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Items 1 to 35 of about 35
1. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10

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  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16-year period.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • RESULTS: Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period.
  • Only two cases had a clinical diagnosis of adnexal tumor.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • Malignant adnexal tumors are uncommon in our setting.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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2. Panagiotopoulos A, Chasapi V, Nikolaou V, Stavropoulos PG, Kafouros K, Petridis A, Katsambas A: Assessment of cryotherapy for the treatment of verrucous epidermal naevi. Acta Derm Venereol; 2009;89(3):292-4
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  • Epidermal naevi are hamartomas that are characterized by hyperplasia of the epidermis and adnexal structures and may be associated with serious disfiguration.
  • Nine patients with verrucous epidermal naevi and two with extensive unilateral epidermal naevus were treated with cryosurgery.
  • Two cycles of open spray technique were used, 10-15 sec each, depending on the size and extent of the naevus.
  • The low cost, the simplicity of the technique and the good cosmetic result makes cryosurgery an excellent therapeutic modality for the treatment of epidermal naevus.
  • [MeSH-major] Cryosurgery / methods. Nevus, Pigmented / surgery. Skin Neoplasms / surgery

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  • (PMID = 19479129.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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3. Levecq L, De Potter P, Guagnini AP: [Epidemiology of ocular and orbital lesions referred to an ocular oncology center]. J Fr Ophtalmol; 2005 Oct;28(8):840-4
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  • The lesions were classified into four groups: intraocular lesions (69%), superficial layer lesions (18%), adnexal tissues lesions (7%) and orbital lesions (6%).
  • The most frequent tumors were retinoblastoma in children and teenagers, conjunctival nevus young adults, choroidal melanoma in slightly older patients and posterior choroidal nevus in elderly people.

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  • (PMID = 16249763.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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4. Goddard DS, Rogers M, Frieden IJ, Krol AL, White CR Jr, Jayaraman AG, Robinson-Bostom L, Bruckner AL, Ruben BS: Widespread porokeratotic adnexal ostial nevus: clinical features and proposal of a new name unifying porokeratotic eccrine ostial and dermal duct nevus and porokeratotic eccrine and hair follicle nevus. J Am Acad Dermatol; 2009 Dec;61(6):1060.e1-14
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  • [Title] Widespread porokeratotic adnexal ostial nevus: clinical features and proposal of a new name unifying porokeratotic eccrine ostial and dermal duct nevus and porokeratotic eccrine and hair follicle nevus.
  • Porokeratotic eccrine ostial and dermal duct nevus and a similar condition, porokeratotic eccrine and hair follicle nevus, are rare disorders of keratinization with eccrine and hair follicle involvement.
  • Two patients presented with erosions in the newborn period as the initial manifestation of their disease; one had an associated structural anomaly, unilateral breast hypoplasia; and one adult had malignant transformation in the nevus with development of multifocal squamous cell carcinomas.
  • Based on the observation of overlapping histologic features, we propose the name "porokeratotic adnexal ostial nevus" to incorporate the previously described entities porokeratotic eccrine ostial and dermal duct nevus and porokeratotic eccrine and hair follicle nevus.
  • [MeSH-major] Nevus, Intradermal / pathology. Porokeratosis / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19664847.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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5. Baandrup L, Haedersdal M: [Organoid nevus (nevus sebaceus) dominated by the apocrine glands]. Ugeskr Laeger; 2005 Aug 8;167(32):2900-1
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  • [Title] [Organoid nevus (nevus sebaceus) dominated by the apocrine glands].
  • [Transliterated title] Organoidt naevus (naevus sebaceus) med apokrin dominans.
  • We report a case of congenital organoid nevus with an excessive number of apocrine glands.
  • In rare cases, various types of adnexal neoplasms may develop, but malignant tumours occur very seldom.
  • [MeSH-major] Apocrine Glands / pathology. Nevus / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16109197.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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6. Kishida ES, Muniz Silva MA, da Costa Pereira F, Sanches JA Jr, Sotto MN: Epidermal nevus syndrome associated with adnexal tumors, spitz nevus, and hypophosphatemic vitamin D-resistant rickets. Pediatr Dermatol; 2005 Jan-Feb;22(1):48-54
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  • [Title] Epidermal nevus syndrome associated with adnexal tumors, spitz nevus, and hypophosphatemic vitamin D-resistant rickets.
  • The epidermal nevus syndrome is the association of epidermal nevi with abnormalities in other organ systems, most commonly the central nervous system, the skeletal system, and the eyes.
  • We present a patient with epidermal nevus syndrome associated with hypophosphatemic vitamin D-resistant rickets and multiple adnexal and spindle cell tumors.
  • [MeSH-major] Hypophosphatemia, Familial / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Child. Female. Humans. Hypophosphatemia / metabolism. Nevus. Nevus, Pigmented. Skin. Syndrome


