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1. Kantorovich V, Eisenhofer G, Pacak K: Pheochromocytoma: an endocrine stress mimicking disorder. Ann N Y Acad Sci; 2008 Dec;1148:462-8
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  • [Title] Pheochromocytoma: an endocrine stress mimicking disorder.
  • A pheochromocytoma is an endocrine tumor that can uniquely mimic numerous stress-associated disorders, with variations in clinical manifestations resulting from different patterns of catecholamine secretion and actions of released catecholamines on physiological systems.
  • [MeSH-major] Adrenal Gland Neoplasms / physiopathology. Endocrine System Diseases / physiopathology. Pheochromocytoma / physiopathology. Stress Disorders, Traumatic / physiopathology. Stress, Physiological. Stress, Psychological / physiopathology

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  • (PMID = 19120142.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 HD999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Adrenergic; X4W3ENH1CV / Norepinephrine; YKH834O4BH / Epinephrine
  • [Other-IDs] NLM/ NIHMS66489; NLM/ PMC2693284
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2. Gonias S, Goldsby R, Matthay KK, Hawkins R, Price D, Huberty J, Damon L, Linker C, Sznewajs A, Shiboski S, Fitzgerald P: Phase II study of high-dose [131I]metaiodobenzylguanidine therapy for patients with metastatic pheochromocytoma and paraganglioma. J Clin Oncol; 2009 Sep 1;27(25):4162-8
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  • [Title] Phase II study of high-dose [131I]metaiodobenzylguanidine therapy for patients with metastatic pheochromocytoma and paraganglioma.
  • PURPOSE: To evaluate the safety and efficacy of high-dose [(131)I]metaiodobenzylguanidine ([(131)I]MIBG) in the treatment of malignant pheochromocytoma (PHEO) and paraganglioma (PGL).
  • Additionally, 35% of patients achieved a CR or PR in at least one measure of response without progressive disease, and 8% of patients maintained stable disease for greater than 12 months.
  • Thirty-five percent of patients experienced progressive disease within 1 year after therapy.
  • Grades 3 to 4 nonhematologic toxicity included acute respiratory distress syndrome (n = 2), bronchiolitis obliterans organizing pneumonia (n = 2), pulmonary embolism (n = 1), fever with neutropenia (n = 7), acute hypertension (n = 10), infection (n = 2), myelodysplastic syndrome (n = 2), and hypogonadism (n = 4).

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  • (PMID = 19636009.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / UL1 RR024131; United States / NCRR NIH HHS / RR / 2MO1 RR0127
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Catecholamines; 0 / Chromogranin A; 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine
  • [Other-IDs] NLM/ PMC2734428
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3. Cheng SP, Saunders BD, Gauger PG, Doherty GM: Laparoscopic partial adrenalectomy for bilateral pheochromocytomas. Ann Surg Oncol; 2008 Sep;15(9):2506-8
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  • [Title] Laparoscopic partial adrenalectomy for bilateral pheochromocytomas.
  • BACKGROUND: Patients with hereditary pheochromocytoma are at risk of the development of bilateral disease.
  • Partial adrenalectomy can preserve adrenal function to avoid the morbidity associated with medical adrenal replacement.
  • METHODS: A 13-year-old patient with von Hippel-Lindau disease was found to have high urinary metanephrines and normetanephrines.
  • Computed tomography showed bilateral adrenal tumors (2.5 cm on the right side and 0.9 cm on the left).
  • MIBG scan showed positive uptake in the right adrenal gland without extra-adrenal uptake.
  • Intraoperative ultrasound was performed to determine the line of tumor excision, which was carefully planned to preserve most of the normal-appearing gland.
  • The main adrenal veins of both sides were precisely preserved.
  • Pathologic examination confirmed bilateral entirely excised pheochromocytomas.
  • CONCLUSION: Laparoscopic partial adrenalectomy for bilateral pheochromocytomas is safe and technically feasible.
  • It should be considered the treatment of choice for hereditary pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy. Pheochromocytoma / surgery
  • [MeSH-minor] Adolescent. Humans. Tomography, X-Ray Computed. von Hippel-Lindau Disease / complications

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  • (PMID = 18618188.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Sobue S, Hagiwara K, Banno Y, Tamiya-Koizumi K, Suzuki M, Takagi A, Kojima T, Asano H, Nozawa Y, Murate T: Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. J Neurochem; 2005 Nov;95(4):940-9
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  • [Title] Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12.
  • [MeSH-minor] Animals. Blotting, Western / methods. Brain / metabolism. Carbazoles / pharmacology. Chromatin Immunoprecipitation / methods. Electrophoretic Mobility Shift Assay / methods. Enzyme Inhibitors / pharmacology. Exons. Indole Alkaloids. Luciferases / metabolism. Mutagenesis / physiology. PC12 Cells. Pheochromocytoma / pathology. Promoter Regions, Genetic / physiology. Protein Binding / drug effects. Protein Binding / physiology. RNA, Messenger / metabolism. Rats. Reverse Transcriptase Polymerase Chain Reaction / methods. Transfection / methods

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  • (PMID = 16135093.001).
  • [ISSN] 0022-3042
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbazoles; 0 / Enzyme Inhibitors; 0 / Indole Alkaloids; 0 / RNA, Messenger; 0 / Sp1 Transcription Factor; 9061-61-4 / Nerve Growth Factor; 97161-97-2 / staurosporine aglycone; EC 1.13.12.- / Luciferases; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / sphingosine kinase
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5. Rajendra T, Kumar K, Liang LH: Hypertensive primary intraventricular hemorrhage due to a phaeochromocytoma. ANZ J Surg; 2006 Jul;76(7):664-7
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  • [Title] Hypertensive primary intraventricular hemorrhage due to a phaeochromocytoma.
  • Primary intraventricular haemorrhage (IVH) is rare.
  • We defined primary IVH as haemorrhage into the ventricles only as detected by computerized tomographic (CT) brain scan.
  • An adrenal phaeochromocytoma was diagnosed which was subsequently removed laparoscopically.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Cerebral Hemorrhage / etiology. Cerebral Ventricles. Hypertension / etiology. Pheochromocytoma / complications
  • [MeSH-minor] Blood Pressure. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed


6. Meredith LS, Eisenman DP, Green BL, Basurto-Dávila R, Cassells A, Tobin J: System factors affect the recognition and management of posttraumatic stress disorder by primary care clinicians. Med Care; 2009 Jun;47(6):686-94
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  • [Title] System factors affect the recognition and management of posttraumatic stress disorder by primary care clinicians.
  • BACKGROUND: Posttraumatic stress disorder (PTSD) is common with an estimated prevalence of 8% in the general population and up to 17% in primary care patients.
  • Yet, little is known about what determines primary care clinician's (PCC's) provision of PTSD care.
  • OBJECTIVE: To describe PCC's reported recognition and management of PTSD and identify how system factors affect the likelihood of performing clinical actions with regard to patients with PTSD or "PTSD treatment proclivity."
  • DESIGN: Linked cross-sectional surveys of medical directors and PCCs.
  • PARTICIPANTS: Forty-six medical directors and 154 PCCs in community health centers (CHCs) within a practice-based research network in New York and New Jersey.
  • MEASUREMENTS: Two system factors (degree of integration between primary care and mental health services, and existence of linkages with other community, social, and legal services) as reported by medical directors, and PCC reports of self-confidence, perceived barriers, and PTSD treatment proclivity.
  • RESULTS: Surveys from 47 (of 58) medical directors (81% response rate) and 154 PCCs (86% response rate).
  • PCCs from CHCs with better mental health integration reported greater confidence, fewer barriers, and higher PTSD treatment proclivity (all P < 0.05).
  • The PCCs in CHCs with better community linkages reported greater confidence, fewer barriers, higher PTSD treatment proclivity, and lower proclivity to refer patients to mental health specialists or to use a "watch and wait" approach (all P < 0.05).
  • CONCLUSIONS: System factors play an important role in PCC PTSD management.
  • Interventions are needed that restructure primary care practices by making mental health services more integrated and community linkages stronger.

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  • (PMID = 19433999.001).
  • [ISSN] 1537-1948
  • [Journal-full-title] Medical care
  • [ISO-abbreviation] Med Care
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / MH070683-01A1; United States / NIMH NIH HHS / MH / R34 MH070683; United States / NIMH NIH HHS / MH / R34 MH070683-01A1; United States / NIMH NIH HHS / MH / R34MH070683
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS114528; NLM/ PMC2762995
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7. Bellingham GA, Dhir AK, Luke PP: Case report: retroperitoneoscopic pheochromocytoma removal in an adult with Eisenmenger's syndrome. Can J Anaesth; 2008 May;55(5):295-301
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  • [Title] Case report: retroperitoneoscopic pheochromocytoma removal in an adult with Eisenmenger's syndrome.
  • PURPOSE: Patients with uncorrected or palliated, complex congenital heart lesions requiring surgery can benefit from laparoscopic techniques, but retroperitoneal insufflation may render them hemodynamically unstable.
  • We present a case of a pheochromocytoma removal via retroperitoneoscopy in a patient with a palliated, complex heart lesion.
  • CLINICAL FEATURES: A 28-yr-old woman was admitted for removal of a pheochromocytoma through retroperitoneoscopy.
  • The main feature of her heart disease was a complete atrioventricular canal defect.
  • She eventually developed Eisenmenger's syndrome and became chronically cyanotic.
  • Tumour manipulation led to systemic (and possibly pulmonary) hypertension, which exacerbated ventricular dysfunction.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Eisenmenger Complex / surgery. Insufflation / adverse effects. Pheochromocytoma / surgery. Retroperitoneal Space

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  • (PMID = 18451118.001).
  • [ISSN] 0832-610X
  • [Journal-full-title] Canadian journal of anaesthesia = Journal canadien d'anesthésie
  • [ISO-abbreviation] Can J Anaesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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8. Sobotka R, Komenda J, Bumba L, Tichy M: Photosystem II assembly in CP47 mutant of Synechocystis sp. PCC 6803 is dependent on the level of chlorophyll precursors regulated by ferrochelatase. J Biol Chem; 2005 Sep 9;280(36):31595-602
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  • [Title] Photosystem II assembly in CP47 mutant of Synechocystis sp. PCC 6803 is dependent on the level of chlorophyll precursors regulated by ferrochelatase.
  • Accumulation of chlorophyll and expression of the chlorophyll (Chl)-binding CP47 protein that serves as the core antenna of photosystem II are indispensable for the assembly of a functional photosystem II.
  • Similarly, supplementation of the CP47 mutant with the Chl precursor Mg-protoporphyrin IX increased the number of active photosystem-II centers, suggesting that synthesis of the mutated CP47 protein is enhanced by an increased Chl availability in the cell.
  • [MeSH-major] Chlorophyll / chemistry. Chlorophyll / metabolism. Ferrochelatase / physiology. Heme / metabolism. Light-Harvesting Protein Complexes / genetics. Light-Harvesting Protein Complexes / metabolism. Photosystem II Protein Complex / genetics. Photosystem II Protein Complex / metabolism. Protein Processing, Post-Translational. Synechocystis / genetics

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  • (PMID = 16027152.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Light-Harvesting Protein Complexes; 0 / Photosystem II Protein Complex; 127137-94-4 / photosystem II, chlorophyll-binding protein, CP-47; 1406-65-1 / Chlorophyll; 42VZT0U6YR / Heme; EC 4.99.1.1 / Ferrochelatase
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9. Li RG, Yu X, Zhao JD: [Expression and characterization of FNRD in cyanobacterium Synechococcus sp. PCC 7002]. Wei Sheng Wu Xue Bao; 2005 Oct;45(5):716-9
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  • [Title] [Expression and characterization of FNRD in cyanobacterium Synechococcus sp. PCC 7002].
  • PCC 7002, respectively.

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  • (PMID = 16342762.001).
  • [ISSN] 0001-6209
  • [Journal-full-title] Wei sheng wu xue bao = Acta microbiologica Sinica
  • [ISO-abbreviation] Wei Sheng Wu Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 1.18.1.2 / Ferredoxin-NADP Reductase
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10. Christmann C, Koeppe C, Braus DF, Ruf M, Flor H: A simultaneous EEG-fMRI study of painful electric stimulation. Neuroimage; 2007 Feb 15;34(4):1428-37
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  • Stimulus-correlated BOLD effects were found in the primary and secondary somatosensory areas (SI and SII), the operculum, the insula, the supplementary motor area (SMA proper), the cerebellum, and posterior parts of the anterior cingulate gyrus (ACC).
  • Higher unpleasantness rating was associated with suppression of activity in areas known to be involved in stimulus categorization and representation (ventral premotor cortex, PCC, parietal operculum, insula) and enhanced activation in areas initiating, propagating, and executing motor reactions (ACC, SMA proper, cerebellum, primary motor cortex).

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  • (PMID = 17178235.001).
  • [ISSN] 1053-8119
  • [Journal-full-title] NeuroImage
  • [ISO-abbreviation] Neuroimage
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Fujii M, Kawabata Y, Hayashi T, Nishimae H, Masuko S, Nosaka S: [Anesthetic management for laparoscopic resection of adrenal pheochromocytoma in a woman with chronic renal failure]. Masui; 2010 Mar;59(3):393-6
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  • [Title] [Anesthetic management for laparoscopic resection of adrenal pheochromocytoma in a woman with chronic renal failure].
  • A 52-year-old woman, undergoing hemodialysis for chronic renal failure over thirty years, developed pheochromocytoma.
  • Her serum concentrations of noradrenaline (NA) and adrenaline were 5,330 pg x ml(-1) and 212 pg x ml(-1), respectively.
  • Although hypotension occurred temporarily after CHDF, severe hemodynamic changes were not observed during operation owing to NA substitution and infusion of 5% plasma protein fraction, and the operation was finished uneventfully.
  • CHDF was useful for anesthetic management of a patient with adrenal pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Anesthesia, General. Kidney Failure, Chronic / complications. Laparoscopy. Perioperative Care. Pheochromocytoma / surgery


12. Stewart MF, Croft J, Reed P, New JP: Acute intermittent porphyria and phaeochromocytoma: shared features. J Clin Pathol; 2007 Aug;60(8):935-6
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  • [Title] Acute intermittent porphyria and phaeochromocytoma: shared features.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Pheochromocytoma / diagnosis. Porphyria, Acute Intermittent / diagnosis
  • [MeSH-minor] Adult. Catecholamines / urine. Diagnosis, Differential. Female. Humans. Hypertension / complications


13. Venkatesan AM, Locklin J, Dupuy DE, Wood BJ: Percutaneous ablation of adrenal tumors. Tech Vasc Interv Radiol; 2010 Jun;13(2):89-99
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  • [Title] Percutaneous ablation of adrenal tumors.
  • Adrenal tumors comprise a broad spectrum of benign and malignant neoplasms and include functional adrenal adenomas, pheochromocytomas, primary adrenocortical carcinoma, and adrenal metastases.
  • Percutaneous ablative approaches that have been described and used in the treatment of adrenal tumors include percutaneous radiofrequency ablation, cryoablation, microwave ablation, and chemical ablation.
  • Local tumor ablation in the adrenal gland presents unique challenges, secondary to the adrenal gland's unique anatomic and physiological features.
  • The results of clinical series employing percutaneous ablative techniques in the treatment of adrenal tumors are reviewed in this article.
  • Clinical and technical considerations unique to ablation in the adrenal gland are presented, including approaches commonly used in our practices, and risks and potential complications are discussed.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Catheter Ablation

