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6. Jiang H, Rao KS, Yee VC, Kraus JP: Characterization of four variant forms of human propionyl-CoA carboxylase expressed in Escherichia coli. J Biol Chem; 2005 Jul 29;280(30):27719-27
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  • Propionyl-CoA carboxylase (PCC) is a biotin-dependent mitochondrial enzyme that catalyzes the conversion of propionyl-CoA to D-methylmalonyl-CoA.
  • PCC consists of two heterologous subunits, alpha PCC and beta PCC, which are encoded by the nuclear PCCA and PCCB genes, respectively.
  • Deficiency of PCC results in a metabolic disorder, propionic acidemia, which is sufficiently severe to cause neonatal death.
  • We have purified three PCCs containing pathogenic mutations in the beta subunit (R165W, E168K, and R410W) and one PCCB polymorphism (A497V) to homogeneity to elucidate the potential structural and functional effects of these substitutions.
  • The three mutant PCCs had half the catalytic efficiency of wild-type PCC as judged by the kcat/Km ratios.
  • However, the variant PCCs were less thermostable than the wild-type.
  • Our biochemical data and the structural analysis using a beta PCC homology model indicate that the pathogenic nature of these mutations is more likely to be due to a lack of assembly rather than disruption of catalysis.
  • The strong favorable effect of the co-expressed chaperone proteins on PCC folding, assembly, and activity suggest that propionic acidemia may be amenable to chaperone therapy.

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  • (PMID = 15890657.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P01HD08315
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acyl Coenzyme A; 0 / Recombinant Proteins; 1264-45-5 / methylmalonyl-coenzyme A; 317-66-8 / propionyl-coenzyme A; 6SO6U10H04 / Biotin; EC 4.1.1.41 / Methylmalonyl-CoA Decarboxylase
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7. López-Jiménez E, Gómez-López G, Leandro-García LJ, Muñoz I, Schiavi F, Montero-Conde C, de Cubas AA, Ramires R, Landa I, Leskelä S, Maliszewska A, Inglada-Pérez L, de la Vega L, Rodríguez-Antona C, Letón R, Bernal C, de Campos JM, Diez-Tascón C, Fraga MF, Boullosa C, Pisano DG, Opocher G, Robledo M, Cascón A: Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas. Mol Endocrinol; 2010 Dec;24(12):2382-91
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  • [Title] Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas.
  • The six major genes involved in hereditary susceptibility for pheochromocytoma (PCC)/paraganglioma (PGL) (RET, VHL, NF1, SDHB, SDHC, and SDHD) have been recently integrated into the same neuronal apoptotic pathway where mutations in any of these genes lead to cell death.
  • The aim of the study was to decipher specific alterations associated with the different genetic classes of PCCs/PGLs.
  • Nevertheless, when we compared VHL tumors with SDHB cases, which often exhibit a malignant behavior, we found that HIF-1α target genes showed a predominant activation in the VHL PCCs.
  • These findings pave the way for more specific therapeutic approaches for malignant PCCs/PGLs management based on the patient's genetic alteration.
  • [MeSH-major] Cell Death / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics. Succinate Dehydrogenase / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / genetics. Adrenal Gland Neoplasms / metabolism. Adult. Aged. Basic Helix-Loop-Helix Transcription Factors / genetics. Basic Helix-Loop-Helix Transcription Factors / metabolism. Child. Dioxygenases / genetics. Dioxygenases / metabolism. Humans. Hypoxia-Inducible Factor 1, alpha Subunit / genetics. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Hypoxia-Inducible Factor-Proline Dioxygenases. Middle Aged. Neoplasms / genetics. Young Adult. von Hippel-Lindau Disease / genetics. von Hippel-Lindau Disease / metabolism

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  • (PMID = 20980436.001).
  • [ISSN] 1944-9917
  • [Journal-full-title] Molecular endocrinology (Baltimore, Md.)
  • [ISO-abbreviation] Mol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / endothelial PAS domain-containing protein 1; EC 1.13.11.- / Dioxygenases; EC 1.14.11.29 / EGLN3 protein, human; EC 1.14.11.29 / Hypoxia-Inducible Factor-Proline Dioxygenases; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.3.2.27 / Von Hippel-Lindau Tumor Suppressor Protein; EC 6.3.2.- / VHL protein, human
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8. Meredith LS, Eisenman DP, Green BL, Basurto-Dávila R, Cassells A, Tobin J: System factors affect the recognition and management of posttraumatic stress disorder by primary care clinicians. Med Care; 2009 Jun;47(6):686-94
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  • [Title] System factors affect the recognition and management of posttraumatic stress disorder by primary care clinicians.
  • BACKGROUND: Posttraumatic stress disorder (PTSD) is common with an estimated prevalence of 8% in the general population and up to 17% in primary care patients.
  • Yet, little is known about what determines primary care clinician's (PCC's) provision of PTSD care.
  • OBJECTIVE: To describe PCC's reported recognition and management of PTSD and identify how system factors affect the likelihood of performing clinical actions with regard to patients with PTSD or "PTSD treatment proclivity."
  • DESIGN: Linked cross-sectional surveys of medical directors and PCCs.
  • PARTICIPANTS: Forty-six medical directors and 154 PCCs in community health centers (CHCs) within a practice-based research network in New York and New Jersey.
  • MEASUREMENTS: Two system factors (degree of integration between primary care and mental health services, and existence of linkages with other community, social, and legal services) as reported by medical directors, and PCC reports of self-confidence, perceived barriers, and PTSD treatment proclivity.
  • RESULTS: Surveys from 47 (of 58) medical directors (81% response rate) and 154 PCCs (86% response rate).
  • PCCs from CHCs with better mental health integration reported greater confidence, fewer barriers, and higher PTSD treatment proclivity (all P < 0.05).
  • The PCCs in CHCs with better community linkages reported greater confidence, fewer barriers, higher PTSD treatment proclivity, and lower proclivity to refer patients to mental health specialists or to use a "watch and wait" approach (all P < 0.05).
  • CONCLUSIONS: System factors play an important role in PCC PTSD management.
  • Interventions are needed that restructure primary care practices by making mental health services more integrated and community linkages stronger.

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  • (PMID = 19433999.001).
  • [ISSN] 1537-1948
  • [Journal-full-title] Medical care
  • [ISO-abbreviation] Med Care
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / MH070683-01A1; United States / NIMH NIH HHS / MH / R34 MH070683; United States / NIMH NIH HHS / MH / R34 MH070683-01A1; United States / NIMH NIH HHS / MH / R34MH070683
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS114528; NLM/ PMC2762995
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9. Fariña Pérez LA: [Laparoscopic adrenalectomy]. Actas Urol Esp; 2006 May;30(5):510-2
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  • Laparoscopic extirpation of the suprarenal gland is considered the 'gold standard' of surgery for benign conditions, but its indication in suprarenal cancer is still controversial.
  • In this article, we review the pros and cons of the laparoscopic approach in the different disorders that affect the adrenal gland, pheochromocytoma, cancer, partial and bilateral adrenalectomy, etc.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
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  • (PMID = 16884103.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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10. Liu RN, Wang W, Ding Y, Xie WD, Ma C, Du LJ: A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida. J Asian Nat Prod Res; 2007 Apr-Aug;9(3-5):333-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida.
  • A new compound, kaempferol 3-O-(2''-O-galloylrutinoside) (1), was isolated from the white flower of Nymphaea candida, together with nine known flavonol glycosides, kaempferol (2), kaempferol 3-O-beta-D-glucopyranoside (3), kaempferol 3-O-alpha-l-rhamnopyranoside (4), kaempferol 3-O-alpha-l-rhamnopyranosylglucopyranoside (5), kaempferol 7-O-beta-D-glucopyranoside 3-(O-alpha-l-rhamnopyranosylglucopyranoside) (6), quercetin (7), quercetin 3-O-beta-D-xylopyranoside (8), myricetin (9), myricetin 3'-O-beta-D-xylopyranoside (10).
  • Compounds 1-7 and 9 exhibited moderate to significant antioxidant activities, which were evaluated by measurement of low-density lipoprotein (LDL) and malondialdehyde (MDA) levels in vitro.
  • Compounds 1, 3, 4, 6 and 9 exhibited promising neuroprotective effects on ischemic injury model of cultured rat cortical neurons treated with sodium dithionite in glucose-free medium.
  • Furthermore, compounds 1, 5, and 9 had distinct cytotoxicity to adrenal gland pheochromocytoma, PC12 cells, being treated by the same way.

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  • (PMID = 17613618.001).
  • [ISSN] 1028-6020
  • [Journal-full-title] Journal of Asian natural products research
  • [ISO-abbreviation] J Asian Nat Prod Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Antioxidants; 0 / Disaccharides; 0 / Flavonols; 0 / Glycosides; 0 / Kaempferols; 0 / Neuroprotective Agents; 0 / kaempferol 3-O-(2''-O-galloylrutinoside)
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11. Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y: Radiation dose estimation using preclinical imaging with I124-metaiodobenzylguanidine (MIBG) PET. Med Phys; 2010 Sep;37(9):4861-4867

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  • PURPOSE: A pretherapyI124-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT) provides a potential method to estimate radiation dose to normal organs, as well as tumors prior to I131-MIBG treatment of neuroblastoma or pheochromocytoma.

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  • [Copyright] © 2010 American Association of Physicists in Medicine.
  • (PMID = 28524557.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Anatomy / Cancer / Computed tomography / Dosimetry / Heart / Liver / Medical imaging / PET / Positron emission tomography / Positron emission tomography (PET) / Radioactivity / Registration / Tissues / dosimetry / image registration / iodine-124 / metaiodobenzylguanidine (MIBG) / neuroblastoma / positron emission tomography / tumours
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12. Jeck-Thole S, Wagner W: Betahistine : A Retrospective Synopsis of Safety Data. Drug Saf; 2006 Nov;29(11):1049-1059

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  • Betahistine is a structural analogue of histamine that is prescribed for the treatment of vestibular disorders such as Ménière's disease and the symptomatic treatment of vertigo.
  • Betahistine was reported to be involved in one anaphylactoid reaction and one case of Stevens-Johnson syndrome.
  • ADRs related to the nervous system predominantly reveal heterogeneous events that are not suggestive of a specific adverse reaction profile for betahistine.
  • A total of three cases of neoplasm have been reported.
  • An undiagnosed phaeochromocytoma was suspected.

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  • (PMID = 28357699.001).
  • [ISSN] 1179-1942
  • [Journal-full-title] Drug safety
  • [ISO-abbreviation] Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
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13. Maĭstrenko NA, Romashchenko PN, Priadko AS, Vedeneeva LF, Markin SM: [The diagnosis and treatment of chromaffinomas]. Vestn Khir Im I I Grek; 2005;164(4):31-40
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  • [Title] [The diagnosis and treatment of chromaffinomas].
  • The results of examinations and surgical treatment of 117 patients with chromaffin tumors are shown: one-sided localization in the adrenal in 88% of the patients, bilateral localization in 4.3%, and extraadrenal in 7.7%.
  • An analysis of the possibilities of the laboratory-instrumental diagnosis of chromaffinomas has shown that the method should be used in case of valid need.
  • The absence of changes to the level of catecholamines and their metabolites in urine does not exclude the presence of chromaffinomas.
  • The optimal access for the ablation of chromaffinoma of the adrenal larger than 5 cm in diameter is thoracofrenotomy in the tenth intercostal space.
  • Endovideosurgical interventions in the adrenals can be used for the size of chromaffinoma less than 5 cm in diameter and with the absence of signs of malignisation and marked hemodynamic disorders.
  • The superior medial laparotomy is expedient for extraadrenal pheochromocytoma of the abdominal area and for bilateral localization in the adrenals.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / surgery. Pheochromocytoma / diagnosis

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
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  • (PMID = 16755734.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Catecholamines
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4. Lai EW, Rodriguez OC, Aventian M, Cromelin C, Fricke ST, Martiniova L, Lubensky IA, Lisanti MP, Picard KL, Powers JF, Tischler AS, Pacak K, Albanese C: ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice. Cell Cycle; 2007 Aug 1;6(15):1946-50
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  • [Title] ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice.
  • Pheochromocytoma (PCC) is a rare catecholamine-producing tumor that arises from the adrenal medulla and is often familial.
  • The genetic basis for familial PCC involves mutations of RET, VHL, SHDx or NF-1 in more than 20% of cases.
  • Additional genes may be important in pathogenesis of both familial and sporadic PCC.
  • ErbB-2/Her2/Neu is a growth factor receptor tyrosine kinase that is frequently overexpressed in tumors and there is clinical evidence suggesting that enhanced ErbB-2 growth factor receptor signaling may play a role in PCC.
  • In the present study, ectopic expression of an activated ErbB-2 transgene resulted in bilateral adrenal PCC.
  • Analyses of tumor samples and normal adrenal tissue revealed that levels of the Pten tumor suppressor protein were greatly reduced in PCCs, while levels of the cell cycle regulatory protein cyclin D1 were usually increased.
  • In addition, levels of phospo-AKT were increased in PCCs versus normal adrenal tissue.
  • Biochemical analyses established that PCC's were functionally active, producing abundant levels of the catecholamines, epinephrine and norepinephrine.
  • These data establish that increased ErbB-2 growth factor receptor signaling in the adrenal medulla can lead to PCC through combined influences on Pten, AKT andcyclin D1.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Adrenal Gland Neoplasms / pathology. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. Pheochromocytoma / metabolism. Pheochromocytoma / pathology. Receptor, ErbB-2 / metabolism


15. Lemeta S, Salmenkivi K, Pylkkänen L, Sainio M, Saarikoski ST, Arola J, Heikkilä P, Haglund C, Husgafvel-Pursiainen K, Böhling T: Frequent loss of heterozygosity at 6q in pheochromocytoma. Hum Pathol; 2006 Jun;37(6):749-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequent loss of heterozygosity at 6q in pheochromocytoma.
  • Multiple genetic alterations have been associated with pheochromocytoma (PCC).
  • Most PCCs are sporadic, but they also occur in inherited tumor syndromes, including von Hippel-Lindau disease.
  • Although the etiology of most inherited PCCs is well documented, little is known about the etiology of sporadic tumors.
  • Mutations of those genes that harbor germ-line mutations in familial cases cover only 10% to 15% of somatic mutations in sporadic PCCs.
  • A previous cytogenetic analysis indicated frequent loss of 6q in sporadic PCCs.
  • We therefore investigated in detail 18 PCCs using 22 microsatellite markers spanning 6q to search for the presence of allele deletions and identify specific regions likely to contain tumor suppressor genes involved in PCC.
  • Moreover, we sought to compare PCC with capillary hemangioblastoma, another von Hippel-Lindau disease-associated tumor that we previously found to harbor frequent loss of heterozygosity (LOH) at 6q.
  • Our study revealed a high frequency (13/18; 72%) of overall 6q LOH in PCCs.
  • Altogether, for all 6q23-25 markers, including the ZAC1-specific ones, LOH or allelic imbalance was observed in 50% (9/18) of the PCCs.
  • Similar to our findings for capillary hemangioblastomas, our data for the first time suggest that one or several tumor suppressor genes located at 6q, particularly at 6q23-24, may play a role in the tumorigenesis of PCCs.
  • [MeSH-major] Allelic Imbalance. Cell Cycle Proteins / genetics. Chromosomes, Human, Pair 6. Loss of Heterozygosity. Pheochromocytoma / genetics. Transcription Factors / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Aged. Alleles. DNA, Neoplasm / analysis. Female. Gene Deletion. Genetic Markers. Hemangioblastoma / genetics. Hemangioblastoma / pathology. Humans. Male. Microsatellite Repeats. Middle Aged. Tumor Burden

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  • (PMID = 16733217.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA, Neoplasm; 0 / Genetic Markers; 0 / PLAGL1 protein, human; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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21. McCreadie SR, McGregory ME: Experiences incorporating Tablet PCcs into clinical pharmacists' workflow. J Healthc Inf Manag; 2005;19(4):32-7

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  • [Title] Experiences incorporating Tablet PCcs into clinical pharmacists' workflow.
  • Tablet PCs are portable computers that combine the power of a laptop with an intuitive pendriven interface that have been heavily promoted for vertical industries such as healthcare.
  • The authors describe their experiences with tablet PCs used by clinical pharmacists in a large academic medical center.
  • Users reported increased efficiency on patient care rounds; they say they reduced or eliminated paper notes and shadow charts from their daily routine.

