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1. Sibal L, Jovanovic A, Agarwal SC, Peaston RT, James RA, Lennard TW, Bliss R, Batchelor A, Perros P: Phaeochromocytomas presenting as acute crises after beta blockade therapy. Clin Endocrinol (Oxf); 2006 Aug;65(2):186-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Phaeochromocytoma crisis is a life-threatening emergency that may be undiagnosed because of its numerous, nonspecific manifestations.
  • We analysed, retrospectively, the presentation, management and outcome of patients who were admitted to our institution with phaeochromocytoma crises over a 5-year period.
  • RESULTS: Five patients (two males, three females; mean age 34.6 years, range 19-51 years) who presented as emergencies requiring intensive care, with multiple non-specific manifestations and previously undiagnosed pheochromocytoma, were identified.
  • Initiation of beta blockers in four patients was associated with further deterioration in haemodynamic status, labile blood pressure and cardiac arrhythmias, which led to the diagnosis of the underlying phaeochromocytoma.
  • Following intensive supportive therapy and alpha blockade, all five patients recovered and underwent elective surgical removal of phaeochromocytoma, uneventfully.
  • CONCLUSION: Unexplained cardiopulmonary dysfunction, particularly after the institution of beta blockers, should alert clinicians to the possibility of phaeochromocytoma.
  • A high index of suspicion is essential to reduce morbidity and mortality in these patients through early diagnosis and aggressive management.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenergic beta-Antagonists / adverse effects. Cardiomyopathies / complications. Metoprolol / adverse effects. Pheochromocytoma / complications
  • [MeSH-minor] Acute Disease. Adrenalectomy. Adult. Catecholamines / urine. Emergencies. Female. Humans. Male. Metanephrine / urine. Middle Aged. Multiple Endocrine Neoplasia Type 2a / complications. Multiple Endocrine Neoplasia Type 2a / surgery. Pneumonia / complications. Pneumonia / surgery. Tomography, X-Ray Computed

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  • (PMID = 16886958.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Catecholamines; 5001-33-2 / Metanephrine; GEB06NHM23 / Metoprolol
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2. Perlmutter AE, Livengood R, Zaslau S, Farivar-Mohseni H: Periprostatic pheochromocytoma. Urology; 2005 Jul;66(1):194
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periprostatic pheochromocytoma.
  • In adults, 10% of pheochromocytomas are extra-adrenal.
  • Most extra-adrenal pheochromocytomas occur in the organ of Zuckerkandl.
  • Occasionally, pheochromocytomas can arise from paraganglion chromaffin cells in other locations.
  • We present the case of a 63-year-old hypertensive man with a periprostatic pheochromocytoma.
  • Our patient underwent surgical extirpation of the pheochromocytoma, while sparing the prostate from resection.
  • [MeSH-major] Pheochromocytoma. Prostatic Neoplasms


3. van Nederveen FH, Korpershoek E, Lenders JW, de Krijger RR, Dinjens WN: Somatic SDHB mutation in an extraadrenal pheochromocytoma. N Engl J Med; 2007 Jul 19;357(3):306-8
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  • [Title] Somatic SDHB mutation in an extraadrenal pheochromocytoma.
  • [MeSH-major] Iron-Sulfur Proteins / genetics. Loss of Heterozygosity. Pheochromocytoma / genetics. Succinate Dehydrogenase / genetics. Urinary Bladder Neoplasms / genetics

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  • (PMID = 17634472.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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4. Hackenberg C, Engelhardt A, Matthijs HC, Wittink F, Bauwe H, Kaplan A, Hagemann M: Photorespiratory 2-phosphoglycolate metabolism and photoreduction of O2 cooperate in high-light acclimation of Synechocystis sp. strain PCC 6803. Planta; 2009 Sep;230(4):625-37
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  • [Title] Photorespiratory 2-phosphoglycolate metabolism and photoreduction of O2 cooperate in high-light acclimation of Synechocystis sp. strain PCC 6803.
  • In cyanobacteria, photorespiratory 2-phosphoglycolate (2PG) metabolism is mediated by three different routes, including one route involving the glycine decarboxylase complex (Gcv).
  • Single and double mutants defective in these processes were constructed to investigate the relation between photorespiratory 2PG-metabolism and the photoreduction of O(2) in the cyanobacterium Synechocystis sp. PCC 6803.
  • [MeSH-minor] Aerobiosis / drug effects. Aerobiosis / radiation effects. Carbon Dioxide / pharmacology. Chlorophyll / metabolism. Fluorescence. Gene Expression Regulation, Bacterial. Genes, Bacterial. Genotype. Immunoblotting. Mutation / genetics. Oligonucleotide Array Sequence Analysis. Oxidation-Reduction / drug effects. Oxidation-Reduction / radiation effects. Photosystem II Protein Complex / metabolism

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  • (PMID = 19578872.001).
  • [ISSN] 1432-2048
  • [Journal-full-title] Planta
  • [ISO-abbreviation] Planta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glycolates; 0 / Photosystem II Protein Complex; 1406-65-1 / Chlorophyll; 142M471B3J / Carbon Dioxide; H8593JOP13 / phosphoglycolate; S88TT14065 / Oxygen
  • [Other-IDs] NLM/ PMC2729987
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5. Micheletti E, Pereira S, Mannelli F, Moradas-Ferreira P, Tamagnini P, De Philippis R: Sheathless mutant of Cyanobacterium Gloeothece sp. strain PCC 6909 with increased capacity to remove copper ions from aqueous solutions. Appl Environ Microbiol; 2008 May;74(9):2797-804
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  • [Title] Sheathless mutant of Cyanobacterium Gloeothece sp. strain PCC 6909 with increased capacity to remove copper ions from aqueous solutions.
  • The cyanobacterium Gloeothece sp. strain PCC 6909 and its sheathless mutant were tested for their abilities to remove copper ions from aqueous solutions, with the aim of defining the role of the various outermost polysaccharidic investments in the removal of the metal ions.
  • Microscopy studies and chemical analyses revealed that, although the mutant does not possess a sheath, it releases large amounts of polysaccharidic material (released exocellular polysaccharides [RPS]) into the culture medium.
  • Therefore, the increased copper binding efficiency observed with the sheathless mutant can be attributed to the release of a polysaccharide containing larger amounts and/or more accessible functional groups (e.g., carboxyl and amide groups).

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  • (PMID = 18326679.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ EU499305
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbohydrates; 0 / Polysaccharides, Bacterial; 0 / Solutions; 789U1901C5 / Copper
  • [Other-IDs] NLM/ PMC2394890
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6. Kulkarni M, Joshi SR: Chemical shift imaging in diagnosis of adrenal adenoma. J Assoc Physicians India; 2006 Jan;54:34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemical shift imaging in diagnosis of adrenal adenoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Lipids / analysis. Magnetic Resonance Imaging. Male. Pheochromocytoma / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16649736.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Lipids
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7. Kim HY, Kim SG, Lee KW, Seo JA, Kim NH, Choi KM, Baik SH, Choi DS: Clinical study of adrenal incidentaloma in Korea. Korean J Intern Med; 2005 Dec;20(4):303-9
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  • [Title] Clinical study of adrenal incidentaloma in Korea.
  • BACKGROUND: This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas.
  • METHODS: Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively.
  • RESULTS: Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%).
  • Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%).
  • According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%).
  • During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome.
  • Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis.
  • CONCLUSIONS: These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Incidental Findings
  • [MeSH-minor] Adolescent. Adrenocortical Adenoma / diagnosis. Adult. Aged. Aged, 80 and over. Carcinoma / diagnosis. Female. Humans. Korea. Male. Middle Aged. Pheochromocytoma / diagnosis. Retrospective Studies

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  • (PMID = 16491828.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3891076
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8. Bembo SA, Elimian A, Waltzer W, Carlson HE: Pheochromocytoma in a pregnant woman with a history of intracerebral aneurysms. Am J Med Sci; 2005 Jun;329(6):317-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pheochromocytoma in a pregnant woman with a history of intracerebral aneurysms.
  • Pheochromocytoma in pregnancy is rare; if unrecognized, potentially fatal hypertensive crises may occur.
  • We report a case of a 35-year-old woman with a history of two intracerebral aneurysms who presented at 26 weeks' gestation with tachycardia, hypertension, and pulmonary edema.
  • Laboratory data revealed elevated 24-hour urinary catecholamine and metanephrine levels, and abdominal sonography showed a 10-cm right adrenal mass.
  • Postpartum abdominal computed tomography scanning confirmed a 10-cm right adrenal mass.
  • A benign pheochromocytoma was removed without incident.
  • This case illustrates the importance of early diagnosis and management of pheochromocytoma in pregnancy and is also an example of the rare association of pheochromocytoma with intracerebral aneurysms.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / diagnosis. Pregnancy Complications, Neoplastic / diagnosis


9. Koropatkin NM, Koppenaal DW, Pakrasi HB, Smith TJ: The structure of a cyanobacterial bicarbonate transport protein, CmpA. J Biol Chem; 2007 Jan 26;282(4):2606-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The structure of a cyanobacterial bicarbonate transport protein, CmpA.
  • To compensate for the low selectivity of Rubisco for CO2 over O2, cyanobacteria have developed highly efficient CO2-concentrating machinery of which the ABC transport system CmpABCD from Synechocystis PCC 6803 is one component.
  • Unexpectedly, bicarbonate binding is accompanied by a metal ion, identified as Ca2+ via inductively coupled plasma optical emission spectrometry.

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  • (PMID = 17121816.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Databank-accession-numbers] PDB/ 2I48/ 2I49/ 2I4B/ 2I4C
  • [Grant] United States / NIGMS NIH HHS / GM / GM078800
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATP-Binding Cassette Transporters; 0 / Bacterial Proteins; 0 / Bicarbonates
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10. Salamat A, Seaton J, Watson HG: Impact of introducing guidelines on anticoagulant reversal. Transfus Med; 2005 Apr;15(2):99-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Triggered by on going anecdotal evidence of poor practice, we reviewed the effect on practice of a recently introduced local guideline on the management of major bleeding in patients on warfarin.
  • Comparing 34 patients treated before and 48 patients after the introduction of the guideline, we found no significant improvement in prothrombin complex concentrate dosing or administration of vitamin K.
  • Of major concern, in 10% of cases, there was no documentation to confirm or refute that prothrombin complex concentrate (PCC), which had been issued, had actually been administered to the patient.

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  • (PMID = 15859975.001).
  • [ISSN] 0958-7578
  • [Journal-full-title] Transfusion medicine (Oxford, England)
  • [ISO-abbreviation] Transfus Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticoagulants
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11. Rondeau G, Nolet S, Latour M, Braschi S, Gaboury L, Lacroix A, Panzini B, Arjane P, Cohade C, Bourdeau I: Clinical and biochemical features of seven adult adrenal ganglioneuromas. J Clin Endocrinol Metab; 2010 Jul;95(7):3118-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and biochemical features of seven adult adrenal ganglioneuromas.
  • BACKGROUND: Adrenal ganglioneuroma (GN) is seldom considered in the differential diagnosis of adrenal lesions, and its clinical presentation is not well known.
  • OBJECTIVE: Our aim was to describe the clinical, biochemical, and radiological features of adrenal GNs in adults.
  • METHODS: Seven adults underwent endocrine investigation for adrenal lesions that were confirmed to be adrenal GNs.
  • Average tumor diameter was 5.0 cm (range, 1.5 to 10.4 cm).
  • In five patients, the adrenal lesions were found incidentally.
  • Bilateral adrenal venous sampling revealed testosterone production from her right adrenal lesion.
  • Three tumors were composite pheochromocytoma-GN.
  • Microsatellite instability study and immunohistochemical analysis of MSH2 protein in a patient carrying a MSH2 mutation showed normal MSH2 protein expression and low microsatellite instability, indicating that the adrenal GN was not related to the patient's MSH2 germline defect.
  • CONCLUSIONS: We describe one of the largest series of adult adrenal GNs.
  • Adrenal GNs may secrete testosterone or be part of a composite tumor with pheochromocytoma.
  • The association of adrenal GN with MSH2 mutation seems to be a coincidental finding.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Ganglioneuroma / pathology. Pheochromocytoma / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / metabolism. Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Incidental Findings. Magnetic Resonance Imaging. Male. Microsatellite Instability. Middle Aged. Neoplasm Proteins / metabolism. Nuclear Proteins / metabolism

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  • (PMID = 20427489.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins
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12. Singh AK, Sherman LA: Iron-independent dynamics of IsiA production during the transition to stationary phase in the cyanobacterium Synechocystis sp. PCC 6803. FEMS Microbiol Lett; 2006 Mar;256(1):159-64
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  • [Title] Iron-independent dynamics of IsiA production during the transition to stationary phase in the cyanobacterium Synechocystis sp. PCC 6803.
  • The de-repression of isiA during the stationary phase was neither dependent on iron nor a result of oxidative stress.

