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1. Schanz A, Richter J, Beyer I, Baldus SE, Hess AP, Kruessel JS: Genital schistosomiasis as a cause of female sterility and acute abdomen. Fertil Steril; 2010 Apr;93(6):2075.e7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To report the case of a Nigerian patient who suffered from sterility and underwent abdominal laparotomy to remove an adnexal tumor.
  • PATIENTS: One patient who underwent an abdominal laparotomy to remove an adnexal tumor.
  • INTERVENTION(S): In vitro fertilization and adnexal tumor resection via laparotomy.
  • MAIN OUTCOME MEASURE(S): Treatment of the adnexal tumor affecting the reproductive health.

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  • [Copyright] Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20138271.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Kamiya H, Kitajima Y, Ban M: Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells. J Dermatol; 2006 Dec;33(12):858-64
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  • [Title] Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
  • Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions.
  • Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition.
  • Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma.
  • In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma.
  • The tumor in case 2 was characteristic to trichilemmal carcinoma.
  • Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma, Skin Appendage / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology

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  • (PMID = 17169090.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Porter E, McGregor A, Brown L, Davies Q: Solitary fibrous tumour of round ligament mimicking a leiomyoma. J Obstet Gynaecol; 2008 May;28(4):463-4
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  • [Title] Solitary fibrous tumour of round ligament mimicking a leiomyoma.
  • [MeSH-major] Adnexal Diseases / pathology. Leiomyoma / pathology. Round Ligament of Uterus / pathology. Solitary Fibrous Tumors / pathology. Uterine Neoplasms / pathology

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  • (PMID = 18604703.001).
  • [ISSN] 1364-6893
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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4. Kazakov DV, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, Grossmann P, Michal M: Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol; 2009 May;31(3):248-55
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  • [Title] Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
  • Previous studies suggested that mutant beta-catenin gene cells in cutaneous adnexal tumors with matrical differentiation contribute to their tumorigenesis.
  • Except for pilomatricoma and pilomatrical carcinoma, only a handful of other cutaneous adnexal tumor types have been studied.
  • DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene.
  • These included 5 different point mutations, 3 of them identified in 2 different tumors: S23N (cribriform trichoblastoma), D32Y (pilomatricoma and craniopharyngioma), G34R (pilomatrical carcinoma and craniopharyngioma), S37F (2 BCCs with shadow cell differentiation), and G34V (craniopharyngioma).
  • This study broadens the list of cutaneous adnexal tumors harboring CTNNB1 mutations and extends the listing of the mutations occurring in these neoplasms.
  • [MeSH-major] Exons. Mutation. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics. beta Catenin / genetics

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  • (PMID = 19384065.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
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5. Alexander MP, Makhija P, Jayaseelan E: Fine needle aspiration cytology of trichofolliculoma: a case report. Indian J Pathol Microbiol; 2007 Oct;50(4):870-2
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  • The cytomorphology of skin adnexal tumours has not been described extensively in literature.
  • Cytology is a useful tool in the diagnosis of skin adnexal tumours.
  • [MeSH-major] Hair Follicle / pathology. Hamartoma / diagnosis. Hamartoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 18306593.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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6. Navi D, Fung M, Lynch PJ: Poromatosis: the occurrence of multiple eccrine poromas. Dermatol Online J; 2008;14(1):3
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  • Eccrine poromas are rare, benign adnexal tumors derived from the intraepidermal portion of sweat ducts.
  • They usually appear as solitary, slow-growing, skin-colored papules on acral surfaces.
  • Here we present the unusual situation of a patient with multiple poromas only three of which are located near the distal extremities.

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  • (PMID = 18319020.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Huang W, Zhao Y, Zhao J, Huang Y, Wang J, Zhang Q: Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature. Pathol Res Pract; 2010 Mar 15;206(3):180-4
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  • [Title] Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature.
  • Endometrioid carcinoma is a common tumor of the female genital tract, mainly affecting the uterus corpus and ovary.
  • The female adnexal tumor of probable wolffian origin (FATWO), although occasionally seen elsewhere, is most typically encountered in the broad ligament.
  • The tumor was confined to the tube and strongly resembled FATWO.
  • Immunohistochemically, the tumor cells were positive for AE1/AE3, epithelial membrane antigen (EMA), and p16, but negative for CD10, inhibin-alpha, calretinin, vimentin, myogenin, and desmin, CD99,CgA, and Syn.
  • We review the previously published cases of endometrioid carcinomas of the fallopian tube resembling FATWO, and discuss the principal differential diagnosis of the tumor in the fallopian tube.
  • [MeSH-major] Endometrial Neoplasms / pathology. Fallopian Tube Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19457622.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
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8. Ramos-Ceballos FI, Pashaei S, Kincannon JM, Morgan MB, Smoller BR: Bcl-2, CD34 and CD10 expression in basaloid follicular hamartoma, vellus hair hamartoma and neurofollicular hamartoma demonstrate full follicular differentiation. J Cutan Pathol; 2008 May;35(5):477-83
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  • BFH is a benign adnexal tumor that resembles basal cell carcinoma (BCC).
  • In this study, we report two cases of GBFHS and stain BFH, a vellus hair hamartoma (VHH) and a neurofollicular hamartoma (NH) with CD34, bcl-2 and CD10 to characterize and compare the staining patterns of these follicular tumors.
  • Bcl-2 stains the outermost cell layer of these tumors.
  • These results show the similarities in differentiation between these benign follicular neoplasms and trichoepithelioma.

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  • [CommentIn] J Cutan Pathol. 2009 May;36(5):603; author reply 604 [19476535.001]
  • (PMID = 18399809.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Proto-Oncogene Proteins c-bcl-2; EC 3.4.24.11 / Neprilysin
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9. Yazbek J, Ameye L, Timmerman D, Testa AC, Valentin L, Holland TK, Van Holsbeke C, Jurkovic D: Use of ultrasound pattern recognition by expert operators to identify borderline ovarian tumors: a study of diagnostic performance and interobserver agreement. Ultrasound Obstet Gynecol; 2010 Jan;35(1):84-8
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  • [Title] Use of ultrasound pattern recognition by expert operators to identify borderline ovarian tumors: a study of diagnostic performance and interobserver agreement.
  • OBJECTIVE: To assess the accuracy and reproducibility of ultrasound 'pattern recognition' for the diagnosis of borderline ovarian tumors by asking experienced ultrasound operators to evaluate representative images of different types of adnexal tumor.
  • METHODS: Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed by three expert sonologists who had not performed the original real-time ultrasound examination.
  • The outcome measures included diagnostic accuracy and interobserver agreement in the diagnosis of benign, borderline or invasive malignant ovarian tumors.
  • A correct classification was made by all three experts in 83% of the primary invasive cancers, 76% of the benign masses and in 44% of the borderline malignant tumors (P < 0.01).
  • The experts showed a tendency to misclassify borderline tumors as benign rather than primary invasive (ratio of 8 : 1 for Expert A, 4 : 1 for B and 6 : 1 for C).
  • The interobserver agreement between any two experts was very good when they were tested for their ability to discriminate between invasive and non-invasive (benign and borderline) ovarian tumors (Cohen's kappa 0.85-0.88), but poorer for the discrimination between malignant (invasive and borderline) and benign tumors (kappa 0.70-0.78).
  • CONCLUSIONS: The accuracy of ultrasound diagnosis of borderline tumors is lower in comparison with benign and invasive malignant lesions.
  • The diagnostic performance and interobserver agreement are better when the outcomes are dichotomized into non-invasive and invasive malignant lesions, as opposed to the traditional diagnosis of benign and malignant tumors.
  • [MeSH-major] Adnexal Diseases / ultrasonography. Ovarian Neoplasms / ultrasonography. Pattern Recognition, Visual

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  • (PMID = 19746450.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Regauer S: Extramammary Paget's disease--a proliferation of adnexal origin? Histopathology; 2006 May;48(6):723-9
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  • [Title] Extramammary Paget's disease--a proliferation of adnexal origin?
  • EPD is a predominantly intraepidermal tumour with extensive involvement of adnexal structures and high recurrence rates suggesting a follicular stem cell origin.
  • (iii) since both cell types express cytokeratins typical for follicular differentiation, EPD may be a proliferation of adnexal stem cells residing in the infundibulo-sebaceous unit of hair follicles and adnexal structures.

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  • (PMID = 16681689.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / KRT15 protein, human; 0 / Keratin-15; 68238-35-7 / Keratins
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11. Moszyński R, Szpurek D, Pawlak M, Englert-Golon M, Sajdak S: [The influence of ovarian tumour histopathological diagnosis on prognostic values of the sonomorphological index]. Ginekol Pol; 2006 Jul;77(7):516-22
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  • [Title] [The influence of ovarian tumour histopathological diagnosis on prognostic values of the sonomorphological index].
  • OBJECTIVES: The purpose of the study was to evaluate the helpfulness of sonomorphological index in preoperative diagnosis of ovarian tumours.
  • MATERIAL AND METHOD: 686 patients diagnosed and treated because of adnexal tumours were analyzed.
  • At the admission day the patient underwent an ultrasonographical examination that stated morphology of tumour using the sonomorphological index (SM).
  • During the study, histopathological types of ovarian tumours with the lowest prognostic values were appointed.
  • Among malignant tumours the lowest sensitivity of the test corresponded with: dysgerminoma and folliculoma.
  • Among benign tumours the lowest helpfulness in preoperative diagnosis of ovarian tumours the sonomorphological index demonstrated in following histopathological types: mucinouse cystadenoma and adult teratoma.
  • CONCLUSIONS: In all histopathological types of malignant and benign tumours mentioned above, the use of the sonomorphological index require caution.

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  • (PMID = 17076201.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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12. Obaidat NA, Ghazarian DM: A proliferating composite adnexal tumour of the penis: report of the first case. J Clin Pathol; 2007 May;60(5):567-9
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  • [Title] A proliferating composite adnexal tumour of the penis: report of the first case.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Penile Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17513517.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Ghaemmaghami F, Fakour F, Karimi Zarchi M, Behtash N, Modares Gilani M, Mousavi A, Shariat M: Clinical assessment, gross examination, frozen section of ovarian masses: do patients benefit? Arch Gynecol Obstet; 2008 Sep;278(3):209-13
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  • Differentiating benign and malignant disease with frozen section is possible during operation; however, information on patients' history, physical examination, paraclinical criteria (tumour markers, imaging) and gross examination of tumour can also be helpful in planing the surgery.
  • METHODS: This study was conducted on 150 women who underwent laparotomy due to adnexal mass between April 2003 and October 2005 at Vali-e-Asr Hospital, Tehran, Iran.
  • Sensitivity and specificity of clinical assessment (history, tumour marker and imaging), gross examination and frozen section were calculated.
  • RESULTS: Based on our findings frozen section had the highest sensitivity for diagnosing malignant tumour comparing with other methods of diagnosis (88.9%).

