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6. Cardoso CC, Bornstein SR, Hornsby PJ: Optimizing orthotopic cell transplantation in the mouse adrenal gland. Cell Transplant; 2010;19(5):565-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optimizing orthotopic cell transplantation in the mouse adrenal gland.
  • In published studies of orthotopic transplantation in the mouse adrenal gland, human neuroblastoma cells have been shown to invade and occupy the adrenal, but in these investigations a true orthotopic model was not established.
  • Here we show an orthotopic model in which transplanted cells are retained within the adrenal gland by formation of a fibrin clot.
  • To establish an appropriate technique, we used brightly fluorescent 10 microm polystyrene microspheres injected into the mouse adrenal gland.
  • In the absence of fibrinogen/thrombin for clot formation, much of the injected material was extruded to the outside of the gland.
  • When the microspheres were injected in a fibrinogen/thrombin mixture, fluorescence was confined to the adrenal gland.
  • As a model neoplastic cell originating from the cortex of the gland, we used a tumorigenic bovine adrenocortical cell line.
  • As a model neoplastic cell of neural crest origin, we used SK-N-AS human neuroblastoma cells.
  • Orthotopic transplantation of 3 x 10(5) cells resulted in extensive invasion and destruction of the gland by 26 days.
  • In summary, the present orthotopic model for intra-adrenal cell transplantation is valuable for investigation of growth of neoplastic cells of both cortical and medullary origin and should be useful for future studies of cortex-medulla interactions.

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  • (PMID = 20525431.001).
  • [ISSN] 1555-3892
  • [Journal-full-title] Cell transplantation
  • [ISO-abbreviation] Cell Transplant
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / AG012287-14; United States / NIA NIH HHS / AG / P01 AG020752-020006; United States / NIA NIH HHS / AG / AG020752-020006; United States / NIA NIH HHS / AG / P01 AG020752; United States / NIA NIH HHS / AG / R37 AG012287-14; United States / NIA NIH HHS / AG / R37 AG012287
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9001-31-4 / Fibrin; 9001-32-5 / Fibrinogen; EC 3.4.21.5 / Thrombin
  • [Other-IDs] NLM/ NIHMS246503; NLM/ PMC3735364
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7. Otmani N, Khattab M: Metastatic neuroblastoma to the mandible in a 3-year-old boy: a case report. Med Oral Patol Oral Cir Bucal; 2007 May;12(3):E201-4
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  • [Title] Metastatic neuroblastoma to the mandible in a 3-year-old boy: a case report.
  • Although neuroblastoma is a relatively common malignancy of childhood and its dissemination to distant organs is often seen, metastasis to the mandible is rare.
  • A 3-year-old boy which a mandibular soft tissue mass was the initial presenting symptom of disseminated neuroblastoma is reported.
  • The results of biopsy were inconclusive and the differential diagnosis from the imaging studies included lymphoma, soft tissue sarcoma, and osteosarcoma.
  • A metastatic work-up disclosed neuroblastoma of the adrenal gland origin with osseous and bone marrow metastases.
  • This case illustrates that neuroblastoma at a young age, with bone metastases and bone marrow involvement are predictive of the poor outcome of the disease.
  • Therefore, detecting early stage metastasis is one of the essential factors for improving treatment of neuroblastoma patients.
  • [MeSH-major] Mandibular Neoplasms / secondary. Neuroblastoma / secondary
  • [MeSH-minor] Adrenal Gland Neoplasms / pathology. Child, Preschool. Fatal Outcome. Humans. Male. Neoplasm Staging / standards

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  • (PMID = 17468714.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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8. Meersman A, Wojciechowski M, Vaneerdeweg W, Jorens P, Michiels E, Ramet J: Acute retroperitoneal hemorrhage and shock as presenting signs of neuroblastoma in an infant. Pediatr Emerg Care; 2008 Jan;24(1):37-8
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  • [Title] Acute retroperitoneal hemorrhage and shock as presenting signs of neuroblastoma in an infant.
  • Adrenal hemorrhage after the neonatal period is rare.
  • Spontaneous bleeding within an adrenal neuroblastoma has been described, but acute massive hemorrhage is exceptional.
  • We describe a case of neuroblastoma of the adrenal gland presenting with acute life-threatening abdominal hemorrhage.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemoperitoneum / diagnosis. Neuroblastoma / diagnosis. Shock, Hemorrhagic / diagnosis
  • [MeSH-minor] Acute Disease. Diagnosis, Differential. Emergency Service, Hospital. Follow-Up Studies. Humans. Infant. Laparotomy / methods. Lymphatic Metastasis. Male. Risk Assessment. Rupture, Spontaneous. Tomography, X-Ray Computed. Treatment Outcome. Wilms Tumor / diagnosis

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  • (PMID = 18212608.001).
  • [ISSN] 1535-1815
  • [Journal-full-title] Pediatric emergency care
  • [ISO-abbreviation] Pediatr Emerg Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Genc H, Haciyanli M, Haciyanli SG, Gelal F, Avci Uçarsoy A, Dag F: An adult adrenal neuroblastoma: a case report. Acta Chir Belg; 2005 Nov-Dec;105(6):673-6
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  • [Title] An adult adrenal neuroblastoma: a case report.
  • Neuroblastoma of the adrenal gland is an extremely rare tumour in adulthood although it is one of the most common malignancies in childhood.
  • In this report, we present a 52-year-old man who had a left adrenal mass on preoperative imaging.
  • The histopathological examination of the specimen revealed the diagnosis of neuroblastoma.
  • He had no metastatic disease at the time of diagnosis and received chemotherapy after the operation.
  • Although neuroblastoma of adrenal gland is rare in adulthood, it should be considered in the differential diagnosis for patients with adrenal masses.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis

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  • (PMID = 16438086.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 5001-33-2 / Metanephrine; 55-10-7 / Vanilmandelic Acid
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10. Pagès PM, Dufour C, Fasola S, Michon J, Boutard P, Gentet JC, Hartmann O: Bilateral adrenal neuroblastoma. Pediatr Blood Cancer; 2009 Feb;52(2):196-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral adrenal neuroblastoma.
  • BACKGROUND: Bilateral adrenal neuroblastoma is extremely rare.
  • PROCEDURES: We retrospectively identified and reviewed 15 cases of bilateral adrenal neuroblastoma, treated between 1988 and 2004, by the French Society of Pediatric Oncology.
  • RESULTS: Median age at diagnosis was 4 months in our cohort whereas it was 3 months in the literature.
  • Ten out of 15 patients in our cohort and 18/39 cases in the literature were classified as stage 4S according to the International Neuroblastoma Staging System (INSS).
  • The incidence of stage 4S was significantly higher than that described in other neuroblastoma cohorts (P = 10(-4)).
  • In our series, bilateral neuroblastoma was neither associated with familial cases nor with any risk factors.
  • CONCLUSIONS: The majority of bilateral neuroblastoma carry a favorable prognosis.
  • Exceptional cases exhibiting risk factors, such as amplified MYCN, are comparable to high-risk unilateral neuroblastoma cases with the same poor prognostic features.
  • The therapeutic strategy could be similar to that used against unilateral neuroblastoma, except for surgery.
  • However, the low incidence of relapse and the risk of adrenal failure if radical surgery is performed, argue against an aggressive surgical approach.
  • [MeSH-major] Adrenal Gland Neoplasms / epidemiology. Neuroblastoma / epidemiology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18951434.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins
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11. Janjanin N, Dumic M, Skrabic V, Kusec V, Grubic Z, Spehar Uroic A: Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family. Horm Res; 2007;67(3):111-6
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  • [Title] Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family.
  • CASE REPORT: We present 5 patients with congenital adrenal hyperplasia (CAH) due to 21-OHD belonging to the 3 generations of the same family (grandmother, parents and their 2 children).
  • The probands' mother, besides the nonclassical 21-OHD, also had neuroblastoma of the adrenal gland.
  • The occurrence of neuroblastoma with 21-OHD may support the hypothesis that an impairment in the synthesis and secretion of glucocorticoids may play role in the development and functioning of the adrenal medulla.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Hyperplasia, Congenital / diagnosis. Neuroblastoma / complications. Steroid 21-Hydroxylase


12. Raveenthiran V, Cenita S, Viswanathan P: Stabler's sign revisited in a spontaneously ruptured neuroblastoma of the newborn. Am J Perinatol; 2008 Jan;25(1):17-20
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  • [Title] Stabler's sign revisited in a spontaneously ruptured neuroblastoma of the newborn.
  • Spontaneous adrenal hemorrhage is the most common cause of nontraumatic parietal ecchymosis sign in neonates.
  • We report the sign for the first time in a case of spontaneously ruptured adrenal neuroblastoma of newborn.
  • Perinatal physicians need to be aware of this unusual presentation of neonatal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Ecchymosis / etiology. Neuroblastoma / pathology

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  • (PMID = 18050035.001).
  • [ISSN] 0735-1631
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Pederiva F, Andres A, Sastre A, Alves J, Martinez L, Tovar JA: Bilateral adrenal neuroblastoma is different. Eur J Pediatr Surg; 2007 Dec;17(6):393-6
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  • [Title] Bilateral adrenal neuroblastoma is different.
  • BACKGROUND/AIMS: Bilateral adrenal neuroblastoma is rare and can be due to multifocal primary or contralateral metastasis.
  • The present study examines the clinical, biological and therapeutic features of bilateral adrenal neuroblastoma.
  • CONCLUSIONS: Bilateral adrenal neuroblastomas fit neither into stage 4 s nor into stage 4.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Adrenalectomy / methods. Antineoplastic Agents / therapeutic use. Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Male. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 18072022.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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4. Johnston DL, Sweeney B, Halton JM: Bilateral adrenal neuroblastoma: stage V disease. J Pediatr Hematol Oncol; 2007 Sep;29(9):652-5
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  • [Title] Bilateral adrenal neuroblastoma: stage V disease.
  • Neuroblastoma frequently arises from the adrenal gland and has rarely been reported to arise synchronously in both adrenal glands.
  • The majority of reports of bilateral adrenal neuroblastoma are in children under the age of 1 year.
  • We present a case of bilateral adrenal neuroblastoma in an 8-year-old child.
  • This is the first report of bilateral disease in a child over the age of 1 year with stage IV neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Child. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging

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  • [CommentIn] J Pediatr Hematol Oncol. 2008 May;30(5):408-9 [18458582.001]
  • (PMID = 17805045.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Boyd DT, Hayeri MR, Kadom N: Parotid metastasis from adrenal neuroblastoma. Pediatr Radiol; 2010 Dec;40 Suppl 1:S113-5
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  • [Title] Parotid metastasis from adrenal neuroblastoma.
  • In contrast, salivary gland tumors are uncommon in children, accounting for only 1% of all pediatric neoplasms.
  • We present a case of a parotid metastasis from a neuroblastoma with in-depth description and discussion of its ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) appearances.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Diagnostic Imaging / methods. Neuroblastoma / diagnosis. Neuroblastoma / secondary. Parotid Neoplasms / diagnosis. Parotid Neoplasms / secondary


16. Chacko J, Karl S, Sen S, Eapen A, Mathai J: Bilateral cystic adrenal neuroblastoma with cystic metastasis in the liver. J Pediatr Surg; 2007 Aug;42(8):E11-3
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  • [Title] Bilateral cystic adrenal neuroblastoma with cystic metastasis in the liver.
  • Ultrasound and computerized tomography showed a large cystic lesion in the right adrenal, small cysts in the left adrenal, and multiple cystic liver metastases.
  • The right adrenal cyst, on excision, turned out to be a cystic neuroblastoma with hemorrhage.
  • On follow-up, the cysts in the left adrenal and the liver metastases are regressing.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Liver Neoplasms / diagnosis. Neuroblastoma / diagnosis

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  • (PMID = 17706480.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Nakao K, Maitani Y: Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma. Int J Oncol; 2010 Sep;37(3):695-705
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  • [Title] Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma.
  • Adrenal neuroblastoma and pheochromocytoma have the same embryonic origin from neural crest cells and mainly arise from the adrenal medulla.
  • Recently, transgenic mice exhibiting tumors in the bilateral adrenal medulla by the expression of SV40 T-antigen were developed.
  • In this study, we investigated mRNA expression in adrenal tumors of transgenic mice and compared them with human pheochromocytoma by DNA microarray analysis.
  • To compare mouse adrenal tumors and human pheochromacytoma, we found that the expressions of noradrenergic neuron-related genes, including dopa decarboxylase, phenylethanolamine-N-methyltransferase and chromogranin B, were up-regulated in humans but not in mice; however, the expression of neuroblastoma-related genes, including Mycn, paired-like homeobox 2b, gamma-aminobutyric acid A receptor beta3 subunit, islet 1 and kinesin family member 1A, was up-regulated in both species.
  • From the gene expression profiles, the characterization of mouse adrenal tumor, may be similar to that of human adrenal neuroblastoma rather than pheochromacytomas.
  • This mouse model would be a useful tool for the development of anti-cancer drugs and for understanding the etiology of adrenal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Pheochromocytoma / genetics


