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Items 1 to 100 of about 488
1. Mun KS, Pailoor J, Chan KS, Pillay B: Extra-adrenal paraganglioma: presentation in three uncommon locations. Malays J Pathol; 2009 Jun;31(1):57-61
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  • [Title] Extra-adrenal paraganglioma: presentation in three uncommon locations.
  • Extra-adrenal paragangliomata are uncommon entities.
  • We report three instructive cases of extra-adrenal paraganglioma which were found in unusual sites such as urinary bladder, thyroid gland and on the wall of the inferior vena cava.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / pathology. Thyroid Neoplasms / pathology. Urinary Bladder Neoplasms / pathology. Vascular Neoplasms / pathology. Vena Cava, Inferior / pathology

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  • (PMID = 19694315.001).
  • [ISSN] 0126-8635
  • [Journal-full-title] The Malaysian journal of pathology
  • [ISO-abbreviation] Malays J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / S100 Proteins; 0 / Synaptophysin
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2. Chatterjee P, Singh A, Ayyappan A, Nair A: Extra-adrenal retroperitoneal paraganglioma associated with duplication of inferior vena cava. J Radiol Case Rep; 2008;2(3):25-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal retroperitoneal paraganglioma associated with duplication of inferior vena cava.
  • If this tissue aggregates in the adrenal medulla pheochromocytoma may arise.
  • When it remains in the paraaortic sites it could develop into extra-adrenal, retroperitoneal paraganglioma.
  • We report a case of extra-adrenal paraganglioma in the renal hilum intimately related to the left side of a double inferior vena cava.

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  • (PMID = 22470594.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303256
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3. Wen J, Li HZ, Ji ZG, Mao QZ, Shi BB, Yan WG: A decade of clinical experience with extra-adrenal paragangliomas of retroperitoneum: Report of 67 cases and a literature review. Urol Ann; 2010 Jan;2(1):12-6
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  • [Title] A decade of clinical experience with extra-adrenal paragangliomas of retroperitoneum: Report of 67 cases and a literature review.
  • OBJECT: The purpose was to highlight the diagnosis and treatment of extra-adrenal para-gangliomas, which often causes catecholamine hypersecretion and hypertension.
  • METHODS: 67 cases of extra-adrenal paraganglioma of retroperitoneum proven pathologically from 1999 to 2009 were reviewed and studied after operation.
  • There were nine cases assayed malignant paraganglioma by the follow-up.
  • CONCLUSIONS: 131-MIBG and octreotide have high sensitivity and accuracy in diagosing extra-adrenal paraganglioma.
  • Complete surgical excision is the treatment of choice for extra-adrenal paragangliomas as well as recurrent or metastatic disease, which could be resected laparoscopically.

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  • (PMID = 20842251.001).
  • [ISSN] 0974-7834
  • [Journal-full-title] Urology annals
  • [ISO-abbreviation] Urol Ann
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2934586
  • [Keywords] NOTNLM ; Extra-adrenal paraganglioma / diagnosis / retroperitoneal tumor / treatment
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4. Song HJ, Kim KM, Choi DI, Park CK: Carney triad in an adult with aggressive behavior: the first case in Korea. Yonsei Med J; 2009 Oct 31;50(5):709-12
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  • Carney triad is a rare syndrome of unknown etiology characterized by having at least two out of three following neoplasms: gastrointestinal stromal tumor, pulmonary chondroma and extra-adrenal paraganglioma.
  • We report a case of Carney triad in a 42-year-old woman presented with a gastrointestinal stromal tumor in the stomach and a malignant functioning paraganglioma in the retroperitoneum that was fatal five years after diagnosis.
  • The gastrointestinal stromal tumor was diagnosed as intermediate-risk of aggressive behavior and diffusely positive for c-kit whereas the retroperitoneal paraganglioma was negative for c-kit.
  • [MeSH-major] Carney Complex / chemically induced. Gastrointestinal Stromal Tumors / diagnosis. Paraganglioma / diagnosis. Retroperitoneal Neoplasms / diagnosis. Stomach Neoplasms / diagnosis

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  • [Cites] Am J Med Genet. 2002 Mar 1;108(2):132-9 [11857563.001]
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  • (PMID = 19881977.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2768248
  • [Keywords] NOTNLM ; Carney triad / gastrointestinal stromal tumor / malignant / paraganglioma
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5. Miesner T, Wilkie D, Gemensky-Metzler A, Weisbrode S, Colitz C: Extra-adrenal paraganglioma of the equine orbit: six cases. Vet Ophthalmol; 2009 Jul-Aug;12(4):263-8
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  • [Title] Extra-adrenal paraganglioma of the equine orbit: six cases.
  • At The Ohio State University from 1994-2006 six of seven horses evaluated for primary orbital disease were diagnosed with extra-adrenal paraganglioma (EAPG).
  • [MeSH-major] Eye Neoplasms / veterinary. Horse Diseases / pathology. Paraganglioma, Extra-Adrenal / veterinary

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  • (PMID = 19604344.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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6. Karagiannis A, Mikhailidis DP, Athyros VG, Harsoulis F: Pheochromocytoma: an update on genetics and management. Endocr Relat Cancer; 2007 Dec;14(4):935-56
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  • Pheochromocytomas (PHEOs) are rare neoplasms that produce catecholamines and usually arise from the adrenal medulla and are considered to be an adrenal paraganglioma (PGL).
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Adrenal Gland Neoplasms / therapy. Pheochromocytoma / genetics. Pheochromocytoma / therapy
  • [MeSH-minor] Adrenal Medulla / pathology. Adult. Age of Onset. Aged. Child. Chromogranin A / blood. Chromogranin A / genetics. Genetic Predisposition to Disease. Humans. Multiple Endocrine Neoplasia Type 2a / genetics. Paraganglioma / genetics. Prevalence

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  • (PMID = 18045948.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromogranin A
  • [Number-of-references] 194
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7. Tischler AS, Kimura N, Mcnicol AM: Pathology of pheochromocytoma and extra-adrenal paraganglioma. Ann N Y Acad Sci; 2006 Aug;1073:557-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathology of pheochromocytoma and extra-adrenal paraganglioma.
  • The 2004 WHO classification of endocrine tumors defines pheochromocytoma as a tumor arising from chromaffin cells in the adrenal medulla.
  • Closely related tumors in extra-adrenal sympathetic and parasympathetic paraganglia are classified as extra-adrenal paragangliomas.
  • A pheochromocytoma is an intra-adrenal sympathetic paraganglioma.
  • While arbitrary, this nomenclature serves to emphasize important distinctive properties of intra-adrenal tumors that must be taken into account in clinical practice and research.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Paraganglioma / pathology. Pheochromocytoma / pathology


8. Osaka K, Yokonishi T, Ito Y, Komiya A, Kobayashi K, Sakai N, Noguchi S, Kishi H, Tsuura Y: [A case of giant retroperitoneal paraganglioma]. Hinyokika Kiyo; 2010 Jul;56(7):377-80
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  • [Title] [A case of giant retroperitoneal paraganglioma].
  • Paraganglioma is a rare neuroendocrine tumor which arises from extra adrenal paraganglionic cells of the autonomic nervous system.
  • We report a case of a giant retroperitoneal paraganglioma.
  • The tumor, left kidney, adrenal gland and spleen were surgically resected.
  • Histological examination revealed extra-adrenal paraganglioma, and there was no invasion of the tumor to the left kidney, adrenal gland and spleen.
  • [MeSH-major] Paraganglioma / pathology. Retroperitoneal Neoplasms / pathology

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  • (PMID = 20724811.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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9. Qiao GB, Fang Y, Zeng WS, Peng LJ, Huang WJ: Images for diagnosis. An unusual case of Carney triad with high level catecholamine-secreting but no existence of extra-adrenal paraganglioma. Chin Med J (Engl); 2010 Feb 20;123(4):510-2
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  • [Title] Images for diagnosis. An unusual case of Carney triad with high level catecholamine-secreting but no existence of extra-adrenal paraganglioma.
  • [MeSH-major] Catecholamines / secretion. Lung Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 20193497.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Catecholamines
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10. Van Slycke S, Caiazzo R, Pigny P, Cardot-Bauters C, Arnalsteen L, D'Herbomez M, Leteurtre E, Rouaix-Emery N, Ernst O, Huglo D, Vantyghem MC, Wemeau JL, Carnaille B, Pattou F: Local-regional recurrence of sporadic or syndromic abdominal extra-adrenal paraganglioma: incidence, characteristics, and outcome. Surgery; 2009 Dec;146(6):986-92

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  • [Title] Local-regional recurrence of sporadic or syndromic abdominal extra-adrenal paraganglioma: incidence, characteristics, and outcome.
  • BACKGROUND: Operative excision of abdominal extra-adrenal paragangliomas (EAPs) does not preclude the late development of local-regional recurrence.
  • [MeSH-major] Neoplasm Recurrence, Local / etiology. Paraganglioma, Extra-Adrenal / etiology

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  • (PMID = 19958924.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / SDHC protein, human; 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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11. Ahmad S, Cathy D, Sheikh M, Sweeney P: Retroperitoneal extra-adrenal paraganglioma: a rare but important diagnosis. Ir J Med Sci; 2009 Jun;178(2):211-4

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  • [Title] Retroperitoneal extra-adrenal paraganglioma: a rare but important diagnosis.
  • BACKGROUND: Extra-adrenal paragangliomas of the retroperitonium are infrequently diagnosed.
  • AIM: We aim to describe a case report of an incidental finding of left retroperitoneal paraganglioma in a young man who presented with right flank pain.
  • CONCLUSION: Surgical resection is the only available curative option for extra-adrenal paragangliomas.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 18183473.001).
  • [ISSN] 1863-4362
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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12. Uchiyama S, Ikenaga N, Haruyama Y, Nagaike K, Hotokezaka M, Kai M, Tanaka H, Chijiiwa K: Asymptomatic extra-adrenal paraganglioma masquerading as retroperitoneal sarcoma. Clin J Gastroenterol; 2010 Feb;3(1):13-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic extra-adrenal paraganglioma masquerading as retroperitoneal sarcoma.
  • A low-density nodule was detected in the left adrenal gland, 10 mm in diameter.
  • Retroperitoneal sarcoma and nonfunctional left adrenal tumor were suspected, and surgical treatment was performed.
  • Blood pressure normalized after excision of the tumor; thus, a diagnosis of paraganglioma was favored over that of retroperitoneal sarcoma.
  • The left adrenal gland was resected together with the adrenal tumor.
  • Extra-adrenal retroperitoneal paraganglioma was considered, and the adrenal tumor was diagnosed as cortical adenoma.
  • In patients with retroperitoneal tumor, even in the absence of clinical symptoms, we should keep in mind the possibility of extra-adrenal paraganglioma.