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  • [Copyright] Published by Elsevier Inc.
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  • (PMID = 20540918.001).
  • [ISSN] 1557-9808
  • [Journal-full-title] Techniques in vascular and interventional radiology
  • [ISO-abbreviation] Tech Vasc Interv Radiol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CL999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
  • [Number-of-references] 69
  • [Other-IDs] NLM/ NIHMS199588; NLM/ PMC2886030
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14. Redondo Granado MJ, Torres Hinojal MC, Izquierdo López B: [Post viral onychomadesis outbreak in Valladolid]. An Pediatr (Barc); 2009 Nov;71(5):436-9
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  • [Transliterated title] Brote de onicomadesis posvírica en Valladolid.
  • INTRODUCTION: An onychomadesis outbreak associated with hand-foot-mouth disease (HFMD) was notified in winter 2008 in Valencia, Spain, with more than 200 people affected, the majority children.
  • Sixteen cases of post-viral onychomadesis post viral in Valladolid are presented MATERIAL AND METHODS: Between November 2008 and February 2009, 15 children aged between 18 months and 3 years, and one mother, presented with onychomadesis in Primary Care Centres in Valladolid.
  • Nine children (60%) had the clinical diagnosis of HFMD 3 to 12 weeks before (mean: 6 weeks), six with fever.
  • Perhaps the diagnosis is underestimated due to ignorance of the disease and the long interval between the acute viral process and nail shedding.
  • [MeSH-major] Disease Outbreaks. Hand, Foot and Mouth Disease / epidemiology. Nail Diseases / epidemiology. Nail Diseases / virology

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  • (PMID = 19819202.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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15. Timofeev KN, Kuznetsova GV, Elanskaya IV: Effects of dark adaptation on light-induced electron transport through photosystem I in the cyanobacterium Synechocystis sp. PCC 6803. Biochemistry (Mosc); 2005 Dec;70(12):1390-5
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  • [Title] Effects of dark adaptation on light-induced electron transport through photosystem I in the cyanobacterium Synechocystis sp. PCC 6803.
  • Kinetics of the redox reactions in the reaction center (P700) of photosystem I (PSI) of the cyanobacterium Synechocystis sp.
  • PCC 6803 have been studied by EPR spectroscopy.
  • [MeSH-major] Dark Adaptation / physiology. Electron Transport / physiology. Photosystem I Protein Complex / metabolism. Synechocystis / metabolism

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  • (PMID = 16417463.001).
  • [ISSN] 0006-2979
  • [Journal-full-title] Biochemistry. Biokhimii︠a︡
  • [ISO-abbreviation] Biochemistry Mosc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosystem I Protein Complex; 1406-65-1 / Chlorophyll; 53321-11-2 / chlorophyll P 700; 9I3SDS92WY / Diuron; IY9XDZ35W2 / Glucose; ZRH8M27S79 / Iodoacetamide
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16. Wang Q: Retraction statement. Effect of inhalational anesthetics on cytotoxicity and intracellular calcium differently in rat pheochromocytoma cells (PC12). J Huazhong Univ Sci Technolog Med Sci; 2008 Jun;28(3):372
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  • [Title] Retraction statement. Effect of inhalational anesthetics on cytotoxicity and intracellular calcium differently in rat pheochromocytoma cells (PC12).

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  • [RetractionOf] Wang Q, Li K, Yao S. J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):104-9 [18278471.001]
  • (PMID = 18807653.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Retraction of Publication
  • [Publication-country] China
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17. Ekman M, Jönhagen S, Hunsche E, Jönsson L: Burden of illness of chronic low back pain in Sweden: a cross-sectional, retrospective study in primary care setting. Spine (Phila Pa 1976); 2005 Aug 1;30(15):1777-85
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  • [Title] Burden of illness of chronic low back pain in Sweden: a cross-sectional, retrospective study in primary care setting.
  • STUDY DESIGN: Cross-sectional survey of patients with chronic low back pain in primary care setting.
  • OBJECTIVES: To analyze the health care resource use, productivity loss, and health-related quality of life of patients with chronic low back pain in Sweden.
  • SUMMARY OF BACKGROUND DATA: Despite the clinical and economic importance of chronic LBP, the overall burden of the disease is not well documented.
  • METHODS: Cross-sectional data on patients' socio-demographics, disease-related healthcare resource use during the past 6 months, inability to work during the previous 3 months, and quality of life at the time of the study visit were collected using questionnaires completed during an outpatient visit.
  • Patient recruitment and data collection was performed at 14 primary care centers in Sweden.
  • Direct and indirect costs were positively correlated with disease severity, disease duration, and female gender.
  • [MeSH-major] Cost of Illness. Health Care Costs. Low Back Pain / economics. Primary Health Care / economics
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Aged. Aged, 80 and over. Ambulatory Care / economics. Ambulatory Care / statistics & numerical data. Cross-Sectional Studies. Female. Humans. Linear Models. Male. Middle Aged. Multivariate Analysis. Retrospective Studies. Sweden

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  • (PMID = 16094281.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Korelusová J, Kasˇtovský J, Komárek J: HETEROGENEITY OF THE CYANOBACTERIAL GENUS SYNECHOCYSTIS AND DESCRIPTION OF A NEW GENUS, GEMINOCYSTIS(1). J Phycol; 2009 Aug;45(4):928-37
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  • [Title] HETEROGENEITY OF THE CYANOBACTERIAL GENUS SYNECHOCYSTIS AND DESCRIPTION OF A NEW GENUS, GEMINOCYSTIS(1).
  • The study and revision of the unicellular cyanobacterial genus Synechocystis was based on the type species S. aquatilis Sauv. and strain PCC 6803, a reference strain for this species.
  • Uniformity in rRNA gene sequence, morphology, and ultrastructure was observed in all available Synechocystis strains, with the exception of the strain PCC 6308, which has been considered by some to be a model strain for Synechocystis.
  • Because strain PCC 6308 was designated as a reference strain of the Synechocystis cluster 1 in Bergey's Manual, the members of this genetic cluster have to be revised and reclassified into Geminocystis gen. nov.
  • Only the members of the Synechocystis cluster 2 allied with PCC 6803 correspond both genetically and phenotypically to the type species of the genus Synechocystis (S. aquatilis).

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  • [Copyright] © 2009 Phycological Society of America.
  • (PMID = 27034224.001).
  • [ISSN] 0022-3646
  • [Journal-full-title] Journal of phycology
  • [ISO-abbreviation] J. Phycol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ EF555569/ EF555570/ EF555571
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; 16S rDNA / Cyanobacterium / Geminocystis / ITS / Synechocystis / phylogeny / taxonomy / thylakoids / ultrastructure
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19. Goh YS, Tong KL: Phaeochromocytoma the great mimicker: a case report. Ann Acad Med Singapore; 2008 Jan;37(1):79-81
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  • [Title] Phaeochromocytoma the great mimicker: a case report.
  • [MeSH-major] Pheochromocytoma / diagnosis
  • [MeSH-minor] Acute Coronary Syndrome / diagnosis. Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 18265905.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Singapore
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20. Knoop H, Zilliges Y, Lockau W, Steuer R: The metabolic network of Synechocystis sp. PCC 6803: systemic properties of autotrophic growth. Plant Physiol; 2010 Sep;154(1):410-22
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  • [Title] The metabolic network of Synechocystis sp. PCC 6803: systemic properties of autotrophic growth.
  • To obtain insight into the functional properties of phototrophic growth, we present a detailed reconstruction of the primary metabolic network of the autotrophic prokaryote Synechocystis sp. PCC 6803.


21. Jang SY, Yang DH, Lee SH, Kim JH, Park SH, Park HS, Cho Y, Chae SC, Jun JE, Park WH: Recurrent catecholamine-induced cardiomyopathy in a patient with a pheochromocytoma. Korean Circ J; 2009 Jun;39(6):254-7
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  • [Title] Recurrent catecholamine-induced cardiomyopathy in a patient with a pheochromocytoma.
  • Pheochromocytomas presents with variable clinical manifestations.
  • Cardiomyopathy caused by a pheochromocytoma is well known.
  • We report the case of a 62-year-old woman with recurrent left ventricular dysfunction, who was subsequently found to have a pheochromocytoma.
  • Patients with a cardiomyopathy, of non-specific origin, should have a pheochromocytoma ruled out.

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  • [Other-IDs] NLM/ PMC2771839
  • [Keywords] NOTNLM ; Cardiomyopathies / Catecholamines / Pheochromocytoma
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22. Drath M, Kloft N, Batschauer A, Marin K, Novak J, Forchhammer K: Ammonia triggers photodamage of photosystem II in the cyanobacterium Synechocystis sp. strain PCC 6803. Plant Physiol; 2008 May;147(1):206-15
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  • [Title] Ammonia triggers photodamage of photosystem II in the cyanobacterium Synechocystis sp. strain PCC 6803.
  • Here, we show that in the cyanobacterium Synechocystis sp. strain PCC 6803, ammonia triggers a rapid photodamage of photosystem II (PSII).
  • Whereas wild-type cells can cope with this damage by turning on the FtsH2-dependent PSII repair cycle, the FtsH2-deficient mutant is highly sensitive and loses PSII activity at millimolar concentration of ammonia.
  • Experiments with monochromatic light showed that ammonia-promoted PSII photoinhibition is executed by wavebands known to directly destroy the manganese cluster in the PSII oxygen-evolving complex, suggesting that the oxygen-evolving complex may be a direct target for ammonia toxicity.
  • [MeSH-major] Ammonia / pharmacology. Bacterial Proteins / metabolism. Light. Photosystem II Protein Complex / drug effects. Synechocystis / drug effects
  • [MeSH-minor] Nitrogen / metabolism. Quaternary Ammonium Compounds / metabolism

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  • (PMID = 18322144.001).
  • [ISSN] 0032-0889
  • [Journal-full-title] Plant physiology
  • [ISO-abbreviation] Plant Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Photosystem II Protein Complex; 0 / Quaternary Ammonium Compounds; 7664-41-7 / Ammonia; N762921K75 / Nitrogen
  • [Other-IDs] NLM/ PMC2330311
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23. Faria JF, Goldman SM, Szejnfeld J, Melo H, Kater C, Kenney P, Huayllas MP, Demarchi G, Francisco VV, Andreoni C, Srougi M, Ortiz V, Abdalla N: Adrenal masses: characterization with in vivo proton MR spectroscopy--initial experience. Radiology; 2007 Dec;245(3):788-97
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  • [Title] Adrenal masses: characterization with in vivo proton MR spectroscopy--initial experience.
  • PURPOSE: To prospectively determine the accuracy of in vivo proton ((1)H) magnetic resonance (MR) spectroscopy in distinguishing adrenal adenomas, pheochromocytomas, adrenocortical carcinomas, and metastases, with histologic or computed tomographic findings and follow-up data as the reference standards.
  • Sixty consecutive patients (24 male and 36 female patients; mean age, 53 years) harboring adrenal tumors larger than 2 cm in diameter (mean diameter, 4.6 cm +/- 3.4 [standard deviation]) entered the study and were examined with a 1.5-T MR imaging system and point-resolved multivoxel (1)H MR spectroscopy.
  • Thirty-eight patients had adenomas; 10, pheochromocytomas; five, carcinomas; and seven, metastases.
  • Metabolite ratios (choline-creatine, choline-lipid, lipid-creatine, and 4.0-4.3 ppm/creatine) and cutoff values (obtained by using receiver operating characteristic analyses) were obtained and compared for each type of adrenal mass, which was identified previously on the basis of clinical, hormonal, and pathologic evidence.
  • RESULTS: Cutoff values of 1.20 for the choline-creatine ratio (92% sensitivity, 96% specificity; P < .01), 0.38 for the choline-lipid ratio (92% sensitivity, 90% specificity; P < .01), and 2.10 for the lipid-creatine ratio (45% sensitivity, 100% specificity) enabled adenomas and pheochromocytomas to be distinguished from carcinomas and metastases.
  • A 4.0-4.3 ppm/creatine ratio greater than 1.50 enabled distinction of pheochromocytomas and carcinomas from adenomas and metastases (87% sensitivity, 98% specificity; P < .01).
  • CONCLUSION: (1)H MR spectroscopy can be used to characterize adrenal masses on the basis of spectral findings for benign adenomas, carcinomas, pheochromocytomas, and metastases.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Adrenocortical Carcinoma / diagnosis. Magnetic Resonance Spectroscopy. Pheochromocytoma / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prospective Studies. Reproducibility of Results

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  • [Copyright] (c) RSNA, 2007.
  • [CommentIn] Radiology. 2009 Mar;250(3):955-6; author reply 955-6; discussion 956 [19244058.001]
  • (PMID = 18024453.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Li G, Tang Z, Meng G, Dai K, Zhao J, Zheng X: Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120. Acta Crystallogr Sect F Struct Biol Cryst Commun; 2009 Oct 1;65(Pt 10):1039-41
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  • [Title] Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120.
  • To investigate the structure and function of OMTs, omt from Anabaena PCC 7120 was cloned into expression vector pET21a and expressed in a soluble form in Escherichia coli strain BL21 (DE3).

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  • (PMID = 19851017.001).
  • [ISSN] 1744-3091
  • [Journal-full-title] Acta crystallographica. Section F, Structural biology and crystallization communications
  • [ISO-abbreviation] Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.1.1.- / Methyltransferases
  • [Other-IDs] NLM/ PMC2765896
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25. Nakajo M, Yoshinaga K, Oriuchi N, Kinuya S, Yokoyama K, Yamaguchi T, Drafting Committee for Guideline of Internal Radiotherapy with 131I-MIBG, Japanese Society of Nuclear Medicine in Oncology and Immunology, Japanese Society of Nuclear Medicine: [Guideline draft of appropriate use of 131I-MIBG for internal radiotherapy of neuroendocrine tumors]. Kaku Igaku; 2008 Feb;45(1):suppl 1-40
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  • I3I-MIBG has been used for therapy of unresectable neuroendocrine tumors including malignant pheochromocytomas and neuroblastomas in foreign countries since the '80s when its clinical therapeutic trials were initiated.

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  • (PMID = 19594094.001).
  • [ISSN] 0022-7854
  • [Journal-full-title] Kaku igaku. The Japanese journal of nuclear medicine
  • [ISO-abbreviation] Kaku Igaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 35MRW7B4AD / 3-Iodobenzylguanidine
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26. Chien HP, Chang YS, Hsu PS, Lin JD, Wu YC, Chang HL, Chuang CK, Tsuei KH, Hsueh C: Adrenal cystic lesions: a clinicopathological analysis of 25 cases with proposed histogenesis and review of the literature. Endocr Pathol; 2008;19(4):274-81
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  • [Title] Adrenal cystic lesions: a clinicopathological analysis of 25 cases with proposed histogenesis and review of the literature.
  • Adrenal cystic lesions are uncommon and we analyzed clinical and pathologic features of 25 such cases from a single institute over 23 years.
  • The proposed mesothelial origin of adrenal epithelial cyst cannot be confirmed in our example.
  • Seven adrenal pseudocysts were associated with tumor, including two pheochromocytomas, one neuroblastoma, one adrenal cortical carcinoma, one adrenal cortical adenoma, one myelolipoma, and one schwannoma.
  • The distinction of true cystic lesion from cystic neoplasm is important and requires thorough sampling of the specimens.
  • [MeSH-major] Adrenal Gland Diseases / pathology. Adrenal Glands / pathology. Cysts / pathology

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  • (PMID = 18972224.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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27. Kaneko Y, Danev R, Nagayama K, Nakamoto H: Intact carboxysomes in a cyanobacterial cell visualized by hilbert differential contrast transmission electron microscopy. J Bacteriol; 2006 Jan;188(2):805-8
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  • Carboxysomes in rapidly frozen ice-embedded whole cells of the cyanobacterium Synechococcus sp. strain PCC 7942 were visualized by the recently developed Hilbert differential contrast transmission electron microscope.