18. Schalk E, Mohren M, Koenigsmann M, Buhtz P, Franke A, Jentsch-Ullrich K: Metastatic adrenal neuroblastoma in an adult. Onkologie; 2005 Jun;28(6-7):353-5
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  • [Title] Metastatic adrenal neuroblastoma in an adult.
  • BACKGROUND: Neuroblastoma (NB) is a common malignancy in children, but rarely occurs in adults.
  • In adults, abdomen/retroperitoneum are the primary sites and in children the adrenal gland.
  • Tumour resection revealed adrenal NB grade III.
  • Chemotherapy according to the paediatric German Neuroblastoma Trial (NB97) was started.
  • The patient died 9 months after diagnosis.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neuroblastoma / pathology. Neuroblastoma / secondary

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  • (PMID = 15933424.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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19. Messina M, Di Maggio G, Garzi A, Molinaro F, Amato G, Ferrara F: [Neonatal neuroblastoma and prenatal diagnosis]. Minerva Pediatr; 2009 Jun;61(3):349-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neonatal neuroblastoma and prenatal diagnosis].
  • [Transliterated title] Neuroblastoma neonatale e diagnosi pre-natale.
  • The authors present a case of neonatal neuroblastoma diagnosed in prenatal age and managed with a multidisciplinary approach.
  • The echographic morphological prenatal diagnosis showed an abdominal mass of 3x2 cm located on the upper side of the kidney, which was not apparently involved.
  • Postnatal ultrasound evaluations confirmed that diagnosis.
  • These exams confirmed the presence of a mass, probably due to a neuroblastoma.
  • The histological examination confirmed the diagnosis of neuroblastoma Stage I without medullary involvement.
  • In conclusion, the effectiveness of a multidisciplinary approach of neonatal neuroblastoma is higher in the early diagnosis and in an accurate staging of the disease, which is fundamental for the favourable prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Neuroblastoma / diagnosis. Prenatal Diagnosis
  • [MeSH-minor] 3-Iodobenzylguanidine. Diagnosis, Differential. Humans. Infant, Newborn. Magnetic Resonance Spectroscopy. Neoplasm Staging. Radioisotope Renography / methods. Radiopharmaceuticals. Treatment Outcome. Ultrasonography, Prenatal


20. Köksal Y, Varan A, Kale G, Tanyel FC, Büyükpamukçu M: Bilateral adrenal cystic neuroblastoma with hepatic and splenic involvement in a newborn. J Pediatr Hematol Oncol; 2005 Dec;27(12):670-1
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  • [Title] Bilateral adrenal cystic neuroblastoma with hepatic and splenic involvement in a newborn.
  • Bilateral cystic adrenal neuroblastoma is an unusual variant of neuroblastoma, and only two cases have been reported in the neonatal period until now.
  • The authors describe a newborn with splenic and hepatic involvement of bilateral adrenal cystic neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / congenital. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / secondary. Neuroblastoma / congenital. Splenic Neoplasms / secondary

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  • (PMID = 16344674.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Wang J, Pei G, Yan J, Zhang G: Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. J Pediatr Hematol Oncol; 2009 Dec;31(12):983-4
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  • [Title] Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer.
  • A 4-month girl presenting with a giant mass in left adrenal region and multiple hepatic nodules was hospitalized.
  • On the basis of computed tomography, ultrasound and epidemiology we preferred the diagnosis of a left adrenal neuroblastoma accompanied with multiple hepatic metastases preoperatively.
  • But postoperative diagnosis was hemangiomatosis characterized by synchronous presence of a giant splenic hemangioma and multiple hepatic hemangiomas.
  • We think that it is deservedly reported because of not only its rarity but also pitfalls of preoperative differential diagnosis and management principle.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemangioma / pathology. Liver Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neuroblastoma / diagnosis. Splenic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Ultrasonography


22. Berrebi D, Lebras MN, Belarbi N, Couturier J, Fattet S, Faye A, Peuchmaur M, de Lagausie P: Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome. J Pediatr Surg; 2006 Jan;41(1):e11-4
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  • [Title] Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome.
  • Such association led quickly to the diagnosis of FA.
  • At age of 11 months, she developed simultaneously a renal tumor in a horseshoe kidney and bilateral adrenal tumors.
  • The left adrenal mass was removed, and partial nephrectomy was performed.
  • Histological analysis concluded to adrenal neuroblastoma and nephroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Fanconi Anemia / complications. Kidney Neoplasms / pathology. Neuroblastoma / pathology. Wilms Tumor / pathology


23. Patterson AR, Barker CS, Loukota RA, Spencer J: Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma. Int J Oral Maxillofac Surg; 2009 Feb;38(2):196-8
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  • [Title] Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma.
  • Neuroblastoma, ganglioneuroblastoma and ganglioneuroma are neuroblastic tumours derived from primordial neural crest tissue.
  • The authors report a rare presentation of a ganglioneuroma of the mandible arising from a metastasis of an adrenal neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Ganglioneuroblastoma / pathology. Ganglioneuroma / radiography. Mandibular Neoplasms / secondary. Neoplasms, Neuroepithelial / secondary. Neuroblastoma / secondary

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  • (PMID = 19019630.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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24. Tatekawa Y, Muraji T, Nishijima E, Yoshida M, Tsugawa C: Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report. J Pediatr Surg; 2006 Feb;41(2):443-5
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  • [Title] Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report.
  • Screening abdominal ultrasonography showed a 6-cm-sized mass in the left adrenal gland.
  • Metaiodobenzyl guanidine I 123 scintigram, abdominal computed tomography, and abdominal magnetic resonance imaging revealed only left adrenal tumor with no metastasis.
  • Left adrenalectomy was performed transperitoneally, and histopathological diagnosis was an adrenal composite pheochromocytoma associated with neuroblastoma.
  • Immunoreactivity for vimentin was positive in pheochromocytoma, which was negative in neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neuroblastoma / pathology. Pheochromocytoma / pathology


25. Alsultan A, Lovell MA, Hayes KL, Allshouse MJ, Garrington TP: Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. Pediatr Blood Cancer; 2008 Nov;51(5):695-8
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  • [Title] Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome.
  • We present the case of an infant with BWS who has hypomethylation of LIT1 gene in the 11p15.5 chromosomal region and at 6 months of age presented with simultaneous occurrence of neuroblastoma arising from the left adrenal gland and a right adrenocortical tumor.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenal Gland Neoplasms / complications. Beckwith-Wiedemann Syndrome / complications. Neoplasms, Multiple Primary / complications. Neuroblastoma / complications


26. Rabah R, Weber R, Serhatkulu GK, Cao A, Dai H, Pandya A, Naik R, Auner G, Poulik J, Klein M: Diagnosis of neuroblastoma and ganglioneuroma using Raman spectroscopy. J Pediatr Surg; 2008 Jan;43(1):171-6
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  • [Title] Diagnosis of neuroblastoma and ganglioneuroma using Raman spectroscopy.
  • BACKGROUND: Raman spectroscopy has proven to be useful in studying premalignant and malignant lesions in adults.
  • This is the first report to evaluate Raman spectroscopy in the diagnosis and classification of neuroblastoma in children.
  • METHODS: A biopsy or resection of fresh tissue samples from normal adrenal glands, neuroblastomas, ganglioneuromas, nerve sheath tumors, and pheochromocytoma at our hospital were equally divided between routine histology and spectroscopic studies.
  • RESULTS: We collected 698 spectra from 16 neuroblastomas, 5 ganglioneuromas, 3 normal adrenal glands, 6 nerve sheath tumors, and 1 pheochromocytoma.
  • Raman spectroscopy differentiated between normal adrenal gland, and neuroblastoma and ganglioneuroma with 100% sensitivity and 100% specificity.
  • It was also able to differentiate neuroblastoma from nerve sheath tumors and pheochromocytoma with high sensitivity and specificity.
  • CONCLUSION: This technique can differentiate neuroblastoma from ganglioneuroma and other tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Ganglioneuroma / diagnosis. Neuroblastoma / diagnosis. Pheochromocytoma / diagnosis. Spectrum Analysis, Raman / methods
  • [MeSH-minor] Biopsy, Needle. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Male. Sampling Studies. Sensitivity and Specificity. Tissue Embedding


27. Auber F, Larroquet M, Bonnard A, Boudjemaa S, Landman-Parker J, Ducou Le Pointe H, Boccon-Gibod L, Lefebvre G, Uzan S, Hélardot P, Audry G: [Prenatal ultrasound diagnosis of neuroblastoma]. Gynecol Obstet Fertil; 2005 Apr;33(4):228-31
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  • [Title] [Prenatal ultrasound diagnosis of neuroblastoma].
  • With the progress of foetal ultrasonography, diagnosis of foetal tumors can be made before birth.
  • We report five cases of prenatally detected neuroblastoma of the adrenal glands.
  • Diagnosis was made during the third trimester in all cases.
  • In each setting the tumor was a stage I neuroblastoma according to the Evans classification.
  • [MeSH-major] Adrenal Gland Neoplasms / ultrasonography. Fetal Diseases / ultrasonography. Neuroblastoma / ultrasonography. Ultrasonography, Prenatal


28. Nuchtern JG: Perinatal neuroblastoma. Semin Pediatr Surg; 2006 Feb;15(1):10-6
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  • [Title] Perinatal neuroblastoma.
  • Over the past two decades, routine prenatal ultrasound has significantly increased the rate of diagnosis of fetal neuroblastoma.
  • More than 90% of these tumors arise in the adrenal gland, suggesting a link between perinatal tumors and the nodular collections of neuroblasts that are part of normal adrenal development.
  • In fact, there is compelling evidence that the cystic variant of perinatal neuroblastoma is caused by a perturbation of the involution program of these neuroblastic nodules.
  • The ultimate goal of such studies is to define an ultra-low-risk group of neuroblastoma patients who do not require invasive procedures or chemotherapy to achieve an excellent outcome.
  • [MeSH-major] Fetal Diseases / diagnosis. Fetal Diseases / physiopathology. Neuroblastoma / diagnosis. Neuroblastoma / physiopathology


29. Gambini JP, López Lerena JJ, Quagliata A, Hermida JC, Heuguerot C, Alonso O: 99mTc-HYNIC octreotide in neuroblastoma. Ann Nucl Med; 2008 Nov;22(9):817-9
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  • [Title] 99mTc-HYNIC octreotide in neuroblastoma.
  • Disease status assessment of neuroblastoma patients requires computed tomography (or magnetic resonance imaging), bone scan, metaiodobenzylguanidine (MIBG) scan, bone marrow tests, and urine catecholamine measurements.
  • An 8-year-old boy already diagnosed with stage-IV neuroblastoma received chemotherapy.
  • Therefore, 99mTc-HYNIC-octreotide may be a promising radiopharmaceutical for the evaluation of neuroblastoma patients.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Gland Neoplasms / radionuclide imaging. Neuroblastoma / radionuclide imaging. Octreotide / analogs & derivatives. Organotechnetium Compounds

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  • (PMID = 19039561.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; 35MRW7B4AD / 3-Iodobenzylguanidine; RWM8CCW8GP / Octreotide
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30. Avanzini S, Conte M, Granata C, Zamorani EM, Sementa AR, Garaventa A, Buffa P, Sorrentino S: Life-threatening bilateral adrenal cystic neuroblastoma in an infant. J Pediatr Hematol Oncol; 2009 Dec;31(12):963-4
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  • [Title] Life-threatening bilateral adrenal cystic neuroblastoma in an infant.
  • A case of neonatal bilateral adrenal mass causing severe respiratory distress and requiring an emergency debulking surgical procedure is reported.
  • Histopathology revealed a cystic neuroblastoma stroma poor, poorly differentiated, without MYCN amplification and 1p deletion.
  • Both adrenal masses and hepatic nodules showed progressive decrease in size, till complete disappearance.
  • The authors encourage a multidisciplinary approach to develop the best patient-related strategy for cystic neuroblastoma, thus reducing complications rate.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Cysts / pathology. Neuroblastoma / pathology. Respiratory Distress Syndrome, Newborn / diagnosis

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  • (PMID = 19887960.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Iwanaka T, Kawashima H, Uchida H: The laparoscopic approach of neuroblastoma. Semin Pediatr Surg; 2007 Nov;16(4):259-65
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  • [Title] The laparoscopic approach of neuroblastoma.
  • Neuroblastoma is one of the most common solid tumors, and the biopsy and excision of this tumor are often required as part of a planned multimodal treatment.
  • In 1995, Holcomb and coworkers first reported endosurgical procedures for the diagnosis and treatment of pediatric malignancies; however, the usefulness of laparoscopic procedures for abdominal neuroblastoma is still unclear.
  • Twenty-five laparoscopic biopsies for advanced abdominal neuroblastoma and nine laparoscopic excisions for localized abdominal neuroblastoma performed at Saitama Children's Medical Center were evaluated.
  • Also, the blood loss of laparoscopic excision of localized neuroblastoma was significantly little compared with that of open excision.
  • Precise indications of laparoscopic procedure for the diagnosis and treatment of abdominal neuroblastoma provide better prognosis and quality of life for infants and children.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Neuroblastoma / surgery
  • [MeSH-minor] Algorithms. Child. Child, Preschool. Female. Hemostasis, Surgical. Humans. Infant. Laparoscopy. Lymph Node Excision. Male. Neoplasm Seeding. Tomography, X-Ray Computed

