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1. Fukushi D, Watanabe N, Kasai F, Haruta M, Kikuchi A, Kikuta A, Kato K, Nakadate H, Tsunematsu Y, Kaneko Y: Centrosome amplification is correlated with ploidy divergence, but not with MYCN amplification, in neuroblastoma tumors. Cancer Genet Cytogenet; 2009 Jan 1;188(1):32-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Centrosome amplification is correlated with ploidy divergence, but not with MYCN amplification, in neuroblastoma tumors.
  • Ploidy is an important biologic feature defining heterogeneous neuroblastoma.
  • [MeSH-major] Centrosome / metabolism. Chromosomes, Human, Pair 1 / genetics. Gene Dosage. Neuroblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. Ploidies
  • [MeSH-minor] Adrenal Gland Neoplasms / genetics. Child. Child, Preschool. Flow Cytometry. Gene Amplification. Humans. In Situ Hybridization, Fluorescence. Infant. Infant, Newborn. Mediastinal Neoplasms / genetics. Retroperitoneal Neoplasms / genetics

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  • (PMID = 19061778.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins
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2. Leclair MD, de Lagausie P, Becmeur F, Varlet F, Thomas C, Valla JS, Petit T, Philippe-Chomette P, Mure PY, Sarnacki S, Michon J, Heloury Y: Laparoscopic resection of abdominal neuroblastoma. Ann Surg Oncol; 2008 Jan;15(1):117-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic resection of abdominal neuroblastoma.
  • BACKGROUND: Since indications for laparoscopic adrenalectomy have progressively expanded to pediatric surgery, preliminary reports have studied the laparoscopic approach for abdominal neuroblastoma (NB).
  • Primary site of the tumor was the adrenal gland in 41 cases and retroperitoneal space in 4.
  • CONCLUSION: Laparoscopic resection of abdominal primary allows effective local control of the disease in a wide range of clinical situations of neuroblastoma, with an acceptable morbidity.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Laparoscopy. Neuroblastoma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Humans. Infant. Infant, Newborn. Male. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome


3. Merrot T, Oubejja H, Chaumoitre K, Alessandrini P: [Neonatal uro-haematoma secondary to posterior urethral valve]. Prog Urol; 2005 Feb;15(1):63-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The diagnosis of right perirenal extracapsular uro-haematoma secondary to posterior urethral valve was proposed on the basis of the antenatal clinical history.
  • The neonatal diagnosis of a heterogeneous renal cystic mass is sometimes difficult (polycystic renal dysplasia, cystic lymphangioma, cystic neuroblastoma, adrenal haematoma).
  • In some cases, the antenatal history may suggest the diagnosis of perirenal urohaematoma secondary to infravesical obstruction.

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  • (PMID = 15822395.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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4. Kremens B: [Systemic therapy in children and adolescents]. Urologe A; 2007 Oct;46(10):1404-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • National and supranational treatment studies are the standard of care for pediatric cancer in Germany; they yield 5-year survival rates of almost 90% for nephroblastoma and germ cell tumors and 60% for neuroblastoma (all stages) and rhabdomyosarcoma.
  • In a multimodal treatment strategy, the role of chemotherapy as well as that of surgery and radiotherapy can differ, as is described for nephroblastoma, infant neuroblastoma, and stage 4 neuroblastoma.
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / mortality. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / surgery. Adrenal Medulla. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Humans. Infant. Kidney Neoplasms / drug therapy. Kidney Neoplasms / mortality. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Neoplasm Staging. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / mortality. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Neuroblastoma / drug therapy. Neuroblastoma / mortality. Neuroblastoma / pathology. Neuroblastoma / surgery. Prognosis. Radiotherapy, Adjuvant. Rhabdomyosarcoma / drug therapy. Rhabdomyosarcoma / mortality. Rhabdomyosarcoma / pathology. Rhabdomyosarcoma / surgery. Survival Rate. Wilms Tumor / drug therapy. Wilms Tumor / mortality. Wilms Tumor / pathology. Wilms Tumor / surgery

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  • (PMID = 17823786.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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5. Salmi D, Patel C, Imashuku S, Shimada H, Satake N: Neuroblastoma of unknown primary site with periorbital bone metastasis in a child. Pediatr Blood Cancer; 2010 Aug;55(2):361-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroblastoma of unknown primary site with periorbital bone metastasis in a child.
  • Neuroblastoma is the second most common solid tumor in children.
  • Most tumors arise in the adrenal glands or paravertebral region.
  • [MeSH-major] Neuroblastoma / secondary. Orbital Neoplasms / secondary

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20582979.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Vasudevan SA, Cumbie TA, Dishop MK, Nuchtern JG: Retroperitoneal hemangioma of infancy. J Pediatr Surg; 2006 Jan;41(1):e41-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A premature infant presented with an incidental finding of a mass in the retroperitoneum adjacent to the adrenal gland seen on a renal ultrasound study.
  • A clinical diagnosis of neuroblastoma was made based on imaging and laboratory studies; however, upon resection, histological examination revealed a cellular capillary hemangioma of infancy.
  • Hemangioma should be considered in the differential diagnosis of asymptomatic retroperitoneal mass lesions in infants.
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant, Newborn. Infant, Premature. Male

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  • (PMID = 16410088.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Rescorla FJ: Malignant adrenal tumors. Semin Pediatr Surg; 2006 Feb;15(1):48-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant adrenal tumors.
  • Adrenal tumors, apart from neuroblastoma, are relatively rare in infancy and childhood.
  • Most adrenal lesions are benign, and both benign and malignant tumors may be hormonally active thus, making accurate preoperative diagnosis difficult.
  • The two main malignant tumors are adrenocortical carcinoma and pheochromocytoma.
  • In both tumors, it may be difficult to determine benign from malignant and the biologic behavior and degree of invasion may portend a more malignant course.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Adrenocortical Carcinoma / diagnosis. Adrenocortical Carcinoma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy

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  • (PMID = 16458846.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 98
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8. Al-Shanafey S, Habib Z: Feasibility and safety of laparoscopic adrenalectomy in children: special emphasis on neoplastic lesions. J Laparoendosc Adv Surg Tech A; 2008 Apr;18(2):306-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Laparoscopic adrenalectomy (LA) in children became a viable option for the resection of adrenal lesions.
  • In this paper, we report our experience with LA over the last 10 years, with special emphasis on malignant lesions.
  • Adrenal lesions were left sided in 15, right sided in 11, and bilateral in 3 patients.
  • Twenty-one patients had malignant lesions, while 8 had benign lesions.
  • Resection margins were positive for tumor in 5 cases (17%), and all had stage IV neuroblastoma.
  • Follow-up range was from 9 months to 9.5 years (9 months to 6.3 years for malignant lesions).
  • One patient managed for bilateral neuroblastoma has stable residual disease 17 months after resection.
  • At the time of this report, 3 patients with neuroblastoma had died with progressive metastatic refractory disease.
  • CONCLUSIONS: Our data have shown the feasibility, safety, and effectiveness of LA for adrenal lesions, including malignant tumors.
  • The relatively long follow-up data regarding the malignant lesions attest to its role in the management of such lesions.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy. Laparoscopy

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  • (PMID = 18373464.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Heath JA, Moore K, Spriggs M, Waters KD: When two worlds collide. J Clin Oncol; 2007 Sep 1;25(25):4015-7; discussion 4018-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adrenal Gland Neoplasms / economics. Adrenal Gland Neoplasms / therapy. Bone Marrow Neoplasms / secondary. Bone Neoplasms / secondary. Delivery of Health Care / economics. Neuroblastoma / secondary. Neuroblastoma / therapy. Referral and Consultation / economics


10. Katanoda K, Hayashi K, Yamamoto K, Sobue T: Secular trends in neuroblastoma mortality before and after the cessation of national mass screening in Japan. J Epidemiol; 2009;19(5):266-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secular trends in neuroblastoma mortality before and after the cessation of national mass screening in Japan.
  • BACKGROUND: In 2003, the Japanese government halted the national mass screening program for neuroblastoma (NB), which had been running since the mid-1980s.
  • METHODS: Utilizing vital statistics data from 1980 through 2006, we analyzed the secular trends in NB mortality by using cancer of the adrenal gland as a surrogate.
  • RESULTS: The number of deaths from cancer of the adrenal gland was closely correlated with the number of deaths from NB.


11. Iżycka-Świeszewska E, Drożyńska E, Rzepko R, Kobierska-Gulida G, Grajkowska W, Perek D, Balcerska A: Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumours. Pol J Pathol; 2010;61(4):192-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neuroblastoma (NB) represents one of the most common paediatric tumours.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neuroblastoma / pathology. Oncogene Protein v-akt / metabolism. Phosphatidylinositol 3-Kinase / metabolism. TOR Serine-Threonine Kinases / metabolism
  • [MeSH-minor] Abdominal Neoplasms. Adolescent. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Child. Child, Preschool. Humans. Infant. Neoplasm Staging. Signal Transduction


12. Hoshi N, Sugino T, Suzuki T: Expression of endothelin system in neuroblastic tumors: close association of endothelin-1 and endothelin B receptor expression with differentiation of tumor cells. Med Mol Morphol; 2009 Jun;42(2):110-7
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  • We immunohistochemically examined for localization of ET-1, ET-3, ET-A receptor (ET-A), and ET-B receptor (ET-B) in 24 ganglioneuromas, 8 ganglioneuroblastomas, 37 neuroblastomas, 14 normal sympathetic ganglia, and 10 fetal adrenal glands with regard to neuroblastic cell differentiation.
  • Neuroblasts in fetal adrenal glands expressed ET-B (100%) alone.
  • [MeSH-major] Adrenal Gland Neoplasms / chemistry. Endothelin-1 / analysis. Ganglioneuroblastoma / chemistry. Neuroblastoma / chemistry. Receptor, Endothelin B / analysis
  • [MeSH-minor] Adrenal Glands / chemistry. Adrenal Glands / pathology. Adult. Cell Differentiation. Endothelin-3 / analysis. Endothelins. Fetus. Ganglia, Sympathetic / chemistry. Ganglia, Sympathetic / embryology. Humans. Neurons / chemistry. Neurons / pathology. Receptor, Endothelin A / analysis. Stem Cells / chemistry. Stem Cells / pathology

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  • (PMID = 19536618.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Endothelin-1; 0 / Endothelin-3; 0 / Endothelins; 0 / Receptor, Endothelin A; 0 / Receptor, Endothelin B
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13. Seefelder C, Sparks JW, Chirnomas D, Diller L, Shamberger RC: Perioperative management of a child with severe hypertension from a catecholamine secreting neuroblastoma. Paediatr Anaesth; 2005 Jul;15(7):606-10
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  • [Title] Perioperative management of a child with severe hypertension from a catecholamine secreting neuroblastoma.
  • We report the perioperative management of a 5 year old child with stage III adrenal neuroblastoma who presented with malignant hypertension and high norepinephrine and dopamine levels.
  • [MeSH-major] Catecholamines / metabolism. Catecholamines / physiology. Hypertension / etiology. Hypertension / therapy. Kidney Neoplasms / complications. Kidney Neoplasms / metabolism. Neuroblastoma / complications. Neuroblastoma / metabolism


14. Muhlstein J, Rodriguez-Dahlhoff S, Marie B, Fouyssac F: Primary ovarian neuroblastoma. J Pediatr Adolesc Gynecol; 2010 Oct;23(5):263-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary ovarian neuroblastoma.
  • BACKGROUND: The diagnosis of neuroblastoma is rare after the age of 15 years, and anatomical locations are essentially the adrenal glands and paraspinal sites.
  • CASE REPORT: We report the case of a 17-year-old young woman in whom the diagnosis of primary ovarian neuroblastoma associated with a mature teratoma was established.
  • [MeSH-major] Neoplasms, Second Primary / pathology. Neuroblastoma / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Neoplasm Staging

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  • [Copyright] Copyright 2010 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Pediatr Adolesc Gynecol. 2010 Oct;23(5):261-2 [20813329.001]
  • (PMID = 20371194.001).
  • [ISSN] 1873-4332
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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15. Pellkofer HL, Voltz R, Goebels N, Hohlfeld R, Dornmair K: Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue. Arch Neurol; 2009 May;66(5):655-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: According to established criteria, paraneoplastic encephalomyelitis with adrenal neuroblastoma comprises a definite paraneoplastic neurologic syndrome.
  • Patient A 22-year-old woman having paraneoplastic encephalomyelitis with adrenal neuroblastoma.
  • MAIN OUTCOME MEASURES: We compared the T-cell receptor repertoires expressed in blood, cerebrospinal fluid, and neuroblastoma tumor tissue using complementary determining region 3 (CDR3) spectratyping and clone-specific polymerase chain reaction.
  • [MeSH-major] Adrenal Gland Neoplasms / immunology. Neuroblastoma / immunology. Paraneoplastic Syndromes, Nervous System / immunology. Receptors, Antigen, T-Cell / analysis
  • [MeSH-minor] Antigens, Neoplasm / analysis. Antigens, Neoplasm / classification. Biomarkers / analysis. Biomarkers / blood. Biomarkers / cerebrospinal fluid. Cell Lineage / immunology. Clone Cells / immunology. Cross Reactions / immunology. Female. Humans. Immunophenotyping. Lymphocyte Activation / immunology. Receptors, Antigen, T-Cell, alpha-beta / analysis. T-Lymphocyte Subsets / immunology. T-Lymphocytes / classification. T-Lymphocytes / immunology. Young Adult