28. Anouar Y, Yon L, Guillemot J, Thouennon E, Barbier L, Gimenez-Roqueplo AP, Bertherat J, Lefebvre H, Klein M, Muresan M, Grouzmann E, Plouin PF, Vaudry H, Elkahloun AG: Development of novel tools for the diagnosis and prognosis of pheochromocytoma using peptide marker immunoassay and gene expression profiling approaches. Ann N Y Acad Sci; 2006 Aug;1073:533-40
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  • [Title] Development of novel tools for the diagnosis and prognosis of pheochromocytoma using peptide marker immunoassay and gene expression profiling approaches.
  • Pheochromocytomas (PHEOs) are rare catecholamine-producing neoplasias that arise from chromaffin cells of the adrenal medulla or from extra-adrenal locations.
  • We have recently validated several assays for the measurement of peptides derived from chromogranin A (CgA) and secretogranin II (SgII) in order to determine whether these secreted neuroendocrine products could provide useful, complementary markers for the diagnosis and prognosis of PHEOs.
  • Both the CgA-derived peptide WE14 and the SgII-derived peptide EM66 proved to be sensitive circulating markers for the diagnosis of PHEO.
  • We have also initiated a comparative microarray study of benign and malignant PHEOs, which allowed the identification of a set of about 100 genes that were differentially expressed and best discriminated the two types of tumors.
  • A large majority of these genes were expressed at lower levels in the malignant disease and were associated with various characteristics of chromaffin cells, such as hormone secretion signaling and machinery, peptide maturation, and cellular morphology.
  • Altogether, these studies provide novel tools for the management of PHEO, and new insights for the understanding of tumorigenesis in chromaffin cells, which may offer potential therapeutic strategies.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Gene Expression Profiling. Pheochromocytoma / genetics


29. Wimpole JA, Adagra CF, Billson MF, Pillai DN, Foster DJ: Plasma free metanephrines in healthy cats, cats with non-adrenal disease and a cat with suspected phaeochromocytoma. J Feline Med Surg; 2010 Jun;12(6):435-40
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  • [Title] Plasma free metanephrines in healthy cats, cats with non-adrenal disease and a cat with suspected phaeochromocytoma.
  • Phaeochromocytomas are catecholamine-secreting tumours of the adrenal glands and are rare in cats.
  • Plasma metanephrine levels are widely considered the diagnostic test of choice for phaeochromocytoma in people but have not been investigated in cats.
  • In this study plasma free normetanephrine and metanephrine levels were measured using high-pressure liquid chromatography in healthy cats, sick cats with non-adrenal disease and in a cat with a suspected phaeochromocytoma.
  • Plasma normetanephrine was significantly higher in sick cats with non-adrenal disease compared to healthy cats (P<0.05) and markedly higher in the cat with a suspected phaeochromocytoma when compared to either group.
  • Plasma metanephrine was not significantly different in any of the groups.
  • This study establishes a first-line guide reference range for plasma metanephrine and normetanephrine levels in healthy cats and cats with non-adrenal disease.
  • These results provide rationale for further studies to establish the use of plasma normetanephrine levels as a potential diagnostic test for phaeochromocytoma in the cat.
  • [MeSH-major] Adrenal Gland Neoplasms / veterinary. Cat Diseases / blood. Cats / blood. Metanephrine / blood. Normetanephrine / blood. Pheochromocytoma / veterinary
  • [MeSH-minor] Adrenal Glands / radiography. Animals. Case-Control Studies. Chromatography, High Pressure Liquid / veterinary. Chronic Disease / epidemiology. Female. Lung Neoplasms / secondary. Male. Reference Values. Treatment Outcome

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  • [Copyright] Copyright 2009 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20159659.001).
  • [ISSN] 1532-2750
  • [Journal-full-title] Journal of feline medicine and surgery
  • [ISO-abbreviation] J. Feline Med. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0J45DE6B88 / Normetanephrine; 5001-33-2 / Metanephrine
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30. Denancé M, Guyot M, Samadi M: Short synthesis of 16beta-hydroxy-5alpha-cholestane-3,6-dione a novel cytotoxic marine oxysterol. Steroids; 2006 Jul;71(7):599-602
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  • Selective deoxygenation of primary alcohol of triol 6 has been accomplished in one step using Et(3)SiH and catalytic amount of B(C(6)F(5))(3) to produce compound 9 in high yield.
  • Oxidation of 11 with PCC, allowed the introduction of 3,6-ene-dione functionality, and further catalytic hydrogenation and deprotection furnished the 3,6-diketo steroid 1.

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  • (PMID = 16620894.001).
  • [ISSN] 0039-128X
  • [Journal-full-title] Steroids
  • [ISO-abbreviation] Steroids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 16-hydroxycholestane-3,6-dione; 0 / Cholestanones; 0 / Marine Toxins; K49P2K8WLX / Diosgenin
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31. Palomeras Vilches A, Picas Jufresa A, Buñuel Alvarez JC, Gassen C: [Descriptive study of a polymyalgia rheumatica case series in a Primary Care Centre]. Aten Primaria; 2010 Jan;42(1):57-8
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  • [Title] [Descriptive study of a polymyalgia rheumatica case series in a Primary Care Centre].
  • [Transliterated title] Estudio descriptivo de una serie de casos de polimialgia reumática controlados en un centro de atención primaria.

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  • (PMID = 19467733.001).
  • [ISSN] 0212-6567
  • [Journal-full-title] Atencion primaria
  • [ISO-abbreviation] Aten Primaria
  • [Language] SPA
  • [Publication-type] Letter
  • [Publication-country] Spain
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32. Choi I, Campbell KH: Treatment of ovine oocytes with caffeine increases the accessibility of DNase I to the donor chromatin and reduces apoptosis in somatic cell nuclear transfer embryos. Reprod Fertil Dev; 2010;22(6):1000-14
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  • Caffeine treatment of ovine oocytes increases the activity of maturation-promoting factor (MPF) and mitogen-activated protein kinases (MAPKs) and, in somatic cell nuclear transfer (SCNT) embryos, increases the frequency of nuclear envelope breakdown (NEBD) and premature chromosome condensation (PCC).
  • One explanation for this is that NEBD and PCC release chromatin-bound somatic factors, allowing greater access of oocyte factors involved in DNA synthesis and nuclear reprogramming to donor chromatin.

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  • (PMID = 20591334.001).
  • [ISSN] 1031-3613
  • [Journal-full-title] Reproduction, fertility, and development
  • [ISO-abbreviation] Reprod. Fertil. Dev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Chromatin; 3G6A5W338E / Caffeine; EC 3.1.21.1 / Deoxyribonuclease I
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33. Kufryk GI, Vermaas WF: Sll1717 affects the redox state of the plastoquinone pool by modulating quinol oxidase activity in thylakoids. J Bacteriol; 2006 Feb;188(4):1286-94
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  • A Synechocystis sp. strain PCC 6803 mutant lacking CtaI, a main subunit of cytochrome c oxidase, is not capable of growing at light intensities below 5 micromol photons m(-2) s(-1), presumably due to an overreduced plastoquinone pool in the thylakoid membrane.
  • Sll1717 appears to be unique to Synechocystis sp. strain PCC 6803 and has a close homologue encoded in the genome of this organism.
  • [MeSH-major] Bacterial Proteins / physiology. Electron Transport Complex IV / metabolism. Oxidoreductases / metabolism. Plastoquinone / metabolism. Synechocystis / metabolism. Thylakoids / metabolism

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  • (PMID = 16452410.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 86-01-1 / Guanosine Triphosphate; 8L70Q75FXE / Adenosine Triphosphate; EC 1.- / Oxidoreductases; EC 1.- / duroquinol oxidase; EC 1.9.3.1 / Electron Transport Complex IV; OAC30J69CN / Plastoquinone
  • [Other-IDs] NLM/ PMC1367235
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34. Castillo OA, Vitagliano G, Cortes O, Kerkebe M, Pinto I, Arellano L: Bilateral laparoscopic adrenalectomy. J Endourol; 2007 Sep;21(9):1053-8
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  • BACKGROUND AND PURPOSE: Laparoscopic adrenalectomy has become the gold standard in the surgical management of adrenal pathology.
  • Bilateral adrenalectomy is indicated in patients with Cushing's disease secondary to macroadenoma or hypophysial hyperplasia in whom medical treatment and transsphenoid surgery have failed.
  • There were 6 cases of bilateral pheochromocytoma, 6 patients with Cushing's disease, 3 cases of metastasis, 3 congenital adrenal hyperplasias, 2 hyperaldosteronisms, and a single case each of adrenal adenoma and myelolipoma.
  • The mean tumor size was 4.15 cm (range 1-11 cm).

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  • (PMID = 17941786.001).
  • [ISSN] 0892-7790
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Moxon KA, Hallman S, Aslani A, Kalkhoran NM, Lelkes PI: Bioactive properties of nanostructured porous silicon for enhancing electrode to neuron interfaces. J Biomater Sci Polym Ed; 2007;18(10):1263-81
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  • Since the extracellular matrix consists of nanostructured fibrous protein assemblies, we have postulated that neurons may prefer a more complex surface structure than the smooth surface typical of thin-film microelectrodes.
  • We, therefore, investigated the suitability of a nanoporous silicon surface layer to increase the biocompatibility of our thin film ceramic-insulated multisite electrodes.
  • In vitro testing demonstrated increased extension of neurites from PC12 pheochromocytoma cells on porous silicon surfaces compared to smooth silicon surfaces.

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  • (PMID = 17939885.001).
  • [ISSN] 0920-5063
  • [Journal-full-title] Journal of biomaterials science. Polymer edition
  • [ISO-abbreviation] J Biomater Sci Polym Ed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biocompatible Materials; Z4152N8IUI / Silicon
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36. Lee BD, Apel WA, Walton MR: Calcium carbonate formation by Synechococcus sp. strain PCC 8806 and Synechococcus sp. strain PCC 8807. Bioresour Technol; 2006 Dec;97(18):2427-34
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  • [Title] Calcium carbonate formation by Synechococcus sp. strain PCC 8806 and Synechococcus sp. strain PCC 8807.
  • Synechococcus sp. strain PCC 8806 and Synechococcus sp. strain PCC 8807 were tested in microcosm experiments for their ability to calcify when exposed to a fixed calcium concentration of 3.4 mM and dissolved inorganic carbon concentrations of 0.5, 1.25 and 2.5 mM.
  • Synechococcus sp. strain PCC 8806 removed calcium continuously over the duration of the experiment producing approximately 18.6 mg of solid phase calcium.
  • Calcium removal occurred over a two-day time period when Synechococcus sp. strain PCC 8807 was tested and only 8.9 mg of solid phase calcium was produced.
  • Creation of an alkaline growth environment catalyzed by the physiology of the cyanobacteria appeared to be the primary factor responsible for CaCO3 precipitation in these experiments.
  • [MeSH-minor] Bicarbonates / pharmacology. Calcium / metabolism. Carbon Dioxide / metabolism. Chemical Precipitation. Hydrogen-Ion Concentration

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  • (PMID = 16289626.001).
  • [ISSN] 0960-8524
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bicarbonates; 142M471B3J / Carbon Dioxide; H0G9379FGK / Calcium Carbonate; SY7Q814VUP / Calcium
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37. Bornstein SR, Gimenez-Roqueplo AP: Genetic testing in pheochromocytoma: increasing importance for clinical decision making. Ann N Y Acad Sci; 2006 Aug;1073:94-103
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  • [Title] Genetic testing in pheochromocytoma: increasing importance for clinical decision making.
  • Hereditary pheochromocytomas and paragangliomas are caused by germline mutations in syndrome-associated genes.
  • This includes multiple endocrine neoplasia Type 2 (MEN 2) caused by mutations in the RET proto-oncogene, von Hippel-Lindau (VHL) syndrome due to mutations of the VHL gene, neurofibromatosis Type I (NF1) caused by mutations of the NF1 gene, and pheochromocytoma/paraganglioma syndromes due to mutations in genes encoding the succinate dehydrogenase subunits D (SDHD) and B (SDHB).
  • At the First International Symposium on Pheochromocytoma (ISP2005) organized by the National Institutes of Health, a panel of specialist clinicians and scientists from around the world addressed the topic of genetic testing in pheochromocytoma patients.
  • A pragmatic algorithm is presented, taking into account patient age, tumor location (extra-adrenal, intra-adrenal, unilateral, and bilateral), biochemical presentation, and financial costs.
  • This was based on cumulative frequencies ranging from 7.5% to 29% for germline mutations in four genes (RET, VHL, SDHB, and SDHD) in patients with apparently sporadic pheochromocytomas.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genetic Testing. Pheochromocytoma / genetics. Practice Patterns, Physicians'
  • [MeSH-minor] Genetic Predisposition to Disease. Humans


38. Dingemans MM, van den Berg M, Bergman A, Westerink RH: Calcium-related processes involved in the inhibition of depolarization-evoked calcium increase by hydroxylated PBDEs in PC12 cells. Toxicol Sci; 2010 Apr;114(2):302-9
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  • An example is the OH-PBDE-induced increase of basal intracellular Ca(2+) concentration ([Ca(2+)](i)) by release of Ca(2+) from endoplasmic reticulum (ER) and mitochondria and/or influx of extracellular Ca(2+).
  • Therefore, effects of (OH-)PBDEs on the depolarization-evoked (100 mM K(+)) net increase in [Ca(2+)](i) (depolarization-evoked [Ca(2+)](i)) were measured in neuroendocrine pheochromocytoma cells using the Ca(2+)-responsive dye Fura-2.
  • Especially at higher concentrations of OH-PBDEs (5-20 microM), large increases in basal [Ca(2+)](i) strongly inhibited depolarization-evoked [Ca(2+)](i).