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  • (PMID = 18259768.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-125 Antigen
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14. Kaushik V, Bhalla RK, Nicholson C, de Carpentier JP: The chondroid syringoma: report of a case arising from the external auditory canal. Eur Arch Otorhinolaryngol; 2005 Oct;262(10):868-70
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  • [Title] The chondroid syringoma: report of a case arising from the external auditory canal.
  • Chondroid syringoma is an uncommon, benign skin adnexal tumour.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ear Canal. Ear Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 15739085.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Publication-type] Case Reports; Journal Article
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15. Gaffar M, Thebpatiphat N, Przygodzki R, Jacobs S, Miller MM: Primary follicular lymphoma of the conjunctiva in a 6-year-old child. J AAPOS; 2010 Dec;14(6):538-40
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  • Ocular adnexal tumors are rare.
  • We report the case of a 6-year-old boy with a 3-mm conjunctival mass.

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  • [Copyright] Copyright © 2010 American Association for Pediatric Ophthalmology and Strabismus. All rights reserved.
  • (PMID = 21093330.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Iura A, Sasajima Y, Katsumata N, Kasamatsu T: Serous adenocarcinoma of the retroperitoneum, as a type of multifocal müllerian carcinoma. Int J Clin Oncol; 2009 Jun;14(3):254-7
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  • On MRI, the tumor was 17 x 10 x 6 cm in size and monocystic.
  • The tumor cells were positive for CA125, estrogen receptor, and Wilms tumor 1, and were differentiated from enterogenic cyst by the presence of cytokeratin 7 (+), and the absence of cytokeratin 20 (-).
  • Simultaneously, uterine adnexal serous adenocarcinoma was detected.
  • The volume of the retroperitoneal tumor was 14 times larger than that of the uterine adnexal tumor.
  • We suggest the possibility that the retroperitoneal cancer arose as a primary cancer from rests of the müllerian epithelium synchronously with the uterine adnexal cancer.
  • The patient had been taking conjugated estrogen for 10 years, suggesting that long-term estrogen stimulation may have contributed to the progression of the tumors.
  • [MeSH-major] Adnexa Uteri / pathology. Cystadenocarcinoma, Serous / pathology. Mullerian Ducts / pathology. Peritoneal Neoplasms / pathology

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  • [Cites] Histopathology. 2002 Feb;40(2):171-6 [11952862.001]
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  • (PMID = 19593619.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Dowd MB, Kumar RJ, Sharma R, Murali R: Diagnosis and management of sebaceous carcinoma: an Australian experience. ANZ J Surg; 2008 Mar;78(3):158-63
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  • BACKGROUND: Cutaneous sebaceous carcinoma (SC) is a rare malignancy derived from adnexal epithelium of sebaceous glands.
  • To date, there are few data from an Australian source to document the prevalence or clinical outcome of this tumour.
  • Three metastases and one tumour showed extensive local invasion.
  • CONCLUSION: Sebaceous carcinoma is a rare tumour.

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  • [CommentIn] ANZ J Surg. 2009 Apr;79(4):306-7 [19432724.001]
  • (PMID = 18269479.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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18. Bats AS, Larousserie F, Le Frère-Belda MA, Metzger U, Lécuru F: Usefulness of routine intraoperative staging of suspicious adnexal tumours: illustration by two cases of adult granulosa cell tumour. Eur J Gynaecol Oncol; 2010;31(2):206-8
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  • [Title] Usefulness of routine intraoperative staging of suspicious adnexal tumours: illustration by two cases of adult granulosa cell tumour.
  • Granulosa cell tumours (GCTs) account for less than 3% of all ovarian malignancies but are among the most common sex cord-stromal tumours.
  • Symptoms related to oestrogen production by the tumour may occur.
  • [MeSH-major] Granulosa Cell Tumor / pathology. Gynecologic Surgical Procedures / methods. Neoplasm Staging / methods. Ovarian Neoplasms / pathology

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  • (PMID = 20527242.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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19. Veyer L, Marret H, Bleuzen A, Simon E, Body G, Tranquart F: Preoperative diagnosis of ovarian tumors using pelvic contrast-enhanced sonography. J Ultrasound Med; 2010 Jul;29(7):1041-9
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  • [Title] Preoperative diagnosis of ovarian tumors using pelvic contrast-enhanced sonography.
  • OBJECTIVE: The purpose of this study was to assess the feasibility of using a contrast agent for the sonographic examination of adnexal tumors and identify discriminating parameters in the preoperative diagnosis of malignant tumors.
  • Patients included were referred for a second opinion after the discovery of a suspicious ovarian image.
  • RESULTS: Fifty-two tumors were analyzed.
  • Morphologic and Doppler criteria analyses were conducted as described in the literature.
  • When borderline tumors were eliminated, there was an inversion of this, with an AUC of 0.85 versus 0.73.
  • The inclusion of contrast results in the examiner's diagnosis in the context of a bivariate model comparing malignant and borderline tumors with benign tumors provided an AUC of 0.88.
  • CONCLUSIONS: Contrast-enhanced sonography improves preoperative diagnosis of ovarian tumors parameters.
  • The significant parameters of the enhancement curve were significantly different for malignant and benign tumors.
  • Borderline tumors contribute to a reduction of the discriminating capacity of the contrast agent.

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  • (PMID = 20587427.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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20. Nishikawa Y, Kaneko T, Takiyoshi N, Aizu T, Nakajima K, Matsuzaki Y, Nakano H, Sawamura D: Dermoscopy of eccrine poroma with calcification. J Dermatol Case Rep; 2009 Nov 28;3(3):38-40
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  • BACKGROUND: Eccrine poromas are relatively common slow-growing benign solitary adnexal tumors originating from the intraepidermal portion of the eccrine sweat duct (acrosyringium).
  • MAIN OBSERVATIONS: A 73-year-old man with hemiparesis, who had a 10-year history of tumor on his right palm, which was occasionally injured by a walking crutch, causing bleeding and ulceration.
  • Physical examination revealed a pigmented dome-shaped tumor.
  • Histological examination revealed that the tumor was composed of cords of tumor cells extending from the epidermis into the dermis.
  • The tumor showed cystic structures and calcification.
  • CONCLUSIONS: Although cutaneous neoplasms commonly associated with calcification are of follicular origin, it is known that dystrophic calcification may be triggered also in tumors of eccrine origin by multiple factors, including mechanical injury.

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  • [Cites] Br J Dermatol. 2001 Jan;144(1):146-50 [11167697.001]
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  • (PMID = 21886728.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157797
  • [Keywords] NOTNLM ; Pinkus type / adnexal tumors / calcification / dermoscopy / eccrine gland / local tissue injury
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21. Kupesic S, Plavsic BM: Early ovarian cancer: 3-D power Doppler. Abdom Imaging; 2006 Sep-Oct;31(5):613-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Color Doppler imaging and pulsed Doppler spectral analysis enable evaluation of ovarian tumor blood flow, analysis of the distribution of blood vessels, and quantitative measurement of blood flow velocity waveforms.
  • These parameters increase the sensitivity and specificity of ultrasound evaluation of ovarian tumors.
  • Three-dimensional (3-D) power Doppler ultrasound provides a new tool to evaluate features of tumor vascularity.
  • Contrast-enhanced 3-D power Doppler sonography facilitates visualization of adnexal tumor vessels, which may aid in differentiating benign from malignant adnexal lesions.

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  • (PMID = 16447081.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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22. Giger O, Caduff R, O'Meara A, Diener PA, Knuth A, Jäger D, Moch H, Varga Z: Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease. Pathol Int; 2010 Nov;60(11):726-34
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  • Recently NY-BR-1, a differentiation antigen expressed in the breast and in skin adnexal structures was identified.
  • Its protein expression is restricted to normal and neoplastic breast epithelium and to adnexal tumors of the skin.

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 20946522.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / breast cancer antigen NY-BR-1, human
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23. Baxi S, Deb S, Weedon D, Baumann K, Poulsen M: Microcystic adnexal carcinoma of the skin: the role of adjuvant radiotherapy. J Med Imaging Radiat Oncol; 2010 Oct;54(5):477-82
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  • [Title] Microcystic adnexal carcinoma of the skin: the role of adjuvant radiotherapy.
  • INTRODUCTION: Microcystic adnexal carcinoma (MAC) is a rare cutaneous tumour where the role of radiotherapy remains undefined.
  • All cases occurred in the head and neck region with mean tumour size of 20.5 mm and mean depth of invasion of 9.9 mm.
  • There was no evidence that radiotherapy can cause aggressive transformation of the tumour.
  • [MeSH-major] Carcinoma, Skin Appendage / radiotherapy. Head and Neck Neoplasms / radiotherapy. Radiotherapy, Adjuvant. Skin Neoplasms / radiotherapy. Sweat Gland Neoplasms / radiotherapy

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  • [Copyright] © 2010 The Authors. Journal of Medical Imaging and Radiation Oncology © 2010 The Royal Australian and New Zealand College of Radiologists No claim to original US government works.
  • (PMID = 20958947.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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24. Nogales FF, Stolnicu S, Harilal KR, Mooney E, García-Galvis OF: Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract. Histopathology; 2009 Mar;54(4):471-7
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  • [Title] Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract.
  • AIMS: To analyse both the clinicopathological and immunohistochemical findings in six cases of uterine tumours resembling ovarian sex cord tumours with a predominant epithelial retiform component resembling the rete ovarii (RUTROSCT) and to compare their immunophenotype with tissues containing retiform structures such as the normal rete ovarii, retiform Wolffian adnexal tumour (RWAT) and ovarian retiform areas of Sertoli-Leydig cell tumours (ORSLCT).
  • The average age of patients was 65 years, and all tumours behaved in a benign fashion.
  • Histologically they had a tubulopapillary or glomeruloid formation; a sex-cord-like or endometrial stromal component was absent or comprised at most 30% of the tumour.
  • CONCLUSIONS: RUTROSCTs have benign behaviour but may be confused with various uterine adenocarcinomas or metastases.
  • [MeSH-major] Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / metabolism. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Calbindin 2. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Inhibins / metabolism. Keratin-7 / metabolism. Middle Aged. Mucin-1 / metabolism. Neprilysin / metabolism. S100 Calcium Binding Protein G / metabolism. Sertoli-Leydig Cell Tumor / metabolism. Sertoli-Leydig Cell Tumor / pathology

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  • [CommentIn] Histopathology. 2009 Nov;55(5):619-20; author reply 620-1 [19912370.001]
  • (PMID = 19309399.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Keratin-7; 0 / Mucin-1; 0 / S100 Calcium Binding Protein G; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.4.24.11 / Neprilysin
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25. Flores-Alvarez E, Tello-Brand SE, López-López F, Rivera-Barragán V: Peritoneal tuberculosis. Report of seven cases. Cir Cir; 2010 Jan-Feb;78(1):67-71
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  • The most frequent clinical data were abdominal pain (six patients), ascites (four patients), and abdominal tumor (three patients).
  • Abdominopelvic CT examinations revealed unilateral ovarian tumor in four patients, bilateral ovarian tumor in two patients, ascites in four patients, and retroperitoneal adenopathy in one patient.
  • All patients had a preoperative diagnosis of malignant tumor.
  • Diagnoses should be considered in all patients with ascites, adnexal tumors and elevated serum CA-125 levels.

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  • (PMID = 20226130.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Biomarkers; 0 / CA-125 Antigen
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26. Zhang Q, Wojno TH, Fitch SD, Grossniklaus HE: Mucinous eccrine adenocarcinoma of the eyelid: report of 6 cases. Can J Ophthalmol; 2010 Feb;45(1):76-8
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  • CONCLUSIONS: Mucinous eccrine adenocarcinoma is an uncommon adnexal tumour that can involve the eyelid, has low metastasis and mortality, but can be invasive or locally recur.