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  • (PMID = 16487334.001).
  • [ISSN] 0378-1097
  • [Journal-full-title] FEMS microbiology letters
  • [ISO-abbreviation] FEMS Microbiol. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Light-Harvesting Protein Complexes; 11016-15-2 / Phycocyanin; 1406-65-1 / Chlorophyll; 148266-13-1 / chlorophyll A binding protein CP43, Cyanobacteria; E1UOL152H7 / Iron
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13. Sadow PM, Rumilla KM, Erickson LA, Lloyd RV: Stathmin expression in pheochromocytomas, paragangliomas, and in other endocrine tumors. Endocr Pathol; 2008;19(2):97-103
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  • [Title] Stathmin expression in pheochromocytomas, paragangliomas, and in other endocrine tumors.
  • Pheochromocytomas are neuroendocrine tumors confined to the adrenal glands, and malignant pheochromocytomas can spread to various sites including the liver, lung, and bones.
  • Paragangliomas occur in numerous locations in the body, so assessment of metastatic disease is more challenging, as patients with familial syndromes often have multiple, possibly independent paragangliomas.
  • The most reliable criterion for malignancy in pheochromocytomas and paragangliomas is metastatic disease.
  • Because there are few immunohistochemical markers that are useful in the diagnosis of malignancy in pheochromocytomas and paragangliomas before they metastasize, more markers are needed to characterize these tumors.
  • We examined stathmin expression in tissues from patients with pheochromocytomas (n = 48), malignant pheochromocytomas (n = 28), paragangliomas (n = 42), and malignant paragangliomas (n = 21) by immunohistochemistry using tissue microarrays (TMA) with a polyclonal antibody against stathmin.
  • Stathmin was more highly expressed in pheochromocytomas compared to normal adrenals, a finding confirmed by Western blot.
  • There was higher expression of stathmin by immunohistochemical staining in malignant pheochromocytomas compared to pheochromocytomas without metastasis when analyzed by maximal staining (p = 0.012).
  • However, it is probably not useful as a stand-alone marker to determine malignancy in pheochromocytomas for individual tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Endocrine Gland Neoplasms / metabolism. Paraganglioma / metabolism. Pheochromocytoma / metabolism. Stathmin / biosynthesis
  • [MeSH-minor] Adult. Biomarkers, Tumor. Blotting, Western. Cell Proliferation. Female. Humans. Immunohistochemistry. Male. Middle Aged. Oligonucleotide Array Sequence Analysis

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  • (PMID = 18461287.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Stathmin
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14. Tiberio GA, Baiocchi GL, Arru L, Agabiti Rosei C, De Ponti S, Matheis A, Rizzoni D, Giulini SM: Prospective randomized comparison of laparoscopic versus open adrenalectomy for sporadic pheochromocytoma. Surg Endosc; 2008 Jun;22(6):1435-9
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  • [Title] Prospective randomized comparison of laparoscopic versus open adrenalectomy for sporadic pheochromocytoma.
  • BACKGROUND: Laparoscopic adrenalectomy for pheochromocytoma remains subject of debate, owing to the systemic consequences of pneumoperitoneum in patients with catecholamine-secreting tumors.
  • METHODS: A prospective randomized study was conducted (2000-2006), evaluating cardiovascular instability during open (n = 9, group A) or laparoscopic (n = 13, group B) adrenalectomy for pheochromocytoma.
  • CONCLUSIONS: Laparoscopic approach for pheochromocytoma can be as safe as open surgery; intraoperative haemodynamic instability, although usually controlled with success, remains a source of concern.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy / methods. Laparotomy / methods. Pheochromocytoma / surgery

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  • (PMID = 18398641.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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15. Holldack HJ: Induction of anesthesia triggers hypertensive crisis in a patient with undiagnosed pheochromocytoma: could rocuronium be to blame? J Cardiothorac Vasc Anesth; 2007 Dec;21(6):858-62
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  • [Title] Induction of anesthesia triggers hypertensive crisis in a patient with undiagnosed pheochromocytoma: could rocuronium be to blame?
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Anesthesia / adverse effects. Hypertension / etiology. Intraoperative Complications / etiology. Pheochromocytoma / complications
  • [MeSH-minor] Aged, 80 and over. Androstanols / adverse effects. Diagnosis, Differential. Female. Humans. Neuromuscular Nondepolarizing Agents / adverse effects


16. Chen YC, Su YC, Tzeng JE, Wei CK, Chiu JS, Lin CW, Wang YF: The Case | A woman with persistent chest pain and palpitations after coronary stenting. Bladder pheochromocytoma. Kidney Int; 2009 Jun;75(12):1361-2
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  • [Title] The Case | A woman with persistent chest pain and palpitations after coronary stenting. Bladder pheochromocytoma.
  • [MeSH-major] Pheochromocytoma / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Arrhythmias, Cardiac / etiology. Chest Pain / etiology. Coronary Artery Disease / therapy. Female. Humans. Stents. Urination


17. Srivastava R, Battchikova N, Norling B, Aro EM: Plasma membrane of Synechocystis PCC 6803: a heterogeneous distribution of membrane proteins. Arch Microbiol; 2006 Apr;185(3):238-43
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  • [Title] Plasma membrane of Synechocystis PCC 6803: a heterogeneous distribution of membrane proteins.
  • Proteomic studies carried out previously on the plasma membrane of Synechocystis have identified several peripheral and integral proteins.
  • In this study, the distribution of proteins along the plasma membrane of Synechocystis was carried out using subfractions, the right-side-out (RSO) and inside-out (ISO) vesicles, fractionated from a pure and specific fraction of the plasma membrane.
  • It was found that the ISO fraction contained higher quantities of preD1, D1 and PsaD, the integral proteins of photosystem I and II known to be present also in the plasma membrane.
  • Our studies clearly establish that the plasma membrane of Synechocystis has a heterogeneous composition with respect to protein distribution.
  • The accumulation of photosynthesis-associated proteins in the ISO fraction provides evidence that the discrete regions of the plasma membrane harbor sites for biogenesis of photosystems.

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  • (PMID = 16432747.001).
  • [ISSN] 0302-8933
  • [Journal-full-title] Archives of microbiology
  • [ISO-abbreviation] Arch. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Outer Membrane Proteins; 0 / Bacterial Proteins; 0 / Membrane Proteins; EC 3.4.21.4 / Trypsin
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18. Tozaki-Saitoh H, Koizumi S, Sato Y, Tsuda M, Nagao T, Inoue K: Retinoic acids increase P2X2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells. Mol Pharmacol; 2006 Jul;70(1):319-28
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  • [Title] Retinoic acids increase P2X2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells.
  • In rat pheochromocytoma PC-12 cells, treatment with 9-cis-retinoic acid as well as all-trans-retinoic acid significantly increased the mRNA and protein level of P2X2 receptor.
  • Furthermore, 9-cis-retinoic acid enhanced the ATP-evoked whole cell currents and intracellular Ca2+- and ATP-evoked dopamine release, indicating the up-regulation of functional P2X2 receptors on the plasma membrane.
  • [MeSH-minor] Adenosine Triphosphate / pharmacology. Animals. Base Sequence. Binding Sites / genetics. Blotting, Western. Calcium / metabolism. Dopamine / secretion. Gene Expression / drug effects. Luciferases / genetics. Luciferases / metabolism. Membrane Potentials / drug effects. Molecular Sequence Data. PC12 Cells. Pheochromocytoma / genetics. Pheochromocytoma / metabolism. Pheochromocytoma / pathology. Promoter Regions, Genetic / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rats. Receptors, Purinergic P2X2. Response Elements / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors / metabolism. Transfection

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  • (PMID = 16638968.001).
  • [ISSN] 0026-895X
  • [Journal-full-title] Molecular pharmacology
  • [ISO-abbreviation] Mol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / P2rx2 protein, rat; 0 / RNA, Messenger; 0 / Receptors, Purinergic P2; 0 / Receptors, Purinergic P2X2; 0 / Transcription Factors; 5300-03-8 / alitretinoin; 5688UTC01R / Tretinoin; 8L70Q75FXE / Adenosine Triphosphate; EC 1.13.12.- / Luciferases; SY7Q814VUP / Calcium; VTD58H1Z2X / Dopamine
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19. Gao B, Sun Y, Liu Z, Meng F, Shi B, Liu Y, Xu Z: A logistic regression model for predicting malignant pheochromocytomas. J Cancer Res Clin Oncol; 2008 Jun;134(6):631-4
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  • [Title] A logistic regression model for predicting malignant pheochromocytomas.
  • It is well known that no single histological feature is diagnostic for malignant pheochromocytomas (PCCs).
  • So we developed a logistic model based on a series of clinical and pathological features to predict malignance in PCCs, and evaluated its diagnostic performance.
  • In all 130 cases with malignant or benign PCCs, 15 predictive variables were observed and entered in the logistic regression analysis in a backward stepwise way.
  • High cellularity had the highest odds ratio (OR), followed by spindle cell (>10% of tumor volume), atypical mitotic figure, periadrenal adipose tissue invasion, mitotic figures [>3/10 high-power field (HPF)], cellular monotony, capsular invasion, vascular invasion, and central or confluent tumor necrosis.
  • High cellularity, spindle cell (>10% of tumor volume) and atypical mitotic figure were selected to built a logistic model.
  • The application of the model can benefit the clinical management decision for patients with PCCs.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / diagnosis

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  • (PMID = 17999082.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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20. Pérez-Pérez ME, Florencio FJ, Lindahl M: Selecting thioredoxins for disulphide proteomics: target proteomes of three thioredoxins from the cyanobacterium Synechocystis sp. PCC 6803. Proteomics; 2006 Apr;6 Suppl 1:S186-95
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  • [Title] Selecting thioredoxins for disulphide proteomics: target proteomes of three thioredoxins from the cyanobacterium Synechocystis sp. PCC 6803.
  • PCC 6803, using site-directed active-site cysteine-to-serine mutants of its m-, x- and y-type thioredoxins.
  • The properties of a thioredoxin that determine the outcome of such analyses were found to be target-binding capacity, solubility and the presence of non-active-site cysteines.
  • Thus, we explored how the choice of thioredoxin affects the target proteomes and we conclude that the m-type thioredoxin, TrxA, is by far the most useful for screening of disulphide proteomes.
  • Furthermore, we improved the resolution of target proteins on non-reducing/reducing 2-DE, leading to the identification of 14 new potentially redox-regulated proteins in this organism.

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  • (PMID = 16526092.001).
  • [ISSN] 1615-9861
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Disulfides; 0 / Proteome; 52500-60-4 / Thioredoxins
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21. Matsuda N, Uozumi N: Ktr-mediated potassium transport, a major pathway for potassium uptake, is coupled to a proton gradient across the membrane in Synechocystis sp. PCC 6803. Biosci Biotechnol Biochem; 2006 Jan;70(1):273-5
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  • [Title] Ktr-mediated potassium transport, a major pathway for potassium uptake, is coupled to a proton gradient across the membrane in Synechocystis sp. PCC 6803.
  • PCC 6803 contains a Ktr system and a putative ATP-dependent Kdp system for potassium uptake.

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  • (PMID = 16428848.001).
  • [ISSN] 0916-8451
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Cation Transport Proteins; 0 / Protons; RWP5GA015D / Potassium
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22. Subtel'na I, Atamanyuk D, Szymańska E, Kieć-Kononowicz K, Zimenkovsky B, Vasylenko O, Gzella A, Lesyk R: Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity. Bioorg Med Chem; 2010 Jul 15;18(14):5090-102
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  • All the target compounds were evaluated for the anticancer activity in vitro in standard National Cancer Institute 60 cancer cell lines assay.
  • Majority of compounds showed significant antitumor cytotoxicity effect at micromolar and submicromolar level (Mean LogGI50 ranges -5.77 to -4.35).
  • Some of the most potent compounds, namely 10 and 13, possessed selectively high effect on all leukemia cell lines at submicromolar level (Mean LogGI50 [leukemia lines], respectively, -6.41 and -6.29), which are probably associated with immunosuppressive activity.
  • Individual cancer cell lines sensitivity to synthesized compounds and SAR studies are discussed.
  • COMPARE analysis allowed to disclose probable modes of anticancer action for synthesized compounds, in particular showed number of high correlations with activity patterns of alkylating agents (PCC approximately 0.606-0.731).
  • [MeSH-minor] Cell Line, Tumor. Drug Screening Assays, Antitumor. Humans. Models, Molecular. Molecular Structure. Structure-Activity Relationship

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20594860.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Imidazoles
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23. Dashdorj N, Xu W, Cohen RO, Golbeck JH, Savikhin S: Asymmetric electron transfer in cyanobacterial Photosystem I: charge separation and secondary electron transfer dynamics of mutations near the primary electron acceptor A0. Biophys J; 2005 Feb;88(2):1238-49
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  • [Title] Asymmetric electron transfer in cyanobacterial Photosystem I: charge separation and secondary electron transfer dynamics of mutations near the primary electron acceptor A0.
  • Point mutations were introduced near the primary electron acceptor sites assigned to A0 in both the PsaA and PsaB branches of Photosystem I in the cyanobacterium Synechocystis sp. PCC 6803.
  • The dynamics of primary charge separation and secondary electron transfer were studied at 690 nm and 390 nm in these mutants by ultrafast optical pump-probe spectroscopy.
  • The data reveal that mutations in the PsaB branch do not alter electron transfer dynamics, whereas mutations in the PsaA branch have a distinct effect on electron transfer, slowing down both the primary charge separation and the secondary electron transfer step (the latter by a factor of 3-10).
  • [MeSH-major] Photosystem I Protein Complex / chemistry. Photosystem I Protein Complex / radiation effects

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  • (PMID = 15542554.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosystem I Protein Complex
  • [Other-IDs] NLM/ PMC1305126
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24. Tanaka A, Hamada N, Fujita Y, Itoh T, Nozawa Y, Iinuma M, Ito M: A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation. Bioorg Med Chem; 2010 May 1;18(9):3133-9
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  • In an attempt to identify kavalactone derivatives that are more potent in Nrf2/ARE activation than natural compounds, we synthesized a series of chemically-modified kavalactones and studied their effects on the ARE enhancer activity in rat pheochromocytoma PC12 cells.
  • Among 81 compounds tested, a kavalactone derivative, 2',6'-dichloro-5-methoxymethyl-5,6-dehydrokawain [(E)-6-(2',6'-dichlorostyryl)-4-methoxy-5-(methoxymethyl)-2H-pyran-2-one] (1), exhibited the strongest ARE enhancer activity.
  • The ARE activation and HO-1 protein induction by the compound 1 were higher than those by natural kavalactones.
  • The compound did not affect cell viability and induced expression of various phase II enzymes.
  • The compound transiently increased intracellular ROS levels.
  • Finally, pretreatment with the compound ameliorated H(2)O(2)-induced cell death, which was associated with increased expression of HO-1.
  • These results suggest that the compound 1 protects against oxidative stress-induced neuronal cell death via a preconditioning effect on the Nrf2/ARE activation.

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  • [Copyright] (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20371185.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2',6'-dichloro-5-methoxymethyl-5,6-dehydrokawain ((E)-6-(2',6'-dichlorostyryl)-4-methoxy-5-(methoxymethyl)-2H-pyran-2-one); 0 / Lactones; 0 / NF-E2-Related Factor 2; BBX060AN9V / Hydrogen Peroxide
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25. Lu X, Kambe F, Cao X, Kozaki Y, Kaji T, Ishii T, Seo H: 3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis. Endocrinology; 2008 Jul;149(7):3267-73
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  • Such antiapoptotic effects of DHCR24 were duplicated in pheochromocytoma PC12 cells infected with adenovirus.
  • Finally, using in vitro-synthesized and purified proteins, DHCR24 and its C-terminal deletion mutant were found to exhibit high H(2)O(2)-scavenging activity, whereas the N-terminal deletion mutant lost such activity.


26. Satpute RM, Hariharakrishnan J, Bhattacharya R: Alpha-ketoglutarate and N-acetyl cysteine protect PC12 cells from cyanide-induced cytotoxicity and altered energy metabolism. Neurotoxicology; 2008 Jan;29(1):170-8
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  • Rat pheochromocytoma (PC12) cells possess much of the biochemical machinery associated with synaptic neurons.
  • Data on leakage of intracellular lactate dehydrogenase and mitochondrial function (MTT assay) revealed that simultaneous treatment of A-KG (0.5 mM) and NAC (0.25 mM) significantly prevented the cytotoxicity of cyanide.
  • The study indicates that combined administration of A-KG and NAC protected the cyanide-challenged PC12 cells by resolving the altered energy metabolism.

