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1. Rogers CG, Blatt AM, Miles GE, Linehan WM, Pinto PA: Concurrent robotic partial adrenalectomy and extra-adrenal pheochromocytoma resection in a pediatric patient with von Hippel-Lindau disease. J Endourol; 2008 Jul;22(7):1501-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent robotic partial adrenalectomy and extra-adrenal pheochromocytoma resection in a pediatric patient with von Hippel-Lindau disease.
  • Laparoscopic partial adrenalectomy is a surgical option for select patients with hereditary pheochromocytoma.
  • We present a case of a pediatric patient with von Hippel-Lindau disease (VHL) and both an adrenal pheochromocytoma and an extra-adrenal pheochromocytoma, who underwent concurrent partial adrenalectomy and extra-adrenal pheochromocytoma resection utilizing robotic assistance.
  • To the best of our knowledge, this is the first report of partial adrenalectomy with concurrent extra-adrenal pheochromocytoma resection.

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  • [Cites] Surg Endosc. 2006 Jan;20(1):119-24 [16333534.001]
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  • (PMID = 18690816.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / Z01 SC006659-25
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS87493; NLM/ PMC2648969
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2. Rebai W, Kacem M, Jouini M, Bedioui H, Fterich F, Ayadi S, Daghfous A, Chebbi F, Makni A, Chouikh T, Ksantini R, Bensafta Z: Malignant extra-adrenal pheochromocytoma--a diagnostic dilemma. Tunis Med; 2010 Sep;88(9):684-5
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  • [Title] Malignant extra-adrenal pheochromocytoma--a diagnostic dilemma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Vena Cava, Inferior / pathology. Vena Cava, Inferior / surgery

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  • (PMID = 20812189.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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3. Nassar MI, de la Llana R, de Bonis E, Garrido P, Alarcó A, Méndez R, Martínez-Sanz R: Extra-adrenal pheochromocytoma involving the left atrium: an infrequent pathologic occurrence. J Thorac Cardiovasc Surg; 2006 Dec;132(6):1460-1
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  • [Title] Extra-adrenal pheochromocytoma involving the left atrium: an infrequent pathologic occurrence.
  • [MeSH-major] Heart Neoplasms / diagnosis. Pheochromocytoma / diagnosis

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  • (PMID = 17140976.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Iyer RB, Guo CC, Perrier N: Adrenal pheochromocytoma with surrounding brown fat stimulation. AJR Am J Roentgenol; 2009 Jan;192(1):300-1
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  • [Title] Adrenal pheochromocytoma with surrounding brown fat stimulation.
  • [MeSH-major] Adipose Tissue, Brown / radiography. Adipose Tissue, Brown / radionuclide imaging. Adrenal Gland Neoplasms / diagnosis. Fluorodeoxyglucose F18. Pheochromocytoma / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 19098214.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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5. Lallana Álvarez MJ, Rabanaque Hernández MJ: [Variability in the Use of New Drugs in a Primary Care District]. Rev Esp Salud Publica; 2005 Jun 01;79:379-389

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  • [Title] [Variability in the Use of New Drugs in a Primary Care District].
  • [Transliterated title] Variabilidad en la utilización de nuevos medicamentos en un área de atención primaria.
  • This study is aimed at ascertaining the degree to which pharmaceutical novelties are being used in one healthcare district in Zaragoza, describing which are those most used and the trend thereof over the course of time in addition to analyzing the characteristics of those centers associated with a greater use of these drugs.
  • The percentage of use of novelties throughout the first year these drugs were marketed at each primary care center was calculated, the characteristics of those centers associated with a greater degree of innovation having been analyzed.
  • The percentage of use of new drugs as compared to all of the drugs prescribed at the healthcare centers studied fell within the 0.3% -1.18% range.
  • In the analysis made by centers, the «per-patient expense» and the «consultations per physician» are positively correlated with a greater use of new drugs, whilst the percentage of retirees showed a reverse ratio.
  • CONCLUSIONS: A high degree of variability exists in the percentage of use of pharmaceutical novelties among the primary care centers.
  • The centers having the largest number of consultations per physician are those tending toward more readily incorporating these new drugs.

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  • (PMID = 28272386.001).
  • [ISSN] 2173-9110
  • [Journal-full-title] Revista espanola de salud publica
  • [ISO-abbreviation] Rev. Esp. Salud Publica
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Keywords] NOTNLM ; Drug utilization / Primary health care
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6. Kravarusic D, Pinto-Rojas A, Al-Assiri A, Sigalet D: Laparoscopic resection of extra-adrenal pheochromocytoma--case report and review of the literature in pediatric patients. J Pediatr Surg; 2007 Oct;42(10):1780-4
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  • [Title] Laparoscopic resection of extra-adrenal pheochromocytoma--case report and review of the literature in pediatric patients.
  • Surgery for pheochromocytoma differs from that of other tumors owing to the potential release of catecholamines, which may lead to severe intraoperative hemodynamic changes.
  • The present standard of care for resection of adrenal pheochromocytoma has become a laparoscopic approach for surgical excision.
  • Extra-adrenal pheochromocytoma is a very rare entity, especially in the pediatric age group; the utility of the laparoscopic approach is not established in this population.
  • We present a case report of a child with hormonally active extra-adrenal pheochromocytoma originating in the organ of Zuckerkandl that was resected laparoscopically.
  • We found the laparoscopic approach gave excellent exposure, allowing for proper identification of the tumor's origin and its relation to surrounding structures; a complete resection with excellent control of the feeding blood vessels was performed.
  • After our initial experience we can recommend laparoscopic exploration for similar cases of suspected extra-adrenal pheochromocytoma as an appropriate tool to identify extension of the disease and estimate resectability.
  • [MeSH-major] Abdominal Neoplasms / surgery. Laparoscopy / methods. Para-Aortic Bodies / pathology. Pheochromocytoma / surgery

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  • (PMID = 17923216.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic alpha-Antagonists; 0 / Catecholamines; XM03YJ541D / Prazosin
  • [Number-of-references] 32
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7. Kaji P, Carrasquillo JA, Linehan WM, Chen CC, Eisenhofer G, Pinto PA, Lai EW, Pacak K: The role of 6-[18F]fluorodopamine positron emission tomography in the localization of adrenal pheochromocytoma associated with von Hippel-Lindau syndrome. Eur J Endocrinol; 2007 Apr;156(4):483-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of 6-[18F]fluorodopamine positron emission tomography in the localization of adrenal pheochromocytoma associated with von Hippel-Lindau syndrome.
  • OBJECTIVE: [(123/131)I]metaiodobenzylguanidine (MIBG) scintigraphy is considered as the gold standard in the localization of pheochromocytoma.
  • However, this method has less optimal sensitivity for the detection of pheochromocytoma associated with von Hippel-Lindau (VHL).
  • Our preliminary results suggest that this is partially due to the low expression of cell membrane norepinephrine transporter system in VHL-related pheochromocytoma cells.
  • Recently, 6-[(18)F]fluorodopamine ([(18)F]DA) positron emission tomography (PET) has been introduced as a novel functional imaging modality with high sensitivity for pheochromocytoma.
  • Therefore, we investigated whether [(18)F]DA PET is more effective than [(123/131)I]MIBG scintigraphy in the diagnostic localization of VHL-related adrenal pheochromocytoma.
  • MATERIALS AND METHODS: In this study, we evaluated seven VHL patients in whom adrenal pheochromocytomas were confirmed by histopathology results.
  • Adrenal pheochromocytomas were localized using computed tomography (CT), magnetic resonance imaging (MRI), [(123/131)I]MIBG scintigraphy and [(18)F]DA PET.
  • RESULTS: [(18)F]DA PET localized pheochromocytoma in all the seven patients, as did in CT.
  • CONCLUSIONS: [(18)F]DA PET was found to show more promising results when compared with [(123/131)I]MIBG scintigraphy in the diagnostic localization of VHL-related adrenal pheochromocytoma, with a 100% rate of localization.
  • Thus, [(18)F]DA PET in conjunction with CT/MRI should be considered as an effective method for the proper localization of VHL-related adrenal pheochromocytoma.


8. de Souza F, Altenburg Odebrecht Curi Gismondi R, Henriques Cunha Neto S, de Mattos MA: Tako-tsubo-like cardiomyopathy and extra-adrenal pheochromocytoma: case report and literature review. Clin Res Cardiol; 2008 Jun;97(6):397-401
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  • [Title] Tako-tsubo-like cardiomyopathy and extra-adrenal pheochromocytoma: case report and literature review.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / diagnosis. Pheochromocytoma / diagnosis. Takotsubo Cardiomyopathy / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Electrocardiography. Female. Humans. Hypertension / etiology. Magnetic Resonance Imaging. Tomography, Emission-Computed

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  • (PMID = 18193368.001).
  • [ISSN] 1861-0692
  • [Journal-full-title] Clinical research in cardiology : official journal of the German Cardiac Society
  • [ISO-abbreviation] Clin Res Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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9. Mizuta E, Hamada T, Taniguchi S, Shimoyama M, Nawada T, Miake J, Kaetsu Y, Peili L, Ishiguro K, Ishiguro S, Igawa O, Shigemasa C, Hisatome I: Small extra-adrenal pheochromocytoma causing severe hypertension in an elderly patient. Hypertens Res; 2006 Aug;29(8):635-8
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  • [Title] Small extra-adrenal pheochromocytoma causing severe hypertension in an elderly patient.
  • We report the case of a 67-year-old woman with severe hypertension caused by an extra-adrenal pheochromocytoma.
  • The tumor was detected by 131I metaiodobenzylguanidine scintigraphy and it was found to be small (2 cm ø) by enhanced CT.
  • After the extirpation of the tumor, the blood pressure of the patient immediately normalized.
  • It should be taken into account that a small extra-adrenal pheochromocytoma can be one of the causes of secondary hypertension in elderly patients.
  • Since small extra-adrenal pheochromocytomas are difficult to detect, it is also important to perform suitable examinations to establish the diagnosis.
  • Furthermore, we emphasize the importance of an accurate diagnosis in elderly patients with pheochromocytoma, for they often have less symptomatology and more severe cardiovascular complications due to refractory hypertension than younger patients.
  • [MeSH-major] Duodenal Neoplasms / complications. Hypertension / etiology. Pheochromocytoma / complications


10. Kim S, Salibi N, Hardie AD, Xu J, Lim RP, Lee VS, Taouli B: Characterization of adrenal pheochromocytoma using respiratory-triggered proton MR spectroscopy: initial experience. AJR Am J Roentgenol; 2009 Feb;192(2):450-4
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  • [Title] Characterization of adrenal pheochromocytoma using respiratory-triggered proton MR spectroscopy: initial experience.
  • OBJECTIVE: The aim of our study was to evaluate the feasibility of respiratory-triggered proton single-voxel MR spectroscopy for the diagnosis of adrenal pheochromocytoma and to determine whether certain spectral resonances detected on single-voxel MR spectroscopy are specific for adrenal pheochromocytomas compared with adrenal adenomas.
  • CONCLUSION: Adrenal pheochromocytomas have a unique MR spectral signature, showing 6.8 ppm resonance that is not seen in adenomas.
  • This unique spectral signature may be attributed to the presence of catecholamines and catecholamine metabolites that are abundant in pheochromocytomas.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Magnetic Resonance Spectroscopy / methods. Pheochromocytoma / diagnosis
  • [MeSH-minor] Adrenocortical Adenoma / diagnosis. Adrenocortical Adenoma / metabolism. Adult. Aged. Catecholamines / metabolism. Feasibility Studies. Female. Humans. Image Interpretation, Computer-Assisted. Male. Middle Aged. Prospective Studies. Protons. Respiration

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  • (PMID = 19155409.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Protons
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11. Prichayudh S, Kritayakirana K, Snabboon T, Sriussadaporn S, Sriussadaporn S, Pak-art R, Sirimahachaiyakul P, Tsunoyama T, Capin A: An extra-adrenal pheochromocytoma of the organ of Zuckerkandl: report of a case. J Med Assoc Thai; 2009 Nov;92(11):1532-7
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  • [Title] An extra-adrenal pheochromocytoma of the organ of Zuckerkandl: report of a case.
  • The authors report a case of extra-adrenal pheochromocytoma of the organ of Zuckerkandl presenting with hypertension and an abdominal mass in a young adult.
  • Preoperative diagnosis was made by biochemical and imaging studies.
  • The operation to remove the tumor was successfully performed.
  • [MeSH-major] Pheochromocytoma / diagnosis. Pheochromocytoma / surgery
  • [MeSH-minor] Aorta, Abdominal / pathology. Contrast Media. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Para-Aortic Bodies / pathology. Radiopharmaceuticals. Tomography, Emission-Computed. Vena Cava, Inferior / pathology. Young Adult

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  • (PMID = 19938747.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals
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12. Methe H, Hinterseer M, Wilbert-Lampen U, Beckmann BM, Steinbeck G, Kääb S: Torsades de Pointes: a rare complication of an extra-adrenal pheochromocytoma. Hypertens Res; 2007 Dec;30(12):1263-6
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  • [Title] Torsades de Pointes: a rare complication of an extra-adrenal pheochromocytoma.
  • Pheochromocytoma is an infrequent secondary cause of arterial hypertension, often associated with paroxysmal headache, sweating, weight loss, and palpitations.
  • Cardiovascular complications of pheochromocytoma include sudden death, heart failure due to toxic cardiomyopathy, and hypertensive encephalopathy.
  • Here we report the case of a female with an acquired long-QT-syndrome as a rare complication of an extra-adrenal pheochromocytoma.
  • Diagnosis was made after sotalol-induced Torsades de Pointes.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Pheochromocytoma / complications. Torsades de Pointes / diagnosis. Torsades de Pointes / etiology

