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1. Chiou TT, Chiang PH, Fuh M, Liu RT, Lee WC, Lee WC, Ng HY, Tsai YC, Chuang FR, Huang CC, Lee CT: Factors determining cardiovascular and renal outcomes after adrenalectomy in patients with aldosterone-producing adrenal adenoma. Tohoku J Exp Med; 2009 May;218(1):17-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors determining cardiovascular and renal outcomes after adrenalectomy in patients with aldosterone-producing adrenal adenoma.
  • Primary aldosteronism is an important cause of secondary hypertension, because it is potentially curable, especially in case of unilateral aldosterone-producing adrenal adenoma (APA).
  • However, the information is limited concerning the cardiovascular and renal outcomes in this patient population.
  • We studied 52 patients with APA in order to determine the pre-operative and post-operative factors predicting cardiovascular and renal outcomes.
  • Patients whose renal function worsened after adrenalectomy had significantly higher pre-operative plasma active renin levels.
  • Thus, in patients with APA, the presence of LVH is correlated with impaired renal function (lower eGFR).
  • In conclusion, pre-operative BP and post-operative plasma aldosterone are important in predicting post-adrenalectomy hypertension, and a lower pre-operative plasma renin predicts the improvement in renal function after adrenalectomy.
  • [MeSH-major] Adrenal Cortex Neoplasms. Adrenalectomy. Adrenocortical Adenoma. Aldosterone / blood. Cardiovascular System / metabolism. Hypertension. Kidney

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  • (PMID = 19398869.001).
  • [ISSN] 1349-3329
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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2. Arai H, Kobayashi N, Nakatsuru Y, Masuzaki H, Nambu T, Takaya K, Yamanaka Y, Kondo E, Yamada G, Fujii T, Miura M, Komatsu Y, Kanamoto N, Ariyasu H, Moriyama K, Yasoda A, Nakao K: A case of cortisol producing adrenal adenoma without phenotype of Cushing's syndrome due to impaired 11beta-hydroxysteroid dehydrogenase 1 activity. Endocr J; 2008 Aug;55(4):709-15
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  • [Title] A case of cortisol producing adrenal adenoma without phenotype of Cushing's syndrome due to impaired 11beta-hydroxysteroid dehydrogenase 1 activity.
  • This report concerns a case of cortisol-producing adrenocortical adenoma without the phenotype of Cushing's syndrome.
  • A left adrenal tumor was incidentally detected in this patient.
  • A diagnosis of adrenal Cushing's syndrome was based on the results of endocrinological and radiological examinations, although she showed none of the physical signs of Cushing's syndrome, glucose intolerance, hypertension or dyslipidermia.
  • After a successful laparoscopic left adrenalectomy, the pathological diagnosis was adrenocortical adenoma.
  • Slow tapering of glucocorticoids was needed to prevent adrenal insufficiency after surgery, and the plasma ACTH level remained high even though the serum cortisol level had reached the upper limit of the normal range.
  • [MeSH-major] 11-beta-Hydroxysteroid Dehydrogenase Type 1 / metabolism. Adrenal Cortex Neoplasms / physiopathology. Adrenocortical Adenoma / physiopathology

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  • (PMID = 18493111.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 1.1.1.146 / 11-beta-Hydroxysteroid Dehydrogenase Type 1; WI4X0X7BPJ / Hydrocortisone
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3. Hori T, Taniguchi K, Kurata M, Nakamura K, Kato K, Ogura Y, Iwasaki M, Okamoto S, Yamakado K, Yagi S, Iida T, Kato T, Saito K, Wang L, Kawarada Y, Uemoto S: Carcinoembryonic antigen-producing adrenal adenoma resected using combined lateral and anterior transperitoneal laparoscopic surgery. World J Gastroenterol; 2007 Dec 7;13(45):6094-7
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  • [Title] Carcinoembryonic antigen-producing adrenal adenoma resected using combined lateral and anterior transperitoneal laparoscopic surgery.
  • Computed tomography detected a left adrenal mass measuring 3.5 cm multiply 3.0 cm in diameter.
  • Fluorodeoxyglucose positron emission tomography showed increased uptake in the adrenal tumor only, with a maximum standardized uptake value of 2.8.
  • A diagnosis of CEA-producing benign adenoma was made.
  • Histopathological examination revealed a benign adenoma.
  • We present, to the best of our knowledge, the first case of CEA-producing adrenal adenoma, along with a review of the relevant literature, and discuss our laparoscopic surgery techniques.
  • [MeSH-major] Adenoma / blood. Adrenal Gland Neoplasms / blood. Carcinoembryonic Antigen / blood. Laparoscopy / methods

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  • (PMID = 18023107.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
  • [Number-of-references] 11
  • [Other-IDs] NLM/ PMC4250898
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4. Greven WL, van Bemmel T: Rare oxygen, a rare way to diagnose Conn's syndrome. NDT Plus; 2008 Dec;1(6):427-428

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  • [Title] Rare oxygen, a rare way to diagnose Conn's syndrome.
  • We present a case of a patient with symptoms of mountain sickness at relatively low altitudes, who appeared to have Conn's syndrome (primary hyperaldosteronism). <b>Case.
  • A CT scan of the abdomen revealed an adenoma in the left adrenal gland.

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  • [Cites] BMJ. 2003 Apr 26;326(7395):915-9 [12714473.001]
  • [Cites] Ann Intern Med. 2004 Nov 16;141(10):789-800 [15545679.001]
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  • (PMID = 28657013.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Conn's syndrome / hyperaldosteronism / mountain sickness
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5. Martin JT, Alkhoury F, Helton S, Fiedler P, Sakharova O, Yood S: Metastatic adenocarcinoma within a functioning adrenal adenoma: a case report. Cases J; 2009;2:7965

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenocarcinoma within a functioning adrenal adenoma: a case report.
  • We present the case of a 54-year-old woman who underwent right adrenalectomy for palliation of Cushing's symptoms.
  • Pathologic findings revealed a 5 cm adrenal adenoma with a metastatic adenocarcinoma deposit.
  • The occurrence of tumor-to-tumor metastasis is rare, and the finding of a metastasis within a functional adrenal adenoma exceptionally so.
  • Previously reported incidences of this finding in patients with lung cancer range from 0.14% to 0.63%.
  • We review the literature regarding this unusual finding.

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  • (PMID = 19830028.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC2740135
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6. Terzolo M, Bovio S, Pia A, Conton PA, Reimondo G, Dall'Asta C, Bemporad D, Angeli A, Opocher G, Mannelli M, Ambrosi B, Mantero F: Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma. Eur J Endocrinol; 2005 Aug;153(2):307-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma.
  • OBJECTIVE: There is scant information on the morbidity associated with subclinical Cushing's syndrome in patients with a clinically inapparent adrenal adenoma.
  • In the present study, we have determined the prevalence of alterations of the hypothalamic-pituitary-adrenal axis in such patients and examined whether any correlation between endocrine data and the clinical phenotype exists.
  • DESIGN AND METHODS: A multi-institutional retrospective study was carried out on 210 patients (135 women and 75 men aged 19-81 years) with an adrenal adenoma detected serendipitously between 1996 and 2000 in four referral centers in Italy.
  • CONCLUSIONS: Elevated midnight cortisol concentration is a reliable test to select a subgroup of patients with a clinically inapparent adrenal adenoma with an adverse cardiovascular risk profile.

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  • (PMID = 16061838.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 57B09Q7FJR / Dehydroepiandrosterone Sulfate; WI4X0X7BPJ / Hydrocortisone
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7. Park SH, Kim MJ, Kim JH, Lim JS, Kim KW: Differentiation of adrenal adenoma and nonadenoma in unenhanced CT: new optimal threshold value and the usefulness of size criteria for differentiation. Korean J Radiol; 2007 Jul-Aug;8(4):328-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiation of adrenal adenoma and nonadenoma in unenhanced CT: new optimal threshold value and the usefulness of size criteria for differentiation.
  • OBJECTIVE: To determine the optimal threshold for the attenuation values in unenhanced computed tomography (CT) and assess the value of the size criteria for differentiating between an adrenal adenoma and a nonadenoma.
  • MATERIALS AND METHODS: The unenhanced CT images of 45 patients at our institution, who underwent a surgical resection of an adrenal masses between January 2001 and July 2005, were retrospectively reviewed.
  • Forty-five adrenal masses included 25 cortical adenomas, 12 pheochromocytomas, three lymphomas, and five metastases confirmed by pathology were examined.
  • The mean attenuation values of an adrenal adenoma and nonadenoma were compared using an unpaired t test.
  • RESULTS: The twenty-five adenomas showed significantly lower (p < 0.05) attenuation values (mean+/-SD; 16.3+/-14.9) than the nonadenomas (38.1+/-6.8).
  • The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for diagnosing adenomas were 36%, 100%, 100%, 56%, and 64%, respectively, at a threshold of 10 HU; 60%, 100%, 100%, 67%, and 78%, respectively, at a threshold of 20 HU; and 72%, 95%, 95%, 73%, and 82%, respectively, at a threshold of 25 HU.
  • The adenomas had a significantly (p < 0.05) smaller diameter (2.44+/-1.24 cm) than the nonadenomas (5.09+/-2.37 cm).
  • CONCLUSION: The threshold attenuation values of 20 or 25 HU in the unenhanced CT appear optimal for discriminating an adrenal adenoma from a nonadenoma.
  • The size criteria are of little value in differentiating adrenal masses because of their low specificity or low sensitivity.
  • [MeSH-major] Adenoma / radiography. Adrenal Gland Neoplasms / radiography

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  • (PMID = 17673844.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627166
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8. Wolf A, Willenberg HS, Cupisti K, Schott M, Geddert H, Raffel A, Bornstein SR, Scherbaum WA, Knoefel WT: Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management. Horm Metab Res; 2005 Jun;37(6):391-5
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  • [Title] Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management.
  • There is evidence for a close interrelation between the adrenomedullary and adrenocortical tissues, and there are well-characterized models of their paracrine interaction.
  • To contribute to the studies of systemic interactions between these tissues, we studied a 52-year-old female patient with a pheochromocytoma and a contralateral cortisol-producing adenoma.
  • Due to a misunderstanding, she presented to her family doctor to have an inherited kidney disease ruled out.
  • An adrenal mass was discovered incidentally by ultrasound.
  • A computerized tomography of the abdomen revealed bilateral adrenal masses.
  • Laboratory work-up, selective adrenal venous sampling and magnetic resonance imaging studies established the diagnosis of a pheochromocytoma in the right-hand adrenal gland and a cortisol-producing adenoma on the left.
  • Immunohistochemistry showed positive staining against chromogranin A in a histological specimen obtained from the right-hand adrenal gland, while the left was negative; the left-hand adrenal gland stained positive against the ACTH receptor (MC2R) while the right was negative.
  • Genetically, the patient was negative for MEN2, von Hippel-Lindau disease, and mutations in subunits B, C, and D of the succinate dehydrogenase gene.
  • Although presence of bilateral adrenal adenomas or bilateral adrenal pheochromocytomas in certain inherited disorders are possible, this rare case of an adrenal pheochromocytoma combined with a contralateral cortisol-producing adrenal adenoma may further underline the wide range of complex interactions between the two endocrine systems.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Pheochromocytoma / radiography

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  • (PMID = 16001333.001).
  • [ISSN] 0018-5043
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
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9. Rossi E, Foroni M, Regolisti G, Perazzoli F, Negro A, Santi R, Grasselli C, Galli P, Gardini G: Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. Am J Hypertens; 2008 Nov;21(11):1269-72
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  • [Title] Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Carcinoma, Renal Cell / complications. Cushing Syndrome / diagnosis. Hyperaldosteronism / diagnosis. Kidney Neoplasms / complications