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  • (PMID = 18078672.001).
  • [ISSN] 0161-813X
  • [Journal-full-title] Neurotoxicology
  • [ISO-abbreviation] Neurotoxicology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyanates; 0 / Free Radical Scavengers; 0 / Ketoglutaric Acids; 0 / Peroxides; 328-50-7 / alpha-ketoglutaric acid; 33X04XA5AT / Lactic Acid; G9C31TWN5M / potassium cyanate; SY7Q814VUP / Calcium; WYQ7N0BPYC / Acetylcysteine
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27. Yuyama K, Yamamoto N, Yanagisawa K: Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation. J Neurochem; 2008 Apr;105(1):217-24
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  • [Title] Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation.
  • We treated pheochromocytoma PC12 cells with chloroquine, an acidotropic agent, which potently perturbs membrane trafficking from endosomes to lysosomes.
  • Notably, amyloid-beta assembly was markedly accelerated when incubated with the exosome fraction prepared from the culture media of PC12 cells treated with chloroquine and KCl.
  • Furthermore, amyloid-beta assembly was significantly suppressed by the co-incubation with an antibody specific to GM1-bound amyloid-beta, an endogenous seed for amyloid formation of Alzheimer's disease.
  • Together with our previous finding that chloroquine treatment induces the accumulation of GM1 ganglioside in early endosomes, results of this study suggest that endocytic pathway abnormality accelerates the release of exosome-associated GM1 ganglioside following its accumulation in early endosomes.

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  • (PMID = 18021298.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amyloid beta-Peptides; 0 / Thiazoles; 2390-54-7 / thioflavin T; 37758-47-7 / G(M1) Ganglioside; 660YQ98I10 / Potassium Chloride; 886U3H6UFF / Chloroquine; SY7Q814VUP / Calcium
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28. Pohl PP, Meyer A, Lammers BJ, Goretzki PE: [Abdominal preoperation. No contraindication for laparoscopic transabdominal adrenalectomy]. Chirurg; 2008 Jun;79(6):571-5
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  • Benign adrenal gland tumors smaller than 6 cm are nowadays the indication for minimally invasive surgery.
  • [MeSH-major] Abdomen / surgery. Adrenal Gland Neoplasms / surgery. Adrenalectomy / contraindications. Adrenocortical Adenoma / surgery. Carcinoma / surgery. Cushing Syndrome / surgery. Laparoscopy / contraindications. Pheochromocytoma / surgery

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  • (PMID = 17879074.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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29. Fulda S, Mikkat S, Huang F, Huckauf J, Marin K, Norling B, Hagemann M: Proteome analysis of salt stress response in the cyanobacterium Synechocystis sp. strain PCC 6803. Proteomics; 2006 May;6(9):2733-45
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  • [Title] Proteome analysis of salt stress response in the cyanobacterium Synechocystis sp. strain PCC 6803.
  • In the present study, changes in protein synthesis patterns after salt shock visualized by 35S-methionine labeling and the changed protein composition in salt-acclimated cells of the cyanobacterium Synechocystis sp. strain PCC 6803 were analyzed by a combination of 2-DE for protein separation and PMF for protein identification.
  • The comparison of transcriptomic and proteomic analyses shows the significance of post-transcriptional regulatory mechanisms in acclimation of Synechocystis to high salt concentrations.

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  • (PMID = 16572470.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Proteome; 451W47IQ8X / Sodium Chloride
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30. Bae SJ, Kim DJ, Kim JY, Park SY, Choi SH, Song YD, Ki CS, Chung JH: A rare extracellular D631Y germline mutation of the RET proto-oncogene in two Korean families with multiple endocrine neoplasia 2A. Thyroid; 2006 Jun;16(6):609-14
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  • We report here on a rare extracellular mutation of the RET gene that led to the substitution of a tyrosine for an aspartate in codon 631 (D631Y, GAC to TAC) in two Korean families with MEN 2A.
  • Among them, medullary thyroid carcinoma (MTC) was identified in five patients: four of them had MEN 2A and one had familial MTC.
  • They had tumors 2 cm or less in the greatest dimension that were limited to the thyroid, and they had a relatively old age above 30 at the time of diagnosis.
  • Pheochromocytoma was detected in six patients including the four patients who had MEN 2A.
  • All had adrenal tumors greater than 3 cm in the greatest dimension, and four of them had bilateral tumors.
  • Two of six patients suffering with pheochromocytoma had no clinical evidence of MTC at the time of diagnosis.
  • This genetic profile might be related to the less vigorous clinical disease behavior and the late onset of MTC.
  • In addition, pheochromocytoma might be the first manifestation prior to the development of MTC in some patients with the D631Y mutation.
  • [MeSH-major] Carcinoma, Medullary / genetics. Germ-Line Mutation. Multiple Endocrine Neoplasia Type 2a / genetics. Proto-Oncogene Proteins c-ret / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adult. Base Sequence. Family Health. Female. Humans. Korea. Male. Middle Aged. Molecular Sequence Data. Pedigree. Pheochromocytoma / genetics

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  • (PMID = 16839264.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret
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31. Kansal A, Lahiri A, Nishikawa H: Sympathetic paraganglioma presenting with Horner's syndrome in a child. J Plast Reconstr Aesthet Surg; 2006;59(7):772-4
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  • [Title] Sympathetic paraganglioma presenting with Horner's syndrome in a child.
  • The majority of paragangliomas in the paediatric age groups have been familial, occurring in association with an adrenal pheochromocytoma.
  • Children typically present with a neck mass and systemic evidence of catecholamine hypersecretion.
  • We present the case of a 12-year-old boy with a history of increasing headache, drowsiness and Horner's syndrome for 8 months.
  • The histology showed that the mass was a well-circumscribed encapsulated tumour and that complete excision was achieved.
  • On review at 6 months following surgery, his scars were maturing satisfactorily but the Horner's syndrome was persistent.
  • Sympathetic chain paragangliomas are very rare tumours in the head and neck but should be considered in the differential diagnosis when clinical and radiographic evidence suggest a paraganglioma.
  • The presentation is typically of a slow-growing neck mass with the presence of an ipsilateral Horner's syndrome.
  • To our knowledge, this is the first reported case of a sympathetic chain paraganglioma in a child.
  • [MeSH-major] Autonomic Nervous System Diseases / complications. Head and Neck Neoplasms / complications. Horner Syndrome / complications. Paraganglioma / complications. Peripheral Nervous System Neoplasms / complications


32. Ambrosio A, Scaramuzzi M, Torlontano M, Di Sebastiano P: [Laparoscopic adrenalectomy: analysis of 65 cases]. Chir Ital; 2007 Nov-Dec;59(6):853-6
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  • On the basis of our analysis of the results we feel that we can safely claim, in agreement with the literature, that laparoscopic cholecystectomy is the treatment of choice for benign disease and that lesions measuring > 6 cm can be dealt with by surgical teams with good laparoscopic experience.
  • [MeSH-major] Adenoma / surgery. Adrenal Gland Neoplasms / surgery. Adrenal Hyperplasia, Congenital / surgery. Adrenalectomy. Hemangioma / surgery. Laparoscopy. Myelolipoma / surgery. Neurilemmoma / surgery. Pheochromocytoma / surgery
  • [MeSH-minor] Adolescent. Adrenal Gland Diseases / surgery. Adrenal Glands / pathology. Adult. Aged. Cysts / surgery. Female. Humans. Length of Stay. Male. Middle Aged. Postoperative Care. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18360991.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Italy
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33. Mirza MA: Anginalike pain and normal coronary arteries. Uncovering cardiac syndromes that mimic CAD. Postgrad Med; 2005 May;117(5):41-6, 54
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  • A detailed history and, in some cases, special diagnostic methods can help make the diagnosis.
  • When evaluating patients with anginalike chest pain and normal coronary arteries, physicians need to consider this group of diseases and tailor workup and diagnosis on an individual basis.
  • [MeSH-major] Chest Pain / etiology. Coronary Artery Disease / complications. Coronary Artery Disease / diagnosis
  • [MeSH-minor] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Amphetamine-Related Disorders / complications. Amphetamine-Related Disorders / diagnosis. Angina Pectoris, Variant / complications. Angina Pectoris, Variant / diagnosis. Aortic Valve Stenosis / complications. Aortic Valve Stenosis / diagnosis. Cocaine-Related Disorders / complications. Cocaine-Related Disorders / diagnosis. Diagnosis, Differential. Humans. Medical History Taking. Microvascular Angina / complications. Microvascular Angina / diagnosis. Mitral Valve Prolapse / complications. Mitral Valve Prolapse / diagnosis. Pheochromocytoma / complications. Pheochromocytoma / diagnosis. Prognosis. Risk Factors. Thyrotoxicosis / complications. Thyrotoxicosis / diagnosis


34. Estep JS, Baumgartner RE, Townsend F, Pabst DA, McLellan WA, Friedlaender A, Dunn DG, Lipscomb TP: Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus). Vet Pathol; 2005 May;42(3):357-9
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  • [Title] Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus).
  • Sertoli cell tumor and pheochromocytoma were also diagnosed in the spotted dolphin.
  • This is the first report of seminoma, Sertoli cell tumor, and pheochromocytoma in a dolphin, the first report of three distinct neoplasms in a dolphin, and one of the few reports of malignant neoplasia in dolphins.
  • [MeSH-major] Adrenal Gland Neoplasms / veterinary. Dolphins. Neoplasm Metastasis / pathology. Pheochromocytoma / veterinary. Seminoma / veterinary. Sertoli Cell Tumor / veterinary

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  • (PMID = 15872383.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Owecki M, Majewska KA, Stawny B, Nikisch E, Drews M, Sowiński J: [Adrenal tumours in a selected 10-years surgical material]. Pol Merkur Lekarski; 2006 Jun;20(120):678-81
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  • [Title] [Adrenal tumours in a selected 10-years surgical material].
  • [Transliterated title] Guzy nadnerczy w wybranym 10-letnim materiale operacyjnym.
  • The aim of the study was to analyze the number and proportions of different adrenal tumours resected during the last 10 years in our centre.
  • In 45 (65.22%) cases the right adrenal was affected, in 21 (30.43%)--the left, in 3 (4.35%)--both.
  • We observed no correlation between the age and preoperative tumor size (p = 0.1756), between the age and pathological tumor size (p = 0.3601), and between BMI and the preoperative and histopathologic size (p = 0.4204, and p = 0.6478, respectively).
  • CONCLUSIONS: The most common tumour was phaeochromocytoma.
  • Most tumours where found in the right adrenal.
  • No correlations between age and BMI, and tumour size where demonstrated.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17007266.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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36. Korpershoek E, Stobbe CK, van Nederveen FH, de Krijger RR, Dinjens WN: Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas. Endocr Relat Cancer; 2010 Sep;17(3):653-62
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  • [Title] Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas.
  • Pheochromocytomas (PCCs) and extra-adrenal sympathetic paragangliomas (sPGLs) are catecholamine-producing tumors occurring in the context of hereditary tumor syndromes, with known germline mutations, and as sporadic tumors.
  • The pathogenesis of sporadic PCC and sPGL is poorly understood, and little is known about intra-tumoral heterogeneity with respect to molecular aberrations.
  • Since knowledge on intra-tumoral heterogeneity is important for understanding the pathogenesis of these tumors, we investigated 12 benign and 8 malignant PCCs and sPGLs for loss of heterozygosity (LOH) on DNA extracted from different regions of each tumor and from metastases.
  • LOH markers were selected on chromosomal regions frequently deleted in PCC, including 1p, 3q, 3p, and 11p.
  • In addition, differences in LOH patterns were detected between paired primary malignant tumors, and their metastases and different LOH patterns were observed in bilateral PCC of a multiple endocrine neoplasia type 2 patient.
  • We demonstrate that malignant PCC and sPGL have more intra-tumoral molecular heterogeneity than benign tumors, which suggests that benign and malignant PCC and sPGL have a different pathogenesis.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Chromosomes, Human. Loss of Heterozygosity. Paraganglioma / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. DNA, Neoplasm / genetics. Female. Genetic Variation. Histocytochemistry. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 20488782.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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37. Haftgoli N, Favrat B, Verdon F, Vaucher P, Bischoff T, Burnand B, Herzig L: Patients presenting with somatic complaints in general practice: depression, anxiety and somatoform disorders are frequent and associated with psychosocial stressors. BMC Fam Pract; 2010;11:67
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  • BACKGROUND: Mental disorders in primary care patients are frequently associated with physical complaints that can mask the disorder.
  • Our primary objective was to determine the prevalence of depression, anxiety, and somatoform disorders among primary care patients with a physical complaint.
  • METHODS: We conducted a multicentre cross-sectional study in twenty-one private practices and in one academic primary care centre in Western Switzerland.
  • The validated French version of the PHQ allowed the diagnosis of mental disorders (DSM-IV criteria) and the analyses of exposure to psychosocial stressors.
  • CONCLUSIONS: The investigation of mental disorders and psychosocial stressors among patients with physical complaints is relevant in primary care.
  • [MeSH-minor] Cross-Sectional Studies. Female. Humans. Male. Middle Aged. Prevalence. Primary Health Care. Surveys and Questionnaires. Switzerland / epidemiology


38. Chrispal A, Begum A, Ramya I, Zachariah A: Hair dye poisoning--an emerging problem in the tropics: an experience from a tertiary care hospital in South India. Trop Doct; 2010 Apr;40(2):100-3
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  • [Title] Hair dye poisoning--an emerging problem in the tropics: an experience from a tertiary care hospital in South India.
  • A retrospective study was conducted over 3.5 years (January 2006-July 2009) of 13 consecutive patients with Super-Vasmol poisoning admitted to a tertiary care, referral hospital in South India.
  • Trends towards a poor outcome were evident among the following patients: late presentation at our centre; when no gastric lavage was done at the primary-care centre; those requiring tracheostomy/intubation at the primary centre; presentation with a low Glasgow Coma Score or seizures; established renal failure; and those who subsequently require dialysis, mechanical ventilation or intensive care.
  • [MeSH-minor] Adult. Female. Hospitals, Teaching / statistics & numerical data. Humans. India / epidemiology. Length of Stay. Poisoning / diagnosis. Poisoning / mortality. Poisoning / therapy. Retrospective Studies. Socioeconomic Factors. Time Factors. Treatment Outcome

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  • (PMID = 20305106.001).
  • [ISSN] 1758-1133
  • [Journal-full-title] Tropical doctor
  • [ISO-abbreviation] Trop Doct
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hair Dyes; 0 / Phenylenediamines
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39. Soler-González J, Serna MC, Bosch A, Ruiz MC, Huertas E, Rué M: Sick leave among native and immigrant workers in Spain--a 6-month follow-up study. Scand J Work Environ Health; 2008 Dec;34(6):438-43
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  • METHODS: This observational follow-up study included 1427 immigrants and 2793 Spanish natives treated at five primary care centers in Lleida in 2005 and followed for 6 months.
  • [MeSH-minor] Absenteeism. Adolescent. Adult. Africa South of the Sahara / ethnology. Continental Population Groups / statistics & numerical data. Europe, Eastern / ethnology. Female. Follow-Up Studies. Humans. Job Satisfaction. Latin America / ethnology. Male. Middle Aged. Primary Health Care. Regression Analysis. Sex Distribution. Spain. Young Adult

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  • (PMID = 19137205.001).
  • [ISSN] 0355-3140
  • [Journal-full-title] Scandinavian journal of work, environment & health
  • [ISO-abbreviation] Scand J Work Environ Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Finland
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40. Hirota K, Kushikata T, Yoshida H, Kudo M, Kudo T: Role of the orexinergic system in acute haemorrhage in the rat. Neurosci Lett; 2008 Feb 20;432(2):162-6
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  • In addition, plasma orexin A and catecholamine concentrations in the shed blood were determined.
  • Plasma catecholamine concentrations significantly increased following blood withdrawal.
  • The reduction in MAP/HR and elevation of catecholamine levels were dependent on the total amount of shed blood.
  • Plasma OXA concentrations increased to a greater extent in group SB than group S in response to haemorrhage.
  • There was a significant correlation between plasma catecholamines and %change in MAP (epinephrine: r=0.553, p=0.0001, norepinephrine: r=0.374, p=0.0087) and HR (epinephrine: r=0.403, p=0.005, norepinephrine: r=0.436, p=0.002).
  • There was no correlation with plasma orexin A levels.