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  • (PMID = 16266030.001).
  • [ISSN] 1099-811X
  • [Journal-full-title] Journal of healthcare information management : JHIM
  • [ISO-abbreviation] J Healthc Inf Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Korpershoek E, Loonen AJ, Corvers S, van Nederveen FH, Jonkers J, Ma X, Ziel-van der Made A, Korsten H, Trapman J, Dinjens WN, de Krijger RR: Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma. J Pathol; 2009 Mar;217(4):597-604
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  • [Title] Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma.
  • Phaeochromocytomas (PCCs) are neuro-endocrine tumours of the adrenal medulla that are usually benign, but approximately 10% of patients develop metastases.
  • Malignant PCCs can only be diagnosed with certainty if metastases are present.
  • Here we describe adrenal tumours generated in a Pten conditional knock-out (KO) mouse model.
  • We characterized the molecular alterations in these tumours and compared them with human PCC.
  • Thirty-two of 41 (78%) male Psa-Cre;Pten-loxP/loxP mice presented adrenal tumours that were shown to be PCC by histology and by immunohistochemical staining for enzymes in the catecholamine biosynthetic pathway.
  • In 6 of 17 investigated mice, histological and immunohistochemical evidence was obtained for the presence of PCC lung metastases.
  • Array comparative genomic hybridization (CGH) analysis of the primary tumours showed loss of chromosomes 6 and 19, which are syntenic to human 3p and 11q.
  • The molecular aberrations in the mouse model corresponded to the alterations found in a subtype of human PCC, suggesting that the PCC of the Pten KO mice might be representative of human PCC.
  • The mouse model should allow further studies into the pathogenesis of human malignant PCCs and into therapeutic strategies for these tumours.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Disease Models, Animal. Lung Neoplasms / secondary. Neoplasm Proteins / genetics. PTEN Phosphohydrolase / genetics. Pheochromocytoma / secondary


23. Kupka S, Haack B, Zdichavsky M, Mlinar T, Kienzle C, Bock T, Kandolf R, Kroeber SM, Königsrainer A: Large proportion of low frequency microsatellite-instability and loss of heterozygosity in pheochromocytoma and endocrine tumors detected with an extended marker panel. J Cancer Res Clin Oncol; 2008 Apr;134(4):463-71
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  • [Title] Large proportion of low frequency microsatellite-instability and loss of heterozygosity in pheochromocytoma and endocrine tumors detected with an extended marker panel.
  • PURPOSE: Pheochromocytoma (PCC) is a usually benign tumor originated in the majority of patients from the adrenal medulla.
  • Regarding sporadic forms of PCC, mechanisms of pathogenesis are largely unknown.
  • Recently, microsatellite-instability (MSI) was discussed as genetic factor contributing to PCC development.
  • Since microsatellite markers used for MSI detection have only been recommended for colorectal carcinoma (CRC), we established an extended marker set for MSI detection in PCC.
  • METHODS: Twenty-two PCC patients were analyzed applying 11 microsatellite markers.
  • RESULTS: Microsatellite-instability was detected in 41% of PCCs.
  • Among the 23 patients with endocrine tumors, only three (one pancreatic endocrine tumor, one duodenal neuro-endocrine tumor, one hepatic metastasis of a primary tumor with unknown origin) demonstrated MSI.
  • CONCLUSIONS: The extended microsatellite panel is qualified to detect MSI in PCC.
  • PCCs are characterized by low frequency MSI pointing to failures in factors involved in DNA replication.
  • [MeSH-major] Endocrine Gland Neoplasms / genetics. Loss of Heterozygosity. Microsatellite Instability. Microsatellite Repeats. Pheochromocytoma / genetics

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  • (PMID = 17828419.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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24. Sarvet B, Gold J, Bostic JQ, Masek BJ, Prince JB, Jeffers-Terry M, Moore CF, Molbert B, Straus JH: Improving access to mental health care for children: the Massachusetts Child Psychiatry Access Project. Pediatrics; 2010 Dec;126(6):1191-200
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  • [Title] Improving access to mental health care for children: the Massachusetts Child Psychiatry Access Project.
  • BACKGROUND: Inadequate access to care for mentally ill children and their families is a persistent problem in the United States.
  • Although promotion of pediatric primary care clinicians (PCCs) in detection, management, and coordination of child mental health care is a strategy for improving access, limitations in training, time, and specialist availability represent substantial barriers.
  • The Massachusetts Child Psychiatry Access Project (MCPAP), publicly funded with 6 regional consultation teams, provides Massachusetts PCCs with rapid access to child psychiatry expertise, education, and referral assistance.
  • PCC surveys assessed satisfaction and impact on access to care.
  • RESULTS: The MCPAP enrolled 1341 PCCs in 353 practices covering 95% of the youth in Massachusetts.
  • PCCs contacted the MCPAP for diagnostic questions (34%), identifying community resources (27%), and consultation regarding medication (27%).
  • The rate of PCCs who reported that they are usually able to meet the needs of psychiatric patients increased from 8% to 63%.
  • Consultations were reported to be helpful by 91% of PCCs.
  • CONCLUSIONS: PCCs have used and value a statewide system that provides access to teams of psychiatric consultants.
  • Access to child mental health care may be substantially improved through public health interventions that promote collaboration between PCCs and child mental health specialists.

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  • (PMID = 21059722.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Kim YM, Kwak KH, Lim JO, Baek WY: Reduction of allodynia by intrathecal transplantation of microencapsulated porcine chromaffin cells. Artif Organs; 2009 Mar;33(3):240-9
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  • [Title] Reduction of allodynia by intrathecal transplantation of microencapsulated porcine chromaffin cells.
  • Bovine chromaffin cells (BCCs) are well known to have analgesic effect to reduce acute or chronic pain when transplanted in the subarachnoid space and have been considered as an alternative therapy for pain management.
  • In the present study, we investigated whether microencapsulated porcine adrenal medullary chromaffin cells (PCCs) also have analgesic effect to reduce allodynia caused by neuropathic pain in chronic constriction injury model of rat.
  • PCCs were isolated from a porcine adrenal medulla and then microencapsulated with alginate and poly.
  • In in vitro tests, the microencapsulated PCCs were investigated whether they have an ability to release catecholamines responding to nicotine stimulation.
  • The levels of catecholamines released from the microencapsulated PCCs were significantly higher than from microencapsulated BCCs.
  • In addition, the microencapsulated PCCs released catecholamines and met-enkephalin responding to cerebral spinal fluid (CSF) retrieved from a neuropathic pain model.
  • In in vivo tests, implantation of microencapsulated PCCs reduced both mechanical and cold allodynia in chronic constriction injury model of a rat whereas the microencapsulated BCCs reduced only cold allodynia under the same conditions.
  • The injection of antagonist of opioid peptides reversed the reduction of cold allodynia in microencapsulated PCC-received animal.
  • The levels of catecholamines in the CSF of rats after implantation of microencapsulated PCCs were significantly higher than in the control group.
  • These data suggest that microencapsulated PCCs may be another effective source for the treatment of neuropathic pain.
  • [MeSH-major] Cell- and Tissue-Based Therapy / methods. Chromaffin Cells / cytology. Chromaffin Cells / transplantation. Pain
  • [MeSH-minor] Animals. Behavior, Animal. Catecholamines / metabolism. Cattle. Cells, Cultured. Cerebrospinal Fluid / chemistry. Cerebrospinal Fluid / metabolism. Male. Models, Animal. Nicotine / metabolism. Polylysine / chemistry. Rats. Rats, Sprague-Dawley. Swine

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  • (PMID = 19245523.001).
  • [ISSN] 1525-1594
  • [Journal-full-title] Artificial organs
  • [ISO-abbreviation] Artif Organs
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catecholamines; 25104-18-1 / Polylysine; 6M3C89ZY6R / Nicotine
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26. Wonderlin WF: Constitutive, translation-independent opening of the protein-conducting channel in the endoplasmic reticulum. Pflugers Arch; 2009 Feb;457(4):917-30
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  • Secretory and membrane proteins are translocated into the endoplasmic reticulum (ER) through a translocon assembled as a tetramer of Sec61 protein-conducting channels (PCC).
  • How the opening of the PCCs in the tetramer is regulated through the protein translocation cycle is poorly understood.
  • In this study, the permeability of PCCs in native ER membranes to small molecules was measured using fluorescence and electrophysiological techniques.
  • Although the PCCs were closed at 4 degrees C, they were constitutively open at physiological temperatures in the absence of protein translation or a bound ribosome.
  • The open PCCs occurred in clusters that are likely to correspond to the simultaneous opening of three or four PCCs in a translocon.
  • The binding of 60S subunits to a ribosome-free membrane increased the number of open PCCs but did not increase the single-channel conductance.
  • The translation-independent, constitutive opening of Sec61 PCCs provides new insight into the role of the translocon in the transport of small molecules across the ER membrane.

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  • (PMID = 18604553.001).
  • [ISSN] 0031-6768
  • [Journal-full-title] Pflügers Archiv : European journal of physiology
  • [ISO-abbreviation] Pflugers Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Protein Subunits; 0 / SEC61 protein
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27. Federlin M, Hiller KA, Schmalz G: Controlled, prospective clinical split-mouth study of cast gold vs. ceramic partial crowns: 5.5 year results. Am J Dent; 2010 Jun;23(3):161-7
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  • PURPOSE: To investigate the long-term clinical performance of cast gold partial crowns (CGPCs) as compared to partial ceramic crowns (PCCs).
  • The null hypothesis tested was that CGPCs and PCCs would show similar clinical outcomes.
  • In each patient, one CGPC (Degulor C) and one PCC (Vita Mark II ceramic/Cerec 3) had been inserted at baseline.
  • After 5.5 years, 22 CGPC and 22 PCC restorations in 22 subjects attending the recall visit were clinically assessed using modified United States Public Health Service (USPHS) criteria.
  • Kaplan-Meier survival rates were calculated for CGPCs and PCCs of the 29 subjects who had been originally enrolled in the study.
  • 22 CGPCs and 11 PCCs were placed in molars; 11 PCCs were placed in premolars.
  • After 5.5 years, PCCs revealed a statistically significant, time dependant decrease of Alfa ratings for criteria anatomic form, marginal adaptation and marginal discoloration.
  • Furthermore, PCCs as compared to CGPCs showed a statistically significant material-related decrease of Alfa ratings for criteria anatomic form and marginal discoloration.
  • Kaplan-Meier survival analysis revealed a 93.3% cumulative survival rate for CGPCs and an 88.8% cumulative survival rate for PCCs after 5.5 years.
  • At 5.5 years, CGPCs and PCCs exhibited satisfactory clinical outcomes.
  • For PCCs, Bravo ratings increased significantly over time, however this did not compromise clinical survival of the restorations as compared to CGPCs.