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  • (PMID = 26189900.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Asymptomatic paraganglioma / Extra-adrenal paraganglioma / Retroperitoneal sarcoma / Retroperitoneal tumor
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13. Sawhney SA, Chapman AD, Carney JA, Gomersall LN, Dempsey OJ: Incomplete Carney triad--a review of two cases. QJM; 2009 Sep;102(9):649-53
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  • 'Carney's triad' characteristically includes multifocal pulmonary chondroma, gastric stromal sarcoma and extra-adrenal paraganglioma.
  • [MeSH-major] Chondroma / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Liver Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • (PMID = 19561114.001).
  • [ISSN] 1460-2393
  • [Journal-full-title] QJM : monthly journal of the Association of Physicians
  • [ISO-abbreviation] QJM
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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14. Tischler AS: Pheochromocytoma and extra-adrenal paraganglioma: updates. Arch Pathol Lab Med; 2008 Aug;132(8):1272-84
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  • [Title] Pheochromocytoma and extra-adrenal paraganglioma: updates.
  • CONTEXT: Advances in genetics and gene expression profiling have led to new ways of thinking about the pathobiology of pheochromocytoma and extra-adrenal paraganglioma.
  • CONCLUSIONS: The World Health Organization reserves the term pheochromocytoma for tumors arising from chromaffin cells in the adrenal medulla.
  • Closely related tumors in extra-adrenal sympathetic and parasympathetic paraganglia are classified as extra-adrenal paragangliomas.
  • A pheochromocytoma is an intra-adrenal sympathetic paraganglioma.
  • Although arbitrary, this nomenclature emphasizes important distinctive properties of intra-adrenal tumors, including an often adrenergic phenotype, relatively low rate of malignancy, and predilection to occur in particular hereditary syndromes.
  • The "10 percent rule" for pheochromocytoma/paraganglioma--10% familial, 10% malignant, 10% extra-adrenal--is therefore no longer tenable.
  • [MeSH-major] Adrenal Gland Neoplasms. Endocrinology / trends. Paraganglioma, Extra-Adrenal. Pheochromocytoma

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  • (PMID = 18684026.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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15. Ausania F, De-Giorgio F, Valerio L, Capelli A, Arena V: Neoplastic spread after trauma: natural death or manslaughter? Med Sci Law; 2010 Apr;50(2):100-2
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  • We report an unusual death of a seemingly healthy 26-year-old man due to diffuse metastasization of adrenal paraganglioma caused by rupture of the primitive tumour with subsequent massive haemorrhage after a relatively minor trauma.
  • [MeSH-major] Accidents / legislation & jurisprudence. Adrenal Gland Neoplasms / pathology. Paraganglioma / pathology. Wounds, Nonpenetrating / complications

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  • (PMID = 20593602.001).
  • [ISSN] 0025-8024
  • [Journal-full-title] Medicine, science, and the law
  • [ISO-abbreviation] Med Sci Law
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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16. Ghidirim G, Rojnoveanu G, Mishin I, Gutsu E, Iakovleva I: Extra-adrenal nonfunctional retroperitoneal paraganglioma: case report and review of the literature. Int Surg; 2005 Nov-Dec;90(5):275-8

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  • [Title] Extra-adrenal nonfunctional retroperitoneal paraganglioma: case report and review of the literature.
  • An extra-adrenal paraganglioma is a rare tumor derived from the chromaffin cells of sympathetic ganglia.
  • This report documents a rare case of nonfunctional extra-adrenal paraganglioma in a 20-year-old woman with persistent flank pain.
  • Tumor was successfully removed through a midline laparotomy incision, and pathological analysis of the surgical specimen revealed a paraganglioma.
  • This case emphasizes the necessity to include extra-adrenal paraganglioma in the differential diagnosis and management of retroperitoneal tumors, despite its rarity.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 16625946.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 14
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17. Albaroudi S, Ahallat M, Hosni K, Sabbah F, Hrora A, Rais M, Tounsi A: [Carney's triad: a new case]. Ann Chir; 2005 Oct;130(9):577-80
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  • Carney's triad is a very unusual syndrome, associating three different tumours on the same patient, a young woman generally: a gastric leiomyoblastoma, a pulmonary chondroma and an extra-adrenal paraganglioma.
  • The authors report through the literature review and a new case of Carney's syndrome associating gastric leiomyoblastoma and extra-adrenal paragangliomas, the different diagnostic and therapeutic criterias.
  • [MeSH-major] Chondroma / pathology. Leiomyoma, Epithelioid / pathology. Lung Neoplasms / pathology. Paraganglioma / pathology. Stomach Neoplasms / pathology

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  • (PMID = 16229813.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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18. Vogl TJ, Lehnert T, Wetter A, Mack MG, Wurster MG: Interventional radiology in Carney triad. Eur Radiol; 2005 Apr;15(4):833-7
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  • Interventional therapeutic methods are presented in Carney triad, which is a syndrome defined as the simultaneous presence of gastric leiomyosarcoma, extra-adrenal paraganglioma, and pulmonary chondroma.
  • [MeSH-minor] Adult. Chondroma / radiography. Chondroma / therapy. Female. Humans. Leiomyosarcoma / radiography. Leiomyosarcoma / therapy. Paraganglioma / radiography. Paraganglioma / therapy

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  • (PMID = 15108016.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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19. Rizzo SA, Newman SJ, Hecht S, Thomas WB: Malignant mediastinal extra-adrenal paraganglioma with spinal cord invasion in a dog. J Vet Diagn Invest; 2008 May;20(3):372-5
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  • [Title] Malignant mediastinal extra-adrenal paraganglioma with spinal cord invasion in a dog.
  • Immunohistochemistry and silver staining did not allow further differentiation of the tumor, and the diagnosis remains consistent with either a chromaffin paraganglioma or a nonchromaffin paraganglioma (chemodectoma) with some production of catecholamines.
  • Extra-adrenal paragangliomas are rare neoplasms in dogs but should be considered as a possible differential diagnosis for a primary paraspinal thoracic mass.
  • [MeSH-major] Dog Diseases / diagnosis. Paraganglioma / veterinary. Spinal Cord / pathology

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  • (PMID = 18460631.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Horenstein MG, Hitchcock TA, Tucker JA: Dual CD117 expression in gastrointestinal stromal tumor (GIST) and paraganglioma of Carney triad: a case report. Int J Surg Pathol; 2005 Jan;13(1):87-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dual CD117 expression in gastrointestinal stromal tumor (GIST) and paraganglioma of Carney triad: a case report.
  • We report a 36-year-old white woman with complete Carney triad, including metastatic gastric stromal tumor (GIST), pulmonary chondroma, and nonfunctioning extra-adrenal paraganglioma.
  • Immunohistochemistry was positive for CD34 and CD117 (c-kit) in the GIST, and positive for chromogranin and CD117 in the paraganglioma.
  • To our knowledge, this is the 21st complete Carney triad case reported and the first report of dual expression CD117 in both GIST and paraganglioma, a finding with intriguing pathogenetic implications related to the organization of the autonomic nervous system.
  • [MeSH-major] Chondroma / pathology. Gastrointestinal Stromal Tumors / pathology. Leiomyosarcoma / secondary. Lung Neoplasms / pathology. Paraganglioma, Extra-Adrenal / pathology. Proto-Oncogene Proteins c-kit / analysis

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  • (PMID = 15735861.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chromogranins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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21. Pagni F, Galbiati E, Bono F, Di Bella C: Renal hilus paraganglioma: a case report and brief review. Pathologica; 2009 Apr;101(2):89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal hilus paraganglioma: a case report and brief review.
  • Paraganglioma is a rare tumour that originates from any paraganglia.
  • Among extra-adrenal paraganglioma, renal hilus is a rare location.
  • The final diagnosis was renal hilus paraganglioma.
  • The paper shows the difficulty in diagnostic approaches to paraganglioma in this atypical site.
  • [MeSH-major] Kidney Neoplasms / pathology. Paraganglioma, Extra-Adrenal / pathology

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  • (PMID = 19886555.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Svajdler Mm, Bohus P, Závacký P, Vol'anská M, Repovský A, Juskanicová E: Paraganglioma of the mesenterium: a case report. Cesk Patol; 2007 Oct;43(4):153-6
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  • [Title] Paraganglioma of the mesenterium: a case report.
  • Extra-adrenal paragangliomas constitute 10 % or less of phaeochromocytomas/paragangliomas.
  • We report a case of extra-adrenal paraganglioma occurring in the small intestine mesentery in a 65-year-old man.
  • To our knowledge, there are only seven case reports of paraganglioma occurring in this non-typical site.
  • Although rare, paraganglioma should be included in the preoperative differential diagnosis of solid mesenteric tumours, to prevent any potential life-threatening event peroperatively in the case of a catecholamines-producing tumour.
  • [MeSH-major] Mesentery. Paraganglioma / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 18188923.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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23. Havekes B, Corssmit EP, Jansen JC, van der Mey AG, Vriends AH, Romijn JA: Malignant paragangliomas associated with mutations in the succinate dehydrogenase D gene. J Clin Endocrinol Metab; 2007 Apr;92(4):1245-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Metastasis and/or local tumor invasion was documented 0 (n=2), 1, 18, and 30 yr after the initial diagnosis of paraganglioma.
  • Malignancy was proven by paraganglioma bone metastases (n=2), intrathoracic paraganglioma with lymph node metastases, locally invasive head-and-neck paraganglioma with destruction of the petrosal bone, and locally invasive paraganglioma of the bladder with lymph node metastases.
  • Four of the five patients developed catecholamine excess during follow-up due to intraadrenal paraganglioma (pheochromocytoma) (n=1), extra adrenal paraganglioma (n=2), and presumed subclinical disease (n=1).
  • [MeSH-major] Iron-Sulfur Proteins / genetics. Mutation. Paraganglioma / genetics. Succinate Dehydrogenase / genetics
  • [MeSH-minor] Adrenal Gland Neoplasms / genetics. Adult. Aged. Amino Acid Substitution. Carotid Body Tumor / genetics. Female. Humans. Male. Middle Aged. Skull Neoplasms / genetics. Temporomandibular Joint

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  • (PMID = 17227803.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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24. Agaimy A, Hartmann A: [Hereditary and non-hereditary syndromic gastointestinal stromal tumours]. Pathologe; 2010 Oct;31(6):430-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In decreasing order of frequency, neurofibromatosis Recklinghausen (NF-1), Carney triad (gastric GIST, pulmonary chondroma and extra-adrenal paraganglioma), familial GIST syndromes resulting from germline mutations in c-Kit/PDGFRA and the Carney-Stratakis syndrome (hereditary GIST paraganglioma syndrome caused by germline mutations in the mitochondrial tumour suppressor gene pathway involving the succinate dehydrogenase subunits SDHD, SDHC and SDHB) represent the four most important GIST syndromes characterized to date.

