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1. Refaat MM, Idriss SZ, Blaszkowsky LS: Case report: an unusual case of adrenal neuroblastoma in pregnancy. Oncologist; 2008 Feb;13(2):152-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report: an unusual case of adrenal neuroblastoma in pregnancy.
  • Neuroblastomas are the fourth most common malignancy of childhood and account for most adrenal tumors in children.
  • We present herein an extremely rare case of adrenal neuroblastoma occurring in a 25-year-old woman during her first trimester of pregnancy.
  • Adult adrenal neuroblastoma is an uncommon malignancy and, to our knowledge, there was no case of this tumor occurring in pregnancy ever described in the English literature.
  • The case presentation is followed by a general discussion with an emphasis on the diagnosis, treatment, and follow-up of neuroblastoma and its association with pregnancy.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenalectomy. Neuroblastoma / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Abortion, Spontaneous / etiology. Adult. Chorioamnionitis / etiology. Female. Humans. Neoplasm Staging. Pregnancy. Pregnancy Trimester, First. Risk Factors


2. Miwa Y, Uchida K, Nakayama H, Asaki N: Neuroblastoma of the adrenal gland in a ferret. J Vet Med Sci; 2010 Sep;72(9):1229-32
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  • [Title] Neuroblastoma of the adrenal gland in a ferret.
  • The excised mass was histologically diagnosed as a medullary tumor of the adrenal gland, and some neoplastic cells were beta III-tubulin-, doublecortin- and neurofilament-positive.
  • Based on these findings, the tumor was considered to be a neuroblastoma.

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  • (PMID = 20431253.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Jacob ES, Varghese RG, Toi PC, Bhaskaran R, Rai R: Congenital neuroblastoma with liver metastasis presenting with Hashimoto Pritzker disease. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):374-6
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  • [Title] Congenital neuroblastoma with liver metastasis presenting with Hashimoto Pritzker disease.
  • She was earlier diagnosed to have neuroblastoma of the adrenal gland which had metastasized to the liver.
  • [MeSH-major] Infant, Newborn, Diseases / diagnosis. Infant, Newborn, Diseases / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Neuroblastoma / diagnosis. Neuroblastoma / pathology
  • [MeSH-minor] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Female. Histocytochemistry. Humans. Infant. Infant, Newborn. Pregnancy. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Neoplasms / secondary. Young Adult


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4. Pagès PM, Dufour C, Fasola S, Michon J, Boutard P, Gentet JC, Hartmann O: Bilateral adrenal neuroblastoma. Pediatr Blood Cancer; 2009 Feb;52(2):196-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral adrenal neuroblastoma.
  • BACKGROUND: Bilateral adrenal neuroblastoma is extremely rare.
  • PROCEDURES: We retrospectively identified and reviewed 15 cases of bilateral adrenal neuroblastoma, treated between 1988 and 2004, by the French Society of Pediatric Oncology.
  • RESULTS: Median age at diagnosis was 4 months in our cohort whereas it was 3 months in the literature.
  • Ten out of 15 patients in our cohort and 18/39 cases in the literature were classified as stage 4S according to the International Neuroblastoma Staging System (INSS).
  • The incidence of stage 4S was significantly higher than that described in other neuroblastoma cohorts (P = 10(-4)).
  • In our series, bilateral neuroblastoma was neither associated with familial cases nor with any risk factors.
  • CONCLUSIONS: The majority of bilateral neuroblastoma carry a favorable prognosis.
  • Exceptional cases exhibiting risk factors, such as amplified MYCN, are comparable to high-risk unilateral neuroblastoma cases with the same poor prognostic features.
  • The therapeutic strategy could be similar to that used against unilateral neuroblastoma, except for surgery.
  • However, the low incidence of relapse and the risk of adrenal failure if radical surgery is performed, argue against an aggressive surgical approach.
  • [MeSH-major] Adrenal Gland Neoplasms / epidemiology. Neuroblastoma / epidemiology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18951434.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins
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5. Pederiva F, Andres A, Sastre A, Alves J, Martinez L, Tovar JA: Bilateral adrenal neuroblastoma is different. Eur J Pediatr Surg; 2007 Dec;17(6):393-6
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  • [Title] Bilateral adrenal neuroblastoma is different.
  • BACKGROUND/AIMS: Bilateral adrenal neuroblastoma is rare and can be due to multifocal primary or contralateral metastasis.
  • The present study examines the clinical, biological and therapeutic features of bilateral adrenal neuroblastoma.
  • CONCLUSIONS: Bilateral adrenal neuroblastomas fit neither into stage 4 s nor into stage 4.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Adrenalectomy / methods. Antineoplastic Agents / therapeutic use. Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Male. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 18072022.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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6. De Preter K, Vandesompele J, Heimann P, Yigit N, Beckman S, Schramm A, Eggert A, Stallings RL, Benoit Y, Renard M, De Paepe A, Laureys G, Påhlman S, Speleman F: Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes. Genome Biol; 2006;7(9):R84
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  • [Title] Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes.
  • BACKGROUND: Neuroblastoma tumor cells are assumed to originate from primitive neuroblasts giving rise to the sympathetic nervous system.
  • Because these precursor cells are not detectable in postnatal life, their transcription profile has remained inaccessible for comparative data mining strategies in neuroblastoma.
  • To this purpose, small islets of normal neuroblasts were isolated by laser microdissection from human fetal adrenal glands.
  • The similarities in expression profile between normal neuroblasts and malignant neuroblastomas provided strong evidence for the neuroblast origin hypothesis of neuroblastoma.
  • Next, supervised feature selection was used to identify the genes that are differentially expressed in normal neuroblasts versus neuroblastoma tumors.
  • This approach efficiently sifted out genes previously reported in neuroblastoma expression profiling studies; most importantly, it also highlighted a series of genes and pathways previously not mentioned in neuroblastoma biology but that were assumed to be involved in neuroblastoma pathogenesis.
  • CONCLUSION: This unique dataset adds power to ongoing and future gene expression studies in neuroblastoma and will facilitate the identification of molecular targets for novel therapies.
  • [MeSH-major] Gene Expression Regulation, Developmental. Gene Expression Regulation, Neoplastic. Nervous System. Neuroblastoma / genetics. Transcription, Genetic

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  • [ErratumIn] Genome Biol. 2007;8(1):401
  • (PMID = 16989664.001).
  • [ISSN] 1474-760X
  • [Journal-full-title] Genome biology
  • [ISO-abbreviation] Genome Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC1794547
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7. Otmani N, Khattab M: Metastatic neuroblastoma to the mandible in a 3-year-old boy: a case report. Med Oral Patol Oral Cir Bucal; 2007 May;12(3):E201-4
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  • [Title] Metastatic neuroblastoma to the mandible in a 3-year-old boy: a case report.
  • Although neuroblastoma is a relatively common malignancy of childhood and its dissemination to distant organs is often seen, metastasis to the mandible is rare.
  • A 3-year-old boy which a mandibular soft tissue mass was the initial presenting symptom of disseminated neuroblastoma is reported.
  • The results of biopsy were inconclusive and the differential diagnosis from the imaging studies included lymphoma, soft tissue sarcoma, and osteosarcoma.
  • A metastatic work-up disclosed neuroblastoma of the adrenal gland origin with osseous and bone marrow metastases.
  • This case illustrates that neuroblastoma at a young age, with bone metastases and bone marrow involvement are predictive of the poor outcome of the disease.
  • Therefore, detecting early stage metastasis is one of the essential factors for improving treatment of neuroblastoma patients.
  • [MeSH-major] Mandibular Neoplasms / secondary. Neuroblastoma / secondary
  • [MeSH-minor] Adrenal Gland Neoplasms / pathology. Child, Preschool. Fatal Outcome. Humans. Male. Neoplasm Staging / standards

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  • (PMID = 17468714.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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8. Stefanowicz J, Izycka-Swieszewska E, Drozyńska E, Pienczk J, Połczyńska K, Czauderna P, Sierota D, Bień E, Stachowicz-Stencel T, Kosiak W, Balcerska A: Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics. Folia Neuropathol; 2008;46(3):176-85
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  • [Title] Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics.
  • The suprarenal gland was the primary localization of the tumour in 3 of the children and in one the tumour was located in the retroperitoneal area.
  • The group included two ganglioneuroblastomas, one ganglioneuroma and one differentiating neuroblastoma.
  • Children with OMA and neuroblastoma despite a good oncological prognosis often present permanent neurological and developmental deficits.


9. Desai G, Filly RA, Rand L: Prenatal detection of an extra-adrenal neuroblastoma with hepatic metastases. J Ultrasound Med; 2009 Aug;28(8):1085-90
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  • [Title] Prenatal detection of an extra-adrenal neuroblastoma with hepatic metastases.
  • [MeSH-major] Fetal Diseases / diagnosis. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Magnetic Resonance Imaging / methods. Neuroblastoma / diagnosis. Neuroblastoma / secondary. Prenatal Diagnosis / methods


10. Wang J, Pei G, Yan J, Zhang G: Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. J Pediatr Hematol Oncol; 2009 Dec;31(12):983-4
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  • [Title] Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer.
  • A 4-month girl presenting with a giant mass in left adrenal region and multiple hepatic nodules was hospitalized.
  • On the basis of computed tomography, ultrasound and epidemiology we preferred the diagnosis of a left adrenal neuroblastoma accompanied with multiple hepatic metastases preoperatively.
  • But postoperative diagnosis was hemangiomatosis characterized by synchronous presence of a giant splenic hemangioma and multiple hepatic hemangiomas.
  • We think that it is deservedly reported because of not only its rarity but also pitfalls of preoperative differential diagnosis and management principle.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neuroblastoma / diagnosis. Splenic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Ultrasonography


11. Berrebi D, Lebras MN, Belarbi N, Couturier J, Fattet S, Faye A, Peuchmaur M, de Lagausie P: Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome. J Pediatr Surg; 2006 Jan;41(1):e11-4
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  • [Title] Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome.
  • Such association led quickly to the diagnosis of FA.
  • At age of 11 months, she developed simultaneously a renal tumor in a horseshoe kidney and bilateral adrenal tumors.
  • The left adrenal mass was removed, and partial nephrectomy was performed.
  • Histological analysis concluded to adrenal neuroblastoma and nephroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Fanconi Anemia / complications. Kidney Neoplasms / pathology. Neuroblastoma / pathology. Wilms Tumor / pathology


12. Chacko J, Karl S, Sen S, Eapen A, Mathai J: Bilateral cystic adrenal neuroblastoma with cystic metastasis in the liver. J Pediatr Surg; 2007 Aug;42(8):E11-3
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  • [Title] Bilateral cystic adrenal neuroblastoma with cystic metastasis in the liver.
  • Ultrasound and computerized tomography showed a large cystic lesion in the right adrenal, small cysts in the left adrenal, and multiple cystic liver metastases.
  • The right adrenal cyst, on excision, turned out to be a cystic neuroblastoma with hemorrhage.
  • On follow-up, the cysts in the left adrenal and the liver metastases are regressing.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Liver Neoplasms / diagnosis. Neuroblastoma / diagnosis

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  • (PMID = 17706480.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Schalk E, Mohren M, Koenigsmann M, Buhtz P, Franke A, Jentsch-Ullrich K: Metastatic adrenal neuroblastoma in an adult. Onkologie; 2005 Jun;28(6-7):353-5
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  • [Title] Metastatic adrenal neuroblastoma in an adult.
  • BACKGROUND: Neuroblastoma (NB) is a common malignancy in children, but rarely occurs in adults.
  • In adults, abdomen/retroperitoneum are the primary sites and in children the adrenal gland.
  • Tumour resection revealed adrenal NB grade III.
  • Chemotherapy according to the paediatric German Neuroblastoma Trial (NB97) was started.
  • The patient died 9 months after diagnosis.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neuroblastoma / pathology. Neuroblastoma / secondary

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  • (PMID = 15933424.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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14. Horiuchi A, Watanabe Y, Miyauchi K, Kawachi K, Ishida Y, Tokuda K, Tauchi H: Prenatally detected cystic adrenal neuroblastoma. Pediatr Int; 2008 Feb;50(1):130-1
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  • [Title] Prenatally detected cystic adrenal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Cysts / pathology. Female. Humans. Infant, Newborn. Male. Pregnancy. Prenatal Diagnosis

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  • (PMID = 18279224.001).
  • [ISSN] 1328-8067
  • [Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society
  • [ISO-abbreviation] Pediatr Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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15. Genc H, Haciyanli M, Haciyanli SG, Gelal F, Avci Uçarsoy A, Dag F: An adult adrenal neuroblastoma: a case report. Acta Chir Belg; 2005 Nov-Dec;105(6):673-6
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  • [Title] An adult adrenal neuroblastoma: a case report.
  • Neuroblastoma of the adrenal gland is an extremely rare tumour in adulthood although it is one of the most common malignancies in childhood.
  • In this report, we present a 52-year-old man who had a left adrenal mass on preoperative imaging.
  • The histopathological examination of the specimen revealed the diagnosis of neuroblastoma.
  • He had no metastatic disease at the time of diagnosis and received chemotherapy after the operation.
  • Although neuroblastoma of adrenal gland is rare in adulthood, it should be considered in the differential diagnosis for patients with adrenal masses.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis

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  • (PMID = 16438086.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 5001-33-2 / Metanephrine; 55-10-7 / Vanilmandelic Acid
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16. Köksal Y, Varan A, Kale G, Tanyel FC, Büyükpamukçu M: Bilateral adrenal cystic neuroblastoma with hepatic and splenic involvement in a newborn. J Pediatr Hematol Oncol; 2005 Dec;27(12):670-1
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  • [Title] Bilateral adrenal cystic neuroblastoma with hepatic and splenic involvement in a newborn.
  • Bilateral cystic adrenal neuroblastoma is an unusual variant of neuroblastoma, and only two cases have been reported in the neonatal period until now.
  • The authors describe a newborn with splenic and hepatic involvement of bilateral adrenal cystic neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / congenital. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / secondary. Neuroblastoma / congenital. Splenic Neoplasms / secondary

