[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 41 of about 41
2
Advertisement
4. Claahsen-van der Grinten HL, Otten BJ, Takahashi S, Meuleman EJ, Hulsbergen-van de Kaa C, Sweep FC, Hermus AR: Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients. J Clin Endocrinol Metab; 2007 Feb;92(2):612-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients.
  • CONTEXT: In male patients with congenital adrenal hyperplasia (CAH), testicular adrenal rest tumors (TART) are frequently present.
  • These tumors can interfere with testicular function.
  • Intensifying glucocorticoid therapy does not always lead to tumor regression and improvement of testicular function.
  • OBJECTIVE: The aim of this study was to evaluate tumor volume, symptoms, and pituitary-gonadal function in male patients with CAH caused by 21-hydroxylase deficiency and bilateral TART before and after testis-sparing surgery.
  • MAIN OUTCOME MEASURES: The main outcome measures were absence of residual tumor and improvement of symptoms and pituitary-gonadal function.
  • RESULTS: Residual tumors were not found on any of the patients' magnetic resonance imaging after surgery.
  • CONCLUSION: Testis-sparing surgery did not improve pituitary-gonadal function despite successful removal of the tumors.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / surgery. Adrenal Rest Tumor / surgery. Pituitary Gland / physiology. Testicular Neoplasms / surgery. Testis / physiology. Testis / surgery


25. Nagamine WH, Mehta SV, Vade A: Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia: sonographic and magnetic resonance imaging findings. J Ultrasound Med; 2005 Dec;24(12):1717-20
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia: sonographic and magnetic resonance imaging findings.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / pathology. Adrenal Hyperplasia, Congenital / ultrasonography. Adrenal Rest Tumor / pathology. Adrenal Rest Tumor / ultrasonography. Testicular Neoplasms / pathology. Testicular Neoplasms / ultrasonography


34. Fernandes VO, Barros AI, Quidute AR, Montenegro AP, Fontenele EG, Sales AP, Montenegro RM, Ferreira FV, Montenegro RM Jr: [Bilateral testicular tumors caused by congenital adrenal rest hyperplasia]. Arq Bras Endocrinol Metabol; 2009 Nov;53(8):1052-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Bilateral testicular tumors caused by congenital adrenal rest hyperplasia].
  • [Transliterated title] Tumores testiculares bilaterais por hiperplasia congĂȘnita de restos adrenais.
  • OBJECTIVES: Testicular tumors are a rare condition associated with congenital adrenal hyperplasia (CAH), originated from intratesticular adrenal rest tumors, and they are rarely associated with malignant tumors.
  • Their histological differentiation from Leydig-cell tumors is quite difficult, which would lead to inappropriate orchiectomies.
  • METHODS: Reported the case of 16-yr-old boy with previous diagnosis of CAH with bilateral testicular enlargement who was recommended to be submitted to a bilateral orchiectomy.
  • CONCLUSION: This case shows the importance of intratesticular adrenal rest tumors in the differential diagnosis of testicular tumors.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / pathology. Adrenal Rest Tumor / pathology. Leydig Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Agents, Hormonal / therapeutic use. Diagnosis, Differential. Humans. Male. Prednisone / therapeutic use


35. Mönig H, Sippell W: Congenital adrenal hyperplasia in adulthood: do men need to continue treatment? Horm Res; 2005;64 Suppl 2:71-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital adrenal hyperplasia in adulthood: do men need to continue treatment?
  • Due to early diagnosis and appropriate paediatric treatment, internists and endocrinologists are now caring for an increasing number of adult patients with congenital adrenal hyperplasia (CAH).
  • Problems that may be encountered in adult males with CAH are the continuing risk of developing an adrenal crisis and impaired gonadal function due to suppression of the hypothalamic-gonadal axis.
  • Fertility may be further compromised by testicular adrenal rest tumours.
  • Similar to female CAH patients, male patients may develop adrenal tumours due to inadequate adrenocorticotropic hormone suppression.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / drug therapy
  • [MeSH-minor] Adrenal Gland Neoplasms / etiology. Adrenal Insufficiency / etiology. Adult. Child. Fludrocortisone / therapeutic use. Humans. Hydrocortisone / therapeutic use. Hypertrophy / etiology. Infant. Infertility, Male / etiology. Male. Testis / pathology


36. Otten BJ, Stikkelbroeck MM, Claahsen-van der Grinten HL, Hermus AR: Puberty and fertility in congenital adrenal hyperplasia. Endocr Dev; 2005;8:54-66
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Puberty and fertility in congenital adrenal hyperplasia.
  • Congenital adrenal hyperplasia (CAH) is a disorder of adrenal steroid synthesis.
  • Adrenal progestagens and androgens are the main cause of disturbed ovarian activity.
  • In males, the main cause of subfertiltiy is the presence of testicular adrenal rest tumors, which are thought to originate from aberrant adrenal tissue and respond to treatment with glucocorticoids.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / physiopathology. Fertility / physiology. Puberty / physiology