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  • [CommentIn] Arch Neurol. 2009 Oct;66(10):1299-300; author reply 300 [19822792.001]
  • (PMID = 19433667.001).
  • [ISSN] 1538-3687
  • [Journal-full-title] Archives of neurology
  • [ISO-abbreviation] Arch. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Receptors, Antigen, T-Cell; 0 / Receptors, Antigen, T-Cell, alpha-beta
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16. Donfrancesco A, Jenkner A, De Ioris MA, Ilari I, Castellano A, De Laurentis C, Garganese MC, Milano GM, Dominici C: Prolonged response to oral gefitinib, cyclophosphamide, and topotecan in heavily pretreated relapsed stage 4 neuroblastoma: a case report. J Pediatr Hematol Oncol; 2007 Nov;29(11):799-803
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prolonged response to oral gefitinib, cyclophosphamide, and topotecan in heavily pretreated relapsed stage 4 neuroblastoma: a case report.
  • A girl with metastatic neuroblastoma diagnosed at 4 years of age experienced an early disseminated relapse after high-dose chemotherapy.
  • This combination may represent a viable therapeutic option and deserves further evaluation in resistant neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / drug therapy. Antineoplastic Combined Chemotherapy Protocols. Cyclophosphamide / administration & dosage. Neuroblastoma / drug therapy. Quinazolines / administration & dosage. Topotecan / administration & dosage

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  • (PMID = 17984703.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Quinazolines; 7M7YKX2N15 / Topotecan; 8N3DW7272P / Cyclophosphamide; S65743JHBS / gefitinib
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17. Karmakar S, Choudhury SR, Banik NL, Ray SK: Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. Neuroscience; 2009 Sep 29;163(1):286-95
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  • [Title] Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts.
  • Neuroblastoma is the childhood malignancy that mainly occurs in adrenal glands and is found also in the neck, chest, abdomen, and pelvis.
  • In this investigation, we examined efficacy of the retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) and the isoflavonoid genistein (GST) alone and also in combination for controlling the growth of human malignant neuroblastoma SK-N-BE2 and SH-SY5Y xenografts in nude mice.
  • Combination of 4-HPR and GST significantly reduced tumor volume in vivo due to overwhelming apoptosis in both neuroblastoma xenografts.
  • Results demonstrated that combination of 4-HPR and GST induced multiple molecular mechanisms for apoptosis and thus could be highly effective for inhibiting growth of malignant neuroblastoma in preclinical animal models.

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  • (PMID = 19540315.001).
  • [ISSN] 1873-7544
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA091460-06; United States / NINDS NIH HHS / NS / R01 NS057811-04; United States / NCI NIH HHS / CA / R01 CA-91460; United States / NCI NIH HHS / CA / R01 CA091460; United States / NINDS NIH HHS / NS / R01 NS-57811; United States / NCI NIH HHS / CA / CA091460-06; United States / NINDS NIH HHS / NS / R01 NS057811
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Apoptosis Regulatory Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / NF-kappa B; 20638-84-0 / retinamide; 5688UTC01R / Tretinoin; DH2M523P0H / Genistein
  • [Other-IDs] NLM/ NIHMS132212; NLM/ PMC3103945
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18. Castle V, Kwok R, Opipari A, Subramanian C: Ku70 acetylation in neuroblastoma pathogenesis and therapy. Trans Am Clin Climatol Assoc; 2010;121:183-91; discussion 191
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  • [Title] Ku70 acetylation in neuroblastoma pathogenesis and therapy.
  • Neuroblastoma is a cancer that occurs in children.
  • It develops from stem cells that normally give rise to parts of the peripheral nervous system and adrenal glands.
  • Although most children with localized neuroblastoma are cured, children with wide-spread disease have a small chance of survival even after surgery, chemotherapy, radiation and bone marrow transplantation.
  • To solve this problem, we are working to understand which molecules in the stem cells from which this cancer arises malfunction to cause neuroblastoma and apply this information to develop new models to treat this disease.
  • [MeSH-major] Antigens, Nuclear / metabolism. DNA-Binding Proteins / metabolism. Neuroblastoma / metabolism

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  • (PMID = 20697560.001).
  • [ISSN] 0065-7778
  • [Journal-full-title] Transactions of the American Clinical and Climatological Association
  • [ISO-abbreviation] Trans. Am. Clin. Climatol. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / BAX protein, human; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Histone Deacetylase Inhibitors; 0 / Ku autoantigen; 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC2917135
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19. McGarvey CK, Applegate K, Lee ND, Sokol DK: False-positive metaiodobenzylguanidine scan for neuroblastoma in a child with opsoclonus-myoclonus syndrome treated with adrenocorticotropic hormone (acth). J Child Neurol; 2006 Jul;21(7):606-10
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  • [Title] False-positive metaiodobenzylguanidine scan for neuroblastoma in a child with opsoclonus-myoclonus syndrome treated with adrenocorticotropic hormone (acth).
  • We describe the case of a 2-year-old girl with opsoclonus-myoclonus syndrome treated with chronic adrenocorticotropic hormone (ACTH) in which a metaiodobenzylguanidine scan showed abnormal radiotracer uptake in the left adrenal gland region, interpreted as the site of an occult neuroblastoma.
  • As this finding was not corroborated by previous or subsequent metaiodobenzylguanidine scans or by computed tomography (CT) or magnetic resonance imaging (MRI), we attribute the finding to being a false-positive result from adrenal hyperplasia owing to chronic use of ACTH and not to neuroblastoma.
  • Metaiodobenzylguanidine scintigraphy is an extremely important nuclear medicine examination tool used for the evaluation and staging of pediatric neuroblastoma.
  • We highlight the need for cautious interpretation of metaiodobenzylguanidine as a screening tool for neuroblastoma in patients treated with ACTH.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnostic imaging. Adrenocorticotropic Hormone / therapeutic use. Hormones / therapeutic use. Neuroblastoma / diagnostic imaging. Opsoclonus-Myoclonus Syndrome / diagnostic imaging. Opsoclonus-Myoclonus Syndrome / drug therapy


20. Johnsen JI, Segerström L, Orrego A, Elfman L, Henriksson M, Kågedal B, Eksborg S, Sveinbjörnsson B, Kogner P: Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene; 2008 May 1;27(20):2910-22
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  • [Title] Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo.
  • In this study we investigated the phosphorylation status of key proteins in the PI3K/AKT/mTOR pathway and the effects of the mTOR inhibitors rapamycin and CCI-779 on neuroblastoma tumorigenesis.
  • Significant expression of activated AKT and mTOR were detected in all primary neuroblastoma tissue samples investigated, but not in non-malignant adrenal medullas. mTOR inhibitors showed antiproliferative effects on neuroblastoma cells in vitro.
  • Neuroblastoma cell lines expressing high levels of MYCN were significantly more sensitive to mTOR inhibitors compared to cell lines expressing low MYCN levels.
  • Established neuroblastoma tumors treated with mTOR inhibitors in vivo showed increased apoptosis, decreased proliferation and inhibition of angiogenesis.
  • [MeSH-major] Antibiotics, Antineoplastic / pharmacology. Down-Regulation / drug effects. Growth Inhibitors / pharmacology. Neuroblastoma / pathology. Nuclear Proteins / antagonists & inhibitors. Nuclear Proteins / genetics. Oncogene Proteins / antagonists & inhibitors. Oncogene Proteins / genetics. Protein Kinases / metabolism


21. Sveinbjörnsson B, Rasmuson A, Baryawno N, Wan M, Pettersen I, Ponthan F, Orrego A, Haeggström JZ, Johnsen JI, Kogner P: Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy. FASEB J; 2008 Oct;22(10):3525-36
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  • [Title] Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
  • In this study, we examined the expression and significance of components within the 5-LO pathway in human neuroblastoma, an embryonal tumor of the sympathetic nervous system.
  • High expression of 5-LO, 5-LO-activating protein (FLAP), leukotriene A(4) hydrolase, leukotriene C(4) synthase, and leukotriene receptors was detected in a majority of primary neuroblastoma tumors and all cell lines investigated.
  • Expression of 5-LO and FLAP was evident in tumor cells but not in nonmalignant adrenal medulla where neuroblastomas typically arise.
  • Moreover, neuroblastoma cells produce leukotrienes, and stimulation of neuroblastoma cells with leukotrienes increased neuroblastoma cell viability.
  • Inhibitors of 5-LO (AA-861), FLAP (MK-886), or the leukotriene receptor antagonist montelukast inhibited neuroblastoma cell growth by induction of G(1)-cell cycle arrest and apoptosis.
  • Similarly, specific 5-LO and leukotriene receptor silencing by small interfering RNA decreased neuroblastoma cell growth.
  • These findings provide new insights into the pathobiology of neuroblastoma, and the use of leukotriene pathway inhibitors as a novel adjuvant therapy for children with neuroblastoma warrants further consideration.
  • [MeSH-major] Leukotrienes / biosynthesis. Neuroblastoma / metabolism. Neuroblastoma / pathology

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  • (PMID = 18591367.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 5-Lipoxygenase-Activating Proteins; 0 / ALOX5AP protein, human; 0 / Carrier Proteins; 0 / Enzyme Inhibitors; 0 / Leukotriene Antagonists; 0 / Leukotrienes; 0 / Lipoxygenase Inhibitors; 0 / Membrane Proteins; 0 / Receptors, Leukotriene; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; EC 2.5.1.18 / Glutathione Transferase; EC 3.3.2.- / Epoxide Hydrolases; EC 3.3.2.- / leukotriene A4 hydrolase; EC 4.4.1.20 / leukotriene-C4 synthase
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22. Nishio N, Mimaya J, Nara T, Takashima Y, Horikoshi Y, Urushihara N, Hasegawa S, Aoki K, Hamasaki M: Results for 79 patients with neuroblastoma detected through mass screening at 6 months of age in a single institute. Pediatr Int; 2006 Dec;48(6):531-5
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  • [Title] Results for 79 patients with neuroblastoma detected through mass screening at 6 months of age in a single institute.
  • BACKGROUND: In Japan, mass screening for neuroblastoma has been performed at 6 months of age to improve the prognosis of this condition for more than 20 years.
  • METHODS: The authors established non-treated observation criteria in 1997 and criteria for observation of residual tumor after first-line chemotherapy in 1999, and have made an effort to reduce the intensity of medical treatment for neuroblastoma.
  • The authors examined outcomes of 79 patients who were found in the Shizuoka neuroblastoma mass screening at 6 months of age and who received medical treatment or underwent observation in Shizuoka Children's Hospital, Shizuoka, Japan, between December 1981 and December 2004.
  • None of the patients died due to progression of neuroblastoma.
  • [MeSH-major] Mass Screening. Neuroblastoma / diagnosis. Neuroblastoma / therapy
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / urine. Homovanillic Acid / urine. Humans. Infant. Japan / epidemiology. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / therapy. Neoplasm Regression, Spontaneous. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Survival Rate. Treatment Outcome. Vanilmandelic Acid / urine

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  • (PMID = 17168969.001).
  • [ISSN] 1328-8067
  • [Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society
  • [ISO-abbreviation] Pediatr Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 55-10-7 / Vanilmandelic Acid; X77S6GMS36 / Homovanillic Acid
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23. Margetts CD, Morris M, Astuti D, Gentle DC, Cascon A, McRonald FE, Catchpoole D, Robledo M, Neumann HP, Latif F, Maher ER: Evaluation of a functional epigenetic approach to identify promoter region methylation in phaeochromocytoma and neuroblastoma. Endocr Relat Cancer; 2008 Sep;15(3):777-86
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  • [Title] Evaluation of a functional epigenetic approach to identify promoter region methylation in phaeochromocytoma and neuroblastoma.
  • Previously, we found considerable overlap between patterns of promoter region tumour suppressor gene (TSG) hypermethylation in two neural crest tumours, neuroblastoma and phaeochromocytoma.
  • In order to identify candidate biomarkers and epigenetically inactivated TSGs in phaeochromocytoma and neuroblastoma, we characterised changes in gene expression in three neuroblastoma cell lines after treatment with the demethylating agent 5-azacytidine.
  • Two of the genes, epithelial membrane protein 3 (EMP3) and HSP47, demonstrated significantly more frequent methylation in neuroblastoma than phaeochromocytoma.


24. Arscott WT, LaBauve AE, May V, Wesley UV: Suppression of neuroblastoma growth by dipeptidyl peptidase IV: relevance of chemokine regulation and caspase activation. Oncogene; 2009 Jan 29;28(4):479-91
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  • [Title] Suppression of neuroblastoma growth by dipeptidyl peptidase IV: relevance of chemokine regulation and caspase activation.
  • Imbalanced protease expression and activities may contribute to the development of cancers, including neuroblastoma (NB).
  • Our studies show that DPPIV is expressed in normal neural crest-derived structures, including superior cervical and dorsal root ganglion cells, sciatic nerve, and in adrenal glands, but its expression is greatly decreased or lost in cells derived from NB, their malignant counterpart.