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  • (PMID = 18187260.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea; 0 / Benzoxazoles; 0 / Catecholamines; 0 / Intracellular Signaling Peptides and Proteins; 0 / Neuropeptides; 0 / Orexin Receptors; 0 / Orexins; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Neuropeptide; 8W8T17847W / Urea
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41. Jackson M, Ashley D: Physical and psychological violence in Jamaica's health sector. Rev Panam Salud Publica; 2005 Aug;18(2):114-21
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  • Sampling was done at public facilities, including specialist, tertiary, and secondary hospitals in the Kingston Metropolitan Area; general hospitals in the rural parishes; and primary care centers in urban and rural areas.
  • Sampling was also done in private hospitals and private medical centers.
  • [MeSH-major] Health Care Sector. Occupational Exposure. Violence / psychology. Violence / statistics & numerical data

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  • (PMID = 16156962.001).
  • [ISSN] 1020-4989
  • [Journal-full-title] Revista panamericana de salud pública = Pan American journal of public health
  • [ISO-abbreviation] Rev. Panam. Salud Publica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Nonaka D, Chiriboga L, Rubin BP: Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol; 2008 Sep;32(9):1291-8
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  • Despite its low specificity, S100 protein is valuable for the diagnosis of desmoplastic melanomas and peripheral nerve sheath tumors, for which no specific marker is available.
  • Sox10 reaction was seen only in sustentacular cells of pheochromocytomas/paragangliomas, and occasionally carcinoid tumors from various organs, but it was not seen in the tumor cells.
  • Our results indicate that Sox10 will serve as a more sensitive and specific marker for the diagnosis of melanocytic and schwannian tumors than S100 protein.
  • [MeSH-major] Biomarkers, Tumor / analysis. DNA-Binding Proteins / biosynthesis. High Mobility Group Proteins / biosynthesis. Melanocytes / metabolism. Schwann Cells / metabolism. Transcription Factors / biosynthesis
  • [MeSH-minor] Humans. Immunohistochemistry. Melanoma / diagnosis. Nerve Sheath Neoplasms / diagnosis. S100 Proteins / metabolism. SOXE Transcription Factors. Sensitivity and Specificity. Skin Neoplasms / diagnosis. Tissue Array Analysis

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  • (PMID = 18636017.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / High Mobility Group Proteins; 0 / S100 Proteins; 0 / SOX10 protein, human; 0 / SOXE Transcription Factors; 0 / Transcription Factors
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43. Ilias I, Torpy DJ, Pacak K, Mullen N, Wesley RA, Nieman LK: Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health. J Clin Endocrinol Metab; 2005 Aug;90(8):4955-62
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  • [Title] Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health.
  • SETTING: The study was performed at a tertiary care clinical research center.
  • Surgery confirmed an ACTH-secreting tumor in 59 of 66 patients and cured 65%.
  • Deaths included three of 35 with pulmonary carcinoid, two of five with thymic carcinoid, four of six with gastrinoma, two of 13 with neuroendocrine tumor, two of two with medullary thyroid cancer, one of five with pheochromocytoma, three of three with small-cell lung cancer, and two of 17 with occult tumor.
  • Although only 47% achieved cure, survival is good except in patients with small-cell lung cancer, medullary thyroid cancer, and gastrinoma.
  • [MeSH-major] Carcinoid Tumor / complications. Cushing Syndrome / diagnosis. Cushing Syndrome / therapy. Lung Neoplasms / complications


44. Agarwal A, Mehrotra PK, Jain M, Gupta SK, Mishra A, Chand G, Agarwal G, Verma AK, Mishra SK, Singh U: Size of the tumor and pheochromocytoma of the adrenal gland scaled score (PASS): can they predict malignancy? World J Surg; 2010 Dec;34(12):3022-8
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  • [Title] Size of the tumor and pheochromocytoma of the adrenal gland scaled score (PASS): can they predict malignancy?
  • BACKGROUND: Size can predict malignancy in adrenocortical tumors, but the same extrapolation for pheochromocytomas (PCC) is controversial.
  • The goal of this study was to find a correlation between the tumor size and malignant potential of PCC and determine whether the "Pheochromocytoma of the adrenal gland scaled score" (PASS) proposed by Thompson can be applied to predict malignancy.
  • METHODS: A retrospective analysis of patients with PCC operated on from 1991 to 2007 revealed 98 PCC removed from 93 patients.
  • Tumor size was available for 90 tumors.
  • Of the sporadic benign cases, 21 (41%) patients with tumor size > 6 cm had a PASS of >4, and none of them developed metastasis.
  • PASS ≤ 4 was found in 25 (81%) PCC in the ≤6-cm group, and none developed metastases.
  • No correlation was found between tumor size and PASS > 4 and PASS ≤ 4 (7.8 cm vs. 7.1 cm; p = 0.23).
  • CONCLUSIONS: Presently there is not enough evidence to indict a large (>6 cm) PCC as malignant.
  • Furthermore, PASS cannot be reliably applied to PCC for predicting malignancy.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Neoplasm Staging. Pheochromocytoma / pathology

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  • (PMID = 20703467.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
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  • [Publication-type] Journal Article
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45. Ceballos-Chávez M, Vioque A: Sequence-dependent cleavage site selection by RNase Z from the cyanobacterium Synechocystis sp. PCC 6803. J Biol Chem; 2005 Sep 30;280(39):33461-9
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  • [Title] Sequence-dependent cleavage site selection by RNase Z from the cyanobacterium Synechocystis sp. PCC 6803.
  • We have identified and cloned the gene coding for RNase Z in the cyanobacterium Synechocystis sp. PCC 6803.
  • The presence of C or CC after the discriminator nucleotide modifies the cleavage site of RNase Z so that it is displaced by one and two nucleotides to the 3'-side, respectively.
  • The properties of the enzyme described here could be related with the mechanism by which CCA is added in this organism, with the participation of two separate nucleotidyl transferases, one specific for the addition of C and another for the addition of A.

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  • (PMID = 16051605.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA Precursors; 0 / Recombinant Proteins; 9014-25-9 / RNA, Transfer; EC 3.1.- / Endoribonucleases; EC 3.1.- / RNase Z; EC 3.1.4.- / Phosphoric Diester Hydrolases
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46. Osanai T, Imashimizu M, Seki A, Sato S, Tabata S, Imamura S, Asayama M, Ikeuchi M, Tanaka K: ChlH, the H subunit of the Mg-chelatase, is an anti-sigma factor for SigE in Synechocystis sp. PCC 6803. Proc Natl Acad Sci U S A; 2009 Apr 21;106(16):6860-5
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  • [Title] ChlH, the H subunit of the Mg-chelatase, is an anti-sigma factor for SigE in Synechocystis sp. PCC 6803.
  • PCC 6803, a positive regulator of sugar catabolism, is posttranslationally activated by light-to-dark transition.

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  • (PMID = 19342483.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Protein Subunits; 0 / Recombinant Fusion Proteins; 0 / Repressor Proteins; 0 / Sigma Factor; 0 / sigE protein, Bacteria; EC 2.7.7.6 / DNA-Directed RNA Polymerases; EC 4.- / Lyases; EC 4.99.1- / magnesium chelatase; EC 4.99.1.- / ChlH protein, Synechocystis; I38ZP9992A / Magnesium
  • [Other-IDs] NLM/ PMC2672518
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47. Federlin M, Krifka S, Herpich M, Hiller KA, Schmalz G: Partial ceramic crowns: influence of ceramic thickness, preparation design and luting material on fracture resistance and marginal integrity in vitro. Oper Dent; 2007 May-Jun;32(3):251-60
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  • This in vitro study tested the effects of two different ceramic thicknesses, two preparation designs and two different luting agents on the marginal integrity and fracture resistance of partial ceramic crowns (PCC).
  • PCC (Vita Mark II, Cerec3 System) were fabricated and the ceramic thickness of the functional cusps was adjusted to (1): 0.5-1.0 mm and (2): 1.5-2.0 mm.
  • PCC were adhesively luted to the cavities with either Excite/VariolinkII (VL) or RelyX Unicem (RX).
  • Fifteen PCC of group 1 (0.5-1.0 mm) and two PCC of group 2 (1.5-2.0 mm) were fractured after thermocycling and central mechanical loading, with the difference being statistically significant.
  • PCC fabricated from industrially sintered feldspathic ceramic should have at least a thickness of 1.5-2.0 mm in stress-bearing areas.

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  • (PMID = 17555176.001).
  • [ISSN] 0361-7734
  • [Journal-full-title] Operative dentistry
  • [ISO-abbreviation] Oper Dent
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Rely X Unicem; 0 / Resin Cements; 12001-21-7 / Dental Porcelain; 179240-22-3 / Variolink
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48. Jajoo S, Mukherjea D, Brewer GJ, Ramkumar V: Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. Neuroscience; 2008 Jan 24;151(2):525-32
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  • In this study, we show that Tat-mediated intracellular Ca(2+) release in rat pheochromocytoma (PC-12) cells and rat primary cortical neuronal cultures was abrogated by pretreatment with either pertussis toxin and/or its B-oligomer subunit (PTX-B), devoid of ADP ribosyltransferase activity.
  • Activation of protein kinase C (PKC) by phorbol 12,13-dibutyrate (PdBu) mimicked the PTX-B-mediated inhibition of m-3M3FBS-stimulated intracellular Ca(2+) increase, while inhibition of PKC by bisindolylmaleimide I hydrochloride (BIM) reversed the inhibitory action of PTX-B.
  • We conclude that PTX inhibition of Tat-mediated intracellular Ca(2+) release is independent of ADP ribosylation of the G(i) protein via the A protomer, but mediated by the B-oligomer.

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  • (PMID = 18093742.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / tat Gene Products, Human Immunodeficiency Virus; 20762-30-5 / Adenosine Diphosphate Ribose; EC 2.4.2.31 / Pertussis Toxin; EC 2.7.11.13 / Protein Kinase C; EC 3.1.4.11 / Phospholipase C beta; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; SY7Q814VUP / Calcium
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49. Cheng B, Yang X, Hou Z, Lin X, Meng H, Li Z, Liu S: D-beta-hydroxybutyrate inhibits the apoptosis of PC12 cells induced by 6-OHDA in relation to up-regulating the ratio of Bcl-2/Bax mRNA. Auton Neurosci; 2007 Jul 31;134(1-2):38-44
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  • It has been reported that ketone bodies could protect dopaminergic culture.
  • However, the biological function of DbetaHB in Parkinson disease (PD) is still unclear.
  • In the present work, we investigated the role of DbetaHB in protecting rat pheochromocytoma (PC12) cells from apoptosis induced by 6-Hydroxydopamine (6-OHDA).

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  • (PMID = 17369104.001).
  • [ISSN] 1566-0702
  • [Journal-full-title] Autonomic neuroscience : basic & clinical
  • [ISO-abbreviation] Auton Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bax protein, rat; 0 / RNA, Messenger; 0 / Sympatholytics; 0 / bcl-2-Associated X Protein; 8HW4YBZ748 / Oxidopamine; EC 3.4.22.- / Caspase 3; TZP1275679 / 3-Hydroxybutyric Acid
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50. Karasek D, Frysak Z, Pacak K: Genetic testing for pheochromocytoma. Curr Hypertens Rep; 2010 Dec;12(6):456-64
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  • [Title] Genetic testing for pheochromocytoma.
  • Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are rare, catecholamine-producing tumors that are usually sporadic.
  • Identification of a gene mutation may lead to early diagnosis and treatment, regular surveillance, and a better prognosis for patients and their relatives.
  • [MeSH-major] Adrenal Gland Neoplasms. Genetic Testing. Multiple Endocrine Neoplasia Type 2a. Pheochromocytoma

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  • (PMID = 20938758.001).
  • [ISSN] 1534-3111
  • [Journal-full-title] Current hypertension reports
  • [ISO-abbreviation] Curr. Hypertens. Rep.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HD008735-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catecholamines; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Other-IDs] NLM/ NIHMS230052; NLM/ PMC3061287
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51. Gursoy A, Erdogan MF: Severe pulmonary involvement and pheochromocytoma in atypical patient with neurofibromatosis type 1. Endocr Pract; 2006 Jul-Aug;12(4):469-71
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  • [Title] Severe pulmonary involvement and pheochromocytoma in atypical patient with neurofibromatosis type 1.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Lung Diseases / etiology. Neurofibromatosis 1 / complications. Pheochromocytoma / complications


52. Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A, Vincitore M, Michelini A, Fuchs CS: Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol; 2006 Jan 20;24(3):401-6
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  • We evaluated the efficacy of an oral regimen of temozolomide and thalidomide in patients with metastatic carcinoid, pheochromocytoma, or pancreatic neuroendocrine tumors.
  • RESULTS: Treatment with temozolomide and thalidomide was associated with an objective biochemical (chromogranin A) response rate of 40%, and a radiologic response rate of 25% (45% among pancreatic endocrine tumors, 33% among pheochromocytomas, and 7% among carcinoid tumors).
  • [MeSH-major] Adrenal Gland Neoplasms / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoid Tumor / drug therapy. Pancreatic Neoplasms / drug therapy. Pheochromocytoma / drug therapy
  • [MeSH-minor] Adult. Aged. Angiogenesis Inhibitors / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Carcinoma, Islet Cell / drug therapy. Dacarbazine / administration & dosage. Dacarbazine / analogs & derivatives. Disease-Free Survival. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neuroendocrine Tumors / drug therapy. Survival Analysis. Thalidomide / administration & dosage. Treatment Outcome