10. Yoon JK, Remer EM, Herts BR: Incidental pheochromocytoma mimicking adrenal adenoma because of rapid contrast enhancement loss. AJR Am J Roentgenol; 2006 Nov;187(5):1309-11
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  • [Title] Incidental pheochromocytoma mimicking adrenal adenoma because of rapid contrast enhancement loss.
  • [MeSH-major] Adenoma / radiography. Adrenal Gland Neoplasms / radiography. Contrast Media. Incidental Findings. Pheochromocytoma / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Barrett Esophagus / complications. Diagnosis, Differential. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / etiology. Fluorodeoxyglucose F18. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 17056921.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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11. Yan QZ, Li HZ, Pan DL: [Causes of delaying diagnosis of primary hyperaldosteronism with adrenal adenoma and strategy therefore]. Zhonghua Yi Xue Za Zhi; 2006 Nov 14;86(42):3002-4
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  • [Title] [Causes of delaying diagnosis of primary hyperaldosteronism with adrenal adenoma and strategy therefore].
  • OBJECTIVE: To analyze the causes of delaying diagnosis of primary hyperaldosteronism with adrenal adenoma and discuss corrective strategies.
  • METHODS: The clinical data of 267 patients of primary hyperaldosteronism with adrenal adenoma confirmed by operation 1995 - 2005 were analyzed.
  • RESULTS: Confirmed diagnosis was made after a duration of (92 +/- 64) months (3 - 40 years) after the first visit.
  • 95.9% of the patients were diagnosed as with primary hypertension at the first visit without receiving relevant imaging examination of adrenal and endocrine examination.
  • Adrenal adenoma was discovered by computed tomography with thin coat screening in 267 patients and by ultrasonography in 151 patients.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Hyperaldosteronism / diagnosis
  • [MeSH-minor] Adult. Aged. Aldosterone / blood. Biomarkers, Tumor / blood. Chymosin / blood. Early Diagnosis. Female. Humans. Hypertension / diagnosis. Hypokalemia / diagnosis. Male. Mass Screening / methods. Middle Aged. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Time Factors. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 17288816.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 4964P6T9RB / Aldosterone; EC 3.4.23.4 / Chymosin
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12. Ors F, Lev-Toaff A, O'Kane P, Qazi N, Bergin D: Paraovarian adrenal rest with MRI features characteristic of an adrenal adenoma. Br J Radiol; 2007 Sep;80(957):e205-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraovarian adrenal rest with MRI features characteristic of an adrenal adenoma.
  • We report MR and sonographic imaging features of an incidentally detected paraovarian adrenal rest in a 44-year-old woman who was being evaluated for menorrhagia.
  • This is the first report of chemical shift imaging identifying the presence of lipid within an adrenal rest as well as rapid washout of contrast.
  • Both of these MR characteristics are typically seen with an adrenal adenoma.
  • [MeSH-major] Adrenal Rest Tumor / diagnosis. Fallopian Tube Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / ultrasonography. Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / ultrasonography. Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 17928489.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Kulkarni M, Joshi SR: Chemical shift imaging in diagnosis of adrenal adenoma. J Assoc Physicians India; 2006 Jan;54:34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemical shift imaging in diagnosis of adrenal adenoma.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Lipids / analysis. Magnetic Resonance Imaging. Male. Pheochromocytoma / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16649736.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Lipids
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14. Qiao ZW, Xia CM, Zhu YB, Shi WP, Miao F: First-pass perfusion computed tomography: initial experience in differentiating adrenal adenoma from metastasis. Eur J Radiol; 2010 Mar;73(3):657-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] First-pass perfusion computed tomography: initial experience in differentiating adrenal adenoma from metastasis.
  • OBJECTIVE: To differentiate adrenal adenoma from metastasis in patients using perfusion computed tomography (PCT) imaging.
  • METHODS: Thirty-two patients with adrenal masses underwent first-pass PCT imaging.
  • Of these patients, twenty-one were diagnosed with adrenal adenoma, and the others with metastases.
  • RESULTS: The perfusion parameters such as BV, BF and PS were statistically significant different between the two groups, with adenomas showing higher mean BV (12.18 versus 3.86), BF (97.51 versus 45.99) and PS (21.73 versus 10.93) compared with metastases (p<0.05).
  • For BV, a cutoff point of 7.30 was found to have a sensitivity of 95.2% and a specificity of 100% to differentiate between adenoma and metastasis.
  • The sensitivity and specificity were 81.0 and 80.0%, respectively, for BF with a cutoff point of 71.96; and 85.7 and 86.7%, respectively, for PS with a cutoff point of 12.70 to differentiate adenoma and metastasis.
  • A comparison of MVD counts from adenomas with those from metastases showed a significant difference (p<0.05).
  • However, no significant differences were observed in the four perfusion parameters and MVD between lipid rich and lipid poor adenomas.
  • CONCLUSION: PCT may be useful for evaluating the neovascularization of adrenal masses and differentiating adenoma from metastasis on the basis of PCT parameters.
  • Adenomas show higher BV, BF and PS compared with metastases.
  • According our data, the optimal threshold BV is 7.30, resulting in a sensitivity of 95.2% and a specificity of 100% for the differentiation of adenoma from metastasis.
  • Adrenal adenomas have similar hemodynamic profiles, which are apparently independent of the lipid content of an adenoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Adrenocortical Adenoma / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Male. Microcirculation. ROC Curve. Radiographic Image Interpretation, Computer-Assisted

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19200677.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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15. Quintos JB, Salas M: Virilizing adrenal adenoma in a 20 month-old girl. J Pediatr Endocrinol Metab; 2009 Sep;22(9):779-80

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  • [Title] Virilizing adrenal adenoma in a 20 month-old girl.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Virilism / etiology

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  • (PMID = 19960887.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. De Padua M, Rajagopal V: Myxoid adrenal adenoma with focal pseudoglandular pattern. Indian J Med Sci; 2008 May;62(5):199-203

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid adrenal adenoma with focal pseudoglandular pattern.
  • Adrenal cortical tumors with myxoid change are rare tumors.
  • To our knowledge, only 22 cases have been described so far in literature, which include 13 carcinomas and 9 adenomas.
  • We report a case of a myxoid adenoma of the left adrenal gland in a 67-year-old woman, with a focal pseudoglandular pattern involving about 20% of the studied tumor.
  • Immunophenotype was consistent with an adrenal tumor, i.e., positive for vimentin, inhibin, and melan A.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology

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  • (PMID = 18579979.001).
  • [ISSN] 0019-5359
  • [Journal-full-title] Indian journal of medical sciences
  • [ISO-abbreviation] Indian J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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17. Chitalia N, Weeg N, Antonios TF: Aldosterone-producing adrenal adenoma and idiopathic intracranial hypertension--a pathogenetic link for aldosterone? QJM; 2010 Sep;103(9):699-702
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aldosterone-producing adrenal adenoma and idiopathic intracranial hypertension--a pathogenetic link for aldosterone?
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Aldosterone / secretion. Hyperaldosteronism / complications. Pseudotumor Cerebri / etiology

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  • (PMID = 20179082.001).
  • [ISSN] 1460-2393
  • [Journal-full-title] QJM : monthly journal of the Association of Physicians
  • [ISO-abbreviation] QJM
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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18. Pittavini L, De Gaetano A, Solano G, Losito A: Resistant arterial hypertension: association with syncronous kidney cancer and adrenal adenoma. J Nephrol; 2010 Sep-Oct;23(5):614-6
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  • [Title] Resistant arterial hypertension: association with syncronous kidney cancer and adrenal adenoma.
  • The coexistence of renal cancer and adrenal adenoma is rare.
  • We report the case of a 60-year-old patient with synchronous hypernephroma and adrenal adenoma.
  • This suggests that the coexistence of kidney cancer and adrenal adenoma may be a curable cause of resistant hypertension.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Carcinoma, Renal Cell / complications. Hypertension / etiology. Kidney Neoplasms / complications. Neoplasms, Multiple Primary / complications


19. Alam MM, Rahman MA, Naser MF, Hossain MS, Islam MA: Testosterone secreting adrenal adenoma in an adult female patient. Mymensingh Med J; 2010 Oct;19(4):632-5
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  • [Title] Testosterone secreting adrenal adenoma in an adult female patient.
  • Adrenal tumours that secrete testosterone are extremely rare and we describe such a case in a 35 years old female with virilization.
  • She had left adrenal adenoma 7.5 X 6.4 cm in size, her ovaries were normal.
  • Histopathological examination confirmed the diagnosis of adrenal adenoma.

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  • (PMID = 20956912.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; 57B09Q7FJR / Dehydroepiandrosterone Sulfate
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20. Pomara G, Cappello F, Barzon L, Morelli G, Rappa F, Benvegna L, Giannarini G, Palù G, Selli C: Cytomegalovirus and BK-Virus co-infection of a clinically non-functioning adrenal adenoma: innocent bystanders or new pathogenetic agents? Eur J Histochem; 2006 Apr-Jun;50(2):131-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomegalovirus and BK-Virus co-infection of a clinically non-functioning adrenal adenoma: innocent bystanders or new pathogenetic agents?
  • We report a case of a 64-year-old woman who underwent left adrenalectomy with removal of a 8,5 cm clinically non-functioning adrenocortical adenoma and a 4-cm myelolipoma.
  • Molecular testing for viral infection demonstrated the presence of cytomegalovirus (CMV) DNA sequences in the adrenal adenoma, but not in the myelolipoma (confirmed by immunohistochemistry).
  • Moreover, the adrenal adenoma was also positive for parvovirus B19, and both adrenal tumor samples were positive for polyomavirus BK (BKV) and adenovirus DNA sequences.
  • This is the first report of co-infection of an adrenocortical adenoma by CMV and BKV.
  • The role of these viruses in adrenal tumorigenesis was postulated.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenocortical Adenoma / pathology. BK Virus / genetics. Cytomegalovirus / genetics. Cytomegalovirus Infections / complications. Polyomavirus Infections / complications

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  • (PMID = 16864124.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Italy
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21. Szentirmai O, Winston KR, Jedlicka P, Lum GM: Spontaneous intracerebral hemorrhage in a child with systemic hypertension and adrenal adenoma. Case report. J Neurosurg; 2007 Oct;107(4 Suppl):328-9
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  • [Title] Spontaneous intracerebral hemorrhage in a child with systemic hypertension and adrenal adenoma. Case report.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Basal Ganglia / blood supply. Cerebral Hemorrhage / etiology. Hypertension / complications. Hypertension / etiology

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  • (PMID = 17941500.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents
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22. Prince EA, Yoo DC, DeLellis RA, Mayo-Smith WW: CT and PET appearance of a pigmented "black" adrenal adenoma in a patient with lung cancer. Clin Radiol; 2007 Dec;62(12):1229-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CT and PET appearance of a pigmented "black" adrenal adenoma in a patient with lung cancer.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / radionuclide imaging. Adenoma / radiotherapy. Adrenal Gland Neoplasms / radiography. Adrenal Gland Neoplasms / radionuclide imaging

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  • (PMID = 17981173.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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23. Garduno-García Jde J, Reza-Albarrán A, Márquez MA, Pérez FJ: [Adrenal adenoma as a cause of Cushing's syndrome: twenty years' experience in a referral center in Mexico]. Endocrinol Nutr; 2010 Nov;57(9):421-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adrenal adenoma as a cause of Cushing's syndrome: twenty years' experience in a referral center in Mexico].
  • [Transliterated title] Adenoma adrenal como etiología de síndrome de Cushing: veinte años de experiencia en un centro mexicano de tercer nivel.
  • Adrenal adenomas are an uncommon cause of adult CS.
  • OBJECTIVE: To describe the characteristics and outcome of patients with CS caused by adrenal adenomas in a referral center.
  • METHODS: We performed a retrospective cross-sectional observational study of patients with a diagnosis of CS caused by adrenal adenomas managed in our center over a 20-year period.
  • Our clinical experience in the diagnosis and treatment of this entity was analyzed.
  • The results of dynamic testing with dexamethasone suggested adrenal adenoma in 100% of the patients.
  • Seventy percent of adenomas were found in the left gland.
  • ACTH measurement in our center was not reliable in identifying adrenal adenoma as a cause of CS.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Cushing Syndrome / etiology

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  • [Copyright] Copyright © 2010 SEEN. Published by Elsevier Espana. All rights reserved.
  • (PMID = 20863774.001).
  • [ISSN] 1579-2021
  • [Journal-full-title] Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
  • [ISO-abbreviation] Endocrinol Nutr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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24. Yoon JH, Kim SH, Kim MA, Han JK, Choi BI: MDCT and Gd-EOB-DTPA enhanced MRI findings of adrenal adenoma arising from an ectopic adrenal gland within the liver: radiologic-pathologic correlation. Korean J Radiol; 2010 Jan-Feb;11(1):126-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MDCT and Gd-EOB-DTPA enhanced MRI findings of adrenal adenoma arising from an ectopic adrenal gland within the liver: radiologic-pathologic correlation.
  • We report a case of an adenoma arising from an ectopic adrenal gland mimicking a hepatocellular carcinoma in a heavy alcohol abuser.
  • A tumorectomy was performed and adrenal adenoma from an ectopic adrenal gland within the liver was confirmed.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Choristoma / diagnosis. Contrast Media. Gadolinium DTPA. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Glands. Carcinoma, Hepatocellular / diagnosis. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 20046505.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ PMC2799643
  • [Keywords] NOTNLM ; Adrenal adenoma / Ectopic adrenal gland / Liver / Magnetic resonance (MR) / Multi-detector computed tomography (MDCT)
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25. Monjero-Ares I, Gegundez-Gómez C, Couselo-Villanueva JM, Moreda-Pérez M, Jorge-Iglesias M, Torres-García I, Alvarez-Gutiérrez AE, Arija-Val JF: [Association of pheochromocytoma with contralateral nonfunctioning adrenal adenoma]. Cir Esp; 2006 Feb;79(2):126-8
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  • [Title] [Association of pheochromocytoma with contralateral nonfunctioning adrenal adenoma].
  • [Transliterated title] Asociación de feocromocitoma con adenoma suprarrenal contralateral no funcionante.
  • A 52-year-old woman complaining of abdominal pain, headaches and palpitations was admitted to our hospital for investigation of a bilateral adrenal tumor.
  • The definitive diagnosis was right pheochromocytoma and left adrenocortical adenoma.
  • Only four cases of pheochromocytoma associated with nonfunctioning adrenal adenoma have previously been reported.
  • [MeSH-major] Adenoma. Adrenal Gland Neoplasms. Neoplasms, Multiple Primary. Pheochromocytoma

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  • (PMID = 16539953.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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26. Ouzounian S, Tissier F, Gouya H, Kujas M, Louvel A, Legmann P, Bertagna X: [Cushing's syndrome and adrenal adenoma. Two surprising associations]. Presse Med; 2005 Apr 09;34(7):511-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cushing's syndrome and adrenal adenoma. Two surprising associations].
  • [Transliterated title] Maladie de Cushing et adénome cortico-surrénalien. Deux associations étonnantes.
  • CASES: In the first case, we describe the case of a patient with an adrenal adenoma 20 years before the occurrence of Cushing's disease related to the pineal gland.
  • In the second case, two members of the same family were diagnosed almost simultaneously with adrenal cortical adenoma (mother) and Cushing's disease (daughter).
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Cushing Syndrome / etiology

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  • (PMID = 15903005.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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27. Vesin C, Chabre O, Mallion JM, Chaffanjon P, Sturm N, Baguet JP: [Diagnosis and post-operative evolution of patients operated for adrenal adenoma (Conn syndrome). A 12-years retrospective study]. Arch Mal Coeur Vaiss; 2007 Feb;100(2):121-5

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  • [Title] [Diagnosis and post-operative evolution of patients operated for adrenal adenoma (Conn syndrome). A 12-years retrospective study].
  • [Transliterated title] Diagnostic et évolution postopératoire des patients opérés d'un adénome de Conn. Etude rétrospective sur 12 ans.
  • The prevalence and characteristics of patients operated for adrenal adenoma (Conn syndrome) as well as their post-operative arterial pressure evolution are varying through literature.
  • From 1993 to 2005, 24 patients (mean age = 46 +/-11 years) presented the biological criteria of primary hyperaldosteronism and benefited from adrenalectomy with confirmation of adrenal adenoma.
  • All adenomas measured more than 10 mm in scanner imaging.
  • Post-operative spontaneous normotensive patients had, at the diagnosis of adrenal adenoma, a more recent and non-refractory hypertension, with a lower number of antihypertensive drugs, a better response to spirinolactone and higher aldosterone plasmatic levels.
  • 1) Whether 70% of patients operated for adrenal adenoma are normotensive (with or without treatement) post-operatively, only 25% are definitely cured after 4 years.
  • Factors associated to a post-operative cure highlight the interest of an ealy diagnosis.
  • 2) There is probably an underdiagnosis of adrenal adenoma (Conn syndrome) because neither adenomas with normokaliemia, nor adenomas <10 mm in scanner imaging have ever been diagnosed or at least, sent to surgery.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / diagnosis. Adrenocortical Adenoma / surgery

