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1. Kinkor Z, Skálová A, Michal M, Janousek M, Kheck M: [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. Ceska Gynekol; 2005 May;70(3):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Due to the aggressive course in two cases, the review of the literature does not concentrate on morphology and differential diagnosis only, but discuss overall biology of this lesion too.
  • RESULTS: Partial mastectomy and segmentectomy were performed in three women 46, 72 and 74 years-old resp. for tumor, which size ranged from 20-35 mm in maximum diameter (mean 28 mm).
  • The stromal component expressed smooth muscle actin in two cases, one of which contained areas of heterologous chondrosseal differentiation.
  • In two women with aggressive course the original biopsy was falsely interpreted, once as phyllodes tumor and secondly as benign sclerosing pseudotumor.
  • It arises in the deep breast tissue and structurally resembles the microcystic adnexal carcinoma of the skin.
  • Low-grade adenosquamous carcinoma, however, has nothing to do with syringomatous adenoma of the nipple, which is a benign tumor of the skin adnexa.
  • Differential diagnosis includes spectrum of non-neoplastic slerosing lesions and above-mentioned phylloid tumor.
  • The rarity of this neoplasm does not exclude deep knowledge.


2. Oliva VL, Little JV, Carlson GW: Syringomatous adenoma of the nipple--treatment by central mound resection and oncoplastic reconstruction. Breast J; 2008 Jan-Feb;14(1):102-5
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  • Syringomatous adenoma (SA) of the nipple is a rare tumor first described by Rosen in 1983.
  • It is histologically similar to skin adnexal tumors in other parts of the body.
  • [MeSH-minor] Abscess / pathology. Adult. Diagnosis, Differential. Female. Humans. Mammaplasty

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  • (PMID = 18186873.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Savar A, Ross MI, Prieto VG, Ivan D, Kim S, Esmaeli B: Sentinel lymph node biopsy for ocular adnexal melanoma: experience in 30 patients. Ophthalmology; 2009 Nov;116(11):2217-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sentinel lymph node biopsy for ocular adnexal melanoma: experience in 30 patients.
  • PURPOSE: To report the findings on sentinel lymph node biopsy (SLNB) in 30 patients with ocular adnexal (conjunctival or eyelid) melanomas.
  • PARTICIPANTS: Thirty patients with diagnosis of eyelid or conjunctival melanoma.
  • METHODS: All patients with ocular adnexal melanoma who underwent SLNB at The University of Texas MD Anderson Cancer Center between December 2000 and July 2008 are the subject of this report.
  • MAIN OUTCOME MEASURES: Findings on preoperative lymphoscintigraphy, SLNB, histopathologic examination of the primary tumor and sentinel lymph nodes (SNL), and nodal recurrence after SLNB.
  • RESULTS: Tumor sites were as follows: bulbar conjunctiva only, 14 patients; palpebral conjunctiva only, 8 patients; both bulbar and palpebral conjunctiva, 4 patients; and eyelid skin only, 4 patients.
  • CONCLUSIONS: Sentinel lymph node biopsy is effective for identifying nodal micrometastasis in patients with ocular adnexal melanoma and provides important prognostic information.
  • We recommend consideration of SLNB for patients with intermediate-thickness ocular adnexal melanoma and those with ulceration.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / analysis. False Positive Reactions. Female. Humans. Lymph Nodes / radionuclide imaging. Lymphatic Metastasis. MART-1 Antigen. Male. Melanoma-Specific Antigens. Middle Aged. Monophenol Monooxygenase / analysis. Neoplasm Proteins / analysis. Predictive Value of Tests. Prognosis. Prospective Studies. Sentinel Lymph Node Biopsy. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 19766318.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; EC 1.14.18.1 / Monophenol Monooxygenase
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4. Kazakov DV, Kutzner H, Mukensnabl P, Michal M: Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation. Am J Dermatopathol; 2006 Aug;28(4):341-5
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  • [Title] Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation.
  • The conjoint occurrence of follicular, sebaceous, or apocrine differentiations in a cutaneous adnexal neoplasm is a known event, more often encountered in benign neoplasms, whereas reports of cutaneous malignant adnexal tumors with bilineage or trilineage differentiation are few.
  • A new case of a cutaneous malignant adnexal neoplasm with multidirectional differentiation is reported here.
  • A 57-year-old woman presented with a long-standing, slowly growing, asymptomatic solitary tumor the size of a large nut in the coccygeal area, which was surgically excised.
  • Microscopically, the neoplasm was located in the dermis with focal extension into the subcutis.
  • We classified this tumor as a well-differentiated adnexal carcinoma demonstrating combined follicular and apocrine differentiation.
  • It differs from previously published cases of malignant adnexal tumors with multidirectional differentiation and further exemplifies the spectrum of diversity encountered in malignant proliferations with differentiation toward the folliculosebaceous-apocrine unit.
  • [MeSH-major] Adnexal Diseases / pathology. Cell Differentiation. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Shape. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging

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  • (PMID = 16871040.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Nagatsuka H, Rivera RS, Gunduz M, Siar CH, Tamamura R, Mizukawa N, Asaumi J, Nagai N: Microcystic adnexal carcinoma with mandibular bone marrow involvement: a case report with immunohistochemistry. Am J Dermatopathol; 2006 Dec;28(6):518-22
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  • [Title] Microcystic adnexal carcinoma with mandibular bone marrow involvement: a case report with immunohistochemistry.
  • Microcystic adnexal carcinoma is a rare, locally aggressive cutaneous neoplasm with a high probability of persistence locally but a low probability of metastasis.
  • Histologically, the tumor cells invaded the subcutaneous tissue and mandibular bone.
  • The tumor consisted mainly of squamous and basaloid epithelial nests and cords embedded in a desmoplastic stroma.
  • Our results indicate that microcystic adnexal carcinoma consists of tumor cells capable of both follicular and eccrine differentiation.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Lip Neoplasms / pathology. Mandibular Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoembryonic Antigen / metabolism. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. S100 Proteins / metabolism

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  • (PMID = 17122497.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / S100 Proteins
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6. Bircan S, Candir O, Kapucoglu N, Baspinar S: The expression of p63 in basal cell carcinomas and association with histological differentiation. J Cutan Pathol; 2006 Apr;33(4):293-8
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  • [Title] The expression of p63 in basal cell carcinomas and association with histological differentiation.
  • BACKGROUND: We aim to examine p63 expression in basal cell carcinomas (BCCs) and to investigate association with their histopathological differentiation subtypes.
  • METHODS: Eighty-four BCCs were classified according to the histopathologic differentiation subtypes.
  • RESULTS: In nontumoral skin, p63 expression was consistently seen in basal/suprabasal cells of epidermis, hair matrix cells, and outer root sheath of the hair follicle.
  • There was no statistically significant difference between p63 expression and histological differentiation subtypes (p > 0.05).
  • CONCLUSIONS: p63 is consistently expressed in epidermal basal/suprabasal and adnexal basal cells.
  • Most BCCs have higher homogeneous p63 expression than nontumoral epidermis, which is not changed according to histological differentiation subtypes.
  • Thus, overexpression of p63 in all histological subtypes may confirm that basaloid progenitor cells are linked tumor-cell lineage and have a role in the tumorigenesis of BCC.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Cell Differentiation. Membrane Proteins / metabolism. Skin / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Gene Expression. Humans. Immunohistochemistry. Neoplasm Staging. Retrospective Studies

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  • (PMID = 16630179.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins
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7. Su W, Kheir SM, Berberian B, Cockerell CJ: Merkel cell carcinoma in situ arising in a trichilemmal cyst: a case report and literature review. Am J Dermatopathol; 2008 Oct;30(5):458-61
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  • The stain for cytokeratin 20 "decorated" the tumor cells with an unequivocal perinuclear dot-like pattern, confirming their Merkel cell origin.
  • Dermal Merkel cell carcinoma (MCC) arising in association with benign adnexal tumors or cysts, with or without epithelial involvement, is a rare event.
  • [MeSH-major] Carcinoma in Situ / diagnosis. Carcinoma in Situ / pathology. Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 18806489.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20
  • [Number-of-references] 46
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8. Pulitzer M, Desman G, Busam KJ: CK7 expression in primary cutaneous squamous cell carcinoma. J Cutan Pathol; 2010 Sep;37(9):966-72
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  • [Title] CK7 expression in primary cutaneous squamous cell carcinoma.
  • AIM: To evaluate cytokeratin 7 (CK7) immunoreactivity in invasive primary cutaneous squamous cell carcinomas (SCCs).
  • METHODS: Twenty-seven primary cutaneous SCCs from 25 patients were evaluated for tumor grade using hematoxylin and eosin-stained slides and for percentage and intensity of immunoreactivity for CK7.
  • No glandular or tubular differentiation was present.
  • Of immunoreactive cases, percentage of tumor staining and distribution of immunoreactivity was documented.
  • The remaining immunoreactive tumor was moderately differentiated, with 1+ intensity and 5% staining in an area of microinvasion.
  • CONCLUSION: A subset of cutaneous SCCs, in particular, poorly differentiated tumors, may show focal-to-partial immunoreactivity for CK7.
  • This is important to bear in mind when immunohistochemistry is used to distinguish SCC from simulants, such as porocarcinoma, or other adnexal carcinomas with squamous metaplasia.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Keratin-7 / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Count. Diagnosis, Differential. Eccrine Porocarcinoma / diagnosis. Humans. Immunohistochemistry. Neoplasms, Adnexal and Skin Appendage / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 20528966.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-7
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9. Kavand S, Cassarino DS: "Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma? Am J Dermatopathol; 2009 Dec;31(8):849-52
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  • [Title] "Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma?
  • Squamoid eccrine ductal carcinoma is a rare primary cutaneous tumor exhibiting both squamous and adnexal ductal differentiation.
  • The cell of origin of these tumors is unknown, and they have been classified both as variants of cutaneous squamous cell carcinoma and as a type of eccrine carcinoma.
  • We report an additional case of a slow-growing tumor, occurring on the great toe of a 61-year-old woman, which was unusual as it showed follicular differentiation in addition to squamoid and ductal areas.
  • The lesional cells were positive for cytokeratins 7 and 17, carcinoembryonic antigen (which highlighted the ductal structures), and p63 (favoring a primary cutaneous tumor) and showed low levels of staining with Ki-67 and p53, consistent with a low-grade tumor.
  • We postulate that these tumors may be closely related to microcystic adnexal carcinoma and similarly show differentiation along both follicular and ductal lines, likely indicating folliculosebaceous-apocrine, rather than eccrine, origin or differentiation.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Hair Follicle / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Differentiation. Female. Humans. Immunohistochemistry. Middle Aged. Toes / pathology

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  • (PMID = 19786851.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Ntomouchtsis A, Vahtsevanos K, Patrikidou A, Andreadis C, Tsobanidou C, Antoniades K: Adnexal skin carcinomas of the face. J Craniofac Surg; 2009 Jan;20(1):134-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal skin carcinomas of the face.
  • Skin adnexal neoplasms are rare tumors, and knowledge on their exact histological development and pathogenesis remains fragmented.
  • Their diagnosis and management are frequently troublesome, especially for malignant tumors.
  • Records of patients with histologically confirmed adnexal skin carcinoma managed at a single department during the period 1995 to 2004 were reviewed.
  • Clinical and histological features, tumor biological behavior, diagnostic difficulties, and recommended management are discussed.In conclusion, adnexal skin tumors should be considered in the differential diagnosis of skin tumors, particularly in view of their more sinister prognosis compared with other nonmelanoma skin tumors.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Facial Neoplasms / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Cohort Studies. Diagnosis, Differential. Disease-Free Survival. Eyelid Neoplasms / surgery. Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local / pathology. Neoplasms, Second Primary / pathology. Nose Neoplasms / surgery. Retrospective Studies. Surgical Flaps. Survival Rate. Treatment Outcome

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  • (PMID = 19165010.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Kazakov DV, Vanecek T, Belousova IE, Mukensnabl P, Kollertova D, Michal M: Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast. Am J Dermatopathol; 2007 Oct;29(5):457-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast.
  • Skin adnexal type tumors situated in the parenchyma of the breast are very rare.
  • The tumor was situated in the parenchyma of the breast of a 55-year-old female and showed no connection to the overlying skin on ultrasound and radiology investigations, grossly and microscopically.
  • Histologically, the tumor was identical to its cutaneous counterpart and was surrounded by breast tissue.
  • The neoplasm was composed of solid and cystic areas.
  • Several mammary ducts in close proximity to the tumor showed features of columnar cell hyperplasia.
  • This t(11;19) translocation has been reported in approximately 50% of hidradenomas of the skin.