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  • (PMID = 18344633.001).
  • [ISSN] 0916-9636
  • [Journal-full-title] Hypertension research : official journal of the Japanese Society of Hypertension
  • [ISO-abbreviation] Hypertens. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Arrhythmia Agents; A6D97U294I / Sotalol
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13. Ercolino T, Taurino C, Sestini R, Bacca AV, Genuardi M, Mannelli M, Bernini GP: Malignant extra-adrenal pheochromocytoma caused by an SDHB intronic variation leading to a 54-bp deletion in exon 4. J Endocrinol Invest; 2009 Feb;32(2):111-4
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  • [Title] Malignant extra-adrenal pheochromocytoma caused by an SDHB intronic variation leading to a 54-bp deletion in exon 4.
  • In the last few years several papers have reported on the association between mutations of the genes encoding the structural (SDHC, SDHD) and catalytic (SDHB) subunits of succinate dehydrogenase and the occurrence of hereditary pheochromocytomas/paragangliomas (Pheo/PGL) syndromes.
  • We diagnosed a malignant extraadrenal Pheo in a 38-yr-old man with abdominal lesions; many areas of increased uptake at octreoscan scintigraphy in the skeleton indicated metastatic disease.
  • This finding indicates once again that SDHB mutations could predispose to malignant Pheo.
  • [MeSH-major] Abdominal Neoplasms / genetics. Pheochromocytoma / genetics. Succinate Dehydrogenase / genetics
  • [MeSH-minor] 3-Iodobenzylguanidine. Adult. Base Sequence. Fatal Outcome. Female. Gene Deletion. Humans. Male. Molecular Sequence Data. Neoplasm Metastasis. Pedigree. Radionuclide Imaging. Somatostatin / analogs & derivatives

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  • (PMID = 19411806.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 35MRW7B4AD / 3-Iodobenzylguanidine; 51110-01-1 / Somatostatin; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase; G083B71P98 / pentetreotide
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14. Ramacciotti C, Schneegans O, Lang H, Lindner V, Claria M, Moreau F, Chenard MP, Pinget M, Kessler L: [Diffuse uptake of brown fat on computed-tomography coupled positron emission tomoscintigraphy (PET-CT) for the exploration of extra-adrenal pheochromocytoma]. Ann Endocrinol (Paris); 2006 Mar;67(1):14-9
Hazardous Substances Data Bank. Norepinephrine .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diffuse uptake of brown fat on computed-tomography coupled positron emission tomoscintigraphy (PET-CT) for the exploration of extra-adrenal pheochromocytoma].
  • [Transliterated title] Hyperfixation diffuse de la graisse brune à la tomoscintigraphie par émission de positons couplée à la tomodensitométrie (TEP-TDM) dans l'exploration d'un phéochromocytome extra surrénalien.
  • We report an observation of strong bilateral uptake on a PET-CT scan compatible with activation of brown adipose tissue in a patient with extra-adrenal pheochromocytoma.
  • 18F-DG PET showed intensed uptake in the tumor mass together with intense, diffuse and bilateral uptake above and below the diaphragm.
  • Histological examination of the surgical specimen confirmed the diagnosis of extra-adrenal pheochromocytoma with an index of 13% cellular proliferation without cell atypia.
  • Bilateral spread of the radiotracer uptake was probably due to brown adipose tissue activation by excessive sympathetic stimulation induced by catecholamines released by the tumor.
  • [MeSH-major] Abdominal Neoplasms / metabolism. Adipose Tissue, Brown / metabolism. Pheochromocytoma / radiography. Pheochromocytoma / radionuclide imaging

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  • (PMID = 16596052.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] X4W3ENH1CV / Norepinephrine
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15. Shi BB, Li HZ, Chen C, Rong S, Fan H, Wen J, Li HJ: Differential diagnosis and laparoscopic treatment of adrenal pheochromocytoma and ganglioneuroma. Chin Med J (Engl); 2009 Aug 5;122(15):1790-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential diagnosis and laparoscopic treatment of adrenal pheochromocytoma and ganglioneuroma.
  • BACKGROUND: Adrenal ganglioneuroma is a rare adrenal pathogenic disease with difficult differential diagnosis from adrenal pheochromocytoma.
  • Currently, very limited literature is available to allow a differential diagnosis of these two conditions from each other.
  • This study aimed to evaluate the clinical profile, differential diagnosis and surgical treatments of both conditions.
  • METHODS: Clinical characteristics of 36 patients with adrenal pheocheomocytoma and 18 patients with adrenal ganglioneuroma were analyzed.
  • Neither (131)I-MIBG nor endocrine hormone tests were available in 9 cases of asymptomatic adrenal ganglioneuroma with tumor size less than 4 cm and there were negative findings from contrast enhanced CT scans.
  • The level of urine catecholamine of patients was compared by one-way analysis of variance.
  • RESULTS: Te mean age of patients in the adrenal ganglioneuroma group was 41.2 years (16 - 67 year) and in the adrenal pheochromocytoma patients 38 years (17 - 74 year).
  • Contrast enhanced CT showed that the foci were intensified in 5 cases (27.8%) of adrenal ganglioneuroma and there were obvious contrast indications in 30 (83.3%) of the pheochromocytoma.
  • Catecholamine levels in a 24-hour urine sample were normal in 4 patients with adrenal ganglioneuroma and increased in 36 (100%) cases with adrenal pheochromocytoma. (131)I-MIBG nuclear scan showed negative results in 4 patients (100%) with adrenal ganglioneuroma and positive results in 25 (96.2%) with adrenal pheochromocytom.
  • Laparoscopy for adrenal tumors was performed through a transperitoneal or retroperitoneal approach during a follow-up period of (43 +/- 6) months, and all cases survived well.
  • CONCLUSIONS: CT, urinary catecholamine and (131)I-MIBG are standard and efficient tools for differential diagnosis of adrenal ganglioneuroma from pheochromocytoma.
  • Laparoscopic surgery can be performed through a transperitoneal or retroperitoneal approach depending on the finding of CT scans.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / surgery. Ganglioneuroma / diagnosis. Ganglioneuroma / surgery. Laparoscopy / methods. Pheochromocytoma / diagnosis. Pheochromocytoma / surgery

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  • (PMID = 19781327.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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16. Cheng KH, Chu CS, Lai WT: Ventricular tachycardia and spontaneous rupture of an extra-adrenal pheochromocytoma case. Kaohsiung J Med Sci; 2005 May;21(5):245-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ventricular tachycardia and spontaneous rupture of an extra-adrenal pheochromocytoma case.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Pheochromocytoma / complications. Rupture, Spontaneous / etiology. Tachycardia, Ventricular / etiology
  • [MeSH-minor] Blood Pressure. Chromaffin Cells / pathology. Diagnosis, Differential. Electrocardiography. Female. Humans. Hypertension / etiology. Hypertension / physiopathology. Middle Aged. Syncope / etiology. Tomography, X-Ray Computed

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  • [CommentOn] Kaohsiung J Med Sci. 2004 Dec;20(12):612-5 [15696793.001]
  • (PMID = 15960073.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] China (Republic : 1949- )
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17. Park BK: Re: Adrenal pheochromocytoma: correlation of MRI appearances with histology and function. Eur Radiol; 2009 Sep;19(9):2310-1; author reply 2312-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Re: Adrenal pheochromocytoma: correlation of MRI appearances with histology and function.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Glands / pathology. Magnetic Resonance Imaging / methods. Pheochromocytoma / diagnosis


18. Azhough R, Barband AR, Motayagheni N, Niafar M, Pourfathi H: Spontaneous rupture of adrenal pheochromocytoma in a patient with Von Recklinghausen's disease. Indian J Crit Care Med; 2009 Apr-Jun;13(2):94-5

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  • [Title] Spontaneous rupture of adrenal pheochromocytoma in a patient with Von Recklinghausen's disease.
  • Spontaneous rupture of an adrenal pheochromocytoma is extremely rare and can be lethal because of dramatic changes in the circulation.
  • We describe a 35-year-old Iranian female with previously diagnosed von Recklinghausen ' s disease who suffered spontaneous rupture of an adrenal pheochromocytoma, misdiagnosed as renal colic followed by an extensive retroperitoneal hematoma, irreversible hemodynamic shock, and death.

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  • [ISSN] 1998-359X
  • [Journal-full-title] Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
  • [ISO-abbreviation] Indian J Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
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19. González JI, Angoso M, García JA, Clemen JJ, Prado A, Angoso F: [Extra-adrenal pheochromocytoma: update of the most controversial features. Apropos of two cases]. Cir Esp; 2005 Mar;77(3):166-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extra-adrenal pheochromocytoma: update of the most controversial features. Apropos of two cases].
  • [Transliterated title] Feocromocitoma extraadrenal: actualización de los aspectos más controvertidos. A propósito de dos casos.
  • Pheochromocytomas are uncommon neuroendocrine tumors.
  • They are usually symptomatic and sporadic and are generally located in the adrenal medulla.
  • We present two cases of extra-adrenal nonfunctional pheochromocytomas located in the retroperitoneum.
  • Several immunohistochemical techniques were performed to reach the definitive diagnosis.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radiography. Pheochromocytoma / pathology. Pheochromocytoma / radiography

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  • (PMID = 16420910.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 16
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20. Disick GI, Palese MA: Extra-adrenal pheochromocytoma: diagnosis and management. Curr Urol Rep; 2007 Jan;8(1):83-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal pheochromocytoma: diagnosis and management.
  • Extra-adrenal pheochromocytomas (EAPs) may arise in any portion of the paraganglion system, though they most commonly occur below the diaphragm, frequently in the organ of Zuckerkandl.
  • EAPs probably represent at least 15% of adult and 30% of childhood pheochromocytomas, as opposed to the traditional teaching that 10% of all pheochromocytomas are at extra-adrenal sites.
  • The diagnosis is confirmed by demonstrating elevated blood and urine levels of catecholamines and their metabolites.
  • EAPs recur and metastasize more often than their adrenal counterparts, making lifelong follow-up essential.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Pheochromocytoma / diagnosis. Pheochromocytoma / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Humans. Laparoscopy / methods. Magnetic Resonance Imaging. Male. Neoplasm Staging. Risk Assessment. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17239321.001).
  • [ISSN] 1534-6285
  • [Journal-full-title] Current urology reports
  • [ISO-abbreviation] Curr Urol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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21. Kheir E, Pal D, Mohanlal P, Shivane A, Chakrabarty A, Timothy J: Cervical spine metastasis from adrenal pheochromocytoma. Acta Neurochir (Wien); 2006 Nov;148(11):1219-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical spine metastasis from adrenal pheochromocytoma.
  • We report a rare presentation of metastatic pheochromocytoma of the cervical spine which was successfully treated operatively.
  • Adequate precautions should be taken during surgery as the tumour is very vascular.
  • Radiotherapy is useful in the treatment of residual tumour.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Cervical Vertebrae / pathology. Pheochromocytoma / secondary. Spinal Neoplasms / secondary
  • [MeSH-minor] Aged. Blood Loss, Surgical / prevention & control. Decompression, Surgical. Humans. Internal Fixators. Intraoperative Complications / etiology. Magnetic Resonance Imaging. Male. Neoplasm, Residual. Neurosurgical Procedures. Paresis / etiology. Paresthesia / etiology. Spinal Cord Compression / etiology. Spinal Fusion. Treatment Outcome


22. Kamal AH, Swetz KM, Liu H, Ruegg SR, Carey EC, Whitford K, Bock FA, Creagan ET, Moynihan TJ, Kaur JS: Survival trends in palliative care patients with cancer: A Mayo Clinic 5-year review. J Clin Oncol; 2009 May 20;27(15_suppl):9592

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival trends in palliative care patients with cancer: A Mayo Clinic 5-year review.
  • : 9592 Background: Palliative care (PC) is an essential part of the continuum of care for cancer (CA) patients (pts).
  • Little is known about the aggregate characteristics and survival of pts receiving inpatient palliative care consultation (PCC).
  • METHODS: We reviewed data prospectively collected on patients seen by the Palliative Care Inpatient Consult Service at Mayo Clinic - Rochester from 2003-2008.
  • Cancer is the most common primary diagnosis (47%).
  • Growth in annual PCC has risen dramatically (113 in 2003 vs. 414 in 2007) despite stable total hospital admissions.
  • General medicine, medical cardiology, and medical intensive care unit services refer most often.
  • Most frequent issues addressed are goals of care, dismissal planning, and pain control (29%, 19%, 17%).
  • PCC in actively dying pts have increased with 27% of all non-operating room, non-trauma in-hospital deaths being seen.
  • Although CA pts have the highest median survival after PCC vs. other diagnoses (17 days, p = 0.018), we observed a five-year trend of decreasing survival from admission to death and PCC to death.
  • Median time from PCC to death is 33 versus 11.5 days (p<0.01).
  • Despite this, median hospital length of stay and time from PCC to discharge have remained fixed at 8 and 2.5 days, respectively.
  • With the trend of shorter survival after PCC, PC professionals have little over two days to implement a comprehensive, ongoing care plan.
  • This highlights the importance of earlier outpatient palliative care involvement with advanced cancer patients and families.

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  • (PMID = 27963727.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Robledo AB, Ponce Marco JL, Ibáñez TB, Meseguer Anastasio MF, Gómez-Gavara C: Pheochromocytomatosis: A Risk after Pheochromocytoma Surgery. Am Surg; 2010 Aug 01;76(8):122-124

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pheochromocytomatosis: A Risk after Pheochromocytoma Surgery.

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  • (PMID = 28958230.001).
  • [ISSN] 1555-9823
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Pinna G, Ghiani M, Mariotti S: Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene. Clin Endocrinol (Oxf); 2008 May;68(5):836
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics. Proto-Oncogene Proteins c-ret / genetics

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  • [CommentOn] Clin Endocrinol (Oxf). 2007 Jul;67(1):29-33 [17466010.001]
  • (PMID = 17970769.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human
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25. Liao CH, Chueh SC: Laparoscopic adrenalectomy for a 6-cm left adrenal pheochromocytoma with needlescopic instruments. J Endourol; 2008 Sep;22(9):1949-51; discussion 1953
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic adrenalectomy for a 6-cm left adrenal pheochromocytoma with needlescopic instruments.