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  • (PMID = 16421420.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K23 CA 093401; United States / NHLBI NIH HHS / HL / K30 HL04095
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents, Alkylating; 4Z8R6ORS6L / Thalidomide; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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53. Erlic Z, Neumann HP: Familial pheochromocytoma. Hormones (Athens); 2009 Jan-Mar;8(1):29-38
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  • [Title] Familial pheochromocytoma.
  • Pheochromocytomas and Paragangliomas (PGL) form the group of paraganglial tumours which can occur in any paraganglia from the skull base to the pelvic floor.
  • While the World Health Organization (WHO) applies pheochromocytoma exclusively to adrenal tumours, many clinicians use the term pheochromocytoma also for extra-adrenal abdominal and thoracic tumours, since by tradition pheochromocytoma is a vasoactive tumour.
  • In contrast, head and neck paraganglioma is mostly only a space-occupying mass.
  • The diagnosis is confirmed by both biochemical testing and radiological imaging.
  • One third of patients with pheochromocytomas and paragangliomas are carriers of germline mutations in one of 6 genes and thus have a hereditary disorder.
  • About 1% of Neurofibromatosis (NF) 1 patients have pheochromocytomas.
  • All pheochromocytoma patients with NF 1 also show cutaneous lesions.
  • About 50% of MEN2 patients harbour pheochromocytoma.
  • The dominant lesion in this entity is Medullary Thyroid Carcinoma (MTC) occurring in up to 100% of patients.
  • Von Hippel-Lindau disease (VHL)is found in about 20% of patients in association with pheochromocytoma.
  • VHL is classified as type 1 predominantly without and type 2 predominantly with pheochromocytoma.
  • Paraganglioma syndromes include predisposition to paraganglial tumours in any location, whereas PGL 3 patients mostly show only head and neck paragangliomas.
  • Familial paraganglial tumours are characterized by younger age at diagnosis and more frequently multifocal and extra-adrenal abdominal pheochromocytomas.
  • Patients with PGL 4 and less frequently VHL, are particularly predisposed to malignant pheochromocytoma.
  • Endoscopic surgery is the primary treatment for pheochromocytoma.
  • No specific treatment has been proposed for prevention of the disease in inherited disorders.
  • Thus, early diagnosis and regular follow-up are the only means for a better outcome.
  • [MeSH-major] Paraganglioma / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / genetics. Carcinoma, Medullary / genetics. Humans. Multiple Endocrine Neoplasia Type 2a / genetics. Neurofibromatosis 1 / genetics. Succinate Dehydrogenase / genetics. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / genetics. von Hippel-Lindau Disease / genetics

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  • (PMID = 19269919.001).
  • [ISSN] 1109-3099
  • [Journal-full-title] Hormones (Athens, Greece)
  • [ISO-abbreviation] Hormones (Athens)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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54. Sanchez-Recalde A, Costero O, Oliver JM, Iborra C, Ruiz E, Sobrino JA: Images in cardiovascular medicine. Pheochromocytoma-related cardiomyopathy: inverted Takotsubo contractile pattern. Circulation; 2006 May 2;113(17):e738-9
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  • [Title] Images in cardiovascular medicine. Pheochromocytoma-related cardiomyopathy: inverted Takotsubo contractile pattern.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Cardiomyopathies / etiology. Myocardial Contraction. Pheochromocytoma / complications


55. Araújo LG, Lima DM, Sampaio RF, Pereira LS: Pain Locus of control scale: adaption and reliability for elderly. Rev Bras Fisioter; 2010 Sep-Oct;14(5):438-45
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  • The pain locus of control has become essential to understand how the perceptions, expectations and beliefs are related to individual behavior, attitudes, coping and adherence of the elderly with regards to the health conditions and with the proposed treatment.
  • Pearson's correlation coefficient (PCC) and the intraclass correlation coefficient (ICC) were used for the statistical analysis (p<0.05).
  • The average pain duration was 10.2 years and the main clinical diagnosis was osteoarthritis.
  • The reliability of the scale was adequate, with a regular to very strong correlations (PCC = 0.60 to 0.93) and a moderate to nearly perfect ICC (0.60 to 0.93), in mainly the chance locus of control and medical and healthcare professionals locus of control subscales.

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  • (PMID = 21180870.001).
  • [Journal-full-title] Revista brasileira de fisioterapia (São Carlos (São Paulo, Brazil))
  • [ISO-abbreviation] Rev Bras Fisioter
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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56. Lee JH, Campbell KH: Effects of enucleation and caffeine on maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) activities in ovine oocytes used as recipient cytoplasts for nuclear transfer. Biol Reprod; 2006 Apr;74(4):691-8
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  • MII oocytes contain high levels of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK), which cause nuclear envelope breakdown (NEBD) and premature chromosome condensation (PCC) in the transferred nucleus and have been implicated in nuclear reprogramming.
  • However, the occurrence of NEBD and the extent of PCC are variable between individual oocytes and species and are dependent on donor cell type and cell cycle stage.

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  • (PMID = 16371593.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 3G6A5W338E / Caffeine; EC 2.7.11.22 / Maturation-Promoting Factor; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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57. Schimke RN, Collins DL, Stolle CA: Paraganglioma, neuroblastoma, and a SDHB mutation: Resolution of a 30-year-old mystery. Am J Med Genet A; 2010 Jun;152A(6):1531-5
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  • [Title] Paraganglioma, neuroblastoma, and a SDHB mutation: Resolution of a 30-year-old mystery.
  • Familial paraganglioma/pheochromocytoma (PGL/PCC) is genetically heterogenous with mutations in three of the four subunits of the heterotetrameric mitochondrial complex II enzyme succinate dehydrogenase (SDH) being causally responsible for the majority of cases.
  • In addition to PGL/PCC an array of non-paraganglial tumors have been described in affected individuals.
  • We present a 30-year follow-up on the family of a deceased patient who synchronously developed malignant neuroblastoma (NBL), PCC, and renal cell carcinoma (RCC).
  • Other family members with late onset disease have come to our attention, and molecular study revealed a mutation in the SDHB gene.
  • Despite the embryologic relationship, NBL has been seen in only two previous patients with familial PGL/PCC, both with deletions of the SDHB gene.
  • Review of the literature suggests the lack of a reported association between NBL and familial PGL/PCC may be an ascertainment bias.
  • We further suggest that study of the SDH genes in NBL survivors who develop secondary solid tumors, particularly RCC, may correct this bias, and provide for more effective and comprehensive tumor screening in this patient population.
  • [MeSH-major] Neuroblastoma / genetics. Paraganglioma / genetics. Succinate Dehydrogenase / genetics
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / genetics. Female. Humans. Kidney Neoplasms / genetics. Male. Middle Aged. Mutation. Neoplasms, Second Primary / genetics. Young Adult

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20503330.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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58. Höckelmann C, Becher PG, von Reuss SH, Jüttner F: Sesquiterpenes of the geosmin-producing cyanobacterium Calothrix PCC 7507 and their toxicity to invertebrates. Z Naturforsch C; 2009 Jan-Feb;64(1-2):49-55
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  • [Title] Sesquiterpenes of the geosmin-producing cyanobacterium Calothrix PCC 7507 and their toxicity to invertebrates.
  • The occurrence of sesquiterpenes was investigated with the geosmin-producing cyanobacterium Calothrix PCC 7507.
  • The essential oil obtained by vacuum destillation was studied in more detail by GC-MS methods and superposition with authentic compounds.
  • Geosmin was the dominating compound while the other sesquiterpenes were minor components.
  • Closed-loop stripping analysis revealed that most of the sesquiterpenes were found in the biomass of Calothrix, while eremophilone was mainly observed in the medium of the axenic culture.
  • The compound was not toxic for Plectus cirratus (nematoda).
  • 6,11-Epoxyisodaucane and isodihydroagarofuran exhibited no toxicity to invertebrates when applied in concentrations up to 100 microM.

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  • (PMID = 19323266.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Insecticides; 0 / Naphthols; 0 / Sesquiterpenes; MYW912WXJ4 / geosmin
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59. Ukrainczyk M, Kontrec J, Kralj D: Precipitation of different calcite crystal morphologies in the presence of sodium stearate. J Colloid Interface Sci; 2009 Jan 1;329(1):89-96
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  • The influence of sodium stearate (NaSt) on the precipitation of calcium carbonate during the semicontinuous process of slaked lime carbonation was studied in the systems in which process parameters, like concentration of total dissolved calcium, temperature, CO(2) flow rate and initial addition rate of slaked lime, were controlled.
  • It was found that calcite was the only calcium carbonate polymorph that appeared under the investigated experimental conditions, while FT-IR spectroscopy and thermogravimetric analysis of samples confirmed the presence of stearate on the surface of precipitated calcium carbonate (PCC).
  • Specific surface area of PCC increased with increasing stearate content: the highest value, s = 52.8 m(2) g(-1), was obtained at t = 20 degrees C, c(tot) = 17.0 mmol dm(-3) and the stearate content of m(NaSt)/m(CaO) = 0.03.
  • The exception is the case of nanosized PCC production, when much higher concentration of NaSt is needed, m(NaSt)/m(CaO) = 0.22.

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  • (PMID = 18848702.001).
  • [ISSN] 1095-7103
  • [Journal-full-title] Journal of colloid and interface science
  • [ISO-abbreviation] J Colloid Interface Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Laurent M, Daline T, Malika B, Fawzi O, Philippe V, Benoit D, Catherine M, Jacques R: Training-induced increase in nitric oxide metabolites in chronic heart failure and coronary artery disease: an extra benefit of water-based exercises? Eur J Cardiovasc Prev Rehabil; 2009 Apr;16(2):215-21
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  • [Title] Training-induced increase in nitric oxide metabolites in chronic heart failure and coronary artery disease: an extra benefit of water-based exercises?
  • DESIGN: This study investigated whether a rehabilitation program including water-based exercises has additional effects on the cardiovascular system compared with a traditional land-based training in heart disease patients.
  • METHODS: Twenty-four male stable chronic heart failure patients and 24 male coronary artery disease patients with preserved left ventricular function participated in the study.
  • Resting plasma concentration of nitric oxide metabolites (nitrate and nitrite) and catecholamine were evaluated, and a symptom-limited exercise test on a cycle ergometer was performed before and after the rehabilitation program.
  • RESULTS: In the groups performing water-based exercises, the plasma concentration of nitrates was significantly increased (P = 0.035 for chronic heart failure and P = 0.042 for coronary artery disease), whereas it did not significantly change in the groups performing gymnastic exercise on land.
  • No changes in plasma catecholamine concentration occurred.
  • The water-based exercises seemed to effectively increase the basal level of plasma nitrates.
  • [MeSH-major] Bicycling. Coronary Artery Disease / rehabilitation. Exercise Therapy / methods. Gymnastics. Heart Failure / rehabilitation. Immersion. Nitric Oxide / blood
  • [MeSH-minor] Biomarkers / blood. Catecholamines / blood. Chronic Disease. Exercise Tolerance. Humans. Male. Middle Aged. Natriuretic Peptide, Brain / blood. Nitrates / blood. Nitrites / blood. Peptide Fragments / blood. Swimming Pools. Treatment Outcome. Up-Regulation. Ventricular Function, Left

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  • (PMID = 19276981.001).
  • [ISSN] 1741-8275
  • [Journal-full-title] European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
  • [ISO-abbreviation] Eur J Cardiovasc Prev Rehabil
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Catecholamines; 0 / Nitrates; 0 / Nitrites; 0 / Peptide Fragments; 0 / pro-brain natriuretic peptide (1-76); 114471-18-0 / Natriuretic Peptide, Brain; 31C4KY9ESH / Nitric Oxide
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61. Segura J, Roldán C, Galera J, Naval J: What Do Spanish physicians believe and expect about telemedicine? Results of a Delphi-based survey. Telemed J E Health; 2008 Jan-Feb;14(1):42-8
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  • [Title] What Do Spanish physicians believe and expect about telemedicine? Results of a Delphi-based survey.
  • The participants were 65% males, with a mean age of 46.7 years old and 20.3 years in the profession, mostly coming from primary care centers (91.8%) of urban Spanish areas (72.8%).
  • Most Spanish physicians have not implemented telemedicine in clinical practice, but they would be interested in future applications such as on-line training or disease control, although they still prefer physical patient contact.

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  • (PMID = 18328024.001).
  • [ISSN] 1530-5627
  • [Journal-full-title] Telemedicine journal and e-health : the official journal of the American Telemedicine Association
  • [ISO-abbreviation] Telemed J E Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Molina París J, Lumbreras García G, Calvo Corbella E, Naberan Toña K, Lobo Alvarez MA: [Cost and management of asthma attacks treated in primary care (COAX Study)]. Aten Primaria; 2005 Jun 15;36(1):6-11; discussion 12-3
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  • [Title] [Cost and management of asthma attacks treated in primary care (COAX Study)].
  • [Transliterated title] Coste y manejo de las crisis asmáticas atendidas en atención primaria (estudio COAX).
  • OBJECTIVES: To estimate the cost and characterize the management of asthma attacks in primary care.
  • Setting. 10 physician's offices at 9 primary care centers located in 5 provinces (Asturias, Barcelona, Cadiz, Madrid, and Valencia) of Spain.
  • CONCLUSIONS: Mean cost of each asthma attack treated in primary care was 166.7 (95% CI, 146.5-192.3), of which 80% were direct costs and 20% indirect costs.

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  • (PMID = 15946608.001).
  • [ISSN] 0212-6567
  • [Journal-full-title] Atencion primaria
  • [ISO-abbreviation] Aten Primaria
  • [Language] SPA
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Anti-Asthmatic Agents
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63. Kalinin AP, Bogatyrev OP, Poliakova GA, Beloshitskiĭ ME, Britvin TA: [Adrenal gland surgery]. Vestn Ross Akad Med Nauk; 2005;(11):43-9
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  • [Title] [Adrenal gland surgery].
  • The authors of the article analyze more than 30-year experience of surgical treatment of adrenal gland diseases, offering a detailed description of clinical and morphological features of the main nosological forms such as Itsenko-Cushing disease and syndrome, primary hyperaldosteronism, pheochromocytoma, incidentaloma, and malignant adrenal tumors.
  • The paper contains basic diagnostic criteria, indications to operative treatment, and extents of surgery for each of the diseases considered, as well as comparative analysis of peculiarities of conventional ("open"), and endoscopic adrenal gland surgeries.
  • The article demonstrates significance of various immunohistochemical markers in differentiation between malignant and benign adrenal tumors.