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  • (PMID = 20848108.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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25. Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K, North American Neuroendocrine Tumor Society (NANETS): The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas; 2010 Aug;39(6):775-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer.
  • Pheochromocytomas, intra-adrenal paraganglioma, and extra-adrenal sympathetic and parasympathetic paragangliomas are neuroendocrine tumors derived from adrenal chromaffin cells or similar cells in extra-adrenal sympathetic and parasympathetic paraganglia, respectively.
  • [MeSH-minor] Humans. Paraganglioma / diagnosis. Paraganglioma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / therapy

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  • (PMID = 20664475.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA167632; United States / Intramural NIH HHS / / ZIA HD008735-11
  • [Publication-type] Consensus Development Conference, NIH; Journal Article; Practice Guideline
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS395864; NLM/ PMC3419007
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26. Unlü Y, Becit N, Ceviz M, Koçak H: Management of carotid body tumors and familial paragangliomas: review of 30 years' experience. Ann Vasc Surg; 2009 Sep-Oct;23(5):616-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Carotid body tumors (CBTs), especially familial paragangliomas, are rare benign neoplasms, accounting for <0.5% of all tumors; and they are the most common extra-adrenal paraganglioma.
  • Two of the 28 patients with CBTs had a familial paraganglioma history of CBT.
  • [MeSH-major] Carotid Body Tumor / surgery. Paraganglioma, Extra-Adrenal / surgery. Vascular Surgical Procedures

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  • (PMID = 19747612.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Georgiadis GS, Lazarides MK, Tsalkidis A, Argyropoulou P, Giatromanolaki A: Carotid body tumor in a 13-year-old child: Case report and review of the literature. J Vasc Surg; 2008 Apr;47(4):874-880
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Carotid body tumor (CBT), an extra-adrenal paraganglioma, represents an uncommon entity arising in chemoreceptor tissue located at the carotid bifurcation.
  • We report an unusual case of a large (50 x 43 x 30 mm) carotid paraganglioma of Shamblin type III in a 13-year-old female, living at high altitude until the age of 9 years.

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  • (PMID = 18280094.001).
  • [ISSN] 0741-5214
  • [Journal-full-title] Journal of vascular surgery
  • [ISO-abbreviation] J. Vasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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28. Zhang L, Smyrk TC, Young WF Jr, Stratakis CA, Carney JA: Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. Am J Surg Pathol; 2010 Jan;34(1):53-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Carney triad, as originally described in 1977, was the association of 3 tumors: gastric epithelioid leiomyosarcoma [later renamed gastrointestinal stromal tumor (GIST)], extra-adrenal paraganglioma, and pulmonary chondroma.

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  • (PMID = 19935059.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA HD008920-01
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS460457; NLM/ PMC3652406
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29. van Houtum WH, Corssmit EP, Douwes Dekker PB, Jansen JC, van der Mey AG, Bröcker-Vriends AH, Taschner PE, Losekoot M, Frölich M, Stokkel MP, Cornelisse CJ, Romijn JA: Increased prevalence of catecholamine excess and phaeochromocytomas in a well-defined Dutch population with SDHD-linked head and neck paragangliomas. Eur J Endocrinol; 2005 Jan;152(1):87-94
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  • One of the nine patients had an extra-adrenal paraganglioma.

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  • (PMID = 15762191.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Catecholamines; 0 / DNA, Neoplasm; 0 / Imidazoles; 0 / Membrane Proteins; 0 / SDHD protein, human; EC 1.3.99.1 / Succinate Dehydrogenase; KVL61ZF9UO / neticonazole
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30. Agaimy A, Pelz AF, Corless CL, Wünsch PH, Heinrich MC, Hofstaedter F, Dietmaier W, Blanke CD, Wieacker P, Roessner A, Hartmann A, Schneider-Stock R: Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridization. Oncol Rep; 2007 Jul;18(1):9-15
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  • Carney triad is a rare non-hereditary condition affecting young females and characterized by metachronous or synchronous occurrence of epithelioid gastrointestinal stromal tumours (GISTs), pulmonary chondroma and extra-adrenal paraganglioma.
  • Two patients had GISTs and pulmonary chondroma and one had GISTs and paraganglioma.
  • Initial manifestation was GIST (n=1), pulmonary chondroma (n=1) and bladder paraganglioma (n=1).
  • [MeSH-major] Chondroma / genetics. Gastrointestinal Stromal Tumors / genetics. Lung Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Paraganglioma, Extra-Adrenal / genetics. Pyloric Antrum / pathology. Stomach Neoplasms / genetics

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  • (PMID = 17549339.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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31. Chen CF, Chuang CH, Liu MK, Hsu WH, Lin HJ, Hsieh JS: Clinical, radiologic and pathologic characteristics of the Carney triad: a case report and literature review. Kaohsiung J Med Sci; 2010 Aug;26(8):428-34
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  • This report describes a patient with a gastrointestinal stromal tumor (GIST) and upper gastrointestinal hemorrhage as initial presentations of the Carney triad, a synchronous or metachronous condition involving gastric leiomyosarcoma, extra-adrenal paraganglioma and pulmonary chondroma.
  • The gastric GIST with liver metastasis and retroperitoneal paraganglioma were confirmed by pathologic study.
  • [MeSH-major] Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / radiography. Paraganglioma, Extra-Adrenal / pathology. Paraganglioma, Extra-Adrenal / radiography

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20705254.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
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32. Powers JF, Picard KL, Tischler AS: RET expression and neuron-like differentiation of pheochromocytoma and normal chromaffin cells. Horm Metab Res; 2009 Sep;41(9):710-4
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  • In this investigation, cultured cells from two normal human adrenal medullas, two of three human pheochromocytomas, and one extra-adrenal paraganglioma showed RET induction corresponding with extensive nerve growth factor-induced outgrowth of neurite-like processes, while one pheochromocytoma showed neither processes nor RET induction.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Chromaffin Cells / metabolism. Gene Expression. Neurogenesis. Neurons / metabolism. Pheochromocytoma / genetics. Proto-Oncogene Proteins c-ret / genetics

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  • (PMID = 19551609.001).
  • [ISSN] 1439-4286
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA48017; United States / NINDS NIH HHS / NS / NS37685
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret
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33. Fiebrich H, Brouwers AH, Kerstens MN, Pijl ME, Kema IP, de Jong JR, van der Wal JE, Sluiter WJ, de Vries EG, Links TP: Sensitivity of 6-[F-18]fluoro-L-dihydroxyphenylalanine positron emission tomography for localizing tumors causing catecholamine excess. J Clin Oncol; 2009 May 20;27(15_suppl):11064

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  • The tumor localization was found in 45 patients, 43 with <sup>18</sup>F-DOPA PET, 31 with <sup>123</sup>I-MIBG and 32 with CT/MRI, resulting with surgery in final diagnosis of pheochromocytoma in 40, adrenal hyperplasia in 2, paraganglioma in 2, ganglioneuroma in 1 and 3 unknown (as yet no lesion detected).

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  • (PMID = 27963142.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Torres-Carranza E, Infante-Cossío P, García-Perla A, Belmonte R, Menéndez J, Gutiérrez-Pérez JL: [Paraganglioma of the vagus nerve]. Neurocirugia (Astur); 2006 Jun;17(3):255-60

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  • [Title] [Paraganglioma of the vagus nerve].
  • [Transliterated title] Paraganglioma del nervio vago.
  • In this paper we describe a new case of paraganglioma of the vagus nerve in a cervical location, with hypertensive episodes and high catecholamine-levels.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / diagnosis. Vagus Nerve / pathology. Vagus Nerve Diseases / diagnosis

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  • (PMID = 16855784.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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35. Nakamura F, Silva RA, dos Santos VP, Razuk Filho A, Caffaro RA: [Preoperative embolization of abdominal paraganglioma: case report]. Rev Col Bras Cir; 2010 Apr;37(2):159-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Preoperative embolization of abdominal paraganglioma: case report].
  • [Transliterated title] Embolização pré operatória no tratamento de paraganglioma abdominal: relato de caso.
  • Paragangliomas is a pheochromocytoma of extra adrenal localization.
  • The case report is a male, 55 years old who presented symptoms of adrenergic hyperstimulation associated to an abdominal mass diagnosed as paraganglioma by a biopsy.
  • [MeSH-major] Abdominal Neoplasms / therapy. Embolization, Therapeutic. Paraganglioma / therapy

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  • (PMID = 20549108.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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36. Villas Boas O, Bastos AM, Ramiro AC, Fonseca RA: [Serous retinal detachment in paraganglioma: case report]. Arq Bras Oftalmol; 2008 Jan-Feb;71(1):104-6
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  • [Title] [Serous retinal detachment in paraganglioma: case report].
  • [Transliterated title] Descolamento de retina seroso em paraganglioma: relato de caso.
  • It was confirmed to be a paraganglioma by anatomicopathological examination.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Pheochromocytoma / complications. Pregnancy Complications, Neoplastic. Retinal Detachment / etiology

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  • (PMID = 18408849.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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37. Lapinski JE, Chen L, Zhou M: Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: utility of immunohistochemical markers. Appl Immunohistochem Mol Morphol; 2010 Oct;18(5):414-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: utility of immunohistochemical markers.
  • AE1/3 and epithelial membrane antigen were negative in all adrenocortical lesions and paraganglioma cases, whereas CAM5.2 was positive in 78.9% of adrenocortical lesions and 6.7% of paragangliomas.
  • Calretinin and Melan-A were positive in 100% and 94.7% of adrenal, 0% and 14.3% of CCRCC, and 26.7% and 26.7% of paragangliomas.