7. Emsen IM, Livaoglu A: An uncommon folliculosebaceous cystic hamartoma on the lower extremity. Can J Plast Surg; 2007;15(4):231-3

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  • Clinical differential diagnoses included nevus, neurofibroma and adnexal tumour.

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  • [Cites] J Dermatol. 1993 Nov;20(11):712-4 [8300942.001]
  • [Cites] Am J Dermatopathol. 1993 Jun;15(3):277-9 [8517500.001]
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  • (PMID = 19554184.001).
  • [ISSN] 1195-2199
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2696010
  • [Keywords] NOTNLM ; Exophytic papules / Folliculosebaceous cystic hamartoma / Hamartoma / Immunohistological features / Nodules / Sebaceous glands
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8. Lountzis N, Junkins-Hopkins J, Uberti-Benz M, Elenitsas R: Microcystic adnexal carcinoma arising within a nevus sebaceus. Cutis; 2007 Oct;80(4):352-6
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  • [Title] Microcystic adnexal carcinoma arising within a nevus sebaceus.
  • Nevus sebaceus (NS) is a congenital skin lesion arising on the face and scalp that has been linked to the development of various carcinomas.
  • We describe a case of microcystic adnexal carcinoma (MAC) arising in an NS on the scalp of a 62-year-old man.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Scalp. Sebaceous Gland Neoplasms / pathology


9. Terenzi V, Indrizzi E, Buonaccorsi S, Leonardi A, Pellacchia V, Fini G: Nevus sebaceus of Jadassohn. J Craniofac Surg; 2006 Nov;17(6):1234-9
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  • [Title] Nevus sebaceus of Jadassohn.
  • The nevus sebaceus of Jadassohn (SNJ) is a hamartomatous disorder of the skin and its adnexa pertaining to the group of "organoid nevi,'' most frequently involving the face and scalp.
  • During adulthood, patients with SNJ have a 10% to 20% risk of the development of cutaneous or adnexal neoplasia, so that prophylactic excision before puberty is recommended by most authors, and tissue expansion is considered to be the best method of reconstruction.

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  • (PMID = 17119437.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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10. High WA, Alanen KW, Golitz LE: Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus? J Am Acad Dermatol; 2006 Sep;55(3):460-6
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  • [Title] Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus?
  • BACKGROUND: We compare features of two similar nevi which may be confused with melanoma: deep penetrating nevus (DPN), and nevus with focal atypical epithelioid component (NFAEC).
  • RESULTS: Clinical features were similar for each type of nevus.
  • NFAEC more often demonstrated a junctional component (P < .001) and coexistent common nevus with congenital features (P = .035).
  • DPN more often demonstrated adnexal spread (P < .001).
  • [MeSH-major] Nevus, Pigmented / classification. Nevus, Pigmented / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology