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  • (PMID = 20718214.001).
  • [ISSN] 0894-8275
  • [Journal-full-title] American journal of dentistry
  • [ISO-abbreviation] Am J Dent
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gold Alloys; 12001-21-7 / Dental Porcelain
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28. Levy JH, Tanaka KA, Dietrich W: Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology; 2008 Nov;109(5):918-26
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  • European and American guidelines recommend prothrombin complex concentrates (PCCs) for anticoagulation reversal in patients with life-threatening bleeding and an increased international normalized ratio.
  • Compared with human fresh frozen plasma, PCCs provide quicker correction of the international normalized ratio and improved bleeding control.
  • Although there are historic concerns regarding potential infectious and thrombotic risks with PCCs, current PCC formulations are much improved.
  • Recombinant activated factor VII is a potential alternative to PCCs, but preclinical comparisons suggest that PCCs are more effective in correcting coagulopathy.
  • Although many patients who require rapid reversal of warfarin are currently treated with fresh frozen plasma, PCCs should be considered as an alternative therapy.
  • [MeSH-major] Hemostatics / therapeutic use. Perioperative Care / methods. Vitamin K / antagonists & inhibitors
  • [MeSH-minor] Blood Coagulation / drug effects. Blood Coagulation / physiology. Blood Coagulation Factors / pharmacology. Blood Coagulation Factors / therapeutic use. Blood Loss, Surgical / physiopathology. Blood Loss, Surgical / prevention & control. Disease Management. Humans. International Normalized Ratio / methods. Warfarin / adverse effects. Warfarin / antagonists & inhibitors

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  • (PMID = 18946305.001).
  • [ISSN] 1528-1175
  • [Journal-full-title] Anesthesiology
  • [ISO-abbreviation] Anesthesiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Coagulation Factors; 0 / Hemostatics; 12001-79-5 / Vitamin K; 37224-63-8 / prothrombin complex concentrates; 5Q7ZVV76EI / Warfarin
  • [Number-of-references] 71
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29. De Krijger RR, Petri BJ, Van Nederveen FH, Korpershoek E, De Herder WW, De Muinck Keizer-Schrama SM, Dinjens WN: Frequent genetic changes in childhood pheochromocytomas. Ann N Y Acad Sci; 2006 Aug;1073:166-76
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  • [Title] Frequent genetic changes in childhood pheochromocytomas.
  • Pheochromocytomas (PCCs) are rare catecholamine-producing tumors of the adrenal gland which may also occur elsewhere in the abdomen and are then called paragangliomas.
  • A proportion of PCCs occurs in hereditary cancer syndromes, including multiple endocrine neoplasia Type 2 (MEN2), caused by mutations in the RET proto-oncogene, von Hippel-Lindau (VHL) disease, caused by VHL gene abnormalities, and the pheochromocytoma-paraganglioma (PCC-PGL) syndrome, caused by mutations in SDHB and SDHD.
  • Since a proportion of PCCs occurs in children we hypothesized that germline mutations in RET, VHL, succinate dehydrogenase subunit B (SDHB), and subunit D (SDHD) occur more frequently in the pediatric age range.
  • From our single-institution collection of PCCs, we have selected 10 cases that occurred in individuals up to 18 years of age at diagnosis.
  • In these, we have performed mutation analysis on normal and tumor tissues for exons 10, 11, and 16 of RET and for the entire coding sequence of VHL, SDHB, and SDHD.
  • In the remaining 7 patients there was one patient from a family fulfilling the clinical criteria for VHL disease.
  • All tumors were benign (average follow-up: 12 years) and were located in the adrenal.
  • From our findings we conclude that (a) a large proportion (40%) of pediatric PCC patients is diagnosed in the context of inherited cancer syndromes, and (b) candidate gene analysis appears to be indicated to detect germline mutations.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Base Sequence. Child. DNA Primers. Electrophoresis, Polyacrylamide Gel. Genetic Predisposition to Disease. Humans. Polymorphism, Single-Stranded Conformational. Proto-Oncogene Proteins c-ret / genetics. Succinate Dehydrogenase / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • [ErratumIn] Ann N Y Acad Sci. 2006;1086:241. Petri, Bart-Jeroen [added]
  • (PMID = 17102083.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; EC 1.3.99.1 / Succinate Dehydrogenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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30. Antedomenico E, Wascher RA: A case of mistaken identity: giant cystic pheochromocytoma. Curr Surg; 2005 Mar-Apr;62(2):193-8
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  • [Title] A case of mistaken identity: giant cystic pheochromocytoma.
  • The patient denied a personal or family history of pancreatic or endocrine disease.
  • Based on these findings and the patient's history, a cystic neoplasm of the pancreas was suspected, and she was subsequently taken to the operating room for exploration.
  • Histopathological evaluation confirmed the diagnosis of cystic pheochromocytoma (PCC).
  • Cystic PCCs may not present with the classic prodromal symptoms associated with solid PCCs.
  • This case represents the complex and unsuspected presentation of an extremely rare functional cystic neoplasm.
  • A high index of suspicion for cystic PCC is necessary when confronted with cystic lesions in the vicinity of the adrenal glands.
  • Failure to recognize cystic PCC before resection may lead to uncontrollable hypertension in the operating room, with potentially serious consequences.
  • [MeSH-major] Diagnostic Errors. Pheochromocytoma / diagnosis
  • [MeSH-minor] Adrenal Gland Neoplasms. Adult. Antihypertensive Agents / administration & dosage. Female. Humans. Hypertension / drug therapy. Hypertension / etiology. Infusions, Intravenous. Nitroprusside / administration & dosage. Surgical Procedures, Operative. Tomography, X-Ray Computed

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  • (PMID = 15796940.001).
  • [ISSN] 0149-7944
  • [Journal-full-title] Current surgery
  • [ISO-abbreviation] Curr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 169D1260KM / Nitroprusside
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31. Petri BJ, van Eijck CH, de Herder WW, Wagner A, de Krijger RR: Phaeochromocytomas and sympathetic paragangliomas. Br J Surg; 2009 Dec;96(12):1381-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: About 24 per cent of phaeochromocytomas (PCCs) and sympathetic paragangliomas (sPGLs) appear in familial cancer syndromes, including multiple endocrine neoplasia type 2, von Hippel-Lindau disease, neurofibromatosis type 1 and PCC-paraganglioma syndrome.
  • Surgical resection is the treatment of choice for both PCC and sPGL, but controversy exists about the management of patients with bilateral or multiple tumours.
  • METHODS: Relevant medical literature from PubMed, Ovid and Embase websites until 2009 was reviewed for articles on PCC, sPGL, hereditary syndromes and their treatment.
  • DISCUSSION: Genetic testing for these syndromes should become routine clinical practice for those with PCC or sPGL.
  • The preferred treatment of PCC and PGL is surgical resection; to avoid the lifelong consequences of bilateral adrenalectomy, cortex-sparing adrenalectomy is the treatment of choice.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Multiple Endocrine Neoplasia Type 2a / surgery. Nervous System Neoplasms / surgery. Paraganglioma / surgery. von Hippel-Lindau Disease / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Genetic Testing. Humans. Infant. Middle Aged. Mutation / genetics. Pheochromocytoma / diagnosis. Pheochromocytoma / genetics. Pheochromocytoma / surgery. Syndrome

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  • [Copyright] Copyright (c) 2009 British Journal of Surgery Society Ltd.
  • (PMID = 19918850.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 93
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32. Ceyhan GO, Demir IE, Altintas B, Rauch U, Thiel G, Müller MW, Giese NA, Friess H, Schäfer KH: Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells. Biochem Biophys Res Commun; 2008 Sep 26;374(3):442-7
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  • Neural invasion by pancreatic cancer cells (PCC) worsens the prognosis and frequently limits curative resection.
  • We established a novel in-vitro model in which T3M4-PCCs were co-cultured with either isolated myenteric plexus cells (MP) or dorsal root ganglia (DRG) of newborn rats within a three-dimensional extracellular matrix gel.
  • The close vicinity of MP or DRG to T3M4-PCCs induced early morphologic changes on T3M4-PCCs at the migration front prior to the migration process with elongated and neurite-targeting PCCs, compared to round and non-grouping at the non-migrating front.
  • T3M4-PCCs built cancer-cell clusters around the DRG or MP, a process which was accelerated by increasing number of T3M4-PCCs or neurons.
  • These findings indicate that neuro-cancer interactions start prior to PCC migration and induce evident changes in cancer and nerve biology.
  • These findings can be reproduced within the introduced 3D in-vitro migration assay which allows investigation in the early pathogenesis of neural PCC invasion.
  • [MeSH-minor] Animals. Cell Line, Tumor. Coculture Techniques. Ganglia, Spinal / pathology. Glial Cell Line-Derived Neurotrophic Factor. Humans. Myenteric Plexus / pathology. Neoplasm Invasiveness. Nerve Growth Factor / pharmacology. Rats. Rats, Sprague-Dawley. Tropism

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  • (PMID = 18640096.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Cell Line-Derived Neurotrophic Factor; 9061-61-4 / Nerve Growth Factor
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33. van Nederveen FH, Perren A, Dannenberg H, Petri BJ, Dinjens WN, Komminoth P, de Krijger RR: PTEN gene loss, but not mutation, in benign and malignant phaeochromocytomas. J Pathol; 2006 Jun;209(2):274-80
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  • The gene is thought to be one of the most frequently mutated tumour suppressor genes and inactivation of PTEN is associated with disease progression and angiogenesis.
  • High vascularization and resistance to chemo- and radio-therapy are two well-established features of phaeochromocytomas (PCCs).
  • Furthermore, benign and malignant PCCs are found in several PTEN knockout mouse models.
  • This study therefore evaluated whether inactivation of PTEN may be involved in the tumourigenesis of PCC in man and whether PTEN abnormalities may help to define the malignant potential of these tumours.
  • Tumour and germline DNA was analysed from 31 patients with apparently sporadic PCC, including 14 clinically benign and 17 malignant tumours, for loss of the PTEN gene locus, mutations in the PTEN gene, and for PTEN protein expression by immunohistochemistry.
  • Loss of heterozygosity (LOH) analysis showed loss of PTEN in four malignant tumours (40%) and in one benign tumour (14%).
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genes, Tumor Suppressor / physiology. Neoplasm Proteins / genetics. PTEN Phosphohydrolase / genetics. Pheochromocytoma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. DNA Mutational Analysis / methods. DNA, Neoplasm / genetics. Female. Gene Silencing / physiology. Humans. Immunohistochemistry / methods. Loss of Heterozygosity / genetics. Male. Middle Aged. Polymorphism, Single-Stranded Conformational

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  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 16538614.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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34. Oishi Y, Nagai S, Yoshida M, Fujisawa S, Sazawa A, Shinohara N, Nonomura K, Matsuno K, Shimizu C: Mutation analysis of the SDHB and SDHD genes in pheochromocytomas and paragangliomas: identification of a novel nonsense mutation (Q168X) in the SDHB gene. Endocr J; 2010;57(8):745-50
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  • [Title] Mutation analysis of the SDHB and SDHD genes in pheochromocytomas and paragangliomas: identification of a novel nonsense mutation (Q168X) in the SDHB gene.
  • Pheochromocytoma (PCC) and paraganglioma (PGL) are tumors of the autonomic nervous system.
  • The former is a tumor that occurs in only adrenal glands, and the latter can be found in the head and neck or in the thorax and abdomen.
  • In PCC and PGL, genetic mutations account for approximately 30% of functional (secrete catecholamines) and nonfunctional cases.
  • In addition to RET, VHL and NF-1, genes encoding succinate dehydrogenase complex subunit B (SDHB), subunit C (SDHC), and subunit D (SDHD) are recognized as susceptibility genes for PCC and PGL.
  • Recently, PCC and PGL caused by genetic mutations of SDHB, SDHC and SDHD were established as hereditary pheochromocytoma paraganglioma syndrome (HPPS).
  • Approximately 15% of all PCCs and PGLs are recognized as HPPS.
  • The aim of this study was to analyze SDHB and SDHD mutations in PCC and PGL patients.
  • A number of studies have reported that SDHB mutation-associated disease demonstrates a higher rate of malignancy.
  • [MeSH-major] Codon, Nonsense. Paraganglioma / genetics. Pheochromocytoma / genetics. Succinate Dehydrogenase / genetics
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / genetics. Adult. Aged. DNA Mutational Analysis. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Single Nucleotide. Sequence Analysis, DNA

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  • (PMID = 20505258.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Codon, Nonsense; 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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35. Suh KY, Lacouture M, Gerami P: p63 in Primary Cutaneous Carcinosarcoma. Am J Dermatopathol; 2007 Aug;29(4):374-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p63 in Primary Cutaneous Carcinosarcoma.
  • Primary cutaneous carcinosarcomas (PCCs) are rare malignant neoplasms that are characterized by biphasic epithelial and mesenchymal differentiation.
  • When the biphasic nature is not evident, immunohistochemical studies may be important in the diagnosis of PCCs.
  • We report 3 cases of PCC.
  • The clearly epithelial areas of each tumor were frequently positive for both markers, whereas the sarcomatous areas were negative for both markers.
  • These 3 cases suggest that the use of both p63 and routine cytokeratin markers such as AE1/AE3 can increase the sensitivity for distinguishing epithelial cells over a range of differentiation states, which we propose will aid in the diagnosis of PCCs.
  • In addition, the staining pattern of AE1/AE3 and p63 in these cases further supports the conversion theory of PCC.
  • [MeSH-major] Carcinosarcoma / pathology. DNA-Binding Proteins / analysis. Skin Neoplasms / pathology. Trans-Activators / analysis. Tumor Suppressor Proteins / analysis
  • [MeSH-minor] Aged. Aged, 80 and over. Anion Exchange Protein 1, Erythrocyte / analysis. Antiporters / analysis. Biomarkers, Tumor / analysis. Cell Differentiation. Epithelial Cells / pathology. Humans. Keratins / analysis. Male. Middle Aged. Transcription Factors. Vimentin / analysis

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  • (PMID = 17667171.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anion Exchange Protein 1, Erythrocyte; 0 / Antiporters; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / SLC4A3 protein, human; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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36. Schenke F, Federlin M, Hiller KA, Moder D, Schmalz G: Controlled, prospective, randomized, clinical evaluation of partial ceramic crowns inserted with RelyX Unicem with or without selective enamel etching. 1-year results. Am J Dent; 2010 Oct;23(5):240-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To compare the performance of partial ceramic crowns (PCCs) inserted with RelyX Unicem (RXU) either with (RXU+E) or without (RXU) selective enamel etching.
  • METHODS: 34 patients (15 male, 19 female) participated in the investigation, with a total of 68 PCC restorations.
  • In each patient, one PCC was randomly assigned to insertion with RXU, the second PCC was assigned to insertion with RXU+E.
  • The PCCs were CAD/CAM fabricated using the Cerec 3 system.
  • RXU: 25 PCCs were placed in molars, nine in premolars.
  • RXU+E: 26 PCCs were placed in molars, eight in premolars.
  • One PCC (RXU) debonded after 11 months in situ, one PCC (RXU+E) fractured after 12 months in situ.

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  • (PMID = 21207788.001).
  • [ISSN] 0894-8275
  • [Journal-full-title] American journal of dentistry
  • [ISO-abbreviation] Am J Dent
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Rely X Unicem; 0 / Resin Cements; 12001-21-7 / Dental Porcelain
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37. Kang SS, Conway PL: Characteristics of the adhesion of PCC Lactobacillus fermentum VRI 003 to Peyer's patches. FEMS Microbiol Lett; 2006 Aug;261(1):19-24

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  • [Title] Characteristics of the adhesion of PCC Lactobacillus fermentum VRI 003 to Peyer's patches.
  • The characteristics of the adhesion of PCC Lactobacillus fermentum VRI 003 to Peyer's patches was studied in vitro.

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  • (PMID = 16842353.001).
  • [ISSN] 0378-1097
  • [Journal-full-title] FEMS microbiology letters
  • [ISO-abbreviation] FEMS Microbiol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carbohydrates; 0 / Membrane Proteins; 0 / Methylmannosides; 51023-63-3 / methylmannoside; EC 3.4.21.64 / Endopeptidase K; PHA4727WTP / Mannose
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38. Holtman CK, Chen Y, Sandoval P, Gonzales A, Nalty MS, Thomas TL, Youderian P, Golden SS: High-throughput functional analysis of the Synechococcus elongatus PCC 7942 genome. DNA Res; 2005;12(2):103-15
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  • [Title] High-throughput functional analysis of the Synechococcus elongatus PCC 7942 genome.
  • Synechococcus elongatus PCC 7942 was the first cyanobacterial strain to be reliably transformed by exogenously added DNA and has become the model organism for cyanobacterial circadian rhythms.
  • With a small genome (2.7 Mb) and well-developed genetic tools, PCC 7942 provides an exceptional opportunity to elucidate the circadian mechanism through genetics.
  • Cosmid clones that carry inserts of PCC 7942 DNA are saturated with transposon insertions in vitro to provide sequencing templates and substrates for mutagenesis of the PCC 7942 genome via homologous recombination.
  • PCC 7942 mutants defective for 490 different genes have been screened for circadian phenotypes.