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  • [ISSN] 1715-3360
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / P30 EY006360; None / None / / P30 EY006360-25; United States / NEI NIH HHS / EY / P30 EY006360-25
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27. Braun-Falco M: [Skin tumours of the facial area]. HNO; 2009 Apr;57(4):302-14
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  • [Title] [Skin tumours of the facial area].
  • Almost the complete spectrum of skin tumours can occur within the facial area, ranging from benign tumours of infancy to typical malignancies of old age.
  • This spectrum is quiet heterogeneous and comprises every cell type within the skin as a possible origin for tumour growth.
  • Among these are cells derived from the epidermis; adnexal structures; connective, fatty, and vascular tissue; muscle; nerves; melanocytes; and skin-infiltrating inflammatory cells.
  • The present overview aims to summarise the basics of the most frequent and most important skin tumours occurring on the face.
  • [MeSH-major] Dermatology / trends. Facial Neoplasms / diagnosis. Facial Neoplasms / therapy. Otolaryngology / trends. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 19322550.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 100
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28. Fullen DR, Garrisi AJ, Sanders D, Thomas D: Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays. J Cutan Pathol; 2008 Nov;35 Suppl 2:28-34
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  • [Title] Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays.
  • BACKGROUND: S100A6, a calcium-binding protein in the S100 family, has been observed in melanocytic nevi, neural tumors, fibrohistiocytic tumors and is overexpressed in melanoma.
  • Limited data on S100A6 expression in cutaneous epithelial tumors exists in the literature.
  • The goal of this study was to determine the specificity and sensitivity of S100A6 protein in a spectrum of cutaneous mesenchymal or epithelial tumors.
  • METHODS: Tissue microarrays of cutaneous epithelial neoplasms, mesenchymal neoplasms, DM and malignant peripheral nerve sheath tumors (MPNST) were stained with S100A6 antibody.
  • Four of seven microcystic adnexal carcinomas (MAC) stained for S100A6.
  • Tumors with duct differentiation variously expressed S100A6 protein, with two hidradenomas showing the strongest staining.
  • Malignant spindle cell tumors, with the exception of 13 of 30 MPNST, had a high incidence of S100A6 positivity.
  • CONCLUSIONS: S100A6 expression may distinguish SCC from BCC, MAC from BCC and hidradenoma from other adnexal tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cell Cycle Proteins / biosynthesis. S100 Proteins / biosynthesis. Skin Neoplasms / diagnosis. Skin Neoplasms / metabolism
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Diagnosis, Differential. Humans. Melanoma / diagnosis. Melanoma / metabolism. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / metabolism. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / metabolism. Tissue Array Analysis

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  • (PMID = 18201235.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / S100 Proteins; 105504-00-5 / S100A6 protein, human
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29. Franzin CM, Marussi EF, Zeferino LC, Sarian LO, Prada MF: [Association between sonographic findings and histological diagnosis of 446 ovarian tumors]. Rev Assoc Med Bras (1992); 2006 May-Jun;52(3):176-81
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  • [Title] [Association between sonographic findings and histological diagnosis of 446 ovarian tumors].
  • [Transliterated title] Correlação entre as características ultra-sonográficas e o diagnóstico histológico de 446 tumores ovarianos.
  • Patients who had been submitted to surgery due to uni or bilateral ovarian tumors were included and those presenting with an ectopic pregnancy or pelvic inflammatory process were excluded.
  • The magnitude of the associations between pathology diagnoses and sonographic morphologic findings where estimated by the Odds Ratio with its respective confidence intervals of 95%.
  • RESULTS: In their majority, masses were benign tumors (88.1%).
  • CONCLUSION: Sonographic analyses of adnexal tumors having more than 7 cm of diameter, irregular and poorly delimited external borders, presenting complex or anechoic textures with thickened septa or solid mass are highly suggestive of malignancy.

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  • (PMID = 16847525.001).
  • [ISSN] 0104-4230
  • [Journal-full-title] Revista da Associação Médica Brasileira (1992)
  • [ISO-abbreviation] Rev Assoc Med Bras (1992)
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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30. Yazbek J, Ameye L, Testa AC, Valentin L, Timmerman D, Holland TK, Van Holsbeke C, Jurkovic D: Confidence of expert ultrasound operators in making a diagnosis of adnexal tumor: effect on diagnostic accuracy and interobserver agreement. Ultrasound Obstet Gynecol; 2010 Jan;35(1):89-93
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  • [Title] Confidence of expert ultrasound operators in making a diagnosis of adnexal tumor: effect on diagnostic accuracy and interobserver agreement.
  • OBJECTIVE: To assess the degree of confidence with which expert ultrasound operators make a diagnosis of benign, borderline and invasive malignant ovarian tumors and its effect on diagnostic accuracy and interobserver agreement.
  • METHOD: Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed by three expert ultrasound operators who had not performed the original real-time ultrasound examination.
  • The experts classified the tumors as benign, borderline or invasive malignant and they also indicated the degree of confidence with which they made the diagnosis (certain, probable and uncertain).
  • The diagnostic accuracy and interobserver agreement, in differentiating benign, borderline and invasive malignant ovarian tumors, were calculated depending on the level of confidence with which the diagnosis was made.
  • The agreement in both diagnosis and confidence was lowest in cases of borderline ovarian tumors compared to benign and primary invasive lesions.
  • [MeSH-major] Adnexal Diseases / ultrasonography. Ovarian Neoplasms / ultrasonography

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  • (PMID = 19757401.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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31. Mataix J, Bañuls J, Botella R, Laredo C, Lucas A: [Brooke-Spiegler syndrome: an heterogeneous entity]. Actas Dermosifiliogr; 2006 Dec;97(10):669-72
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  • [Transliterated title] Síndrome de Brooke-Spiegler: una entidad heterogénea.
  • The Brooke-Spiegler syndrome is a rare, autosomally dominant disease with a predisposition to develop different adnexal tumors.
  • In this article we present the case of a woman and her daughter, both affected by this rare genodermatosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Neoplasms, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 17173833.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 30
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32. Krahl D, Sellheyer K: p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology. Br J Dermatol; 2010 Jul;163(1):138-45
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  • [Title] p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology.
  • BACKGROUND: Tumour development is frequently described in the basic pathology literature as a recapitulation of embryogenesis.
  • However, a link between the embryology of the skin and the histogenesis of adnexal tumours has been largely overlooked.
  • We therefore speculated that it is involved in the histogenesis of follicular adnexal tumours.
  • In contrast, the lack of p75NTR expression in morphoeic basal cell carcinoma favours a concept of this tumour as a more primitive follicular lesion with the characteristics of a carcinoma and not a hamartoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Hair Follicle / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptor, Nerve Growth Factor / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Merkel Cells / metabolism. Middle Aged. Skin / embryology. Skin / metabolism

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  • (PMID = 20184585.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptor, Nerve Growth Factor
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33. Triaridis S, Papadopoulos S, Tsitlakidis D, Printza A, Grosshans E, Cribier B: Trichoblastic carcinoma of the pinna. A rare case. Hippokratia; 2007 Apr;11(2):89-91
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  • Adnexal tumors of the hair follicle can be regarded as lesions that show similar differentiation to one or more portions of the hair follicle.
  • Trichoblastic carcinoma is a rare malignant adnexal tumor, which usually occurs on the scalp.
  • We report a case of a 65 years old man with a painless irregular mass of the posterior surface of the right pinna, which was slowly growing over a 5-year period.
  • He had a history of a similar lesion on the same site, which was removed 8 years before he presented to us.

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  • (PMID = 19582185.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2464267
  • [Keywords] NOTNLM ; malignant pilar tumor / pilar carcinoma / trichoblastic carcinoma
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34. Timmerman D, Ameye L, Fischerova D, Epstein E, Melis GB, Guerriero S, Van Holsbeke C, Savelli L, Fruscio R, Lissoni AA, Testa AC, Veldman J, Vergote I, Van Huffel S, Bourne T, Valentin L: Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group. BMJ; 2010;341:c6839
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  • [Title] Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group.
  • OBJECTIVES: To prospectively assess the diagnostic performance of simple ultrasound rules to predict benignity/malignancy in an adnexal mass and to test the performance of the risk of malignancy index, two logistic regression models, and subjective assessment of ultrasonic findings by an experienced ultrasound examiner in adnexal masses for which the simple rules yield an inconclusive result.
  • DESIGN: Prospective temporal and external validation of simple ultrasound rules to distinguish benign from malignant adnexal masses.
  • The rules comprised five ultrasonic features (including shape, size, solidity, and results of colour Doppler examination) to predict a malignant tumour (M features) and five to predict a benign tumour (B features).
  • If one or more M features were present in the absence of a B feature, the mass was classified as malignant.
  • If one or more B features were present in the absence of an M feature, it was classified as benign.
  • PARTICIPANTS: 1938 women with an adnexal mass examined with ultrasound by the principal investigator at each centre with a standardised research protocol.
  • Reference standard Histological classification of the excised adnexal mass as benign or malignant.
  • RESULTS: Of the 1938 patients with an adnexal mass, 1396 (72%) had benign tumours, 373 (19.2%) had primary invasive tumours, 111 (5.7%) had borderline malignant tumours, and 58 (3%) had metastatic tumours in the ovary.
  • CONCLUSIONS: The use of the simple rules has the potential to improve the management of women with adnexal masses.
  • In adnexal masses for which the rules yielded an inconclusive result, subjective assessment of ultrasonic findings by an experienced ultrasound examiner was the most accurate diagnostic test; the risk of malignancy index and the two regression models were not useful.
  • [MeSH-major] Adnexal Diseases / ultrasonography. Genital Neoplasms, Female / ultrastructure

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  • (PMID = 21156740.001).
  • [ISSN] 1756-1833
  • [Journal-full-title] BMJ (Clinical research ed.)
  • [ISO-abbreviation] BMJ
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3001703
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35. Torres A, Torres K, Paszkowski T, Staśkiewicz G, Maciejewski R, Woźniakowska E, Zaleska W: [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy]. Ginekol Pol; 2007 Oct;78(10):764-7
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  • [Title] [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy].
  • OBJECTIVES: The aim of the study was to compare serum concentrations of the TNF-alpha (TNF-alpha) in the early postoperative period in patients with benign adnexal masses operated by laparoscopy or laparotomy.
  • MATERIAL AND METHODS: The study was conducted in a group of patients aged from 20 to 52, operated due to adnexal masses.
  • CONCLUSIONS: Lower concentrations of TNF-alpha in the laparoscopy group, observed 24 hours after the operation, may reflect more favorable changes in the systemic inflammatory response after minimally invasive management of benign ovarian masses.
  • [MeSH-major] Biomarkers, Tumor / blood. Laparoscopy. Laparotomy. Ovarian Diseases / blood. Ovarian Diseases / surgery. Postoperative Period. Tumor Necrosis Factor-alpha / blood
  • [MeSH-minor] Adnexal Diseases / blood. Adnexal Diseases / surgery. Adult. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Adnexal and Skin Appendage / blood. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / surgery. Ovarian Neoplasms / blood. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18200965.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Necrosis Factor-alpha
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36. Valenzano Menada M, Fortunato T, Ferrero S, Petrera P, Fulcheri E, Bogliolo S: Massive ovarian edema: a case of over 30 cm ovarian mass in young woman. Minerva Ginecol; 2008 Aug;60(4):345-8
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  • There was no sign of systemic infection and the tumour markers are negative.
  • The adnexa weighted 1,585 g.
  • The majority of cases present with recurrent abdominal pain or a palpable adnexal mass.