11. Philipone E, Chen S: Unique case: syringocystadenoma papilliferum associated with an eccrine nevus. Am J Dermatopathol; 2009 Dec;31(8):806-7
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  • [Title] Unique case: syringocystadenoma papilliferum associated with an eccrine nevus.
  • Syringocystadenoma papilliferum is a benign adnexal lesion of the skin most commonly found in the head and neck region.
  • It is frequently seen in association with other benign adnexal lesions.
  • We report a case of syringocystadenoma papilliferum seen in conjunction with an eccrine nevus.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Sweat Gland Neoplasms / pathology


12. Hivnor CM, Yan AC, Honig PJ: Acne arising in an epidermal nevus. Pediatr Dermatol; 2007 Sep-Oct;24(5):534-5
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  • [Title] Acne arising in an epidermal nevus.
  • Epidermal nevi can demonstrate a variety of histologic patterns and contain hamartomatous hyperplasia of any epidermal or adnexal structure.
  • We present the first reported instance of acne arising strictly within a preexisting keratinocytic epidermal nevus during puberty, which is a demonstration of genetic mosaicism in pilosebaceous units.
  • [MeSH-major] Acne Vulgaris / etiology. Acne Vulgaris / pathology. Nevus / complications. Nevus / pathology


13. González-Vela MC, Val-Bernal JF, Garcia-Alberdi E, González-López MA, Fernández-Llaca JH: Trichoadenoma associated with an intradermal melanocytic nevus: a combined malformation. Am J Dermatopathol; 2007 Feb;29(1):92-5
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  • [Title] Trichoadenoma associated with an intradermal melanocytic nevus: a combined malformation.
  • Melanocytic nevi have been associated with epidermal hyperplasia, adnexal hyperplasia with follicular and sebaceous differentiation, cysts, and tumors of epidermal or adnexal origin.
  • We report a combined cutaneous hamartoma in a 29-year-old woman that comprised a trichoadenoma within an intradermal melanocytic nevus.
  • Clinical diagnosis was a malignant transformation of a melanocytic nevus.
  • Histopathologically, multiple keratinous cysts together with solid islands or masses of eosinophilic epithelial cells were closely intermingled with the nevus cells.
  • [MeSH-major] Adenoma / pathology. Hamartoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17284971.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Finn LS, Argenyi ZB: Congenital panfollicular nevus: report of a new entity. J Cutan Pathol; 2005 Jan;32(1):59-62
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  • [Title] Congenital panfollicular nevus: report of a new entity.
  • The various forms of non-melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units.
  • We report a unique congenital follicular nevus that fails to meet the criteria of any previously described follicular neoplasm, despite the plethora of alternatives.
  • This benign lesion of abortive hair follicles was unassociated with any established genodermatous syndrome or other adnexal neoplasm.
  • [MeSH-major] Hair Diseases / congenital. Hamartoma / congenital. Nevus / congenital. Skin Neoplasms / congenital


15. Nojavan H, Cribier B, Mehregan DR: [Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma]. Ann Dermatol Venereol; 2009 Oct;136(10):689-95
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  • [Title] [Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma].
  • [Transliterated title] Naevus de Spitz desmoplasique : analyse histopathologique et comparative avec le mélanome desmoplasique.
  • INTRODUCTION: Desmoplastic Spitz nevus is a rare variant of spitzoid tumours characterized by dermal proliferation of large epitheliod and/or fusiform melanocytes within a desmoplastic stroma, comprising thick, eosinophilic collagen bundles.
  • To establish useful histological criteria for differential diagnosis of desmoplastic Spitz nevus, we conducted a retrospective study comparing data concerning the clinical, demographic and histological characteristics of desmoplastic Spitz nevus and desmoplastic melanoma.
  • PATIENTS AND METHODS: We reviewed the slides for 28 cases of desmoplastic Spitz nevus and for 13 cases of desmoplastic melanoma obtained from the files of Pinkus Dermatopathology Laboratory (Monroe, MI, USA) during the period 1993-2005.
  • RESULTS: Desmoplastic Spitz nevus was more common in women (sex ratio M/F=0.4) and younger patients (mean age: 28.2 years) whereas the mean age of patients with desmoplastic melanoma was significantly higher (mean age: 75 years).
  • From a histopathological point of view, symmetry, circumscription, melanocytic maturation and involvement of adnexal structure were significantly more frequent in desmoplastic Spitz nevi.
  • CONCLUSION: The combination of architectural and cytological features was useful in differentiating desmoplastic Spitz nevus from desmoplastic melanoma.
  • [MeSH-major] Melanoma / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 19801251.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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16. Carlson JA, Cribier B, Nuovo G, Rohwedder A: Epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn. J Am Acad Dermatol; 2008 Aug;59(2):279-94
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  • [Title] Epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn.
  • BACKGROUND: The hamartoma nevus sebaceus (NS) presents at birth or early childhood as a yellowish plaque characterized histologically by variable acanthosis, papillomatosis, sebaceus hyperplasia, and proliferations of adnexal structures.
  • By in situ hybridization, 64% (18/28) were positive, showing a low-intensity, punctate nuclear signal in epidermal and adnexal keratinocytes, indicating viral integration and low viral genome copy number.
  • [MeSH-major] Epidermodysplasia Verruciformis / epidemiology. Nevus, Sebaceous of Jadassohn / epidemiology. Papillomaviridae / classification. Papillomavirus Infections / epidemiology