38. Zorlu F, Selek U, Ulger S, Donmez T, Erden E: Paraganglioma in sella. J Neurooncol; 2005 Jul;73(3):265-7
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  • [Title] Paraganglioma in sella.
  • We report a very rare case of a paraganglioma arising from sellar and suprasellar region which has been treated with radiotherapy following multiple surgeries.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / pathology. Pituitary Neoplasms / pathology. Sella Turcica / pathology

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  • (PMID = 15980978.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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39. Lee JA, Duh QY: Sporadic paraganglioma. World J Surg; 2008 May;32(5):683-7
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  • [Title] Sporadic paraganglioma.
  • Paraganglioma are rare chromaffin cell tumors that develop from the neural crest cells.
  • Those grow within the adrenal medulla and are known as pheochromocytoma.
  • Other sympathetic paragangliomas are also known as extra-adrenal pheochromocytomas.
  • They arise outside of the adrenal gland and can be found anywhere along the sympathetic chain from the base of the skull and neck (5% of cases) to the bladder and prostate gland (10%).
  • We use the term paraganglioma to refer to extra-adrenal tumors and pheochromocytoma to refer to intra-adrenal tumors.
  • Medical management of catecholamine-secreting paraganglioma is the same as for pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / therapy. Paraganglioma / diagnosis. Paraganglioma / therapy

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  • (PMID = 18224469.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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40. Boulogianni G, Chourmouzi D, Sivitanidis E, Drevelegas AK: An incidental nonfunctioning mediastinal paraganglioma (2009: 11b). Aorticosympathetic paraganglioma. Eur Radiol; 2010 Feb;20(2):506-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An incidental nonfunctioning mediastinal paraganglioma (2009: 11b). Aorticosympathetic paraganglioma.
  • A rare case of an incidental nonfunctioning mediastinal paraganglioma is presented.
  • The diagnosis of aorticosympathetic paraganglioma was established by histological examination after surgical removal of the tumor.
  • [MeSH-major] Mediastinal Neoplasms / diagnostic imaging. Paraganglioma, Extra-Adrenal / diagnostic imaging

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  • (PMID = 20119731.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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41. Bhatt S, Vanderlinde S, Farag R, Dogra VS: Pararectal paraganglioma. Br J Radiol; 2007 Oct;80(958):e253-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pararectal paraganglioma.
  • Paragangliomas are neoplasms that arise from neural crest cells and histologically resemble their adrenal counterpart, the phaeochromocytoma.
  • The majority of extra-adrenal tumours develop within the abdomen and are associated with the coeliac, superior and inferior mesenteric ganglia, which run parallel to the aorta.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 17959918.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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42. Işik AC, Erem C, Imamoğlu M, Cinel A, Sari A, Maral G: Familial paraganglioma. Eur Arch Otorhinolaryngol; 2006 Jan;263(1):23-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Familial paraganglioma.
  • The carotid body paraganglioma (CBPG) and glomus vagale manifested as asymptomatic neck masses.
  • [MeSH-major] Head and Neck Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Paraganglioma, Extra-Adrenal / genetics
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / genetics. Adult. Carotid Body Tumor / diagnosis. Carotid Body Tumor / genetics. Female. Glomus Jugulare Tumor / diagnosis. Glomus Jugulare Tumor / genetics. Humans. Male. Middle Aged. Pedigree. Pheochromocytoma / diagnosis. Pheochromocytoma / genetics

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  • [Cites] Ann Vasc Surg. 2002 May;16(3):331-8 [11957009.001]
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  • (PMID = 16320027.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. Nozaki T, Iida H, Tsuritani S, Okumura A, Komiya A, Fuse H: Laparoscopic resection of retrocaval paraganglioma. J Laparoendosc Adv Surg Tech A; 2010 May;20(4):363-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic resection of retrocaval paraganglioma.
  • OBJECTIVES: Definitive treatment of paraganglioma is by surgical resection.
  • Laparoscopic resection of the paraganglioma presents a unique surgical challenge due to inherent risks associated with excessive catecholamine release during surgical manipulation and variable anatomic presentation.
  • In this report, we present our experience with the laparoscopic resection of the retrocaval paraganglioma.
  • METHODS: Between October 2001 and November 2007, 2 patients underwent the laparoscopic resection of a retrocaval paraganglioma.
  • Finally, the tumor and the right adrenal gland were extracted in an endobag.
  • CONCLUSIONS: To our knowledge, this is the first report of the laparoscopic resection of a retrocaval paraganglioma.
  • For the resection of a paraganglioma, in this location, laparoscopy has the advantage of precise visualization, which helps to resect the tumor completely.
  • Laparoscopic resection of a paraganglioma, despite the high level of compression of the IVC, is a feasible, reproducible technique with appropriate preoperative planning.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Laparoscopy. Paraganglioma / pathology. Paraganglioma / surgery

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  • (PMID = 20438308.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Chetty R: Familial paraganglioma syndromes. J Clin Pathol; 2010 Jun;63(6):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Familial paraganglioma syndromes.
  • The familial paraganglioma-phaeochromocytoma syndromes are less well recognised, but as more genetic testing is performed, more cases belonging to this syndrome will be revealed.
  • Patients with SDHB mutations have a positive family history in 33% of cases, present with single tumours around 30 years of age and have extra-adrenal paragangliomas mainly in the abdomen and pelvis; 20% may also have phaeochromocytomas, and tumours in these patients have a great propensity to metastasise.
  • [MeSH-major] Neoplastic Syndromes, Hereditary / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics

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  • (PMID = 20498024.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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45. Gong J, Wang X, Chen X, Chen N, Huang R, Lu C, Chen D, Zeng H, Zhou Q: Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases. Urol Int; 2010;85(3):368-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases.
  • Adrenal composite pheochromocytoma is rare, most of which is functional, and extra-adrenal composite paraganglioma is extremely rare.
  • We describe and compare the clinicopathological and immunohistochemical features of a retroperitoneal extra-adrenal composite paraganglioma and an adrenal composite pheochromocytoma.
  • Both tumors were composed of typical paraganglioma/pheochromocytoma closely admixed with ganglioneuroma component.
  • In addition to typical immunohistochemical phenotypes characteristic of each component, both tumors showed focal staining of somatostatin, and the adrenal tumor was also regionally positive for insulin and prolactin.
  • These tumors serve to exemplify the extremely rare occurrences of clinically silent, nonfunctioning composite pheochromocytoma or paraganglioma with aberrant expression of hormones.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Immunohistochemistry / methods. Paraganglioma / pathology. Pheochromocytoma / pathology
  • [MeSH-minor] Adrenal Glands / pathology. Adrenal Glands / radiography. Adult. Chromaffin Cells / pathology. Ganglioneuroma / diagnosis. Ganglioneuroma / pathology. Humans. Male. Middle Aged. Phenotype. Tomography, X-Ray Computed / methods

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20829582.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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46. Kantorovich V, Pacak K: Pheochromocytoma and paraganglioma. Prog Brain Res; 2010;182:343-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pheochromocytoma and paraganglioma.
  • [MeSH-major] Adrenal Gland Neoplasms. Paraganglioma. Pheochromocytoma

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20541673.001).
  • [ISSN] 1875-7855
  • [Journal-full-title] Progress in brain research
  • [ISO-abbreviation] Prog. Brain Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HD008735-08
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Radiopharmaceuticals
  • [Other-IDs] NLM/ NIHMS750176; NLM/ PMC4714594
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47. Ramos R, Moya J, Villalonga R, Morera R, Ferrer G: Mediastinal aortosympathetic paraganglioma: report of two cases. Asian Cardiovasc Thorac Ann; 2007 Aug;15(4):e49-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal aortosympathetic paraganglioma: report of two cases.
  • Thoracic paragangliomas or extra-adrenal pheochromocytomas are uncommon neoplasms that may arise from the extra-adrenal paraganglia.
  • We present two cases of posterior mediastinum paraganglioma.
  • The diagnosis of aorticosympathectic paraganglioma was established by histologic examination.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Paraganglioma, Extra-Adrenal / pathology

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  • (PMID = 17664194.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Chiang KH, Liou JY, Shyu KG, Yeh CH, Wu CC, Chen TJ, Lo HM: Hypertension due to co-existing paraganglioma and unilateral adrenal cortical hyperplasia. J Formos Med Assoc; 2007 Dec;106(12):1043-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypertension due to co-existing paraganglioma and unilateral adrenal cortical hyperplasia.
  • A rare case of combined unilateral adrenal hyperplasia and paraganglioma is reported.
  • Computed tomography showed a microadenoma of the left adrenal gland and a well demarcated left retroperitoneal para-aortic mass.
  • Adrenal vein sampling for aldosterone and renin levels suggested left adrenal lesion.
  • Surgical removal of the left adrenal gland and para-aortic mass was performed.
  • Pathologic examination of the resected left adrenal gland showed adrenal cortical hyperplasia and the left retroperitoneal para-aortic mass showed a paraganglioma.

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  • (PMID = 18194911.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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49. Kavakli K, Ozturk M, Ongoru O, Gürkök S, Genc O: Primary pulmonary paraganglioma with Hodgkin's lymphoma. Thorac Cardiovasc Surg; 2009 Sep;57(6):375-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pulmonary paraganglioma with Hodgkin's lymphoma.
  • Extra-adrenal paragangliomas are uncommon tumors arising from neuroectodermal-derived paraganglionic tissue.
  • There are very few case reports on primary pulmonary paraganglioma in the literature.
  • Subsequent bronchoscopic biopsy showed paraganglioma and the patient underwent a left lower lobectomy.
  • [MeSH-major] Hodgkin Disease / diagnosis. Lung Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • [Copyright] Georg Thieme Verlag KG Stuttgart New York.
  • (PMID = 19707986.001).
  • [ISSN] 1439-1902
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 7
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50. Ozüm U, Eğilmez R, Yildirim A: Paraganglioma in pituitary fossa. Neuropathology; 2008 Oct;28(5):547-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraganglioma in pituitary fossa.
  • We present a case of sellar paraganglioma with parasellar and suprasellar extension in a 70-year-old man who presented with headache.
  • Histopathological diagnosis was paraganglioma.
  • Differential diagnosis between paragangliomas and unusual types of pituitary adenomas, especially null-cell adenomas, is made by presence of cell nests (Zellballen) in paraganglioma, lack of immunopositivity for pituitary hormones, cytoplasmic immunopositivity for chromogranin A and neuron-specific enolase, and immunonegativity for cytokeratin 19, cytokeratin 20 and endomysial antibody.
  • In the case of a mass in the sellar region, paraganglioma, although rare, should be included in the differential diagnosis.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 18410271.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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51. Kshirsagar AY, Dombale VD, Vinchurkar KM, Pareek VA: Retroperitoneal para-aortic paraganglioma. Int Surg; 2005 Jul-Aug;90(3):141-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal para-aortic paraganglioma.
  • Paragangliomas or chemodectomas are neoplasms that arise from neural crest cells and histologically resemble their adrenal counterpart, the pheochromocytoma.
  • Seventy-one percent of the extra-adrenal paragangliomas are located in the superior or inferior paraaortic area.
  • [MeSH-major] Para-Aortic Bodies. Paraganglioma, Extra-Adrenal / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16466001.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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52. Santovito D, Conforti M, Varetto G, Rispoli P: Paraganglioma of the hypoglossal nerve. J Vasc Surg; 2009 Apr;49(4):1053-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraganglioma of the hypoglossal nerve.
  • After the incidental intraoperative discovery of a paraganglioma of cranial nerve XII, we searched our hospital database and literature for similar cases to determine whether evidence exists to support the existence of paraganglioma of the hypoglossal nerve.
  • We describe a case of cranial nerve XII paraganglioma, recognized only during surgery, without any indicative preoperative sign or symptom nor diagnostic imaging studies.
  • In light of published findings, only four cases described since 1966, and our experience, the report discusses diagnostic criteria that could aid in establishing a diagnosis of hypoglossal nerve paraganglioma based on a reasonable degree of medical certainty.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Hypoglossal Nerve Diseases / pathology. Incidental Findings. Paraganglioma, Extra-Adrenal / pathology

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  • (PMID = 19341894.001).
  • [ISSN] 1097-6809
  • [Journal-full-title] Journal of vascular surgery
  • [ISO-abbreviation] J. Vasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Tuncel A, Aslan Y, Han O, Horasanli E, Seckin S, Atan A: Laparoscopic resection of periadrenal paraganglioma mimicking an isolated adrenal hydatid cyst. JSLS; 2010 Oct-Dec;14(4):579-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic resection of periadrenal paraganglioma mimicking an isolated adrenal hydatid cyst.
  • We present the case of a 64-year-old female with a periadrenal paraganglioma.
  • These findings made us think it was an isolated adrenal hydatid cyst.
  • Histopathological examination was consistent with periadrenal paraganglioma.
  • We believe that the paraganglioma can mimic the radiological appearance of an isolated adrenal hydatid cyst, which should be taken into consideration during diagnosis.