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  • (PMID = 17933668.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Rossbach HC, Baschinsky D, Wynn T, Obzut D, Sutcliffe M, Tebbi C: Composite adrenal anaplastic neuroblastoma and virilizing adrenocortical tumor with germline TP53 R248W mutation. Pediatr Blood Cancer; 2008 Mar;50(3):681-3
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  • [Title] Composite adrenal anaplastic neuroblastoma and virilizing adrenocortical tumor with germline TP53 R248W mutation.
  • Such tumors in adrenal glands are usually of neuroendocrine-neural type and occur mostly in adults.
  • We report a patient with composite neuroblastoma (NB), adrenocortical tumor (ACT), and Li-Fraumeni syndrome (LFS) with germline TP53 R248W mutation.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenal Gland Neoplasms / pathology. Adrenocortical Adenoma / pathology. Genes, p53. Germ-Line Mutation. Li-Fraumeni Syndrome / genetics. Mutation, Missense. Neoplasms, Multiple Primary / pathology. Neuroblastoma / pathology. Point Mutation. Virilism / etiology

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17427234.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Leclair MD, de Lagausie P, Becmeur F, Varlet F, Thomas C, Valla JS, Petit T, Philippe-Chomette P, Mure PY, Sarnacki S, Michon J, Heloury Y: Laparoscopic resection of abdominal neuroblastoma. Ann Surg Oncol; 2008 Jan;15(1):117-24
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  • [Title] Laparoscopic resection of abdominal neuroblastoma.
  • BACKGROUND: Since indications for laparoscopic adrenalectomy have progressively expanded to pediatric surgery, preliminary reports have studied the laparoscopic approach for abdominal neuroblastoma (NB).
  • Primary site of the tumor was the adrenal gland in 41 cases and retroperitoneal space in 4.
  • CONCLUSION: Laparoscopic resection of abdominal primary allows effective local control of the disease in a wide range of clinical situations of neuroblastoma, with an acceptable morbidity.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Laparoscopy. Neuroblastoma / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Humans. Infant. Infant, Newborn. Male. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17926102.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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34. Quackenbush KE, Luna-Fineman S, Magee JF, Gundogan M, Golobi M, Irie T, Fernandez CV: Neuroblastoma involvement of the falx cerebri. Pediatr Blood Cancer; 2009 Dec 15;53(7):1337-9
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  • [Title] Neuroblastoma involvement of the falx cerebri.
  • Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare.
  • The falx is derived from the neural crest and thus may be a location for primary neuroblastoma.
  • Management of neuroblastoma in this location is potentially challenging.
  • We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dura Mater / pathology. Meningeal Neoplasms / secondary. Neuroblastoma / secondary
  • [MeSH-minor] Adrenalectomy. Carboplatin / administration & dosage. Cell Lineage. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Infant. Infant, Newborn. Male. Microphthalmia-Associated Transcription Factor / genetics. Neoplasm Staging. Neural Crest. Pulmonary Veins / abnormalities. Remission Induction. Skin Neoplasms / drug therapy. Skin Neoplasms / secondary. Waardenburg Syndrome / complications. Waardenburg Syndrome / genetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19821537.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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35. Kazanowska B, Reich A, Jelen M, Chybicka A: Chronic metastatic neuroblastoma. Pediatr Blood Cancer; 2008 Apr;50(4):898-900
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  • [Title] Chronic metastatic neuroblastoma.
  • The diversity of neuroblastoma and its clinical course depends on histology, biology and clinical features.
  • The diagnosis was made by histological examination of a subcutaneous nodule and elevated urinary markers.
  • We suggest the use of the "chronic neuroblastoma" as a term to describe patients with neuroblastoma showing indolent disease course over a very long period of time, but never achieving complete remission.
  • [MeSH-major] Abdominal Neoplasms / pathology. Neuroblastoma / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / secondary. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Chronic Disease. Humans. Immunohistochemistry. Infant. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Male. Tretinoin / therapeutic use

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 17914736.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5688UTC01R / Tretinoin
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36. Brouwers FM, Eisenhofer G, Lenders JW, Pacak K: Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma. Endocrinol Metab Clin North Am; 2006 Dec;35(4):699-724, viii
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  • [Title] Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma.
  • It is vital to think about this disease in any emergency situation when conventional therapy fails to achieve control or symptoms occur that do not fit the initial diagnosis.
  • The importance of keeping this diagnosis in minds is underscored by the fact that, in 50% of pheochromocytoma patients, the diagnosis is initially overlooked.
  • Two other tumors of the sympathetic nervous system, neuroblastoma and ganglioneuroma, are less commonly associated with emergency conditions.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Ganglioneuroma / complications. Neuroblastoma / complications. Pheochromocytoma / complications

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  • (PMID = 17127142.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Number-of-references] 230
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37. Normand C, Leblond P, Mazingue F, Nelken B, Defachelles AS, Bonnevalle M: A case of adrenal haemorrhage after minor trauma in a young child: think of neuroblastoma. Eur J Pediatr Surg; 2006 Oct;16(5):365-8
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  • [Title] A case of adrenal haemorrhage after minor trauma in a young child: think of neuroblastoma.
  • We report a case of neuroblastoma diagnosed after adrenal haemorrhage following a minor trauma in a thirteen-month-old boy.
  • Therefore when no accepted cause for AH can be found in a young child below the age of 5 years, it is important to look for a neuroblastoma and discuss the necessity of surgical exploration.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hemorrhage / etiology. Neuroblastoma / diagnosis
  • [MeSH-minor] Accidental Falls. Adrenal Glands / blood supply. Fatal Outcome. Humans. Infant. Male. Tomography, X-Ray Computed

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  • (PMID = 17160786.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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38. Pastorino F, Marimpietri D, Brignole C, Di Paolo D, Pagnan G, Daga A, Piccardi F, Cilli M, Allen TM, Ponzoni M: Ligand-targeted liposomal therapies of neuroblastoma. Curr Med Chem; 2007;14(29):3070-8
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  • [Title] Ligand-targeted liposomal therapies of neuroblastoma.
  • Until recently, the most resorted experimental model of paediatric Neuroblastoma (NB) tumour is the subcutaneous xenograft in nude mice.
  • A more realistic view of the clinical potential of targeted therapies could be obtained if a tumour model were available that better reflects the growth of advanced NB in children (i.e. large adrenal gland tumours and multiple small metastatic lesions).
  • This review will focus on the description of the most clinically relevant animal models established to test the efficacy of targeted liposomal anti-tumour formulations for the treatment of Neuroblastoma.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Neuroblastoma / drug therapy
  • [MeSH-minor] Animals. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cell Line, Tumor. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Drug Delivery Systems. Humans. Ligands. Liposomes. Neoplasm Transplantation. Oligonucleotides, Antisense / administration & dosage. Oligonucleotides, Antisense / therapeutic use. Transplantation, Heterologous

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  • (PMID = 18220743.001).
  • [ISSN] 0929-8673
  • [Journal-full-title] Current medicinal chemistry
  • [ISO-abbreviation] Curr. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ligands; 0 / Liposomes; 0 / Oligonucleotides, Antisense; 80168379AG / Doxorubicin
  • [Number-of-references] 77
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39. Gupta R, Dinda AK: Ganglioneuroma of the adrenal gland: a rare case. Indian J Pathol Microbiol; 2007 Oct;50(4):782-4
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  • [Title] Ganglioneuroma of the adrenal gland: a rare case.
  • Ganglioneuromas, which are benign tumors of sympathetic nervous system, are rare to arise in adrenal gland.
  • Currently, histopathology is the only tool to diagnose ganglioneuroma and to differentiate it from ganglioneuroblastoma and neuroblastoma.
  • We discuss the case of a 40-year-old female found to have a right adrenal mass during investigation of dull ache in right upper abdomen.
  • Histological examination showed the mass to be a ganglioneuroma arising in the adrenal gland.
  • In conclusion, ganglioneuroma occurs rarely in adrenal gland and pre-operative diagnosis is difficult since the symptoms are usually non-specific.
  • Histological examination is the mainstay of diagnosis and should be thorough to exclude neuroblastomatous foci, portending a worse outcome.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Ganglioneuroma / diagnosis. Ganglioneuroma / pathology

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  • (PMID = 18306553.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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40. Wu XR, Zhu MH, Zhang ZD: [Expression of KAI1/CD82 in neuroblastoma and its correlation to prognosis]. Ai Zheng; 2005 Jul;24(7):885-9
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  • [Title] [Expression of KAI1/CD82 in neuroblastoma and its correlation to prognosis].
  • Our study was designed to investigate the expression of KAI1/CD82 in neuroblastoma, and explore its correlation to clinicopathologic characteristics and prognosis of patients with neuroblastoma.
  • METHODS: The EnVision immunohistochemistry was used to detect the expression of KAI1/CD82 in 90 specimens of neuroblastoma (28 specimens of ganglioneuroblastoma and 62 specimens of neuroblastoma).
  • RESULTS: Positive rate of KAI1/CD82 was significantly higher in ganglioneuroblastoma than in neuroblastoma (39.3% vs. 14.5%, P=0.014).
  • Its expression was negatively correlated to clinical stage of neuroblastoma (P=0.003).
  • CONCLUSIONS: The change of KAI1/CD82 expression is an early event in tumorigenesis of neuroblastoma.
  • Its down-regulation may be considered as a potential indicator to judge the differentiation and metastasis of neuroblastoma, which can serve as one of the combined indexes to clinical assessment of prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Antigens, CD82 / metabolism. Ganglioneuroblastoma / metabolism. Neuroblastoma / metabolism. Peritoneal Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Lymphatic Metastasis. Lymphatic Vessels / metabolism. Male. Mediastinal Neoplasms / metabolism. Mediastinal Neoplasms / pathology. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 16004821.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD82; 0 / Biomarkers, Tumor
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41. Aktas S, Celebiler AC, Zadeoğlulari Z, Diniz G, Kargi A, Olgun N: Expression and methylation pattern of p16 in neuroblastoma tumorigenesis. Pathol Oncol Res; 2010 Mar;16(1):1-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and methylation pattern of p16 in neuroblastoma tumorigenesis.
  • Understanding migration, population and differentiation of primordial neural crest cells will help in evolving biology of neuroblastoma.
  • The aim of this study was to evaluate the role of p16 and its methylation pattern in neuroblastoma tumorigenesis.
  • P16 was studied in 5 samples of normal adrenal medullar tissue, 5 samples of adrenal tissue including blastic rests, 5 samples of neuroblastoma in situ tissue and in 8 samples of neuroblastoma tissues primary and after chemotherapy in each group.
  • The adrenal gland tissues were obtained from paediatric autopsy cases.
  • The mean age of neuroblastoma cases was 45 months.
  • P16 expression was positive in normal adrenal tissues, in one of 5 samples of adrenal blastic rest tissue and in all of samples of after chemotherapy; while no expression was observed in neuroblastoma and neuroblastoma in situ tissues.
  • P16 methylation was observed in samples of neuroblastoma in situ and primary neuroblastoma tissues.
  • Our results suggest that p16 and its methylation seems to play role in neuroblastoma tumorigenesis and in the migration, population and differentiation of primordial neural crest cells.
  • Inhibitors of DNA methylation may provide a useful tool for restoring p16 activity in neuroblastoma treatment.
  • [MeSH-major] DNA Methylation. Genes, p16. Neuroblastoma / genetics

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  • (PMID = 19466588.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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42. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • [Title] Radiological localizing techniques in adrenal tumors.
  • The characterisation of adrenal lesions is a common radiological dilemma.
  • Incidental adrenal lesions are commonly detected with computed tomography (CT), and lesion characterisation is critical.
  • The prevalence of incidental adrenal lesions has been reported to be 2.3% at autopsy and 0.5-2% with abdominal CT.
  • Although the majority of adrenal lesions are benign, in patients with an extra-adrenal primary cancer the probability of an adrenal mass being a metastasis is 52%.
  • Unfortunately, there may be significant overlap between the imaging appearances of benign lesions such as lipid-poor adenomas and malignant lesions, particularly metastases and small adrenal carcinomas.
  • This review highlights recent advances in radiological imaging of adrenal lesions and we discuss the relative merits of CT and magnetic resonance imaging to aid the identification of benign and malignant adrenal lesions and their roles, in combination with biochemical and clinical data, in recognizing common pathologies such as adrenal adenoma, phaeochromocytoma, carcinoma and metastases.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Incidental Findings. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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43. Zheng LD, Tong QS, Tang ST, Du ZY, Liu Y, Jiang GS, Cai JB: Expression and clinical significance of heparanase in neuroblastoma. World J Pediatr; 2009 Aug;5(3):206-10
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  • [Title] Expression and clinical significance of heparanase in neuroblastoma.
  • However, the expression of HPA in neuroblastoma (NB), one of the most common extra cranial solid tumors in children, remains unknown.
  • The relationships among HPA expression, international neuroblastoma staging system (INSS) stages, histopathological classification, and postoperative survival of the NB patients were analyzed.
  • RESULTS: The expression rate of HPA in NB was 61.9% (26/42), mainly in the cytoplasm of neuroblastoma cells.
  • [MeSH-major] Adrenal Gland Neoplasms / enzymology. Glucuronidase / metabolism. Neuroblastoma / enzymology