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  • (PMID = 20044592.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels, L-Type; 0 / Environmental Pollutants; 0 / Flame Retardants; 0 / Halogenated Diphenyl Ethers; SY7Q814VUP / Calcium; TSN3DL106G / Fura-2
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39. Shifrin AL, Xenachis C, Fay A, Matulewicz TJ, Kuo YH, Vernick JJ: One hundred and seven family members with the rearranged during transfection V804M proto-oncogene mutation presenting with simultaneous medullary and papillary thyroid carcinomas, rare primary hyperparathyroidism, and no pheochromocytomas: is this a new syndrome--MEN 2C? Surgery; 2009 Dec;146(6):998-1005
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  • [Title] One hundred and seven family members with the rearranged during transfection V804M proto-oncogene mutation presenting with simultaneous medullary and papillary thyroid carcinomas, rare primary hyperparathyroidism, and no pheochromocytomas: is this a new syndrome--MEN 2C?
  • BACKGROUND: The rearranged during transfection (RET) V804M proto-oncogene mutation is rare and associated with medullary thyroid carcinoma (MTC).
  • METHODS: Family members were tested for RET mutations, calcitonin levels, and screened for pheochromocytoma and primary hyperparathyroidism (PHPT).
  • There were no findings of pheochromocytoma.
  • The second generation experienced earlier disease development; onset occurred earliest in the third generation.
  • However, it does not fit the classic familial MTC or MEN 2A cancer syndrome.
  • Considering that PTC is not an incidental finding, but the result of an inherited RET V804 M mutation, we propose to identify this phenotypic expression as a unique syndrome consistent with manifestations of MTC, PHPT, and PTC.
  • [MeSH-major] Carcinoma, Medullary / genetics. Carcinoma, Papillary / genetics. Hyperparathyroidism, Primary / genetics. Multiple Endocrine Neoplasia / genetics. Point Mutation. Proto-Oncogene Proteins c-ret / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adrenal Gland Neoplasms / genetics. Adult. Aged. Aged, 80 and over. Amino Acid Substitution. Anticipation, Genetic. Female. Humans. Italy. Male. Middle Aged. Pedigree. Penetrance. Pheochromocytoma / genetics. Proto-Oncogenes. Retrospective Studies. Syndrome


40. Agha A, Hornung M, Iesalnieks I, Glockzin G, Schlitt HJ: Single-incision retroperitoneoscopic adrenalectomy and single-incision laparoscopic adrenalectomy. J Endourol; 2010 Nov;24(11):1765-70
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  • OBJECTIVE: Single-incision surgery is by now practicable in many fields of surgery, including surgery of the adrenal gland.
  • RESULTS: All patients had benign adrenal tumors (Conn's adenoma, n = 7; pheochromocytoma, n = 1).
  • Tumor size ranged between 1.2 and 2.4 cm.

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  • (PMID = 20849304.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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41. Bolhuis H, Severin I, Confurius-Guns V, Wollenzien UI, Stal LJ: Horizontal transfer of the nitrogen fixation gene cluster in the cyanobacterium Microcoleus chthonoplastes. ISME J; 2010 Jan;4(1):121-30
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  • In this study, we show that a complete nif-gene cluster is present in the genome of M. chthonoplastes PCC 7420 and that the three structural nitrogenase genes, nifHDK, are present in a collection of axenic strains of M. chthonoplastes from distant locations.
  • In this study, we provide evidence that the nif operon of M. chthonoplastes is acquired through horizontal gene transfer.
  • Moreover, the presence of the same nif-cluster in M. chthonoplastes isolates derived from various sites around the world suggests that this horizontal gene transfer event must have occurred early in the evolution of M. chthonoplastes.
  • We have been unable to express nitrogenase in cultures of M. chthonoplastes, but we show that these genes were expressed under natural conditions in the field.

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  • (PMID = 19741736.001).
  • [ISSN] 1751-7370
  • [Journal-full-title] The ISME journal
  • [ISO-abbreviation] ISME J
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ GQ397255/ GQ397256/ GQ397257/ GQ397258/ GQ397259/ GQ397260/ GQ397261/ GQ397262/ GQ397263/ GQ397264/ GQ397265/ GQ397266/ GQ397267/ GQ397268/ GQ397269/ GQ397270/ GQ397271/ GQ397272/ GQ397273/ GQ397274/ GQ402014/ GQ402015/ GQ402016/ GQ402017/ GQ402018/ GQ402019/ GQ402020/ GQ402021/ GQ402022/ GQ402023/ GQ402024/ GQ402025/ GQ402026
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA, Bacterial; EC 1.- / Oxidoreductases; EC 1.18.6.1 / nitrogenase reductase
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42. Frewin CL, Jaroszeski M, Weeber E, Muffly KE, Kumar A, Peters M, Oliveros A, Saddow SE: Atomic force microscopy analysis of central nervous system cell morphology on silicon carbide and diamond substrates. J Mol Recognit; 2009 Sep-Oct;22(5):380-8
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  • Brain machine interface (BMI) devices offer a platform that can be used to assist people with extreme disabilities, such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease.
  • H4 human neuroglioma and PC12 rat pheochromocytoma cell lines were used for the study, and polystyrene (PSt) and amorphous glass were used as controls or for morphological comparison.
  • [MeSH-major] Carbon Compounds, Inorganic / pharmacology. Cell Survival / drug effects. Central Nervous System / drug effects. Central Nervous System / pathology. Diamond / pharmacology. Neurons / drug effects. Silicon Compounds / pharmacology
  • [MeSH-minor] Animals. Cell Line, Tumor. Humans. Microscopy, Atomic Force. PC12 Cells. Rats

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  • [Copyright] Copyright (c) 2009 John Wiley & Sons, Ltd.
  • (PMID = 19585542.001).
  • [ISSN] 1099-1352
  • [Journal-full-title] Journal of molecular recognition : JMR
  • [ISO-abbreviation] J. Mol. Recognit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbon Compounds, Inorganic; 0 / Silicon Compounds; 7782-40-3 / Diamond; WXQ6E537EW / silicon carbide
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43. Waldmann J, Bartsch DK, Kann PH, Fendrich V, Rothmund M, Langer P: Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening. Langenbecks Arch Surg; 2007 Jul;392(4):437-43
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  • [Title] Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening.
  • BACKGROUND: Adrenal tumors are a common manifestation of the multiple endocrine neoplasia type 1 (MEN-1) syndrome.
  • Adrenal glands have been screened by biochemical analysis and either by endoscopic ultrasound (EUS) or computed tomography (CT) or both.
  • Age at diagnosis of MEN-1, type of adrenal tumor, genotype, therapy, and clinical characteristics have been analyzed.
  • RESULTS: In 21 (55%) patients, adrenal involvement of the disease was detected.
  • Adrenal lesions were detected in average 6.9 years after the initial diagnosis of MEN-1.
  • Median tumor size was 12 mm (5-40 mm).
  • Tumor size smaller than 10 mm was observed in 11 patients.
  • Twelve patients had unilateral while nine had bilateral adrenal lesions.
  • EUS detected all adrenal tumors, whereas CT failed in seven cases.
  • In three patients, functioning tumors (one pheochromocytoma, one bilateral Cushing adenoma, and one adrenocortical carcinoma) and one nonfunctioning adenoma were diagnosed by histology and biochemical assessment.
  • Nonfunctioning adrenal lesions, not characterized by histology yet, were found in 18 patients.
  • There was no statistical difference with regard to adrenal involvement between patients with germline mutations in exons 2 and 10 (12/21) and those with mutations in exons 3-9 (6/11).
  • CONCLUSION: MEN-1-associated adrenal tumors are mostly small, benign, and nonfunctioning and much more common than previously reported.
  • [MeSH-major] Adrenal Gland Neoplasms. Multiple Endocrine Neoplasia Type 1

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  • (PMID = 17235589.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Qi Q, Hao M, Ng WO, Slater SC, Baszis SR, Weiss JD, Valentin HE: Application of the Synechococcus nirA promoter to establish an inducible expression system for engineering the Synechocystis tocopherol pathway. Appl Environ Microbiol; 2005 Oct;71(10):5678-84
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  • Recent efforts to analyze and engineer tocopherol biosynthesis led to the identification of Synechocystis sp. strain PCC 6803 as a well-characterized model system.
  • To facilitate the identification of the rate-limiting step(s) in the tocopherol biosynthetic pathway through the modulation of transgene expression, we established an inducible expression system in Synechocystis sp. strain PCC 6803.
  • The nirA promoter from Synechococcus sp. strain PCC 7942, which is repressed by ammonium and induced by nitrite (S.-I.
  • The culture supernatant of these cultures exhibited a brown coloration, a finding indicative of homogentisic acid excretion.
  • These data demonstrate that the nirA promoter can be used to control transgene expression in Synechocystis and that homogentisic acid is a limiting factor for tocopherol synthesis in Synechocystis sp. strain PCC 6803.

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  • (PMID = 16204475.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arabidopsis Proteins; 1406-66-2 / Tocopherols; EC 1.13.11.27 / 4-Hydroxyphenylpyruvate Dioxygenase; EC 1.7.- / Nitrite Reductases; EC 1.7.2.1 / nitrite reductase, copper-containing
  • [Other-IDs] NLM/ PMC1265929
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45. Higo A, Suzuki T, Ikeuchi M, Ohmori M: Dynamic transcriptional changes in response to rehydration in Anabaena sp. PCC 7120. Microbiology; 2007 Nov;153(Pt 11):3685-94
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  • [Title] Dynamic transcriptional changes in response to rehydration in Anabaena sp. PCC 7120.
  • Global transcriptional responses to dehydration and rehydration were determined in Anabaena sp. PCC 7120.
  • We conclude that rehydration is a complex process in which the expression of certain genes, particularly those for metabolism, is dramatically induced.

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  • (PMID = 17975076.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 059QF0KO0R / Water
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46. Osanai T, Imamura S, Asayama M, Shirai M, Suzuki I, Murata N, Tanaka K: Nitrogen induction of sugar catabolic gene expression in Synechocystis sp. PCC 6803. DNA Res; 2006 Oct 31;13(5):185-95
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  • [Title] Nitrogen induction of sugar catabolic gene expression in Synechocystis sp. PCC 6803.
  • Here, using microarray analysis, we investigated changes in transcript profiles following nitrogen depletion in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  • Results revealed that genes for sugar catabolic pathways including glycolysis, oxidative pentose phosphate (OPP) pathway, and glycogen catabolism were induced by nitrogen depletion, and activities of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), two key enzymes of the OPP pathway, were demonstrated to increase under this condition.
  • Since these nitrogen activations were abolished in an ntcA mutant, and since these genes were not directly included in the NtcA regulon, we suggested that sugar catabolic genes were induced by nitrogen depletion under complex and redundant regulations including SigE and other unknown factor(s) under the control of NtcA.
  • [MeSH-minor] Bacterial Proteins / genetics. Bacterial Proteins / metabolism. Base Sequence. DNA, Bacterial / genetics. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Gene Expression Profiling. Gene Expression Regulation, Bacterial. Glycogenolysis / genetics. Glycolysis / genetics. Models, Biological. Mutation. Oligonucleotide Array Sequence Analysis. Pentose Phosphate Pathway / genetics. Transcription Factors / genetics. Transcription Factors / metabolism

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  • (PMID = 17046957.001).
  • [ISSN] 1340-2838
  • [Journal-full-title] DNA research : an international journal for rapid publication of reports on genes and genomes
  • [ISO-abbreviation] DNA Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA, Bacterial; 0 / DNA-Binding Proteins; 0 / Transcription Factors; 147785-30-6 / ntcA protein, Synechococcus; N762921K75 / Nitrogen
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47. Pigny P, Cardot-Bauters C: Genetics of pheochromocytoma and paraganglioma: new developments. Ann Endocrinol (Paris); 2010 Mar;71(2):76-82
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  • [Title] Genetics of pheochromocytoma and paraganglioma: new developments.
  • Since 2000, several new susceptibility genes for hereditary pheochromocytoma or paraganglioma have been discovered.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / genetics. Paraganglioma / diagnosis. Paraganglioma / genetics. Pheochromocytoma / diagnosis. Pheochromocytoma / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Genetic Predisposition to Disease. Genetic Testing. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neovascularization, Pathologic / genetics. Neural Crest / growth & development. Young Adult

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20031114.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 31
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48. Cox K, Britten N, Hooper R, White P: Patients' involvement in decisions about medicines: GPs' perceptions of their preferences. Br J Gen Pract; 2007 Oct;57(543):777-84
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  • BACKGROUND: Patients vary in their desire to be involved in decisions about their care.
  • SETTING: Five primary care centres in south London.
  • Thirty-nine per cent of these patients wanted their GPs to share the decision, 45% wanted the GP to be the main (28%) or only (17%) decision maker regarding their care, and 16% wanted to be the main (14%) or only (2%) decision maker themselves.

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  • (PMID = 17925134.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2151809
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49. Sato H, Fujimori T, Sonoike K: sll1961 is a novel regulator of phycobilisome degradation during nitrogen starvation in the cyanobacterium Synechocystis sp. PCC 6803. FEBS Lett; 2008 Apr 2;582(7):1093-6
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  • [Title] sll1961 is a novel regulator of phycobilisome degradation during nitrogen starvation in the cyanobacterium Synechocystis sp. PCC 6803.
  • The sll1961 gene was reported to encode a regulatory factor of photosystem stoichiometry in the cyanobacterium Synechocystis sp. PCC 6803.
  • The results indicate the presence of a novel pathway for phycobilisome degradation control independent of nblA expression.

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  • (PMID = 18325343.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Phycobilisomes; 0 / RNA, Messenger; 0 / nblA protein, Synechocystis; N762921K75 / Nitrogen
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50. Pecina-Slaus N, Nikuseva-Martic T, Gall-Troselj K, Radic K, Hrascan R: Replication error-positive samples found in pheochromocytomas. In Vivo; 2005 Mar-Apr;19(2):359-65
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  • [Title] Replication error-positive samples found in pheochromocytomas.
  • Adenomatous polyposis coli, (APC) and E-cadherin (CDH1) tumor suppressor genes were investigated in human pheochromocytoma.
  • MATERIALS AND METHODS: Fifteen sporadic pheochromocytomas were tested for gene instability by PCR/loss of heterozygosity.
  • Detection of c-myc protein was performed using immunohistochemistry.
  • Immunohistochemistry showed increased levels of c-myc in comparison to normal adrenal tissue.
  • CONCLUSION: Our results suggest that microsatellite genetic instabilities of the E-cadherin gene have a role in pheochromocytoma development and progression.
  • Detected instability indicates that mismatch repair may be targeted in pheochromocytoma.
  • Increased expression of c-myc protein as well as allelic imbalances of APC and CDH 1 genes suggest that the wnt signalling pathway may have a role in this malignancy.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Cadherins / genetics. Genes, APC. Genomic Instability. Pheochromocytoma / genetics
  • [MeSH-minor] Adult. Aged. DNA, Neoplasm / genetics. Female. Humans. Loss of Heterozygosity. Male. Middle Aged. Proto-Oncogene Proteins c-myc / biosynthesis

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  • (PMID = 15796198.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cadherins; 0 / DNA, Neoplasm; 0 / Proto-Oncogene Proteins c-myc
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51. Miller C, Elkas JC: Conservative management of extra-adrenal pheochromocytoma during pregnancy. Obstet Gynecol; 2005 Oct;106(4):868
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  • [Title] Conservative management of extra-adrenal pheochromocytoma during pregnancy.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Pheochromocytoma / therapy. Pregnancy Complications, Neoplastic / therapy


52. Liu GQ, Zeng ZP, Li HZ, Fan XR, Liu DM, Tong AL, Zheng X, Liu C: [Expression of urotensin II and G-protein coupled receptor 14 mRNA in human pheochromocytoma tissues]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2005 Aug;27(4):457-60
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  • [Title] [Expression of urotensin II and G-protein coupled receptor 14 mRNA in human pheochromocytoma tissues].
  • OBJECTIVE: To investigate the expression of urotensin II (U II) and G-protein coupled receptor 14 (GPR14) mRNA in human pheochromocytoma tissues.
  • METHODS: Total RNA from normal adrenal and pheochromocytoma tissues was extracted.
  • The reverse transcription-polymerase chain reaction method was used to evaluate the levels of U II and GPR14 mRNA expression in human pheochromocytoma tissues.
  • RESULTS: There was no significant difference of U II and GPR14 mRNA expression between normal adrenal cortex and medulla.
  • The expression of U II and GPR14 mRNA in pheochromocytoma was significantly lower than that in normal adrenal cortex and medulla (P < 0.05).
  • The expression of GPR14 mRNA in adrenal pheochromocytomas was significantly lower than that of extra-adrenal pheochromocytomas (P < 0.05).
  • CONCLUSION: U II and GPR14 may play a role in the pathogenesis and hypertension regulating of pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Pheochromocytoma / metabolism. Receptors, G-Protein-Coupled / biosynthesis. Urotensins / biosynthesis
  • [MeSH-minor] Adrenal Cortex / metabolism. Adrenal Medulla / metabolism. Humans. RNA, Messenger / biosynthesis. RNA, Messenger / genetics

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  • (PMID = 16178439.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, G-Protein-Coupled; 0 / UTS2R protein, human; 0 / Urotensins; 9047-55-6 / urotensin II
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53. Fiedler B, Börner T, Wilde A: Phototaxis in the cyanobacterium Synechocystis sp. PCC 6803: role of different photoreceptors. Photochem Photobiol; 2005 Nov-Dec;81(6):1481-8
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  • [Title] Phototaxis in the cyanobacterium Synechocystis sp. PCC 6803: role of different photoreceptors.
  • PCC 6803 was suggested as a part of a light-stimulated signal transduction chain inhibiting movement toward blue light.
  • Analysis of mutants lacking cysteine-129 in the N-terminal chromophore binding domain indicated that this domain is also important for Cph2 function or folding of the protein.
  • PCC 6803 genome were inactivated in wild-type and cph2 knockout mutant background.