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  • (PMID = 21605527.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3083054
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54. Kshirsagar AY, Dombale VD, Vinchurkar KM, Pareek VA: Retroperitoneal para-aortic paraganglioma. Int Surg; 2006 Jan-Feb;91(1):33-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal para-aortic paraganglioma.
  • Paragangliomas or chemodectomas are neoplasms that arise from neural crest cells and histologically resemble their adrenal counterpart, the pheochromocytoma.
  • Seventy-one percent of the extra-adrenal paragangliomas are located in the superior or inferior para-aortic area.
  • [MeSH-major] Paraganglioma / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16706100.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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55. Herbach N, Breuer W, Hermanns W: Metastatic extra-adrenal sympathetic paraganglioma in a horse. J Comp Pathol; 2010 Aug-Oct;143(2-3):199-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic extra-adrenal sympathetic paraganglioma in a horse.
  • The findings were consistent with a metastatic extra-adrenal sympathetic paraganglioma.
  • [MeSH-major] Autonomic Nervous System Diseases / veterinary. Horse Diseases / pathology. Paraganglioma, Extra-Adrenal / veterinary. Peritoneal Neoplasms / veterinary. Thyroid Neoplasms / veterinary

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20153870.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Nuclear Proteins; 0 / Synaptophysin
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56. Miraldi F, Taffon C, Toscano M, Barretta A: Black cardiac paraganglioma in a multiple paraganglioma syndrome. Eur J Cardiothorac Surg; 2007 Dec;32(6):940-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Black cardiac paraganglioma in a multiple paraganglioma syndrome.
  • We describe a unique case of a patient with a 'pigmented' cardiac paraganglioma in a multiple paraganglioma syndrome.
  • The histological findings were paraganglioma with abundant, dark granular pigment.
  • [MeSH-major] Heart Neoplasms / diagnosis. Hyperpigmentation / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • [CommentIn] Eur J Cardiothorac Surg. 2009 Jan;35(1):189 [19027316.001]
  • (PMID = 17900919.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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57. Nakamura E, Kaelin WG Jr: Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma. Endocr Pathol; 2006;17(2):97-106
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma.
  • This review focuses on the genetics of these tumors and suggests a possible link between familial pheochromocytomas/paraganglioma genes and control of neuronal apoptosis during embryological development.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Fetal Development / physiology. Genetic Predisposition to Disease. Paraganglioma / genetics. Pheochromocytoma / genetics

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  • (PMID = 17159241.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 9061-61-4 / Nerve Growth Factor; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Number-of-references] 63
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58. Varma K, Jain S, Mandal S: Cytomorphologic spectrum in paraganglioma. Acta Cytol; 2008 Sep-Oct;52(5):549-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphologic spectrum in paraganglioma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Head and Neck Neoplasms / pathology. Mediastinal Neoplasms / pathology. Paraganglioma / pathology. Retroperitoneal Neoplasms / pathology

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  • (PMID = 18833816.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Daramola OO, Shinners MJ, Levine SC: Secreting jugulotympanic paraganglioma with venous involvement into the thorax. Laryngoscope; 2008 Jul;118(7):1233-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secreting jugulotympanic paraganglioma with venous involvement into the thorax.
  • Paragangliomas are highly vascular tumors that arise from chief cells in extra-adrenal paraganglia of the autonomic nervous system.
  • Patients with refractory hypertension and masses suspicious for paraganglioma should be examined for functional tumors.

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  • (PMID = 18425050.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] X4W3ENH1CV / Norepinephrine
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60. Yamaguchi T, Tada M, Takahashi H, Kagawa R, Takeda R, Sakata S, Yamamoto M, Nishizaki D: An incidentally discovered small and asymptomatic para-aortic paraganglioma. Eur Surg Res; 2008;40(1):14-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [Title] An incidentally discovered small and asymptomatic para-aortic paraganglioma.
  • Preoperative diagnosis of asymptomatic paraganglioma is difficult due to the lack of specific symptoms.
  • In this report, we present a rare case of a small and asymptomatic para-aortic paraganglioma.
  • Under these findings, the diagnosis of para-aortic paraganglioma was determined.
  • [MeSH-major] Para-Aortic Bodies / pathology. Paraganglioma, Extra-Adrenal / pathology. Paraganglioma, Extra-Adrenal / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 17717420.001).
  • [ISSN] 1421-9921
  • [Journal-full-title] European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
  • [ISO-abbreviation] Eur Surg Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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61. Gedik GK, Hoefnagel CA, Bais E, Olmos RA: 131I-MIBG therapy in metastatic phaeochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging; 2008 Apr;35(4):725-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 131I-MIBG therapy in metastatic phaeochromocytoma and paraganglioma.
  • We report our experience for the treatment of malignant phaeochromocytoma and paraganglioma.
  • MATERIALS AND METHODS: The charts of 19 patients with malignant phaeochromocytoma (n = 12) or paraganglioma (n = 7), who were treated with (131)I-MIBG, were retrospectively reviewed.
  • CONCLUSION: Our data support that symptomatic and biochemical response can be reached with (131)I-MIBG therapy in patients with metastatic phaeochromocytoma and paraganglioma.
  • [MeSH-major] 3-Iodobenzylguanidine / therapeutic use. Adrenal Gland Neoplasms / radiotherapy. Antineoplastic Agents / therapeutic use. Paraganglioma / radiotherapy. Pheochromocytoma / radiotherapy

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  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
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62. Amar L, Bertherat J, Baudin E, Ajzenberg C, Bressac-de Paillerets B, Chabre O, Chamontin B, Delemer B, Giraud S, Murat A, Niccoli-Sire P, Richard S, Rohmer V, Sadoul JL, Strompf L, Schlumberger M, Bertagna X, Plouin PF, Jeunemaitre X, Gimenez-Roqueplo AP: Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol; 2005 Dec 1;23(34):8812-8
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic testing in pheochromocytoma or functional paraganglioma.
  • PURPOSE: To assess the yield and the clinical value of systematic screening of susceptibility genes for patients with pheochromocytoma (pheo) or functional paraganglioma (pgl).
  • Mutation carriers were younger and more frequently had bilateral or extra-adrenal tumors.
  • In patients with an SDHB mutation, the tumors were larger, more frequently extra-adrenal, and malignant.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genetic Testing / methods. Pheochromocytoma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Algorithms. Child. Female. France. Gene Frequency. Genetic Predisposition to Disease / genetics. Genotype. Germ-Line Mutation / genetics. Humans. Iron-Sulfur Proteins / genetics. Male. Membrane Proteins / genetics. Middle Aged. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Paraganglioma / diagnosis. Paraganglioma / genetics. Phenotype. Protein Subunits / genetics. Proto-Oncogene Proteins c-ret / genetics. Succinate Dehydrogenase / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 16314641.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins; 0 / Membrane Proteins; 0 / Protein Subunits; 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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63. Fliedner SM, Lehnert H, Pacak K: Metastatic paraganglioma. Semin Oncol; 2010 Dec;37(6):627-37

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic paraganglioma.
  • Paragangliomas (PGLs) are chromaffin cell tumors arising from ganglia; when arising in the adrenal gland they are called pheochromocytomas.
  • In recent years the opinion that metastatic disease is rare in PGL had to be revised, particularly in patients presenting with extra-adrenal PGL, with PGLs exceeding 5 cm in diameter, and/or those carrying an SDHB germline mutation.
  • [MeSH-major] Paraganglioma / secondary

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  • [Copyright] Published by Elsevier Inc.
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  • (PMID = 21167381.001).
  • [ISSN] 1532-8708
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HD008735-07
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transcription Factors; 0 / snail family transcription factors; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Other-IDs] NLM/ NIHMS252333; NLM/ PMC3018803
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64. Cascón A, Pita G, Burnichon N, Landa I, López-Jiménez E, Montero-Conde C, Leskelä S, Leandro-García LJ, Letón R, Rodríguez-Antona C, Díaz JA, López-Vidriero E, González-Neira A, Velasco A, Matias-Guiu X, Gimenez-Roqueplo AP, Robledo M: Genetics of pheochromocytoma and paraganglioma in Spanish patients. J Clin Endocrinol Metab; 2009 May;94(5):1701-5
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetics of pheochromocytoma and paraganglioma in Spanish patients.
  • CONTEXT: The presence of familial history in pheochromocytoma/paraganglioma patients, including syndromic antecedents, leads in the majority of cases to a positive genetic testing for mutations in one of the major susceptibility genes described so far.
  • [MeSH-major] Adrenal Gland Neoplasms / epidemiology. Adrenal Gland Neoplasms / genetics. Paraganglioma / epidemiology. Paraganglioma / genetics. Pheochromocytoma / epidemiology. Pheochromocytoma / genetics

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  • (PMID = 19258401.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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65. Yendamuri S, Elfar M, Walkes JC, Reardon MJ: Aortic paraganglioma requiring resection and replacement of the aortic root. Interact Cardiovasc Thorac Surg; 2007 Dec;6(6):830-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aortic paraganglioma requiring resection and replacement of the aortic root.
  • This case report demonstrates the resection of an aortic root paraganglioma incidentally discovered in a 32-year-old male with replacement of the root for an oncologically complete resection.
  • [MeSH-major] Aorta / transplantation. Aortic Bodies / surgery. Blood Vessel Prosthesis. Blood Vessel Prosthesis Implantation. Incidental Findings. Paraganglioma, Extra-Adrenal / surgery. Vascular Neoplasms / surgery

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  • (PMID = 17901107.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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66. Hawari M, Yousri T, Hawari R, Tsang G: Intrapericardial paraganglioma directly irrigated by the right coronary artery. J Card Surg; 2008 Nov-Dec;23(6):780-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrapericardial paraganglioma directly irrigated by the right coronary artery.
  • We present a case of a nonfunctioning intrapericardial paraganglioma that presented as a typical chest pain in a 51-year-old woman.
  • Histopathological examination of the mass was characteristic of a paraganglioma.
  • [MeSH-major] Coronary Vessels / pathology. Heart Neoplasms / blood supply. Heart Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / blood supply. Paraganglioma, Extra-Adrenal / diagnosis. Pericardium / pathology