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  • (PMID = 16408654.001).
  • [ISSN] 0869-6047
  • [Journal-full-title] Vestnik Rossiiskoi akademii meditsinskikh nauk
  • [ISO-abbreviation] Vestn. Akad. Med. Nauk SSSR
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 16
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64. Lu J, Huang Y, Hong K, Liu YQ, Tian XJ, Zhang SD, Wang GL, Liu L, Ma LL: [Retroperitoneal laparoscopic adrenalectomy for larger adrenal tumor]. Beijing Da Xue Xue Bao; 2010 Aug 18;42(4):454-7
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  • [Title] [Retroperitoneal laparoscopic adrenalectomy for larger adrenal tumor].
  • OBJECTIVE: To evaluate the feasibility and safety of retroperitoneal laparoscopic adrenalectomy for larger adrenal tumor.
  • METHODS: A retrospective cohort study of patients who underwent retroperitoneal laparoscopic adrenalectomy in a single unit from July 2004 to December 2008 was undertaken, in which 53 cases were divided into 2 groups according to size as estimated by group A [n=13; age: 45+/-18 years; size: (7.6+/-1.2) cm, maximum diameter of tumor larger than 6 cm] and group B [n=40; age: (49+/-12) years; size: (4.0+/-0.9) cm, between 3 and 6 cm].
  • The pathology of most tumors in group A included medullary lipoma(30.8%), pheochromocytoma(23%) and ganglioneuroma(23%), the others included adenoma(32.5%), pheochromocytoma(25%) and ganglioneuroma(17.5%) in group B.
  • CONCLUSION: Retroperitoneal laparoscopic adrenalectomy has best value in patients with larger adrenal tumor and it is a minimally invasive and safe procedure for skillful surgeons in the treatment of tumor size larger than 6 cm.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy / methods. Lipoma / surgery. Pheochromocytoma / surgery

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  • (PMID = 20721263.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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65. Goel SR, Ponzo F, Friedman KP: Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG. Radiol Case Rep; 2009;4(3):306
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  • We present the case of a 61-year-old man who underwent I-123 metaiodobenzylguanidine (MIBG) scintigraphy based on clinical suspicion of pheochromocytoma.

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  • (PMID = 27307825.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4898006
  • [Keywords] NOTNLM ; MBIG, metaiodobenzylguanidine
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66. Ohnuma K, Yomo T, Asashima M, Kaneko K: Sorting of cells of the same size, shape, and cell cycle stage for a single cell level assay without staining. BMC Cell Biol; 2006;7:25
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  • The rat pheochromocytoma PC12 cell line, a neuronal cell line, was used for all experiments.
  • [MeSH-minor] Adrenal Gland Neoplasms / pathology. Animals. Cell Differentiation. Cell Proliferation. Cell Survival. DNA / analysis. Light. PC12 Cells. Pheochromocytoma / pathology. Rats

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  • [ISSN] 1471-2121
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  • [ISO-abbreviation] BMC Cell Biol.
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  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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67. Calsyn JD, Green RA, Davis GJ, Reilly CM: Adrenal pheochromocytoma with contralateral adrenocortical adenoma in a cat. J Am Anim Hosp Assoc; 2010 Jan-Feb;46(1):36-42
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  • [Title] Adrenal pheochromocytoma with contralateral adrenocortical adenoma in a cat.
  • An ultrasound revealed bilateral adrenal gland enlargement.
  • Histopathology was consistent with a cortical adenoma in the right adrenal gland and a pheochromocytoma in the left adrenal gland.
  • [MeSH-major] Adrenal Gland Neoplasms / veterinary. Adrenocortical Adenoma / veterinary. Cat Diseases / diagnosis. Pheochromocytoma / veterinary

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  • (PMID = 20045835.001).
  • [ISSN] 1547-3317
  • [Journal-full-title] Journal of the American Animal Hospital Association
  • [ISO-abbreviation] J Am Anim Hosp Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Kwon DJ, Lee YM, Hwang IS, Park CK, Yang BK, Cheong HT: Microtubule distribution in somatic cell nuclear transfer bovine embryos following control of nuclear remodeling type. J Vet Sci; 2010 Jun;11(2):93-101
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  • The proportion of embryos that underwent premature chromosome condensation (PCC) was increased by caffeine treatment but was reduced by roscovitine treatment (p < 0.05).
  • In conclusion, PCC is a favorable condition for the normal organization of microtubules, and inhibition of PCC can cause abnormal mitotic division of bovine SCNT embryos by causing microtubule dysfunction.

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  • (PMID = 20458148.001).
  • [ISSN] 1976-555X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Purines; 0 / roscovitine; 3G6A5W338E / Caffeine
  • [Other-IDs] NLM/ PMC2873821
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69. Ozawa N, Okamura T, Koyama K, Hamazawa Y, Senzaki H, Tanabe S, Ikemoto S, Inoue Y: Usefulness of F-18 FDG-PET in a long-term hemodialysis patient with renal cell carcinoma and pheochromocytoma. Ann Nucl Med; 2007 Jun;21(4):239-43
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  • [Title] Usefulness of F-18 FDG-PET in a long-term hemodialysis patient with renal cell carcinoma and pheochromocytoma.
  • A patient who had been on long-term hemodialysis (HD) was diagnosed as having renal cell carcinoma (RCC) and pheochromocytoma.
  • Abdominal computed tomography scanning demonstrated a right renal mass and a right adrenal mass, whereas positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) revealed increased accumulation in both the renal and adrenal masses.
  • FDG-PET is useful for detecting RCC in HD patients because FDG is not excreted in the urine, but it is difficult to distinguish pheochromocytoma from an adrenal metastasis by this imaging method.
  • [MeSH-major] Carcinoma, Renal Cell / complications. Carcinoma, Renal Cell / diagnosis. Fluorodeoxyglucose F18. Kidney Neoplasms / complications. Kidney Neoplasms / diagnosis. Pheochromocytoma / complications. Pheochromocytoma / diagnosis. Positron-Emission Tomography / methods. Radiopharmaceuticals. Renal Dialysis / methods
  • [MeSH-minor] Diagnosis, Differential. Humans. Kidney / pathology. Male. Middle Aged. Neoplasm Metastasis. Tomography, X-Ray Computed


70. Duquia RP, de Almeida HL Jr, Traesel M, Jannke HA: Cutaneous metastasis of pheochromocytoma in multiple endocrine neoplasia IIB. J Am Acad Dermatol; 2006 Aug;55(2):341-4
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  • [Title] Cutaneous metastasis of pheochromocytoma in multiple endocrine neoplasia IIB.
  • Pheochromocytoma is a rare tumor originating from neuroectodermic cells.
  • There are many familial forms of this tumor, including multiple endocrine neoplasia type II, Von Hippel-Lindau syndrome, and neurofibromatosis type I.
  • Skin manifestations of pheochromocytoma are rare, and cutaneous metastasis in patients with multiple endocrine neoplasia IIB has never been described.
  • The case of a patient with multiple endocrine neoplasia IIB who presented malignant pheochromocytoma with multiple cutaneous metastasis is described.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Multiple Endocrine Neoplasia Type 2b / pathology. Pheochromocytoma / secondary. Skin Neoplasms / secondary


71. Ballhausen D, Mittaz L, Boulat O, Bonafé L, Braissant O: Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain. Neuroscience; 2009 Dec 1;164(2):578-87
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  • Methylmalonyl-CoA mutase (MCM) and propionyl-CoA carboxylase (PCC) are the key enzymes of the catabolic pathway of propionate metabolism and are mainly expressed in liver, kidney and heart.
  • Both, MCM and PCC enzymes are co-expressed in neurons and found in all regions of the CNS.
  • Disease-specific metabolites such as methylmalonate, propionyl-CoA and 2-methylcitrate could thus be formed autonomously in the CNS and contribute to the pathophysiological mechanisms of neurotoxicity.
  • In rat embryos (E15.5 and E18.5), MCM and PCC show a much higher expression level in the entire CNS than in the liver, suggesting a different, but important function of this pathway during brain development.

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  • (PMID = 19699272.001).
  • [ISSN] 1873-7544
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Subunits; EC 4.1.1.41 / Methylmalonyl-CoA Decarboxylase; EC 5.4.99.2 / Methylmalonyl-CoA Mutase
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72. Zhang HN, Zhou JG, Qiu QY, Ren JL, Guan YY: ClC-3 chloride channel prevents apoptosis induced by thapsigargin in PC12 cells. Apoptosis; 2006 Mar;11(3):327-36
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  • We found that thapsigargin (TG), a specific inhibitor of the endoplasmic reticulum calcium ATPase, evoked apoptotic morphological changes (including cytoplasmic blebbing, condensation of nuclear chromatin, and the formation of apoptotic bodies), DNA laddering, and caspase-3 activation in PC12 cells (Pheochromocytoma-derived cell line).

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  • (PMID = 16520896.001).
  • [ISSN] 1360-8185
  • [Journal-full-title] Apoptosis : an international journal on programmed cell death
  • [ISO-abbreviation] Apoptosis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chloride Channels; 0 / ClC-3 channel; 0 / Enzyme Inhibitors; 0 / Oligonucleotides, Antisense; 67526-95-8 / Thapsigargin; EC 3.4.22.- / Caspase 3
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73. Liu X, Buffington JA, Tjalkens RB: NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines. Brain Res Mol Brain Res; 2005 Nov 18;141(1):39-47
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  • Pheochromocytoma (PC12) cells differentiated with nerve growth factor (NGF) were co-cultured with primary astrocytes and exposed to Mn and tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma).
  • Apoptosis in PC12 neurons required the presence of astrocytes and was blocked by overexpression of a phosphorylation-deficient mutant of IkappaBalpha (S32/36A) in astrocytes that prevented induction of NOS2.
  • Pharmacologic inhibition of NOS2 with (+/-)-2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT) significantly reduced neuronal apoptosis, and the addition of low concentrations of the NO donor, S-nitroso-N-acetylpenicillamine (SNAP), to neurons cultured without astrocytes was sufficient to recover the apoptotic phenotype following exposure to Mn and TNF-alpha/IFN-gamma.

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  • (PMID = 16168523.001).
  • [ISSN] 0169-328X
  • [Journal-full-title] Brain research. Molecular brain research
  • [ISO-abbreviation] Brain Res. Mol. Brain Res.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES012941
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cytokines; 0 / I-kappa B Proteins; 0 / NF-kappa B; 139874-52-5 / NF-kappaB inhibitor alpha; 31C4KY9ESH / Nitric Oxide; 42Z2K6ZL8P / Manganese; 79032-48-7 / S-Nitroso-N-Acetylpenicillamine; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 3.4.22.- / Caspases
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74. Zakrzewska A, Schnell PO, Striet JB, Hui A, Robbins JR, Petrovic M, Conforti L, Gozal D, Wathelet MG, Czyzyk-Krzeska MF: Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and CBP in oxygen-sensitive cells. J Neurochem; 2005 Sep;94(5):1288-96
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  • It is also cell-type specific and occurs in pheochromocytoma PC12 cells and the carotid body of rats but not in hepatoblastoma cells.
  • On the other hand, p300 hyperphosphorylation is inhibited by several different inhibitors of the glucose metabolic pathway from generation of NADH by glyceraldehyde 3-phosphate dehydrogenase, through the transfer of NADH through the glycerol phosphate shuttle to ubiquinone and complex III of the mitochondrial respiratory chain.
  • We propose that the NADH glycerol phosphate shuttle participates in generating a pool of ATP that serves either as a co-factor or a modulator of the kinases involved in the phosphorylation of p300/CBP during hypoxia.

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  • (PMID = 16000154.001).
  • [ISSN] 0022-3042
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL069932; United States / NHLBI NIH HHS / HL / R01 HL058687; United States / NHLBI NIH HHS / HL / HL58687; United States / NHLBI NIH HHS / HL / HL69932; United States / NHLBI NIH HHS / HL / HL66312; United States / NHLBI NIH HHS / HL / R01 HL066312
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ep300 protein, rat; 0 / Nuclear Proteins; 0 / Trans-Activators; 85166-31-0 / Inositol 1,4,5-Trisphosphate; EC 2.3.1.48 / E1A-Associated p300 Protein; IY9XDZ35W2 / Glucose; S88TT14065 / Oxygen; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS7814; NLM/ PMC1411962
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75. Tomaselli B, Podhraski V, Heftberger V, Böck G, Baier-Bitterlich G: Purine nucleoside-mediated protection of chemical hypoxia-induced neuronal injuries involves p42/44 MAPK activation. Neurochem Int; 2005 Jun;46(7):513-21
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  • O(2)-sensitive neuronal pheochromocytoma (PC12)-cells, which are widely used as a model system for sympathetic ganglion-like neurons, were subjected to chemical hypoxia induced with rotenone, an inhibitor of mitochondrial complex I.

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  • (PMID = 15843045.001).
  • [ISSN] 0197-0186
  • [Journal-full-title] Neurochemistry international
  • [ISO-abbreviation] Neurochem. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Neuroprotective Agents; 0 / Purine Nucleosides; 0 / Uncoupling Agents; 03L9OT429T / Rotenone; 12133JR80S / Guanosine; 5A614L51CT / Inosine; 9061-61-4 / Nerve Growth Factor; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; K72T3FS567 / Adenosine
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76. Shchepotin IB, Zotov AS: [Multiple endocrine neoplasia syndrome]. Vopr Onkol; 2005;51(6):722-7
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  • [Title] [Multiple endocrine neoplasia syndrome].
  • [MeSH-major] Multiple Endocrine Neoplasia / diagnosis. Multiple Endocrine Neoplasia / therapy
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Humans. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / therapy. Multiple Endocrine Neoplasia Type 1 / diagnosis. Multiple Endocrine Neoplasia Type 1 / therapy. Multiple Endocrine Neoplasia Type 2a / diagnosis. Multiple Endocrine Neoplasia Type 2a / therapy. Multiple Endocrine Neoplasia Type 2b / diagnosis. Multiple Endocrine Neoplasia Type 2b / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy. Pituitary Gland, Anterior. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy. Proto-Oncogene Proteins c-ret / genetics. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / therapy

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  • (PMID = 17037044.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human
  • [Number-of-references] 7
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77. Unger N, Deutschbein T, Walz MK, Mann K, Petersenn S: The value of immunoassays for metanephrines in the biochemical diagnosis of pheochromocytomas. Horm Metab Res; 2009 Sep;41(9):676-9
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  • [Title] The value of immunoassays for metanephrines in the biochemical diagnosis of pheochromocytomas.
  • An undiagnosed pheochromocytoma may result in life-threatening consequences.
  • The diagnosis of pheochromocytoma is based on the overproduction of catecholamines.
  • However, they may be falsely negative in patients with a biochemically-silent or periodically-secreting pheochromocytoma.
  • Urinary metanephrines are determined by high-pressure liquid chromatography (HPLC) in an increasing number of laboratories, whereas plasma metanephrines measured by HPLC are available in specialised centres only.
  • Measurement of metanephrines instead of catecholamines by either technique improved the diagnostic accuracy for the diagnosis of pheochromocytomas.
  • Determination of plasma free metanephrines demonstrated a higher accuracy than their urinary counterparts.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Immunoassay / methods. Metanephrine / urine. Pheochromocytoma / diagnosis