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  • (PMID = 16354116.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Cph2 protein, bacteria; 0 / Cryptochromes; 0 / Flavoproteins; 0 / Photoreceptors, Microbial; 11121-56-5 / Phytochrome
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54. Suh IW, Lee CW, Kim YH, Hong MK, Lee JW, Kim JJ, Park SW, Park SJ: Catastrophic catecholamine-induced cardiomyopathy mimicking acute myocardial infarction, rescued by extracorporeal membrane oxygenation (ECMO) in pheochromocytoma. J Korean Med Sci; 2008 Apr;23(2):350-4
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  • [Title] Catastrophic catecholamine-induced cardiomyopathy mimicking acute myocardial infarction, rescued by extracorporeal membrane oxygenation (ECMO) in pheochromocytoma.
  • Pheochromocytoma is a rare disorder and functioning tumor composed of chromaffin cells that secrete catecholamines.
  • Patients with a pheochromocytoma 'crisis' have a high mortality in spite of aggressive therapy.
  • We present a case with a severe acute catecholamine cardiomyopathy presenting ST segment elevation with cardiogenic shock after hemorrhage into a left suprarenal tumor.
  • [MeSH-major] Cardiomyopathies / diagnosis. Cardiomyopathies / etiology. Catecholamines / adverse effects. Extracorporeal Membrane Oxygenation / methods. Myocardial Infarction / diagnosis. Pheochromocytoma / therapy
  • [MeSH-minor] Adrenal Glands / pathology. Adult. Coronary Angiography / methods. Diagnosis, Differential. Electrocardiography / methods. Humans. Intra-Aortic Balloon Pumping. Male. Time Factors. Tomography, X-Ray Computed / methods


55. Ni S, Benning MM, Smola MJ, Feldmann EA, Kennedy MA: Crystal structure of Npun_R1517, a putative negative regulator of heterocyst differentiation from Nostoc punctiforme PCC 73102. Proteins; 2009 Feb 15;74(3):794-8
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  • [Title] Crystal structure of Npun_R1517, a putative negative regulator of heterocyst differentiation from Nostoc punctiforme PCC 73102.

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  • (PMID = 19089958.001).
  • [ISSN] 1097-0134
  • [Journal-full-title] Proteins
  • [ISO-abbreviation] Proteins
  • [Language] eng
  • [Databank-accession-numbers] PDB/ 3E56
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins
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56. Di Donato M, Cohen RO, Diner BA, Breton J, van Grondelle R, Groot ML: Primary charge separation in the photosystem II core from Synechocystis: a comparison of femtosecond visible/midinfrared pump-probe spectra of wild-type and two P680 mutants. Biophys J; 2008 Jun;94(12):4783-95
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  • [Title] Primary charge separation in the photosystem II core from Synechocystis: a comparison of femtosecond visible/midinfrared pump-probe spectra of wild-type and two P680 mutants.
  • It is now quite well accepted that charge separation in PS2 reaction centers starts predominantly from the accessory chlorophyll B(A) and not from the special pair P(680).
  • To identify spectral signatures of B(A,) and to further clarify the process of primary charge separation, we compared the femtosecond-infrared pump-probe spectra of the wild-type (WT) PS2 core complex from the cyanobacterium Synechocystis sp.
  • PCC 6803 with those of two mutants in which the histidine residue axially coordinated to P(B) (D2-His(197)) has been changed to Ala or Gln.
  • By analogy with the structure of purple bacterial reaction centers, the mutated histidine is proposed to be indirectly H-bonded to the C(9)=O carbonyl of the putative primary donor B(A) through a water molecule.
  • In addition, a comparison of the time-resolved visible/midinfrared spectra of the WT and mutants has allowed us to investigate the changes in the kinetics of primary charge separation induced by the mutations and to propose a band assignment identifying the characteristic vibrations of B(A).
  • [MeSH-major] Photosystem II Protein Complex / chemistry. Photosystem II Protein Complex / radiation effects. Synechocystis / metabolism

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  • (PMID = 18326665.001).
  • [ISSN] 1542-0086
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosystem II Protein Complex; 0 / Protons
  • [Other-IDs] NLM/ PMC2397376
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57. Allakhverdiev SI, Los DA, Mohanty P, Nishiyama Y, Murata N: Glycinebetaine alleviates the inhibitory effect of moderate heat stress on the repair of photosystem II during photoinhibition. Biochim Biophys Acta; 2007 Dec;1767(12):1363-71
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  • PCC 7942 cells to accumulate glycinebetaine when choline is supplemented exogenously.
  • First, we observed two types of protective effect of glycinebetaine against heat-induced inactivation of photosystem II (PSII) in darkness; the codA transgene shifted the temperature range of inactivation of the oxygen-evolving complex from 40-52 degrees C (with half inactivation at 46 degrees C) to 46-60 degrees C (with half inactivation at 54 degrees C) and that of the photochemical reaction center from 44-55 degrees C (with half inactivation at 51 degrees C) to 52-63 degrees C (with half inactivation at 58 degrees C).
  • However, in light, PSII was more sensitive to heat stress; when moderate heat stress, such as 40 degrees C, was combined with light stress, PSII was rapidly inactivated, although these stresses, when applied separately, did not inactivate either the oxygen-evolving complex or the photochemical reaction center.
  • Further our studies demonstrated that the moderate heat stress inhibited the repair of PSII during photoinhibition at the site of synthesis de novo of the D1 protein but did not accelerate the photodamage directly.
  • [MeSH-major] Betaine / pharmacology. Heat Stress Disorders / enzymology. Light. Photosystem II Protein Complex / antagonists & inhibitors. Photosystem II Protein Complex / biosynthesis

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  • (PMID = 17991419.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Photosystem II Protein Complex; 3SCV180C9W / Betaine
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58. Lipcan MT 3rd, Loren DE, Palazzo JP, Bibbo M, Dimarino AJ, Cohen S: Endosonographic diagnosis of recurrent gastrointestinal stromal tumors associated with Carney's syndrome. Gastroenterology; 2005 Jan;128(1):169-74
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  • [Title] Endosonographic diagnosis of recurrent gastrointestinal stromal tumors associated with Carney's syndrome.
  • This is a report of a patient who manifests all of the features of Carney's syndrome, including gastrointestinal stromal tumors (GISTs), extra-adrenal paragangliomas, and pulmonary chondromas.
  • The patient underwent surgical resection of a gastric GIST; a retroperitoneal, nonfunctional paraganglioma; and a mediastinal, catecholamine-secreting paraganglioma (pheochromocytoma).
  • Recurrence of stromal tumors following complete resection is common in Carney's syndrome and presents considerable management challenges.
  • (1) Carney's syndrome, although rare, should be considered in patients with foregut GISTs;.
  • (2) GISTs associated with Carney's syndrome, like sporadic gastric GISTs, may have a more indolent clinical course; and (3) EUS-FNA may be useful for the diagnosis and management of GISTs in this syndrome.
  • [MeSH-major] Endosonography. Gastrointestinal Stromal Tumors / diagnosis. Neoplasms, Multiple Primary / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Chondroma / diagnosis. Female. Humans. Lung Neoplasms / diagnosis. Mediastinal Neoplasms / diagnosis. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Paraganglioma, Extra-Adrenal / diagnosis. Retroperitoneal Neoplasms / diagnosis


59. Kohler AC, Gae DD, Richley MA, Stoll S, Gunn A, Lim S, Martin SS, Doukov TI, Britt RD, Ames JB, Lagarias JC, Fisher AJ: Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants. Biochemistry; 2010 Jul 27;49(29):6206-18
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  • PCC 6803 PcyA in the initial oxidized and one-electron reduced radical states.
  • Unlike wild-type PcyA, both mutants possess a bilin-interacting axial water molecule that is ejected from the active site upon formation of the enzyme-bound neutral radical complex.

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  • (PMID = 20557110.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] ENG
  • [Databank-accession-numbers] PDB/ 3F0L/ 3F0M/ 3NB8/ 3NB9
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM073789; United States / NIGMS NIH HHS / GM / T32 GM007377-31A1; United States / NIGMS NIH HHS / GM / T32-GM007377; United States / NIGMS NIH HHS / GM / R01 GM073789-04; United States / NEI NIH HHS / EY / EY012347; United States / NIGMS NIH HHS / GM / T32 GM007377; United States / NIGMS NIH HHS / GM / GM73789; United States / NIGMS NIH HHS / GM / GM007377-31A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Bile Pigments; 0 / Phycobilins; 059QF0KO0R / Water; 11016-15-2 / Phycocyanin; 20298-86-6 / phycocyanobilin; 4QD397987E / Histidine; 7006-34-0 / Asparagine; EC 1.- / Oxidoreductases; EC 1.- / phycocyanobilin ferredoxin oxidoreductase, Synechocystis
  • [Other-IDs] NLM/ NIHMS219109; NLM/ PMC2914091
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60. Yang J, Dedovic K, Zhang Q: Self-esteem and risky decision-making: an ERP study. Neurocase; 2010 Dec;16(6):512-9
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  • Dipole source analysis indicated that this positive component was generated in posterior cingulate cortex (PCC).

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  • (PMID = 20503131.001).
  • [ISSN] 1465-3656
  • [Journal-full-title] Neurocase
  • [ISO-abbreviation] Neurocase
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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61. Hagemann M, Ribbeck-Busch K, Klähn S, Hasse D, Steinbruch R, Berg G: The plant-associated bacterium Stenotrophomonas rhizophila expresses a new enzyme for the synthesis of the compatible solute glucosylglycerol. J Bacteriol; 2008 Sep;190(17):5898-906
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  • This enzyme from S. rhizophila represented a novel fusion protein composed of a putative C-terminal GG-phosphate synthase domain and an N-terminal putative GG-phosphate phosphatase domain, which was named GgpPS.
  • Enzyme activity tests revealed the expected abilities of the full-length protein to synthesize GG and the truncated GgpPS to synthesize GG-phosphate.
  • However, dephosphorylation of GG-phosphate was detected only with the complete GgpPS protein.
  • These enzyme activities were confirmed by complementation experiments using defined GG-defective mutants of the cyanobacterium Synechocystis sp. strain PCC 6803.

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  • (PMID = 18586931.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Glucosides; 0 / Salts; 0 / glucosylglycerol; EC 2.4.1.- / Glucosyltransferases; EC 2.4.1.- / glucosylglycerol-phosphate synthase; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.- / glucosylglycerol-phosphate phosphatase
  • [Other-IDs] NLM/ PMC2519522
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62. Promnares K, Komenda J, Bumba L, Nebesarova J, Vacha F, Tichy M: Cyanobacterial small chlorophyll-binding protein ScpD (HliB) is located on the periphery of photosystem II in the vicinity of PsbH and CP47 subunits. J Biol Chem; 2006 Oct 27;281(43):32705-13
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  • PCC 6803, we constructed several mutants in which ScpD was expressed as a His-tagged protein (ScpDHis).
  • Single particle image analysis identified the location of the labeled ScpDHis at the periphery of the PSII core complex in the vicinity of the PsbH and CP47.
  • [MeSH-major] Bacterial Proteins / analysis. Cyanobacteria / chemistry. Light-Harvesting Protein Complexes / metabolism. Photosystem II Protein Complex / metabolism

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  • (PMID = 16923804.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Epitopes; 0 / Light-Harvesting Protein Complexes; 0 / Photosystem II Protein Complex; 0 / Protein Subunits; 4QD397987E / Histidine; 7OV03QG267 / Nickel; KA90006V9D / Nitrilotriacetic Acid
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63. Pickering TG, Clemow L: Paroxysmal hypertension: the role of stress and psychological factors. J Clin Hypertens (Greenwich); 2008 Jul;10(7):575-81
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  • A case report describes the clinical picture frequently seen in specialty hypertension practice, a patient with paroxysmal or intermittent hypertension who proves not to have a pheochromocytoma.
  • The variety of diagnostic labels given to these patients is reviewed, including pseudopheochromocytoma, panic attacks, and hyperventilation syndrome.
  • The clinical features, pathology, diagnosis, and treatment of these syndromes are outlined.
  • It is proposed that successful management of these patients may be best achieved by collaborative care between a hypertension specialist and a psychiatrist or clinical psychologist with expertise in cognitive-behavioral panic management, stress-reduction techniques including controlled breathing, and treating health anxiety.
  • The use of drugs effective for treatment of panic disorder can also be helpful in managing these patients.
  • [MeSH-minor] Aged, 80 and over. Female. Humans. Hyperventilation / complications. Panic Disorder / complications. Pheochromocytoma / complications. Risk Factors

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  • (PMID = 18607143.001).
  • [ISSN] 1524-6175
  • [Journal-full-title] Journal of clinical hypertension (Greenwich, Conn.)
  • [ISO-abbreviation] J Clin Hypertens (Greenwich)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 49
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64. Tarant NS, Dacanay RG, Mecklenburg BW, Birmingham SD, Lujan E, Green R: Acute appendicitis in a patient with undiagnosed pheochromocytoma. Anesth Analg; 2006 Feb;102(2):642-3
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  • [Title] Acute appendicitis in a patient with undiagnosed pheochromocytoma.
  • Pheochromocytoma is a rare catecholamine-producing tumor that can cause severe hypertension and other systemic disturbances.
  • A clinical challenge arises when a patient with a previously undiagnosed and untreated pheochromocytoma presents with a surgical emergency.
  • We describe a patient presenting with acute appendicitis in whom surgery was cancelled because of suspected pheochromocytoma.
  • The possibility of mortality associated with surgery in a patient with an undiagnosed pheochromocytoma outweighed the risk of nonoperative management for appendicitis.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Appendicitis / complications. Pheochromocytoma / complications