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  • (PMID = 18560351.001).
  • [ISSN] 0026-4784
  • [Journal-full-title] Minerva ginecologica
  • [ISO-abbreviation] Minerva Ginecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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37. Nelson PS, Bourgeois KM, Nicotri T Jr, Chiu ES, Poole JC: Sclerosing sweat duct carcinoma in a 6-year-old African American child. Pediatr Dermatol; 2008 Jan-Feb;25(1):38-42
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  • Sclerosing sweat duct carcinoma is a rare, locally aggressive adnexal tumor that frequently occurs on the face of middle-aged adults, invades deeply, and has a propensity to recur.
  • [MeSH-major] African Americans. Carcinoma, Skin Appendage / ethnology. Carcinoma, Skin Appendage / pathology. Neoplasm Invasiveness / pathology. Sweat Gland Neoplasms / ethnology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18304151.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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38. Tan ML, Lam SL, Nadarajah S: Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. Singapore Med J; 2008 Mar;49(3):e78-81
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  • Ultrasonography showed a right adnexal mass, probably ovarian in origin, with suspicious intratumoral bleed.
  • We discuss the clinical presentation of this unusual tumour, though often asymptomatic, can rarely present with severe abdominal pain from complications like torsion with rupture, leading to massive intra-abdominal bleeding.
  • [MeSH-major] Hemorrhage / etiology. Luteoma / complications. Luteoma / diagnosis. Ovarian Neoplasms / complications. Ovarian Neoplasms / diagnosis. Pregnancy Complications. Rupture / diagnosis. Torsion Abnormality / diagnosis


39. Delfino S, Toto V, Brunetti B, Bianchi A, Baldi A, Persichetti P: Recurrent atypical eccrine spiradenoma of the forehead. In Vivo; 2008 Nov-Dec;22(6):821-3
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  • Eccrine spiradenoma is an uncommon but well recognized benign adnexal tumour of the eccrine sweat glands.
  • The differential diagnosis of this tumour, as well as its possible malignant transformation, is discussed.

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  • (PMID = 19181014.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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40. Nezhat FR, Ezzati M, Chuang L, Shamshirsaz AA, Rahaman J, Gretz H: Laparoscopic management of early ovarian and fallopian tube cancers: surgical and survival outcome. Am J Obstet Gynecol; 2009 Jan;200(1):83.e1-6
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  • STUDY DESIGN: Case series conducted at the University Hospital with 36 patients who had presumed early-stage adnexal cancers.
  • RESULTS: Cases included 20 invasive epithelial tumors, 11 borderline tumors, and 5 nonepithelial tumors.
  • CONCLUSION: This represents 1 of the largest series and longest follow-ups of laparoscopic staging for early-stage adnexal tumors.

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  • (PMID = 19019337.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Târcoveanu E, Dimofte G, Niculescu D, Vasilescu A, Moldovanu R, Ferariu D, Marcovici I: Ovarian fibroma in the era of laparoscopic surgery: a general surgeon's experience. Acta Chir Belg; 2007 Nov-Dec;107(6):664-9
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  • The ovarian fibroma is a rare benign tumor originating from the connective tissue of the ovarian cortex.
  • Only four cases required emergency operations due to either tumors or adnexal torsion.
  • Surgical treatment consisted of five ovarectomies, three adnexal resections and five total hysterectomies with bilateral salpingo-oophorectomy.

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  • (PMID = 18274181.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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42. Liu WM, Wang PH, Chia CC: A feasible laparoscopic surgery technique for complex adnexal tumors. Taiwan J Obstet Gynecol; 2007 Jun;46(2):185-6; author reply 186
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  • [Title] A feasible laparoscopic surgery technique for complex adnexal tumors.
  • [MeSH-major] Adnexa Uteri / surgery. Laparoscopy / methods. Ovarian Neoplasms / surgery. Uterine Neoplasms / surgery

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  • [CommentOn] Taiwan J Obstet Gynecol. 2007 Mar;46(1):83-4 [17389199.001]
  • (PMID = 17638632.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] China
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43. Park HJ, Lee DY, Lee JH, Yang JM, Lee ES, Kim WS: The treatment of syringomas by CO(2) laser using a multiple-drilling method. Dermatol Surg; 2007 Mar;33(3):310-3
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  • BACKGROUND: Syringomas are relatively common benign adnexal tumors, predominantly developing in middle-aged women.
  • OBJECTIVES: The objective of this study was to determine the effectiveness of a multiple-drilling method in the treatment of syringomas.

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  • (PMID = 17338688.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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44. Karaca M, Sevinc A, Aydin A, Gocmen A, Buyukberber S, Camci C, Sari I: Female adnexal tumor of probable Wolffian origin diagnosed during the staging evaluation of extranodal diffuse large B-cell lymphoma. Leuk Lymphoma; 2005 Jun;46(6):929-33
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  • [Title] Female adnexal tumor of probable Wolffian origin diagnosed during the staging evaluation of extranodal diffuse large B-cell lymphoma.
  • Female adnexal tumor of probable Wolffian origin (FATPWO) is a rare neoplasm arising within the leaves of broad ligament or hanging from it or a fallopian tube.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis. Wolffian Ducts / pathology

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  • (PMID = 16019541.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Topuz S, Saygili H, Akhan S, Yavuz E, Turfanda A, Berkman S: Differentiation of benign and malignant adnexal masses: value of a morphologic scoring system. Eur J Gynaecol Oncol; 2005;26(2):209-12
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  • [Title] Differentiation of benign and malignant adnexal masses: value of a morphologic scoring system.
  • OBJECTIVE: The purpose of this study was to assess the value of conventional gray-scale ultrasonography, based on a morphologic scoring system, in the differential diagnosis of malignant and benign adnexal tumors.
  • MATERIAL AND METHODS: A total of 58 adnexal masses in 51 patients were classified prospectively as suggestive of malignant or benign, on the basis of gray-scale ultrasonographic morphology.
  • RESULTS: Histopathology of 42 masses was found to be benign and 16 masses were found to be malignant.
  • On gray-scale analysis 15 of 16 malignant masses were classified as suggestive of malignant and 37 of 42 benign masses were classified as suggestive of benign.
  • However further investigations about the assessment of adnexal masses with ultrasonography are needed
  • [MeSH-major] Adnexal Diseases / ultrasonography. Neoplasms / ultrasonography

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  • (PMID = 15857033.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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46. Lesin J, Forko-Ilić J, Plavec A, Planinić P: Management of Wolffian duct tumor recurrence without chemotherapy. Arch Gynecol Obstet; 2009 Nov;280(5):855-7
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  • [Title] Management of Wolffian duct tumor recurrence without chemotherapy.
  • BACKGROUND: A female adnexal tumor of probable Wolffian origin (FATWO) is a rare neoplasm which is considered to have a low malignant potential.
  • CASE: In 2006, a 60-year-old patient was admitted to hospital with solid tumor on the vaginal cuff confirmed by abdominal/pelvic CT, 6 years after her first FATWO was diagnosed and hysterectomy, bilateral adnexectomy, and omentectomia were done.
  • Pelvic washings, lysis of adhesions, and excision of tumor mass were performed.
  • Pathologic examination revealed malignant epithelial neoplasm of Wolffian origin with morphologic features similar to those of the patient's prior tumor.

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  • (PMID = 19288122.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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47. Silva CS, Souza MB, Lima KA, de Almeida MA, Criado PR: [Generalized eruptive syringoma: case report]. Dermatol Online J; 2009;15(2):7
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  • [Transliterated title] Siringoma eruptivo disseminado: Relato de caso.
  • Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts.
  • Clinically, they usually appear as small yellow or skin-colored papules ranging from 1-3 mm in diameter on the lower eyelids.
  • [MeSH-major] Skin / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19336024.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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48. Craver R, Ward K, Heinrich S: Congenital subcutaneous dendritic cell rich lymphoepithelial hamartoma. Fetal Pediatr Pathol; 2005 Jul-Oct;24(4-5):255-65
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  • We present the clinical, radiologic, histologic, immunohistochemical, and ultrastructural characteristics of a congenital pretibial subcutaneous lesion composed of a mixture of T and B cells, epithelial cells, and dendritic cells, probably representing a hamartoma.
  • The prominent dendritic component of this lesion, demonstrated immunohistochemically and ultrastructurally, separates the lesion from cutaneous lymphadenoma and other adnexal tumors.
  • [MeSH-major] Dendritic Cells / pathology. Hamartoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] B-Lymphocytes / metabolism. B-Lymphocytes / pathology. B-Lymphocytes / ultrastructure. Cysts / pathology. Diagnosis, Differential. Epithelial Cells / metabolism. Epithelial Cells / pathology. Epithelial Cells / ultrastructure. Humans. Immunohistochemistry. Infant. Lipoma / pathology. Male. Microscopy, Electron, Transmission. Neoplasms, Adnexal and Skin Appendage / pathology. T-Lymphocytes / metabolism. T-Lymphocytes / pathology. T-Lymphocytes / ultrastructure

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  • (PMID = 16396831.001).
  • [ISSN] 1551-3815
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Sala E, Rockall A, Rangarajan D, Kubik-Huch RA: The role of dynamic contrast-enhanced and diffusion weighted magnetic resonance imaging in the female pelvis. Eur J Radiol; 2010 Dec;76(3):367-85
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  • This is mainly due to the limitations of morphologic imaging, particularly in lesion characterization, accurate lymph node staging, assessment of tumour response and inability to differentiate post-treatment changes from tumour recurrence.
  • It also helps differentiate tumour recurrence from radiation fibrosis in patients with cervical cancer.
  • DCE-MRI improves characterization of cystic adnexal lesions and detection of small peritoneal implants in patients with ovarian cancer.

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20810230.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
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50. Cortés-Charry R, Figueira LM, García-Barriola V, Gomez C, Garcia I, Santiago C: Gestational trophoblastic disease in ectopic pregnancy: A case series. J Reprod Med; 2006 Oct;51(10):760-3
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  • OBJECTIVE: To describe 6 cases of gestational trophoblastic disease (GTD) in ectopic pregnancy admitted to Hospital Universitario de Caracas (HUC).
  • Ultrasound revealed an adnexal tumor in 5 cases; this tumor and hemoperitoneum (6 cases) were the most frequent surgical findings.


51. Yazbek J, Raju SK, Ben-Nagi J, Holland TK, Hillaby K, Jurkovic D: Effect of quality of gynaecological ultrasonography on management of patients with suspected ovarian cancer: a randomised controlled trial. Lancet Oncol; 2008 Feb;9(2):124-31
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  • BACKGROUND: The diagnostic accuracy of ultrasonography for differentiating between benign and malignant adnexal masses is proportional to the expertise of the operator.
  • However, we do not know whether improved diagnostic accuracy will affect the management of these tumours.
  • METHODS: 165 patients who were referred to the regional gynaecological cancer centre at Guy's and St Thomas' NHS Foundation Trust (London, UK), between June 7, 2004, and April 23, 2006, with suspected adnexal tumours met the inclusion criteria.