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  • (PMID = 16303742.001).
  • [ISSN] 1756-1663
  • [Journal-full-title] DNA research : an international journal for rapid publication of reports on genes and genomes
  • [ISO-abbreviation] DNA Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS39546; United States / NIGMS NIH HHS / GM / R01 GM59336
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Japan
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39. Chowdary P, Nair D, Davies N, Malde R, Gatt A: Anaphylactic reaction with prothrombin complex concentrate in a patient with IgA deficiency and anti-IgA antibodies. Blood Coagul Fibrinolysis; 2010 Dec;21(8):764-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaphylactic reaction with prothrombin complex concentrate in a patient with IgA deficiency and anti-IgA antibodies.
  • Immunoglobulin A (IgA) deficiency with anti-IgA antibodies is not listed as an absolute or relative contraindication for the use of prothrombin complex concentrates (PCCs).
  • We discuss a patient who developed an anaphylactic reaction to PCC on a background of selective IgA deficiency with anti-IgA antibodies and with a history of anaphylactic reaction to other blood products.
  • Further analysis of PCCs revealed the presence of variable quantities of immunoglobulins of all classes, including IgA.
  • Although the summary of product characteristics for PCCs from various manufacturers does not list IgA deficiency with anti-IgA antibodies as an absolute or relative contraindication, our findings suggest that PCCs are not devoid of IgA and great caution must be exercised with their use in patients with IgA deficiency with anti-IgA antibodies and with previously documented reactions.

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  • (PMID = 20885296.001).
  • [ISSN] 1473-5733
  • [Journal-full-title] Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
  • [ISO-abbreviation] Blood Coagul. Fibrinolysis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Blood Coagulation Factors; 0 / anti-IgA; 37224-63-8 / prothrombin complex concentrates
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40. Dargaud Y, Desmurs-Clavel H, Marin S, Bordet JC, Poplavsky JL, Negrier C: Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study. J Thromb Haemost; 2008 Jun;6(6):962-8
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  • [Title] Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study.
  • BACKGROUND: Human prothrombin complex concentrates (PCCs) are used for prevention and treatment of bleeding episodes in patients under warfarin therapy.
  • PCCs contain human factor (F) II, FVII, FIX, FX, protein C and protein S.
  • The concentrations of these coagulation factors contained in PCCs are variable and do not reflect entirely the capacity of these drugs to correct hemostasis.
  • Furthermore, commercially available PCCs do not have exactly the same composition, though they are all labelled and prescribed in units per kg of FIX (10-40 IU of FIX/kg).
  • As the final product generated by PCCs is thrombin, a thrombin generation (TG) test could theoretically be used for monitoring the hemostatic correction.
  • METHODS: TG was measured in platelet free plasma in the presence of tissue factor 5 pm and phospholipids 4 microM with a final concentration of PCC of 0-0.1-0.2-0.3-0.4-0.5-0.75-1 IU ml(-1).
  • FII, FVII, FIX, FX, protein C and protein S) were determined for each concentration of two different PCCs available on the French market.
  • RESULTS AND DISCUSSION: Our results showed that the addition of two different PCCs dose-dependently increased the TG capacity in patients with INR of 2-2.5-3-4 and >7 (n = 15 subjects) that reached the normal values.
  • The two PCCs improved the TG parameters differently with increasing concentrations.
  • These results strongly suggest that TG assay could be used for monitoring the clinical efficacy of PCC and for optimizing the therapeutic regimen towards a more individualized therapy involving the type of the bleeding complications, the level of inhibition of the coagulation system and the molecule content of the PCC.

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  • (PMID = 18373620.001).
  • [ISSN] 1538-7836
  • [Journal-full-title] Journal of thrombosis and haemostasis : JTH
  • [ISO-abbreviation] J. Thromb. Haemost.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Blood Coagulation Factors; 0 / Enzyme Precursors; 0 / Protein C; 12001-79-5 / Vitamin K; 37224-63-8 / prothrombin complex concentrates; EC 3.4.21.5 / Thrombin
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41. Zhang HY, Wang SJ, Xing J, Liu B, Ma ZL, Yang M, Zhang ZJ, Teng GJ: Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease. Behav Brain Res; 2009 Jan 30;197(1):103-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease.
  • Resting-state networks dissociate in the early stage of Alzheimer's disease (AD).
  • The posterior cingulate cortex (PCC) in AD brain is vulnerable to isolation from the rest of brain.
  • However, it remains unclear how this functional connectivity is related to PCC changes.
  • We employed resting-state functional MRI (fMRI) to examine brain regions with a functional connection to PCC in a mild AD group compared with matched control subjects.
  • PCC connectivity was gathered by investigating synchronic low frequency fMRI signal fluctuations with a temporal correlation method.
  • We found asymmetric PCC-left hippocampus, right dorsal-lateral prefrontal cortex and right thalamus connectivity disruption.
  • In addition, some other regions such as the bilateral visual cortex, the infero-temporal cortex, the posterior orbital frontal cortex, the ventral medial prefrontal cortex and the precuneus showed decreased functional connectivity to the PCC.
  • These regions included the medial prefrontal cortex, bilateral dorsal-lateral prefrontal cortex, the left basal ganglia and the left primary motor cortex.
  • [MeSH-major] Alzheimer Disease / physiopathology. Brain Mapping. Gyrus Cinguli / physiology. Nerve Net / physiology. Neural Pathways / physiology. Rest / physiology

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  • (PMID = 18786570.001).
  • [ISSN] 1872-7549
  • [Journal-full-title] Behavioural brain research
  • [ISO-abbreviation] Behav. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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42. Liu X, Curtiss R 3rd: Nickel-inducible lysis system in Synechocystis sp. PCC 6803. Proc Natl Acad Sci U S A; 2009 Dec 22;106(51):21550-4
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  • [Title] Nickel-inducible lysis system in Synechocystis sp. PCC 6803.
  • PCC 6803 to facilitate extracting lipids for biofuel production.
  • Several bacteriophage-derived lysis genes were integrated into the genome and placed downstream of a nickel-inducible signal transduction system.
  • PCC 6803 cells with this system by the addition of NiSO(4).

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  • (PMID = 19995962.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biofuels; 4FLT4T3WUN / nickel sulfate; 7OV03QG267 / Nickel
  • [Other-IDs] NLM/ PMC2799798
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43. Van Nederveen FH, Dinjens WN, Korpershoek E, De Krijger RR: The occurrence of SDHB gene mutations in pheochromocytoma. Ann N Y Acad Sci; 2006 Aug;1073:177-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The occurrence of SDHB gene mutations in pheochromocytoma.
  • Pheochromocytomas (PCCs) are rare tumors arising from neural crest-derived chromaffin cells.
  • The majority of these tumors are located in the adrenals and gives rise to catecholamine overproduction.
  • In at least 10% of the cases the tumors are located outside the adrenal gland, in extra-adrenal sites like the bladder and the organ of Zuckerkandl.
  • Recent investigations have found mutations in succinate dehydrogenase subunit B (SDHB), the gene coding for subunit B of the respiratory chain complex II.
  • Mutations in the SDHB gene, with additional loss of the wild-type allele, result in loss of function of respiratory complex II and appear to correlate with extra-adrenal location of PCCs.
  • Also, a link has been established between malignant behavior and inactivating mutations of SDHB.
  • In this article we review the published SDHB gene mutations, as well as the location and behavior of the resulting PCCs.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Mutation. Pheochromocytoma / genetics. Succinate Dehydrogenase / genetics

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  • (PMID = 17102084.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.3.99.1 / Succinate Dehydrogenase
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44. Janssen PJ, Morin N, Mergeay M, Leroy B, Wattiez R, Vallaeys T, Waleron K, Waleron M, Wilmotte A, Quillardet P, de Marsac NT, Talla E, Zhang CC, Leys N: Genome sequence of the edible cyanobacterium Arthrospira sp. PCC 8005. J Bacteriol; 2010 May;192(9):2465-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genome sequence of the edible cyanobacterium Arthrospira sp. PCC 8005.
  • PCC 8005, a cyanobacterial strain of great interest to the European Space Agency for its nutritive value and oxygenic properties in the Micro-Ecological Life Support System Alternative (MELiSSA) biological life support system for long-term manned missions into space.

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  • [Cites] Nucleic Acids Res. 2006;34(1):53-65 [16407324.001]
  • [Cites] Appl Environ Microbiol. 2008 Oct;74(19):6102-13 [18676712.001]
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  • (PMID = 20233937.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ ADDH01000000
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2863490
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45. Nakasugi K, Alexova R, Svenson CJ, Neilan BA: Functional analysis of PilT from the toxic cyanobacterium Microcystis aeruginosa PCC 7806. J Bacteriol; 2007 Mar;189(5):1689-97
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  • [Title] Functional analysis of PilT from the toxic cyanobacterium Microcystis aeruginosa PCC 7806.
  • Since the microcystin-producing Microcystis aeruginosa PCC 7806 is naturally transformable, we have initiated the characterization of its type IV pilus system, involved in DNA uptake in many bacteria, to provide a physiological focus for the influence of gene transfer in microcystin evolution.
  • The type IV pilus genes pilA, pilB, pilC, and pilT were shown to be expressed in M. aeruginosa PCC 7806.
  • Heterologous expression indicated that it could complement the pilT mutant of Pseudomonas aeruginosa, but not that of the cyanobacterium Synechocystis sp. strain PCC 6803, which was unexpected.
  • Differences in two critical residues between the M. aeruginosa PCC 7806 PilT (7806 PilT) and the Synechocystis sp. strain PCC 6803 PilT proteins affected their theoretical structural models, which may explain the nonfunctionality of 7806 PilT in its cyanobacterial counterpart.

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  • (PMID = 17172325.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ DQ666165/ DQ666166/ DQ666168/ DQ666169/ EF051581/ EF051582/ EF058234
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Molecular Motor Proteins; EC 3.6.1.- / Adenosine Triphosphatases
  • [Other-IDs] NLM/ PMC1855755
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46. Claesson C, Hällgren A, Nilsson M, Svensson E, Hanberger H, Nilsson LE, Scope Study Group: Susceptibility of staphylococci and enterococci to antimicrobial agents at different ward levels in four north European countries. Scand J Infect Dis; 2007;39(11-12):1002-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A multicentre susceptibility study was performed on staphylococci and enterococci isolated from patients at 3 different ward levels: primary care centres (PCCs), general hospital wards (GHWs) and intensive care units (ICUs), in Denmark, Finland, Norway and Sweden.
  • There was a markedly higher incidence of resistance among CoNS in ICUs compared to GHWs and PCCs.
  • The prevalence of E. faecium isolates in this study differed significantly between the ward levels with the lowest prevalence found at PCCs.
  • The HLGR rate was significantly higher among E. faecalis from hospitalized patients (GHWs and ICUs) compared to patients at PCCs.

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  • (PMID = 17852944.001).
  • [ISSN] 0036-5548
  • [Journal-full-title] Scandinavian journal of infectious diseases
  • [ISO-abbreviation] Scand. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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47. Przybylik-Mazurek E, Buziak-Bereza M, Stochmal E, Budzyński A, Białas M, Kostecka-Matyja M, Hubalewska-Dydejczyk A: [Diagnostic difficulties in recognizing of pheochromocytoma]. Przegl Lek; 2010;67(12):1276-81
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic difficulties in recognizing of pheochromocytoma].
  • Pheochromocytoma (PH) is a tumour of chromaffin cells of the sympathetic nervous system and its clinical symptoms are associated with excessive production and release of catecholamines.
  • The main criterion for clinical diagnosis of PH is finding increased concentrations of catecholamines or their metabolites in serum and/or urine.
  • Aim of this study was to determine the cut-off point for elevated methoxycatecholamine in the collection of daily urine, which would give the basis for determining the reasonable recommendations of the biochemical criteria for diagnosis of PH.
  • Retrospectively we analysed the results of 45 patients sent to laparoscopic adrenalectomy to the Department of General Surgery II with the preoperative diagnosis of pheochromocytoma.
  • The diagnosis of pheochromocytoma was based on the finding of elevated 24-hour urine methoxycatecholamines.
  • Group 1 included 27 patients (14 women and 13 men) with histopathologically confirmed pheochromocytoma of adrenal gland.
  • Group 2 consisted of 18 patients (11 women and 7 men), in which histopathological examination did not confirm the presence of pheochromocytoma.
  • Based on the analyzed results of the CT, we found that the average tumor size in group 1 (4.2 +/- 1.9 cm) was statistically higher than in group 2 (2.9 +/- 1.1 cm).
  • The average concentration of normetanephrine (NMN) in 24-hour urine in group 1 was statistically significantly higher than in group 2 (2,686 +/- 870.4 vs. 2375.1 +/- 754 mg/24h), as well as the average concentration of metanephrine (MN) (2533.4 +/- 3269.3 +/- 491.6 vs. 371.5 mg/24 hrs), and the sum of both methoxycatecholamines (NMN + MN) (5219.3 +/- 5190.6 vs. 1241.8 +/- 1202.2).
  • The highest sensitivity in diagnosing pheochromocytoma with the rate of 81.5% was obtained for the sum of normetanephrine and metanephrine in 24-hour urine, while the sensivity for levels of each methoxycatecholamine separately was similar (63%).
  • The highest specificity in the exclusion of PH was shown for 24-hour urine metanephrine (94.4%).
  • The diagnostic cutoff concentrations of NMN, MN and NMN + MN for the diagnosis of pheochromocytoma were set.
  • Shown above cut-off levels of methoxycatecholamines urine concentration will allow to pose a more accurate preoperative diagnosis of PH.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / urine. Normetanephrine / urine. Pheochromocytoma / diagnosis. Pheochromocytoma / urine
  • [MeSH-minor] Adolescent. Adrenalectomy. Adult. Aged. Biomarkers, Tumor / blood. Biomarkers, Tumor / urine. Catecholamines / blood. Catecholamines / urine. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 21591353.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Catecholamines; 0J45DE6B88 / Normetanephrine
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48. Tabei Y, Okada K, Tsuzuki M: Sll1330 controls the expression of glycolytic genes in Synechocystis sp. PCC 6803. Biochem Biophys Res Commun; 2007 Apr 20;355(4):1045-50
Hazardous Substances Data Bank. GLUCOSE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sll1330 controls the expression of glycolytic genes in Synechocystis sp. PCC 6803.
  • PCC 6803, one can find many putative genes for two-component response regulators that include a helix-turn-helix DNA-binding domain.
  • PCC 6803 genome each encodes two isozymes for these five glycolytic genes, suggesting that each of the two isozymes is regulated by Sll1330 at the mRNA level.