65. Gimenez-Roqueplo AP, Lehnert H, Mannelli M, Neumann H, Opocher G, Maher ER, Plouin PF, European Network for the Study of Adrenal Tumours (ENS@T) Pheochromocytoma Working Group: Phaeochromocytoma, new genes and screening strategies. Clin Endocrinol (Oxf); 2006 Dec;65(6):699-705
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  • [Title] Phaeochromocytoma, new genes and screening strategies.
  • Following recent advances in the genetics of phaeochromocytomas and paragangliomas, the members of the European Network for the Study of Adrenal Tumours (ENS@T) Phaeochromocytoma Working Group have decided to share their genotyping data and to propose European recommendations for phaeochromocytoma/functional paraganglioma (PH/FPGL) genetic testing.
  • In 166 patients (25.9%) the disease was familial and caused by germline mutations in VHL (56), SDHB (34), SDHD (31), RET (31) or NF1 (14), causing von Hippel-Lindau disease, SDHB- or SDHD-PH/FPGL syndromes, multiple endocrine neoplasia type 2 (MEN 2) and type 1 neurofibromatosis (NF1), respectively.
  • In almost 60% of inherited cases it was possible to formulate a probable genetic diagnosis based on family history and/or typical syndromic presentation.
  • Several clinical characteristics, such as young age at onset, the presence of bilateral, extra-adrenal or multiple tumours or a malignant tumour, should be seen as indications for genetic testing.
  • The ENS@T Phaeochromocytoma Working Group recommends the genetic testing of all patients with PH and FPGL and suggests a practice algorithm for the management of their exploration.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Genes, Neoplasm. Pheochromocytoma / genetics
  • [MeSH-minor] Algorithms. Genetic Markers. Genetic Testing. Genotype. Germ-Line Mutation. Humans. Paraganglioma / diagnosis. Paraganglioma / genetics. Patient Selection

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  • (PMID = 17121518.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
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66. González Quijada S, Astorga Romón M: [Metabolic profile and end-organ damage in essential hypertensive patients according to the control of blood pressure in primary care centres]. An Med Interna; 2005 Apr;22(4):172-6
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  • [Title] [Metabolic profile and end-organ damage in essential hypertensive patients according to the control of blood pressure in primary care centres].
  • [Transliterated title] Perfil metabólico y deterioro de órganos diana en hipertensos esenciales según el control de la presión arterial en la consulta.
  • BACKGROUND AND OBJECTIVE: To evaluate the degree of metabolic control and end-organ damage in a group of hypertensive patients with poor and good blood pressure (BP) control in primary health care centers.
  • PATIENTS AND METHODS: Observational study with diagnostic intervention, performed in 16 primary care centers of Burgos (Spain).
  • The following parameters were determined: clinic history, casual BP, 24-h ambulatory blood pressure monitoring (ABPM), electrocardiography, and clinic analysis in plasma and 24-hour urine.
  • No significant differences were detected between the two groups for the levels of c-HDL > 130 mg/dl (62% vs. 62%), microalbuminuria (5% vs. 10%) and basal glucose levels > 126 mg/dl (105 vs. 15%).
  • The access to ABPM by primary health care centers could modify the therapeutic management in a significant subgroup of hypertensive patients with poor BP control.

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  • (PMID = 16004513.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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67. Schiavi F, Boedeker CC, Bausch B, Peçzkowska M, Gomez CF, Strassburg T, Pawlu C, Buchta M, Salzmann M, Hoffmann MM, Berlis A, Brink I, Cybulla M, Muresan M, Walter MA, Forrer F, Välimäki M, Kawecki A, Szutkowski Z, Schipper J, Walz MK, Pigny P, Bauters C, Willet-Brozick JE, Baysal BE, Januszewicz A, Eng C, Opocher G, Neumann HP, European-American Paraganglioma Study Group: Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene. JAMA; 2005 Oct 26;294(16):2057-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene.
  • CONTEXT: Paraganglioma syndrome includes inherited head and neck paragangliomas (HNPs) and adrenal or extra-adrenal pheochromocytomas and are classified according to the susceptibility genes SDHB, SDHC, and SDHD.
  • DESIGN, SETTING, AND PATIENTS: Genetic screening for SDHC mutations in an international HNP registry of 121 unrelated index cases and in 371 sporadic cases from a pheochromocytoma registry, conducted January 1, 2001, until December 31, 2004.
  • RESULTS: The prevalence of SDHC carriers was 4% in HNP but 0% in pheochromocytoma index cases.
  • None of the SDHC mutation carriers had signs of pheochromocytoma.
  • Location, number of tumors, malignancy, and age were different: more carotid body tumors were found in SDHC (13/22 [59%]) than in sporadic HNPs (29/90 [32%], P = .03), as well as fewer instances of multiple tumors in SDHC (2/22) than in SDHD (24/42; P<.001), 0 malignant tumors in SDHC vs 6/15 in SDHB (P = .002), and younger age at diagnosis in SDHC than in sporadic HNPs (45 vs 52 years; P = .03).
  • CONCLUSIONS: Patients with HNP, but not those with pheochromocytoma, harbor SDHC mutations in addition to those in SDHB and SDHD.

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  • [CommentIn] JAMA. 2006 Feb 8;295(6):625; author reply 625 [16467230.001]
  • [ErratumIn] JAMA. 2006 Feb 8;295(6):628
  • (PMID = 16249420.001).
  • [ISSN] 1538-3598
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01HD39058-04; United States / NICHD NIH HHS / HD / R01HD39058-04S1
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iron-Sulfur Proteins; 0 / Membrane Proteins; 0 / Protein Subunits; 0 / SDHC protein, human; 0 / SDHD protein, human; EC 1.3.5.1 / SDHB protein, human; EC 1.3.99.1 / Succinate Dehydrogenase
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68. Ji BS, Gao Y: Protective effect of trihexyphenidyl on hydrogen peroxide-induced oxidative damage in PC12 cells. Neurosci Lett; 2008 May 23;437(1):50-4
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  • The protective effect of trihexyphenidyl (THY) on hydrogen peroxide-induced oxidative damage was investigated in the rat pheochromocytoma line PC12 cells.
  • However, preincubation of cells with THY prior to H(2)O(2) exposure attenuated all the changes mentioned above, THY exhibited protective effect against H(2)O(2)-induced toxicity in PC12 cells, indicating that the compound may be a potential therapeutic agent for the diseases influenced by oxidative damage.

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  • (PMID = 18434016.001).
  • [ISSN] 1872-7972
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Antiparkinson Agents; 0 / Fluorescent Dyes; 0 / Reactive Oxygen Species; 0 / Tetrazolium Salts; 0 / Thiazoles; 1406-18-4 / Vitamin E; 298-93-1 / thiazolyl blue; 4Y8F71G49Q / Malondialdehyde; 6RC5V8B7PO / Trihexyphenidyl; BBX060AN9V / Hydrogen Peroxide; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 1.15.1.1 / Superoxide Dismutase
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69. Kuji I, Imabayashi E, Minagawa A, Matsuda H, Miyauchi T: Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma. Ann Nucl Med; 2008 Apr;22(3):231-5
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  • [Title] Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma.
  • We present an interesting case with a central mediastinal pheochromocytoma showing intense F-18 fluorodeoxyglucose (FDG) uptake in tumor and systemic brown adipose tissue (BAT) mimicking metastases.
  • The findings of hypertension and high plasma catecholamine concentration suggested the presence of pheochromocytoma.
  • Mediastinal tumor showed intense FDG uptake and faint uptake of I-131 metaiodobenzylguanidine.
  • The mediastinal tumor was resected along with an adhesion to the left atrial wall and pathologically confirmed as pheochromocytoma.
  • The plasma catecholamine concentration and blood pressure then reverted to normal.
  • The FDG uptake in BAT disappeared after tumor resection.
  • [MeSH-major] Abdominal Neoplasms / secondary. Adipose Tissue, Brown / radionuclide imaging. Adrenal Gland Neoplasms / pathology. Bone Neoplasms / secondary. Head and Neck Neoplasms / secondary. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / radionuclide imaging. Pheochromocytoma / radionuclide imaging
  • [MeSH-minor] 3-Iodobenzylguanidine / pharmacokinetics. Adult. Catecholamines / blood. Diagnosis, Differential. Female. Fluorodeoxyglucose F18 / pharmacokinetics. Humans. Hypertension. Lymphatic Metastasis / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals / pharmacokinetics. Tomography, X-Ray Computed


70. Wei X, Mingjia H, Xiufeng L, Yang G, Qingyu W: Identification and biochemical properties of Dps (starvation-induced DNA binding protein) from cyanobacterium Anabaena sp. PCC 7120. IUBMB Life; 2007 Oct;59(10):675-81
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  • [Title] Identification and biochemical properties of Dps (starvation-induced DNA binding protein) from cyanobacterium Anabaena sp. PCC 7120.
  • PCC 7120 shared high similarity with Dps family proteins.
  • PCC 7120 cells.
  • This is the first description of Dps from heterocystous cyanobacterium Anabaena sp. PCC 7120.

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  • (PMID = 17852566.001).
  • [ISSN] 1521-6543
  • [Journal-full-title] IUBMB life
  • [ISO-abbreviation] IUBMB Life
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ NC003272
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA-Binding Proteins; 0 / DPS protein, Bacteria; 0 / Iron-Binding Proteins; E1UOL152H7 / Iron; EC 1.16.3.1 / Ceruloplasmin
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71. Nishina A, Sekiguchi A, He Y, Koketsu M, Furukawa S: Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase. J Neurosci Res; 2008 Feb 15;86(3):720-5
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  • [Title] Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
  • We found that ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] caused phosphorylation of mitogen-activated protein kinase (MAPK), followed by expression of neurofilament-M, a neuron-specific protein, in cultured PC12 rat pheochromocytoma cells.
  • [MeSH-major] Antioxidants / pharmacology. Azoles / pharmacology. Mitogen-Activated Protein Kinases / metabolism. Neurofilament Proteins / biosynthesis. Organoselenium Compounds / pharmacology. PC12 Cells / metabolism. Selenium

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17918745.001).
  • [ISSN] 1097-4547
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Azoles; 0 / Butadienes; 0 / Carbazoles; 0 / Indole Alkaloids; 0 / Neurofilament Proteins; 0 / Nitriles; 0 / Organoselenium Compounds; 0 / Quinazolines; 0 / Tyrphostins; 0 / U 0126; 111365-29-8 / neurofilament protein M; 170449-18-0 / tyrphostin AG 1478; 40X2P7DPGH / ebselen; 97161-97-2 / staurosporine aglycone; EC 2.4.2.31 / Pertussis Toxin; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; H6241UJ22B / Selenium
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72. Hirose M, Tomoda F, Iwamoto J, Kinuno H, Yamazaki H, Nakagawa T, Koike T, Kagitani S, Inoue H, Fuse H: [Case of bladder pheochromocytoma with familial clustering]. Nihon Jinzo Gakkai Shi; 2010;52(5):578-83
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  • [Title] [Case of bladder pheochromocytoma with familial clustering].
  • We report herein a rare female case of bladder pheochromocytoma with familial clustering.
  • Her mother had received an operation for bladder pheochromocytoma.
  • Plasma noradrenalin level (14,399 pg/mL)was remarkably elevated, although the plasma adrenalin level (52 pg/mL) was within the normal limits.
  • Venous blood sampling disclosed that the plasma noradrenalin concentration was highest at the lower level of the inferior vena cava.
  • Therefore, a diagnosis of bladder pheochromocytoma with familial clustering was made and the pheochromocytoma was surgically removed.
  • [MeSH-major] Pheochromocytoma / diagnosis. Pheochromocytoma / genetics. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / genetics

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  • (PMID = 20715590.001).
  • [ISSN] 0385-2385
  • [Journal-full-title] Nihon Jinzo Gakkai shi
  • [ISO-abbreviation] Nihon Jinzo Gakkai Shi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; X4W3ENH1CV / Norepinephrine
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73. Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr: The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev; 2008 Apr 1;22(7):884-93
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  • [Title] The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
  • Germline mutations of these genes cause familial pheochromocytoma and other neural crest-derived tumors.
  • We identified inherited loss-of-function KIF1Bbeta missense mutations in neuroblastomas and pheochromocytomas and an acquired loss-of-function mutation in a medulloblastoma, arguing that KIF1Bbeta is a pathogenic target of these deletions.
  • [MeSH-major] Apoptosis. Chromosomes, Mammalian / genetics. DNA-Binding Proteins / metabolism. Immediate-Early Proteins / metabolism. Kinesin / metabolism. Nerve Tissue Proteins / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Animals. Animals, Newborn. Cells, Cultured. Child. Chromosome Mapping. HeLa Cells. Humans. Hypoxia-Inducible Factor-Proline Dioxygenases. Immunoblotting. Medulloblastoma / genetics. Medulloblastoma / pathology. Mice. Mice, Knockout. Models, Biological. Mutation, Missense. Neuroblastoma / genetics. Neuroblastoma / pathology. Neurons / cytology. Neurons / metabolism. PC12 Cells. Pheochromocytoma / genetics. Pheochromocytoma / pathology. Procollagen-Proline Dioxygenase. RNA Interference. Rats

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  • (PMID = 18334619.001).
  • [ISSN] 0890-9369
  • [Journal-full-title] Genes & development
  • [ISO-abbreviation] Genes Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Immediate-Early Proteins; 0 / Kif1b protein, mouse; 0 / Nerve Tissue Proteins; 0 / Tumor Suppressor Proteins; EC 1.14.11.2 / Procollagen-Proline Dioxygenase; EC 1.14.11.29 / Egln1 protein, mouse; EC 1.14.11.29 / Hypoxia-Inducible Factor-Proline Dioxygenases; EC 3.6.1.- / Kinesin
  • [Other-IDs] NLM/ PMC2279200
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74. Abourazzak S, Atmani S, Arqam LE, Chaouki S, Labib S, Harrandou M, Tizniti S, Bouabdellah Y, Bouharrou A, Hida M: Cerebral ischaemic stroke and bilateral pheochromocytoma. BMJ Case Rep; 2010;2010
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  • [Title] Cerebral ischaemic stroke and bilateral pheochromocytoma.
  • We report a case of a 10-year-old girl who presented with an acute neurological deficit preceded by a 2 month history of headaches.
  • A computed tomography (CT) scan of her brain scan showed a cerebral ischaemic stroke, and paroxysmal arterial hypertension led us to suspect pheochromocytoma.
  • The diagnosis was confirmed by elevated urinary catecholamine and by imaging (abdominal x-ray and abdominal/pelvic CT scan).
  • Bilateral adrenal gland tumours were successfully removed.
  • This report illustrates an uncommon presentation of pheochromocytoma in children and shows the importance of a careful investigation for pheochromocytoma as a cause of hypertension in children with cerebral ischaemic stroke.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Pheochromocytoma / radiography. Stroke / radiography
  • [MeSH-minor] Child. Diagnosis, Differential. Echocardiography. Electrocardiography. Female. Humans. Radiography, Abdominal. Tomography, X-Ray Computed