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  • (PMID = 17474497.001).
  • [ISSN] 0003-9683
  • [Journal-full-title] Archives des maladies du coeur et des vaisseaux
  • [ISO-abbreviation] Arch Mal Coeur Vaiss
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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28. Linder B, Hong Y, Jarrett T: Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass. Int J Urol; 2009 Nov;16(11):912-4
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  • [Title] Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass.
  • We report a case of an adrenal rest arising in the kidney of a 37-year-old male.
  • Laparoscopic renal exploration and biopsy revealed angiomyolipoma on frozen section.
  • However, final pathological analysis of the partial nephrectomy specimen revealed intra-renal adrenal adenoma.
  • The diagnosis was confirmed by immunohistochemistries and transmission electron microscopy.
  • We review the reported literature on intra-renal adrenal adenoma and highlight the aspects that raise the index of suspicion for this entity on the differential diagnosis of renal masses.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 19863627.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 8
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29. Mahadevia S, Rozenblit A, Milikow D, Marinovich A: Renal-adrenal fusion: instance of an adrenal adenoma mimicking a solid renal mass at CT--case report. Radiology; 2009 Jun;251(3):808-12
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  • [Title] Renal-adrenal fusion: instance of an adrenal adenoma mimicking a solid renal mass at CT--case report.
  • The authors report an unusual case of unilateral renal-adrenal fusion with a concurrent adrenal adenoma.
  • At computed tomography, this abnormality appeared as a solid enhancing lesion in the upper pole of the kidney, mimicking a renal mass.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Kidney / abnormalities. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Kidney Diseases / radiography. Nephrectomy

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  • (PMID = 19261923.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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30. Wiederholt T, Megahed M: [Acne conglobata in adrenal adenoma]. Hautarzt; 2007 Nov;58(11):932-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acne conglobata in adrenal adenoma].
  • [Transliterated title] Acne conglobata bei Nebennierenadenom.
  • [MeSH-major] Acne Vulgaris / etiology. Adenoma / complications. Adrenal Gland Neoplasms / complications. Cushing Syndrome / diagnosis

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  • [Cites] Dermatology. 2003;206(1):11-6 [12566800.001]
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  • (PMID = 17952687.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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31. Nugent M, Waterman GS: An adrenal adenoma presenting with psychosis. Psychosomatics; 2006 Mar-Apr;47(2):175-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An adrenal adenoma presenting with psychosis.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / psychology. Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / psychology. Psychotic Disorders / diagnosis. Psychotic Disorders / etiology
  • [MeSH-minor] Adult. Antipsychotic Agents / therapeutic use. Diagnosis, Differential. Dibenzothiazepines / therapeutic use. Female. Humans. Quetiapine Fumarate

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  • (PMID = 16508033.001).
  • [ISSN] 0033-3182
  • [Journal-full-title] Psychosomatics
  • [ISO-abbreviation] Psychosomatics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antipsychotic Agents; 0 / Dibenzothiazepines; 2S3PL1B6UJ / Quetiapine Fumarate
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32. Aydin A, Okmen E, Erdinler I, Sanli A, Cam N: Adrenal adenoma presenting with ventricular fibrillation. Tex Heart Inst J; 2005;32(1):85-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal adenoma presenting with ventricular fibrillation.
  • We report the case of a 58-year-old man who presented with ventricular fibrillation.
  • Computed tomography then revealed a right adrenal mass.
  • The patient was treated with surgical resection of the adenoma.

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  • [Cites] Am J Cardiol. 1985 Aug 30;56(6):20D-23D [4036815.001]
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  • (PMID = 15902830.001).
  • [ISSN] 0730-2347
  • [Journal-full-title] Texas Heart Institute journal
  • [ISO-abbreviation] Tex Heart Inst J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC555832
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33. Horii R, Kahara T, Akahori H, Uchiyama A, Miwa A, Usuda R: Giant adrenal adenoma with hyperaldosteronism. Intern Med; 2006;45(2):109-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant adrenal adenoma with hyperaldosteronism.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Hyperaldosteronism / diagnosis. Hyperaldosteronism / etiology

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  • (PMID = 16484750.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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34. Herrera JD, Davidson JA, Mestman JH: Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. Endocr Pract; 2009 Mar;15(2):149-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature.
  • OBJECTIVE: To report a case of hyperandrogenism attributable to the presence of an adrenal adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman.
  • Laboratory tests showed elevated levels of total testosterone (348 ng/dL) and DHEA-S (2,058 microg/dL), and a left adrenal tumor (3 by 4 cm) was detected on abdominal computed tomographic scan.
  • Laparoscopic left adrenalectomy was performed, and the pathologic diagnosis was adrenal adenoma.
  • Bilateral oophorectomy was performed, and an ovarian Sertoli-Leydig cell tumor was diagnosed.
  • CONCLUSION: After extensive review of the literature, we believe that this is the first reported case of a coincidental DHEA-S-secreting adrenal adenoma and a testosterone- secreting ovarian Leydig cell tumor causing signs of virilization.
  • [MeSH-major] Adrenocortical Adenoma / metabolism. Dehydroepiandrosterone Sulfate / metabolism. Hyperandrogenism / diagnosis. Hyperandrogenism / etiology. Leydig Cell Tumor / metabolism. Testosterone / metabolism

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  • (PMID = 19289327.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; 57B09Q7FJR / Dehydroepiandrosterone Sulfate
  • [Number-of-references] 13
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35. Ammoury RF, Heptulla RA, Tatevian N, Elenberg E: Laparoscopic adrenalectomy of an adrenal adenoma with myelolipoma relieves severe hypertension in a 16-year-old patient. Pediatr Nephrol; 2006 Mar;21(3):433-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic adrenalectomy of an adrenal adenoma with myelolipoma relieves severe hypertension in a 16-year-old patient.
  • Adrenal adenoma with myelolipoma is extremely rare in pediatrics.
  • A 16-year-old patient was diagnosed with severe hypertension associated with a right adrenal mass.
  • MRI of the abdomen showed a heterogeneous adrenal mass 4.2x3.3 cm.
  • Laparoscopic resection of the mass was done, and the pathology revealed an adrenal adenoma with myelolipoma.
  • This is a case in which an adrenal adenoma with myelolipoma, a benign and usually asymptomatic tumor, presented as severe hypertension resolving with surgical resection of the tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy. Adrenocortical Adenoma / surgery. Hypertension / etiology. Laparoscopy. Myelolipoma / surgery. Neoplasms, Multiple Primary / surgery


36. Abdullah N, Khawaja K, Hale J, Barrett AM, Cheetham TD: Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. J Pediatr Endocrinol Metab; 2005 Feb;18(2):215-9
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  • [Title] Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy.
  • Investigations revealed primary hyperaldosteronism secondary to an adrenal adenoma (Conn's syndrome).
  • The hypertension resolved following excision of the adrenal tumour.
  • Normokalaemia with potassium >4.0 mmol/l is very unusual in patients with Conn's syndrome and has not been described in childhood before.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / complications. Adrenocortical Adenoma / diagnosis. Hyperaldosteronism / etiology. Hypertension / etiology. Potassium / blood


37. Blanco C, Maqueda E, Rubio JA, Rodriguez A: Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy. J Endocrinol Invest; 2006 Feb;29(2):164-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy.
  • Cushing's syndrome during pregnancy is a rare and difficult to diagnose disorder.
  • We describe the case of a 30-yr-old woman presenting with symptoms and signs of mild hypercortisolism, in which ACTH-independent Cushing's syndrome was diagnosed.
  • An abdominal computed tomography scan confirmed a left adrenal mass.
  • While diagnosis work-up was still in progress, the patient became pregnant and wanted to carry her pregnancy to full-term.
  • Pathologic examination of the gland showed a benign adrenocortical adenoma.
  • The patient developed secondary adrenal insufficiency and was discharged on 20 mg hydrocortisone daily dose.
  • No apparent metyrapone-induced teratogenic effects were observed and there was no clinical or biochemical suppression of adrenocortical function.
  • In conclusion, in adrenal Cushing's syndrome during pregnancy, medical treatment with metyrapone as soon as the diagnosis is made, in combination with laparoscopic surgery during the second trimester, are useful in preventing complications secondary to hypercortisolism and safe both for the mother and infant.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Adrenalectomy. Cushing Syndrome / therapy. Metyrapone / therapeutic use. Pregnancy Complications / therapy


38. Hirai H, Shibata T, Sasaki Y, Fujii H, Kubo S, Suehiro S: Simultaneous surgery for chronic aortic dissection and adrenal adenoma with primary aldosteronism. Gen Thorac Cardiovasc Surg; 2010 May;58(5):235-7; discussion 238
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous surgery for chronic aortic dissection and adrenal adenoma with primary aldosteronism.
  • Magnetic resonance images showed a 1-cm nodule in the left adrenal gland.
  • Graft replacement for aortic dissection under extracorporeal circulation and resection of the left adrenal gland were undertaken simultaneously.
  • [MeSH-major] Adenoma / surgery. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Aneurysm, Dissecting / surgery. Aortic Aneurysm, Thoracic / surgery. Blood Vessel Prosthesis Implantation. Hyperaldosteronism / surgery. Hypertension / surgery
  • [MeSH-minor] Adult. Antihypertensive Agents / therapeutic use. Aortography / methods. Blood Pressure. Chronic Disease. Humans. Magnetic Resonance Imaging. Male. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 20449714.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antihypertensive Agents
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39. Guthoff M, Schnauder G, Kirchhoff K, Kurth R, Horger M, Müssig K: [Normokalaemic primary aldosteronism due to an aldosterone-producing adrenal adenoma--Case 06/2009]. Dtsch Med Wochenschr; 2009 Jul;134(31-32):1582
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  • [Title] [Normokalaemic primary aldosteronism due to an aldosterone-producing adrenal adenoma--Case 06/2009].
  • INVESTIGATIONS: Ultrasound displayed no evidence of renal artery stenosis.
  • Renal function was normal.
  • MRI revealed an adenoma of the right adrenal gland.
  • DIAGNOSIS, TREATMENT AND COURSE: The results were consistent with primary aldosteronism due to an aldosterone-producing adenoma of the adrenal gland.
  • The histological findings confirmed an adenoma of the adrenal gland.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Hyperaldosteronism / etiology
  • [MeSH-minor] Adrenalectomy / methods. Adult. Aldosterone / blood. Aldosterone / secretion. Diagnosis, Differential. Humans. Hypertension / etiology. Laparoscopy. Magnetic Resonance Imaging. Male. Renin / blood

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  • (PMID = 19629922.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
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40. Denzinger S, Burger M, Hartmann A, Hofstaedter F, Wieland WF, Ganzer R: Spontaneous rupture of a benign giant adrenal adenoma. APMIS; 2007 Apr;115(4):381-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous rupture of a benign giant adrenal adenoma.
  • We report on a 50-year-old patient with a giant benign adenoma of the adrenal cortex, which ruptured spontaneously, leading to life-threatening retroperitoneal hemorrhage.
  • Following emergency adrenalectomy with sparing of the ipsilateral kidney, an adenoma of the adrenal cortex with a diameter of 18 cm and a weight of 1400 g was found.
  • A detailed literature search showed this to be the largest benign tumor of the adrenal cortex described so far.
  • We discuss the diagnosis and treatment of this unusual tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis
  • [MeSH-minor] Humans. Middle Aged. Rupture, Spontaneous / diagnosis. Rupture, Spontaneous / pathology. Rupture, Spontaneous / surgery. Treatment Outcome

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  • (PMID = 17504308.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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41. Wolak T, Hazkani I, Friger M, Paran E: [Target organ damage in hyperaldosteronism versus essential hypertension--the Beer Sheba experience]. Harefuah; 2010 Mar;149(3):161-5, 194
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  • OBJECTIVE: To evaluate the rate of target organ damage in PAL patients versus essential hypertension patients (EHT) and to compare the rate of target organ damage in PAL patients who had adrenal adenoma versus patients with no adrenal adenoma.
  • The diagnosis of PAL was performed according to standard protocol.
  • This group of patients was composed of 12 patients with adrenal adenoma and 37 patients with no adrenal adenoma.
  • In the PAL patients with adrenal adenoma versus the group with no adrenal adenoma, a significant higher prevalence of brain involvement was observed.
  • CONCLUSIONS: The diagnosis of PAL is essential in order to provide the appropriate treatment for blood pressure reduction and prevention of target organ damage.
  • [MeSH-major] Hyperaldosteronism / diagnosis
  • [MeSH-minor] Adenoma / complications. Adrenal Gland Neoplasms / complications. Blood Pressure. Diabetes Complications / epidemiology. Humans. Hypertension / etiology. Prevalence

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  • (PMID = 20684167.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
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42. Mac Gregor Gooch AL, Guillermina Velasco Diaz G, Carranza Lira S: [Virilizing adrenal adenoma: a report of a case]. Ginecol Obstet Mex; 2005 May;73(5):261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Virilizing adrenal adenoma: a report of a case].
  • [Transliterated title] Adenoma suprarrenal virilizante: comunicación de un caso.
  • Androgen excess can be due to different entities such as polycystic ovarian syndrome, ovarian tumors or adrenal tumors.
  • It is presented the case of a 26 year-old woman that suffered from amenorrhea, hirsutism, voice deepening, reduction of mammary volume and 10 kg weight loss, without response to different treatments.
  • The CAT scan and nuclear magnetic imaging of adrenal glands showed an oval retroperitoneal image of 7.2 x 6.5 x 8.4 cm at the right adrenal gland.
  • Surgery was performed and the right adrenal gland excised.
  • The histopathologic report indicated a benign cortical adenoma.
  • [MeSH-major] Adenoma / complications. Adrenal Cortex Neoplasms / complications. Virilism / etiology

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  • (PMID = 21966765.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 409J2J96VR / Androstenedione; 57B09Q7FJR / Dehydroepiandrosterone Sulfate
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43. Hari Kumar K, Jha S, Jha R, Modi KD: Conns' syndrome - atypical presentations. Saudi J Kidney Dis Transpl; 2009 Mar;20(2):278-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Both the patients had a characteristic biochemical and imaging profile consistent with primary hyperaldosteronism and responded to surgical resection of adrenal adenoma.
  • [MeSH-major] Hyperaldosteronism / diagnosis
  • [MeSH-minor] Adrenalectomy / methods. Adult. Blood Pressure / physiology. Diagnosis, Differential. Electrocardiography. Follow-Up Studies. Humans. Male. Middle Aged. Mineralocorticoid Receptor Antagonists / therapeutic use. Potassium / blood. Potassium / urine. Potassium Compounds / therapeutic use. Spironolactone / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 19237819.001).
  • [ISSN] 1319-2442
  • [Journal-full-title] Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • [ISO-abbreviation] Saudi J Kidney Dis Transpl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Mineralocorticoid Receptor Antagonists; 0 / Potassium Compounds; 27O7W4T232 / Spironolactone; RWP5GA015D / Potassium
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44. Jeong BC, Park YH, Han DH, Kim HH: Laparoendoscopic single-site and conventional laparoscopic adrenalectomy: a matched case-control study. J Endourol; 2009 Dec;23(12):1957-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: The purpose of this study was to describe our initial clinical experience and assess the feasibility of laparoendoscopic single-site surgery (LESS) in the treatment of benign adrenal adenoma.
  • PATIENTS AND METHODS: Nine patients undergoing LESS adrenalectomy for benign adrenal adenoma were compared with 17 patients undergoing conventional laparoscopic adrenalectomy.
  • CONCLUSIONS: LESS adrenalectomy for benign adrenal adenoma is comparable to the conventional laparoscopic approach with regard to the operative time, blood loss, length of hospital stay, and degree of complication, and has demonstrated more desirable cosmetic outcomes.