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  • (PMID = 17331473.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA, Bacterial; 0 / RNA, Messenger; IY9XDZ35W2 / Glucose
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49. Brecht M, Radics V, Nieder JB, Studier H, Bittl R: Red antenna states of photosystem I from Synechocystis PCC 6803. Biochemistry; 2008 May 20;47(20):5536-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Red antenna states of photosystem I from Synechocystis PCC 6803.
  • Emission spectra of single PSI complexes from the cyanobacterium Synechocystis PCC 6803 show zero-phonon lines (ZPLs) as well as broad intensity distributions without ZPLs.
  • The broad distributions dominating the red side of the spectra are made up of a low number of emitters assigned to the red-most pool C714.
  • The properties of F699 show close relation to those of F698 in Synechococcus PCC 7002 and C708 in Thermosynechococcus elongatus.
  • Furthermore, a high similarity is found between the C714 pool in Synechocystis PCC 6803 and C708 in Synechococcus PCC 7002 as well as C719 in T. elongatus.
  • [MeSH-major] Photosystem I Protein Complex / chemistry. Photosystem I Protein Complex / metabolism. Synechocystis / enzymology

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  • (PMID = 18429622.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosystem I Protein Complex
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50. Zang X, Liu B, Liu S, Arunakumara KK, Zhang X: Optimum conditions for transformation of Synechocystis sp. PCC 6803. J Microbiol; 2007 Jun;45(3):241-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optimum conditions for transformation of Synechocystis sp. PCC 6803.
  • This study was conducted to determine the optimal conditions for introduction of exogenous DNA into Synechocystis sp. PCC 6803.
  • Additionally, this study demonstrated that the higher plasmid concentration and longer homologous recombining fragments resulted in a greater number of transformants.
  • For successful transformation, the lowest concentration of plasmid was 0.02 microg/ml, and the shortest homologous recombining fragment was 0.2 kb.
  • PCC 6803 in the logarithmic growth phase resulted in two-fold higher transformation rate than that of the same organism when cells in the latent phase or the plateau phase were used for transformation.
  • PCC 6803, with EDTA (2 mM) for two days prior to transformation increased the transformation efficiency by 23%.

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  • (PMID = 17618230.001).
  • [ISSN] 1225-8873
  • [Journal-full-title] Journal of microbiology (Seoul, Korea)
  • [ISO-abbreviation] J. Microbiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / DNA, Bacterial; 9G34HU7RV0 / Edetic Acid
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51. Mimuro M, Yokono M, Akimoto S: Variations in photosystem I properties in the primordial cyanobacterium Gloeobacter violaceus PCC 7421. Photochem Photobiol; 2010 Jan-Feb;86(1):62-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Variations in photosystem I properties in the primordial cyanobacterium Gloeobacter violaceus PCC 7421.
  • We compared the optical properties of the trimeric photosystem (PS) I complexes of the primordial cyanobacterium Gloeobacter violaceus PCC 7421 with those of Synechocystis sp. PCC 6803.
  • The energy transfer kinetics in the antennae at physiological temperatures were very similar between the two species due to the thermal equilibrium within the antenna; however, they differed at 77 K where energy transfer to Red Chls was clearly observed in Synechocystis sp. PCC 6803.
  • [MeSH-major] Cyanobacteria / chemistry. Photosystem I Protein Complex / chemistry

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  • (PMID = 19769578.001).
  • [ISSN] 1751-1097
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosystem I Protein Complex
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52. Moslavac S, Reisinger V, Berg M, Mirus O, Vosyka O, Plöscher M, Flores E, Eichacker LA, Schleiff E: The proteome of the heterocyst cell wall in Anabaena sp. PCC 7120. Biol Chem; 2007 Aug;388(8):823-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The proteome of the heterocyst cell wall in Anabaena sp. PCC 7120.
  • Anabaena sp. PCC 7120 is a filamentous cyanobacterium that serves as a model to analyze prokaryotic cell differentiation, evolutionary development of plastids, and the regulation of nitrogen fixation.

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  • (PMID = 17655501.001).
  • [ISSN] 1431-6730
  • [Journal-full-title] Biological chemistry
  • [ISO-abbreviation] Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Proteome; 0 / Recombinant Fusion Proteins
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53. Saxena RK, Raghuvanshi R, Singh S, Bisen PS: Iron induced metabolic changes in the diazotrophic cyanobacterium Anabaena PCC 7120. Indian J Exp Biol; 2006 Oct;44(10):849-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Iron induced metabolic changes in the diazotrophic cyanobacterium Anabaena PCC 7120.
  • Iron induced changes in growth, N2-fixation, CO2 fixation and photosynthetic activity were studied in a diazotrophic cyanobacterium Anabaena PCC 7120.
  • Iron at 50 microM concentration supported the maximum growth, heterocyst frequency, CO2 fixation, photosystem I (PS I), photosystem II (PS II) and nitrogenase activities in the organism.
  • Higher concentration of iron inhibited these processes.

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  • (PMID = 17131917.001).
  • [ISSN] 0019-5189
  • [Journal-full-title] Indian journal of experimental biology
  • [ISO-abbreviation] Indian J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 1406-65-1 / Chlorophyll; 142M471B3J / Carbon Dioxide; E1UOL152H7 / Iron; YF5Q9EJC8Y / chlorophyll a
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54. Gotoh E: Drug-induced premature chromosome condensation (PCC) protocols: cytogenetic approaches in mitotic chromosome and interphase chromatin. Methods Mol Biol; 2009;523:83-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Drug-induced premature chromosome condensation (PCC) protocols: cytogenetic approaches in mitotic chromosome and interphase chromatin.
  • Premature chromosome condensation (PCC) is an alternative method that has proved to be a unique and useful way in chromosome analysis.
  • Usually, PCC has been achieved following cell fusion mediated either by fusogenic viruses or by polyethylene glycol (cell-fusion PCC), but the cell-fusion PCC has several drawbacks.
  • The novel drug-induced PCC using protein phosphatase inhibitors was introduced about 10 years ago.
  • This method is much simple and easy even than the conventional mitotic chromosome preparation using colcemid block protocol and obtained PCC index (equivalent to mitotic index for metaphase chromosome) is much higher.
  • The drug-induced PCC has therefore proven the usefulness in cytogenetics and other cell biology fields.

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  • (PMID = 19381920.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin; 0 / Oxazoles; 101932-71-2 / calyculin A
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55. Jansén T, Kidron H, Taipaleenmäki H, Salminen T, Mäenpää P: Transcriptional profiles and structural models of the Synechocystis sp. PCC 6803 Deg proteases. Photosynth Res; 2005 Jun;84(1-3):57-63

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcriptional profiles and structural models of the Synechocystis sp. PCC 6803 Deg proteases.
  • PCC 6803 genome harbours a deg gene family consisting of three members, degP (htrA, slr1204), degQ (hhoA, sll1679) and degS (hhoB, sll1427).
  • PCC 6803 deg genes at the level of transcription and protein structures of the gene products to evaluate their hypothetical role in D1 protein turnover.
  • PCC 6803 Deg proteases were predicted based on an amino acid sequence alignment and comparison of the Deg crystal structures from human, Escherichia coli and Thermotoga maritima.
  • PCC 6803 Degs resemble more the Thermotoga maritima Deg enzyme structure than the Escherichia coli one.
  • PCC 6803 Deg proteases.

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  • (PMID = 16049755.001).
  • [ISSN] 0166-8595
  • [Journal-full-title] Photosynthesis research
  • [ISO-abbreviation] Photosyn. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.4.- / Peptide Hydrolases
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56. Adamoli AN, Azevedo MR: [Patterns of physical activity of people with chronic mental and behavioral disorders]. Cien Saude Colet; 2009 Jan-Feb;14(1):243-51
MedlinePlus Health Information. consumer health - Mental Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Padrões de atividade física de pessoas com transtornos mentais e de comportamento.
  • Since physical activity (PA) is capable of improving both the quality of life and the prognosis for individuals with mental and behavioral disorders (MBD), the main purpose of this study was to analyze the PA patterns in individuals with MBD frequenting a Psychosocial Care Center (PCC) in the city of Pelotas.
  • The target population of this descriptive study consisted of individuals attended in any of the PCCs of Pelotas.
  • The sample was selected from six PCCs and comprised 85 patients and their relatives.
  • Men participated more in the PA offered by the PCC than women.
  • Therefore, incorporation of PA in PCC seems to be a feasible initiative for supporting the treatment of these patients and would offer a unique opportunity for the patients to engage in supervised and structured PA programs.
  • [MeSH-minor] Adult. Chronic Disease. Female. Humans. Life Style. Male. Middle Aged

  • Genetic Alliance. consumer health - Behavioral Disorders.
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  • (PMID = 19142328.001).
  • [ISSN] 1678-4561
  • [Journal-full-title] Ciência & saúde coletiva
  • [ISO-abbreviation] Cien Saude Colet
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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57. Koyama K, Tsuchiya T, Akimoto S, Yokono M, Miyashita H, Mimuro M: New linker proteins in phycobilisomes isolated from the cyanobacterium Gloeobacter violaceus PCC 7421. FEBS Lett; 2006 Jun 12;580(14):3457-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New linker proteins in phycobilisomes isolated from the cyanobacterium Gloeobacter violaceus PCC 7421.
  • Two new linker proteins were identified by peptide mass fingerprinting in phycobilisomes isolated from the cyanobacterium Gloeobacter violaceus PCC 7421.

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  • (PMID = 16714023.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Phycobilisomes
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58. Liang CW, Zhang XW, Tian L, Qin S: Functional characterization of sll0659 from Synechocystis sp. PCC 6803. Indian J Biochem Biophys; 2008 Aug;45(4):275-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional characterization of sll0659 from Synechocystis sp. PCC 6803.
  • PCC 6803 lacks a gene for the any known types of lycopene cyclase.

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  • (PMID = 18788479.001).
  • [ISSN] 0301-1208
  • [Journal-full-title] Indian journal of biochemistry & biophysics
  • [ISO-abbreviation] Indian J. Biochem. Biophys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Bacterial Proteins; 01YAE03M7J / beta Carotene; EC 5.5.- / Intramolecular Lyases; EC 5.5.- / lycopene cyclase-isomerase
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59. Agrawal MK, Zitt A, Bagchi D, Weckesser J, Bagchi SN, von Elert E: Characterization of proteases in guts of Daphnia magna and their inhibition by Microcystis aeruginosa PCC 7806. Environ Toxicol; 2005 Jun;20(3):314-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of proteases in guts of Daphnia magna and their inhibition by Microcystis aeruginosa PCC 7806.
  • An extract from Microcystis aeruginosa strain PCC 7806 inhibited both types of D. magna proteases.

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 15892063.001).
  • [ISSN] 1520-4081
  • [Journal-full-title] Environmental toxicology
  • [ISO-abbreviation] Environ. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Toxins; 0 / Enzyme Inhibitors; 0 / Proteins; EC 3.4.- / Peptide Hydrolases; EC 3.4.21.1 / Chymotrypsin; EC 3.4.21.4 / Trypsin
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60. Kim JA, Han GC, Lim M, You KS, Ryu M, Ahn JW, Fujita T, Kim H: Effect of hydraulic activity on crystallization of precipitated calcium carbonate (PCC) for eco-friendly paper. Int J Mol Sci; 2009 Nov;10(11):4954-62
Hazardous Substances Data Bank. CALCIUM CARBONATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of hydraulic activity on crystallization of precipitated calcium carbonate (PCC) for eco-friendly paper.
  • Wt% of aragonite, a CaCO(3) polymorph, increased with higher hydraulic activity ( degrees C) of limestone in precipitated calcium carbonate (PCC) from the lime-soda process (Ca(OH)(2)-NaOH-Na(2)CO(3)).
  • The crystallization of PCC is more dependent on the hydraulic activity of limestone than CaO content, a factor commonly used to classify limestone ores according to quality.
  • The results could be effectively applied to the determination of polymorphs in synthetic PCC for eco-friendly paper manufacture.
  • [MeSH-minor] Calcium Compounds / chemistry. Crystallization. Industry. Oxides / chemistry. Temperature

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  • [Cites] Talanta. 1996 Sep;43(9):1497-509 [18966629.001]
  • (PMID = 20087470.001).
  • [ISSN] 1422-0067
  • [Journal-full-title] International journal of molecular sciences
  • [ISO-abbreviation] Int J Mol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Calcium Compounds; 0 / Oxides; C7X2M0VVNH / lime; H0G9379FGK / Calcium Carbonate
  • [Other-IDs] NLM/ PMC2808016
  • [Keywords] NOTNLM ; aragonite / calcite / crystallization / eco-friendly paper / hydraulic activity / limestone / precipitated calcium carbonate (PCC)
  • [General-notes] NLM/ Original DateCompleted: 20100628
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61. Baran R, Bowen BP, Bouskill NJ, Brodie EL, Yannone SM, Northen TR: Metabolite identification in Synechococcus sp. PCC 7002 using untargeted stable isotope assisted metabolite profiling. Anal Chem; 2010 Nov 1;82(21):9034-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metabolite identification in Synechococcus sp. PCC 7002 using untargeted stable isotope assisted metabolite profiling.
  • Untargeted metabolite profiling has the potential to identify numerous novel metabolites; however, de novo identification of metabolites from spectral features remains a challenge.
  • PCC 7002 was performed using normal phase liquid chromatography coupled to mass spectrometry (LC-MS).
  • Analysis of acquired MS/MS spectra against spectral database records led to the identification of a number of metabolites absent not only from the reconstructed draft metabolic network of Synechococcus sp.
  • PCC 7002 but not included in databases of metabolism (MetaCyc or KEGG).

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  • (PMID = 20945921.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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62. van de Meene AM, Hohmann-Marriott MF, Vermaas WF, Roberson RW: The three-dimensional structure of the cyanobacterium Synechocystis sp. PCC 6803. Arch Microbiol; 2006 Jan;184(5):259-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The three-dimensional structure of the cyanobacterium Synechocystis sp. PCC 6803.
  • PCC 6803 we investigated the three-dimensional organization of the cytoplasm using standard transmission electron microscopy and electron tomography.
  • At some of these sites, the margins of thylakoid membranes associated closely along the external surface of rod-like structures termed thylakoid centers, which sometimes traversed nearly the entire periphery of the cell.
  • PCC 6803 using high-resolution bioimaging techniques and will allow future evaluation and comparison with gene-deletion mutants.