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  • (PMID = 18638629.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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17. Kantrow SM, Ivan D, Williams MD, Prieto VG, Lazar AJ: Metastasizing adenocarcinoma and multiple neoplastic proliferations arising in a nevus sebaceus. Am J Dermatopathol; 2007 Oct;29(5):462-6
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  • [Title] Metastasizing adenocarcinoma and multiple neoplastic proliferations arising in a nevus sebaceus.
  • Nevus sebaceus of Jadassohn is a hamartoma of multiple skin structures.
  • Many neoplasms have been reported to arise in association with nevus sebaceus, most commonly trichoblastoma/basal cell carcinoma and syringocystadenoma papilliferum.
  • We report a case of a 66-year-old woman with an adenocarcinoma as well as multiple neoplastic proliferations arising in a long standing nevus sebaceus on the scalp, with subsequent occipital neck metastatic disease.
  • This report illustrates an extraordinary case of adnexal neoplasia displaying various lines of differentiation arising in association with nevus sebaceus.
  • [MeSH-major] Adenocarcinoma / secondary. Head and Neck Neoplasms / secondary. Nevus / pathology. Skin Neoplasms / pathology


18. Swick BL, Baum CL, Walling HW: Rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature. J Cutan Pathol; 2009 Nov;36(11):1200-5
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  • [Title] Rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature.
  • A 36-year-old man developed a papular growth in a portion of a nevus sebaceus on the post-auricular scalp.
  • Excision showed typical histologic changes of nevus sebaceus including epidermal papillomatosis with reduced numbers of hair follicles as well as numerous sebaceous glands high in the dermis that focally emptied directly to the overlying epidermis.
  • Histologic sections of the papular growth at the superior pole of the nevus sebaceus showed a proliferation of cytologically bland basaloid epithelial tumor lobules both in the superficial dermis, with multiple connections to the epidermis, and within the deeper dermis in a nodular growth pattern demonstrating papillary mesenchymal bodies.
  • The histologic features resembled those of rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus, an association not previously described.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / complications. Neoplasms, Adnexal and Skin Appendage / pathology. Nevus, Sebaceous of Jadassohn / complications