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  • (PMID = 19909074.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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45. Agarwal MD, Trerotola SO: Combined adrenal and ovarian venous sampling to localize an androgen producing tumor. Cardiovasc Intervent Radiol; 2010 Dec;33(6):1266-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined adrenal and ovarian venous sampling to localize an androgen producing tumor.
  • A 1-cm adrenal adenoma was noted on computed tomography.
  • Combined adrenal and ovarian venous sampling was performed to localize an androgen producing tumor to the left ovary.
  • [MeSH-minor] Adrenal Glands / blood supply. Adrenocortical Adenoma / radiography. Female. Hirsutism / blood. Hirsutism / etiology. Humans. Hydrocortisone / blood. Middle Aged. Ovary / blood supply. Tomography, X-Ray Computed. Veins

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  • (PMID = 19688363.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; WI4X0X7BPJ / Hydrocortisone
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46. Okosieme OE, Suruliram P, Brade L, Campbell A, Evans LM: Diuretic-induced hypokalaemia in patients with hypertension. Int J Clin Pract; 2006 Dec;60(12):1673-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Investigations revealed primary hyperaldosteronism due to an adrenal adenoma, and normal blood pressure was restored after surgical removal of the tumour.
  • [MeSH-minor] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Female. Humans. Hyperaldosteronism / complications. Middle Aged

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  • (PMID = 16669823.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Diuretics
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47. Sherer DM, Dalloul M, Wagreich A, Sokolovski M, Duan H, Zinn H, Abulafia O: Prenatal sonographic findings of congenital adrenal cortical adenoma. J Ultrasound Med; 2008 Jul;27(7):1091-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal sonographic findings of congenital adrenal cortical adenoma.
  • The differential diagnosis of prenatally diagnosed adrenal masses includes neuroblastoma, adrenal hemorrhage, adrenal and cortical renal cysts, adrenal adenoma and carcinoma, subdiaphragmatic pulmonary sequestration, Beckwith-Wiedemann syndrome, duplication of the renal system, Wilms tumors, congenital mesoblastic nephroma, and mesenteric and enteric duplication cysts.
  • The worldwide annual incidence of childhood adrenal cortical neoplasms ranges between 0.3 and 0.38 per 1 million children younger than 15 years.
  • [MeSH-major] Adrenal Cortex Neoplasms / congenital. Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / congenital. Adrenocortical Adenoma / diagnosis. Ultrasonography, Prenatal / methods
  • [MeSH-minor] Adrenal Cortex / surgery. Adrenal Cortex / ultrasonography. Adult. Diagnosis, Differential. Female. Humans. Imaging, Three-Dimensional / methods. Infant, Newborn. Male. Pregnancy. Radiography, Abdominal / methods. Tomography, X-Ray Computed

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  • (PMID = 18577675.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Bovio S, Reimondo G, Daffara F, Allasino B, Angeli A, Terzolo M: [Subclinical Cushing's syndrome in adrenal incidentalomas]. Recenti Prog Med; 2006 Jan;97(1):6-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Subclinical Cushing's syndrome in adrenal incidentalomas].
  • [Transliterated title] La sindrome di Cushing subclinica nei pazienti con incidentaloma surrenalico.
  • In the heyday of high-tech medicine, the incidental discovery of an adrenal mass is a frequent event owing to the routine use of sophisticated radiological techniques.
  • The potential harm to health associated with incidentally discovered cortical adenoma, the most frequent tumor among adrenal incidentalomas, is unclear at present.
  • Incidentally discovered adrenal adenoma may secrete cortisol autonomously, in a way that is no longer under close control by pituitary feedback, in 5 to 20% of cases.
  • At present, data are insufficient to indicate the superiority of a surgical or nonsurgical approach to manage patients with subclinical hyperfunctioning adrenal cortical adenoma.
  • It is of the utmost importance to establish collaborative prospective studies with clearly defined entry criteria and standardized evaluation protocols and treatment modalities to appraise the natural history and long-term morbidity of clinically inapparent adrenal adenoma and subclinical Cushing's syndrome.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Cushing Syndrome
  • [MeSH-minor] Adrenalectomy. Cardiovascular Diseases / etiology. Clinical Trials as Topic. Cross-Sectional Studies. Follow-Up Studies. Humans. Hydrocortisone / secretion. Hydrocortisone / urine. Incidental Findings. Insulin Resistance / genetics. Multicenter Studies as Topic. Phenotype. Prognosis. Risk Factors. Time Factors

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  • (PMID = 16535924.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
  • [Number-of-references] 87
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49. Roggenland D, Schneider S, Klein HH, Kann PH: [Endosonography -- an additional diagnostic possibility in the differentiation between the two common types of primary hyperaldosteronism]. Med Klin (Munich); 2006 Jan 15;101(1):65-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Endosonographie -- eine zusätzliche diagnostische Möglichkeit bei der Differenzierung der beiden häufigsten Formen des primären Hyperaldosteronismus.
  • The distinction between aldosterone-producing adenoma (APA) and idiopathic adrenal hyperplasia (IHA) may be difficult, but establishing the correct diagnosis is essential because surgery is only effective in patients with adrenal adenoma.
  • CASE REPORT: The case of a 65-year-old man with long-term hypertension due to an APA is reported.
  • Magnetic resonance imaging (MRI) of the adrenal glands revealed no abnormalities.
  • Because of the unusual combination of laboratory findings and radiologic results an endosonographic examination of the adrenal glands was performed which yielded a unilateral adrenal adenoma.
  • With establishing this diagnosis, curative surgery became possible.
  • CONCLUSION: This case demonstrates that in the differential diagnosis of primary aldosteronism, endosonography is more important than previously discussed.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Endosonography. Hyperaldosteronism / ultrasonography
  • [MeSH-minor] Adrenal Hyperplasia, Congenital / diagnosis. Adrenalectomy. Aged. Aldosterone / blood. Aldosterone / secretion. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Posture. Time Factors. Treatment Outcome

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  • (PMID = 16418816.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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50. Mlika M, Farah F, Jarboui S, Abdessalem M, Zaouche A, Jilani SB, Zermani R: A benign cystic mass of the pancreas mimicking a malignant lesion. Pathologica; 2009 Dec;101(6):261-2
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  • [Title] A benign cystic mass of the pancreas mimicking a malignant lesion.
  • The case thus demonstrates a rare association between a cystic form of chronic pancreatitis and adrenal adenoma.
  • We report the case of a 46-year-old patient with no particular past medical history who presented with long lasting symptoms consisting in an abdominal pain and deterioration in general health.
  • Imaging findings (ultrasound, CT-scan, MRI) showed a 3-cm cystic lesion of the tail of the pancreas associated with a 3-cm adrenal mass.
  • Because of the suspicion of a malignant disease, surgical treatment was performed.
  • Pathological findings consisted in fibrotic chronic pancreatitis with canal dilatation and an adrenal adenoma.
  • Final diagnosis must be based on pathological features.
  • [MeSH-minor] Adenoma / complications. Adenoma / pathology. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / pathology. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20387716.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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51. Baba Y, Hokotate H, Nakajo M: Comparison of adrenal vein sampling value between aldosterone producing adrenal adenoma and non-functioning adrenal adenoma: evaluation using receiver operating characteristic analysis. Acta Radiol; 2005 Nov;46(7):750-5
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  • [Title] Comparison of adrenal vein sampling value between aldosterone producing adrenal adenoma and non-functioning adrenal adenoma: evaluation using receiver operating characteristic analysis.
  • PURPOSE: To evaluate adequate criteria for adrenal vein sampling values in patients with aldosterone producing adrenal adenoma (APA), retrospectively.
  • During the same period, 23 patients with non-functioning adrenal adenoma (11 M and 12 F aged 53.56 +/- 11.76 years) were diagnosed based on computed tomography and laboratory data.
  • Bilateral adrenal vein sampling (AVS) for measurement of plasma aldosterone (A) and cortisol (C) was performed, and a receiver operating characteristics (ROC) analysis was conducted to establish the best criteria from the AVS-derived index in patients with APA.
  • The Az values for A (APA side)/A (contralateral side) were 0.8948 and 0.9260 for right and left APA, respectively.
  • CONCLUSION: The A (APA side)/A (contralateral side) value was the best compromise for sensitivity and false-positive rate for lateralization of APA.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Adrenal Glands / blood supply. Aldosterone / blood. Hydrocortisone / blood. Hyperaldosteronism / etiology. ROC Curve

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  • (PMID = 16372697.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; WI4X0X7BPJ / Hydrocortisone
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52. Danilovic DL, Freire DS, Paraíba DB, Brandão Neto RA, Lucon AM, Pereira MA: [Primary aldosteronism caused by aldosteronoma: problems in the etiologic diagnosis]. Arq Bras Endocrinol Metabol; 2007 Apr;51(3):478-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary aldosteronism caused by aldosteronoma: problems in the etiologic diagnosis].
  • We present a case of PA caused by an aldosteronoma associated with a contralateral nonfunctioning adrenal adenoma, which resulted in difficulties in the final diagnosis.
  • We discuss the most appropriated tests to screen, confirm the diagnosis of PA and define the etiology of the disorder, especially the adrenal veins sampling to distinguish the aldosteronoma and idiopathic hyperaldosteronism and to guide successful treatment.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Hyperaldosteronism / diagnosis
  • [MeSH-minor] Aldosterone / blood. Diagnosis, Differential. Female. Humans. Hypertension / complications. Middle Aged. Renin / blood. Tomography, X-Ray Computed

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  • (PMID = 17546249.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
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53. Tan HS, Thai AC, Nga ME, Mukherjee JJ: Development of ipsilateral adrenocortical carcinoma sixteen years after resection of an adrenal tumour causing Cushing's syndrome. Ann Acad Med Singapore; 2005 Apr;34(3):271-4
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  • [Title] Development of ipsilateral adrenocortical carcinoma sixteen years after resection of an adrenal tumour causing Cushing's syndrome.
  • INTRODUCTION: At times, it may be difficult to differentiate early stage, low-grade adrenocortical carcinoma from benign adrenal adenoma.
  • CLINICAL PICTURE: A 53-year-old lady underwent right adrenalectomy for a 4-cm adrenocortical tumour causing Cushing's syndrome.
  • Histology revealed an adrenocortical adenoma.
  • Sixteen years later, she presented with a 14-cm adrenal tumour, again on the right side.
  • Histology confirmed adrenocortical carcinoma.
  • OUTCOME: She died of metastatic disease 17 months later.
  • CONCLUSIONS: This case highlights the importance of long-term, systematic follow-up of patients treated for benign adrenal adenomas, especially if the tumour size exceeds 4 cm.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Carcinoma / pathology. Cushing Syndrome / etiology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adrenocortical Adenoma / pathology. Diagnosis, Differential. Fatal Outcome. Female. Humans. Middle Aged

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  • (PMID = 15902349.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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54. Amoedo ML, Martín ML, Muray S, Craver L, Panadés MJ, Ramos J, Pérez Ruiz L, Fernández E: [Hypokaliemic nephropathy as a form of presentation of Conn syndrome]. Nefrologia; 2006;26(2):274-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hypokaliemic nephropathy as a form of presentation of Conn syndrome].
  • [Transliterated title] Nefropatía hipokaliémica como presentación de un síndrome de Conn.
  • However, chronic hypokalemia can induce chronic renal failure through a characteristic tubulointerstitial damage consisting on vacuolization of epithelial tubular cells and interstitial fibrosis.
  • We present a clinical report of a patient admitted to our hospital with a severe hypokalemia secondary to an aldosterone producing adrenal adenoma that was diagnosed during admission.
  • Besides hypokalemia the patient presented renal failure.
  • Renal biopsy proved characteristic tubulointerstitial damage as described in hypokaliemic nephropathy.
  • In summary, we report a Conn syndrome presenting as a hypokalemic nephropathy.
  • [MeSH-major] Hyperaldosteronism / complications. Hypokalemia / etiology. Kidney Diseases / etiology