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  • (PMID = 18978811.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR016435; United States / NCRR NIH HHS / RR / RR016435-076892; United States / NCRR NIH HHS / RR / 2 P20 RR016435-P4Y6; United States / NCRR NIH HHS / RR / P20 RR016435-076892
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Chemokine CXCL12; 0 / Cxcr4 protein, rat; 0 / Growth Substances; 0 / Microtubule-Associated Proteins; 0 / Mtap2 protein, mouse; 0 / Mtap2 protein, rat; 0 / Receptors, CXCR4; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.4.14.5 / Dipeptidyl Peptidase 4; EC 3.4.22.- / Caspases; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Other-IDs] NLM/ NIHMS71578; NLM/ PMC2633428
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25. Baldisserotto M, Peletti AB, Angelo de Araújo M, Pertence AP, Dora MD, Maciel EO, Gaiger AM: Beckwith-Wiedemann syndrome and bilateral adrenal pheochromocytoma: sonography and MRI findings. Pediatr Radiol; 2005 Nov;35(11):1132-4
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  • [Title] Beckwith-Wiedemann syndrome and bilateral adrenal pheochromocytoma: sonography and MRI findings.
  • The association of this syndrome with malignant tumors is well documented.
  • We report a child with this syndrome associated with bilateral adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnostic imaging. Adrenal Gland Neoplasms / pathology. Beckwith-Wiedemann Syndrome / diagnostic imaging. Beckwith-Wiedemann Syndrome / pathology. Pheochromocytoma / diagnostic imaging. Pheochromocytoma / pathology
  • [MeSH-minor] Carcinoma / diagnostic imaging. Carcinoma / pathology. Child. Diagnosis, Differential. Humans. Magnetic Resonance Imaging / methods. Male. Neuroblastoma / diagnostic imaging. Neuroblastoma / pathology. Radiography. Severity of Illness Index. Ultrasonography / methods


26. Araujo Júnior E, Sanchez Ayub E, Costa Santos EM, Moraes DJ, Rodrigues Pires C, Filho Sebastião MZ: [Prenatal ultrasound diagnosis of adrenal neuroblastoma]. Ginecol Obstet Mex; 2005 Aug;73(8):451-5
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  • [Title] [Prenatal ultrasound diagnosis of adrenal neuroblastoma].
  • [Transliterated title] Diagnóstico prenatal ultrasonográfico de neuroblastoma adrenal.
  • Neuroblastoma is the most frequent solid malignant tumor in the neonatal period; however, its diagnosis is very difficult in the prenatal one.
  • The antenatal ultrasound diagnosis is possible by finding a mixed mass in the adrenal gland.
  • We report a case of a bilateral adrenal neuroblastoma diagnosed by antenatal ultrasonography at the 29th week of gestation.
  • [MeSH-major] Adrenal Gland Neoplasms / ultrasonography. Fetal Diseases / ultrasonography. Neuroblastoma / ultrasonography. Ultrasonography, Prenatal


27. Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T: Concordance for neuroblastoma in monozygotic twins: case report and review of the literature. J Pediatr Surg; 2010 Dec;45(12):2312-6
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  • [Title] Concordance for neuroblastoma in monozygotic twins: case report and review of the literature.
  • Resection of an adrenal tumor and a liver tumor biopsy were performed.
  • Screening by abdominal ultrasonography showed multiple masses in the liver but no adrenal mass.
  • All primary tumor and liver tumor specimens from twin 2 and the liver tumor of twin 1 had the same histologic classification of neuroblastoma and nearly identical genetic aberrations, including a chromosome gain or loss using array-comparative genomic hybridization.
  • In the literature, 9 pairs of concordant twin neuroblastomas, including the current twin, have been presented; and the clinical findings of 5 twin pairs may represent placental metastases from one twin with congenital neuroblastoma to the other twin.
  • This study is the first report presenting the possibility of twin-to-twin metastasis in monozygotic twins with neuroblastoma based on an analysis of the clinical features and genetic aberrations.
  • [MeSH-major] Adrenal Gland Neoplasms / embryology. Diseases in Twins / embryology. Fetofetal Transfusion. Liver Neoplasms / secondary. Neuroblastoma / embryology. Neuroblastoma / secondary. Placenta / pathology. Twins, Monozygotic

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21129536.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 35MRW7B4AD / 3-Iodobenzylguanidine; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide
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28. Tanaka M, Kato K, Gomi K, Matsumoto M, Kudo H, Shinkai M, Ohama Y, Kigasawa H, Tanaka Y: Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma. Am J Surg Pathol; 2009 Sep;33(9):1416-20
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  • [Title] Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma.
  • We report a case of perivascular epithelioid cell tumor (PEComa) with an SFPQ/PSF-TFE3 gene fusion in a 14-year-old girl treated for adrenal neuroblastoma for 4 years.
  • Imaging studies revealed a tumor in the wall of the sigmoid colon, which was radiologically different from the neuroblastoma, together with several inguinal and cervical lymph node metastases of the neuroblastoma.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Colonic Neoplasms / pathology. Neuroblastoma / secondary. Perivascular Epithelioid Cell Neoplasms / pathology

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  • (PMID = 19606011.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / PTB-associated splicing factor; 0 / RNA-Binding Proteins; 0 / TFE3 protein, human
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29. El-Maghraby T: 131I-MIBG in the diagnosis of primary and metastatic neuroblastoma. Gulf J Oncolog; 2007 Jul;(2):33-41
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  • [Title] 131I-MIBG in the diagnosis of primary and metastatic neuroblastoma.
  • OBJECTIVE: Neuroblastoma is the third most common malignancy of childhood.
  • 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging.
  • The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease.
  • METHODS: Twenty six patients provisionally diagnosed by clinical and imaging criteria to have neuroblastoma were included.
  • On histopathologic verification 5 of these 26 patients were rediagnosed as non-neuroblastoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Iodine Radioisotopes. Neuroblastoma / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radionuclide imaging. Bone Marrow Neoplasms / radionuclide imaging. Bone Marrow Neoplasms / secondary. Brain Neoplasms / radionuclide imaging. Brain Neoplasms / secondary. Child. Child, Preschool. Female. Humans. Infant. Liver Neoplasms / radionuclide imaging. Liver Neoplasms / secondary. Male. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / radionuclide imaging. Neoplasm Staging. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / radionuclide imaging. Spinal Neoplasms / pathology. Spinal Neoplasms / radionuclide imaging. Technetium Tc 99m Medronate

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  • (PMID = 20084722.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Kuwait
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine; X89XV46R07 / Technetium Tc 99m Medronate
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30. Bao AM, Fischer DF, Wu YH, Hol EM, Balesar R, Unmehopa UA, Zhou JN, Swaab DF: A direct androgenic involvement in the expression of human corticotropin-releasing hormone. Mol Psychiatry; 2006 Jun;11(6):567-76
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  • We investigated the possibility of a direct action of androgens on the expression of the human corticotropin-releasing hormone (CRH), which plays a central role in the hypothalamic-pituitary-adrenal (HPA)-axis.
  • A potential androgen-responsive element (ARE) in the human CRH promoter was subsequently analyzed with bandshifts and cotransfections in neuroblastoma cells.

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  • (PMID = 16446741.001).
  • [ISSN] 1359-4184
  • [Journal-full-title] Molecular psychiatry
  • [ISO-abbreviation] Mol. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Androgen; 3XMK78S47O / Testosterone; 9015-71-8 / Corticotropin-Releasing Hormone
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31. Escobar MA, Grosfeld JL, Powell RL, West KW, Scherer LR 3rd, Fallon RJ, Rescorla FJ: Long-term outcomes in patients with stage IV neuroblastoma. J Pediatr Surg; 2006 Feb;41(2):377-81
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  • [Title] Long-term outcomes in patients with stage IV neuroblastoma.
  • AIM OF STUDY: Long-term outcome studies in survivors with stage IV neuroblastoma (NB) are sparse.
  • Age at diagnosis was 29.1 +/- 31.7 months in survivors.
  • Primary tumor sites were adrenal (35), retroperitoneal (11), mediastinal (3), pelvic (2), and no primary with tumor metastases identified (1).
  • [MeSH-major] Neuroblastoma / pathology. Neuroblastoma / therapy. Survivors
  • [MeSH-minor] Child, Preschool. Female. Humans. Male. Neoplasm Staging. Retrospective Studies. Time Factors

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  • (PMID = 16481255.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Iwase K, Nagasaka A, Kato K, Itoh A, Jimbo S, Hibi Y, Kobayashi N, Yamamoto H, Seko T, Miura K: Cu/Zn- and Mn-superoxide dismutase distribution and concentration in adrenal tumors. J Surg Res; 2006 Sep;135(1):150-5
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  • [Title] Cu/Zn- and Mn-superoxide dismutase distribution and concentration in adrenal tumors.
  • The tissue distribution of Cu/Zn- and Mn-superoxide dismutases (SOD) in adrenal tumors was studied by an immunohistochemical technique, and the concentrations of both SODs were measured by a sensitive sandwich enzyme immunoassay technique.
  • In the normal adrenal gland, both Cu/Zn- and Mn-SODs were localized predominantly in the reticular zone of the cortex.
  • In different adrenal tumors, the localization of both stained SODs reflected the origin of the tumor cell.
  • The concentrations of both SODs in the tissues of medullary tumors were lower than those in the normal adrenal gland and adrenocortical adenomas.
  • The concentration of Cu/Zn-SOD in the tumor tissue of Cushing's syndrome adenoma was higher, and that of Mn-SOD was lower than the concentrations in the normal adrenal gland.
  • The ratio of the tissue concentrations of Mn-SOD to Cu/Zn-SOD was lower in adrenal medullary tumors and Cushing's syndrome adenomas than in the normal adrenal gland and primary aldosteronism adenomas, indicating the predominance of Cu/Zn-SOD in the former, and Mn-SOD in the latter.
  • These data suggest that the localization of Cu/Zn- and Mn-SODs in adrenal tissues reflects the specificity of the adrenal cells that produce the tissue-specific hormones.
  • An investigation of changes in these enzymes in adrenal tumors may also provide useful information on adrenal tumor cell differentiation.
  • [MeSH-major] Adrenal Cortex / enzymology. Adrenal Cortex Neoplasms / metabolism. Adrenocortical Adenoma / metabolism. Superoxide Dismutase / metabolism
  • [MeSH-minor] Cell Differentiation. Ganglioneuroma / metabolism. Ganglioneuroma / pathology. Humans. Immunoenzyme Techniques. Immunohistochemistry. Neuroblastoma / metabolism. Neuroblastoma / pathology. Pheochromocytoma / metabolism. Pheochromocytoma / pathology

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  • (PMID = 16780879.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.15.1.1 / Superoxide Dismutase
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33. Boller D, Schramm A, Doepfner KT, Shalaby T, von Bueren AO, Eggert A, Grotzer MA, Arcaro A: Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells. Clin Cancer Res; 2008 Feb 15;14(4):1172-81
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  • [Title] Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.
  • PURPOSE: The phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in human cancer and plays a crucial role in neuroblastoma biology.
  • We were interested in gaining further insight into the potential of targeting PI3K/Akt signaling as a novel antiproliferative approach in neuroblastoma.
  • RESULTS: Overexpression of the catalytic p110delta and regulatory p85alpha isoforms was detected in a panel of primary neuroblastoma samples and cell lines, compared with normal adrenal gland tissue.
  • CONCLUSIONS: Together, our data reveal a novel function of p110delta in neuroblastoma growth and survival.
  • [MeSH-major] Cell Proliferation. Cell Survival / physiology. Neuroblastoma / enzymology. Phosphatidylinositol 3-Kinases / metabolism


34. Deeg KH, Dachert C, Glöckel U, Langer T: The different features of congenital neuroblastomas: report about the sonographic diagnosis of three cases. Ultraschall Med; 2007 Jun;28(3):313-20
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  • [Title] The different features of congenital neuroblastomas: report about the sonographic diagnosis of three cases.
  • We report on three infants with congenital neuroblastoma.
  • Diagnosis was established by ultrasonography showing hypoechoic tumours without significant calcifications.
  • Colour coded Doppler sonography revealed perfusion of the tumours distinguishing the suprarenal masses from adrenal haemorrhage.
  • The right-sided mediastinal neuroblastoma showed infiltration of the intervertebral foramina and spinal canal without spinal cord compression.
  • [MeSH-major] Abdominal Neoplasms / ultrasonography. Adrenal Gland Neoplasms / ultrasonography. Liver Neoplasms / ultrasonography. Neuroblastoma / ultrasonography

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  • (PMID = 17262249.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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35. Jacob ES, Varghese RG, Toi PC, Bhaskaran R, Rai R: Congenital neuroblastoma with liver metastasis presenting with Hashimoto Pritzker disease. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):374-6
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  • [Title] Congenital neuroblastoma with liver metastasis presenting with Hashimoto Pritzker disease.
  • She was earlier diagnosed to have neuroblastoma of the adrenal gland which had metastasized to the liver.
  • [MeSH-major] Infant, Newborn, Diseases / diagnosis. Infant, Newborn, Diseases / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Neuroblastoma / diagnosis. Neuroblastoma / pathology
  • [MeSH-minor] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Female. Histocytochemistry. Humans. Infant. Infant, Newborn. Pregnancy. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Neoplasms / secondary. Young Adult


36. Yoshida H, Nakamura H, Ono T, Kushikata T, Ishihara H, Hirota K: [Safe management of anesthesia with total intravenous anesthesia using propofol, fentanyl and ketamine for a patient treated with intraoperative radiotherapy]. Masui; 2006 May;55(5):614-6
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  • A 3-year-old girl with neuroblastoma was scheduled for intraoperative radiation therapy.
  • [MeSH-major] Adrenal Gland Neoplasms / radiotherapy. Anesthesia, Intravenous / methods. Intraoperative Care