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  • (PMID = 16344674.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Patterson AR, Barker CS, Loukota RA, Spencer J: Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma. Int J Oral Maxillofac Surg; 2009 Feb;38(2):196-8
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  • [Title] Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma.
  • Neuroblastoma, ganglioneuroblastoma and ganglioneuroma are neuroblastic tumours derived from primordial neural crest tissue.
  • The authors report a rare presentation of a ganglioneuroma of the mandible arising from a metastasis of an adrenal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Ganglioneuroblastoma / pathology. Ganglioneuroma / radiography. Mandibular Neoplasms / secondary. Neoplasms, Neuroepithelial / secondary. Neuroblastoma / secondary

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  • (PMID = 19019630.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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18. Meersman A, Wojciechowski M, Vaneerdeweg W, Jorens P, Michiels E, Ramet J: Acute retroperitoneal hemorrhage and shock as presenting signs of neuroblastoma in an infant. Pediatr Emerg Care; 2008 Jan;24(1):37-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute retroperitoneal hemorrhage and shock as presenting signs of neuroblastoma in an infant.
  • Adrenal hemorrhage after the neonatal period is rare.
  • Spontaneous bleeding within an adrenal neuroblastoma has been described, but acute massive hemorrhage is exceptional.
  • We describe a case of neuroblastoma of the adrenal gland presenting with acute life-threatening abdominal hemorrhage.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemoperitoneum / diagnosis. Neuroblastoma / diagnosis. Shock, Hemorrhagic / diagnosis
  • [MeSH-minor] Acute Disease. Diagnosis, Differential. Emergency Service, Hospital. Follow-Up Studies. Humans. Infant. Laparotomy / methods. Lymphatic Metastasis. Male. Risk Assessment. Rupture, Spontaneous. Tomography, X-Ray Computed. Treatment Outcome. Wilms Tumor / diagnosis

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  • (PMID = 18212608.001).
  • [ISSN] 1535-1815
  • [Journal-full-title] Pediatric emergency care
  • [ISO-abbreviation] Pediatr Emerg Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Sorrentino S, Conte M, Nozza P, Granata C, Capra V, Avanzini S, Garaventa A: Simultaneous occurrence of pancreatoblastoma and neuroblastoma in a newborn with beckwith-wiedemann syndrome. J Pediatr Hematol Oncol; 2010 Jul;32(5):e207-9
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  • [Title] Simultaneous occurrence of pancreatoblastoma and neuroblastoma in a newborn with beckwith-wiedemann syndrome.
  • We report the case of a newborn with Beckwith-Wiedemann syndrome presenting the simultaneous occurrence of a cystic pancreatoblastoma and an adrenal neuroblastoma.
  • Surgery was required to treat the pancreatoblastoma, and a "wait and see" policy was adopted for the neuroblastoma, which spontaneously regressed within a few months.
  • [MeSH-major] Beckwith-Wiedemann Syndrome / etiology. Neoplasms, Multiple Primary / etiology. Neuroblastoma / etiology. Pancreatic Cyst / etiology. Pancreatic Neoplasms / etiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Infant, Newborn. Male. Pregnancy. Prognosis. Tomography, X-Ray Computed. Ultrasonography, Prenatal


20. Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Nakao K, Maitani Y: Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma. Int J Oncol; 2010 Sep;37(3):695-705
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma.
  • Adrenal neuroblastoma and pheochromocytoma have the same embryonic origin from neural crest cells and mainly arise from the adrenal medulla.
  • Recently, transgenic mice exhibiting tumors in the bilateral adrenal medulla by the expression of SV40 T-antigen were developed.
  • In this study, we investigated mRNA expression in adrenal tumors of transgenic mice and compared them with human pheochromocytoma by DNA microarray analysis.
  • To compare mouse adrenal tumors and human pheochromacytoma, we found that the expressions of noradrenergic neuron-related genes, including dopa decarboxylase, phenylethanolamine-N-methyltransferase and chromogranin B, were up-regulated in humans but not in mice; however, the expression of neuroblastoma-related genes, including Mycn, paired-like homeobox 2b, gamma-aminobutyric acid A receptor beta3 subunit, islet 1 and kinesin family member 1A, was up-regulated in both species.
  • From the gene expression profiles, the characterization of mouse adrenal tumor, may be similar to that of human adrenal neuroblastoma rather than pheochromacytomas.
  • This mouse model would be a useful tool for the development of anti-cancer drugs and for understanding the etiology of adrenal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics


21. Raveenthiran V, Cenita S, Viswanathan P: Stabler's sign revisited in a spontaneously ruptured neuroblastoma of the newborn. Am J Perinatol; 2008 Jan;25(1):17-20
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  • [Title] Stabler's sign revisited in a spontaneously ruptured neuroblastoma of the newborn.
  • Spontaneous adrenal hemorrhage is the most common cause of nontraumatic parietal ecchymosis sign in neonates.
  • We report the sign for the first time in a case of spontaneously ruptured adrenal neuroblastoma of newborn.
  • Perinatal physicians need to be aware of this unusual presentation of neonatal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Ecchymosis / etiology. Neuroblastoma / pathology

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  • (PMID = 18050035.001).
  • [ISSN] 0735-1631
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Seefelder C, Sparks JW, Chirnomas D, Diller L, Shamberger RC: Perioperative management of a child with severe hypertension from a catecholamine secreting neuroblastoma. Paediatr Anaesth; 2005 Jul;15(7):606-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perioperative management of a child with severe hypertension from a catecholamine secreting neuroblastoma.
  • We report the perioperative management of a 5 year old child with stage III adrenal neuroblastoma who presented with malignant hypertension and high norepinephrine and dopamine levels.
  • [MeSH-major] Catecholamines / metabolism. Catecholamines / physiology. Hypertension / etiology. Hypertension / therapy. Kidney Neoplasms / complications. Kidney Neoplasms / metabolism. Neuroblastoma / complications. Neuroblastoma / metabolism


23. Avni FE, Massez A, Cassart M: Tumours of the fetal body: a review. Pediatr Radiol; 2009 Nov;39(11):1147-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adrenal neuroblastoma is the commonest malignant tumour.
  • [MeSH-major] Fetal Diseases / diagnosis. Magnetic Resonance Imaging / methods. Neoplasms / congenital. Neoplasms / diagnosis. Prenatal Diagnosis / methods. Ultrasonography / methods


24. Pellkofer HL, Voltz R, Goebels N, Hohlfeld R, Dornmair K: Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue. Arch Neurol; 2009 May;66(5):655-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: According to established criteria, paraneoplastic encephalomyelitis with adrenal neuroblastoma comprises a definite paraneoplastic neurologic syndrome.
  • Patient A 22-year-old woman having paraneoplastic encephalomyelitis with adrenal neuroblastoma.
  • MAIN OUTCOME MEASURES: We compared the T-cell receptor repertoires expressed in blood, cerebrospinal fluid, and neuroblastoma tumor tissue using complementary determining region 3 (CDR3) spectratyping and clone-specific polymerase chain reaction.
  • [MeSH-major] Adrenal Gland Neoplasms / immunology. Neuroblastoma / immunology. Paraneoplastic Syndromes, Nervous System / immunology. Receptors, Antigen, T-Cell / analysis
  • [MeSH-minor] Antigens, Neoplasm / analysis. Antigens, Neoplasm / classification. Biomarkers / analysis. Biomarkers / blood. Biomarkers / cerebrospinal fluid. Cell Lineage / immunology. Clone Cells / immunology. Cross Reactions / immunology. Female. Humans. Immunophenotyping. Lymphocyte Activation / immunology. Receptors, Antigen, T-Cell, alpha-beta / analysis. T-Lymphocyte Subsets / immunology. T-Lymphocytes / classification. T-Lymphocytes / immunology. Young Adult

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  • [CommentIn] Arch Neurol. 2009 Oct;66(10):1299-300; author reply 300 [19822792.001]
  • (PMID = 19433667.001).
  • [ISSN] 1538-3687
  • [Journal-full-title] Archives of neurology
  • [ISO-abbreviation] Arch. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers; 0 / Receptors, Antigen, T-Cell; 0 / Receptors, Antigen, T-Cell, alpha-beta
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25. Johnston DL, Sweeney B, Halton JM: Bilateral adrenal neuroblastoma: stage V disease. J Pediatr Hematol Oncol; 2007 Sep;29(9):652-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral adrenal neuroblastoma: stage V disease.
  • Neuroblastoma frequently arises from the adrenal gland and has rarely been reported to arise synchronously in both adrenal glands.
  • The majority of reports of bilateral adrenal neuroblastoma are in children under the age of 1 year.
  • We present a case of bilateral adrenal neuroblastoma in an 8-year-old child.
  • This is the first report of bilateral disease in a child over the age of 1 year with stage IV neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Child. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging

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  • [CommentIn] J Pediatr Hematol Oncol. 2008 May;30(5):408-9 [18458582.001]
  • (PMID = 17805045.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Tanaka M, Kato K, Gomi K, Matsumoto M, Kudo H, Shinkai M, Ohama Y, Kigasawa H, Tanaka Y: Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma. Am J Surg Pathol; 2009 Sep;33(9):1416-20
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  • [Title] Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma.
  • We report a case of perivascular epithelioid cell tumor (PEComa) with an SFPQ/PSF-TFE3 gene fusion in a 14-year-old girl treated for adrenal neuroblastoma for 4 years.
  • Imaging studies revealed a tumor in the wall of the sigmoid colon, which was radiologically different from the neuroblastoma, together with several inguinal and cervical lymph node metastases of the neuroblastoma.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Colonic Neoplasms / pathology. Neuroblastoma / secondary. Perivascular Epithelioid Cell Neoplasms / pathology

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  • (PMID = 19606011.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / PTB-associated splicing factor; 0 / RNA-Binding Proteins; 0 / TFE3 protein, human
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27. Boyd DT, Hayeri MR, Kadom N: Parotid metastasis from adrenal neuroblastoma. Pediatr Radiol; 2010 Dec;40 Suppl 1:S113-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid metastasis from adrenal neuroblastoma.
  • In contrast, salivary gland tumors are uncommon in children, accounting for only 1% of all pediatric neoplasms.
  • We present a case of a parotid metastasis from a neuroblastoma with in-depth description and discussion of its ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) appearances.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Diagnostic Imaging / methods. Neuroblastoma / diagnosis. Neuroblastoma / secondary. Parotid Neoplasms / diagnosis. Parotid Neoplasms / secondary


28. Pianovski MA, Maluf EM, de Carvalho DS, Ribeiro RC, Rodriguez-Galindo C, Boffetta P, Zancanella P, Figueiredo BC: Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. Pediatr Blood Cancer; 2006 Jul;47(1):56-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Several reports refer to an increased frequency of adrenal cortex tumors (ACT) among children in Southern Brazil, yet all data have been derived from hospital-based registries.
  • PROCEDURE: We reviewed all death certificates that mentioned ACT or adrenal neuroblastoma (NB) and which were reported to the Paraná State Department of Health between 1998 and 2003, for individuals younger than 15 years who resided in the Curitiba metropolitan region.
  • The ratio of the adrenal NB and ACT age-adjusted mortality rates was 1.43.
  • [MeSH-major] Adrenal Cortex Neoplasms / mortality
  • [MeSH-minor] Adolescent. Brazil / epidemiology. Child. Child, Preschool. Genes, p53 / genetics. Humans. Incidence. Infant. Infant, Newborn. Mutation. Neuroblastoma / mortality. Survival Rate

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16200634.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Gonçalves R, Linhares E, Albagli R, Valadão M, Vilhena B, Romano S, Ferreira CG: Occurrence of other tumors in patients with GIST. Surg Oncol; 2010 Dec;19(4):e140-3
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  • Immunohistological diagnosis was confirmed by a pathologist specialized in sarcomas.
  • The mean size of lesions was 4.79 cm (0.3-15 cm), with malignant potential low/very low in 7 cases (50%), intermediate in 5 cases (35.7%) and high in 2 cases (14.3%).
  • The diagnosis of GIST was incidental in 6 cases and in one case the non-GIST tumor was incidental.
  • The other sites involved were breast (ductal carcinoma), kidney (clear cell carcinoma), prostate (adenocarcinoma), endometrium (adenocarcinoma), ovary (adenocarcinoma) and adrenal (neuroblastoma), with one case each.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20675121.001).
  • [ISSN] 1879-3320
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
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30. Araujo Júnior E, Sanchez Ayub E, Costa Santos EM, Moraes DJ, Rodrigues Pires C, Filho Sebastião MZ: [Prenatal ultrasound diagnosis of adrenal neuroblastoma]. Ginecol Obstet Mex; 2005 Aug;73(8):451-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prenatal ultrasound diagnosis of adrenal neuroblastoma].
  • [Transliterated title] Diagnóstico prenatal ultrasonográfico de neuroblastoma adrenal.
  • Neuroblastoma is the most frequent solid malignant tumor in the neonatal period; however, its diagnosis is very difficult in the prenatal one.
  • The antenatal ultrasound diagnosis is possible by finding a mixed mass in the adrenal gland.
  • We report a case of a bilateral adrenal neuroblastoma diagnosed by antenatal ultrasonography at the 29th week of gestation.
  • [MeSH-major] Adrenal Gland Neoplasms / ultrasonography. Fetal Diseases / ultrasonography. Neuroblastoma / ultrasonography. Ultrasonography, Prenatal