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  • (PMID = 19693465.001).
  • [ISSN] 1708-8569
  • [Journal-full-title] World journal of pediatrics : WJP
  • [ISO-abbreviation] World J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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44. Rescorla FJ: Malignant adrenal tumors. Semin Pediatr Surg; 2006 Feb;15(1):48-56
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  • [Title] Malignant adrenal tumors.
  • Adrenal tumors, apart from neuroblastoma, are relatively rare in infancy and childhood.
  • Most adrenal lesions are benign, and both benign and malignant tumors may be hormonally active thus, making accurate preoperative diagnosis difficult.
  • The two main malignant tumors are adrenocortical carcinoma and pheochromocytoma.
  • In both tumors, it may be difficult to determine benign from malignant and the biologic behavior and degree of invasion may portend a more malignant course.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Adrenocortical Carcinoma / diagnosis. Adrenocortical Carcinoma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy

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  • (PMID = 16458846.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 98
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45. Oguzkurt P, Ince E, Temiz A, Demir S, Akabolat F, Hicsonmez A: Prenatal diagnosis of a mass in the adrenal region that proved to be a teratoma. J Pediatr Hematol Oncol; 2009 May;31(5):350-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal diagnosis of a mass in the adrenal region that proved to be a teratoma.
  • Magnetic resonance imaging showed a 57 x 50 mm mass in the left adrenal region displacing the kidney inferiorly.
  • Prenatally detected suprarenal masses are likely to be neuroblastoma or adrenal hemorrhage, but may be rare benign lesions such as extralobar pulmonary sequestration, bronchogenic cyst, or renal dysplasia.
  • Although teratoma in the adrenal region is extremely rare, it should be included in the clinical and radiologic differential diagnosis of prenatally detected suprarenal masses.
  • Total excision of the mass for histologic diagnosis is indicated.
  • [MeSH-major] Adrenal Gland Neoplasms / congenital. Adrenal Gland Neoplasms / diagnosis. Teratoma / congenital. Teratoma / diagnosis. Ultrasonography, Prenatal
  • [MeSH-minor] Adrenalectomy. Biopsy. Diagnosis, Differential. Female. Humans. Infant. Magnetic Resonance Imaging. Male. Pregnancy

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  • (PMID = 19415017.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Sultan I, Ghandour K, Al-Jumaily U, Hashem S, Rodriguez-Galindo C: Local control of the primary tumour in metastatic neuroblastoma. Eur J Cancer; 2009 Jul;45(10):1728-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Local control of the primary tumour in metastatic neuroblastoma.
  • The previous studies have stressed on the importance of loco-regional control in the management of high-risk neuroblastoma.
  • We searched the Surveillance, Epidemiology and End-Results (SEER) database for patients older than 2years with metastatic neuroblastoma who were diagnosed from 1998 to 2005.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Neuroblastoma / secondary. Neuroblastoma / surgery

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  • (PMID = 19447607.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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52. Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T: Concordance for neuroblastoma in monozygotic twins: case report and review of the literature. J Pediatr Surg; 2010 Dec;45(12):2312-6
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  • [Title] Concordance for neuroblastoma in monozygotic twins: case report and review of the literature.
  • Resection of an adrenal tumor and a liver tumor biopsy were performed.
  • Screening by abdominal ultrasonography showed multiple masses in the liver but no adrenal mass.
  • All primary tumor and liver tumor specimens from twin 2 and the liver tumor of twin 1 had the same histologic classification of neuroblastoma and nearly identical genetic aberrations, including a chromosome gain or loss using array-comparative genomic hybridization.
  • In the literature, 9 pairs of concordant twin neuroblastomas, including the current twin, have been presented; and the clinical findings of 5 twin pairs may represent placental metastases from one twin with congenital neuroblastoma to the other twin.
  • This study is the first report presenting the possibility of twin-to-twin metastasis in monozygotic twins with neuroblastoma based on an analysis of the clinical features and genetic aberrations.
  • [MeSH-major] Adrenal Gland Neoplasms / embryology. Diseases in Twins / embryology. Fetofetal Transfusion. Liver Neoplasms / secondary. Neuroblastoma / embryology. Neuroblastoma / secondary. Placenta / pathology. Twins, Monozygotic

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21129536.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 35MRW7B4AD / 3-Iodobenzylguanidine; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide
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53. Hill G, Castellino S, Williams D: Cardiac myxoma after treatment for childhood neuroblastoma. Pediatr Cardiol; 2009 Apr;30(3):340-2
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  • [Title] Cardiac myxoma after treatment for childhood neuroblastoma.
  • An asymptomatic 13 year old with a history of neuroblastoma treated with chemotherapy, radiation therapy, and autologous bone marrow transplant was found to have a cardiac mass on screening echocardiogram.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Heart Neoplasms / etiology. Myxoma / etiology. Neuroblastoma / therapy
  • [MeSH-minor] Adolescent. Cardiac Surgical Procedures. Diagnosis, Differential. Echocardiography. Follow-Up Studies. Humans. Male. Risk Factors. Tomography, X-Ray Computed


54. Fung MM, Viveros OH, O'Connor DT: Diseases of the adrenal medulla. Acta Physiol (Oxf); 2008 Feb;192(2):325-35
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  • [Title] Diseases of the adrenal medulla.
  • The adrenal glands are vital in the organism's response to environmental stress.
  • Pathology within the adrenal medulla and the autonomic nervous system is primarily because of neoplasms.
  • The most common tumour, called phaeochromocytoma when located in the adrenal medulla, originates from chromaffin cells and excretes catecholamines, but may be referred to as secreting paragangliomas when found in extra-adrenal chromaffin cells.

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  • (PMID = 18021328.001).
  • [ISSN] 1748-1716
  • [Journal-full-title] Acta physiologica (Oxford, England)
  • [ISO-abbreviation] Acta Physiol (Oxf)
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL058120-090004; United States / NIDDK NIH HHS / DK / DK060702-05; United States / NHLBI NIH HHS / HL / HL058120-099006; United States / NIDDK NIH HHS / DK / R01 DK060702-05; United States / NHLBI NIH HHS / HL / HL058120-09; United States / NHLBI NIH HHS / HL / P01 HL058120-09; United States / NHLBI NIH HHS / HL / P01 HL058120-099006; United States / NIDDK NIH HHS / DK / R01 DK060702; United States / NHLBI NIH HHS / HL / P01 HL058120; United States / NHLBI NIH HHS / HL / P01 HL058120-090004
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Catecholamines
  • [Number-of-references] 33
  • [Other-IDs] NLM/ NIHMS57919; NLM/ PMC2576282
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55. El-Maghraby T: 131I-MIBG in the diagnosis of primary and metastatic neuroblastoma. Gulf J Oncolog; 2007 Jul;(2):33-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 131I-MIBG in the diagnosis of primary and metastatic neuroblastoma.
  • OBJECTIVE: Neuroblastoma is the third most common malignancy of childhood.
  • 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging.
  • The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease.
  • METHODS: Twenty six patients provisionally diagnosed by clinical and imaging criteria to have neuroblastoma were included.
  • On histopathologic verification 5 of these 26 patients were rediagnosed as non-neuroblastoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Iodine Radioisotopes. Neuroblastoma / radionuclide imaging. Radiopharmaceuticals
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radionuclide imaging. Bone Marrow Neoplasms / radionuclide imaging. Bone Marrow Neoplasms / secondary. Brain Neoplasms / radionuclide imaging. Brain Neoplasms / secondary. Child. Child, Preschool. Female. Humans. Infant. Liver Neoplasms / radionuclide imaging. Liver Neoplasms / secondary. Male. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / radionuclide imaging. Neoplasm Staging. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / radionuclide imaging. Spinal Neoplasms / pathology. Spinal Neoplasms / radionuclide imaging. Technetium Tc 99m Medronate

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  • (PMID = 20084722.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Kuwait
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine; X89XV46R07 / Technetium Tc 99m Medronate
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56. Burke MJ, Cohn SL: Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma. Pediatr Blood Cancer; 2008 Mar;50(3):679-80
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  • [Title] Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma.
  • Opsoclonus-myoclonus syndrome (OMS) is a rare paraneoplastic syndrome that occurs in 2%-3% of patients with neuroblastoma.
  • We report our experience with Rituximab in a patient with neuroblastoma and OMS.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Antibodies, Monoclonal / therapeutic use. Ganglioneuroblastoma / complications. Immunotherapy. Opsoclonus-Myoclonus Syndrome / etiology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Child Behavior Disorders / etiology. Child, Preschool. Combined Modality Therapy. Diagnostic Errors. Humans. Immunoglobulins, Intravenous / therapeutic use. Immunosuppressive Agents / therapeutic use. Learning Disorders / etiology. Male. Psychomotor Disorders / etiology. Recurrence. Rituximab

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 16900484.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunoglobulins, Intravenous; 0 / Immunosuppressive Agents; 4F4X42SYQ6 / Rituximab
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57. Sugito K, Kusafuka T, Hoshino M, Inoue M, Goto H, Ikeda T, Hagiwara N, Koshinaga T, Fukuzawa M, Nakamura M, Shichino H, Chin M, Mugishima H, Saito T, Tanaka Y: Intraoperative radiation therapy for advanced neuroblastoma: the problem of securing the IORT field. Pediatr Surg Int; 2007 Dec;23(12):1203-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative radiation therapy for advanced neuroblastoma: the problem of securing the IORT field.
  • The purpose of this study is to evaluate the efficacy of intraoperative radiation therapy (IORT) and the problem of securing the IORT field in advanced pediatric neuroblastoma.
  • Between 1996 and 2005, 12 children received IORT for advanced pediatric neuroblastoma patients.
  • Nine patients were alive 17-120 (mean 48 months) after diagnosis.
  • For advanced neuroblastoma patients, IORT produced excellent local control after surgery.
  • [MeSH-major] Adrenal Gland Neoplasms / radiotherapy. Adrenalectomy / methods. Intraoperative Care / methods. Laparotomy / methods. Neuroblastoma / radiotherapy. Retroperitoneal Neoplasms / radiotherapy
  • [MeSH-minor] Biopsy. Child. Child, Preschool. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17968560.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Sano H, Gonzalez-Gomez I, Wu SQ, Armenian SH, Jubran RF, Shimada H: A case of composite neuroblastoma composed of histologically and biologically distinct clones. Pediatr Dev Pathol; 2007 May-Jun;10(3):229-32
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  • [Title] A case of composite neuroblastoma composed of histologically and biologically distinct clones.
  • We report a case of a 12-month-old girl with stage 3 neuroblastoma composed of 2 distinct clones in the adrenal primary tumor.
  • One clone showed neuroblastoma, poorly differentiated subtype with a low mitosis-karyorrhexis index (favorable histology), and the other was neuroblastoma, poorly differentiated subtype with a high mitosis-karyorrhexis index (unfavorable histology), according to the International Neuroblastoma Pathology Classification.
  • Lymph nodes from ipsilateral and contralateral sides contained metastatic neuroblastoma of the latter clone.
  • To our knowledge, however, this is the 1st case report of composite tumor with biologically favorable and unfavorable clones in the Neuroblastoma (Schwannian stroma-poor) category.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neuroblastoma / pathology
  • [MeSH-minor] Clone Cells. Female. Ferritins / blood. Homovanillic Acid / urine. Humans. In Situ Hybridization, Fluorescence. Infant. L-Lactate Dehydrogenase / blood. Neoplasm Staging. Nuclear Proteins / metabolism. Oncogene Proteins / metabolism. Treatment Outcome. Vanilmandelic Acid / urine

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  • (PMID = 17535087.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 55-10-7 / Vanilmandelic Acid; 9007-73-2 / Ferritins; EC 1.1.1.27 / L-Lactate Dehydrogenase; X77S6GMS36 / Homovanillic Acid
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59. Kunieda E, Hirobe S, Kaneko T, Nagaoka T, Kamagata S, Nishimura G: Patterns of local recurrence after intraoperative radiotherapy for advanced neuroblastoma. Jpn J Clin Oncol; 2008 Aug;38(8):562-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patterns of local recurrence after intraoperative radiotherapy for advanced neuroblastoma.
  • OBJECTIVE: The purpose of this study was to retrospectively evaluate local recurrence patterns after intraoperative radiation therapy (IORT) combined with total or subtotal resection and intensive chemotherapy for advanced neuroblastoma.
  • METHODS: The outcomes of 27 patients (14 boys and 13 girls) with advanced-stage neuroblastoma who received IORT as part of multimodality therapy between November 1988 and December 2006 were reviewed in order to evaluate the impact of IORT.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adrenal Gland Neoplasms / radiotherapy. Neoplasm Recurrence, Local / diagnosis. Neuroblastoma / radiotherapy. Retroperitoneal Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Infant. Intraoperative Period. Magnetic Resonance Imaging. Male. Neoplasm Staging. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18667476.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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60. Ertle F, Behnisch W, Al Mulla NA, Bessisso M, Rating D, Mechtersheimer G, Hero B, Kulozik AE: Treatment of neuroblastoma-related opsoclonus-myoclonus-ataxia syndrome with high-dose dexamethasone pulses. Pediatr Blood Cancer; 2008 Mar;50(3):683-7
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  • [Title] Treatment of neuroblastoma-related opsoclonus-myoclonus-ataxia syndrome with high-dose dexamethasone pulses.
  • Opsoclonus-myoclonus-ataxia-syndrome (OMS) represents a rare neuroblastoma-associated paraneoplastic syndrome that commonly results in neurologic deficits despite tumor resection and immunosuppressive therapy.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Dexamethasone / therapeutic use. Immunosuppressive Agents / therapeutic use. Neuroblastoma / complications. Opsoclonus-Myoclonus Syndrome / drug therapy