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  • (PMID = 18811502.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Fiebrich H, Brouwers AH, Kerstens MN, Pijl ME, Kema IP, de Jong JR, van der Wal JE, Sluiter WJ, de Vries EG, Links TP: Sensitivity of 6-[F-18]fluoro-L-dihydroxyphenylalanine positron emission tomography for localizing tumors causing catecholamine excess. J Clin Oncol; 2009 May 20;27(15_suppl):11064

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sensitivity of 6-[F-18]fluoro-L-dihydroxyphenylalanine positron emission tomography for localizing tumors causing catecholamine excess.
  • : 11064 Background: Positron emission tomography (PET) using the catecholamine precursor 6-[F-18]fluoro-L-dihydroxyphenylalanine (<sup>18</sup>F-DOPA) has emerged as promising technique to localize tumors with catecholamine excess.
  • This study investigated the sensitivity of <sup>18</sup>F-DOPA PET, compared to <sup>123</sup>I-metaiodobenzylguanidine (<sup>123</sup>I-MIBG) scintigraphy and computer tomography (CT)/ magnetic resonance imaging (MRI) in patients with catecholamine excess.
  • METHODS: In a single center prospective study <sup>18</sup>F-DOPA PET was compared to <sup>123</sup>I-MIBG and CT/MRI in patients with catecholamine excess.
  • The tumor localization was found in 45 patients, 43 with <sup>18</sup>F-DOPA PET, 31 with <sup>123</sup>I-MIBG and 32 with CT/MRI, resulting with surgery in final diagnosis of pheochromocytoma in 40, adrenal hyperplasia in 2, paraganglioma in 2, ganglioneuroma in 1 and 3 unknown (as yet no lesion detected).
  • The <sup>8</sup>F-DOPA PET+CT/MRI combination was superior to <sup>123</sup>I-MIBG+CT/MRI (93 vs 76%, P<.001) Whole body metabolic burden measured with <sup>18</sup>F-DOPA PET correlated with plasma free normetanephrine (r=.82) and 24h urinary total normetanephrine (r=.84) and metanephrine (r=.57).
  • CONCLUSIONS: The sensitivity of <sup>18</sup>F-DOPA PET to localize tumors with catecholamine excess is superior to either <sup>123</sup>I-MIBG scintigraphy or CT/MRI.

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  • (PMID = 27963142.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Song G, Zhou LQ, Cai L: [Safety analysis of laparoscopic adrenalectomy for adrenal pheochromocytoma of 5 to 10 cm]. Zhonghua Wai Ke Za Zhi; 2008 Aug 15;46(16):1245-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Safety analysis of laparoscopic adrenalectomy for adrenal pheochromocytoma of 5 to 10 cm].
  • OBJECTIVE: To investigate the safety of laparoscopic adrenalectomy for adrenal pheochromocytoma with maximum diameter of 5 - 10 cm.
  • METHODS: Retrospective analysis was performed for 79 consecutive patients who underwent adrenalectomy for adrenal pheochromocytoma between January 2001 and June 2007.
  • RESULTS: There was no significant difference in age, maximum diameter of tumor, the highest preoperative systolic/diastolic pressure, the preoperative heart rate and the plasma catecholamines between the two groups (P > 0.05).
  • CONCLUSIONS: For adrenal pheochromocytoma with maximum diameter of 5 - 10 cm, the laparoscopic procedure decreased operative time, blood loss, blood-transfusion and postoperative hospital stay compared to traditional open surgery.
  • Adrenal pheochromocytoma of 5 - 10 cm is not a contraindication of laparoscopic surgery and experienced urologists can perform it safely for large adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Laparoscopy. Pheochromocytoma / surgery

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  • (PMID = 19094601.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Castillo OA, Vitagliano G, Olivares R, Soffia P, Contreras M: Laparoscopic resection of an extra-adrenal pheochromocytoma. Surg Laparosc Endosc Percutan Tech; 2007 Aug;17(4):351-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic resection of an extra-adrenal pheochromocytoma.
  • Extra-adrenal pheochromocytomas are of rare occurrence.
  • Since first reported laparoscopic adrenalectomy has become the gold standard in the treatment of adrenal tumors, the feasibility of laparoscopic adrenalectomy in the setting of pheochromocytoma has also been established given a careful preoperative planning.
  • Literature on the laparoscopic treatment of extra-adrenal pheochromocytomas is lacking.
  • The patient underwent complete transperitoneal laparoscopic excision of the tumor.
  • Recovery was uneventful and final histopathologic examination showed an extra-adrenal pheochromocytoma.
  • We believe that transperitoneal laparoscopic excision of extra-adrenal pheochromocytoma is a feasible and reproducible technique that allows for complete removal of tumoral tissue with low morbidity, shorter hospital stay, and minimal convalescence.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Pheochromocytoma / surgery

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  • (PMID = 17710068.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Kuramoto T, Nishizawa S, Fujii R, Nanpou Y, Matsumura N, Inagaki T, Kohjimoto Y, Hara I: [Extra-adrenal pheochromocytoma with the manifestation of catecholamines cardiomyopathy: a case report]. Hinyokika Kiyo; 2010 Nov;56(11):625-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extra-adrenal pheochromocytoma with the manifestation of catecholamines cardiomyopathy: a case report].
  • Since computed tomography (CT) with coronary angiography to rule out acute coronary syndrome showed no abnormalities, she was diagnosed with morphological stress cardiomyopathy due to akinesis of the apical area.
  • From these results, a diagnosis of extra-adrenal pheochromocytoma with catecholamine-induced cardiomyopathy was made.
  • Histological diagnosis of the laparoscopically resected tumor was pheochromocytoma.
  • [MeSH-major] Cardiomyopathies / etiology. Catecholamines / secretion. Pheochromocytoma / complications. Retroperitoneal Neoplasms / complications

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  • (PMID = 21187707.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Catecholamines
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30. Seimiya YM, Takahashi M, Furukawa T, Mizutani K, Kimura K, Haritani M: An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma. J Vet Med Sci; 2009 Feb;71(2):225-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma.
  • Pathological examination disclosed multiple endocrine tumors including thyroid C cell carcinoma with metastases to the cervical lymph nodes and lung, adrenal pheochromocytoma and pituitary chromophobe adenoma in the pars distalis.


31. Wallis L: Anewline in men's talk. Nurs Stand; 2005 Jan 19;19(19):16-17

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • ' Ms Spickett is a urology nurse specialist who works for the Prostate Cancer Charity (PCC).
  • Based in London, she is one of a team of six nurses who staff the helpline.
  • She is talking to the wife of a man in the final stages of terminal prostate cancer.

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  • (PMID = 28006525.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Yamaga LY, Thom AF, Wagner J, Baroni RH, Hidal JT, Funari MG: The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by (18)F-FDG PET/CT in a patient with adrenal pheochromocytoma. Eur J Nucl Med Mol Imaging; 2008 Feb;35(2):446-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by (18)F-FDG PET/CT in a patient with adrenal pheochromocytoma.
  • [MeSH-major] Adipose Tissue, Brown / diagnostic imaging. Adipose Tissue, Brown / metabolism. Adrenal Gland Neoplasms / diagnostic imaging. Adrenal Gland Neoplasms / metabolism. Catecholamines / administration & dosage. Fluorodeoxyglucose F18 / pharmacokinetics. Pheochromocytoma / diagnostic imaging. Pheochromocytoma / metabolism
  • [MeSH-minor] Diagnosis, Differential. Glucose / pharmacokinetics. Humans. Male. Middle Aged. Positron-Emission Tomography / methods. Radiopharmaceuticals / pharmacokinetics. Tomography, X-Ray Computed / methods

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  • [Cites] Eur J Nucl Med Mol Imaging. 2002 Oct;29(10 ):1393-8 [12271425.001]
  • [Cites] FEBS Lett. 1985 Sep 2;188(2):257-61 [3896847.001]
  • [Cites] J Biochem. 1991 Nov;110(5):688-92 [1783598.001]
  • [Cites] Anat Rec. 1986 Jul;215(3):251-5, 227-9 [3740464.001]
  • [Cites] Hum Pathol. 1985 Jun;16(6):580-9 [3997135.001]
  • (PMID = 17909796.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; IY9XDZ35W2 / Glucose
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33. Okutur K, Küçükler K, Öztekın E, Borlu F, Erdem L, Demır G: A rare cause of acute abdomen: ruptured adrenal pheochromocytoma. Turk J Gastroenterol; 2010 Dec;21(4):467-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare cause of acute abdomen: ruptured adrenal pheochromocytoma.
  • Pheochromocytoma is a tumor of the chromaffin cells which secretes catecholamines and 90% of it originates from adrenal medulla.
  • Here we present a 43 year old male patient who applied with acute abdominal syndrome and severe hypertension.
  • At laparotomy, ruptured adrenal mass was seen and excised successfully.
  • The histological evaluation confirmed the diagnosis as pheochromocytoma.
  • Ruptured adrenal pheochromocytoma is a mortal situation potentially and it should be considered in patients who present with an acute abdominal syndrome and hypertension or shock.
  • It should be known that early diagnosis and surgery with proper preoperative treatment is a life saver.
  • [MeSH-major] Abdomen, Acute / etiology. Adrenal Gland Neoplasms / complications. Hypertension / etiology. Pheochromocytoma / complications

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  • (PMID = 21332008.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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34. Fujii M, Kawabata Y, Hayashi T, Nishimae H, Masuko S, Nosaka S: [Anesthetic management for laparoscopic resection of adrenal pheochromocytoma in a woman with chronic renal failure]. Masui; 2010 Mar;59(3):393-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anesthetic management for laparoscopic resection of adrenal pheochromocytoma in a woman with chronic renal failure].
  • A 52-year-old woman, undergoing hemodialysis for chronic renal failure over thirty years, developed pheochromocytoma.
  • Her serum concentrations of noradrenaline (NA) and adrenaline were 5,330 pg x ml(-1) and 212 pg x ml(-1), respectively.
  • Although hypotension occurred temporarily after CHDF, severe hemodynamic changes were not observed during operation owing to NA substitution and infusion of 5% plasma protein fraction, and the operation was finished uneventfully.
  • CHDF was useful for anesthetic management of a patient with adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Anesthesia, General. Kidney Failure, Chronic / complications. Laparoscopy. Perioperative Care. Pheochromocytoma / surgery

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  • (PMID = 20229764.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antihypertensive Agents
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35. Extermann M: Geriatric oncology: The ultimate personalized cancer care. J Clin Oncol; 2009 May 20;27(15_suppl):s2a

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Geriatric oncology: The ultimate personalized cancer care.
  • : s2a In many aspects, geriatric oncology is the quintessential expression of ASCO's 2009 theme: personalizing cancer care (PCC).
  • PCC has two aspects: the tumor and the patient.
  • Major efforts are conducted to identify mechanisms in an individual tumor that could be targeted more effectively by therapies.
  • As the world population ages, we are progressing toward providing cancer care tailored to both the tumor and the older cancer patient.

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  • (PMID = 27961889.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Miller C, Bernet V, Elkas JC, Dainty L, Gherman RB: Conservative management of extra-adrenal pheochromocytoma during pregnancy. Obstet Gynecol; 2005 May;105(5 Pt 2):1185-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of extra-adrenal pheochromocytoma during pregnancy.
  • BACKGROUND: Extra-adrenal pheochromocytomas are catecholamine-secreting tumors that arise from chromaffin cells of the paraganglion sympathetic system.
  • CASE: At 14 weeks of gestation, a multiparous patient was diagnosed with an extra-adrenal dopaminergic pheochromocytoma.
  • Three weeks later, the extra-adrenal pheochromocytoma was removed, and she also underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and rectosigmoid resection with end-to-end colostomy.
  • CONCLUSION: Conservative management of dopaminergic-secreting extra-adrenal pheochromocytomas can result in favorable maternal and fetal outcomes.
  • [MeSH-major] Adrenal Gland Neoplasms / drug therapy. Phenoxybenzamine / therapeutic use. Pheochromocytoma / drug therapy. Pregnancy Complications, Neoplastic / drug therapy. Pregnancy Outcome


37. Sesay M, Tauzin-Fin P, Gosse P, Ballanger P, Maurette P: Real-time heart rate variability and its correlation with plasma catecholamines during laparoscopic adrenal pheochromocytoma surgery. Anesth Analg; 2008 Jan;106(1):164-70, table of contents
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Real-time heart rate variability and its correlation with plasma catecholamines during laparoscopic adrenal pheochromocytoma surgery.
  • BACKGROUND: We studied sympathovagal activity using real-time heart rate variability (HRV) and determined its relationship with plasma catecholamines to characterize short-term cardioregulatory mechanisms during laparoscopic adrenal pheochromocytoma surgery.
  • METHODS: We recruited 20 patients with pheochromocytoma (Group P) and 20 with incidentaloma (Group I).
  • In Group P, epinephrine and norepinephrine increased in all patients during peritoneal insufflation and tumor resection.
  • CONCLUSION: This study demonstrated a strong correlation between low frequency HRV, plasma norepinephrine, arterial blood pressure, and heart rate during pheochromocytoma surgery.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy. Cardiovascular System / innervation. Catecholamines / blood. Heart Rate. Pheochromocytoma / surgery. Sympathetic Nervous System / physiopathology. Vagus Nerve / physiopathology

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  • (PMID = 18165573.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catecholamines; X4W3ENH1CV / Norepinephrine; YKH834O4BH / Epinephrine
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38. Jin CM, Yang YJ, Huang HS, Kai M, Lee MK: Mechanisms of L-DOPA-induced cytotoxicity in rat adrenal pheochromocytoma cells: implication of oxidative stress-related kinases and cyclic AMP. Neuroscience; 2010 Oct 13;170(2):390-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mechanisms of L-DOPA-induced cytotoxicity in rat adrenal pheochromocytoma cells: implication of oxidative stress-related kinases and cyclic AMP.
  • L-DOPA therapy for Parkinson's disease has a double-edge effect on nigrostriatal dopaminergic neurons: L-DOPA increases the intracellular level of dopamine, but it induces neuron cytotoxicity in a concentration-dependent manner.
  • To investigate the molecular signaling mechanisms that underlie the concentration-dependent effects of L-DOPA on cell viability, the activities of mitogen-activated protein kinases (MAPKs) and apoptotic enzymes were measured in rat adrenal pheochromocytoma (PC12) cells in the presence of a low concentration (20 muM) and high concentrations (100-200 muM) of L-DOPA.
  • At the low concentration, L-DOPA was not cytotoxic and its presence increased the activities of extracellular signal-regulated kinase (ERK)1/2, p38 MAPK, BadSer112, Bcl-2, and caspase-12.
  • At the high concentrations, L-DOPA was cytotoxic and stimulated the activities of ERK1/2, p38 MAPK, c-Jun N-terminal kinase (JNK)1/2, BadSer155, caspase-12 and caspase-3.
  • The increased levels of ERK1/2 and BadSer155 in the presence of high concentrations of L-DOPA did not protect against L-DOPA-mediated cytotoxicity.
  • In addition, the levels of L-type Ca(2+) channel-sensitive intracellular cyclic AMP (cAMP) and Ca(2+) were elevated in the presence of L-DOPA, and the increase in the levels of intracellular cAMP may also play a role in cellular viability, since cAMP levels and cytotoxicity increased in parallel with L-DOPA concentrations and the addition of forskolin in the medium increased cytotoxicity in a concentration-dependent manner.
  • These results suggest that, at a low and non-toxic concentration, L-DOPA may promote cell survival by increasing the activities of ERK1/2, BadSer112 and Bcl-2, while, at high concentrations, L-DOPA activates the caspase-3 cell death enzyme through the JNK1/2 and p38 MAPK signaling pathways as well as endoplasmic reticulum stress that activates caspase-12.
  • The results may lead to an effective therapy for Parkinson's disease.