37. Fenichel P, Bstandig B, Roger C, Chevallier D, Michels JF, Sadoul JL, Hieronimus S, Brucker-Davis F: Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma. Ann Endocrinol (Paris); 2008 Nov;69(5):453-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma.
  • Testicular adrenal rest tumours are frequently associated with congenital adrenal hyperplasia (CAH).
  • These ACTH-dependent tumours cannot be easily distinguished histologically from Leydig-cell tumours.
  • We report the case of a 30-year-old man who was explored for infertility, azoospermia and unilateral testicular tumour.
  • High levels of 17-OH progesterone and ACTH, low cortisol and undetectable gonadotropins levels, associated to bilateral adrenal hyperplasia, led to the diagnosis of CAH by 21-OH deficiency with a composite heterozygoty.
  • The testicular tumour was first considered as adrenal rest.
  • However, histological analysis of this unilateral painful tumour showed a steroid-hormone-secreting cell proliferation with atypical and frequent mitosis.
  • To discriminate between a benign adrenal rest tumour and a possible malignant leydigioma, tumoral expression of specific gene products was analyzed by RT-PCR.
  • No 11-beta-hydroxylase nor ACTH receptor mRNAs could be found in the tumour, which did not behave like usual adrenal rest cells.
  • For this unilateral testicular tumour, the lack of adrenal-specific markers associated with a high rate of mitosis and pleiomorphism supported a leydigian origin with malignant potential.
  • However, lack of tumoral LH-R mRNA expression and a tumour-free 3-year follow-up led us to retain the diagnosis of adrenal rest tumour with loss of adrenal gene expression and progressive autonomous behaviour.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / complications. Adrenal Hyperplasia, Congenital / diagnosis. Adrenal Rest Tumor / diagnosis. Leydig Cell Tumor / diagnosis. Testicular Neoplasms / complications. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adrenal Cortex Hormones / blood. Adrenal Cortex Hormones / genetics. Adult. Anti-Inflammatory Agents / therapeutic use. Azoospermia / etiology. Biomarkers, Tumor. Dexamethasone / therapeutic use. Diagnosis, Differential. Gonadal Steroid Hormones / blood. Gonadal Steroid Hormones / genetics. Gonadotropins / blood. Humans. Infertility, Male / etiology. Male. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Testis / pathology


38. Claahsen-van der Grinten HL, Stikkelbroeck NM, Sweep CG, Hermus AR, Otten BJ: Fertility in patients with congenital adrenal hyperplasia. J Pediatr Endocrinol Metab; 2006 May;19(5):677-85
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fertility in patients with congenital adrenal hyperplasia.
  • Congenital adrenal hyperplasia (CAH) is generally regarded as a paediatric endocrine disease, but nowadays nearly all patients reach adulthood as a result of improved diagnosis and treatment.
  • In males with CAH the fertility rate is reduced compared with the normal population, the most frequent cause being testicular adrenal rest tumours.
  • Development and growth of these tumours is assumed to be ACTH dependent and undertreatment may play an important role.
  • If intensifying glucocorticoid treatment does not lead to tumour decrease, surgical intervention may be considered, but the effect on fertility is not yet known.
  • Age of menarche and regularity of the menstrual cycle depends on the degree of adrenal suppression.
  • Not only adrenal androgens have to be normalised but also the levels of adrenal progestins (progesterone and 17-OH-progesterone) that interfere with normal ovulatory cycles.
  • Other factors that contribute to impaired fertility in females with CAH are ovarian hyperandrogenism (polycystic ovary syndrome), ovarian adrenal rest tumours, genital surgery and psychological factors.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / complications. Fertility / physiology


39. Collet TH, Pralong FP: Reversal of primary male infertility and testicular adrenal rest tumors in salt-wasting congenital adrenal hyperplasia. J Clin Endocrinol Metab; 2010 May;95(5):2013-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reversal of primary male infertility and testicular adrenal rest tumors in salt-wasting congenital adrenal hyperplasia.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / drug therapy. Fludrocortisone / therapeutic use. Pregnenediones / therapeutic use
  • [MeSH-minor] Addison Disease. Adrenal Rest Tumor / drug therapy. Adrenal Rest Tumor / pathology. Adult. Dexamethasone / therapeutic use. Exons. Humans. Infertility, Male / etiology. Male. Mutation, Missense. Patient Compliance. Steroid 21-Hydroxylase / genetics


40. Claahsen-van der Grinten HL, Otten BJ, Sweep FC, Hermus AR: Repeated successful induction of fertility after replacing hydrocortisone with dexamethasone in a patient with congenital adrenal hyperplasia and testicular adrenal rest tumors. Fertil Steril; 2007 Sep;88(3):705.e5-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeated successful induction of fertility after replacing hydrocortisone with dexamethasone in a patient with congenital adrenal hyperplasia and testicular adrenal rest tumors.
  • OBJECTIVE: To report repeated successful induction of fertility in an adult male patient with congenital adrenal hyperplasia (CAH) and testicular adrenal rest tumors (TART).
  • In an attempt to decrease tumor size and improve testicular function, his glucocorticoid medication was changed from hydrocortisone to an equivalent dosage of DXM.
  • CONCLUSION(S): In male CAH patients with testicular adrenal rest tumors, infertility may be reversible by replacing hydrocortisone with short courses of an equivalent dosage of DXM.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / complications. Dexamethasone / therapeutic use. Fertility / physiology. Hydrocortisone / therapeutic use. Testicular Neoplasms / complications