52. Roussel A, Thomassin-Naggara I, Darai E, Marsault C, Bazot M: [Value of diffusion-weighted imaging in the evaluation of adnexal tumors]. J Radiol; 2009 May;90(5 Pt 1):589-96
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  • [Title] [Value of diffusion-weighted imaging in the evaluation of adnexal tumors].
  • [Transliterated title] Evaluation de la séquence de diffusion pour l'étude des tumeurs annexielles.
  • PURPOSE: To determine the value of diffusion-weighted imaging (DWI) in the evaluation of adnexal tumors, especially to distinguish between malignant and benign tumors.
  • Fifty-four patients with pelvic tumors (32 malignant and 22 benign) were referred for MRI of the pelvis.
  • The signal of solid and cystic tumor components was evaluated on T2W and b=1000 DWI, and ADC values were obtained.
  • RESULTS: T2W hypointensity or absence of hyperintense signal on b=1000 DWI sequences was suggestive of a benign tumor.
  • ADC values did not appear to discriminate between malignant and benign tumors.
  • Also, the signal intensity of cystic tumor components on DWI sequences was not helpful to distinguish between malignant and benign tumor.
  • CONCLUSION: The evaluation of solid tumor components on DWI appears to be helpful for adnexal tumor characterization.
  • [MeSH-major] Adnexal Diseases / diagnosis. Diffusion Magnetic Resonance Imaging / methods. Genital Neoplasms, Female / diagnosis. Image Enhancement. Image Processing, Computer-Assisted
  • [MeSH-minor] Adnexa Uteri / pathology. Adnexa Uteri / surgery. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Middle Aged. Sensitivity and Specificity. Young Adult

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  • (PMID = 19503047.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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53. Jamalipour M, Heidarpour M, Rajabi P: Generalized eruptive syringomas. Indian J Dermatol; 2009;54(1):65-7
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  • Generalized eruptive syringoma is a rare clinical presentation of a benign adnexal tumor that derives from the intraepidermal portion of the eccrine sweat ducts.
  • Treatment of this benign condition is cosmetic only.
  • A case of a 28-year-old female with an eight-year history of eruptive syringoma is presented.

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  • (PMID = 20049275.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2800876
  • [Keywords] NOTNLM ; Generalized eruptive syringoma / eccrine ducts / papules
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54. Parma P, Dall'Oglio B, Samuelli A, Bondavalli C, Bellomi A: [Laparoscopic removal of voluminous right seminal vesicle neoplasm]. Urologia; 2010 Oct-Dec;77 Suppl 17:46-9
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  • INTRODUCTION: We present the case of a male adnexal tumor of probable Wolffian origin occurred to the right seminal vesicle of a 47-year-old man.
  • RESULTS: The right seminal vesicle, along with the tumor and the right vas deferens, were excised and clear margins were ensured by frozen section.
  • The histologic examination demonstrated a male adnexal tumor of probable Wolffian origin, which is a rare low-grade malignant neoplasm that has been previously described in the broad ligament, ovaries and retroperitoneum of females.
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adnexal Diseases / complications. Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Adnexal Diseases / surgery. Biopsy. Diagnosis, Differential. Hemospermia / etiology. Humans. Male. Middle Aged. Tomography, X-Ray Computed. Vas Deferens / surgery

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  • (PMID = 21308675.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Wolffian tumor
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55. Zaraa I, Zeglaoui F, Fazaa B, Ezzine N, Elfekih N, Zermani R, Ben Jilani S, Kamoun MR: [Brooke-Spiegler syndrome]. Tunis Med; 2006 Sep;84(9):578-80
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  • [Transliterated title] Syndrome de brooke-Spiegler.
  • Brooke Spiegler syndrome is a rare genodermatosis characterized by an association of multiple trichoepitheliomas and cylindromas, sometimes accompanied by other adnexal tumors (spiradenoma, mila), we report two family cases of Brooke Spiegler syndrome.
  • No neoplastic tumor was identified.
  • A co-existence of adnexal tumors was found in the other members of the family.
  • Brooke Spiegler syndrome is an autosomial dominant disease with variable penetrance, it's characterized by a family history of trichoepitheliomas, with other adnexal tumors.
  • Brooke Spiegler syndrome is usually a benign disease, but patients with this syndrome should be explored for malignancy.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics

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  • (PMID = 17263207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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56. Valentin L: Imaging in gynecology. Best Pract Res Clin Obstet Gynaecol; 2006 Dec;20(6):881-906
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  • This chapter summarizes the diagnostic performance (sensitivity, specificity, positive and negative likelihood ratios) of ultrasound, computer tomography, and magnetic resonance imaging in the diagnosis of various gynecological diseases and tumors.
  • Imaging in infertility, in the diagnosis of Mullerian duct anomalies and in gynecological oncology (staging of gynecological cancers, diagnosis of recurrence of gynecological cancer, diagnosis of trophoblastic tumors) is not dealt with.
  • Ultrasound is the first-line imaging method for discrimination between viable intrauterine pregnancy, miscarriage and tubal pregnancy in women with bleeding and/or pain in early pregnancy, for discrimination between benign and malignant adnexal masses and for making a specific diagnosis in adnexal tumors (e.g. dermoid cyst, endometrioma, hemorrhagic corpus luteum, etc.
  • [MeSH-minor] Abortion, Spontaneous / ultrasonography. Adnexal Diseases / ultrasonography. Female. Humans. Magnetic Resonance Imaging / methods. Pelvic Pain / ultrasonography. Pregnancy. Pregnancy Trimester, First. Pregnancy, Ectopic / ultrasonography. Sensitivity and Specificity. Tomography, X-Ray Computed / methods. Uterine Hemorrhage / ultrasonography. Uterine Neoplasms / diagnosis

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  • (PMID = 16904942.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 172
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57. Hong SK, Lee HJ, Cho SH, Seo JK, Lee D, Sung HS: Syringomas Treated by Intralesional Insulated Needles without Epidermal Damage. Ann Dermatol; 2010 Aug;22(3):367-9
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  • Syringoma is a benign adnexal tumor derived from intradermal eccrine ducts; it predominantly occurs in women at puberty or later in life.
  • Although syringoma is a common benign neoplasm, there have been no effective therapies for its removal.

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  • [Cites] Dermatol Surg. 2007 Mar;33(3):310-3 [17338688.001]
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  • (PMID = 20711282.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917699
  • [Keywords] NOTNLM ; Insulated needle / Syringoma
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58. Cribier B: [Accurate diagnosis of adnexal tumours can be a matter of life or death]. Ann Dermatol Venereol; 2009 Feb;136(2):125-32
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  • [Title] [Accurate diagnosis of adnexal tumours can be a matter of life or death].
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 19232249.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 58
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59. Arias D, Castellano VM, Córdoba S, Miñano R, Martínez D, Borbujo JM: [Atypical presentation of syringocystoadenoma papilliferum]. Actas Dermosifiliogr; 2006 Dec;97(10):647-9
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  • [Transliterated title] Siringocistoadenoma papilífero de presentación atípica.
  • Syringocystoadenoma papilliferum is benign adnexal tumor derived from the sweat glands that is located in the head and neck in 70-80% of patients, and commonly presents as a papule or a solitary nodule.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Neoplasms, Second Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17173827.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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60. Takeda A, Sakai K, Mitsui T, Nakamura H: Management of large cystic adnexal tumor by gasless laparoscopic-assisted surgery with wound retractor. J Minim Invasive Gynecol; 2007 Sep-Oct;14(5):644-50
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  • [Title] Management of large cystic adnexal tumor by gasless laparoscopic-assisted surgery with wound retractor.
  • We used a retrospective analysis to evaluate the efficacy of a wound retractor used in gasless laparoscopic-assisted surgery by the subcutaneous abdominal wall-lift method for the management of large cystic adnexal tumors.
  • In the department of gynecology at a general hospital, 39 patients with large cystic adnexal tumors with an excised tissue weight including cystic contents exceeding 1000 g were treated by gasless laparoscopic-assisted surgery with a wound retractor from January 2001 through December 2006.
  • Intervention was with a gasless laparoscopic-assisted adnexal surgery with a wound retractor.
  • Histopathologic diagnosis of the excised tumor was mucinous cystadenoma, 18 cases; serous cystadenoma, 8 cases; mucinous cystadenocarcinoma of low-grade malignancy, 5 cases; dermoid cyst, 4 cases; paraovarian cyst, 2 cases; endometriotic cyst, 1 case; and clear cell adenocarcinoma, 1 case.
  • Bilateral adnexal tumors were noted in 3 cases.
  • We determined that gasless laparoscopic-assisted adnexal surgery with a wound retractor is an effective, minimally invasive procedure to treat large cystic adnexal tumors.

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  • (PMID = 17848329.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Leibovitch I, Huilgol SC, Selva D, Paver R, Richards S: Cutaneous lip tumours treated with Mohs micrographic surgery: clinical features and surgical outcome. Br J Dermatol; 2005 Dec;153(6):1147-52
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  • [Title] Cutaneous lip tumours treated with Mohs micrographic surgery: clinical features and surgical outcome.
  • BACKGROUND: The Australian Mohs micrographic surgery (MMS) database was initiated in 1993 by the Skin and Cancer Foundation Australia (SCFA) with the aim of collecting prospective data, and involved all Mohs surgeons in the country.
  • OBJECTIVES: To present a large series of patients with cutaneous lip tumours treated with MMS in Australia between 1993 and 2002.
  • METHODS: This prospective multicentre case series included all patients with cutaneous lip tumours who were monitored by the SCFA.
  • The main outcome measures were patient demographics, reason for referral, duration of tumour, site, preoperative tumour size and postoperative defect size, recurrences prior to MMS, histological subtypes, perineural invasion and 5-year recurrence after MMS.
  • Basal cell carcinoma (BCC) was diagnosed in 82.3%, squamous cell carcinoma (SCC) in 16.5%, Bowen's disease (BD) in 0.7% and microcystic adnexal carcinoma (MAC) in 0.5% of cases.
  • Most upper lip tumours occurred in women (75.4%), whereas most lower lip tumours occurred in men (73.6%).
  • SCC was associated with a larger tumour and postoperative defect size compared with the other tumours.
  • CONCLUSIONS: BCC was the most common cutaneous lip tumour managed by MMS, and was significantly more common on the upper lip and in women.

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  • (PMID = 16307650.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] England
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62. Cabo H, Pedrini F, Cohen Sabban E: Dermoscopy of cylindroma. Dermatol Res Pract; 2010;2010
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  • Background. Dermoscopy provides additional criteria for the diagnosis of nonpigmented skin lesions. Case Report.
  • Conclusion. Our case suggests that cylindromas may be added to the list of adnexal tumors mimicking BCC.