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  • [Copyright] Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20670675.001).
  • [ISSN] 1873-7544
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1F7A44V6OU / Colforsin; 46627O600J / Levodopa; E0399OZS9N / Cyclic AMP; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; SY7Q814VUP / Calcium
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39. Guzik P, Wykretowicz A, Wesseling IK, Wysocki H: Adrenal pheochromocytoma associated with dramatic cyclic hemodynamic fluctuations. Int J Cardiol; 2005 Sep 1;103(3):351-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal pheochromocytoma associated with dramatic cyclic hemodynamic fluctuations.
  • A 52-year-old woman with a right adrenal pheochromocytoma had repetitive attacks of symptomatic hypotension/shock with systolic blood pressure (SBP)<50 mmHg followed by hypertension/hypertensive crises with SBP>300 mmHg.
  • [MeSH-major] Adrenal Gland Neoplasms / physiopathology. Pheochromocytoma / physiopathology

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  • (PMID = 16098406.001).
  • [ISSN] 0167-5273
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
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40. Machens A, Brauckhoff M, Gimm O, Dralle H: Risk-oriented approach to hereditary adrenal pheochromocytoma. Ann N Y Acad Sci; 2006 Aug;1073:417-28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk-oriented approach to hereditary adrenal pheochromocytoma.
  • Hereditary adrenal pheochromocytoma is caused by germline mutations in RET, VHL, SDHB, SDHD, and NF1.
  • As these genes differ in function, so may their pheochromocytoma phenotypes, suggesting gene-specific patterns of age-related progression to pheochromocytoma.
  • This possibility was explored for gene carriers with a lifetime risk of pheochromocytoma in excess of 50%.
  • Published age-standardized penetrance rates of VHL-, SDHB-, and SDHD-associated pheochromocytoma were gauged against age-standardized penetrance rates of MEN2-associated pheochromocytoma in 219 institutional carriers of RET mutations conferring highest (codon 918), high (codons 609, 611, 618, 620, 630, and 634) and least high risk (codons 768, 790, 791, 804, and 891).
  • Ipsilateral recurrences in adrenal remnants, and contralateral recurrences in virgin adrenals were comparable in incidence (27% and 39%, P=0.69; high-risk RET category) and time to recurrence (means of 4.3 vs. 5.4 year; P>0.99; high-risk RET category), discounting a major effect of tumor spillage at primary subtotal adrenalectomy on pheochromocytoma recurrence.
  • For most hereditary pheochromocytomas, endoscopic subtotal adrenalectomy is the procedure of choice.
  • Grouping hereditary pheochromocytoma into preliminary risk categories may improve the management of gene carriers at risk of developing pheochromocytomas.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Genes, Neurofibromatosis 1. Germ-Line Mutation. Humans. Proto-Oncogene Proteins c-ret / genetics. Recurrence. Risk. Succinate Dehydrogenase / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 17102110.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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41. Sunagawa H, Inamine S, Zaha H, Takeshima M, Miyata M: Advanced gastric carcinoma combined with extra-adrenal pheochromocytoma resected after three courses of S-1 and cisplatin as neoadjuvant chemotherapy: report of a case. Surg Today; 2008;38(5):445-8
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  • [Title] Advanced gastric carcinoma combined with extra-adrenal pheochromocytoma resected after three courses of S-1 and cisplatin as neoadjuvant chemotherapy: report of a case.
  • We herein describe the case of a patient with advanced gastric carcinoma combined with extra-adrenal pheochromocytoma who received a radical operation after undergoing neoadjuvant chemotherapy.
  • A diagnosis of advanced gastric carcinoma was made (cT3, cN3, cM0, cStage IV according to the Japanese Classification of Gastric Carcinoma, 2nd English edition).
  • A reduction in size was observed in both the gastric tumor and the lymph nodes around the stomach after neoadjuvant chemotherapy.
  • We thus suspected this para-aortic tumor not to be a lymph node, but instead to be an extra-adrenal pheochromocytoma, because of the different response from the other regional lymph nodes.
  • An endocrinological examination confirmed the diagnosis of extra-adrenal pheochromocytoma.
  • A gastrectomy and a resection of the pheochromocytoma were thus performed.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Pheochromocytoma / surgery. Stomach Neoplasms / therapy

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  • [Cites] J Clin Gastroenterol. 2002 May-Jun;34(5):533-5 [11960064.001]
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  • (PMID = 18560969.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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42. Lai EW, Rodriguez OC, Aventian M, Cromelin C, Fricke ST, Martiniova L, Lubensky IA, Lisanti MP, Picard KL, Powers JF, Tischler AS, Pacak K, Albanese C: ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice. Cell Cycle; 2007 Aug 01;6(15):1946-50
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  • [Title] ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice.
  • Pheochromocytoma (PCC) is a rare catecholamine-producing tumor that arises from the adrenal medulla and is often familial.
  • The genetic basis for familial PCC involves mutations of RET, VHL, SHDx or NF-1 in more than 20% of cases.
  • Additional genes may be important in pathogenesis of both familial and sporadic PCC.
  • ErbB-2/Her2/Neu is a growth factor receptor tyrosine kinase that is frequently overexpressed in tumors and there is clinical evidence suggesting that enhanced ErbB-2 growth factor receptor signaling may play a role in PCC.
  • In the present study, ectopic expression of an activated ErbB-2 transgene resulted in bilateral adrenal PCC.
  • Analyses of tumor samples and normal adrenal tissue revealed that levels of the Pten tumor suppressor protein were greatly reduced in PCCs, while levels of the cell cycle regulatory protein cyclin D1 were usually increased.
  • In addition, levels of phospo-AKT were increased in PCCs versus normal adrenal tissue.
  • Biochemical analyses established that PCC's were functionally active, producing abundant levels of the catecholamines, epinephrine and norepinephrine.
  • These data establish that increased ErbB-2 growth factor receptor signaling in the adrenal medulla can lead to PCC through combined influences on Pten, AKT andcyclin D1.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Adrenal Gland Neoplasms / pathology. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. Pheochromocytoma / metabolism. Pheochromocytoma / pathology. Receptor, ErbB-2 / metabolism


43. Ikuta S, Yasui C, Kawanaka M, Aihara T, Yoshie H, Yanagi H, Mitsunobu M, Sugihara A, Yamanaka N: Watery diarrhea, hypokalemia and achlorhydria syndrome due to an adrenal pheochromocytoma. World J Gastroenterol; 2007 Sep 14;13(34):4649-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Watery diarrhea, hypokalemia and achlorhydria syndrome due to an adrenal pheochromocytoma.
  • Watery diarrhea, hypokalemia and achlorhydria (WDHA) syndrome caused by vasoactive intestinal polypeptide (VIP) -producing tumor only rarely occurs in patients with nonpancreatic disease.
  • A 49-year-old woman was referred for evaluation of a right adrenal tumor incidentally diagnosed by abdominal ultrasound during the investigation of chronic watery diarrhea.
  • After surgical resection of the tumor, diarrhea subsided and both electrolytes and affected hormone levels normalized.
  • Immunohistochemical examination confirmed a diagnosis of pheochromocytoma, which contained VIP-positive ganglion-like cells.
  • [MeSH-major] Achlorhydria / etiology. Adrenal Gland Neoplasms / diagnosis. Diarrhea / etiology. Hypokalemia / etiology. Incidental Findings. Pheochromocytoma / diagnosis. Vipoma / diagnosis


44. Ozbay A, Obukhau A, Buhl L, Brøndt Hartlev L, Løgstrup Poulsen P: Adrenal pheochromocytoma producing vasoactive intestinal peptide and masking hypertension. Horm Res; 2008;70(3):188-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal pheochromocytoma producing vasoactive intestinal peptide and masking hypertension.
  • AIM: To report a case of a pheochromocytoma secreting vasoactive intestinal peptide (VIP).
  • Initially gastrointestinal investigations were carried out based on longstanding diarrhea with hypopotassemia, but radiological imaging revealed a unilateral adrenal mass.
  • Biochemical testing showed increased levels of catecholamine and VIP, and (123)I-metaiodobenzylguanidine scintigraphy confirmed the adrenal origin as well as the diagnosis of a VIP-producing pheochromocytoma.
  • The patient underwent surgical removal of the tumor which led to relief of symptoms and normalized laboratory values.
  • CONCLUSION: This case report focuses on the protean mode of presentation seen in pheochromocytomas as well as their capacity to produce several neuropeptides, ultimately intensifying the need for early examination for this condition despite unrelated symptoms.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Hypertension / diagnosis. Pheochromocytoma / metabolism. Vasoactive Intestinal Peptide / biosynthesis


45. Pua U, Wong DE: Transarterial embolisation of spontaneous adrenal pheochromocytoma rupture using polyvinyl alcohol particles. Singapore Med J; 2008 May;49(5):e126-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transarterial embolisation of spontaneous adrenal pheochromocytoma rupture using polyvinyl alcohol particles.
  • The spontaneous rupture of a phaeochromocytoma is a rare and potentially fatal complication.
  • Prompt diagnosis, patient stabilisation and adrenectomy are crucial for survival.
  • We describe transcatheter arterial embolisation (TAE) using polyvinyl alcohol particles (PVA) in restoring haemodynamic stability during an acute phaeochromocytoma rupture in a 67-year-old man to avoid the risks of performing an emergency adrenectomy.
  • To the best of our knowledge, TAE using PVA in an acute phaeochromocytoma rupture has not been previously reported in the English literature.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Embolization, Therapeutic / methods. Pheochromocytoma / therapy. Polyvinyl Alcohol
  • [MeSH-minor] Adrenal Glands / blood supply. Aged. Hemorrhage / etiology. Hemorrhage / therapy. Humans. Male. Rupture, Spontaneous

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  • (PMID = 18465036.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 9002-89-5 / Polyvinyl Alcohol
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46. Korpershoek E, Petri BJ, van Nederveen FH, Dinjens WN, Verhofstad AA, de Herder WW, Schmid S, Perren A, Komminoth P, de Krijger RR: Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma. Endocr Relat Cancer; 2007 Jun;14(2):453-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.
  • Pheochromocytomas (PCCs) are rare tumors that arise from chromaffin tissue in the adrenal medulla, but can also occur in the abdomen outside the adrenals and are then called sympathetic paragangliomas (sPGLs).
  • According to the literature, between 15 and 25% of apparently sporadic adrenal PCC and sPGL are caused by germline mutations in RET, von Hippel-Lindau disease (VHL), succinate dehydrogenase subunit B (SDHB), or subunit D SDHD.
  • However, few studies have addressed the mutationfrequency of these candidate genes in selected subgroups of PCC andsPGL, such as bilateral adrenal PCC or extra-adrenal sPGL, and none have looked at somatic mutations by analyzing tumor tissue.
  • Therefore, we have investigated the occurrence of germline and somatic mutations in RET, VHL, SDHB, and SDHD in comparatively large series of bilateral adrenal PCC (n = 33 patients) and sPGL (n = 26 patients), with the aim of determining the mutation frequency of each of these genes and to establish a genetic testing algorithm.
  • Twenty-one RET, two VHL germline, and one SDHD mutations were found in the patients with bilateral adrenal PCC.
  • We conclude that germline RET mutations are predominantly found in bilateral PCC, and that somatic and germline SDHB and SDHD mutations usually occur in sPGL, which has practical consequences for genetic testing algorithms.
  • We suggest that sequential mutation analysis should be directed first at RET, followed by VHL and SDHD for patients with bilateral adrenal PCC at diagnosis, and at SDHB and SDHD for patients with sPGL.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genes, Neoplasm. Paraganglioma / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Adult. Aged. Amino Acid Sequence. Animals. Cattle. DNA Mutational Analysis. Female. Germ-Line Mutation. Humans. Iron-Sulfur Proteins / genetics. Male. Mice. Middle Aged. Molecular Sequence Data. Mutation. Proto-Oncogene Proteins c-ret / genetics. Rats. Succinate Dehydrogenase / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 17639058.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins; 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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47. Donahue J, Sahani D, Tso L, Cusack JC Jr: Extra-adrenal pheochromocytoma involving the organ of Zuckerkandl. Surgery; 2008 Jun;143(6):830-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal pheochromocytoma involving the organ of Zuckerkandl.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Para-Aortic Bodies / pathology. Pheochromocytoma / diagnosis