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  • (PMID = 16808268.001).
  • [ISSN] 0211-6995
  • [Journal-full-title] Nefrología : publicación oficial de la Sociedad Española Nefrologia
  • [ISO-abbreviation] Nefrologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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55. Lim LC, Tan LH, Rajasoorya C: Unravelling the mystery in a case of persistent ACTH-independent Cushing's syndrome. Ann Acad Med Singapore; 2006 Dec;35(12):892-6
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  • INTRODUCTION: We present a rare variety of adrenocorticotrophic hormone (ACTH)-independent Cushing's syndrome known as primary pigmented nodular adrenocortical disease (PPNAD).
  • CLINICAL PICTURE: The patient initially underwent unilateral adrenalectomy for what was thought to be a left adrenal adenoma.
  • OUTCOME: Partial resolution of symptoms and demonstrable persistent hypercortisolism after surgery prompted further evaluation with findings leading to the diagnosis of Carney complex.
  • A review of the adrenal histology was consistent with PPNAD.
  • The diagnosis may not be simple and straightforward, as illustrated in this patient.
  • [MeSH-major] Cushing Syndrome / diagnosis
  • [MeSH-minor] Adrenal Glands / radiography. Adrenalectomy. Adrenocortical Hyperfunction / physiopathology. Adrenocorticotropic Hormone / metabolism. Adult. Bone Density. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17219002.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
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56. López Martín L, García Cardoso JV, Gómez Muñoz J, González Enguita C: Adrenal myelolipoma. Contribution of a case and bibliographic review. Arch Esp Urol; 2010 Dec;63(10):880-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal myelolipoma. Contribution of a case and bibliographic review.
  • OBJECTIVE: We report the case of adrenal gland myelolipoma.
  • METHODS/RESULTS: The patient was a 29 year old who is diagnosed with an adrenal adenoma during an endocrinology review.
  • The pathological study confirmed the diagnosis of adrenal myelolipoma.
  • [MeSH-major] Adrenal Gland Neoplasms. Myelolipoma

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  • (PMID = 21187573.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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57. Obinata D, Yamaguchi K, Hirano D, Yoshida T, Soma M, Takahashi S: Preoperative management of Cushing's syndrome with metyrapone for severe psychiatric disturbances. Int J Urol; 2008 Apr;15(4):361-2
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  • A 56-year-old woman suffered from severe depression due to Cushing's syndrome with right adrenal adenoma.
  • [MeSH-major] Depressive Disorder / drug therapy. Metyrapone / therapeutic use. Pituitary ACTH Hypersecretion / drug therapy. Steroid 11-beta-Hydroxylase / antagonists & inhibitors
  • [MeSH-minor] Adenoma / complications. Adenoma / surgery. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Female. Humans. Middle Aged

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  • (PMID = 18380829.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] EC 1.14.15.4 / Steroid 11-beta-Hydroxylase; ZS9KD92H6V / Metyrapone
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58. Johnson SP, Bagrosky BM, Mitchell EL, McIntyre RC Jr, Grant NG: CT-guided radiofrequency ablation of an aldosterone-secreting primary adrenal tumor in a surgically unfit patient. J Vasc Interv Radiol; 2008 Jul;19(7):1115-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CT-guided radiofrequency ablation of an aldosterone-secreting primary adrenal tumor in a surgically unfit patient.
  • Because of the speed and efficiency of laparoscopic adrenalectomy, alternative surgical procedures for adrenal adenomas are uncommon.
  • The present report outlines the case of a young patient with an adrenal adenoma causing Conn syndrome who was a poor candidate for surgical treatment.
  • Computed tomography (CT)-guided radiofrequency ablation of the adenoma was performed with a paraspinal approach and injection of dextrose 5% in water.
  • [MeSH-major] Adenoma / surgery. Adrenal Gland Neoplasms / surgery. Aldosterone / secretion. Catheter Ablation. Hyperaldosteronism / etiology. Radiography, Interventional. Tomography, X-Ray Computed

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  • (PMID = 18589330.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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59. Ashizawa N, Takagi M, Seto S, Suzuki S, Yano K: Serum adiponectin and leptin in a patient with Cushing's syndrome before and after adrenalectomy. Intern Med; 2007;46(7):383-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We measured the serum adiponectin and leptin concentrations before and after successful removal of a left adrenal adenoma in a 46-year-old woman with Cushing's syndrome.
  • [MeSH-major] Adenoma / surgery. Adiponectin / blood. Adrenal Gland Neoplasms / surgery. Cushing Syndrome / surgery. Leptin / blood

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  • (PMID = 17409602.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Biomarkers; 0 / Leptin
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60. Sugár I, Vörös A, Diczházi C, Barabás L, Valkó L, Kovács GL, Ondrejka P: [Successfully operated cases of mediastinal and retroperitoneal bronchial cysts]. Magy Seb; 2010 Aug;63(4):168-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the first case a mediastinal cyst caused severe swallowing problems, while in the second a retroperitoneal cyst resembled to an adrenal adenoma.
  • It was only the postoperative histology, which clarified the exact diagnosis of the removed cysts.
  • In most of the cases the final diagnosis is made only after excision with histological examination of the cyst.
  • [MeSH-major] Bronchogenic Cyst / diagnosis. Bronchogenic Cyst / surgery. Mediastinal Cyst / diagnosis. Mediastinal Cyst / surgery
  • [MeSH-minor] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Adult. Deglutition. Diagnosis, Differential. Humans. Male. Retroperitoneal Space / pathology. Retroperitoneal Space / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20724242.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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61. Ong K, Tan KB, Putti TC: Myelolipoma within a non-functional adrenal cortical adenoma. Singapore Med J; 2007 Jul;48(7):e200-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myelolipoma within a non-functional adrenal cortical adenoma.
  • Myelolipoma within an adrenal cortical adenoma is a very rare cause of adrenal incidentaloma, and only nine cases have been reported in the English and Japanese literature.
  • Clinical history, physical examination and laboratory results did not show any evidence to suggest metabolic disorder such as Cushing's syndrome, hyperaldosteronism or catecholamine hypersecretion.
  • The patient underwent a left adrenalectomy, and a histopathological study confirmed the mass to be a non-functional adrenal cortical adenoma containing myelolipoma.
  • To the best of our knowledge, this is the first non-functional adrenal cortical adenoma reported; in the nine cases of myelolipoma within an adrenal cortical adenoma reported previously, all the patients had Cushing's syndrome.
  • The literature on synchronous myelolipoma with adrenal adenoma, and myelolipoma within functional adrenal adenoma, is reviewed.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Myelolipoma / pathology

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  • (PMID = 17609815.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 11
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62. Kato J, Etoh T, Kitamura K, Eto T: Atrial and brain natriuretic peptides as markers of cardiac load and volume retention in primary aldosteronism. Am J Hypertens; 2005 Mar;18(3):354-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We examined 11 patients with PA due to aldosterone-producing adrenal adenoma before and after surgical resection.
  • RESULTS: Plasma levels of ANP and BNP were elevated in the PA patients compared with normotensive control subjects (P < .01), and the elevated ANP and BNP levels were reduced (P < .01) after adenoma resection.
  • CONCLUSION: The present results suggest that the plasma level of BNP is more closely related to cardiac load or volume status than ANP is, in patients with PA due to adrenal adenoma.
  • [MeSH-minor] Adenoma / blood. Adenoma / physiopathology. Adenoma / surgery. Adrenal Gland Neoplasms / blood. Adrenal Gland Neoplasms / physiopathology. Adrenal Gland Neoplasms / surgery. Adult. Biomarkers / blood. Female. Humans. Male. Middle Aged

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  • (PMID = 15797653.001).
  • [ISSN] 0895-7061
  • [Journal-full-title] American journal of hypertension
  • [ISO-abbreviation] Am. J. Hypertens.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 114471-18-0 / Natriuretic Peptide, Brain; 85637-73-6 / Atrial Natriuretic Factor
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63. Ridho FE, Adam FM, Adam JM: Adrenal incidentaloma. Acta Med Indones; 2009 Apr;41(2):87-93
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  • [Title] Adrenal incidentaloma.
  • Adrenal Incidentaloma is an adrenal tumor, which is unidentified before the imaging procedures conducted for an abnormality which is initially unforeseen as an adrenal disease.
  • Symptoms and/or clinical signs of adrenal tumor do not have to be present prior to a diagnosis.
  • Adrenal Incidentaloma can be divided into non-hypersecreting adrenal adenoma, hypersecreting tumor, primary adrenal carcinoma, other adrenal mass, and metastases.
  • The majority of adrenal tumor is non-hypersecreting adrenal adenoma, but it is always considered as hypersecreting tumor until proven otherwise.
  • Some conditions that can be found due to hormonal activity of adrenal incidentaloma is subclinical Cushing's syndrome, pheochromocytoma, aldosteronoma (Conn's disease), and several tumors which secrete androgen and sex hormone.
  • Diagnostic approach of adrenal incidentaloma is focused on two main problems, which are, whether the lesion is hormonally active even though lacking characteristic clinical signs, and whether the lesion is benign or malignant; thus it needs hormonal and radiologic evaluation, even a fine needle biopsy.
  • The management for adrenal incidentaloma includes surgical removal for hormonally active adrenal tumors, or inactive tumors with size less than 4 cm.
  • [MeSH-major] Adrenal Gland Neoplasms. Aldosterone / blood. Catecholamines / urine. Incidental Findings. Renin / blood
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Indonesia / epidemiology. Morbidity / trends

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  • (PMID = 19390128.001).
  • [ISSN] 0125-9326
  • [Journal-full-title] Acta medica Indonesiana
  • [ISO-abbreviation] Acta Med Indones
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Indonesia
  • [Chemical-registry-number] 0 / Catecholamines; 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
  • [Number-of-references] 38
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64. Yip L, Tublin ME, Falcone JA, Nordman CR, Stang MT, Ogilvie JB, Carty SE, Yim JH: The adrenal mass: correlation of histopathology with imaging. Ann Surg Oncol; 2010 Mar;17(3):846-52
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  • [Title] The adrenal mass: correlation of histopathology with imaging.
  • BACKGROUND: Computed tomography (CT) and magnetic resonance (MR) imaging can help diagnose benign adrenal adenomas, but prior studies rely on nonoperative follow-up as proof of a lesion's benign nature.
  • Imaging results were considered to signify benign adrenal adenoma if one or more of the following was present: Hounsfield units <10 on unenhanced CT, contrast-enhanced CT quantifying absolute contrast washout of >60% or relative contrast washout of >40%, or MR with chemical-shift imaging demonstrating loss of signal intensity on out-of-phase images.
  • RESULTS: The sensitivity and specificity of preoperative imaging in predicting benign adrenal adenoma were 57 and 94%, respectively.
  • Histopathology confirmed that all 66 adrenal masses with imaging characteristics suggesting benign adenoma were indeed benign lesions and included 61 benign adrenal adenomas and 5 benign nonadenomatous lesions (3 myelolipomas, 1 composite myelolipoma/adenoma, and 1 ganglioliponeuroma).
  • Malignant adrenal lesions were diagnosed in 17/130 (13%) masses: 8 metastases, 7 adrenal cortical carcinomas, 1 epithelioid angiosarcoma, and 1 ganglioneuroblastoma.
  • CONCLUSION: CT or MR characteristics predicted the presence of benign lesions with 100% specificity.
  • Every adrenal malignancy had CT or MR results that were inconsistent with benign adenoma (100% sensitivity).
  • To exclude malignancy, adrenal masses with non-benign imaging characteristics should be resected.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radiography. Adrenocortical Adenoma / pathology. Adrenocortical Adenoma / radiography. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 19960266.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Kawamata A, Iihara M, Okamoto T, Obara T: Bone mineral density before and after surgical cure of Cushing's syndrome due to adrenocortical adenoma: prospective study. World J Surg; 2008 May;32(5):890-6
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  • [Title] Bone mineral density before and after surgical cure of Cushing's syndrome due to adrenocortical adenoma: prospective study.
  • The aim of the present study was to assess the chronologic effect of surgical cure on bone mineral density (BMD) in patients with Cushing's syndrome due to adrenal adenoma.
  • Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing's syndrome due to adrenal adenoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / surgery. Bone Density / physiology. Cushing Syndrome / surgery

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  • (PMID = 18210182.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Calò LA, Pagnin E, Davis PA, Armanini D, Mormino P, Rossi GP, Pessina AC: Oxidative stress-related proteins in a Conn's adenoma tissue. Relevance for aldosterone's prooxidative and proinflammatory activity. J Endocrinol Invest; 2010 Jan;33(1):48-53

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  • [Title] Oxidative stress-related proteins in a Conn's adenoma tissue. Relevance for aldosterone's prooxidative and proinflammatory activity.
  • MATERIALS AND METHODS: We assessed gene and protein expression of p22phox (RT-PCR and Western blot), NAD(P)H oxidase subunit essential for superoxide production and gene expression of transforming growth fator (TGF) beta, plasminogen activator inhibitor (PAI)-1, and heme oxygenase (HO)-1, effectors of OxSt (RT-PCR), in a Conn's adenoma, removed from a patient with primary hyperaldosteronism.
  • The normal adrenal tissue adjacent to the adenoma was used as control.
  • RESULTS: p22phox gene and protein expression were higher (31% and 53%, respectively) in the adrenal adenoma.
  • TGFbeta, PAI-1, and HO-1 gene expression were also higher (25%, 129%, and 25%, respectively) in the adrenal adenoma while AT1R gene expression was similar (8%).
  • The expression of MR in the adenoma was documented.
  • The presence of MR expression in the adenoma may link the hormone with the adenoma growth.
  • [MeSH-major] Adrenal Cortex Neoplasms / physiopathology. Adrenocortical Adenoma / physiopathology. Aldosterone / physiology. Oxidative Stress / drug effects
  • [MeSH-minor] Adrenal Glands / metabolism. Adult. Female. Gene Expression. Heme Oxygenase-1 / genetics. Humans. Hyperaldosteronism / surgery. NADPH Oxidase / genetics. Plasminogen Activator Inhibitor 1 / genetics. Receptor, Angiotensin, Type 1 / genetics. Receptors, Mineralocorticoid / genetics. Transforming Growth Factor beta / genetics

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  • (PMID = 19625761.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Plasminogen Activator Inhibitor 1; 0 / Receptor, Angiotensin, Type 1; 0 / Receptors, Mineralocorticoid; 0 / Transforming Growth Factor beta; 4964P6T9RB / Aldosterone; EC 1.14.99.3 / Heme Oxygenase-1; EC 1.6.3.1 / CYBA protein, human; EC 1.6.3.1 / NADPH Oxidase
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67. Trésallet C, Salepçioglu H, Godiris-Petit G, Hoang C, Girerd X, Menegaux F: Clinical outcome after laparoscopic adrenalectomy for primary hyperaldosteronism: the role of pathology. Surgery; 2010 Jul;148(1):129-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pre-operative assessment rarely differentiates adrenal adenoma from hyperplasia.
  • This study aimed to evaluate the results of LUA for PHA according to pathologic findings when an adrenal mass was identified unequivocally on a CT scan.
  • Thirty-six patients (63%) had an adrenal adenoma and 21 (37%) a hyperplasia.
  • Predictive factors for a cure were: gender, age, BMI, duration of hypertension, number of pre-operative AMs, pre-operative arterial systolic blood pressure, creatinin and plasma renin activity.
  • Pre-operative diagnosis of adenoma or hyperplasia is not mandatory but it is important to warn patients that hypertension can persist after adrenalectomy, especially in case of adrenal hyperplasia, although this hypertension is easier to control.