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  • (PMID = 20862372.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2938454
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63. Zaballos P, Llambrich A, Ara M, Olazarán Z, Malvehy J, Puig S: Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patients. Br J Dermatol; 2006 Feb;154(2):244-50
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  • However, the differentiation of dermatofibroma from other cutaneous tumours is difficult in some instances, primarily in atypical cases and rare variants.
  • The clinical differential diagnosis of haemosiderotic or aneurysmal dermatofibroma must include melanoma and other melanocytic tumours, vascular neoplasms, adnexal tumours and nonspecific cysts.
  • Dermoscopy improves the diagnostic accuracy in pigmented and nonpigmented skin lesions.
  • [MeSH-major] Dermoscopy. Hemosiderin / analysis. Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Br J Dermatol. 2007 Jan;156(1):199-200 [17199605.001]
  • (PMID = 16433792.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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64. Kim MY, Rha SE, Oh SN, Lee YJ, Jung ES, Byun JY: Case report: Ovarian cavernous haemangioma presenting as a heavily calcified adnexal mass. Br J Radiol; 2008 Nov;81(971):e269-71
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  • [Title] Case report: Ovarian cavernous haemangioma presenting as a heavily calcified adnexal mass.
  • Haemangioma is an extremely rare tumour of the ovary.
  • We describe the CT and MRI findings of a heavily calcified ovarian haemangioma in a 69-year-old woman presenting with adnexal torsion.
  • MR images also demonstrated a beak-like protrusion from the adnexal mass, representing the adnexal torsion.
  • This is the first case report of a heavily calcified ovarian haemangioma in the English literature.
  • Although rare, ovarian haemangioma should be included in the differential diagnosis of a heavily calcified adnexal mass.
  • [MeSH-minor] Adnexal Diseases / diagnosis. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 18941040.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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65. Sing P, Mushtaq D, Verma N, Mahajan NC: Pelvic hydatidosis mimicking a malignant multicystic ovarian tumor. Korean J Parasitol; 2010 Sep;48(3):263-5
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  • [Title] Pelvic hydatidosis mimicking a malignant multicystic ovarian tumor.
  • We report here 1 such case of primary pelvic hydatidosis mimicking a malignant multicystic ovarian tumor where there was no evidence of involvement of the liver or spleen.
  • Our patient, a 27-year-old female, was detected to have a large right cystic adnexal mass on per vaginal examination which was confirmed by ultrasonography.
  • Her biochemical parameters were normal and CA-125 levels, though mildly raised, were below the cut off point.
  • On cut sections both large cysts revealed numerous daughter cysts.

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  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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  • [Keywords] NOTNLM ; Echinococcus granulosus / daughter cysts / hydatidosis / multicystic ovarian tumour
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66. Coupland SE, Hellmich M, Auw-Haedrich C, Lee WR, Anagnostopoulos I, Stein H: Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases. Br J Ophthalmol; 2005 Mar;89(3):352-9
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  • [Title] Plasmacellular differentiation in extranodal marginal zone B cell lymphomas of the ocular adnexa: an analysis of the neoplastic plasma cell phenotype and its prognostic significance in 136 cases.
  • AIM: To determine (a) the expression of plasma cell related antigens in extranodal marginal zone B cell lymphomas (EMZL) of the ocular adnexa; and (b) the prognostic value of plasmacellular differentiation in these tumours.
  • METHODS: A consecutive case series of 136 ocular adnexal EMZL obtained from three ocular pathology centres over 20 years was analysed retrospectively.
  • The end points considered for statistical analysis were development of local tumour recurrence, development of systemic disease, and lymphoma related death.
  • RESULTS: 57 (42%) of the 136 ocular adnexal EMZL showed a plasmacellular differentiation; 45 of these plasmacytoid cases were primary tumours.
  • In contrast with most admixed normal plasma cells, which displayed co-expression of MUM1/IRF4, Vs38c, CD38, CD138, and CBP, the plasmacellular differentiated EMZL tumour cells demonstrated co-expression of all five plasma cell related antigens in only six of 57 (11%) plasmacellular differentiated ocular adnexal EMZL.
  • Although the association of plasmacellular differentiation in primary ocular adnexal EMZL and disseminated disease was statistically significant on univariate analysis (p = 0.042), this was weaker on multivariate analysis.
  • CONCLUSION: Plasmacellular differentiated tumour cells in EMZL demonstrate an aberrant immune profile for plasma cell related antigens when compared with normal plasma cells.
  • On multivariate analysis, plasmacellular differentiation in ocular adnexal EMZL was not significantly associated with local recurrence, the development of systemic disease, or with lymphoma related death.
  • [MeSH-major] Autoantigens / analysis. Biomarkers, Tumor / analysis. Eye Neoplasms / immunology. Lymphoma, B-Cell / immunology. Plasma Cells / immunology

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  • (PMID = 15722318.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD; 0 / Autoantigens; 0 / Biomarkers, Tumor; 0 / CREBBP protein, human; 0 / DNA-Binding Proteins; 0 / Interferon Regulatory Factors; 0 / Membrane Glycoproteins; 0 / Nuclear Proteins; 0 / Proteoglycans; 0 / SDC1 protein, human; 0 / Syndecan-1; 0 / Syndecans; 0 / Trans-Activators; 0 / Transcription Factors; 0 / VS38 monoclonal antibody; 0 / interferon regulatory factor-4; EC 2.3.1.48 / CREB-Binding Protein; EC 3.2.2.5 / ADP-ribosyl Cyclase; EC 3.2.2.5 / Antigens, CD38; EC 3.2.2.5 / CD38 protein, human
  • [Other-IDs] NLM/ PMC1772544
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67. Marret H, Wagner N, Ouldamer L, Jacquet A, Body G: [Pelvic actinomycosis: just think of it]. Gynecol Obstet Fertil; 2010 May;38(5):307-12
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  • OBJECTIVES: Pelvic actinomycosis is a rare disease that can be diagnosed before, during or after surgical treatment of a suspected ovarian tumor, a suspected bowel obstruction, or acute peritonitis.
  • If there is no fever in association with an atypical adnexal tumor, frozen section should be obtained during surgery to rule out the diagnosis of actinomycosis.

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20430667.001).
  • [ISSN] 1769-6682
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Penicillins
  • [Number-of-references] 36
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68. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
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  • Familial cylindromatosis (Brooke-Spiegler syndrome) is a rare autosomal dominant inherited disease characterized by the development of adnexal tumors, mostly cylindromas, but also trichoepitheliomas and spiradenomas.
  • Malignant tumors may occur, usually with the features of a cylindrocarcinoma.
  • The authors describe the case of a 75-year-old woman with the Brooke-Spiegler syndrome who presented with multiple nodules of the scalp, face, and trunk.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • The authors discuss the morphogenesis of the folliculosebaceous-apocrine unit from which the tumors in this syndrome derive, and the pivotal role of mesenchymal cells in determining the process.
  • Since the Brooke-Spiegler syndrome is characterized by a germline mutation in the CYLD oncosuppressor gene, a biphasic tumor in this setting may represent a true carcinosarcoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

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  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10
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  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • They may be clinically confused with other cutaneous tumors.
  • The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16-year period.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • RESULTS: Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period.
  • Only two cases had a clinical diagnosis of adnexal tumor.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • Tumours of hair follicle were 4 (7.7%) and included trichoepithelioma, characterized microscopically by multiple horn cysts and epithelial tracts connecting abortive pilar structures and a trichofolliculoma.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • Malignant adnexal tumors are uncommon in our setting.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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70. Hu SC, Lin CL, Tsai KB, Chen GS, Chin YY, Lin CT, Lan CC: Trichoblastoma-like tumour with follicular, matrical and sebaceous differentiation: involvement of hair follicle stem cells? Acta Derm Venereol; 2010 Jul;90(4):436-7
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  • [Title] Trichoblastoma-like tumour with follicular, matrical and sebaceous differentiation: involvement of hair follicle stem cells?
  • [MeSH-major] Cell Differentiation. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplastic Stem Cells / pathology. Scalp. Sebaceous Glands / pathology. Skin Neoplasms / pathology

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  • (PMID = 20574623.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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71. Seirafi HH, Akhyani M, Naraghi ZS, Mansoori P, Dehkordi HS, Taheri A, Ehsani AH, Kavusi S, Farnaghi F: Eruptive syringomas. Dermatol Online J; 2005;11(2):13
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  • Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts.

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  • (PMID = 16150221.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Novak NP, Kaić G, Tomasović-Loncarić C, Zic R, Skoro M, Ostović KT: Fine-needle aspiration cytology of apocrine hidradenoma. Coll Antropol; 2010 Jun;34(2):671-4
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  • An apocrine hidradenoma is a benign adnexal neoplasm, usually covered by intact skin, but may show superficial ulceration and serous discharge.
  • This feature is raising the possibility of malignancy as it was in our case of macroscopically suspicious tumour.
  • We described cytomorphologic features of cutaneous nodule that might be a lead to the cytologic diagnosis of hidradenoma, but primary or secondary malignant tumour has been ruled out first.
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 20698151.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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73. Zimmer M, Pomorski M, Wiatrowski A, Fuchs T, Myszczyszyn G: Application of endoscopy in pediatric and adolescent gynecology. Neuro Endocrinol Lett; 2008 Feb;29(1):11-5
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  • The laparoscopy is becoming a more and more popular method in the treatment of adnexal tumors in children, due to its little invasiveness, quick recovery and less severe pain complaints after the surgery.
  • They should be considered diagnostics and treatment of choice in the pathology of vulva, vagina, developmental anomalies of sex organ and adnexal tumors in patients of the developmental age.

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  • (PMID = 18283270.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Sweden
  • [Number-of-references] 23
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74. McCluggage WG: Recent developments in vulvovaginal pathology. Histopathology; 2009 Jan;54(2):156-73
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  • Aggressive angiomyxoma is almost invariably positive with oestrogen and progesterone receptors, and there have been several reports of a dramatic reduction in size following gonadotropin releasing hormone agonist therapy.
  • Gastrointestinal stromal tumours have been described as primary neoplasms in the vagina, and rectovaginal septum and extragastrointestinal stromal tumour should be added to the differential diagnosis of a vulvovaginal mesenchymal lesion.
  • There have been new developments regarding Paget's disease of the vulva with the identification of markers that are useful in diagnosis and evidence that the neoplastic cells represent a proliferation of adnexal stem cells residing in sebaceous units.