31. Alsultan A, Lovell MA, Hayes KL, Allshouse MJ, Garrington TP: Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. Pediatr Blood Cancer; 2008 Nov;51(5):695-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome.
  • We present the case of an infant with BWS who has hypomethylation of LIT1 gene in the 11p15.5 chromosomal region and at 6 months of age presented with simultaneous occurrence of neuroblastoma arising from the left adrenal gland and a right adrenocortical tumor.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenal Gland Neoplasms / complications. Beckwith-Wiedemann Syndrome / complications. Neoplasms, Multiple Primary / complications. Neuroblastoma / complications


32. Tatekawa Y, Muraji T, Nishijima E, Yoshida M, Tsugawa C: Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report. J Pediatr Surg; 2006 Feb;41(2):443-5
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  • [Title] Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report.
  • Screening abdominal ultrasonography showed a 6-cm-sized mass in the left adrenal gland.
  • Metaiodobenzyl guanidine I 123 scintigram, abdominal computed tomography, and abdominal magnetic resonance imaging revealed only left adrenal tumor with no metastasis.
  • Left adrenalectomy was performed transperitoneally, and histopathological diagnosis was an adrenal composite pheochromocytoma associated with neuroblastoma.
  • Immunoreactivity for vimentin was positive in pheochromocytoma, which was negative in neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neuroblastoma / pathology. Pheochromocytoma / pathology


33. Janjanin N, Dumic M, Skrabic V, Kusec V, Grubic Z, Spehar Uroic A: Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family. Horm Res; 2007;67(3):111-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family.
  • CASE REPORT: We present 5 patients with congenital adrenal hyperplasia (CAH) due to 21-OHD belonging to the 3 generations of the same family (grandmother, parents and their 2 children).
  • The probands' mother, besides the nonclassical 21-OHD, also had neuroblastoma of the adrenal gland.
  • The occurrence of neuroblastoma with 21-OHD may support the hypothesis that an impairment in the synthesis and secretion of glucocorticoids may play role in the development and functioning of the adrenal medulla.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Hyperplasia, Congenital / diagnosis. Neuroblastoma / complications. Steroid 21-Hydroxylase


34. Messina M, Di Maggio G, Garzi A, Molinaro F, Amato G, Ferrara F: [Neonatal neuroblastoma and prenatal diagnosis]. Minerva Pediatr; 2009 Jun;61(3):349-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neonatal neuroblastoma and prenatal diagnosis].
  • [Transliterated title] Neuroblastoma neonatale e diagnosi pre-natale.
  • The authors present a case of neonatal neuroblastoma diagnosed in prenatal age and managed with a multidisciplinary approach.
  • The echographic morphological prenatal diagnosis showed an abdominal mass of 3x2 cm located on the upper side of the kidney, which was not apparently involved.
  • Postnatal ultrasound evaluations confirmed that diagnosis.
  • These exams confirmed the presence of a mass, probably due to a neuroblastoma.
  • The histological examination confirmed the diagnosis of neuroblastoma Stage I without medullary involvement.
  • In conclusion, the effectiveness of a multidisciplinary approach of neonatal neuroblastoma is higher in the early diagnosis and in an accurate staging of the disease, which is fundamental for the favourable prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis. Prenatal Diagnosis
  • [MeSH-minor] 3-Iodobenzylguanidine. Diagnosis, Differential. Humans. Infant, Newborn. Magnetic Resonance Spectroscopy. Neoplasm Staging. Radioisotope Renography / methods. Radiopharmaceuticals. Treatment Outcome. Ultrasonography, Prenatal


35. Drozyńska E, Izycka-Swieszewska E, Balcerska A, Bodalski J, Bohosiewicz J, Brozyna A, Bubała H, Chybicka A, Grajkowska W, Koltan S, Madziara W, Rybczyńska A, Słociak M, Sońta-Jakimczyk D, Stolarska M, Perek D, Wachowiak J, Wysocki M: [Analysis of microvascular density and the expression of vascular-endothelial growth factor (VEGF) and its membrane receptor Flk-1 in neuroblastoma]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 1):745-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of microvascular density and the expression of vascular-endothelial growth factor (VEGF) and its membrane receptor Flk-1 in neuroblastoma].
  • [Transliterated title] Analiza gestości naczyniowej oraz ekspresji śródbłonowo-naczyniowego czynnika wzrostu (VEFG) i jego receptora błonowego (FLK-1) w neuroblastoma.
  • AIM: To assess selected angiogenic markers; microvascular density and the expression of VEGF and Flk-1 in relation to clinical features and morphologic types of neuroblastoma.
  • PATIENTS AND METHODS: Eighty-two children with neuroblastoma were studied.
  • The results of angiogenic studies were referred to the clinical data: age, clinical stage, localization and site of the primary tumour, serum LDH and ferritin at diagnosis.
  • The correlation between angiogenic markers and morphological type of neuroblastoma was also evaluated.
  • The highest expression of VEGF was found in adrenal tumours in comparison to other localizations.
  • Neuroblastoma tumours arising in small children and poorly differentiated types of neuroblastoma indicate higher angiogenic activity.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neuroblastoma / blood supply. Neuroblastoma / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor Receptor-2 / metabolism

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  • (PMID = 17317905.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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36. Rabah R, Weber R, Serhatkulu GK, Cao A, Dai H, Pandya A, Naik R, Auner G, Poulik J, Klein M: Diagnosis of neuroblastoma and ganglioneuroma using Raman spectroscopy. J Pediatr Surg; 2008 Jan;43(1):171-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of neuroblastoma and ganglioneuroma using Raman spectroscopy.
  • BACKGROUND: Raman spectroscopy has proven to be useful in studying premalignant and malignant lesions in adults.
  • This is the first report to evaluate Raman spectroscopy in the diagnosis and classification of neuroblastoma in children.
  • METHODS: A biopsy or resection of fresh tissue samples from normal adrenal glands, neuroblastomas, ganglioneuromas, nerve sheath tumors, and pheochromocytoma at our hospital were equally divided between routine histology and spectroscopic studies.
  • RESULTS: We collected 698 spectra from 16 neuroblastomas, 5 ganglioneuromas, 3 normal adrenal glands, 6 nerve sheath tumors, and 1 pheochromocytoma.
  • Raman spectroscopy differentiated between normal adrenal gland, and neuroblastoma and ganglioneuroma with 100% sensitivity and 100% specificity.
  • It was also able to differentiate neuroblastoma from nerve sheath tumors and pheochromocytoma with high sensitivity and specificity.
  • CONCLUSION: This technique can differentiate neuroblastoma from ganglioneuroma and other tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Ganglioneuroma / diagnosis. Neuroblastoma / diagnosis. Pheochromocytoma / diagnosis. Spectrum Analysis, Raman / methods
  • [MeSH-minor] Biopsy, Needle. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Male. Sampling Studies. Sensitivity and Specificity. Tissue Embedding


37. Auber F, Larroquet M, Bonnard A, Boudjemaa S, Landman-Parker J, Ducou Le Pointe H, Boccon-Gibod L, Lefebvre G, Uzan S, Hélardot P, Audry G: [Prenatal ultrasound diagnosis of neuroblastoma]. Gynecol Obstet Fertil; 2005 Apr;33(4):228-31
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  • [Title] [Prenatal ultrasound diagnosis of neuroblastoma].
  • With the progress of foetal ultrasonography, diagnosis of foetal tumors can be made before birth.
  • We report five cases of prenatally detected neuroblastoma of the adrenal glands.
  • Diagnosis was made during the third trimester in all cases.
  • In each setting the tumor was a stage I neuroblastoma according to the Evans classification.
  • [MeSH-major] Adrenal Gland Neoplasms / ultrasonography. Fetal Diseases / ultrasonography. Neuroblastoma / ultrasonography. Ultrasonography, Prenatal


38. Gambini JP, López Lerena JJ, Quagliata A, Hermida JC, Heuguerot C, Alonso O: 99mTc-HYNIC octreotide in neuroblastoma. Ann Nucl Med; 2008 Nov;22(9):817-9
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  • [Title] 99mTc-HYNIC octreotide in neuroblastoma.
  • Disease status assessment of neuroblastoma patients requires computed tomography (or magnetic resonance imaging), bone scan, metaiodobenzylguanidine (MIBG) scan, bone marrow tests, and urine catecholamine measurements.
  • An 8-year-old boy already diagnosed with stage-IV neuroblastoma received chemotherapy.
  • Therefore, 99mTc-HYNIC-octreotide may be a promising radiopharmaceutical for the evaluation of neuroblastoma patients.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Gland Neoplasms / radionuclide imaging. Neuroblastoma / radionuclide imaging. Octreotide / analogs & derivatives. Organotechnetium Compounds

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  • (PMID = 19039561.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; 35MRW7B4AD / 3-Iodobenzylguanidine; RWM8CCW8GP / Octreotide
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39. Nuchtern JG: Perinatal neuroblastoma. Semin Pediatr Surg; 2006 Feb;15(1):10-6
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  • [Title] Perinatal neuroblastoma.
  • Over the past two decades, routine prenatal ultrasound has significantly increased the rate of diagnosis of fetal neuroblastoma.
  • More than 90% of these tumors arise in the adrenal gland, suggesting a link between perinatal tumors and the nodular collections of neuroblasts that are part of normal adrenal development.
  • In fact, there is compelling evidence that the cystic variant of perinatal neuroblastoma is caused by a perturbation of the involution program of these neuroblastic nodules.
  • The ultimate goal of such studies is to define an ultra-low-risk group of neuroblastoma patients who do not require invasive procedures or chemotherapy to achieve an excellent outcome.
  • [MeSH-major] Fetal Diseases / diagnosis. Fetal Diseases / physiopathology. Neuroblastoma / diagnosis. Neuroblastoma / physiopathology


40. Sherer DM, Dalloul M, Wagreich A, Sokolovski M, Duan H, Zinn H, Abulafia O: Prenatal sonographic findings of congenital adrenal cortical adenoma. J Ultrasound Med; 2008 Jul;27(7):1091-3
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  • [Title] Prenatal sonographic findings of congenital adrenal cortical adenoma.
  • The differential diagnosis of prenatally diagnosed adrenal masses includes neuroblastoma, adrenal hemorrhage, adrenal and cortical renal cysts, adrenal adenoma and carcinoma, subdiaphragmatic pulmonary sequestration, Beckwith-Wiedemann syndrome, duplication of the renal system, Wilms tumors, congenital mesoblastic nephroma, and mesenteric and enteric duplication cysts.
  • The worldwide annual incidence of childhood adrenal cortical neoplasms ranges between 0.3 and 0.38 per 1 million children younger than 15 years.
  • [MeSH-major] Adrenal Cortex Neoplasms / congenital. Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / congenital. Adrenocortical Adenoma / diagnosis. Ultrasonography, Prenatal / methods
  • [MeSH-minor] Adrenal Cortex / surgery. Adrenal Cortex / ultrasonography. Adult. Diagnosis, Differential. Female. Humans. Imaging, Three-Dimensional / methods. Infant, Newborn. Male. Pregnancy. Radiography, Abdominal / methods. Tomography, X-Ray Computed

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  • (PMID = 18577675.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Muhlstein J, Rodriguez-Dahlhoff S, Marie B, Fouyssac F: Primary ovarian neuroblastoma. J Pediatr Adolesc Gynecol; 2010 Oct;23(5):263-6
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  • [Title] Primary ovarian neuroblastoma.
  • BACKGROUND: The diagnosis of neuroblastoma is rare after the age of 15 years, and anatomical locations are essentially the adrenal glands and paraspinal sites.
  • CASE REPORT: We report the case of a 17-year-old young woman in whom the diagnosis of primary ovarian neuroblastoma associated with a mature teratoma was established.
  • [MeSH-major] Neoplasms, Second Primary / pathology. Neuroblastoma / pathology. Ovarian Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Neoplasm Staging

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  • [Copyright] Copyright 2010 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Pediatr Adolesc Gynecol. 2010 Oct;23(5):261-2 [20813329.001]
  • (PMID = 20371194.001).
  • [ISSN] 1873-4332
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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42. Avanzini S, Conte M, Granata C, Zamorani EM, Sementa AR, Garaventa A, Buffa P, Sorrentino S: Life-threatening bilateral adrenal cystic neuroblastoma in an infant. J Pediatr Hematol Oncol; 2009 Dec;31(12):963-4
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  • [Title] Life-threatening bilateral adrenal cystic neuroblastoma in an infant.
  • A case of neonatal bilateral adrenal mass causing severe respiratory distress and requiring an emergency debulking surgical procedure is reported.
  • Histopathology revealed a cystic neuroblastoma stroma poor, poorly differentiated, without MYCN amplification and 1p deletion.
  • Both adrenal masses and hepatic nodules showed progressive decrease in size, till complete disappearance.
  • The authors encourage a multidisciplinary approach to develop the best patient-related strategy for cystic neuroblastoma, thus reducing complications rate.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Cysts / pathology. Neuroblastoma / pathology. Respiratory Distress Syndrome, Newborn / diagnosis

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  • (PMID = 19887960.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Iwanaka T, Kawashima H, Uchida H: The laparoscopic approach of neuroblastoma. Semin Pediatr Surg; 2007 Nov;16(4):259-65
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  • [Title] The laparoscopic approach of neuroblastoma.
  • Neuroblastoma is one of the most common solid tumors, and the biopsy and excision of this tumor are often required as part of a planned multimodal treatment.
  • In 1995, Holcomb and coworkers first reported endosurgical procedures for the diagnosis and treatment of pediatric malignancies; however, the usefulness of laparoscopic procedures for abdominal neuroblastoma is still unclear.
  • Twenty-five laparoscopic biopsies for advanced abdominal neuroblastoma and nine laparoscopic excisions for localized abdominal neuroblastoma performed at Saitama Children's Medical Center were evaluated.
  • Also, the blood loss of laparoscopic excision of localized neuroblastoma was significantly little compared with that of open excision.
  • Precise indications of laparoscopic procedure for the diagnosis and treatment of abdominal neuroblastoma provide better prognosis and quality of life for infants and children.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Neuroblastoma / surgery
  • [MeSH-minor] Algorithms. Child. Child, Preschool. Female. Hemostasis, Surgical. Humans. Infant. Laparoscopy. Lymph Node Excision. Male. Neoplasm Seeding. Tomography, X-Ray Computed