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  • (PMID = 16715919.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 690G0D6V8H / Ketamine; UF599785JZ / Fentanyl; YI7VU623SF / Propofol
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37. Quackenbush KE, Luna-Fineman S, Magee JF, Gundogan M, Golobi M, Irie T, Fernandez CV: Neuroblastoma involvement of the falx cerebri. Pediatr Blood Cancer; 2009 Dec 15;53(7):1337-9
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  • [Title] Neuroblastoma involvement of the falx cerebri.
  • Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare.
  • The falx is derived from the neural crest and thus may be a location for primary neuroblastoma.
  • Management of neuroblastoma in this location is potentially challenging.
  • We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dura Mater / pathology. Meningeal Neoplasms / secondary. Neuroblastoma / secondary
  • [MeSH-minor] Adrenalectomy. Carboplatin / administration & dosage. Cell Lineage. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Infant. Infant, Newborn. Male. Microphthalmia-Associated Transcription Factor / genetics. Neoplasm Staging. Neural Crest. Pulmonary Veins / abnormalities. Remission Induction. Skin Neoplasms / drug therapy. Skin Neoplasms / secondary. Waardenburg Syndrome / complications. Waardenburg Syndrome / genetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19821537.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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38. Al-Shammari NF, Redha E, Al Hajeri MH: Cervical neonatal neuroblastoma with recurrent SVT. Gulf J Oncolog; 2009 Jul;(6):45-57
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  • [Title] Cervical neonatal neuroblastoma with recurrent SVT.
  • Neuroblastoma is the most common extracranial solid tumor of childhood and the third most common paediatric malignancy after leukemia and central nervous system (CNS) tumors.
  • Seventy five percent of neuroblastoma arise in the abdomen and pelvis, 20% in the thorax and 5% in the neck.
  • The median age at diagnosis is 22 months.
  • They occur most commonly in the adrenal medulla (35%).
  • Neuroblastomas also occur as primary tumors in the extra-adrenal retroperitoneum in 30% of cases, in the posterior mediastinum in 20% of cases , in the neck up to 5% of cases and in the pelvis in 5% of cases.
  • [MeSH-major] Head and Neck Neoplasms / complications. Neuroblastoma / complications. Tachycardia, Supraventricular / etiology


39. Ilias I, Pacak K: Diagnosis and management of tumors of the adrenal medulla. Horm Metab Res; 2005 Dec;37(12):717-21
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  • [Title] Diagnosis and management of tumors of the adrenal medulla.
  • The adrenal medulla consists of chromaffin cells, the site of catecholamine biosynthesis.
  • Pheochromocytomas are chromaffin-cell tumors; 80-85 % arise from the adrenal medulla and 15-20 % arise from extra-adrenal chromaffin tissues (paragangliomas).
  • Pheochromocytomas account for 6.5 % of incidentally discovered adrenal tumors; they are found in 50 % of patients with multiple endocrine neoplasia 2A (MEN 2A) and 5-25 % of patients with von Hippel-Lindau (VHL) syndrome.
  • The diagnosis of pheochromocytoma should first be established biochemically by measuring plasma free metanephrines (the measurement of urinary fractionated metanephrines is the second choice).
  • Measurements of homovanillic acid (HVA), norepinephrine and vanilmandelic acid (VMA) in urine are a necessity in patients with suspected neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Adrenal Medulla / physiopathology. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / therapy
  • [MeSH-minor] Humans. Multiple Endocrine Neoplasia Type 2a / diagnosis. Multiple Endocrine Neoplasia Type 2a / therapy. Neuroblastoma / diagnosis. Neuroblastoma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy. Prognosis

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  • (PMID = 16372223.001).
  • [ISSN] 0018-5043
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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40. Zheng LD, Tong QS, Tang ST, Du ZY, Liu Y, Jiang GS, Cai JB: Expression and clinical significance of heparanase in neuroblastoma. World J Pediatr; 2009 Aug;5(3):206-10
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  • [Title] Expression and clinical significance of heparanase in neuroblastoma.
  • However, the expression of HPA in neuroblastoma (NB), one of the most common extra cranial solid tumors in children, remains unknown.
  • The relationships among HPA expression, international neuroblastoma staging system (INSS) stages, histopathological classification, and postoperative survival of the NB patients were analyzed.
  • RESULTS: The expression rate of HPA in NB was 61.9% (26/42), mainly in the cytoplasm of neuroblastoma cells.
  • [MeSH-major] Adrenal Gland Neoplasms / enzymology. Glucuronidase / metabolism. Neuroblastoma / enzymology

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  • (PMID = 19693465.001).
  • [ISSN] 1708-8569
  • [Journal-full-title] World journal of pediatrics : WJP
  • [ISO-abbreviation] World J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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41. Kumar J, Kumar A, Seith A, Agarwala S, Bakhshi S: Multifocal neuroblastoma with stage IV disease in an 8-year-old boy. J Pediatr Hematol Oncol; 2008 May;30(5):408-9
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  • [Title] Multifocal neuroblastoma with stage IV disease in an 8-year-old boy.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neuroblastoma / pathology
  • [MeSH-minor] Biopsy, Needle. Child. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging

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  • [CommentOn] J Pediatr Hematol Oncol. 2007 Sep;29(9):652-5 [17805045.001]
  • (PMID = 18458582.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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42. Miyoshi T, Tomita K: [Metanephrine (M), normetanephrine (NM), and fractionated metanephrines]. Nihon Rinsho; 2010 Jul;68 Suppl 7:422-5
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  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / diagnosis. Adult. Child. Child, Preschool. Humans. Infant. Neuroblastoma / diagnosis. Peripheral Nervous System Neoplasms. Pheochromocytoma / diagnosis. Sympathetic Nervous System

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  • (PMID = 20963883.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0J45DE6B88 / Normetanephrine; 5001-33-2 / Metanephrine
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43. Franzius C, Schmidt M, Hero B, Pfluger T, Hahn K, Deutsche Gesellschaft für Nuklearmedizin (DGN), Neuroblastom-Studiengruppe der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH): [Procedure guidelines for MIBG-scintigraphy in children]. Nuklearmedizin; 2008;47(3):132-8
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  • For the first time this guideline was generated in consensus with the neuroblastoma study group of the Association of Paediatric Haematologie and Oncology (GPOH) with the result of an interdisciplinary recommendation.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Gland Neoplasms / radionuclide imaging. Neuroblastoma / radionuclide imaging. Pheochromocytoma / radionuclide imaging. Tomography, Emission-Computed, Single-Photon / methods

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  • (PMID = 18493694.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 35MRW7B4AD / 3-Iodobenzylguanidine
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44. Stefanowicz J, Izycka-Swieszewska E, Drozyńska E, Pienczk J, Połczyńska K, Czauderna P, Sierota D, Bień E, Stachowicz-Stencel T, Kosiak W, Balcerska A: Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics. Folia Neuropathol; 2008;46(3):176-85
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  • [Title] Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics.
  • The suprarenal gland was the primary localization of the tumour in 3 of the children and in one the tumour was located in the retroperitoneal area.
  • The group included two ganglioneuroblastomas, one ganglioneuroma and one differentiating neuroblastoma.
  • Children with OMA and neuroblastoma despite a good oncological prognosis often present permanent neurological and developmental deficits.


45. Zhang N, Lin LK: Presumed primary orbital neuroblastoma in a 20-month-old female. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):383-5
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  • [Title] Presumed primary orbital neuroblastoma in a 20-month-old female.
  • Neuroblastoma is the most common malignant disease of childhood, and it often arises from either the adrenal gland or along the sympathetic chain.
  • The authors report a case of a 20-month-old female with a presumed primary neuroblastoma of the orbit.
  • To the best of the authors' knowledge, primary orbital neuroblastoma has only been previously reported once in children, although it has been reported twice in adults.
  • [MeSH-major] Neuroblastoma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bone Marrow Transplantation. Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 20622692.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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46. Chiung YM, Kao YY, Chang WF, Yao CW, Liu PS: Toluene diisocyanate (TDI) induces calcium elevation and interleukine-4 (IL-4) release - early responses upon TDI stimulation. J Toxicol Sci; 2010 Apr;35(2):197-207
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  • We used human lung epithelial cell line H1355, human T-cell line Jurkat, and human neuroblastoma SH-SY5Y cells to present the kinds of cells existing in airway.
  • Results show that TDI induced an elevation in [Ca(2+)](c )in those cell lines and two primary isolated cells, bovine adrenal chromaffin cells and human white blood cells.

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  • (PMID = 20371970.001).
  • [ISSN] 1880-3989
  • [Journal-full-title] The Journal of toxicological sciences
  • [ISO-abbreviation] J Toxicol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / RNA, Messenger; 17X7AFZ1GH / Toluene 2,4-Diisocyanate; 207137-56-2 / Interleukin-4; SY7Q814VUP / Calcium
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47. Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR: Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res; 2007 Dec 1;67(23):11234-43
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  • [Title] Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell.
  • Neuroblastoma is a heterogeneous pediatric tumor thought to arise from the embryonic neural crest.
  • We have isolated and characterized putative tumor-initiating cells from 16 tumors and bone marrow metastases from patients in all neuroblastoma risk groups.
  • Dissociated cells from tumors or bone marrow grew as spheres in conditions used to culture neural crest stem cells, were capable of self-renewal, and exhibited chromosomal aberrations typical of neuroblastoma.
  • As few as 10 passaged tumor sphere cells from aggressive neuroblastoma injected orthotopically into severe combined immunodeficient/Beige mice formed large neuroblastoma tumors that metastasized to liver, spleen, contralateral adrenal and kidney, and lung.
  • Our data indicate that high-risk neuroblastoma contains a cell with cancer stem cell properties that is enriched in tumor-initiating capacity.
  • These cells may serve as a model system to identify the molecular determinants of neuroblastoma and to develop new therapeutic strategies for this tumor.
  • [MeSH-major] Bone Marrow Neoplasms / pathology. Bone Marrow Neoplasms / secondary. Cell Differentiation. Neoplastic Stem Cells / pathology. Neuroblastoma / pathology

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  • [CommentIn] Cancer Res. 2012 Feb 1;72(3):821-2; author reply 823 [22298597.001]
  • (PMID = 18056449.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Gorman MP: Update on diagnosis, treatment, and prognosis in opsoclonus-myoclonus-ataxia syndrome. Curr Opin Pediatr; 2010 Dec;22(6):745-50
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  • [Title] Update on diagnosis, treatment, and prognosis in opsoclonus-myoclonus-ataxia syndrome.
  • PURPOSE OF REVIEW: Opsoclonus-myoclonus-ataxia syndrome (OMS) is a severe autoimmune central nervous system disorder, which predominantly affects young children and causes lifelong neurological disability.
  • RECENT FINDINGS: Appreciation of the spectrum of clinical presentations of OMS, awareness of common misdiagnoses, and utilization of diagnostic criteria may facilitate the timely diagnosis of OMS.
  • Approximately 50% of patients have an associated neuroblastoma, which may escape detection by traditional methods and require MRI or computed tomography of the torso for diagnosis.
  • SUMMARY: The diagnosis of OMS requires a high level of suspicion and a systematic approach for diagnostic testing, particularly for neuroblastoma.
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Humans. Treatment Outcome


49. Ozono R: [Dopamine]. Nihon Rinsho; 2005 Aug;63 Suppl 8:388-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Autonomic Nervous System Diseases / diagnosis. Autonomic Nervous System Diseases / genetics. Biomarkers / blood. Biomarkers / urine. Chromatography, High Pressure Liquid. Dopamine beta-Hydroxylase / deficiency. Humans. Hypertension / diagnosis. Hypertension / etiology. Menkes Kinky Hair Syndrome / diagnosis. Neuroblastoma / diagnosis. Parkinson Disease / diagnosis. Pheochromocytoma / diagnosis. Reference Values. Shy-Drager Syndrome / diagnosis. Sodium, Dietary / adverse effects. Specimen Handling

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  • (PMID = 16149536.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Sodium, Dietary; EC 1.14.17.1 / Dopamine beta-Hydroxylase; VTD58H1Z2X / Dopamine
  • [Number-of-references] 8
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50. Jacobson AF, Deng H, Lombard J, Lessig HJ, Black RR: 123I-meta-iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: results of a meta-analysis. J Clin Endocrinol Metab; 2010 Jun;95(6):2596-606
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  • [Title] 123I-meta-iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: results of a meta-analysis.
  • OBJECTIVE: A meta-analysis was performed to obtain best estimates of performance characteristics of (123)I-mIBG imaging for the two most common applications, evaluation of patients with neuroblastoma and pheochromocytoma.
  • DATA SYNTHESIS: Sensitivity of (123)I-mIBG scans for detection of neuroblastoma was 97% [95% confidence interval (CI), 95 to 99%]; data were insufficient to estimate specificity.
  • CONCLUSION: Based upon the literature, (123)I-mIBG scintigraphy has sensitivity and specificity greater than 90% for detection of neuroblastoma and pheochromocytoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Gland Neoplasms / radionuclide imaging. Neuroblastoma / radionuclide imaging. Pheochromocytoma / radionuclide imaging. Radiopharmaceuticals