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  • (PMID = 17890914.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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12. Karthikeyan P, Paulraj P: An unusual benign tumor of pinna - A case report. Indian J Otolaryngol Head Neck Surg; 2010 Jun;62(2):195-7
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  • [Title] An unusual benign tumor of pinna - A case report.
  • This case is being reported as it is a rare skin adnexal tumor arising from an unusual site.

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  • (PMID = 23120714.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450310
  • [Keywords] NOTNLM ; Hamartoma / Skin adnexal tumor / Tricho folliculoma
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13. Moosavi C, Jha P, Fanburg-Smith JC: An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD. Ann Diagn Pathol; 2007 Oct;11(5):313-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD.
  • The seminal article of Drs Franz Enzinger and Renyuan Zhang in 1988 defined plexiform fibrohistiocytic tumor (PFHT) as a distinctive entity.
  • Perineural growth was observed in 5 cases, peri-Pacinian corpuscle growth in 2 cases, adnexal trapping in several, and, increased hyalinized collagen in 17 cases.
  • Overall, the findings were very similar to the original observations made by Dr Enzinger and his colleague, with the minor exceptions of roughly equal sex distribution (possibly due to timely referral bias), and additional morphologic features of myxoid change, adnexal sparing, increased inflammation, and microfat similar to recently described lipofibromatosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Adolescent. Adult. Aged. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Child. Child, Preschool. Female. Humans. Immunophenotyping. Infant. Male. Middle Aged. Neurothekeoma / diagnosis. Neurothekeoma / metabolism. Neurothekeoma / pathology

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  • (PMID = 17870015.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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14. Kantrow SM, Ivan D, Williams MD, Prieto VG, Lazar AJ: Metastasizing adenocarcinoma and multiple neoplastic proliferations arising in a nevus sebaceus. Am J Dermatopathol; 2007 Oct;29(5):462-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nevus sebaceus of Jadassohn is a hamartoma of multiple skin structures.
  • On histologic evaluation, the epidermis showed changes reminiscent of tumor of the follicular infundibulum as well as basaloid proliferations resembling superficial trichoblastoma.
  • Most of the lesion was composed of an adenocarcinoma with areas showing ductal differentiation with decapitation secretion, well-formed papillae and focal cribriform structures.
  • Other portions demonstrated a high-grade neoplasm with prominent nuclear atypia and a solid pattern of growth resembling high-grade breast carcinoma.
  • Anti-epithelial membrane antigen strongly labeled tumor cells and highlighted ductal structures.
  • Anti-p63 labeled basaloid cells surrounding the tumor lobules.
  • This report illustrates an extraordinary case of adnexal neoplasia displaying various lines of differentiation arising in association with nevus sebaceus.
  • [MeSH-major] Adenocarcinoma / secondary. Head and Neck Neoplasms / secondary. Nevus / pathology. Skin Neoplasms / pathology


15. Mulder MM, Heddema ER, Pannekoek Y, Faridpooya K, Oud ME, Schilder-Tol E, Saeed P, Pals ST: No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands. Leuk Res; 2006 Oct;30(10):1305-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands.
  • Recently, conflicting data have been published regarding a possible association between Chlamydia psittaci and ocular adnexal MZBCL.
  • In the present study, we analyzed a cohort of ocular adnexal MZBLs from the Netherlands for the presence of C. psittaci DNA.
  • We found no evidence for the presence of C. psittaci DNA in any of the tumor samples studied.
  • Our data do not support a role for C. psittaci in the pathogenesis of ocular adnexal lymphomas in patients from the Netherlands.
  • [MeSH-major] Chlamydia Infections / complications. Chlamydophila psittaci. Eye Neoplasms / epidemiology. Lymphoma, B-Cell / epidemiology. Neoplasms, Adnexal and Skin Appendage / epidemiology

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  • (PMID = 16420962.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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16. Khachemoune A, Olbricht SM, Johnson DS: Microcystic adnexal carcinoma: report of four cases treated with Mohs' micrographic surgical technique. Int J Dermatol; 2005 Jun;44(6):507-12
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  • [Title] Microcystic adnexal carcinoma: report of four cases treated with Mohs' micrographic surgical technique.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare and aggressive malignant tumor of the sweat glands.
  • On histology, MAC exhibits both pilar and sweat duct differentiation with a stroma of dense collagen.
  • The accumulated data continue to confirm that, if the diagnosis of MAC is made early, and if the anatomic location is accessible to excision by MMS, a favorable outcome can be expected.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Facial Neoplasms / surgery. Mohs Surgery. Scalp / surgery. Skin Neoplasms / surgery

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  • (PMID = 15941444.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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17. Kazakov DV, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, Grossmann P, Michal M: Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol; 2009 May;31(3):248-55
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  • [Title] Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
  • Previous studies suggested that mutant beta-catenin gene cells in cutaneous adnexal tumors with matrical differentiation contribute to their tumorigenesis.
  • Except for pilomatricoma and pilomatrical carcinoma, only a handful of other cutaneous adnexal tumor types have been studied.
  • DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene.
  • These included 5 different point mutations, 3 of them identified in 2 different tumors: S23N (cribriform trichoblastoma), D32Y (pilomatricoma and craniopharyngioma), G34R (pilomatrical carcinoma and craniopharyngioma), S37F (2 BCCs with shadow cell differentiation), and G34V (craniopharyngioma).
  • This study broadens the list of cutaneous adnexal tumors harboring CTNNB1 mutations and extends the listing of the mutations occurring in these neoplasms.
  • [MeSH-major] Exons. Mutation. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Base Sequence. Cell Differentiation. Child. Child, Preschool. Craniopharyngioma / genetics. DNA Mutational Analysis. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Molecular Sequence Data. Pituitary Neoplasms / genetics. Young Adult

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  • (PMID = 19384065.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
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18. Riedlinger WF, Hurley MY, Dehner LP, Lind AC: Mucoepidermoid carcinoma of the skin: a distinct entity from adenosquamous carcinoma: a case study with a review of the literature. Am J Surg Pathol; 2005 Jan;29(1):131-5
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  • [Title] Mucoepidermoid carcinoma of the skin: a distinct entity from adenosquamous carcinoma: a case study with a review of the literature.
  • Mucoepidermoid carcinoma (MEC) of the skin is an exceedingly rare but distinctive neoplasm with respect to its histopathologic features.
  • It is similar if not identical in most respects to MEC of the salivary gland, a neoplasm whose prognosis is correlated with the pathologic grade.
  • We report a case of MEC of the skin in a 79-year-old white woman who presented with an axillary mass.
  • Beneath an unremarkable epidermis, a circumscribed, cystic neoplasm, unattached to the surface, was characterized by the presence of vague lobules of low-grade-appearing squamous cells accompanied by mucigenic and clear cells.
  • Inconsistency was encountered in the literature where some confusion existed as to whether MEC is synonymous with adenosquamous carcinoma of the skin.
  • Elsewhere in the body, the latter tumor type is a squamous and gland-forming neoplasm with intermediate- to high-grade features rather than a tumor with mucigenic cells intermingled among intermediate and squamous cells.
  • As in the case of MEC and adenosquamous carcinoma elsewhere in extracutaneous sites, we would propose that a pathologic distinction should be made in the skin for the sake of consistency and for prognostic purposes.
  • Additionally, the immunophenotype of our case is similar to at least two other cases of cutaneous MEC, as well as MEC of the salivary gland, to support the hypothesis that this neoplasm is adnexal rather than epidermal in origin.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Carcinoma, Mucoepidermoid / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans

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  • (PMID = 15613868.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 45
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19. Chanudet E, Ye H, Ferry J, Bacon CM, Adam P, Müller-Hermelink HK, Radford J, Pileri SA, Ichimura K, Collins VP, Hamoudi RA, Nicholson AG, Wotherspoon AC, Isaacson PG, Du MQ: A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands. J Pathol; 2009 Feb;217(3):420-30
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  • [Title] A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands.
  • We compared the genetic profiles of 33 ocular adnexal and 25 pulmonary MALT lymphomas by 1 Mb array-comparative genomic hybridization (CGH) and revealed recurrent 6q23 losses and 6p21.2-6p22.1 gains exclusive to ocular cases.
  • Interphase fluorescence in situ hybridization showed that A20 deletion occurred in MALT lymphoma of the ocular adnexa (8/42=19%), salivary gland (2/24=8%), thyroid (1/9=11%) and liver (1/2), but not in the lung (26), stomach (45) and skin (13).
  • In ocular cases, A20 deletion was associated with concurrent involvement of different adnexal tissues or extraocular sites at diagnosis (p=0.007), a higher proportion of relapse (67% versus 37%) and a shorter relapse-free survival (p=0.033).
  • [MeSH-major] Intracellular Signaling Peptides and Proteins / genetics. Lymphoma, B-Cell, Marginal Zone / genetics. Nuclear Proteins / genetics. Orbital Neoplasms / genetics. Salivary Gland Neoplasms / genetics. Tumor Necrosis Factor-alpha / genetics
  • [MeSH-minor] Aged. Aged, 80 and over. Chromosome Aberrations. Chromosomes, Human, Pair 6. Comparative Genomic Hybridization / methods. DNA-Binding Proteins. Female. Gene Expression Profiling / methods. Humans. In Situ Hybridization, Fluorescence. Interphase. Liver Neoplasms / genetics. Lung Neoplasms / genetics. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Sequence Deletion. Skin Neoplasms / genetics. Stomach Neoplasms / genetics. Thyroid Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 19006194.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Nuclear Proteins; 0 / Tumor Necrosis Factor-alpha; EC 6.3.2.19 / TNFAIP3 protein, human
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20. Kim YH, Lee YK, Choi KW, Lee CY, Kim KH: A Case of Trichilemmal Carcinoma Treated with Mohs Micrographic Surgery. Ann Dermatol; 2008 Sep;20(3):157-61
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  • Trichilemmal carcinoma is a cutaneous adnexal tumor originating from the outer root sheath of hair follicle, and it was first described by Headington in 1976.
  • This neoplasm is a malignant counterpart of trichilemmoma, and it has been reported in the literature as trichilemmal carcinoma, tricholemmal carcinoma, malignant trichilemmoma, and tricholemmocarcinoma.
  • We think Mohs micrographic surgery is a useful treatment modality in trichilemmal carcinoma because the final skin defect is smaller than a wide excision.