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  • (PMID = 19469871.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 32
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19. Kazakov DV, Calonje E, Zelger B, Luzar B, Belousova IE, Mukensnabl P, Michal M: Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol; 2007 Jun;29(3):242-8
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  • [Title] Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases.
  • The authors report a small series of sebaceous carcinoma developing in nevus sebaceus of Jadassohn (also known as organoid nevus) and analyze similar cases reported in the literature.
  • All of our patients were females (age range 57-71 years; median 60 years) who had the organoid nevus on the scalp, face, or nuchal area, the rest of which was recognized clinically and/or histologically.
  • The sebaceous carcinoma was always accompanied by other benign or malignant adnexal lesions such as sebaceoma, syringocystadenoma papilliferum, syringocystadenocarcinoma papilliferum, trichoblastoma, tricholemmoma, desmoplastic tricholemmoma, or syringoma.
  • The analysis of the previously published material and our cases indicates that sebaceous carcinoma arising in organoid nevus has a female predilection and tends to occur in elderly patients.
  • It may involve any site where nevus sebaceus typically occurs.
  • It may arise alone, but it occurs more frequently as part of multiple benign and malignant adnexal tumors.
  • The rest of organoid nevus is usually recognized both clinically and microscopically, although large tumors may overgrow and mask the nevus.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17519621.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. García-Vargas A, Hafner C, Pérez-Rodríguez AG, Rodríguez-Rojas LX, González-Esqueda P, Stoehr R, Hernández-Torres M, Happle R: An epidermal nevus syndrome with cerebral involvement caused by a mosaic FGFR3 mutation. Am J Med Genet A; 2008 Sep 1;146A(17):2275-9
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  • [Title] An epidermal nevus syndrome with cerebral involvement caused by a mosaic FGFR3 mutation.
  • A 5-year-old Mexican girl had a bilateral, systematized epidermal nevus of a non-epidermolytic, non-organoid type covering large parts of her body with the exception of the scalp.
  • Clinically, this nevus was of a soft, velvety type showing affinity to the large body folds.
  • Histopathological examination revealed orthohyperkeratosis and papillomatosis without granular degeneration and without any abnormality of adnexal structures.
  • Molecular analysis of a biopsy specimen obtained from the epidermal nevus revealed a heterozygous R248C hotspot mutation in FGFR3, whereas in normal skin the FGFR3 wild-type allele was exclusively found.
  • This unusual mosaic phenotype may represent a distinct entity within the group of epidermal nevus syndromes.
  • [MeSH-major] Abnormalities, Multiple / genetics. Cerebrum / abnormalities. Mosaicism. Nevus, Pigmented / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Skin Neoplasms / genetics

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18642369.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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21. Manonukul J, Omeapinyan P, Vongjirad A: Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. Am J Dermatopathol; 2009 Oct;31(7):658-63
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  • [Title] Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case.
  • Nevus sebaceous of Jadassohn (SNJ) is a congenital, hamartoma of multiple skin structures and may classically evolve through several stages of maturation.
  • This report illustrates an extraordinary case of adnexal neoplasms displaying diverse lines of differentiation arising within lesions of SNJ.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology

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  • (PMID = 19652586.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Rütten A, Hantschke M, Angulo J, Requena L: Clear-cell dermal duct tumour: another distinctive, previously underrecognized cutaneous adnexal neoplasm. Histopathology; 2007 Dec;51(6):805-13
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  • [Title] Clear-cell dermal duct tumour: another distinctive, previously underrecognized cutaneous adnexal neoplasm.
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Bowen's Disease / pathology. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Nevus / pathology. Skin Diseases / pathology

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  • (PMID = 18042069.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
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  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.
  • We describe a 61-year-old man with syringocystadenoma papilliferum developing within a nevus sebaceus with sebaceous differentiation in an intradermal tubular apocrine component of the syringocystadenoma papilliferum.
  • Although some adnexal neoplasms that develop in association with a nevus sebaceus may exhibit conjoint sebaceous, follicular, or apocrine differentiation, reflecting close embryological relations of the folliculosebaceous-apocrine unit, the feature we report on has not previously been described to the best of our knowledge.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18212545.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Kang TW, Kang H, Kim HO, Song KY, Park YM: Trichoblastoma in a child. Pediatr Dermatol; 2009 Jul-Aug;26(4):476-7