61. Onitake Y, Hiyama E, Kamei N, Yamaoka H, Sueda T, Hiyama K: Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres. J Pediatr Surg; 2009 Dec;44(12):2258-66
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  • [Title] Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres.
  • PURPOSE: Neuroblastoma (NBL) shows remarkable biologic heterogeneity, resulting in favorable or unfavorable prognoses.
  • [MeSH-major] Neuroblastoma / genetics. Telomere / ultrastructure. Telomere-Binding Proteins / metabolism
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / genetics. Adrenal Gland Neoplasms / metabolism. Adrenal Gland Neoplasms / mortality. Blotting, Southern / statistics & numerical data. Child. Child, Preschool. Disease-Free Survival. Drug Resistance, Neoplasm / genetics. Flow Cytometry / statistics & numerical data. Humans. Mass Screening / statistics & numerical data. Mediastinal Neoplasms / genetics. Mediastinal Neoplasms / metabolism. Mediastinal Neoplasms / mortality. Ploidies. Prognosis. Retroperitoneal Neoplasms / genetics. Retroperitoneal Neoplasms / metabolism. Retroperitoneal Neoplasms / mortality. Survival Analysis. Tandem Repeat Sequences / genetics. Telomerase / genetics. Telomerase / metabolism

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  • (PMID = 20006006.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Telomere-Binding Proteins; EC 2.7.7.49 / Telomerase
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62. Moon SB, Park KW, Jung SE, Youn WJ: Neuroblastoma: treatment outcome after incomplete resection of primary tumors. Pediatr Surg Int; 2009 Sep;25(9):789-93
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  • [Title] Neuroblastoma: treatment outcome after incomplete resection of primary tumors.
  • PURPOSE: For International Neuroblastoma Staging System (INSS) stages III or IV neuroblastoma (intermediate or high risk), complete excision of the primary tumor is not always feasible.
  • [MeSH-major] Neuroblastoma / mortality. Neuroblastoma / therapy
  • [MeSH-minor] Adrenal Gland Neoplasms / mortality. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / therapy. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Dermatologic Agents / therapeutic use. Female. Follow-Up Studies. Genes, myc. Humans. Infant. Interleukin-2 / therapeutic use. Isotretinoin / therapeutic use. Male. Mediastinal Neoplasms / mortality. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / therapy. Neoplasm, Residual. Pelvic Neoplasms / mortality. Pelvic Neoplasms / pathology. Pelvic Neoplasms / therapy. Peripheral Blood Stem Cell Transplantation. Radiotherapy, Adjuvant. Retroperitoneal Neoplasms / mortality. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / therapy. Retrospective Studies

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  • (PMID = 19629500.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Dermatologic Agents; 0 / Interleukin-2; EH28UP18IF / Isotretinoin
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63. Paulino AC, Fowler BZ: Risk factors for scoliosis in children with neuroblastoma. Int J Radiat Oncol Biol Phys; 2005 Mar 1;61(3):865-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors for scoliosis in children with neuroblastoma.
  • PURPOSE: To determine the risk factors for scoliosis in children treated for neuroblastoma.
  • METHODS AND MATERIALS: From 1957 to 1997, 58 children with neuroblastoma were treated at one institution and have survived a minimum of 5 years.
  • There were 35 boys and 23 girls with a median age of 6 months (range, 2 weeks to 15 years) at initial diagnosis.
  • Primary site was located in the adrenal gland in 25 (43.1%), abdominal/nonadrenal in 16 (27.6%), thoracic in 12 (20.7%), cervical in 3 (5.3%), and pelvic region in 2 (3.5%).
  • The International Neuroblastoma Staging System (INSS) stage was Stage 1 in 10 (17.2%), Stage 2A in 7 (12.1%), Stage 2B in 5 (8.6%), Stage 3 in 22 (37.9%), Stage 4 in 4 (6.9%), and Stage 4S in 10 (17.2%).
  • Four had scoliosis ranging from 30 degrees to 66 degrees ; 3 of these patients required surgical intervention, whereas 1 had an underlying Duchenne muscular dystrophy which manifested itself 8 years after diagnosis of neuroblastoma.
  • Gender, age at diagnosis, INSS stage, primary site, and use of chemotherapy were not found to be significant.
  • CONCLUSIONS: Treatment-related factors, namely laminectomy and radiotherapy, were found to increase the risk of scoliosis in patients with neuroblastoma.
  • [MeSH-major] Neuroblastoma / radiotherapy. Scoliosis / etiology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Laminectomy / adverse effects. Male. Multivariate Analysis. Neoplasm Staging. Radiotherapy Dosage. Risk Factors

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  • (PMID = 15708267.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Rozovsky K, Koplewitz BZ, Krausz Y, Revel-Vilk S, Weintraub M, Chisin R, Klein M: Added value of SPECT/CT for correlation of MIBG scintigraphy and diagnostic CT in neuroblastoma and pheochromocytoma. AJR Am J Roentgenol; 2008 Apr;190(4):1085-90
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  • [Title] Added value of SPECT/CT for correlation of MIBG scintigraphy and diagnostic CT in neuroblastoma and pheochromocytoma.
  • OBJECTIVE: In pheochromocytoma and neuroblastoma, pathologic findings on metaiodobenzylguanidine (MIBG) scintigraphy (planar and SPECT) and on diagnostic CT are sometimes difficult to correlate.
  • MATERIALS AND METHODS: Eleven patients, three adults (age range, 27-64 years) with pheochromocytoma and eight children (age range, 16-72 months) with neuroblastoma, underwent 15 (123)I-MIBG scintigraphy (whole body and SPECT/CT) and diagnostic CT during follow-up after treatment, with a time interval of 2 to 30 days (mean, 12 days) between MIBG scintigraphy and diagnostic CT.
  • In one case of pheochromocytoma in which anatomy was distorted by previous surgery and contrast agent was not injected, SPECT/CT findings guided the diagnostic CT that had initially misinterpreted the right adrenal gland as the inferior vena cava.
  • In three of 11 studies performed for neuroblastoma, SPECT/CT facilitated the diagnostic CT reading: in one study, a small paravertebral thickening was overlooked at blind CT reading and in another case, SPECT/CT localized and characterized a soft-tissue mass medial to the iliac bone, which was missed on diagnostic CT in an area of difficult differential anatomy (bowel loops and eventual involved lymph nodes).
  • In four additional neuroblastoma studies in which a residual mass was present on diagnostic CT, planar MIBG scintigraphy was negative.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Adrenal Gland Neoplasms / radionuclide imaging. Neuroblastoma / radiography. Neuroblastoma / radionuclide imaging. Pheochromocytoma / radiography. Pheochromocytoma / radionuclide imaging. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed


65. Nevo I, Sagi-Assif O, Edry Botzer L, Amar D, Maman S, Kariv N, Leider-Trejo LE, Savelyeva L, Schwab M, Yron I, Witz IP: Generation and characterization of novel local and metastatic human neuroblastoma variants. Neoplasia; 2008 Aug;10(8):816-27
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  • [Title] Generation and characterization of novel local and metastatic human neuroblastoma variants.
  • Neuroblastoma (NB) is the most commonly occurring solid tumor in children.
  • The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression.
  • Most NB patients with an advanced disease have massive bone marrow infiltration at diagnosis.
  • SH-SY5Y and MHH-NB-11 NB cells were inoculated orthotopically into the adrenal glands of athymic nude mice.
  • Neuroblastoma cells metastasizing to the lungs were isolated from mice bearing adrenal tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Disease Models, Animal. Lung Neoplasms / secondary. Neoplasms, Experimental / secondary. Neuroblastoma / secondary

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  • (PMID = 18683320.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 80168379AG / Doxorubicin; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; J06Y7MXW4D / Deferoxamine
  • [Other-IDs] NLM/ PMC2504768
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66. Hsiao CC, Huang CC, Sheen JM, Tai MH, Chen CM, Huang LL, Chuang JH: Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Mod Pathol; 2005 May;18(5):656-62
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  • [Title] Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma.
  • Neuroblastoma is an extremely malignant solid tumor in children, characterized by spontaneous differentiation and regression.
  • An epidermal growth factor-like homeotic protein, delta-like (dlk), has been involved in differentiation of neuroblastoma cell lines, but is unknown in in vivo expression of neuroblastoma.
  • By using in situ hybridization and immunohistochemistry, dlk mRNA and protein expression were studied in formalin-fixed archival tissues from 10 patients with neuroblastoma, five with ganglioneuroblastoma, and five with ganglioneuroma.
  • Three adrenal tissues from children died of diseases other than adrenal tumors and one from an adult with pheochromocytoma were severed as normal and disease controls.
  • The results showed strong immunoreactive dlk staining in endothelial cells in neuroblastoma, ganglioneuroblastoma and ganglioneuroma.
  • Dlk was detectable in mature neuromatous stroma and gangliocytes of ganglioneuroma, but not in neuroblasts of neuroblastoma and ganglioneuroblastoma, neither in gangliocytes of ganglioneuroblastoma.
  • The findings indicated that there is differential expression of dlk gene and protein among neuroblastoma, ganglioneuroblastoma and ganglioneuroma.
  • The stronger expression of dlk in gangliocytes in ganglioneuroma, in contrast to weaker or no expression in gangliocytes in ganglioneuroblastoma and neuroblasts in neuroblastoma, suggests upregulation of dlk during differentiation of neuroblastoma into more benign form.
  • Furthermore, higher dlk protein expression in the tumor endothelium than in the endothelium of normal adrenal gland implies that dlk may regulate the endothelial function in neuroblastic tumors.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Epidermal Growth Factor / genetics. Epidermal Growth Factor / metabolism. Female. Ganglioneuroblastoma / genetics. Ganglioneuroblastoma / metabolism. Ganglioneuroblastoma / pathology. Ganglioneuroma / genetics. Ganglioneuroma / metabolism. Ganglioneuroma / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization. Infant. Infant, Newborn. Male. Neuroblastoma / genetics. Neuroblastoma / metabolism. Neuroblastoma / pathology. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 15605081.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / RNA, Messenger; 62229-50-9 / Epidermal Growth Factor
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67. Fuchs D, Christofferson R, Stridsberg M, Lindhagen E, Azarbayjani F: Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments. J Transl Med; 2009;7:16
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  • [Title] Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments.
  • BACKGROUND: High-risk neuroblastoma has an overall five-year survival of less than 40%, indicating a need for new treatment strategies such as angiogenesis inhibition.
  • The aim of this study was primarily to characterize tumor spread in an orthotopic, metastatic model for aggressive, MYCN-amplified neuroblastoma and secondarily to study the effects of daily administration of the chemotherapeutic agent CHS 828 on tumor angiogenesis, tumor growth, and spread.
  • METHODS: MYCN-amplified human neuroblastoma cells (IMR-32, 2 x 10(6)) were injected into the left adrenal gland in SCID mice through a flank incision.
  • RESULTS: The orthotopic model resembled clinical neuroblastoma in respect to tumor site, growth and spread.
  • CONCLUSION: The metastatic animal model in this study resembled clinical neuroblastoma and is therefore clinically relevant for examining new treatment strategies for this malignancy.
  • Our results indicate that daily scheduling of CHS 828 may be beneficial in treating patients with high-risk neuroblastoma.
  • [MeSH-major] Cell Compartmentation. Endothelial Cells / pathology. Neuroblastoma / pathology. Neuroblastoma / therapy
  • [MeSH-minor] Animals. Autopsy. Calgranulin A / blood. Cell Line, Tumor. Cyanides / toxicity. Fibroblasts / drug effects. Guanidines / toxicity. Humans. Liver Neoplasms / secondary. Mice. Mice, SCID. Neoplasm Metastasis. Neovascularization, Pathologic / metabolism. Remission Induction. Risk Factors. Xenograft Model Antitumor Assays

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  • [Cites] J Clin Oncol. 2003 Apr 15;21(8):1592-601 [12697885.001]
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  • (PMID = 19284605.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calgranulin A; 0 / Cyanides; 0 / Guanidines; 0 / N-(6-chlorophenoxyhexyl)-N''-cyano-N''-4-pyridylguanidine
  • [Other-IDs] NLM/ PMC2667491
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68. Katanoda K, Hayashi K, Yamamoto K, Sobue T: Secular trends in neuroblastoma mortality before and after the cessation of national mass screening in Japan. J Epidemiol; 2009;19(5):266-70
International Agency for Research on Cancer - Screening Group. diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secular trends in neuroblastoma mortality before and after the cessation of national mass screening in Japan.
  • BACKGROUND: In 2003, the Japanese government halted the national mass screening program for neuroblastoma (NB), which had been running since the mid-1980s.
  • METHODS: Utilizing vital statistics data from 1980 through 2006, we analyzed the secular trends in NB mortality by using cancer of the adrenal gland as a surrogate.
  • RESULTS: The number of deaths from cancer of the adrenal gland was closely correlated with the number of deaths from NB.