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  • (PMID = 27303183.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4903970
  • [Keywords] NOTNLM ; Mohs micrographic surgery / Trichilemmal carcinoma
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21. Dalton SR, LeBoit PE: Squamous cell carcinoma with clear cells: how often is there evidence of tricholemmal differentiation? Am J Dermatopathol; 2008 Aug;30(4):333-9
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  • [Title] Squamous cell carcinoma with clear cells: how often is there evidence of tricholemmal differentiation?
  • Clear-cell carcinoma of the skin was described by Kuo in 1980 as a cutaneous tumor composed of clear cells that lacked cytoplasmic glycogen or evidence of tricholemmal keratinization.
  • Tricholemmal carcinoma (TC) is conventionally considered to be a neoplasm derived from adnexal keratinocytes with glycogenated clear cells and evidence of outer root sheath or tricholemmal differentiation.
  • The existence of TC has been questioned as it has been argued that without clear immunohistochemical evidence of outer root sheath differentiation, TC cannot be distinguished from clear-cell carcinoma of the skin.
  • Our laboratory has not routinely stained the cases that appear to be carcinomas with clear keratinocytes to determine if glycogen is present and has not made the diagnosis of TC.
  • Selected cases were then stained for immunohistochemical markers (CD34, CK17, and NGFR/p75) that have been used as evidence for tricholemmal differentiation in some studies.
  • Rare cases of SCC-C met the majority of Headington's criteria for TC or showed immunohistochemical evidence of tricholemmal differentiation.
  • Thus, we also conclude that well-differentiated TC is rare and its description in the literature may overstate the case that it is a well-characterized cutaneous neoplasm.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology


22. Kamiya H, Kitajima Y, Ban M: Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells. J Dermatol; 2006 Dec;33(12):858-64
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  • [Title] Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
  • Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions.
  • Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition.
  • Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma.
  • In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma.
  • The tumor in case 2 was characteristic to trichilemmal carcinoma.
  • Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma, Skin Appendage / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Acrospiroma / pathology. Aged. Aged, 80 and over. Female. Humans. Neoplasm Invasiveness. Neoplasms, Basal Cell / pathology

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  • (PMID = 17169090.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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23. Patton A, Page R, Googe PB, King R: Myxoid atypical fibroxanthoma: a previously undescribed variant. J Cutan Pathol; 2009 Nov;36(11):1177-84
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  • BACKGROUND: Atypical fibroxanthomas (AFX) are dermal-based cutaneous tumors typically found in sun-damaged skin of the elderly.
  • A junctional component was absent and the tumors did not arise from the epidermis or adnexal structures.
  • Tumor cells were negative for melanocytic and epithelial markers.
  • Myxoid change may be a prominent finding in benign and malignant cutaneous tumors and awareness of this variant of AFX will avoid misdiagnosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 19320792.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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24. Krishnamurthy J, Divya K: The cytology of giant solitary trichoepithelioma. J Cytol; 2010 Jul;27(3):99-101
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  • Giant solitary trichoepithelioma (GST) is a rare trichogenic tumor, which may present as a pigmented lesion.
  • The recognition of GST is important because of its close resemblance to basal cell carcinoma and other skin adnexal tumors - clinically, cytologically and histologically.

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  • (PMID = 21187885.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2983083
  • [Keywords] NOTNLM ; FNAC / Giant solitary trichoepithelioma / basal cell carcinoma / microcystic adnexal carcinoma / trichoblastoma
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25. Manonukul J, Omeapinyan P, Vongjirad A: Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. Am J Dermatopathol; 2009 Oct;31(7):658-63
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  • [Title] Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case.
  • Nevus sebaceous of Jadassohn (SNJ) is a congenital, hamartoma of multiple skin structures and may classically evolve through several stages of maturation.
  • We report a case of a 66-year-old woman with a coexistence of trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum, syringocystadenoma papilliferum, and mucoepidermoid or adenosquamous carcinoma arising in 2 separate and persistent SNJ exhibiting on her face with subsequent parotid node metastasis.
  • This report illustrates an extraordinary case of adnexal neoplasms displaying diverse lines of differentiation arising within lesions of SNJ.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology


26. Ohtsuka H, Nozawa R, Kushida Y: Synchronous microcystic adnexal carcinoma and gastric cancer with review of the literature. J Dermatol; 2005 Jan;32(1):43-7
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  • [Title] Synchronous microcystic adnexal carcinoma and gastric cancer with review of the literature.
  • A microcystic adnexal carcinoma (MAC) on the left lateral chest was synchronously accompanied by both an adenocarcinoma and a granular cell tumor of the stomach in a 70-year-old Japanese male.
  • After a definitive diagnosis was made by an excisional biopsy, a second operation was performed with wider excision, followed by split thickness skin grafting.
  • Three lymph nodes were excised for diagnostic purposes and found to be reactive hyperplasia without metastasis of skin tumor cells.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Granular Cell Tumor / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Thorax


27. Vidyavathi K, Udayakumar M, Prasad CB, Harendra KM: Glomus tumor mimicking eccrine spiradenoma on fine needle aspiration. J Cytol; 2009 Jan;26(1):46-8
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  • [Title] Glomus tumor mimicking eccrine spiradenoma on fine needle aspiration.
  • The histologic features of glomus tumor are characteristic and do not pose any diagnostic difficulty.
  • We present a case of glomus tumor which mimicked a cutaneous adnexal neoplasm - eccrine spiradenoma on fine needle aspiration.

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  • (PMID = 21938152.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3167993
  • [Keywords] NOTNLM ; Aspiration cytology / eccrine spiradenoma / glomus tumor
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28. Thomas CJ, Wood GC, Marks VJ: Mohs micrographic surgery in the treatment of rare aggressive cutaneous tumors: the Geisinger experience. Dermatol Surg; 2007 Mar;33(3):333-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs micrographic surgery in the treatment of rare aggressive cutaneous tumors: the Geisinger experience.
  • BACKGROUND: Mohs micrographic surgery (MMS) offers high cure rates and maximum tissue preservation in the treatment of more common cutaneous malignancies, but its effectiveness in rare aggressive tumors is poorly defined.
  • OBJECTIVE: Evaluate the effectiveness of MMS in the treatment of six rare aggressive cutaneous malignancies as seen by Mohs surgeons working at a referral center.
  • METHODS: Retrospective chart review of 26,000 cases treated with MMS at the Geisinger Medical Center Department of Dermatology during a 16-year period with the following diagnoses: poorly differentiated squamous cell carcinoma (PDSCC), dermatofibrosarcoma protuberans (DFSP), microcystic adnexal carcinoma (MAC), extramammary Paget's disease (EMPD), Merkel cell carcinoma (MCC), and sebaceous carcinoma (SEB CA).
  • Patient demographic data, tumor measurements, treatment characteristics, and marginal recurrence rates were compiled and evaluated.
  • RESULTS: The mean numbers of cases identified per year for each tumor type were as follows: PDSCC, 6.19; DFSP, 2.44; MAC, 1.63; and EMPD, 0.63.
  • CONCLUSIONS: Collectively, our data on PDSCC, DFSP, MAC, and EMPD, combined with other studies in the literature, show that MMS is the most effective therapy for these rare aggressive cutaneous malignancies.
  • [MeSH-major] Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Merkel Cell / surgery. Carcinoma, Squamous Cell / surgery. Child. Child, Preschool. Dermatofibrosarcoma / surgery. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Paget's Disease, Mammary / surgery. Retrospective Studies. Treatment Outcome

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  • (PMID = 17338692.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Coupland SE, Jaehne D, Hummel M, Stein H: The tale and molecular trail of a disseminated ocular adnexal malt lymphoma. Graefes Arch Clin Exp Ophthalmol; 2007 Jul;245(7):1055-9
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  • [Title] The tale and molecular trail of a disseminated ocular adnexal malt lymphoma.
  • Excisional biopsy of the tumour revealed a low-grade malignant B-cell Non-Hodgkin lymphoma (NHL) of MALT type.
  • Despite localized radiochemotherapy, the patient developed recurrences occurring in the pharynx, in the right orbit, in the skin of the right foot, and in the bone marrow 1, 7, 11 and 14 years, respectively, after establishment of the first diagnosis.
  • CONCLUSIONS: It is generally assumed that ocular adnexal MALT lymphoma is associated with an indolent clinical course.
  • [MeSH-major] Bone Marrow Neoplasms / pathology. Eyelid Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Nasopharyngeal Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics. Humans. Immunoenzyme Techniques. Immunoglobulin Heavy Chains / genetics. Middle Aged. Neoplasm Recurrence, Local. Polymerase Chain Reaction

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  • [Cites] Hematol Oncol. 2004 Dec;22(4):143-58 [16134191.001]
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  • (PMID = 17219122.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Immunoglobulin Heavy Chains
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30. Yu Y, Finn DT, Rogers GS: Microcystic adnexal carcinoma: a rare, locally aggressive cutaneous tumor. Am J Clin Oncol; 2010 Apr;33(2):196-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcystic adnexal carcinoma: a rare, locally aggressive cutaneous tumor.
  • [MeSH-major] Carcinoma, Ductal / pathology. Carcinoma, Skin Appendage / pathology. Lymph Nodes / pathology. Skin Neoplasms / pathology

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  • [CommentOn] Am J Clin Oncol. 2010 Apr;33(2):125-7 [19675445.001]
  • (PMID = 20375780.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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31. Dubb M, Michelow P: Fine needle aspiration cytology of pilomatrixoma and differential diagnoses. Acta Cytol; 2009 Nov-Dec;53(6):683-8
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  • OBJECTIVE: To review the cytologic features of pilomatrixoma to allow a definitive diagnosis at the time of aspiration and correct patient management.
  • STUDY DESIGN: Three patients each presented with a mass lesion and on fine needle aspiration were diagnosed as either having pilomatrixoma or a benign skin adnexal tumor.
  • The diagnosis was confirmed on histology.
  • RESULT: The most consistent and predominant features for diagnosis were basaloid cells, anucleate squamous cells and calcification in an inflammatory background, often with giant cells.
  • Therefore, lack of shadow cells does not preclude correct diagnosis in the presence of the other relevant cytologic features.
  • If all the major components of pilomatrixoma are present in an aspirate, the diagnosis should not be problematic.
  • However, if one component predominates, this may lead to an erroneous diagnosis of other benign and malignant lesions.
  • CONCLUSION: Knowledge of the cytologic features of pilomatrixoma will allow correct patient diagnosis and management.
  • [MeSH-major] Hair Diseases / pathology. Pilomatrixoma / diagnosis. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Humans. Middle Aged. Young Adult

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  • (PMID = 20014559.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Abdulla AN, Covert AA, Grantmyre JE: Scrotal syringocystadenoma papilliferum: case report. Can J Urol; 2009 Jun;16(3):4684-6
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  • Syringocystadenoma papilliferum (SCAP) is a benign rare adnexal skin neoplasm, which in a third of cases arises from a nevus sebaceous and is most commonly found on the head and neck and in very rare instances found on the genitalia.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Scrotum / pathology. Skin Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19497181.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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33. Koletsa T, Hytiroglou P, Semoglou C, Drevelegas A, Karkavelas G: Angiomatoid fibrous histiocytoma with cystic structures of sweat duct origin. Pathol Int; 2007 Aug;57(8):513-6
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  • Angiomatoid fibrous histiocytoma is an unusual soft tissue tumor, mostly arising in the subcutaneous fibro-adipose tissue of children and young adults and measuring a few centimeters in greatest dimension.
  • This large tumor (12 cm) was located in the subcutaneous tissue of the left leg of a 28-year-old woman.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Soft Tissue Neoplasms / pathology. Sweat Glands / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cysts / chemistry. Cysts / pathology. Cysts / surgery. Female. Humans. Immunohistochemistry. Leg / pathology. Magnetic Resonance Imaging. Treatment Outcome

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  • (PMID = 17610476.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R: Squamoid eccrine ductal carcinoma: a case report and review of the literature. Am J Dermatopathol; 2010 May;32(3):287-92
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  • Eccrine ductal carcinoma is a rare adnexal tumor.
  • This neoplasm is deeply infiltrative and may provide a diagnostic challenge in superficial shave biopsies of skin.
  • We present a case of SEDC in an immunocompromised patient, who, after an initial shave biopsy for diagnostic purposes, underwent a complete excision of his tumor by Mohs micrographic surgery.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunocompromised Host. Male. Middle Aged. Mohs Surgery