75. Chianese J, Hoberman A, Paradise JL, Colborn DK, Kearney D, Rockette HE, Kurs-Lasky M: Spectral gradient acoustic reflectometry compared with tympanometry in diagnosing middle ear effusion in children aged 6 to 24 months. Arch Pediatr Adolesc Med; 2007 Sep;161(9):884-8
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  • SETTING: Inner-city primary care center in Pittsburgh, Pennsylvania.
  • [MeSH-major] Acoustic Impedance Tests / methods. Acoustics. Otitis Media with Effusion / diagnosis

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  • (PMID = 17768289.001).
  • [ISSN] 1072-4710
  • [Journal-full-title] Archives of pediatrics & adolescent medicine
  • [ISO-abbreviation] Arch Pediatr Adolesc Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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76. Frazee SG, Kirkpatrick P, Fabius R, Chimera J: Leveraging the trusted clinician: documenting disease management program enrollment. Dis Manag; 2007 Feb;10(1):16-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leveraging the trusted clinician: documenting disease management program enrollment.
  • The objective of this study was to test the hypothesis that an integrated disease management (IDM) protocol (patent-pending), which combines telephonic-delivered disease management (TDM) with a worksite-based primary care center and pharmacy delivery, would yield higher contact and enrollment rates than traditional remote disease management alone.
  • IDM is characterized by the combination of standard TDM with a worksite-based primary care and pharmacy delivery protocol led by trusted clinicians.
  • Integrating a worksite-based primary care and pharmacy delivery system led by trusted clinicians with traditional TDM increases contact and enrollment rates, resulting in higher patient engagement.
  • The IDM protocol should be adopted by employers seeking higher returns on their investment in disease management programming.
  • [MeSH-major] Clinical Protocols. Disease Management. Occupational Health Services / organization & administration. Pharmaceutical Services / organization & administration. Primary Health Care / organization & administration

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  • (PMID = 17309361.001).
  • [ISSN] 1093-507X
  • [Journal-full-title] Disease management : DM
  • [ISO-abbreviation] Dis Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Wakil A, Atkin S: Secondary amenorrhoea due to pheochromocytoma: a case report. Cases J; 2008;1(1):30
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  • [Title] Secondary amenorrhoea due to pheochromocytoma: a case report.
  • INTRODUCTION: Pheochromocytoma is a chromaffin cell catecholamine-secreting tumour originating from the adrenal medulla.
  • CASE PRESENTATION: We report here an unusual presentation of pheochromocytoma with secondary amenorrhoea and its resolution after medical treatment with the alpha adrenergic blocker, Phenoxybenzamine.
  • CONCLUSION: Pheochromocytoma is a rare cause of secondary amenorrhoea.

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  • [ISSN] 1757-1626
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  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2481240
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78. Cebrián-Cuenca AM, Díez-Domingo J, Rodríguez MS, Puig-Barberá J, Navarro-Pérez J, 'Herpes Zoster Research Group of the Valencian Community': Epidemiology of herpes zoster infection among patients treated in primary care centres in the Valencian community (Spain). BMC Fam Pract; 2010;11:33
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  • [Title] Epidemiology of herpes zoster infection among patients treated in primary care centres in the Valencian community (Spain).
  • METHODS: From December 1st 2006 to December 1st 2007, a prospective study was carried out in 24 primary health care centres that together provide care for a population of 36,030 persons aged >14 years.
  • We included all adult patients with a clinical diagnosis of HZ who were seen at these centres during the one-year study period.
  • The median time from symptoms onset to diagnosis was 6.3 days (range: 2.0-8.3).
  • CONCLUSIONS: HZ is a common illness in our region (especially in the older population) that causes a significant clinical burden on primary care providers.
  • [MeSH-minor] Adolescent. Adult. Aged. Antiviral Agents / therapeutic use. Female. Humans. Incidence. Male. Middle Aged. Population. Primary Health Care. Spain / epidemiology. Young Adult

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  • (PMID = 20459608.001).
  • [ISSN] 1471-2296
  • [Journal-full-title] BMC family practice
  • [ISO-abbreviation] BMC Fam Pract
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents
  • [Other-IDs] NLM/ PMC2874789
  • [Investigator] Momparler-Martínez C; Navarrete-Villalta JM; García-García C; Guillem-Miralles JF; Pereiró-Berenguer I; Ruiz-Varea N; Vives-Rebollar L; Feliú-Morte C; Alvarez-Martínez M; Cañada-Blasco J; Picón-García E; Pla-García JA; Robles-Pastor E; Fillols FC; Cervera-Pérez I; Colomer-Paché M; López-De los Mozos AR; Mir-Mora JE; Latorre-Atienza MA; Matoses-Nácher D; Pascual-López L; Gorgues-Comás R; i Espert FJ
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79. Moret ME, Keller SF, Slootweg JC, Chen P: Mononuclear platinum(II) complexes incorporating kappa2-carboxylate ligands: synthesis, structure, and reactivity. Inorg Chem; 2009 Jul 20;48(14):6972-8
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  • The chloro-bridged dimer [(PC)Pt(mu-Cl)](2) (PC = [((t)Bu(2)P-o-C(6)H(4))-CMe(2)](-)) reacts with silver(I) acetate to yield the monomeric kappa(2)-acetate complex [(PC)Pt(kappa(2)-OOCMe)].
  • [(PC)Pt(OOCCF(3))] undergoes a ligand-dehydrogenation reaction in hot trifluoroacetic acid to yield [(PCC)Pt(OOCCF(3))(2)] (PCC = ((t)Bu(2)P-o-C(6)H(4))-C(Me)=CH(2)).

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  • (PMID = 19548692.001).
  • [ISSN] 1520-510X
  • [Journal-full-title] Inorganic chemistry
  • [ISO-abbreviation] Inorg Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Gómez-Restrepo C, Bohórquez Peñaranda A, Okuda Benavides M, Gil Laverde JF, Sanchez Díaz N: Primary care physician satisfaction with patients diagnosed with depression: International Depression Project results from Colombia. Rev Bras Psiquiatr; 2006 Dec;28(4):283-9
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  • [Title] Primary care physician satisfaction with patients diagnosed with depression: International Depression Project results from Colombia.
  • OBJECTIVE: To characterize physician satisfaction with doctor-patient encounters, distinguishing between those involving patients diagnosed with depression and those involving patients without depression, as well as to determine the impact of an educational intervention aimed at improving the recognition and management of depression in primary care practice, in Bogotá, Columbia.
  • METHOD: Physician satisfaction when treating outpatients in primary care centers was assesed by means of a questionnaire applied before and after the intervention.
  • [MeSH-major] Depression / therapy. Job Satisfaction. Physician-Patient Relations. Physicians, Family / psychology. Primary Health Care / standards
  • [MeSH-minor] Adult. Education, Medical, Continuing. Female. Humans. Male. Nurse-Patient Relations. Nurses / psychology. Outcome Assessment (Health Care). Outpatients. Self Concept. Surveys and Questionnaires


81. Park SY, Kim YW, Kim JE, Kim JY: Age-associated changes in fat metabolism in the rat and its relation to sympathetic activity. Life Sci; 2006 Nov 2;79(23):2228-33
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  • In this study, to determine if age associated changes in fat metabolism in skeletal muscle and liver were related with sympathetic activity, we measured sympathetic activity and palmitate oxidation rate, carnitine palmitoyltransferase-1 (CPT-1) activity, and triglyceride concentration in skeletal muscle and liver of rats at 8, 30 and 60 weeks of age.
  • Body weight, intra-abdominal percent of fat mass, and plasma level of insulin, leptin, and triglyceride were all significantly increased with age.
  • Tissue triglyceride concentration was increased with age in liver and skeletal muscle.
  • The palmitate oxidation rate in liver and skeletal muscle was reduced with age in rats and inversely correlated with tissue triglyceride concentration.
  • Plasma catecholamine concentration and sympathetic activity, as measured by spectral analysis of heart rate variability, were increased with age.
  • Plasma norepinephrine or epinephrine and tissue triglyceride had a positive correlation in liver and skeletal muscle.
  • Plasma norepinephrine or epinephrine to tissue triglyceride ratio was similar according to age.
  • In summary, in spite of increased sympathetic activity with age, the tissue triglyceride concentration was increased.

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  • (PMID = 16890963.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Fats; 0 / Insulin; 0 / Leptin; 0 / Palmitates; 0 / Triglycerides; EC 2.3.1.21 / Carnitine O-Palmitoyltransferase
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82. Jódar-Solà G, Cadena-Andreu A, Parellada-Esquius N, Martínez-Roldán J: [Continuity of care: role of the link nurse]. Aten Primaria; 2005 Dec;36(10):558-62
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  • [Title] [Continuity of care: role of the link nurse].
  • [Transliterated title] Continuidad asistencial: rol de la enfermera de enlace.
  • SETTING: Primary vare in the towns of Sant Boi de Llobregat and Sant Vicenç dels Horts (Barcelona) and the County Hospital of Sant Boi, Spain.
  • PATIENTS: Patients discharged from the hospital (October 2000-October 2002) and who needed ongoing care in the primary care centre or at home.
  • INTERVENTIONS: Joint visits of the link nurse and the hospital unit's supervisor to work out the care plan before discharge.
  • The PC team was informed of the transfer of the patient and his/her care plan.
  • Subsequent home visits were by the link nurse, the primary care team or both together.
  • The most common nursing diagnosis made was physical mobility disorder (61% of patients).

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  • (PMID = 16507290.001).
  • [ISSN] 0212-6567
  • [Journal-full-title] Atencion primaria
  • [ISO-abbreviation] Aten Primaria
  • [Language] SPA
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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83. Conlon NP, Redmond KC, Celi LA: Spontaneous hemothorax in a patient with neurofibromatosis type 1 and undiagnosed pheochromocytoma. Ann Thorac Surg; 2007 Sep;84(3):1021-3
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  • [Title] Spontaneous hemothorax in a patient with neurofibromatosis type 1 and undiagnosed pheochromocytoma.
  • A subsequently diagnosed underlying pheochromocytoma may be implicated in rupture of the arterial wall.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Aneurysm, Ruptured / complications. Hemothorax / etiology. Mammary Arteries. Neurofibromatosis 1 / complications. Pheochromocytoma / complications


84. Matsubayashi H, Uesaka K, Kanemoto H, Sugiura T, Mizuno T, Sasaki K, Ono H, Hruban R: Multiple endocrine neoplasms and serous cysts of the pancreas in a patient with von Hippel-Lindau disease. J Gastrointest Cancer; 2010 Sep;41(3):197-202
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  • [Title] Multiple endocrine neoplasms and serous cysts of the pancreas in a patient with von Hippel-Lindau disease.
  • INTRODUCTION: Patients with the von Hippel-Lindau (VHL) syndrome have an increased risk of developing pancreatic endocrine neoplasms.
  • CASE REPORT: A 40-year-old female with a past history of bilateral adrenal pheochromocytomas, whose brother had a history of a malignant pheochromocytoma, was referred to our institution with symptoms of adrenal crisis including general fatigue and insomnia in spite of increasing predonisolone therapy.
  • The patient remains free of disease 5 years after surgery.
  • [MeSH-major] Multiple Endocrine Neoplasia / pathology. Pancreatic Cyst / pathology. Pancreatic Neoplasms / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adrenal Gland Neoplasms / surgery. Adrenalectomy. Adult. Female. Humans. Pheochromocytoma / surgery


85. Kovacs FM, Muriel A, Medina JM, Abraira V, Sánchez MD, Jaúregui JO, Spanish Back Pain Research Network: Psychometric characteristics of the Spanish version of the FAB questionnaire. Spine (Phila Pa 1976); 2006 Jan 1;31(1):104-10
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  • STUDY DESIGN: Validation of a translated, culturally adapted questionnaire.
  • The study was done in 12 primary care centers and 9 hospital outpatient clinics from seven regions in Spain, with 209 acute, subacute, and chronic patients who visited their physician for LBP: 53 in the pilot phase and 156 in the validation phase.

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  • (PMID = 16395186.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
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86. Pekmezaris R, Cooper L, Efferen L, Mastrangelo A, Silver A, Eichorn A, Walia R, Mir T, Liberman T, Weiner J, Steinberg H: Transforming the mortality review conference to assess palliative care in the acute care setting: a feasibility study. Palliat Support Care; 2010 Dec;8(4):421-6
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  • [Title] Transforming the mortality review conference to assess palliative care in the acute care setting: a feasibility study.
  • OBJECTIVE: This project sought to evaluate the impact of a hospital-based Palliative Care Consultation (PCC) service utilizing a common practice: the resident mortality review conference.
  • METHOD: Internal Medicine residents used a revised chart audit tool during the mortality review conference, which included domains described in the Clinical Practice Guidelines for Quality Palliative Care (2004).
  • This study attempted to transform the common practice into a methodology for collecting data that could be used as a platform to assess the quality of hospital care near the end of life.
  • In this review, the residents were asked not only "what care was delivered appropriately?
  • RESULTS: The results showed that the mortality review process could be used to assess care at the end of life.
  • It also showed that those patients who received a PCC received better care.
  • Symptoms were addressed at a significantly higher rate for those patients who received a PCC than for those who did not.
  • SIGNIFICANCE OF RESULTS: The mortality review process was found to be valuable in assessing care delivery for patients near the end of life.
  • The tool yielded results that were consistent with findings of other studies looking at pain and symptom management, advance care planning, and the rate of palliative care consults across major diagnostic categories, supporting the face validity of the mortality review process.
  • [MeSH-major] Critical Care / methods. Mortality. Palliative Care / methods. Quality Assurance, Health Care. Referral and Consultation / organization & administration. Terminal Care / methods

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  • (PMID = 20875205.001).
  • [ISSN] 1478-9523
  • [Journal-full-title] Palliative & supportive care
  • [ISO-abbreviation] Palliat Support Care
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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87. Wong YT, Gruber J, Jenner AM, Ng MP, Ruan R, Tay FE: Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: protection by chronic oral intake of resveratrol. Free Radic Biol Med; 2009 Mar 15;46(6):799-809
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  • Our study in F2 four-way cross-hybrid mice was the first to evaluate the effects of aging and long-term RSV treatment (14.09+/-3.4 mg/L in drinking water for 6 or 12 months) on biomarkers of oxidative damage to DNA, 8-hydroxy-2'-deoxyguanosine (8OHdG); lipid, 8-iso-prostaglandin(2 alpha) (8-iso-PGF(2 alpha)); and protein, protein carbonyl content (PCC).
  • Chronic RSV treatment elevated total RSV plasma levels and reduced the observed age-dependent accumulation of (1) 8OHdG in liver and heart, (2) 8-iso-PGF(2 alpha) in heart and urine, and (3) PCC in liver and kidney.
  • However, a 12-month RSV intake resulted in significant elevation of 8-iso-PGF(2 alpha) and PCC in kidney.