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  • (PMID = 18637148.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 138
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75. Chia CC, Huang SC: A feasible laparoscopic surgery technique for complex adnexal tumors. Taiwan J Obstet Gynecol; 2007 Mar;46(1):83-4
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  • [Title] A feasible laparoscopic surgery technique for complex adnexal tumors.
  • [MeSH-major] Adnexal Diseases / surgery. Cysts / surgery. Genital Neoplasms, Female / surgery. Laparoscopy / methods

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  • [CommentIn] Taiwan J Obstet Gynecol. 2007 Jun;46(2):185-6; author reply 186 [17638632.001]
  • (PMID = 17389199.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] China
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76. Plaza JA, Ortega PF, Bengana C, Stockman DL, Suster S: Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases. Am J Dermatopathol; 2010 Oct;32(7):683-7
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  • When the morphologic distinction between basal cell carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two neoplasms from each other.
  • Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous neoplasms, such as adnexal tumors, squamous cell carcinomas, etc.
  • A total of 49 cutaneous tumors, including 22 cases of trichoepitheliomas and 27 cases of BCC were examined.
  • This data suggests that D2-40 expression could be a useful potential marker to distinguish BCCs from trichoepitheliomas, especially when there is a high index of histologic suspicion for either of these two tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Membrane Glycoproteins / biosynthesis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20559122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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77. Lee CY, Tseng CC, Wang CB, Lin YH, Chen CH, Wun TH, Sun YL, Tseng CJ: A new quantitative method to evaluate adnexal tumors. Taiwan J Obstet Gynecol; 2010 Mar;49(1):45-9
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  • [Title] A new quantitative method to evaluate adnexal tumors.
  • We chose quantitative tumor density and standard deviation on sonographic images as the new diagnostic parameters.
  • Analysis of variance and Scheffé post hoc test were analyzed to compare the mean tumor density of the endometriomas and follicular cysts.
  • The receiver operating characteristic curve was plotted to choose the cutoff value of the endometrioma tumor density with the best sensitivity and specificity.
  • RESULTS: There was a significant difference when the tumor density of the follicular cyst and endometrioma groups was compared using the vaginal, abdominal or endovaginal approach (p < 0.001).
  • With endovaginal ultrasonography examination, the best cutoff value of tumor density is 28 and the sensitivity and specificity are 64% and 100%, respectively.
  • CONCLUSION: The use of quantitative tumor density and standard deviation on sonographic images is a potential new diagnostic tool in the assessment of endometriomas and follicular cysts.
  • [MeSH-major] Adnexal Diseases / diagnosis. Endometriosis / diagnosis. Follicular Cyst / diagnosis. Ultrasonography / methods

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  • (PMID = 20466292.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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78. Sariya D, Ruth K, Adams-McDonnell R, Cusack C, Xu X, Elenitsas R, Seykora J, Pasha T, Zhang P, Baldassano M, Lessin SR, Wu H: Clinicopathologic correlation of cutaneous metastases: experience from a cancer center. Arch Dermatol; 2007 May;143(5):613-20
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  • OBJECTIVE: To analyze the clinical, histopathologic, and immunohistochemical characteristics of skin metastases.
  • PATIENTS: Fifty-one patients (21 men and 30 women) with biopsy-proven skin metastases and correlative clinical data.
  • INTERVENTIONS: Four dermatopathologists reviewed a random mixture of metastases and primary skin tumors.
  • Immunohistochemical studies for 12 markers were performed on the metastases, with skin adnexal tumors as controls.
  • RESULTS: Eighty-six percent (43 of 50) of the patients had known stage IV cancer, and skin metastasis was the presenting sign in 12% (6 of 50).
  • Metastases from small cell carcinomas and sarcomas were histologically misinterpreted as primary skin tumors.
  • Immunohistochemical analysis using a panel including p63, B72.3, calretinin, and CK5/6 differentiated metastatic carcinoma from primary skin adnexal tumors.
  • CONCLUSIONS: Cutaneous metastases can have variable clinical appearances and can mimic benign skin lesions.
  • [MeSH-major] Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cancer Care Facilities. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 17515511.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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79. Bhadani PP, Sen R, Bhadani UK, Karki S, Agarwal S: Is fine needle aspiration cytology (FNAC) useful in skin adnexal masses? A study on 5 cases of pilomatixoma. Indian J Pathol Microbiol; 2007 Apr;50(2):411-4
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  • [Title] Is fine needle aspiration cytology (FNAC) useful in skin adnexal masses? A study on 5 cases of pilomatixoma.
  • Superficial cutaneous/subcutaneous nodules, caused by a variety of inflammatory, benign and malignant pathology of diverse origin, are tempting lesion for fine needle aspiration cytology (FNAC).
  • Amongst these, adnexal tumor show considerable overlap, both in clinical manifestation as well as in histopathology.
  • Other cases were diagnosed as epidermal inclusion cyst with the differential diagnosis of well differentiated squamous cell carcinoma and skin appendageal tumor of undetermined origin in one case each.
  • [MeSH-major] Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17883095.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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80. Kondoh A, Akasaka E, Yamamoto K, Mizutani K, Iwashita K, Umezawa Y, Ohta Y, Matsuyama T, Ozawa A: A case of implantation dermatosis that formed a tumor. J Dermatol; 2006 Feb;33(2):122-7
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  • [Title] A case of implantation dermatosis that formed a tumor.
  • A 51-year-old man visited our hospital complaining of a tumor located above his lip.
  • The lesion turned into a tumor and gradually enlarged.
  • The tumor was well circumscribed, smooth and covered with reddish, partially milk-white skin.
  • During surgery to remove the tumor, a piece of a chopstick was found in the subcutaneous tissue, and a diagnosis of implantation dermatosis (ID) was made.
  • On histology, the tumor appeared as an abscess that had increased fibroblasts, small vessels and a large number of neutrophils.
  • In the Japanese published work, we found 86 cases of ID; three were similar to our case and had been clinically diagnosed as adnexal tumors.
  • [MeSH-major] Foreign Bodies / complications. Foreign-Body Reaction / etiology. Foreign-Body Reaction / pathology. Skin. Skin Diseases / etiology

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  • (PMID = 16556281.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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81. Hyun DN, Won JH, Park JS, Chung H: A Case of Steatocystoma Simplex Involving the Scalp. Ann Dermatol; 2008 Dec;20(4):230-2
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  • Steatocystoma is a benign adnexal tumor originating from the pilosebaceous duct junction which can be classified into two groups (steatocystoma simplex and steatocystoma multiplex).
  • A 49-year-old man presented for evaluation and treatment of a solitary papule on the right parietal scalp which had persisted for a period of 1 year.

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  • (PMID = 27303199.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4903986
  • [Keywords] NOTNLM ; Scalp / Steatocystoma simplex
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82. Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R: Squamoid eccrine ductal carcinoma: a case report and review of the literature. Am J Dermatopathol; 2010 May;32(3):287-92
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  • Eccrine ductal carcinoma is a rare adnexal tumor.
  • This neoplasm is deeply infiltrative and may provide a diagnostic challenge in superficial shave biopsies of skin.
  • We present a case of SEDC in an immunocompromised patient, who, after an initial shave biopsy for diagnostic purposes, underwent a complete excision of his tumor by Mohs micrographic surgery.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunocompromised Host. Male. Middle Aged. Mohs Surgery

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  • (PMID = 20010402.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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83. Obaidat NA, Alsaad KO, Ghazarian D: Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol; 2007 Feb;60(2):145-59
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  • [Title] Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands.
  • Tumours of cutaneous sweat glands are uncommon, with a wide histological spectrum, complex classification and many different terms often used to describe the same tumour.
  • In addition to the eccrine and apocrine glands, two other skin sweat glands have recently been described: the apoeccrine and the mammary-like glands of the anogenital area.
  • In this review (the second of two articles on skin adnexal neoplasms), common as well as important benign and malignant lesions of cutaneous sweat glands are described, and a summary for differentiating primary adnexal neoplasms from metastatic carcinoma is outlined, striving to maintain a common and acceptable terminology in this complex subject.
  • Composite/mixed adnexal tumours are also discussed briefly.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Sweat Gland / pathology. Carcinoma, Skin Appendage / pathology. Humans. Syringoma / pathology

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  • (PMID = 16882695.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 110
  • [Other-IDs] NLM/ PMC1860616
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84. Katona TM, Billings SD, Montironi R, Lopez-Beltran A, Cheng L: Expression of OCT4 transcription factor in cutaneous neoplasia. Appl Immunohistochem Mol Morphol; 2007 Dec;15(4):359-62
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  • We have examined a series of basal cell carcinomas and adnexal tumors of related histogenesis, in an effort to corroborate the above findings and to assess for expression of OCT4 protein in neoplasia of the infundibulo-apocrine-sebaceous unit.
  • We analyzed OCT4 expression in 115 cutaneous specimens including 26 basal cell carcinomas, 12 benign follicular tumors (10 trichoepitheliomas and 2 trichoblastomas), 10 benign apocrine tumors, 12 sebaceous hyperplasia lesions, 10 sebaceous adenomas, 4 sebaceous carcinomas, 13 nevi sebacei of Jadassohn, 8 squamous cell carcinomas (including one spindle-cell squamous cell carcinoma), 8 compound melanocytic nevi, 5 Merkel cell carcinomas, 3 pilar cysts, 1 scar, 2 nonspecific, mild superficial perivascular dermatitis specimens, and 1 non-scarring alopecia.
  • In contrast to previous studies, our data indicate that the OCT4 expression is not retained in cutaneous neoplasms derived from basal epidermis or related adnexal neoplasms, including lesions of the scalp.

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  • (PMID = 18091376.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human
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85. Gauerke S, Driscoll JJ: Hidradenocarcinomas: a brief review and future directions. Arch Pathol Lab Med; 2010 May;134(5):781-5
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  • Hidradenocarcinomas are rare, aggressive skin adnexal tumors of sweat gland origin that demonstrate a high potential for local recurrence, metastasis, and poor outcome.
  • These neoplasms can derive from preexisting clear cell hidradenomas but more commonly appear de novo, with the molecular events responsible for the pathogenesis currently unknown.
  • Historically, diagnosis has been difficult because of the few cases, inconsistent nomenclature, variable morphology of cells that compose the neoplasm, and confusion with other visceral metastatic tumors.
  • Presentation is generally benign with an indolent clinical course that typically includes local and multiple recurrences.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Diagnosis, Differential. Humans. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 20441512.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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86. Kapetanakis V, Karlin NJ, McCullough AE, Magtibay PM: Primary ovarian malignant lymphoma presenting as ovarian carcinomatosis: a case report and literature review. Eur J Gynaecol Oncol; 2010;31(6):701-2
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  • CASE: We report a case of a 78-year-old woman who presented with an ovarian neoplasm suggestive of advanced ovarian carcinoma.
  • CONCLUSION: Primary ovarian lymphoma presenting as an ovarian tumor is exceedingly rare.
  • Since the prognosis and treatment of lymphoma differs significantly from ovarian carcinoma, a representative tissue sample of the adnexal tumor should be obtained and sent for frozen section analysis to establish the diagnosis.


87. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Title] Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CASE: A 60-year-old woman, diagnosed with rectal adenocarcinoma 6 months before, underwent fine needle aspiration (FNA) of a nodule on the scalp.
  • CONCLUSION: Rapid, accurate diagnosis of these tumors is important, particularly when they develop at sites where a metastatic process must be ruled out.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Fan YS, Carr RA, Sanders DS, Smith AP, Lazar AJ, Calonje E: Characteristic Ber-EP4 and EMA expression in sebaceoma is immunohistochemically distinct from basal cell carcinoma. Histopathology; 2007 Jul;51(1):80-6
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  • The distinction between these two tumours is important due to the often more locally aggressive nature of BCC and the association of sebaceoma with the Muir-Torre syndrome.
  • A single case exhibited focal weak Ber-EP4 staining, predominantly in mature sebocytes and in < 10% of the tumour cells.
  • We reviewed the immunoreactivity of 51 cases of nodular BCCs and found moderate or strong BerEP4 expression in all cases with never less than 20% of the tumour staining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Mucin-1 / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 17593083.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / human epithelial antigen-125
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89. Dubb M, Michelow P: Cytologic features of chondroid syringoma in fine needle aspiration biopsies: a report of 3 cases. Acta Cytol; 2010 Mar-Apr;54(2):183-6
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  • However, most clinicians prefer to diagnose suspected skin tumors by excisional biopsy as they are easily accessible, with the result that benign skin adnexal tumors are rarely encountered on FNA, often leading to misdiagnosis and mismanagement of patients.
  • Case 2 was an 18-year-old female who presented with a 0.5-cm mass involving the skin of the upper lip.
  • All the masses involved the skin/subcutaneous tissue on clinical examination.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Epithelial Cells / pathology. Female. Humans. Male. Scalp. Skin / pathology. Young Adult

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  • (PMID = 20391975.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. David C, Lupaşcu I, Socolov D, Vişan V: [Large ovarian cyst associated with pregnancy. Case report]. Rev Med Chir Soc Med Nat Iasi; 2008 Oct-Dec;112(4):1007-11
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  • The incidence of adnexal masses in pregnancy is rather low.
  • The management of adnexal masses during pregnancy remains controversial.
  • Ultrasonography can characterise correctly the adnexal mass and avoid antepartum surgery.
  • We present the case of a 32 years old gravida, IV gesta, I para, with an ovarian cystic tumour that enlarged during pregnancy from 7 cm to 20 cm.
  • The tumour was correctly characterised by ultrasound exam (Sassone 3) and surgery was not indicated.