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  • (PMID = 19652443.001).
  • [ISSN] 1349-9092
  • [Journal-full-title] Journal of epidemiology
  • [ISO-abbreviation] J Epidemiol
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3924130
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69. Gutweiler JR, Yu DC, Kim HB, Kozakewich HP, Marcus KJ, Shamberger RC, Weldon CB: Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma. J Pediatr Surg; 2008 Dec;43(12):2297-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma.
  • Although there is no evidence for malignant degeneration, FNH can occur adjacent to a malignancy.
  • Here, the case of a 4-year-old boy with a hepatic mass and history of stage IV neuroblastoma is presented.
  • However, after left lateral segmentectomy, pathologic examination revealed a malignant tumor most consistent with small cell undifferentiated hepatoblastoma as well as 3 foci of FNH in the surrounding parenchyma.
  • [MeSH-major] Adrenal Gland Neoplasms. Focal Nodular Hyperplasia / etiology. Hepatoblastoma / diagnosis. Liver Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Neuroblastoma

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  • (PMID = 19040959.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 3F8 antibody; 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; NR7O1405Q9 / Mesna; Q20Q21Q62J / Cisplatin; Q41OR9510P / Melphalan; U3P01618RT / Fluorouracil; UM20QQM95Y / Ifosfamide
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70. Malaise O, Vandenbosch K, Uyttebroeck A, Renard M, Bricteux G: [Retroperitoneal mass in children : clinical cases of Wilms tumor and neuroblastoma]. Rev Med Liege; 2010 Mar;65(3):115-6
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  • [Title] [Retroperitoneal mass in children : clinical cases of Wilms tumor and neuroblastoma].
  • We present the case-reports of 2 children under the age of 5 years admitted to the University Hospital of Liège, one with a Wilms tumor and one with a neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Kidney Neoplasms / diagnosis. Neuroblastoma / diagnosis. Retroperitoneal Neoplasms / diagnosis. Wilms Tumor / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Infant. Male. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome


71. Alcasabas P, Dettore A, Ozgönenel B, Bhambhani K, Ravindranath Y, Savaşan S: Vacuolated neuroblastoma cells mimicking FAB L(3) lymphoblasts in bone marrow aspirates. Pediatr Blood Cancer; 2007 Feb;48(2):227-9
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  • [Title] Vacuolated neuroblastoma cells mimicking FAB L(3) lymphoblasts in bone marrow aspirates.
  • Abundant cytoplasmic vacuolation of neuroblasts has been noted on bone marrow aspirate (BMA) smears of two patients with metastatic neuroblastoma.
  • Cytoplasmic vacuolations of neuroblasts may be a feature of metastatic neuroblastoma cells in BMA smears.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Bone Marrow Cells / pathology. Neuroblastoma / pathology
  • [MeSH-minor] Child, Preschool. Female. Flow Cytometry. Humans. Male. Neoplasm Metastasis / pathology. Phosphopyruvate Hydratase / analysis. Vacuoles / pathology

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  • (PMID = 16425244.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 4.2.1.11 / Phosphopyruvate Hydratase
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72. Nzegwu MA, Aghaji A: Neuroblastoma occurring in a 38-year old Nigerian man: a rare finding. Rare Tumors; 2009;1(1):e15

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroblastoma occurring in a 38-year old Nigerian man: a rare finding.
  • Neuroblastoma (NB) is a common malignancy in children, but rarely occurs in adults.
  • In adults, abdomen/retroperitoneum are the primary sites and in children the adrenal gland.
  • This study emphasizes the need for a standard treatment regime for adult onset neuroblastoma and its recognition as a possible differential in intra-abdominal mass in adults.

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  • (PMID = 21139886.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994447
  • [Keywords] NOTNLM ; adult. / neuroblastoma
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73. Bozzi F, Gambirasio F, Luksch R, Collini P, Brando B, Fossati-Bellani F: Detecting CD56+/NB84+/CD45- immunophenotype in the bone marrow of patients with metastatic neuroblastoma using flow cytometry. Anticancer Res; 2006 Sep-Oct;26(5A):3281-7
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  • [Title] Detecting CD56+/NB84+/CD45- immunophenotype in the bone marrow of patients with metastatic neuroblastoma using flow cytometry.
  • BACKGROUND: In order to identify neuroblastoma cells infiltrating the bone marrow, a triple-color flow-cytometric assay was developed combining CD56 and CD45 with the intracellular anti-NB84 specific antibody.
  • MATERIALS AND METHODS: The bilateral aspirates obtained from 27 consecutive children over the age of one year with stage 4 neuroblastoma were evaluated.
  • RESULTS: Neuroblastoma cells were detected in the bone marrow of 17/27 (63%) and 19/27 (70%) cases using cytomorphology and triple-color flow-cytometry, respectively.
  • CONCLUSION: By combining CD45 and CD56 with the specific antibody, NB84, directed against neuroblastoma cells, we developed a rapid and reliable cytometric assay that can be associated with conventional cytomorphological bone marrow evaluation to detect infiltrating neuroblastoma cells, especially in cases of dubious positivity.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Antigens, CD45 / metabolism. Antigens, CD56 / metabolism. Antigens, Neoplasm / metabolism. Bone Marrow Cells / pathology. Bone Marrow Neoplasms / pathology. Neuroblastoma / diagnosis
  • [MeSH-minor] Adrenal Gland Neoplasms / metabolism. Adrenal Gland Neoplasms / pathology. Biomarkers, Tumor / analysis. Female. Flow Cytometry. Humans. Immunophenotyping. Male. Mediastinal Neoplasms / metabolism. Mediastinal Neoplasms / pathology. Retroperitoneal Neoplasms / metabolism. Retroperitoneal Neoplasms / pathology. Survival Rate

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  • (PMID = 17094441.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD56; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; EC 3.1.3.48 / Antigens, CD45
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74. Zhang N, Lin LK: Presumed primary orbital neuroblastoma in a 20-month-old female. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):383-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presumed primary orbital neuroblastoma in a 20-month-old female.
  • Neuroblastoma is the most common malignant disease of childhood, and it often arises from either the adrenal gland or along the sympathetic chain.
  • The authors report a case of a 20-month-old female with a presumed primary neuroblastoma of the orbit.
  • To the best of the authors' knowledge, primary orbital neuroblastoma has only been previously reported once in children, although it has been reported twice in adults.
  • [MeSH-major] Neuroblastoma / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bone Marrow Transplantation. Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 20622692.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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75. Comstock JM, Willmore-Payne C, Holden JA, Coffin CM: Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma. Am J Clin Pathol; 2009 Jul;132(1):69-73
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  • [Title] Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma.
  • Composite pheochromocytoma is a rare adrenal tumor composed of ordinary pheochromocytoma and other components, most frequently neuroblastic elements.
  • Little is known about its biologic potential, therefore creating a clinical dilemma on diagnosis.
  • This study investigates the clinical characteristics and N-myc amplification status of 4 cases of composite pheochromocytoma and compares them with selected cases of ordinary pheochromocytoma and neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neuroblastoma / pathology. Pheochromocytoma / pathology


76. von Allmen D, Grupp S, Diller L, Marcus K, Ecklund K, Meyer J, Shamberger RC: Aggressive surgical therapy and radiotherapy for patients with high-risk neuroblastoma treated with rapid sequence tandem transplant. J Pediatr Surg; 2005 Jun;40(6):936-41; discussion 941
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive surgical therapy and radiotherapy for patients with high-risk neuroblastoma treated with rapid sequence tandem transplant.
  • BACKGROUND/PURPOSE: The treatment approach for patients with high-risk neuroblastoma has been one of dose intensification chemotherapy and aggressive treatment of the primary tumor.
  • METHODS: Seventy-six patients with high-risk stage III/IV neuroblastoma were treated on a standard protocol incorporating aggressive surgical resection with or without local XRT followed by tandem high-dose chemotherapy and stem cell rescue.
  • CONCLUSION: Aggressive surgical treatment with local XRT and myeloablative chemotherapy with stem cell rescue provides excellent local control in high-risk neuroblastoma, although distant failures, particularly osseous, remain a problem.
  • [MeSH-major] Abdominal Neoplasms / surgery. Adrenal Gland Neoplasms / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / surgery. Head and Neck Neoplasms / surgery. Neuroblastoma / surgery
  • [MeSH-minor] Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Neoplasm Staging. Peripheral Blood Stem Cell Transplantation. Radiotherapy, Adjuvant. Remission Induction / methods. Transplantation, Autologous. Treatment Outcome. Whole-Body Irradiation


77. Elimam NA, Atra AA, Fayea NY, Al-Asaad TG, Khattab TM, Al-Sulami GA, Felimban SK: Stage 4S neuroblastoma, a disseminated tumor with excellent outcome. Saudi Med J; 2006 Nov;27(11):1734-6
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  • [Title] Stage 4S neuroblastoma, a disseminated tumor with excellent outcome.
  • OBJECTIVE: To review the clinical features and outcome of all cases of stage 4S neuroblastoma treated at our center.
  • METHODS: We retrospectively reviewed the files of all patients (n=75) with neuroblastoma treated at King Abdul-Aziz Medical City, Jeddah, Kingdom of Saudi Arabia between 1986 and 2005.
  • We studied the clinical features and outcome of patients with stage 4S neuroblastoma.
  • RESULTS: Six patients (8%) were confirmed to have stage 4S neuroblastoma.
  • Three were boys with a median age at diagnosis of 4.5 months (range 28 days-11 months).
  • CONCLUSION: Stage 4S neuroblastoma is a special tumor that carries excellent prognosis.
  • [MeSH-major] Adrenal Gland Neoplasms. Liver Neoplasms. Neuroblastoma
  • [MeSH-minor] Adrenal Glands / pathology. Age Factors. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Agents, Phytogenic / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Carboplatin / administration & dosage. Carboplatin / therapeutic use. Cyclophosphamide / administration & dosage. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Etoposide / administration & dosage. Etoposide / therapeutic use. Female. Follow-Up Studies. Hepatomegaly / diagnosis. Hepatomegaly / etiology. Humans. Infant. Infant, Newborn. Male. Neoplasm Regression, Spontaneous. Neoplasm Staging. Prognosis. Retrospective Studies. Saudi Arabia. Skin / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Neoplasms / secondary. Survival Analysis. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Vincristine / administration & dosage. Vincristine / therapeutic use

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  • (PMID = 17106552.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; CAV protocol
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78. Joseph JM, Gross N, Lassau N, Rouffiac V, Opolon P, Laudani L, Auderset K, Geay JF, Mühlethaler-Mottet A, Vassal G: In vivo echographic evidence of tumoral vascularization and microenvironment interactions in metastatic orthotopic human neuroblastoma xenografts. Int J Cancer; 2005 Mar 1;113(6):881-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo echographic evidence of tumoral vascularization and microenvironment interactions in metastatic orthotopic human neuroblastoma xenografts.
  • Human neuroblastoma (NB) is the second most frequent solid tumor of childhood and represents a highly heterogeneous disease at clinical and biologic levels.
  • Results show that implantation of low numbers of NB cells directly into the adrenal gland of nude mice resulted in rapid and homogeneous tumor growth without tumor morbidity.
  • Nude mice were shown to rapidly develop highly vascularized adrenal tumors that selectively metastasized to the liver and bone marrow.
  • In addition, the newly formed mouse vessels in orthotopic but not in heterotopic tumors, were found to express the highly angiogenic alphavbeta3 integrin marker, indicating the development of a truly malignant neovasculature in orthotopic conditions only.
  • [MeSH-major] Neovascularization, Pathologic / pathology. Neuroblastoma / blood supply. Neuroblastoma / pathology
  • [MeSH-minor] Animals. Cell Division. Cell Line, Tumor. Child. Genes, Reporter. Green Fluorescent Proteins / analysis. Green Fluorescent Proteins / genetics. Humans. Immunohistochemistry. Male. Mice. Mice, Inbred ICR. Mice, Nude. Mice, SCID. Microcirculation / pathology. Neoplasm Metastasis. Transfection. Transplantation, Heterologous

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  • [Copyright] (c) 2004 Wiley-Liss, Inc.
  • (PMID = 15514941.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins
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79. Ribatti D, Poliani PL, Longo V, Mangieri D, Nico B, Vacca A: Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma. Histopathology; 2007 Apr;50(5):636-41
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  • [Title] Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma.
  • AIMS: Previous studies have shown that increased vascularity is associated with tumour progression in human neuroblastoma (NB).
  • [MeSH-major] Adrenal Gland Neoplasms / blood supply. Erythropoietin / metabolism. Neovascularization, Pathologic / metabolism. Neuroblastoma / blood supply. Receptors, Erythropoietin / metabolism. Spinal Neoplasms / blood supply
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Fluorescent Antibody Technique, Direct. Humans. Immunoenzyme Techniques. Microcirculation. Neoplasm Staging