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  • (PMID = 19017012.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Lin MW, Chang YL, Lee YC, Huang PM: Non-functional paraganglioma of the posterior mediastinum. Interact Cardiovasc Thorac Surg; 2009 Sep;9(3):540-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-functional paraganglioma of the posterior mediastinum.
  • Mediastinal paraganglioma is a rare and slow growing neurogenic tumor.
  • Here, we describe a 49-year-old woman with a non-functional posterior mediastinal paraganglioma.
  • Mediastinal paraganglioma remains a surgical challenge due to its hypervascular character and firm adhesion to adjacent mediastinal structure.
  • Since the non-functional posterior mediastinal paraganglioma is often diagnosed after operation, it should be regarded as a differential diagnosis of mediastinal mass, especially if surgeons experience unexpected massive bleeding during operation.
  • [MeSH-major] Blood Loss, Surgical / prevention & control. Electrocoagulation. Hemostasis, Surgical. Mediastinal Neoplasms / surgery. Paraganglioma, Extra-Adrenal / surgery. Thoracic Surgery, Video-Assisted. Thoracotomy

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  • (PMID = 19491123.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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68. Thapar PM, Dalvi AN, Kamble RS, Vijaykumar V, Shah NS, Menon PS: Laparoscopic transmesocolic excision of paraganglioma in the organ of Zuckerkandl. J Laparoendosc Adv Surg Tech A; 2006 Dec;16(6):620-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic transmesocolic excision of paraganglioma in the organ of Zuckerkandl.
  • Extra-adrenal pheochromocytomas (paragangliomas) are rare.
  • We report the case of a 20-year-old female at 15 weeks gestation, who was detected to have a large paraganglioma (6.5 x 5 cm) in the organ of Zuckerkandl during an antenatal visit.
  • After medical termination of the pregnancy, successful laparoscopic excision of the paraganglioma was performed.
  • [MeSH-major] Endocrine Gland Neoplasms / surgery. Laparoscopy. Para-Aortic Bodies. Paraganglioma / surgery

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  • (PMID = 17243882.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Kennelly R, Aziz R, Toner M, Young V: Right atrial paraganglioma: an unusual primary cardiac tumour. Eur J Cardiothorac Surg; 2008 Jun;33(6):1150-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Right atrial paraganglioma: an unusual primary cardiac tumour.
  • There are no more than 50 previously reported cases of primary cardiac paraganglioma in the world literature and only a small proportion of these involve the right side of the heart.
  • [MeSH-major] Heart Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • (PMID = 18406162.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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70. Marcol W, Kiwic G, Malinowska-Kolodziej I, Kotulska K, Kotas A, Adamek D, Wysokinski T: Paraganglioma of the cauda equina presenting with erectile and sphincter dysfunction. J Chin Med Assoc; 2009 Jun;72(6):328-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraganglioma of the cauda equina presenting with erectile and sphincter dysfunction.
  • Here, we report a case of cauda equina paraganglioma with an unusual course in a 43-year-old man.
  • The patient underwent gross tumor resection, and the diagnosis of paraganglioma was based on neuropathologic examination.
  • [MeSH-major] Cauda Equina. Erectile Dysfunction / etiology. Paraganglioma, Extra-Adrenal / complications. Peripheral Nervous System Neoplasms / complications. Urination Disorders / etiology

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  • (PMID = 19541569.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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71. Brink I, Schaefer O, Walz M, Neumann HP: Fluorine-18 DOPA PET imaging of paraganglioma syndrome. Clin Nucl Med; 2006 Jan;31(1):39-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fluorine-18 DOPA PET imaging of paraganglioma syndrome.
  • A 12-year-old boy was admitted after recently having had a resection performed of an extraadrenal retroperitoneal paraganglioma and left adrenalectomy for pheochromocytoma.
  • Screening with fluorine-18 DOPA PET demonstrated increased tracer uptake in the right adrenal gland, in a second abdominal lesion, which was prevertebral, and 2 cervical hot spots near the carotid bifurcation, one on each side of the neck.
  • The patient carries a mutation of the gene Succinate dehydrogenasis subunits D (SDHD) and is thus classified with the paraganglioma syndrome type 1.
  • [MeSH-major] Abdominal Neoplasms / radionuclide imaging. Dihydroxyphenylalanine / analogs & derivatives. Head and Neck Neoplasms / radionuclide imaging. Paraganglioma / radionuclide imaging. Positron-Emission Tomography / methods

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  • (PMID = 16374125.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 2C598205QX / fluorodopa F 18; 63-84-3 / Dihydroxyphenylalanine; EC 1.3.99.1 / Succinate Dehydrogenase
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72. Singh NG, Sarkar C, Sharma MC, Garg A, Gaikwad SB, Kale SS, Mehta VS: Paraganglioma of cauda equina: report of seven cases. Brain Tumor Pathol; 2005;22(1):15-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraganglioma of cauda equina: report of seven cases.
  • The authors report seven uncommon cases of paraganglioma of the cauda equina region with reference to their clinical, radiological, and pathological findings.
  • Two mimicked ependymoma but were confirmed as paraganglioma by immunohistochemistry.
  • Thus, there were no identifying clinical or radiological features that helped in differentiating paraganglioma from other common tumors, such as ependymoma or neurinoma, in this region, and preoperative diagnosis was not possible in any of the cases.
  • This report highlights the significance of important morphologic features and immunohistochemistry in the diagnosis of paraganglioma at this unusual site.
  • [MeSH-major] Cauda Equina / pathology. Paraganglioma, Extra-Adrenal / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 18095099.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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73. Inzani F, Rindi G, Tamborrino E, Cobelli R, Bordi C: Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass. Endocr Pathol; 2009;20(3):191-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass.
  • Paragangliomas may have composite forms in which they combine features of a typical paraganglioma with those of a neural component consisting of either neuroblastoma, ganglioneuroblastoma, or ganglioneuroma.
  • These variants are rare and generally located in the adrenal.
  • Herein, we describe a retroperitoneal, extra-adrenal composite paraganglioma-ganglioneuroma of a 57-year-old woman.
  • At histology the neoplasm, strictly adhering to the external surface of the pancreatic gland but well demarcated, displayed a main central region with typical paraganglioma features and cells arranged in cords and in a nesting "zellballen" pattern, positive for neuroendocrine markers, and a distinct peripheral area consisting of dense bundles of wavy spindled Schwann cells, with scattered ganglionic cells.
  • [MeSH-major] Ganglioneuroma / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology. Paraganglioma, Extra-Adrenal / pathology

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  • (PMID = 19598001.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Paik KY: [Paraganglioma of the pancreas metastasized to the adrenal gland: a case report]. Korean J Gastroenterol; 2009 Dec;54(6):409-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Paraganglioma of the pancreas metastasized to the adrenal gland: a case report].
  • Paraganglioma is a rare neuroendocrine tumor arising from the neural crest, which includes tissues such as the adrenal medulla, carotid and aortic body, organs of Zuckerkandl, and other unnamed paraganglia.
  • The head, neck, and retroperitoneum are the most common sites for paraganglioma.
  • However, paraganglioma of the pancreas is extremely rare.
  • A well defined ovoid shape mass in left adrenal gland was suggested adenoma.
  • Microscopic examination with pancreas and adrenal gland revealed that the cells were arranged in a characteristic Zellballen pattern.
  • On the basis of these findings, we diagnosed the tumor as a paraganglioma of the pancreas and adrenal gland.
  • We report the first case of pancreas paraganglioma in Korea.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Pancreatic Neoplasms / diagnosis. Paraganglioma / diagnosis

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  • (PMID = 20026898.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / S100 Proteins; 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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75. Baysal BE: Clinical and molecular progress in hereditary paraganglioma. J Med Genet; 2008 Nov;45(11):689-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and molecular progress in hereditary paraganglioma.
  • Hereditary paraganglioma (PGL) is characterised by genetic predisposition to the development of highly vascular tumours of the paraganglionic tissues and caused by germ line inactivating mutations in the SDHB, SDHC and SDHD subunits of mitochondrial succinate dehydrogenase enzyme complex (SDH; mitochondrial complex II).
  • Recent studies have demonstrated that SDH gene mutations in germ line occur in at least 11% of non-familial head and neck paragangliomas, 8% of non-familial pheochromocytomas, 28% of malignant pheochromocytomas and 33% of extra-adrenal pheochromocytomas.
  • [MeSH-major] Paraganglioma / genetics. Paraganglioma / physiopathology. Succinate Dehydrogenase / genetics
  • [MeSH-minor] Adrenal Gland Neoplasms / genetics. Adrenal Gland Neoplasms / physiopathology. Germ-Line Mutation. Head and Neck Neoplasms / genetics. Head and Neck Neoplasms / physiopathology. Humans

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  • (PMID = 18978332.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA11236
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Number-of-references] 61
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76. Pigny P, Cardot-Bauters C: Genetics of pheochromocytoma and paraganglioma: new developments. Ann Endocrinol (Paris); 2010 Mar;71(2):76-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetics of pheochromocytoma and paraganglioma: new developments.
  • Since 2000, several new susceptibility genes for hereditary pheochromocytoma or paraganglioma have been discovered.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / genetics. Paraganglioma / diagnosis. Paraganglioma / genetics. Pheochromocytoma / diagnosis. Pheochromocytoma / genetics

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20031114.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 31
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77. Yeo H, Roman S: Pheochromocytoma and functional paraganglioma. Curr Opin Oncol; 2005 Jan;17(1):13-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pheochromocytoma and functional paraganglioma.
  • Innovations in surgical techniques and trials of adrenal sparing surgery may find a niche in the surgical armamentarium.
  • [MeSH-major] Adrenal Gland Neoplasms / physiopathology. Adrenal Gland Neoplasms / surgery. Paraganglioma / physiopathology. Paraganglioma / therapy. Pheochromocytoma / physiopathology. Pheochromocytoma / surgery

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  • (PMID = 15608506.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine
  • [Number-of-references] 29
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78. Benn DE, Richardson AL, Marsh DJ, Robinson BG: Genetic testing in pheochromocytoma- and paraganglioma-associated syndromes. Ann N Y Acad Sci; 2006 Aug;1073:104-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic testing in pheochromocytoma- and paraganglioma-associated syndromes.
  • Genetic understanding of pheochromocytoma (PHEO) and paraganglioma (PGL) syndromes has recently expanded with the identification of the involvement of the mitochondrial complex II peptides, namely the succinate dehydrogenase subunit B (SDHB), subunit C (SDHC), and subunit D (SDHD).
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genetic Testing. Paraganglioma / genetics. Pheochromocytoma / genetics


79. Chrisoulidou A, Kaltsas G, Ilias I, Grossman AB: The diagnosis and management of malignant phaeochromocytoma and paraganglioma. Endocr Relat Cancer; 2007 Sep;14(3):569-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The diagnosis and management of malignant phaeochromocytoma and paraganglioma.
  • Functional imaging using radiolabelled metaiodobenzylguanidine (MIBG) and more recently, (18)F-fluorodopamine and (18)F-fluorodopa positron emission tomography offer substantial sensitivity and specificity to correctly detect metastatic phaeochromocytoma and paraganglioma and helps identify patients suitable for treatment with radiopharmaceuticals.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Paraganglioma / diagnosis. Paraganglioma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy