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  • (PMID = 20010402.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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35. Wood L, Fountaine TJ, Rosamilia L, Helm KF, Clarke LE: Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. Am J Dermatopathol; 2010 Dec;32(8):764-8
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  • [Title] Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans.
  • Spindle cell lipoma (SCL), dermatofibrosarcoma protuberans (DFSP), and solitary fibrous tumors (SFT) are cutaneous CD34+ spindle cell tumors that may exhibit histopathologic and immunophenotypic overlap.
  • Ten morphologic characteristics were analyzed in a group of 5 SCLs, 6 cutaneous SFTs, and 12 DFSPs.
  • However, adnexal entrapment, defined as diffuse proliferation of tumor cells around pilosebaceous and eccrine structures with minimal disruption or expansion of the dermis, was a feature seen in 10 of the 12 DFSPs and in none of the SFTs or SCLs.
  • The number of samples included in the study is relatively small, in part due to the rarity of cutaneous solitary fibrous tumors.
  • [MeSH-major] Antigens, CD34 / analysis. Lipoma / pathology. Skin / pathology. Skin Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Dermatofibrosarcoma / immunology. Dermatofibrosarcoma / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Pennsylvania. Predictive Value of Tests

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  • (PMID = 20559119.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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36. Crippa S, Di Bella C, Faravelli A: Skin adnexal neoplasm closely resembling adenomatoid tumor: a unique occurrence. Int J Surg Pathol; 2006 Apr;14(2):177-8
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  • [Title] Skin adnexal neoplasm closely resembling adenomatoid tumor: a unique occurrence.
  • We describe a primary skin neoplasm located in the left chest wall that closely resembled adenomatoid tumor of male and female genital tract.
  • The tumor involved the dermis and subcutaneous tissue and measured 0.7 cm in greatest diameter.
  • We are unaware of a previous description of this morphologic pattern in a primary skin tumor, which we have interpreted as of skin adnexal and specifically of eccrine sweat gland origin.
  • [MeSH-major] Adnexal Diseases / pathology. Eccrine Glands / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology. Thoracic Wall / pathology
  • [MeSH-minor] Adenomatoid Tumor / pathology. Aged. Breast Neoplasms / surgery. Carcinoma, Ductal / surgery. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 16703184.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Lee PL, Lourduraj LT, Palko MJ 3rd, Jukic DM, English JC 3rd: Hereditary basaloid follicular hamartoma syndrome. Cutis; 2006 Jul;78(1):42-6
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  • Basaloid follicular hamartoma syndrome (BFHS) is a rare adnexal tumor genodermatosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Hamartoma / diagnosis. Hand Dermatoses / diagnosis. Skin Diseases / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Syndrome


38. Choi YD, Cho NH, Park YS, Cho SH, Lee G, Park K: Lymphovascular and marginal invasion as useful prognostic indicators and the role of c-erbB-2 in patients with male extramammary Paget's disease: a study of 31 patients. J Urol; 2005 Aug;174(2):561-5
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  • PURPOSE: Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm arising in skin that bears apocrine glands.
  • We analyzed clinical, pathological and immunohistochemical staining patterns in 31 cases of EMPD to assess possible predictors of outcome, including patient age, sex, involved organs, surgical margin status, invasion depth, lymphovascular invasion, adnexal invasion, and immunoreactivity for cytokeratin 7 and 20, carcinoembryonic androgen, androgen receptor, p53, c-erbB-2 (Dako, Carpinteria, California) and Ki67.
  • Dermal invasion depth, tumor margin status, adnexal invasion and lymphovascular invasion were determined from the hematoxylin and eosin stained slides of each case.
  • [MeSH-minor] Aged. Aged, 80 and over. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Prognosis. Scrotum

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  • [ErratumIn] J Urol. 2005 Oct;174(4 Pt 1):1505. Park, Kyoungmee [added]
  • (PMID = 16006892.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, ErbB-2
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39. Cassarino DS, Derienzo DP, Barr RJ: Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two. J Cutan Pathol; 2006 Apr;33(4):261-79
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  • [Title] Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two.
  • Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential.
  • No definitive, comprehensive clinicopathological system dividing cutaneous SCCs into categories based upon their aggressiveness has yet been promulgated.
  • Intermediate-risk SCCs include adenoid (acantholytic) SCC, intraepidermal epithelioma with invasion, and lymphoepithelioma-like carcinoma of the skin.
  • High-risk subtypes include de novo SCC, SCC arising in association with predisposing factors (radiation, burn scars, and immunosuppression), invasive Bowen's disease, adenosquamous carcinoma, and malignant proliferating pilar tumors.
  • The indeterminate category includes signet ring cell SCC, follicular SCC, papillary SCC, SCC arising in adnexal cysts, squamoid eccrine ductal carcinoma, and clear-cell SCC.
  • Subclassification of SCC into these risk-based categories, along with enumeration of other factors including tumor size, differentiation, depth of invasion, and perineural invasion will provide prognostically relevant information and facilitate the most optimal treatment for patients.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Dermatology / methods. Diagnosis, Differential. Humans. Neoplastic Processes. Pathology, Surgical / methods. Risk Factors


40. Cassarino DS, Derienzo DP, Barr RJ: Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. J Cutan Pathol; 2006 Mar;33(3):191-206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
  • Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential.
  • No definitive, comprehensive clinicopathological system dividing cutaneous SCCs into categories based upon their aggressiveness has yet been promulgated.
  • Intermediate-risk SCCs include adenoid (acantholytic) SCC, intraepidermal epithelioma with invasion, and lymphoepithelioma-like carcinoma of the skin.
  • High-risk subtypes include de novo SCC, SCC arising in association with predisposing factors (radiation, burn scars, and immunosuppression), invasive Bowen's disease, adenosquamous carcinoma, and malignant proliferating pilar tumors.
  • The indeterminate category includes signet ring cell SCC, follicular SCC, papillary SCC, SCC arising in adnexal cysts, squamoid eccrine ductal carcinoma, and clear-cell SCC.
  • Subclassification of SCC into these risk-based categories, along with enumeration of other factors including tumor size, differentiation, depth of invasion, and perineural invasion will provide prognostically relevant information and facilitate the most optimal treatment for patients.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Dermatology / methods. Diagnosis, Differential. Humans. Neoplastic Processes. Pathology, Surgical / methods. Risk Factors


41. Qureshi YA, Karp CL, Dubovy SR: Intralesional interferon alpha-2b therapy for adnexal Kaposi sarcoma. Cornea; 2009 Sep;28(8):941-3
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  • [Title] Intralesional interferon alpha-2b therapy for adnexal Kaposi sarcoma.
  • PURPOSE: To describe a case of adnexal Kaposi's sarcoma successfully treated with intralesional interferon alpha 2b injections.
  • Clinical, histological, and immunohistochemical examination yielded the diagnosis of Kaposi's sarcoma.
  • This resulted in a dramatic reduction in tumor burden and lid edema, an improvement in lid position, and corneal healing.
  • CONCLUSION: Ocular adnexal and conjunctival Kaposi's sarcoma was successfully treated with 3 adjuvant intralesional interferon alpha-2b injections leading to a dramatic decrease in tumor mass.
  • [MeSH-major] Antiviral Agents / administration & dosage. Conjunctival Neoplasms / drug therapy. Eyelid Neoplasms / drug therapy. Interferon-alpha / administration & dosage. Neoplasms, Adnexal and Skin Appendage / drug therapy. Sarcoma, Kaposi / drug therapy

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  • (PMID = 19654515.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 99210-65-8 / interferon alfa-2b
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42. Karaman E, Duman C, Yagiz C: Giant trichilemmal cyst at the neck region. J Craniofac Surg; 2009 May;20(3):961-2
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  • Trichilemmal cyst (TC) is an adnexal skin tumor that usually occurs on the scalp.
  • There is a female dominance in this tumor.
  • Proliferating pilar tumors or cysts arise from this lesion, and the clinical differential diagnosis from TCs must be taken because of aggressive behavior of proliferating pilar tumor.
  • [MeSH-major] Epidermal Cyst / diagnosis. Neck / pathology. Skin Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Jugular Veins / pathology. Laryngeal Diseases / pathology. Male. Middle Aged. Submandibular Gland Diseases / pathology. Thyroid Cartilage / pathology. Tomography, X-Ray Computed. Tongue Diseases / pathology

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  • (PMID = 19461343.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Zaraa I, Zeglaoui F, Fazaa B, Ezzine N, Elfekih N, Zermani R, Ben Jilani S, Kamoun MR: [Brooke-Spiegler syndrome]. Tunis Med; 2006 Sep;84(9):578-80
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  • [Transliterated title] Syndrome de brooke-Spiegler.
  • Brooke Spiegler syndrome is a rare genodermatosis characterized by an association of multiple trichoepitheliomas and cylindromas, sometimes accompanied by other adnexal tumors (spiradenoma, mila), we report two family cases of Brooke Spiegler syndrome.
  • No neoplastic tumor was identified.
  • A co-existence of adnexal tumors was found in the other members of the family.
  • Brooke Spiegler syndrome is an autosomial dominant disease with variable penetrance, it's characterized by a family history of trichoepitheliomas, with other adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics

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  • (PMID = 17263207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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44. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Sebaceous differentiation in the form of mature sebocytes varied from almost none to approximately 10%.
  • Although the neoplasm appeared benign architecturally, the presence of cytologic atypia qualified 2 tumors as low-grade carcinomas.
  • No neuroendocrine differentiation was demonstrated immunohistochemically, histochemically, and ultrastructurally.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Murphy M, Brierley T, Pennoyer J, Rozenski D, Grant-Kels JM: Lymphotropic adamantinoid trichoblastoma. Pediatr Dermatol; 2007 Mar-Apr;24(2):157-61
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  • This is a rarely reported skin adnexal tumor in adolescent patients.
  • The clinical, histologic, and immunohistochemical features of this tumor are described.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 17461815.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Valenzuela AA, Whitehead KJ, Sullivan TJ: Ocular adnexal pseudo-cyst formation as a characteristic feature of perineural spread in squamous cell carcinoma. Ophthal Plast Reconstr Surg; 2006 May-Jun;22(3):201-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ocular adnexal pseudo-cyst formation as a characteristic feature of perineural spread in squamous cell carcinoma.
  • All cases had associated cutaneous squamous cell carcinoma involving the face or scalp, and, in 4 cases, the primary tumor could be identified in the vicinity of the affected orbit.
  • The cystic tumor deposits were assessed histologically with both hematoxylin and eosin and immunoperoxidase stains (S100 protein for neural structures identification and MNF116 as a keratin marker).
  • This demonstrated malignant squamous epithelium both within and around the wall of the tumor deposit and, in continuity, within the nerve running through the lesion.
  • Some nerves showed substantial areas of fibrosis, representing obliteration of the nerve structure caused by involvement by tumor.
  • CONCLUSIONS: The presence of a cystic lesion in association with sensory or motor deficit in the periorbital region should suggest a diagnosis of perineural spread from a cutaneous squamous cell carcinoma.
  • Because these patients may present to the ophthalmologist first, an awareness of this entity is of critical importance to avoid the delayed diagnosis seen in half of our cases.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Cranial Nerve Neoplasms / secondary. Cysts / diagnosis. Orbital Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 16714930.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Bulliard C, Murali R, Maloof A, Adams S: Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. J Cutan Pathol; 2006 Dec;33(12):812-6
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  • Mucinous carcinoma of skin (MCS) is an uncommon adnexal tumor of disputed differentiation.
  • In 1995, Rahilly et al. reported a case of MCS with neuroendocrine differentiation (E-MCS).
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Neoplasm Metastasis / pathology

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  • (PMID = 17177942.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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48. Carlson RM, Haddad L, Pui JC: Brooke-Spiegler syndrome with associated pegged teeth. Cutis; 2008 Nov;82(5):345-9
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  • This combination represents a rare genetic syndrome with tumors expressing adnexal differentiation.
  • Malignant transformation is rare but reported, and surgical excision is warranted to prevent turban tumor formation of the scalp.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / physiopathology. Skin Neoplasms / physiopathology. Tooth Abnormalities / etiology
  • [MeSH-minor] Adult. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / physiopathology. Female. Genetic Testing. Humans. Mutation. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / genetics. Neoplastic Syndromes, Hereditary / physiopathology. Syndrome. Tumor Suppressor Proteins / genetics