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  • A trichoblastoma is a benign adnexal neoplasm composed of follicular germinative cells.
  • To our knowledge there is no prior case report of a primary trichoblastoma occurring outside the setting of a nevus sebaceous of Jadassohn in a child before adolescence.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 19689532.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Gleason BC, Hirsch MS, Nucci MR, Schmidt BA, Zembowicz A, Mihm MC Jr, McKee PH, Brenn T: Atypical genital nevi. A clinicopathologic analysis of 56 cases. Am J Surg Pathol; 2008 Jan;32(1):51-7
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  • The atypical junctional melanocytic proliferation was associated with a large common dermal nevus component that dominated the lesion in 26 cases (46%).
  • Adnexal spread (46%) and nuclear atypia of melanocytes situated in the superficial dermis (39%) were relatively common, but dermal mitoses (7%) were uncommon and maturation was present in all cases.
  • The original nevus in this patient had only mild cytologic atypia and was present at the margins of excision.
  • The recurrent/persistent nevus was reexcised, and there was no further clinical recurrence in 11.5 additional years of follow-up.
  • [MeSH-major] Genital Neoplasms, Female / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 18162770.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Abbas O, Mahalingam M: Tumor of the follicular infundibulum: an epidermal reaction pattern? Am J Dermatopathol; 2009 Oct;31(7):626-33
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  • Of interest, approximately one fourth (25%) were associated with other cutaneous lesions, which included basal cell carcinoma, actinic keratosis, desmoplastic malignant melanoma, junctional melanocytic nevus, tricholemmoma, and epidermal inclusion cyst.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 19633534.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Reutter JC, Long EM, Morrell DS, Thomas NE, Groben PA: Eruptive post-chemotherapy in situ melanomas and dysplastic nevi. Pediatr Dermatol; 2007 Mar-Apr;24(2):135-7
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  • The lesions with in situ melanomas in addition demonstrated pagetoid spread, extension down adnexal structures, and more severe cytologic atypia.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Drug Eruptions / etiology. Dysplastic Nevus Syndrome / chemically induced. Immunosuppressive Agents / adverse effects. Melanoma / chemically induced. Skin Neoplasms / chemically induced

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  • (PMID = 17461808.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents
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28. Bakshi J, Parida PK: Syringocystadenoma papilliferum: report of first case on the pinna. J Laryngol Otol; 2006 Dec;120(12):e45
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  • Syringocystadenoma papilliferum is a benign adnexal skin tumour, which, in a third of cases, arises from an organoid nevus on the head and neck.

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  • (PMID = 17105677.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Manonukul J, Kajornvuthidej S: Sebaceous neoplasms in Siriraj Hospital, Mahidol University: a 9-year-retrospective study. J Med Assoc Thai; 2010 Aug;93(8):978-91
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  • BACKGROUND: Sebaceous neoplasms are adnexal neoplasms that contain a varying number ofsebocytes, i.e. large cells with lipid-laden vacuolated cytoplasm, soap-bubble in appearance, and crenate nuclei.
  • They are uncommon compared to other adnexal neoplasms.
  • OBJECTIVES: To study the prevalence of sebaceous neoplasms, i.e., nevus sebaceus, sebaceous hyperplasia, sebaceous adenoma, sebaceoma, sebaceous epithelioma, superficial epithelioma with sebaceous differentiation, and sebaceous carcinoma diagnosed in the Department of Pathology, Siriraj Hospital, Mahidol University during the 9-year-period between 1997 and 2005.
  • To study the prevalence of tumor transformation that occurs in nevus sebaceus.
  • MATERIAL AND METHOD: A retrospective study of all sebaceous neoplasms including Nevus sebaceous, sebaceous hyperplasia, sebaceous adenoma, sebaceoma, sebaceous epithelioma, superficial epithelioma with sebaceous differentiation, sebaceous carcinoma, and all neoplasms containing the term "sebaceous" was performed.
  • RESULTS: Two hundred seven sebaceous neoplasms (2.34%) from the 8819 skin biopsies that were taken in the Department of Pathology, Siriraj Hospital during the 9-year-period, were included After exclusion of some authentically non-sebaceous neoplasms, 182 sebaceous neoplasms were found Nevus sebaceus (n=85, 46.7%) and sebaceous hyperplasia (n=64, 35.1%) were the two most common benign lesions.
  • Tumor degeneration was found in 14 nevus sebaceus in which 21 neoplasms existed, namely, trichilemmoma (wart)-like lesion (n=4), primitive follicular induction (n=7), syringocystadenoma papilliferum (n=3), trichoblastoma (n=3), and one of each of trichoepithelioma, sebaceous adenoma, tumor of follicular infundiculum, and mucoepidermoid carcinoma.
  • CONCLUSION: Twenty-six sebaceous carcinomas out of 182 sebaceous neoplasms, occurring mostly on the patients'eyelids, were found The most common sebaceous neoplasm was nevus sebaceus (n=85); the prophylactic excision of this lesion was recommended as tumor degeneration was frequent (14 out of 85 cases).