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  • (PMID = 16320037.001).
  • [ISSN] 0302-8933
  • [Journal-full-title] Archives of microbiology
  • [ISO-abbreviation] Arch. Microbiol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / RR-00592
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
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63. Watanabe S, Kobayashi T, Saito M, Sato M, Nimura-Matsune K, Chibazakura T, Taketani S, Nakamoto H, Yoshikawa H: Studies on the role of HtpG in the tetrapyrrole biosynthesis pathway of the cyanobacterium Synechococcus elongatus PCC 7942. Biochem Biophys Res Commun; 2007 Jan 5;352(1):36-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Studies on the role of HtpG in the tetrapyrrole biosynthesis pathway of the cyanobacterium Synechococcus elongatus PCC 7942.
  • In cyanobacterium Synechococcus elongatus PCC 7942, we observed that htpG-overexpression caused remarkable growth inhibition.

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  • (PMID = 17107658.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / HSP90 Heat-Shock Proteins; 0 / Tetrapyrroles; 134548-76-8 / HtpG protein, bacteria; EC 4.1.1.37 / Uroporphyrinogen Decarboxylase
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64. Rasch B, Dodt C, Mölle M, Born J: Sleep-stage-specific regulation of plasma catecholamine concentration. Psychoneuroendocrinology; 2007 Sep-Nov;32(8-10):884-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sleep-stage-specific regulation of plasma catecholamine concentration.
  • It is not yet clear whether blood catecholamine concentrations (as a measure of sympathetic activity in the body periphery) show a similar sleep stage-dependent decline or depend mainly on a circadian rhythm.
  • Here, we show that during sleep in humans, plasma concentrations of norepinephrine (NE) and epinephrine (E) exhibit a progressive decline associated with the stage of sleep, irrespective of the circadian time of sleep.
  • Plasma catecholamine concentrations distinctly declined in a linear fashion as sleep deepened, reaching a minimum during REM sleep both during daytime and nighttime sleep.
  • Because the changes observed here in human blood catecholamine levels closely mimic the changes in brain catecholamine activity, as well-documented in animals, we suggest that the organism's overall catecholamine activity during sleep is well represented by measures of plasma catecholamine concentrations.

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  • (PMID = 17651907.001).
  • [ISSN] 0306-4530
  • [Journal-full-title] Psychoneuroendocrinology
  • [ISO-abbreviation] Psychoneuroendocrinology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] X4W3ENH1CV / Norepinephrine; YKH834O4BH / Epinephrine
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65. Shimojima M, Tsuchiya M, Ohta H: Temperature-dependent hyper-activation of monoglucosyldiacylglycerol synthase is post-translationally regulated in Synechocystis sp. PCC 6803. FEBS Lett; 2009 Jul 21;583(14):2372-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temperature-dependent hyper-activation of monoglucosyldiacylglycerol synthase is post-translationally regulated in Synechocystis sp. PCC 6803.
  • PCC 6803 was examined by measuring MGlcDG synthase (Sll1377) activity.
  • PCC 6803, whereas the Sll1377 protein level remained unchanged, suggesting that the activity is post-translationally regulated without covalent modification of Sll1377 by soluble enzymes.

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  • (PMID = 19549521.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Glycolipids; 0 / glucosyl diacylglycerol; EC 2.4.1.- / Glucosyltransferases; EC 2.4.1.157 / 1,2-diacylglycerol 3-glucosyltransferase
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66. Gotoh E: Visualizing the dynamics of chromosome structure formation coupled with DNA replication. Chromosoma; 2007 Oct;116(5):453-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To visualize and identify the dynamics of chromosome structure formation and to elucidate the involvement of DNA replication in chromosome construction, Cy3-2'-deoxyuridine-5'-triphosphate direct-labeled active replicating DNA was observed in prematurely condensed chromosomes (PCCs) under a confocal scanning microscope utilized with drug-induced premature chromosome condensation (PCC) technique that facilitates the visualization of interphase chromatin as condensed chromosome form.
  • S-phase PCCs revealed clearly the drastic dynamics of chromosome formation that transits during S-phase from a 'cloudy nebula' to numerous numbers of 'beads on a string' and finally to 'striped arrays of banding structured chromosome' along with the progress of DNA replication.
  • Drug-induced PCC clearly provided the new insight that eukaryote DNA replication is tightly coupled with the chromosome condensation/compaction for the construction of the higher-ordered structure of the eukaryote chromosome.

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  • (PMID = 17503067.001).
  • [ISSN] 0009-5915
  • [Journal-full-title] Chromosoma
  • [ISO-abbreviation] Chromosoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 3'-deoxy-5-(cyanine dye 3)uridine 5'-trisphosphate; 0 / Carbocyanines; 0 / Chromatin; 0 / Deoxyuracil Nucleotides; G34N38R2N1 / Bromodeoxyuridine
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67. Suzuki E, Umeda K, Nihei S, Moriya K, Ohkawa H, Fujiwara S, Tsuzuki M, Nakamura Y: Role of the GlgX protein in glycogen metabolism of the cyanobacterium, Synechococcus elongatus PCC 7942. Biochim Biophys Acta; 2007 May;1770(5):763-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of the GlgX protein in glycogen metabolism of the cyanobacterium, Synechococcus elongatus PCC 7942.
  • The putative glgX gene encoding isoamylase-type debranching enzyme was isolated from the cyanobacterium, Synechococcus elongatus PCC 7942.
  • The deduced amino acid sequence indicated that the residues essential to the catalytic activity and substrate binding in bacterial and plant isoamylases and GlgX proteins were all conserved in the GlgX protein of S. elongatus PCC 7942.
  • Disruption of the glgX gene resulted in the enhanced fluctuation of glycogen content in the cells during light-dark cycles of the culture, although the effect was marginal.
  • PCC 6803, the short chains were decreased as compared to the parental mutant strain.
  • The result indicated that GlgX protein contributes to form the branching pattern of polysaccharide in S. elongatus PCC 7942.

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  • (PMID = 17321685.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA, Bacterial; 9005-79-2 / Glycogen; EC 3.2.1.68 / Isoamylase
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68. Blank A, Schmitt AM, Korpershoek E, van Nederveen F, Rudolph T, Weber N, Strebel RT, de Krijger R, Komminoth P, Perren A: SDHB loss predicts malignancy in pheochromocytomas/sympathethic paragangliomas, but not through hypoxia signalling. Endocr Relat Cancer; 2010 Dec;17(4):919-28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SDHB loss predicts malignancy in pheochromocytomas/sympathethic paragangliomas, but not through hypoxia signalling.
  • Prediction of malignant behaviour of pheochromocytomas/sympathetic paragangliomas (PCCs/PGLs) is very difficult if not impossible on a histopathological basis.
  • In a familial setting, it is well known that succinate dehydrogenase subunit B (SDHB)-associated PCC/PGL very often metastasise.
  • Recently, absence of SDHB expression as measured through immunohistochemistry was shown to be an excellent indicator of the presence of an SDH germline mutation in PCC/PGL.
  • SDHB loss is believed to lead to tumour formation by activation of hypoxia signals.
  • To clarify the potential use of SDHB immunohistochemistry as a marker of malignancy in PCC/PGL and its association with classic hypoxia signalling we examined SDHB, hypoxia inducible factor-1α (Hif-1α) and its targets CA-9 and GLUT-1 expression on protein level using immunohistochemistry on a tissue micro array on a series of familial and sporadic tumours of 115 patients.
  • SDHB protein expression was lost in the tumour tissue of 12 of 99 patients.
  • The lack of correlation of SDHB loss with classic hypoxia signals argues against the current hypoxia hypothesis in malignant PCC/PGL.
  • We suggest SDHB protein loss as a marker of adverse outcome both in sporadic and in familial PCC/PGL.
  • [MeSH-major] Adrenal Gland Neoplasms / enzymology. Pheochromocytoma / enzymology. Succinate Dehydrogenase / deficiency

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  • (PMID = 20702724.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 9007-49-2 / DNA; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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69. Zilliges Y, Kehr JC, Mikkat S, Bouchier C, de Marsac NT, Börner T, Dittmann E: An extracellular glycoprotein is implicated in cell-cell contacts in the toxic cyanobacterium Microcystis aeruginosa PCC 7806. J Bacteriol; 2008 Apr;190(8):2871-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An extracellular glycoprotein is implicated in cell-cell contacts in the toxic cyanobacterium Microcystis aeruginosa PCC 7806.
  • Differences in the cellular aggregation of M. aeruginosa PCC 7806 and a microcystin-deficient Delta mcyB mutant guided the discovery of a surface-exposed protein that shows increased abundance in PCC 7806 mutants deficient in microcystin production compared to the abundance of this protein in the wild type.
  • Mass spectrometric and immunoblot analyses revealed that the protein, designated microcystin-related protein C (MrpC), is posttranslationally glycosylated, suggesting that it may be a potential target of a putative O-glycosyltransferase of the SPINDLY family encoded downstream of the mrpC gene.
  • Immunofluorescence microscopy detected MrpC at the cell surface, suggesting an involvement of the protein in cellular interactions in strain PCC 7806.

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  • (PMID = 18281396.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adhesins, Bacterial; 0 / Glycoproteins; 0 / Microcystins
  • [Other-IDs] NLM/ PMC2293267
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70. Gao B, Sun Y, Liu Z, Meng F, Shi B, Liu Y, Xu Z: A logistic regression model for predicting malignant pheochromocytomas. J Cancer Res Clin Oncol; 2008 Jun;134(6):631-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A logistic regression model for predicting malignant pheochromocytomas.
  • It is well known that no single histological feature is diagnostic for malignant pheochromocytomas (PCCs).
  • So we developed a logistic model based on a series of clinical and pathological features to predict malignance in PCCs, and evaluated its diagnostic performance.
  • In all 130 cases with malignant or benign PCCs, 15 predictive variables were observed and entered in the logistic regression analysis in a backward stepwise way.
  • High cellularity had the highest odds ratio (OR), followed by spindle cell (>10% of tumor volume), atypical mitotic figure, periadrenal adipose tissue invasion, mitotic figures [>3/10 high-power field (HPF)], cellular monotony, capsular invasion, vascular invasion, and central or confluent tumor necrosis.
  • High cellularity, spindle cell (>10% of tumor volume) and atypical mitotic figure were selected to built a logistic model.
  • The application of the model can benefit the clinical management decision for patients with PCCs.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / diagnosis

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  • (PMID = 17999082.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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71. Huttner HB, Schellinger PD, Hartmann M, Köhrmann M, Juettler E, Wikner J, Mueller S, Meyding-Lamade U, Strobl R, Mansmann U, Schwab S, Steiner T: Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates. Stroke; 2006 Jun;37(6):1465-70
MedlinePlus Health Information. consumer health - Vitamin K.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates.
  • The aim of the present study was to compare the acute treatment strategies of OAT-associated ICH using vitamin K (VAK), fresh frozen plasma (FFP), and prothrombin complex concentrates (PCCs) with regard to hematoma growth and outcome.
  • (1) patients who received PCCs alone or in combination with FFP or VAK (n=31), (2) patients treated with FFP alone or in combination with VAK (n=18), and (3) patients who received VAK as a monotherapy (n=6).
  • Incidence and extent of hematoma growth were significantly lower in patients receiving PCCs (19%/44%) compared with FFP (33%/54%) and VAK (50%/59%).
  • However, this effect was no longer seen between PCC- and FFP-treated patients if international normalized ratio (INR) was completely reversed within 2 hours after admission.
  • Predictors for hematoma growth were an increased INR after 2 hours, whereas administration of PCCs was significantly protective in multivariate analyses.
  • CONCLUSIONS: Overall, PCC was associated with a reduced incidence and extent of hematoma growth compared with FFP and VAK.
  • [MeSH-major] Anticoagulants / adverse effects. Blood Coagulation Factors / therapeutic use. Blood Component Transfusion. Cerebral Hemorrhage / therapy. Critical Care. Hematoma / therapy. Vitamin K / therapeutic use
  • [MeSH-minor] Administration, Oral. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Plasma. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16675739.001).
  • [ISSN] 1524-4628
  • [Journal-full-title] Stroke; a journal of cerebral circulation
  • [ISO-abbreviation] Stroke
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Blood Coagulation Factors; 12001-79-5 / Vitamin K; 37224-63-8 / prothrombin complex concentrates
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72. Marbouty M, Saguez C, Cassier-Chauvat C, Chauvat F: Characterization of the FtsZ-interacting septal proteins SepF and Ftn6 in the spherical-celled cyanobacterium Synechocystis strain PCC 6803. J Bacteriol; 2009 Oct;191(19):6178-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of the FtsZ-interacting septal proteins SepF and Ftn6 in the spherical-celled cyanobacterium Synechocystis strain PCC 6803.
  • Here, we characterized SepF and Ftn6, two novel septal proteins, in the spherical-celled strain Synechocystis PCC 6803.
  • Both proteins were found to be indispensable to Synechocystis sp. strain PCC 6803.

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  • (PMID = 19648234.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Recombinant Fusion Proteins
  • [Other-IDs] NLM/ PMC2747883
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73. Koyama K, Suzuki H, Noguchi T, Akimoto S, Tsuchiya T, Mimuro M: Oxygen evolution in the thylakoid-lacking cyanobacterium Gloeobacter violaceus PCC 7421. Biochim Biophys Acta; 2008 Apr;1777(4):369-78
Hazardous Substances Data Bank. OXYGEN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxygen evolution in the thylakoid-lacking cyanobacterium Gloeobacter violaceus PCC 7421.
  • The oxygen-evolving reactions of the thylakoid-lacking cyanobacterium Gloeobacter violaceus PCC 7421 were compared with those of Synechocystis sp. PCC 6803.
  • PCC 6803, the oxygen-evolving activities were similar.
  • [MeSH-major] Cyanobacteria / metabolism. Oxygen / metabolism. Photosystem II Protein Complex / metabolism

  • Hazardous Substances Data Bank. MANGANESE, ELEMENTAL .
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  • (PMID = 18298941.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Cytochrome c Group; 0 / Photosystem II Protein Complex; 0 / PsbU protein, Synechocystis; 42Z2K6ZL8P / Manganese; 9064-80-6 / cytochrome C-550; S88TT14065 / Oxygen
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74. Fiedler B, Börner T, Wilde A: Phototaxis in the cyanobacterium Synechocystis sp. PCC 6803: role of different photoreceptors. Photochem Photobiol; 2005 Nov-Dec;81(6):1481-8
Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phototaxis in the cyanobacterium Synechocystis sp. PCC 6803: role of different photoreceptors.
  • PCC 6803 was suggested as a part of a light-stimulated signal transduction chain inhibiting movement toward blue light.
  • Analysis of mutants lacking cysteine-129 in the N-terminal chromophore binding domain indicated that this domain is also important for Cph2 function or folding of the protein.
  • PCC 6803 genome were inactivated in wild-type and cph2 knockout mutant background.