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  • (PMID = 17933668.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Rossbach HC, Baschinsky D, Wynn T, Obzut D, Sutcliffe M, Tebbi C: Composite adrenal anaplastic neuroblastoma and virilizing adrenocortical tumor with germline TP53 R248W mutation. Pediatr Blood Cancer; 2008 Mar;50(3):681-3
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  • [Title] Composite adrenal anaplastic neuroblastoma and virilizing adrenocortical tumor with germline TP53 R248W mutation.
  • Such tumors in adrenal glands are usually of neuroendocrine-neural type and occur mostly in adults.
  • We report a patient with composite neuroblastoma (NB), adrenocortical tumor (ACT), and Li-Fraumeni syndrome (LFS) with germline TP53 R248W mutation.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenal Gland Neoplasms / pathology. Adrenocortical Adenoma / pathology. Genes, p53. Germ-Line Mutation. Li-Fraumeni Syndrome / genetics. Mutation, Missense. Neoplasms, Multiple Primary / pathology. Neuroblastoma / pathology. Point Mutation. Virilism / etiology

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17427234.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Johnsen JI, Lindskog M, Ponthan F, Pettersen I, Elfman L, Orrego A, Sveinbjörnsson B, Kogner P: NSAIDs in neuroblastoma therapy. Cancer Lett; 2005 Oct 18;228(1-2):195-201
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  • [Title] NSAIDs in neuroblastoma therapy.
  • In neuroblastoma it has been shown that the majority of primary tumours and cell lines express high levels of COX-2, whereas normal adrenal medullas from children do not express COX-2.
  • Treatment of neuroblastoma cells with nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX, induces caspase-dependent apoptosis via the intrinsic mitochondrial pathway.
  • Established neuroblastoma xenografts in nude rats treated with the dual COX-1/COX-2 inhibitor, diclofenac, or the COX-2 specific inhibitor, celecoxib significantly inhibits neuroblastoma growth in vivo.
  • In vitro, arachidonic acid and diclofenac synergistically induces neuroblastoma cell death.
  • Proton MR-spectroscopy (1H MRS) of neuroblastoma cells treated with COX-inhibitors demonstrates accumulation of polyunsaturated fatty acids and depletion of choline compounds.
  • Thus, 1H MRS, which can be performed with clinical MR-scanners, is likely to provide pharmacodynamic markers of neuroblastoma response to COX-inhibition.
  • Taken together, these data suggest the use of NSAIDs as a novel adjuvant therapy for children with neuroblastoma.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Neuroblastoma / drug therapy

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  • (PMID = 15975708.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase Inhibitors
  • [Number-of-references] 38
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46. Leclair MD, de Lagausie P, Becmeur F, Varlet F, Thomas C, Valla JS, Petit T, Philippe-Chomette P, Mure PY, Sarnacki S, Michon J, Heloury Y: Laparoscopic resection of abdominal neuroblastoma. Ann Surg Oncol; 2008 Jan;15(1):117-24
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  • [Title] Laparoscopic resection of abdominal neuroblastoma.
  • BACKGROUND: Since indications for laparoscopic adrenalectomy have progressively expanded to pediatric surgery, preliminary reports have studied the laparoscopic approach for abdominal neuroblastoma (NB).
  • Primary site of the tumor was the adrenal gland in 41 cases and retroperitoneal space in 4.
  • CONCLUSION: Laparoscopic resection of abdominal primary allows effective local control of the disease in a wide range of clinical situations of neuroblastoma, with an acceptable morbidity.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Laparoscopy. Neuroblastoma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Humans. Infant. Infant, Newborn. Male. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17926102.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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47. Quackenbush KE, Luna-Fineman S, Magee JF, Gundogan M, Golobi M, Irie T, Fernandez CV: Neuroblastoma involvement of the falx cerebri. Pediatr Blood Cancer; 2009 Dec 15;53(7):1337-9
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  • [Title] Neuroblastoma involvement of the falx cerebri.
  • Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare.
  • The falx is derived from the neural crest and thus may be a location for primary neuroblastoma.
  • Management of neuroblastoma in this location is potentially challenging.
  • We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dura Mater / pathology. Meningeal Neoplasms / secondary. Neuroblastoma / secondary
  • [MeSH-minor] Adrenalectomy. Carboplatin / administration & dosage. Cell Lineage. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Infant. Infant, Newborn. Male. Microphthalmia-Associated Transcription Factor / genetics. Neoplasm Staging. Neural Crest. Pulmonary Veins / abnormalities. Remission Induction. Skin Neoplasms / drug therapy. Skin Neoplasms / secondary. Waardenburg Syndrome / complications. Waardenburg Syndrome / genetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19821537.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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48. Kazanowska B, Reich A, Jelen M, Chybicka A: Chronic metastatic neuroblastoma. Pediatr Blood Cancer; 2008 Apr;50(4):898-900
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  • [Title] Chronic metastatic neuroblastoma.
  • The diversity of neuroblastoma and its clinical course depends on histology, biology and clinical features.
  • The diagnosis was made by histological examination of a subcutaneous nodule and elevated urinary markers.
  • We suggest the use of the "chronic neuroblastoma" as a term to describe patients with neuroblastoma showing indolent disease course over a very long period of time, but never achieving complete remission.
  • [MeSH-major] Abdominal Neoplasms / pathology. Neuroblastoma / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / secondary. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Chronic Disease. Humans. Immunohistochemistry. Infant. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Male. Tretinoin / therapeutic use

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 17914736.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5688UTC01R / Tretinoin
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49. Normand C, Leblond P, Mazingue F, Nelken B, Defachelles AS, Bonnevalle M: A case of adrenal haemorrhage after minor trauma in a young child: think of neuroblastoma. Eur J Pediatr Surg; 2006 Oct;16(5):365-8
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  • [Title] A case of adrenal haemorrhage after minor trauma in a young child: think of neuroblastoma.
  • We report a case of neuroblastoma diagnosed after adrenal haemorrhage following a minor trauma in a thirteen-month-old boy.
  • Therefore when no accepted cause for AH can be found in a young child below the age of 5 years, it is important to look for a neuroblastoma and discuss the necessity of surgical exploration.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemorrhage / etiology. Neuroblastoma / diagnosis
  • [MeSH-minor] Accidental Falls. Adrenal Glands / blood supply. Fatal Outcome. Humans. Infant. Male. Tomography, X-Ray Computed

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  • (PMID = 17160786.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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50. Brouwers FM, Eisenhofer G, Lenders JW, Pacak K: Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma. Endocrinol Metab Clin North Am; 2006 Dec;35(4):699-724, viii
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  • [Title] Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma.
  • It is vital to think about this disease in any emergency situation when conventional therapy fails to achieve control or symptoms occur that do not fit the initial diagnosis.
  • The importance of keeping this diagnosis in minds is underscored by the fact that, in 50% of pheochromocytoma patients, the diagnosis is initially overlooked.
  • Two other tumors of the sympathetic nervous system, neuroblastoma and ganglioneuroma, are less commonly associated with emergency conditions.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Ganglioneuroma / complications. Neuroblastoma / complications. Pheochromocytoma / complications

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  • (PMID = 17127142.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Number-of-references] 230
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51. Pastorino F, Marimpietri D, Brignole C, Di Paolo D, Pagnan G, Daga A, Piccardi F, Cilli M, Allen TM, Ponzoni M: Ligand-targeted liposomal therapies of neuroblastoma. Curr Med Chem; 2007;14(29):3070-8
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  • [Title] Ligand-targeted liposomal therapies of neuroblastoma.
  • Until recently, the most resorted experimental model of paediatric Neuroblastoma (NB) tumour is the subcutaneous xenograft in nude mice.
  • A more realistic view of the clinical potential of targeted therapies could be obtained if a tumour model were available that better reflects the growth of advanced NB in children (i.e. large adrenal gland tumours and multiple small metastatic lesions).
  • This review will focus on the description of the most clinically relevant animal models established to test the efficacy of targeted liposomal anti-tumour formulations for the treatment of Neuroblastoma.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Neuroblastoma / drug therapy
  • [MeSH-minor] Animals. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cell Line, Tumor. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Drug Delivery Systems. Humans. Ligands. Liposomes. Neoplasm Transplantation. Oligonucleotides, Antisense / administration & dosage. Oligonucleotides, Antisense / therapeutic use. Transplantation, Heterologous

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  • (PMID = 18220743.001).
  • [ISSN] 0929-8673
  • [Journal-full-title] Current medicinal chemistry
  • [ISO-abbreviation] Curr. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ligands; 0 / Liposomes; 0 / Oligonucleotides, Antisense; 80168379AG / Doxorubicin
  • [Number-of-references] 77
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52. Krona C, Carén H, Sjöberg RM, Sandstedt B, Laureys G, Kogner P, Martinsson T: Analysis of neuroblastoma tumour progression; loss of PHOX2B on 4p13 and 17q gain are early events in neuroblastoma tumourigenesis. Int J Oncol; 2008 Mar;32(3):575-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of neuroblastoma tumour progression; loss of PHOX2B on 4p13 and 17q gain are early events in neuroblastoma tumourigenesis.
  • The PHOX2B gene is implicated in the development of the autonomic nervous system and has been found to be infrequently mutated in sporadic neuroblastoma tumours and in some patients with hereditary neuroblastoma.
  • A constitutional heterozygous missense mutation was found in a boy who developed bilateral adrenal tumours and stage 4 disease during infancy.
  • Histopathological evaluation of the tumours suggested growth of two primary tumours, one with diploid DNA content and the other with tetraploid DNA content, i.e. a case of neuroblastoma stage 4M (multifocal tumour).
  • However, array CGH (comparative genomic hybridization) data performed on both tumour masses from the patient instead supported a model where a common malignant precursor gave rise to the diploid tumour and subsequently the tetraploid tumour have progressed from the common precursor or by metastasis from the diploid tumour with additional genetic changes.
  • Based on the data presented here we suggest that loss of PHOX2B and 17q gain are early events in neuroblastoma tumourigenesis.
  • [MeSH-major] Chromosomes, Human, Pair 17. Chromosomes, Human, Pair 4. Homeodomain Proteins / genetics. Neuroblastoma / genetics. Neuroblastoma / pathology. Transcription Factors / genetics

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  • (PMID = 18292934.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / NBPhox protein; 0 / RNA, Messenger; 0 / Transcription Factors
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53. Wu XR, Zhu MH, Zhang ZD: [Expression of KAI1/CD82 in neuroblastoma and its correlation to prognosis]. Ai Zheng; 2005 Jul;24(7):885-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of KAI1/CD82 in neuroblastoma and its correlation to prognosis].
  • Our study was designed to investigate the expression of KAI1/CD82 in neuroblastoma, and explore its correlation to clinicopathologic characteristics and prognosis of patients with neuroblastoma.
  • METHODS: The EnVision immunohistochemistry was used to detect the expression of KAI1/CD82 in 90 specimens of neuroblastoma (28 specimens of ganglioneuroblastoma and 62 specimens of neuroblastoma).
  • RESULTS: Positive rate of KAI1/CD82 was significantly higher in ganglioneuroblastoma than in neuroblastoma (39.3% vs. 14.5%, P=0.014).
  • Its expression was negatively correlated to clinical stage of neuroblastoma (P=0.003).
  • CONCLUSIONS: The change of KAI1/CD82 expression is an early event in tumorigenesis of neuroblastoma.
  • Its down-regulation may be considered as a potential indicator to judge the differentiation and metastasis of neuroblastoma, which can serve as one of the combined indexes to clinical assessment of prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Antigens, CD82 / metabolism. Ganglioneuroblastoma / metabolism. Neuroblastoma / metabolism. Peritoneal Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Lymphatic Metastasis. Lymphatic Vessels / metabolism. Male. Mediastinal Neoplasms / metabolism. Mediastinal Neoplasms / pathology. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 16004821.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD82; 0 / Biomarkers, Tumor
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54. Aktas S, Celebiler AC, Zadeoğlulari Z, Diniz G, Kargi A, Olgun N: Expression and methylation pattern of p16 in neuroblastoma tumorigenesis. Pathol Oncol Res; 2010 Mar;16(1):1-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and methylation pattern of p16 in neuroblastoma tumorigenesis.
  • Understanding migration, population and differentiation of primordial neural crest cells will help in evolving biology of neuroblastoma.
  • The aim of this study was to evaluate the role of p16 and its methylation pattern in neuroblastoma tumorigenesis.
  • P16 was studied in 5 samples of normal adrenal medullar tissue, 5 samples of adrenal tissue including blastic rests, 5 samples of neuroblastoma in situ tissue and in 8 samples of neuroblastoma tissues primary and after chemotherapy in each group.
  • The adrenal gland tissues were obtained from paediatric autopsy cases.
  • The mean age of neuroblastoma cases was 45 months.
  • P16 expression was positive in normal adrenal tissues, in one of 5 samples of adrenal blastic rest tissue and in all of samples of after chemotherapy; while no expression was observed in neuroblastoma and neuroblastoma in situ tissues.
  • P16 methylation was observed in samples of neuroblastoma in situ and primary neuroblastoma tissues.
  • Our results suggest that p16 and its methylation seems to play role in neuroblastoma tumorigenesis and in the migration, population and differentiation of primordial neural crest cells.
  • Inhibitors of DNA methylation may provide a useful tool for restoring p16 activity in neuroblastoma treatment.
  • [MeSH-major] DNA Methylation. Genes, p16. Neuroblastoma / genetics