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  • (PMID = 20209778.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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91. Thomassin-Naggara I, Daraï E, Cuenod CA, Fournier L, Toussaint I, Marsault C, Bazot M: Contribution of diffusion-weighted MR imaging for predicting benignity of complex adnexal masses. Eur Radiol; 2009 Jun;19(6):1544-52
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  • [Title] Contribution of diffusion-weighted MR imaging for predicting benignity of complex adnexal masses.
  • The purpose of this study was to prospectively assess the contribution of diffusion-weighted MR imaging (DWI) for characterizing complex adnexal masses.
  • Seventy-seven women (22-87 years old) with complex adnexal masses (30 benign and 47 malignant) underwent MR imaging including DWI before surgery.
  • ADC measurements did not contribute to differentiating benign from malignant adnexal masses.
  • All masses that displayed simultaneously low signal intensity within the solid component on T2-weighted and on b(1,000) diffusion-weighted images were benign.
  • Alternatively, the presence of a solid component with intermediate T2 signal and high b(1,000) signal intensity was associated with a PLR of 4.5 for a malignant adnexal tumour.
  • DWI signal intensity is an accurate tool for predicting benignity of complex adnexal masses.
  • [MeSH-major] Adnexal Diseases / diagnosis. Diffusion Magnetic Resonance Imaging / methods

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  • (PMID = 19214523.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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92. Grey BR, Verma S, Maddineni SB, Lau MW, Clarke NW: Male adnexal tumour of wolffian origin: the first report of metastatic disease. Scand J Urol Nephrol; 2009;43(3):253-6
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  • [Title] Male adnexal tumour of wolffian origin: the first report of metastatic disease.
  • The first case of a male adnexal tumour of probable wolffian duct origin to develop metastatic disease is reported.
  • The characteristic histological appearance and immunohistochemical profiles of the primary and metastatic male tumours are discussed.

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  • (PMID = 18985546.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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93. Van Holsbeke C, Van Calster B, Testa AC, Domali E, Lu C, Van Huffel S, Valentin L, Timmerman D: Prospective internal validation of mathematical models to predict malignancy in adnexal masses: results from the international ovarian tumor analysis study. Clin Cancer Res; 2009 Jan 15;15(2):684-91
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  • [Title] Prospective internal validation of mathematical models to predict malignancy in adnexal masses: results from the international ovarian tumor analysis study.
  • PURPOSE: To prospectively test the mathematical models for calculation of the risk of malignancy in adnexal masses that were developed on the International Ovarian Tumor Analysis (IOTA) phase 1 data set on a new data set and to compare their performance with that of pattern recognition, our standard method.
  • CONCLUSION: This internal validation of mathematical models to estimate the malignancy risk in adnexal tumors shows that the IOTA models had a diagnostic performance similar to that in the original data set.
  • [MeSH-major] Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology

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  • (PMID = 19147775.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Moonda A, Fatteh S: Metastatic colorectal carcinoma: an unusual presentation. J Cutan Pathol; 2009 Jan;36(1):64-6
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  • They most commonly appear on the abdominal wall or perineal area; metastases to other locations of the skin are rare.
  • However, this entity should be considered in the differential diagnosis of adnexal tumors as it may be the initial presentation of the colon carcinoma.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Colorectal Neoplasms / pathology. Lip Neoplasms / secondary. Skin Neoplasms / secondary

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  • (PMID = 18715256.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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95. Plaza JA, Ortega PF, Stockman DL, Suster S: Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol; 2010 Apr;37(4):403-10
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  • [Title] Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
  • The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge.
  • The purpose of this study was to evaluate the role of p63 and podoplanin (D2-40) immunoreactivity for separating primary skin tumors vs. cutaneous metastases of carcinomas from internal organs.
  • Thirty seven primary tumors and 42 cutaneous metastatic adenocarcinomas were evaluated.
  • The 37 primary cutaneous tumors included 14 cases of benign adnexal tumors, 9 malignant skin adnexal neoplasms, and 14 primary squamous and basal cell carcinomas.
  • The 42 metastatic adenocarcinomas all corresponded to metastases from patients with a well-documented history of a primary tumor at another location.
  • We found variable positivity with podoplanin in all primary cutaneous neoplasms including spiradenoma (6/6), hidradenoma (2/4), cylindroma (3/3), desmoplastic trichilemmoma (1/1), poorly differentiated squamous cell carcinoma (4/4), sebaceous carcinoma (1/1), basal cell carcinoma (4/10), trichilemmal carcinoma (2/2), eccrine carcinoma (3/3), microcystic adnexal carcinoma (1/1), adnexal carcinoma NOS (1/1), and porocarcinoma (1/1).
  • In regards to p63, all cases of primary cutaneous tumors were positive for p63 (37/37); in contrast, all cutaneous metastatic carcinomas were negative (0/42).
  • Sensitivity, specificity, and positive and negative predictive values of podoplanin and p63 immunoreactivity to separate primary skin neoplasms from metastatic carcinomas were 78.4, 100.0, 100.0 and 84.0% for podoplanin, respectively, and 100.0, 100.0, 100.0 and 100.0% for p63, respectively.
  • The differences in p63 and podoplanin immunohistochemical expression between primary skin tumors and metastatic carcinomas to the skin were statistically significant (p < 0, 0001).
  • The results of our study suggest that the combined expression of p63 and podoplanin are a useful adjunct for the diagnosis of skin tumors in the clinical setting of a questionable metastasis and may be relatively specific for distinguishing primary skin tumors from metastatic carcinomas to the skin.
  • [MeSH-major] Adenocarcinoma / metabolism. Membrane Glycoproteins / metabolism. Membrane Proteins / metabolism. Skin / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 20377670.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / PDPN protein, human
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96. Sgambato A, Zalaudek I, Ferrara G, Giorgio CM, Moscarella E, Nicolino R, Argenziano G: Adnexal tumors: clinical and dermoscopic mimickers of basal cell carcinoma. Arch Dermatol; 2008 Mar;144(3):426
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  • [Title] Adnexal tumors: clinical and dermoscopic mimickers of basal cell carcinoma.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18347310.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Ivan D, Hafeez Diwan A, Prieto VG: Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin. Mod Pathol; 2005 Jan;18(1):137-42
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  • [Title] Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin.
  • The purpose of this study was to investigate the pattern of p63 expression in cutaneous adnexal neoplasms and to assess its possible value in the differential diagnosis of primary cutaneous neoplasms vs adenocarcinomas metastatic to the skin.
  • Immunohistochemical analysis for p63 was performed on formalin-fixed, paraffin-embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors and 14 adenocarcinomas metastatic to the skin.
  • The expression of p63 was evaluated in epidermal cells, skin appendages and metastatic tumor cells. p63 was consistently expressed in the basal and suprabasal cells of epidermis and cutaneous appendages, including the basal/myoepithelial cells of sweat glands.
  • Out of 20 benign adnexal tumors, 13 (65%) showed strong (score 3) p63 expression; the remaining seven (35%) cases had score 2.
  • In contrast, none of the metastatic adenocarcinomas to the skin was positive for p63 (P<0.001).
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasms, Adnexal and Skin Appendage / pathology. Phosphoproteins / biosynthesis. Skin / pathology. Skin Neoplasms / pathology. Trans-Activators / biosynthesis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Epidermis / chemistry. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins


98. Deen S, Duncan TJ, Hammond RH: Malignant female adnexal tumors of probable Wolffian origin. Int J Gynecol Pathol; 2007 Oct;26(4):383-6
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  • [Title] Malignant female adnexal tumors of probable Wolffian origin.
  • Female adnexal tumors of probable Wolffian origin are rare.
  • Although the histological features of the benign tumors are recognized, features of malignancy are not well defined in published work because these tumors are particularly rare.
  • Immunohistochemical staining and electron microscopy supported the diagnosis of female adnexal tumor of probable Wolffian origin.
  • There was significant and widespread nuclear pleomorphism with increased mitotic activity endorsing the diagnosis of a malignant tumor.
  • Seven months after initial surgery, follow-up magnetic resonance imaging showed a mass with a maximum diameter of 7 cm in the region of the right adnexa consistent with a recurrence.
  • [MeSH-major] Adnexal Diseases / pathology. Wolffian Ducts / pathology

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  • (PMID = 17885487.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. González-Guerra E, Requena L, Kutzner H: [Immunohistochemical study of calretinin in normal hair follicles and tumors with follicular differentiation]. Actas Dermosifiliogr; 2008 Jul-Aug;99(6):456-63
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  • [Title] [Immunohistochemical study of calretinin in normal hair follicles and tumors with follicular differentiation].
  • [Transliterated title] Estudio inmunohistoquímico de la calretinina en el folículo piloso normal y neoplasias con diferenciación folicular.
  • OBJECTIVE: The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.
  • MATERIAL AND METHODS: We analyzed the staining pattern for calretinin by immunohistochemistry in 49 biopsies of cutaneous adnexal tumors with follicular differentiation.
  • Two pilomatricomas and 3 proliferative trichilemmal tumors had positive staining in the cellular layers close to the lumen of the cystic structures.
  • CONCLUSION: Immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors of the hair follicle or a component of the follicle with differentiation towards cells of the outer root sheath.
  • [MeSH-major] Hair Follicle / chemistry. Neoplasm Proteins / analysis. S100 Calcium Binding Protein G / analysis. Skin Neoplasms / chemistry
  • [MeSH-minor] Acanthoma / chemistry. Acanthoma / pathology. Calbindin 2. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / chemistry. Carcinoma, Skin Appendage / pathology. Cell Differentiation. Epidermal Cyst / metabolism. Epidermal Cyst / pathology. Hamartoma / metabolism. Hamartoma / pathology. Humans. Neoplasms, Basal Cell / chemistry. Neoplasms, Basal Cell / pathology. Skin Diseases / metabolism. Skin Diseases / pathology

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  • (PMID = 18558053.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G
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100. Adamicová K, Fetisovová Z, Mellová Y, Výbohová D: [Diagnostic procedures in skin adnexal tumours]. Cesk Patol; 2006 Apr;42(2):59-65
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  • [Title] [Diagnostic procedures in skin adnexal tumours].
  • From histogenetic, morphologic and immunohistochemical point of view the authors try to make possible algorithms that can be employed in a routine diagnosis of adnexal skin tumours.
  • They stress the importance of knowledge of clinical data necessary for orientation classification of tumour skin lesions after biopsies.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis

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  • (PMID = 16715628.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 33
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