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • [CommentIn] Surgery. 2011 Jun;149(6):852 [21208633.001]
  • (PMID = 20083287.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
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68. Petramala L, Battisti P, Lauri G, Palleschi L, Cotesta D, Iorio M, De Toma G, Sciomer S, Letizia C: Cushing's syndrome patient who exhibited congestive heart failure. J Endocrinol Invest; 2007 Jun;30(6):525-8
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  • In this article we report the case of a 28-yr-old woman with CS secondary to adrenal adenoma who exhibited congestive heart failure as an initial symptom.
  • An abdominal magnetic resonance imaging scan showed a 7-cm right adrenal mass.
  • A laparoscopic right adrenalectomy was performed and pathological examination of the gland showed a benign adrenocortical adenoma.
  • In conclusion we report the case of heart failure as the main clinical symptom in CS secondary to adrenal adenoma.
  • [MeSH-major] Adrenocortical Adenoma / complications. Cushing Syndrome. Heart Failure / etiology


69. Hood S, Cannon J, Foo R, Brown M: Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. Clin Med (Lond); 2005 Jan-Feb;5(1):55-60
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  • The primary outcome measure was to discover the proportion of patients with plasma aldosterone > or = 400 pmol/l and ARR > or = 800 and either an adrenal adenoma on computed tomography scan or a systolic blood pressure response to spironolactone > or = 20 mmHg.
  • Only one patient had an adenoma, and only 16 (1.8%) had both a plasma aldosterone > or = 400 pmol/l and ARR > or = 800.
  • We concluded that adrenal adenomas are an uncommon cause of hypertension.
  • A plasma aldosterone >400 pmol/l together with renin activity < or = 0.5 pmol/ml/h should trigger further investigations for an adrenal adenoma.
  • [MeSH-minor] Adenoma / complications. Adrenal Gland Neoplasms / complications. Aged. Blood Pressure / drug effects. Female. Humans. Hypertension / etiology. Male. Middle Aged. Mineralocorticoid Receptor Antagonists / pharmacology. Spironolactone / pharmacology

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  • (PMID = 15745200.001).
  • [ISSN] 1470-2118
  • [Journal-full-title] Clinical medicine (London, England)
  • [ISO-abbreviation] Clin Med (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Mineralocorticoid Receptor Antagonists; 27O7W4T232 / Spironolactone; 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
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70. Adlan MA, Bondugulapati LN, Premawardhana LD: Glucose intolerance and diabetes mellitus in endocrine disorders - two case reports and a review. Curr Diabetes Rev; 2010 Sep;6(5):266-73
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  • We describe two subjects who were cured of their poorly controlled diabetes mellitus following surgical removal of a phaeochromocytoma and a cortisol secreting adrenal adenoma and review the mechanisms underlying glucose intolerance in endocrine disorders.
  • [MeSH-major] Diabetes Mellitus / etiology. Endocrine System Diseases / complications. Glucose Intolerance / etiology
  • [MeSH-minor] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / physiopathology. Adrenal Gland Neoplasms / surgery. Diabetes Complications / metabolism. Diabetes Complications / physiopathology. Female. Humans. Hypertension / complications. Hypertension / etiology. Hypertension / metabolism. Hypertension / surgery. Male. Middle Aged. Pheochromocytoma / complications. Pheochromocytoma / diagnosis. Pheochromocytoma / physiopathology. Pheochromocytoma / surgery. Radiography, Abdominal

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  • (PMID = 20594162.001).
  • [ISSN] 1875-6417
  • [Journal-full-title] Current diabetes reviews
  • [ISO-abbreviation] Curr Diabetes Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United Arab Emirates
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71. Tanaka K, Morishima Y, Ishii Y, Sakamoto T, Suzuki H, Otsuka F, Hizawa N: [Sarcoidosis presenting after successful treatment for Cushing syndrome]. Nihon Kokyuki Gakkai Zasshi; 2009 Jun;47(6):501-6
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  • She had had a history of Cushing syndrome due to right adrenal adenoma, which was successfully treated by unilateral adrenalectomy two years before her admission to our department; however, the chest radiographic abnormalities and the skin lesions were not apparent at that time.
  • Skin biopsy specimens demonstrated noncaseating epithelioid cell granuloma, which was consistent with the diagnosis of sarcoidosis.
  • An elevated angiotensin-converting enzyme level and increased accumulation of gallium-67 citrate in the pulmonary parenchyma and hilar lymph nodes also supported the diagnosis.
  • We should be aware of the possibility of the condition that steroid-responsive immune diseases such as sarcoidosis might be unmasked and develop after successful treatment for Cushing syndrome.

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  • (PMID = 19601527.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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72. Pai SG, Shivashankara KN, Pandit V, Sheshadri S: Symptomatic hypocalcemia in primary hyperaldosteronism: a case report. J Korean Med Sci; 2009 Dec;24(6):1220-3
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  • But its effects on calcium metabolism, parathyroid metabolism and renal handling of calcium are less well described.
  • We hereby report a case of primary hyperaldosteronism due to adrenal adenoma (Conn's syndrome) who presented with a myriad of clinical features including symptomatic hypocalcemia, significant weight loss along with uncontrolled hypertension for a prolonged period before eventually detected to have primary hyperaldosteronism.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Hyperaldosteronism. Hypocalcemia / etiology

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  • [Cites] Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2023-6 [15475529.001]
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  • (PMID = 19949688.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2775880
  • [Keywords] NOTNLM ; Hypocalcemia / Primary Aldosteronism / Weight Loss
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73. Schaefer S, Meyer S, Brueck CC, Weber M, Luedecke D, Wagner HJ, Kann PH: Sarcoidosis following Cushing's syndrome: A report of two cases and review of the literature. Exp Clin Endocrinol Diabetes; 2010 Mar;118(3):147-50
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  • In rare cases, the treatment of Cushing's syndrome may result in unmasking or aggravation of diseases responsive to glucocorticoid medication.
  • A 32 year-old female showed cutaneous sarcoidosis, arthralgia, mediastinal lymphadenopathy and elevation of angiotensin-converting enzyme and interleukin 2-receptor concentrations after traumatic adrenal bleeding, which ceased formerly undiagnosed hypercortisolism caused by an adrenal adenoma.
  • Skin affections were present and suggestive for the diagnosis in all reported cases.
  • As some cases are probably missed when skin affections are lacking, a more frequent evaluation of patients after Cushing's syndrome for the possible diagnosis of sarcoidosis might be necessary.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / surgery. Adenoma / surgery. Cushing Syndrome / surgery. Sarcoidosis / etiology. Skin Diseases / etiology
  • [MeSH-minor] Adult. Arthralgia / diagnosis. Arthralgia / etiology. Female. Humans. Lymphatic Diseases / diagnosis. Lymphatic Diseases / etiology. Male. Mediastinal Diseases / diagnosis. Mediastinal Diseases / etiology. Peptidyl-Dipeptidase A / analysis. Receptors, Interleukin-2 / analysis

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  • [Copyright] J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart * New York.
  • (PMID = 20162506.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Interleukin-2; EC 3.4.15.1 / Peptidyl-Dipeptidase A
  • [Number-of-references] 13
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74. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • [Title] Radiological localizing techniques in adrenal tumors.
  • The characterisation of adrenal lesions is a common radiological dilemma.
  • Incidental adrenal lesions are commonly detected with computed tomography (CT), and lesion characterisation is critical.
  • The prevalence of incidental adrenal lesions has been reported to be 2.3% at autopsy and 0.5-2% with abdominal CT.
  • Although the majority of adrenal lesions are benign, in patients with an extra-adrenal primary cancer the probability of an adrenal mass being a metastasis is 52%.
  • Unfortunately, there may be significant overlap between the imaging appearances of benign lesions such as lipid-poor adenomas and malignant lesions, particularly metastases and small adrenal carcinomas.
  • This review highlights recent advances in radiological imaging of adrenal lesions and we discuss the relative merits of CT and magnetic resonance imaging to aid the identification of benign and malignant adrenal lesions and their roles, in combination with biochemical and clinical data, in recognizing common pathologies such as adrenal adenoma, phaeochromocytoma, carcinoma and metastases.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Incidental Findings. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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75. Park BK, Kim B, Ko K, Jeong SY, Kwon GY: Adrenal masses falsely diagnosed as adenomas on unenhanced and delayed contrast-enhanced computed tomography: pathological correlation. Eur Radiol; 2006 Mar;16(3):642-7
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  • [Title] Adrenal masses falsely diagnosed as adenomas on unenhanced and delayed contrast-enhanced computed tomography: pathological correlation.
  • OBJECTIVES: To assess the accuracy of CT for the diagnosis of histologically confirmed adrenal adenoma and nonadenoma using CT numbers.
  • MATERIALS AND METHODS: Our study included 91 adrenal masses in 83 patients; histopathological diagnoses were 45 adenomas, 31 pheochromocytomas, 6 hyperplasias, 4 metastasis, and 5 miscellaneous lesions.
  • RESULTS: Sensitivity, specificity, and accuracy for adenoma were 40% (18/45), 91% (42/46), and 66% (60/91) with unenhanced CT, and 96% (24/25), 61% (11/18), and 81% (35/43) with DCE CT.
  • Adrenal masses falsely diagnosed as adenoma on unenhanced CT included three hyperplasias and one endothelial cyst, and those falsely diagnosed as adenoma on DCE CT were five pheochromocytomas, one oncocytic cortical tumor, and one primary pigmented nodular adrenocortical dysplasia.
  • Twenty-five lipid-poor adenomas were falsely diagnosed as nonadenomas on unenhanced CT and one degenerated adenoma both on unenhanced CT and on DCE CT.
  • CONCLUSION: Diagnosing adenoma merely on CT numbers can lead to misdiagnosis.
  • [MeSH-major] Adenoma / radiography. Adrenal Gland Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Analysis of Variance. Contrast Media. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Hyperplasia. Male. Middle Aged. Neoplasm Metastasis. Pheochromocytoma / pathology. Pheochromocytoma / radiography. Sensitivity and Specificity

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  • [ErratumIn] Eur Radiol. 2006 Mar;16(3):768
  • (PMID = 16215735.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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76. Terhune KP, Jagasia S, Blevins LS Jr, Phay JE: Diagnostic and therapeutic dilemmas of hypercortisolemia during pregnancy: a case report. Am Surg; 2009 Mar;75(3):232-4
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  • When they do, it is generally the result of the presence of an adrenal adenoma.
  • We present the case of a 35-year-old woman who was noted to have an adrenal mass before pregnancy, but then during evaluation became pregnant.
  • [MeSH-major] Adenoma / surgery. Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Cushing Syndrome / surgery. Pregnancy Complications / surgery


77. Mariniello B, Ronconi V, Rilli S, Bernante P, Boscaro M, Mantero F, Giacchetti G: Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Eur J Endocrinol; 2006 Sep;155(3):435-41
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  • DESIGN AND METHODS: We have performed a case-control study and studied omental adipose tissue from a total of 24 subjects (eight obese subjects, ten patients with Cushing's syndrome due to adrenal adenoma, and six normal weight controls).

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  • (PMID = 16914598.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Neoplasm; EC 1.1.1.146 / 11-beta-Hydroxysteroid Dehydrogenase Type 1
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78. Lu HS, Gan MF, Chen HS, Huang SQ: Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. J Zhejiang Univ Sci B; 2008 Jun;9(6):500-5
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  • [Title] Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome.
  • The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare, for both tumors present usually as separate entities.
  • To the best of our knowledge, the case we reported here is the first one of myxoid adrenal cortical adenoma associated with myelolipoma reported.
  • Clinical history and laboratory results suggest a metabolic disorder as Conn's syndrome.
  • The patient underwent a left adrenalectomy, and a histopathological study confirmed the mass to be a myxoid adrenal cortical adenoma containing myelolipoma.
  • In the present case report, we also discuss the etiology of simultaneous myelolipoma and adrenal adenoma associated with Conn's syndrome, and the methods of the diagnosis and differential diagnosis.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Hyperaldosteronism / complications. Myelolipoma / complications. Neoplasms, Multiple Primary / complications

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  • (PMID = 18543405.001).
  • [ISSN] 1673-1581
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Synaptophysin; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2408705
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79. Bocca G, Voorhoeve PG, de Delemarre-van Wall HA: [Cushing's syndrome in children]. Ned Tijdschr Geneeskd; 2006 Oct 28;150(43):2345-9
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  • [Transliterated title] Het syndroom van Cushing bij kinderen.
  • In addition, the first showed a decrease in linear growth and weight gain; a pituitary adenoma was found, which was surgically excised.
  • The second girl was examined because of a male body-hair pattern and weight increase.
  • She had an adrenal adenoma, visible on MRI, which was excised during laparoscopy.
  • Cushing's syndrome is a rare disease in childhood.
  • Arriving at an aetiological diagnosis may be difficult and is based on the performance and interpretation of endocrinologic function and laboratory tests such as determination of the cortisol level in blood, saliva and urine, a dexamethasone-suppression test, and a corticotropin assay in blood drawn from the cerebral cavernous sinuses.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / diagnosis. Adenoma / diagnosis. Cushing Syndrome / diagnosis. Hydrocortisone / blood
  • [MeSH-minor] Adolescent. Dexamethasone. Diagnosis, Differential. Female. Growth. Humans. Magnetic Resonance Imaging. Treatment Outcome. Weight Gain