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  • (PMID = 19159678.001).
  • [ISSN] 1873-4596
  • [Journal-full-title] Free radical biology & medicine
  • [ISO-abbreviation] Free Radic. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 8-isoprostaglandin A2; 0 / Biomarkers; 0 / Prostaglandins A; 0 / Stilbenes; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; G9481N71RO / Deoxyguanosine; Q369O8926L / resveratrol
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88. Huang G, Fan Q, Lechno-Yossef S, Wojciuch E, Wolk CP, Kaneko T, Tabata S: Clustered genes required for the synthesis of heterocyst envelope polysaccharide in Anabaena sp. strain PCC 7120. J Bacteriol; 2005 Feb;187(3):1114-23
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  • [Title] Clustered genes required for the synthesis of heterocyst envelope polysaccharide in Anabaena sp. strain PCC 7120.
  • As demonstrated with alr2835 (hepA) and alr2834 (hepC) mutants, heterocysts of Anabaena sp. strain PCC 7120, a filamentous cyanobacterium, must have an envelope polysaccharide layer (the Hep+ phenotype) to fix dinitrogen in an oxygen-containing milieu (the Fox+ phenotype).

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  • (PMID = 15659688.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Polysaccharides, Bacterial
  • [Other-IDs] NLM/ PMC545720
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89. Masamune T, Matsukawa T: [Pheochromocytoma]. Masui; 2010 Jul;59(7):883-6
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  • [Title] [Pheochromocytoma].
  • 0.1-0.2% of all cases of hypertension are caused by pheochromocytomas, or catecholamine-producing tumors derived from chromaffin tissue.
  • The occurrence of combined symptoms of paroxysmal headache, sweating, and hypertension is probably a more sensitive and specific indicator than any one biochemical test for pheochromocytoma.
  • Alpha-adrenergic receptor blockade with prazosin or doxazosin has been administered to restore plasma volume by counteracting the vasoconstrictive effects of high levels of catecholamines.
  • 25-50% of hospital deaths in patients with pheochromocytoma occur during induction of anesthesia or during operative procedures for other causes.
  • Adrenergic receptor blocking drugs probably reduce the complications of hypertensive crisis, the wide BP fluctuations during manipulation of the tumor (especially until venous drainage is obliterated), and the myocardial dysfunction that occurs perioperatively.
  • A reduction in mortality associated with resection of pheochromocytoma (from 40% to 60% to the current 0% to 6%) occurred when alpha-adrenergic receptor blockade was introduced as preoperative preparatory therapy.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Pheochromocytoma / complications
  • [MeSH-minor] Anesthesia / methods. Humans. Preoperative Care. Prognosis


90. Oliva R, Angelos P, Kaplan E, Bakris G: Pheochromocytoma in pregnancy: a case series and review. Hypertension; 2010 Mar;55(3):600-6
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  • [Title] Pheochromocytoma in pregnancy: a case series and review.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Hypertension / therapy. Pheochromocytoma / therapy. Pre-Eclampsia / therapy. Pregnancy Complications, Neoplastic / therapy


91. Brown MJ, Mackenzie IS, Ashby MJ, Balan KK, Appleton DS: AT2 receptor stimulation may halt progression of pheochromocytoma. Ann N Y Acad Sci; 2006 Aug;1073:436-43
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  • [Title] AT2 receptor stimulation may halt progression of pheochromocytoma.
  • Two patients with pheochromocytoma are described in whom treatment with a high dose of an angiotensin receptor blocker was associated with cessation of tumor growth as assessed by serial CT scanning and plasma norepinephrine estimation.
  • If the association with drug treatment is causal, the mechanism may be through stimulation of the AT2 receptor consequent upon the elevation of plasma angiotensin II levels induced by AT1 receptor blockade.
  • Similar observations in further patients should lead to a placebo-controlled study in patients with malignant or familial pheochromocytoma, or other tumors found to express the AT2 receptor.
  • [MeSH-major] Adrenal Gland Neoplasms / drug therapy. Angiotensin II Type 1 Receptor Blockers / therapeutic use. Biphenyl Compounds / therapeutic use. Pheochromocytoma / drug therapy. Receptors, Angiotensin / agonists. Tetrazoles / therapeutic use
  • [MeSH-minor] Adult. Disease Progression. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17102112.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiotensin II Type 1 Receptor Blockers; 0 / Biphenyl Compounds; 0 / Receptors, Angiotensin; 0 / Tetrazoles; 138402-11-6 / irbesartan
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92. Tahrani AA, Macleod AF: A diagnostic dilemma in diagnosing and managing an incidental phaeochromocytoma. Exp Clin Endocrinol Diabetes; 2006 Apr;114(4):204-7
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  • [Title] A diagnostic dilemma in diagnosing and managing an incidental phaeochromocytoma.
  • Incidental adrenal tumours are a common radiological finding.
  • We report a patient who had a phaeochromocytoma presented as an incidental adrenal mass on abdominal CT during investigations for recurrent chest infections.
  • Repeated urinary catecholamines measurements, plasma catecholamines, 24-hour urinary catecholamines and 24-hour urinary metanephrines all were normal.
  • MIBG scan showed increased uptake in the adrenal mass.
  • Histological examination of the adrenal mass was consistent with phaeochromocytoma.
  • Removal of the adrenal mass resulted in normalisation of blood pressure and abolishing of the patient's symptoms.
  • This case highlights the difficulty in deciding on further management of patients presenting with an adrenal incidentaloma.
  • This case also highlights the difficulty in diagnosing phaeochromocytoma and represents a reminder that plasma and urine catecholamines measurements could be normal in patients with symptomatic phaeochromocytoma.
  • This case also highlights that MIBG scan could reveal a phaeochromocytoma despite absence of biochemical markers.
  • [MeSH-major] 3-Iodobenzylguanidine / administration & dosage. Adrenal Gland Neoplasms / radiography. Pheochromocytoma / radiography. Radiopharmaceuticals / administration & dosage
  • [MeSH-minor] Catecholamines / blood. Catecholamines / urine. Diagnosis, Differential. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16705554.001).
  • [ISSN] 0947-7349
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Radiopharmaceuticals; 35MRW7B4AD / 3-Iodobenzylguanidine
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93. Pitroda S, Angstadt M, McCloskey MS, Coccaro EF, Phan KL: Emotional experience modulates brain activity during fixation periods between tasks. Neurosci Lett; 2008 Oct 3;443(2):72-6
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  • We examined brain activity during periods of FIXATION (viewing and rating gray-scale images) interspersed among periods of viewing and rating complex images ('PICTURE') with positive, negative, and neutral affective content.
  • We show that a selected group of brain regions (PCC, precuneus, IPL, vACC) do exhibit activity that is greater during FIXATION (>PICTURE); these regions have previously been implicated in the "default brain network".

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  • (PMID = 18674589.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / MH063262-04; United States / NIMH NIH HHS / MH / MH076198; United States / NIMH NIH HHS / MH / K23 MH076198-02; United States / NIMH NIH HHS / MH / MH069764; United States / NIMH NIH HHS / MH / R01 MH063262; United States / NIMH NIH HHS / MH / MH076198-02; United States / NIMH NIH HHS / MH / MH069764-01A1; United States / NIMH NIH HHS / MH / R03 MH069764-01A1; United States / NIMH NIH HHS / MH / MH063262; United States / NIMH NIH HHS / MH / R01 MH063262-04; United States / NIMH NIH HHS / MH / R03 MH069764; United States / NIMH NIH HHS / MH / K23 MH076198
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Other-IDs] NLM/ NIHMS70519; NLM/ PMC2558674
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94. Suzuki I, Kanesaki Y, Hayashi H, Hall JJ, Simon WJ, Slabas AR, Murata N: The histidine kinase Hik34 is involved in thermotolerance by regulating the expression of heat shock genes in synechocystis. Plant Physiol; 2005 Jul;138(3):1409-21
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  • PCC 6803 are involved in the transduction of signals associated with various kinds of environmental stress.
  • Mutation of the hik34 gene enhanced the levels of transcripts of a number of heat shock genes, including htpG and groESL1.

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  • (PMID = 15965020.001).
  • [ISSN] 0032-0889
  • [Journal-full-title] Plant physiology
  • [ISO-abbreviation] Plant Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA Primers; 0 / Heat-Shock Proteins; EC 2.7.- / Protein Kinases; EC 2.7.3.- / protein-histidine kinase
  • [Other-IDs] NLM/ PMC1176413
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95. Keren N, Liberton M, Pakrasi HB: Photochemical competence of assembled photosystem II core complex in cyanobacterial plasma membrane. J Biol Chem; 2005 Feb 25;280(8):6548-53
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  • [Title] Photochemical competence of assembled photosystem II core complex in cyanobacterial plasma membrane.
  • Cyanobacterial cells have two autonomous internal membrane systems, plasma membrane and thylakoid membrane.
  • In these oxygenic photosynthetic organisms the assembly of the large membrane protein complex photosystem II (PSII) is an intricate process that requires the recruitment of numerous protein subunits and cofactors involved in excitation and electron transfer processes.
  • Precise control of this assembly process is necessary because electron transfer reactions in partially assembled PSII can lead to oxidative damage and degradation of the protein complex.
  • PCC 6803 takes place sequentially.
  • In this organism partially assembled PSII complexes can be detected in the plasma membrane.
  • We conclude that PSII reaction center cores assembled in the plasma membrane are photochemically competent and can catalyze single turnovers.
  • Such a stepwise process protects cyanobacterial cells from potentially harmful consequences of performing water oxidation in a partially assembled PSII complex before it reaches its final destination in the thylakoid membrane.
  • [MeSH-major] Cell Membrane / chemistry. Cyanobacteria / ultrastructure. Photosystem II Protein Complex / biosynthesis

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  • (PMID = 15611096.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Multiprotein Complexes; 0 / Photosystem II Protein Complex
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96. Miwa S, Sugata T: [Asymptomatic pheochromocytoma of the urinary bladder : a case for which preoperative diagnosis was possible]. Hinyokika Kiyo; 2010 Feb;56(2):119-21
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  • [Title] [Asymptomatic pheochromocytoma of the urinary bladder : a case for which preoperative diagnosis was possible].
  • A 62-year-old man who was diagnosed as having a bladder tumor by computerized tomography in another hospital.
  • Cystoscopic examination revealed a submucosal tumor posterior to the right orifice.
  • Therefore, we considered the possibility of asymptomatic pheochromocytoma of the urinary bladder.
  • Pheochromocytoma of the bladder was diagnosed, and on October 25, 2006 a partial cystectomy and right ureteroneostomy were performed.
  • Histologically, the tumor was pheochromocytoma of the urinary bladder.
  • [MeSH-major] Pheochromocytoma / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 20186000.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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97. Kato H, Chibazakura T, Yoshikawa H: NblR is a novel one-component response regulator in the cyanobacterium Synechococcus elongatus PCC 7942. Biosci Biotechnol Biochem; 2008 Apr;72(4):1072-9
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  • [Title] NblR is a novel one-component response regulator in the cyanobacterium Synechococcus elongatus PCC 7942.
  • A response regulator, NblR, of the cyanobacterium Synechococcus elongatus PCC 7942 is known to induce expression of the nblA gene, a key factor in phycobilisome degradation (bleaching) under nutrient-deprivation conditions.

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  • (PMID = 18391440.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / MreC protein, Bacteria; 0 / NblR protein, Synechococcus sp.; 0 / Phycobilisomes; 0 / Transcription Factors; 30KYC7MIAI / Aspartic Acid; 63231-63-0 / RNA; N762921K75 / Nitrogen
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98. Tazi MF, Ahallal Y, Tazi E, Benlemlih A, Chbani L, Amarti A, El Fassi MJ, Farih MH: Pheochromocytoma of the urinary bladder: a case report. Cases J; 2009;2:8585
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  • [Title] Pheochromocytoma of the urinary bladder: a case report.
  • Urinary bladder pheochromocytoma is rare.
  • From a case report of unsuspected pheochromocytoma and literature review, the authors develop a diagnostic and therapeutic algorithm for the management of this ectopic pheochromocytoma localization.

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  • (PMID = 19830088.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740239
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99. Lyra C, Laamanen M, Lehtimäki JM, Surakka A, Sivonen K: Benthic cyanobacteria of the genus Nodularia are non-toxic, without gas vacuoles, able to glide and genetically more diverse than planktonic Nodularia. Int J Syst Evol Microbiol; 2005 Mar;55(Pt 2):555-68
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  • The planktonic strains of N. spumigena mostly had gas vacuoles and produced nodularin, whereas the benthic strains of N. sphaerocarpa and N. harveyana lacked gas vacuoles and did not produce nodularin (except for strain PCC 7804).

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  • (PMID = 15774625.001).
  • [ISSN] 1466-5026
  • [Journal-full-title] International journal of systematic and evolutionary microbiology
  • [ISO-abbreviation] Int. J. Syst. Evol. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AJ781131/ AJ781132/ AJ781133/ AJ781134/ AJ781135/ AJ781136/ AJ781137/ AJ781138/ AJ781139/ AJ781140/ AJ781141/ AJ781142/ AJ781143/ AJ781144/ AJ781145/ AJ781146/ AJ781147/ AJ781148/ AJ781149/ AJ781150/ AJ781151/ AJ781152/ AJ781153/ AJ781154/ AJ781155/ AJ781156/ AJ781157/ AJ781158/ AJ781159/ AJ781160/ AJ781161/ AJ781486/ AJ781487/ AJ781488/ AJ781489/ AJ781490/ AJ781491/ AJ781492/ AJ781493/ AJ781494/ AJ781495/ AJ781496/ AJ781497/ AJ783307/ AJ783308/ AJ783309/ AJ783310/ AJ783311/ AJ783312/ AJ783313/ AJ783314/ AJ783315/ AJ783316/ AJ783317/ AJ783318/ AJ783319/ AJ783320/ AJ783321/ AJ783322/ AJ783323/ AJ783324/ AJ783325/ AJ783326/ AJ783327/ AJ783328/ AJ783329/ AJ783330/ AJ783331/ AJ783332/ AJ783333/ AJ783334/ AJ783675/ AJ783676/ AJ783677/ AJ783678/ AJ783679/ AJ783680/ AJ783681/ AJ783682/ AJ783683/ AJ783684/ AJ783685/ AJ783686/ AJ783687/ AJ783688/ AJ783689/ AJ783690/ AJ783691/ AJ783692/ AJ783693/ AJ783694/ AJ783695/ AJ783696/ AJ783697/ AJ783698/ AJ783699/ AJ783700/ AJ783701/ AJ783702/ AJ783703
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Toxins; 0 / DNA, Bacterial; 0 / DNA, Ribosomal; 0 / Peptides, Cyclic; 0 / Proteins; 0 / RNA, Ribosomal, 16S; 0 / gas vesicle protein; 118399-22-7 / nodularin
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100. Fine AP: Laparoscopic repair of inguinal hernia using Surgisis mesh and fibrin sealant. JSLS; 2006 Oct-Dec;10(4):461-5
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  • This case series involved 38 adult patients with 51 inguinal hernias treated in a primary care center.
  • METHODS: Between December 2002 and May 2005, 38 patients with 45 primary and 6 recurrent inguinal hernias were treated with laparoscopic repair by the total extraperitoneal mesh placement (TEP) technique using Surgisis mesh secured into place with fibrin sealant.
  • CONCLUSIONS: Laparoscopic repair of inguinal hernia using Surgisis mesh secured with fibrin sealant can be effectively used to treat primary, recurrent, direct, indirect, and bilateral inguinal hernias in adults without complications and minimal recurrence within 1-year of follow-up.

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  • (PMID = 17575758.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive
  • [Other-IDs] NLM/ PMC3015740
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