51. Singh M, Arora P, Singh S, Bohara S, Khurana N, Zutshi V, Kumar R: Adult neuroblastoma of the ovary: a rare tumor with review of literature. J Cancer Res Ther; 2010 Jul-Sep;6(3):367-9
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  • [Title] Adult neuroblastoma of the ovary: a rare tumor with review of literature.
  • Neuroblastoma is a tumor of pediatric age group and is extremely rare in adults.
  • Common sites involved in adults are almost similar to that seen in children like retroperitoneum, adrenal gland, pelvis and mediastinum.
  • Ovarian neuroblastoma has never been reported in the literature before.
  • We, hereby, present a case of a 38-year-old lady with bilateral ovarian neuroblastoma diagnosed as Krukenberg's tumor clinicoradiologically.
  • [MeSH-major] Neuroblastoma / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 21119280.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
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52. Brankov O, Drebov R, Stoilov S, Panov M, Penushliev T, Georgiev Ts: [Malignant neurogenic tumors with retroperitoneal and mediastinal locations in infants]. Khirurgiia (Sofiia); 2007;(1-2):5-8
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  • [Title] [Malignant neurogenic tumors with retroperitoneal and mediastinal locations in infants].
  • INTRODUCTION: Malignant neurogenic tumors /MNT/ are the third by frequency malignancies in children with mainly localization in the retroperitoneal space and posterior mediastinum.
  • Most of them have an unfavorable histological variant and affect predominantly the adrenal glands.
  • [MeSH-major] Mediastinal Neoplasms. Neuroblastoma. Retroperitoneal Neoplasms
  • [MeSH-minor] Child, Preschool. Disease-Free Survival. Female. Humans. Infant. Male. Neoplasm Staging

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  • (PMID = 18461028.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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53. Freidl T, Lackner H, Huber J, Sovinz P, Moser A, Schroettner B, Schwinger W, Urban C: Focal nodular hyperplasia in children following treatment of hemato-oncologic diseases. Klin Padiatr; 2008 Nov-Dec;220(6):384-7
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  • Differential diagnosis to other focal liver lesions especially to metastases is often difficult.
  • PATIENTS AND METHODS: We report on four children (female n=2, male n=2; age at initial diagnosis: 9 months, 20 months, 11.5 and 14 years) with different non-hepatic primary tumors (gastrointestinal stroma-tumor, neuroblastoma (n=2) and nephroblastoma) who developed focal liver lesions 2, 2.5, 3 and 8 years after successful treatment of their primary malignancy, respectively.
  • RESULTS: Diagnosis of focal nodular hyperplasia was established by sonography, computed tomography and magnetic resonance imaging.
  • CONCLUSION: Diagnosis of FNH has to be included in the differential diagnosis of uncertain liver lesions.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Focal Nodular Hyperplasia / diagnosis. Gastrointestinal Stromal Tumors / secondary. Kidney Neoplasms / therapy. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Neuroblastoma / secondary. Stomach Neoplasms / therapy. Wilms Tumor / secondary
  • [MeSH-minor] Adolescent. Biopsy, Needle. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant. Liver / pathology. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed. Ultrasonography


54. Yatabe J, Sanada H: [3,4-Dihydroxyphenyl alanine (DOPA)]. Nihon Rinsho; 2005 Aug;63 Suppl 8:380-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Biomarkers / analysis. Chromatography, High Pressure Liquid. Humans. Melanoma / diagnosis. Nervous System Neoplasms / diagnosis. Neuroblastoma / diagnosis. Parkinson Disease / diagnosis. Pheochromocytoma / diagnosis. Reference Values. Specimen Handling

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  • (PMID = 16149534.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 63-84-3 / Dihydroxyphenylalanine
  • [Number-of-references] 10
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55. Tatekawa Y, Muraji T, Nishijima E, Yoshida M, Tsugawa C: Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report. J Pediatr Surg; 2006 Feb;41(2):443-5
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  • [Title] Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report.
  • Screening abdominal ultrasonography showed a 6-cm-sized mass in the left adrenal gland.
  • Metaiodobenzyl guanidine I 123 scintigram, abdominal computed tomography, and abdominal magnetic resonance imaging revealed only left adrenal tumor with no metastasis.
  • Left adrenalectomy was performed transperitoneally, and histopathological diagnosis was an adrenal composite pheochromocytoma associated with neuroblastoma.
  • Immunoreactivity for vimentin was positive in pheochromocytoma, which was negative in neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neuroblastoma / pathology. Pheochromocytoma / pathology


56. Horiuchi A, Watanabe Y, Miyauchi K, Kawachi K, Ishida Y, Tokuda K, Tauchi H: Prenatally detected cystic adrenal neuroblastoma. Pediatr Int; 2008 Feb;50(1):130-1
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  • [Title] Prenatally detected cystic adrenal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Cysts / pathology. Female. Humans. Infant, Newborn. Male. Pregnancy. Prenatal Diagnosis

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  • (PMID = 18279224.001).
  • [ISSN] 1328-8067
  • [Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society
  • [ISO-abbreviation] Pediatr Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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57. Gutweiler JR, Yu DC, Kim HB, Kozakewich HP, Marcus KJ, Shamberger RC, Weldon CB: Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma. J Pediatr Surg; 2008 Dec;43(12):2297-300
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  • [Title] Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma.
  • Although there is no evidence for malignant degeneration, FNH can occur adjacent to a malignancy.
  • Here, the case of a 4-year-old boy with a hepatic mass and history of stage IV neuroblastoma is presented.
  • However, after left lateral segmentectomy, pathologic examination revealed a malignant tumor most consistent with small cell undifferentiated hepatoblastoma as well as 3 foci of FNH in the surrounding parenchyma.
  • [MeSH-major] Adrenal Gland Neoplasms. Focal Nodular Hyperplasia / etiology. Hepatoblastoma / diagnosis. Liver Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Neuroblastoma


58. Messina M, Di Maggio G, Garzi A, Molinaro F, Amato G, Ferrara F: [Neonatal neuroblastoma and prenatal diagnosis]. Minerva Pediatr; 2009 Jun;61(3):349-54
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  • [Title] [Neonatal neuroblastoma and prenatal diagnosis].
  • [Transliterated title] Neuroblastoma neonatale e diagnosi pre-natale.
  • The authors present a case of neonatal neuroblastoma diagnosed in prenatal age and managed with a multidisciplinary approach.
  • The echographic morphological prenatal diagnosis showed an abdominal mass of 3x2 cm located on the upper side of the kidney, which was not apparently involved.
  • Postnatal ultrasound evaluations confirmed that diagnosis.
  • These exams confirmed the presence of a mass, probably due to a neuroblastoma.
  • The histological examination confirmed the diagnosis of neuroblastoma Stage I without medullary involvement.
  • In conclusion, the effectiveness of a multidisciplinary approach of neonatal neuroblastoma is higher in the early diagnosis and in an accurate staging of the disease, which is fundamental for the favourable prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis. Prenatal Diagnosis
  • [MeSH-minor] 3-Iodobenzylguanidine. Diagnosis, Differential. Humans. Infant, Newborn. Magnetic Resonance Spectroscopy. Neoplasm Staging. Radioisotope Renography / methods. Radiopharmaceuticals. Treatment Outcome. Ultrasonography, Prenatal


59. Dubois SG, London WB, Zhang Y, Matthay KK, Monclair T, Ambros PF, Cohn SL, Pearson A, Diller L: Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer; 2008 Nov;51(5):589-92
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  • [Title] Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project.
  • BACKGROUND: Neuroblastoma is the most common extracranial pediatric solid cancer.
  • Lung metastasis is rarely detected in children with newly diagnosed neuroblastoma.
  • We aimed to describe the incidence, clinical characteristics, and outcome of patients with lung metastasis at initial diagnosis using a large international database.
  • PROCEDURE: The subset of patients from the International Neuroblastoma Risk Group database with INSS stage 4 neuroblastoma and known data regarding lung metastasis at diagnosis was selected for analysis.
  • Cox proportional hazards methods were used to determine the independent prognostic value of lung metastasis at diagnosis.
  • RESULTS: Of the 2,808 patients with INSS stage 4 neuroblastoma diagnosed between 1990 and 2002, 100 patients (3.6%) were reported to have lung metastasis at diagnosis.
  • Lung metastasis was more common among patients with MYCN amplified tumors, adrenal primary tumors, or elevated lactate dehydrogenase (LDH) levels (P < 0.02 in each case).
  • CONCLUSIONS: Lung metastasis at initial diagnosis of neuroblastoma is associated with MYCN amplification and elevated LDH levels.
  • Although lung metastasis at diagnosis was not independently predictive of outcome in this analysis, it remains a useful prognostic marker of unfavorable outcome.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18649370.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA098543; None / None / / U10 CA098543-07; United States / NCI NIH HHS / CA / U10 CA098543-07
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; EC 1.1.1.27 / L-Lactate Dehydrogenase
  • [Other-IDs] NLM/ NIHMS123413; NLM/ PMC2746936
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60. Wang X, Liang L, Jiang Y: Nine cases of childhood adrenal tumour presenting with hypertension and a review of the literature. Acta Paediatr; 2007 Jun;96(6):930-4
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  • [Title] Nine cases of childhood adrenal tumour presenting with hypertension and a review of the literature.
  • AIM: To describe the clinical features, treatment and outcome of children adrenal tumors presenting with hypertension.
  • METHODS: The records of nine children under 16 years of age with adrenal tumours presenting with hypertension were analysed.
  • RESULTS: Abdominal mass was palpable only in one patient at diagnosis.
  • Abdominal computed topography showed adrenal mass in all patients.
  • Pheochromocytoma (n = 2), adrenocortical adenoma (n = 3), adrenocortical carcinoma (n = 1), neuroblastoma (n = 2) and ganglioneuromas (n = 1) were found.
  • In one case, adrenal pheochromocytoma first occurred and non-functioning islet cell tumour successively occurred at pancreas.
  • CONCLUSIONS: Childhood adrenal tumours presented with hypertension showed an atypical course, variable presentation.
  • We report a unique case of adrenal pheochromocytoma followed by the occurrence of non-functioning islet cell tumour.
  • Imaging techniques are important to detect adrenal tumours.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Hypertension / etiology. Pheochromocytoma / complications
  • [MeSH-minor] Adolescent. Adrenocorticotropic Hormone / blood. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Longitudinal Studies. Male. Retrospective Studies. Treatment Outcome. Vanilmandelic Acid / blood


61. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • [Title] Radiological localizing techniques in adrenal tumors.
  • The characterisation of adrenal lesions is a common radiological dilemma.
  • Incidental adrenal lesions are commonly detected with computed tomography (CT), and lesion characterisation is critical.
  • The prevalence of incidental adrenal lesions has been reported to be 2.3% at autopsy and 0.5-2% with abdominal CT.
  • Although the majority of adrenal lesions are benign, in patients with an extra-adrenal primary cancer the probability of an adrenal mass being a metastasis is 52%.
  • Unfortunately, there may be significant overlap between the imaging appearances of benign lesions such as lipid-poor adenomas and malignant lesions, particularly metastases and small adrenal carcinomas.
  • This review highlights recent advances in radiological imaging of adrenal lesions and we discuss the relative merits of CT and magnetic resonance imaging to aid the identification of benign and malignant adrenal lesions and their roles, in combination with biochemical and clinical data, in recognizing common pathologies such as adrenal adenoma, phaeochromocytoma, carcinoma and metastases.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Incidental Findings. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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62. Vandesompele J, Michels E, De Preter K, Menten B, Schramm A, Eggert A, Ambros PF, Combaret V, Francotte N, Antonacci F, De Paepe A, Laureys G, Speleman F, Van Roy N: Identification of 2 putative critical segments of 17q gain in neuroblastoma through integrative genomics. Int J Cancer; 2008 Mar 1;122(5):1177-82
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  • [Title] Identification of 2 putative critical segments of 17q gain in neuroblastoma through integrative genomics.
  • Partial gain of chromosome arm 17q is the most frequent genetic change in neuroblastoma (NB) and constitutes the strongest independent genetic factor for adverse prognosis.
  • Interestingly, comparison of gene expression profiles between primary tumors and normal fetal adrenal neuroblasts revealed 2 gene clusters on chromosome 17q that are overexpressed in NB, i.e. a region on 17q21.32 immediately distal to the most distal breakpoint (in cases with single regions of gain) and 17q24.1, a region coinciding with breakpoints leading to superimposed gain.
  • [MeSH-major] Chromosomes, Human, Pair 17 / genetics. Genomics. Neuroblastoma / genetics


63. Armstrong R, Greenhalgh KL, Rattenberry E, Judd B, Shukla R, Losty PD, Maher ER: Succinate dehydrogenase subunit B (SDHB) gene deletion associated with a composite paraganglioma/neuroblastoma. J Med Genet; 2009 Mar;46(3):215-6
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  • [Title] Succinate dehydrogenase subunit B (SDHB) gene deletion associated with a composite paraganglioma/neuroblastoma.
  • [MeSH-major] Neuroblastoma / genetics. Paraganglioma, Extra-Adrenal / genetics. Succinate Dehydrogenase / genetics

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  • [CommentOn] J Med Genet. 2008 Apr;45(4):233-8 [18057081.001]
  • (PMID = 19251979.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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64. Burke MJ, Cohn SL: Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma. Pediatr Blood Cancer; 2008 Mar;50(3):679-80
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  • [Title] Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma.
  • Opsoclonus-myoclonus syndrome (OMS) is a rare paraneoplastic syndrome that occurs in 2%-3% of patients with neuroblastoma.
  • We report our experience with Rituximab in a patient with neuroblastoma and OMS.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Antibodies, Monoclonal / therapeutic use. Ganglioneuroblastoma / complications. Immunotherapy. Opsoclonus-Myoclonus Syndrome / etiology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Child Behavior Disorders / etiology. Child, Preschool. Combined Modality Therapy. Diagnostic Errors. Humans. Immunoglobulins, Intravenous / therapeutic use. Immunosuppressive Agents / therapeutic use. Learning Disorders / etiology. Male. Psychomotor Disorders / etiology. Recurrence. Rituximab