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  • (PMID = 17394500.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Erythropoietin; 11096-26-7 / Erythropoietin
  • [Other-IDs] NLM/ PMC1890992
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80. Khan T, Hixon JA, Stauffer JK, Lincoln E, Back TC, Brenner J, Lockett S, Nagashima K, Powell D, Wigginton JM: Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma. J Natl Cancer Inst; 2006 Feb 1;98(3):190-202
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  • [Title] Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma.
  • BACKGROUND: Patients with advanced neuroblastoma have a poor prognosis.
  • The antiapoptotic protein Akt has been implicated as a possible mediator of the resistance of human neuroblastoma cells to apoptosis; the proapoptotic protein Bid, is inhibited by activated Akt.
  • Neuroblastoma has demonstrated responsiveness to immunotherapeutic approaches in preclinical studies, prompting investigation of new therapeutic strategies based on potentiation of the host immune response, including the use of systemic cytokines.
  • METHODS: We examined the antitumor efficacy and mechanisms of action of the central immunoregulatory cytokine interleukin-12 (IL-12) in mice bearing established orthotopic neuroblastoma tumors derived from murine TBJ and Neuro-2a cells.
  • Cohorts of mice (10 mice/group) bearing established orthotopic neuroblastoma tumors were injected intraperitoneally with IL-12 or vehicle and monitored for survival.
  • RESULTS: IL-12 induced complete tumor regression and long-term survival of 8 (80%) of 10 mice bearing established neuroblastoma tumors compared with 1 (10%) of 10 control mice (P = .0055) and profound tumor cell apoptosis in vivo despite the fact that TBJ and Neuro-2a cells were resistant to receptor-mediated apoptosis in vitro.
  • These cells expressed high levels of phosphorylated Akt, a key prosurvival molecule, and Akt inhibitors sensitized neuroblastoma cells to apoptosis mediated by IL-12-inducible cytokines including tumor necrosis factor-alpha and interferon-gamma in vitro.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Interleukin-12 / pharmacology. Neuroblastoma / drug therapy. Neuroblastoma / enzymology. Proto-Oncogene Proteins c-akt / drug effects. Proto-Oncogene Proteins c-akt / metabolism
  • [MeSH-minor] Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / enzymology. Animals. Apoptosis / drug effects. BH3 Interacting Domain Death Agonist Protein / drug effects. BH3 Interacting Domain Death Agonist Protein / metabolism. Blotting, Western. Cell Line, Tumor. Enzyme-Linked Immunosorbent Assay. Fluorescent Dyes. Gene Expression Regulation, Enzymologic / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Green Fluorescent Proteins / drug effects. Green Fluorescent Proteins / metabolism. Immunohistochemistry. Indoles. Interferon-gamma / drug effects. Interferon-gamma / metabolism. Mice. Microscopy, Confocal. Neoplasm Transplantation. Phosphorylation / drug effects. Tumor Necrosis Factor-alpha / drug effects. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 16449679.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / BH3 Interacting Domain Death Agonist Protein; 0 / Bid protein, mouse; 0 / Fluorescent Dyes; 0 / Indoles; 0 / Tumor Necrosis Factor-alpha; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; 187348-17-0 / Interleukin-12; 47165-04-8 / DAPI; 82115-62-6 / Interferon-gamma; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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81. Singh M, Arora P, Singh S, Bohara S, Khurana N, Zutshi V, Kumar R: Adult neuroblastoma of the ovary: a rare tumor with review of literature. J Cancer Res Ther; 2010 Jul-Sep;6(3):367-9
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  • [Title] Adult neuroblastoma of the ovary: a rare tumor with review of literature.
  • Neuroblastoma is a tumor of pediatric age group and is extremely rare in adults.
  • Common sites involved in adults are almost similar to that seen in children like retroperitoneum, adrenal gland, pelvis and mediastinum.
  • Ovarian neuroblastoma has never been reported in the literature before.
  • We, hereby, present a case of a 38-year-old lady with bilateral ovarian neuroblastoma diagnosed as Krukenberg's tumor clinicoradiologically.
  • [MeSH-major] Neuroblastoma / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 21119280.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
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82. McHugh K: Renal and adrenal tumours in children. Cancer Imaging; 2007;7:41-51
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  • [Title] Renal and adrenal tumours in children.
  • The differential diagnosis of renal and supra-renal masses firstly depends on the age of the child.
  • Neuroblastoma (NBL) may be seen antenatally or in the newborn period; this tumour has a good prognosis unlike NBL seen in older children (particularly NBL in those aged 2-4 years).
  • Adrenal adenomas and carcinomas also occur in childhood; these tumours are indistinguishable on imaging but criteria for the diagnosis of adrenal carcinoma include size larger than 5 cm, a tendency to invade the inferior vena cava and to metastasise.
  • The most topical dilemmas in the radiological assessment of renal and adrenal tumours are presented.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Diagnostic Imaging / methods. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Age of Onset. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / epidemiology. Child. Child, Preschool. Diagnosis, Differential. Ganglioneuroblastoma / diagnosis. Ganglioneuroblastoma / epidemiology. Ganglioneuroblastoma / pathology. Humans. Infant. Infant, Newborn. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Mass Screening. Neoplasm Staging. Neuroblastoma / diagnosis. Neuroblastoma / epidemiology. Neuroblastoma / pathology. Neuroblastoma / secondary. Neuroblastoma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / epidemiology. Positron-Emission Tomography. Tomography, X-Ray Computed. Wilms Tumor / diagnosis. Wilms Tumor / epidemiology. Wilms Tumor / pathology. Wilms Tumor / therapy

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  • (PMID = 17339140.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 19
  • [Other-IDs] NLM/ PMC1828369
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83. Agayev A, Yilmaz S, Cekrezi B, Yekeler E: Extralobar pulmonary sequestration mimicking neuroblastoma. J Pediatr Surg; 2007 Sep;42(9):1627-9
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  • [Title] Extralobar pulmonary sequestration mimicking neuroblastoma.
  • Intra-abdominal extralobar sequestration should also be kept in differential diagnosis in cases of masses in the suprarenal location.
  • [MeSH-major] Adrenal Gland Diseases / radiography. Adrenal Gland Neoplasms / radiography. Bronchopulmonary Sequestration / radiography. Neuroblastoma / radiography
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant, Newborn. Male. Tomography, X-Ray Computed


84. Jacobson AF, Deng H, Lombard J, Lessig HJ, Black RR: 123I-meta-iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: results of a meta-analysis. J Clin Endocrinol Metab; 2010 Jun;95(6):2596-606
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  • [Title] 123I-meta-iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: results of a meta-analysis.
  • OBJECTIVE: A meta-analysis was performed to obtain best estimates of performance characteristics of (123)I-mIBG imaging for the two most common applications, evaluation of patients with neuroblastoma and pheochromocytoma.
  • DATA SYNTHESIS: Sensitivity of (123)I-mIBG scans for detection of neuroblastoma was 97% [95% confidence interval (CI), 95 to 99%]; data were insufficient to estimate specificity.
  • CONCLUSION: Based upon the literature, (123)I-mIBG scintigraphy has sensitivity and specificity greater than 90% for detection of neuroblastoma and pheochromocytoma.
  • [MeSH-major] 3-Iodobenzylguanidine. Adrenal Gland Neoplasms / radionuclide imaging. Neuroblastoma / radionuclide imaging. Pheochromocytoma / radionuclide imaging. Radiopharmaceuticals

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  • (PMID = 20392867.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine
  • [Number-of-references] 59
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85. Kamoun M, Mnif MF, Rekik N, Belguith N, Charfi N, Mnif L, Elleuch M, Mnif F, Kamoun T, Mnif Z, Kamoun H, Sellami-Boudawara T, Hachicha M, Abid M: Ganglioneuroma of adrenal gland in a patient with Turner syndrome. Ann Diagn Pathol; 2010 Apr;14(2):133-6
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  • [Title] Ganglioneuroma of adrenal gland in a patient with Turner syndrome.
  • Computed tomography disclosed a well-defined solid lesion in the left adrenal measuring 6.5 x 5 cm with minimal contrast enhancement.
  • Histologic examination revealed an encapsulated mass originated from the left adrenal medulla.
  • The tumor was diagnosed as left adrenal ganglioneuroma.
  • Patients with this syndrome are predisposed to the development of neuroblastoma and related tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / pathology. Ganglioneuroma / complications. Ganglioneuroma / pathology. Turner Syndrome / complications

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20227019.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. McGarvey CK, Applegate K, Lee ND, Sokol DK: False-positive metaiodobenzylguanidine scan for neuroblastoma in a child with opsoclonus-myoclonus syndrome treated with adrenocorticotropic hormone (acth). J Child Neurol; 2006 Jul;21(7):606-10
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  • [Title] False-positive metaiodobenzylguanidine scan for neuroblastoma in a child with opsoclonus-myoclonus syndrome treated with adrenocorticotropic hormone (acth).
  • We describe the case of a 2-year-old girl with opsoclonus-myoclonus syndrome treated with chronic adrenocorticotropic hormone (ACTH) in which a metaiodobenzylguanidine scan showed abnormal radiotracer uptake in the left adrenal gland region, interpreted as the site of an occult neuroblastoma.
  • As this finding was not corroborated by previous or subsequent metaiodobenzylguanidine scans or by computed tomography (CT) or magnetic resonance imaging (MRI), we attribute the finding to being a false-positive result from adrenal hyperplasia owing to chronic use of ACTH and not to neuroblastoma.
  • Metaiodobenzylguanidine scintigraphy is an extremely important nuclear medicine examination tool used for the evaluation and staging of pediatric neuroblastoma.
  • We highlight the need for cautious interpretation of metaiodobenzylguanidine as a screening tool for neuroblastoma in patients treated with ACTH.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnostic imaging. Adrenocorticotropic Hormone / therapeutic use. Hormones / therapeutic use. Neuroblastoma / diagnostic imaging. Opsoclonus-Myoclonus Syndrome / diagnostic imaging. Opsoclonus-Myoclonus Syndrome / drug therapy


87. Saad DF, Gow KW, Milas Z, Wulkan ML: Laparoscopic adrenalectomy for neuroblastoma in children: a report of 6 cases. J Pediatr Surg; 2005 Dec;40(12):1948-50
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  • [Title] Laparoscopic adrenalectomy for neuroblastoma in children: a report of 6 cases.
  • Neuroblastoma, a neoplasm of the sympathetic nervous system, is the most common solid extracranial tumor of childhood.
  • Complete tumor resection has been shown to improve outcomes in both low- and high-risk neuroblastoma.
  • The authors describe the technical aspects of LA in 6 children with adrenal neuroblastomas greater than 2 cm and summarize their outcomes.
  • The average size of the adrenal tumors resected was 3.3 x 3.7 x 3.3 cm, and there were no intraoperative or perioperative deaths.
  • Our preliminary data suggest LA is a safe treatment option for neuroblastoma tumors greater than 2 cm in the select children.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Neuroblastoma / surgery

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  • (PMID = 16338326.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Schiavetti A, Foco M, Ingrosso A, Chiriacò D, Ballesio L: Congenital stage 1 neuroblastoma evolved into stage 4s. J Pediatr Hematol Oncol; 2009 Jan;31(1):59-60
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  • [Title] Congenital stage 1 neuroblastoma evolved into stage 4s.
  • A newborn with a prenatally detected adrenal mass underwent complete resection of a stage 1 favorable histology neuroblastoma (NB) without MYC-N amplification.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasm Regression, Spontaneous. Neuroblastoma / pathology. Ultrasonography, Prenatal
  • [MeSH-minor] Female. Genes, myc. Humans. Infant, Newborn. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Male. Neoplasm Staging. Neoplasm, Residual / prevention & control. Pregnancy

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  • (PMID = 19125091.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Rózsai B, Szász M, Ottóffy G, Mohay G, Major A, Németh G, Adamovich K: [Different clinical forms of adrenal abscess in two newborns]. Orv Hetil; 2006 Aug 6;147(31):1455-8
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  • [Title] [Different clinical forms of adrenal abscess in two newborns].
  • Adrenal abscess is a rare disease in the neonatal period.
  • The authors present the histories of two mature, male newborns with adrenal hemorrhage, where the size of the masses increased progressively and finally adrenal abscesses were developed.
  • The first case showed the classical symptoms of adrenal abscess, however, the antibiotic treatment led to complete remission of the symptoms and laboratory infectious markers, therefore the baby was discharged.
  • In the second newborn the increasing adrenal hemorrhage was accompanied by elevated infectious markers despite of the different antibiotic treatments, however, he showed no clinical signs of infection.
  • Because of the discrepancies between the clinical and laboratory findings and also the imaging studies the possibility of neuroblastoma has also arisen.
  • [MeSH-major] Abscess / diagnosis. Adrenal Gland Diseases / diagnosis
  • [MeSH-minor] Anti-Infective Agents / therapeutic use. Bacteroides fragilis / isolation & purification. Diagnosis, Differential. Humans. Infant, Newborn. Male. Metronidazole / therapeutic use. Multiple Organ Failure / etiology. Treatment Outcome

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  • (PMID = 16981418.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 140QMO216E / Metronidazole
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90. Boller D, Schramm A, Doepfner KT, Shalaby T, von Bueren AO, Eggert A, Grotzer MA, Arcaro A: Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells. Clin Cancer Res; 2008 Feb 15;14(4):1172-81
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  • [Title] Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.
  • PURPOSE: The phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in human cancer and plays a crucial role in neuroblastoma biology.
  • We were interested in gaining further insight into the potential of targeting PI3K/Akt signaling as a novel antiproliferative approach in neuroblastoma.
  • RESULTS: Overexpression of the catalytic p110delta and regulatory p85alpha isoforms was detected in a panel of primary neuroblastoma samples and cell lines, compared with normal adrenal gland tissue.
  • CONCLUSIONS: Together, our data reveal a novel function of p110delta in neuroblastoma growth and survival.
  • [MeSH-major] Cell Proliferation. Cell Survival / physiology. Neuroblastoma / enzymology. Phosphatidylinositol 3-Kinases / metabolism