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  • (PMID = 16354116.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Cph2 protein, bacteria; 0 / Cryptochromes; 0 / Flavoproteins; 0 / Photoreceptors, Microbial; 11121-56-5 / Phytochrome
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75. Li RG, Yu X, Zhao JD: [Expression and characterization of FNRD in cyanobacterium Synechococcus sp. PCC 7002]. Wei Sheng Wu Xue Bao; 2005 Oct;45(5):716-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression and characterization of FNRD in cyanobacterium Synechococcus sp. PCC 7002].
  • PCC 7002, respectively.

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  • (PMID = 16342762.001).
  • [ISSN] 0001-6209
  • [Journal-full-title] Wei sheng wu xue bao = Acta microbiologica Sinica
  • [ISO-abbreviation] Wei Sheng Wu Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 1.18.1.2 / Ferredoxin-NADP Reductase
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76. Suzuki E, Ohkawa H, Moriya K, Matsubara T, Nagaike Y, Iwasaki I, Fujiwara S, Tsuzuki M, Nakamura Y: Carbohydrate metabolism in mutants of the cyanobacterium Synechococcus elongatus PCC 7942 defective in glycogen synthesis. Appl Environ Microbiol; 2010 May;76(10):3153-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carbohydrate metabolism in mutants of the cyanobacterium Synechococcus elongatus PCC 7942 defective in glycogen synthesis.
  • Mutants defective in each of these enzymes in Synechococcus elongatus PCC 7942 were constructed and characterized.
  • [MeSH-minor] Carbohydrates / analysis. Chlorophyll / analysis. Glucose-1-Phosphate Adenylyltransferase / genetics. Glucose-1-Phosphate Adenylyltransferase / metabolism. Glycogen Synthase / genetics. Glycogen Synthase / metabolism. Hydrogen Peroxide / pharmacology. Oxidative Stress / drug effects. Oxygen / analysis. Photosynthesis / drug effects. Phycocyanin / analysis. Sodium Chloride / pharmacology

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  • (PMID = 20363800.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbohydrates; 11016-15-2 / Phycocyanin; 1406-65-1 / Chlorophyll; 451W47IQ8X / Sodium Chloride; 9005-79-2 / Glycogen; BBX060AN9V / Hydrogen Peroxide; EC 2.4.1.11 / Glycogen Synthase; EC 2.7.7.27 / Glucose-1-Phosphate Adenylyltransferase; S88TT14065 / Oxygen; YF5Q9EJC8Y / chlorophyll a
  • [Other-IDs] NLM/ PMC2869141
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77. Huq S, Sueoka K, Narumi S, Arisaka F, Nakamoto H: Comparative biochemical characterization of two GroEL homologs from the cyanobacterium Synechococcus elongatus PCC 7942. Biosci Biotechnol Biochem; 2010;74(11):2273-80
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative biochemical characterization of two GroEL homologs from the cyanobacterium Synechococcus elongatus PCC 7942.
  • The chaperone function of cyanobacterial GroELs was examined in vitro for the first time with GroEL1 and GroEL2 of Synechococcus elongatus PCC 7942.

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  • (PMID = 21071850.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Chaperonin 60; 0 / Molecular Chaperones; EC 3.6.1.- / Adenosine Triphosphatases
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78. Cha EY, Park JS, Jeon S, Kong JS, Choi YK, Ryu JY, Park YI, Park YS: Functional characterization of the gene encoding UDP-glucose: tetrahydrobiopterin alpha-glucosyltransferase in Synechococcus sp. PCC 7942. J Microbiol; 2005 Apr;43(2):191-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional characterization of the gene encoding UDP-glucose: tetrahydrobiopterin alpha-glucosyltransferase in Synechococcus sp. PCC 7942.
  • PCC 7942 mutant resultant from a disruption in the gene encoding UDP-glucose: tetrahydrobiopterin alpha-glucosyltransferase (BGluT).
  • PCC 7942, BH4-glucoside might be involved in photosynthetic photoprotection.

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  • (PMID = 15880096.001).
  • [ISSN] 1225-8873
  • [Journal-full-title] Journal of microbiology (Seoul, Korea)
  • [ISO-abbreviation] J. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Bacterial Proteins; EC 2.4.1.- / BGluT protein, Synechococcus sp. PCC 7942; EC 2.4.1.- / Glucosyltransferases
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79. Mizusawa N, Sakata S, Sakurai I, Sato N, Wada H: Involvement of digalactosyldiacylglycerol in cellular thermotolerance in Synechocystis sp. PCC 6803. Arch Microbiol; 2009 Jul;191(7):595-601
Hazardous Substances Data Bank. HYDROXYLAMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Involvement of digalactosyldiacylglycerol in cellular thermotolerance in Synechocystis sp. PCC 6803.
  • PCC 6803 incapable of DGDG biosynthesis.
  • [MeSH-minor] Hydroxylamine / pharmacology. Mutation. Photosystem II Protein Complex / drug effects. Stress, Physiological

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  • (PMID = 19468713.001).
  • [ISSN] 1432-072X
  • [Journal-full-title] Archives of microbiology
  • [ISO-abbreviation] Arch. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Galactolipids; 0 / Photosystem II Protein Complex; 0 / digalactosyldiacylglycerol; 2FP81O2L9Z / Hydroxylamine
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80. López-Gomollón S, Hernández JA, Wolk CP, Peleato ML, Fillat MF: Expression of furA is modulated by NtcA and strongly enhanced in heterocysts of Anabaena sp. PCC 7120. Microbiology; 2007 Jan;153(Pt 1):42-50
Hazardous Substances Data Bank. IRON, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of furA is modulated by NtcA and strongly enhanced in heterocysts of Anabaena sp. PCC 7120.
  • This paper shows that in the diazotrophic cyanobacterium Anabaena sp. strain PCC 7120, levels of furA mRNA and FurA protein increase significantly in response to nitrogen deprivation, and that furA up-regulation takes place specifically in proheterocysts and mature heterocysts.

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  • (PMID = 17185533.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / RNA, Antisense; 0 / RNA, Bacterial; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / Transcription Factors; 0 / ferric uptake regulating proteins, bacterial; E1UOL152H7 / Iron
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81. Fu J, Xu X: The functional divergence of two glgP homologues in Synechocystis sp. PCC 6803. FEMS Microbiol Lett; 2006 Jul;260(2):201-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The functional divergence of two glgP homologues in Synechocystis sp. PCC 6803.
  • Glycogen phosphorylase (GlgP, EC 2.4.1.1) catalyzes the cleavage of glycogen into glucose-1-phosphate (Glc-1-P), the first step in glycogen catabolism.
  • PCC 6803, a unicellular cyanobacterium: sll1356 and slr1367.

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  • (PMID = 16842345.001).
  • [ISSN] 0378-1097
  • [Journal-full-title] FEMS microbiology letters
  • [ISO-abbreviation] FEMS Microbiol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9005-79-2 / Glycogen; EC 2.4.1.- / Glycogen Phosphorylase
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82. Maeda H, Sakuragi Y, Bryant DA, Dellapenna D: Tocopherols protect Synechocystis sp. strain PCC 6803 from lipid peroxidation. Plant Physiol; 2005 Jul;138(3):1422-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tocopherols protect Synechocystis sp. strain PCC 6803 from lipid peroxidation.
  • To test this hypothesis, tocopherol-deficient mutants of Synechocystis sp. strain PCC 6803 (slr1736 and slr1737 mutants) were challenged with a series of reactive oxygen species-generating and lipid peroxidation-inducing chemicals in combination with high-light (HL) intensity stress.
  • However, the mutants showed enhanced sensitivity to linoleic or linolenic acid treatments in combination with HL, consistent with tocopherols playing a crucial role in protecting Synechocystis sp. strain PCC 6803 cells from lipid peroxidation.
  • The tocopherol-deficient mutants were also more susceptible to HL treatment in the presence of sublethal levels of norflurazon, an inhibitor of carotenoid synthesis, suggesting carotenoids and tocopherols functionally interact or have complementary or overlapping roles in protecting Synechocystis sp. strain PCC 6803 from lipid peroxidation and HL stress.

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  • (PMID = 15965015.001).
  • [ISSN] 0032-0889
  • [Journal-full-title] Plant physiology
  • [ISO-abbreviation] Plant Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipid Peroxides; 0 / Reactive Oxygen Species; 1406-65-1 / Chlorophyll; 1406-66-2 / Tocopherols; 36-88-4 / Carotenoids
  • [Other-IDs] NLM/ PMC1176414
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83. Hampson NB: Trends in the incidence of carbon monoxide poisoning in the United States. Am J Emerg Med; 2005 Nov;23(7):838-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BASIC PROCEDURES: Published data from US poison control centers (PCCs) were used to calculate annual rates of calls regarding carbon monoxide exposures.
  • Trends in rates of carbon monoxide-related mortality, calls to PCCs, and HBO treatment were then compared.
  • MAIN FINDINGS: Contrary to the decline in carbon monoxide-related mortality from 1968 to 1998, rates of calls to PCCs significantly increased over the same period.
  • Neither rates of PCC calls nor HBO treatment changed significantly from 1992 to 2002.
  • [MeSH-minor] Hotlines / trends. Hotlines / utilization. Humans. Hyperbaric Oxygenation / trends. Hyperbaric Oxygenation / utilization. Incidence. Linear Models. Mortality / trends. Poison Control Centers / trends. Poison Control Centers / utilization. Referral and Consultation / trends. Referral and Consultation / utilization. United States / epidemiology

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  • (PMID = 16291437.001).
  • [ISSN] 0735-6757
  • [Journal-full-title] The American journal of emergency medicine
  • [ISO-abbreviation] Am J Emerg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Kondo K, Geng XX, Katayama M, Ikeuchi M: Distinct roles of CpcG1 and CpcG2 in phycobilisome assembly in the cyanobacterium Synechocystis sp. PCC 6803. Photosynth Res; 2005 Jun;84(1-3):269-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinct roles of CpcG1 and CpcG2 in phycobilisome assembly in the cyanobacterium Synechocystis sp. PCC 6803.
  • PCC 6803 by gene disruption and fractionation of phycobilisome (sub)complexes.
  • The unique phycocyanin rod-CpcG2 complex without the major allophycocyanin components was isolated from the cpcG1-disruptant.

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  • (PMID = 16049785.001).
  • [ISSN] 0166-8595
  • [Journal-full-title] Photosynthesis research
  • [ISO-abbreviation] Photosyn. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Phycobilisomes
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85. Smith MY, Dart R, Hughes A, Geller A, Senay E, Woody G, Colucci S: Clinician validation of Poison Control Center (PCC) intentional exposure cases involving prescription opioids. Am J Drug Alcohol Abuse; 2006;32(3):465-78
MedlinePlus Health Information. consumer health - Prescription Drug Abuse.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinician validation of Poison Control Center (PCC) intentional exposure cases involving prescription opioids.
  • Poison Control Center (PCC) cases involving intentional ingestion, injection or inhalation of prescription opioids are a potentially valuable source of information on the abuse and misuse of these products.
  • This study sought to validate PCC classifications of prescription opioid intentional exposure cases against clinical diagnostic criteria.
  • PCC-clinician concordance was good to excellent for Withdrawal, Abuse, and Suicide (kappa statistics: 0.73, 0.53, 0.48, respectively), but poor for Misuse and Intentional Unknown (Specific motive not known).
  • Results demonstrate the degree of compatibility between PCC and standard nosologic classifications.
  • [MeSH-major] Drug Prescriptions / statistics & numerical data. Intention. Narcotics. Poison Control Centers / statistics & numerical data. Substance-Related Disorders / epidemiology. Surveys and Questionnaires
  • [MeSH-minor] Drug Evaluation, Preclinical. Humans. Observer Variation. Substance Withdrawal Syndrome / epidemiology. Substance Withdrawal Syndrome / etiology. Suicide / statistics & numerical data

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  • MedlinePlus Health Information. consumer health - Opioid Abuse and Addiction.
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  • (PMID = 16864474.001).
  • [ISSN] 0095-2990
  • [Journal-full-title] The American journal of drug and alcohol abuse
  • [ISO-abbreviation] Am J Drug Alcohol Abuse
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Narcotics
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86. Lamadrid AI, García O, Delbos M, Voisin P, Roy L: PCC-ring induction in human lymphocytes exposed to gamma and neutron irradiation. J Radiat Res; 2007 Jan;48(1):1-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PCC-ring induction in human lymphocytes exposed to gamma and neutron irradiation.
  • Dose-effect relationships were obtained by plotting the frequencies of Premature Chromosome Condensation (PCC)-rings in PCC lymphocytes obtained by chemical induction with Calyculin A in vitro, irradiated with doses between 5 to 25 Gy.
  • For the elaboration of these curves, 9 675 PCC cells in G1 G2 and M/A stages were analysed.

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  • (PMID = 17102580.001).
  • [ISSN] 0449-3060
  • [Journal-full-title] Journal of radiation research
  • [ISO-abbreviation] J. Radiat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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87. Singh SP, Klisch M, Sinha RP, Häder DP: Effects of abiotic stressors on synthesis of the mycosporine-like amino acid shinorine in the Cyanobacterium Anabaena variabilis PCC 7937. Photochem Photobiol; 2008 Nov-Dec;84(6):1500-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of abiotic stressors on synthesis of the mycosporine-like amino acid shinorine in the Cyanobacterium Anabaena variabilis PCC 7937.
  • In the present investigation we show that the cyanobacterium Anabaena variabilis PCC 7937 produces a single mycosporine-like amino acid (MAA), shinorine (retention time = 2.3 min and absorption maximum at 334 nm) when isolated and purified by HPLC.
  • MAA synthesis was also induced by salt and ammonium in a concentration-dependent manner without UV stress in samples covered with 395 nm cutoff filters.

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  • (PMID = 18557824.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclohexanols; 0 / Cyclohexylamines; 0 / shinorine; TE7660XO1C / Glycine
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88. Backasch N, Schulz-Friedrich R, Appel J: Influences on tocopherol biosynthesis in the cyanobacterium Synechocystis sp. PCC 6803. J Plant Physiol; 2005 Jul;162(7):758-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influences on tocopherol biosynthesis in the cyanobacterium Synechocystis sp. PCC 6803.
  • To elucidate influences on the tocopherol biosynthesis in cyanobacteria, wild type and mutant cells of a putative methyltransferase in tocopherol and plastoquinone biosynthesis of Synechocystis sp.
  • PCC 6803 were grown under different conditions.