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 16900484.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunoglobulins, Intravenous; 0 / Immunosuppressive Agents; 4F4X42SYQ6 / Rituximab
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65. Sorrentino S, Conte M, Nozza P, Granata C, Capra V, Avanzini S, Garaventa A: Simultaneous occurrence of pancreatoblastoma and neuroblastoma in a newborn with beckwith-wiedemann syndrome. J Pediatr Hematol Oncol; 2010 Jul;32(5):e207-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous occurrence of pancreatoblastoma and neuroblastoma in a newborn with beckwith-wiedemann syndrome.
  • We report the case of a newborn with Beckwith-Wiedemann syndrome presenting the simultaneous occurrence of a cystic pancreatoblastoma and an adrenal neuroblastoma.
  • Surgery was required to treat the pancreatoblastoma, and a "wait and see" policy was adopted for the neuroblastoma, which spontaneously regressed within a few months.
  • [MeSH-major] Beckwith-Wiedemann Syndrome / etiology. Neoplasms, Multiple Primary / etiology. Neuroblastoma / etiology. Pancreatic Cyst / etiology. Pancreatic Neoplasms / etiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Infant, Newborn. Male. Pregnancy. Prognosis. Tomography, X-Ray Computed. Ultrasonography, Prenatal


66. De Preter K, Vandesompele J, Heimann P, Yigit N, Beckman S, Schramm A, Eggert A, Stallings RL, Benoit Y, Renard M, De Paepe A, Laureys G, Påhlman S, Speleman F: Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes. Genome Biol; 2006;7(9):R84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes.
  • BACKGROUND: Neuroblastoma tumor cells are assumed to originate from primitive neuroblasts giving rise to the sympathetic nervous system.
  • Because these precursor cells are not detectable in postnatal life, their transcription profile has remained inaccessible for comparative data mining strategies in neuroblastoma.
  • To this purpose, small islets of normal neuroblasts were isolated by laser microdissection from human fetal adrenal glands.
  • The similarities in expression profile between normal neuroblasts and malignant neuroblastomas provided strong evidence for the neuroblast origin hypothesis of neuroblastoma.
  • Next, supervised feature selection was used to identify the genes that are differentially expressed in normal neuroblasts versus neuroblastoma tumors.
  • This approach efficiently sifted out genes previously reported in neuroblastoma expression profiling studies; most importantly, it also highlighted a series of genes and pathways previously not mentioned in neuroblastoma biology but that were assumed to be involved in neuroblastoma pathogenesis.
  • CONCLUSION: This unique dataset adds power to ongoing and future gene expression studies in neuroblastoma and will facilitate the identification of molecular targets for novel therapies.
  • [MeSH-major] Gene Expression Regulation, Developmental. Gene Expression Regulation, Neoplastic. Nervous System. Neuroblastoma / genetics. Transcription, Genetic

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  • (PMID = 16989664.001).
  • [ISSN] 1474-760X
  • [Journal-full-title] Genome biology
  • [ISO-abbreviation] Genome Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC1794547
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67. Moon SB, Shin HB, Seo JM, Lee SK: Clinical features and surgical outcome of a suprarenal mass detected before birth. Pediatr Surg Int; 2010 Mar;26(3):241-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most of these masses prove to be congenital neuroblastomas (CNB), but the diagnosis is often confused with other benign lesions and the postnatal management remains to be controversial.
  • RESULTS: There were 13 cases of CNB, 1 adrenal cyst, 2 adrenal hemorrhages, and 2 pulmonary sequestrations.
  • The differential diagnosis was impossible before surgery.
  • CONCLUSION: For early diagnosis and treatment, surgical excision should be considered as the primary therapy for an antenatally detected suprarenal mass.
  • [MeSH-major] Adrenal Gland Neoplasms / congenital. Adrenal Gland Neoplasms / surgery. Neuroblastoma / congenital. Neuroblastoma / surgery. Ultrasonography, Prenatal
  • [MeSH-minor] Adrenal Gland Diseases / congenital. Adrenal Gland Diseases / diagnostic imaging. Adrenal Gland Diseases / surgery. Bronchopulmonary Sequestration / diagnostic imaging. Bronchopulmonary Sequestration / surgery. Diagnosis, Differential. Female. Gestational Age. Hemorrhage / congenital. Hemorrhage / diagnostic imaging. Hemorrhage / surgery. Humans. Infant. Infant, Newborn. Male. Neoplasm Staging. Pregnancy. Treatment Outcome

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  • (PMID = 19908050.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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68. Fox NS, Streltzoff J, Chasen ST: Spontaneous resolution of an adrenal mass seen on ultrasound at 17 weeks gestation. J Pediatr Hematol Oncol; 2008 May;30(5):405-6
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  • [Title] Spontaneous resolution of an adrenal mass seen on ultrasound at 17 weeks gestation.
  • We report a congenital neuroblastoma with findings at 17 weeks gestation that was managed expectantly; this represents the earliest reported finding of a congenital neuroblastoma we could find in the English literature.
  • [MeSH-major] Adrenal Gland Neoplasms / embryology. Neoplasm Regression, Spontaneous. Neuroblastoma / embryology. Pregnancy Trimester, Second

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  • (PMID = 18458580.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Kumar M, Gupta P, Chaubey A: The thyroid: an extremely rare primary site of neuroblastoma. Hum Pathol; 2006 Oct;37(10):1357-60
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  • [Title] The thyroid: an extremely rare primary site of neuroblastoma.
  • Neuroblastoma (NB) is uncommon in the adolescent age group.
  • It is located at any site containing sympathetic neural tissue, with retroperitoneal and adrenal lesions being the most common.
  • The differential diagnosis was primitive neuroectodermal tumor.
  • [MeSH-major] Neuroblastoma / secondary. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Neuroectodermal Tumors, Primitive / diagnosis. Phosphopyruvate Hydratase / analysis. Vanilmandelic Acid / urine

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  • (PMID = 16949905.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 55-10-7 / Vanilmandelic Acid; EC 4.2.1.11 / Phosphopyruvate Hydratase
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70. Cecchetto G, Riccipetitoni G, Inserra A, Esposito C, Michelazzi A, Ruggeri G, Spinelli C, Lima M, Italian Group of Pediatric Surgical Oncology: Minimally-invasive surgery in paediatric oncology: proposal of recommendations. Pediatr Med Chir; 2010 Sep-Oct;32(5):197-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adrenal Cortex Neoplasms / surgery. Liver Neoplasms / surgery. Lung Neoplasms / surgery. Lymphoma / surgery. Minimally Invasive Surgical Procedures. Neuroblastoma / surgery. Ovarian Neoplasms / surgery. Sarcoma / surgery. Thyroid Neoplasms / surgery
  • [MeSH-minor] Biopsy. Child. Female. Humans. Italy. Male. Neoplasm Staging


71. Kunieda E, Hirobe S, Kaneko T, Nagaoka T, Kamagata S, Nishimura G: Patterns of local recurrence after intraoperative radiotherapy for advanced neuroblastoma. Jpn J Clin Oncol; 2008 Aug;38(8):562-6
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  • [Title] Patterns of local recurrence after intraoperative radiotherapy for advanced neuroblastoma.
  • OBJECTIVE: The purpose of this study was to retrospectively evaluate local recurrence patterns after intraoperative radiation therapy (IORT) combined with total or subtotal resection and intensive chemotherapy for advanced neuroblastoma.
  • METHODS: The outcomes of 27 patients (14 boys and 13 girls) with advanced-stage neuroblastoma who received IORT as part of multimodality therapy between November 1988 and December 2006 were reviewed in order to evaluate the impact of IORT.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adrenal Gland Neoplasms / radiotherapy. Neoplasm Recurrence, Local / diagnosis. Neuroblastoma / radiotherapy. Retroperitoneal Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Infant. Intraoperative Period. Magnetic Resonance Imaging. Male. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome


72. Janjanin N, Dumic M, Skrabic V, Kusec V, Grubic Z, Spehar Uroic A: Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family. Horm Res; 2007;67(3):111-6
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  • [Title] Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family.
  • CASE REPORT: We present 5 patients with congenital adrenal hyperplasia (CAH) due to 21-OHD belonging to the 3 generations of the same family (grandmother, parents and their 2 children).
  • The probands' mother, besides the nonclassical 21-OHD, also had neuroblastoma of the adrenal gland.
  • The occurrence of neuroblastoma with 21-OHD may support the hypothesis that an impairment in the synthesis and secretion of glucocorticoids may play role in the development and functioning of the adrenal medulla.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Hyperplasia, Congenital / diagnosis. Neuroblastoma / complications. Steroid 21-Hydroxylase


73. Hill G, Castellino S, Williams D: Cardiac myxoma after treatment for childhood neuroblastoma. Pediatr Cardiol; 2009 Apr;30(3):340-2
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  • [Title] Cardiac myxoma after treatment for childhood neuroblastoma.
  • An asymptomatic 13 year old with a history of neuroblastoma treated with chemotherapy, radiation therapy, and autologous bone marrow transplant was found to have a cardiac mass on screening echocardiogram.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Heart Neoplasms / etiology. Myxoma / etiology. Neuroblastoma / therapy
  • [MeSH-minor] Adolescent. Cardiac Surgical Procedures. Diagnosis, Differential. Echocardiography. Follow-Up Studies. Humans. Male. Risk Factors. Tomography, X-Ray Computed


74. Tajiri S: [Vanillylmandelic acid (VMA) and homovanillic acid (HVA)]. Nihon Rinsho; 2005 Aug;63 Suppl 8:399-403
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  • [MeSH-minor] Adrenal Gland Neoplasms / diagnosis. Biomarkers / analysis. Chromatography, High Pressure Liquid. Chronic Disease. Depressive Disorder / diagnosis. Hepatitis / diagnosis. Humans. Melanoma / diagnosis. Multiple System Atrophy / diagnosis. Neuroblastoma / diagnosis. Pheochromocytoma / diagnosis. Reference Values. Specimen Handling

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  • (PMID = 16149539.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 55-10-7 / Vanilmandelic Acid; X77S6GMS36 / Homovanillic Acid
  • [Number-of-references] 9
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75. Schiavetti A, Foco M, Ingrosso A, Chiriacò D, Ballesio L: Congenital stage 1 neuroblastoma evolved into stage 4s. J Pediatr Hematol Oncol; 2009 Jan;31(1):59-60
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  • [Title] Congenital stage 1 neuroblastoma evolved into stage 4s.
  • A newborn with a prenatally detected adrenal mass underwent complete resection of a stage 1 favorable histology neuroblastoma (NB) without MYC-N amplification.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasm Regression, Spontaneous. Neuroblastoma / pathology. Ultrasonography, Prenatal
  • [MeSH-minor] Female. Genes, myc. Humans. Infant, Newborn. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Male. Neoplasm Staging. Neoplasm, Residual / prevention & control. Pregnancy


76. Bozzi F, Gambirasio F, Luksch R, Collini P, Brando B, Fossati-Bellani F: Detecting CD56+/NB84+/CD45- immunophenotype in the bone marrow of patients with metastatic neuroblastoma using flow cytometry. Anticancer Res; 2006 Sep-Oct;26(5A):3281-7
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  • [Title] Detecting CD56+/NB84+/CD45- immunophenotype in the bone marrow of patients with metastatic neuroblastoma using flow cytometry.
  • BACKGROUND: In order to identify neuroblastoma cells infiltrating the bone marrow, a triple-color flow-cytometric assay was developed combining CD56 and CD45 with the intracellular anti-NB84 specific antibody.
  • MATERIALS AND METHODS: The bilateral aspirates obtained from 27 consecutive children over the age of one year with stage 4 neuroblastoma were evaluated.
  • RESULTS: Neuroblastoma cells were detected in the bone marrow of 17/27 (63%) and 19/27 (70%) cases using cytomorphology and triple-color flow-cytometry, respectively.
  • CONCLUSION: By combining CD45 and CD56 with the specific antibody, NB84, directed against neuroblastoma cells, we developed a rapid and reliable cytometric assay that can be associated with conventional cytomorphological bone marrow evaluation to detect infiltrating neuroblastoma cells, especially in cases of dubious positivity.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Antigens, CD45 / metabolism. Antigens, CD56 / metabolism. Antigens, Neoplasm / metabolism. Bone Marrow Cells / pathology. Bone Marrow Neoplasms / pathology. Neuroblastoma / diagnosis
  • [MeSH-minor] Adrenal Gland Neoplasms / metabolism. Adrenal Gland Neoplasms / pathology. Biomarkers, Tumor / analysis. Female. Flow Cytometry. Humans. Immunophenotyping. Male. Mediastinal Neoplasms / metabolism. Mediastinal Neoplasms / pathology. Retroperitoneal Neoplasms / metabolism. Retroperitoneal Neoplasms / pathology. Survival Rate

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  • (PMID = 17094441.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD56; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; EC 3.1.3.48 / Antigens, CD45
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77. Roma J, Saus E, Cuadros M, Reventós J, Sánchez de Toledo J, Gallego S: Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours. Biol Chem; 2007 Apr;388(4):419-26
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  • The mRNA distribution of these novel hTH isoforms in neuroblastic tumours and in foetal adrenal glands was analysed by conventional and real-time RT-PCR.
  • Their general distribution in neuroblastoma and adrenal glands and translation into protein suggest a significant functional role for these novel hTH isoforms, which merit further study.
  • [MeSH-major] Alternative Splicing / genetics. Neuroblastoma / enzymology. Tyrosine 3-Monooxygenase / genetics