91. Fukushi D, Watanabe N, Kasai F, Haruta M, Kikuchi A, Kikuta A, Kato K, Nakadate H, Tsunematsu Y, Kaneko Y: Centrosome amplification is correlated with ploidy divergence, but not with MYCN amplification, in neuroblastoma tumors. Cancer Genet Cytogenet; 2009 Jan 1;188(1):32-41
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  • [Title] Centrosome amplification is correlated with ploidy divergence, but not with MYCN amplification, in neuroblastoma tumors.
  • Ploidy is an important biologic feature defining heterogeneous neuroblastoma.
  • [MeSH-major] Centrosome / metabolism. Chromosomes, Human, Pair 1 / genetics. Gene Dosage. Neuroblastoma / genetics. Nuclear Proteins / genetics. Oncogene Proteins / genetics. Ploidies
  • [MeSH-minor] Adrenal Gland Neoplasms / genetics. Child. Child, Preschool. Flow Cytometry. Gene Amplification. Humans. In Situ Hybridization, Fluorescence. Infant. Infant, Newborn. Mediastinal Neoplasms / genetics. Retroperitoneal Neoplasms / genetics

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  • (PMID = 19061778.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins
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92. Haberal M, Ozcay F, Sevmis S, Karakayali H, Moray G, Torgay A, Coskun M, Demirhan B, Sarialioglu F, Arslan G: Liver transplant in an infant with bilateral cystic neuroblastoma complicated by hepatic metastases and life-threatening consumption coagulopathy. Pediatr Transplant; 2008 May;12(3):358-62
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  • [Title] Liver transplant in an infant with bilateral cystic neuroblastoma complicated by hepatic metastases and life-threatening consumption coagulopathy.
  • Here we report a patient with stage-4 bilateral cystic adrenal neuroblastomas with disseminated liver metastases and consumption coagulopathy who underwent liver transplant.
  • Our patient was initially diagnosed with infantile hepatic hemangioendothelioma and bleeding into the adrenal glands secondary to consumption coagulopathy (Kasabach-Merritt syndrome).
  • Liver transplant was performed as a life-saving procedure under this diagnosis.
  • We discuss this unique patient because of the diagnostic pitfalls of this rare disease and the successful clinical outcome after LT and subsequent chemotherapy for neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Disseminated Intravascular Coagulation / therapy. Liver Neoplasms / pathology. Liver Transplantation / methods. Neuroblastoma / pathology
  • [MeSH-minor] Adrenal Glands / pathology. Antineoplastic Agents / therapeutic use. Female. Humans. Infant. Living Donors. Neoplasm Metastasis. Treatment Outcome


93. Chang BH, Koch T, Hopkins K, Malempati S: Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus. Pediatr Neurol; 2006 Sep;35(3):213-5
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  • [Title] Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
  • Opsoclonus-myoclonus, a rare paraneoplastic syndrome that may occur in patients with neuroblastoma, is thought to be a humorally mediated immune reaction to malignant cells that cross-react with autoantigens.
  • This report describes the case of an occult neuroblastoma diagnosed in a 4-year-old female 2 years after presentation of opsoclonus-myoclonus.
  • Although no mass was evident on previous imaging at an interval of 10 months, a computed tomographic scan 4 months after rituximab treatment and 20 months after presentation revealed a new left adrenal mass.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Antibodies, Monoclonal / therapeutic use. Immunosuppressive Agents / therapeutic use. Neuroblastoma / diagnosis. Opsoclonus-Myoclonus Syndrome / drug therapy

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  • (PMID = 16939863.001).
  • [ISSN] 0887-8994
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunosuppressive Agents; 4F4X42SYQ6 / Rituximab
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94. Ilias I, Pacak K: Diagnosis and management of tumors of the adrenal medulla. Horm Metab Res; 2005 Dec;37(12):717-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of tumors of the adrenal medulla.
  • The adrenal medulla consists of chromaffin cells, the site of catecholamine biosynthesis.
  • Pheochromocytomas are chromaffin-cell tumors; 80-85 % arise from the adrenal medulla and 15-20 % arise from extra-adrenal chromaffin tissues (paragangliomas).
  • Pheochromocytomas account for 6.5 % of incidentally discovered adrenal tumors; they are found in 50 % of patients with multiple endocrine neoplasia 2A (MEN 2A) and 5-25 % of patients with von Hippel-Lindau (VHL) syndrome.
  • The diagnosis of pheochromocytoma should first be established biochemically by measuring plasma free metanephrines (the measurement of urinary fractionated metanephrines is the second choice).
  • Measurements of homovanillic acid (HVA), norepinephrine and vanilmandelic acid (VMA) in urine are a necessity in patients with suspected neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Adrenal Medulla / physiopathology. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / therapy
  • [MeSH-minor] Humans. Multiple Endocrine Neoplasia Type 2a / diagnosis. Multiple Endocrine Neoplasia Type 2a / therapy. Neuroblastoma / diagnosis. Neuroblastoma / therapy. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy. Prognosis

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  • (PMID = 16372223.001).
  • [ISSN] 0018-5043
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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95. Tang JY, Pan C, Chen J, Xu M, Chen J, Xue HL, Gu LJ, Dong R, Ye H, Zhou M, Wang YP: [Comprehensive protocol for diagnosis and treatment of childhood neuroblastoma--results of 45 cases]. Zhonghua Er Ke Za Zhi; 2006 Oct;44(10):770-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comprehensive protocol for diagnosis and treatment of childhood neuroblastoma--results of 45 cases].
  • OBJECTIVE: The aim of the paper was to improve the prognosis of neuroblastoma (NB) stage III and IV in children through the comprehensive therapy including chemotherapy, delayed tumor resection, autologous stem cell transplantation (ASCT) and inducing differentiation and to analyze the factors affecting the prognosis.
  • METHODS: Newly diagnosed neuroblastoma patients seen from Oct.1998 to Dec.2003 were divided into high, medium and low risk groups depending on clinical stage and age.
  • Of them, 15 were found to have the tumor in adrenal gland, 12 had the tumor extended to the retro-peritoneal space, while in 15 cases the tumor was beside the spinal column in chest and in 3 the tumor was located in other places.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hematopoietic Stem Cell Transplantation. Neuroblastoma / diagnosis. Neuroblastoma / therapy. Transplantation, Autologous
  • [MeSH-minor] Age Factors. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Male. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Prognosis. Remission Induction / methods. Retrospective Studies. Severity of Illness Index. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 17229383.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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96. Kim EY, Yoo SY, Kim JH, Sung KW: Pancreatic metastasis in a child suffering with treated stage 4 neuroblastoma. Korean J Radiol; 2008 Jan-Feb;9(1):84-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreatic metastasis in a child suffering with treated stage 4 neuroblastoma.
  • We present here a very rare case of metastatic relapse in the pancreas of a 4-year-old boy who had been treated for stage 4 neuroblastoma.
  • To the best of our knowledge, this is the first case report of pancreatic metastasis in a child with neuroblastoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neuroblastoma / secondary. Pancreatic Neoplasms / secondary
  • [MeSH-minor] Child, Preschool. Contrast Media. Diagnosis, Differential. Diagnostic Imaging. Humans. Male


97. Takahashi H, Manabe A, Aoyama C, Kamiya T, Kato I, Takusagawa A, Ogawa C, Ozawa M, Hosoya R, Yokoyama K: Iodine-131-metaiodobenzylguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma. Pediatr Blood Cancer; 2008 Mar;50(3):676-8
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  • [Title] Iodine-131-metaiodobenzylguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma.
  • Neuroblastoma is the most common extracranial solid tumor of childhood, and iodine-131-metaiodobenzylguanidine (MIBG) therapy is a new approach for grade IV neuroblastoma.
  • We describe the case history of a 3-year-old girl with recurrent neuroblastoma who received MIBG therapy with reduced-intensity allogeneic stem cell transplantation (RIST) because of an extensive bone marrow involvement.
  • [MeSH-major] 3-Iodobenzylguanidine / therapeutic use. Adrenal Gland Neoplasms / surgery. Bone Marrow Transplantation. Iodine Radioisotopes / therapeutic use. Neuroblastoma / radiotherapy. Neuroblastoma / secondary. Salvage Therapy. Transplantation Conditioning


98. Hsieh CC, Chao AS, Hsu JJ, Chang YL, Lo LM: Real-time and power Doppler imaging of fetal adrenal hemorrhage. Chang Gung Med J; 2005 Dec;28(12):860-5
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  • [Title] Real-time and power Doppler imaging of fetal adrenal hemorrhage.
  • Adrenal hemorrhages are not uncommon in newborns, but they may occur before birth.
  • The incidence of adrenal hemorrhages based on extensive necropsy has been estimated as about 1.7 per 1000 births.
  • With the increasing use of ultrasonography, prenatal recognition of fetal adrenal hemorrhages has become more common in recent years.
  • Since the mass was close to the kidney, we performed power Doppler imaging to localize the lesion and tried to make a differential diagnosis.
  • The left adrenal mass was posterior to the stomach and was without pulsatile blood flow inside.
  • After birth, sonography confirmed a solid homogenous adrenal mass in the newborn.
  • Seven days after birth, the persistent adrenal echogenic mass without resolution by computerized tomography led to a diagnosis of neuroblastoma.
  • The mass was removed by surgery and adrenal hemorrhage diagnosed.
  • The outcome of the adrenal hemorrhage was excellent.
  • The differential diagnosis in unilateral adrenal mass is difficult from the images of 2-D ultrasound since similar pictures may occur among them.
  • In this case, accurate localization of an adrenal mass is feasible using power Doppler imaging (PDI) before birth by determining its blood supply from the middle suprarenal artery.
  • At the same time, fetal adrenal hemorrhages can be demonstrated as an avascular mass, which is the major difference from adrenal tumors.
  • In conclusion, PDI offered more information to localize the adrenal glands from other lesions by separating the blood supply.
  • In addition, the avascular adrenal mass favors the prenatal diagnosis of adrenal hemorrhage.
  • [MeSH-major] Adrenal Gland Diseases / ultrasonography. Fetal Diseases / ultrasonography. Hemorrhage / ultrasonography. Ultrasonography, Doppler. Ultrasonography, Prenatal

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  • (PMID = 16515020.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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99. Misseri R: Adrenal surgery in the pediatric population. Curr Urol Rep; 2007 Jan;8(1):89-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal surgery in the pediatric population.
  • Adrenal tumors in children may be benign or malignant.
  • In addition, both benign and malignant tumors may be hormonally active, leading to hypertension, metabolic crises, and endocrinopathies.
  • Both a metabolic and a radiographic work-up are required before treatment of an adrenal tumor.
  • The primary therapy for most adrenal lesions is surgical, though some are treated medically or require chemotherapy before excision.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods
  • [MeSH-minor] Adrenal Gland Diseases / mortality. Adrenal Gland Diseases / pathology. Adrenal Gland Diseases / surgery. Adrenal Glands / embryology. Adrenal Glands / physiopathology. Age Factors. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Laparoscopy / methods. Male. Neuroblastoma / mortality. Neuroblastoma / pathology. Neuroblastoma / surgery. Pheochromocytoma / mortality. Pheochromocytoma / pathology. Pheochromocytoma / surgery. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 17239322.001).
  • [ISSN] 1534-6285
  • [Journal-full-title] Current urology reports
  • [ISO-abbreviation] Curr Urol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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100. Mori H, Nagata M, Nishijima N, Nagura K, Igarashi H, Hamazaki M, Ozono S, Sugimura H: Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization. Pathol Int; 2008 Aug;58(8):518-23
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  • [Title] Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization.
  • A peculiar adrenal tumor was analyzed using immunohistochemistry, electron microscopy, and fluorescence in situ hybridization (FISH) with multiple bacterial artificial chromosome (BAC) probes.
  • Her serum and urine dopamine level were elevated, and a diagnosis of malignant pheochromocytoma was made.
  • On post-mortem an adrenal tumor composed of small round cells forming Homer Wright rosette-like structures, a feature rarely observed in pheochromocytoma, was found.
  • Because these results did not rule out a diagnosis of neuroblastoma, the tumor was further characterized on FISH with multiple BAC probes for loci known to be altered in neuroblastoma or pheochromocytoma, according to information in the literature that was for the most part obtained using comparative genomic hybridization.
  • FISH demonstrated loss of heterozygosity at 11p, and gains at 16p, 19p, and 19q, a profile that favored a diagnosis of malignant pheochromocytoma over neuroblastoma.
  • This case demonstrates that repeating FISH is useful for differential diagnosis.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. In Situ Hybridization, Fluorescence / methods. Neuroblastoma / diagnosis. Pheochromocytoma / pathology
  • [MeSH-minor] Adult. Chromosomes, Artificial, Bacterial / chemistry. Chromosomes, Artificial, Bacterial / genetics. DNA Probes / chemistry. DNA, Neoplasm / analysis. Diagnosis, Differential. Dopamine / blood. Fatal Outcome. Female. Humans






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