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  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Mar 3;151(9):560; author reply 560-1 [17375397.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2006 Oct 28;150(43):2365-9 [17100127.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2006 Oct 28;150(43):2390-3 [17100132.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2006 Oct 28;150(43):2359-64 [17100126.001]
  • (PMID = 17100122.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; Comment; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 7S5I7G3JQL / Dexamethasone; WI4X0X7BPJ / Hydrocortisone
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80. Hachem S, Khauli RB, Salti I: Surgical adrenal diseases. J Med Liban; 2005 Apr-Jun;53(2):114-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical adrenal diseases.
  • There are four adrenal disorders in which surgery is the treatment of choice: pheochromocytoma, Cushing's syndrome due to ACTH-independent adrenal disease (adenoma, carcinoma or autonomous hyperplasia), primary aldosteronism due to an adrenal adenoma and some adrenal non-functional "incidentilomas".
  • Definitive diagnosis by accurate biochemical assessment of the functional status of the adrenal lesion.
  • A small proportion of adrenal lesions requiring surgery are bilateral and in such situations, special intra- and postoperative care should take into consideration the need for appropriate gluco-corticoid and mineralo-corticoid replacement.
  • The advent of laparoscopic surgery has served to reduce the postoperative morbidity of adrenal surgery and is becoming increasingly the procedure of choice except for large lesions (> 8 cm in diameter).
  • [MeSH-major] Adrenal Gland Diseases / surgery

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  • (PMID = 16604998.001).
  • [ISSN] 0023-9852
  • [Journal-full-title] Le Journal médical libanais. The Lebanese medical journal
  • [ISO-abbreviation] J Med Liban
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Lebanon
  • [Number-of-references] 26
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81. Bagwan IN, Cook G, Mudan S, Wotherspoon A: Unusual presentation of metastatic adenocarcinoma. World J Surg Oncol; 2007;5:116
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  • BACKGROUND: The most common tumours of the adrenal gland are adenoma, pheochromocytoma, adrenocortical carcinoma, and metastases.
  • Although the imaging features of these tumours are established, the imaging characteristics of uncommon adrenal masses are less well known.
  • In patients with extradrenal tumour, incidental discovery of an adrenal mass necessitates excluding the possibility of metastatic malignancy.
  • Sixteen months later on staging CT scan a 2 x 2 cm adrenal mass was detected, which increased in size over a period of time to 3 x 3 cm in size.
  • Adrenalectomy was performed and histological examination revealed metastatic adenocarcinoma within an adrenal adenoma.
  • CONCLUSION: The present case highlights the unusual behaviour of an oesophageal adenocarcinoma causing metastasis to an adrenocortical adenoma.
  • [MeSH-major] Adenocarcinoma / secondary. Adrenal Gland Neoplasms / secondary. Esophageal Neoplasms / pathology

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  • (PMID = 17949483.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2100056
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82. Inaba H, Suzuki S, Shigematsu S, Shinomiya K, Ohfusa H, Shimojo Y, Uehara T, Hashizume K: Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency. Intern Med; 2009;48(8):601-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency.
  • Five years earlier, he underwent simultaneous surgeries for an adrenal adenoma, a benign Leydig cell tumor (LCT), and a malignant lymphoma.
  • Based on the laboratory results, he was diagnosed as congenital adrenal hyperplasia (CAH) due to nonclassical 21-hydroxylase deficiency (21-OHD).
  • On immunohistochemistry analysis using the antibody against adrenal-specific 11beta-hydroxylase antibody, the LCT showed both properties as a testicular cell and as an adrenal cell.
  • [MeSH-major] Adrenal Hyperplasia, Congenital / complications. Adrenal Hyperplasia, Congenital / diagnosis. Leydig Cell Tumor / etiology. Lymphoma / etiology. Testicular Neoplasms / etiology
  • [MeSH-minor] Adrenal Gland Neoplasms / etiology. Adrenal Gland Neoplasms / surgery. Adrenocortical Adenoma / etiology. Adrenocortical Adenoma / surgery. Humans. Hypoglycemia / diagnosis. Hypoglycemia / etiology. Male. Middle Aged

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  • (PMID = 19367056.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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83. Reynolds RM, Shakerdi LA, Sandhu K, Wallace AM, Wood PJ, Walker BR: The utility of three different methods for measuring urinary 18-hydroxycortisol in the differential diagnosis of suspected primary hyperaldosteronism. Eur J Endocrinol; 2005 Jun;152(6):903-7
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  • [Title] The utility of three different methods for measuring urinary 18-hydroxycortisol in the differential diagnosis of suspected primary hyperaldosteronism.
  • OBJECTIVE: Urine 18-hydroxycortisol (18-OHF) measurements are claimed to discriminate between primary hyperaldosteronism due to Conn's syndrome/adrenal adenoma or idiopathic bilateral adrenal hyperplasia (BAH), and also to identify cases of glucocorticoid-suppressible hyperaldosteronism (GSH).
  • METHODS: Urine samples from patients with primary hyperaldosteronism due to either adenoma (n = 6), BAH (n = 6), GSH (n = 9), or essential hypertension (n = 38) were analysed without knowledge of the diagnosis using three different methods in different laboratories.
  • Discrimination between adenoma and BAH patients was best for the DELFIA method, with no overlap between results for these two groups.
  • CONCLUSION: Measurement of urine 18-OHF may be a useful additional test in the differential diagnosis of primary hyperaldosteronism.

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  • (PMID = 15941931.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 81705-06-8 / 18-hydroxycortisol; WI4X0X7BPJ / Hydrocortisone
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84. Pereira JM, Sirlin CB, Pinto PS, Casola G: CT and MR imaging of extrahepatic fatty masses of the abdomen and pelvis: techniques, diagnosis, differential diagnosis, and pitfalls. Radiographics; 2005 Jan-Feb;25(1):69-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CT and MR imaging of extrahepatic fatty masses of the abdomen and pelvis: techniques, diagnosis, differential diagnosis, and pitfalls.
  • The differential diagnosis of extrahepatic abdominopelvic masses is wide.
  • Demonstration of fat within a lesion at noninvasive imaging is an important clue for narrowing the differential diagnosis.
  • Lesions with predominantly microscopic fat include adrenal adenoma and some teratomas.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adenoma / diagnosis. Angiomyolipoma / diagnosis. Diagnosis, Differential. Humans. Teratoma / diagnosis

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  • [Copyright] (c) RSNA, 2005.
  • (PMID = 15653588.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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85. Song JH, Lee KH, Kim SD, Cho BS: Long-term Follow up of Congenital Adrenal Hyperplasia Patients with Hyponatremia. Electrolyte Blood Press; 2007 Dec;5(2):140-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term Follow up of Congenital Adrenal Hyperplasia Patients with Hyponatremia.
  • Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency is an autosomal recessive disease, which leads to cortisol and aldosterone deficiency and hyperandrogenism.
  • Typical medical treatment includes oral glucocorticoid and mineralocorticoid administration to suppress adrenal androgens and to compensate for adrenal steroid deficiencies.
  • Among these patients, four cases of CAH patients showing the presence of hyponatremia as an initial electrolyte disorder were found with adrenal adenoma.
  • Hypersecretion of adrenocorticotrophic hormone and chronic poor compliance to therapy appears to be associated with the development of the adrenal tumor.
  • Two cases were managed with adrenalectomy because of increasing adrenal tumor size and virilization.
  • Therefore, it is important that patients with CAH maintain steroid medication to avoid the appearance of adrenal tumor.

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  • (PMID = 24459514.001).
  • [ISSN] 1738-5997
  • [Journal-full-title] Electrolyte & blood pressure : E & BP
  • [ISO-abbreviation] Electrolyte Blood Press
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3894515
  • [Keywords] NOTNLM ; 21-hydroxylase deficiency / Adrenal tumor / Congenital adrenal hyperplasia / Hyponatremia
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86. Beko G, Varga I, Glaz E, Sereg M, Feldman K, Toth M, Racz K, Patocs A: Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods. Clin Chim Acta; 2010 Mar;411(5-6):364-7
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  • [Title] Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods.
  • METHODS: The study involved 126 consecutive patients referred for evaluation because of symptoms of Cushing's syndrome, obesity, or the presence of incidentally discovered adrenal adenoma.
  • CONCLUSION: MSC measurement is useful for the diagnosis of overt hypercortisolism but the cutoff value is highly dependent on the method used.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Cushing Syndrome / diagnosis. Hydrocortisone / blood. Obesity / diagnosis. Saliva / chemistry

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  • [Copyright] Copyright 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19968981.001).
  • [ISSN] 1873-3492
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; WI4X0X7BPJ / Hydrocortisone
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87. Chen W, Chen GY, Tsai SJ, Wang PW, Sheu HM, Shen YS, Chen FF: Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia. Dermatology; 2005;210(1):49-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hyperandrogenism with hyperandrogenemia should be considered in those with severe acne of sudden onset or conspicuous male-pattern baldness with hairline recession, although the majority of female patients with acne or androgenetic alopecia possess no endocrine disorder.
  • The first one presenting vertical alopecia had an elevated level of serum dehydroepiandrosterone sulfate (>800 microg/dl) and was suspected to be a case of late-onset, non-classical adrenal hyperplasia.
  • The second case with mild acne had a soaring serum level of total testosterone >9,000 ng/dl derived from an androgen-secreting adrenal adenoma overexpressing steroidogenic acute regulatory protein, P450 side-chain cleavage enzyme and aromatase.
  • The possibility of adrenal tumor should be explored in patients with escalated circulating testosterone.
  • [MeSH-major] Acne Vulgaris / complications. Adrenal Gland Neoplasms / diagnosis. Alopecia / complications. Hyperandrogenism / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 15604546.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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88. Kazama I, Komatsu Y, Ohiwa T, Sanayama K, Nagata M: Delayed adrenal insufficiency long after unilateral adrenalectomy: prolonged glucocorticoid therapy reduced reserved secretory capacity of cortisol. Int J Urol; 2005 Jun;12(6):574-7
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  • [Title] Delayed adrenal insufficiency long after unilateral adrenalectomy: prolonged glucocorticoid therapy reduced reserved secretory capacity of cortisol.
  • A 51-year-old woman with Cushing's syndrome underwent unilateral adrenalectomy for left adrenal adenoma.
  • These clinical features together with a low response in the rapid adrenocorticotropic hormone test led to the diagnosis of acute adrenal insufficiency.
  • Relatively low serum adrenocorticotropic hormone levels in the face of increased demand for cortisol during adrenal crisis suggested a disordered hypothalamic-pituitary function, indicating secondary adrenal insufficiency.
  • This patient demonstrated the etiology of acute adrenal insufficiency long after unilateral adrenalectomy in association with subsequent glucocorticoid therapy.
  • A reduction in the reserved secretory capacity of cortisol after prolonged prednisolone treatment was considered to have induced secondary adrenal insufficiency, even after 4 years of total withdrawal from prednisolone.
  • [MeSH-major] Adrenal Insufficiency / etiology. Adrenalectomy / adverse effects. Cushing Syndrome / surgery. Glucocorticoids / adverse effects. Hydrocortisone / secretion. Prednisolone / adverse effects
  • [MeSH-minor] Acute Disease. Female. Humans. Middle Aged. Time Factors

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  • (PMID = 15985081.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Glucocorticoids; 9PHQ9Y1OLM / Prednisolone; WI4X0X7BPJ / Hydrocortisone
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89. Lazúrová I, Dudásová D, Wagnerová H, Dravecká I, Petrásová D: Adrenal incidentalomas and the metabolic syndrome--are there any differences between adenoma and hyperplasia? Neoplasma; 2006;53(4):324-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal incidentalomas and the metabolic syndrome--are there any differences between adenoma and hyperplasia?
  • Authors evaluated the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+/-15 years.
  • 15 patients had adrenal adenoma determined by CT or MR scan and 10 had unilateral or bilateral hyperplasia.
  • Patients with adrenal adenomas had mildly but significantly higher body mass index (BMI, p<0.05) and insulin resistance calculated as HOMA IR (p<0.05) and FIRI (p<0.05) and significantly higher values of serum ferritin (p<0.01).
  • Plasma cortisol values were slightly but not significantly higher in the group with adrenal adenomas.
  • Authors conclude that adrenal adenomas are probably more related to the metabolic syndrome than adrenal hyperplasia.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Adrenal Glands / pathology. Metabolic Syndrome X / diagnosis

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  • (PMID = 16830060.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
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90. Chevalier N, Carrier P, Piche M, Chevallier A, Wagner K, Tardy V, Benchimol D, Fénichel P: Adrenocortical incidentaloma with uncertain prognosis associated with an inadequately treated congenital adrenal hyperplasia. Ann Endocrinol (Paris); 2010 Feb;71(1):56-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenocortical incidentaloma with uncertain prognosis associated with an inadequately treated congenital adrenal hyperplasia.
  • Large adrenal tumors are rarely associated with adrenal enzymatic deficiency, except in 11-ss-hydroxylase insufficiency.
  • We report here the case of a patient with a congenital 21-hydroxylase deficiency (compound heterozygote for two severe mutations in the CYP21A2 gene) untreated for 20 years.
  • His evaluation at 36 years of age showed a four-centimeter mass in the left adrenal gland, with most characteristics suggestive of malignancy (CT and positron emission tomography [PET] scan).
  • We performed a surgical resection that established the diagnosis of adrenocortical tumor of uncertain prognosis (Weiss's score: 3).
  • Even though malignant tumors are unusual in adrenal deficiency, our observation shows the need for a replacement therapy during adulthood, with a regular CT scan follow up in order to diagnose early isolated adrenal adenoma and remove it in case of malignancy suspicion.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenal Hyperplasia, Congenital / complications
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adrenal Glands / pathology. Adrenal Glands / radionuclide imaging. Adrenalectomy. Adult. Cushing Syndrome / etiology. Heterozygote. Humans. Male. Positron-Emission Tomography. Prognosis. Steroid 21-Hydroxylase / genetics. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19942208.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; EC 1.14.99.10 / CYP21A2 protein, human; EC 1.14.99.10 / Steroid 21-Hydroxylase
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91. Bahrami A, Truong LD, Shen SS, Krishnan B: Synchronous renal and adrenal masses: an analysis of 80 cases. Ann Diagn Pathol; 2009 Feb;13(1):9-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous renal and adrenal masses: an analysis of 80 cases.
  • Synchronous renal and adrenal masses are uncommon.
  • Although adrenal masses in the context of renal cell carcinoma (RCC) are often suspected as metastasis, other adrenal lesions with different therapeutic and prognostic implications may coexist with RCC.
  • In a retrospective review of 550 radical nephrectomies with ipsilateral adrenalectomy, 80 cases of coexisting renal and adrenal masses were identified.
  • The renal masses included 76 RCCs, 3 oncocytomas, and 1 malignant pheochromocytoma of adrenal gland involving the kidney.
  • Although the gross pathologic impression of adrenal masses in the presence of RCC was metastasis, on histologic examination, 56% of them were found to be benign lesions (mostly adrenal adenoma/hyperplasia), whereas malignant involvement from RCC was seen in 43%.
  • The benign and malignant nature of the adrenal lesions in the context of RCC could not be discriminated based on the size of adrenal mass.
  • Because of the prognostic implication of direct or metastatic involvement of adrenal gland in the setting of RCC and the possibility of finding small metastatic foci, a meticulous gross and microscopic examination of adrenal glands is emphasized.
  • Rare unusual combinations of renal and adrenal lesions such as RCC and adrenal histoplasmosis, RCC and adrenal myelolipoma, renal oncocytoma, and adrenal pheochromocytoma are also described.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Carcinoma, Renal Cell / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Adrenalectomy. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Nephrectomy. Pheochromocytoma / pathology. Pheochromocytoma / surgery. Retrospective Studies