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  • (PMID = 17391063.001).
  • [ISSN] 1431-6730
  • [Journal-full-title] Biological chemistry
  • [ISO-abbreviation] Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Recombinant Proteins; EC 1.14.16.2 / Tyrosine 3-Monooxygenase
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78. Duzovali O, Ozer C, Turhan AH, Arslankoylu AE, Yilgor E, Polat A, Aksoyek S: Bilateral adrenal cystic neuroblastoma with massive hepatomegaly and intracystic hemorrhage. Pediatr Blood Cancer; 2005 May;44(5):525-6
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  • [Title] Bilateral adrenal cystic neuroblastoma with massive hepatomegaly and intracystic hemorrhage.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Hemorrhage / diagnosis. Hemorrhage / etiology. Hepatomegaly / etiology. Humans. Infant, Newborn


79. McHugh K: Renal and adrenal tumours in children. Cancer Imaging; 2007;7:41-51
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  • [Title] Renal and adrenal tumours in children.
  • The differential diagnosis of renal and supra-renal masses firstly depends on the age of the child.
  • Neuroblastoma (NBL) may be seen antenatally or in the newborn period; this tumour has a good prognosis unlike NBL seen in older children (particularly NBL in those aged 2-4 years).
  • Adrenal adenomas and carcinomas also occur in childhood; these tumours are indistinguishable on imaging but criteria for the diagnosis of adrenal carcinoma include size larger than 5 cm, a tendency to invade the inferior vena cava and to metastasise.
  • The most topical dilemmas in the radiological assessment of renal and adrenal tumours are presented.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Diagnostic Imaging / methods. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Age of Onset. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / epidemiology. Child. Child, Preschool. Diagnosis, Differential. Ganglioneuroblastoma / diagnosis. Ganglioneuroblastoma / epidemiology. Ganglioneuroblastoma / pathology. Humans. Infant. Infant, Newborn. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Mass Screening. Neoplasm Staging. Neuroblastoma / diagnosis. Neuroblastoma / epidemiology. Neuroblastoma / pathology. Neuroblastoma / secondary. Neuroblastoma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / epidemiology. Positron-Emission Tomography. Tomography, X-Ray Computed. Wilms Tumor / diagnosis. Wilms Tumor / epidemiology. Wilms Tumor / pathology. Wilms Tumor / therapy

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  • (PMID = 17339140.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 19
  • [Other-IDs] NLM/ PMC1828369
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80. Cozzi DA, Spagnol L: Fetal adrenal cysts with hemorrhagic appearance may be cystic neuroblastomas. Fetal Diagn Ther; 2009;25(3):359; author reply 360
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  • [Title] Fetal adrenal cysts with hemorrhagic appearance may be cystic neuroblastomas.
  • [MeSH-major] Adrenal Gland Diseases / ultrasonography. Cysts / ultrasonography. Hemorrhage / ultrasonography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neuroblastoma / diagnosis. Pregnancy

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  • [CommentOn] Fetal Diagn Ther. 2008;23(1):72-5 [17934302.001]
  • (PMID = 19776603.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Switzerland
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81. Ramljak V, Ranogajec I, Novosel I, Knezević F, Velemir-Vrdoljak D, Janusić R, Dosen D: Thyroid tumour in a child previously treated for neuroblastoma. Cytopathology; 2006 Oct;17(5):295-8
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  • [Title] Thyroid tumour in a child previously treated for neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiotherapy. Carcinoma, Papillary / pathology. Neoplasms, Second Primary / pathology. Neuroblastoma / radiotherapy. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Child. Combined Modality Therapy. Female. Humans. Neoplasms, Radiation-Induced. Radiotherapy / adverse effects. Thyroid Gland / radiation effects


82. Martin DT, Gendron RL, Jarzembowski JA, Perry A, Collins MH, Pushpanathan C, Miskiewicz E, Castle VP, Paradis H: Tubedown expression correlates with the differentiation status and aggressiveness of neuroblastic tumors. Clin Cancer Res; 2007 Mar 1;13(5):1480-7
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  • PURPOSE: The discovery and validation of new prognostic factors and further refinement of risk group stratification are needed to improve clinical interpretation of neuroblastoma.
  • EXPERIMENTAL DESIGN: Tubedown protein expression was quantitatively assessed in neuroblastic tumors (neuroblastomas, ganglioneuroblastomas, and ganglioneuromas) and normal adrenal tissues using Western blot and OE5 immunohistochemistry.
  • Regulation of Tubedown expression during retinoic acid-induced neuronal differentiation in neuroblastoma cell lines was assessed by Western blotting.
  • In vitro, marked retinoic acid-induced neuronal differentiation responses of neuroblastoma cells are associated with a significant decrease in Tubedown expression, whereas limited neuronal differentiation responses to retinoic acid were associated with little or no decrease in Tubedown expression.
  • CONCLUSIONS: Our results indicate that the levels of Tubedown expression are linked to the differentiation status and aggressiveness of neuroblastic tumors and represent an independent prognostic factor for neuroblastoma.
  • Tubedown expression may be useful to more accurately define different neuroblastic tumor subsets and ultimately provide more adequate assessment and treatment for neuroblastoma patients.
  • [MeSH-major] Acetyltransferases / biosynthesis. Biomarkers, Tumor / analysis. Brain Neoplasms / metabolism. Neuroblastoma / metabolism

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  • (PMID = 17332292.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA69276-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.3.1.- / Acetyltransferases
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83. Kinlaw WB, Scott SM, Maue RA, Memoli VA, Harris RD, Daniels GH, Porter DM, Belloni DR, Spooner ET, Ernesti MM, Noll WW: Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma. Clin Endocrinol (Oxf); 2005 Dec;63(6):676-82
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  • Of the 15 mutation-positive family members, 11 agreed to undergo further evaluation by physical examination, calcium and pentagastrin-stimulated calcitonin levels, measurement of urinary metanephrines, adrenal imaging and serum calcium levels.
  • Biochemical characterization of the mutation was by transient transfection of human neuroblastoma cells and Western blot analysis.
  • Transfection experiments using human neuroblastoma cells showed that the mutant RET, unlike the wild-type receptor, is constitutively phosphorylated in the absence of ligand, and thus resembles other previously characterized MEN 2A mutations.
  • [MeSH-major] Carcinoma, Medullary / genetics. Multiple Endocrine Neoplasia Type 2a / diagnosis. Pheochromocytoma / genetics. Point Mutation. Proto-Oncogene Proteins c-ret / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Calcitonin / blood. Calcium. Catecholamines / urine. Child. Codon. Female. Humans. Male. Metanephrine / urine. Middle Aged. Pedigree. Pentagastrin. Polymorphism, Restriction Fragment Length. Sequence Analysis, DNA. Thyroid Gland / pathology. Vanilmandelic Acid / urine


84. Normand C, Leblond P, Mazingue F, Nelken B, Defachelles AS, Bonnevalle M: A case of adrenal haemorrhage after minor trauma in a young child: think of neuroblastoma. Eur J Pediatr Surg; 2006 Oct;16(5):365-8
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  • [Title] A case of adrenal haemorrhage after minor trauma in a young child: think of neuroblastoma.
  • We report a case of neuroblastoma diagnosed after adrenal haemorrhage following a minor trauma in a thirteen-month-old boy.
  • Therefore when no accepted cause for AH can be found in a young child below the age of 5 years, it is important to look for a neuroblastoma and discuss the necessity of surgical exploration.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemorrhage / etiology. Neuroblastoma / diagnosis
  • [MeSH-minor] Accidental Falls. Adrenal Glands / blood supply. Fatal Outcome. Humans. Infant. Male. Tomography, X-Ray Computed

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  • (PMID = 17160786.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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85. Adaletli I, Kurugoglu S, Aki H, Mihmanli I: Simultaneous presentation of congenital neuroblastoma in monozygotic twins: a case of possible twin-to-twin metastasis. AJR Am J Roentgenol; 2006 Apr;186(4):1172-5
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  • [Title] Simultaneous presentation of congenital neuroblastoma in monozygotic twins: a case of possible twin-to-twin metastasis.
  • [MeSH-major] Adrenal Gland Neoplasms / congenital. Adrenal Gland Neoplasms / secondary. Diseases in Twins / congenital. Liver Neoplasms / congenital. Liver Neoplasms / secondary. Neuroblastoma / congenital. Neuroblastoma / secondary. Twins, Monozygotic


86. Samms WC, Perera RP, Wimalasena DS, Wimalasena K: Perturbation of dopamine metabolism by 3-amino-2-(4'-halophenyl)propenes leads to increased oxidative stress and apoptotic SH-SY5Y cell death. Mol Pharmacol; 2007 Sep;72(3):744-52
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  • We have recently characterized a series of 3-amino-2-phenyl-propene (APP) derivatives as reversible inhibitors for the bovine adrenal chromaffin granule vesicular monoamine transporter (VMAT) that have been previously characterized as potent irreversible dopamine-beta-monooxygenase (DbetaM) and monoamine oxidase (MAO) inhibitors.
  • More importantly, these derivatives are highly toxic to human neuroblastoma SH-SY5Y but not toxic to M-1, Hep G2, or human embryonic kidney 293 non-neuronal cells at similar concentrations.
  • [MeSH-minor] Animals. Cell Death / drug effects. Cell Line, Tumor. Cell Survival / drug effects. Dose-Response Relationship, Drug. Hydrocarbons, Halogenated / chemistry. Hydrocarbons, Halogenated / pharmacology. Mice. Neuroblastoma / pathology. Time Factors

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  • (PMID = 17576792.001).
  • [ISSN] 0026-895X
  • [Journal-full-title] Molecular pharmacology
  • [ISO-abbreviation] Mol. Pharmacol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS39423
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allyl Compounds; 0 / Benzene Derivatives; 0 / Hydrocarbons, Halogenated; T75W9911L6 / Propane; VTD58H1Z2X / Dopamine
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87. Mena Bares LM, Benítez Velazco A, Pérez Cuenca E, Maza Muret FR, Hidalgo Ramos FJ, Pacheco Capote C, Contreras Puertas PI, Latre Romero JM: [Utility of the scintigraphy with (123)I MIBG in the diagnosis of neuroblastoma bone metastasis]. Rev Esp Med Nucl; 2009 Jul-Aug;28(4):208-9
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  • [Title] [Utility of the scintigraphy with (123)I MIBG in the diagnosis of neuroblastoma bone metastasis].
  • [Transliterated title] Utilidad de la gammagrafía con (123)I MIBG en el diagnóstico de metástasis óseas de neuroblastoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Bone Marrow Neoplasms / radionuclide imaging. Bone Marrow Neoplasms / secondary. Iodine Radioisotopes. Neuroblastoma / radionuclide imaging. Neuroblastoma / secondary. Radiopharmaceuticals
  • [MeSH-minor] Adrenal Gland Neoplasms / radionuclide imaging. Child, Preschool. Humans. Ilium / radionuclide imaging. Male. Technetium Tc 99m Medronate / analogs & derivatives. Tibia / radionuclide imaging

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  • (PMID = 19922836.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine; 72945-61-0 / technetium Tc 99m hydroxymethylene diphosphonate; X89XV46R07 / Technetium Tc 99m Medronate
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88. Tsuchida Y, Miyauchi J, Kuroiwa M, Suzuki N, Sakamoto J, Suzuki M, Shitara T: Histologic survey of neuroblastomas after intensive induction chemotherapy. Pediatr Blood Cancer; 2005 Oct 15;45(5):656-62
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  • BACKGROUND: Histology after intensive induction chemotherapy is expected to become a beacon indicating when and how extensively radical surgery and lymph node dissection should be performed in advanced neuroblastoma.
  • [MeSH-major] Abdominal Neoplasms / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neuroblastoma / pathology
  • [MeSH-minor] Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / pathology. Child. Child, Preschool. Humans. Infant. Lymphatic Metastasis

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  • (PMID = 15929130.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Longo L, Borghini S, Schena F, Parodi S, Albino D, Bachetti T, Da Prato L, Truini M, Gambini C, Tonini GP, Ceccherini I, Perri P: PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. Int J Oncol; 2008 Nov;33(5):985-91
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  • [Title] PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma.
  • The detection of PHOX2B mutations in a small proportion of patients affected with either familial or sporadic neuroblastoma (NB), has arisen interest on the possible pathogenic role of this gene in the disease determination.
  • In this light, we have carried out a quantitative expression analysis of PHOX2B and its paralogue PHOX2A on a panel of NB cell lines and NB tumour samples to identify a possible differential expression between NB cells and their normal counterpart (adrenal medulla cells).
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Homeodomain Proteins / genetics. Neuroblastoma / genetics. Transcription Factors / genetics
  • [MeSH-minor] Adrenal Medulla / metabolism. Cell Line, Tumor. DNA Mutational Analysis. Humans. Pedigree. Up-Regulation