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  • (PMID = 18549902.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SDHD protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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48. Malindretos PM, Sarafidis PA, Geropoulou EZ, Kapoulas S, Paramythiotis DD, Lasaridis AN: Sustained hypotension complicating an extra-adrenal pheochromocytoma. Am J Hypertens; 2008 Jul;21(7):840-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sustained hypotension complicating an extra-adrenal pheochromocytoma.
  • [MeSH-major] Hypertension / etiology. Hypotension / etiology. Pheochromocytoma / complications. Retroperitoneal Neoplasms / complications

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  • (PMID = 18464747.001).
  • [ISSN] 0895-7061
  • [Journal-full-title] American journal of hypertension
  • [ISO-abbreviation] Am. J. Hypertens.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Vasoconstrictor Agents
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49. Cheng CI, Wang HJ, Huang CC, Chen CJ, Yang CH, Fang CY, Hsieh YK, Yeh KH, Yip HK, Chen MC, Wu CJ, Fu M: Adrenal pheochromocytoma associated with transient hyperreninemia. Int J Cardiol; 2006 Jul 28;111(1):180-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal pheochromocytoma associated with transient hyperreninemia.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Pheochromocytoma / complications. Renin / blood

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  • (PMID = 16427710.001).
  • [ISSN] 0167-5273
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 3.4.23.15 / Renin
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50. Kobayashi T, Iwai A, Takahashi R, Ide Y, Nishizawa K, Mitsumori K: Spontaneous rupture of adrenal pheochromocytoma: review and analysis of prognostic factors. J Surg Oncol; 2005 Apr 1;90(1):31-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous rupture of adrenal pheochromocytoma: review and analysis of prognostic factors.
  • BACKGROUND AND OBJECTIVES: Because of its rarity, the clinical characteristics of the manifestation of a ruptured pheochromocytoma and factors influencing on treatment outcomes in patients are still unclear.
  • METHODS: A comprehensive MEDLINE review of the literature on pheochromocytomas, rupture and hemorrhage was performed.
  • Based on the review and one additional case of our hospital, statistical analysis was undertaken to analyze the association of clinical outcome with clinical presentation, preoperative diagnosis, and treatment modality.
  • RESULTS: We identified 49 other cases of hemorrhagic pheochromocytoma in the literature.
  • An accurate preoperative diagnosis of pheochromocytoma was associated with elective surgery (P < 0.0001), and hemodynamic instability (shock status) was a significant factor for a failed diagnosis and inadequate management, resulting in a poor prognosis (P = 0.023).
  • CONCLUSIONS: Although it is a very rare condition, physicians should be aware that a pheochromocytoma can bleed and present acutely in the abdomen with shock; an accurate diagnosis and adequately prepared surgical removal are important for a good postoperative prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / surgery. Pheochromocytoma / complications. Pheochromocytoma / surgery

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15786413.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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51. Moretti A, Minuto M, Berti P, Bernini GP, Mannelli M, Miccoli P: Unusual association of adrenal pheochromocytoma and para-aortic neurofibroma in pregnancy. J Endocrinol Invest; 2006 Sep;29(8):738-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual association of adrenal pheochromocytoma and para-aortic neurofibroma in pregnancy.
  • The association of pheochromocytoma (PHEO) and pregnancy is uncommon and life threatening for both the fetus and the mother.
  • Early diagnosis and treatment is essential to decrease maternal and fetal mortality and to differentiate the disease from the more common pre-eclampsia.
  • While medical treatment should be started immediately after diagnosis, the timing of surgical treatment is still debated.
  • We describe the case of a 27-yr-old woman in the 18th week of pregnancy who showed a biochemical pattern typical of PHEO and, by imaging studies, 2 tumors with the same characteristics: the first localized on the right adrenal gland, the second at the right renal hilum.
  • The patient underwent surgery because of suspicion of malignant PHEO with local metastasis, while histology revealed a rare association of a solitary PHEO and para-aortic neurofibroma, both tumors embryologically deriving from a common cell precursor.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Neurofibroma / complications. Para-Aortic Bodies / pathology. Pheochromocytoma / complications. Pregnancy Complications, Neoplastic / diagnosis


52. Sharma PK, Sharma P, Saraswat B: Extra adrenal pheochromocytoma of urinary bladder. Indian J Surg; 2008 Aug;70(4):188-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra adrenal pheochromocytoma of urinary bladder.
  • Pheochromocytoma of urinary bladder is rare disease causing a hypertension, palpitation, throbbing headache & hemorrhage induced by voiding.
  • This case is reported because of rarity of this disease in urinary bladder.

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  • [Cites] Urol Clin North Am. 1977 Jun;4(2):239-52 [19867.001]
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  • (PMID = 23133055.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452772
  • [Keywords] NOTNLM ; Bladder Tumors / Extra adrenal Pheochromocytoma / Pheochromocytoma of urinary bladder
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53. Montemurro S, Ruggieri E, Maselli E, Zito AF, Chiumarulo F, Gargano G: A rare case of extra-adrenal pheochromocytoma masquerading as an ovarian mass treated by laparoscopic surgery. Eur J Gynaecol Oncol; 2007;28(6):491-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of extra-adrenal pheochromocytoma masquerading as an ovarian mass treated by laparoscopic surgery.
  • BACKGROUND: Extra-adrenal pheochromocytoma, or paraganglioma, is a rare tumour arising from paraganglion chromaffin cells of the sympathetic nervous system.
  • In adults, pheochromocytomas are often called the "10% tumor" because approximately 10% occur above the diaphragm, 10% of intraabdominal pheochromocytomas are extra-adrenal, 10% are bilateral, 10% are multiple, 10% are familial, 10% are malignant, and 10% recur postoperatively.
  • In children, instead, this tumor occurs in ectopic sites in 30-40% of the cases.
  • This paper reports the successful laparoscopic resection of an extra-adrenal pheochromocytoma, simulating an ovarian tumor, combined with a laparoscopic cholecystectomy for gallstones.
  • CASE REPORT: The case of a 48-year-old woman affected by an extra-adrenal pheochromocytoma that had been unsuspected for a long time is presented.
  • The patient had some clinical symptoms that had been taken for a climacteric syndrome given her premenopausal age.
  • The atypical and rare location of the pheochromocytoma (parauterine) had contributed to misdiagnosing it as an ovarian tumor.
  • Laparoscopic surgery was chosen for the removal of the tumor because it is a safe technique requiring a shorter hospital stay; a concomitant cholecystectomy was performed due to the presence of gallstones.
  • CONCLUSION: Surgical resection is the only treatment option for extra-adrenal pheochromocytomas.
  • Gynecologists should consider the possibility, although rare, of an extra-adrenal pheocromocytoma when preparing to surgically remove a pelvic mass.
  • [MeSH-major] Laparoscopy. Ovarian Neoplasms / diagnosis. Pheochromocytoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Angiography. Middle Aged

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  • (PMID = 18179144.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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54. Ueshiba H: [Extra-adrenal pheochromocytoma (paraganglioma)]. Nihon Rinsho; 2006 May 28;Suppl 1:735-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extra-adrenal pheochromocytoma (paraganglioma)].
  • [MeSH-major] Paraganglioma, Extra-Adrenal

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  • (PMID = 16776262.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adrenergic alpha-Antagonists; 0 / Biomarkers; 0 / Catecholamines
  • [Number-of-references] 15
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55. Williams DS: Extra-adrenal pheochromocytoma. J Insur Med; 2007;39(3):214-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / diagnosis

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  • (PMID = 18251381.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. De Toma G, Letizia C, Cavallaro G, Polistena A, Cotesta D, Petramala L, Porciello R, Giustini S, Calvieri S: Adrenal pheochromocytoma and jejunal neurofibroma in type 1 neurofibromatosis: report of a case. G Chir; 2007 May;28(5):199-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal pheochromocytoma and jejunal neurofibroma in type 1 neurofibromatosis: report of a case.
  • INTRODUCTION: Neurofibromatosis type 1 (NF1), known as von Recklinghausen's disease, is characterized by presence of café au lait spots, and neurofibromas in the skin or along the course of peripheral nerves.
  • Diagnosis, despite extreme clinical variability, is defined by established diagnostic criteria.
  • CASE REPORT: A case of a patient affected by NF1, with hypertension due to adrenal pheochromocytoma and with jejunal neurofibroma, is reported.
  • DISCUSSION AND CONCLUSIONS: Variability in clinical presentation of NF1 with possible manifestation of severe systemic benign and malignant diseases requires strict follow-up and specific screening of extra-cutaneous lesions.
  • [MeSH-major] Adrenal Gland Neoplasms. Jejunal Neoplasms. Neoplasms, Multiple Primary. Neurofibromatosis 1. Pheochromocytoma


57. Dundamadappa SK, Shankar S, Danrad R, Singh A, Vijayaraghavan G, Kim Y, Perugini R: Imaging of brown fat associated with adrenal pheochromocytoma. Acta Radiol; 2007 May;48(4):468-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of brown fat associated with adrenal pheochromocytoma.
  • The association of adrenal pheochromocytoma and brown fat has been described in the pathology literature and scantily in the radiology literature.
  • We present a case of diffuse collection of brown fat in both perinephric spaces associated with left adrenal pheochromocytoma, and describe the computed tomography and magnetic resonance imaging findings.
  • [MeSH-major] Adipose Tissue, Brown / pathology. Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / diagnosis
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Image Enhancement. Magnetic Resonance Imaging. Radiographic Image Enhancement. Tomography, X-Ray Computed

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  • (PMID = 17453531.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media
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58. Padevit C, John H, Gunz A, Wiesli P, Hauri D, Schmid C: Micturition Syncope due to paraprostatic pheochromocytoma. Urol Int; 2005;74(3):276-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Micturition Syncope due to paraprostatic pheochromocytoma.
  • Paraprostatic pheochromocytoma is a very rare localization of extra-adrenal pheochromocytoma.
  • The clinical and anatomical features of a 41-year-old man are described.
  • [MeSH-major] Pheochromocytoma / complications. Prostatic Neoplasms / complications. Syncope / etiology
  • [MeSH-minor] Adult. Blood Pressure. Catecholamines / blood. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Urinary Bladder Neoplasms / pathology

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15812218.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Catecholamines
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59. Park JS, Lee KY, Kim JK, Yoon DS: The first laparoscopic resection of extra-adrenal pheochromocytoma using the da Vinci robotic system. J Laparoendosc Adv Surg Tech A; 2009 Feb;19(1):63-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The first laparoscopic resection of extra-adrenal pheochromocytoma using the da Vinci robotic system.
  • Laparoscopic surgery for pheochromocytoma is difficult because of the potential release of catecholamines, which may lead to severe intraoperative hemodynamic changes.
  • In particular, extra-adrenal pheochromocytoma imposes special demands on the laparoscopic surgical skills of the operator because of changes in anatomic disposition.
  • In this paper, we report a case of extra-adrenal pheochromocytoma, located in the vulnerable anatomic structures, taking place in tiny areas that were difficult to access and that was resected by using the da Vinci robotic system.
  • After our initial experience, we suggest the robot-assisted laparoscopic resection for extra-adrenal pheochromocytoma.
  • [MeSH-major] Abdominal Neoplasms / surgery. Laparoscopy / methods. Pheochromocytoma / surgery. Robotics / instrumentation

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  • (PMID = 18999978.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Takasu N, Hayashi M, Takara M, Iha T, Kouki T, Ohshiro Y, Ogawa Y: False-positive 123I-metaiodobenzylguanidine (MIBG) scan in a patient with angiomyolipoma; positive MIBG scan does not necessarily indicate the presence of pheochromocytoma. Intern Med; 2007;46(20):1717-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] False-positive 123I-metaiodobenzylguanidine (MIBG) scan in a patient with angiomyolipoma; positive MIBG scan does not necessarily indicate the presence of pheochromocytoma.
  • The tumors, which accumulated 123I-MIBG, had been thought to be adrenal pheochromocytoma before surgery.
  • 123I-MIBG-accumulation in AML led to a false-positive diagnosis of adrenal pheochromocytoma.
  • Catecholamine levels had been normal.
  • No chromaffin cells were found in the histological examination of the tumors.
  • MIBG accumulation does not necessarily indicate the presence of pheochromocytoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Gland Neoplasms / radionuclide imaging. Angiomyolipoma / radionuclide imaging. Pheochromocytoma / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adult. Diagnosis, Differential. False Positive Reactions. Female. Humans. Magnetic Resonance Angiography. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 17938527.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine
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61. Gupta NP, Kumar R, Tandon S: Simultaneous laparoscopic adrenalectomy for pheochromocytoma and dismembered pyeloplasty for uretero-pelvic junction obstruction. J Laparoendosc Adv Surg Tech A; 2005 Aug;15(4):405-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous laparoscopic adrenalectomy for pheochromocytoma and dismembered pyeloplasty for uretero-pelvic junction obstruction.
  • Laparoscopic adrenalectomy for pheochromocytoma and laparoscopic dismembered pyeloplasty are both technically difficult procedures.
  • We describe the case of a 61-year-old female patient who presented with a right adrenal pheochromocytoma and bilateral pelvi-ureteric junction obstruction with renal failure who underwent a successful simultaneous transperitoneal laparoscopic adrenalectomy and pyeloplasty.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Pheochromocytoma / surgery. Ureteral Obstruction / surgery

