pathology. Fluoresceins. Glioma / pathology. Serum Albumin
  • [MeSH-minor] Adult. Aged. Cell Proliferation. Female. Glioblastoma / pathology. Glioblastoma / surgery. Humans. Logistic Models. Magnetic Resonance Imaging. Male. Medulloblastoma / pathology. Medulloblastoma / surgery. Microscopy, Fluorescence. Middle Aged. Oligodendroglioma / pathology. Oligodendroglioma / surgery. Paraffin Embedding. Tissue Fixation

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  • (PMID = 19240573.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluoresceins; 0 / Serum Albumin; 3326-34-9 / 5-aminofluorescein
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100. Choudry Q, Patel HC, Gurusinghe NT, Evans DG: Radiation-induced brain tumours in nevoid basal cell carcinoma syndrome: implications for treatment and surveillance. Childs Nerv Syst; 2007 Jan;23(1):133-6
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  • [Title] Radiation-induced brain tumours in nevoid basal cell carcinoma syndrome: implications for treatment and surveillance.
  • INTRODUCTION: We report two cases of radiation-induced intracranial tumours after treatment for medulloblastoma presenting in children with nevoid basal cell carcinoma syndrome.
  • [MeSH-major] Astrocytoma / etiology. Brain Neoplasms / etiology. Cerebellar Neoplasms / radiotherapy. Medulloblastoma / radiotherapy. Neoplasms, Radiation-Induced. Radiotherapy / adverse effects
  • [MeSH-minor] Adolescent. Adult. Basal Cell Nevus Syndrome / complications. Basal Cell Nevus Syndrome / genetics. Basal Cell Nevus Syndrome / physiopathology. Female. Humans. Infant. Male

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  • [Cites] Br J Cancer. 1991 Nov;64(5):959-61 [1931625.001]
  • [Cites] J Clin Oncol. 1999 Mar;17(3):832-45 [10071274.001]
  • [Cites] Cancer. 2003 Aug 1;98(3):618-24 [12879481.001]
  • [Cites] Lancet Oncol. 2004 Jul;5(7):399-408 [15231246.001]
  • [Cites] Br J Cancer. 1997;76(2):141-5 [9231911.001]
  • [Cites] J Neurosurg. 1997 Feb;86(2):286-8 [9010431.001]
  • [Cites] J Neurosurg. 1999 Dec;91(6):971-7 [10584843.001]
  • [Cites] Br J Neurosurg. 1991;5(6):643-6 [1772613.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):269-79 [10661332.001]
  • [Cites] Lancet Oncol. 2004 Apr;5(4):209-18 [15050952.001]
  • [Cites] J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):268-71 [11464980.001]
  • [Cites] J Pediatr Hematol Oncol. 2001 Oct;23(7):431-6 [11878577.001]
  • [Cites] J Clin Oncol. 2004 Mar 15;22(6):984-93 [14970185.001]
  • (PMID = 16977487.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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