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  • (PMID = 20718175.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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30. Abdulla AN, Covert AA, Grantmyre JE: Scrotal syringocystadenoma papilliferum: case report. Can J Urol; 2009 Jun;16(3):4684-6
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  • Syringocystadenoma papilliferum (SCAP) is a benign rare adnexal skin neoplasm, which in a third of cases arises from a nevus sebaceous and is most commonly found on the head and neck and in very rare instances found on the genitalia.

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  • (PMID = 19497181.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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31. Kim JY, Kim YC, Lee ES: Solitary eccrine syringofibroadenoma with prominent plasma cell infiltration. J Dermatol; 2007 Feb;34(2):138-41

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  • Eccrine syringofibroadenoma (ESFA) is a rare, benign, adnexal neoplasm thought to be eccrine ductal differentiation displaying variable clinical findings and characteristic histological features.
  • Acrosyringial nevus, though usually regarded as an identical lesion, is sometimes regarded as a different entity showing prominent plasma cell infiltration.
  • Clinicopathological features of both cases suggest that acrosyringeal nevus and ESFA may be of the same disease entity.

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  • (PMID = 17239154.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Ohata C, Tadokoro T, Itami S: Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas. J Dermatol; 2008 Apr;35(4):215-21
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  • Other adnexal structures and constituents in the skin were positive for ERbeta, but not for ERalpha.
  • [MeSH-major] Estrogen Receptor beta / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18419678.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta
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33. Holsinger FC, Hafemeister AC, Hicks MJ, Sulek M, Huh WW, Friedman EM: Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review. Ear Nose Throat J; 2010 Nov;89(11):534-40
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  • Lesions included adnexal neoplasm, ameloblastic fibro-odontoma, basal cell carcinoma, benign fibrous histiocytoma, blue nevus, chondrosarcoma, compound nevus, epithelioma adenoides cysticum, esthesioneuroblastoma, Ewing sarcoma, fibrosarcoma, giant cell granuloma, granulocytic sarcoma, hemangioma, hemangiopericytoma, Langerhans cell histiocytosis, lymphangioma, lymphoma, melanoma, neuroblastoma, neurofibroma, ossifying osteofibroma, osteochondroma, osteosarcoma, port wine stain, rhabdomyosarcoma, Spitz nevus, and xanthogranuloma.

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  • (PMID = 21086277.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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34. González-Vela MC, Val-Bernal JF, González-López MA, Belaustegui I, Fernández-Llaca JH: Proliferating trichilemmal cyst associated with an epidermal nevus. J Dermatol; 2008 Jan;35(1):52-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proliferating trichilemmal cyst associated with an epidermal nevus.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / etiology. Nevus / complications. Skin / pathology. Skin Neoplasms / complications


35. McCalmont TH: The amazin' mets. J Cutan Pathol; 2010 Dec;37(12):1196-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Squamous Cell. Melanoma. Neoplasm Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage. Nevus, Pigmented. Skin Neoplasms

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  • (PMID = 20950362.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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