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  • (PMID = 17914089.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Radiopharmaceuticals
  • [Number-of-references] 159
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80. Brink I, Hoegerle S, Klisch J, Bley TA: Imaging of pheochromocytoma and paraganglioma. Fam Cancer; 2005;4(1):61-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of pheochromocytoma and paraganglioma.
  • MRI is the morphological imaging modality of choice in localising pheochromocytomas and extra-adrenal paragangliomas.
  • The overall accuracy of computed tomography (CT) in detecting primary adrenal pheochromocytomas is very high, but CT lacks in specificity as difficulties may occur in distinguishing between paragangliomas and other tumour entities.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radionuclide imaging. Paraganglioma / pathology. Paraganglioma / radionuclide imaging. Pheochromocytoma / pathology. Pheochromocytoma / radionuclide imaging

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  • (PMID = 15883712.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 2C598205QX / fluorodopa F 18; 35MRW7B4AD / 3-Iodobenzylguanidine; 63-84-3 / Dihydroxyphenylalanine
  • [Number-of-references] 52
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81. Cascón A, López-Jiménez E, Landa I, Leskelä S, Leandro-García LJ, Maliszewska A, Letón R, de la Vega L, García-Barcina MJ, Sanabria C, Alvarez-Escolá C, Rodríguez-Antona C, Robledo M: Rationalization of genetic testing in patients with apparently sporadic pheochromocytoma/paraganglioma. Horm Metab Res; 2009 Sep;41(9):672-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rationalization of genetic testing in patients with apparently sporadic pheochromocytoma/paraganglioma.
  • Hereditary susceptibility to pheochromocytoma (PCC) and paraganglioma (PGL) represents a very complex genetic scenario.
  • On the other hand, genetic testing of SDHD should be done in all patients developing an extra-adrenal tumor before the age of 45, and SDHC could be the responsible gene in cases developing a single head and neck tumor, independently of age.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genetic Testing. Paraganglioma / genetics. Pheochromocytoma / genetics

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  • (PMID = 19343621.001).
  • [ISSN] 1439-4286
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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82. Gimenez-Roqueplo AP: New advances in the genetics of pheochromocytoma and paraganglioma syndromes. Ann N Y Acad Sci; 2006 Aug;1073:112-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New advances in the genetics of pheochromocytoma and paraganglioma syndromes.
  • The discovery of the SDH genes in 2000/2001 dramatically changed the genetics of pheochromocytoma (PHEO) and paraganglioma (PGL).
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics

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  • (PMID = 17102078.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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83. Snabboon T, Plengpanich W, Houngngam N, Buranasupkajorn P, Plengvidhya N, Sereepapong W, Sunthornyothin S, Shotelersuk V: Concurrent bilateral pheochromocytoma and thoracic paraganglioma during pregnancy. Endocrine; 2010 Apr;37(2):261-4
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  • [Title] Concurrent bilateral pheochromocytoma and thoracic paraganglioma during pregnancy.
  • After the fetal death, additional studies were performed and revealed a thoracic paraganglioma.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Mediastinal Neoplasms / complications. Paraganglioma / complications. Pheochromocytoma / complications. Pregnancy Complications, Neoplastic. von Hippel-Lindau Disease / complications


84. Geli J, Kiss N, Lanner F, Foukakis T, Natalishvili N, Larsson O, Kogner P, Höög A, Clark GJ, Ekström TJ, Bäckdahl M, Farnebo F, Larsson C: The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma. Endocr Relat Cancer; 2007 Mar;14(1):125-34
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  • [Title] The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma.
  • In this study, we aimed to explore the potential involvement of NORE1A and RASSF1A in pheochromocytoma and abdominal paraganglioma tumorigenesis.
  • Significantly suppressed NORE1A and RASSF1A mRNA levels were detected in primary tumours compared with normal adrenal medulla (P<0.001).
  • Our study provides evidence that NORE1A and RASSF1A are frequently suppressed in pheochromocytoma and abdominal paraganglioma.
  • [MeSH-major] Abdominal Neoplasms / genetics. Monomeric GTP-Binding Proteins / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 17395981.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RASSF1 protein, human; 0 / RASSF5 protein, human; 0 / RNA, Messenger; 0 / Sulfites; 0 / Tumor Suppressor Proteins; EC 3.6.5.2 / Monomeric GTP-Binding Proteins; OJ9787WBLU / hydrogen sulfite
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85. Siedek V, Waggershauser T, Berghaus A, Matthias C: Intraoperative monitoring of intraarterial paraganglioma embolization by indocyaningreen fluorescence angiography. Eur Arch Otorhinolaryngol; 2009 Sep;266(9):1449-54
Hazardous Substances Data Bank. INDOCYANINE GREEN .

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  • [Title] Intraoperative monitoring of intraarterial paraganglioma embolization by indocyaningreen fluorescence angiography.
  • Preoperative arterial embolization (AE) of paraganglioma (PG) is widely used to diminish intraoperative blood loss.
  • [MeSH-major] Coloring Agents. Embolization, Therapeutic. Fluorescein Angiography. Head and Neck Neoplasms / surgery. Indocyanine Green. Monitoring, Intraoperative. Paraganglioma, Extra-Adrenal / blood supply. Paraganglioma, Extra-Adrenal / surgery

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  • (PMID = 19052762.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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86. Sudbrock F, Schmidt M, Simon T, Eschner W, Berthold F, Schicha H: Dosimetry for 131I-MIBG therapies in metastatic neuroblastoma, phaeochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging; 2010 Jul;37(7):1279-90
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dosimetry for 131I-MIBG therapies in metastatic neuroblastoma, phaeochromocytoma and paraganglioma.
  • Despite the significant role of the radiopharmaceutical (131)I-metaiodobenzylguanidine (MIBG) for the treatment of metastatic neuroblastoma, phaeochromocytoma and paraganglioma details for a reliable dosimetry are still sparse.
  • [MeSH-major] 3-Iodobenzylguanidine / therapeutic use. Adrenal Gland Neoplasms / radiotherapy. Neoplasm Metastasis / radiotherapy. Neuroblastoma / radiotherapy. Paraganglioma / radiotherapy. Pheochromocytoma / radiotherapy. Radiometry / methods

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  • (PMID = 20179922.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 35MRW7B4AD / 3-Iodobenzylguanidine
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87. Hammond PJ, Murphy D, Carachi R, Davidson DF, McIntosh D: Childhood phaeochromocytoma and paraganglioma: 100% incidence of genetic mutations and 100% survival. J Pediatr Surg; 2010 Feb;45(2):383-6
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood phaeochromocytoma and paraganglioma: 100% incidence of genetic mutations and 100% survival.
  • INTRODUCTION: The aim is to identify the incidence of genetic mutations and outcome of children presenting with phaeochromocytoma/paraganglioma (PGL) to a single paediatric surgical service to determine the need for genetic counselling in associated kindreds.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Mutation / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20152357.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret
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88. Bayley JP, Grimbergen AE, van Bunderen PA, van der Wielen M, Kunst HP, Lenders JW, Jansen JC, Dullaart RP, Devilee P, Corssmit EP, Vriends AH, Losekoot M, Weiss MM: The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients. BMC Med Genet; 2009;10:34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients.
  • BACKGROUND: Germline mutations of the tumor suppressor genes SDHB, SDHC and SDHD play a major role in hereditary paraganglioma and pheochromocytoma.
  • Index patients presented with pheochromocytoma, extra-adrenal PGL and HN-PGL.
  • In this small series HN-PGL occurs as frequently as pheochromocytoma and extra-adrenal PGL.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genes, Tumor Suppressor. Paraganglioma, Extra-Adrenal / genetics. Pheochromocytoma / genetics. Succinate Dehydrogenase / genetics

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  • (PMID = 19368708.001).
  • [ISSN] 1471-2350
  • [Journal-full-title] BMC medical genetics
  • [ISO-abbreviation] BMC Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Other-IDs] NLM/ PMC2670821
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89. Benn DE, Gimenez-Roqueplo AP, Reilly JR, Bertherat J, Burgess J, Byth K, Croxson M, Dahia PL, Elston M, Gimm O, Henley D, Herman P, Murday V, Niccoli-Sire P, Pasieka JL, Rohmer V, Tucker K, Jeunemaitre X, Marsh DJ, Plouin PF, Robinson BG: Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes. J Clin Endocrinol Metab; 2006 Mar;91(3):827-36
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  • [Title] Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes.
  • CONTEXT: The identification of mutations in genes encoding peptides of succinate dehydrogenase (SDH) in pheochromocytoma/paraganglioma syndromes has necessitated clear elucidation of genotype-phenotype associations.
  • OBJECTIVE: Our objective was to determine genotype-phenotype associations in a cohort of patients with pheochromocytoma/paraganglioma syndromes and succinate dehydrogenase subunit B (SDHB) or subunit D (SDHD) mutations.
  • DESIGN, SETTING, AND PARTICIPANTS: The International SDH Consortium studied 116 individuals (83 affected and 33 clinically unaffected) from 62 families with pheochromocytoma/paraganglioma syndromes and SDHB or SDHD mutations.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Mutation. Paraganglioma / genetics. Pheochromocytoma / genetics


90. Bayley JP, van Minderhout I, Hogendoorn PC, Cornelisse CJ, van der Wal A, Prins FA, Teppema L, Dahan A, Devilee P, Taschner PE: Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma. PLoS One; 2009;4(11):e7987
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma.
  • Mutations of SDHD, the first protein of intermediary metabolism shown to be involved in tumorigenesis, lead to the human tumors paraganglioma (PGL) and pheochromocytoma (PC).
  • No paraganglioma or other tumor development was seen in Sdhd KO mice followed for their entire lifespan, in sharp contrast to the highly penetrant phenotype in humans.
  • Heterozygous Sdhd KO mice did not show hyperplasia of paraganglioma-related tissues such as the carotid body or of the adrenal medulla, or any genotype-related pathology, with similar body and organ weights to wildtype mice.
  • [MeSH-major] Mutation. Paraganglioma / genetics. Pheochromocytoma / genetics. RNA, Untranslated / genetics. Succinate Dehydrogenase / genetics

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  • (PMID = 19956719.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / H19 long non-coding RNA; 0 / RNA, Long Noncoding; 0 / RNA, Untranslated; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Other-IDs] NLM/ PMC2776493
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91. Kantorovich V, King KS, Pacak K: SDH-related pheochromocytoma and paraganglioma. Best Pract Res Clin Endocrinol Metab; 2010 Jun;24(3):415-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SDH-related pheochromocytoma and paraganglioma.
  • Pheochromocytoma and paraganglioma are rare tumors of adrenals as well as the sympathetic and parasympathetic paraganglia.
  • [MeSH-major] Adrenal Gland Neoplasms / enzymology. Adrenal Gland Neoplasms / genetics. Paraganglioma / enzymology. Paraganglioma / genetics. Pheochromocytoma / enzymology. Pheochromocytoma / genetics. Succinate Dehydrogenase / genetics