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  • (PMID = 19090338.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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49. Tellechea O, Reis JP: Trichogerminoma. Am J Dermatopathol; 2009 Jul;31(5):480-3
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  • A case of distinctive benign follicular neoplasm previously reported under the designation of trichogerminoma is described.
  • Small follicle bulb-like basophilic structures, foci of sebaceous differentiation, and areas of infundibulocystic, isthmic, and outer sheath keratinization were also seen.
  • This neoplasm and the other tumors with hair germ differentiation such as trichoblastoma and panfolliculoma seem to represent the same spectrum of hair follicle neoplasms only distinguishable by their degree of differentiation.
  • [MeSH-major] Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Scalp / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 19542926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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50. Kalof AN, Cooper K: D2-40 immunohistochemistry--so far! Adv Anat Pathol; 2009 Jan;16(1):62-4
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  • More recently, D2-40 immunoexpression has been reported in primary adrenal cortical tumors, schwannomas, and adnexal tumors of the skin.
  • [MeSH-major] Antibodies, Monoclonal. Biomarkers, Tumor / analysis

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  • (PMID = 19098468.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
  • [Number-of-references] 14
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51. Cartaginese F, Sidoni A: Melanocytic matricoma. Report of a further case with clinicopathological and immunohistochemical findings, differential diagnosis and review of the literature. Histol Histopathol; 2010 06;25(6):713-7
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  • [Title] Melanocytic matricoma. Report of a further case with clinicopathological and immunohistochemical findings, differential diagnosis and review of the literature.
  • It usually presents as a pigmented, dark-papular, crusted lesion on sun-damaged skin of adult patients.
  • It differs from matricomas and pilomatricomas by its lack of calcification, cyst formation, granulomas, and connections to the epidermis and other adnexal structures.
  • The clinical differential diagnosis includes hemangioma, pigmented basal cell carcinoma, and melanoma.
  • We report an additional case of melanocytic matricoma with discussion of clinicopathologic features and differential diagnosis.
  • [MeSH-major] Hair Diseases / pathology. Melanocytes / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Hemangioma / diagnosis. Humans. Immunohistochemistry. Male. Melanoma / diagnosis. Treatment Outcome

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  • (PMID = 20376777.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Ishida M, Katsura K, Nagata A, Kijima K, Kushima R, Okabe H: [A case of primary mucinous carcinoma with endocrine differentiation of the skin]. Rinsho Byori; 2008 Jun;56(6):455-8
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  • [Title] [A case of primary mucinous carcinoma with endocrine differentiation of the skin].
  • Primary mucinous carcinoma of the skin (MCS) is a rare skin appendage tumor and only a few cases of MCS with endocrine differentiation have been reported.
  • Here we report an additional case of primary pure MCS with endocrine differentiation arising in the face.
  • Histopathologically, the tumor was located in the dermis and subcutis, and nests of slight atypical epithelial cells were floating in the mucinous pools.
  • This tumor did not accompany carcinoma in situ or invasive non-mucinous carcinoma and was difficult to differentiate from metastatic mucinous carcinoma of the skin.
  • There was no tumor in the other organs and synaptophysin and chromogranin A were sporadically shown immunohistochemically in the tumor cells; a diagnosis of primary pure MCS with endocrine differentiation was made.
  • Although endocrine differentiation is not uncommon in pure mucinous carcinoma of the breast, there have been only a few reports published on endocrine differentiation in MCS.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Differentiation. Humans. Male. Middle Aged

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  • (PMID = 18646630.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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53. O'Blenes CA, Lee JP, Walsh NM, Morris SF: An unusual case of turban tumor syndrome treated with total scalp excision and advancement flap and skin graft reconstruction. Ann Plast Surg; 2010 Jul;65(1):107-9
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  • [Title] An unusual case of turban tumor syndrome treated with total scalp excision and advancement flap and skin graft reconstruction.
  • We report an unusual case of aggressive turban tumor syndrome in a 38-year-old woman with nodules covering her scalp and involving her face, neck, chest, and back.
  • To address concerns regarding hygiene of the scalp and cosmetic disfigurement, she underwent total scalp excision with advancement flap and skin graft reconstruction.
  • Histologic examination of the scalp tumors revealed a predominance of spiradenomas, along with cylindromas and trichoepitheliomas, and tumors containing elements of all 3 of these adnexal neoplasms.
  • We review the literature regarding turban tumor syndrome including the genetic basis for this condition, clinical features, pathology, and treatment.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Facial Neoplasms / surgery. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplasms, Second Primary / surgery. Scalp / surgery. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 20548229.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Leibovitch I, Huilgol SC, Richards S, Paver R, Selva D: Periocular microcystic adnexal carcinoma: management and outcome with Mohs' micrographic surgery. Ophthalmologica; 2006;220(2):109-13
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  • [Title] Periocular microcystic adnexal carcinoma: management and outcome with Mohs' micrographic surgery.
  • PURPOSE: To report a series of patients with periocular microcystic adnexal carcinoma (MAC) treated with Mohs' micrographic surgery (MMS).
  • METHODS: This series included all patients treated with MMS for periocular MAC, who were monitored by the Skin and Cancer Foundation Australia between 1993 and 2002.
  • The tumor was initially misdiagnosed as basal cell carcinoma in 3 patients and squamous cell carcinoma in 1 patient.
  • The average number of excision levels required for complete removal of the tumor during MMS was 2.2 (range 1-6).
  • Perineural invasion was recorded in one patient.Five-year follow-up data was available for 3 patients, and there was no tumor recurrence in any of these cases.
  • CONCLUSION: The low 5-year recurrence rate of periocular MAC with MMS emphasizes the importance of margin-controlled excision of this tumor.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Eyelid Neoplasms / surgery. Mohs Surgery / methods
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 16491033.001).
  • [ISSN] 0030-3755
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Switzerland
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55. Kumar B: Chondroid syringoma diagnosed by fine needle aspiration cytology. Diagn Cytopathol; 2010 Jan;38(1):38-40
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  • Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region.
  • It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components.
  • There are only few case reports describing the fine needle aspiration cytologic features of chondroid syringoma for diagnosis.
  • Overlying skin was normal, and the swelling was fixed to the skin but freely mobile over underlying structure.
  • A clinical diagnosis of dermoid cyst was entertained, and the case was subjected to FNAC.
  • On the basis of these cytologic features, a diagnosis of chondroid syringoma was made.
  • We concluded that Chondroid syringoma may be considered as a rare differential diagnosis in the swelling of head and neck region and the diagnosis can be easily confirmed or ruled out by means of fine needle aspiration cytology.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19693940.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Fujiwara M, Taube J, Sharma M, McCalmont TH, Kim J: PAX8 discriminates ovarian metastases from adnexal tumors and other cutaneous metastases. J Cutan Pathol; 2010 Sep;37(9):938-43
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  • [Title] PAX8 discriminates ovarian metastases from adnexal tumors and other cutaneous metastases.
  • BACKGROUND: The distinction of metastatic ovarian carcinoma from other metastatic carcinomas and primary adnexal lesions in the skin is often difficult.
  • Identification of ovarian cutaneous metastases may be of benefit in patients with familial breast-ovarian carcinoma syndrome.
  • METHODS: PAX8 immunohistochemical analysis was performed on 24 cases of metastatic adenocarcinomas to the skin and compared with 7 cases of primary adnexal lesions and also compared with p63 immunohistochemical staining results.
  • Patients with metastatic adenocarcinomas had clinically documented primary malignancies, and patients with primary adnexal carcinomas had no known history of another adenocarcinoma.
  • RESULTS: Cutaneous ovarian and renal cell carcinoma metastases (2/2 and 8/8, respectively) showed positive nuclear expression of PAX8.
  • PAX8 immunohistochemical staining in primary adnexal and other cutaneous metastases was completely negative (0/7 and 0/16, respectively).
  • The p63 expression profile supported the distinction between adnexal and metastatic adenocarcinomas.
  • CONCLUSIONS: Although cutaneous ovarian metastasis is a rare phenomenon, the prognosis is extremely poor.
  • PAX8 expression is a useful marker that effectively discriminated metastatic ovarian carcinomas from metastatic breast carcinomas and primary adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis. Ovarian Neoplasms / diagnosis. Paired Box Transcription Factors / metabolism. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20492080.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors
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57. Tan D, Kraybill W, Cheney RT, Khoury T: Retiform hemangioendothelioma: a case report and review of the literature. J Cutan Pathol; 2005 Oct;32(9):634-7
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  • BACKGROUND: Retiform hemangioendothelioma (RH) is a rare, recently described vascular neoplasm of low malignant potential.
  • Histologically, the tumor grew as numerous elongated vessels resembling the shape of rete testis with involvement of the skin adnexal structures and subcutaneous adipose tissue.
  • [MeSH-major] Hemangioendothelioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16176302.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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58. Ramos-Vara JA, Miller MA: Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides). Vet Pathol; 2007 Jan;44(1):74-9
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  • During immunohistochemical evaluation of a cutaneous epitheliotropic T-cell lymphoma (mycosis fungoides [MF]) in a dog, strong reactivity for PGP 9.5 was observed.
  • Immunoreactivity did not correlate with location (epidermal, dermal, and adnexal) of tumor cells.
  • Although PGP 9.5 immunoreactivity in MF did not predict tumor behavior in these dogs, it has had prognostic value in certain human carcinomas.
  • This unexpected staining of lymphocytes in mycosis fungoides with an antibody to PGP 9.5 demonstrates its presence in nonneuroendocrine tumors and precludes its use as the sole diagnostic marker in discrete cell tumors in the skin.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Dog Diseases / enzymology. Mycosis Fungoides / enzymology. Mycosis Fungoides / veterinary. Skin Neoplasms / enzymology. Skin Neoplasms / veterinary. Ubiquitin Thiolesterase / metabolism

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  • (PMID = 17197626.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.1.2.15 / Ubiquitin Thiolesterase
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59. Cangelosi JJ, Nash JW, Prieto VG, Ivan D: Cutaneous adnexal tumor with an unusual presentation--discussion of a potential diagnostic pitfall. Am J Dermatopathol; 2009 May;31(3):278-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous adnexal tumor with an unusual presentation--discussion of a potential diagnostic pitfall.
  • The clinical presentation of skin adnexal tumors is nonspecific, and histologically; the differential diagnosis between primary cutaneous adnexal malignant carcinomas and metastatic tumors with a visceral origin can be challenging.
  • The biopsy showed an intradermal proliferation of malignant epithelioid cells with ductal differentiation, histologically compatible with metastatic breast carcinoma.
  • However, the tumor cells labeled strongly and diffusely not only for pancytokeratin and cytokeratin (CK7) but also with p63 and CK5/6; carcinoembryonic antigen highlighted the ductal structures.
  • Based on the p63 and CK5/6 positivity, the differential diagnosis also included the possibility of a primary adnexal neoplasm and a complete excision was advised.
  • The reexcision specimen revealed residual infiltrating dermal tumor and an overlying intraepithelial component with marked cytologic atypia and focal duct formation, diagnostic of a primary cutaneous adnexal tumor with ductal differentiation (porocarcinoma).
  • Immunohistochemical studies (like p63 and CK5/6) can help to differentiate a primary cutaneous neoplasm from a metastatic lesion.
  • [MeSH-major] Biomarkers, Tumor / analysis. Diagnostic Errors / prevention & control. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Second Primary. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Breast Neoplasms / secondary. Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Ductal, Breast / surgery. Cell Differentiation. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • [CommentIn] Am J Dermatopathol. 2010 Dec;32(8):853-4 [20431390.001]
  • (PMID = 19384070.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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60. Sellheyer K, Krahl D: Basal cell (trichoblastic) carcinoma common expression pattern for epithelial cell adhesion molecule links basal cell carcinoma to early follicular embryogenesis, secondary hair germ, and outer root sheath of the vellus hair follicle: A clue to the adnexal nature of basal cell carcinoma? J Am Acad Dermatol; 2008 Jan;58(1):158-67
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  • [Title] Basal cell (trichoblastic) carcinoma common expression pattern for epithelial cell adhesion molecule links basal cell carcinoma to early follicular embryogenesis, secondary hair germ, and outer root sheath of the vellus hair follicle: A clue to the adnexal nature of basal cell carcinoma?
  • BACKGROUND: Basal cell carcinoma (BCC) is still viewed by many dermatologists as a tumor of the interfollicular epidermis, although references were made early in the dermatopathologic literature to the resemblance of BCC to the hair follicle.
  • We suggest that this may be a clue to the adnexal nature of BCC and propose that BCC is the most primitive follicular tumor.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Carcinoma, Basal Cell / metabolism. Cell Adhesion Molecules / metabolism. Hair Follicle / embryology. Hair Follicle / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18158927.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / tumor-associated antigen GA733
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61. Güerrissi JO, Quiroga JP: Adnexal carcinomas of the head and neck. Indian J Plast Surg; 2008 Jul;41(2):229-34
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  • [Title] Adnexal carcinomas of the head and neck.
  • Adnexal carcinomas of the skin are rare and they derive from structures such as sweat glands, sebaceous glands, and hair follicles.
  • Adnexal tumors represent 1-2% of skin cancers.
  • Between 1998 and 2004, eight patients with malignant adnexal tumors of the head and neck were treated in the Plastic Surgery Service in Argerich Hospital in Buenos Aires, Argentina.
  • Tumor resection and local flaps were made in all cases.