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  • (PMID = 19466588.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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55. Al-Shammari NF, Redha E, Al Hajeri MH: Cervical neonatal neuroblastoma with recurrent SVT. Gulf J Oncolog; 2009 Jul;(6):45-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical neonatal neuroblastoma with recurrent SVT.
  • Neuroblastoma is the most common extracranial solid tumor of childhood and the third most common paediatric malignancy after leukemia and central nervous system (CNS) tumors.
  • Seventy five percent of neuroblastoma arise in the abdomen and pelvis, 20% in the thorax and 5% in the neck.
  • The median age at diagnosis is 22 months.
  • They occur most commonly in the adrenal medulla (35%).
  • Neuroblastomas also occur as primary tumors in the extra-adrenal retroperitoneum in 30% of cases, in the posterior mediastinum in 20% of cases , in the neck up to 5% of cases and in the pelvis in 5% of cases.
  • [MeSH-major] Head and Neck Neoplasms / complications. Neuroblastoma / complications. Tachycardia, Supraventricular / etiology

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  • (PMID = 20194085.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
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56. Allen AT, Dress AF, Moore WF: Mirror syndrome resulting from metastatic congenital neuroblastoma. Int J Gynecol Pathol; 2007 Jul;26(3):310-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mirror syndrome resulting from metastatic congenital neuroblastoma.
  • Neuroblastoma is a tumor of the sympathetic ganglia and adrenal medulla that rarely metastasizes to the placenta.
  • Pathological examination of the placenta revealed disseminated small round blue cells consistent with neuroblastoma.
  • Metastasis of congenital neuroblastoma to the placenta is exceedingly rare, and cases discovered prenatally have resulted in significant maternal morbidity and 100% neonatal mortality.
  • [MeSH-major] Hydrops Fetalis / pathology. Kidney Neoplasms / congenital. Kidney Neoplasms / pathology. Neuroblastoma / congenital. Placenta Diseases / pathology. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 17581417.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Raffaghello L, Prigione I, Bocca P, Morandi F, Camoriano M, Gambini C, Wang X, Ferrone S, Pistoia V: Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications. Oncogene; 2005 Jul 7;24(29):4634-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications.
  • Neuroblastoma cells are virtually HLA class I negative, but (i) the underlying mechanisms are unknown, and (ii) expression of the APM components has never been investigated.
  • Here we have used a panel of novel monoclonal antibodies to proteasomal and immunoproteasomal components, chaperons and transporter associated with antigen processing (TAP) to characterize 24 stroma-poor neuroblastoma tumors and six neuroblastoma cell lines.
  • Primary tumors showed defects in the expression of zeta, tapasin, TAP1 or TAP2, HLA class I heavy chain and beta2 microglobulin, LMP2 and LMP7, as compared to normal adrenal medulla.
  • Neuroblastoma cell lines displayed roughly similar patterns of APM expression in comparison to primary tumors.
  • Incubation of neuroblastoma cell lines with interferon-gamma caused upregulation of HLA class I molecules and reduced lysis by killer inhibitory receptor HLA ligand-matched NK cells.
  • HLA class I upregulation by interferon-gamma, although enhancing neuroblastoma cell recognition by cytotoxic T cells, dampens their susceptibility to NK cells.
  • [MeSH-major] HLA Antigens / biosynthesis. Interferon-gamma / biosynthesis. Neuroblastoma / immunology

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  • (PMID = 15897905.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 67108
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / HLA Antigens; 82115-62-6 / Interferon-gamma
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58. Carlson P, Jefferies JL, Kearney D, Russell H: Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer; 2010 Oct;55(4):736-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Refractory dilated cardiomyopathy associated with metastatic neuroblastoma.
  • Computerized tomography (CT) scan revealed a 7 cm adrenal lesion, confirmed as poorly differentiated neuroblastoma (NB).
  • [MeSH-major] Cardiomyopathy, Dilated / etiology. Neuroblastoma / complications


59. Zheng LD, Tong QS, Tang ST, Du ZY, Liu Y, Jiang GS, Cai JB: Expression and clinical significance of heparanase in neuroblastoma. World J Pediatr; 2009 Aug;5(3):206-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and clinical significance of heparanase in neuroblastoma.
  • However, the expression of HPA in neuroblastoma (NB), one of the most common extra cranial solid tumors in children, remains unknown.
  • The relationships among HPA expression, international neuroblastoma staging system (INSS) stages, histopathological classification, and postoperative survival of the NB patients were analyzed.
  • RESULTS: The expression rate of HPA in NB was 61.9% (26/42), mainly in the cytoplasm of neuroblastoma cells.
  • [MeSH-major] Adrenal Gland Neoplasms / enzymology. Glucuronidase / metabolism. Neuroblastoma / enzymology

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  • (PMID = 19693465.001).
  • [ISSN] 1708-8569
  • [Journal-full-title] World journal of pediatrics : WJP
  • [ISO-abbreviation] World J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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60. Rescorla FJ: Malignant adrenal tumors. Semin Pediatr Surg; 2006 Feb;15(1):48-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant adrenal tumors.
  • Adrenal tumors, apart from neuroblastoma, are relatively rare in infancy and childhood.
  • Most adrenal lesions are benign, and both benign and malignant tumors may be hormonally active thus, making accurate preoperative diagnosis difficult.
  • The two main malignant tumors are adrenocortical carcinoma and pheochromocytoma.
  • In both tumors, it may be difficult to determine benign from malignant and the biologic behavior and degree of invasion may portend a more malignant course.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Adrenocortical Carcinoma / diagnosis. Adrenocortical Carcinoma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy

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  • (PMID = 16458846.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 98
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61. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiological localizing techniques in adrenal tumors.
  • The characterisation of adrenal lesions is a common radiological dilemma.
  • Incidental adrenal lesions are commonly detected with computed tomography (CT), and lesion characterisation is critical.
  • The prevalence of incidental adrenal lesions has been reported to be 2.3% at autopsy and 0.5-2% with abdominal CT.
  • Although the majority of adrenal lesions are benign, in patients with an extra-adrenal primary cancer the probability of an adrenal mass being a metastasis is 52%.
  • Unfortunately, there may be significant overlap between the imaging appearances of benign lesions such as lipid-poor adenomas and malignant lesions, particularly metastases and small adrenal carcinomas.
  • This review highlights recent advances in radiological imaging of adrenal lesions and we discuss the relative merits of CT and magnetic resonance imaging to aid the identification of benign and malignant adrenal lesions and their roles, in combination with biochemical and clinical data, in recognizing common pathologies such as adrenal adenoma, phaeochromocytoma, carcinoma and metastases.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Incidental Findings. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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62. Castle V, Kwok R, Opipari A, Subramanian C: Ku70 acetylation in neuroblastoma pathogenesis and therapy. Trans Am Clin Climatol Assoc; 2010;121:183-91; discussion 191
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  • [Title] Ku70 acetylation in neuroblastoma pathogenesis and therapy.
  • Neuroblastoma is a cancer that occurs in children.
  • It develops from stem cells that normally give rise to parts of the peripheral nervous system and adrenal glands.
  • Although most children with localized neuroblastoma are cured, children with wide-spread disease have a small chance of survival even after surgery, chemotherapy, radiation and bone marrow transplantation.
  • To solve this problem, we are working to understand which molecules in the stem cells from which this cancer arises malfunction to cause neuroblastoma and apply this information to develop new models to treat this disease.
  • [MeSH-major] Antigens, Nuclear / metabolism. DNA-Binding Proteins / metabolism. Neuroblastoma / metabolism

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  • [Cites] Nat Cell Biol. 2003 Apr;5(4):320-9 [12652308.001]
  • [Cites] Lancet Oncol. 2003 Aug;4(8):472-80 [12901961.001]
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  • (PMID = 20697560.001).
  • [ISSN] 0065-7778
  • [Journal-full-title] Transactions of the American Clinical and Climatological Association
  • [ISO-abbreviation] Trans. Am. Clin. Climatol. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / BAX protein, human; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Histone Deacetylase Inhibitors; 0 / Ku autoantigen; 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC2917135
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63. Sudbrock F, Schmidt M, Simon T, Eschner W, Berthold F, Schicha H: Dosimetry for 131I-MIBG therapies in metastatic neuroblastoma, phaeochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging; 2010 Jul;37(7):1279-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dosimetry for 131I-MIBG therapies in metastatic neuroblastoma, phaeochromocytoma and paraganglioma.
  • Despite the significant role of the radiopharmaceutical (131)I-metaiodobenzylguanidine (MIBG) for the treatment of metastatic neuroblastoma, phaeochromocytoma and paraganglioma details for a reliable dosimetry are still sparse.
  • [MeSH-major] 3-Iodobenzylguanidine / therapeutic use. Adrenal Gland Neoplasms / radiotherapy. Neoplasm Metastasis / radiotherapy. Neuroblastoma / radiotherapy. Paraganglioma / radiotherapy. Pheochromocytoma / radiotherapy. Radiometry / methods

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  • (PMID = 20179922.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 35MRW7B4AD / 3-Iodobenzylguanidine
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64. Oguzkurt P, Ince E, Temiz A, Demir S, Akabolat F, Hicsonmez A: Prenatal diagnosis of a mass in the adrenal region that proved to be a teratoma. J Pediatr Hematol Oncol; 2009 May;31(5):350-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal diagnosis of a mass in the adrenal region that proved to be a teratoma.
  • Magnetic resonance imaging showed a 57 x 50 mm mass in the left adrenal region displacing the kidney inferiorly.
  • Prenatally detected suprarenal masses are likely to be neuroblastoma or adrenal hemorrhage, but may be rare benign lesions such as extralobar pulmonary sequestration, bronchogenic cyst, or renal dysplasia.
  • Although teratoma in the adrenal region is extremely rare, it should be included in the clinical and radiologic differential diagnosis of prenatally detected suprarenal masses.
  • Total excision of the mass for histologic diagnosis is indicated.
  • [MeSH-major] Adrenal Gland Neoplasms / congenital. Adrenal Gland Neoplasms / diagnosis. Teratoma / congenital. Teratoma / diagnosis. Ultrasonography, Prenatal
  • [MeSH-minor] Adrenalectomy. Biopsy. Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Pregnancy

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  • (PMID = 19415017.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Abramowsky CR, Katzenstein HM, Alvarado CS, Shehata BM: Anaplastic large cell neuroblastoma. Pediatr Dev Pathol; 2009 Jan-Feb;12(1):1-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic large cell neuroblastoma.
  • All patients presented with abdominal-pelvic masses, 3 of them of adrenal origin and 2 with thoracic extension, with clinical stages 3 or 4, and were considered to have high-risk disease.
  • Posttreatment biopsies showed maturation changes to more conventional neuroblastoma histology in 5 of the 7 cases.
  • Follow-up ranged from 9 months to 4 years from diagnosis (median: 25 months).
  • Five patients are still alive after treatment, 1 died 9 months after diagnosis, and another patient refused high-risk therapy and progressed and died 9 months from diagnosis.
  • Anaplastic large cell neuroblastomas are a subset of undifferentiated neuroblastomas characterized by the absence or marked paucity of histologic clues for the diagnosis of neuroblastoma.
  • Further study of this variant of neuroblastoma with more patients is required to determine optimal therapy, more accurately predict outcome, and to ascertain if ALCNB are a distinct biologic group of neuroblastomas.
  • [MeSH-major] Abdominal Neoplasms / pathology. Neuroblastoma / pathology. Pelvic Neoplasms / pathology. Thoracic Neoplasms / pathology

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  • (PMID = 18397155.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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66. Boutros J, Bond M, Beaudry P, Blair GK, Skarsgard ED: Case selection in minimally invasive surgical treatment of neuroblastoma. Pediatr Surg Int; 2008 Oct;24(10):1177-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case selection in minimally invasive surgical treatment of neuroblastoma.
  • PURPOSE: The experience with minimally invasive surgery (MIS) in the treatment of neuroblastoma (NB) is anecdotal.
  • Six of the eight (75%) tumors were adrenal in origin and the remainder were located in the posterior mediastinum.
  • Distribution by International Neuroblastoma Staging System (INSS) stage was: stage 1 (3), stage 2 (2), and stage 4 (3).
  • [MeSH-major] Minimally Invasive Surgical Procedures. Neuroblastoma / surgery. Patient Selection
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / surgery. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Male. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / surgery. Neoadjuvant Therapy. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery. Retrospective Studies

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  • (PMID = 18716783.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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67. Iwakura H, Ariyasu H, Kanamoto N, Hosoda K, Nakao K, Kangawa K, Akamizu T: Establishment of a novel neuroblastoma mouse model. Int J Oncol; 2008 Dec;33(6):1195-9
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  • [Title] Establishment of a novel neuroblastoma mouse model.
  • Neuroblastoma is the most common childhood cancer, which arises from sympathetic neural precursors.
  • Because the prognosis of advanced neuroblastoma is known to be poor, developments of new anti-cancer drugs are desperately needed.
  • For screening of therapeutic drugs for neuroblastoma, genetically engineered animal models would be useful.
  • In an attempt to obtain transgenic mice carrying simian virus 40 T-antigen gene under control of tetracycline responsive elements with cytomegalovirus promoter, we found one line of mice exhibiting bilateral adrenal tumors by leakage expression of T-antigen in adrenal gland.
  • These adrenal tumors contained small round tumor cells with increased N/C ratio, showing chromogranin A and neuron specific enolase-like immunoreactivity.
  • These findings indicated that the adrenal tumor was a neuroblastoma.
  • This mouse model would be a useful tool for development of chemotherapeutic drugs and understanding the etiology of neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Experimental / pathology. Neuroblastoma / pathology