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  • (PMID = 16108746.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Stevenson S, Ramani V, Nasim A: Extra-adrenal pheochromocytoma: an unusual cause of deep vein thrombosis. J Vasc Surg; 2005 Sep;42(3):570-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal pheochromocytoma: an unusual cause of deep vein thrombosis.
  • We report a case of extra-adrenal pheochromocytoma within the organ of Zuckerkandl that presented initially with a left iliofemoral deep venous thrombosis (DVT).
  • Subsequently, because of a series of medical events, the patient was further investigated.
  • This led to a diagnosis of extra-adrenal pheochromocytoma.
  • We discuss the management of patients presenting with DVT, the nature of pheochromocytoma within the organ of Zuckerkandl, and problems relating to its diagnosis.
  • [MeSH-major] Para-Aortic Bodies. Pheochromocytoma / complications. Venous Thrombosis / etiology
  • [MeSH-minor] Diagnosis, Differential. Humans. Iliac Vein. Magnetic Resonance Imaging. Male. Middle Aged. Phlebography. Tomography, X-Ray Computed


63. Gustin AF, Lee EY: Extra-adrenal pheochromocytoma in an adolescent. Pediatr Radiol; 2006 Nov;36(11):1219
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal pheochromocytoma in an adolescent.
  • [MeSH-major] Pheochromocytoma / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • [Cites] Radiographics. 2004 Oct;24 Suppl 1:S87-99 [15486252.001]
  • [Cites] AJR Am J Roentgenol. 2005 Mar;184(3):860-7 [15728610.001]
  • (PMID = 16912895.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5001-33-2 / Metanephrine
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64. Baldisserotto M, Peletti AB, Angelo de Araújo M, Pertence AP, Dora MD, Maciel EO, Gaiger AM: Beckwith-Wiedemann syndrome and bilateral adrenal pheochromocytoma: sonography and MRI findings. Pediatr Radiol; 2005 Nov;35(11):1132-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Beckwith-Wiedemann syndrome and bilateral adrenal pheochromocytoma: sonography and MRI findings.
  • Beckwith-Wiedemann syndrome is characterized by a group of clinical abnormalities, the most frequent of which are omphalocele, macroglossia, gigantism, neonatal hypoglycemia and umbilical hernia.
  • The association of this syndrome with malignant tumors is well documented.
  • We report a child with this syndrome associated with bilateral adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnostic imaging. Adrenal Gland Neoplasms / pathology. Beckwith-Wiedemann Syndrome / diagnostic imaging. Beckwith-Wiedemann Syndrome / pathology. Pheochromocytoma / diagnostic imaging. Pheochromocytoma / pathology
  • [MeSH-minor] Carcinoma / diagnostic imaging. Carcinoma / pathology. Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging / methods. Male. Neuroblastoma / diagnostic imaging. Neuroblastoma / pathology. Radiography. Severity of Illness Index. Ultrasonography / methods


65. Li C, Xu YM: Spontaneous intraperitoneal bleeding caused by adrenal pheochromocytoma. Chin Med J (Engl); 2009 Sep 20;122(18):2193-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous intraperitoneal bleeding caused by adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / physiopathology. Hemorrhage / etiology. Peritoneal Diseases / etiology. Pheochromocytoma / complications. Pheochromocytoma / physiopathology


66. Miller C, Elkas JC: Conservative management of extra-adrenal pheochromocytoma during pregnancy. Obstet Gynecol; 2005 Oct;106(4):868
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of extra-adrenal pheochromocytoma during pregnancy.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Pheochromocytoma / therapy. Pregnancy Complications, Neoplastic / therapy


67. Nicoleau A, Siskind S, Resta C, Noordhoorn M, Turner J, Saw D: Extra-adrenal pheochromocytoma 12 years in the making. Intern Med J; 2008 Jan;38(1):68-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal pheochromocytoma 12 years in the making.
  • [MeSH-major] Pheochromocytoma / pathology. Pheochromocytoma / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Follow-Up Studies. Humans. Hypertension / diagnosis. Hypertension / etiology. Immunohistochemistry. Laparotomy / methods. Male. Neoplasm Staging. Risk Assessment. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Vena Cava, Inferior / pathology

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  • (PMID = 18190420.001).
  • [ISSN] 1445-5994
  • [Journal-full-title] Internal medicine journal
  • [ISO-abbreviation] Intern Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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68. Mathew BK, Bandgar T, Menon PS, Shah NS: Carotid body tumours: three case reports. Singapore Med J; 2009 Feb;50(2):e58-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A carotid body tumour is a rare presentation of an extra-adrenal pheochromocytoma.
  • We report three cases of carotid body paraganglioma, their evaluation, management and the final outcome.
  • [MeSH-major] Carotid Body Tumor / diagnosis. Carotid Body Tumor / pathology. Head and Neck Neoplasms / diagnosis. Paraganglioma / diagnosis. Pheochromocytoma / diagnosis

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  • (PMID = 19296012.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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69. Kim JJ, Valdes SO, Kertesz NJ, Cannon BC: Isolated junctional tachycardia in a patient with pheochromocytoma: an unusual presentation of an uncommon disease. Pediatr Cardiol; 2008 Sep;29(5):986-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated junctional tachycardia in a patient with pheochromocytoma: an unusual presentation of an uncommon disease.
  • Pheochromocytoma is a rare disease, which often presents a diagnostic challenge due to a variable symptom presentation complex.
  • We report the case of a child who presented with isolated symptoms of palpitations and was found to have junctional tachycardia with subsequent development of cardiomyopathy.
  • Further evaluation revealed that she had an extra-adrenal pheochromocytoma, which was the cause of her arrhythmia and subsequent symptomatology.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / complications. Retroperitoneal Neoplasms / complications. Tachycardia, Ectopic Junctional / etiology

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  • [Cites] Acta Cardiol. 1998;53(4):227-9 [9842409.001]
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  • (PMID = 17990020.001).
  • [ISSN] 0172-0643
  • [Journal-full-title] Pediatric cardiology
  • [ISO-abbreviation] Pediatr Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


70. Zhou W, Ding SF: Concurrent pheochromocytoma, ventricular tachycardia, left ventricular thrombus, and systemic embolization. Intern Med; 2009;48(12):1015-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent pheochromocytoma, ventricular tachycardia, left ventricular thrombus, and systemic embolization.
  • An obese 43-year-old female with a right adrenal pheochromocytoma is described.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Embolism / complications. Pheochromocytoma / complications. Tachycardia, Ventricular / complications. Thrombosis / complications


71. Chen L, Li F, Zhuang H, Jing H, Du Y, Zeng Z: Cardiac pheochromocytomas detected by Tc-99m-hydrazinonicotinyl-Tyr3-octreotide (HYNIC-TOC) scintigraphy. Clin Nucl Med; 2007 Mar;32(3):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac pheochromocytomas detected by Tc-99m-hydrazinonicotinyl-Tyr3-octreotide (HYNIC-TOC) scintigraphy.
  • Primary pheochromocytomas of the heart are extremely rare tumors and difficult to diagnose.
  • Iodine labeled metaiodobenzylguanidine (MIBG) is the first choice of the nuclear medicine modality in the evaluation of adrenal pheochromocytoma.
  • However, the sensitivity of MIBG in the diagnosis of extraadrenal pheochromocytoma is less optimal.
  • In this preliminary report, the efficacy of octreotide scintigraphy using Tc-99m labeled hydrazinonicotinyl-Tyr3-octreotide (HYNIC-TOC) in the evaluation of primary cardiac pheochromocytoma was assessed.
  • [MeSH-major] Heart Neoplasms / radionuclide imaging. Octreotide / analogs & derivatives. Organotechnetium Compounds. Pheochromocytoma / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Retrospective Studies

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  • (PMID = 17314591.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m-tricine-hydrazinonicotinyl-Phe(1)-Tyr(3)-octreotide; RWM8CCW8GP / Octreotide
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72. Kasliwal MK, Sharma MS, Vaishya S, Sharma BS: Metachronous pheochromocytoma metastasis to the upper dorsal spine-6-year survival. Spine J; 2008 Sep-Oct;8(5):845-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous pheochromocytoma metastasis to the upper dorsal spine-6-year survival.
  • BACKGROUND CONTEXT: Malignant pheochromocytoma is a rare neoplasm of chromaffin tissue.
  • Very few cases of malignant adrenal pheochromocytoma metastatic to vertebrae exist.
  • PURPOSE: To determine the prognosis of a patient with an excised adrenal pheochromocytoma and a single metachronous metastasis to the upper dorsal spine.
  • STUDY DESIGN: Case report METHODS: The authors report a patient who underwent total excision of an adrenal pheochromocytoma of the left adrenal gland in 2000 who developed a single metastasis to the second dorsal vertebra in 2002 with no evidence of abdominal recurrence.
  • CONCLUSIONS: Patients with adrenal pheochromocytomas must be screened periodically with whole body imaging despite normal abdominal imaging as there is a definite risk of metachronous metastasis.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Pheochromocytoma / secondary. Spinal Neoplasms / secondary

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  • (PMID = 18024223.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y: Radiation dose estimation using preclinical imaging with I124-metaiodobenzylguanidine (MIBG) PET. Med Phys; 2010 Sep;37(9):4861-4867

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: A pretherapyI124-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT) provides a potential method to estimate radiation dose to normal organs, as well as tumors prior to I131-MIBG treatment of neuroblastoma or pheochromocytoma.

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  • [Copyright] © 2010 American Association of Physicists in Medicine.
  • (PMID = 28524557.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Anatomy / Cancer / Computed tomography / Dosimetry / Heart / Liver / Medical imaging / PET / Positron emission tomography / Positron emission tomography (PET) / Radioactivity / Registration / Tissues / dosimetry / image registration / iodine-124 / metaiodobenzylguanidine (MIBG) / neuroblastoma / positron emission tomography / tumours
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74. Jeck-Thole S, Wagner W: Betahistine : A Retrospective Synopsis of Safety Data. Drug Saf; 2006 Nov;29(11):1049-1059

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Betahistine is a structural analogue of histamine that is prescribed for the treatment of vestibular disorders such as Ménière's disease and the symptomatic treatment of vertigo.
  • Betahistine was reported to be involved in one anaphylactoid reaction and one case of Stevens-Johnson syndrome.
  • ADRs related to the nervous system predominantly reveal heterogeneous events that are not suggestive of a specific adverse reaction profile for betahistine.
  • A total of three cases of neoplasm have been reported.
  • An undiagnosed phaeochromocytoma was suspected.

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  • (PMID = 28357699.001).
  • [ISSN] 1179-1942
  • [Journal-full-title] Drug safety
  • [ISO-abbreviation] Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
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75. Athyal RP, Al-Khawari H, Arun N, Abul F, Patrick J: Urinary bladder paraganglioma in a case of von Hippel-Lindau disease. Australas Radiol; 2007 Oct;51 Spec No.:B67-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urinary bladder paraganglioma in a case of von Hippel-Lindau disease.
  • Pheochromocytoma is a well-known association in patients with von Hippel-Lindau disease.
  • However, extra-adrenal pheochromocytoma or paraganglioma with this association is rare.
  • We describe a patient with von Hippel-Lindau disease who presented with haematuria and was diagnosed to have a urinary bladder paraganglioma, which is an extremely rare tumour.
  • Herein we report this case which, to the best of our knowledge, represents the first case highlighting the association of urinary bladder paraganglioma with von Hippel-Lindau disease.
  • [MeSH-major] Paraganglioma / pathology. Paraganglioma / radiography. Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / radiography. von Hippel-Lindau Disease / pathology. von Hippel-Lindau Disease / radiography

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  • (PMID = 17875164.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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76. Elsayes KM, Leyendecker JR, Narra VR, Brown JJ: Pheochromocytoma of the organ of Zuckerkandl. Unusually small lesion detected with magnetic resonance imaging. Saudi Med J; 2005 Jan;26(1):107-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pheochromocytoma of the organ of Zuckerkandl. Unusually small lesion detected with magnetic resonance imaging.
  • A case report of a 40-year-old female with an unusually small pheochromocytoma of the organ of Zuckerkandl is discussed.
  • The tumor is diagnosed by magnetic resonance imaging MRI examination, which was requested to evaluate her as a potential renal donor.
  • There is a family history of Carney s triad gastric leiomyosarcoma, extra-adrenal pheochromocytoma and pulmonary chondroma.
  • [MeSH-major] Magnetic Resonance Imaging. Para-Aortic Bodies. Pheochromocytoma / diagnosis

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  • (PMID = 15756364.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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77. Lisewski D, Ryan S, Lim EM, Frost F, Nguyen H: Concomitant compostite adrenal phoechromocytoma, multipte gastric stromal tumours and pseudohermaphrodism in a patient with von Recklinghausen's disease. Int Semin Surg Oncol; 2006;3:11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concomitant compostite adrenal phoechromocytoma, multipte gastric stromal tumours and pseudohermaphrodism in a patient with von Recklinghausen's disease.
  • Although pheochromocytoma occurs in 1% of patients with von Recklinghausen's disease, composite tumors in this syndrome are much rarer, with isolated case reports in the literature.
  • Multiple GISTs however, are associated with clinical syndromes particularly von Recklinghausen's disease.
  • We believe this is the first report of composite adrenal pheochromocytoma and multiple GISTs occurring in an 82 year old woman with neurofibromatosis type 1 (NF1), manifested by clitoral and subcutaneous neurofibromas, epilepsy and Lisch nodules.