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  • [Copyright] Published by Elsevier Ltd.
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  • (PMID = 20833333.001).
  • [ISSN] 1878-1594
  • [Journal-full-title] Best practice & research. Clinical endocrinology & metabolism
  • [ISO-abbreviation] Best Pract. Res. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HD008735-07; United States / Intramural NIH HHS / / Z01 HD008735-08
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
  • [Other-IDs] NLM/ NIHMS224233; NLM/ PMC2939070
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92. Benn DE, Robinson BG: Genetic basis of phaeochromocytoma and paraganglioma. Best Pract Res Clin Endocrinol Metab; 2006 Sep;20(3):435-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic basis of phaeochromocytoma and paraganglioma.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics

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  • (PMID = 16980204.001).
  • [ISSN] 1521-690X
  • [Journal-full-title] Best practice & research. Clinical endocrinology & metabolism
  • [ISO-abbreviation] Best Pract. Res. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 81
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93. Jahangir N, Shirazi B: Paraganglioma: a diagnostic dilemma. J Pak Med Assoc; 2010 Sep;60(9):789-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraganglioma: a diagnostic dilemma.
  • We report a case of intra abdominal paraganglioma in a 46-year-old male, that measured 12.5 x 10 x 10 cm and weighed 340 grams.
  • Histologically paraganglioma was composed of tumour cells that had abundant, granular to clear eosinophilic cytoplasm and mildly pleomorphic, vesicular rounded nuclei.
  • These are diagnostic for paraganglioma.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis

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  • (PMID = 21381599.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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94. Korpershoek E, Petri BJ, van Nederveen FH, Dinjens WN, Verhofstad AA, de Herder WW, Schmid S, Perren A, Komminoth P, de Krijger RR: Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma. Endocr Relat Cancer; 2007 Jun;14(2):453-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.
  • Pheochromocytomas (PCCs) are rare tumors that arise from chromaffin tissue in the adrenal medulla, but can also occur in the abdomen outside the adrenals and are then called sympathetic paragangliomas (sPGLs).
  • According to the literature, between 15 and 25% of apparently sporadic adrenal PCC and sPGL are caused by germline mutations in RET, von Hippel-Lindau disease (VHL), succinate dehydrogenase subunit B (SDHB), or subunit D SDHD.
  • However, few studies have addressed the mutationfrequency of these candidate genes in selected subgroups of PCC andsPGL, such as bilateral adrenal PCC or extra-adrenal sPGL, and none have looked at somatic mutations by analyzing tumor tissue.
  • Therefore, we have investigated the occurrence of germline and somatic mutations in RET, VHL, SDHB, and SDHD in comparatively large series of bilateral adrenal PCC (n = 33 patients) and sPGL (n = 26 patients), with the aim of determining the mutation frequency of each of these genes and to establish a genetic testing algorithm.
  • Twenty-one RET, two VHL germline, and one SDHD mutations were found in the patients with bilateral adrenal PCC.
  • We suggest that sequential mutation analysis should be directed first at RET, followed by VHL and SDHD for patients with bilateral adrenal PCC at diagnosis, and at SDHB and SDHD for patients with sPGL.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genes, Neoplasm. Paraganglioma / genetics. Pheochromocytoma / genetics

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  • (PMID = 17639058.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins; 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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95. Kelliher K, Santiago A, Estrada DE, Campbell BT: Laparoscopic excision of a familial paraganglioma. J Laparoendosc Adv Surg Tech A; 2009 Apr;19 Suppl 1:S155-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic excision of a familial paraganglioma.
  • Pheochromocytomas are rare neuroendocrine tumors that secrete catecholamines and usually arise from the adrenal medulla.
  • Catecholamine-producing tumors that arise from extra-adrenal chromaffin tissue are referred to as paragangliomas, or extra-adrenal pheochromocytomas.
  • Contrary to the traditional "Rule of Tens," as many as 25% of pheochromocytomas occur in hereditary tumor syndromes, such as multiple endocrine neoplasia-2, von Hippel-Lindau disease, neurofibromatosis-1, or hereditary or familial paraganglioma syndrome.
  • This case report and the accompanying video demonstrate that the laparoscopic approach to retroperitoneal paraganglioma resection provides excellent exposure of the tumor and surrounding structures.
  • [MeSH-major] Laparoscopy. Paraganglioma / surgery. Paraganglioma, Extra-Adrenal / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 19260793.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Kudoh A, Tokuhisa Y, Morita K, Hiraki S, Fukuda S, Eguchi N, Iwata T: Mesenteric paraganglioma: report of a case. Surg Today; 2005;35(7):594-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric paraganglioma: report of a case.
  • We report a rare case of a solitary primary paraganglioma arising in the mesentery, found in a 72-year-old woman who presented with abdominal pain and a palpable abdominal mass.
  • This extra-abdominal paraganglioma developed from paraganglionic cells that travelled by vertebral migration from the root of the superior mesenteric artery.
  • Extra-adrenal paraganglia extend anywhere from the neck down to the base of the pelvis.
  • It was diagnosed as a paraganglioma histologically.
  • The patient is free from recurrence of paraganglioma after 1 year of follow up.
  • To our knowledge, this represents only the seventh case of a paraganglioma arising in the mesentery.
  • [MeSH-major] Paraganglioma / diagnosis. Peritoneal Neoplasms / diagnosis

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  • [Cites] Radiographics. 1991 Jan;11(1):37-57 [1671719.001]
  • [Cites] Ann Surg. 1956 Jul;144(1):133-7 [13327852.001]
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  • (PMID = 15976959.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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97. Dundee P, Clancy B, Wagstaff S, Briggs R: Paraganglioma: the role of genetic counselling and radiological screening. J Clin Neurosci; 2005 May;12(4):464-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraganglioma: the role of genetic counselling and radiological screening.
  • Genetic predisposition to develop paraganglioma can occur within known tumour syndromes and familial tumours tend to present at a younger age and at multiple sites compared to sporadic tumours.
  • We present a case of a 14-year-old boy with multiple paraganglioma and a strong family history of paraganglioma.
  • He suffered significant morbidity at resection of an extra-adrenal retroperitoneal tumour due to late diagnosis and was later unable to undergo excision of a head and neck paraganglioma due to its size and relation to neurovascular structures in the neck.
  • We review the current literature on suggested genetic counselling (psychological counselling and DNA analysis) and radiological screening guidelines and recommend that genetic counselling should be offered to all patients with a family history of paraganglioma from the age of 5 years.
  • Those positive for paternal paraganglioma locus gene should then undergo regular radiological screening with MRI.
  • [MeSH-major] Brain Neoplasms / genetics. Brain Neoplasms / pathology. Genetic Counseling. Magnetic Resonance Imaging. Paraganglioma / genetics

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  • (PMID = 15925783.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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98. de Montpréville VT, Mussot S, Gharbi N, Dartevelle P, Dulmet E: Paraganglioma with ganglioneuromatous component located in the posterior mediastinum. Ann Diagn Pathol; 2005 Apr;9(2):110-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraganglioma with ganglioneuromatous component located in the posterior mediastinum.
  • The tumor displayed both paraganglioma and ganglioneuroma areas that were in equal proportion and often merged one into the other.
  • Paraganglioma areas contained synaptophysin and chromogranin-positive chief cells and PS100-positive sustentacular cells.
  • Such pheochromocytoma-ganglioneuroma has not been previously reported in the mediastinum and appears as the adrenal and aorticosympathetic counterpart of gangliocytic paraganglioma described in other anatomic sites.
  • [MeSH-major] Ganglioneuroma / pathology. Mediastinal Neoplasms / pathology. Paraganglioma / pathology

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  • (PMID = 15806520.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Kovacs K, Bell D, Gardiner GW, Honey RJ, Goguen J, Rotondo F: Malignant paraganglioma of the urinary bladder: Immunohistochemical study of prognostic indicators. Endocr Pathol; 2005;16(4):363-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant paraganglioma of the urinary bladder: Immunohistochemical study of prognostic indicators.
  • Using various immunohistochemical markers, the objective of our study was to assess whether correlation exists between growth potential of paraganglioma (pheochromocytoma) cells and formation of metastasis.
  • He had no constitutional symptoms to suggest paraganglioma.
  • Histologic, immunohistochemical, and electron microscopic investigation of the surgically removed tissue proved that the tumor was a malignant paraganglioma with metastases in the regional lymph nodes.
  • [MeSH-major] Paraganglioma, Extra-Adrenal / metabolism. Paraganglioma, Extra-Adrenal / pathology. Urinary Bladder Neoplasms / metabolism. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16627923.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Bayley JP, van Minderhout I, Weiss MM, Jansen JC, Oomen PH, Menko FH, Pasini B, Ferrando B, Wong N, Alpert LC, Williams R, Blair E, Devilee P, Taschner PE: Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. BMC Med Genet; 2006;7:1
SciCrunch. OMIM: Data: Gene Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma.
  • BACKGROUND: Germline mutations of the SDHD, SDHB and SDHC genes, encoding three of the four subunits of succinate dehydrogenase, are a major cause of hereditary paraganglioma and pheochromocytoma, and demonstrate that these genes are classic tumor suppressors.
  • METHODS: Using conformation sensitive gel electrophoresis (CSGE) and direct DNA sequencing to analyse genomic DNA from peripheral blood lymphocytes, here we describe the mutation analysis of the SDHB and SDHC genes in 37 patients with sporadic (i.e. no known family history) head and neck paraganglioma and five pheochromocytoma and/or paraganglioma families.
  • Together with our previous results, we found 27 germline mutations of SDH genes in 95 cases (28%) of sporadic head and neck paraganglioma.
  • In addition all index patients of five families showing hereditary pheochromocytoma-paraganglioma were found to carry germline mutations of SDHB: four of which were novel, c.343C>T (p.Arg115X), c.141G>A (p.Trp47X), c.281G>A (p.Arg94Lys), and c.653G>C (p.Trp218Ser), and one reported previously, c.136C>T, p.Arg46X.
  • CONCLUSION: In conclusion, these data indicate that germline mutations of SDHB and SDHC play a minor role in sporadic head and neck paraganglioma and further underline the importance of germline SDHB mutations in cases of familial pheochromocytoma-paraganglioma.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Germ-Line Mutation. Head and Neck Neoplasms / genetics. Iron-Sulfur Proteins / genetics. Membrane Proteins / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics. Protein Subunits / genetics. Succinate Dehydrogenase / genetics

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  • (PMID = 16405730.001).
  • [ISSN] 1471-2350
  • [Journal-full-title] BMC medical genetics
  • [ISO-abbreviation] BMC Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins; 0 / Membrane Proteins; 0 / Protein Subunits; 0 / RNA Splice Sites; 0 / SDHC protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
  • [Other-IDs] NLM/ PMC1343542
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