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  • [Cites] Dermatologica. 1980;160(6):361-70 [6248388.001]
  • [Cites] Br J Plast Surg. 1990 Nov;43(6):702-5 [2175228.001]
  • [Cites] Int J Oral Maxillofac Surg. 1996 Jun;25(3):196-8 [8872222.001]
  • [Cites] Ann Plast Surg. 1996 Feb;36(2):194-6 [8919387.001]
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  • (PMID = 19753272.001).
  • [ISSN] 0970-0358
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2740523
  • [Keywords] NOTNLM ; Adnexal carcinomas / adnexal tumors / skin cancer
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62. Merritt BG, Snow SN, Longley BJ: Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery. Cutis; 2010 May;85(5):254-8
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  • [Title] Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery.
  • Several important cutaneous neoplasms present with basaloid cells in the dermis.
  • Desmoplastic trichoepithelioma (DTE), infiltrative/morpheaform basal cell carcinoma (BCC), and microcystic adnexal carcinoma (MAC) are tumors in this category that may be difficult to differentiate, especially when evaluating thin biopsy specimens.
  • An accurate diagnosis has important clinical implications.
  • While DTE is a benign neoplasm with indolent behavior, infiltrative/morpheaform BCC and MAC can be highly aggressive, leading to substantial local destruction and potential metastasis.
  • We present a patient with an unusual tumor demonstrating basaloid cells in the dermis and discuss the diagnostic approach for these lesions, emphasizing the potential role of cytokeratin 20 (CK20) in determining the need for Mohs micrographic surgery.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / pathology. Mohs Surgery. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-20. Male. Middle Aged. Staining and Labeling

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  • (PMID = 20540416.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20
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63. Torrijos-Aguilar A, Alegre-de Miquel V, Pitarch-Bort G, Mercader-García P, Fortea-Baixauli JM: [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases]. Actas Dermosifiliogr; 2009 Mar;100(2):126-32
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  • [Title] [Cutaneous granular cell tumor: a clinical and pathologic analysis of 34 cases].
  • [Transliterated title] Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos.
  • BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells.
  • OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature.
  • METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases).
  • The most frequently suspected clinical diagnosis was fibroma (17.65 %).
  • CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
  • [MeSH-major] Granular Cell Tumor / epidemiology. Mouth Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Child. Child, Preschool. Cytoplasmic Granules / ultrastructure. Diagnosis, Differential. Female. Fibroma / diagnosis. Humans. Male. Middle Aged. Retrospective Studies. Skin Neoplasms / chemistry. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology. Staining and Labeling. Young Adult

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  • (PMID = 19445877.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Leibovitch I, Huilgol SC, Selva D, Lun K, Richards S, Paver R: Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery. J Am Acad Dermatol; 2005 Feb;52(2):295-300
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  • [Title] Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is reported to have a high rate of recurrence with standard wide local excision.
  • METHODS: This prospective, multi-center case series included all patients in Australia treated with MMS for MAC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
  • In 31.8% of cases it was a recurrent tumor.
  • In 32.5% of cases the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Australia / epidemiology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Child. Databases, Factual. Diagnostic Errors. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prospective Studies. Retrospective Studies. Treatment Outcome


66. Pennington BE, Leffell DJ: Mohs micrographic surgery: established uses and emerging trends. Oncology (Williston Park); 2005 Aug;19(9):1165-71; discussion 1171-2, 1175
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  • Mohs micrographic surgery is a surgical technique that seeks to ensure the clearance of cutaneous tumors while maximizing normal tissue conservation.
  • This is accomplished through the sequential removal of thin layers of tissue in which the entire peripheral and deep margins are examined for residual tumor.
  • This approach appears to be superior to conventional surgical excision in the treatment of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), the two most common cancers of the skin.
  • Its efficacy in treating BCC and SCC has led clinicians to explore the role of Mohs micrographic surgery in the management of less common cutaneous neoplasms, such as melanoma, Merkel cell carcinoma, dermatofibrosarcoma protuberans, extramammary Paget's disease, and microcystic adnexal carcinoma.
  • [MeSH-minor] Adenoma / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Merkel Cell / surgery. Carcinoma, Squamous Cell / surgery. Dermatofibrosarcoma / surgery. Humans. Melanoma / surgery. Paget Disease, Extramammary / surgery. Skin Neoplasms / surgery

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  • (PMID = 16255133.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. McAllister JC, Recht B, Hoffman TE, Sundram UN: CD34+ pigmented fibrous proliferations: the morphologic overlap between pigmented dermatofibromas and Bednar tumors. Am J Dermatopathol; 2008 Oct;30(5):484-7
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  • Pigmented dermatofibrosarcoma protuberans (DFSP; Bednar tumor) constitutes 5%-10% of all cases of DFSP and shows morphologic features that overlap with melanocytic and fibrous proliferations.
  • Adnexal structures are effaced, but significant trapping of subcutaneous fat is not present.
  • [MeSH-minor] Adult. Dermis / metabolism. Dermis / pathology. Diagnosis, Differential. Female. Humans. Male. Skin Pigmentation

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  • (PMID = 18806495.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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68. Huang W, Zhao Y, Zhao J, Huang Y, Wang J, Zhang Q: Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature. Pathol Res Pract; 2010 Mar 15;206(3):180-4
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  • [Title] Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature.
  • Endometrioid carcinoma is a common tumor of the female genital tract, mainly affecting the uterus corpus and ovary.
  • The female adnexal tumor of probable wolffian origin (FATWO), although occasionally seen elsewhere, is most typically encountered in the broad ligament.
  • The tumor was confined to the tube and strongly resembled FATWO.
  • Immunohistochemically, the tumor cells were positive for AE1/AE3, epithelial membrane antigen (EMA), and p16, but negative for CD10, inhibin-alpha, calretinin, vimentin, myogenin, and desmin, CD99,CgA, and Syn.
  • We review the previously published cases of endometrioid carcinomas of the fallopian tube resembling FATWO, and discuss the principal differential diagnosis of the tumor in the fallopian tube.
  • [MeSH-major] Endometrial Neoplasms / pathology. Fallopian Tube Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Wolffian Ducts / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19457622.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
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69. Islam MN, Bhattacharyya I, Proper SA, Glanz SM, Vega JM, Hassanein AM: Melanocytic matricoma: a distinctive clinicopathologic entity. Dermatol Surg; 2007 Jul;33(7):857-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hair Diseases / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17598856.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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70. Paradela S, Castiñeiras I, Cuevas J, Almagro M, del Pozo J, Fonseca E: Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40. Am J Dermatopathol; 2008 Oct;30(5):504-8
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  • [Title] Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40.
  • Primary cutaneous mucinous carcinoma is a rare adnexal sweat gland neoplasm that mainly affects elderly people.
  • Differential diagnosis includes mammary and gastrointestinal metastatic mucinous carcinoma (MC) and secondary cutaneous involvement by underlying neoplasms.
  • She underwent partial excision of the tumor and local radiotherapy.
  • Imaging studies showed widespread cutaneous dissemination with enlargement of ipsilateral axillary lymph nodes but without evidence of underlying breast cancer.
  • A diagnosis of primary cutaneous mucinous carcinoma was made.
  • Our aim was to reevaluate the differential clinical, histopathological, and immunohistochemical criteria for distinguishing primary cutaneous mucinous carcinoma from skin metastases of visceral mucinous carcinoma, especially those arising in breast.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Antibodies, Monoclonal / metabolism. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Breast Neoplasms / diagnosis. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis

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  • (PMID = 18806501.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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71. Hoang MP, Dresser KA, Kapur P, High WA, Mahalingam M: Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol; 2008 Feb;21(2):178-85
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  • [Title] Microcystic adnexal carcinoma: an immunohistochemical reappraisal.
  • Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain.
  • In this study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell carcinoma, and eight squamous cell carcinoma of which five exhibited ductal differentiation.
  • We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative.
  • Forty percent of infiltrative basal cell carcinoma expressed CK7; while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories.
  • While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases.
  • Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10.
  • BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma.
  • In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation.
  • Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15+ and BerEP4+/-; thus, additional studies are needed to separate these two entities.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Skin Appendage / chemistry. Head and Neck Neoplasms / chemistry. Immunohistochemistry / methods. Skin Neoplasms / chemistry
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Humans. Keratin-15 / analysis. Male. Middle Aged


72. Sicinska J, Rakowska A, Czuwara-Ladykowska J, Mroz A, Lipinski M, Nasierowska-Guttmejer A, Sikorska J, Sklinda K, Slowinska M, Kowalska-Oledzka E, Walecka I, Walecki J, Rudnicka L: Cylindroma transforming into basal cell carcinoma in a patient with Brooke-Spiegler syndrome. J Dermatol Case Rep; 2007 Dec 29;1(1):4-9
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  • BACKGROUND: Brooke-Spiegler syndrome is a rare condition with a predisposition to develop cutaneous adnexal neoplasms, especially cylindromas, trichoepitheliomas and spiradenomas.
  • Histopathology confirmed cylindromas and basal cell carcinoma within the ulcerating tumor.
  • Magnetic resonance and computed tomography showed tumor infiltration into the skull lamina externa.
  • CONCLUSION: Patients with Brooke-Spiegler syndrome should be followed-up for malignant transformation of skin tumors to prevent deep penetration and possible metastases.