68. Kumar M, Gupta P, Chaubey A: The thyroid: an extremely rare primary site of neuroblastoma. Hum Pathol; 2006 Oct;37(10):1357-60
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  • [Title] The thyroid: an extremely rare primary site of neuroblastoma.
  • Neuroblastoma (NB) is uncommon in the adolescent age group.
  • It is located at any site containing sympathetic neural tissue, with retroperitoneal and adrenal lesions being the most common.
  • The differential diagnosis was primitive neuroectodermal tumor.
  • [MeSH-major] Neuroblastoma / secondary. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Neuroectodermal Tumors, Primitive / diagnosis. Phosphopyruvate Hydratase / analysis. Vanilmandelic Acid / urine

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  • (PMID = 16949905.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 55-10-7 / Vanilmandelic Acid; EC 4.2.1.11 / Phosphopyruvate Hydratase
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69. De Preter K, De Brouwer S, Van Maerken T, Pattyn F, Schramm A, Eggert A, Vandesompele J, Speleman F: Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compounds. Clin Cancer Res; 2009 Jun 1;15(11):3690-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compounds.
  • PURPOSE: Neuroblastoma is a heterogeneous childhood tumor with poor survival outcome for the aggressive type despite intensive multimodal therapies.
  • In this study, we aimed to identify new treatment options for neuroblastoma based on integrative genomic analysis.
  • We have used this strategy in the search for new therapeutic molecules for neuroblastoma based on data of an integrative meta-analysis of gene copy number and expression profiles from 146 primary neuroblastoma tumors and normal fetal neuroblasts.
  • RESULTS: In a first step, a 132-gene classifier was established that discriminates three major genomic neuroblastoma subgroups, reflecting inherent differences in gene expression between these subgroups.
  • Subsequently, we screened the Connectivity Map database using gene lists generated by comparing expression profiles of fetal adrenal neuroblasts and the genomic subgroups of neuroblastomas.
  • CONCLUSIONS: This proof-of-principle study indicates that an integrative genomic meta-analysis approach with inclusion of neuroblast data enables the identification of promising compounds for treatment of children with neuroblastoma.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Gene Expression Profiling / statistics & numerical data. Meta-Analysis as Topic. Neuroblastoma / genetics

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  • (PMID = 19435837.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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70. Gao XN, Tang SQ, Lin J: [Clinical features and prognosis of advanced neuroblastoma in children]. Zhongguo Dang Dai Er Ke Za Zhi; 2007 Aug;9(4):351-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical features and prognosis of advanced neuroblastoma in children].
  • OBJECTIVE: To investigate the clinical features, treatment modalities and the prognosis of advanced neuroblastoma in children.
  • METHODS: The medical records of 63 children with stage III or IV neuroblastoma from January 1996 to December 2005 were retrospectively reviewed.
  • RESULTS: Of the 63 patients with advanced neuroblastoma, the male/female ratio was 2.7:1 and the median age at diagnosis was 4 years old.
  • Primary tumor sites were adrenal (38%), retroperitoneal (35%), mediastinal (17%), pelvic (6%) and cervical (2%).
  • The sites of metastasis at diagnosis included local (41%) and (or) distant (37%) lymph nodes, bone marrow (60%), bone (46%) and liver (16%).
  • Statistical analysis demonstrated that unfavorable survival prognostic factors were the following: age > 1 year at diagnosis (P < 0.05); serum neuro-specific enolase > 100 mg/L (P < 0.05); serum lactic dehydrogenase > 1500 U/L (P < 0.01); serum ferritin >150 mg/L (P < 0.05).
  • CONCLUSIONS: Neuroblastoma with advanced stages often presents with various clinical manifestations and has a poor prognosis.
  • It is beneficial to improve the prognosis of neuroblastoma through an early diagnosis and a comprehensive therapy including total resection of the primary tumor, autologous peripheral blood stem cell transplantation and intensive chemotherapy.
  • [MeSH-major] Neuroblastoma / mortality

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  • (PMID = 17706038.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Fung MM, Viveros OH, O'Connor DT: Diseases of the adrenal medulla. Acta Physiol (Oxf); 2008 Feb;192(2):325-35
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  • [Title] Diseases of the adrenal medulla.
  • The adrenal glands are vital in the organism's response to environmental stress.
  • Pathology within the adrenal medulla and the autonomic nervous system is primarily because of neoplasms.
  • The most common tumour, called phaeochromocytoma when located in the adrenal medulla, originates from chromaffin cells and excretes catecholamines, but may be referred to as secreting paragangliomas when found in extra-adrenal chromaffin cells.

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  • (PMID = 18021328.001).
  • [ISSN] 1748-1716
  • [Journal-full-title] Acta physiologica (Oxford, England)
  • [ISO-abbreviation] Acta Physiol (Oxf)
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL058120-090004; United States / NIDDK NIH HHS / DK / DK060702-05; United States / NHLBI NIH HHS / HL / HL058120-099006; United States / NIDDK NIH HHS / DK / R01 DK060702-05; United States / NHLBI NIH HHS / HL / HL058120-09; United States / NHLBI NIH HHS / HL / P01 HL058120-09; United States / NHLBI NIH HHS / HL / P01 HL058120-099006; United States / NIDDK NIH HHS / DK / R01 DK060702; United States / NHLBI NIH HHS / HL / P01 HL058120; United States / NHLBI NIH HHS / HL / P01 HL058120-090004
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Catecholamines
  • [Number-of-references] 33
  • [Other-IDs] NLM/ NIHMS57919; NLM/ PMC2576282
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72. Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T: Concordance for neuroblastoma in monozygotic twins: case report and review of the literature. J Pediatr Surg; 2010 Dec;45(12):2312-6
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  • [Title] Concordance for neuroblastoma in monozygotic twins: case report and review of the literature.
  • Resection of an adrenal tumor and a liver tumor biopsy were performed.
  • Screening by abdominal ultrasonography showed multiple masses in the liver but no adrenal mass.
  • All primary tumor and liver tumor specimens from twin 2 and the liver tumor of twin 1 had the same histologic classification of neuroblastoma and nearly identical genetic aberrations, including a chromosome gain or loss using array-comparative genomic hybridization.
  • In the literature, 9 pairs of concordant twin neuroblastomas, including the current twin, have been presented; and the clinical findings of 5 twin pairs may represent placental metastases from one twin with congenital neuroblastoma to the other twin.
  • This study is the first report presenting the possibility of twin-to-twin metastasis in monozygotic twins with neuroblastoma based on an analysis of the clinical features and genetic aberrations.
  • [MeSH-major] Adrenal Gland Neoplasms / embryology. Diseases in Twins / embryology. Fetofetal Transfusion. Liver Neoplasms / secondary. Neuroblastoma / embryology. Neuroblastoma / secondary. Placenta / pathology. Twins, Monozygotic

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21129536.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 35MRW7B4AD / 3-Iodobenzylguanidine; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide
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73. Sultan I, Ghandour K, Al-Jumaily U, Hashem S, Rodriguez-Galindo C: Local control of the primary tumour in metastatic neuroblastoma. Eur J Cancer; 2009 Jul;45(10):1728-32
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  • [Title] Local control of the primary tumour in metastatic neuroblastoma.
  • The previous studies have stressed on the importance of loco-regional control in the management of high-risk neuroblastoma.
  • We searched the Surveillance, Epidemiology and End-Results (SEER) database for patients older than 2years with metastatic neuroblastoma who were diagnosed from 1998 to 2005.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Neuroblastoma / secondary. Neuroblastoma / surgery

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  • (PMID = 19447607.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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74. Chan EL, Harris RE, Emery KH, Gelfand MJ, Collins MH, Gruppo RA: Favorable histology, MYCN-amplified 4S neonatal neuroblastoma. Pediatr Blood Cancer; 2007 Apr;48(4):479-82
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  • [Title] Favorable histology, MYCN-amplified 4S neonatal neuroblastoma.
  • We report a neonate with 4S neuroblastoma and MYCN amplification, but favorable Shimada histology, successfully treated with chemotherapy and 13-cis-retinoic acid without stem cell transplantation.
  • MYCN amplification in neuroblastoma is usually associated with unfavorable Shimada histology; the presence of these features in infants with 4S disease confers a poor prognosis.
  • A small number of infants with 4S neuroblastoma and MYCN amplification have favorable Shimada histology.

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  • (PMID = 16333837.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD043005; United States / NICHD NIH HHS / HD / T32 HD43005-01
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; EH28UP18IF / Isotretinoin
  • [Number-of-references] 21
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75. Sugito K, Kusafuka T, Hoshino M, Inoue M, Goto H, Ikeda T, Hagiwara N, Koshinaga T, Fukuzawa M, Nakamura M, Shichino H, Chin M, Mugishima H, Saito T, Tanaka Y: Intraoperative radiation therapy for advanced neuroblastoma: the problem of securing the IORT field. Pediatr Surg Int; 2007 Dec;23(12):1203-7
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  • [Title] Intraoperative radiation therapy for advanced neuroblastoma: the problem of securing the IORT field.
  • The purpose of this study is to evaluate the efficacy of intraoperative radiation therapy (IORT) and the problem of securing the IORT field in advanced pediatric neuroblastoma.
  • Between 1996 and 2005, 12 children received IORT for advanced pediatric neuroblastoma patients.
  • Nine patients were alive 17-120 (mean 48 months) after diagnosis.
  • For advanced neuroblastoma patients, IORT produced excellent local control after surgery.
  • [MeSH-major] Adrenal Gland Neoplasms / radiotherapy. Adrenalectomy / methods. Intraoperative Care / methods. Laparotomy / methods. Neuroblastoma / radiotherapy. Retroperitoneal Neoplasms / radiotherapy
  • [MeSH-minor] Biopsy. Child. Child, Preschool. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17968560.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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76. Krug P, Schleiermacher G, Michon J, Valteau-Couanet D, Brisse H, Peuchmaur M, Sarnacki S, Martelli H, Desguerre I, Tardieu M: Opsoclonus-myoclonus in children associated or not with neuroblastoma. Eur J Paediatr Neurol; 2010 Sep;14(5):400-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Opsoclonus-myoclonus in children associated or not with neuroblastoma.
  • OBJECTIVE: To compare the clinical data at diagnosis, treatment and neurological outcome in 34 children with opsoclonus-myoclonus syndrome (OMS) associated with a detected neuroblastoma or not.
  • RESULTS: Twenty-two patients had OMS associated with a neuroblastoma.
  • Twelve children had OMS without a detected neuroblastoma.
  • In the 27 OMS patients with or without neuroblastoma whose follow up was greater than two years, the neurological outcome was evaluated: 59.3% had neurological sequelae, including motor, praxic and/or language sequelae (n=9), persistent ataxia (n=6) and moderate motor deficit (n=3).
  • CONCLUSION: Our retrospective study provides further evidence that OMS with or without a detected neuroblastoma is the same disease, whose major challenges are the neurological sequelae.
  • An international collaboration is required to improve the knowledge about OMS, the treatment and the outcome in this rare disorder.
  • [MeSH-major] Neuroblastoma / complications. Opsoclonus-Myoclonus Syndrome / physiopathology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Child, Preschool. Female. Humans. Infant. Male. Retrospective Studies

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  • [Copyright] Copyright (c) 2009 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20110181.001).
  • [ISSN] 1532-2130
  • [Journal-full-title] European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
  • [ISO-abbreviation] Eur. J. Paediatr. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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77. Longo L, Borghini S, Schena F, Parodi S, Albino D, Bachetti T, Da Prato L, Truini M, Gambini C, Tonini GP, Ceccherini I, Perri P: PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. Int J Oncol; 2008 Nov;33(5):985-91
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  • [Title] PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma.
  • The detection of PHOX2B mutations in a small proportion of patients affected with either familial or sporadic neuroblastoma (NB), has arisen interest on the possible pathogenic role of this gene in the disease determination.
  • In this light, we have carried out a quantitative expression analysis of PHOX2B and its paralogue PHOX2A on a panel of NB cell lines and NB tumour samples to identify a possible differential expression between NB cells and their normal counterpart (adrenal medulla cells).
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Homeodomain Proteins / genetics. Neuroblastoma / genetics. Transcription Factors / genetics
  • [MeSH-minor] Adrenal Medulla / metabolism. Cell Line, Tumor. DNA Mutational Analysis. Humans. Pedigree. Up-Regulation

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  • (PMID = 18949361.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / NBPhox protein; 0 / PHOX2A protein, human; 0 / Transcription Factors
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78. Kunieda E, Hirobe S, Kaneko T, Nagaoka T, Kamagata S, Nishimura G: Patterns of local recurrence after intraoperative radiotherapy for advanced neuroblastoma. Jpn J Clin Oncol; 2008 Aug;38(8):562-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patterns of local recurrence after intraoperative radiotherapy for advanced neuroblastoma.
  • OBJECTIVE: The purpose of this study was to retrospectively evaluate local recurrence patterns after intraoperative radiation therapy (IORT) combined with total or subtotal resection and intensive chemotherapy for advanced neuroblastoma.
  • METHODS: The outcomes of 27 patients (14 boys and 13 girls) with advanced-stage neuroblastoma who received IORT as part of multimodality therapy between November 1988 and December 2006 were reviewed in order to evaluate the impact of IORT.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adrenal Gland Neoplasms / radiotherapy. Neoplasm Recurrence, Local / diagnosis. Neuroblastoma / radiotherapy. Retroperitoneal Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Infant. Intraoperative Period. Magnetic Resonance Imaging. Male. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18667476.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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79. El-Maghraby T: 131I-MIBG in the diagnosis of primary and metastatic neuroblastoma. Gulf J Oncolog; 2007 Jul;(2):33-41
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  • [Title] 131I-MIBG in the diagnosis of primary and metastatic neuroblastoma.
  • OBJECTIVE: Neuroblastoma is the third most common malignancy of childhood.
  • 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging.
  • The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease.
  • METHODS: Twenty six patients provisionally diagnosed by clinical and imaging criteria to have neuroblastoma were included.
  • On histopathologic verification 5 of these 26 patients were rediagnosed as non-neuroblastoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Iodine Radioisotopes. Neuroblastoma / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radionuclide imaging. Bone Marrow Neoplasms / radionuclide imaging. Bone Marrow Neoplasms / secondary. Brain Neoplasms / radionuclide imaging. Brain Neoplasms / secondary. Child. Child, Preschool. Female. Humans. Infant. Liver Neoplasms / radionuclide imaging. Liver Neoplasms / secondary. Male. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / radionuclide imaging. Neoplasm Staging. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / radionuclide imaging. Spinal Neoplasms / pathology. Spinal Neoplasms / radionuclide imaging. Technetium Tc 99m Medronate