  • Hazardous Substances Data Bank. Carbon dioxide .
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  • (PMID = 16008100.001).
  • [ISSN] 0176-1617
  • [Journal-full-title] Journal of plant physiology
  • [ISO-abbreviation] J. Plant Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 1406-66-2 / Tocopherols; 142M471B3J / Carbon Dioxide; EC 2.1.1.- / Methyltransferases; IY9XDZ35W2 / Glucose; OAC30J69CN / Plastoquinone
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89. Battchikova N, Zhang P, Rudd S, Ogawa T, Aro EM: Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes of Synechocystis sp. PCC 6803. J Biol Chem; 2005 Jan 28;280(4):2587-95

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes of Synechocystis sp. PCC 6803.
  • PCC 6803, NDH-1L and NDH-1M, were studied by two-dimensional blue-native/SDS-PAGE followed by electrospray tandem mass spectrometry.
  • In addition, NdhL and a novel subunit, Ssl1690 (designated NdhO), were shown to be components of this complex.
  • All subunits mentioned above were present in the NDH-1M complex except NdhD1 and NdhF1.

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  • (PMID = 15548534.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides; 0 / Protein Subunits; EC 1.6.99.1 / NADPH Dehydrogenase
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90. Xu D, Liu X, Guo C, Zhao J: Methylglyoxal detoxification by an aldo-keto reductase in the cyanobacterium Synechococcus sp. PCC 7002. Microbiology; 2006 Jul;152(Pt 7):2013-21
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Methylglyoxal detoxification by an aldo-keto reductase in the cyanobacterium Synechococcus sp. PCC 7002.
  • An AKR gene, sakR1, was identified in the cyanobacterium Synechococcus sp. PCC 7002.
  • A mutant strain with sakR1 inactivated was sensitive to glycerol, a carbon source that can support heterotrophic growth of Synechococcus sp. PCC 7002.
  • Based on immunoblotting, SakR1 was not upregulated at an increased cellular methylglyoxal concentration.
  • A pH-dependent enzyme-activity profile suggested that SakR1 activity could be regulated by cellular pH in Synechococcus sp. PCC 7002.

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  • (PMID = 16804176.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 722KLD7415 / Pyruvaldehyde; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.1.184 / carbonyl reductase (NADPH); EC 1.1.1.21 / Aldehyde Reductase
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91. Espinosa J, Castells MA, Laichoubi KB, Contreras A: Mutations at pipX suppress lethality of PII-deficient mutants of Synechococcus elongatus PCC 7942. J Bacteriol; 2009 Aug;191(15):4863-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mutations at pipX suppress lethality of PII-deficient mutants of Synechococcus elongatus PCC 7942.
  • In Synechococcus elongatus PCC 7942, where P(II) forms complexes with the NtcA coactivator PipX, attempts to engineer P(II)-deficient strains failed in a wild-type background but were successful in pipX null mutants.

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  • (PMID = 19482921.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / PII Nitrogen Regulatory Proteins; 57657-57-5 / PIID regulatory protein, Bacteria
  • [Other-IDs] NLM/ PMC2715732
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92. Höckelmann C, Becher PG, von Reuss SH, Jüttner F: Sesquiterpenes of the geosmin-producing cyanobacterium Calothrix PCC 7507 and their toxicity to invertebrates. Z Naturforsch C; 2009 Jan-Feb;64(1-2):49-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sesquiterpenes of the geosmin-producing cyanobacterium Calothrix PCC 7507 and their toxicity to invertebrates.
  • The occurrence of sesquiterpenes was investigated with the geosmin-producing cyanobacterium Calothrix PCC 7507.
  • The essential oil obtained by vacuum destillation was studied in more detail by GC-MS methods and superposition with authentic compounds.
  • Geosmin was the dominating compound while the other sesquiterpenes were minor components.
  • Closed-loop stripping analysis revealed that most of the sesquiterpenes were found in the biomass of Calothrix, while eremophilone was mainly observed in the medium of the axenic culture.
  • The compound was not toxic for Plectus cirratus (nematoda).
  • 6,11-Epoxyisodaucane and isodihydroagarofuran exhibited no toxicity to invertebrates when applied in concentrations up to 100 microM.

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  • (PMID = 19323266.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Insecticides; 0 / Naphthols; 0 / Sesquiterpenes; MYW912WXJ4 / geosmin
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93. Sjöholm J, Oliveira P, Lindblad P: Transcription and regulation of the bidirectional hydrogenase in the cyanobacterium Nostoc sp. strain PCC 7120. Appl Environ Microbiol; 2007 Sep;73(17):5435-46
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcription and regulation of the bidirectional hydrogenase in the cyanobacterium Nostoc sp. strain PCC 7120.
  • The filamentous, heterocystous cyanobacterium Nostoc sp. strain PCC 7120 (Anabaena sp. strain PCC 7120) possesses an uptake hydrogenase and a bidirectional enzyme, the latter being capable of catalyzing both H2 production and evolution.
  • The completely sequenced genome of Nostoc sp. strain PCC 7120 reveals that the five structural genes encoding the bidirectional hydrogenase (hoxEFUYH) are separated in two clusters at a distance of approximately 8.8 kb.
  • Nevertheless, Northern blot hybridizations revealed a rather complex transcription pattern in which the different hox genes are expressed differently.
  • The transcriptions of the two clusters containing the hox genes are both induced under anaerobic conditions concomitantly with the induction of a higher level of hydrogenase activity.
  • Electrophoretic mobility shift assays with purified LexA from Nostoc sp. strain PCC 7120 demonstrated specific interactions between the transcriptional regulator and both hox promoter regions.
  • However, when LexA from Synechocystis sp. strain PCC 6803 was used, the purified protein interacted only with the promoter region of the alr0750-hoxE-hoxF operon.
  • A search of the whole Nostoc sp. strain PCC 7120 genome demonstrated the presence of 216 putative LexA binding sites in total, including recA and recF.
  • This indicates that, in addition to the bidirectional hydrogenase gene, a number of other genes, including open reading frames connected to DNA replication, recombination, and repair, may be part of the LexA regulatory network in Nostoc sp. strain PCC 7120.
  • [MeSH-minor] Anaerobiosis. Bacterial Proteins / chemistry. Bacterial Proteins / genetics. Bacterial Proteins / metabolism. Base Sequence. Culture Media. Molecular Sequence Data. Operon. Promoter Regions, Genetic. Repressor Proteins / genetics. Repressor Proteins / metabolism. Serine Endopeptidases / genetics. Serine Endopeptidases / metabolism

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  • (PMID = 17630298.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Culture Media; 0 / LexA protein, Bacteria; 0 / Repressor Proteins; EC 1.12.7.2 / Hydrogenase; EC 3.4.21.- / Serine Endopeptidases
  • [Other-IDs] NLM/ PMC2042057
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94. Rupprecht E, Gathmann S, Fuhrmann E, Schneider D: Three different DnaK proteins are functionally expressed in the cyanobacterium Synechocystis sp. PCC 6803. Microbiology; 2007 Jun;153(Pt 6):1828-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three different DnaK proteins are functionally expressed in the cyanobacterium Synechocystis sp. PCC 6803.
  • PCC 6803 in detail, genetic analyses were combined with analyses of the expression and localization patterns of the three encoded proteins.

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  • (PMID = 17526840.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / HSP70 Heat-Shock Proteins; 0 / Heat-Shock Proteins; EC 1.13.12.- / Luciferases
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95. Sato M, Yamahata H, Watanabe S, Nimura-Matsune K, Yoshikawa H: Characterization of dnaJ multigene family in the cyanobacterium Synechococcus elongatus PCC 7942. Biosci Biotechnol Biochem; 2007 Apr;71(4):1021-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of dnaJ multigene family in the cyanobacterium Synechococcus elongatus PCC 7942.
  • The genome of the cyanobacterium Synechococcus elongatus PCC 7942 contains four dnaJ homologs, which are classified into three types based on domain structure.

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  • (PMID = 17420601.001).
  • [ISSN] 0916-8451
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Algal Proteins; 0 / DNA Primers; 0 / DNA, Algal; 0 / HSP40 Heat-Shock Proteins
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96. Jain A, Verma D, Bagchi D: Catalytic and regulatory properties of sulphur metabolizing enzymes in cyanobacterium Synechococcus elongatus PCC 7942. Indian J Exp Biol; 2006 Sep;44(9):767-72
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  • [Title] Catalytic and regulatory properties of sulphur metabolizing enzymes in cyanobacterium Synechococcus elongatus PCC 7942.
  • Synechococcus elongatus PCC 7942 was able to grow with several S sources.
  • [MeSH-major] Sulfur Compounds / metabolism. Synechococcus / enzymology

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  • (PMID = 16999035.001).
  • [ISSN] 0019-5189
  • [Journal-full-title] Indian journal of experimental biology
  • [ISO-abbreviation] Indian J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Sulfur Compounds; EC 1.8.- / Oxidoreductases Acting on Sulfur Group Donors; EC 2.5.1.47 / Cysteine Synthase; EC 2.7.7.4 / Sulfate Adenylyltransferase; EC 2.8.1.- / Sulfurtransferases; EC 2.8.1.5 / thiosulfate-dithiol sulfurtransferase; EC 4.4.1.1 / Cystathionine gamma-Lyase
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97. Lee BD, Apel WA, Walton MR: Calcium carbonate formation by Synechococcus sp. strain PCC 8806 and Synechococcus sp. strain PCC 8807. Bioresour Technol; 2006 Dec;97(18):2427-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calcium carbonate formation by Synechococcus sp. strain PCC 8806 and Synechococcus sp. strain PCC 8807.
  • Synechococcus sp. strain PCC 8806 and Synechococcus sp. strain PCC 8807 were tested in microcosm experiments for their ability to calcify when exposed to a fixed calcium concentration of 3.4 mM and dissolved inorganic carbon concentrations of 0.5, 1.25 and 2.5 mM.
  • Synechococcus sp. strain PCC 8806 removed calcium continuously over the duration of the experiment producing approximately 18.6 mg of solid phase calcium.
  • Calcium removal occurred over a two-day time period when Synechococcus sp. strain PCC 8807 was tested and only 8.9 mg of solid phase calcium was produced.
  • Creation of an alkaline growth environment catalyzed by the physiology of the cyanobacteria appeared to be the primary factor responsible for CaCO3 precipitation in these experiments.
  • [MeSH-minor] Bicarbonates / pharmacology. Calcium / metabolism. Carbon Dioxide / metabolism. Chemical Precipitation. Hydrogen-Ion Concentration

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  • (PMID = 16289626.001).
  • [ISSN] 0960-8524
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bicarbonates; 142M471B3J / Carbon Dioxide; H0G9379FGK / Calcium Carbonate; SY7Q814VUP / Calcium
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98. Sato M, Nimura-Matsune K, Watanabe S, Chibazakura T, Yoshikawa H: Expression analysis of multiple dnaK genes in the cyanobacterium Synechococcus elongatus PCC 7942. J Bacteriol; 2007 May;189(10):3751-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression analysis of multiple dnaK genes in the cyanobacterium Synechococcus elongatus PCC 7942.
  • We analyzed the stress responses of three dnaK homologues (dnaK1, dnaK2, and dnaK3) in the cyanobacterium Synechococcus elongatus PCC 7942.

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  • (PMID = 17351044.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DnaK3 protein, Synechococcus; 0 / HSP70 Heat-Shock Proteins; 0 / Membrane Proteins; 0 / RNA, Bacterial
  • [Other-IDs] NLM/ PMC1913318
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99. Leganés F, Forchhammer K, Fernández-Piñas F: Role of calcium in acclimation of the cyanobacterium Synechococcus elongatus PCC 7942 to nitrogen starvation. Microbiology; 2009 Jan;155(Pt 1):25-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of calcium in acclimation of the cyanobacterium Synechococcus elongatus PCC 7942 to nitrogen starvation.
  • A Ca2+ signal is required for the process of heterocyst differentiation in the filamentous diazotrophic cyanobacterium Anabaena sp. PCC 7120.
  • This paper presents evidence that a transient increase in intracellular free Ca2+ is also involved in acclimation to nitrogen starvation in the unicellular non-diazotrophic cyanobacterium Synechococcus elongatus PCC 7942.
  • Taken together, the results presented here strongly suggest an involvement of a defined Ca2+ transient in acclimation of S. elongatus to nitrogen starvation through NtcA-dependent regulation.
  • [MeSH-minor] Aequorin / metabolism. Apoproteins / metabolism. Bacterial Proteins / genetics. Bacterial Proteins / metabolism. Calcium-Binding Proteins / metabolism. Culture Media. Heat-Shock Response. Ketoglutaric Acids / metabolism. Mutation. PII Nitrogen Regulatory Proteins / genetics. PII Nitrogen Regulatory Proteins / metabolism. Recombinant Proteins / metabolism. Sulfur / metabolism. Transcription Factors / metabolism

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  • (PMID = 19118343.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apoproteins; 0 / Bacterial Proteins; 0 / Calcium-Binding Proteins; 0 / Culture Media; 0 / Ketoglutaric Acids; 0 / PII Nitrogen Regulatory Proteins; 0 / Recombinant Proteins; 0 / Transcription Factors; 0 / apoaequorin; 328-50-7 / alpha-ketoglutaric acid; 50934-79-7 / Aequorin; 70FD1KFU70 / Sulfur; N762921K75 / Nitrogen; SY7Q814VUP / Calcium
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100. Shimada Y, Tsuchiya T, Akimoto S, Tomo T, Fukuya M, Tanaka K, Mimuro M: Spectral properties of the CP43-deletion mutant of Synechocystis sp. PCC 6803. Photosynth Res; 2008 Oct-Dec;98(1-3):303-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spectral properties of the CP43-deletion mutant of Synechocystis sp. PCC 6803.
  • Spectral properties, particularly fluorescence spectra and their time-dependent behavior, were investigated for a mutant of the cyanobacterium Synechocystis sp.
  • PCC 6803 lacking the 43 kDa chlorophyll-protein (CP43, PsbC).
  • [MeSH-major] Bacterial Proteins / genetics. Photosynthetic Reaction Center Complex Proteins / genetics. Photosystem II Protein Complex / physiology. Synechocystis / physiology

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  • (PMID = 18777104.001).
  • [ISSN] 0166-8595
  • [Journal-full-title] Photosynthesis research
  • [ISO-abbreviation] Photosyn. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Photosynthetic Reaction Center Complex Proteins; 0 / Photosystem II Protein Complex; 0 / photosystem II, chlorophyll binding protein, CP-43
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