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  • (PMID = 21886698.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157764
  • [Keywords] NOTNLM ; basal cell carcinoma / computed tomography / cylindroma / magnetic resonance imaging / syringoma / trichoepithelioma / turban tumor
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73. Cauchi C, Visca P, Donati P, Lopez M: [Skin adnexal tumors]. Clin Ter; 2006 Jul-Aug;157(4):363-76
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  • [Title] [Skin adnexal tumors].
  • Adnexal skin tumors are rare neoplasms that develop from hair follicles, sebaceous glands and sweat glands.
  • The diagnosis in always histologic and often it is sufficient to report the lesion simply as benign or malignant.
  • When the tumor is large, the Mohs technique can be used.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 17051975.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 104
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74. Matsushita S, Uemura T, Imayama S, Sugihara H, Yamasaki M: Giant microcystic adnexal carcinoma of the scalp. J Dermatol; 2008 Nov;35(11):726-8
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  • [Title] Giant microcystic adnexal carcinoma of the scalp.
  • Microcystic adnexal carcinoma (MAC) is an uncommon, locally aggressive tumor.
  • Microscopically, the tumor showed both pilar and sweat gland differentiation.
  • Resection included the cranium; for reconstruction we used a titan mesh allograft and covered it with a free latissimus dorsi muscle flap and a mesh skin graft.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • [ErratumIn] J Dermatol. 2008 Dec;35(12):808
  • (PMID = 19120767.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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75. Ramos Pleguezuelos FM, Amérigo J, Vidal Puga C, Shahrour G, Rodríguez-Arias Palomo C, Márquez Lobo B: [Testicular epidermoid cyst]. Arch Esp Urol; 2008 Jun;61(5):643-6
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  • We describe a case of epidermal cyst of the testis, with the aim to contribute to the clinicopathological knowledge of this entity.
  • Ultrasound features were consistent with solid tumor.
  • RESULTS: An intraparenchymal cyst measuring 1,4 cm was observed, covered by epidermal epithelium with no other skin components.
  • Adnexal testicular pulp was normal.
  • CONCLUSIONS: When a preoperative diagnosis is made, a conservative treatment is recommendable, including frozen sections analysis of the cyst and adjacent testicular parenchyma to rule out a coexistent intratubular germ cell neoplasia.
  • [MeSH-major] Epidermal Cyst / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18709824.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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76. Nash JW, Barrett TL, Kies M, Ross MI, Sneige N, Diwan AH, Lazar AJ: Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. J Cutan Pathol; 2007 Jan;34(1):49-54
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  • Histologically, a nodular dermal proliferation composed of poorly differentiated epithelioid cells in nests and focally forming ducts with pseudopapillary architecture comprised the primary tumor.
  • Metastatic tumor involved nine of 28 nodes.
  • Interphase fluorescence in situ hybridization (FISH) demonstrated chromosomal amplification of the Her-2/neu locus within the tumor and a nodal metastasis.
  • We believe this to be the first demonstration of Her-2/neu amplification in a malignant skin adnexal tumor.
  • In analogy to breast carcinoma, these findings suggest the applicability of trastuzumab for patients with metastatic adnexal carcinomas demonstrating Her-2/neu amplification.


77. Kini JR, Kini H: Fine-needle aspiration cytology in the diagnosis of malignant proliferating trichilemmal tumor: Report of a case and review of the literature. Diagn Cytopathol; 2009 Oct;37(10):744-7
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  • [Title] Fine-needle aspiration cytology in the diagnosis of malignant proliferating trichilemmal tumor: Report of a case and review of the literature.
  • Malignant proliferating trichilemmal tumor is a rare cutaneous neoplasm derived from the outer root sheath of the hair follicle.
  • Fine-needle aspiration cytology is being increasingly used in the investigation of primary and metastatic cutaneous tumors.
  • We describe the cytological features of this uncommon adnexal tumor presenting as a scalp mass in a 58-year-old woman.
  • In view of its aggressive biological behavior, it is crucial for cytologists to be aware of this rare lesion and distinguish it from primary cutaneous squamous-cell carcinoma.
  • The differences on fine-needle aspiration cytology can be subtle and pose problems in diagnosis.
  • [MeSH-major] Hair Diseases / pathology. Hair Follicle / pathology. Scalp / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19405112.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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78. Krishnamurthy J, Nagappa DK: The cytology of molluscum contagiosum mimicking skin adnexal tumor. J Cytol; 2010 Apr;27(2):74-5
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  • [Title] The cytology of molluscum contagiosum mimicking skin adnexal tumor.
  • Molluscum contagiosum is a cutaneous viral infection presenting as multiple, umbilicated papules and vesicles.
  • The cytology of molluscum contagiosum in an 11-year-old boy, which presented atypically as a solitary nodule over the right cheek, mimicking a skin adnexal tumor is reported here.
  • Fine needle aspiration cytology plays a vital role in establishing the correct diagnosis of clinically unsuspected cases, and hence, the proper management of such lesions.
  • The cytology of molluscum contagiosum is characterized by the presence of numerous large intracytoplasmic basophilic bodies that push the host nucleus to the periphery, giving a signet ring appearance to the superficial epidermal cells.

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  • (PMID = 21157556.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3001182
  • [Keywords] NOTNLM ; Cytoplasmic inclusions / fine needle aspiration cytology / molluscum contagiosum
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79. Hall G, Duncan A, Azurdia R, Leonard N: Lymphoepithelioma-like carcinoma of the skin: a case with lymph node metastases at presentation. Am J Dermatopathol; 2006 Jun;28(3):211-5
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  • [Title] Lymphoepithelioma-like carcinoma of the skin: a case with lymph node metastases at presentation.
  • We report a case of a primary lymphoepithelioma-like carcinoma (LELC) of the skin.
  • The tumor was composed of islands of pleomorphic cells with a lymphocytic infiltrate.
  • Differential diagnoses included squamous cell carcinoma, adnexal carcinoma, Merkel cell tumors, lymphoepithelial lesions, lymphomas, and skin metastases.
  • The histopathologic and immunohistochemical features were those of a LELC of the skin.
  • Just over 30 cases of primary LELCs arising in the skin have been reported with only 1 documented fatality.
  • [MeSH-major] Carcinoma / pathology. Neovascularization, Pathologic / pathology. Rare Diseases / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Merkel Cell / pathology. Diagnosis, Differential. Humans. Lymphatic Metastasis. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / surgery. Male

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  • (PMID = 16778488.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Kazakov DV, Vanecek T, Nemcova J, Kacerovska D, Spagnolo DV, Mukensnabl P, Michal M: Spectrum of tumors with follicular differentiation in a patient with the clinical phenotype of multiple familial trichoepitheliomas: a clinicopathological and molecular biological study, including analysis of the CYLD and PTCH genes. Am J Dermatopathol; 2009 Dec;31(8):819-27
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  • [Title] Spectrum of tumors with follicular differentiation in a patient with the clinical phenotype of multiple familial trichoepitheliomas: a clinicopathological and molecular biological study, including analysis of the CYLD and PTCH genes.
  • We report a patient with multiple trichoepitheliomas whose biopsy material also demonstrated a range of other neoplasms with follicular differentiation, including small nodular trichoblastoma, small nodular basal cell carcinoma (BCC), and areas resembling infundibulocystic BCC/basaloid follicular hamartoma.
  • Peripheral blood and tumor tissues of the patient and his 2 daughters, who apparently had a milder phenotype, were studied for alterations in the CYLD and PTCH genes, but mutations or loss of heterozygosity was not found in either gene.
  • The occurrence of multiple follicular neoplasms within a single lesion adds evidence that, although in most cases BCC and trichoblastoma are distinct lesions, the 2 neoplasms do encompass a morphological spectrum of follicular differentiation, which is probably more overtly expressed in syndromic patients.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Basal Cell / pathology. Neoplasms, Multiple Primary / pathology. Receptors, Cell Surface / genetics. Skin Neoplasms / pathology. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Cell Differentiation. Child. Female. Humans. Male. Pedigree. Phenotype

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  • (PMID = 19730223.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Receptors, Cell Surface; 0 / Tumor Suppressor Proteins; 0 / patched receptors
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81. Mebazaa A, Boussofara L, Trabelsi A, Denguezli M, Sriha B, Belajouza C, Nouira R: Undifferentiated sebaceous carcinoma: an unusual childhood cancer. Pediatr Dermatol; 2007 Sep-Oct;24(5):501-4
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  • Sebaceous carcinoma is an aggressive, adnexal, rare malignant tumor that may arise in ocular or extra-ocular sites.
  • We report a 12-year-old boy with an ocular sebaceous carcinoma who was first seen with an asymptomatic firm, cutaneous nodule on the right eyebrow.
  • The tumor developed slowly within 1 year.
  • Close follow-up of this tumor is recommended because of the risk of aggressive behavior.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyebrows / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Cell Differentiation. Child. Humans. Male

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  • (PMID = 17958796.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
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  • [Title] Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case.
  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.
  • We describe a 61-year-old man with syringocystadenoma papilliferum developing within a nevus sebaceus with sebaceous differentiation in an intradermal tubular apocrine component of the syringocystadenoma papilliferum.
  • Although some adnexal neoplasms that develop in association with a nevus sebaceus may exhibit conjoint sebaceous, follicular, or apocrine differentiation, reflecting close embryological relations of the folliculosebaceous-apocrine unit, the feature we report on has not previously been described to the best of our knowledge.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


83. High WA, Alanen KW, Golitz LE: Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus? J Am Acad Dermatol; 2006 Sep;55(3):460-6
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  • DPN more often demonstrated adnexal spread (P < .001).
  • [MeSH-major] Nevus, Pigmented / classification. Nevus, Pigmented / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Nucleus / metabolism. Child. Child, Preschool. Dermis / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Neoplasm Invasiveness / pathology. Retrospective Studies. Subcutaneous Tissue / pathology. Tissue Distribution. Tumor Suppressor Protein p53 / metabolism


84. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • [Title] Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient.
  • BACKGROUND: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • Only after histopathologic examination were they classified as eccrine porocarcinoma, showing features of epithelial tumors with abortive ductal differentiation.
  • CONCLUSION: Eccrine porocarcinomas are potentially fatal adnexal malignancies, in which extensive metastatic dissemination may occur.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • Knowledge of the clinical pattern and histologic findings, therefore, is crucial for an early therapeutic intervention, which can reduce the risk of tumor recurrence and serious complications.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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85. Fischer S, Breuninger H, Metzler G, Hoffmann J: Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg; 2005 Jan;16(1):53-8
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  • [Title] Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor.
  • Microcystic adnexal carcinoma (MAC) belongs to the spectrum of locally aggressive adnexal carcinomas and most commonly occurs in the head and neck region.
  • Recently it has been proposed that MAC is an apocrine tumor.
  • In 1982, Goldstein and colleagues first reported MAC to be a distinct histologic entity characterized by a combination of keratinous cysts in the upper dermis, islands and strands of small basaloid, benign-appearing keratinocytes or squamous cells in the deeper dermis within a dense desmoplastic stroma, and areas of ductular differentiation.
  • The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time.
  • Local recurrences of the tumor occurred, despite histographic surgery because in hematoxylin and eosin stains, small islands of the deceptively benign-appearing small basaloid cells of MAC were not recognized as tumor cells.
  • The reported case demonstrates the difficulties in diagnosing MAC and indicates that MAC should always be considered in the differential diagnosis of slowly growing tumors in the head and neck region.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Basal Cell / pathology

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  • (PMID = 15699645.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Bohn AA, Wills T, Caplazi P: Basal cell tumor or cutaneous basilar epithelial neoplasm? Rethinking the cytologic diagnosis of basal cell tumors. Vet Clin Pathol; 2006 Dec;35(4):449-53
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  • [Title] Basal cell tumor or cutaneous basilar epithelial neoplasm? Rethinking the cytologic diagnosis of basal cell tumors.
  • A 1-cm-diameter, red, raised, cutaneous mass over the dorsal surface of the left third metacarpal of a 6-year-old neutered male yellow Labrador Retriever was aspirated.
  • The cytologic interpretation was malignant neoplasia with histiocytic inflammation.
  • Histologically, the tumor was diagnosed as a basal cell epithelioma.
  • Neoplasms that once were lumped into the broad histologic diagnosis of basal cell tumors have since been split into distinct entities, dependent on evidence of differentiation into epidermis, trichofollicular epithelium, or sweat or sebaceous glands.
  • Although histologic reclassification has resulted in removal of most of these entities from the original basal cell tumor category, a cytologic diagnosis of basal cell tumor continues to be used to represent the large, heterogeneous group of epidermal, trichofollicular, and adnexal skin tumors with basal cell characteristics.
  • The case in this report demonstrates the heterogeneity of neoplasms that may be diagnosed cytologically as basal cell tumors and supports the need for cytologic criteria and nomenclature that better reflect potential variation in tissue differentiation.