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  • (PMID = 20084722.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Kuwait
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine; X89XV46R07 / Technetium Tc 99m Medronate
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80. Hill G, Castellino S, Williams D: Cardiac myxoma after treatment for childhood neuroblastoma. Pediatr Cardiol; 2009 Apr;30(3):340-2
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  • [Title] Cardiac myxoma after treatment for childhood neuroblastoma.
  • An asymptomatic 13 year old with a history of neuroblastoma treated with chemotherapy, radiation therapy, and autologous bone marrow transplant was found to have a cardiac mass on screening echocardiogram.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Heart Neoplasms / etiology. Myxoma / etiology. Neuroblastoma / therapy
  • [MeSH-minor] Adolescent. Cardiac Surgical Procedures. Diagnosis, Differential. Echocardiography. Follow-Up Studies. Humans. Male. Risk Factors. Tomography, X-Ray Computed


81. Burke MJ, Cohn SL: Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma. Pediatr Blood Cancer; 2008 Mar;50(3):679-80
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  • [Title] Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma.
  • Opsoclonus-myoclonus syndrome (OMS) is a rare paraneoplastic syndrome that occurs in 2%-3% of patients with neuroblastoma.
  • We report our experience with Rituximab in a patient with neuroblastoma and OMS.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Antibodies, Monoclonal / therapeutic use. Ganglioneuroblastoma / complications. Immunotherapy. Opsoclonus-Myoclonus Syndrome / etiology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Child Behavior Disorders / etiology. Child, Preschool. Combined Modality Therapy. Diagnostic Errors. Humans. Immunoglobulins, Intravenous / therapeutic use. Immunosuppressive Agents / therapeutic use. Learning Disorders / etiology. Male. Psychomotor Disorders / etiology. Recurrence. Rituximab

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 16900484.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunoglobulins, Intravenous; 0 / Immunosuppressive Agents; 4F4X42SYQ6 / Rituximab
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82. Sano H, Gonzalez-Gomez I, Wu SQ, Armenian SH, Jubran RF, Shimada H: A case of composite neuroblastoma composed of histologically and biologically distinct clones. Pediatr Dev Pathol; 2007 May-Jun;10(3):229-32
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  • [Title] A case of composite neuroblastoma composed of histologically and biologically distinct clones.
  • We report a case of a 12-month-old girl with stage 3 neuroblastoma composed of 2 distinct clones in the adrenal primary tumor.
  • One clone showed neuroblastoma, poorly differentiated subtype with a low mitosis-karyorrhexis index (favorable histology), and the other was neuroblastoma, poorly differentiated subtype with a high mitosis-karyorrhexis index (unfavorable histology), according to the International Neuroblastoma Pathology Classification.
  • Lymph nodes from ipsilateral and contralateral sides contained metastatic neuroblastoma of the latter clone.
  • To our knowledge, however, this is the 1st case report of composite tumor with biologically favorable and unfavorable clones in the Neuroblastoma (Schwannian stroma-poor) category.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neuroblastoma / pathology
  • [MeSH-minor] Clone Cells. Female. Ferritins / blood. Homovanillic Acid / urine. Humans. In Situ Hybridization, Fluorescence. Infant. L-Lactate Dehydrogenase / blood. Neoplasm Staging. Nuclear Proteins / metabolism. Oncogene Proteins / metabolism. Treatment Outcome. Vanilmandelic Acid / urine

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  • (PMID = 17535087.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 55-10-7 / Vanilmandelic Acid; 9007-73-2 / Ferritins; EC 1.1.1.27 / L-Lactate Dehydrogenase; X77S6GMS36 / Homovanillic Acid
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83. Ertle F, Behnisch W, Al Mulla NA, Bessisso M, Rating D, Mechtersheimer G, Hero B, Kulozik AE: Treatment of neuroblastoma-related opsoclonus-myoclonus-ataxia syndrome with high-dose dexamethasone pulses. Pediatr Blood Cancer; 2008 Mar;50(3):683-7
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  • [Title] Treatment of neuroblastoma-related opsoclonus-myoclonus-ataxia syndrome with high-dose dexamethasone pulses.
  • Opsoclonus-myoclonus-ataxia-syndrome (OMS) represents a rare neuroblastoma-associated paraneoplastic syndrome that commonly results in neurologic deficits despite tumor resection and immunosuppressive therapy.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Dexamethasone / therapeutic use. Immunosuppressive Agents / therapeutic use. Neuroblastoma / complications. Opsoclonus-Myoclonus Syndrome / drug therapy


84. Moon SB, Park KW, Jung SE, Youn WJ: Neuroblastoma: treatment outcome after incomplete resection of primary tumors. Pediatr Surg Int; 2009 Sep;25(9):789-93
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  • [Title] Neuroblastoma: treatment outcome after incomplete resection of primary tumors.
  • PURPOSE: For International Neuroblastoma Staging System (INSS) stages III or IV neuroblastoma (intermediate or high risk), complete excision of the primary tumor is not always feasible.
  • [MeSH-major] Neuroblastoma / mortality. Neuroblastoma / therapy
  • [MeSH-minor] Adrenal Gland Neoplasms / mortality. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / therapy. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Dermatologic Agents / therapeutic use. Female. Follow-Up Studies. Genes, myc. Humans. Infant. Interleukin-2 / therapeutic use. Isotretinoin / therapeutic use. Male. Mediastinal Neoplasms / mortality. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / therapy. Neoplasm, Residual. Pelvic Neoplasms / mortality. Pelvic Neoplasms / pathology. Pelvic Neoplasms / therapy. Peripheral Blood Stem Cell Transplantation. Radiotherapy, Adjuvant. Retroperitoneal Neoplasms / mortality. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / therapy. Retrospective Studies

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  • (PMID = 19629500.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Dermatologic Agents; 0 / Interleukin-2; EH28UP18IF / Isotretinoin
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85. Onitake Y, Hiyama E, Kamei N, Yamaoka H, Sueda T, Hiyama K: Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres. J Pediatr Surg; 2009 Dec;44(12):2258-66
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  • [Title] Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres.
  • PURPOSE: Neuroblastoma (NBL) shows remarkable biologic heterogeneity, resulting in favorable or unfavorable prognoses.
  • [MeSH-major] Neuroblastoma / genetics. Telomere / ultrastructure. Telomere-Binding Proteins / metabolism
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / genetics. Adrenal Gland Neoplasms / metabolism. Adrenal Gland Neoplasms / mortality. Blotting, Southern / statistics & numerical data. Child. Child, Preschool. Disease-Free Survival. Drug Resistance, Neoplasm / genetics. Flow Cytometry / statistics & numerical data. Humans. Mass Screening / statistics & numerical data. Mediastinal Neoplasms / genetics. Mediastinal Neoplasms / metabolism. Mediastinal Neoplasms / mortality. Ploidies. Prognosis. Retroperitoneal Neoplasms / genetics. Retroperitoneal Neoplasms / metabolism. Retroperitoneal Neoplasms / mortality. Survival Analysis. Tandem Repeat Sequences / genetics. Telomerase / genetics. Telomerase / metabolism

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  • (PMID = 20006006.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Telomere-Binding Proteins; EC 2.7.7.49 / Telomerase
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86. Wills H, Kast R, Stewart C, Rabah R, Pandya A, Poulik J, Auner G, Klein MD: Raman spectroscopy detects and distinguishes neuroblastoma and related tissues in fresh and (banked) frozen specimens. J Pediatr Surg; 2009 Feb;44(2):386-91
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  • [Title] Raman spectroscopy detects and distinguishes neuroblastoma and related tissues in fresh and (banked) frozen specimens.
  • METHODS: Fresh specimens of neuroblastoma and other pediatric neural crest tumors were analyzed with Raman spectroscopy.
  • RESULTS: We collected 1114 spectra (862 fresh and 252 frozen) from 62 tissue samples, including 8 normal adrenal glands, 29 neuroblastomas, 14 ganglioneuromas, 8 nerve sheath tumors, and 3 pheochromocytomas.
  • At the tissue level, frozen neuroblastoma, ganglioneuroma, nerve sheath tumor, and pheochromocytoma were distinguished from normal adrenal tissue with 100% sensitivity and specificity.
  • [MeSH-major] Cryopreservation. Neuroblastoma / pathology. Spectrum Analysis, Raman
  • [MeSH-minor] Child. Diagnosis, Differential. Humans

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  • (PMID = 19231540.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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87. Hsiao CC, Huang CC, Sheen JM, Tai MH, Chen CM, Huang LL, Chuang JH: Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Mod Pathol; 2005 May;18(5):656-62
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  • [Title] Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma.
  • Neuroblastoma is an extremely malignant solid tumor in children, characterized by spontaneous differentiation and regression.
  • An epidermal growth factor-like homeotic protein, delta-like (dlk), has been involved in differentiation of neuroblastoma cell lines, but is unknown in in vivo expression of neuroblastoma.
  • By using in situ hybridization and immunohistochemistry, dlk mRNA and protein expression were studied in formalin-fixed archival tissues from 10 patients with neuroblastoma, five with ganglioneuroblastoma, and five with ganglioneuroma.
  • Three adrenal tissues from children died of diseases other than adrenal tumors and one from an adult with pheochromocytoma were severed as normal and disease controls.
  • The results showed strong immunoreactive dlk staining in endothelial cells in neuroblastoma, ganglioneuroblastoma and ganglioneuroma.
  • Dlk was detectable in mature neuromatous stroma and gangliocytes of ganglioneuroma, but not in neuroblasts of neuroblastoma and ganglioneuroblastoma, neither in gangliocytes of ganglioneuroblastoma.
  • The findings indicated that there is differential expression of dlk gene and protein among neuroblastoma, ganglioneuroblastoma and ganglioneuroma.
  • The stronger expression of dlk in gangliocytes in ganglioneuroma, in contrast to weaker or no expression in gangliocytes in ganglioneuroblastoma and neuroblasts in neuroblastoma, suggests upregulation of dlk during differentiation of neuroblastoma into more benign form.
  • Furthermore, higher dlk protein expression in the tumor endothelium than in the endothelium of normal adrenal gland implies that dlk may regulate the endothelial function in neuroblastic tumors.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Epidermal Growth Factor / genetics. Epidermal Growth Factor / metabolism. Female. Ganglioneuroblastoma / genetics. Ganglioneuroblastoma / metabolism. Ganglioneuroblastoma / pathology. Ganglioneuroma / genetics. Ganglioneuroma / metabolism. Ganglioneuroma / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization. Infant. Infant, Newborn. Male. Neuroblastoma / genetics. Neuroblastoma / metabolism. Neuroblastoma / pathology. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 15605081.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / RNA, Messenger; 62229-50-9 / Epidermal Growth Factor
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88. van den Berg H, Caron HN: Paratesticular neuroblastoma: a case against metastatic disease? J Pediatr Hematol Oncol; 2007 Mar;29(3):187-9
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  • [Title] Paratesticular neuroblastoma: a case against metastatic disease?
  • Paratesticular lesions of neuroblastoma are in contrast to testicular infiltration extremely rare.
  • We present a 9-month-old boy with stage 4 neuroblastoma, in which an unsuspected scrotal localization was already present at birth.
  • The case illustrates that neuroblastoma is a multicentric tumor, originating in the adrenal area and paratesticular sympathic remnants.
  • [MeSH-major] Neuroblastoma. Testicular Neoplasms
  • [MeSH-minor] 3-Iodobenzylguanidine / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Follow-Up Studies. Humans. Infant. Male. Neoplasm Metastasis. Neoplasm Staging. Stem Cell Transplantation. Transplantation, Autologous. Treatment Outcome

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  • (PMID = 17356400.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 35MRW7B4AD / 3-Iodobenzylguanidine
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89. Paulino AC, Fowler BZ: Risk factors for scoliosis in children with neuroblastoma. Int J Radiat Oncol Biol Phys; 2005 Mar 1;61(3):865-9
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  • [Title] Risk factors for scoliosis in children with neuroblastoma.
  • PURPOSE: To determine the risk factors for scoliosis in children treated for neuroblastoma.
  • METHODS AND MATERIALS: From 1957 to 1997, 58 children with neuroblastoma were treated at one institution and have survived a minimum of 5 years.
  • There were 35 boys and 23 girls with a median age of 6 months (range, 2 weeks to 15 years) at initial diagnosis.
  • Primary site was located in the adrenal gland in 25 (43.1%), abdominal/nonadrenal in 16 (27.6%), thoracic in 12 (20.7%), cervical in 3 (5.3%), and pelvic region in 2 (3.5%).
  • The International Neuroblastoma Staging System (INSS) stage was Stage 1 in 10 (17.2%), Stage 2A in 7 (12.1%), Stage 2B in 5 (8.6%), Stage 3 in 22 (37.9%), Stage 4 in 4 (6.9%), and Stage 4S in 10 (17.2%).
  • Four had scoliosis ranging from 30 degrees to 66 degrees ; 3 of these patients required surgical intervention, whereas 1 had an underlying Duchenne muscular dystrophy which manifested itself 8 years after diagnosis of neuroblastoma.
  • Gender, age at diagnosis, INSS stage, primary site, and use of chemotherapy were not found to be significant.
  • CONCLUSIONS: Treatment-related factors, namely laminectomy and radiotherapy, were found to increase the risk of scoliosis in patients with neuroblastoma.
  • [MeSH-major] Neuroblastoma / radiotherapy. Scoliosis / etiology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Laminectomy / adverse effects. Male. Multivariate Analysis. Neoplasm Staging. Radiotherapy Dosage. Risk Factors