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  • (PMID = 16640782.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1459175
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78. Chowdhury FU, Scarsbrook AF: Indium-111 pentetreotide uptake within cerebellar hemangioblastoma in von Hippel-lindau syndrome. Clin Nucl Med; 2008 Apr;33(4):294-6
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  • [Title] Indium-111 pentetreotide uptake within cerebellar hemangioblastoma in von Hippel-lindau syndrome.
  • A 38-year-old woman with known von Hippel-Lindau syndrome underwent In-111 pentetreotide (OctreoScan) scintigraphy to evaluate a suspected pancreatic neuroendocrine tumor.
  • The patient had undergone surgical resection of a left adrenal pheochromocytoma and a large right cerebellar hemangioblastoma several years previously.
  • Although there was no evidence for recurrence of pheochromocytoma and no uptake within the pancreatic lesion, there was focal tracer accumulation within the left cerebellar hemisphere.
  • [MeSH-major] Cerebellar Neoplasms / radionuclide imaging. Hemangioblastoma / radionuclide imaging. Somatostatin / analogs & derivatives. von Hippel-Lindau Disease / radionuclide imaging

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  • (PMID = 18356676.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide
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79. Rocchietti March M, De Palma C, L'Angiocola PD, Aliberti G: [Neurofibromatosis type I and hypertension: a case report]. Recenti Prog Med; 2008 Dec;99(12):602-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pheochromocytomas are catecholamine-producing neuroendocrine tumors arising from chromaffine cells derived from the embryonic neural crest.
  • They occur in 0.1-5.7% of patients with neurofibromatosis type 1 (von Recklinghausen's disease).
  • We report the case of an adrenal pheochromocytoma in a patient with neurofibromatosis type 1.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Hypertension / etiology. Neurofibromatosis 1 / complications. Pheochromocytoma / complications

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  • (PMID = 19388218.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Catecholamines
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80. Aggarwal S, Guleria S, Misra MC, Goswami R, Seth A, Kumar S: Transperitoneal, transmesocolic approach for laparoscopic excision of an extra-adrenal pheochromocytoma. J Laparoendosc Adv Surg Tech A; 2006 Jun;16(3):261-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transperitoneal, transmesocolic approach for laparoscopic excision of an extra-adrenal pheochromocytoma.
  • Laparoscopic surgery is an established treatment modality for adrenal disease, especially pheochromocytomas.
  • We describe the successful excision of an extra-adrenal pheochromocytoma using a novel transperitoneal, transmesocolic approach.
  • The tumor was located inferior to the left renal hilum in the para-aortic region and was found bulging through the descending mesocolon at laparoscopy.
  • The tumor was removed without mobilization of the descending colon.
  • [MeSH-major] Laparoscopy / methods. Pheochromocytoma / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16796436.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Nagashima A, Ikemoto I, Furuta N, Egawa S: [A case of pheochromocytoma associated with incidental multiple renal cell carcinoma originating from acquired cystic disease of the kidney in hemodialysis]. Hinyokika Kiyo; 2006 Jul;52(7):557-60
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  • [Title] [A case of pheochromocytoma associated with incidental multiple renal cell carcinoma originating from acquired cystic disease of the kidney in hemodialysis].
  • Computed tomography and magnetic resonance imaging demonstrated the presence of right adrenal tumor(1.5 x 1.5 cm) and bilateral multiple renal cysts.
  • Right adrenal pheochromocytoma was confirmed by elevated serum level of catecholamines and diagnosed by 131I-MIBG scintigram.
  • Histological examination confirmed malignant pheochromocytoma and small multiple renal cell carcinomas.
  • To our knowledge, this is the fifth case of adrenal pheochromocytoma and renal cell carcinoma associated ACDK in a hemodialysis patient in the Japanese literature.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Carcinoma, Renal Cell / diagnosis. Kidney Diseases, Cystic. Kidney Neoplasms / diagnosis. Pheochromocytoma / complications. Renal Dialysis


82. Cabrera Castillo PM, Aguilera Bazán A, Cansino Alcaide JR, Alvarez Maestro M, De la Peña Barthel JJ: [Pheochromocytoma: laparoscopic treatment]. Arch Esp Urol; 2007 Nov;60(9):1.131-3
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  • [Title] [Pheochromocytoma: laparoscopic treatment].
  • [Transliterated title] Feocromocitoma: tratamiento laparoscópico.
  • OBJECTIVE: We report this clinical case not only for the laparoscopic approach of a pheochromocytoma but also because of its particular aggressiveness and oddity of its clinical presentation.
  • METHODS: 44 years old male presenting with oppressive chest pain with accompanying vegetative symptoms, who was diagnosed of right adrenal pheochromocytoma.
  • RESULTS: After the diagnosis of pheochromocytoma was established and double adrenergic blockage implemented, transperitoneal laparoscopic surgery was performed.
  • Pathological analysis of the surgical specimen confirmed the clinical diagnosis of pheochromocytoma.
  • CONCLUSIONS: The laparoscopic approach of adrenal pheochromocytoma is possible and safe in centres with laparoscopic experience, obtaining the same results than open surgery, offering advantages for the patient such as less pain, smaller incisions, and early ambulation, which results in a shorter hospital stay.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Pheochromocytoma / surgery

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  • (PMID = 18077872.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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83. Isobe K, Nissato S, Tatsuno I, Yashiro T, Takekoshi K, Kawakami Y: Expression of mRNAs for succinate dehydrogenase subunits and related genes in pheochromocytoma. Ann N Y Acad Sci; 2006 Aug;1073:253-62
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  • [Title] Expression of mRNAs for succinate dehydrogenase subunits and related genes in pheochromocytoma.
  • Mutations in the genes encoding succinate dehydrogenase (SDH) have been associated with susceptibility to pheochromocytoma.
  • In this study, we examined the level of expression of mRNAs encoding SDHB, SDHC, and SDHD in pheochromocytoma, pheochromocytoma subgroups, and normal adrenal gland, and compared the expression of these genes to the level of expression of related genes in the same tissues.
  • The mean relative level of expression of SDHB, SDHC, SDHD and VHL mRNA was 28.7+/-6.2%, 16.6+/-4.8%, 214+/-47.5% and 25.9+/-8.2%, respectively, in pheochromocytoma tissues compared to normal adrenal gland.
  • Furthermore, the mean relative level of the RET proto-oncogene mRNA was 707+/-149% in pheochromocytoma compared to normal adrenal gland.
  • In multiple endocrine neoplasia (MEN) 2a, the expression of the SDH genes and VHL mRNA was significantly higher than that observed in adrenal or extra-adrenal pheochromocytoma.
  • The expression of the corticotropin-releasing hormone (CRH) mRNA was significantly higher in extra-adrenal pheochromocytoma than in adrenal pheochromocytoma or MEN2a.
  • Thus, tumor-specific gene expression exists in pheochromocytoma, which may explain the characteristics of the tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics. RNA, Messenger / genetics. Succinate Dehydrogenase / genetics

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  • (PMID = 17102093.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 1.3.99.1 / Succinate Dehydrogenase
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84. Montoya-Martínez G, Moreno-Palacios J, Serrano-Brambila E: [Lumboscopic adrenalectomy for pheochromocytoma in a patient with multiple endocrine neoplasia type 2B]. Cir Cir; 2009 Mar-Apr;77(2):131-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lumboscopic adrenalectomy for pheochromocytoma in a patient with multiple endocrine neoplasia type 2B].
  • [Transliterated title] Adrenalectomía lumboscópica en un paciente con feocromocitoma y neoplasia endocrina múltiple tipo 2B.
  • Multiple endocrine neoplasia type 2B (MEN 2B) is an autosomal dominant syndrome characterized by medullary thyroid carcinoma, pheochromocytoma, a marfanoid habitus and mucosal ganglioneuromatosis.
  • We present a case of a 35-year-old male with MEN 2B with right adrenal pheochromocytoma diagnosed biochemically and radiologically and treated by laparoscopic adrenalectomy.
  • Diagnosis of pheochromocytoma includes detection of catecholamines in urine and plasma and radiological tests such as computed axial tomography, nuclear magnetic resonance imaging and metaiodobenzylguanidine scintigraphy.
  • Laparoscopic techniques have become standard for treatment of tumors of the adrenal glands.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Multiple Endocrine Neoplasia Type 2b. Neoplasms, Multiple Primary. Pheochromocytoma / surgery


85. Bouhouch A, Hendriks JM, Lauwers PR, De Raeve HR, Van Schil PE: Asymptomatic pheochromocytoma in the posterior mediastinum. Acta Chir Belg; 2007 Jul-Aug;107(4):465-7
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  • [Title] Asymptomatic pheochromocytoma in the posterior mediastinum.
  • A 66-year-old female patient was treated for a posterior mediastinal tumour with unknown histology.
  • The tumour was completely resected.
  • Pathology revealed an extra-adrenal pheochromocytoma.
  • Diagnosis of pheochromocytoma is usually made on the basis of clinical presentation and elevated catecholamine levels in serum or urine.
  • Complete surgical excision is the primary treatment.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Mediastinum. Pheochromocytoma / pathology

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  • (PMID = 17966552.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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86. Ba Arah BT: A case of von Hippel-Lindau disease with exudative maculopathy. Oman J Ophthalmol; 2009 May;2(2):82-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of von Hippel-Lindau disease with exudative maculopathy.
  • Von Hippel-Lindau (VHL) disease is a rare multisystem familial tumor syndrome of autosomal dominant inheritance.
  • Hallmark lesions include retinal, cerebellum and spinal cord hemangioblastomas, renal cell carcinomas, adrenal pheochromocytomas, angiomatous or cystic lesions of the kidneys, pancreas, and epididymis.
  • We report a case of VHL disease in a 26-year-old patient who presented with exudative macular edema.
  • Ocular and systemic studies revealed the presence of retinal and central nervous system hemangioblastomas, adrenal pheochromocytoma, multiple pancreatic, and kidney cysts.

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  • (PMID = 20671835.001).
  • [ISSN] 0974-7842
  • [Journal-full-title] Oman journal of ophthalmology
  • [ISO-abbreviation] Oman J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2905185
  • [Keywords] NOTNLM ; Argon laser / cryotherapy / hemangioblastoma / von Hippel-Lindau disease
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87. Yashiro T, Yasufuku K, Hiroshima K, Fujisawa T: Successful surgical treatment for life threatening metastatic thoracic and cervical pheochromocytoma. Interact Cardiovasc Thorac Surg; 2005 Feb;4(1):75-6
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  • [Title] Successful surgical treatment for life threatening metastatic thoracic and cervical pheochromocytoma.
  • A 53 year-old woman had been followed up since 1996 after receiving bilateral adrenalectomy for the treatment of bilateral adrenal pheochromocytoma in von Hippel-Lindau (VHL) disease.
  • Tumor progression was suspected to occlude the left main pulmonary artery and hormonal assays showed elevated levels of the plasma norepinephrine, which may cause fatal complications.
  • Percutaneous needle biopsy of the left cervical tumor revealed metastatic pheochromocytoma.
  • After embolization of the main feeding artery, surgical resection of the tumor resulted in control of excess catecholamine release and symptoms.

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  • (PMID = 17670360.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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88. Molatore S, Liyanarachchi S, Irmler M, Perren A, Mannelli M, Ercolino T, Beuschlein F, Jarzab B, Wloch J, Ziaja J, Zoubaa S, Neff F, Beckers J, Höfler H, Atkinson MJ, Pellegata NS: Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma. Proc Natl Acad Sci U S A; 2010 Oct 26;107(43):18493-8
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  • [Title] Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma.
  • Pheochromocytomas are rare neoplasias of neural crest origin arising from chromaffin cells of the adrenal medulla and sympathetic ganglia (extra-adrenal pheochromocytoma).
  • Pheochromocytoma that develop in rats homozygous for a loss-of-function mutation in p27Kip1 (MENX syndrome) show a clear progression from hyperplasia to tumor, offering the possibility to gain insight into tumor pathobiology.
  • We compared the gene-expression signatures of both adrenomedullary hyperplasia and pheochromocytoma with normal rat adrenal medulla.
  • Hyperplasia and tumor show very similar transcriptome profiles, indicating early determination of the tumorigenic signature.
  • Overexpression of these genes precedes histological changes in affected adrenal glands.
  • Adrenal and extra-adrenal pheochromocytoma development clearly follows diverged molecular pathways in MENX rats.
  • To correlate these findings to human pheochromocytoma, we studied nine genes overexpressed in the rat lesions in 46 sporadic and familial human pheochromocytomas.
  • Immunohistochemical staining detected high L1CAM expression selectively in 27 human pheochromocytomas but not in 140 nonchromaffin neuroendocrine tumors.
  • These studies reveal clues to the molecular pathways involved in rat and human pheochromocytoma and identify previously unexplored biomarkers for clinical use.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Multiple Endocrine Neoplasia / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Adrenal Medulla / metabolism. Adrenal Medulla / pathology. Animals. Base Sequence. Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase Inhibitor p27 / genetics. DNA Primers / genetics. Disease Models, Animal. Gene Expression Profiling. Homeodomain Proteins / genetics. Humans. Hyperplasia. Neural Cell Adhesion Molecule L1 / genetics. PC12 Cells. Paraganglioma / genetics. Rats. Rats, Mutant Strains. Species Specificity

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  • (PMID = 20937862.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE21006
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cdkn1b protein, rat; 0 / DNA Primers; 0 / Homeodomain Proteins; 0 / Neural Cell Adhesion Molecule L1; 0 / PHOX2A protein, human; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ PMC2972990
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89. Liu L, Mei J, Che G: Asymptomatic paraganglioma of the posterior mediastinum misdiagnosed until operation. Thorac Cardiovasc Surg; 2010 Aug;58(5):302-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic paraganglioma of the posterior mediastinum misdiagnosed until operation.
  • A 23-year-old female patient was treated for a posterior mediastinal tumor of unknown histology.
  • Her systemic blood pressure increased rapidly to a critical level immediately after starting surgical manipulation of the tumor, which was suggestive of a hyperfunctioning pheochromocytoma.
  • The tumor was removed after controlling the blood pressure and was histologically diagnosed as an extra-adrenal pheochromocytoma.
  • Further postoperative investigations showed the tumor to be a sporadic type through further postoperative investigations and the patient had subsequently an uneventful course.
  • [MeSH-major] Diagnostic Errors. Mediastinal Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis. Thoracotomy
  • [MeSH-minor] Antihypertensive Agents / administration & dosage. Blood Pressure. Female. Humans. Hypertension / etiology. Hypertension / physiopathology. Intraoperative Care. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • [Copyright] Copyright (c) Georg Thieme Verlag KG Stuttgart-New York.
  • (PMID = 20680909.001).
  • [ISSN] 1439-1902
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antihypertensive Agents
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90. Musuraca G, Imperadore F, Terraneo C, Vaccarini C, Prati D, Centonze M, Vergara G: Pheochromocytoma mimicking a non-ST elevation acute myocardial infarction. Cardiol J; 2009;16(4):355-7
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pheochromocytoma mimicking a non-ST elevation acute myocardial infarction.
  • We report a 57 year-old male patient admitted with a diagnosis of non-ST elevation acute myocardial infarction.
  • Eventually, a left adrenal pheochromocytoma was discovered.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Chest Pain / diagnosis. Myocardial Infarction / diagnosis. Pheochromocytoma / diagnosis
  • [MeSH-minor] Adrenalectomy. Diagnosis, Differential. Echocardiography. Electrocardiography. Humans. Hypertension / diagnosis. Male. Middle Aged. Tomography, X-Ray Computed