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  • (PMID = 17123253.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Torres A, Torres K, Paszkowski T, Staśkiewicz G, Maciejewski R, Woźniakowska E, Zaleska W: [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy]. Ginekol Pol; 2007 Oct;78(10):764-7
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  • [Title] [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy].
  • OBJECTIVES: The aim of the study was to compare serum concentrations of the TNF-alpha (TNF-alpha) in the early postoperative period in patients with benign adnexal masses operated by laparoscopy or laparotomy.
  • MATERIAL AND METHODS: The study was conducted in a group of patients aged from 20 to 52, operated due to adnexal masses.
  • [MeSH-major] Biomarkers, Tumor / blood. Laparoscopy. Laparotomy. Ovarian Diseases / blood. Ovarian Diseases / surgery. Postoperative Period. Tumor Necrosis Factor-alpha / blood
  • [MeSH-minor] Adnexal Diseases / blood. Adnexal Diseases / surgery. Adult. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Adnexal and Skin Appendage / blood. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / surgery. Ovarian Neoplasms / blood. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18200965.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Necrosis Factor-alpha
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88. Swick BL, Baum CL, Walling HW: Rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature. J Cutan Pathol; 2009 Nov;36(11):1200-5
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  • [Title] Rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature.
  • Excision showed typical histologic changes of nevus sebaceus including epidermal papillomatosis with reduced numbers of hair follicles as well as numerous sebaceous glands high in the dermis that focally emptied directly to the overlying epidermis.
  • Histologic sections of the papular growth at the superior pole of the nevus sebaceus showed a proliferation of cytologically bland basaloid epithelial tumor lobules both in the superficial dermis, with multiple connections to the epidermis, and within the deeper dermis in a nodular growth pattern demonstrating papillary mesenchymal bodies.
  • The histologic features resembled those of rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus, an association not previously described.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / complications. Neoplasms, Adnexal and Skin Appendage / pathology. Nevus, Sebaceous of Jadassohn / complications

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  • (PMID = 19469871.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 32
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89. Vidal CI, Goldberg M, Burstein DE, Emanuel HJ, Emanuel PO: p63 Immunohistochemistry is a useful adjunct in distinguishing sclerosing cutaneous tumors. Am J Dermatopathol; 2010 May;32(3):257-61
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  • [Title] p63 Immunohistochemistry is a useful adjunct in distinguishing sclerosing cutaneous tumors.
  • Cutaneous sclerosing epithelial neoplasms are often difficult to diagnose.
  • We aimed to assess the utility of p63 immunohistochemical staining in distinguishing microcystic adnexal carcinoma (MAC) from sclerosing basal cell carcinoma (SBCC) and desmoplastic trichoepithelioma (DTE).
  • Although all adnexal tumors examined demonstrated p63 expression, the pattern of staining was strikingly different in MAC when compared with other tumor types.
  • MAC exhibited a scattered pattern with p63-positive cells around the periphery of tumor nests and minimal staining within the center of the tumor islands.
  • We believe this pattern reflects the multi-differentiation pathway of MAC, with eccrine/sebaceous differentiation occurring at deeper levels of the dermis.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Carcinoma, Skin Appendage / diagnosis. Skin Neoplasms / diagnosis. Trans-Activators / analysis. Tumor Suppressor Proteins / analysis


90. Carlson JA, Cribier B, Nuovo G, Rohwedder A: Epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn. J Am Acad Dermatol; 2008 Aug;59(2):279-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The hamartoma nevus sebaceus (NS) presents at birth or early childhood as a yellowish plaque characterized histologically by variable acanthosis, papillomatosis, sebaceus hyperplasia, and proliferations of adnexal structures.
  • METHODS: DNA was retrieved from 44 formalin-fixed, paraffin-embedded samples of NS (22 with secondary tumors [eg, trichoblastoma, verruca, syringocystadenoma papilliferum] and two epidermal nevi [EN]).
  • No differences were detected comparing frequency of HPV DNA detected with respect to age or presence of a secondary tumor.
  • By in situ hybridization, 64% (18/28) were positive, showing a low-intensity, punctate nuclear signal in epidermal and adnexal keratinocytes, indicating viral integration and low viral genome copy number.
  • LIMITATIONS: Absence of adjacent, uninvolved normal-appearing skin control samples.
  • Whether HPV represents a commensal infection caused by localized cutaneous predisposition, or is an essential factor in the pathogenesis of NS is unknown.
  • The high frequency of oncogenic HPV types implicates maternal transmission of HPV and infection of an ectodermal stem cell leading to an epigenetic mosaic and altered skin development manifested along Blaschko's lines.


91. Gatti A, di Meo N, Trevisan G: Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. Acta Dermatovenerol Alp Pannonica Adriat; 2010 Dec;19(4):23-5
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  • Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Melanoma / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male


92. Krahl D, Sellheyer K: p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology. Br J Dermatol; 2010 Jul;163(1):138-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology.
  • BACKGROUND: Tumour development is frequently described in the basic pathology literature as a recapitulation of embryogenesis.
  • However, a link between the embryology of the skin and the histogenesis of adnexal tumours has been largely overlooked.
  • We therefore speculated that it is involved in the histogenesis of follicular adnexal tumours.
  • OBJECTIVES: To describe the expression pattern of p75NTR during cutaneous embryogenesis, in the adult hair follicle and in morphoeic basal cell carcinoma and desmoplastic trichoepithelioma.
  • In contrast, the lack of p75NTR expression in morphoeic basal cell carcinoma favours a concept of this tumour as a more primitive follicular lesion with the characteristics of a carcinoma and not a hamartoma.
  • We suggest including p75NTR as a tool in the differential diagnosis between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Hair Follicle / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptor, Nerve Growth Factor / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Merkel Cells / metabolism. Middle Aged. Skin / embryology. Skin / metabolism

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  • (PMID = 20184585.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptor, Nerve Growth Factor
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93. Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R: Syringocystadenoma papilliferum: report of 8 cases. Pathologica; 2006 Jun;98(3):178-80
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  • Syringocystadenoma papilliferum (SCAP) is a rare cutaneous adnexal neoplasm with variable clinical appearance and characteristic histology.
  • It arises in about one third of cases within a sebaceous hamartoma (SH) and in this case, multiple other benign adnexal neoplasms may be associated with it.
  • The age at the time of the diagnosis varied from 3 to 48 years with an average age of 28 years.

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  • (PMID = 17036946.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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94. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Familial cylindromatosis (Brooke-Spiegler syndrome) is a rare autosomal dominant inherited disease characterized by the development of adnexal tumors, mostly cylindromas, but also trichoepitheliomas and spiradenomas.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • Since the Brooke-Spiegler syndrome is characterized by a germline mutation in the CYLD oncosuppressor gene, a biphasic tumor in this setting may represent a true carcinosarcoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

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  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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95. Petersson F, Kutzner H, Spagnolo DV, Bisceglia M, Kacerovska D, Vazmitel M, Michal M, Kazakov DV: Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2009 Oct;31(7):642-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spiradenoma is a benign, morphologically well-defined cutaneous adnexal neoplasm that is closely related to cylindroma.
  • Although well-developed bilayered glands with a demonstrable peripheral myoepithelial cell layer were not recognizable in the ACC-like areas, immunohistochemistry demonstrated myoepithelial differentiation in these portions of the tumors.
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Syndrome

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  • (PMID = 19633533.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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96. Rütten A, Hantschke M, Angulo J, Requena L: Clear-cell dermal duct tumour: another distinctive, previously underrecognized cutaneous adnexal neoplasm. Histopathology; 2007 Dec;51(6):805-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear-cell dermal duct tumour: another distinctive, previously underrecognized cutaneous adnexal neoplasm.
  • AIMS: To describe 13 examples of clear cell dermal duct tumour, a neoplasm previously underrecognized in the literature.
  • METHODS AND RESULTS: Thirteen examples of a neoplasm that we have named clear-cell dermal duct tumour were studied histopathologically and immunohistochemically.
  • In contrast to some other clear cell neoplasms of the skin, which may be associated with diabetes mellitus, none of our cases of clear cell dermal duct tumour developed in a diabetic patient.
  • (iv) small areas of necrosis en masse were seen in some neoplastic aggregations; and (v) the stroma of the neoplasm was scant.
  • [MeSH-major] Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Bowen's Disease / pathology. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Nevus / pathology. Skin Diseases / pathology


97. Fernandez-Flores A: Primary cutaneous apocrine carcinoma versus metastasis, a plea to the dermatopathology community. Am J Dermatopathol; 2010 Dec;32(8):853-4
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  • [Title] Primary cutaneous apocrine carcinoma versus metastasis, a plea to the dermatopathology community.
  • [MeSH-major] Apocrine Glands / pathology. Breast Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Second Primary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Predictive Value of Tests

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  • [CommentOn] Am J Dermatopathol. 2009 May;31(3):278-81 [19384070.001]
  • (PMID = 20431390.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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98. Preuss SF, Stenzel MJ, Hansen T, Eslick GD, Gosepath J: Inverted malignant pilomatricoma of the neck. Eur Arch Otorhinolaryngol; 2005 Apr;262(4):269-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant pilomatricoma is an uncommon malignant follicular adnexal tumor with a predilection for the head and neck among older males.
  • However, the preoperative diagnostics did not provide any further information, leading to doubts concerning the initially proposed diagnosis.
  • Histology of the resected tumor revealed a malignant pilomatricoma.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • [Cites] Arch Dermatol. 1961 Apr;83:606-18 [13700704.001]
  • [Cites] Cancer. 1996 Apr 1;77(7):1311-4 [8608508.001]
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  • (PMID = 15258812.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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99. Martorell-Calatayud A, Requena-Caballero C, Botella-Estrada R, Almenar-Medina S, Sanmartín-Jiménez O, Llombart-Cussac B, Nagore-Enguídanos E, Serra-Guillén C, Echeverría-García B, Guillén-Barona C: [Microcystic adnexal carcinoma: Mohs micrographic surgery as the treatment of choice]. Actas Dermosifiliogr; 2009 Oct;100(8):693-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microcystic adnexal carcinoma: Mohs micrographic surgery as the treatment of choice].
  • [Transliterated title] Carcinoma anexial microquístico: la cirugía micrográfica de Mohs como tratamiento de elección.
  • INTRODUCTION AND OBJECTIVES: Microcystic adnexal carcinoma is a rare and aggressive tumor that manifests clinically as a subcutaneous nodule located on the head or neck.
  • The tumor can be confused clinically and histologically with other benign and malignant skin lesions, often leading to inappropriate initial treatment.
  • The chief concern with microcystic adnexal carcinoma is the elevated morbidity and the high rate of recurrence after wide local excision.
  • MATERIAL AND METHODS: We reviewed the medical histories of 6 consecutive patients with microcystic adnexal carcinoma who underwent Mohs micrographic surgery in our dermatology department between 1995 and 2007.
  • This would provide a rationale for definitive radical treatment of the primary tumor from the outset to avoid the complications associated with recurrence.
  • The site and the absence of recurrence in all our patients who underwent Mohs micrographic surgery support the use of this technique as the treatment of choice in microcystic adnexal carcinoma.
  • [MeSH-major] Carcinoma / surgery. Facial Neoplasms / surgery. Mohs Surgery. Skin Neoplasms / surgery

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  • (PMID = 19775547.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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100. Cobellis L, Pecori E, Rigatti F, Scaffa C, Rotondi M, Messalli EM: A rare case of female pelvic mass: angioleiomyoma of the broad ligament. Eur J Gynaecol Oncol; 2007;28(5):418-20
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  • Angioleiomyoma is a benign mesenchymal neoplasm composed of smooth muscle cells and thick-walled vessels.
  • It is usually found in the skin of the lower extremities.
  • Angioleiomyoma is a very rare tumor among the ever-expanding repertoire of growth variants described in benign uterine leiomyoma.
  • More rare is a solitary tumor of the broad ligament.
  • Thus angioleiomyoma of the broad ligament is an extremely rare benign tumor of the female pelvis.
  • Gynaecological and ultrasonography exams showed a large mass with increased vascularization in the right adnexal region.
  • On pathologic examination of the specimen, the tumor was diagnosed as angioleiomyoma.
  • We present a case of angioleiomyoma of the broad ligament because of its extreme rarity and the large size of the tumor.
  • [MeSH-major] Adnexal Diseases / pathology. Angiomyoma / pathology. Broad Ligament

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  • (PMID = 17966227.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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