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  • (PMID = 15708267.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Fuchs D, Christofferson R, Stridsberg M, Lindhagen E, Azarbayjani F: Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments. J Transl Med; 2009;7:16
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  • [Title] Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments.
  • BACKGROUND: High-risk neuroblastoma has an overall five-year survival of less than 40%, indicating a need for new treatment strategies such as angiogenesis inhibition.
  • The aim of this study was primarily to characterize tumor spread in an orthotopic, metastatic model for aggressive, MYCN-amplified neuroblastoma and secondarily to study the effects of daily administration of the chemotherapeutic agent CHS 828 on tumor angiogenesis, tumor growth, and spread.
  • METHODS: MYCN-amplified human neuroblastoma cells (IMR-32, 2 x 10(6)) were injected into the left adrenal gland in SCID mice through a flank incision.
  • RESULTS: The orthotopic model resembled clinical neuroblastoma in respect to tumor site, growth and spread.
  • CONCLUSION: The metastatic animal model in this study resembled clinical neuroblastoma and is therefore clinically relevant for examining new treatment strategies for this malignancy.
  • Our results indicate that daily scheduling of CHS 828 may be beneficial in treating patients with high-risk neuroblastoma.
  • [MeSH-major] Cell Compartmentation. Endothelial Cells / pathology. Neuroblastoma / pathology. Neuroblastoma / therapy
  • [MeSH-minor] Animals. Autopsy. Calgranulin A / blood. Cell Line, Tumor. Cyanides / toxicity. Fibroblasts / drug effects. Guanidines / toxicity. Humans. Liver Neoplasms / secondary. Mice. Mice, SCID. Neoplasm Metastasis. Neovascularization, Pathologic / metabolism. Remission Induction. Risk Factors. Xenograft Model Antitumor Assays

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  • (PMID = 19284605.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calgranulin A; 0 / Cyanides; 0 / Guanidines; 0 / N-(6-chlorophenoxyhexyl)-N''-cyano-N''-4-pyridylguanidine
  • [Other-IDs] NLM/ PMC2667491
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91. Nevo I, Sagi-Assif O, Edry Botzer L, Amar D, Maman S, Kariv N, Leider-Trejo LE, Savelyeva L, Schwab M, Yron I, Witz IP: Generation and characterization of novel local and metastatic human neuroblastoma variants. Neoplasia; 2008 Aug;10(8):816-27
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  • [Title] Generation and characterization of novel local and metastatic human neuroblastoma variants.
  • Neuroblastoma (NB) is the most commonly occurring solid tumor in children.
  • The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression.
  • Most NB patients with an advanced disease have massive bone marrow infiltration at diagnosis.
  • SH-SY5Y and MHH-NB-11 NB cells were inoculated orthotopically into the adrenal glands of athymic nude mice.
  • Neuroblastoma cells metastasizing to the lungs were isolated from mice bearing adrenal tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Disease Models, Animal. Lung Neoplasms / secondary. Neoplasms, Experimental / secondary. Neuroblastoma / secondary

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  • (PMID = 18683320.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 80168379AG / Doxorubicin; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; J06Y7MXW4D / Deferoxamine
  • [Other-IDs] NLM/ PMC2504768
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92. Zhang N, Lin LK: Presumed primary orbital neuroblastoma in a 20-month-old female. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):383-5
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  • [Title] Presumed primary orbital neuroblastoma in a 20-month-old female.
  • Neuroblastoma is the most common malignant disease of childhood, and it often arises from either the adrenal gland or along the sympathetic chain.
  • The authors report a case of a 20-month-old female with a presumed primary neuroblastoma of the orbit.
  • To the best of the authors' knowledge, primary orbital neuroblastoma has only been previously reported once in children, although it has been reported twice in adults.
  • [MeSH-major] Neuroblastoma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bone Marrow Transplantation. Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 20622692.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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93. Joseph JM, Gross N, Lassau N, Rouffiac V, Opolon P, Laudani L, Auderset K, Geay JF, Mühlethaler-Mottet A, Vassal G: In vivo echographic evidence of tumoral vascularization and microenvironment interactions in metastatic orthotopic human neuroblastoma xenografts. Int J Cancer; 2005 Mar 1;113(6):881-90
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  • [Title] In vivo echographic evidence of tumoral vascularization and microenvironment interactions in metastatic orthotopic human neuroblastoma xenografts.
  • Human neuroblastoma (NB) is the second most frequent solid tumor of childhood and represents a highly heterogeneous disease at clinical and biologic levels.
  • Results show that implantation of low numbers of NB cells directly into the adrenal gland of nude mice resulted in rapid and homogeneous tumor growth without tumor morbidity.
  • Nude mice were shown to rapidly develop highly vascularized adrenal tumors that selectively metastasized to the liver and bone marrow.
  • In addition, the newly formed mouse vessels in orthotopic but not in heterotopic tumors, were found to express the highly angiogenic alphavbeta3 integrin marker, indicating the development of a truly malignant neovasculature in orthotopic conditions only.
  • [MeSH-major] Neovascularization, Pathologic / pathology. Neuroblastoma / blood supply. Neuroblastoma / pathology
  • [MeSH-minor] Animals. Cell Division. Cell Line, Tumor. Child. Genes, Reporter. Green Fluorescent Proteins / analysis. Green Fluorescent Proteins / genetics. Humans. Immunohistochemistry. Male. Mice. Mice, Inbred ICR. Mice, Nude. Mice, SCID. Microcirculation / pathology. Neoplasm Metastasis. Transfection. Transplantation, Heterologous

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  • [Copyright] (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15514941.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins
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94. Alcasabas P, Dettore A, Ozgönenel B, Bhambhani K, Ravindranath Y, Savaşan S: Vacuolated neuroblastoma cells mimicking FAB L(3) lymphoblasts in bone marrow aspirates. Pediatr Blood Cancer; 2007 Feb;48(2):227-9
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  • [Title] Vacuolated neuroblastoma cells mimicking FAB L(3) lymphoblasts in bone marrow aspirates.
  • Abundant cytoplasmic vacuolation of neuroblasts has been noted on bone marrow aspirate (BMA) smears of two patients with metastatic neuroblastoma.
  • Cytoplasmic vacuolations of neuroblasts may be a feature of metastatic neuroblastoma cells in BMA smears.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Bone Marrow Cells / pathology. Neuroblastoma / pathology
  • [MeSH-minor] Child, Preschool. Female. Flow Cytometry. Humans. Male. Neoplasm Metastasis / pathology. Phosphopyruvate Hydratase / analysis. Vacuoles / pathology

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  • (PMID = 16425244.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 4.2.1.11 / Phosphopyruvate Hydratase
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95. Nzegwu MA, Aghaji A: Neuroblastoma occurring in a 38-year old Nigerian man: a rare finding. Rare Tumors; 2009;1(1):e15

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  • [Title] Neuroblastoma occurring in a 38-year old Nigerian man: a rare finding.
  • Neuroblastoma (NB) is a common malignancy in children, but rarely occurs in adults.
  • In adults, abdomen/retroperitoneum are the primary sites and in children the adrenal gland.
  • This study emphasizes the need for a standard treatment regime for adult onset neuroblastoma and its recognition as a possible differential in intra-abdominal mass in adults.

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  • (PMID = 21139886.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994447
  • [Keywords] NOTNLM ; adult. / neuroblastoma
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96. Comstock JM, Willmore-Payne C, Holden JA, Coffin CM: Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma. Am J Clin Pathol; 2009 Jul;132(1):69-73
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  • [Title] Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma.
  • Composite pheochromocytoma is a rare adrenal tumor composed of ordinary pheochromocytoma and other components, most frequently neuroblastic elements.
  • Little is known about its biologic potential, therefore creating a clinical dilemma on diagnosis.
  • This study investigates the clinical characteristics and N-myc amplification status of 4 cases of composite pheochromocytoma and compares them with selected cases of ordinary pheochromocytoma and neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neuroblastoma / pathology. Pheochromocytoma / pathology


97. Elimam NA, Atra AA, Fayea NY, Al-Asaad TG, Khattab TM, Al-Sulami GA, Felimban SK: Stage 4S neuroblastoma, a disseminated tumor with excellent outcome. Saudi Med J; 2006 Nov;27(11):1734-6
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  • [Title] Stage 4S neuroblastoma, a disseminated tumor with excellent outcome.
  • OBJECTIVE: To review the clinical features and outcome of all cases of stage 4S neuroblastoma treated at our center.
  • METHODS: We retrospectively reviewed the files of all patients (n=75) with neuroblastoma treated at King Abdul-Aziz Medical City, Jeddah, Kingdom of Saudi Arabia between 1986 and 2005.
  • We studied the clinical features and outcome of patients with stage 4S neuroblastoma.
  • RESULTS: Six patients (8%) were confirmed to have stage 4S neuroblastoma.
  • Three were boys with a median age at diagnosis of 4.5 months (range 28 days-11 months).
  • CONCLUSION: Stage 4S neuroblastoma is a special tumor that carries excellent prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms. Liver Neoplasms. Neuroblastoma
  • [MeSH-minor] Adrenal Glands / pathology. Age Factors. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Agents, Phytogenic / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Carboplatin / administration & dosage. Carboplatin / therapeutic use. Cyclophosphamide / administration & dosage. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Etoposide / administration & dosage. Etoposide / therapeutic use. Female. Follow-Up Studies. Hepatomegaly / diagnosis. Hepatomegaly / etiology. Humans. Infant. Infant, Newborn. Male. Neoplasm Regression, Spontaneous. Neoplasm Staging. Prognosis. Retrospective Studies. Saudi Arabia. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Neoplasms / secondary. Survival Analysis. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Vincristine / administration & dosage. Vincristine / therapeutic use

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  • (PMID = 17106552.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; CAV protocol
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98. Ribatti D, Poliani PL, Longo V, Mangieri D, Nico B, Vacca A: Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma. Histopathology; 2007 Apr;50(5):636-41
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  • [Title] Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma.
  • AIMS: Previous studies have shown that increased vascularity is associated with tumour progression in human neuroblastoma (NB).
  • [MeSH-major] Adrenal Gland Neoplasms / blood supply. Erythropoietin / metabolism. Neovascularization, Pathologic / metabolism. Neuroblastoma / blood supply. Receptors, Erythropoietin / metabolism. Spinal Neoplasms / blood supply
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Fluorescent Antibody Technique, Direct. Humans. Immunoenzyme Techniques. Microcirculation. Neoplasm Staging

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  • (PMID = 17394500.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Erythropoietin; 11096-26-7 / Erythropoietin
  • [Other-IDs] NLM/ PMC1890992
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99. Gutweiler JR, Yu DC, Kim HB, Kozakewich HP, Marcus KJ, Shamberger RC, Weldon CB: Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma. J Pediatr Surg; 2008 Dec;43(12):2297-300
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  • [Title] Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma.
  • Although there is no evidence for malignant degeneration, FNH can occur adjacent to a malignancy.
  • Here, the case of a 4-year-old boy with a hepatic mass and history of stage IV neuroblastoma is presented.
  • However, after left lateral segmentectomy, pathologic examination revealed a malignant tumor most consistent with small cell undifferentiated hepatoblastoma as well as 3 foci of FNH in the surrounding parenchyma.
  • [MeSH-major] Adrenal Gland Neoplasms. Focal Nodular Hyperplasia / etiology. Hepatoblastoma / diagnosis. Liver Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Neuroblastoma

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  • (PMID = 19040959.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 3F8 antibody; 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; NR7O1405Q9 / Mesna; Q20Q21Q62J / Cisplatin; Q41OR9510P / Melphalan; U3P01618RT / Fluorouracil; UM20QQM95Y / Ifosfamide
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100. von Allmen D, Grupp S, Diller L, Marcus K, Ecklund K, Meyer J, Shamberger RC: Aggressive surgical therapy and radiotherapy for patients with high-risk neuroblastoma treated with rapid sequence tandem transplant. J Pediatr Surg; 2005 Jun;40(6):936-41; discussion 941
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive surgical therapy and radiotherapy for patients with high-risk neuroblastoma treated with rapid sequence tandem transplant.
  • BACKGROUND/PURPOSE: The treatment approach for patients with high-risk neuroblastoma has been one of dose intensification chemotherapy and aggressive treatment of the primary tumor.
  • METHODS: Seventy-six patients with high-risk stage III/IV neuroblastoma were treated on a standard protocol incorporating aggressive surgical resection with or without local XRT followed by tandem high-dose chemotherapy and stem cell rescue.
  • CONCLUSION: Aggressive surgical treatment with local XRT and myeloablative chemotherapy with stem cell rescue provides excellent local control in high-risk neuroblastoma, although distant failures, particularly osseous, remain a problem.
  • [MeSH-major] Abdominal Neoplasms / surgery. Adrenal Gland Neoplasms / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / surgery. Head and Neck Neoplasms / surgery. Neuroblastoma / surgery
  • [MeSH-minor] Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Neoplasm Staging. Peripheral Blood Stem Cell Transplantation. Radiotherapy, Adjuvant. Remission Induction / methods. Transplantation, Autologous. Treatment Outcome. Whole-Body Irradiation






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