41. Claahsen-van der Grinten HL, Hermus AR, Otten BJ: Testicular adrenal rest tumours in congenital adrenal hyperplasia. Int J Pediatr Endocrinol; 2009;2009:624823
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular adrenal rest tumours in congenital adrenal hyperplasia.
  • In adult patients with congenital adrenal hyperplasia (CAH), the presence of testicular adrenal rest tumours (TART) is an important complication leading to gonadal dysfunction and infertility.
  • These tumours can be already found in childhood and puberty.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Dis Child. 1963 Sep;106:243-50 [14057603.001]
  • [Cites] BJU Int. 2005 Feb;95(3):407-10 [15679804.001]
  • [Cites] Hum Reprod. 1998 Dec;13(12):3402-5 [9886523.001]
  • [Cites] J Urol. 1998 Nov;160(5):1838-41 [9783971.001]
  • [Cites] Curr Opin Pediatr. 1997 Aug;9(4):443-6 [9300205.001]
  • [Cites] J Urol. 1997 Apr;157(4):1460-3 [9120982.001]
  • [Cites] Radiology. 1996 Jan;198(1):99-104 [8539414.001]
  • [Cites] J Clin Endocrinol Metab. 1994 Nov;79(5):1390-4 [7962333.001]
  • [Cites] Pediatr Radiol. 1991;21(4):284-7 [1870928.001]
  • [Cites] Radiology. 1992 May;183(2):425-9 [1561344.001]
  • [Cites] Histopathology. 1991 Nov;19(5):468-70 [1757086.001]
  • [Cites] J Clin Endocrinol Metab. 1991 Nov;73(5):1129-33 [1939529.001]
  • [Cites] Fertil Steril. 1987 Apr;47(4):664-70 [3032693.001]
  • [Cites] Am J Surg Pathol. 1988 Jul;12(7):503-13 [3291624.001]
  • [Cites] Fertil Steril. 2008 Mar;89(3):597-601 [17543962.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Dec;92(12):4583-9 [17895312.001]
  • [Cites] Fertil Steril. 2007 Sep;88(3):705.e5-8 [17517401.001]
  • [Cites] J Clin Endocrinol Metab. 1990 May;70(5):1408-13 [2335578.001]
  • [Cites] Fertil Steril. 1983 Dec;40(6):809-14 [6317470.001]
  • [Cites] N Engl J Med. 1978 Dec 21;299(25):1392-6 [152409.001]
  • [Cites] Arch Pathol. 1973 Mar;95(3):160-4 [4686507.001]
  • [Cites] Hum Reprod Update. 2004 Nov-Dec;10(6):469-85 [15514016.001]
  • [Cites] J Pediatr Endocrinol Metab. 2004 Apr;17(4):645-53 [15198296.001]
  • [Cites] N Engl J Med. 2003 Aug 21;349(8):776-88 [12930931.001]
  • [Cites] Eur Radiol. 2003 Jul;13(7):1597-603 [12835972.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Dec;86(12):5721-8 [11739428.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Jul;86(7):3070-8 [11443169.001]
  • [Cites] J Pediatr Endocrinol Metab. 2001 Apr;14(4):415-9 [11327375.001]
  • [Cites] Hum Reprod. 2001 Feb;16(2):263-7 [11157817.001]
  • [Cites] Eur Radiol. 2000;10(7):1165-8 [11003415.001]
  • [Cites] Urol Clin North Am. 2000 Aug;27(3):519-28, x [10985151.001]
  • [Cites] J Endocrinol Invest. 2000 Jan;23(1):23-7 [10698047.001]
  • [Cites] AJR Am J Roentgenol. 1999 Apr;172(4):1003-6 [10587136.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Sep;92(9):3674-80 [17595257.001]
  • [Cites] Eur J Endocrinol. 2007 Sep;157(3):339-44 [17766717.001]
  • [Cites] Horm Res. 2007;67(6):284-91 [17199092.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Feb;92(2):612-5 [17090637.001]
  • [Cites] Dev Biol. 2006 Nov 1;299(1):250-6 [16949566.001]
  • [Cites] J Pediatr Endocrinol Metab. 2006 May;19(5):677-85 [16789634.001]
  • [Cites] Endocr Pathol. 2006 Spring;17(1):83-7 [16760584.001]
  • [Cites] Pediatr Surg Int. 2005 Oct;21(10):853-5 [16180005.001]
  • [Cites] J Steroid Biochem Mol Biol. 2005 Jan;93(1):67-72 [15748834.001]
  • [Cites] Endocr Dev. 2005;8:54-66 [15722617.001]
  • [Cites] Eur J Endocrinol. 1999 Sep;141(3):231-7 [10474120.001]
  • (PMID = 19956703.001).
  • [ISSN] 1687-9856
  • [Journal-full-title] International journal of pediatric endocrinology
  • [ISO-abbreviation] Int J Pediatr Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2777016
  •  go-up   go-down






Advertisement