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  • (PMID = 19118776.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Shin NY, Kim MJ, Chung JJ, Chung YE, Choi JY, Park YN: The differential imaging features of fat-containing tumors in the peritoneal cavity and retroperitoneum: the radiologic-pathologic correlation. Korean J Radiol; 2010 May-Jun;11(3):333-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Some of these fat-containing lesions, such as liposarcoma and retroperitoneal teratoma, have to be resected, although resection can be deferred for others, such as adrenal adenoma, myelolipoma, angiomyolipoma, ovarian teratoma, and lipoma, until the lesions become large or symptomatic.
  • Identifying factors such as whether the fat is macroscopic or microscopic within the lesion, the origin of the lesions, and the presence of combined calcification is important for narrowing the differential diagnosis.
  • The development and wide-spread use of modern imaging modalities make identification of these factors easier so narrowing the differential diagnosis is possible.
  • Classifying lesions in terms of the necessity of performing surgical treatment can provide important information to clinicians, and this is the one of a radiologist's key responsibilities.
  • [MeSH-minor] Abdominal Fat / pathology. Abdominal Fat / radiography. Adult. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Peritoneal Cavity / pathology. Peritoneal Cavity / radiography. Peritoneal Diseases / pathology. Peritoneal Diseases / radiography. Retroperitoneal Space / pathology. Retroperitoneal Space / radiography. Tomography, Spiral Computed / methods. Young Adult

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  • (PMID = 20461188.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 35
  • [Other-IDs] NLM/ PMC2864861
  • [Keywords] NOTNLM ; Abdominal cavity / Magnetic resonance (MR) / Neoplasm, adipose tissue / Retroperitoneal space / Tomography, spiral computed
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93. Sonino N, Bonnini S, Fallo F, Boscaro M, Fava GA: Personality characteristics and quality of life in patients treated for Cushing's syndrome. Clin Endocrinol (Oxf); 2006 Mar;64(3):314-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS: Twenty-four consecutive outpatients who were in remission upon proper treatment of Cushing's syndrome for at least 1 year and no more than 3 years (20 with pituitary-dependent Cushing's disease and four with a cortisol-secreting adrenal adenoma; 5 M/19 F; mean age 34.5, SD = 10.6; range 18-57 years) were compared with 24 healthy control subjects matched for sociodemographic variables.
  • The results did not change when the four patients with an adrenal adenoma were excluded and only the 20 with pituitary-dependent Cushing's disease were considered.
  • Again, no differences were found in evaluating the 20 patients with Cushing's disease separately.
  • The findings of a compromised quality of life are in agreement with the recent literature and have implications for the long-term management of patients.
  • [MeSH-minor] Adenoma / psychology. Adolescent. Adrenal Gland Neoplasms / psychology. Adult. Case-Control Studies. Female. Humans. Hydrocortisone / secretion. Male. Middle Aged. Personality Assessment. Prospective Studies. Psychometrics / methods. Stress, Psychological / psychology

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  • (PMID = 16487442.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
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94. Diab DL, Faiman C, Siperstein AE, Grossman WF, Rabinowitz LO, Hamrahian AH: Virilizing ovarian Leydig cell tumor in a woman with subclinical Cushing syndrome. Endocr Pract; 2008 Apr;14(3):358-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Virilizing ovarian Leydig cell tumor in a woman with subclinical Cushing syndrome.
  • OBJECTIVE: To report the case of a patient with a virilizing ovarian Leydig cell tumor and subclinical Cushing syndrome attributable to an adrenal adenoma.
  • RESULTS: A 49-year-old woman was referred for evaluation of a left adrenal mass (3.0 by 2.4 cm), which had been diagnosed by computed tomographic scan 4 years previously during a work-up for hirsutism.
  • A laparoscopic adrenalectomy revealed an adrenal adenoma.
  • At 6 months postoperatively, a normal result of a cosyntropin stimulation test indicated recovery of the hypothalamic-pituitary-adrenal axis.
  • Bilateral oophorectomy revealed a 1.3-cm right ovarian Leydig cell tumor.
  • CONCLUSION: To our knowledge, this is the first case report of a virilizing ovarian Leydig cell tumor in a patient with subclinical Cushing syndrome.
  • [MeSH-major] Cushing Syndrome / diagnosis. Leydig Cell Tumor / diagnosis. Ovarian Neoplasms / diagnosis. Virilism / diagnosis
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Female. Humans. Middle Aged. Testosterone / blood


95. Amar L, Lepoutre C, Bobrie G, Plouin PF: [Endocrine hypertension]. Rev Med Interne; 2010 Oct;31(10):697-704
MedlinePlus Health Information. consumer health - High Blood Pressure.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This entity encompasses several diseases including primary aldosteronism, paraganglioma/pheochromocytoma and Cushing's syndrome.
  • (3) the coexistence of hypertension with an adrenal adenoma, clinical or biological abnormalities.
  • Screening is performed by the measurement of several hormones and by a tomodensitometry to study the morphology of the adrenals: the presence of a solitary or multiples adenomas, or hyperplasia.
  • Once the diagnosis is obtained, it is essential to differentiate whether it is a surgically correctable form or not.
  • The patients with a bilateral adrenal hyperplasia can be managed effectively by mineralocorticoids receptor antagonist.
  • The diagnosis and the treatment of these disorders can be challenging.
  • However, the diagnosis of endocrine hypertension allows diagnosing surgical correctable form of hypertension, which is not possible in essential hypertension.

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  • [Copyright] Copyright © 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20674105.001).
  • [ISSN] 1768-3122
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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96. Kau T, Reinprecht P, Eicher W, Lind P, Starlinger M, Hausegger KA: FDG PET/CT in the detection of recurrent rectal cancer. Int Surg; 2009 Oct-Dec;94(4):315-24
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  • Sites of increased FDG uptake as well as PET/CT findings were categorized as benign (1), equivocal (2), or malignant (3).
  • Sensitivity, specificity, positive and negative predictive values, and accuracy for differentiating benign (14/31) from malignant (17/31) uptake sites in the small pelvis were 100%, 64%, 77%, 100%, and 84% for PET/CT, and 100%, 29%, 63%, 100%, and 68% for PET, respectively.
  • Regarding extrapelvic abnormalities, PET/CT was able to distinguish benign (31/88) from malignant (57/88) with a sensitivity, specificity, positive and negative predictive values, and accuracy of 100%, 87%, 93%, 100%, and 95%, compared with 96%, 68%, 85%, 91%, and 86% for PET.
  • The rare case of an FDG uptake of adrenal adenoma is documented.
  • PET/CT is valuable in the staging of rectal cancer, particularly for excluding recurrent disease suspected by PET interpretation alone in a considerable number of patients.

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  • (PMID = 20302028.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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97. Myint KS, Watts M, Appleton DS, Lomas DJ, Jamieson N, Taylor KP, Coghill S, Brown MJ: Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertension. J Renin Angiotensin Aldosterone Syst; 2008 Jun;9(2):103-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertension.
  • The diagnosis of primary hyperaldosteronism due to microadenoma or unilateral adrenal hyperplasia can be challenging, since hypokalaemic alkalosis, high plasma aldosterone and a definite adenoma on imaging may all be absent.
  • METHOD AND RESULT: We describe three cases of resistant hypertension (on > or = 5 antihypertensives) where hyperaldosteronism was suspected because of a suppressed plasma renin level despite treatment with multiple drugs which normally elevate renin.
  • Hypokalaemia was present in the first two cases but computed tomography did not show clear cut adenomas.
  • Adrenal vein sampling (AVS) revealed lateralisation (> 4 times higher aldosterone to cortisol ratio (ACR) on the affected than contra-lateral side).
  • A suppressed plasma renin indicates abnormal Na+-retention, and--when not overcome by drugs such as angiotensin-converting enzyme-inhibitors or angiotensin receptor blockers--may be the only clue to a curable adrenal adenoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Hyperaldosteronism / etiology. Hypertension / etiology. Hypertension / therapy

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  • (PMID = 18584586.001).
  • [ISSN] 1470-3203
  • [Journal-full-title] Journal of the renin-angiotensin-aldosterone system : JRAAS
  • [ISO-abbreviation] J Renin Angiotensin Aldosterone Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin; WI4X0X7BPJ / Hydrocortisone
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98. Aliaev IuG, Akhvlediani ND, Blokhin PS: [Ipsilateral adrenalectomy is not obligatory in nephrectomy for renal cell carcinoma]. Urologiia; 2008 Mar-Apr;(2):16-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ipsilateral adrenalectomy is not obligatory in nephrectomy for renal cell carcinoma].
  • To analyse the necessity of obligatory ipsilateral adrenalectomy (IA) for renal cell carcinoma (RCC), we made a study of 329 RCC patients operated from 2002 to 2007.
  • Nephrectomy was conducted in 208 (63.2%) patients, renal resection--in 121 (36.8%), adrenalectomy--in 19 (5.8%) patients.
  • Preoperative HCMCT detected adrenal lesions in 62 (18.84%) patients.
  • Adrenal adenoma was suspected in 39 (11.8%) patients: ipsilateral in 19 (48.77%), contralateral in 11 (28.23%), bilateral in 9 (23%) patients.
  • Adrenal hyperplasy was diagnosed in 11 (3.34%) patients.
  • The tumor invaded the ipsilateral adrenal in 4 (1.2%) patients.
  • A RCC metastasis into the adrenal was suspected in 8 (2.4%) patients.
  • RCC invaded the ipsilateral adrenal in 1.2% patients with RCC, its adrenal metastasis was detected in 1.5% RCC patients.
  • In preservation of the adrenal in adenoma or hyperplasy 5-year follow-up registered no changes.
  • Neither pathological processes were diagnosed for 5 years in preservation of unaffected adrenal.
  • [MeSH-major] Adrenalectomy. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods
  • [MeSH-minor] Adenoma / pathology. Adenoma / radiography. Adenoma / surgery. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radiography. Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 18574876.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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99. Nicol MR, Papacleovoulou G, Evans DB, Penning TM, Strachan MW, Advani A, Johnson SJ, Quinton R, Mason JI: Estrogen biosynthesis in human H295 adrenocortical carcinoma cells. Mol Cell Endocrinol; 2009 Mar 5;300(1-2):115-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Estrogen biosynthesis in human H295 adrenocortical carcinoma cells.
  • Adrenocortical carcinoma is an uncommon malignancy and feminizing symptoms secondary to adrenal estrogen-secretion are extremely rare.
  • The direct secretion of estradiol by adrenocortical tumors requires, in addition to the expression of aromatase (CYP19), the expression of one or more of the reductive 17beta-hydroxysteroid dehydrogenases.
  • The expression of CYP19 transcripts and protein were markedly induced in the H295 adrenocortical carcinoma cell line after treatment with either forskolin or vasoactive intestinal peptide (VIP).
  • Western immunoblotting of an estrogen-secreting adrenal carcinoma revealed notable levels of both aromatase and AKR1C3 expression while an aldosterone-producing adrenal adenoma lacked aromatase expression and showed a reduced level of AKR1C3 expression.
  • Immunohistochemistry of the carcinoma-bearing adrenal revealed localization of AKR1C3 not only in the tumor but also principally in the zona reticularis of the normal adrenal tissue.
  • Adrenal aromatase and AKR1C3 expression therefore appear to be features of adrenocortical malignancies that are associated with biosynthesis of active estrogen.

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  • (PMID = 19026713.001).
  • [ISSN] 0303-7207
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090744-07; United States / NCI NIH HHS / CA / R01 CA090744; United States / NCI NIH HHS / CA / R01 CA090744-07; United States / NCI NIH HHS / CA / R01-CA90744
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Estrogens; 1F7A44V6OU / Colforsin; 37221-79-7 / Vasoactive Intestinal Peptide; EC 1.1.- / 17-Hydroxysteroid Dehydrogenases; EC 1.1.- / 3-Hydroxysteroid Dehydrogenases; EC 1.1.1.- / AKR1C3 protein, human; EC 1.1.1.- / Hydroxyprostaglandin Dehydrogenases; EC 1.1.1.145 / 3 beta-hydroxysteroid dehydrogenase type II; EC 1.1.1.145 / Progesterone Reductase; EC 1.14.14.1 / Aromatase; EC 1.14.15.4 / Cytochrome P-450 CYP11B2; EC 1.14.15.4 / Steroid 11-beta-Hydroxylase; EC 1.14.99.9 / Steroid 17-alpha-Hydroxylase
  • [Other-IDs] NLM/ NIHMS99072; NLM/ PMC2673546
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100. Chiodini I, Scillitani A: [Role of cortisol hypersecretion in the pathogenesis of osteoporosis]. Recenti Prog Med; 2008 Jun;99(6):309-13
MedlinePlus Health Information. consumer health - Osteoporosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Alendronate has been demonstrated to be useful to accelerate the restoration of normal bone mass after the cure of Cushing's syndrome Several studies, even not all, have been demonstrated that also the condition of asymptomatic or "subclinical" hypercortisolism (often associated to adrenal adenoma) is associated to a reduction of bone mineral density and increased prevalence of fracture even in the presence of eugonadal status and in males.
  • This finding suggests that the presence of subclinical hypercortisolism has to be taken in to account when evaluating patients with unexplainable established osteoporosis.
  • [MeSH-minor] Adrenocortical Hyperfunction / complications. Bone Density. Evidence-Based Medicine. Humans

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  • (PMID = 18710063.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Editorial; English Abstract; Review
  • [Publication-country] Italy
  • [Number-of-references] 36
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