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  • (PMID = 19557670.001).
  • [ISSN] 1439-4286
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5001-33-2 / Metanephrine
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78. Cheng SP, Saunders BD, Gauger PG, Doherty GM: Laparoscopic partial adrenalectomy for bilateral pheochromocytomas. Ann Surg Oncol; 2008 Sep;15(9):2506-8
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  • [Title] Laparoscopic partial adrenalectomy for bilateral pheochromocytomas.
  • BACKGROUND: Patients with hereditary pheochromocytoma are at risk of the development of bilateral disease.
  • Partial adrenalectomy can preserve adrenal function to avoid the morbidity associated with medical adrenal replacement.
  • METHODS: A 13-year-old patient with von Hippel-Lindau disease was found to have high urinary metanephrines and normetanephrines.
  • Computed tomography showed bilateral adrenal tumors (2.5 cm on the right side and 0.9 cm on the left).
  • MIBG scan showed positive uptake in the right adrenal gland without extra-adrenal uptake.
  • Intraoperative ultrasound was performed to determine the line of tumor excision, which was carefully planned to preserve most of the normal-appearing gland.
  • The main adrenal veins of both sides were precisely preserved.
  • Pathologic examination confirmed bilateral entirely excised pheochromocytomas.
  • CONCLUSION: Laparoscopic partial adrenalectomy for bilateral pheochromocytomas is safe and technically feasible.
  • It should be considered the treatment of choice for hereditary pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Pheochromocytoma / surgery
  • [MeSH-minor] Adolescent. Humans. Tomography, X-Ray Computed. von Hippel-Lindau Disease / complications

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  • (PMID = 18618188.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Sood J, Jayaraman L, Kumra VP, Chowbey PK: Laparoscopic approach to pheochromocytoma: is a lower intraabdominal pressure helpful? Anesth Analg; 2006 Feb;102(2):637-41
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  • [Title] Laparoscopic approach to pheochromocytoma: is a lower intraabdominal pressure helpful?
  • Norepinephrine and epinephrine blood levels were measured preoperatively, during endotracheal intubation, carboperitoneum, surgical manipulation of tumor just before the ligation of the adrenal vein, and tracheal extubation; the hemodynamic variables were recorded.
  • Surgical manipulation of the tumor resulted in a significant increase in MAP and norepinephrine levels in group A (P = 0.007 and P = 0.0001, respectively).
  • The epinephrine levels did not change as much because the tumor was probably predominantly norepinephrine-secreting.
  • We conclude that a low intraabdominal pressure of 8-10 mm Hg causes less catecholamine release and fewer hemodynamic fluctuations.
  • [MeSH-major] Abdomen / physiology. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Laparoscopy. Pheochromocytoma / surgery

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  • (PMID = 16428576.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide; X4W3ENH1CV / Norepinephrine; YKH834O4BH / Epinephrine
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80. Bolte K, Kawach O, Prechtl J, Gruenheit N, Nyalwidhe J, Maier UG: Complementation of a phycocyanin-bilin lyase from Synechocystis sp. PCC 6803 with a nucleomorph-encoded open reading frame from the cryptophyte Guillardia theta. BMC Plant Biol; 2008;8:56
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  • [Title] Complementation of a phycocyanin-bilin lyase from Synechocystis sp. PCC 6803 with a nucleomorph-encoded open reading frame from the cryptophyte Guillardia theta.
  • RESULTS: Orf222, one of the uncharacterized nucleomorph-specific open reading frames of the cryptophyte Guillardia theta, shows homology to slr1649 of Synechocystis sp. PCC 6803.
  • PCC 7002 was characterized to encode a phycocyanin-beta155-bilin lyase.
  • PCC 6803 slr1649-encoded protein also acts as a bilin lyase, and additionally contributes to linker attachment and/or stability of phycobilisomes.
  • PCC 6803 can be complemented in vivo by the nucleomorph-encoded open reading frame orf222.
  • PCC 6803 and indicate that after separating from a common ancestor protein, the phycoerythrin lyase from Guillardia theta has retained its capacity to couple a bilin group to other phycobiliproteins.

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  • (PMID = 18485196.001).
  • [ISSN] 1471-2229
  • [Journal-full-title] BMC plant biology
  • [ISO-abbreviation] BMC Plant Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Phycobilisomes; EC 4.- / Lyases; EC 4.4.- / phycocyanin alpha-subunit phycocyanobilin lyase
  • [Other-IDs] NLM/ PMC2408579
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81. Zhang P, Sicora CI, Vorontsova N, Allahverdiyeva Y, Battchikova N, Nixon PJ, Aro EM: FtsH protease is required for induction of inorganic carbon acquisition complexes in Synechocystis sp. PCC 6803. Mol Microbiol; 2007 Aug;65(3):728-40
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  • [Title] FtsH protease is required for induction of inorganic carbon acquisition complexes in Synechocystis sp. PCC 6803.
  • Cyanobacteria possess a complex CO(2)-concentrating mechanism (CCM), which is induced by low inorganic carbon conditions.
  • To investigate the involvement of proteases in the processes of induction and degradation of the CCM complexes, we studied the FtsH2 (DeltaSlr0228) and Deg-G (DeltaSlr1204/DeltaSll1679/DeltaSll1427) protease mutants of Synechocystis sp. PCC 6803.
  • [MeSH-major] Bacterial Proteins / metabolism. Carbon Compounds, Inorganic / metabolism. Synechocystis / enzymology

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  • (PMID = 17635189.001).
  • [ISSN] 0950-382X
  • [Journal-full-title] Molecular microbiology
  • [ISO-abbreviation] Mol. Microbiol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/E006388/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Carbon Compounds, Inorganic; 0 / Proteome; 0 / RNA, Messenger; 142M471B3J / Carbon Dioxide; 9I3SDS92WY / Diuron; PLG39H7695 / Paraquat
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82. Myśliwiec J, Rudy A, Siewko K, Myśliwiec P, Pułka M, Górska M: [Diagnostic difficulties in adrenal incidentaloma--analysis of 125 cases]. Endokrynol Pol; 2007 Sep-Oct;58(5):417-21
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  • [Title] [Diagnostic difficulties in adrenal incidentaloma--analysis of 125 cases].
  • [Transliterated title] Trudności diagnostyczne dotyczace 125 przypadkowo wykrytych guzów nadnerczy.
  • The patients were clinically and hormonally examined (metanephrines in daily urine collection, daily cortisol rhythm, short dexamethasone test, aldosterone, and renin plasma activity, Na, K levels in the serum) as well as computer tomography of the adrenal glands were performed.
  • Adenoma was confirmed in 25 patients (in 7 subclinical Cushing syndrome was diagnosed, in 2 Conn disease, in 16 inactive changes), phaeochromocytoma in 6 patients, cysts in 3, lipoma in 2, carcinoma in one, in 4 patients metastases (in 2 of kidney carcinoma, in 1 of malignant melanoma and in 1 of planocellular carcinoma) and in one oncocytoma.
  • CONCLUSIONS: Qualification for adrenalectomy requires an assessment of tumor's enlargement, its tissue density, morphology and growth dynamics.
  • The decision as to proceeding with adrenal incidentaloma should be individualized based on clinical symptoms, hormonal tests and tumor morphology.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / surgery
  • [MeSH-minor] Adenoma / classification. Adenoma / diagnosis. Adenoma / surgery. Adrenalectomy. Diagnosis, Differential. Female. Humans. Incidental Findings. Male. Retrospective Studies

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  • (PMID = 18058737.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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83. Vestergaard P, Vestergaard EM, Brockstedt H, Christiansen P: Codon Y791F mutations in a large kindred: is prophylactic thyroidectomy always indicated? World J Surg; 2007 May;31(5):996-1001; discussion 1002-4
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  • BACKGROUND: RET proto-oncogene mutations are associated with medullary thyroid carcinomas usually requiring preventive thyroidectomy in gene carriers.
  • We present a large kindred with the Y791F mutation in the RET proto-oncogene that did not have medullary thyroid carcinomas.
  • PATIENTS AND METHODS: Eight members of a Danish family with the Y791F mutation participated.
  • We found no significant differences in basal serum calcitonin concentrations between gene carriers (mean +/- SD: 0.16 +/- 0.54 pmol/l, n = 11) and non-gene carriers (0.55 +/- 0.86 pmol/l, n = 6, 2 P = 0.29).
  • None showed signs of primary hyperparathyroidism or phaeochromocytoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Codon. Female. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Male. Middle Aged. Pedigree. Penetrance. Polymerase Chain Reaction. Statistics, Nonparametric

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  • (PMID = 17483988.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret
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84. Fliedner SM, Breza J, Kvetnansky R, Powers JF, Tischler AS, Wesley R, Merino M, Lehnert H, Pacak K: Tyrosine hydroxylase, chromogranin A, and steroidogenic acute regulator as markers for successful separation of human adrenal medulla. Cell Tissue Res; 2010 Jun;340(3):607-12
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  • [Title] Tyrosine hydroxylase, chromogranin A, and steroidogenic acute regulator as markers for successful separation of human adrenal medulla.
  • This is difficult to obtain from pheochromocytomas (PHEOs), rare chromaffin tumors derived from adrenal medulla.
  • The two options for obtaining adrenal tissue are:.
  • Access to high quality normal adrenal tissue is limited.
  • Adjacent normal adrenal tissue can almost never be obtained from resected PHEOs, because they often replace the entire medulla or are well-encapsulated.
  • If a margin of normal adrenal is attached to a resected PHEO, it seldom contains any medulla.
  • The clean separation of medulla and cortex is further complicated, because their border is convoluted, and because adult adrenal consists of approximately 90% cortex.
  • Thus, the quality of separation has to be evaluated with specific medullary and cortical markers.
  • We describe the successful dissection of highly pure, medullary tissue from adrenals snap-frozen upon resection during radical nephrectomy or after brain death.
  • Separation quality has been verified by quantitative reverse transcription with polymerase chain reaction for the medullary enzymes, tyrosine hydroxylase, and chromogranin A, and for the cortical enzyme, steroidogenic acute regulator.
  • [MeSH-major] Adrenal Medulla / enzymology. Chromogranin A / metabolism. Phosphoproteins / metabolism. Tissue Culture Techniques / methods. Tyrosine 3-Monooxygenase / metabolism
  • [MeSH-minor] Adrenal Cortex / pathology. Aged. Biomarkers / metabolism. Female. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 20440513.001).
  • [ISSN] 1432-0878
  • [Journal-full-title] Cell and tissue research
  • [ISO-abbreviation] Cell Tissue Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HD008735-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chromogranin A; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / steroidogenic acute regulatory protein; EC 1.14.16.2 / Tyrosine 3-Monooxygenase
  • [Other-IDs] NLM/ NIHMS750167; NLM/ PMC4714581
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85. Hosli EJ, Elsinga J, Buitendijk SE, Assendelft WJ, van der Pal-de Bruin KM: Women's motives for not participating in preconception counseling: qualitative study. Community Genet; 2008;11(3):166-70
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  • We aimed to identify women's motives for not responding to an invitation for preconception counseling (PCC) from their general practitioner.
  • METHODS: A purposive sample of 11 women who did not respond to an invitation for PCC and who became pregnant within 1 year was interviewed.
  • RESULTS: Three key themes influencing nonresponse emerged from the data: perceived knowledge, perceived lack of risk and a misunderstanding of the aim of PCC.
  • CONCLUSION: For successful future implementation of PCC, a more tailored approach may be necessary for certain (groups of) women, addressing the reasons why women do not consider themselves part of the target group for PCC.
  • [MeSH-major] Directive Counseling. Motivation. Patient Acceptance of Health Care / psychology. Preconception Care. Women / psychology

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18376113.001).
  • [ISSN] 1422-2833
  • [Journal-full-title] Community genetics
  • [ISO-abbreviation] Community Genet
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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86. Vassiliou MC, Laycock WS: Laparoscopic adrenalectomy for pheochromocytoma: take the vein last? Surg Endosc; 2009 May;23(5):965-8
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  • [Title] Laparoscopic adrenalectomy for pheochromocytoma: take the vein last?
  • BACKGROUND: Traditionally, the adrenal vein has been ligated early during excision of a pheochromocytoma.
  • This study aimed to demonstrate the safety and efficacy of delayed adrenal vein ligation during laparoscopic adrenalectomy for pheochromocytoma.
  • METHODS: A retrospective review of all laparoscopic adrenalectomies for pheochromocytoma from 1997 to 2007 was conducted.
  • All the patients had confirmed histologic evidence of pheochromocytoma.
  • The procedures were performed using the same technique, which involved division of the adrenal vein late in the procedure after the gland had been dissected free.
  • CONCLUSIONS: Delayed adrenal vein ligation during laparoscopic adrenalectomy for pheochromocytoma is safe and effective.
  • Dividing the vein late is an alternative approach to laparoscopic excision of adrenal pheochromocytoma and should be considered in appropriate situations.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenal Glands / blood supply. Adrenalectomy / methods. Pheochromocytoma / surgery. Veins / surgery


87. Pasquali D, Rossi V, Conzo G, Pannone G, Bufo P, De Bellis A, Renzullo A, Bellastella G, Colao A, Vallone G, Bellastella A, Sinisi AA: Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cells. J Mol Endocrinol; 2008 Jun;40(6):263-71
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  • [Title] Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cells.
  • Surgery is the primary therapy for pheochromocytoma (PHEO), a catecholamine-producing tumor.
  • We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
  • Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
  • OCT 10(-6) M and SOM230 10(-7) M significantly reduced catecholamine levels.
  • Our results indicate that while both OCT and SOM230 modulate cell growth and apoptosis and catecholamine levels in Pheo-c through specific receptors, SOM230 is more effective.
  • [MeSH-major] Apoptosis / drug effects. Catecholamines / metabolism. Pheochromocytoma / pathology. Somatostatin / analogs & derivatives
  • [MeSH-minor] Adult. Caspase 3 / metabolism. Cell Proliferation / drug effects. Cell Survival / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Humans. Immunohistochemistry. Intracellular Space / drug effects. Intracellular Space / metabolism. Middle Aged. Octreotide / pharmacology. Poly(ADP-ribose) Polymerases / metabolism. Receptors, Somatostatin / genetics. Receptors, Somatostatin / metabolism. Tumor Cells, Cultured