91. Chang H, Xu L, Mu Q: Primary functioning hepatic paraganglioma: a case report. Adv Ther; 2006 Sep-Oct;23(5):817-20
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  • [Title] Primary functioning hepatic paraganglioma: a case report.
  • An extra-adrenal pheochromocytoma is known as a paraganglioma.
  • This report describes a patient with a rare primary functioning hepatic paraganglioma that resulted in hypertension.
  • The imaging characteristics and therapeutic principles of this rare tumor were gleaned from a review of the literature.
  • Identification of this malignant tumor or possible recurrence is difficult, so longterm follow-up is recommended.
  • [MeSH-major] Hypertension / etiology. Liver Neoplasms / complications. Paraganglioma / complications

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  • (PMID = 17142218.001).
  • [ISSN] 0741-238X
  • [Journal-full-title] Advances in therapy
  • [ISO-abbreviation] Adv Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Wang X, Liang L, Jiang Y: Nine cases of childhood adrenal tumour presenting with hypertension and a review of the literature. Acta Paediatr; 2007 Jun;96(6):930-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nine cases of childhood adrenal tumour presenting with hypertension and a review of the literature.
  • AIM: To describe the clinical features, treatment and outcome of children adrenal tumors presenting with hypertension.
  • METHODS: The records of nine children under 16 years of age with adrenal tumours presenting with hypertension were analysed.
  • RESULTS: Abdominal mass was palpable only in one patient at diagnosis.
  • Besides hypertension-associated symptoms, Cushing's syndrome was the common presentation form (n = 4).
  • Abdominal computed topography showed adrenal mass in all patients.
  • The median tumour weight was 73 g (11-530 g) and the size ranged from 1.5 x 1.5 to 12 x 14 cm2.
  • Pheochromocytoma (n = 2), adrenocortical adenoma (n = 3), adrenocortical carcinoma (n = 1), neuroblastoma (n = 2) and ganglioneuromas (n = 1) were found.
  • In one case, adrenal pheochromocytoma first occurred and non-functioning islet cell tumour successively occurred at pancreas.
  • CONCLUSIONS: Childhood adrenal tumours presented with hypertension showed an atypical course, variable presentation.
  • We report a unique case of adrenal pheochromocytoma followed by the occurrence of non-functioning islet cell tumour.
  • Imaging techniques are important to detect adrenal tumours.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Hypertension / etiology. Pheochromocytoma / complications
  • [MeSH-minor] Adolescent. Adrenocorticotropic Hormone / blood. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Longitudinal Studies. Male. Retrospective Studies. Treatment Outcome. Vanilmandelic Acid / blood


93. Paulin FL, Klein GJ, Gula LJ, Skanes AC, Yee R, Krahn AD: QT prolongation and monomorphic VT caused by pheochromocytoma. J Cardiovasc Electrophysiol; 2009 Aug;20(8):931-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] QT prolongation and monomorphic VT caused by pheochromocytoma.
  • INTRODUCTION: Pheochromocytoma may present with ECG abnormalities as one of the few clues to the diagnosis.
  • Investigations revealed an adrenal pheochromocytoma.
  • Her QTc normalized after excision of the tumor.
  • CONCLUSION: Pheochromocytoma may induce monomorphic VT and QT prolongation.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Long QT Syndrome / etiology. Pheochromocytoma / complications. Tachycardia, Ventricular / etiology

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  • (PMID = 19207773.001).
  • [ISSN] 1540-8167
  • [Journal-full-title] Journal of cardiovascular electrophysiology
  • [ISO-abbreviation] J. Cardiovasc. Electrophysiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Podolsky ER, Feo L, Brooks AD, Castellanos A: Robotic resection of pheochromocytoma in the second trimester of pregnancy. JSLS; 2010 Apr-Jun;14(2):303-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Robotic resection of pheochromocytoma in the second trimester of pregnancy.
  • Pheochromocytoma is a rare neuroendocrine tumor diagnosed in 1:50,000 pregnancies.
  • Normal physiologic changes associated with pregnancy often make early recognition difficult and diagnosis delayed.
  • This case of a 34-year African-American female diagnosed with an adrenal pheochromocytoma during her second trimester of pregnancy is the first reported case of successful robotic resection.

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  • [Cites] Clin Obstet Gynecol. 2003 Mar;46(1):92-7 [12686898.001]
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  • (PMID = 20949656.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3043591
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95. Al-Natour S, Sawalhi S, Al-Muhtady D, Hijazi E: Mesenteric Castleman's disease: case report and literature review. Asian J Surg; 2010 Jul;33(3):150-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric Castleman's disease: case report and literature review.
  • A 131I-meta-iodobenzylguanidine whole body scan was reported as normal, which ruled out the possibility of extra-adrenal pheochromocytoma.
  • No definitive preoperative diagnosis could be established.
  • Surgical resection of the tumour revealed mesenteric Castleman's disease, hyaline vascular type.
  • Such a diagnosis should be considered for any abdominal vascular mass.

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  • [Copyright] Copyright © 2010 Asian Surgical Association. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21163413.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
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96. Peczkowska M, Cascon A, Prejbisz A, Kubaszek A, Cwikła BJ, Furmanek M, Erlic Z, Eng C, Januszewicz A, Neumann HP: Extra-adrenal and adrenal pheochromocytomas associated with a germline SDHC mutation. Nat Clin Pract Endocrinol Metab; 2008 Feb;4(2):111-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal and adrenal pheochromocytomas associated with a germline SDHC mutation.
  • The patient had undergone surgery for a retroperitoneal tumor at the age of 31 years, when histological examination revealed an extra-adrenal pheochromocytoma.
  • The patient's 68-year-old mother had a history of a carotid body tumor, which had been resected when she was 34 years old.
  • She was diagnosed with a meningioma at 54 years of age and a jugular paraganglioma at 68 years of age.
  • INVESTIGATIONS: A 24h urine catecholamine assay was performed.
  • CT imaging of the abdomen and (123)I-labeled metaiodobenzylguanidine scintigraphy revealed a right pheochromocytoma and left adrenal incidentaloma.
  • An inherited neoplasia syndrome was suspected and molecular genetic analyses were performed.
  • DIAGNOSIS: Right adrenal pheochromocytoma and left adrenal nonfunctioning incidentaloma, as part of a familial pheochromocytoma-paraganglioma syndrome associated with a germline mutation in SDHC (gene encoding succinate dehydrogenase complex, subunit C, integral membrane protein, 15 kDa).
  • Management included surgical resection of the existing pheochromocytoma.
  • The patient continues to be monitored with MRI scans of the neck, thorax, abdomen and pelvis every 1-2 years and an annual 24h urine collection for the measurement of metanephrines and catecholamines.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Germ-Line Mutation. Membrane Proteins / genetics. Pheochromocytoma / pathology

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  • (PMID = 18212813.001).
  • [ISSN] 1745-8374
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / R01HD39058-01; United States / NICHD NIH HHS / HD / R01HD39058-01S1
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Membrane Proteins; 0 / SDHC protein, human; 5001-33-2 / Metanephrine
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97. Barontini M, Levin G, Sanso G: Characteristics of pheochromocytoma in a 4- to 20-year-old population. Ann N Y Acad Sci; 2006 Aug;1073:30-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characteristics of pheochromocytoma in a 4- to 20-year-old population.
  • Hypertension in children and adolescents has become a major health problem recently recognized, and in a significant number of patients it is due to an endocrine tumor.
  • The aim of this study was to establish the characteristics of pheochromocytoma in a population of 58 patients between 4 and 20 years of age studied at our Center.
  • They represented a 23% of the total population of 255 pheochromocytoma patients studied.
  • The youngsters studied showed a higher incidence of bilateral adrenal pheochromocytoma (34%) and extra-adrenal pheochromocytoma (22%).
  • In addition, the incidence of familial pheochromocytoma was elevated in these patients (39%).
  • Surprisingly, in contrast with the adult population where the most frequent familial pheochromocytomas were multiple endocrine neoplasia (MEN) type 2A (15%), the younger population showed a higher predominance of von Hippel-Lindau (VHL) (28%) and lower incidence of MEN 2A, MEN 2B, neurofibromatosis (NF), and succinate dehydrogenase subunit B (SDHB).
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Pheochromocytoma / pathology

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  • (PMID = 17102069.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Furuta N, Sasaki H, Miki J, Kimura T, Egawa S: [Clinical study of laparoscopic adrenalectomy for adrenal pheochromocytoma]. Hinyokika Kiyo; 2009 May;55(5):245-8
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  • [Title] [Clinical study of laparoscopic adrenalectomy for adrenal pheochromocytoma].
  • The relationship between surgical methods and clinical parameters was analyzed retrospectively in 32 patients operated for adrenal pheochromocytoma (laparoscopic surgery, 13 patients; open surgery, 19 patients) in Jikei University Hospital from 1997 to 2006.
  • The mean tumor size was higher in open surgery patients.
  • Tumor size did not show a significant correlation with either duration of surgery or blood loss.
  • After considering factors such as tumor size, hormone activity, preoperative management, and surgeon's skill, we believe that compared to open surgery, laparoscopic surgery is a less invasive and more useful method for adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Pheochromocytoma / surgery
  • [MeSH-minor] Adrenergic alpha-Antagonists / administration & dosage. Adult. Aged. Aged, 80 and over. Blood Loss, Surgical / statistics & numerical data. Female. Humans. Hypertension / drug therapy. Hypertension / etiology. Male. Middle Aged. Preoperative Care. Retrospective Studies. Time Factors

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  • (PMID = 19507540.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adrenergic alpha-Antagonists
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99. Timmers HJ, Hadi M, Carrasquillo JA, Chen CC, Martiniova L, Whatley M, Ling A, Eisenhofer G, Adams KT, Pacak K: The effects of carbidopa on uptake of 6-18F-Fluoro-L-DOPA in PET of pheochromocytoma and extraadrenal abdominal paraganglioma. J Nucl Med; 2007 Oct;48(10):1599-606
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  • [Title] The effects of carbidopa on uptake of 6-18F-Fluoro-L-DOPA in PET of pheochromocytoma and extraadrenal abdominal paraganglioma.
  • Whether carbidopa also improves (18)F-DOPA PET of adrenal pheochromocytomas and extraadrenal paragangliomas is unknown.
  • The aim of this study was to investigate the sensitivity of (18)F-DOPA PET in the detection of paraganglioma and its metastatic lesions and to evaluate whether tracer uptake by the tumors is enhanced by carbidopa.
  • METHODS: Two patients with nonmetastatic adrenal pheochromocytoma, and 9 patients with extraadrenal abdominal paraganglioma (1 nonmetastatic, 8 metastatic), underwent whole-body CT, MRI, baseline (18)F-DOPA PET, and (18)F-DOPA PET with oral preadministration of 200 mg of carbidopa.
  • Carbidopa increased the mean (+/-SD) peak standardized uptake value in index tumor lesions from 6.4 +/- 3.9 to 9.1 +/- 5.6 (P = 0.037).
  • Pancreatic physiologic (18)F-DOPA uptake, which may mask adrenal pheochromocytoma, is blocked by carbidopa.
  • CONCLUSION: Carbidopa enhances the sensitivity of (18)F-DOPA PET for adrenal pheochromocytomas and extraadrenal abdominal paragangliomas by increasing the tumor-to-background ratio of tracer uptake.
  • The sensitivity of (18)F-DOPA PET for metastases of paraganglioma appears to be limited.
  • [MeSH-major] Abdominal Neoplasms / metabolism. Adrenal Gland Neoplasms / metabolism. Carbidopa. Dihydroxyphenylalanine / analogs & derivatives. Paraganglioma, Extra-Adrenal / metabolism. Pheochromocytoma / metabolism. Positron-Emission Tomography / methods

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  • [CommentIn] J Nucl Med. 2007 Oct;48(10):1577-9 [17909255.001]
  • (PMID = 17873132.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 2C598205QX / fluorodopa F 18; 63-84-3 / Dihydroxyphenylalanine; MNX7R8C5VO / Carbidopa
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100. Tobe M, Ito K, Umeda S, Sato A, Adaniya N, Tanaka Y, Hayakawa M, Asano T: Severe polyuria after the resection of adrenal pheochromocytoma. Int J Urol; 2010 Dec;17(12):1004-7
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  • [Title] Severe polyuria after the resection of adrenal pheochromocytoma.
  • A 73-year-old male patient with hypertension and hyperglycemia was referred to our hospital because of a diagnosis regarding his left adrenal tumor.
  • Because the levels of urinary metanephrine and normetanephrine were elevated, and (131) I-MIBG scintigraphy showed intense uptake in the adrenal tumor, the tumor was diagnosed as a pheochromocytoma.
  • Plasma antidiuretic hormone (ADH) levels were within the normal range.
  • Plasma human atrial natriuretic peptide (hANP) and brain natriuretic peptide (BNP) were elevated postoperatively, and the elevation of these peptides was one possible cause for the severe polyuria.
  • Because ADH levels in the tumor fluid were not elevated, the tumor was not an ADH-secreting tumor.
  • However, the mechanism of polyuria after the resection of adrenal pheochromocytoma is not fully understood.
  • Polyuria after the resection of adrenal pheochromocytoma is extremely rare, and the present subject is the second case to date.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / adverse effects. Pheochromocytoma / surgery. Polyuria / etiology. Postoperative Complications / etiology

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  • [Copyright] © 2010 The Japanese Urological Association.
  • (PMID = 20874817.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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