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  • (PMID = 18949361.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / NBPhox protein; 0 / PHOX2A protein, human; 0 / Transcription Factors
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90. Rumińska M, Welc-Dobies J, Lange M, Maciejewska J, Pyrzak B, Brzewski M: [Adrenal haemorrhage in neonates: risk factors and diagnostic and clinical procedure]. Med Wieku Rozwoj; 2008 Jan-Mar;12(1):457-62
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  • [Title] [Adrenal haemorrhage in neonates: risk factors and diagnostic and clinical procedure].
  • Prenatal and neonatal adrenal haemorrhage is being increasingly frequently reported.
  • We present a group of 13 neonates with adrenal haemorrhage, hospitalised in the Department of Paediatrics and Endocrinology of Warsaw Medical University from 2003 to 2007.
  • THE AIM: of this study was to analyse: the perinatal history, haemorrhage predisposing factors, its size, localization and progress estimated by ultrasonography, as well as clinical, biochemical and hormonal findings indicating adrenal insufficiency.
  • MATERIAL AND METHODS: the study group comprised 13 neonates hospitalised in the Department of Paediatrics and Endocrinology, Warsaw Medical University, from 2003 to 2007, due to adrenal haemorrhage diagnosed by ultrasonography in the first week of life.
  • One neonate had bilateral adrenal haemorrhage, others were unilateral - predominantly right-sided.
  • Only one patient with bilateral adrenal haemorrhage showed sings of adrenal insufficiency and supplementation with glyco- and mineralcorticoids was necessary.
  • Complete resolution of adrenal haemorrhage was reported after an average time of 3.5 months of observation.
  • Adrenal haemorrhage in neonates rarely leads to development of adrenal insufficiency.
  • 2. In neonates with bilateral adrenal haemorrhage an extended hormonal diagnosis is required.
  • Unilateral haemorrhage should be differentiated from neuroblastoma.
  • 4. Scrotal haematoma may be a symptom of adrenal haemorrhage.
  • [MeSH-major] Adrenal Gland Diseases / ultrasonography. Hemorrhage / ultrasonography. Infant, Newborn, Diseases / ultrasonography
  • [MeSH-minor] Adrenal Glands / blood supply. Female. Humans. Infant, Newborn. Male. Retrospective Studies. Risk Factors


91. Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Nakao K, Maitani Y: Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma. Int J Oncol; 2010 Sep;37(3):695-705
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  • [Title] Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma.
  • Adrenal neuroblastoma and pheochromocytoma have the same embryonic origin from neural crest cells and mainly arise from the adrenal medulla.
  • Recently, transgenic mice exhibiting tumors in the bilateral adrenal medulla by the expression of SV40 T-antigen were developed.
  • In this study, we investigated mRNA expression in adrenal tumors of transgenic mice and compared them with human pheochromocytoma by DNA microarray analysis.
  • To compare mouse adrenal tumors and human pheochromacytoma, we found that the expressions of noradrenergic neuron-related genes, including dopa decarboxylase, phenylethanolamine-N-methyltransferase and chromogranin B, were up-regulated in humans but not in mice; however, the expression of neuroblastoma-related genes, including Mycn, paired-like homeobox 2b, gamma-aminobutyric acid A receptor beta3 subunit, islet 1 and kinesin family member 1A, was up-regulated in both species.
  • From the gene expression profiles, the characterization of mouse adrenal tumor, may be similar to that of human adrenal neuroblastoma rather than pheochromacytomas.
  • This mouse model would be a useful tool for the development of anti-cancer drugs and for understanding the etiology of adrenal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics


92. Balaji R, Ramachandran K, Kusumakumari P: Neuroimaging patterns of central nervous system metastases in neuroblastoma: report of 2 recent cases and literature review. J Child Neurol; 2009 Oct;24(10):1290-3
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  • [Title] Neuroimaging patterns of central nervous system metastases in neuroblastoma: report of 2 recent cases and literature review.
  • The authors describe imaging patterns of intracranial metastases in 2 children with grade 4 neuroblastoma.
  • Central nervous system metastases from neuroblastoma are extremely rare and may involve the cerebral parenchyma, leptomeninges, or dura.
  • Central nervous system involvement in both patients occurred within a time span ranging from 12 to 14 months from the time of initial diagnosis.
  • [MeSH-major] Brain Neoplasms / secondary. Neuroblastoma / secondary
  • [MeSH-minor] Adrenal Gland Neoplasms / pathology. Brain / pathology. Brain / radiography. Child, Preschool. Female. Humans. Magnetic Resonance Imaging. Male. Thoracic Neoplasms / pathology. Tomography, X-Ray Computed


93. Muller A, Glattard E, Taleb O, Kemmel V, Laux A, Miehe M, Delalande F, Roussel G, Van Dorsselaer A, Metz-Boutigue MH, Aunis D, Goumon Y: Endogenous morphine in SH-SY5Y cells and the mouse cerebellum. PLoS One; 2008;3(2):e1641
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  • Recently, using the adrenal neuroendocrine chromaffin cell model, we have shown the presence of morphine-6-glucuronide (M6G) in secretory granules and their secretion products, leading us to propose that these endogenous alkaloids might represent new neuroendocrine factors.
  • METHODOLOGY AND PRINCIPAL FINDINGS: Microscopy, molecular biology, electrophysiology, and proteomic tools were applied to human neuroblastoma SH-SY5Y cells (i) to characterize morphine and M6G, and (ii) to demonstrate the presence of the UDP-glucuronyltransferase 2B7 enzyme, which is responsible for the formation of M6G from morphine.
  • [MeSH-minor] Alkaloids. Animals. Cell Line, Tumor. Electrophysiology. Humans. Mice. Neuroblastoma. Purkinje Cells. Synaptic Transmission

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  • (PMID = 18327293.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Morphine Derivatives; 20290-10-2 / morphine-6-glucuronide; 76I7G6D29C / Morphine; EC 2.4.1.17 / Glucuronosyltransferase
  • [Other-IDs] NLM/ PMC2265639
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94. Tanno B, Mancini C, Vitali R, Mancuso M, McDowell HP, Dominici C, Raschellà G: Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res; 2006 Nov 15;12(22):6772-80
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  • [Title] Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo.
  • Neuroblastoma is sensitive to IGF.
  • EXPERIMENTAL DESIGN: We assessed the ability of NVP-AEW541, a recently developed small molecule that selectively inhibits IGF-IR activity, for neuroblastoma growth effects in vitro and in vivo.
  • Our data showed that, in a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar (0.4-6.8) range of concentrations.
  • Oral administration of NVP-AEW541 (50 mg/kg twice daily) inhibited tumor growth of neuroblastoma xenografts in nude mice.
  • In addition, in Matrigel-coated chambers and in severe combined immunodeficient mice tail vein injected with neuroblastoma cells, tumor invasiveness was significantly reduced by this agent.
  • Analysis of IGF-IR expression in a series of 43 neuroblastoma primary tumors revealed IGF-IR positivity in 86% of cases.
  • CONCLUSIONS: Taken together, these data indicate that NVP-AEW541 can be considered as a novel promising candidate for treatment of neuroblastoma patients.
  • [MeSH-major] Brain Neoplasms / drug therapy. Neuroblastoma / drug therapy. Pyrimidines / pharmacology. Pyrimidines / therapeutic use. Pyrroles / pharmacology. Pyrroles / therapeutic use. Receptor, IGF Type 1 / antagonists & inhibitors
  • [MeSH-minor] Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / secondary. Animals. Antineoplastic Agents / pharmacology. Antineoplastic Agents / therapeutic use. Cell Proliferation / drug effects. Down-Regulation. Humans. Kidney Neoplasms / drug therapy. Kidney Neoplasms / secondary. Male. Mice. Mice, Nude. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / prevention & control. Phosphorylation. Proto-Oncogene Proteins c-akt / metabolism. Transplantation, Heterologous / pathology. Tumor Burden / drug effects. Tumor Cells, Cultured. Xenograft Model Antitumor Assays

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  • (PMID = 17121898.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / NVP-AEW541; 0 / Pyrimidines; 0 / Pyrroles; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
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95. Schalk E, Mohren M, Koenigsmann M, Buhtz P, Franke A, Jentsch-Ullrich K: Metastatic adrenal neuroblastoma in an adult. Onkologie; 2005 Jun;28(6-7):353-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adrenal neuroblastoma in an adult.
  • BACKGROUND: Neuroblastoma (NB) is a common malignancy in children, but rarely occurs in adults.
  • In adults, abdomen/retroperitoneum are the primary sites and in children the adrenal gland.
  • Tumour resection revealed adrenal NB grade III.
  • Chemotherapy according to the paediatric German Neuroblastoma Trial (NB97) was started.
  • The patient died 9 months after diagnosis.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neuroblastoma / pathology. Neuroblastoma / secondary


96. Pianovski MA, Maluf EM, de Carvalho DS, Ribeiro RC, Rodriguez-Galindo C, Boffetta P, Zancanella P, Figueiredo BC: Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. Pediatr Blood Cancer; 2006 Jul;47(1):56-60
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  • BACKGROUND: Several reports refer to an increased frequency of adrenal cortex tumors (ACT) among children in Southern Brazil, yet all data have been derived from hospital-based registries.
  • PROCEDURE: We reviewed all death certificates that mentioned ACT or adrenal neuroblastoma (NB) and which were reported to the Paraná State Department of Health between 1998 and 2003, for individuals younger than 15 years who resided in the Curitiba metropolitan region.
  • The ratio of the adrenal NB and ACT age-adjusted mortality rates was 1.43.
  • [MeSH-major] Adrenal Cortex Neoplasms / mortality
  • [MeSH-minor] Adolescent. Brazil / epidemiology. Child. Child, Preschool. Genes, p53 / genetics. Humans. Incidence. Infant. Infant, Newborn. Mutation. Neuroblastoma / mortality. Survival Rate

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16200634.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Köksal Y, Varan A, Kale G, Tanyel FC, Büyükpamukçu M: Bilateral adrenal cystic neuroblastoma with hepatic and splenic involvement in a newborn. J Pediatr Hematol Oncol; 2005 Dec;27(12):670-1
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  • [Title] Bilateral adrenal cystic neuroblastoma with hepatic and splenic involvement in a newborn.
  • Bilateral cystic adrenal neuroblastoma is an unusual variant of neuroblastoma, and only two cases have been reported in the neonatal period until now.
  • The authors describe a newborn with splenic and hepatic involvement of bilateral adrenal cystic neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / congenital. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / secondary. Neuroblastoma / congenital. Splenic Neoplasms / secondary


98. Sultan I, Ghandour K, Al-Jumaily U, Hashem S, Rodriguez-Galindo C: Local control of the primary tumour in metastatic neuroblastoma. Eur J Cancer; 2009 Jul;45(10):1728-32
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  • [Title] Local control of the primary tumour in metastatic neuroblastoma.
  • The previous studies have stressed on the importance of loco-regional control in the management of high-risk neuroblastoma.
  • We searched the Surveillance, Epidemiology and End-Results (SEER) database for patients older than 2years with metastatic neuroblastoma who were diagnosed from 1998 to 2005.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Neuroblastoma / secondary. Neuroblastoma / surgery

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  • (PMID = 19447607.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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99. Poliani PL, Mitola S, Ravanini M, Ferrari-Toninelli G, D'Ippolito C, Notarangelo LD, Bercich L, Wagener C, Memo M, Presta M, Facchetti F: CEACAM1/VEGF cross-talk during neuroblastic tumour differentiation. J Pathol; 2007 Apr;211(5):541-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In keeping with these observations, VEGF expression was found in human neuroblastoma SH-SY5Y cells during differentiation after retinoic acid treatment.
  • [MeSH-major] Adrenal Gland Neoplasms / physiopathology. Antigens, CD / physiology. Cell Adhesion Molecules / physiology. Mediastinal Neoplasms / physiopathology. Neovascularization, Pathologic / physiopathology. Neuroblastoma / physiopathology. Vascular Endothelial Growth Factor A / physiology
  • [MeSH-minor] Adolescent. Adrenal Glands / blood supply. Cell Differentiation / physiology. Cells, Cultured. Child. Child, Preschool. Endothelial Cells / chemistry. Female. Ganglia / chemistry. Humans. Immunohistochemistry / methods. Infant. Male. Mediastinum / blood supply. Microcirculation. Up-Regulation / physiology

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  • [Copyright] Copyright (c) 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 17310502.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD66 antigens; 0 / Cell Adhesion Molecules; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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100. Rabah R, Weber R, Serhatkulu GK, Cao A, Dai H, Pandya A, Naik R, Auner G, Poulik J, Klein M: Diagnosis of neuroblastoma and ganglioneuroma using Raman spectroscopy. J Pediatr Surg; 2008 Jan;43(1):171-6
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  • [Title] Diagnosis of neuroblastoma and ganglioneuroma using Raman spectroscopy.
  • BACKGROUND: Raman spectroscopy has proven to be useful in studying premalignant and malignant lesions in adults.
  • This is the first report to evaluate Raman spectroscopy in the diagnosis and classification of neuroblastoma in children.
  • METHODS: A biopsy or resection of fresh tissue samples from normal adrenal glands, neuroblastomas, ganglioneuromas, nerve sheath tumors, and pheochromocytoma at our hospital were equally divided between routine histology and spectroscopic studies.
  • RESULTS: We collected 698 spectra from 16 neuroblastomas, 5 ganglioneuromas, 3 normal adrenal glands, 6 nerve sheath tumors, and 1 pheochromocytoma.
  • Raman spectroscopy differentiated between normal adrenal gland, and neuroblastoma and ganglioneuroma with 100% sensitivity and 100% specificity.
  • It was also able to differentiate neuroblastoma from nerve sheath tumors and pheochromocytoma with high sensitivity and specificity.
  • CONCLUSION: This technique can differentiate neuroblastoma from ganglioneuroma and other tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Ganglioneuroma / diagnosis. Neuroblastoma / diagnosis. Pheochromocytoma / diagnosis. Spectrum Analysis, Raman / methods
  • [MeSH-minor] Biopsy, Needle. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Male. Sampling Studies. Sensitivity and Specificity. Tissue Embedding






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