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  • (PMID = 18502819.001).
  • [ISSN] 1479-6813
  • [Journal-full-title] Journal of molecular endocrinology
  • [ISO-abbreviation] J. Mol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Receptors, Somatostatin; 51110-01-1 / Somatostatin; 98H1T17066 / pasireotide; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspase 3; RWM8CCW8GP / Octreotide
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88. Calender A, Dupasquier S, Cordier M, Zhang CX, Groupe d'Etude des Tumeurs Endocrines: [Genetics of endocrine tumours]. Ann Pathol; 2005 Dec;25(6):463-86
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  • The syndrome of type 1 multiple endocrine neoplasia (MEN-1) is one of the best known; this autosomal dominant hereditary syndrome predisposes to the development of endocrine tumors of the pituitary, the parathyroids, the foregut and the adrenals.
  • Type 2 multiple endocrine neoplasia (MEN-2) is an autosomal dominant hereditary syndrome associated with the development of medullary carcinomas of the thyroid, pheochromocytomas and hyperparathyroidism; the corresponding gene, RET, encodes a transmembrane receptor with tyrosine kinase activity.
  • Endocrine tumors are also associated with non Hippel-Lindau disease and with phacomatoses, such as type 1 neurofibromatosis and tuberous sclerosis.
  • Finally, isolated familial syndromes of endocrine tumors have been described: isolated familial hyperparathyroidism type II (HRPT2), associated with alterations in a gene coding for an original protein, parafibromin, or isolated familial syndromes of pheochromocytomas and paragangliomas (PRG) associated with mutations in the genes SDHB, SDHC or SDHD, which encode succinate-dehydrogenase subunits.
  • The understanding of the genetic mechanisms underlying these syndromes of predisposition is essential for the diagnosis and management of these patients and their family; it also gives insight on the molecular mechanisms of endocrine tumorigenesis.
  • [MeSH-major] Endocrine Gland Neoplasms / genetics
  • [MeSH-minor] Adrenal Gland Neoplasms / genetics. Chromosome Mapping. Humans. Multiple Endocrine Neoplasia Type 1. Multiple Endocrine Neoplasia Type 2a / genetics. Multiple Endocrine Neoplasia Type 2b. Pheochromocytoma / genetics. Proto-Oncogene Proteins c-ret / genetics

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  • (PMID = 16735973.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret
  • [Number-of-references] 113
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89. Horger M, Fritz J, Bares R, Müssig K: [Diagnosis of hyperfunctioning adrenal masses]. Rofo; 2006 Dec;178(12):1171-6
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  • [Title] [Diagnosis of hyperfunctioning adrenal masses].
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / secretion. Pheochromocytoma / diagnosis. Pheochromocytoma / secretion
  • [MeSH-minor] Adrenal Gland Diseases / diagnosis. Adrenal Gland Diseases / metabolism. Aldosterone / biosynthesis. Cushing Syndrome / diagnosis. Cysts / diagnosis. Diagnosis, Differential. Female. Humans. Hydrocortisone / biosynthesis. Male. Middle Aged. Paraganglioma / diagnosis. Paraganglioma / secretion

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  • (PMID = 17396301.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; WI4X0X7BPJ / Hydrocortisone
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90. Forchhammer K: The network of P(II) signalling protein interactions in unicellular cyanobacteria. Adv Exp Med Biol; 2010;675:71-90
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  • We have investigated in some detail the P(II) signalling protein, its signal perception and its interactions with receptors in the unicellular cyanobacteria Synechococcus elongatus PCC 7942 and Synechocystis PCC 6803 and have performed comparative analysis with Arabidopsis thaliana P(II)-NAGK interaction.
  • This chapter will summarize these studies and will describe the emerging picture of a complex network of P(II) protein interactions in the unicellular cyanobacteria.

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  • (PMID = 20532736.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PII Nitrogen Regulatory Proteins
  • [Number-of-references] 56
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91. Kolomeyevskaya N, Blazo M, Van den Veyver I, Strehlow S, Aagaard-Tillery KM: Pheochromocytoma and Von Hippel-Lindau in pregnancy. Am J Perinatol; 2010 Mar;27(3):257-63
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  • [Title] Pheochromocytoma and Von Hippel-Lindau in pregnancy.
  • Pheochromocytoma is an infrequent but well-acknowledged primary cause of malignant hypertension in pregnancy.
  • Although the majority of pheochromocytomas are sporadic, those that present as bilateral or multifocal tumors may be a manifestation of a rare cancer susceptibility syndrome, such as Von Hippel-Lindau (VHL).
  • Gravidae with unrecognized pheochromocytoma are at risk for recurrent paroxysmal hypertensive crises with ensuant maternal and fetal risks.
  • To further illustrate the challenges of management of pheochromocytoma and VHL in pregnancy, we present two illustrative cases.
  • In the first, a multigravida presented with an intrauterine fetal demise and malignant hypertension and a concurrent diagnosis of bilateral pheochromocytomas.
  • A missense mutation in exon 3 of the VHL gene was identified, confirming the diagnosis of VHL type 2C.
  • In the second case, a multigravida with a prior diagnosis of VHL syndrome but sporadic follow-up underwent renal and adrenal imaging surveillance as part of her prenatal care.
  • Although she was normotensive and clinically asymptomatic, such imaging enabled the detection of bilateral pheochromocytomas.
  • In summary, in this report we discuss our management in gravidae with pheochromocytoma and VHL, emphasizing current recommendations pertaining to obstetric management, genetic testing, and long-term follow-up.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Pheochromocytoma / complications. Pregnancy Complications, Neoplastic / diagnosis. von Hippel-Lindau Disease / complications
  • [MeSH-minor] Adult. Female. Humans. Hypertension, Pregnancy-Induced / diagnosis. Hypertension, Pregnancy-Induced / genetics. Pregnancy. Prenatal Diagnosis / methods. Risk Factors. Young Adult


92. Ozbay A, Obukhau A, Buhl L, Brøndt Hartlev L, Løgstrup Poulsen P: Adrenal pheochromocytoma producing vasoactive intestinal peptide and masking hypertension. Horm Res; 2008;70(3):188-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal pheochromocytoma producing vasoactive intestinal peptide and masking hypertension.
  • AIM: To report a case of a pheochromocytoma secreting vasoactive intestinal peptide (VIP).
  • Initially gastrointestinal investigations were carried out based on longstanding diarrhea with hypopotassemia, but radiological imaging revealed a unilateral adrenal mass.
  • Biochemical testing showed increased levels of catecholamine and VIP, and (123)I-metaiodobenzylguanidine scintigraphy confirmed the adrenal origin as well as the diagnosis of a VIP-producing pheochromocytoma.
  • The patient underwent surgical removal of the tumor which led to relief of symptoms and normalized laboratory values.
  • CONCLUSION: This case report focuses on the protean mode of presentation seen in pheochromocytomas as well as their capacity to produce several neuropeptides, ultimately intensifying the need for early examination for this condition despite unrelated symptoms.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Hypertension / diagnosis. Pheochromocytoma / metabolism. Vasoactive Intestinal Peptide / biosynthesis


93. Kutsuna S, Nakahira Y, Katayama M, Ishiura M, Kondo T: Transcriptional regulation of the circadian clock operon kaiBC by upstream regions in cyanobacteria. Mol Microbiol; 2005 Sep;57(5):1474-84
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  • In the cyanobacterium, Synechococcus elongatus PCC 7942, the kaiBC operon is upregulated by the KaiA protein and downregulated by the KaiC protein to generate circadian oscillation.
  • Most of the examined sequences drove rhythmic expression of a luxAB reporter that was similar to the expression driven by the kaiBC promoter (PkaiBC) and responded to the overexpression of kaiA or kaiC, even in a promoter activity range of 1-8000%.

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  • (PMID = 16102014.001).
  • [ISSN] 0950-382X
  • [Journal-full-title] Molecular microbiology
  • [ISO-abbreviation] Mol. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Circadian Rhythm Signaling Peptides and Proteins; 0 / KaiA protein, cyanobacteria; 0 / KaiB protein, cyanobacteria; 0 / KaiC protein, cyanobacteria; EC 1.13.12.- / Luciferases
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94. Golan A, Kerem Z, Tun OM, Luzzatto T, Lipsky A, Yedidia I: Combining flow cytometry and gfp reporter gene for quantitative evaluation of Pectpbacterium carotovorum ssp. carotovorum in Ornithogalum dubium plantlets. J Appl Microbiol; 2010 Apr;108(4):1136-44
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  • AIMS: Ornithogalum dubium is a natural host of the soft rot pathogen Pectobacterium carotovorum ssp. carotovorum (Pcc).
  • The present study was aimed to develop a quantification system for Pcc expressing a gfp reporter gene, using fluorescent activated cell sorter (FACS) in planta.
  • This allowed quantification of the bacteria, with no further need to culture, dilute or plate the cells.
  • Micropropagation tools were developed to produce uniform plantlets of O. dubium, which were either inoculated with increasing concentrations of Pcc or elicited for resistance towards Pcc using methyl jasmonate.
  • CONCLUSIONS: The FACS based quantification approach of Pcc was found accurate, reproducible and time saving, thus useful for counting bacteria in planta.
  • SIGNIFICANCE AND IMPACT OF THE STUDY: The combination of time- and cost-saving approach for Pcc quantification with efficient screening tools during early stages of micropropagation may facilitate the preliminary process of selection for resistant cultivars.

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  • (PMID = 19732215.001).
  • [ISSN] 1365-2672
  • [Journal-full-title] Journal of applied microbiology
  • [ISO-abbreviation] J. Appl. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acetates; 0 / Cyclopentanes; 0 / Oxylipins; 0 / Plant Growth Regulators; 1211-29-6 / methyl jasmonate; 147336-22-9 / Green Fluorescent Proteins
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95. Maheswaran M, Ziegler K, Lockau W, Hagemann M, Forchhammer K: PII-regulated arginine synthesis controls accumulation of cyanophycin in Synechocystis sp. strain PCC 6803. J Bacteriol; 2006 Apr;188(7):2730-4
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  • [Title] PII-regulated arginine synthesis controls accumulation of cyanophycin in Synechocystis sp. strain PCC 6803.
  • The cyanobacterium Synechocystis sp. strain PCC 6803 accumulates cyanophycin following a transition from nitrogen-limited to nitrogen-excess conditions.

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  • (PMID = 16547064.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / PII Nitrogen Regulatory Proteins; 0 / Plant Proteins; 0 / cyanophycin; 94ZLA3W45F / Arginine
  • [Other-IDs] NLM/ PMC1428389
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96. Zhang HN, An CN, Xu M, Guo DA, Li M, Pu XP: Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin. Biol Pharm Bull; 2009 Nov;32(11):1866-9
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  • [Title] Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin.
  • Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) with the presence of alpha-synuclein inclusions termed Lewy bodies.
  • However, the effects of PAc on tyrosine hydroxylase (TH) and alpha-synuclein in rat pheochromocytoma (PC12) cells treated with 1-methyl-4-phenylpyridinium ion (MPP(+)) remains unclear.
  • [MeSH-major] Dopamine / metabolism. Hydroxybenzoates / pharmacology. Neurotoxins / pharmacology. Pheochromocytoma / pathology

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  • (PMID = 19881299.001).
  • [ISSN] 1347-5215
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hydroxybenzoates; 0 / Neurotoxins; 0 / alpha-Synuclein; 36R5QJ8L4B / protocatechuic acid; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; VTD58H1Z2X / Dopamine
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97. Bortnik M, Occhetta E, Marino P: Orthostatic hypotension as an unusual clinical manifestation of pheochromocytoma: a case report. J Cardiovasc Med (Hagerstown); 2008 Aug;9(8):839-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orthostatic hypotension as an unusual clinical manifestation of pheochromocytoma: a case report.
  • Pheochromocytoma is a rare endocrine tumor which can have a highly variable presentation related to increased catecholamine secretion.
  • We report the case of a 74-year-old man in whom recurrent episodes of syncope due to orthostatic hypotension were the only clinical manifestations of this challenging entity.
  • Diagnosis of pheochromocytoma was achieved by biochemical test samples and computed tomography scans.
  • Surgical excision of the tumor resulted in clinical improvement with normalization of catecholamine concentrations and no more episodes of orthostatic hypotension during a follow-up of 24 months.
  • Although rare, pheochromocytoma may frequently cause disorders of orthostatic tolerance; because of its meaningful implications, screening for this entity should be considered in case of recurrent syncopal episodes due to new-onset orthostatic hypotension.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Hypotension, Orthostatic / etiology. Pheochromocytoma / complications
  • [MeSH-minor] Aged. Blood Pressure. Catecholamines / blood. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 18607252.001).
  • [ISSN] 1558-2027
  • [Journal-full-title] Journal of cardiovascular medicine (Hagerstown, Md.)
  • [ISO-abbreviation] J Cardiovasc Med (Hagerstown)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catecholamines
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98. Virseda Rodríguez JA, Martínez Ruiz J, Carrión López P, Martínez Sanchiz C, Donate Moreno MJ, Pastor Navarro H, Hernández López A: [Pheochromocytoma: more than a decade of experience. Review of the literature]. Actas Urol Esp; 2010 Nov;34(10):888-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pheochromocytoma: more than a decade of experience. Review of the literature].
  • [Transliterated title] Feocromocitoma: más de una década de experiencia. Revisión de la literatura.
  • OBJECTIVES: We present 18 patients with pheochromocytoma in the past 12 years.
  • Four patients had a familial syndrome hereditary.
  • For the clinical study was made and plasma catecholamines and metanephrines in urine for 24h and subjected to control blood pressure before surgery and beta blockers.
  • CONCLUSIONS: Pheochromocytoma in a threatening disease by cardiovascular disease, which needs to perform an analytical and functional.
  • Surgical treatment, by open or laparoscopic surgery, depending on the characteristics of the tumor and the patient, is satisfactory and comparable results.
  • [MeSH-major] Adrenal Gland Neoplasms. Pheochromocytoma


99. Genome display tool: visualizing features in complex data sets. Source Code Biol Med; 2007 Feb 14;2:1
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  • [Title] Genome display tool: visualizing features in complex data sets.
  • The functionality of GDT is demonstrated by comparing the results of two predictions of recent horizontal transfer events in the genome of Synechocystis PCC-6803.

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  • (PMID = 17300731.001).
  • [ISSN] 1751-0473
  • [Journal-full-title] Source code for biology and medicine
  • [ISO-abbreviation] Source Code Biol Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1805442
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100. Verdú Rotellar JM, Barroso A, Bernáldez MJ, Domíngueza M, Pie M, Sancho F, Simó M, Domingo M: Beta-blocker treatment of stable heart failure in primary care. Rev Esp Cardiol; 2009 Oct;62(10):1141-8
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  • [Title] Beta-blocker treatment of stable heart failure in primary care.
  • INTRODUCTION AND OBJECTIVES: Beta-blocker treatment of stable heart failure in primary care.
  • The objective was to evaluate the feasibility and tolerability of uptitrating beta-blockers in patients with stable systolic heart failure seen in primary care.
  • The study was conducted in two primary care centers in Barcelona, Spain.
  • Appropriately trained primary care physicians can uptitrate beta-blockers in heart failure patients without undue concern.
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Primary Health Care. Prospective Studies

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  • (PMID = 19793520.001).
  • [ISSN] 1579-2242
  • [Journal-full-title] Revista española de cardiología
  • [ISO-abbreviation] Rev Esp Cardiol
  • [Language] eng; spa
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Adrenergic alpha-Antagonists; 0 / Carbazoles; 0 / Propanolamines; 0K47UL67F2 / carvedilol; Y41JS2NL6U / Bisoprolol
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